Science.gov

Sample records for jet mk ii

  1. Deposition of 13C tracer in the JET MkII-HD divertor

    NASA Astrophysics Data System (ADS)

    Jet-Efda Contributors Likonen, J.; Hakola, A.; Strachan, J.; Coad, J. P.; Widdowson, A.; Koivuranta, S.; Hole, D. E.; Mizohata, K.; Rubel, M.; Jachmich, S.; Stamp, M.

    2011-08-01

    Migration of 13C has been investigated at JET by puffing 13CH4 into the outer midplane at the end of the 2007 campaign. The 13C deposition profile was measured with secondary ion mass spectrometry (SIMS) and Rutherford backscattering (RBS) techniques. 13C was mainly found on Tile 1 and near the outer strike point (OSP) on Tile 7. The 13C transport was modelled with the EDGE2D/NIMBUS code. Previous work indicates that migration pathways are: (1) through the main chamber scrape-off layer (SOL), (2) migration through the private flux region (PFR) aided by E × B drifts and (3) neutral migration originating near the strike points. The main contribution of this paper is to further describe the neutral migration.

  2. Deposition of 13C tracer in the JET MkII-HD divertor

    NASA Astrophysics Data System (ADS)

    Likonen, J.; Airila, M.; Alves, E.; Barradas, N.; Brezinsek, S.; Coad, J. P.; Devaux, S.; Groth, M.; Grünhagen, S.; Hakola, A.; Jachmich, S.; Koivuranta, S.; Makkonen, T.; Rubel, M.; Strachan, J.; Stamp, M.; Widdowson, A.; EFDA contributors, JET-

    2011-12-01

    Migration of 13C has been investigated at JET by injecting 13C-labelled methane at the outer divertor base at the end of the 2009 campaign. The 13C deposition profiles on carbon fibre composite divertor tiles were measured by secondary ion mass spectrometry and Rutherford backscattering techniques. 13C was mainly deposited near the puffing location on the outer divertor base tiles. High amounts of 13C were also found at the outer vertical target: at the bottom of the lower and at the top of the upper plates. Thirty-three percent of puffed 13CH4 was instantly pumped out by the divertor cryopump, which is close to the pump duct entrance. Global 13C transport in the torus was modelled by the EDGE2D/EIRENE and DIVIMP codes, and local 13C migration in the vicinity of the injection location by the ERO code. The DIVIMP and EDGE2D simulations show strong prompt deposition of 13C directly adjacent to the injection point as well as in the far scrape-off layer (SOL) along both the inner and outer divertor targets. In addition, the measured 13C deposition along the outer divertor wall tiles is qualitatively reproduced. However, EDGE2D and DIVIMP do not predict any deposition along the divertor surfaces facing the private plasma on the inner floor tile and inboard of the outer strike point on tile 5. The ERO calculations also indicate that most of the deposition occurs close to the injection location on the vertical face of the LBSRP tile and the horizontal part of tile 6.

  3. CaMK-II activation is essential for zebrafish inner ear development and acts through Delta-Notch signaling.

    PubMed

    Rothschild, Sarah C; Lahvic, Jamie; Francescatto, Ludmila; McLeod, Jamie J A; Burgess, Shawn M; Tombes, Robert M

    2013-09-01

    Zebrafish inner ear development is characterized by the crystallization of otoliths onto immotile kinocilia that protrude from sensory "hair" cells. The stereotypical formation of these sensory structures is dependent on the expression of key patterning genes and on Ca2+ signals. One potential target of Ca2+ signaling in the inner ear is the type II Ca2+/calmodulin-dependent protein kinase (CaMK-II), which is preferentially activated in hair cells, with intense activation at the base of kinocilia. In zebrafish, CaMK-II is encoded by seven genes; the expression of one of these genes (camk2g1) is enriched in hair cells. The suppression of camk2g1 expression by antisense morpholino oligonucleotides or inhibition of CaMK-II activation by the pharmacological antagonist, KN-93, results in aberrant otolith formation without preventing cilia formation. In fact, CaMK-II suppression results in additional ciliated hair cells and altered levels of Delta-Notch signaling members. DeltaA and deltaD transcripts are increased and DeltaD protein accumulates in hair cells of CaMK-II morphants, indicative of defective recycling and/or exocytosis. Our findings indicate that CaMK-II plays a critical role in the developing ear, influencing cell differentiation through extranuclear effects on Delta-Notch signaling. Continued expression and activation of CaMK-II in maculae and cristae in older embryos suggests continued roles in auditory sensory maturation and transduction.

  4. Jet physics at CDF Run II

    SciTech Connect

    Safonov, A.; /UC, Davis

    2004-12-01

    The latest results on jet physics at CDF are presented and discussed. Particular attention is paid to studies of the inclusive jet cross section using 177 pb{sup -1} of Run II data. Also discussed is a study of gluon and quark jet fragmentation.

  5. The effects of ropivacaine hydrochloride on the expression of CaMK II mRNA in the dorsal root ganglion neurons.

    PubMed

    Wen, Xianjie; Lai, Xiaohong; Li, Xiaohong; Zhang, Tao; Liang, Hua

    2016-12-01

    In this study, we identified the subtype of Calcium/calmodulin-dependent protein kinase II (CaMK II) mRNA in dorsal root ganglion neurons and observed the effects of ropivacaine hydrochloride in different concentration and different exposure time on the mRNA expression. Dorsal root ganglion neurons were isolated from the SD rats and cultured in vitro. The mRNA of the CaMK II subtype in dorsal root ganglion neurons were detected by real-time PCR. As well as, the dorsal root ganglion neurons were treated with ropivacaine hydrochloride in different concentration (1mM,2mM, 3mM and 4mM) for the same exposure time of 4h, or different exposure time (0h,2h,3h,4h and 6h) at the same concentration(3mM). The changes of the mRNA expression of the CaMK II subtype were observed with real-time PCR. All subtype mRNA of the CaMK II, CaMK IIα, CaMK IIβ, CaMK II δ, CaMK IIγ, can be detected in dorsal root ganglion neurons. With the increased of the concentration and exposure time of the ropivacaine hydrochloride, all the subtype mRNA expression increased. Ropivacaine hydrochloride up-regulate the CaMK IIβ, CaMK IIδ, CaMK IIg mRNA expression with the concentration and exposure time increasing. The nerve blocking or the neurotoxicity of the ropivacaine hydrochloride maybe involved with CaMK II.

  6. Performance Oriented Packaging Testing of Tank, Cartridge, 3 IN/50, Mk 5 Mods 0, 1, 2 for Packing Group II Solid Hazardous Materials.

    DTIC Science & Technology

    1993-04-01

    NUMBERS Performance Oriented Packaging Testing of Tank, D I k T Cartridge, 3*/50, Mk 5 Mods 0 , 1, 2 for Packing Group 11t~~c Solid Hazardous Materials r...due to their similarities in design, size, and weight, this test is considered representative of qualifica- tion testing for the Mk 5 Mods 0 , 2 3"/50...TANK, CARTRIDGE, 3"/50, MK 5 MODS 0 , 1, 2 FOR PACKING GROUP II SOLID HAZARDOUS MATERIALS Author: Karcn McDonnell Mechanical Engineer Performing

  7. [Fe II] jets from intermediate-mass protostars in Carina

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan; Bally, John

    2016-12-01

    We present new HST/WFC3-IR narrow-band [Fe II] images of protostellar jets in the Carina Nebula. Combined with five previously published sources, we have a sample of 18 jets and two Herbig-Haro (HH) objects. All of the jets we targeted with Wide-Field Camera 3 (WFC3) show bright infrared [Fe II] emission, and a few Hα candidate jets are confirmed as collimated outflows based on the morphology of their [Fe II] emission. Continuum-subtracted images clearly separate jet emission from the adjacent ionization front, providing a better tracer of the collimated jet than Hα and allowing us to connect these jets with their embedded driving sources. The [Fe II] 1.64 μm/Hα flux ratio measured in the jets is ≳5 times larger than in the adjacent ionization fronts. The low-ionization jet core requires high densities to shield Fe+ against further ionization by the FUV radiation from O-type stars in the H II region. High jet densities imply high mass-loss rates, consistent with the intermediate-mass driving sources we identify for 13 jets. The remaining jets emerge from opaque globules that obscure emission from the protostar. In many respects, the HH jets in Carina look like a scaled-up version of the jets driven by low-mass protostars. Altogether, these observations suggest that [Fe II] emission is a reliable tracer of dense, irradiated jets driven by intermediate-mass protostars. We argue that highly collimated outflows are common to more massive protostars, and that they suggest the outflow physics inferred for low-mass stars formation scales up to at least ˜8 M⊙.

  8. Performance Oriented Packaging Testing of Tank, Cartridge, 3 in/50, Mk 5 Mods 0, 1, 2 for Packing Group II Solid Hazardous Materials

    DTIC Science & Technology

    1993-01-01

    Mods 0 , 1, 2 for Packing Group II Solid Hazardous Materials 6. AUTHORIS) Karen McDonnell 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8...design, size, and weight, this test is considered representative of qualifica- tion testing for the Mk 5 Mods 0 , 2 3"/50 Cartridge Tanks as per the...PERFORMANCE ORIENTED PACKAGING TESTING OF TANK, CARTRIDGE, 3"/50, MK 5 MODS 0 , 1, 2 FOR PACKING GROUP II SOLID HAZARDOUS MATERIALS Author: Karen

  9. Simvastatin pretreatment protects cerebrum from neuronal injury by decreasing the expressions of phosphor-CaMK II and AQP4 in ischemic stroke rats.

    PubMed

    Zhu, Min-xia; Lu, Chao; Xia, Chun-mei; Qiao, Zhong-wei; Zhu, Da-nian

    2014-12-01

    Excitotoxicity and cytotoxic edema are the two major factors resulting in neuronal injury during brain ischemia and reperfusion. Ca2+/calmodulin-dependent protein kinase II (CaMK II), the downstream signal molecular of N-methyl-D-aspartate receptors (NMDARs), is a mediator in the excitotoxicity. Aquaporin 4 (AQP4), expressed mainly in the brain, is an important aquaporin to control the flux of water. In a previous study, we had reported that pretreatment of simvastatin protected the cerebrum from ischemia and reperfusion injury by decreasing neurological deficit score and infarct area (Zhu et al. PLoS One 7:e51552, 2012). The present study used a middle cerebral artery occlusion (MCAO) model to further explore the pleiotropic effect of simvastatin via CaMK II and AQP4. The results showed that simvastatin reduced degenerated cells and brain edema while decreasing the protein expressions of phosphor-CaMK II and AQP4, and increasing the ratios of Bcl-2/Bax, which was independent of cholesterol-lowering effect. Immunocomplexes formed between the subunit of NMDARs-NR3A and AQP4 were detected for the first time. It was concluded that simvastatin could protect the cerebrum from neuronal excitotoxicity and cytotoxic edema by downregulating the expressions of phosphor-CaMK II and AQP4, and that the interaction between NR3A and AQP4 might provide the base for AQP4 involving in the signaling pathways mediated by NMDARs.

  10. Electrospinning and electrically forced jets. II. Applications

    NASA Astrophysics Data System (ADS)

    Hohman, Moses M.; Shin, Michael; Rutledge, Gregory; Brenner, Michael P.

    2001-08-01

    Electrospinning is a process in which solid fibers are produced from a polymeric fluid stream (solution or melt) delivered through a millimeter-scale nozzle. This article uses the stability theory described in the previous article to develop a quantitative method for predicting when electrospinning occurs. First a method for calculating the shape and charge density of a steady jet as it thins from the nozzle is presented and is shown to capture quantitative features of the experiments. Then, this information is combined with the stability analysis to predict scaling laws for the jet behavior and to produce operating diagrams for when electrospinning occurs, both as a function of experimental parameters. Predictions for how the regime of electrospinning changes as a function of the fluid conductivity and viscosity are presented.

  11. MiR-152 may silence translation of CaMK II and induce spontaneous immune tolerance in mouse liver transplantation.

    PubMed

    Wang, Yan; Tian, Yang; Ding, Yuan; Wang, Jingcheng; Yan, Sheng; Zhou, Lin; Xie, Haiyang; Chen, Hui; Li, Hui; Zhang, Jinhua; Zhao, Jiacong; Zheng, Shusen

    2014-01-01

    Spontaneous immune tolerance in mouse liver transplantation has always been a hotspot in transplantation-immune research. Recent studies revealed that regulatory T cells (Tregs), hepatic satellite cells and Kupffer cells play a potential role in spontaneous immune tolerance, however the precise mechanism of spontaneous immune tolerance is still undefined. By using Microarray Chips, we investigated different immune regulatory factors to decipher critical mechanisms of spontaneous tolerance after mouse liver transplantation. Allogeneic (C57BL/6-C3H) and syngeneic (C3H-C3H) liver transplantation were performed by 6-8 weeks old male C57BL/6 and C3H mice. Graft samples (N = 4 each group) were collected from 8 weeks post-operation mice. 11 differentially expressed miRNAs in allogeneic grafts (Allografts) vs. syngeneic grafts (Syngrafts) were identified using Agilent Mouse miRNA Chips. It was revealed that 185 genes were modified by the 11 miRNAs, furthermore, within the 185 target genes, 11 of them were tightly correlated with immune regulation after Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Genbank data cross-comparison. Verified by real-time PCR and western blot, our results indicated that mRNA expression levels of IL-6 and TAB2 were respectively down regulated following miR-142-3p and miR-155 augment. In addition, increased miR-152 just silenced mRNA of CaMK II and down-regulated translation of CaMK II in tolerated liver grafts, which may play a critical role in immune regulation and spontaneous tolerance induction of mouse liver transplantation.

  12. Observations of Chromospheric Anemone Jets with Hinode CaII Broadband Filtergraph and Hida CaII Spectroheliograph

    NASA Astrophysics Data System (ADS)

    Morita, Satoshi; Shibata, Kazunari; Ueno, Satoru; Ichimoto, Kiyoshi; Kitai, Reizaburo; Otsuji, Ken-Ichi

    2010-08-01

    We report on the first simultaneous observations of chromospheric ``anemone'' jets in solar active regions with the Hinode Solar Optical Telescope (SOT) CaII H broadband filtergraph and the CaII K spetroheliograph on the Domeless Solar Telescope (DST) at Hida Observatory. During the period of coordinated observations, nine chromospheric anemone jets were simultaneously observed with the two instruments. These observations revealed three important features: (1) the jets are generated in the lower chromosphere; i.e., these cannot be seen in CaII K3; (2) the length and lifetime of the jets are 0.4-5 Mm and 40-320 s, respectively; (3) the apparent velocity of the jets observed with the SOT is 3-24 km s-1, while the CaII K3 component at the jets shows a blueshift (in 5 events) in the range of 2-6 km s-1. The chromospheric anemone jets are associated with mixed polarity regions, which are either small emerging flux regions or moving magnetic features. It is found that the CaII K line often shows red or blue asymmetry in the K2/K1 component; the footpoint of the jets associated with emerging flux regions often shows a redshift (2-16 km s-1), while the one with moving magnetic features shows a blueshift (˜5 km s-1). A detailed analysis of the magnetic evolution of the jet-forming regions revealed that the reconnection rate (or canceling rate) of the total magnetic flux at the footpoint of the jets is on the order of 1016 Mx s-1, and the resulting magnetic energy release rate is (1.1-10) × 1024 erg s-1, with a total energy release of (1-13) × 1026 erg for the duration of the magnetic cancellation, ˜130 s. These are comparable to the estimated total energy, ˜1026 erg, in a single chromospheric anemone jet. In addition to the DST CaII K spectroheliogram and the SOT CaII H broadband filtergram, we also used for analysis an SOT magnetogram as well as a Hida Hα filtergram. We present a physical model of the jet based on the observation, and discuss the relation between

  13. Vector space methods of photometric analysis. II - Refinement of the MK grid for B stars. III - The two components of ultraviolet reddening

    NASA Technical Reports Server (NTRS)

    Massa, D.

    1980-01-01

    This paper discusses systematic errors which arise from exclusive use of the MK system to determine reddening. It is found that implementation of uvby, beta photometry to refine the qualitative MK grid substantially reduces stellar mismatch error. A working definition of 'identical' ubvy, beta types is investigated and the relationship of uvby to B-V color excesses is determined. A comparison is also made of the hydrogen based uvby, beta types with the MK system based on He and metal lines. A small core correlated effective temperature luminosity error in the MK system for the early B stars is observed along with a breakdown of the MK luminosity criteria for the late B stars. The second part investigates the wavelength dependence of interstellar extinction in the ultraviolet wavelength range observed with the TD-1 satellite. In this study the sets of identical stars employed to find reddening are determined more precisely than in previous studies and consist only of normal, nonsupergiant stars. A multivariate analysis of variance techniques in an unbiased coordinate system is used for determining the wavelength dependence of reddening.

  14. QUASI-STATIC MODEL OF MAGNETICALLY COLLIMATED JETS AND RADIO LOBES. II. JET STRUCTURE AND STABILITY

    SciTech Connect

    Colgate, Stirling A.; Li, Hui; Fowler, T. Kenneth; Hooper, E. Bickford; McClenaghan, Joseph; Lin, Zhihong

    2015-11-10

    This is the second in a series of companion papers showing that when an efficient dynamo can be maintained by accretion disks around supermassive black holes in active galactic nuclei, it can lead to the formation of a powerful, magnetically driven, and mediated helix that could explain both the observed radio jet/lobe structures and ultimately the enormous power inferred from the observed ultrahigh-energy cosmic rays. In the first paper, we showed self-consistently that minimizing viscous dissipation in the disk naturally leads to jets of maximum power with boundary conditions known to yield jets as a low-density, magnetically collimated tower, consistent with observational constraints of wire-like currents at distances far from the black hole. In this paper we show that these magnetic towers remain collimated as they grow in length at nonrelativistic velocities. Differences with relativistic jet models are explained by three-dimensional magnetic structures derived from a detailed examination of stability properties of the tower model, including a broad diffuse pinch with current profiles predicted by a detailed jet solution outside the collimated central column treated as an electric circuit. We justify our model in part by the derived jet dimensions in reasonable agreement with observations. Using these jet properties, we also discuss the implications for relativistic particle acceleration in nonrelativistically moving jets. The appendices justify the low jet densities yielding our results and speculate how to reconcile our nonrelativistic treatment with general relativistic MHD simulations.

  15. Performance in He II of a centrifugal pump with a jet pump inducer

    NASA Astrophysics Data System (ADS)

    Daney, D. E.; Ludtke, P. R.; Kashani, A.

    1989-05-01

    The tendency of turbopumps operating in He II to cavitate makes their use in zero gravity questionable because of the zero net positive suction head (NPSH) available at the pump inlet. This paper investigates a jet pump, positioned at the inlet of a centrifugal pump with a screw inducer, as a means of operating a centrifugal pump at zero or lower NPSH. Pump performance in He II was measured as a function of NPSH for six different combinations of primary and secondary nozzles. Suction heads down to -91 mm were measured for a 3-percent reduction in developed head. These are referenced to the leading edge of the screw inducer, which is 100 mm above the jet pump inlet. Because cavitation at the primary jet always precedes cavitation in the jet pump secondary nozzle, the reverse (pressure driven) flow through a porous plug as a means of obtaining a subcooled primary jet was also tested. These tests were inconclusive.

  16. VISCOUS BOUNDARY LAYERS OF RADIATION-DOMINATED, RELATIVISTIC JETS. II. THE FREE-STREAMING JET MODEL

    SciTech Connect

    Coughlin, Eric R.; Begelman, Mitchell C. E-mail: mitch@jila.colorado.edu

    2015-08-10

    We analyze the interaction of a radiation-dominated jet and its surroundings using the equations of radiation hydrodynamics in the viscous limit. In a previous paper we considered the two-stream scenario, which treats the jet and its surroundings as distinct media interacting through radiation viscous forces. Here we present an alternative boundary layer model, known as the free-streaming jet model—where a narrow stream of fluid is injected into a static medium—and present solutions where the flow is ultrarelativistic and the boundary layer is dominated by radiation. It is shown that these jets entrain material from their surroundings and that their cores have a lower density of scatterers and a harder spectrum of photons, leading to observational consequences for lines of sight that look “down the barrel of the jet.” These jetted outflow models may be applicable to the jets produced during long gamma-ray bursts and super-Eddington phases of tidal disruption events.

  17. [Fe II] Emission Tracing Massive, Irradiated Jets from Intermediate-Mass Protostars in the Carina Nebula

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan

    2013-07-01

    We present new spectroscopy and HST and ground-based AO imaging of five protostellar jets in the Carina nebula. Near-IR [Fe II] emission traces dense gas in the jet that is self-shielded from Lyman continuum photons from nearby O-type stars, but is excited by non-ionizing FUV photons that penetrate the ionization front within the jet. New near-IR [Fe II] images reveal a substantial mass of dense, neutral gas that is not seen in Halpha emission from these jets, leading to densities and mass-loss rate estimates an order of magnitude higher than those derived from the Halpha emission measure. Higher jet mass-loss rates require higher accretion rates, implying that these jets are driven by intermediate-mass (~2-8 Msun) protostars. For two of the sources, mid-IR luminosities of the driving sources are clearly consistent with intermediate-mass protostars, while the other two driving sources are more deeply embedded and require imaging at longer wavelengths with high spatial resolution to confirm their luminosity. Tangential velocities from new proper motion measurements exceed velocities typical for lower-luminosity sources (100-200 km/s). In addition, these outflows are highly collimated, with opening angles of only a few degrees, similar to low-mass protostars. We propose that these jets reflect essentially the same outflow phenomenon seen in low-mass protostars, but that the collimated atomic jet core is irradiated and rendered observable. Thus, the jets in Carina constitute a new view of collimated jets from intermediate-mass protostars that exists in a feedback dominated environment, and offer strong additional evidence that stars up to ~8 Msun form by the same accretion mechanisms as low-mass stars.

  18. Development and Testing of a Jet Assisted Polycrystalline Diamond Drilling Bit. Phase II Development Efforts

    SciTech Connect

    David S. Pixton

    1999-09-20

    Phase II efforts to develop a jet-assisted rotary-percussion drill bit are discussed. Key developments under this contract include: (1) a design for a more robust polycrystalline diamond drag cutter; (2) a new drilling mechanism which improves penetration and life of cutters; and (3) a means of creating a high-pressure mud jet inside of a percussion drill bit. Field tests of the new drill bit and the new robust cutter are forthcoming.

  19. ATLAS jet trigger update for the LHC run II

    SciTech Connect

    Delgado, A. T.

    2015-07-01

    The CERN Large Hadron Collider is the biggest and most powerful particle collider ever built. It produces up to 40 million proton-proton collisions per second at unprecedented energies to explore the fundamental laws and properties of Nature. The ATLAS experiment is one of the detectors that analyses and records these collisions. It generates dozens of GB/s of data that has to be reduced before it can be permanently stored, the event selection is made by the ATLAS trigger system, which reduces the data volume by a factor of 105. The trigger system has to be highly configurable in order to adapt to changing running conditions and maximize the physics output whilst keeping the output rate under control. A particularly interesting pattern generated during collisions consists of a collimated spray of particles, known as a hadronic jet. To retain the interesting jets and efficiently reject the overwhelming background, optimal jet energy resolution is needed. Therefore the Jet trigger software requires CPU-intensive reconstruction algorithms. In order to reduce the resources needed for the reconstruction step, a partial detector readout scheme was developed, which effectively suppresses the low activity regions of the calorimeter. In this paper we describe the overall ATLAS trigger software, and the jet trigger in particular, along with the improvements made on the system. We then focus on detailed studies of the algorithm timing and the performance impact of the full and partial calorimeter readout schemes. We conclude with an outlook of the jet trigger plans for the next LHC data-taking period. (authors)

  20. Measurement of the inclusive jet cross section using the midpoint algorithm in Run II at CDF

    SciTech Connect

    Group, Robert Craig

    2006-01-01

    A measurement is presented of the inclusive jet cross section using the Midpoint jet clustering algorithm in five different rapidity regions. This is the first analysis which measures the inclusive jet cross section using the Midpoint algorithm in the forward region of the detector. The measurement is based on more than 1 fb-1 of integrated luminosity of Run II data taken by the CDF experiment at the Fermi National Accelerator Laboratory. The results are consistent with the predictions of perturbative quantum chromodynamics.

  1. Dynamic characteristics of peripheral jet ACV. II - Pitching motion

    NASA Astrophysics Data System (ADS)

    Mori, T.; Maeda, H.

    The dynamic pitching characteristics of peripheral jet ACV (Air Cushion Vehicle) which have a stability curtain are investigated analytically and experimentally. The measured values of moment, lift and cushion pressure are compared with numerical results noting applicability to the pitching motion. The response of ACV to the sinusoidal pitching oscillation of the ground is also studied.

  2. Performance oriented packaging testing of Mk 117 Mod 0 JATO shipping container for packing Group II solid hazardous materials. Final report

    SciTech Connect

    Dwyer, J.J.

    1992-10-01

    This Performance Oriented Packaging (POP) test was conducted to ascertain whether the Mk 117 Mod 0 JATO Shipping Container meets the Packing Group 11 requirements specified by the Code of Federal Regulations, Title 49 CFR, Parts 107 through 178, dated 31 December 1991. The packaged commodity used for the test was two inert rocket motors weighing 23 kg (50 pounds) each. This represents the current maximum commodity weight. Gross weight of the loaded container was 59 kg (1 30 pounds). The test results indicate that the container has conformed to the POP requirements.

  3. Jets.

    PubMed

    Rhines, Peter B.

    1994-06-01

    This is a discussion of concentrated large-scale flows in planetary atmospheres and oceans, argued from the viewpoint of basic geophysical fluid dynamics. We give several elementary examples in which these flows form jets on rotating spheres. Jet formation occurs under a variety of circumstances: when flows driven by external stress have a rigid boundary which can balance the Coriolis force, and at which further concentration can be caused by the beta effect; when there are singular lines like the line of vanishing windstress or windstress-curl, or the Equator; when compact sources of momentum, heat or mass radiate jet-like beta plumes along latitude circles; when random external stirring of the fluid becomes organized by the beta effect into jets; when internal instability of the mass field generates zonal flow which then is concentrated into jets; when bottom topographic obstacles radiate jets, and when frontogenesis leads to shallow jet formation. Essential to the process of jet formation in stratified fluids is the baroclinic life cycle described in geostrophic turbulence studies; there, conversion from potential to kinetic energy generates eddy motions, and these convert to quasibarotropic motions which then radiate and induce jet-like large-scale circulation. Ideas of potential vorticity stirring by eddies generalize the notion of Rossby-wave radiation, showing how jets embedded in an ambient potential vorticity gradient (typically due to the spherical geometry of the rotating planet) gain eastward momentum while promoting broader, weaker westward circulation. Homogenization of potential vorticity is an important limit point, which many geophysical circulations achieve. This well-mixed state is found in subdomains of the terrestrial midlatitude oceans, the high-latitude circumpolar ocean, and episodically in the middle atmosphere. Homogenization expels potential vorticity gradients vertically to the top and bottom of the fluid, and sideways to the edges of

  4. Triggering on B-jets at CDF II

    SciTech Connect

    Amerio, Silvia; Casarsa, Massimo; Cortiana, Giorgio; Donini, Julien; Lucchesi, Donatella; Pagan Griso, Simone; /Padua U. /INFN, Padua

    2009-01-01

    In this paper we present a trigger algorithm able to select online events enriched of b-jets. This feature is of central interest in order to extend the physics reach for standard model and minimal super symmetric model Higgs decaying into a pair of b-quarks. The algorithm fully exploits the recently upgraded CDFII tracking system and Level 2 CALorimeter cluster finder. These upgrades are necessary to cope with Tevatron increasing luminosity and provide new and refined trigger primitives that are the key elements of our algorithm together with the already existing silicon vertex trigger. A b-hadron can travel some millimeters before decaying and the trigger algorithm exploits this characteristic by searching for tracks displaced with respect to the primary vertex and matched to energetic jets of particles. We discuss the study and the optimization of the algorithm, its technical implementation as well as its performance. The new trigger provides an efficient selection for Higgs decaying into a pair of b-quarks and runs up to high luminosity with an acceptable occupancy of the available bandwidth.

  5. Observations of jets from low-luminosity stars. II - SVS 12, HH 30, near HL Tauri, and HH 34

    NASA Technical Reports Server (NTRS)

    Cohen, Martin; Jones, B. F.

    1987-01-01

    Spatially resolved spectral scans were obtained for four Herbig-Haro jets emanating from low-luminosity premain-sequence stars. There appears to be a general tendency for the excitation and electron density to diminish along these jets. For three jets, the electron density dependence is close to 1/r. HH 30's scattered stellar continuum showed much weaker Fe II lines in 1985 than in 1979, indicative of variable stellar activity. The most distant knot in HH 34's jet has the lowest excitation of any known HH object, with S II-line/H-alpha = 12.

  6. A dynamical model for FR II type radio sources with terminated jet activity

    NASA Astrophysics Data System (ADS)

    Kuligowska, Elżbieta

    2017-02-01

    Context. The extension of the KDA analytical model of FR II-type source evolution originally assuming a continuum injection process in the jet-IGM interaction towards a case of the jet's termination is presented and briefly discussed. Aims: The dynamical evolution of FR II-type sources predicted with this extended model, hereafter referred to as KDA EXT, and its application to the chosen radio sources. Methods: Following the classical approach based on the source's continuous injection and self-similarity, I propose the effective formulae describing the length and luminosity evolution of the lobes during an absence of the jet flow, and present the resulting diagrams for the characteristics mentioned. Results: Using an algorithm based on the numerical integration of a modified formula for jet power, the KDA EXT model is fitted to three radio galaxies. Their predicted spectra are then compared to the observed spectra, proving that these fits are better than the best spectral fit provided by the original KDA model of the FR II-type sources dynamical evolution.

  7. Measurement of the inclusive jet cross section at D0 Run II

    SciTech Connect

    Agram, Jean-Laurent

    2004-12-17

    This work describes the measurement of inclusive jets cross section in the DØ experiment. This cross section is computed as a function of jet transverse momentum, in several rapidity intervals. This quantity is sensitive to the proton structure and is crucial for the determination of parton distribution functions (PDF), essentially for the gluon at high proton momentum fraction. The measurement presented here gives the first values obtained for Tevatron Run II for the cross section in several rapidity intervals, for an integrated luminosity of 143 pb-1. The results are in agreement, within the uncertainties, with theoretical Standard Model predictions, showing no evidence for new physics.

  8. A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia

    PubMed Central

    Mahoney, Erin; Jackson, Saheeda; Hutzelmann, Jill; Zhao, Xin; Jia, Nan; Snyder, Ellen; Snavely, Duane; Michelson, David; Roth, Thomas; Herring, W. Joseph

    2016-01-01

    Background: Filorexant (MK-6096) is an orexin receptor antagonist; here, we evaluate the efficacy of filorexant in the treatment of insomnia in adults. Methods: A double-blind, placebo-controlled, randomized, two 4-week–period, adaptive crossover polysomnography study was conducted at 51 sites worldwide. Patients (18 to <65 years) with insomnia received 1 of 4 doses of oral filorexant (2.5, 5, 10, 20mg) once daily at bedtime during one period and matching placebo in the other period in 1 of 8 possible treatment sequences. Polysomnography was performed on night 1 and end of week 4 of each period. The primary endpoint was sleep efficiency at night 1 and end of week 4. Secondary endpoints included wakefulness after persistent sleep onset and latency to onset of persistent sleep. Results: A total of 324 patients received study treatment, 315 received ≥1 dose of placebo, and 318 ≥1 dose of filorexant (2.5mg, n=79; 5mg, n=78; 10mg, n=80; 20mg, n=81). All filorexant doses (2.5/5/10/20mg) were significantly superior to placebo in improving sleep among patients with insomnia as measured by sleep efficiency and wakefulness after persistent sleep onset on night 1 and end of week 4. The 2 higher filorexant doses (10/20mg) were also significantly more effective than placebo in improving sleep onset as measured by latency to onset of persistent sleep at night 1 and end of week 4. Filorexant was generally well tolerated. Conclusions: Orexin receptor antagonism by filorexant significantly improved sleep efficiency in nonelderly patients with insomnia. Dose-related improvements in sleep onset and maintenance outcomes were also observed with filorexant. PMID:26979830

  9. AGN jet power, formation of X-ray cavities, and FR I/II dichotomy in galaxy clusters

    NASA Astrophysics Data System (ADS)

    Fujita, Yutaka; Kawakatu, Nozomu; Shlosman, Isaac

    2016-04-01

    We investigate the ability of jets in active galactic nuclei to break out of the ambient gas with sufficiently large advance velocities. Using observationally estimated jet power, we analyze 28 bright elliptical galaxies in nearby galaxy clusters. Because the gas density profiles in the innermost regions of galaxies have not been resolved so far, we consider two extreme cases for temperature and density profiles. We also follow two types of evolution for the jet cocoons: being driven by the pressure inside the cocoon [Fanaroff-Riley (FR) type I], and being driven by the jet momentum (FR type II). Our main result is that regardless of the assumed form of the density profiles, jets with observed powers of ≲1044 erg s-1 are not powerful enough to evolve as FR II sources. Instead, they evolve as FR I sources and appear to be decelerated below the buoyant velocities of the cocoons when jets were propagating through the central dense regions of the host galaxies. This explains why FR I sources are more frequent than FR II sources in clusters. Furthermore, we predict the sizes of X-ray cavities from the observed jet powers and compare them with the observed ones-they are consistent within a factor of two if the FR I type evolution is realized. Finally, we find that the jets with a power ≳1044 erg s-1 are less affected by the ambient medium, and some of them, but not all, could serve as precursors of the FR II sources.

  10. Test and Evaluation of MK 15 UBA Battery Duration and a MK 15 UBA Oxygen Addition Solenoid

    DTIC Science & Technology

    1987-10-01

    improved battery test procedures. II. EQUIPMENT DESCRIPTION A. MK 15 UBA. The MK 15 MOD 0 UBA is a closed circuit mixed gas rebreather which utilizes a...the body and adding oxygen to the inspired gas as required. Movement of recirculating gas through the circuit is normally accomplished by the natural...inhalation and exhalation action of the divers lungs. Check valves in the mouthpiece ensure a one-way flow of gas through the circuit . Carbon Dioxide

  11. On the efficiency of jet production in FR II radio galaxies and quasars

    NASA Astrophysics Data System (ADS)

    Rusinek, Katarzyna; Sikora, Marek; Kozieł-Wierzbowska, Dorota; Godfrey, Leith

    2017-04-01

    Jet powers in many radio galaxies with extended radio structures appear to exceed their associated accretion luminosities. In systems with very low accretion rates, this is likely due to the very low accretion luminosities resulting from radiatively inefficient accretion flows. In systems with high accretion rates, the accretion flows are expected to be radiatively efficient, and the production of such powerful jets may require an accretion scenario, which involves magnetically arrested discs (MADs). However, numerical simulations of the MAD scenario indicate that jet production efficiency is large only for geometrically thick accretion flows and scales roughly with (H/R)2, where H is the disc height and R is the distance from the black hole. Using samples of FR II radio galaxies and quasars accreting at moderate accretion rates, we show that their jets are much more powerful than predicted by the MAD scenario. We discuss possible origins of this discrepancy, suggesting that it can be related to approximations adopted in magnetohydrodynamic simulations to treat optically thick accretion flow within the MAD zone, or may indicate that accretion discs are geometrically thicker than the standard theory predicts.

  12. Precise measurement of the top quark mass in the lepton+jets topology at CDF II

    SciTech Connect

    Abulencia, A.; Adelman, J.; Affolder, T.; Akimoto, T.; Albrow, M.G.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; Annovi, A.; Antos, J.; /Comenius U. /Tsukuba U.

    2007-03-01

    The authors present a measurement of the mass of the top quark from proton-antiproton collisions recorded at the CDF experiment in Run II of the Fermilab Tevatron. They analyze events from the single lepton plus jets final state (t{bar t} {yields} W{sup +}bW{sup -}{bar b} {yields} lvbq{bar q}{bar b}). The top quark mass is extracted using a direct calculation of the probability density that each event corresponds to the t{bar t} final state. The probability is a function of both the mass of the top quark and the energy scale of the calorimeter jets, which is constrained in situ by the hadronic W boson mass. Using 167 events observed in 955 pb{sup -1} of integrated luminosity, they achieve the single most precise measurement of the top quark mass, 170.8 {+-} 2.2(stat.) {+-} 1.4(syst.) GeV/c{sup 2}.

  13. HH 666: different kinematics from H α and [Fe II] emission provide a missing link between jets and outflows

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan; Kiminki, Megan M.; Bally, John

    2015-06-01

    HH 666 is an externally irradiated protostellar outflow in the Carina nebula for which we present new near-IR [Fe II] spectra obtained with the Folded-Port Infrared Echellette spectrograph at Magellan Observatory. Earlier H α and near-IR [Fe II] imaging revealed that the two emission lines trace substantially different morphologies in the inner ˜40 arcsec of the outflow. H α traces a broad cocoon that surrounds the collimated [Fe II] jet that extends throughout the parent dust pillar. New spectra show that this discrepancy extends to their kinematics. Near-IR [Fe II] emission traces steady, fast velocities of ±200 km s-1 from the eastern and western limbs of the jet. We compare this to a previously published H α spectrum that reveals a Hubble-flow velocity structure near the jet-driving source. New, second-epoch Hubble Space Telescope (HST)/Advanced Camera for Surveys (ACS) H α images reveal the lateral spreading of the H α outflow lobe away from the jet axis. H α proper motions also indicate a sudden increase in the mass-loss rate ˜1000 yr ago, while steady [Fe II] emission throughout the inner jet suggest that the burst is ongoing. An accretion burst sustained for ˜1000 yr is an order of magnitude longer than expected for FU Orionis outbursts, but represents only a small fraction of the total age of the HH 666 outflow. Altogether, available data suggests that [Fe II] traces the highly collimated protostellar jet while H α traces the entrained and irradiated outflow. HH 666 appears to be a missing link between bare jets seen in H II regions and entrained molecular outflows seen from embedded protostars in more quiescent regions.

  14. HST/WFC3 imaging of protostellar jets in Carina: [Fe II] emission tracing massive jets from intermediate-mass protostars

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan

    2013-08-01

    We present narrow-band Wide Field Camera 3 (WFC3)-UVIS and WFC3-IR images of four externally irradiated protostellar jets in the Carina nebula: HH 666, HH 901, HH 902 and HH 1066. These massive jets are unusual because they are bathed in UV radiation from dozens of nearby O-type stars, but despite the strong incident ionizing radiation, portions of the jet remain neutral. Near-IR [Fe II] images reveal dense, neutral gas that was not seen in previous studies of Hα emission. We show that near-IR [Fe II] emitting gas must be self-shielded from Lyman continuum photons, regardless of its excitation mechanism (shocks, far-ultraviolet radiation or both). High densities are required for the survival of Fe+ amid the strong Lyman continuum luminosity from Tr14, raising estimates of the mass-loss rates by an order of magnitude. Higher jet mass-loss rates require higher accretion rates on to their driving protostars, implying that these jets are driven by intermediate-mass (˜2-8 M⊙) stars. Indeed, the IR driving sources of two of these outflows have luminosities that require intermediate-mass protostars (the other two are so deeply embedded that their luminosity is uncertain). All four of these HH jets are highly collimated, with opening angles of only a few degrees, similar to those observed in low-mass protostars. We propose that these jets reflect essentially the same outflow phenomenon seen in wide-angle molecular outflows associated with intermediate- and high-mass protostars, but that the collimated atomic jet core is irradiated and rendered observable in the harsh radiative environment of the Carina nebula. In more quiescent environments, this atomic core remains invisible, and outflows traced by shock-excited molecules in the outflow cavity give the impression that these outflows have a wider opening angle. Thus, the externally irradiated jets in Carina constitute a new view of collimated jets from intermediate-mass protostars and offer strong additional evidence

  15. Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.

    PubMed

    Sazonova, Olga V; Blishchenko, Elena Yu; Tolmazova, Anna G; Khachin, Dmitry P; Leontiev, Konstantin V; Karelin, Andrey A; Ivanov, Vadim T

    2007-01-01

    Neokyotorphin [TSKYR, hemoglobin alpha-chain fragment (137-141)] has previously been shown to enhance fibroblast proliferation, its effect depending on cell density and serum level. Here we show the dependence of the effect of neokyotorphin on cell type and its correlation with the effect of protein kinase A (PKA) activator 8-Br-cAMP, but not the PKC activator 4beta-phorbol 12-myristate, 13-acetate (PMA). In L929 fibroblasts, the proliferative effect of neokyotorphin was suppressed by the Ca2+ L-type channel inhibitors verapamil or nifedipine, the intracellular Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester, kinase inhibitors H-89 (PKA), KN-62 (Ca2+/calmodulin-dependent kinase II) and PD98059 (mitogen-activated protein kinase). The proliferative effect of 8-Br-cAMP was also suppressed by KN-62 and PD98059. PKC suppression (downregulation with PMA or inhibition with bisindolylmaleimide XI) did not affect neokyotorphin action. The results obtained point to a cAMP-like action for neokyotorphin.

  16. The Estimate of Kinetic Power of Jets in FR II Radio Galaxies: Existence of Invisible Components?

    NASA Astrophysics Data System (ADS)

    Ito, Hirotaka; Kino, Motoki; Kawakatu, Nozomu; Isobe, Naoki; Yamada, Shoichi

    2008-10-01

    We investigate the total kinetic power (Lj) and age (tage) of powerful jets in FR II radio galaxies by comparison of the dynamical model of expanding cocoons with observations. We select four FR II radio sources (Cygnus A, 3C 223, 3C 284, and 3C 219), for which the mass-density profiles of the intracluster medium (ICM) are known in the literature. It is found that large fractions gtrsim0.02-0.7 of the Eddington luminosity (LEdd) are carried away as kinetic power of jets. The upper limit of estimated 2Lj/LEdd is larger than unity (lesssim10) for some sources, suggesting the possibility of super-Eddington mass accretions. As a consequence of the large powers, we also find that the total energy stored in the cocoon (Ec) exceeds the energy derived from the minimum energy condition for the energy of radiating nonthermal electrons and magnetic fields (Emin): 4 < Ec/Emin < 310. This implies that most of the energy in the cocoon is carried by invisible components such as thermal leptons (electron and positron) and/or protons.

  17. On the interaction of a sound pulse with the shear layer of an axisymmetric jet. II - Heated jets

    NASA Technical Reports Server (NTRS)

    Bayliss, A.; Maestrello, L.

    1983-01-01

    The fluctuating field of a heated jet excited by a sound pulse is simulated numerically. The fluctuations in both the flow field and the far field are studied. The flow field results depend crucially on the stability properties of the heated jet. The altered stability properties due to the heating cause a reduction in the overall fluctuations and a shift of the instability waves into lower frequencies. These changes cause a similar downward shift in the far field spectrum and a reduction in the total far field noise. The results provide a partial explanation in terms of stability theory of experimentally observed properties of the noise of heated jets.

  18. Chandra Reveals Twin X-ray Jets in the Powerful FR-II Radio Galaxy 3C353

    SciTech Connect

    Kataoka, J.; Stawarz, L.; Harris, D.E.; Siemiginowska, A.; Ostrowski, M.; Swain, M.R.; Hardcastle, M.J.; Goodger, J.L.; Iwasawa, K.; Edwards, P.G.

    2008-06-13

    We report X-ray imaging of the powerful FR II radio galaxy 3C 353 using the Chandra X-ray Observatory. 3C 353's two 4-inch wide and 2-feet long jets allow us to study in detail the internal structure of the large-scale relativistic outflows at both radio and X-ray photon energies with the sub-arcsecond spatial resolution provided by the VLA and Chandra instruments. In a 90 ks Chandra observation, we have detected X-ray emission from most radio structures in 3C 353, including the nucleus, the jet and the counterjet, the terminal jet regions (hotspots), and one radio lobe. We show that the detection of the X-ray emission associated with the radio knots and counterknots, which is most likely non-thermal in origin, puts several crucial constraints on the X-ray emission mechanisms in powerful large-scale jets of quasars and FR II sources. In particular, we show that this detection is inconsistent with the inverse-Compton model proposed in the literature, and instead implies a synchrotron origin of the X-ray jet photons. We also find that the width of the X-ray counterjet is possibly narrower than that measured in radio bands, that the radio-to-X-ray flux ratio decreases systematically downstream along the jets, and that there are substantial (kpc-scale) offsets between the positions of the X-ray and radio intensity maxima within each knot, whose magnitudes increase away from the nucleus. We discuss all these findings in the wider context of the physics of extragalactic jets, proposing some particular though not definitive solutions or interpretations for each problem. In general, we find that the synchrotron X-ray emission of extragalactic large-scale jets is not only shaped by the global hydrodynamical configuration of the outflows, but is also likely to be very sensitive to the microscopic parameters of the jet plasma. A complete, self-consistent model for the X-ray emission of extragalactic jets still remains elusive.

  19. Chandra Reveals Twin X-ray Jets in the Powerful FR II Radio Galaxy 3C 353

    SciTech Connect

    Kataoka, Jun

    2008-12-24

    We report X-ray imaging of the powerful FR II radio galaxy 3C 353 using the Chandra X-ray Observatory. 3C 353's two 4''-wide and 2'-long jets allow us to study in detail the internal structure of the large-scale relativistic outflows at both radio and X-ray photon energies with the sub-arcsecond spatial resolution provided by the VLA and Chandra instruments. In a 90 ks Chandra observation, we have detected X-ray emission from most radio structures in 3C 353, including the nucleus, the jet and the counterjet, the terminal jet regions (hotspots), and one radio lobe. We show that the detection of the X-ray emission associated with the radio knots and counterknots, which is most likely non-thermal in origin, puts several crucial constraints on the X-ray emission mechanisms in powerful large-scale jets of quasars and FR II sources. In particular, we show that this detection is inconsistent with the inverse-Compton model proposed in the literature, and instead implies a synchrotron origin of the X-ray jet photons. We also find that the width of the X-ray counterjet is possibly narrower than that measured in radio bands, that the radio-to-X-ray flux ratio decreases systematically downstream along the jets, and that there are substantial (kpc-scale) offsets between the positions of the X-ray and radio intensity maxima within each knot, whose magnitudes increase away from the nucleus. We discuss all these findings in the wider context of the physics of extragalactic jets, proposing some particular though not definitive solutions or interpretations for each problem. In general, we find that the synchrotron X-ray emission of extragalactic large-scale jets is not only shaped by the global hydrodynamical configuration of the outflows, but is also likely to be very sensitive to the microscopic parameters of the jet plasma. A complete, self-consistent model for the X-ray emission of extragalactic jets still remains elusive.

  20. Chandra Reveals Twin X-Ray Jets in the Powerful FR II Radio Galaxy 3C 353

    NASA Astrophysics Data System (ADS)

    Kataoka, J.; Stawarz, Ł.; Harris, D. E.; Siemiginowska, A.; Ostrowski, M.; Swain, M. R.; Hardcastle, M. J.; Goodger, J. L.; Iwasawa, K.; Edwards, P. G.

    2008-10-01

    We report X-ray imaging of the powerful FR II radio galaxy 3C 353 using the Chandra X-Ray Observatory. Due to 3C 353's two 4' ' wide and 2' long jets we are able to study in detail the internal structure of the large-scale relativistic outflows at both radio and X-ray photon energies with the subarcsecond spatial resolution provided by the VLA and Chandra instruments. In a 90 ks Chandra observation, we have detected X-ray emission from most radio structures in 3C 353, including the nucleus, the jet and the counterjet, the terminal jet regions (hot spots), and one radio lobe. We show that the detection of the X-ray emission associated with the radio knots and counterknots, which is most likely nonthermal in origin, puts several crucial constraints on the X-ray emission mechanisms in powerful large-scale jets of quasars and FR II sources. In particular, we show that this detection is inconsistent with the inverse-Compton model proposed in the literature and instead implies a synchrotron origin of the X-ray jet photons. We also find that the width of the X-ray counterjet is possibly narrower than that measured in radio bands, that the radio to X-ray flux ratio decreases systematically downstream along the jets, and that there are substantial (kpc-scale) offsets between the positions of the X-ray and radio intensity maxima within each knot, whose magnitudes increase away from the nucleus. We discuss all these findings in the wider context of the physics of extragalactic jets, proposing some particular although not definitive solutions or interpretations for each problem. In general, we find that the synchrotron X-ray emission of extragalactic large-scale jets is not only shaped by the global hydrodynamical configuration of the outflows, but is also likely to be very sensitive to the microscopic parameters of the jet plasma. A complete, self-consistent model for the X-ray emission of extragalactic jets still remains elusive.

  1. A model for straight and helical solar jets. II. Parametric study of the plasma beta

    NASA Astrophysics Data System (ADS)

    Pariat, E.; Dalmasse, K.; DeVore, C. R.; Antiochos, S. K.; Karpen, J. T.

    2016-11-01

    Context. Jets are dynamic, impulsive, well-collimated plasma events that develop at many different scales and in different layers of the solar atmosphere. Aims: Jets are believed to be induced by magnetic reconnection, a process central to many astrophysical phenomena. Within the solar atmosphere, jet-like events develop in many different environments, e.g., in the vicinity of active regions, as well as in coronal holes, and at various scales, from small photospheric spicules to large coronal jets. In all these events, signatures of helical structure and/or twisting/rotating motions are regularly observed. We aim to establish that a single model can generally reproduce the observed properties of these jet-like events. Methods: Using our state-of-the-art numerical solver ARMS, we present a parametric study of a numerical tridimensional magnetohydrodynamic (MHD) model of solar jet-like events. Within the MHD paradigm, we study the impact of varying the atmospheric plasma β on the generation and properties of solar-like jets. Results: The parametric study validates our model of jets for plasma β ranging from 10-3 to 1, typical of the different layers and magnetic environments of the solar atmosphere. Our model of jets can robustly explain the generation of helical solar jet-like events at various β ≤ 1. We introduces the new result that the plasma β modifies the morphology of the helical jet, explaining the different observed shapes of jets at different scales and in different layers of the solar atmosphere. Conclusions: Our results enable us to understand the energisation, triggering, and driving processes of jet-like events. Our model enables us to make predictions of the impulsiveness and energetics of jets as determined by the surrounding environment, as well as the morphological properties of the resulting jets.

  2. The First measurement of the top quark mass at CDF II in the lepton+jets and dilepton channels simultaneously

    SciTech Connect

    Aaltonen, T.; Adelman, J.; Akimoto, T.; Albrow, Michael G.; Alvarez Gonzalez, B.; Amerio, S.; Amidei, Dante E.; Anastassov, A.; Annovi, Alberto; Antos, J.; Apollinari, G.; /Fermilab /Purdue U.

    2008-09-01

    The authors present a measurement of the mass of the top quark using data corresponding to an integrated luminosity of 1.9 fb{sup -1} of p{bar p} collisions collected at {radical}s = 1.96 TeV with the CDF II detector at Fermilab's Tevatron. This is the first measurement of the top quark mass using top-antitop pair candidate events in the lepton + jets and dilepton decay channels simultaneously. They reconstruct two observables in each channel and use a non-parametric kernel density estimation technique to derive two-dimensional probability density functions from simulated signal and background samples. The observables are the top quark mass and the invariant mass of two jets from the W decay in the lepton + jets channel, and the top quark mass and the scalar sum of transverse energy of the event in the diletpon channel. They perform a simultaneous fit for the top quark mass and the jet energy scale, which is constrained in situ by the hadronic W boson mass. using 332 lepton + jets candidate events and 144 diletpon candidate events, they measure the top quark mass to be m{sub top} = 171.9 {+-} 1.7 (stat. + JES) {+-} 1.1 (other sys.) GeV/c{sup 2} = 171.9 {+-} 2.0 GeV/c{sup 2}.

  3. Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

    PubMed Central

    Yang, Bangkun; Ren, Qian; Ma, Min; Chen, Qian-Xue

    2016-01-01

    Background: Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression. Methods: The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stress model were examined. Results: In the tail suspension and forced swimming tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice. In the sucrose preference test, (+)-MK-801, but not (-)-MK-801, significantly enhanced reduced sucrose consumption 2 or 4 days after a single dose. However, no antianhedonia effects were detected 7 days after a single dose of either stereoisomer. Conclusions: Both stereoisomers of MK-801 induced rapid antidepressant effects in the social defeat stress model, although neither produced a long-lasting effect (7 days). PMID:27608811

  4. Measurement of the W Plus N Inclusive Jets Cross-Section at CDF Run II

    SciTech Connect

    Stentz, Dale James

    2012-01-01

    In this thesis we present the study of the production of the W boson in association with hadronic jets at the Collider Detector at Fermilab (CDF). Along with the electroweak properties the W boson, we examine jet kinematic variables with the aim of studying predictions of perturbative quantum chromodynamics. We derive several di erential crosssections as a function of the inclusive jet multiplicity and the transverse momenta of each jet. In this analysis, we are using 2.8 fb-1 of data and consider both the electron and muon lepton nal states for the W boson decay.

  5. PAGaN II: The Evolution of AGN Jets on Sub-Parsec Scales

    NASA Astrophysics Data System (ADS)

    Oh, Junghwan; Trippe, Sascha; Kang, Sincheol; Kim, Jae-Young; Park, Jong-Ho; Lee, Taeseok; Kim, Daewon; Kino, Motoki; Lee, Sang-Sung; Sohn, Bong Won

    2015-10-01

    We report first results from KVN and VERA Array (KaVA) VLBI observations obtained in the frame of our Plasma-physics of Active Galactic Nuclei (PAGaN) project. We observed eight selected AGN at 22 and 43 GHz in single polarization (LCP) between March 2014 and April 2015. Each source was observed for 6 to 8 hours per observing run to maximize the uv coverage. We obtained a total of 15 deep high-resolution images permitting the identification of individual circular Gaussian jet components and three spectral index maps of BL Lac, 3C~111 and 3C~345 from simultaneous dual-frequency observations. The spectral index maps show trends in agreement with general expectations -- flat core and steep jets -- while the actual value of the spectral index for jets shows indications for a dependence on AGN type. We analyzed the kinematics of jet components of BL Lac and 3C~111, detecting superluminal proper motions with maximum apparent speeds of about 5c. This constrains the lower limits of the intrinsic component velocities to ˜0.98c and the upper limits of the angle between jet and line of sight to ˜20°. In agreement with global jet expansion, jet components show systematically larger diameters d at larger core distances r, following the global relation d≈0.2r, albeit within substantial scatter.

  6. Development of a technique for inflight jet noise simulation. I, II

    NASA Technical Reports Server (NTRS)

    Clapper, W. S.; Stringas, E. J.; Mani, R.; Banerian, G.

    1976-01-01

    Several possible noise simulation techniques were evaluated, including closed circuit wind tunnels, free jets, rocket sleds and high speed trains. The free jet technique was selected for demonstration and verification. The first paper describes the selection and development of the technique and presents results for simulation and in-flight tests of the Learjet, F106, and Bertin Aerotrain. The second presents a theoretical study relating the two sets of noise signatures. It is concluded that the free jet simulation technique provides a satisfactory assessment of in-flight noise.

  7. A 20mK temperature sensor

    SciTech Connect

    Wang, N.; Sadoulet, B.; Shutt, T.; Beeman, J.; Haller, E.E.; Lange, A.; Park, I.; Ross, R.; Stanton, C.; Steiner, H.

    1987-11-01

    We are developing a 20mK temperature sensor made of neutron transmutation doped (NTD) germanium for use as a phonon detector in a dark matter search. We find that NTD germanium thermistors around 20mK have resistances which are a strong function of temperature, and have sufficient sensitivity to eventually reach a base line rms energy fluctuation of 6eV at 25mK. Further work is needed to understand the extreme sensitivity of the thermistors to bias power. 13 refs., 18 figs.

  8. Precise measurement of the top-quark mass in the lepton+jets topology at CDF II.

    PubMed

    Aaltonen, T; Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carrillo, S; Carlsmith, D; Carosi, R; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Cilijak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; DaRonco, S; Datta, M; D'Auria, S; Davies, T; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Dörr, C; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraan, A C; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuno, S; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vazquez, F; Velev, G; Vellidis, C; Veramendi, G; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-11-02

    We present a measurement of the mass of the top quark from proton-antiproton collisions recorded at the CDF experiment in Run II of the Fermilab Tevatron. We analyze events from the single lepton plus jets final state (tt-->W(+)bW(-)b-->lnubqq'b). The top-quark mass is extracted using a direct calculation of the probability density that each event corresponds to the tt final state. The probability is a function of both the mass of the top quark and the energy scale of the calorimeter jets, which is constrained in situ by the hadronic W boson mass. Using 167 events observed in 955 pb(-1) of integrated luminosity, we achieve the single most precise measurement of the top-quark mass, 170.8+/-2.2(stat.)+/-1.4(syst.) GeV/c(2).

  9. Synchrotron and inverse-Compton emission from blazar jets - II. An accelerating jet model with a geometry set by observations of M87

    NASA Astrophysics Data System (ADS)

    Potter, William J.; Cotter, Garret

    2013-02-01

    In this paper we develop the jet model of Potter & Cotter to include a magnetically dominated accelerating parabolic base transitioning to a slowly decelerating conical jet with a geometry set by recent radio observations of M87. We conserve relativistic energy-momentum and particle number along the jet and calculate the observed synchrotron emission from the jet by calculating the integrated line-of-sight synchrotron opacity through the jet in the rest frame of each section of plasma. We calculate the inverse-Compton emission from synchrotron, cosmic microwave background (CMB), accretion disc, starlight, broad-line region (BLR), dusty torus and narrow-line region photons by transforming into the rest frame of the plasma along the jet. We fit our model to simultaneous multi-wavelength observations of the Compton-dominant FSRQ type blazar PKS 0227-369, with a jet geometry set by M87 and an accelerating bulk Lorentz factor consistent with simulations and theory. We investigate models in which the jet comes into equipartition at different distances along the jet and equipartition is maintained via the conversion of jet bulk kinetic energy into particle acceleration. We find that the jet must still be magnetically dominated within the BLR and cannot be in equipartition due to the severe radiative energy losses. The model fits the observations, including radio data, very well if the jet comes into equipartition outside the BLR within the dusty torus (1.5 pc) or at further distances (34 pc). The fits require a high-power jet with a large bulk Lorentz factor observed close to the line of sight, consistent with our expectations for a Compton-dominant blazar. We find that our fit in which the jet comes into equipartition furthest along the jet, which has a jet with the geometry of M87 scaled linearly with black hole mass, has an inferred black hole mass close to previous estimates. This implies that the jet of PKS 0227 might be well described by the same jet geometry as M87.

  10. Development and testing of a high-pressure downhole pump for jet-assist drilling. Topical report, Phase II

    SciTech Connect

    1997-10-01

    The goal of jet-assisted drilling is to increase the rate of penetration (ROP) in deeper gas and oil wells, where the rocks become harder and more difficult to drill. Increasing the ROP can result in fewer drilling days, and therefore, lower drilling cost. In late 1993, FlowDril and the Gas Research Institute (GRI) began a three-year development of a down hole pump (DHP{reg_sign}) capable of producing 30,000 psi out pressure to provide the high-pressure flow for high-pressure jet-assist of the drill bit. The U.S. Department of Energy (DOE) through its Morgantown, WV (DOE-Morgantown) field office, joined with GRI and FlowDril to develop and test a second prototype designed for drilling in 7-7/8 inch holes. This project, {open_quotes}Development and Testing of a High-Pressure Down Hole Pump for Jet-Assist Drilling,{close_quotes} is for the development and testing of the second prototype. It was planned in two phases. Phase I included an update of a market analysis, a design, fabrication, and an initial laboratory test of the second prototype. Phase II is continued iterative laboratory and field developmental testing. This report summarizes the results of Phase II. In the downhole pump approach shown in the following figure, conventional drill pipe and drill collars are used, with the DHP as the last component of the bottom hole assembly next to the bit. The DHP is a reciprocating double ended, intensifier style positive displacement, high-pressure pump. The drive fluid and the high-pressure output fluid are both derived from the same source, the abrasive drilling mud pumped downhole through the drill string. Approximately seven percent of the stream is pressurized to 30,000 psi and directed through a high-pressure nozzle on the drill bit to produce the high speed jet and assist the mechanical action of the bit to make it drill faster.

  11. Studies of the Jet in Bl Lacertae. II. Superluminal Alfvén Waves

    NASA Astrophysics Data System (ADS)

    Cohen, M. H.; Meier, D. L.; Arshakian, T. G.; Clausen-Brown, E.; Homan, D. C.; Hovatta, T.; Kovalev, Y. Y.; Lister, M. L.; Pushkarev, A. B.; Richards, J. L.; Savolainen, T.

    2015-04-01

    We study the kinematics of ridge lines on the parsec-scale jet of the active galactic nucleus BL Lacertae. We show that the ridge lines display transverse patterns that move superluminally downstream, and that the moving patterns are analogous to waves on a whip. Their apparent speeds β app (units of c) range from 3.9 to 13.5, corresponding to {β }{wave}{gal}=0.981-0.998 in the galaxy frame. We show that the magnetic field in the jet is well ordered with a strong transverse component, and assume that it is helical and that the transverse patterns are Alfvén waves propagating downstream on the longitudinal component of the magnetic field. The wave-induced transverse speed of the jet is non-relativistic ({β }{tr}{gal}≲ 0.09). In 2010 the wave activity subsided and the jet then displayed a mild wiggle that had a complex oscillatory behavior. The Alfvén waves appear to be excited by changes in the position angle of the recollimation shock, in analogy to exciting a wave on a whip by shaking the handle. A simple model of the system with plasma sound speed β s = 0.3 and apparent speed of a slow MHD wave β app, S = 4 yields Lorentz factor of the beam Γbeam ∼ 4.5, pitch angle of the helix (in the beam frame) α ∼ 67°, Alfvén speed β A ∼ 0.64, and magnetosonic Mach number M ms ∼ 4.7. This describes a plasma in which the magnetic field is dominant and in a rather tight helix, and Alfvén waves are responsible for the moving transverse patterns.

  12. Altitude-chamber performance of British Rolls-Royce Nene II engine III : 18.00-inch-diameter jet nozzle

    NASA Technical Reports Server (NTRS)

    Grey, Ralph E; Brightwell, Virginia L; Barson, Zelmar; NACA

    1950-01-01

    An altitude-chamber investigation of British Rolls-Royce Nene II turbojet engine was conducted over range of altitudes from sea level to 65,000 feet and ram pressure ratios from 1.10 to 3.50, using an 18.00-inch-diameter jet nozzle. The 18.00-inch-diameter jet nozzle gave slightly lower values of net-thrust specific fuel consumption than either the 18.41- or the standard 18.75-inch-diameter jet nozzles at high flight speeds. At low flight speeds, the 18.41-inch-diameter jet nozzle gave the lowest value of net-thrust specific fuel consumption.

  13. The 5-6 December 1991 FIRE IFO II jet stream cirrus case study: Possible influences of Volcanic Aerosols

    NASA Technical Reports Server (NTRS)

    Sassen, Kenneth; Starr, David O'C.; Mace, Gerald G.; Poellot, Michael R.; Melfi, S. H.; Eberhard, Wynn L.; Spinhirne, James D.; Eloranta, E. W.; Hagen, Donald E.; Hallett, John

    1995-01-01

    In presenting an overview of the cirus clouds comprehensively studied by ground-based and airborne sensors from Coffeyville, Kansas, during the 5-6 December 1992 Project First ISCCP Region Experiment (FIRE) Intensive Fields Observation (IFO) II case study period, evidence is provided that volcanic aerosols friom the June 1991 Pinatubo eruptions may have significantly influenced the formation and maintenance of the cirrus. Following the local appearance of a spur of stratospheric volcanic debris from the subtropics, a series of jet streaks subsequently conditioned the troposphere through tropopause foldings with sulfur-based particles that became effective cloud-forming nuclei in cirrus clouds. Aerosol and ozone measurements suggest a complicated history of stratospheric-tropospheric exchanges embedded within the upper-level flow, and cirrus cloud formation was noted to occur locally at the boundaries of stratospheric aerosol-enriched layers that became humidified through diffusion, precipitation, or advective processes. Apparent cirrus cloud alterations include abnormally high ice crystal concentrations (up to approximately 600/L), complex radial ice crystal types, and relatively large haze particles in cirrus uncinus cell heads at temperatures between -40 and -50 C. Implications for volcanic-cirrus cloud climate effects and usual (nonvolcanic aerosol) jet stream cirrus cloud formation are discussed.

  14. Class II combination therapy (distal jet and Jasper Jumpers): a case report.

    PubMed

    Bowman, S J

    2000-09-01

    Class II combination therapy is a method that combines orthodontic and orthopedic mechanics in a single stage of treatment. Molar distalization is followed by fixed functional mechanics to reduce the dependence upon patient compliance while seeking more predictable completion of Class II correction.

  15. Measurement of the WW + WZ production cross section using the lepton + jets final state at CDF II.

    PubMed

    Aaltonen, T; Adelman, J; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'Orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; d'Errico, M; Di Canto, A; di Giovanni, G P; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Dube, S; Ebina, K; Elagin, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Hughes, R E; Hurwitz, M; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Lovas, L; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramanov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Simonenko, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Suh, J S; Sukhanov, A; Suslov, I; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wolfe, H; Wright, T; Wu, X; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhang, X; Zheng, Y; Zucchelli, S

    2010-03-12

    We report two complementary measurements of the WW + WZ cross section in the final state consisting of an electron or muon, missing transverse energy, and jets, performed using pp collision data at square root of s = 1.96 TeV collected by the CDF II detector. The first method uses the dijet invariant mass distribution while the second more sensitive method uses matrix-element calculations. The result from the second method has a signal significance of 5.4sigma and is the first observation of WW + WZ production using this signature. Combining the results gives sigma(WW + WZ) = 16.0 +/- 3.3 pb, in agreement with the standard model prediction.

  16. Measurement of the WW+WZ Production Cross Section Using the lepton+jets Final State at CDF II

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Beecher, D.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Calancha, C.; Camarda, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Chung, K.; Chung, W. H.; Chung, Y. S.; Chwalek, T.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Crescioli, F.; Cuenca Almenar, C.; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lorenzo, G.; Dell'Orso, M.; Deluca, C.; Demortier, L.; Deng, J.; Deninno, M.; D'Errico, M.; di Canto, A.; di Giovanni, G. P.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Dorigo, T.; Dube, S.; Ebina, K.; Elagin, A.; Erbacher, R.; Errede, D.; Errede, S.; Ershaidat, N.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Frank, M. J.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerdes, D.; Gessler, A.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; Guimaraes da Costa, J.; Gunay-Unalan, Z.; Haber, C.; Hahn, S. R.; Halkiadakis, E.; Han, B.-Y.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harr, R. F.; Hartz, M.; Hatakeyama, K.; Hays, C.; Heck, M.; Heinrich, J.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Hughes, R. E.; Hurwitz, M.; Husemann, U.; Hussein, M.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jha, M. K.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Ketchum, W.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, H. W.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kuhr, T.; Kulkarni, N. P.; Kurata, M.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, E.; Lee, H. S.; Lee, J. S.; Lee, S. W.; Leone, S.; Lewis, J. D.; Lin, C.-J.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, T.; Lockyer, N. S.; Loginov, A.; Lovas, L.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Mastrandrea, P.; Mathis, M.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzione, A.; Mesropian, C.; Miao, T.; Mietlicki, D.; Miladinovic, N.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moed, S.; Moggi, N.; Mondragon, M. N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlock, J.; Movilla Fernandez, P.; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Neubauer, M. S.; Neubauer, S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Osterberg, K.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramanov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Peiffer, T.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Potamianos, K.; Poukhov, O.; Prokoshin, F.; Pronko, A.; Ptohos, F.; Pueschel, E.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Renton, P.; Renz, M.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Rutherford, B.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Santi, L.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, A.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sforza, F.; Sfyrla, A.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shiraishi, S.; Shochet, M.; Shon, Y.; Shreyber, I.; Simonenko, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soha, A.; Somalwar, S.; Sorin, V.; Squillacioti, P.; Stanitzki, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Strycker, G. L.; Suh, J. S.; Sukhanov, A.; Suslov, I.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thome, J.; Thompson, G. A.; Thomson, E.; Tipton, P.; Ttito-Guzmán, P.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Tourneur, S.; Trovato, M.; Tsai, S.-Y.; Tu, Y.; Turini, N.; Ukegawa, F.; Uozumi, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Vidal, M.; Vila, I.; Vilar, R.; Vogel, M.; Volobouev, I.; Volpi, G.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner, W.; Wagner-Kuhr, J.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Weinelt, J.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Wilbur, S.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wolfe, H.; Wright, T.; Wu, X.; Würthwein, F.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanetti, A.; Zeng, Y.; Zhang, X.; Zheng, Y.; Zucchelli, S.; CDF Collaboration

    2010-03-01

    We report two complementary measurements of the WW+WZ cross section in the final state consisting of an electron or muon, missing transverse energy, and jets, performed using pp¯ collision data at s=1.96TeV collected by the CDF II detector. The first method uses the dijet invariant mass distribution while the second more sensitive method uses matrix-element calculations. The result from the second method has a signal significance of 5.4σ and is the first observation of WW+WZ production using this signature. Combining the results gives σWW+WZ=16.0±3.3pb, in agreement with the standard model prediction.

  17. Dichotomy of Solar Coronal Jets: Standard Jets and Blowout Jets

    NASA Astrophysics Data System (ADS)

    Moore, Ronald L.; Cirtain, Jonathan W.; Sterling, Alphonse C.; Falconer, David A.

    2010-09-01

    By examining many X-ray jets in Hinode/X-Ray Telescope coronal X-ray movies of the polar coronal holes, we found that there is a dichotomy of polar X-ray jets. About two thirds fit the standard reconnection picture for coronal jets, and about one third are another type. We present observations indicating that the non-standard jets are counterparts of erupting-loop Hα macrospicules, jets in which the jet-base magnetic arch undergoes a miniature version of the blowout eruptions that produce major coronal mass ejections. From the coronal X-ray movies we present in detail two typical standard X-ray jets and two typical blowout X-ray jets that were also caught in He II 304 Å snapshots from STEREO/EUVI. The distinguishing features of blowout X-ray jets are (1) X-ray brightening inside the base arch in addition to the outside bright point that standard jets have, (2) blowout eruption of the base arch's core field, often carrying a filament of cool (T ~ 104 - 105 K) plasma, and (3) an extra jet-spire strand rooted close to the bright point. We present cartoons showing how reconnection during blowout eruption of the base arch could produce the observed features of blowout X-ray jets. We infer that (1) the standard-jet/blowout-jet dichotomy of coronal jets results from the dichotomy of base arches that do not have and base arches that do have enough shear and twist to erupt open, and (2) there is a large class of spicules that are standard jets and a comparably large class of spicules that are blowout jets.

  18. Dichotomy of Solar Coronal Jets: Standard Jets and Blowout Jets

    NASA Technical Reports Server (NTRS)

    Moore, R. L.; Cirtain, J. W.; Sterling, A. C.; Falconer, D. A.

    2010-01-01

    By examining many X-ray jets in Hinode/XRT coronal X-ray movies of the polar coronal holes, we found that there is a dichotomy of polar X-ray jets. About two thirds fit the standard reconnection picture for coronal jets, and about one third are another type. We present observations indicating that the non-standard jets are counterparts of erupting-loop H alpha macrospicules, jets in which the jet-base magnetic arch undergoes a miniature version of the blowout eruptions that produce major CMEs. From the coronal X-ray movies we present in detail two typical standard X-ray jets and two typical blowout X-ray jets that were also caught in He II 304 Angstrom snapshots from STEREO/EUVI. The distinguishing features of blowout X-ray jets are (1) X-ray brightening inside the base arch in addition to the outside bright point that standard jets have, (2) blowout eruption of the base arch's core field, often carrying a filament of cool (T 10(exp 4) - 10(exp 5) K) plasma, and (3) an extra jet-spire strand rooted close to the bright point. We present cartoons showing how reconnection during blowout eruption of the base arch could produce the observed features of blowout X-ray jets. We infer that (1) the standard-jet/blowout-jet dichotomy of coronal jets results from the dichotomy of base arches that do not have and base arches that do have enough shear and twist to erupt open, and (2) there is a large class of spicules that are standard jets and a comparably large class of spicules that are blowout jets.

  19. DICHOTOMY OF SOLAR CORONAL JETS: STANDARD JETS AND BLOWOUT JETS

    SciTech Connect

    Moore, Ronald L.; Cirtain, Jonathan W.; Sterling, Alphonse C.; Falconer, David A.

    2010-09-01

    By examining many X-ray jets in Hinode/X-Ray Telescope coronal X-ray movies of the polar coronal holes, we found that there is a dichotomy of polar X-ray jets. About two thirds fit the standard reconnection picture for coronal jets, and about one third are another type. We present observations indicating that the non-standard jets are counterparts of erupting-loop H{alpha} macrospicules, jets in which the jet-base magnetic arch undergoes a miniature version of the blowout eruptions that produce major coronal mass ejections. From the coronal X-ray movies we present in detail two typical standard X-ray jets and two typical blowout X-ray jets that were also caught in He II 304 A snapshots from STEREO/EUVI. The distinguishing features of blowout X-ray jets are (1) X-ray brightening inside the base arch in addition to the outside bright point that standard jets have, (2) blowout eruption of the base arch's core field, often carrying a filament of cool (T {approx} 10{sup 4} - 10{sup 5} K) plasma, and (3) an extra jet-spire strand rooted close to the bright point. We present cartoons showing how reconnection during blowout eruption of the base arch could produce the observed features of blowout X-ray jets. We infer that (1) the standard-jet/blowout-jet dichotomy of coronal jets results from the dichotomy of base arches that do not have and base arches that do have enough shear and twist to erupt open, and (2) there is a large class of spicules that are standard jets and a comparably large class of spicules that are blowout jets.

  20. Preliminary Results of Nene II Engine Altitude-chamber Performance Investigation. 2; Altitude Performance using 18.41-inch Diameter-jet Nozzle

    NASA Technical Reports Server (NTRS)

    Armstron, J. C.; Wilsted, H. D.; Vincent, K. R.

    1948-01-01

    An investigation is being conducted to determine the altitude performance characteristics of the Nene II engine and its components. The present paper presents preliminary results obtained using a jet nozzle of 18.41 inches in diameter, giving an area equal to 96.4 percent of the area of the standard jet nozzle of this engine. The test results presented are for conditions simulating altitudes from seal level to 50,000 feet and ram-pressure ratios from 1.00 to 2.70. The ram pressure ratios correspond to flight Mach numbers between zero and 1.28.

  1. Aerodynamic Loads and Separation Characteristics of the BLU-27B/B, MK- 82SE, and GBU-8 Weapons in the F-16 Aircraft Flow Field at Mach Numbers from 0.4 to 1.2

    DTIC Science & Technology

    1976-10-01

    76-147 Cm 1.2 0.8 o.q 0 SIMBOL CONFIG = ~ STORE ® IS E 0.60 MK-SESE m 15 E 0.80 MK-SESE IS E 0.90 MK-82SE IS E 0.95 MK-B2SE PYLON RRCK 6 M...0 10 .0 1 2 6 A E D C - T R - 7 6 - 1 4 7 SIMBOL CONFIG = H. STORE PILON RICK ~tt 0 11 I0 0.80 MK-82SE 7 I - 3 0 B II 10 0.60 HR-B2SE 7 T

  2. Emerging jets

    NASA Astrophysics Data System (ADS)

    Schwaller, Pedro; Stolarski, Daniel; Weiler, Andreas

    2015-05-01

    In this work, we propose a novel search strategy for new physics at the LHC that utilizes calorimeter jets that (i) are composed dominantly of displaced tracks and (ii) have many different vertices within the jet cone. Such emerging jet signatures are smoking guns for models with a composite dark sector where a parton shower in the dark sector is followed by displaced decays of dark pions back to SM jets. No current LHC searches are sensitive to this type of phenomenology. We perform a detailed simulation for a benchmark signal with two regular and two emerging jets, and present and implement strategies to suppress QCD backgrounds by up to six orders of magnitude. At the 14 TeV LHC, this signature can be probed with mediator masses as large as 1.5 TeV for a range of dark pion lifetimes, and the reach is increased further at the high-luminosity LHC. The emerging jet search is also sensitive to a broad class of long-lived phenomena, and we show this for a supersymmetric model with R-parity violation. Possibilities for discovery at LHCb are also discussed.

  3. Mass and momentum turbulent transport experiments with swirling confined coaxial jets. II

    NASA Technical Reports Server (NTRS)

    Roback, R.; Johnson, B. V.

    1986-01-01

    An experimental study of mixing downstream of swirling coaxial jets discharging into an expanded duct was conducted to obtain data for the evaluation and improvement of turbulent transport models currently used in a variety of computational procedures throughout the combustion community. A combination of laser velocimeter and laser induced fluorescence techniques was employed to obtain mean and fluctuating velocity and concentration distributions at selected axial and radial locations throughout the flow field. Flow visualization techniques were also employed to determine qualitatively the time dependent characteristics of the flow and the scale of turbulence. Simultaneous two component velocity and concentration/velocity measurements provided data which were used to determine the average momentum and mass transport rates for each of three measurement planes. Mixing for swirling flows occurred in several steps of axial and radial mean convective flow and was completed in one-third the length required for nonswirling flow. Comparison of the mass and momentum transport processes for swirling and nonswirling flows indicated that large differences existed in these processes between the two flows.

  4. [Fe II] 1.64 μm FEATURES OF JETS AND OUTFLOWS FROM YOUNG STELLAR OBJECTS IN THE CARINA NEBULA

    SciTech Connect

    Shinn, Jong-Ho; Lee, Jae-Joon; Chun, Moo-Young; Lyo, A.-Ran; Moon, Dae-Sik; Kyeong, Jaemann; Park, Byeong-Gon; Pyo, Tae-Soo; Lee, Ho-Gyu; Kim, Hyun-Jeong; Koo, Bon-Chul; Lee, Yong-Hyun; Sung, Hwankyung; Hur, Hyeonoh

    2013-11-01

    We present [Fe II] 1.64 μm imaging observations for jets and outflows from young stellar objects (YSOs) over the northern part (∼24' × 45') of the Carina Nebula, a massive star-forming region. The observations were performed with IRIS2 of the Anglo-Australian Telescope and the seeing was ∼1.''5 ± 0.''5. Eleven jet and outflow features are detected at eight different regions and are termed ionized Fe objects (IFOs). One Herbig-Haro candidate that was missed in Hubble Space Telescope Hα observations is newly identified as HHc-16, referring to our [Fe II] images. IFOs have knotty or longish shapes, and the detection rate of IFOs against previously identified YSOs is 1.4%, which should be treated as a lower limit. Four IFOs show anti-correlated peak intensities in [Fe II] and Hα, where the ratio I([Fe II])/I(Hα) is higher for longish IFOs than for knotty IFOs. We estimate the outflow mass loss rate from the [Fe II] flux using two different methods. The jet-driving objects are identified for three IFOs (IFO-2, -4, and -7) for which we study the relations between the outflow mass loss rate and the YSO physical parameters from the radiative transfer model fitting. The ratios of the outflow mass loss rate over the disk accretion rate for IFO-4 and -7 are consistent with the previously reported values (10{sup –2}-10{sup +1}), while the ratio is higher for IFO-2. This excess may result from underestimating the disk accretion rate. The jet-driving objects are likely to be low- or intermediate-mass stars. Other YSO physical parameters, such as luminosity and age, show reasonable relations or trends.

  5. The jovian anticyclone BA. II. Circulation and interaction with the zonal jets

    NASA Astrophysics Data System (ADS)

    Hueso, R.; Legarreta, J.; García-Melendo, E.; Sánchez-Lavega, A.; Pérez-Hoyos, S.

    2009-10-01

    In this second part of our study of the large jovian anticyclone BA we present detailed measurements of its internal circulation and numerical models of its interaction with the zonal jets and nearby cyclonic regions. We characterized the flow using high-resolution observations obtained by the Cassini spacecraft in December 2000 (9 months after the genesis of BA as a result of the merger of two large White Ovals), by the ACS camera onboard HST in January 2005 and April 2006 and by the New Horizons spacecraft in February 2007. Cloud motions were derived from high-resolution images using an automatic correlator that provides a large sampling of the motions in images separated by short time intervals (30 min-2 h). The internal wind structure did not change when the oval changed its color reddening in late 2005-early 2006 and all four datasets from 2000 to 2007 consistently show a similar wind regime: an asymmetric intense anticyclonic vortex with faster winds in its Southern portion with mean speeds of 110 m/s and peak velocities of 135 m/s. These speeds are slightly higher than those measured in the three White Ovals predecessors of BA by the Voyagers [Mitchell, J.L., Beebe, R.F., Ingersoll, A.P., Garneau, G.W., 1981. J. Geophys. Res. 86, 8751-8757] and Galileo [Vasavada, A.R., and 13 colleagues, 1998. Icarus 135, 265-275] but not as much as it has been recently reported [Simon-Miller, A.A., Chanover, N.J., Orton, G.S., Sussman, M., Tsavaris, I.G., Karkoschka, E., 2006. Icarus 185, 558-562; Cheng, A.F., and 14 colleagues, 2008. Astronom. J. 135, 2446-2452]. The asymmetry of the velocities in the vortex is a consequence of the interaction of BA with the zonal circulation and emerges as a natural result in high-resolution simulations of the vortex dynamics using the EPIC model.

  6. Development of the Mk-112 Detonator

    DTIC Science & Technology

    1982-12-01

    This is within 10 % of the reported value for the Mk 57-1 of 27.6 volts ( 14283 ergs). Therefore, the design goal of similar firing energy...Code R12) White Oak, Silver Spring, Maryland 20910 10 . PROGRAM ELEMENT, PROJECT, TASK AREA 4 WORK UNIT NUMBERS 64601N-QUICKSTRIKE- 52072...CURED AT 70 F FOR 72 HOURS) 10 5 AVERAGE RESISTANCE CHANGE (LEADS-TO-CASE) VS. TIME TO CURE. (ELECTRODAG CURED AT 180OF FOR 24 HOURS) 11 6

  7. Quiet-time statistics of electrostatic turbulent fluxes from the JET tokamak and the W7-AS and TJ-II stellarators.

    PubMed

    Sánchez, R; van Milligen, B Ph; Newman, D E; Carreras, B A

    2003-05-09

    The statistics of the quiet times between successive turbulent flux bursts measured at the edge of the JET tokamak and the W7-AS and TJ-II stellarators are analyzed in search for evidence of self-organized critical behavior. The results obtained are consistent with what would be expected in the situation where the underlying plasma is indeed in a near critical state.

  8. Effect of the Angiotensin I Converting Enzyme Inhibitor, MK-421, on Experimentally Induced Drinking

    NASA Technical Reports Server (NTRS)

    Fregley, Melvin J.; Fater, Dennis C.; Greenleaf, John E.

    1982-01-01

    MK-421, the ethyl ester maleate salt of N-(S)-1-(ethoxycarbonyl)-3-phenyl-propyl- Ala-L-Pro, is an angiotensin I converting enzyme inhibitor. An initial objective was to determine whether MK-421, administered at 0, 2.5, 5.0, 10.0, 20.0 and 40.0 mg/kg, ip to 96 female rats 15 min prior to administration of the beta-adrenergic agonist, isoproterenol (25 microgram/kg, ip), would inhibit the drinking induced by isoproterenol during 2 h after its administration. The water intake induced by isoproterenol was inhibited significantly by 2.5 mg MK-421/kg. When a similar experiment was performed using Angiotensin I (AI) (200 microgram/kg, ip) as the dipsogenic agent, MK-421 (5 mg/kg, ip), administered 15 min prior to AI, inhibited significantly both the dipsogenic and the diuretic effect of AI. However, administration of angiotensin II (AII, 200 microgram/kg, ip) 15 min after MK-421 (5mg/kg) was accompanied by a water intake that did not differ from AII alone. The drink induced by ip administration of 1.0 m NaCl solution (1% of body wt, ip) was not inhibited by administration of MK-421 (5 mg/kg) 15 min prior to allowing access to water while the drink induced by a 24 h dehydration was partially inhibited. Thus, the drinks induced by administraition of either isoproterenol or AI are dependent on formation of AII. That induced by dehydration is partially dependent, while that induced by hypertonic siilinc is independent of the formation of AII.

  9. SU2C Phase Ib Study of Paclitaxel and MK-2206 in Advanced Solid Tumors and Metastatic Breast Cancer

    PubMed Central

    Gonzalez-Angulo, Ana M.; Krop, Ian; Akcakanat, Argun; Chen, Huiqin; Liu, Shuying; Li, Yisheng; Culotta, Kirk S.; Tarco, Emily; Piha-Paul, Sarina; Moulder-Thompson, Stacy; Velez-Bravo, Vivianne; Sahin, Aysegul A.; Doyle, Laurence A.; Do, Kim-Anh; Winer, Eric P.; Mills, Gordon B.; Kurzrock, Razelle

    2015-01-01

    Background: There is preclinical synergism between taxanes and MK-2206. We aim to determine the maximum tolerated dose, safety, and activity of combining MK-2206 and paclitaxel in metastatic cancer. Methods: Patients received weekly doses of paclitaxel at 80mg/m2 on day 1, followed by MK-2206 orally on day 2 escalated at 90mg, 135mg, and 200mg. Treatment continued until progression, excessive toxicity, or patient request. Blood and tissue were collected for pharmacokinetic and pharmacodynamics markers. A cycle consisted of three weeks of therapy. Dose-limiting toxicity (DLT) was defined as unacceptable toxicity during the first cycle. All statistical tests were two-sided. Results: Twenty-two patients were treated, nine in dose escalation and 13 in dose expansion. Median age was 55 years. Median number of cycles was four. Dose escalation was completed with no DLT. CTCAE Grade 3 or higher adverse events were fatigue (n = 2), rash (n = 2), hyperglycemia (n = 1), and neutropenia (n = 7). Four patients in the expansion phase required MK-2206 dose reduction. Phase II recommended dose was established as paclitaxel 80mg/m2 weekly on day 1, and MK-2206 135mg weekly on day 2. Paclitaxel systemic exposure was similar in the presence or absence of MK-2206. Plasma MK-2206 concentrations were similar to data from previous phase I monotherapy. There was a statistically significant decrease in expression of pAKT S473 (P = .01) and pAKT T308 (P = .002) after therapy. PI3K/AKT/mTOR downregulation in tumor tissues and circulating markers did not correlate with tumor response or clinical benefit. There were five objective responses, and nine patients had stable disease. Conclusion: MK-2206 was well tolerated with paclitaxel. Preliminary antitumor activity was documented. PMID:25688104

  10. Bioavailability and Chemical/Functional Aspects of Synthetic MK-7 vs Fermentation-Derived MK-7 in Randomised Controlled Trials.

    PubMed

    Møller, Mona; Gjelstad, Ingrid M Fange; Baksaas, Ingebjørg; Grande, Tone; Aukrust, Inger Reidun; Drevon, Christian A

    2016-07-04

    We investigated the bioavailability of a synthetic form of the vitamin K2 molecule menaquinone-7 (MK-7) in a randomised single-blinded two-way cross-over study. Healthy subjects (20 - 66 years of age) took a single 180 μg dose of synthetic MK-7 or fermentation-derived MK-7, and serum MK-7 concentrations were monitored for 72 hours to calculate AUC(0 - 72 h) and Cmax. We also compared the biological effects of placebo, fermentation-derived MK-7 (90 μg) and 3 doses of synthetic MK-7(45, 90 and 180 μg) in a randomised double-blinded parallel study. Healthy subjects (20 - 60 years of age) took one of the supplements daily for 43 days, and the fraction of carboxylated osteocalcin (OC) was compared between day 1 and day 43 as a marker for vitamin K activity. In the bioavailability study, the 90 % confidence interval for the ratio of the AUC(0-72 h) values for synthetic and fermentationderived MK-7 was 83 - 111, indicating bioequivalence. The 90 % confidence interval for the Cmax ratio was 83 - 131. The serum concentrations of carboxylated OC and undercarboxylated OC were increased (p = 0.01) and reduced (p = 0.02), respectively, after daily intake of 180 μg of synthetic MK-7 for 43 days, indicating increased vitamin K activity. Across both studies, only 1 participant reported an adverse event (dry mouth; 180 μg synthetic MK-7 group, functional study) that was considered possibly related to synthetic MK-7 supplementation. Our findings provide evidence that the tested synthetic form of MK-7 is bioequivalent to fermentation-derived MK-7, exhibits vitamin K activity and is well tolerated in healthy subjects.

  11. A Case Study of the MK 16 MOD O Underwater Breathing Apparatus Program

    DTIC Science & Technology

    1989-06-01

    7 COS4aII CODES 18 SuBEC T LERMS Contrinue on reverse it ne(csay and ,dvnrjt1 b) block number) FIELD GRO)P SIUBGROUP Explosive Ordnance...protection the mission profile of the MK 16 would be severely restricted. 27 The NAVEODTECHCEN pier on the Potomac River was chosen as the T&E site due to its

  12. Gas Jets

    NASA Technical Reports Server (NTRS)

    Chaplygin, S.

    1944-01-01

    A brief summary of the contents of this paper is presented here. In part I the differential equations of the problem of a gas flow in two dimensions is derived and the particular integrals by which the problem on jets is solved are given. Use is made of the same independent variables as Molenbroek used, but it is found to be more suitable to consider other functions. The stream function and velocity potential corresponding to the problem are given in the form of series. The investigation on the convergence of these series in connection with certain properties of the functions entering them forms the subject of part II. In part III the problem of the outflow of a gas from an infinite vessel with plane walls is solved. In part IV the impact of a gas jet on a plate is considered and the limiting case where the jet expands to infinity changing into a gas flow is taken up in more detail. This also solved the equivalent problem of the resistance of a gaseous medium to the motion of a plate. Finally, in part V, an approximate method is presented that permits a simpler solution of the problem of jet flows in the case where the velocities of the gas (velocities of the particles in the gas) are not very large.

  13. Search for Anomalous Production of Photon + Jets + Missing Transverse Energy in $p\\bar{p}$ Collisions at $\\sqrt{s}=1.96$~TeV Using the CDF II Detector

    SciTech Connect

    Hewamanage, Samantha Kaushalya

    2011-01-01

    A model-independent signature-based search for physics beyond the Standard Model is performed in the photon + jets + missing transverse energy channel in \\ppbar collisions at a center of mass energy of 1.96 TeV using the CDF II detector. Events with a photon + jets are predicted by the Standard Model and also by many theoretical models beyond the Standard Model. In the Standard Model, the main mechanisms for photon + jets production include quark-antiquark annihilation and quark-gluon scattering. No intrinsic missing transverse energy is present in any of these Standard Model processes. In this search, photon + $\\geq$1 jet and photon + $\\geq$2 jet events are analyzed with and without a minimum requirement on the missing transverse energy. Numerous mass distributions and kinematic distributions are studied and no significant excess over the background prediction is found. All results indicate good agreement with expectations of the Standard Model.

  14. Measurement of the Inclusive Jet Cross Section using the k(T) algorithm in p anti-p collisions at s**(1/2) = 1.96-TeV with the CDF II Detector

    SciTech Connect

    Abulencia, A.; Adelman, J.; Affolder, Anthony Allen; Akimoto, T.; Albrow, Michael G.; Ambrose, D.; Amerio, S.; Amidei, Dante E.; Anastassov, A.; Anikeev, Konstantin; Annovi, A.; /Frascati /Comenius U.

    2007-01-01

    The authors report on measurements of the inclusive jet production cross section as a function of the jet transverse momentum in p{bar p} collisions at {radical}s = 1.96 TeV, using the k{sub T} algorithm and a data sample corresponding to 1.0 fb{sup -1} collected with the Collider Detector at Fermilab in Run II. The measurements are carried out in five different jet rapidity regions with |y{sup jet}| < 2.1 and transverse momentum in the range 54 < p{sub T}{sup jet} < 700 GeV/c. Next-to-leading order perturbative QCD predictions are in good agreement with the measured cross sections.

  15. Twin Jet

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda; Bozak, Rick

    2010-01-01

    Many subsonic and supersonic vehicles in the current fleet have multiple engines mounted near one another. Some future vehicle concepts may use innovative propulsion systems such as distributed propulsion which will result in multiple jets mounted in close proximity. Engine configurations with multiple jets have the ability to exploit jet-by-jet shielding which may significantly reduce noise. Jet-by-jet shielding is the ability of one jet to shield noise that is emitted by another jet. The sensitivity of jet-by-jet shielding to jet spacing and simulated flight stream Mach number are not well understood. The current experiment investigates the impact of jet spacing, jet operating condition, and flight stream Mach number on the noise radiated from subsonic and supersonic twin jets.

  16. Impingement heat transfer within arrays of circular jets. II - Effects of crossflow in the presence of roughness elements

    NASA Astrophysics Data System (ADS)

    Trabold, T. A.; Obot, N. T.

    1987-05-01

    An experimental investigation was carried out to determine the effects of jet-induced crossflow on impingement heat transfer from rough surfaces. The jets impinged on surfaces having repeated square ribs, with transverse flow of the spent air. Two crossflow schemes were tested: discharge of the spent air through two opposite sides (intermediate crossflow) and through one side (complete or maximum crossflow) of the rectangular impingement surface. The rib height was fixed at 0.813 mm, while the pitch-to-height ratio (p/e) was varied between 6 and 10. The study covered standoff spacing and jet Reynolds number in the range 2 to 16 jet hole diameters and, 1300 to 21,000, respectively. Three nozzle plates, having 48, 90 and 180 square-edged holes, were tested. For the maximum crossflow scheme, the presence of roughness results in small upstream reductions in heat transfer coefficient, with marked improvement in the downstream section; indicating that roughness elements can be used to compensate for the degradation that is usually associated with impingement on smooth surfaces.

  17. Manned Certification Tests of the Modernized MK 16 MOD 1

    DTIC Science & Technology

    2013-11-01

    the UBA inspiratory hose. Twenty-four divers using six modernized MK 16 MOD 1 UBAs performed 63 dives: 20 each at 130 feet of sea water ( fsw ) for 30...minutes and 150 fsw for 35 minutes, and 23 at 300 fsw for 20 minutes (40, 45 and 91 msw). Decompression was according U.S. Navy Diving Manual...7 Oxygen Control Comparison with Legacy MK 16 MOD 1 ............................................ 7 Dives to 130 fsw

  18. Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

    PubMed Central

    Yap, Timothy A.; Yan, Li; Patnaik, Amita; Tunariu, Nina; Biondo, Andrea; Fearen, Ivy; Papadopoulos, Kyriakos P.; Olmos, David; Baird, Richard; Delgado, Liliana; Tetteh, Ernestina; Beckman, Robert A.; Lupinacci, Lisa; Riisnaes, Ruth; Decordova, Shaun; Heaton, Simon P.; Swales, Karen; deSouza, Nandita M; Leach, Martin O.; Garrett, Michelle D.; Sullivan, Daniel M.; de Bono, Johann S.; Tolcher, Anthony W.

    2014-01-01

    Purpose Multiple cancers harbor genetic aberrations that impact AKT signaling. MK-2206 is a potent pan-AKT inhibitor with a maximum tolerated dose (MTD) previously established at 60mg on alternate days (QOD). Due to a long half-life (60-80h), a weekly (QW) MK-2206 schedule was pursued to compare intermittent QW and continuous QOD dosing. Experimental Design Patients with advanced cancers were enrolled onto a QW dose-escalation phase I study to investigate the safety and pharmacokinetic-pharmacodynamic profiles of tumor and platelet-rich plasma (PRP). The QOD MTD of MK-2206 was also assessed in patients with ovarian and castration-resistant prostate cancers, and patients with advanced cancers undergoing multiparametric functional magnetic resonance imaging (MRI) studies, including dynamic contrast-enhanced MRI, diffusion-weighted imaging, magnetic resonance spectroscopy and intrinsic susceptibility-weighted MRI. Results Seventy-one patients were enrolled; 38 patients had 60mg MK-2206 QOD, while 33 received MK-2206 at 90mg, 135mg, 150mg, 200mg, 250mg, and 300mg QW. The QW MK-2206 MTD was established at 200mg following dose-limiting rash at 250mg and 300mg. QW dosing appeared to be similarly tolerated to QOD, with toxicities including rash, gastrointestinal symptoms, fatigue, and hyperglycemia. Significant AKT pathway blockade was observed with both continuous QOD and intermittent QW dosing of MK-2206 in serially-obtained tumor and PRP specimens. The functional imaging studies demonstrated that complex multiparametric MRI protocols may be effectively implemented in a phase I trial. Conclusions MK-2206 safely results in significant AKT pathway blockade in QOD and QW schedules. The intermittent dose of 200mg QW is currently used in phase II MK-2206 monotherapy and combination studies. PMID:25239610

  19. Jet shielding of jet noise

    NASA Technical Reports Server (NTRS)

    Simonich, J. C.; Amiet, R. K.; Schlinker, R. H.

    1986-01-01

    An experimental and theoretical study was conducted to develop a validated first principle analysis for predicting the jet noise reduction achieved by shielding one jet exhaust flow with a second, closely spaced, identical jet flow. A generalized fuel jet noise analytical model was formulated in which the acoustic radiation from a source jet propagates through the velocity and temperature discontinuity of the adjacent shielding jet. Input variables to the prediction procedure include jet Mach number, spacing, temperature, diameter, and source frequency. Refraction, diffraction, and reflection effects, which control the dual jet directivity pattern, are incorporated in the theory. The analysis calculates the difference in sound pressure level between the dual jet configuration and the radiation field based on superimposing two independent jet noise directivity patterns. Jet shielding was found experimentally to reduce noise levels in the common plane of the dual jet system relative to the noise generated by two independent jets.

  20. Measurement of the $W+$ jets differential cross-sections in $p\\bar{p}$ collisions at $\\sqrt{s} = 1.96$ TeV using the CDF II Detector

    SciTech Connect

    Driutti, Anna

    2016-01-01

    In this thesis the measurements of differential cross sections for the production of the $W$-boson in association with jets in $p\\bar{p}$ collisions at $\\sqrt{s} = 1.96$ TeV are presented. The measurements are based on 9.0 fb$^{-1}$ of CDF Run II data (i.e., the full dataset). Only events in which the W-boson decays leptonically (i.e., W → ev and W → μv)and at least one jet is present are considered. The lepton candidates are required to have a transverse energy $E^{\\ell}_T > 25$GeV and pseudorapidity in the range |n| < 1 whereas, the jets are reconstructed using the JETCLU algorithm with a radius of 0.4 requiring transverse energy $E^{jet}_T > 25$GeV and pseudorapidity in the range |ηjet| < 2. The reconstructed W-boson transverse mass should be greater than 40GeV/c2. The differential cross sections as a function of the jet multiplicity ($N$ > or = to 1, 2, 3, 4) and the leading jet transverse energy, are measured separately for each decay channel and then combined. For a meaningful comparison with theory the measured cross-sections are unfolded to remove detector effects. The resulting particle-level cross-sections are compared to theoretical predictions.

  1. Modifications of inhibitory transmission onto pyramidal neurons by postnatal exposure to MK-801: Effects of enriched environment.

    PubMed

    Shojaei, Amir; Anaraki, Afsaneh Kamali; Mirnajafi-Zadeh, Javad; Atapour, Nafiseh

    2017-04-01

    Early enriched environment (EE) prevents several deficits associated with postnatal MK-801 [N-Methyl-d-Aspartate (NMDA) receptor antagonist] treatment such as cognitive and locomotor deficits. We sought physiological correlates to such changes by looking at inhibitory synaptic inputs onto pyramidal cells in a prefrontal cortex slice preparation. Pharmacologically isolated γ-amino-butyric acid A (GABAA) receptor-mediated currents were measured using whole-cell patch clamp recordings. Wistar rats were raised in standard or EE from birth up to the time of experiments and were injected with saline or MK-801 (1mg/kg) on postnatal days (P) 6-10. We recorded miniature inhibitory post-synaptic currents (mIPSCs) of pyramidal cells in layer II/III of prefrontal cortex and measured their frequency, amplitude and kinetics. In control animals, the amplitude and frequency of mIPSCs increased strikingly during development from P21 to P28. MK-801 accelerated the development of mIPSCs frequency but caused a significant decrease in the amplitude of mIPSCs on P28 suggesting a significant reduction of inhibition onto pyramidal cells. EE per se led to a significant increase in both frequency and amplitude of mIPSCs, but its application to MK-801-treated rats resulted in moderate rescue of GABAergic transmission on P28. We conclude that postnatal MK-801 leads to reduced inhibitory transmission onto pyramidal cells of prefrontal cortex at adolescence which may underlie behavioural and morphological differences detected in vivo in rats. EE presentation from birth rather prevents GABAergic alterations associated with postnatal MK-801 treatment at adolescence.

  2. The impact of dynamic data assimilation on the numerical simulations of the QE II cyclone and an analysis of the jet streak influencing the precyclogenetic environment

    NASA Technical Reports Server (NTRS)

    Manobianco, John; Uccellini, Louis W.; Brill, Keith F.; Kuo, Ying-Hwa

    1992-01-01

    A mesoscale numerical model is combined with a dynamic data assimilation via Newtonian relaxation, or 'nudging', to provide initial conditions for subsequent simulations of the QE II cyclone. Both the nudging technique and the inclusion of supplementary data are shown to have a large positive impact on the simulation of the QE II cyclone during the initial phase of rapid cyclone development. Within the initial development period (from 1200 to 1800 UTC 9 September 1978), the dynamic assimilation of operational and bogus data yields a coherent two-layer divergence pattern that is not well defined in the model run using only the operational data and static initialization. Diagnostic analysis based on the simulations show that the initial development of the QE II storm between 0000 UTC 9 September and 0000 UTC 10 September was embedded within an indirect circulation of an intense 300-hPa jet streak, was related to baroclinic processes extending throughout a deep portion of the troposphere, and was associated with a classic two-layer mass-divergence profile expected for an extratropical cyclone.

  3. Multiple scattering of light in a spherical cometary atmosphere with an axisymmetric dust jet. II - Image simulation

    NASA Technical Reports Server (NTRS)

    Chick, Kenneth M.; Gombosi, Tamas I.

    1993-01-01

    A numerical solution for the multiple light scattering in spherical axisymmetric geometry is applied to the simulation of images of a coma as it would appear to a near-flying satellite such as Giotto. The appearance of symmetric comas and dust jets is examined in detail; the nucleus visibility is studied; the effect of forward scattering is considered; and single and multiple scattering effects are quantified. Attention is given to simulated images of a coma with a hollow cone of dust, as predicted by dust-gas hydrodynamic modeling. The cone's appearance is very similar to the northern area of activity on Comet Halley, observed by the Giotto HMC.

  4. DARK JETS IN SOLAR CORONAL HOLES

    SciTech Connect

    Young, Peter R.

    2015-03-10

    A new solar feature termed a dark jet is identified from observations of an extended solar coronal hole that was continuously monitored for over 44 hr by the Extreme Ultraviolet Imaging Spectrometer on board the Hinode spacecraft in 2011 February 8–10 as part of Hinode Operation Plan No. 177 (HOP 177). Line of sight (LOS) velocity maps derived from the coronal Fe xii λ195.12 emission line, formed at 1.5 MK, revealed a number of large-scale, jet-like structures that showed significant blueshifts. The structures had either weak or no intensity signal in 193 Å filter images from the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory, suggesting that the jets are essentially invisible to imaging instruments. The dark jets are rooted in bright points and occur both within the coronal hole and at the quiet Sun–coronal hole boundary. They exhibit a wide range of shapes, from narrow columns to fan-shaped structures, and sometimes multiple jets are seen close together. A detailed study of one dark jet showed LOS speeds increasing along the jet axis from 52 to 107 km s{sup −1} and a temperature of 1.2–1.3 MK. The low intensity of the jet was due either to a small filling factor of 2% or to a curtain-like morphology. From the HOP 177 sample, dark jets are as common as regular coronal hole jets, but their low intensity suggests a mass flux around two orders of magnitude lower.

  5. Rolipram attenuates MK-801-induced deficits in latent inhibition.

    PubMed

    Davis, Jennifer A; Gould, Thomas J

    2005-04-01

    Latent inhibition is used to examine attention and study cognitive deficits associated with schizophrenia. Research using MK-801, an N-methyl-D-aspartate (NMDA) open channel blocker, implicates glutamate receptors in acquisition of latent inhibition of cued fear conditioning. Evidence suggests an important relationship between NMDA-induced increases in cyclic adenosine monophosphate (cAMP) and learning and memory. The authors examine whether amplification of the cAMP signaling pathway by rolipram, a selective Type 4 cAMP phosphodiesterase inhibitor, reverses MK-801-induced impairments in latent inhibition. One day before training, mice were injected with MK-801, rolipram, MK-801 and rolipram, or vehicle and received 20 preexposures or no preexposures to an auditory conditioned stimulus (CS). Training consisted of 2 CS-footshock unconditioned stimulus pairings. Rolipram attenuated the disruptive effect of MK-801 on latent inhibition, which suggests a role for the cAMP signaling pathway in the task and implicates phosphodiesterase inhibition as a target for treating cognitive impairments associated with schizophrenia.

  6. The mystery of the frozen M-K medium.

    PubMed

    McGee, J; Lanier, J D

    1980-09-01

    Donor corneal material stored or transported in M-K medium can freeze easily if placed in an insulated environment, such as a styrofoam container, with ice that is colder than 0 degrees C. To assure proper maintenance of the recommended temperature of M-K medium of + 4 degrees C, the ice used should be allowed to stand at room temperature until it has a glistening, wet look to its surfaces. M-K medium already cooled to + 4 degrees C can be safely stored and maintained at + 4 degrees C in a well-insulated styrofoam container for approximately 24 hours if this type of glistening-wet, melting ice is used.

  7. Jetting tool

    SciTech Connect

    Szarka, D.D.; Schwegman, S.L.

    1991-07-09

    This patent describes an apparatus for hydraulically jetting a well tool disposed in a well, the well tool having a sliding member. It comprises positioner means for operably engaging the sliding member of the well tool; and a jetting means, connected at a rotatable connection to the positioner means so that the jetting means is rotatable relative to the positioner means and the well tool, for hydraulically jetting the well tool as the jetting means is rotated relative thereto.

  8. mkESA: enhanced suffix array construction tool.

    PubMed

    Homann, Robert; Fleer, David; Giegerich, Robert; Rehmsmeier, Marc

    2009-04-15

    We introduce the tool mkESA, an open source program for constructing enhanced suffix arrays (ESAs), striving for low memory consumption, yet high practical speed. mkESA is a user-friendly program written in portable C99, based on a parallelized version of the Deep-Shallow suffix array construction algorithm, which is known for its high speed and small memory usage. The tool handles large FASTA files with multiple sequences, and computes suffix arrays and various additional tables, such as the LCP table (longest common prefix) or the inverse suffix array, from given sequence data.

  9. Testing of 100 mK bolometers for space applications

    NASA Technical Reports Server (NTRS)

    Murray, A. G.; Ade, P. A. R.; Bhatia, R. S.; Griffin, M. J.; Maffei, B.; Nartallo, R.; Beeman, J. W.; Bock, J.; Lange, A.; DelCastillo, H.

    1996-01-01

    Electrical and optical performance data are presented for a prototype 100 mK spider-web bolometer operating under very low photon backgrounds. These data are compared with the bolometer theory and are used to estimate the expected sensitivity of such a detector used for low background space astronomy. The results demonstrate that the sensitivity and speed of response requirements of the bolometer instruments proposed for these missions can be met by 100 mK spider-web bolometers using neutron transmutation doped germanium as the temperature sensitive element.

  10. Analysis of Performance of Jet Engine from Characteristics of Components II : Interaction of Components as Determined from Engine Operation

    NASA Technical Reports Server (NTRS)

    Goldstein, Arthur W; Alpert, Sumner; Beede, William; Kovach, Karl

    1949-01-01

    In order to understand the operation and the interaction of jet-engine components during engine operation and to determine how component characteristics may be used to compute engine performance, a method to analyze and to estimate performance of such engines was devised and applied to the study of the characteristics of a research turbojet engine built for this investigation. An attempt was made to correlate turbine performance obtained from engine experiments with that obtained by the simpler procedure of separately calibrating the turbine with cold air as a driving fluid in order to investigate the applicability of component calibration. The system of analysis was also applied to prediction of the engine and component performance with assumed modifications of the burner and bearing characteristics, to prediction of component and engine operation during engine acceleration, and to estimates of the performance of the engine and the components when the exhaust gas was used to drive a power turbine.

  11. Sound generated by instability waves of supersonic flows. I Two-dimensional mixing layers. II - Axisymmetric jets

    NASA Technical Reports Server (NTRS)

    Tam, C. K. W.; Burton, D. E.

    1984-01-01

    An investigation is conducted of the phenomenon of sound generation by spatially growing instability waves in high-speed flows. It is pointed out that this process of noise generation is most effective when the flow is supersonic relative to the ambient speed of sound. The inner and outer asymptotic expansions corresponding to an excited instability wave in a two-dimensional mixing layer and its associated acoustic fields are constructed in terms of the inner and outer spatial variables. In matching the solutions, the intermediate matching principle of Van Dyke and Cole is followed. The validity of the theory is tested by applying it to an axisymmetric supersonic jet and comparing the calculated results with experimental measurements. Very favorable agreements are found both in the calculated instability-wave amplitude distribution (the inner solution) and the near pressure field level contours (the outer solution) in each case.

  12. Use of a Ni60Ti shape memory alloy for active jet engine chevron application: II. Experimentally validated numerical analysis

    NASA Astrophysics Data System (ADS)

    Hartl, D. J.; Mooney, J. T.; Lagoudas, D. C.; Calkins, F. T.; Mabe, J. H.

    2010-01-01

    A shape memory alloy (SMA) composition of Ni60Ti40 (wt%) was chosen for the fabrication of active beam components used as cyclic actuators and incorporated into morphing aerospace structures. The active structure is a variable-geometry chevron (VGC) designed to reduce jet engine noise in the take-off flight regime while maintaining efficiency in the cruise regime. This two-part work addresses the training, characterization and derived material properties of the new nickel-rich NiTi composition, the assessment of the actuation properties of the active beam actuator and the accurate analysis of the VGC and its subcomponents using a model calibrated from the material characterization. The second part of this two-part work focuses on the numerical modeling of the jet engine chevron application, where the end goal is the accurate prediction of the VGC actuation response. A three-dimensional (3D) thermomechanical constitutive model is used for the analysis and is calibrated using the axial testing results from part I. To best capture the material response, features of several SMA constitutive models proposed in the literature are combined to form a new model that accounts for two material behaviors not previously addressed simultaneously. These are the variation in the generated maximum actuation strain with applied stress level and a smooth strain-temperature constitutive response at the beginning and end of transformation. The accuracy of the modeling effort is assessed by comparing the analysis deflection predictions for a given loading path imposed on the VGC or its subcomponents to independently obtained experimental results consisting of photogrammetric data. For the case of full actuation of the assembled VGC, the average error in predicted centerline deflection is less than 6%.

  13. 300 mK and 50 mK cooling systems for long-life space applications

    NASA Astrophysics Data System (ADS)

    Reed, J.; Perkinson, M. C.; D'Arrigo, P.; Geelen, K.; Hepburn, I.; Brockley-Blatt, C.; Duband, L.; Bradshaw, T.

    2008-05-01

    The X-ray Evolving Universe Spectroscopy mission is a candidate for the ESA Cosmic Vision 2015-2025 plan, with two possible instruments at 300 mK and 50 mK. Astrium, under ESA contract, has worked with MSSL, RAL, and CEA-SBT, to propose a suitable payload accommodation scheme meeting ESA's requirements. Exhaustive trade-offs were performed, according to a described methodology, leading to two designs incorporating closed-cycle active coolers maximizing well proven heritage concepts. These concepts are described, and although they have been prepared for XEUS, there are other future mission concepts which could also benefit from 50 mK cooling with a lifetime greater than 10 years.

  14. Fuzzy jets

    SciTech Connect

    Mackey, Lester; Nachman, Benjamin; Schwartzman, Ariel; Stansbury, Conrad

    2016-06-01

    Collimated streams of particles produced in high energy physics experiments are organized using clustering algorithms to form jets . To construct jets, the experimental collaborations based at the Large Hadron Collider (LHC) primarily use agglomerative hierarchical clustering schemes known as sequential recombination. We propose a new class of algorithms for clustering jets that use infrared and collinear safe mixture models. These new algorithms, known as fuzzy jets , are clustered using maximum likelihood techniques and can dynamically determine various properties of jets like their size. We show that the fuzzy jet size adds additional information to conventional jet tagging variables in boosted topologies. Furthermore, we study the impact of pileup and show that with some slight modifications to the algorithm, fuzzy jets can be stable up to high pileup interaction multiplicities.

  15. Fuzzy jets

    DOE PAGES

    Mackey, Lester; Nachman, Benjamin; Schwartzman, Ariel; ...

    2016-06-01

    Collimated streams of particles produced in high energy physics experiments are organized using clustering algorithms to form jets . To construct jets, the experimental collaborations based at the Large Hadron Collider (LHC) primarily use agglomerative hierarchical clustering schemes known as sequential recombination. We propose a new class of algorithms for clustering jets that use infrared and collinear safe mixture models. These new algorithms, known as fuzzy jets , are clustered using maximum likelihood techniques and can dynamically determine various properties of jets like their size. We show that the fuzzy jet size adds additional information to conventional jet tagging variablesmore » in boosted topologies. Furthermore, we study the impact of pileup and show that with some slight modifications to the algorithm, fuzzy jets can be stable up to high pileup interaction multiplicities.« less

  16. Search for vector-like quark production in the lepton+jets and dilepton+jets final states using 5.4 fb-1 of Run II data

    SciTech Connect

    Caughron, Seth

    2011-01-01

    The Standard Model of particle physics provides an excellent description of particle interactions at energies up to ~1 TeV, but it is expected to fail above that scale. Multiple models developed to describe phenomena above the TeV scale predict the existence of very massive, vector-like quarks. A search for single electroweak production of such particles in p$\\bar{p}$ collisions at a center-of-mass energy of 1.96 TeV is performed in the W+jets and Z+jets channels. The data were collected by the DØ detector at the Fermilab Tevatron Collider and correspond to an integrated luminosity of 5.4 fb-1. Events consistent with a heavy object decaying to a vector boson and a jet are selected. We observe no significant excess in comparison to the background prediction and set 95% confidence level upper limits on production cross sections for vector-like quarks decaying to W+jet and Z+jet. Assuming a vector-like quark -- standard model quark coupling parameter $\\tilde{κ}$qQ of unity, we exclude vector-like quarks with mass below 693 GeV for decays to W+jet and mass below 449 GeV for decays to Z+jet. These represent the most sensitive limits to date.

  17. Inclusive jet production at the Tevatron

    SciTech Connect

    Norniella, Olga; /Barcelona, IFAE

    2006-08-01

    Preliminary results on inclusive jet production in proton-antiproton collisions at {radical}s = 1.96 TeV based on 1 fb{sup -1} of CDF Run II data are presented. Measurements are preformed using different jet algorithms in a wide range of jet transverse momentum and jet rapidity. The measured cross sections are compared to next-to-leading order perturbative QCD calculations

  18. Explosive Nucleosynthesis in Magnetohydrodynamical Jets from Collapsars. II --- Heavy-Element Nucleosynthesis of s, p, r-Processes

    NASA Astrophysics Data System (ADS)

    Ono, M.; Hashimoto, M.; Fujimoto, S.; Kotake, K.; Yamada, S.

    2012-10-01

    We investigate the nucleosynthesis in a massive star of 70 M_{⊙} with solar metallicity in the main sequence stage. The helium core mass after hydrogen burning corresponds to 32 M_{⊙}. Nucleosynthesis calculations have been performed during the stellar evolution and the jetlike supernova explosion of a collapsar model. We focus on the production of elements heavier than iron group nuclei. Nucleosynthesis calculations have been accomplished consistently from hydrostatic to dynamic stages by using large nuclear reaction networks, where the weak s-, p-, and r-processes are taken into account. We confirm that s-elements of 60 < A < 90 are highly overproduced relative to the solar abundances in the hydrostatic nucleosynthesis. During oxygen burning, p-elements of A > 90 are produced via photodisintegrations of seed s-elements. However, the produced p-elements are disintegrated in later stages except for ^{180}Ta. In the explosive nucleosynthesis, elements of 90 < A < 160 are significantly overproduced relative to the solar values owing to the r-process, which is very different from the results of spherical explosion models. Only heavy p-elements (N > 50) are overproduced via the p-process because of the low peak temperatures in the oxygen- and neon-rich layers. Compared with the previous study of r-process nucleosynthesis calculations in the collapsar model of 40 M_{⊙} by Fujimoto et al. [S. Fujimoto, M. Hashimoto, K. Kotake and S. Yamada, Astrophys. J. 656 (2007), 382; S. Fujimoto, N. Nishimura and M. Hashimoto, Astrophys. J. 680 (2008), 1350], our jet model cannot contribute to the third peak of the solar r-elements and intermediate p-elements, which have been much produced because of the distribution of the lowest part of electron fraction in the ejecta. Averaging the overproduction factors over the progenitor masses with the use of Salpeter's IMF, we suggest that the 70 M_{⊙} star could contribute to the solar weak s}-elements of 60 < A < 90 and neutron

  19. A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.

    PubMed Central

    Kitamura, M.; Shirasawa, T.; Mitarai, T.; Muramatsu, T.; Maruyama, N.

    1993-01-01

    The aim of this study was to survey the expression of an embryonic cytokine gene, MK, in the normal organs and neoplastic tissues of adults. Northern analysis showed that MK mRNA was exclusively expressed in the kidney among murine organs including thymus, lung, heart, spleen, liver, and kidney. In situ hybridization analysis revealed that MK expression was localized in the proximal tubules and metaplastic Bowman's epithelium, but not in other nephron segments such as glomeruli, loop of Henle, distal tubules, and collecting ducts. To investigate whether MK expression is a marker of tubular cell lineage, several cell lines originating from renal tubules were tested. No expression of MK was detected in PtK1 and LLC-PK1 cells derived from marsupial and porcine proximal tubules or in MDBK and MDCK cells from bovine and canine distal/collecting tubules. Unexpectedly, the MK gene was expressed in a human renal cell carcinoma line, VMRC-RCW, and the expression was up-regulated in the presence of retinoic acid. To elucidate the involvement of MK in the development of tumors, we further examined its expression in a variety of human neoplastic cell lines: YMB-1-C (breast cancer), EBC-1 (lung squamous cell carcinoma), RERF-LC-OK (lung adenocarcinoma), SBC-3 (lung small cell carcinoma), HSC-2 (mouth squamous cell carcinoma), NUGC-2 (gastric cancer), COLO201 (colon cancer), HepG2 (hepatoma), MIA PaCa-2 (pancreatic cancer), MCAS (ovarian cancer), HeLa (cervical cancer), BeWo (chorionic carcinoma), ITO-II (testicular tumor), T24 (urinary bladder tumor), and G-401 (Wilms' tumor). Strong signals were detected in COLO201, HepG2, ITO-II, T24, G-401, and weaker but distinct signals were detected in YMB-1-C, HSC-2, and MCAS cells. The MK gene was, therefore, widely expressed in neoplastic cells originating from genital organs, intestinal tract, liver, mammary gland, and urinary tract, and the expression was not restricted to adenocarcinomas, but was also observed in other types of

  20. Replacement of SR 4990 by Barium Styphnate in the Mk 24 Actuator

    DTIC Science & Technology

    the SR-4990 in the Mk 24 Actuator. Experimental work was performed with barium styphnate , lead mononitroresorcinate, and two manufactured powders...Candidate materials were first screened using a pressure bomb. Final testing was performed in the Mk 24 Actuator design. Test results showed that of the four candidates, barium styphnate is the best material for the Actuator Mk 24.

  1. MK-801 protects against neuronal injury induced by electrical stimulation.

    PubMed

    Agnew, W F; McCreery, D B; Yuen, T G; Bullara, L A

    1993-01-01

    The ability of MK-801, a non-competitive N-methyl-D-aspartate receptor antagonist, to protect neurons in the cerebral cortex from injury induced by prolonged electrical stimulation was assessed in cats. Platinum disc electrodes 8.0 mm in diameter and with a surface area of 0.5 cm2 were implanted in the subdural space over the parietal cortex. Ten days after implantation of the electrodes, all animals received continuous stimulation for 7 h using charge-balanced, cathodic-first, controlled current pulses with a charge density of 20 microC/cm2 and a charge/phase of 10 microC/phase. They received either no MK-801, or 0.33 or 5.0 mg/kg (i.v.) administered intravenously, just before the start of the stimulation. Immediately following the stimulation, the animals were perfused and the cerebral cortex examined by light microscopy at eight sites beneath the electrodes. Neuronal damage in the form of shrunken, hyperchromic neurons and perineuronal halos was present only beneath the stimulating electrodes; damage was moderate to severe in stimulated animals that had not received MK-801, slight in animals receiving 0.33 mg/kg, and none to slight in animals receiving 5.0 mg/kg. These results indicate that MK-801, in an apparently dose-dependent fashion, provides substantial but not complete protection against neuronal injury induced by prolonged electrical stimulation. Thus prolonged electrical stimulation can be added to the list of neuropathologic conditions which involve glutamate-induced excitotoxic damage via the N-methyl-D-aspartate receptor. The results also support the hypothesis of neuronal hyperactivity as a principal cause of electrically-induced injury in the central nervous system. The implications for design of protocols for functional electrical stimulation are discussed.

  2. 300 mK Continuous Cooling, Sorption-Adr System

    NASA Astrophysics Data System (ADS)

    Duval, J. M.; Duband, L.; Luchier, N.; Tirolien, T.

    2010-04-01

    The 300 mK cooling system of two instruments onboard the Herschel satellite is achieved by the use of 3He sorption coolers developed and manufactured in CEA/SBT. This cooling system provides alternate (i.e. one-shot) cooling. The addition of a small ADR stage with a gas-gap heat switch allows continuous cooling at 300 mK by using the magnetic stage as an active thermal ballast. The realization of this continuous cooling based on a Herschel type sorption cooler is described here. It is shown that our prototype can provide continuous cooling at a stable temperature or alternatively gives the possibility of changing the setting of the nominal temperature rapidly and without thermal losses. The former mode is indeed extremely useful for detector tests and qualifications. The thermal stability is discussed. This project funded by the French Space Agency, CNES, will also provide additional knowledge to CEA/SBT in the design and realization of 50 mK cooling system using these coupled technologies.

  3. Parallel Calculation of CCSDT and Mk-MRCCSDT Energies.

    PubMed

    Prochnow, Eric; Harding, Michael E; Gauss, Jürgen

    2010-08-10

    A scheme for the parallel calculation of energies at the coupled-cluster singles, doubles, and triples (CCSDT) level of theory, several approximate iterative CCSDT schemes (CCSDT-1a, CCSDT-1b, CCSDT-2, CCSDT-3, and CC3), and for the state-specific multireference coupled-cluster ansatz suggested by Mukherjee with a full treatment of triple excitations (Mk-MRCCSDT) is presented. The proposed scheme is based on the adaptation of a highly efficient serial coupled-cluster code leading to a communication-minimized implementation by parallelizing the time-determining steps. The parallel algorithm is tailored for affordable cluster architectures connected by standard communication networks such as Gigabit Ethernet. In this way, CCSDT and Mk-MRCCSDT computations become feasible even for larger molecular systems and basis sets. An analysis of the time-determining steps for CCSDT and Mk-MRCCSDT, namely the computation of the triple-excitation amplitudes and their individual contributions, is carried out. Benchmark calculations are presented for the N2O, ozone, and benzene molecules, proving that the parallelization of these steps is sufficient to obtain an efficient parallel scheme. A first application to the case of 2,6-pyridyne using a triple-ζ quality basis (222 basis functions) is presented demonstrating the efficiency of the current implementation.

  4. MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points

    PubMed Central

    Dahlmans, Vivian E. H.; Spaapen, Frank; Salvaing, Juliette; Vanhove, Jolien; Geijselaers, Claudia; Bartels, Stefanie J. J.; Partouns, Iris; Neumann, Dietbert; Speel, Ernst-Jan; Takihara, Yoshihiro; Wouters, Bradly G.; Voncken, Jan Willem

    2015-01-01

    Although the MK3 gene was originally found deleted in some cancers, it is highly expressed in others. The relevance of MK3 for oncogenesis is currently not clear. We recently reported that MK3 controls ERK activity via a negative feedback mechanism. This prompted us to investigate a potential role for MK3 in cell proliferation. We here show that overexpression of MK3 induces a proliferative arrest in normal diploid human fibroblasts, characterized by enhanced expression of replication stress- and senescence-associated markers. Surprisingly, MK3 depletion evokes similar senescence characteristics in the fibroblast model. We previously identified MK3 as a binding partner of Polycomb Repressive Complex 1 (PRC1) proteins. In the current study we show that MK3 overexpression results in reduced cellular EZH2 levels and concomitant loss of epigenetic H3K27me3-marking and PRC1/chromatin-occupation at the CDKN2A/INK4A locus. In agreement with this, the PRC1 oncoprotein BMI1, but not the PCR2 protein EZH2, bypasses MK3-induced senescence in fibroblasts and suppresses P16INK4A expression. In contrast, BMI1 does not rescue the MK3 loss-of-function phenotype, suggesting the involvement of multiple different checkpoints in gain and loss of MK3 function. Notably, MK3 ablation enhances proliferation in two different cancer cells. Finally, the fibroblast model was used to evaluate the effect of potential tumorigenic MK3 driver-mutations on cell proliferation and M/SAPK signaling imbalance. Taken together, our findings support a role for MK3 in control of proliferation and replicative life-span, in part through concerted action with BMI1, and suggest that the effect of MK3 modulation or mutation on M/SAPK signaling and, ultimately, proliferation, is cell context-dependent. PMID:25853770

  5. Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.

    PubMed

    Wolkenberg, Scott E; Nolt, M Brad; Bilodeau, Mark T; Trotter, B Wesley; Manley, Peter J; Kett, Nathan R; Nanda, Kausik K; Wu, Zhicai; Cato, Matthew J; Kane, Stefanie A; Kiss, Laszlo; Spencer, Robert H; Wang, Jixin; Lynch, Joseph J; Regan, Christopher P; Stump, Gary L; Li, Bing; White, Rebecca; Yeh, Suzie; Dinsmore, Christopher J; Lindsley, Craig W; Hartman, George D

    2017-02-15

    Selective inhibition of Kv1.5, which underlies the ultra-rapid delayed rectifier current, IKur, has been pursued as a treatment for atrial fibrillation. Here we describe the discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity versus the off-target current IKs, whose inhibition has been associated with ventricular proarrhythmia. MK-1832 exhibits improved selectivity for IKur over IKs (>3000-fold versus 70-fold for MK-0448), consistent with an observed larger window between atrial and ventricular effects in vivo (>1800-fold versus 210-fold for MK-0448). MK-1832 also exhibits an improved preclinical pharmacokinetic profile consistent with projected once daily dosing in humans.

  6. Search for Third Generation Squarks in the Missing Transverse Energy plus Jet Sample at CDF Run II

    SciTech Connect

    Marono, Miguel Vidal

    2010-03-01

    lightest SUSY particle (LSP) which would provide a candidate for cold dark matter, that account for 23% of the universe content, as strongly suggested by recent astrophysical data [1]. The Tevatron is a hadron collider operating at Fermilab, USA. This accelerator provides proton-antiproton (p$\\bar{p}$) collisions with a center of mass energy of √s = 1.96 TeV. CDF and D0 are the detectors built to analyse the products of the collisions provided by the Tevatron. Both experiments have produced a very significant scientific output in the last few years, like the discovery of the top quark or the measurement of the Bs mixing. The Tevatron experiments are also reaching sensitivity to the SM Higgs boson. The scientific program of CDF includes a broad spectrum on searches for physics signatures beyond the Standard Model. Tevatron is still the energy frontier, what means an unique opportunity to produce a discovery in physic beyond the Standard Model. The analyses presented in this thesis focus on the search for third generation squarks in the missing transverse energy plus jets final state. The production of sbottom ($\\tilde{b}$) and stop ($\\tilde{t}$) quarks could be highly enhanced at the Tevatron, giving the possibility of discovering new physics or limiting the parameter space available in the theory. No signal is found over the predicted Standard Model background in both searches. Instead, 95% confidence level limits are set on the production cross section, and then translated into the mass plane of the hypothetical particles. This thesis sketches the basic theory concepts of the Standard Model and the Minimal Supersymmetric Extension in Chapter 2. Chapter 3, describes the Tevatron and CDF. Based on the CDF subsystems information, Chapter 4 and 5 describe the analysis objet reconstruction and the heavy flavor tagging tools. The development of the analyses is shown in Chapter 6 and Chapter 7. Finally, Chapter 8 is devoted to discuss the results and conclusions

  7. Jet maximization, axis minimization, and stable cone finding

    NASA Astrophysics Data System (ADS)

    Thaler, Jesse

    2015-10-01

    Jet finding is a type of optimization problem, where hadrons from a high-energy collision event are grouped into jets based on a clustering criterion. As three interesting examples, one can form a jet cluster that (i) optimizes the overall jet four-vector, (ii) optimizes the jet axis, or (iii) aligns the jet axis with the jet four-vector. In this paper, we show that these three approaches to jet finding, despite being philosophically quite different, can be regarded as descendants of a mother optimization problem. For the special case of finding a single cone jet of fixed opening angle, the three approaches are genuinely identical when defined appropriately, and the result is a stable cone jet with the largest value of a quantity J . This relationship is only approximate for cone jets in the rapidity-azimuth plane, as used at the Large Hadron Collider, though the differences are mild for small radius jets.

  8. Water Jetting

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Hi-Tech Inc., a company which manufactures water jetting equipment, needed a high pressure rotating swivel, but found that available hardware for the system was unsatisfactory. They were assisted by Marshall, which had developed water jetting technology to clean the Space Shuttles. The result was a completely automatic water jetting system which cuts rock and granite and removes concrete. Labor costs have been reduced; dust is suppressed and production has been increased.

  9. Cosmic jets

    NASA Technical Reports Server (NTRS)

    Rees, M. J.

    1986-01-01

    The evidence that active galactic nuclei produce collimated plasma jets is summarised. The strongest radio galaxies are probably energised by relativistic plasma jets generated by spinning black holes interacting with magnetic fields attached to infalling matter. Such objects can produce e(+)-e(-) plasma, and may be relevant to the acceleration of the highest-energy cosmic ray primaries. Small-scale counterparts of the jet phenomenon within our own galaxy are briefly reviewed.

  10. Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

    PubMed Central

    Maruyama, Junichi; Kobayashi, Yumie; Umeda, Tsuyoshi; Vandewalle, Alain; Takeda, Kohsuke; Ichijo, Hidenori; Naguro, Isao

    2016-01-01

    The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling pathway for triggering pseudohypoaldosteronism type II (PHAII), an autosomal dominant hereditary disease that is characterized by hypertension. However, the molecular mechanism(s) by which the WNK-SPAK/OSR1 pathway is regulated remain unclear. In this report, we identified WNK4 as an interacting partner of a recently identified MAP3K, apoptosis signal-regulating kinase 3 (ASK3). We found that WNK4 is phosphorylated in an ASK3 kinase activity-dependent manner. By exploring the ASK3-dependent phosphorylation sites, we identified Ser575 as a novel phosphorylation site in WNK4 by LC-MS/MS analysis. ASK3-dependent WNK4 Ser575 phosphorylation was mediated by the p38MAPK-MAPK-activated protein kinase (MK) pathway. Osmotic stress, as well as hypotonic low-chloride stimulation, increased WNK4 Ser575 phosphorylation via the p38MAPK-MK pathway. ASK3 was required for the p38MAPK activation induced by hypotonic stimulation but was not required for that induced by hypertonic stimulation or hypotonic low-chloride stimulation. Our results suggest that the p38MAPK-MK pathway might regulate WNK4 in an osmotic stress-dependent manner but its upstream regulators might be divergent depending on the types of osmotic stimuli. PMID:26732173

  11. Measurement of σ(p$\\bar{p}$ -> t$\\bar{t}$) in the τ + jets channel by the D0 experiment at Run II of the Tevatron Collider

    SciTech Connect

    Arov, Mikhail

    2008-07-01

    The top quark is the heaviest and most mysterious of the known elementary particles. Therefore, careful study of its production rate and other properties is of utmost importance for modern particle physics. The Tevatron is the only facility currently capable of studying top quark properties by on-shell production. Measurement of the top quark pair production cross section is one of the major goals of the Tevatron Run II physics program. It provides an excellent test of QCD at energies exceeding 100 GeV. We report on a new measurement of p$\\bar{p}$ → t$\\bar{t}$ production at √s = 1.96 TeV using 350 pb-1 of data collected with the D0 detector between 2002 and 2005. We focus on the final state where a W boson from one of the top quarks decays into a τ lepton and its associated neutrino, while the other decays into a quark-antiquark pair. We aim to select those events in which the τ lepton subsequently decays to one or three charged hadrons, zero or more neutral hadrons and a tau neutrino (the charge conjugate processes are implied in all of the above). The observable signature thus consists of a narrow calorimeter shower with associated track(s) characteristic of a hadronic tau decay, four or more jets, of which two are initiated by b quarks accompanying the W's in the top quark decays, and a large net missing momentum in the transverse plane due to the energetic neutrino-antineutrino pair that leave no trace in the detector media. The preliminary result for the measured cross section is: σ(t$\\bar{t}$) = 5.1$+4.3\\atop{-3.5}$(stat) $+0.7\\atop{-0.7}$(syst) ± 0.3 (lumi.) pb.

  12. Intermittent maser flare around the high-mass young stellar object G353.273 + 0.641 - II. Detection of a radio and molecular jet

    NASA Astrophysics Data System (ADS)

    Motogi, K.; Sorai, K.; Niinuma, K.; Sugiyama, K.; Honma, M.; Fujisawa, K.

    2013-01-01

    We report the first detection of a radio continuum and molecular jet associated with a dominant blue-shifted maser source, G353.273+0.641. A radio jet is extended 3000 au along the north-west-south-east (NW-SE) direction. H2O masers are found to be clustered in the root of a bipolar radio jet. A molecular jet is detected by thermal SiO ( \\upsilon = 0, J = 2-1) emission. The SiO spectrum is extremely wide ( - 120 to +87 km s- 1) and significantly blue-shift dominated, similar to the maser emission. The observed geometry and remarkable spectral similarity between H2O maser and SiO strongly suggest the existence of a maser-scale ( ˜ 340 au) molecular jet that is enclosed by the extended radio jet. We propose a disc-masking scenario as the origin of the strong blue-shift dominance, where an optically thick disc obscures a red-shifted lobe of a compact jet.

  13. Isolation of the Entomopathogenic Fungal Strain Cod-MK1201 from a Cicada Nymph and Assessment of Its Antibacterial Activities.

    PubMed

    Sangdee, Kusavadee; Nakbanpote, Woranan; Sangdee, Aphidech

    2015-01-01

    The entomopathogenic fungus Cod-MK1201 was isolated from a dead cicada nymph. Three regions of ribosomal nuclear DNA, the internal transcribed spacers of nuclear ribosomal DNA repeats (ITS), the partial small subunit of rDNA (nrSSU) , and the partial large subunit of rDNA (nrLSU), and two protein-coding regions, the elongation factor 1α (EF-1α), and the largest subunit of the RNA polymerase II (rpb1) gene, were sequenced and used for fungal identification. The phylogenetic analysis of the ITS and the combined data set of the five genes indicated that the fungal isolate Cod-MK1201 is a new strain of Cordyceps sp. that is closely related to Cordyceps nipponica and C. kanzashiana. Crude extracts of mycelium-cultured Cod-MK1201 were obtained using distilled water and 50% (v/v) ethanol, and the antibacterial activity of each was determined. Both extracts had activity against Gram-positive and Gram-negative bacteria, but the ethanol extract was the more potent of the two. The antibacterial activity of the protein fractions of these extracts was also determined. The protein fraction from the ethanol extract was more antibacterial than the protein fraction from the aqueous extract. Three antibacterial constituents including adenosine, the total phenolic content (TPC), and the total flavonoid content (TFC) was also determined. The results showed that the adenosine content, the TPC, and the TFC of the ethanol extract were more active than those of the aqueous extract. Moreover, synergism was detected between these antibacterial constituents. In conclusion, the entomopathogenic fungal isolate Cod-MK1201 represents a natural source of antibacterial agents.

  14. Equilibrium shape of (4)He crystal under zero gravity below 200 mK.

    PubMed

    Takahashi, Takuya; Ohuchi, Haruka; Nomura, Ryuji; Okuda, Yuichi

    2015-10-01

    Equilibrium crystal shape is the lowest energy crystal shape that is hardly realized in ordinary crystals because of their slow relaxation. (4)He quantum crystals in a superfluid have been expected as unique exceptions that grow extremely fast at very low temperatures. However, on the ground, gravity considerably deforms the crystals and conceals the equilibrium crystal shape, and thus, gravity-free environment is needed to observe the equilibrium shape of (4)He. We report the relaxation processes of macroscopic (4)He crystals in a superfluid below 200 mK under zero gravity using a parabolic flight of a jet plane. When gravity was removed from a gravity-flattened (4)He crystal, the crystal rapidly transformed into a shape with flat surfaces. Although the relaxation processes were highly dependent on the initial condition, the crystals relaxed to a nearly homothetic shape in the end, indicating that they were truly in an equilibrium shape minimizing the interfacial free energy. Thanks to the equilibrium shape, we were able to determine the Wulff's origin and the size of the c-facet together with the vicinal surface profile next to the c-facet. The c-facet size was extremely small in the quantum crystals, and the facet-like flat surfaces were found to be the vicinal surfaces. At the same time, the interfacial free energy of the a-facet and s-facet was also obtained.

  15. MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris.

    PubMed

    Mao, Xuming; Li, Hong; Sano, Yasuyo; Gaestel, Matthias; Mo Park, Jin; Payne, Aimee S

    2014-01-01

    Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by autoantibodies to the keratinocyte adhesion protein desmoglein 3 (Dsg3). Previous studies suggest that PV pathogenesis involves p38 mitogen-activated protein kinase-dependent and -independent pathways. However, p38 is a difficult protein to study and therapeutically target because it has four isoforms and multiple downstream effectors. In this study, we identify MAPKAP (mitogen-activated protein kinase-activated protein) kinase 2 (MK2) as a downstream effector of p38 signaling in PV and describe MK2-dependent and -independent mechanisms of blister formation using passive transfer of human anti-Dsg IgG4 mAbs to neonatal mice. In human keratinocytes, PV mAbs activate MK2 in a dose-dependent manner. MK2 is also activated in human pemphigus skin blisters, causing translocation of MK2 from the nucleus to the cytosol. Small-molecule inhibition of MK2 and silencing of MK2 expression block PV mAb-induced Dsg3 endocytosis in human keratinocytes. In addition, small-molecule inhibition and genetic deletion of p38α and MK2 inhibit spontaneous but not induced suprabasal blisters by PV mAbs in mouse passive transfer models. Collectively, these data suggest that MK2 is a key downstream effector of p38 that can modulate PV autoantibody pathogenicity. MK2 inhibition may be a valuable adjunctive therapy for control of pemphigus blistering.

  16. The evolution of instabilities in the axisymmetric jet. I - The linear growth of disturbances near the nozzle. II - The flow resulting from the interaction between two waves

    NASA Technical Reports Server (NTRS)

    Cohen, J.; Wygnanski, I.

    1987-01-01

    The modal distribution of coherent structures evolving near the nozzle of a circular jet was studied experimentally and theoretically, with particular attention given to the effects produced on the instability modes by transverse curvature, flow divergence, inhomogeneous inflow conditions, and the detailed shape of the mean velocity profile. Experiments were performed using a specially constructed air-jet facility; hot-wire anemometers were used in conjunction with Disa Model 55P11 sensors for flow measurements. The linear model used as a transfer function is capable of predicting the spectral distribution of the velocity perturbations in a jet. Consideration was also given to studies of leading nonlinear interactions generated by waves externally superimposed on an axisymmetric jet; theoretical predictions were verified experimentally.

  17. Bouncing Jets

    NASA Astrophysics Data System (ADS)

    Wadhwa, Navish; Vlachos, Pavlos; Jung, Sunghwan

    2011-11-01

    Contrary to common intuition, free jets of fluid can ``bounce'' off each other on collision in mid-air, through the effect of a lubricating air film that separates the jets. We have developed a simple experimental setup to stably demonstrate and study the non-coalescence of jets on collision. We present the results of an experimental investigation of oblique collision between two silicone oil jets, supported by a simple analytical explanation. Our focus is on elucidating the role of various physical forces at play such as viscous stresses, capillary force and inertia. A parametric study conducted by varying the nozzle diameter, jet velocity, angle of inclination and fluid viscosity reveals the scaling laws for the quantities involved such as contact time. We observed a transition from bouncing to coalescence with an increase in jet velocity and inclination angle. We propose that a balance between the contact time of jets and the time required for drainage of the trapped air film can provide a criterion for transition from non-coalescence to coalescence.

  18. Experiment on performance of adjustable jet pump

    NASA Astrophysics Data System (ADS)

    Zhu, J. M.; Long, X. P.; Zhang, S. B.; Lu, X.

    2012-11-01

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  19. 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

    SciTech Connect

    Argiriadi, Maria A.; Ericsson, Anna M.; Harris, Christopher M.; Banach, David L.; Borhani, David W.; Calderwood, David J.; Demers, Megan D.; DiMauro, Jennifer; Dixon, Richard W.; Hardman, Jennifer; Kwak, Silvia; Li, Biqin; Mankovich, John A.; Marcotte, Douglas; Mullen, Kelly D.; Ni, Baofu; Pietras, M.; Sadhukhan, Ramkrishna; Sousa, Silvino; Tomlinson, Medha J.; Wang, L.; Xiang, T.; Talanian, R.V.

    2010-09-17

    MK2 is a Ser/Thr kinase of significant interest as an anti-inflammatory drug discovery target. Here we describe the development of in vitro tools for the identification and characterization of MK2 inhibitors, including validation of inhibitor interactions with the crystallography construct and determination of the unique binding mode of 2,4-diaminopyrimidine inhibitors in the MK2 active site.

  20. MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells

    PubMed Central

    Bridges, Kathleen A.; Chen, Xingxing; Liu, Huifeng; Rock, Crosby; Buchholz, Thomas A.; Shumway, Stuart D.; Skinner, Heath D.; Meyn, Raymond E.

    2016-01-01

    Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase inhibitor, MK-8776, for its ability to radiosensitize human tumor cells. Cells derived from NSCLC and HNSCC cancers were tested for radiosensitization by MK-8776. The ability of MK-8776 to abrogate the radiation-induced G2 block was determined using flow cytometry. Effects on repair of radiation-induced DNA double strand breaks (DSBs) were determined on the basis of rad51, γ-H2AX and 53BP1 foci. Clonogenic survival analyses indicated that MK-8776 radiosensitized p53-defective tumor cells but not lines with wild-type p53. Abrogation of the G2 block was evident in both p53-defective cells and p53 wild-type lines indicating no correlation with radiosensitization. However, only p53-defective cells entered mitosis harboring unrepaired DSBs. MK-8776 appeared to inhibit repair of radiation-induced DSBs at early times after irradiation. A comparison of MK-8776 to the wee1 inhibitor, MK-1775, suggested both similarities and differences in their activities. In conclusion, MK-8776 radiosensitizes tumor cells by mechanisms that include abrogation of the G2 block and inhibition of DSB repair. Our findings support the clinical evaluation of MK-8776 in combination with radiation. PMID:27690219

  1. The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths in PC12 Cells

    PubMed Central

    Flowers, Brittany M.; Rusnak, Lauren E.; Wong, Kristen E.; Banks, Dallas A.; Munyikwa, Michelle R.; McFarland, Alexander G.; Hinton, Shantá D.

    2014-01-01

    The rat pheochromocytoma PC12 cell line is a widely used system to study neuronal differentiation for which sustained activation of the extracellular signaling related kinase (ERK) pathway is required. Here, we investigate the function of MK-STYX [MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein] in neuronal differentiation. MK-STYX is a member of the MAPK phosphatase (MKP) family, which is generally responsible for dephosphorylating the ERKs. However, MK-STYX lacks catalytic activity due to the absence of the nucleophilic cysteine in the active site signature motif HC(X5)R that is essential for phosphatase activity. Despite being catalytically inactive, MK-STYX has been shown to play a role in important cellular pathways, including stress responses. Here we show that PC12 cells endogenously express MK-STYX. In addition, MK-STYX, but not its catalytically active mutant, induced neurite-like outgrowths in PC12 cells. Furthermore, MK-STYX dramatically increased the number of cells with neurite extensions in response to nerve growth factor (NGF), whereas the catalytically active mutant did not. MK-STYX continued to induce neurites in the presence of a MEK (MAP kinase kinase) inhibitor suggesting that MK-STYX does not act through the Ras-ERK/MAPK pathway but is involved in another pathway whose inactivation leads to neuronal differentiation. RhoA activity assays indicated that MK-STYX induced extensions through the Rho signaling pathway. MK-STYX decreased RhoA activation, whereas RhoA activation increased when MK-STYX was down-regulated. Furthermore, MK-STYX affected downstream players of RhoA such as the actin binding protein cofilin. The presence of MK-STYX decreased the phosphorylation of cofilin in non NGF stimulated cells, but increased its phosphorylation in NGF stimulated cells, whereas knocking down MK-STYX caused an opposite effect. Taken together our data suggest that MK-STYX may be a regulator of RhoA signaling, and

  2. Business Jet

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Citation Jet, developed by Cessna Aircraft Company, Wichita, KS, is the first business jet to employ Langley Research Center's natural laminar flow (NLF) technology. NLF reduces drag and therefore saves fuel by using only the shape of the wing to keep the airflow smooth, or laminar. This reduces friction between the air and wing, and therefore, reduces drag. NASA's Central Industrial Applications Center, Rural Enterprises, Inc., Durant, OK, its Kansas affiliate, and Wichita State University assisted in the technology transfer.

  3. Measurement of the WW and WZ production cross section using final states with a charged lepton and heavy-flavor jets in the full CDF Run II data set

    DOE PAGES

    Aaltonen, T.; Amerio, S.; Amidei, D.; ...

    2016-08-23

    We present a measurement of the total WW and WZ production cross sections inmore » $$p\\bar{p}$$ collision at $$\\sqrt{s}$$ = 1.96 TeV, in a final state consistent with leptonic W boson decay and jets originating from heavy-flavor quarks from either a W or a Z boson decay. This analysis uses the full data set collected with the CDF II detector during Run II of the Tevatron collider, corresponding to an integrated luminosity of 9.4 fb-1. An analysis of the dijet mass spectrum provides 3.7σ evidence of the summed production processes of either WW or WZ bosons with a measured total cross section of σWW+WZ = 13.7±3.9 pb. Independent measurements of the WW and WZ production cross sections are allowed by the different heavy-flavor decay patterns of the W and Z bosons and by the analysis of secondary-decay vertices reconstructed within heavy-flavor jets. The productions of WW and of WZ dibosons are independently seen with significances of 2.9σ and 2.1σ, respectively, with total cross sections of σWW = 9.4±4.2 pb and σWZ = 3.7$$+2.5\\atop{-2.2}$$ pb. Lastly, the measurements are consistent with standard-model predictions.« less

  4. STS-42 Commander Grabe uses DTO 653 MK1 Rowing Machine on OV-103's middeck

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-42 Commander Ronald J. Grabe exercises using MK1 Rowing Machine on the middeck of Discovery, Orbiter Vehicle (OV) 103. Grabe is using the exercise device as part of Development Test Objective (DTO) 653, Evaluation of MK1 Rowing Machine. The forward lockers appear at Grabe's right and the sleep station behind him.

  5. Test report for K Basin MK I lid removal and replacement system

    SciTech Connect

    Omberg, R.P.; Roe, N.R.

    1996-08-21

    This report provides the results of acceptance testing of sampling equipment for use in the Hanford K Basin. The equipment, MK I Lid Removal/Replacement Tools, were designed to remove/replace MK I Spent Fuel Canister lids so that other equipment may be used to sample the canister contents. The tools were determined to be acceptable for their intended use.

  6. Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN).

    PubMed

    Xu, Chuanying; Zhu, Shunying; Wu, Mingyuan; Han, Wei; Yu, Yan

    2014-01-01

    Midkine (MK) and pleiotrophin (PTN) belong to the subfamily of heparin binding growth factors. They have ca. 50% structural homology, with similar C- and N-domains as well as comparable binding affinity to heparin, glycoproteins and proteoglycans. Both MK and PTN have diverse functions, such as mitogenicity, inflammation, angiogenesis, oncogenesis and stem cell self-renewal. The high expression of MK and PTN in many kinds of cancers makes them excellent as cancer biomarkers and targets for anticancer drug development. In addition, the important roles of MK and PTN in the regeneration of tissues, such as myocardium, cartilage, neuron, muscle, and bone, make them attractive candidates for the treatment of degenerative diseases such as myocardiac and cerebral infarction, Alzheimer's disease, Parkinson's disease and skeletal muscle injury. As a result, there has been a growing interest in the mechanisms of MK and PTN function, including the diverse receptors on the cell membrane and complex signal pathways in the cytoplasm. This work reviews the structures of MK and PTN, as well as the receptors and the intracellular signal pathways involving MK and PTN which will pave the way for future development of MK and PTN therapeutics.

  7. Jet-Induced Star Formation

    SciTech Connect

    van Breugel, W; Fragile, C; Anninos, P; Murray, S

    2003-12-16

    Jets from radio galaxies can have dramatic effects on the medium through which they propagate. We review observational evidence for jet-induced star formation in low ('FR-I') and high ('FR-II') luminosity radio galaxies, at low and high redshifts respectively. We then discuss numerical simulations which are aimed to explain a jet-induced starburst ('Minkowski's Object') in the nearby FR-I type radio galaxy NGC 541. We conclude that jets can induce star formation in moderately dense (10 cm{sup -3}), warm (10{sup 4} K) gas; that this may be more common in the dense environments of forming, active galaxies; and that this may provide a mechanism for 'positive' feedback from AGN in the galaxy formation process.

  8. {sup 3}He melting pressure temperature scale below 25 mK

    SciTech Connect

    Adams, E.D.; Ni, W.; Xia, J.S.

    1995-04-01

    Using {sup 60}Co {gamma} ray anisotropy radiation as a primary thermometer, with a Pt NMR susceptibility secondary thermometer, the authors have made high precision measurements of the {sup 3}He melting pressure versus temperature from 500 {mu}K to 25 mK. Temperatures obtained for the fixed points on the melting curve are: the superfluid A transition T{sub A} = 2.505 mK, the A-B transition T{sub AB} = 1.948 mK, and the solid ordering temperature T{sub N} = 0.934 mK. The authors provide a functional form for P(T), which, with the fixed points, constitutes a convenient temperature scale, based on a primary thermometer, usable to well below 1 mK.

  9. [Jet lag].

    PubMed

    Lagarde, D; Doireau, P

    1997-01-01

    Desynchronization of circadian rhythmicity resulting from rapid travel through at least four time zones leads to symptoms known in everyday English as jet-lag. The most detrimental effect of jet-lag is fatigue with poor alertness and psychomotor performance. Severity is subject to individual variation in susceptibility (morning/evening typology, age,...) and environmental factors (direction of travel, number of time zones crossed, psychosocial environment...). Many measures used to prevent or reduce jet lag are inappropriate or ineffective and some may even be dangerous, such as use of melatonin. One of the most reliable preventive techniques consists of reinforcing social synchronizers by maintaining exposure to sunlight and social activity. Only two drugs currently available on the market can be recommended, i.e. non-benzodiazepinic hypnotics which induce high quality sleep to allow quick recovery and a new time-release caffeine agent which has been shown to prolong psychomotor performance.

  10. The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation

    PubMed Central

    Hinton, Shantá D.; Myers, Michael P.; Roggero, Vincent R.; Allison, Lizabeth A.; Tonks, Nicholas K.

    2010-01-01

    MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein] is a pseudophosphatase member of the dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases). MK-STYX is catalytically inactive due to the absence of two amino acids from the signature motif that are essential for phosphatase activity. The nucleophilic cysteine residue and the adjacent histidine residue, which are conserved in all active dual-specificity phosphatases, are replaced by serine and phenylalanine residues respectively in MK-STYX. Mutations to introduce histidine and cysteine residues into the active site of MK-STYX generated an active phosphatase. Using MS, we identified G3BP1 [Ras-GAP (GTPase-activating protein) SH3 (Src homology 3) domain-binding protein-1], a regulator of Ras signalling, as a binding partner of MK-STYX. We observed that G3BP1 bound to native MK-STYX; however, binding to the mutant catalytically active form of MK-STYX was dramatically reduced. G3BP1 is also an RNA-binding protein with endoribonuclease activity that is recruited to ‘stress granules’ after stress stimuli. Stress granules are large subcellular structures that serve as sites of mRNA sorting, in which untranslated mRNAs accumulate. We have shown that expression of MK-STYX inhibited stress granule formation induced either by aresenite or expression of G3BP itself; however, the catalytically active mutant MK-STYX was impaired in its ability to inhibit G3BP-induced stress granule assembly. These results reveal a novel facet of the function of a member of the PTP family, illustrating a role for MK-STYX in regulating the ability of G3BP1 to integrate changes in growth-factor stimulation and environmental stress with the regulation of protein synthesis. PMID:20180778

  11. MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia

    PubMed Central

    Evans, Brian C.; Hocking, Kyle M.; Osgood, Michael J.; Voskresensky, Igor; Dmowska, Julia; Kilchrist, Kameron V.; Brophy, Colleen M.; Duvall, Craig L.

    2017-01-01

    Autologous vein grafts are commonly used for coronary and peripheral artery bypass but have a high incidence of intimal hyperplasia (IH) and failure. We present a nanopolyplex (NP) approach that efficiently delivers a mitogen-activated protein kinase (MAPK)–activated protein (MAPKAP) kinase 2 inhibitory peptide (MK2i) to graft tissue to improve long-term patency by inhibiting pathways that initiate IH. In vitro testing in human vascular smooth muscle cells revealed that formulation into MK2i-NPs increased cell internalization, endosomal escape, and intracellular half-life of MK2i. This efficient delivery mechanism enabled MK2i-NPs to sustain potent inhibition of inflammatory cytokine production and migration in vascular cells. In intact human saphenous vein, MK2i-NPs blocked inflammatory and migratory signaling, as confirmed by reduced phosphorylation of the posttranscriptional gene regulator heterogeneous nuclear ribonucleoprotein A0, the transcription factor cAMP (adenosine 3′,5′-monophosphate) element–binding protein, and the chaperone heat shock protein 27. The molecular effects of MK2i-NPs caused functional inhibition of IH in human saphenous vein cultured ex vivo. In a rabbit vein transplant model, a 30-min intraoperative graft treatment with MK2i-NPs significantly reduced in vivo IH 28 days posttransplant compared with untreated or free MK2i–treated grafts. The decrease in IH in MK2i-NP–treated grafts in the rabbit model also corresponded with decreased cellular proliferation and maintenance of the vascular wall smooth muscle cells in a more contractile phenotype. These data indicate that nanoformulated MK2 inhibitors are a promising strategy for preventing graft failure. PMID:26062847

  12. Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo

    SciTech Connect

    Suzuki, Tomohito; Momoi, Kanae; Hosoyamada, Makoto Kimura, Masaki; Shibasaki, Toshiaki

    2008-03-15

    Divalent metal transporter 1 (DMT1) is a mammalian iron (Fe) transporter and also transports Cadmium (Cd) in vitro. This study compared Cd absorption in DMT1-dysfunctional MK/Rej-{sup mk}/{sub mk} mice (mk/mk mice) and in DMT1-functional, Fe-deficient wild-type (WT) mice, to clarify the role of DMT1 in intestinal Cd absorption in vivo. Mice were given 1 ppm CdCl{sub 2} aq in drinking water for 2 weeks, and the concentrations of Cd and Fe in liver, kidney, and intestinal epithelium were subsequently determined. The Fe concentration in intestinal epithelia of WT mice was decreased in proportion to the level of dietary Fe limitation, while Cd accumulation under the same conditions was increased. DMT1 mRNA expression in the small intestine of Fe-deficient WT mice was clearly increased compared to that in Fe-sufficient WT mice. Iron deficiency resulted in up-regulation of Cd uptake in the intestine of Fe-deficient WT mice. The mk/mk mice have a mutation in DMT1 and loss of its function led to decreased intestinal Fe concentration. However, intestinal Cd accumulation was the same as in WT mice and it was also increased in Fe-deficient situation. There is the possibility that an unknown Cd pathway has taken a role on Cd intestinal absorption in vivo and that this pathway is regulated by food Fe concentrations. Therefore, DMT1 is not the sole transporter of intestinal cadmium absorption in vivo.

  13. Results of W-87/Mk21 Deployment Separation Shock Tests

    SciTech Connect

    Avalle, C.A.

    1999-04-21

    This report summarizes results of the W-87/Mk21 Deployment Separation Shock Tests conducted at the Survivability and Vulnerability Integration Center (SVIC) Hill Air Force Base in Ogden, Utah, from 10/5/98 to 10/8/98. Specific details regarding the test plan and procedures can be found in the Master Test Plan listed in the references. Test Objectives: (1) Evaluate the performance of a set of servo accelerometers during and post Re-entry Vehicle (RV) separation events. These ultra-sensitive accelerometers ({mu}g) needed operate during and after the separation shock events and these tests would serve as confirmation of proper functioning. These sensors were later flown on FrU-15, a development flight unit supporting the Instrumented High Fidelity Joint Test Assembly Program, as part of an experimental Inertial Measurement Unit (IMU) measure RV dynamics during RV mechanical separation and spin-up. (2) Measure separation shock response at the IMU accelerometer locations. (3) Measure separation shock response at locations on the warhead and RV common to locations used on MMIII separation tests conducted at LMMS Valley Forge for data comparison.

  14. The PIT MkV pulsed inductive thruster

    NASA Astrophysics Data System (ADS)

    Dailey, C. Lee; Lovberg, Ralph H.

    1993-07-01

    The pulsed inductive thruster (PIT) is an electrodeless, magnetic rocket engine that can operate with any gaseous propellant. A puff of gas injected against the face of a flat (spiral) coil is ionized and ejected by the magnetic field of a fast-rising current pulse from a capacitor bank discharge. Single shot operation on an impulse balance has provided efficiency and I(sub sp) data that characterize operation at any power level (pulse rate). The 1-m diameter MkV thruster concept offers low estimated engine mass at low powers, together with power capability up to more than 1 MW for the 1-m diameter design. A 20 kW design estimate indicates specific mass comparable to Ion Engine specific mass for 10,000 hour operation, while a 100,000 hour design would have a specific mass 1/3 that of the Ion Engine. Performance data are reported for ammonia and hydrazine. With ammonia, at 32 KV coil voltage, efficiency is a little more than 50 percent from 4000 to more than 8000 seconds I(sub sp). Comparison with data at 24 and 28 kV indicates that a wider I(sub sp) range could be achieved at higher coil voltages, if required for deep space missions.

  15. The PIT MkV pulsed inductive thruster

    NASA Technical Reports Server (NTRS)

    Dailey, C. Lee; Lovberg, Ralph H.

    1993-01-01

    The pulsed inductive thruster (PIT) is an electrodeless, magnetic rocket engine that can operate with any gaseous propellant. A puff of gas injected against the face of a flat (spiral) coil is ionized and ejected by the magnetic field of a fast-rising current pulse from a capacitor bank discharge. Single shot operation on an impulse balance has provided efficiency and I(sub sp) data that characterize operation at any power level (pulse rate). The 1-m diameter MkV thruster concept offers low estimated engine mass at low powers, together with power capability up to more than 1 MW for the 1-m diameter design. A 20 kW design estimate indicates specific mass comparable to Ion Engine specific mass for 10,000 hour operation, while a 100,000 hour design would have a specific mass 1/3 that of the Ion Engine. Performance data are reported for ammonia and hydrazine. With ammonia, at 32 KV coil voltage, efficiency is a little more than 50 percent from 4000 to more than 8000 seconds I(sub sp). Comparison with data at 24 and 28 kV indicates that a wider I(sub sp) range could be achieved at higher coil voltages, if required for deep space missions.

  16. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886.

    PubMed Central

    Kehrer, J P; Biswal, S S; La, E; Thuillier, P; Datta, K; Fischer, S M; Vanden Heuvel, J P

    2001-01-01

    Although MK886 was originally identified as an inhibitor of 5-lipoxygenase activating protein (FLAP), recent data demonstrate that this activity does not underlie its ability to induce apoptosis [Datta, Biswal and Kehrer (1999) Biochem. J. 340, 371--375]. Since FLAP is a fatty-acid binding protein, it is conceivable that MK886 may affect other such proteins. A family of nuclear receptors that are activated by fatty acids and their metabolites, the peroxisome-proliferator-activated receptors (PPARs), have been implicated in apoptosis and may represent a target for MK886. The ability of MK886 to inhibit PPAR-alpha, -beta and -gamma activity was assessed using reporter assay systems (peroxisome-proliferator response element--luciferase). Using a transient transfection system in monkey kidney fibroblast CV-1 cells, mouse keratinocyte 308 cells and human lung adenocarcinoma A549 cells, 10--20 microM MK886 inhibited Wy14,643 activation of PPAR alpha by approximately 80%. Similar inhibition of PPAR alpha by MK886 was observed with a stable transfection reporter system in CV-1 cells. Only minimal inhibitory effects were seen on PPAR beta and PPAR gamma. MK886 inhibited PPAR alpha by a non-competitive mechanism as shown by its effects on the binding of arachidonic acid to PPAR alpha protein, and a dose-response study using a transient transfection reporter assay in COS-1 cells. An assay assessing PPAR ligand-receptor interactions showed that MK886 prevents the conformational change necessary for active-complex formation. The expression of keratin-1, a protein encoded by a PPAR alpha-responsive gene, was reduced by MK886 in a culture of mouse primary keratinocytes, suggesting that PPAR inhibition has functional consequences in normal cells. Although Jurkat cells express all PPAR isoforms, various PPAR alpha and PPAR gamma agonists were unable to prevent MK886-induced apoptosis. This is consistent with MK886 functioning as a non-competitive inhibitor of PPAR alpha, but may

  17. Development and Initial Review of the Mark II Navy 44 Sail Training Craft

    DTIC Science & Technology

    2009-03-01

    intensive training environment) • Offshore capability for trips to Bermuda with a semi-skilled crew of ten • Favorable treatment under existing rating... triangle and headsails • Existing systems by type, to be updated as directed Features to be improved: • Construction materials, scantlings and...consistent with the MK I’s. The mast height, standing rigging and fore triangle base had to be identical between the MK I and MK II. However, PYD wanted

  18. Jet Dipolarity: Top Tagging with Color Flow

    SciTech Connect

    Hook, Anson; Jankowiak, Martin; Wacker, Jay G.; /SLAC

    2011-08-12

    A new jet observable, dipolarity, is introduced that can distinguish whether a pair of subjets arises from a color singlet source. This observable is incorporated into the HEPTopTagger and is shown to improve discrimination between top jets and QCD jets for moderate to high p{sub T}. The impressive resolution of the ATLAS and CMS detectors means that a typical QCD jet at the LHC deposits energy in {Omicron}(10-100) calorimeter cells. Such fine-grained calorimetry allows for jets to be studied in much greater detail than previously, with sophisticated versions of current techniques making it possible to measure more than just the bulk properties of jets (e.g. event jet multiplicities or jet masses). One goal of the LHC is to employ these techniques to extend the amount of information available from each jet, allowing for a broader probe of the properties of QCD. The past several years have seen significant progress in developing such jet substructure techniques. A number of general purpose tools have been developed, including: (i) top-tagging algorithms designed for use at both lower and higher p{sub T} as well as (ii) jet grooming techniques such as filtering, pruning, and trimming, which are designed to improve jet mass resolution. Jet substructure techniques have also been studied in the context of specific particle searches, where they have been shown to substantially extend the reach of traditional search techniques in a wide variety of scenarios, including for example boosted Higgses, neutral spin-one resonances, searches for supersymmetry, and many others. Despite these many successes, however, there is every reason to expect that there remains room for refinement of jet substructure techniques.

  19. Identification of Statistical Invariance for Anodic Signals of Mk-IV Electrorefiner

    SciTech Connect

    Supathorn Phongikaroon; Tae-Sic Yoo

    2007-09-01

    A statistical invariance technique is proposed for an analysis of anodic signals from the Mk-IV electrorefiner (ER) currently used for treating spent EBR-II fuel. Voltage and applied current signals obtained from the Data Archival Software System (DASS) were used in this study. In general, the plots of these signals from different experimental runs present complex patterns to analyze—the currents were adjusted and shut-off due to limited ampere-hr or cut-off cell voltage; the voltage would increase showing a sign that uranium in the fuel elements had been depleted. Rather than directly analyzing these sets of time-series signals, a simple nonlinear function of these signal sequences and division were observed, which returned resistance series information. The primary idea deriving the methodology presented in this paper is that “anodic resistance time series should show intrinsic kinetic progress of anodic ER process.” A simple histogram-based analysis reveals notable statistical information, which may be invariant under ideal ER operating conditions. For instance, the results suggest that mostly uranium dissolution would be preferentially transferred around 0.00217 - 0.00354 ohm and other minor distribution peaks may possibly represent other transfers of fission species in the system.

  20. Negative modulation of α5 GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion

    PubMed Central

    Stamenić, Tamara Timić; Joksimović, Srdjan; Biawat, Poonam; Stanković, Tamara; Marković, Bojan; Cook, James M; Savić, Miroslav M

    2016-01-01

    Reportedly, negative modulation of α5 GABAA receptors may improve cognition in normal and pharmacologically-impaired animals, and such modulation has been proposed as an avenue for treatment of cognitive symptoms in schizophrenia. This study assessed the actions of PWZ-029, administered at doses (2, 5 and 10 mg/kg) at which it reached micromolar concentrations in brain tissue with estimated free concentrations adequate for selective modulation of α5 GABAA receptors, in three cognitive tasks in male Wistar rats acutely treated with the noncompetitive N-methyl-D-aspartate – receptor antagonist, MK-801 (0.1 mg/kg), as well in tests of locomotor activity potentiated by MK-801 (0.2 mg/kg) or amphetamine (0.5 mg/kg). In a hormetic-like manner, only 5 mg/kg PWZ-029 reversed MK-801-induced deficits in novel object recognition test (visual recognition memory), whereas in the Morris water maze, the 2 mg/kg dose of PWZ-029 exerted partial beneficial effects on spatial learning impairment. PWZ-029 did not affect recognition memory deficits in social novelty discrimination procedure. Motor hyperactivity induced with MK-801 or amphetamine was not preventable by PWZ-029. Our results show that certain MK-801-induced memory deficits can be ameliorated by negative modulation of α5 GABAA receptors, and point to the need for further elucidation of their translational relevance to cognitive deterioration in schizophrenia. PMID:26105958

  1. Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes.

    PubMed Central

    Moring, J; Niego, L A; Ganley, L M; Trumbore, M W; Herbette, L G

    1994-01-01

    MK-801, a noncompetitive antagonist of the NMDA (N-methyl-D-aspartate) receptor, has protective effects against excitotoxicity and ethanol withdrawal seizures. We have determined membrane/buffer partition coefficients (Kp[mem]) of MK-801 and its rates of association with and dissociation from membranes. Kp[mem] (+/- SD) = 1137 (+/- 320) in DOPC membranes and 485 (+/- 99) in synaptoneurosomal (SNM) lipid membranes from rat cerebral cortex (unilamellar vesicles). In multilamellar vesicles, Kp[mem] was higher: 3374 (+/- 253) in DOPC and 6879 (+/- 947) in SNM. In cholesterol/DOPC membranes, Kp[mem] decreased as the cholesterol content increased. MK-801 associated with and dissociated from membranes rapidly. Addition of ethanol to SNM did not affect Kp[mem]. MK-801 decreased the cooperative unit size of DMPC membranes. The decrease was smaller than that caused by 1,4-dihydropyridine drugs, indicating a weaker interaction with the hydrocarbon core. Small angle x-ray diffraction, with multilayer autocorrelation difference function modeling, indicated that MK-801 in a cholesterol/DOPC membrane (mole ratio = 0.6) causes a perturbation at approximately 16.0 A from the bilayer center. In bilayers of cholesterol/DOPC = 0.15 (mole ratio) or pure DOPC, the perturbation caused by MK-801 was more complex. The physical chemical interactions of MK-801 with membranes in vitro are consistent with a fast onset and short duration of action in vivo. PMID:7696477

  2. New insights into the activation, interaction partners and possible functions of MK5/PRAK.

    PubMed

    Perander, Maria; Keyse, Stephen M; Seternes, Ole-Morten

    2016-01-01

    MAP kinase-activated protein kinase 5 (MK5) was first described as a downstream target of the p38 MAP kinase pathway leading to its alternative acronym of p38-regulated/activated protein kinase (PRAK). However, since the discovery that MK5 is a bona fide interaction partner of the atypical MAP kinases ERK3 and ERK4 and that this interaction leads to both the activation and subcellular relocalisation of MK5, there has been considerable debate as to the relative roles of these MAPK pathways in mediating the activation and biological functions of MK5. Here we discuss recent progress in defining novel upstream components of the ERK3/ERK4 signalling pathway, our increased understanding of the mechanism by which MK5 interacts with and is activated by ERK3 and ERK4, and the discovery of novel interaction partners for MK5. Finally, we review recent literature that suggests novel biological functions for MK5 in a range of physiological and pathophysiological conditions including neuronal function and cancer.

  3. The effect of human cytomegalovirus on the formation of CFU-MK in vitro.

    PubMed

    Yao, Junxia; Song, Sanjun; Hu, Lihua

    2004-01-01

    To investigate the mechanism and the suppressive effect of human cytomegalovirus (HCMV) on colony forming unit-megakaryocyte (CFU-MK), semi-solid culture system was used to observe the effect of HCMV AD169 strain on CFU-MK's growth of 18 cord blood samples. HCMV DNA and immediate early (IE) protein mRNA in CFU-MK was detected by PCR and reverse transcription-polymerase chain reaction (RT-PCR). Our results showed that HCMV AD169 significantly suppressed the formation of CFU-MK in vitro. Compared with the mock group, the CFU-MK colonies decreased by 21.6%, 33.8% and 46.3%, respectively, in all the 3 infected groups (P<0.05), suggesting the suppression and the titer of the virus was dose-dependent. Both HCMV DNA and the expression of HCMV IE protein mRNA were positively detected in the colony cells of viral infected group. It is concluded that HCMV AD169 strain could inhibit the differentiation and proliferation of CFU-MK by directly infecting their progenitors. There was early transcription of HCMV IE protein in CFU-MK infected by virus.

  4. Evaluation of the angiogenic potency of a novel exopolysaccharide produced by the MK1 bacterial strain.

    PubMed

    Park, Ji-Yun; Kim, Beom Su; Lee, Jun

    2016-09-01

    Angiogenesis is an essential physiological step in wound healing and other regenerative processes. Here, we evaluated the angiogenic properties of an exopolysaccharide (EPS) secreted by MK1 (MK1-EPS), a novel bacterial strain isolated from Neungee mushrooms. MK1-EPS significantly increased human umbilical vein endothelial cell (HUVEC) proliferation, migration, and vascular tube formation. MK1-EPS enhanced the phosphorylation of extracellular signal-related kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, which are mitogen-activated protein kinases. In addition, the expression of p21 and intercellular adhesion molecule 1 (ICAM1), and phosphorylation of signal transducer and activator of transcription 3 (STAT3), but not of protein kinase B (AKT), were increased. Specific inhibitors of p38 (SB203580), ERK (PD98059), and JNK (SP600125) inhibited MK1-EPS-induced HUVEC proliferation, tube formation, and cell migration, and partially attenuated MKI-EPS-induced expression of p21 and ICAM1, and STAT3 phosphorylation. After surgical implantation into rabbit calvarial bone defects, new blood vessel formation was significantly higher with MK1-EPS composite bone granules than with granules alone, and new bone formation increased significantly. Therefore, MK1-EPS induces angiogenesis and may have potential for use as a bone regeneration agent in bone tissue engineering applications.

  5. NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia

    PubMed Central

    Olszewski, R T; Janczura, K J; Ball, S R; Madore, J C; Lavin, K M; Lee, J C-M; Lee, M J; Der, E K; Hark, T J; Farago, P R; Profaci, C P; Bzdega, T; Neale, J H

    2012-01-01

    The most widely validated animal models of the positive, negative and cognitive symptoms of schizophrenia involve administration of d-amphetamine or the open channel NMDA receptor blockers, dizocilpine (MK-801), phencyclidine (PCP) and ketamine. The drug ZJ43 potently inhibits glutamate carboxypeptidase II (GCPII), an enzyme that inactivates the peptide transmitter N-acetylaspartylglutamate (NAAG) and reduces positive and negative behaviors induced by PCP in several of these models. NAAG is an agonist at the metabotropic glutamate receptor 3 (mGluR3). Polymorphisms in this receptor have been associated with expression of schizophrenia. This study aimed to determine whether two different NAAG peptidase inhibitors are effective in dopamine models, whether their efficacy was eliminated in GCPII knockout mice and whether the efficacy of these inhibitors extended to MK-801-induced cognitive deficits as assessed using the novel object recognition test. ZJ43 blocked motor activation when given before or after d-amphetamine treatment. (R,S)-2-phosphono-methylpentanedioic acid (2-PMPA), another potent NAAG peptidase inhibitor, also reduced motor activation induced by PCP or d-amphetamine. 2-PMPA was not effective in GCPII knockout mice. ZJ43 and 2-PMPA also blocked MK-801-induced deficits in novel object recognition when given before, but not after, the acquisition trial. The group II mGluR antagonist LY341495 blocked the effects of NAAG peptidase inhibition in these studies. 2-PMPA was more potent than ZJ43 in a test of NAAG peptidase inhibition in vivo. By bridging the dopamine and glutamate theories of schizophrenia with two structurally different NAAG peptidase inhibitors and demonstrating their efficacy in blocking MK-801-induced memory deficits, these data advance the concept that NAAG peptidase inhibition represents a potentially novel antipsychotic therapy. PMID:22850437

  6. Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.

    PubMed

    Chang, Minsun; Park, Seol-Rin; Kim, Juhyun; Jang, Mijung; Park, Jeong Hyun; Park, Ji Eun; Park, Hyeung-Geun; Suh, Young-Ger; Jeong, Yeon Su; Park, Young-Ho; Kim, Hee-Doo

    2010-01-01

    In searching for opportunities to exploit the benefits of silicon in TRPV1 research, we tried to investigate the pharmacological effects of sila-substitution (C/Si exchange) of tert-butyl group in the MK-056 series. Compound 13a, with a 4-positioned trimethylsilanyl group on the B ring in place of tert-butyl group, exhibited the most potent antagonist activity with IC(50) values of 0.15 microM, which is almost equipotent with that of MK-056. This is the first example that tert-butyl group on MK-056 series can be replaced to the other substituent without loss of activity.

  7. Magnetic measurements of CeAl sub 3 to below 1 mK

    SciTech Connect

    Avenel, O.; Xia, J.S.; Andraka, B.; Jee, C.S.; Xu, M.; Qian, Y.J.; Lang, T.; Moyland, P.L.; Ni, W.; Signore, P.J.C.; Adams, E.D.; Ihas, G.G.; Meisel, M.W.; Stewart, G.R.; Sullivan, N.S.; Takano, Y. )

    1992-03-01

    The magnetic susceptibility of a polycrystalline, single-phase sample of CeAl{sub 3} has been measured from 10 K to below 800 {mu}K. Above 40 mK, the temperature dependence of the susceptibility is consistent with the results of other groups and possesses a broad peak around 500 mK. Using standard rf superconducting-quantum-interference-device detection techniques operating at 16 Hz, the sample, which was located in a shielded environment having a residual static field of less than 2 nT, was not observed to show any magnetic anomaly from 40 mK down to the lowest achievable temperature.

  8. Measurement of the acoustic properties of amorphous silica above 4.5 mK

    NASA Astrophysics Data System (ADS)

    Nazaretski, E.; Merithew, R. D.; Pohl, R. O.; Parpia, J. M.

    2005-04-01

    Measurements of speed of sound and internal friction of a-SiO2 were extended down to ≈4mK (sample temperature) in a cryostat shielded with lead against γ radiation. We conclude that the sample starts to thermally decouple below 8mK primarily due to internal heat release. Down to 10mK , the speed of sound is shown to be compatible with the predictions of the tunneling model, with no evidence seen for a low energy cut-off of the tunnel splitting, contrary to our earlier claims.

  9. Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats.

    PubMed

    Chen, Z; Zhao, Q; Sugimoto, Y; Fujii, Y; Kamei, C

    1999-08-21

    The effects of histamine on the spatial memory deficits induced by MK-801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H(1)-receptors.

  10. Weak-value thermostat with 0.2 mK precision.

    PubMed

    Egan, Patrick; Stone, Jack A

    2012-12-01

    A new laser-based thermostat sensitive to 0.2 mK at room temperature is reported. The method utilizes a fluid-filled prism and interferometric weak-value amplification to sense nanoradian deviations of a laser beam: due to the high thermo-optic coefficient of the fluid (colorless fluorocarbon), the deviation angle through the prism is sensitive to temperature. We estimate the daily stability of our device to be 0.2 mK, which is limited by drifts in the apparatus, and the narrow 20 mK capture range is the price paid for the weak measurement.

  11. Fatigue Testing of the MK3 Mod0 2000 Lb Bail Lugs: Test Report

    DTIC Science & Technology

    1990-08-01

    REPORT REQUESTING AUTHORITY: No. 1 Central Ammunition Depot, RAAF ITEMS TESTED: Sixty one MK3 MODO 2000 lb bail lugs from four different lot numbers SUMMARY...identifying run-out, lugs from lot numbers I and 4 shall be used due to the availability of a larger quantity of these lugs in comparison to the others. 5...to lugs from four different lot numbers as follows: F1/*t = MK3 MODO (ET) 30003-1380540 ETW-1 277 F2/** = MK3 MODO 30003-1380540 SMN81J 001008 F3

  12. Filament Eruptions, Jets, and Space Weather

    NASA Technical Reports Server (NTRS)

    Moore, Ronald; Sterling, Alphonse; Robe, Nick; Falconer, David; Cirtain, Jonathan

    2013-01-01

    Previously, from chromospheric H alpha and coronal X-ray movies of the Sun's polar coronal holes, it was found that nearly all coronal jets (greater than 90%) are one or the other of two roughly equally common different kinds, different in how they erupt: standard jets and blowout jets (Yamauchi et al 2004, Apl, 605, 5ll: Moore et all 2010, Apj, 720, 757). Here, from inspection of SDO/AIA He II 304 A movies of 54 polar x-ray jets observed in Hinode/XRT movies, we report, as Moore et al (2010) anticipated, that (1) most standard x-ray jets (greater than 80%) show no ejected plasma that is cool enough (T is less than or approximately 10(exp 5K) to be seen in the He II 304 A movies; (2) nearly all blownout X-ray jets (greater than 90%) show obvious ejection of such cool plasma; (3) whereas when cool plasma is ejected in standard X-ray jets, it shows no lateral expansion, the cool plasma ejected in blowout X-ray jets shows strong lateral expansion; and (4) in many blowout X-ray jets, the cool plasma ejection displays the erupting-magnetic-rope form of clasic filament eruptions and is thereby seen to be a miniature filament eruption. The XRT movies also showed most blowout X-ray jets to be larger and brighter, and hence to apparently have more energy, than most standard X-ray jets. These observations (1) confirm the dichotomy of coronal jets, (2) agree with the Shibata model for standard jets, and (3) support the conclusion of Moore et al (2010) that in blowout jets the magnetic-arch base of the jet erupts in the manner of the much larger magnetic arcades in which the core field, the field rooted along the arcade's polarity inversion line, is sheared and twisted (sigmoid), often carries a cool-plasma filament, and erupts to blowout the arcade, producing a CME. From Hinode/SOT Ca II movies of the polar limb, Sterling et al (2010, ApJ, 714, L1) found that chromospheric Type-II spicules show a dichotomy of eruption dynamics similar to that found here for the cool

  13. Systemic hyperthermia masks the neuroprotective effects of MK-801, but not rosiglitazone in brain ischaemia.

    PubMed

    Nategh, Mohsen; Shaveisi, Kaveh; Shabanzadeh, Alireza P; Sadr, Seyed Sh; Parviz, Mohsen; Ghabaei, Mojdeh

    2010-09-01

    The use of neuroprotective agents has been under investigation for the treatment of ischaemic brain stroke. In this study, we examined the effects of rosiglitazone and MK-801, two potential neuroprotectants, on thromboembloic focal stroke in hyperthermic rats. The animals were assigned into groups of rosiglitazone, MK-801 and control, all under both normothermic and hyperthermic conditions. A focal ischaemia was induced by injection of preformed clot into the origin of the middle cerebral artery. The animals were assessed by measuring infarct size and brain oedema and also evaluating neurological deficit and seizure activity. Rosiglitazone improved infarct volume and neurological deficit in both normo- (36%) and hyperthermic (63%) animals; but MK-801 only improved normothermic animals. Our results do not support the use of MK-801 in hyperthermic conditions of brain stroke but suggest that rosiglitazone may preserve its efficiency even in hyperthermia.

  14. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

    PubMed

    Anderson, David R; Meyers, Marvin J; Vernier, William F; Mahoney, Matthew W; Kurumbail, Ravi G; Caspers, Nicole; Poda, Gennadiy I; Schindler, John F; Reitz, David B; Mourey, Robert J

    2007-05-31

    A new class of potent kinase inhibitors selective for mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) for the treatment of rheumatoid arthritis has been prepared and evaluated. These inhibitors have IC50 values as low as 10 nM against the target and have good selectivity profiles against a number of kinases including CDK2, ERK, JNK, and p38. These MK-2 inhibitors have been shown to suppress TNFalpha production in U397 cells and to be efficacious in an acute inflammation model. The structure-activity relationships of this series, the selectivity for MK-2 and their activity in both in vitro and in vivo models are discussed. The observed selectivity is discussed with the aid of an MK-2/inhibitor crystal structure.

  15. MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.

    PubMed

    Lu, Jeng-Wei; Lin, Yu-Min; Lai, Yen-Ling; Chen, Chien-Yuan; Hu, Chung-Yi; Tien, Hwei-Fang; Ou, Da-Liang; Lin, Liang-In

    2015-07-01

    Genetic alterations in the PI3K/AKT cascade have been linked to various human cancers including acute myeloid leukemia (AML) and have emerged to be promising targets for treatment. In this study, we explored the molecular mechanism and clinical implication of a specific allosteric AKT inhibitor, MK-2206, in the treatment of AML. Four leukemia cell lines, MV-4-11, MOLM-13, OCI/AML3, and U937, were used. Apoptosis and cell cycle distribution were determined by flow cytometry analysis. Expression of anti-apoptotic protein family and glycogen synthase kinase 3β (GSK3β) signaling was determined by western blotting. Drug combination effects of MK-2206 with cytarabine were evaluated by cell proliferation assay, and the combination index values were calculated by CompuSyn software. MK-2206 had no effect on normal peripheral blood mononuclear cells, but induced G1-phase arrest and apoptosis in leukemia cells. Among anti-apoptotic Bcl-2 family members, only myeloid cell leukemia-1 (Mcl-1) was significantly suppressed. Mcl-1 suppression by MK-2206 was closely associated with decreased GSK3β phosphorylation at Ser9, an event leads to GSK3β activation. Furthermore, the effect of MK-2206 on Mcl-1 downregulation was abolished by GSK3β inhibitor, lithium chloride and proteasome inhibitor, MG-132, suggesting that MK-2206 acted through a GSK3β-mediated, proteasome-dependent protein degradation. In addition, co-administration of MK-2206 with cytarabine could enhance the cytotoxic efficacy of cytarabine in leukemia cell lines. In conclusion, we have demonstrated that MK-2206 is an active agent in AML and its efficacy as in combination with cytarabine is implicated.

  16. Heat Capacity Setup for Superconducting Bolometer Absorbers below 400 mK

    NASA Astrophysics Data System (ADS)

    Singh, V.; Mathimalar, S.; Dokania, N.; Nanal, V.; Pillay, R. G.; Ramakrishnan, S.

    2014-05-01

    A calorimeter set up with very low heat capacity (20 nJ/K at 100 mK) has been designed using commercial Carbon based resistors. This calorimeter is used to determine the heat capacity of small samples of superconducting bolometer absorbers. In particular, we present heat capacity studies of Tin, a bolometer candidate for Neutrinoless Double Beta Decay in Sn, in the temperature range of 60-400 mK.

  17. Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia.

    PubMed

    Gururajan, Anand; Taylor, David Alan; Malone, Daniel Thomas

    2011-09-23

    Cannabidiol is a non-psychoactive phytocannabinoid which, based on several previous preclinical and clinical reports, is purported to have antipsychotic potential. The purpose of this investigation was to further investigate if these effects would be seen using an MK-801-induced rat model of aspects of schizophrenia. MK-801 is an NMDA receptor-antagonist known to produce hyperactivity, deficits in prepulse inhibition and social withdrawal, behaviours which correlate well with some of the positive, cognitive and negative symptoms of schizophrenia. Following a 4-day acclimatisation to the holding room, rats were acclimatised to startle chambers on day 5 and their prepulse inhibition (PPI) determined on day 6 following treatment with cannabidiol or vehicle and MK-801 or vehicle. On day 9, rats were acclimatised to the social interaction testing arena and on day 10, were tested for social interaction and locomotor activity following the same treatments. Cannabidiol treatment alone disrupted PPI and produced hyperactivity but had no effect on social behaviour. Cannabidiol had no effect on MK-801-induced disruption of PPI or hyperactivity but showed potential towards inhibiting MK-801-induced social withdrawal. As a comparator, we also tested the effect of the atypical antipsychotic clozapine which only partially reversed MK-801-induced disruption of PPI but was able to reverse MK-801-induced hyperactivity and social withdrawal. In conclusion, cannabidiol showed both propsychotic activity and partial antipsychotic activity in an MK-801-induced model of aspects of schizophrenia. Further behavioural studies would be required using a range of species, strains, animal models and testing paradigms to conclusively establish the antipsychotic potential of cannabidiol.

  18. Top Jets at the LHC

    SciTech Connect

    Almeida, L.G.; Lee, S.J.; Perez, G.; Sung, I.; Virzi, J.

    2008-10-06

    We investigatethe reconstruction of high pT hadronically-decaying top quarksat the Large Hadron Collider. One of the main challenges in identifying energetictop quarks is that the decay products become increasingly collimated. This reducesthe efficacy of conventional reconstruction methods that exploit the topology of thetop quark decay chain. We focus on the cases where the decay products of the topquark are reconstructed as a single jet, a"top-jet." The most basic"top-tag" methodbased on jet mass measurement is considered in detail. To analyze the feasibility ofthe top-tagging method, both theoretical and experimental aspects of the large QCDjet background contribution are examined. Based on a factorization approach, wederive a simple analytic approximation for the shape of the QCD jet mass spectrum.We observe very good agreement with the Monte Carlo simulation. We consider high pT tt bar production in the Standard Model as an example, and show that our theoretical QCD jet mass distributions can efficiently characterize the background via sideband analyses. We show that with 25 fb-1 of data, our approach allows us to resolve top-jets with pT _> 1 TeV, from the QCD background, and about 1.5 TeV top-jets with 100 fb-1, without relying on b-tagging. To further improve the significancewe consider jet shapes (recently analyzed in 0807.0234 [hep-ph]), which resolve thesubstructure of energy flow inside cone jets. A method of measuring the top quarkpolarization by using the transverse momentum of the bottom quark is also presented.The main advantages of our approach are: (i) the mass distributions are driven byfirst principle calculations, instead of relying solely on Monte Carlo simulation; (ii) for high pT jets (pT _> 1 TeV), IR-safe jet shape variables are robust against detectorresolution effects. Our analysis can be applied to other boosted massive particlessuch as the electroweak gauge bosons and the Higgs.

  19. Realization of PLTS-2000 for Low-Temperature Resistance Thermometer Calibration Services Below 650 mK

    NASA Astrophysics Data System (ADS)

    Nakagawa, Hisashi

    2016-11-01

    In this study, the Provisional Low Temperature Scale of 2000 (PLTS-2000) was realized below 650 mK for the purpose of launching low-temperature resistance thermometer calibration services in Japan. A Straty-Adams-type 3He melting pressure thermometer (MPT) and a dilution refrigerator were used to realize the PLTS-2000. Offsets due to hydrostatic pressure head in a filling capillary line of the MPT were adjusted using the minimum pressure fixed point on the 3He melting curve. A rather large MPT hysteresis between the decreasing and increasing pressures was observed during pressure calibration of the MPT and was the main source of uncertainty. The combined standard uncertainty (k = 1) between 50 mK and 650 mK was estimated to be in the range of 0.40 mK to 2.62 mK. The MPT and a number of resistance thermometers with negative temperature coefficients were mounted on the experimental platform with a thermal connection to a mixing chamber and compared in a multiple-temperature-point calibration. The temperature range around the melting pressure minimum, 250 mK to 400 mK, was not used for the calibration. The expanded uncertainty (k = 2) in the calibration based on realization of the PLTS-2000 between 50 mK and 650 mK was estimated to be in the range of 0.86 mK to 5.25 mK.

  20. Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.

    PubMed

    Qin, Jun; Dhondi, Pawan; Huang, Xianhai; Aslanian, Robert; Fossetta, James; Tian, Fang; Lundell, Daniel; Palani, Anandan

    2012-02-09

    Inhibition of MK2 has been shown to offer advantages over that of p38 MAPK in the development of cures for inflammatory diseases such as arthritis. P38 MAPK knockout in mice was lethal, whereas MK2-null mice demonstrated strong inhibition of disease progression in collagen-induced arthritis and appeared normal and viable. However, it is challenging to develop ATP-competitive MK2 inhibitors due to high ATP binding affinity to the kinase. Non-ATP-competitive MK2 inhibitors interact and bind to the kinase in a mode independent of ATP concentration, which could provide better selectivity and cellular potency. Therefore, it is desirable to identify non-ATP-competitive MK2 inhibitors. Through structure optimization of lead compound 1, a novel series of dihydrooxadiazoles was discovered. Additional structure-activity relationship (SAR) study of this series led to the identification of compound 38 as a non-ATP-competitive MK2 inhibitor with potent enzymatic activity and good cellular potency. The SAR, synthesis, and biological data of dihydrooxadiazole series are discussed.

  1. Calcium and ZmCCaMK are involved in brassinosteroid-induced antioxidant defense in maize leaves.

    PubMed

    Yan, Jingwei; Guan, Li; Sun, Yue; Zhu, Yuan; Liu, Lei; Lu, Rui; Jiang, Mingyi; Tan, Mingpu; Zhang, Aying

    2015-05-01

    Brassinosteroids (BRs) have been shown to enhance stress tolerance by inducing antioxidant defense systems. However, the mechanisms of BR-induced antioxidant defense in plants remain to be determined. In this study, the role of calcium (Ca(2+)) and maize calcium/calmodulin-dependent protein kinase (CCaMK), ZmCCaMK, in BR-induced antioxidant defense, and the relationship between ZmCCaMK and Ca(2+) in BR signaling were investigated. BR treatment led to a significant increase in cytosolic Ca(2+) concentration in protoplasts from maize mesophyll, and Ca(2+) was shown to be required for BR-induced antioxidant defense. Treatment with BR induced increases in gene expression and enzyme activity of ZmCCaMK in maize leaves. Transient overexpression and silencing of ZmCCaMK in maize protoplasts demonstrated that ZmCCaMK was required for BR-induced antioxidant defense. The requirement for CCaMK was further investigated using a loss-of-function mutant of OsCCaMK, the orthologous gene of ZmCCaMK in rice. Consistent with the findings in maize, BR treatment could not induce antioxidant defense in the rice OsCCAMK mutant. Furthermore, Ca(2+) was required for BR-induced gene expression and activation of ZmCCaMK, while ZmCCaMK was shown to enhance the BR-induced increase in cytosolic Ca(2+) concentration. Moreover, our results also showed that ZmCCaMK and H2O2 influenced each other. These results indicate that Ca(2+) works together with ZmCCaMK in BR-induced antioxidant defense, and there are two positive feedback loops between Ca(2+) or H2O2 and ZmCCaMK in BR signaling in maize.

  2. Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2.

    PubMed

    Huh, Sung Un; Lee, Gil-Je; Jung, Ji Hoon; Kim, Yunsik; Kim, Young Jin; Paek, Kyung-Hee

    2015-01-23

    Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays an important role in diverse stress response of plants and is often useful to generate genetically engineered crop plants. In this study, we carried out functional characterization of CaWRKYa encoding group I WRKY member, which is induced during hypersensitive response (HR) in hot pepper (Capsicum annuum) upon Tobacco mosaic virus (TMV) infection. CaWRKYa was involved in L-mediated resistance via transcriptional reprogramming of pathogenesis-related (PR) gene expression and affected HR upon TMV-P0 infection. CaWRKYa acts as a positive regulator of this defense system and could bind to the W-box of diverse PR genes promoters. Furthermore, we found Capsicum annuum mitogen-activated protein kinase 1 (CaMK1) and 2 (CaMK2) interacted with CaWRKYa and phosphorylated the SP clusters but not the MAPK docking (D)-domain of CaWRKYa. Thus, these results demonstrated that CaWRKYa was regulated by CaMK1 and CaMK2 at the posttranslational level in hot pepper.

  3. Altitude Test Chamber Investigation of Performance of a 28-inch Ram-jet Engine II : Effects of Gutter Width and Blocked Area on Operating Range and Combustion Efficiency

    NASA Technical Reports Server (NTRS)

    Shillito, T B; Jones, W L; Kahn, R W

    1950-01-01

    Altitude-test-chamber investigation of effects of flame-holder blocked area and gutter width on performance of 28-inch diameter ram jet at simulated flight Mach number of 2.0 for altitudes from 40,000 to 55,000 feet was conducted at NACA Lewis laboratory. Ten flame holders investigated covered gutter widths from 1.00 to 2.50 inches and blocked areas from 40.5 to 62.0 percent of combustion-chamber area. Gutter width did not appreciably affect combustion efficiency. Increase in blocked area from 40 to 62 percent resulted in 5- to 10-percent increase in combustion efficiency. Increasing gutter width resulted in improvement in fuel-air-ratio operating range.

  4. Magnetic Untwisting in Most Solar X-Ray Jets

    NASA Technical Reports Server (NTRS)

    Moore, Ronald; Sterling, Alphonse; Falconer, David; Robe, Dominic

    2013-01-01

    From 54 X-ray jets observed in the polar coronal holes by Hinode's X-Ray Telescope (XRT) during coverage in movies from Solar Dynamic Observatory's Atmospheric Imaging Assembly (AIA) taken in its He II 304 Å band at a cadence of 12 s, we have established a basic characteristic of solar X-ray jets: untwisting motion in the spire. In this presentation, we show the progression of few of these X-ray jets in XRT images and track their untwisting in AIA He II images. From their structure displayed in their XRT movies, 19 jets were evidently standard jets made by interchange reconnection of the magnetic-arcade base with ambient open field, 32 were evidently blowout jets made by blowout eruption of the base arcade, and 3 were of ambiguous form. As was anticipated from the >10,000 km span of the base arcade in most polar X-ray jets and from the disparity of standard jets and blowout jets in their magnetic production, few of the standard X-ray jets (3 of 19) but nearly all of the blowout X-ray jets (29 of 32) carried enough cool (T is approximately 105 K) plasma to be seen in their He II movies. In the 32 X-ray jets that showed a cool component, the He II movies show 10-100 km/s untwisting motions about the axis of the spire in all 3 standard jets and in 26 of the 29 blowout jets. Evidently, the open magnetic field in nearly all blowout X-ray jets and probably in most standard X-ray jets carries transient twist. This twist apparently relaxes by propagating out along the open field as a torsional wave. High-resolution spectrograms and Dopplergrams have shown that most Type-II spicules have torsional motions of 10-30 km/s. Our observation of similar torsional motion in X-ray jets strengthens the case for Type-II spicules being made in the same way as X-ray jets, by blowout eruption of a twisted magnetic arcade in the spicule base and/or by interchange reconnection of the twisted base arcade with the ambient open field. This work was funded by NASA's Heliophysics Division

  5. Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity.

    PubMed

    Kumrungsee, Thanutchaporn; Akiyama, Sayaka; Guo, Jian; Tanaka, Mitsuru; Matsui, Toshiro

    2016-12-15

    Hydrolysis of wheat germ by proteases resulted in bioactive peptides that demonstrated an inhibitory effect against the vasoconstrictive Ca(2+)-calmodulin (CaM)-dependent protein kinase II (CaMK II). The hydrolysate by thermolysin (1.0wt%, 5h) showed a particularly potent CaMK II inhibition. As a result of mixed mode high-performance liquid chromatography of thermolysin hydrolysate with pH elution gradient ranging between 4.8 and 8.9, the fraction eluted at pH 8.9 was the most potent CaMK II inhibitor. From this fraction, Trp-Val and Trp-Ile were identified as CaMK II inhibitors. In Sprague-Dawley rats, an enhanced aortic CaMK II activity by 1μM phenylephrine was significantly (p<0.05) suppressed by 15-min incubation with 300μM Trp-Val or Trp-Ile. On the basis of Ca(2+)-chelating fluorescence and CaMK II activity assays, it was concluded that Trp-Val and Trp-Ile competed with Ca(2+)-CaM complex to bind to CaMK II with Ki values of 5.4 and 3.6μM, respectively.

  6. Antiviral Activity of MK-4965, a Novel Nonnucleoside Reverse Transcriptase Inhibitor▿

    PubMed Central

    Lai, Ming-Tain; Munshi, Vandna; Touch, Sinoeun; Tynebor, Robert M.; Tucker, Thomas J.; McKenna, Philip M.; Williams, Theresa M.; DiStefano, Daniel J.; Hazuda, Daria J.; Miller, Michael D.

    2009-01-01

    Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are the mainstays of therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infections. However, the effectiveness of NNRTIs can be hampered by the development of resistance mutations which confer cross-resistance to drugs in the same class. Extensive efforts have been made to identify new NNRTIs that can suppress the replication of the prevalent NNRTI-resistant viruses. MK-4965 is a novel NNRTI that possesses both diaryl ether and indazole moieties. The compound displays potency at subnanomolar concentrations against wild-type (WT), K103N, and Y181C reverse transcriptase (RT) in biochemical assays. MK-4965 is also highly potent against the WT virus and two most prevalent NNRTI-resistant viruses (viruses that harbor the K103N or the Y181C mutation), against which it had 95% effective concentrations (EC95s) of <30 nM in the presence of 10% fetal bovine serum. The antiviral EC95 of MK-4965 was reduced approximately four- to sixfold when it was tested in 50% human serum. Moreover, MK-4965 was evaluated with a panel of 15 viruses with NNRTI resistance-associated mutations and showed a superior mutant profile to that of efavirenz but not to that of etravirine. MK-4965 was similarly effective against various HIV-1 subtypes and viruses containing nucleoside reverse transcriptase inhibitor or protease inhibitor resistance-conferring mutations. A two-drug combination study showed that the antiviral activity of MK-4965 was nonantagonistic with each of the 18 FDA-licensed drugs tested vice versa in the present study. Taken together, these in vitro data show that MK-4965 possesses the desired properties for further development as a new NNRTI for the treatment of HIV-1 infection. PMID:19289522

  7. Inclusive Jets in PHP

    NASA Astrophysics Data System (ADS)

    Roloff, P.

    Differential inclusive-jet cross sections have been measured in photoproduction for boson virtualities Q^2 < 1 GeV^2 with the ZEUS detector at HERA using an integrated luminosity of 300 pb^-1. Jets were identified in the laboratory frame using the k_T, anti-k_T or SIScone jet algorithms. Cross sections are presented as functions of the jet pseudorapidity, eta(jet), and the jet transverse energy, E_T(jet). Next-to-leading-order QCD calculations give a good description of the measurements, except for jets with low E_T(jet) and high eta(jet). The cross sections have the potential to improve the determination of the PDFs in future QCD fits. Values of alpha_s(M_Z) have been extracted from the measurements based on different jet algorithms. In addition, the energy-scale dependence of the strong coupling was determined.

  8. Measurement of the Top Quark Mass with In Situ Jet Energy Scale Calibration Using Hadronic W Boson Decays at CDF-II

    SciTech Connect

    Arguin, Jean-Francois

    2006-01-01

    We report a measurement of the top quark mass with the upgraded collider detector at Fermilab (CDF-II). The top quarks are produced in pairs (tt) in proton-antiproton collisions with a center-of-mass energy of 1.96 TeV.

  9. Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.

    PubMed

    Ebrahimian, Talin; Li, Melissa Wei; Lemarié, Catherine A; Simeone, Stefania M C; Pagano, Patrick J; Gaestel, Matthias; Paradis, Pierre; Wassmann, Sven; Schiffrin, Ernesto L

    2011-02-01

    Vascular oxidative stress and inflammation play an important role in angiotensin II-induced hypertension, and mitogen-activated protein kinases participate in these processes. We questioned whether mitogen-activated protein kinase-activated protein kinase 2 (MK2), a downstream target of p38 mitogen-activated protein kinase, is involved in angiotensin II-induced vascular responses. In vivo experiments were performed in wild-type and Mk2 knockout mice infused intravenously with angiotensin II. Angiotensin II induced a 30 mm Hg increase in mean blood pressure in wild-type that was delayed in Mk2 knockout mice. Angiotensin II increased superoxide production and vascular cell adhesion molecule-1 in blood vessels of wild-type but not in Mk2 knockout mice. Mk2 knockdown by small interfering RNA in mouse mesenteric vascular smooth muscle cells caused a 42% reduction in MK2 protein and blunted the angiotensin II-induced 40% increase of MK2 expression. Mk2 knockdown blunted angiotensin II-induced doubling of intracellular adhesion molecule-1 expression, 2.4-fold increase of nuclear p65, and 1.4-fold increase in Ets-1. Mk2 knockdown abrogated the angiotensin II-induced 4.7-fold and 1.3-fold increase of monocyte chemoattractant protein-1 mRNA and protein. Angiotensin II enhanced reactive oxygen species levels (by 29%) and nicotinamide adenine dinucleotide phosphate oxidase activity (by 48%), both abolished by Mk2 knockdown. Reduction of MK2 blocked angiotensin II-induced p47phox translocation to the membrane, associated with a 53% enhanced catalase expression. Angiotensin II-induced increase of MK2 was prevented by the nicotinamide adenine dinucleotide phosphate oxidase inhibitor Nox2ds-tat. Mk2 small interfering RNA prevented the angiotensin II-induced 30% increase of proliferation. In conclusion, MK2 plays a critical role in angiotensin II signaling, leading to hypertension, oxidative stress via activation of p47phox and inhibition of antioxidants, and vascular inflammation

  10. Untangling the protostars and jets in HH 900

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan

    2013-02-01

    We propose to obtain high resolution (comparable to HST), narrowband [Fe II] images with GSAOI to disentangle the protostars and jets in HH 900. Recent H-alpha imaging of HH 900 reveals an unusually broad outflow emerging from a small ( 1"), dark globule in Trumpler 16. A bright H-alpha microjet along the western edge of HH 900 may be a second jet-protostar system that was ejected from the dark globule. Strong UV radiation from the many O stars in Trumpler 16 illuminates unshocked material in these jets, making it possible to estimate the jet mass-loss rates and infer the mass accretion history of the driving protostars. Two Spitzer-detected YSOs appear to lie within the globule, although with relatively coarse resolution (2"), Spitzer cannot resolve which protostar drives the jet. However, for HH jets with an associated Spitzer source, we have shown that IR [Fe II] emission traces the jet into the dark globule, connecting the H-alpha jet with the driving protostar. In addition, [Fe II] in these externally irradiated jets is excited in the dense, neutral jet core and may trace most of the mass in the outflow. We also propose to obtain narrowband H_2 images of HH 900 to see if extended H2 emission seen in ground-based images without AO correction corresponds to molecules entrained in the outflow. The associated Spitzer YSOs suggest that HH 900 samples the lower mass end of the jet-driving protostars detectable in Carina. Previous studies of [Fe II] in HH jets in Carina have focused on bright, highly collimated outflows likely driven by more massive, and more evolved protostars. Thus, HH 900 provides an important test of the behavior of lower mass jet driving protostars. These observation will be a chapter in P.I. M. Reiter's PhD thesis.

  11. Corporate Jet

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Gulfstream Aerospace Corporation, Savannah, GA, used a version of a NASA program called WIBCO to design a wing for the Gulfstream IV (G-IV) which will help to reduce transonic drag (created by shock waves that develop as an airplane approaches the speed of sound). The G-IV cruises at 88 percent of the speed of sound, and holds the international record in its class for round-the-world flight. They also used the STANS5 and Profile programs in the design. They will use the NASA program GASP to help determine the gross weight, range, speed, payload and optimum wing area of an intercontinental supersonic business jet being developed in cooperation with Sukhoi Design Bureau, a Soviet organization.

  12. Sex-specific restoration of MK-801-induced sensorimotor gating deficit by environmental enrichment.

    PubMed

    Nozari, M; Shabani, M; Farhangi, A M; Mazhari, S; Atapour, N

    2015-07-23

    Despite ample evidence of N-methyl-D-aspartate (NMDA) receptor dysfunction in schizophrenia, no study has addressed the effects of enriched environment (EE) on sensorimotor gating deficits induced by postnatal NMDA receptor blockade. We evaluated the effect of EE on sensorimotor gating (measured by prepulse inhibition, PPI), or on sensorimotor gating deficit induced by the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) in both sexes of Wistar rats. Rats were injected with MK-801 (1 mg/kg) on postnatal days (P) 6-10. EE was provided from birth up to the time of experiments on P28-30 or P58-60. PPI data were collected at three prepulse intensities and then averaged to yield global PPI. MK-801 treatment reduced PPI significantly in both sexes. While EE per se had no significant effect on PPI, it restored MK-801-induced PPI deficit only in male rats. An extended period of EE did not influence PPI deficit in female rats. Our results indicate that postnatal exposure to MK-801 may exert long-lasting effects on neuronal circuits underlying sensorimotor gating. Sex-specific modulation of such effects by EE suggests sexually dimorphic mechanisms are involved.

  13. A dominant function of CCaMK in intracellular accommodation of bacterial and fungal endosymbionts

    PubMed Central

    Hayashi, Teruyuki; Banba, Mari; Shimoda, Yoshikazu; Kouchi, Hiroshi; Hayashi, Makoto; Imaizumi-Anraku, Haruko

    2010-01-01

    In legumes, Ca2+/calmodulin-dependent protein kinase (CCaMK) is a component of the common symbiosis genes that are required for both root nodule (RN) and arbuscular mycorrhiza (AM) symbioses and is thought to be a decoder of Ca2+ spiking, one of the earliest cellular responses to microbial signals. A gain-of-function mutation of CCaMK has been shown to induce spontaneous nodulation without rhizobia, but the significance of CCaMK activation in bacterial and/or fungal infection processes is not fully understood. Here we show that a gain-of-function CCaMKT265D suppresses loss-of-function mutations of common symbiosis genes required for the generation of Ca2+ spiking, not only for nodule organogenesis but also for successful infection of rhizobia and AM fungi, demonstrating that the common symbiosis genes upstream of Ca2+ spiking are required solely to activate CCaMK. In RN symbiosis, however, CCaMKT265D induced nodule organogenesis, but not rhizobial infection, on Nod factor receptor (NFRs) mutants. We propose a model of symbiotic signaling in host legume plants, in which CCaMK plays a key role in the coordinated induction of infection thread formation and nodule organogenesis. PMID:20409002

  14. asymptoticMK: A Web-Based Tool for the Asymptotic McDonald-Kreitman Test.

    PubMed

    Haller, Benjamin C; Messer, Philipp W

    2017-03-24

    The McDonald-Kreitman (MK) test is a widely used method for quantifying the role of positive selection in molecular evolution. One key shortcoming of this test lies in its sensitivity to the presence of slightly deleterious mutations, which can severely bias its estimates. An asymptotic version of the MK test was recently introduced that addresses this problem by evaluating polymorphism levels for different mutation frequencies separately, and then extrapolating a function fitted to that data. Here we present asymptoticMK, a web-based implementation of this asymptotic McDonald-Kreitman test. Our web service provides a simple R-based interface into which the user can upload the required data (polymorphism and divergence data for the genomic test region and a neutrally evolving reference region). The web service then analyzes the data and provides plots of the test results. This service is free to use, open-source, and available at http://benhaller.com/messerlab/asymptoticMK.html. We provide results from simulations to illustrate the performance and robustness of the asymptoticMK test under a wide range of model parameters.

  15. Cannabidiol Affects MK-801-Induced Changes in the PPI Learned Response of Capuchin Monkeys (Sapajus spp.)

    PubMed Central

    Saletti, Patricia G.; Maior, Rafael S.; Barros, Marilia; Nishijo, Hisao; Tomaz, Carlos

    2017-01-01

    There are several lines of evidence indicating a possible therapeutic action of cannabidiol (CBD) in schizophrenia treatment. Studies with rodents have demonstrated that CBD reverses MK-801 effects in prepulse inhibition (PPI) disruption, which may indicate that CBD acts by improving sensorimotor gating deficits. In the present study, we investigated the effects of CBD on a PPI learned response of capuchin monkeys (Sapajus spp.). A total of seven monkeys were employed in this study. In Experiment 1, we evaluated the CBD (doses of 15, 30, 60 mg/kg, i.p.) effects on PPI. In Experiment 2, the effects of sub-chronic MK-801 (0.02 mg/kg, i.m.) on PPI were challenged by a CBD pre-treatment. No changes in PPI response were observed after CBD-alone administration. However, MK-801 increased the PPI response of our animals. CBD pre-treatment blocked the PPI increase induced by MK-801. Our findings suggest that CBD’s reversal of the MK-801 effects on PPI is unlikely to stem from a direct involvement on sensorimotor mechanisms, but may possibly reflect its anxiolytic properties. PMID:28289391

  16. Comparison of SOHO/UVCS and MLSO MK4 Coronameter Densities

    NASA Technical Reports Server (NTRS)

    Lee, K.-S.; Moon, Y.-J.; Kim, K.-S.; Lee, J.-Y.; Cho, K.-S.; Choe, G. S.

    2008-01-01

    This paper compares the density distributions of the solar corona obtained by UVCS and the Mauna MLSO MK4 coronameter. This is the first attempt to compare the coronal densities estimated by the two instruments. Two UVCS emission lines (O VI 1032 hand 1037.6 A), which have both radiative and collisional components, were used. The coronal number density is determined from the ratio of these two components. The coronal density can be determined by inverting MLSO MK4 polarization maps. It was found that the mean electron number density in a helmet streamer observed by MK4 on 2003 April 28 is fairly consistent with that observed by UVCS. For a coronal hole and an active region observed on 1999 October 19 and 24, the MK4 coronal densities are close to those from the UVCS. The results demonstrate that MK4 polarization data can provide a coronal density distribution in a large field of view with a time cadence of about three minutes.

  17. Properties of Mlso MK3 White-Light CMEs from 1989-1996

    NASA Astrophysics Data System (ADS)

    St Cyr, O. C.; Flint, Q.; Xie, H.; Webb, D. F.; Burkepile, J.; Lecinski, A. R.

    2014-12-01

    Observations low in the solar corona are key to understanding the initiation and propagation of coronal mass ejections (CMEs). Similar to solar magnetographs and total solar irradiance measurements, white-light coronagraph observations are another aspect of Heliophysics that have followed a path comparable to that found in Earth science, where longevity and continuity of measurements lead to new understanding through modeling. Previously we have reported on our efforts to fill the only remaining data gap since 1973 in the CME rate using the Mauna Loa Solar Observatory's MK3 K-coronameter observations from 1989-1996. The MK3 instrument observed routinely several hours most days beginning in 1980 until it was upgraded to MK4 in 1998. MK3 CMEs detected from 1980-1989 were compared with Solwind and SMM and reported by St. Cyr et al. (1999). Here we provide a preliminary report on the statistical properties of CMEs detected during 1989-1996. Since this period began in solar maximum activity conditions and descended into minimum, we can compare the properties of MLSO MK3 events with CMEs detected by other coronagraphs during similar activity phases.

  18. MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma

    PubMed Central

    2011-01-01

    Background Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Results Spinal cord injury in mice resulted in severe trauma characterized by edema, neutrophil infiltration and apoptosis. In this study we clearly demonstrated that administration of MK801 attenuated all inflammatory parameters. In fact 24 hours after injury, the degree of spinal cord inflammation and tissue injury (evaluated as histological score), infiltration of neutrophils, NF-κB activation, iNOS, cytokines levels (TNF-α and IL-1β), neurotrophin expression were markedly reduced by MK801 treatment. Moreover, in a separate set of experiments, we have demonstrated that MK801 treatment significantly improved the recovery of locomotory function. Conclusions Blockade of NMDA by MK801 lends support to the potential importance of NMDA antagonists as therapeutic agents in the treatment of acute spinal cord injury. PMID:21492450

  19. NMDA antagonist MK-801 impairs acquisition of place strategies, but not their use.

    PubMed

    Mackes, Jennifer L; Willner, Jeffrey

    2006-11-25

    Evidence that NMDA receptors contribute to synaptic plasticity in the hippocampus has stimulated research on their role in behavioral learning and memory. Recent studies indicate that NMDA antagonists decrease use of place strategies by rats in a T-maze task that can be solved using either a "place" or "response" strategy. In the present study, rats were given MK-801 before maze exposure and/or training on this redundant strategy T-maze task. MK-801 did not impair rats' ability to learn the task, but did change the strategies they used on a probe trial administered after learning. MK-801 decreased use of place strategies only when administered before both maze exposure and training; rats given MK-801 only before maze exposure or only before training tended to use place strategies on the probe trial. These results show that MK-801 does not prevent rats from utilizing previously acquired spatial information, but does appear to impair the acquisition of spatial information needed for place strategies.

  20. Jet inclusive cross sections

    SciTech Connect

    Del Duca, V.

    1992-11-01

    Minijet production in jet inclusive cross sections at hadron colliders, with large rapidity intervals between the tagged jets, is evaluated by using the BFKL pomeron. We describe the jet inclusive cross section for an arbitrary number of tagged jets, and show that it behaves like a system of coupled pomerons.

  1. Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys

    PubMed Central

    Saletti, Patricia G.; Maior, Rafael S.; Hori, Etsuro; Nishijo, Hisao; Tomaz, Carlos

    2015-01-01

    Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate MK-801 effects on monkeys’ PPI, we tested eight capuchin monkeys (Sapajus spp.) using three different doses of MK-801 (0.01; 0.02; 0.03 mg/kg). Results show PPI impairment in acute administration of the highest dose (0.03 mg/kg). PPI impairment induced by MK-801 was reversed by re-exposure to the PPI test throughout treatment trials, in contrast with rodent studies. These results indicate that tolerance effect and familiarization with PPI test may reduce the sensorimotor gating deficits induced by MK-801 in monkeys, suggesting a drug-training interaction. PMID:26441660

  2. Activation of calcium- and calmodulin-dependent protein kinase (CCaMK), the central regulator of plant root endosymbiosis.

    PubMed

    Singh, Sylvia; Parniske, Martin

    2012-08-01

    The key molecular event during the development of arbuscular mycorrhiza and the root nodule symbiosis is the activation of calcium- and calmodulin-dependent protein kinase (CCaMK). Its regulation is complex and involves positive as well as negative regulation facilitated by autophosphorylation of two conserved sites. Deregulated versions of CCaMK are sufficient for mediating both organogenesis and infection processes. Epistasis tests demonstrated that a main function of signaling components upstream of calcium spiking is the activation of CCaMK. Despite CCaMK being a central signaling hub, specificity for both symbioses exists, resulting in differential transcriptional gene expression patterns. While the specificity upstream of CCaMK can be conceptualized by the specific perception of rhizobial and fungal lipo-chitooligosaccharides via cognate LysM receptors, the mechanisms conferring transcriptional specificity downstream of CCaMK are likely conferred by a variety of transcriptional regulators, mediating symbiosis appropriate gene regulation.

  3. Further measurements of the acoustic performance of a variant of the MK 4 helmet earmuff assembly

    NASA Astrophysics Data System (ADS)

    Cogger, M. K.; Wood, S. A.; Lucas, S. H.

    1981-11-01

    Acoustic tests of the attenuation, frequency response and total harmonic distortion of experimental earmuff assemblies intended as alternatives to the B2 production shells fitted to the Mk 4 flight helmet are reported. The experimental earmuff (melamine shells with flanges) dough molded compound without flanges (Mk 4 alternative assemblies) and B2 production shells (Mk 4 helmet) were tested. Attenuation was calculated from insertion loss, i.e., the difference in db between the unoccluded and occluded spectra. Objective tests, using an artificial ear, and semiobjective tests, using 15 short haired, clean shaven subjects were performed. The A-weighted level of the sound field was 99 db(A), lasting for 15 min, the equivalent of 84 db(A) for 8 hr. The experimental earmuff is superior to the other designs.

  4. Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors.

    PubMed

    Kaptein, Allard; Oubrie, Arthur; de Zwart, Edwin; Hoogenboom, Niels; de Wit, Joeri; van de Kar, Bas; van Hoek, Maaike; Vogel, Gerard; de Kimpe, Vera; Schultz-Fademrecht, Carsten; Borsboom, Judith; van Zeeland, Mario; Versteegh, Judith; Kazemier, Bert; de Roos, Jeroen; Wijnands, Frank; Dulos, John; Jaeger, Martin; Leandro-Garcia, Paula; Barf, Tjeerd

    2011-06-15

    The identification of a potent, selective, and orally available MK2 inhibitor series is described. The initial absence of oral bioavailability was successfully tackled by moving the basic nitrogen of the spiro-4-piperidyl moiety towards the electron-deficient pyrrolepyridinedione core, thereby reducing the pK(a) and improving Caco-2 permeability. The resulting racemic spiro-3-piperidyl analogues were separated by chiral preparative HPLC, and the activity towards MK2 inhibition was shown to reside mostly in the first eluting stereoisomer. This led to the identification of new MK2 inhibitors, such as (S)-23, with low nanomolar biochemical inhibition (EC(50) 7.4 nM) and submicromolar cellular target engagement activity (EC(50) 0.5 μM).

  5. Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

    PubMed

    Denisova, Oxana V; Söderholm, Sandra; Virtanen, Salla; Von Schantz, Carina; Bychkov, Dmitrii; Vashchinkina, Elena; Desloovere, Jens; Tynell, Janne; Ikonen, Niina; Theisen, Linda L; Nyman, Tuula A; Matikainen, Sampsa; Kallioniemi, Olli; Julkunen, Ilkka; Muller, Claude P; Saelens, Xavier; Verkhusha, Vladislav V; Kainov, Denis E

    2014-07-01

    The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that the Akt inhibitor MK2206 blocks influenza pH1N1 virus infection in vitro. In particular, at noncytotoxic concentrations, MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9, and H5N1 viruses, indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.

  6. Heat transfer at a sapphire – indium interface in the 30 mK – 300 mK temperature range

    NASA Astrophysics Data System (ADS)

    Liberadzka, J.; Koettig, T.; Bremer, J.; van der Post, C. C. W.; ter Brake, H. J. M.

    2017-02-01

    Within the framework of the AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) project a direct measurement of the Earth’s gravitational acceleration on antihydrogen will be carried out. In order to obtain satisfactory precision of the measurement, the thermal movement of the particles should be reduced. Therefore a Penning trap, which is used to trap antiprotons and create antihydrogen, will be placed on a mixing chamber of an especially designed dilution refrigerator. The trap consists of 10 electrodes, which need to be electrically insulated, but thermally anchored. To ensure that the trap remains at a temperature below 100 mK, the heat transfer at the metallic-dielectric boundary is investigated. A copper – indium – sapphire – indium – copper sandwich setup was mounted on the CERN Cryolab dilution refrigerator. Keeping the mixing chamber at a constant low temperature in the range of 30 mK to 300 mK, steady-state measurements with indium in normal conducting and superconducting states have been performed. Obtained results along with a precise description of our setup are presented.

  7. Supplemental Reactor Physics Calculations and Analysis of ELF Mk 1A Fuel

    SciTech Connect

    Pope, Michael A.

    2014-10-01

    These calculations supplement previous the reactor physics work evaluating the Enhanced Low Enriched Uranium (LEU) Fuel (ELF) Mk 1A element. This includes various additional comparisons between the current Highly Enriched Uranium (HEU) and LEU along with further characterization of the performance of the ELF fuel. The excess reactivity to be held down at BOC for ELF Mk 1A fuel is estimated to be approximately $2.75 greater than with HEU for a typical cycle. This is a combined effect of the absence of burnable poison in the ELF fuel and the reduced neck shim worth in LEU fuel compared to HEU. Burnable poison rods were conceptualized for use in the small B positions containing Gd2O3 absorber. These were shown to provide $2.37 of negative reactivity at BOC and to burn out in less than half of a cycle. The worth of OSCCs is approximately the same between HEU and ELF Mk 1A (LEU) fuels in the representative loading evaluated. This was evaluated by rotating all banks simultaneously. The safety rod worth is relatively unchanged between HEU and ELF Mk 1A (LEU) fuels in the representative loading evaluated. However, this should be reevaluated with different loadings. Neutron flux, both total and fast (>1 MeV), is either the same or reduced upon changing from HEU to ELF Mk 1A (LEU) fuels in the representative loading evaluated. This is consistent with the well-established trend of lower neutron fluxes for a given power in LEU than HEU.The IPT loop void reactivity is approximately the same or less positive with ELF Mk 1A (LEU) fuel than HEU in the representative loading evaluated.

  8. Attenuation of MK-801-induced behavioral perseveration by typical and atypical antipsychotic pretreatment in rats.

    PubMed

    Tuplin, Erin W; Stocco, Marlaina R; Holahan, Matthew R

    2015-08-01

    The noncompetitive NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5-10-imine maleate (MK-801) has been shown to increase the probability of operant responding during extinction and reduce infralimbic prefrontal cortical activation, possibly modeling the cognitive dysfunction symptomology, and underlying cause, in patients with schizophrenia. The present study sought to determine if typical and/or atypical antipsychotics would attenuate the MK-801-induced behavioral perseveration and whether this would be associated with concomitant changes in phosphorylated ERK1/2 (pERK1/2) labeling in the infralimbic cortex (IL). Male, Long Evans rats were pretreated with the typical antipsychotic, Flupenthixol (0, 0.125, 0.25 or 0.5 mg/kg) or the atypical antipsychotic, aripiprazole (0, 0.3, 1.0, 3.0 mg/kg), then given 0.1 mg/kg MK-801 followed by a 60-min appetitive operant extinction session. Flupenthixol produced a dose-dependent decrease in MK-801-induced bar pressing behavior and locomotor activity and a dose-dependent increase in IL pERK1/2 labeling. Aripiprazole produced a U-shaped dose-response curve on MK-801-induced bar pressing behavior, a dose-dependent decrease in locomotor activity but no changes in IL pERK1/2 labeling. The attenuation of the MK-801-induced behavioral (bar pressing, locomotion) profile by Flupenthixol indicates a clear dopaminergic contribution to this behavior. The behavioral effect of aripiprazole may be due to its a) binding to presynaptic dopamine receptors at the midrange dose decreasing dopamine output and b) binding to postsynaptic dopamine receptors at the higher dose increasing dopamine tone. While both classes of antipsychotics can normalize perseverative behavioral symptoms, the underlying prefrontal cortical dysregulation seems to persist.

  9. Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

    NASA Astrophysics Data System (ADS)

    Trujillo, Keith A.; Akil, Huda

    1991-01-01

    The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is an important mediator of several forms of neural and behavioral plasticity. The present studies examined whether NMDA receptors might be involved in the development of opiate tolerance and dependence, two examples of behavioral plasticity. The noncompetitive NMDA receptor antagonist MK-801 attenuated the development of tolerance to the analgesic effect of morphine without affecting acute morphine analgesia. In addition, MK-801 attenuated the development of morphine dependence as assessed by naloxone-precipitated withdrawal. These results suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.

  10. Calculation of the thermodynamic properties of liquid 3He 4He mixtures for temperatures below 150 mK and 3He concentrations between 0.1 and 8% at zero pressure

    NASA Astrophysics Data System (ADS)

    Kuerten, J. G. M.; Castelijns, C. A. M.; De Waele, A. T. A. M.; Gijsman, H. M.

    1985-02-01

    We performed calculations of thermodynamic quantities of dilute liquid 3He- 4He mixtures, starting from experimental values of the specific heat and the osmotic pressure. The calculations are confined to temperatures below 150 mK and 3He concentrations between 0.1 and 8% at zero pressure. Contrary to previous calculations performed by Radebaugh, our results are in good agreement with the experimental data on both the osmotic pressure and the enthalpy in dilute 3He 4He II mixtures.

  11. Inhibitory effects of KN-93, an inhibitor of Ca2+ calmodulin-dependent protein kinase II, on light-regulated root gravitropism in maize.

    PubMed

    Lu Y-T; Feldman, L J; Hidaka, H

    1993-01-01

    Light is essential for root gravitropism in Zea mays L., cultivar Merit. It is hypothesized that calcium mediates this light-regulated response. KN-93, an inhibitor of calcium/calmodulin kinase II (CaMK II), inhibits light-regulated root gravitropism but does not affect light perception. We hypothesize that CaMK II, or a homologue, operates late in the light/gravity signal transduction chain. Here we provide evidence suggesting a possible physiological involvement of CaMK II in root gravitropism in plants.

  12. Inhibitory effects of KN-93, an inhibitor of Ca2+ calmodulin-dependent protein kinase II, on light-regulated root gravitropism in maize

    NASA Technical Reports Server (NTRS)

    Feldman, L. J.; Hidaka, H.

    1993-01-01

    Light is essential for root gravitropism in Zea mays L., cultivar Merit. It is hypothesized that calcium mediates this light-regulated response. KN-93, an inhibitor of calcium/calmodulin kinase II (CaMK II), inhibits light-regulated root gravitropism but does not affect light perception. We hypothesize that CaMK II, or a homologue, operates late in the light/gravity signal transduction chain. Here we provide evidence suggesting a possible physiological involvement of CaMK II in root gravitropism in plants.

  13. Minifilament Eruption as the Source of a Blowout Jet, C-class Flare, and Type-III Radio Burst

    NASA Astrophysics Data System (ADS)

    Hong, Junchao; Jiang, Yunchun; Yang, Jiayan; Li, Haidong; Xu, Zhe

    2017-01-01

    We report a strong minifilament eruption associated with Geostationary Operational Environmental Satellite C1.6 flare and WIND type-III radio burst. The minifilament, which lies at the periphery of active region 12259, is detected by Hα images from the New Vacuum Solar Telescope. The minifilament undergoes a partial and then a full eruption. Simultaneously, two co-spatial jets are successively observed in extreme ultraviolet images from the Solar Dynamic Observatory. The first jet exhibits a typical fan-spine geometry, suggesting that the co-spatial minifilament is possibly embedded in magnetic fields with a fan-spine structure. However, the second jet displays blowout morphology when the entire minifilament erupts upward, leaving behind a hard X-ray emission source in the base. Differential emission measure analyses show that the eruptive region is heated up to about 4 MK during the fan-spine jet, while up to about 7 MK during the blowout jet. In particular, the blowout jet is accompanied by an interplanetary type-III radio burst observed by WIND/WAVES in the frequency range from above 10 to 0.1 MHz. Hence, the minifilament eruption is correlated with the interplanetary type-III radio burst for the first time. These results not only suggest that coronal jets can result from magnetic reconnection initiated by erupting minifilaments with open fields, but also shed light on the potential influence of minifilament eruption on interplanetary space.

  14. Measured Sensitivity of the First Mark II Phased Array Feed on an ASKAP Antenna

    NASA Astrophysics Data System (ADS)

    Chippendale, A. P.; Brown, A. J.; Beresford, R. J.; Hampson, G. A.; Macleod, A.; Shaw, R. D.; Brothers, M. L.; Cantrall, C.; Forsyth, A. R.; Hay, S. G.; Leach, M.

    2015-09-01

    This paper presents the measured sensitivity of CSIRO's first Mk. II phased array feed (PAF) on an ASKAP antenna. The Mk. II achieves a minimum system-temperature-over-efficiency T_{sys}/η of 78 K at 1.23 GHz and is 95 K or better from 835 MHz to 1.8 GHz. This PAF was designed for the Australian SKA Pathfinder telescope to demonstrate fast astronomical surveys with a wide field of view for the Square Kilometre Array (SKA).

  15. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

    PubMed Central

    Zhao, Yuan-Yuan; Tian, Ying; Zhang, Jing; Xu, Fei; Yang, Yun-Peng; Huang, Yan; Zhao, Hong-Yun; Zhang, Jian-Wei; Xue, Cong; Lam, Michael H; Yan, Li; Hu, Zhi-Huang; Dinglin, Xiao-Xiao; Zhang, Li

    2014-01-01

    Aim Protein kinase B (AKT) signaling frequently is deregulated in human cancers and plays an important role in nasopharyngeal carcinoma (NPC). This preclinical study investigated the effect of MK-2206, a potent allosteric AKT inhibitor, on human NPC cells in vitro and in vivo. Methods The effect of MK-2206 on the growth and proliferation of CNE-1, CNE-2, HONE-1, and SUNE-1 cells was assessed by Cell Counting Kit 8 and colony formation assay. Flow cytometry was performed to analyze cell cycle and apoptosis. The effects of MK-2206 on the AKT pathway were analyzed by Western blotting. Autophagy induction was evaluated via electron microscopy and Western blot. To test the effects of MK-2206 in vivo, CNE-2 cells were subcutaneously implanted into nude mice. Tumor-bearing mice were treated orally with MK-2206 or placebo. Tumors were harvested for immunohistochemical analysis. Results In vitro, MK-2206 inhibited the four NPC cell line growths and reduced the sizes of the colonies in a dose-dependent manner. At 72 and 96 hours, the half maximal inhibitory concentration (IC50) values of MK-2206 in CNE-1, CNE-2, and HONE-1 cell lines were 3–5 μM, whereas in SUNE-1, IC50 was less than 1 μM, and MK-2206 induced cell cycle arrest at the G1 phase. However, our study found no evidence of apoptosis. MK-2206 induced autophagy in NPC cells, as evidenced by electron microscopy and Western blot, and inhibited the growth of tumors that were subcutaneously implanted in mice. Inhibition of downstream phosphorylation through the PRAS40 and S6 pathways seems to be the main mechanism for the MK-2206-induced growth inhibition. Conclusion Our preclinical study suggests that MK-2206’s antiproliferative effect may be useful for NPC treatment; however, strategies for reinforcing this effect are needed to maximize clinical benefit. PMID:25336925

  16. A Coronal Hole Jet Observed with Hinode and the Solar Dynamics Observatory

    NASA Technical Reports Server (NTRS)

    Young, Peter H.; Muglach, Karin

    2014-01-01

    A small blowout jet was observed at the boundary of the south coronal hole on 2011 February 8 at around 21:00 UT. Images from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) revealed an expanding loop rising from one footpoint of a compact, bipolar bright point. Magnetograms from the Helioseismic Magnetic Imager (HMI) on board SDO showed that the jet was triggered by the cancelation of a parasitic positive polarity feature near the negative pole of the bright point. The jet emission was present for 25 mins and it extended 30 Mm from the bright point. Spectra from the EUV Imaging Spectrometer on board Hinode yielded a temperature and density of 1.6 MK and 0.9-1.7 × 10( exp 8) cu cm for the ejected plasma. Line-of-sight velocities reached up to 250 km/s. The density of the bright point was 7.6 × 10(exp 8) cu cm, and the peak of the bright point's emission measure occurred at 1.3 MK, with no plasma above 3 MK.

  17. Understanding jet noise.

    PubMed

    Karabasov, S A

    2010-08-13

    Jets are one of the most fascinating topics in fluid mechanics. For aeronautics, turbulent jet-noise modelling is particularly challenging, not only because of the poor understanding of high Reynolds number turbulence, but also because of the extremely low acoustic efficiency of high-speed jets. Turbulent jet-noise models starting from the classical Lighthill acoustic analogy to state-of-the art models were considered. No attempt was made to present any complete overview of jet-noise theories. Instead, the aim was to emphasize the importance of sound generation and mean-flow propagation effects, as well as their interference, for the understanding and prediction of jet noise.

  18. Combined Experimental and Computational Study on the Unimolecular Decomposition of JP-8 Jet Fuel Surrogates. II: n-Dodecane (n-C12H26).

    PubMed

    Zhao, Long; Yang, Tao; Kaiser, Ralf I; Troy, Tyler P; Ahmed, Musahid; Ribeiro, Joao Marcelo; Belisario-Lara, Daniel; Mebel, Alexander M

    2017-02-16

    We investigated temperature-dependent products in the pyrolysis of helium-seeded n-dodecane, which represents a surrogate of the n-alkane fraction of Jet Propellant-8 (JP-8) aviation fuel. The experiments were performed in a high temperature chemical reactor over a temperature range of 1200 K to 1600 K at a pressure of 600 Torr, with in situ identification of the nascent products in a supersonic molecular beam using single photon vacuum ultraviolet (VUV) photoionization coupled with the analysis of the ions in a reflectron time-of-flight mass spectrometer (ReTOF). For the first time, the initial decomposition products of n-dodecane-including radicals and thermally labile closed-shell species-were probed in experiments, which effectively exclude mass growth processes. A total of 15 different products were identified, such as molecular hydrogen (H2), C2 to C7 1-alkenes [ethylene (C2H4) to 1-heptene (C7H14)], C1-C3 radicals [methyl (CH3), ethyl (C2H5), allyl (C3H5)], small C1-C3 hydrocarbons [acetylene (C2H2), allene (C3H4), methylacetylene (C3H4)], as well as the reaction products [1,3-butadiene (C4H6), 2-butene (C4H8)] attributed to higher-order processes. Electronic structure calculations carried out at the G3(CCSD,MP2)//B3LYP/6-311G(d,p) level of theory combined with RRKM/master equation of rate constants for relevant reaction steps showed that n-dodecane decomposes initially by a nonterminal C-C bond cleavage and producing a mixture of alkyl radicals from ethyl to decyl with approximately equal branching ratios. The alkyl radicals appear to be unstable under the experimental conditions and to rapidly dissociate either directly by C-C bond β-scission to produce ethylene (C2H4) plus a smaller 1-alkyl radical with the number of carbon atoms diminished by two or via 1,5-, 1,6-, or 1,7- 1,4-, 1,9-, or 1,8-H shifts followed by C-C β-scission producing alkenes from propene to 1-nonene together with smaller 1-alkyl radicals. The stability and hence the branching ratios

  19. Development of amorphous solid dispersion formulations of a poorly water-soluble drug, MK-0364.

    PubMed

    Sotthivirat, S; McKelvey, C; Moser, J; Rege, B; Xu, W; Zhang, D

    2013-08-16

    The goal of this study was to demonstrate that MK-0364 solid dispersions can be developed as a means to increase the solubility and bioavailability of a poorly water-soluble drug, MK-0364. The potential solid dispersions would enable an oral solid dosage form as a monotherapy or combination product of MK-0364. Preliminary screening included sample preparation via a solvent casting method, physical characterization, and in vitro dissolution testing. Lead formulations were subsequently manufactured using hot melt extrusion (HME) and spray-drying (SD). All HME (without polyvinyl pyrrolidone) and SD formulations exhibit characteristics of a single phase glass including an amorphous halo when analyzed with X-ray powder diffraction (XRPD), a single glass transition temperature (Tg) measured with differential scanning calorimetry (DSC), and supersaturation when dissolved in dissolution media. The oral absorption of MK-0364 from selected HME and SD formulations in monkeys results in marginally greater exposure with a consistently longer Tmax relative to a liquid filled capsule reference. Based on the processability, physical characterization, in vitro dissolution, and animal pharmacokinetic results, copovidone- and hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based solid dispersion formulations are viable product concepts. The physical stability of both the solid dispersion formulations was also evaluated for 54 weeks under different conditions. The copovidone-based solid dispersion requires protection from moisture.

  20. Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.

    PubMed

    Bungard, Christopher J; Williams, Peter D; Ballard, Jeanine E; Bennett, David J; Beaulieu, Christian; Bahnck-Teets, Carolyn; Carroll, Steve S; Chang, Ronald K; Dubost, David C; Fay, John F; Diamond, Tracy L; Greshock, Thomas J; Hao, Li; Holloway, M Katharine; Felock, Peter J; Gesell, Jennifer J; Su, Hua-Poo; Manikowski, Jesse J; McKay, Daniel J; Miller, Mike; Min, Xu; Molinaro, Carmela; Moradei, Oscar M; Nantermet, Philippe G; Nadeau, Christian; Sanchez, Rosa I; Satyanarayana, Tummanapalli; Shipe, William D; Singh, Sanjay K; Truong, Vouy Linh; Vijayasaradhi, Sivalenka; Wiscount, Catherine M; Vacca, Joseph P; Crane, Sheldon N; McCauley, John A

    2016-07-14

    A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.

  1. Plasma Heating to Super-Hot Temperatures (>30 MK) in the August 9, 2011 Solar Flare

    NASA Astrophysics Data System (ADS)

    Sharykin, Ivan; Struminsky, Alexei; Zimovets, Ivan

    2015-08-01

    We investigate the August 9, 2011 solar flare of X-ray class X6.9, the "hottest" flare from 2000 to 2012, with a peak plasma temperature according to GOES data of 33 MK. Our goal is to determine the cause of such an anomalously high plasma temperature and to investigate the energy balance in the flare region with allowance made for the presence of a super-hot plasma (>30 MK). We analyze the RHESSI, GOES, AIA/SDO, and EVE/SDO data and discuss the spatial structure of the flare region and the results of our spectral analysis of its X-ray emission. Our analysis of the RHESSI X-ray spectra is performed in the one-temperature and two-temperature approximations by taking into account the emission of hot (20 MK) and super-hot (45 MK) plasmas. The hard X-ray spectrum in both models is fitted by power laws. The observed peculiarities of the flare are shown to be better explained in terms of the two-temperature model, in which the super-hot plasma is located at the flare loop tops (or in the magnetic cusp region). The formation of the super-hot plasma can be associated with its heating through primary energy release and with the suppression of thermal conduction.

  2. The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.

    PubMed

    Gekeler, V; Ise, W; Sanders, K H; Ulrich, W R; Beck, J

    1995-03-08

    The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance associated protein MRP compared to their drug sensitive parental counterparts. This and the virtual absence of mdr1/P-glycoprotein gene expression was proven by a complementary DNA polymerase chain reaction (cDNA-PCR) approach. Applying a 72-hour tetrazolium based colorimetric MTT-assay we demonstrate on both MDR sublines a dose-dependent modulation of drug resistances by the leukotriene LTD4 receptor antagonist MK571. A complete reversal of vincristine resistances was achieved at final MK571 concentrations of 30 microM (HL60/AR) or 50 microM (GLC4/ADR) which by itself did not disturb cellular proliferation. The drug resistance of a mdr1/P-gp overexpressing multidrug-resistant HL60 subline, in contrast, was not significantly affected by MK571. Similar effects were seen using the glutathione (GSH) synthesis inhibitor buthionine sulfoximine (BSO). Our results point to a relationship between MRP and a conjugate transporter and identify MK571 as a new tool structure for developing modulators specific for a MRP associated multidrug resistance.

  3. 50 mK cooling solution with an ADR precooled by a sorption cooler

    NASA Astrophysics Data System (ADS)

    Luchier, N.; Duval, J. M.; Duband, L.; Camus, P.; Donnier-Valentin, G.; Linder, M.

    2010-09-01

    CEA/SBT is currently developing a 2.5 K-50 mK cooling solution composed of a small demagnetization refrigerator (ADR) precooled by a sorption cooler, equivalent to the high temperature stage of a two-stage ADR system. Thanks to the use of this dual technology, a low weight cooler able to reach 50 mK with a heat sink up to 2.5 K can be designed. Because the sorption cooler is probably the lightest solution to produce sub-Kelvin temperatures, these developments allow us to propose a solution to face the drastic reduction in the mass budget of space missions like SPICA or IXO. The European Space Agency (ESA) is funding the development of an engineering model able to produce 1 μW net heat lift at 50 mK. It is sized so that the sorption cooler provides an additional 10 μW at 300 mK. The ESA main requirements are an autonomy of more than 24 h and a recycling time smaller than 8 h. We present the design of the system able to meet these requirements as well as the expected performances and preliminary measurements.

  4. Performances of the 50 mK ADR/sorption cooler

    NASA Astrophysics Data System (ADS)

    Luchier, N.; Duval, J. M.; Duband, L.; Tirolien, T.

    2012-04-01

    CEA/SBT is currently testing a 50 mK cooler developed in the framework of a European Space Agency Technological Research Program targeted for the Advanced Telescope for High Energy Astrophysics space mission. This cooler is composed of a small demagnetization refrigerator pre cooled by a sorption cooler stage. This Engineering Model is able to produce 1 μW of net heat lift at 50 mK and an additional 10 μW at 300 mK provided by the sorption cooler stage. The autonomy of the cooler is 24 h, and once the low temperature phase at 50 mK is over, it can be recycled in about 8 h with 10 μW and 100 μW available at respectively the 2.5 and 15 K heat sinks. These performances are in agreement with the European Space Agency requirements. In this paper, we present the detailed thermal performances of the cooler in nominal conditions as well as sensitivity measurements of the variation of the heat sink and the cold end temperatures.

  5. Application of human CFU-Mk assay to predict potential thrombocytotoxicity of drugs.

    PubMed

    Pessina, A; Parent-Massin, D; Albella, B; Van Den Heuvel, R; Casati, S; Croera, C; Malerba, I; Sibiril, Y; Gomez, S; de Smedt, A; Gribaldo, L

    2009-02-01

    Megakaryocytopoiesis gives rise to platelets by proliferation and differentiation of lineage-specific progenitors, identified in vitro as Colony Forming Unit-Megakaryocytes (CFU-Mk). The aim of this study was to refine and optimize the in vitro Standard Operating Procedure (SOP) of the CFU-Mk assay for detecting drug-induced thrombocytopenia and to prevalidate a model for predicting the acute exposure levels that cause maximum tolerated decreases in the platelets count, based on the correlation with the maximal plasma concentrations (C max) in vivo. The assay was linear under the SOP conditions, and the in vitro endpoints (percentage of colonies growing) were reproducible within and across laboratories. The protocol performance phase was carried out testing 10 drugs (selected on the base of their recognised or potential in vivo haematotoxicity, according to the literature). Results showed that a relationship can be established between the maximal concentration in plasma (C max) and the in vitro concentrations that inhibited the 10-50-90 percent of colonies growth (ICs). When C max is lower than IC10, it is possible to predict that the chemicals have no direct toxicity effect on CFU-Mk and could not induce thrombocytopenia due to bone marrow damage. When the C max is higher than IC90 and/or IC50, thrombocytopenia can occur due to direct toxicity of chemicals on CFU-Mk progenitors.

  6. The effects of CA1 5HT4 receptors in MK801-induced amnesia and hyperlocomotion.

    PubMed

    Nasehi, Mohammad; Tabatabaie, Maryam; Khakpai, Fatemeh; Zarrindast, Mohammad-Reza

    2015-02-05

    In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 (62.5 and 625 ng/mouse) and RS23597 (1 and 10 ng/mouse) decreased memory consolidation, but it did not alter head-dip counts, head-dip latency and locomotor activity. Similarly, MK801 (0.5 and 1 μg/mouse) decreased memory consolidation, but had no effect on head-dip counts and head-dip latency. Interestingly, it increased locomotor activity. The results also showed that post-training intra-CA1 injection of a sub-threshold dose of RS67333 (6.25 ng/mouse) or RS23597 (0.1 ng/mouse) could heighten MK801 induced amnesia and decrease locomotor activity, but it did not alter head-dip counts and head-dip latency. In conclusion, our findings suggest that the CA1 5-HT4 receptors are involved in MK801-induced amnesia and hyperlocomotion.

  7. Preliminary Mark-18A (Mk-18A) Target Material Recovery Program Product Acceptance Criteria

    SciTech Connect

    Robinson, Sharon M.; Patton, Bradley D.

    2016-09-01

    The Mk-18A Target Material Recovery Program (MTMRP) was established in 2015 to preserve the unique materials, e.g. 244Pu, in 65 previously irradiated Mk-18A targets for future use. This program utilizes existing capabilities at SRS and Savannah River National Laboratory (SRNL) to process targets, recover materials from them, and to package the recovered materials for shipping to ORNL. It also utilizes existing capabilities at ORNL to receive and store the recovered materials, and to provide any additional processing of the recovered materials or residuals required to prepare them for future beneficial use. The MTMRP is presently preparing for the processing of these valuable targets which is expected to begin in ~2019. As part of the preparations for operations, this report documents the preliminary acceptance criteria for the plutonium and heavy curium materials to be recovered from the Mk-18A targets at SRNL for transport and storage at ORNL. These acceptance criteria were developed based on preliminary concepts developed for processing, transporting, and storing the recovered Mk-18A materials. They will need to be refined as these concepts are developed in more detail.

  8. Effects of MK-886, a leukotriene biosynthesis inhibitor, in a rabbit model of endotoxic shock.

    PubMed

    Can, C; Cinar, M G; Ulker, S; Evinç, A; Koşay, S

    1998-06-05

    Leukotrienes are one of the biological mediators that play a role in endotoxic shock. In this study, we investigated the effects of a leukotriene biosynthesis inhibitor, MK-886, in a rabbit model of endotoxic shock. Lipopolysaccharide (Escherichia coli serotype 055:B5) infusion (1 mg kg(-1) h(-1)) to rabbits caused a biphasic decline in arterial blood pressure and decreased the vasoresponsiveness to phenylephrine, potassium chloride, sodium nitroprusside and acetylcholine in abdominal aortic rings. Oral administration of MK-886 (3-(1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl(-2,2-+ ++dimethylpropanoic acid) (5 mg/kg) 3 h prior to lipopolysaccharide infusion significantly inhibited the decline in arterial blood pressure and enhanced the responsiveness to phenylephrine and acetylcholine, whereas the changes in sodium nitroprusside and potassium chloride responses were not significant. However, the pD2 (-log EC50) values for sodium nitroprusside in this group were higher than those of the group that received lipopolysaccharide alone. Neither the administration of the vehicle alone to endotoxemic rabbits, nor MK-886 administration to control animals, caused significant changes. These data suggest that MK-886 attenuates the hypotension and partially reverses the impaired vascular responsiveness observed in endotoxic shock.

  9. Control of jet noise

    NASA Technical Reports Server (NTRS)

    Schreck, Stefan

    1993-01-01

    This reports describes experiments conducted at the High-Speed Jet Facility at the University of Southern California on supersonic jets. The goal of the study was to develop methods for controlling the noise emitted from supersonic jets by passive and/or active means. Work by Seiner et al (1991) indicates that eddy Mach wave radiation is the dominant noise source in a heated high speed jet. Eddy Mach radiation is caused by turbulent eddies traveling at supersonic speed in the shear layer of the jet. The convection velocity of the eddies decays with increasing distance from the nozzle exit due to the mixing of the jet stream with the ambient fluid. Once the convection speed reaches subsonic velocities, eddy Mach wave radiation ceases. To control noise, a rapid decay of the convection velocity is desired. This may be accomplished by enhanced mixing in the jet. In this study, small aspect ratio rectangular jet nozzles were tested. A flapping mode was noticed in the jets. By amplifying screech components of the jets and destabilizing the jet columns with a collar device, the flapping mode was excited. The result was a rapid decay of the jet velocity. A reduction in eddy Mach radiation in rectangular supersonic jets may be achieved with this device.

  10. DNA Damage activates A Spatially Distinct Late Cytoplasmic Cell Cycle Checkpoint Network Controlled by MK2-mediated RNA Stabilization

    PubMed Central

    Reinhardt, H. Christian; Hasskamp, Pia; Schmedding, Ingolf; Morandell, Sandra; van Vugt, Marcel .A.T.M.; Wang, XiaoZhe; Linding, Rune; Ong, Shao-En; Weaver, David; Carr, Steven A.

    2010-01-01

    Summary Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the p38/MK2 pathway for survival after DNA damage, despite a functional ATR-Chk1 pathway. We used functional genetics to dissect the contributions of Chk1 and MK2 to checkpoint control. We show that nuclear Chk1 activity is essential to establish a G2/M checkpoint, while cytoplasmic MK2 activity is critical for prolonged checkpoint maintenance through a process of post-transcriptional mRNA stabilization. Following DNA damage, the p38/MK2 complex relocalizes from nucleus to cytoplasm where MK2, phosphorylates hnRNPA0, to stabilize Gadd45α mRNA, while p38 phosphorylates and releases the translational inhibitor TIAR. In addition, MK2 phosphorylates PARN, blocking Gadd45α mRNA degradation. Gadd45α functions within a positive feedback loop, sustaining the MK2-dependent cytoplasmic sequestration of Cdc25B/C to block mitotic entry in the presence of unrepaired DNA damage. Our findings demonstrate a critical role for the MK2 pathway in the post-transcriptional regulation of gene expression as part of the DNA damage response in cancer cells. PMID:20932473

  11. Intra-Accumbens Injection of a Dopamine Aptamer Abates MK-801-Induced Cognitive Dysfunction in a Model of Schizophrenia

    PubMed Central

    Holahan, Matthew R.; Madularu, Dan; McConnell, Erin M.; Walsh, Ryan; DeRosa, Maria C.

    2011-01-01

    Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. The present work investigated the ability of a dopamine-binding DNA aptamer to regulate these MK-801-induced cognitive deficits when injected into the nucleus accumbens. Rats were trained to bar press for chocolate pellet rewards then randomly assigned to receive an intra-accumbens injection of a DNA aptamer (200 nM; n = 7), tris buffer (n = 6) or a randomized DNA oligonucleotide (n = 7). Animals were then treated systemically with MK-801 (0.1 mg/kg) and tested for their ability to extinguish their bar pressing response. Two control groups were also included that did not receive MK-801. Data revealed that injection of Tris buffer or the random oligonucleotide sequence into the nucleus accumbens prior to treatment with MK-801 did not reduce the MK-801-induced extinction deficit. Animals continued to press at a high rate over the entire course of the extinction session. Injection of the dopamine aptamer reversed this MK-801-induced elevation in lever pressing to levels as seen in rats not treated with MK-801. Tests for activity showed that the aptamer did not impair locomotor activity. Results demonstrate the in vivo utility of DNA aptamers as tools to investigate neurobiological processes in preclinical animal models of mental health disease. PMID:21779401

  12. 77 FR 24880 - Safety Zone; Jet Express Triathlon, Sandusky Bay, Lake Erie, Lakeside, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Jet Express Triathlon, Sandusky Bay, Lake... intended to restrict vessels from portions of Lake Erie during the Jet Express Triathlon. This proposed... jumping off the ferry boat JET EXPRESS II at the designated position, then swim to the dedicated...

  13. Oxytocin reversed MK-801-induced social interaction and aggression deficits in zebrafish.

    PubMed

    Zimmermann, Fernanda Francine; Gaspary, Karina Vidarte; Siebel, Anna Maria; Bonan, Carla Denise

    2016-09-15

    Changes in social behavior occur in several neuropsychiatric disorders such as schizophrenia and autism. The interaction between individuals is an essential aspect and an adaptive response of several species, among them the zebrafish. Oxytocin is a neuroendocrine hormone associated with social behavior. The aim of the present study was to investigate the effects of MK-801, a non-competitive antagonist of glutamate NMDA receptors, on social interaction and aggression in zebrafish. We also examined the modulation of those effects by oxytocin, the oxytocin receptor agonist carbetocin and the oxytocin receptor antagonist L-368,899. Our results showed that MK-801 induced a decrease in the time spent in the segment closest to the conspecific school and in the time spent in the segment nearest to the mirror image, suggesting an effect on social behavior. The treatment with oxytocin after the exposure to MK-801 was able to reestablish the time spent in the segment closest to the conspecific school, as well as the time spent in the segment nearest to the mirror image. In addition, in support of the role of the oxytocin pathway in modulating those responses, we showed that the oxytocin receptor agonist carbetocin reestablished the social and aggressive behavioral deficits induced by MK-801. However, the oxytocin receptor antagonist L-368,899 was not able to reverse the behavioral changes induced by MK-801. This study supports the critical role for NMDA receptors and the oxytocinergic system in the regulation of social behavior and aggression which may be relevant for the mechanisms associated to autism and schizophrenia.

  14. DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain

    PubMed Central

    Kobayashi, Yuka; Kulikova, Sofya P; Shibato, Junko; Rakwal, Randeep; Satoh, Hiroyuki; Pinault, Didier; Masuo, Yoshinori

    2015-01-01

    AIM: To investigate the impact of MK-801 on gene expression patterns genome wide in rat brain regions. METHODS: Rats were treated with an intraperitoneal injection of MK-801 [0.08 (low-dose) and 0.16 (high-dose) mg/kg] or NaCl (vehicle control). In a first series of experiment, the frontoparietal electrocorticogram was recorded 15 min before and 60 min after injection. In a second series of experiments, the whole brain of each animal was rapidly removed at 40 min post-injection, and different regions were separated: amygdala, cerebral cortex, hippocampus, hypothalamus, midbrain and ventral striatum on ice followed by DNA microarray (4 × 44 K whole rat genome chip) analysis. RESULTS: Spectral analysis revealed that a single systemic injection of MK-801 significantly and selectively augmented the power of baseline gamma frequency (30-80 Hz) oscillations in the frontoparietal electroencephalogram. DNA microarray analysis showed the largest number (up- and down- regulations) of gene expressions in the cerebral cortex (378), midbrain (376), hippocampus (375), ventral striatum (353), amygdala (301), and hypothalamus (201) under low-dose (0.08 mg/kg) of MK-801. Under high-dose (0.16 mg/kg), ventral striatum (811) showed the largest number of gene expression changes. Gene expression changes were functionally categorized to reveal expression of genes and function varies with each brain region. CONCLUSION: Acute MK-801 treatment increases synchrony of baseline gamma oscillations, and causes very early changes in gene expressions in six individual rat brain regions, a first report. PMID:26629322

  15. Plasma heating to super-hot temperatures (>30 MK) in the August 9, 2011 solar flare

    NASA Astrophysics Data System (ADS)

    Sharykin, I. N.; Struminskii, A. B.; Zimovets, I. V.

    2015-01-01

    We investigate the August 9, 2011 solar flare of X-ray class X6.9, the "hottest" flare from 2000 to 2012, with a peak plasma temperature according to GOES data of ≈32.5 MK. Our goal is to determine the cause of such an anomalously high plasma temperature and to investigate the energy balance in the flare region with allowance made for the presence of a super-hot plasma (>30 MK). We analyze the RHESSI, GOES, AIA/SDO, and EVE/SDO data and discuss the spatial structure of the flare region and the results of our spectral analysis of its X-ray emission. Our analysis of the RHESSI X-ray spectra is performed in the one-temperature and two-temperature approximations by taking into account the emission of hot (˜20 MK) and super-hot (˜45 MK) plasmas. The hard X-ray spectrum in both models is fitted by power laws. The observed peculiarities of the flare are shown to be better explained in terms of the two-temperature model, in which the super-hot plasma is located at the flare loop tops (or in the magnetic cusp region). The formation of the super-hot plasma can be associated with its heating through primary energy release and with the suppression of thermal conduction. The anomalously high temperature (33 MK according to GOES) is most likely to be an artefact of the method for calculating the temperature based on two-channel GOES measurements in the one-temperature approximation applied to the emission of a multi-temperature flare plasma with a minor contribution from the low-temperature part of the differential emission measure.

  16. Lorazepam and MK-801 effects on behavioral and electrographic indices of alcohol withdrawal sensitization.

    PubMed

    Veatch, Lynn M; Becker, Howard C

    2005-12-14

    Repeated cycles of chronic ethanol exposure and withdrawal result in sensitization of withdrawal-related CNS hyperexcitability that generally reflects an imbalance in activity of GABA and glutamate systems. Many pharmacological treatments for ethanol withdrawal target neuroadaptive changes in GABA and glutamate neurotransmission. The present study utilized a mouse model of repeated withdrawals to evaluate the ability of lorazepam and MK-801 treatments to antagonize behavioral and electroencephalographic (EEG) measures of sensitized withdrawal seizure activity. Adult male C3H/He mice received chronic intermittent ethanol vapor exposure in inhalation chambers (16 h/day) and during each withdrawal cycle, separate groups of mice were evaluated for handling-induced convulsions (HIC) or abnormal EEG (high-voltage "brief spindle episodes" (BSE)) activity. Lorazepam (0.5-1.0 mg/kg) or MK-801 (0.1-0.3 mg/kg) treatment at 1 h into each of three withdrawal cycles reduced behavioral (HIC) and electrographic (BSE) signs of seizure activity in a dose-related fashion compared to vehicle-treated mice. During a subsequent untreated withdrawal, mice previously treated with lorazepam or MK-801 for earlier withdrawals exhibited reduced HIC activity during the acute phase but exacerbated HIC activity during the protracted phase of this final (fourth) withdrawal cycle. Both lorazepam and MK-801 treatment conditions resulted in enhanced BSE activity during the entire fourth (untreated) withdrawal episode. Collectively, these results suggest that while treatment of repeated ethanol withdrawals with a benzodiazepine (lorazepam) or an NMDA receptor antagonist (MK-801) may have some initial benefits in ameliorating the development of sensitized withdrawal excitability, such treatment may also render subjects more vulnerable to seizure activity at later time points.

  17. Modulation of [3H]MK-801 binding to NMDA receptors in vivo and in vitro.

    PubMed

    Murray, F; Kennedy, J; Hutson, P H; Elliot, J; Huscroft, I; Mohnen, K; Russell, M G; Grimwood, S

    2000-06-02

    [3H]MK-801 binding in vivo was used to determine the occupancy of NMDA receptor ligands shown to allosterically modulate binding in vitro. ED(50) values (mg/kg) were obtained for the channel blockers (+)-5-methyl-10,11-dihydro-5,4-dibenzo[a,d]cyclohepten-5,10-imine maleate ((+)-MK-801, 0.2), 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP, 1.7) and ketamine (4.4). Antagonists at the glutamate (DL-(2-carboxypiperazine-4-yl)propyl-1-phosphonate (DL-CPP, 5.7)) and glycine site (7-Chloro-4-hydroxy-3-(3-phenoxy)-phenyl-2(H)quinolinone (L-701,324, 14.1), 3R(+)cis-4-methyl-pyrrollid-2-one (L-687,414, 15.1)) inhibited [3H]MK-801 binding in vivo to varying maximum levels (69%, 103% and 45%, respectively). NR2B subunit-selective compounds acting at the ifenprodil site inhibited [3H]MK-801 in vivo by a maximum of 52-72% and gave ED(50) values (mg/kg) of: (+/-)-(1S*, 2S*)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol ((+/-)CP-101,606), 1.9; (+/-)-(3R, 4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol ((+/-)CP-283,097), 1.8; (+/-)-(R*, S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol ((+/-)Ro 25-6981), 1.0; ifenprodil, 6.0. The glycine site agonist D-serine stimulated binding to 151% of control with an ED(50) of 1.7 mg/kg. Results show that [3H]MK-801 binding in vivo may be used to measure receptor occupancy of ligands acting not only within the ion channel but also at modulatory sites on the NMDA receptor complex.

  18. Glottal jet inertance

    NASA Astrophysics Data System (ADS)

    Mphail, Michael; Krane, Michael

    2016-11-01

    Estimates of an inertive contribution of the glottal jet to glottal aerodynamic resistance is presented. Given that inertance of the flow in a constriction can be expressed in terms of the kinetic energy of the flow, and that a jet is a maximum kinetic energy flow pattern, it is argued that the glottal jet possesses its own inertance which is at least as large as that of the vocal tract. These arguments are supported by estimates of inertance obtained from simulations of an unsteady flow through an axisymmetric orifice, and of a compliant constriction with the approximate shape and mechanical properties of the vocal folds. It is further shown that the inertive effect of the glottal jet depends on the jet path and jet mixing, with a slowly diffusing, symmetric jet showing higher inertance than an asymmetric jet which rapidly mixes with supraglottal air. Acknowledge support of NIH Grant 2R01DC005642-10A1.

  19. Jets of incipient liquids

    NASA Astrophysics Data System (ADS)

    Reshetnikov, A. V.; Mazheiko, N. A.; Skripov, V. P.

    2000-05-01

    Jets of incipient water escaping into the atmosphere through a short channel are photographed. In some experiments. complete disintegration of the jet is observed. The relationship of this phenomenon with intense volume incipience is considered. The role of the Coanda effect upon complete opening of the jet is revealed. Measurement results of the recoil force R of the jets of incipient liquids are presented. Cases of negative thrust caused by the Coanda effect are noted. Generalization of experimental data is proposed.

  20. Fountain-Jet Turbulence.

    DTIC Science & Technology

    1980-09-01

    and 3 times higher than expected from free- jet results. Hill et al., (Reference 6) in work with foun- tain jets impacting fuselage models, detected ...delineate the origins of the turbulent anomalies associated with fountain jets by extending the previous studies. The results are presented herein...jet velocities were detected with a Thermal Systems Inc. Model 1050 dual-channel constant-temperature anemometer equipped with a Thermal Systems Inc

  1. Study of Jet Transverse Momentum and Jet Rapidity Dependence on Dijet Azimuthal Decorrelations

    SciTech Connect

    Chakravarthula, Kiran

    2012-01-01

    In a collision experiment involving highly energetic particles such as hadrons, processes at high momentum transfers can provide information useful for many studies involving Quantum Chromodynamics (QCD). One way of analyzing these interactions is through angular distributions. In hadron-hadron collisions, the angular distribution between the two leading jets with the largest transverse momentum (pT ) is affected by the production of additional jets. While soft radiation causes small differences in the azimuthal angular distribution of the two leading jets produced in a collision event, additional hard jets produced in the event have more pronounced influence on the distribution of the two leading jets produced in the collision. Thus, the dijet azimuthal angular distribution can serve as a variable that can be used to study the transition from soft to hard QCD processes in a collision event. This dissertation presents a triple-differential study involving the azimuthal angular distribution and the jet transverse momenta, and jet rapidities of the first two leading jets. The data used for this research are obtained from proton-antiproton (p$\\bar{p}$) collisions occurring at a center of mass energy of 1.96TeV, using the DØ detector in Run II of the Tevatron Collider at the Fermi National Accelerator Laboratory (FNAL) in Illinois, USA. Comparisons are made to perturbative QCD (pQCD) predictions at next-to-leading order (NLO).

  2. Impact of Air Injection on Jet Noise

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda; Norum, Tom

    2007-01-01

    The objective of this viewgraph presentation is to review the program to determine impact of core fluidic chevrons on noise produced by dual stream jets (i.e., broadband shock noise - supersonic, and mixing noise - subsonic and supersonic). The presentation reviews the sources of jet noise. It shows designs of Generation II Fluidic Chevrons. The injection impacts shock structure and stream disturbances through enhanced mixing. This may impact constructive interference between acoustic sources. The high fan pressures may inhibit mixing produced by core injectors. A fan stream injection may be required for better noise reduction. In future the modification of Gen II nozzles to allow for some azimuthal control: will allow for higher mass flow rates and will allow for shallower injection angles A Flow field study is scheduled for spring, 2008 The conclusions are that injection can reduce well-defined shock noise and injection reduces mixing noise near peak jet noise angle

  3. Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)

    PubMed Central

    2013-01-01

    Background Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the groups of Houng Ni and Ligou New, and was found to be highly conserved throughout the vertebrates. Studies, both in vivo and in vitro, have shown that it is implicated in tumor suppression as well as tumor promotion, embryogenesis, anxiety, locomotion, cell motility and cell cycle regulation. Methods In order to obtain a molecular model of MK5 that can be used as a working tool for development of chemical probes, three MK5 models were constructed and refined based on three different known crystal structures of the closely related MKs; MK2 [PDB: 2OZA and PDB: 3M2W] and MK3 [PDB: 3FHR]. The main purpose of the present MK5 molecular modeling study was to identify the best suited template for making a MK5 model. The ability of the generated models to effectively discriminate between known inhibitors and decoys was analyzed using receiver operating characteristic (ROC) curves. Results According to the ROC curve analyzes, the refined model based on 3FHR was most effective in discrimination between known inhibitors and decoys. Conclusions The 3FHR-based MK5 model may serve as a working tool for development of chemical probes using computer aided drug design. The biological function of MK5 still remains elusive, but its role as a possible drug target may be elucidated in the near future. PMID:24034446

  4. HST Polarimetry of the 3C 273 Jet

    NASA Astrophysics Data System (ADS)

    Clautice, Devon; Perlman, Eric S.; Sparks, William B.; Biretta, John A.; O'Dea, Christopher P.; Baum, Stefi Alison; Cheung, Chi C.; Birkinshaw, Mark; Worrall, Diana M.; Martel, Andre; Urry, C. Megan; Stawarz, Lukasz; Coppi, Paolo S.; Uchiyama, Yasunobu; Cara, Mihai; Meisenheimer, Klaus; Begelman, Mitchell C.

    2017-01-01

    We present preliminary results using HST polarimetry of the jet of 3C 273. Polarization is a critical parameter for understanding jet flows, and has proven essential in characterizing the physics of FR I jets; high-quality HST polarimetry has been done for just two other FR II jets previously. Our recent work on two quasar jets, where we measured high optical polarization in the brightest X-ray knots, has favored the synchrotron emission model over the alternative IC/CMB model for their optical to X-ray emission. These new observations of 3C 273 allow for the determination of the magnetic field structure and confirmation of which emission mechanisms are operating to create its optical to X-ray emission, and will allow us to greatly advance modeling efforts for this jet and nail down its kinetic power, a key unknown parameter for understanding quasars and their cosmological effects.

  5. Large bouncing jets

    NASA Astrophysics Data System (ADS)

    Cardin, Karl; Weislogel, Mark

    2016-11-01

    We experimentally investigate the phenomena of large jet rebound (bounce), a mode of fluid transfer following oblique jet impacts on hydrophobic surfaces. We initially seek to describe the regimes of such jet bounce in tests conducted in the weightless environment of a drop tower. A parametric study reveals the dependence of the rebound mode on the relevant dimensionless groups such as Weber number We⊥ defined on the velocity component perpendicular to the surface. We show that significantly larger diameter jets behave similarly as much smaller jets demonstrated during previous terrestrial investigations when We⊥ 1 . For We⊥ > 1 , large jet impacts create fishbone-like structures. We also explore rebounds from nonplanar substrates. Improving our understanding of such jet rebound opens avenues for unique transport capabilities. NASA Cooperative Agreement NNX12A047A.

  6. Hydroacoustic pulsating jet generator

    NASA Astrophysics Data System (ADS)

    Unrau, A.; Meier, G. E. A.

    1987-04-01

    A high pressure turbulent jet generator connected to a low pressure hydraulic tube is studied to investigate water hammer in tubes with fast flow variations, generating high pressure pulsating water jets. The pulsating jet generator consists of a tube, a hydraulic valve, a spring, and a water container. The jet is the effect of the combination of turbulent pipe flow with a valve for flow nozzle. The jet pressure depends on specific oscillation impedance and flow velocity variations. For inlet pressure of 0.5 to 2 bar the pressure rises to 40 bar. The described pulsating jet generator is more effective than the earlier model. A piezoelectric pressure controller is used to register pressure signals and high speed photos are made of the jet. Test results are consistent with theoretical calculation.

  7. Evaluation of the ocean technology system's MK 1-S wireless surface unit, MK 1 DCI two diver air radio, MK 1-D-A wireless diver unit, MK 1-D-H hardwire diver unit and MK 1-D/S unit

    NASA Astrophysics Data System (ADS)

    Reyle, B. E.

    1985-05-01

    The OTS was evaluated for intelligibility, reliability and human engineering. The test subjects possessed various levels of experience with wireless or hardwire communication and SCUBA. The conditions under which the equipment was tested varied. Surface air temperatures ranged from 37 to 85 F; water temperatures from 65 to 80 F; and water depths from 8 feet of seawater (FSW) to greater than 60 FSW. The tests were conducted inside a circular 30 foot deep ascent tower, in shallow open bay water, and finally in an open ocean environment. The equipment was evaluated in areas of both high and low noise levels on the surface as well as in water. The OTS produced an overall intelligibility of 89.24% during manned open water testing using the Modified Rhyme Test (MRT) as the evaluation criteria, with a minimum effective range of 330 yards at 12 FSW and at least 875 yards, although it appears that the range of the MK 1-D-A is somewhat greater. Human engineering aspects of the OTS were found to be more than satisfactory, with no material failures encountered during testing. It is interesting to note that whenever the equipment required minor adjustments, these could be effected by the diver in the water (on the surface) and in most cases in less than 5 minutes. The amount of maintenance required on the OTS was minimal.

  8. An increase or a decrease in myosin II phosphorylation inhibits macrophage motility

    PubMed Central

    1991-01-01

    Myosin II purified from mammalian non-muscle cells is phosphorylated on the 20-kD light chain subunit (MLC20) by the Ca2+/calmodulin-dependent enzyme myosin light chain kinase (MLCK). The importance of MLC20 phosphorylation in regulating cell motility was investigated by introducing either antibodies to MLCK (MK-Ab) or a Ca2+/calmodulin- independent, constitutively active form of MLCK (MK-) into macrophages. The effects of these proteins on cell motility were then determined using a quantitative chemotaxis assay. Chemotaxis is significantly diminished in macrophages containing MK-Ab compared to macrophages containing control antibodies. Moreover, there is an inverse relationship between the number of cells that migrate and the amount of MK-Ab introduced into cells. Interestingly, there is also an inverse relationship between the number of cells that migrate and the amount of MK- introduced into cells. Other experiments demonstrated that MK-Ab decreased intracellular MLC20 phosphorylation while MK- increased MLC20 phosphorylation. MK- also increased the amount of myosin associated with the cytoskeleton. These data demonstrate that the regulation of MLCK is an important aspect of cell motility and suggest that MLC20 phosphorylation must be maintained within narrow limits during translational motility by mammalian cells. PMID:2071674

  9. Z boson production in association with heavy quark jets at D0

    SciTech Connect

    Joseph Anthony Zennamo, III

    2013-10-28

    The dominant background in searches for a Higgs boson decaying into b-quarks at the Tevatron is production of a Z boson in association with either b- or c-quark initiated jets (b or c jets). This thesis describes the first measurements of the ratio of differential cross sections σ (Z + b jet)/ σ(Z + jet), and the first measurements of the ratio of cross sections σ (Z + c jet)/ σ(Z + jet) and σ (Z + c jet)/ σ(Z + b jet). These measurements are performed using the full D0 Run II data set corresponding to an integrated luminosity of 9.7 fb-1. The ratio of differential cross sections σ(Z + b jet)/σ (Z + jet) have been measured as a function of jet and Z boson pT , jet η , and Δφ(Z, jet). The Z+c jet ratios of differential cross sections are measured as a function of jet and Z boson pT .

  10. MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

    PubMed Central

    Xu, Lei; Yates, Cecelia C.; Lockyer, Pamela; Xie, Liang; Bevilacqua, Ariana; He, Jun; Lander, Cynthia; Patterson, Cam; Willis, Monte

    2014-01-01

    The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and development of adhesions in conjunction with abdominal surgery. MK2 is critical to the pathogenesis of ischemic heart injury as MK2 −/− mice are resistant to ischemic remodeling. Therefore, we tested the hypothesis that inhibiting MK2 with MMI-0100 would protect the heart after acute myocardial infarction (AMI) in vivo. AMI was induced by placing a permanent LAD coronary ligation. When MMI-0100 peptide was given 30 minutes after permanent LAD coronary artery ligation, the resulting fibrosis was reduced/prevented ~50% at a 2 week time point, with a corresponding improvement in cardiac function and decrease in left ventricular dilation. In cultured cardiomyocytes and fibroblasts, MMI-0100 inhibited MK2 to reduce cardiomyocyte caspase 3/7 activity, while enhancing primary cardiac fibroblast caspase 3/7 activity, which may explain MMI-0100’s salvage of cardiac function and anti-fibrotic effects in vivo. These findings suggest that therapeutic inhibition of MK2 after acute MI, using rationally-designed cell-permeant peptides, inhibits cardiac fibrosis and maintains cardiac function by mechanisms that involve inhibiting cardiomyocyte apoptosis, while enhancing primary cardiac fibroblast cell death. PMID:25257914

  11. Relation between Spinning Conditions and Jet Profile in Electrospinning

    NASA Astrophysics Data System (ADS)

    Kadomae, Yosuke; Sugimoto, Masataka; Taniguchi, Takashi; Koyama, Kiyohito

    Relationship between electrospun fibers and spinning conditions are investigated from the view point of jet profiles such as diameter distribution, jet velocity, and the evaporation rate of solvent from the surface of jet in solution electrospinning process by changing (i) the applied voltage and (ii) the relative humidity of ambient air. Profiles of jets near the droplet at the tip of needle are measured as functions of the position along the spinning line by using photographs. The measured profiles of jet can be fitted nicely by the analytic expression of spinning profile for a non-evaporating Newtonian fluid, which enables us to calculate the velocity profile of jets and the evaporation rate of solvent from the jet as a function of the position along the spinning line. Changing the applied voltage, it is found that the jet velocity and the evaporation rate in our measured region are decreased and beaded fibers are increased when increasing the applied voltage, on the other hand the total amount of evaporated solvent from a jet in our measured region is too small to affect the profile of jet and to change the viscosity of solution in the jet. Changing the relative humidity, it is found that profiles of jets are almost the same except for the evaporation rate. The evaporation rate in our measured region is increased by decreasing the relative humidity. In the lower humidity region, less than 60% of humidity, beaded fibers are hardly formed, but in the higher humidity region, more than 60%, beaded fibers are increased with increasing humidity. From the results in two conditions (i) and (ii), it is found that the beaded fibers are easily formed as the evaporation rate of solvent becomes smaller.

  12. Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors.

    PubMed

    Pessôa, Renata Fittipaldi; Castro, Newton Gonçalves; Noël, François

    2005-05-15

    Several studies have suggested that l-glutamate is a putative neurotransmitter in Schistosoma mansoni. Recently, we detected the presence of low-affinity binding sites for [(3)H]kainic acid in the heterogeneous (P(1)) subcellular fraction of S. mansoni. In an attempt to characterize N-methyl-d-aspartate (NMDA) receptors in this worm, we performed binding assays with [(3)H]MK-801, a NMDA non-competitive antagonist, in the P(1) fraction of adult S. mansoni. In competition experiments, MK-801 (IC(50) approximately 200 microM) and ketamine (IC(50) approximately 500 microM) exhibited a low affinity for the sites labeled with [(3)H]MK-801. Along with the lack of modulation of this binding by glutamatergic agonists and antagonists and the absence of stereoselectivity for MK-801 isomers, these results suggest that [(3)H]MK-801 could label a site different from the classical NMDA receptor in S. mansoni. Based on the evidences that MK-801 interacts with mammalian muscle and central nervous system nicotinic receptors as a low-affinity noncompetitive antagonist, we have investigated the effects of MK-801 on the nicotine-induced flaccid paralysis of the worm, in vivo. The motility of S. mansoni was quantified by image analysis through a measure of displacement of the worm's extremities. In the presence of (-)-nicotine (10-100 microM), we observed an immediate paralysis of the worms, that was inhibited by 1mM MK-801. Besides nicotine, choline (10-50mM) was also able to inhibit the worm's motility. As a conclusion, we suggest that [(3)H]MK-801 binds to nicotinic receptors, and not NMDA receptors, in subcellular fractions of S. mansoni.

  13. Primary thermometry triad at 6 mK in mesoscopic circuits

    NASA Astrophysics Data System (ADS)

    Iftikhar, Z.; Anthore, A.; Jezouin, S.; Parmentier, F. D.; Jin, Y.; Cavanna, A.; Ouerghi, A.; Gennser, U.; Pierre, F.

    2016-09-01

    Quantum physics emerge and develop as temperature is reduced. Although mesoscopic electrical circuits constitute an outstanding platform to explore quantum behaviour, the challenge in cooling the electrons impedes their potential. The strong coupling of such micrometre-scale devices with the measurement lines, combined with the weak coupling to the substrate, makes them extremely difficult to thermalize below 10 mK and imposes in situ thermometers. Here we demonstrate electronic quantum transport at 6 mK in micrometre-scale mesoscopic circuits. The thermometry methods are established by the comparison of three in situ primary thermometers, each involving a different underlying physics. The employed combination of quantum shot noise, quantum back action of a resistive circuit and conductance oscillations of a single-electron transistor covers a remarkably broad spectrum of mesoscopic phenomena. The experiment, performed in vacuum using a standard cryogen-free dilution refrigerator, paves the way towards the sub-millikelvin range with additional thermalization and refrigeration techniques.

  14. Monitoring Excitations of the N =1 Landau Level by Optical Emission at mK Temperatures

    NASA Astrophysics Data System (ADS)

    Levy, Antonio; Wurstbauer, Ursula; Fields, Dov; Pinczuk, Aron; Watson, John; Mondal, Sumit; Manfra, Michael J.; West, Ken W.; Pfeiffer, Loren N.

    2013-03-01

    Optical emission experiments have proven to be powerful contactless probe of collective states of electrons in the second (N =1) Landau Level (LL). We report the emission spectrum from optical recombination in the N =0 and N =1 LL's the second LL. The 2DEG is confined in ultra-high-mobility GaAs quantum well structures. Optical emission red-shifted from the main luminescence of the N =0 and N =1 LL are interpreted as shakeup processes of quasiparticles in the N =1 LL. Results of two samples with different carrier densities measured in the temperature range of 42mK <=T <=650mK will be compared. The experimental observations will be discussed taking into account the striking quantum phases dominating the second LL. Supported by NSF and AvH

  15. Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity

    PubMed Central

    Okuyama, Satoshi; Miyazaki, Kohei; Yamada, Rie; Amakura, Yoshiaki; Yoshimura, Morio; Sawamoto, Atsushi; Nakajima, Mitsunari; Furukawa, Yoshiko

    2017-01-01

    Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3′,4′-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately detected in the brain and that the permeability of the brain tissues to it was significantly higher than that of other citrus PMFs (nobiletin, tangeretin, and natsudaidain). The permeation of these PMFs into the brain well correlated with their abilities to suppress MK-801-induced locomotive hyperactivity, suggesting that HMF had the ability to act directly in the brain. We also obtained data suggesting that the suppressive effect of HMF on MK-801-induced locomotive hyperactivity was mediated by phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in the hippocampus. PMID:28245567

  16. Measurement of an explosive behavior in the mouse, induced by MK-801, a PCP analogue.

    PubMed

    Deutsch, S I; Hitri, A

    1993-06-01

    MK-801, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor complex that binds with high-affinity to the phencyclidine (PCP) binding site, stimulated an outbred strain of NIH Swiss mice to display discrete episodes of explosive jumping behavior, designated as "popping." The episodes of this behavior were characterized with respect to their dose dependency, latency, and duration. The number of mice displaying this behavior increased with increasing doses of MK-801. The intensity of the popping behavior was sensitive to dose-dependent inhibition by haloperidol, a conventional antipsychotic medication, and clozapine, an atypical antipsychotic medication. In view of PCP's ability to precipitate a schizophreniform psychosis in humans, the behavior may serve as a useful preclinical paradigm for the screening of potentially novel antipsychotic medications.

  17. Pulmonary Oxygen Toxicity with Exercise: Single MK 25 Rebreather Dives or Split 6-Hour Exposures

    DTIC Science & Technology

    2007-10-01

    blood samples were taken and hemoglobin and carboxyhemoglobin concentrations measured (CO- oximeter, Instrumentation Laboratory; Lexington, MA) for...performance was measured in conjunction with the dives. Two sets of similar dives using the MK 20 UBA were then conducted with three days off between...sets. Physical performance and total plasma antioxidant potential were measured . After the single dives, the incidence of respiratory symptoms (23%) or

  18. Six Degree of Freedom Flight Dynamic Model of a MK-82 Store

    DTIC Science & Technology

    1994-01-01

    were calculated in subroutine AERO2 , which retrieves the appropriate aerodynamic coefficients from the wind tunnel database using database access...23 * . * *! *1 2;3 • 0 6, Appendix B - Additional Subroutines Developed for Mk-82 ( - Simulation -. Subroutine AERO2 The AEitO2 subroutine is...is called front AERO2 and has angle of attack and sideslip as its inputs. The outputs are the Euler angles Theta and Phi, with Psi being set at zero

  19. Lessons Learned from Outsourcing the Pearl Harbor MK-48 Intermediate Maintenance Activity

    DTIC Science & Technology

    2008-03-01

    this case study is to evaluate this effort and to show the applicability of market-based tools in the public sector, and especially by the Department... study was to conduct a qualitative and quantitative evaluation of the model used to outsource the Intermediate Maintenance Activity (IMA) for the MK-48...torpedo, which is currently performed at in Pearl Harbor (Hawaii) by Raytheon Company. This research is oriented as a case study analysis for public

  20. Injection of MK-801 affects ocular dominance shifts more than visual activity.

    PubMed

    Daw, N W; Gordon, B; Fox, K D; Flavin, H J; Kirsch, J D; Beaver, C J; Ji, Q; Reid, S N; Czepita, D

    1999-01-01

    Kittens were given intramuscular injections of the N-methyl--aspartate (NMDA) antagonist MK-801 twice daily (morning and midday) during the peak of the period of susceptibility for ocular dominance changes. They were then exposed to light with one eye closed for 4 h after each injection. The ocular dominance of these kittens was shifted significantly less than that of kittens injected with saline and exposed to light over the same period at the same age. After recording a sample of cells for an ocular dominance histogram, the kittens were injected with the same dose of MK-801 that was used during rearing to observe its effect on the activity of single cells in the visual cortex. In the majority of cells (7/13) there was no significant change in activity. Positive evidence for a reduction in activity was seen in only a minority (3/13) of cells. In a separate series of experiments, dose-response curves were measured for cells in the visual cortex in response to iontophoresis of NMDA or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and the effect of an injection of MK-801 on these curves was measured. MK-801, at doses similar to those used in the ocular dominance experiments, had a significant effect on the dose-response curves for NMDA, but little effect on the dose-response curves for AMPA, or the visual responses of the cells. We conclude that ocular dominance shifts can be reduced significantly by a treatment that has little effect on the level of activity of cells in the visual cortex but does specifically affect the responses of the cells to NMDA as opposed to the responses to AMPA.

  1. Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets

    PubMed Central

    Yang, Xiao-Lei; Ge, Meng-Kai; Mao, De-Kui; Lv, Ying-Tao; Sun, Shu-Yan; Yu, Ai-Ping

    2016-01-01

    Objectives. After development and differentiation, megakaryocytes (MKs) can produce platelets. As is well known, thrombopoietin (TPO) can induce MKs to differentiate. The effect of thrombin on MKs differentiation is not clear. In this study, we used a human megakaryoblastic leukemia cell line (Meg-01) to assess the effect of thrombin on MKs differentiation. Methods. In order to interrogate the role of thrombin in Meg-01 cells differentiation, the changes of morphology, cellular function, and expression of diverse factors were analyzed. Results. The results show that thrombin suppresses Meg-01 cells proliferation and induces apoptosis and cell cycle arrest. Thrombin upregulates the expression of CD41b, which is one of the most important MK markers. Globin transcription factor 1 (GATA-1), an important transcriptional regulator, controls MK development and maturation. The expression of GATA-1 is also upregulated by thrombin in Meg-01 cells. The expression of B-cell lymphoma 2 (Bcl-2), an apoptosis-inhibitory protein, is downregulated by thrombin. Phosphorylated protein kinase B (p-AKT) and phosphorylated extracellular signal-regulated kinase (p-ERK) were upregulated by thrombin in Meg-01 cells. All the results are consistent with Meg-01 cells treated with TPO. Discussion and Conclusion. In conclusion, all these data indicate that thrombin maybe plays an important role in MK differentiation into platelets. However, whether the platelet-like particles are certainly platelets remains unknown. PMID:27064425

  2. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity.

    PubMed

    Thomas, David M; Kuhn, Donald M

    2005-07-19

    Methamphetamine causes long-term toxicity to dopamine nerve endings of the striatum. Evidence is emerging that microglia can contribute to the neuronal damage associated with disease, injury, or inflammation, but their role in methamphetamine-induced neurotoxicity has received relatively little attention. Lipopolysaccharide (LPS) and the neurotoxic HIV Tat protein, which cause dopamine neuronal toxicity after direct infusion into brain, cause activation of cultured mouse microglial cells as evidenced by increased expression of intracellular cyclooxygenase-2 and elevated secretion of tumor necrosis factor-alpha. MK-801, a non-competitive NMDA receptor antagonist that is known to protect against methamphetamine neurotoxicity, prevents microglial activation by LPS and HIV Tat. Dextromethorphan, an antitussive agent with NMDA receptor blocking properties, also prevents microglial activation. In vivo, MK-801 and dextromethorphan reduce methamphetamine-induced activation of microglia in striatum and they protect dopamine nerve endings against drug-induced nerve terminal damage. The present results indicate that the ability of MK-801 and dextromethorphan to protect against methamphetamine neurotoxicity is related to their common property as blockers of microglial activation.

  3. A 30 mK, 13.5 T scanning tunneling microscope with two independent tips

    SciTech Connect

    Roychowdhury, Anita; Gubrud, M. A.; Dana, R.; Dreyer, M.; Anderson, J. R.; Lobb, C. J.; Wellstood, F. C.

    2014-04-15

    We describe the design, construction, and performance of an ultra-low temperature, high-field scanning tunneling microscope (STM) with two independent tips. The STM is mounted on a dilution refrigerator and operates at a base temperature of 30 mK with magnetic fields of up to 13.5 T. We focus on the design of the two-tip STM head, as well as the sample transfer mechanism, which allows in situ transfer from an ultra high vacuum preparation chamber while the STM is at 1.5 K. Other design details such as the vibration isolation and rf-filtered wiring are also described. Their effectiveness is demonstrated via spectral current noise characteristics and the root mean square roughness of atomic resolution images. The high-field capability is shown by the magnetic field dependence of the superconducting gap of Cu{sub x}Bi{sub 2}Se{sub 3}. Finally, we present images and spectroscopy taken with superconducting Nb tips with the refrigerator at 35 mK that indicate that the effective temperature of our tips/sample is approximately 184 mK, corresponding to an energy resolution of 16 μeV.

  4. A 30 mK, 13.5 T scanning tunneling microscope with two independent tips

    NASA Astrophysics Data System (ADS)

    Roychowdhury, Anita; Gubrud, M. A.; Dana, R.; Anderson, J. R.; Lobb, C. J.; Wellstood, F. C.; Dreyer, M.

    2014-04-01

    We describe the design, construction, and performance of an ultra-low temperature, high-field scanning tunneling microscope (STM) with two independent tips. The STM is mounted on a dilution refrigerator and operates at a base temperature of 30 mK with magnetic fields of up to 13.5 T. We focus on the design of the two-tip STM head, as well as the sample transfer mechanism, which allows in situ transfer from an ultra high vacuum preparation chamber while the STM is at 1.5 K. Other design details such as the vibration isolation and rf-filtered wiring are also described. Their effectiveness is demonstrated via spectral current noise characteristics and the root mean square roughness of atomic resolution images. The high-field capability is shown by the magnetic field dependence of the superconducting gap of CuxBi2Se3. Finally, we present images and spectroscopy taken with superconducting Nb tips with the refrigerator at 35 mK that indicate that the effective temperature of our tips/sample is approximately 184 mK, corresponding to an energy resolution of 16 μeV.

  5. A 30 mK, 13.5 T scanning tunneling microscope with two independent tips.

    PubMed

    Roychowdhury, Anita; Gubrud, M A; Dana, R; Anderson, J R; Lobb, C J; Wellstood, F C; Dreyer, M

    2014-04-01

    We describe the design, construction, and performance of an ultra-low temperature, high-field scanning tunneling microscope (STM) with two independent tips. The STM is mounted on a dilution refrigerator and operates at a base temperature of 30 mK with magnetic fields of up to 13.5 T. We focus on the design of the two-tip STM head, as well as the sample transfer mechanism, which allows in situ transfer from an ultra high vacuum preparation chamber while the STM is at 1.5 K. Other design details such as the vibration isolation and rf-filtered wiring are also described. Their effectiveness is demonstrated via spectral current noise characteristics and the root mean square roughness of atomic resolution images. The high-field capability is shown by the magnetic field dependence of the superconducting gap of CuxBi2Se3. Finally, we present images and spectroscopy taken with superconducting Nb tips with the refrigerator at 35 mK that indicate that the effective temperature of our tips/sample is approximately 184 mK, corresponding to an energy resolution of 16 μeV.

  6. An expert computer program for classifying stars on the MK spectral classification system

    SciTech Connect

    Gray, R. O.; Corbally, C. J.

    2014-04-01

    This paper describes an expert computer program (MKCLASS) designed to classify stellar spectra on the MK Spectral Classification system in a way similar to humans—by direct comparison with the MK classification standards. Like an expert human classifier, the program first comes up with a rough spectral type, and then refines that spectral type by direct comparison with MK standards drawn from a standards library. A number of spectral peculiarities, including barium stars, Ap and Am stars, λ Bootis stars, carbon-rich giants, etc., can be detected and classified by the program. The program also evaluates the quality of the delivered spectral type. The program currently is capable of classifying spectra in the violet-green region in either the rectified or flux-calibrated format, although the accuracy of the flux calibration is not important. We report on tests of MKCLASS on spectra classified by human classifiers; those tests suggest that over the entire HR diagram, MKCLASS will classify in the temperature dimension with a precision of 0.6 spectral subclass, and in the luminosity dimension with a precision of about one half of a luminosity class. These results compare well with human classifiers.

  7. Hydrodynamics of pulsed jetting in juvenile and adult brief squid Lolliguncula brevis: evidence of multiple jet 'modes' and their implications for propulsive efficiency.

    PubMed

    Bartol, Ian K; Krueger, Paul S; Stewart, William J; Thompson, Joseph T

    2009-06-01

    The dynamics of pulsed jetting in squids throughout ontogeny is not well understood, especially with regard to the development of vortex rings, which are common features of mechanically generated jet pulses (also known as starting jets). Studies of mechanically generated starting jets have revealed a limiting principle for vortex ring formation characterized in terms of a ;formation number' (F), which delineates the transition between the formation of isolated vortex rings and vortex rings that have; pinched off' from the generating jet. Near F, there exists an optimum in pulse-averaged thrust with (potentially) low energetic cost, raising the question: do squids produce vortex rings and if so, do they fall near F, where propulsive benefits presumably occur? To better understand vortex ring dynamics and propulsive jet efficiency throughout ontogeny, brief squid Lolliguncula brevis ranging from 3.3 to 9.1 cm dorsal mantle length (DML) and swimming at speeds of 2.43-22.2 cms(-1) (0.54-3.50 DMLs(-1)) were studied using digital particle image velocimetry (DPIV). A range of jet structures were observed but most structures could be classified as variations of two principal jet modes: (1) jet mode I, where the ejected fluid rolled up into an isolated vortex ring; and (2) jet mode II, where the ejected fluid developed into a leading vortex ring that separated or ;pinched off' from a long trailing jet. The ratio of jet length [based on the vorticity extent (L(omega))] to jet diameter [based on peak vorticity locations (D(omega))] was <3.0 for jet mode I and >3.0 for jet mode II, placing the transition between modes in rough agreement with F determined in mechanical jet studies. Jet mode II produced greater time-averaged thrust and lift forces and was the jet mode most heavily used whereas jet mode I had higher propulsive efficiency, lower slip, shorter jet periods and a higher frequency of fin activity associated with it. No relationship between L(omega)/D(omega) and speed

  8. Search for WW and WZ production in lepton, neutrino plus jets final states at CDF Run II and Silicon module production and detector control system for the ATLAS SemiConductor Tracker

    SciTech Connect

    Sfyrla, Anna

    2008-03-10

    In the first part of this work, we present a search for WW and WZ production in charged lepton, neutrino plus jets final states produced in p$\\bar{p}$ collisions with √s = 1.96 TeV at the Fermilab Tevatron, using 1.2 fb-1 of data accumulated with the CDF II detector. This channel is yet to be observed in hadron colliders due to the large singleWplus jets background. However, this decay mode has a much larger branching fraction than the cleaner fully leptonic mode making it more sensitive to anomalous triple gauge couplings that manifest themselves at higher transverse W momentum. Because the final state is topologically similar to associated production of a Higgs boson with a W, the techniques developed in this analysis are also applicable in that search. An Artificial Neural Network has been used for the event selection optimization. The theoretical prediction for the cross section is σWW/WZtheory x Br(W → ℓv; W/Z → jj) = 2.09 ± 0.14 pb. They measured NSignal = 410 ± 212(stat) ± 102(sys) signal events that correspond to a cross section σWW/WZ x Br(W → ℓv; W/Z → jj) = 1.47 ± 0.77(stat) ± 0.38(sys) pb. The 95% CL upper limit to the cross section is estimated to be σ x Br(W → ℓv; W/Z → jj) < 2.88 pb. The second part of the present work is technical and concerns the ATLAS SemiConductor Tracker (SCT) assembly phase. Although technical, the work in the SCT assembly phase is of prime importance for the good performance of the detector during data taking. The production at the University of Geneva of approximately one third of the silicon microstrip end-cap modules is presented. This collaborative effort of the university of Geneva group that lasted two years, resulted in 655 produced modules, 97% of which were good modules, constructed within the mechanical and electrical specifications and delivered in the SCT collaboration for assembly on the end-cap disks. The SCT end-caps and barrels

  9. DAG/PKCδ and IP3/Ca²⁺/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway.

    PubMed

    Dai, Lianzhi; Zhuang, Luhua; Zhang, Bingchang; Wang, Fen; Chen, Xiaolei; Xia, Chun; Zhang, Bing

    2015-12-01

    Phosphoinositide specific phospholipase Cγ (PLCγ) activates diacylglycerol (DAG)/protein kinase C (PKC) and inositol 1,4,5-trisphosphate (IP3)/Ca(2+)/calmodulin-dependent protein kinase II (CaMK II) axes to regulate import events in some cancer cells, including gastric adenocarcinoma cells. However, whether DAG/PKCδ and IP3/Ca(2+)/CaMK IIβ axes are simultaneously involved in PLCγ1-driven cell proliferation and migration of human gastric adenocarcinoma cells and the underlying mechanism are not elucidated. Here, we investigated the role of DAG/PKCδ or CaMK IIβ in PLCγ1-driven cell proliferation and migration of human gastric adenocarcinoma cells, using the BGC-823 cell line. The results indicated that the inhibition of PKCδ and CaMK IIβ could block cell proliferation and migration of BGC-823 cells as well as the effect of inhibiting PLCγ1, including the decrease of cell viability, the increase of apoptotic index, the down-regulation of matrix metalloproteinase (MMP) 9 expression level, and the decrease of cell migration rate. Both DAG/PKCδ and CaMK IIβ triggered protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/S6 pathway to regulate protein synthesis. The data indicate that DAG/PKCδ and IP3/Ca(2+)/CaMK IIβ operate in parallel to each other in PLCγ1-driven cell proliferation and migration of human gastric adenocarcinoma cells through Akt/mTOR/S6 pathway, with important implication for validating PLCγ1 as a molecular biomarker in early gastric cancer diagnosis and disease surveillance.

  10. Phylogeny of Plant Calcium and Calmodulin-Dependent Protein Kinases (CCaMKs) and Functional Analyses of Tomato CCaMK in Disease Resistance

    PubMed Central

    Wang, Ji-Peng; Munyampundu, Jean-Pierre; Xu, You-Ping; Cai, Xin-Zhong

    2015-01-01

    Calcium and calmodulin-dependent protein kinase (CCaMK) is a member of calcium/calmodulin-dependent protein kinase superfamily and is essential to microbe- plant symbiosis. To date, the distribution of CCaMK gene in plants has not yet been completely understood, and its function in plant disease resistance remains unclear. In this study, we systemically identified the CCaMK genes in genomes of 44 plant species in Phytozome and analyzed the function of tomato CCaMK (SlCCaMK) in resistance to various pathogens. CCaMKs in 18 additional plant species were identified, yet the absence of CCaMK gene in green algae and cruciferous species was confirmed. Sequence analysis of full-length CCaMK proteins from 44 plant species demonstrated that plant CCaMKs are highly conserved across all domains. Most of the important regulatory amino acids are conserved throughout all sequences, with the only notable exception being observed in N-terminal autophosphorylation site corresponding to Ser 9 in the Medicago truncatula CCaMK. CCaMK gene structures are similar, mostly containing six introns with a phase profile of 200200 and the exception was only noticed at the first exons. Phylogenetic analysis demonstrated that CCaMK lineage is likely to have diverged early from a calcium-dependent protein kinase (CDPK) gene in the ancestor of all nonvascular plant species. The SlCCaMK gene was widely and differently responsive to diverse pathogenic stimuli. Furthermore, knock-down of SlCCaMK reduced tomato resistance to Sclerotinia sclerotiorum and Pseudomonas syringae pv. tomato (Pst) DC3000 and decreased H2O2 accumulation in response to Pst DC3000 inoculation. Our results reveal that SlCCaMK positively regulates disease resistance in tomato via promoting H2O2 accumulation. SlCCaMK is the first CCaMK gene proved to function in plant disease resistance. PMID:26697034

  11. The jet in crossflowa)

    NASA Astrophysics Data System (ADS)

    Karagozian, Ann R.

    2014-10-01

    The jet in crossflow, or transverse jet, is a flowfield that has relevance to a wide range of energy and propulsion systems. Over the years, our group's studies on this canonical flowfield have focused on the dynamics of the vorticity associated with equidensity and variable density jets in crossflow, including the stability characteristics of the jet's upstream shear layer, as a means of explaining jet response to altered types of excitation. The jet's upstream shear layer is demonstrated to exhibit convectively unstable behavior at high jet-to-crossflow momentum flux ratios, transitioning to absolutely unstable behavior at low momentum flux and/or density ratios, with attendant differences in shear layer vorticity evolution and rollup. These differences in stability characteristics are shown to have a significant effect on how one optimally employs external excitation to control jet penetration and spread, depending on the flow regime and specific engineering application. Yet recent unexpected observations on altered transverse jet structure under different flow conditions introduce a host of unanswered questions, primarily but not exclusively associated with the nature of molecular mixing, that make this canonical flowfield one that is of great interest for more extensive exploration.

  12. Should we select for genetic moral enhancement? A thought experiment using the MoralKinder (MK+) haplotype.

    PubMed

    Faust, Halley S

    2008-01-01

    By using preimplantation haplotype diagnosis, prospective parents are able to select embryos to implant through in vitro fertilization. If we knew that the naturally-occurring (but theoretical) MoralKinder (MK+) haplotype would predispose individuals to a higher level of morality than average, is it permissible or obligatory to select for the MK+ haplotype? I.e., is it moral to select for morality? This paper explores the various potential issues that could arise from genetic moral enhancement.

  13. Effect of chronic MK-801 and/or phenytoin on the acquisition of complex behaviors in rats.

    PubMed

    Wright, L K M; Popke, E J; Allen, R R; Pearson, E C; Hammond, T G; Paule, M G

    2007-01-01

    The purpose of the present experiment was to assess the effects of chronic MK-801 (an N-methyl-D-aspartate receptor antagonist) and/or phenytoin (a sodium channel blocker) treatment on behavioral acquisition and performance in rats. Learning, audio/visual discrimination and motivation were modeled using incremental repeated acquisition (IRA), audio/visual discrimination (AVD) and progressive ratio (PR) tasks, respectively. MK-801 and/or phenytoin were administered daily, 7 days/week by orogastric gavage beginning just after weaning on postnatal day (PND) 23 and continuing until PND 306. Monday through Friday behavioral assessments began on PND 27 and continued until PND 430. Throughout treatment, subjects in the high dose MK-801 (1.0 mg/kg/day) and the high dose drug combination (1.0 mg/kg/day MK-801+150 mg/kg/day phenytoin) groups exhibited decreased body weight gains compared to control subjects. For these two affected groups, response rates were also decreased in all tasks. Task acquisition, as evidenced by an increase in response accuracy, was decreased for both these groups in the AVD task, but only for the high dose MK-801 group in the IRA task. The data suggest that chronic MK-801 treatment adversely affects the acquisition of IRA and AVD task performance and that the inclusion of phenytoin in the MK-801 dosing regimen blocks some of the adverse effects of chronic MK-801 treatment on IRA task acquisition. These findings are in marked contrast with those observed in nonhuman primates and suggest important species differences associated with chronic exposure to compounds that block NMDA receptors and/or sodium channels.

  14. A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)

    PubMed Central

    Yamaguchi, Nobuko; Sato, Yasunori; Nagashima, Kengo; Katayama, Kanako; Sekiguchi, Yukari; Iwai, Yuta; Amino, Hiroshi; Suichi, Tomoki; Yokota, Takanori; Nishida, Yoichiro; Kohara, Nobuo; Hirata, Koichi; Nishiyama, Kazutoshi; Yabe, Ichiro; Kaida, Ken-Ichi; Suzuki, Norihiro; Nodera, Hiroyuki; Tsuji, Shoji; Koike, Haruki; Kira, Jun-Ichi; Hanaoka, Hideki; Kusunoki, Susumu; Kuwabara, Satoshi

    2016-01-01

    Background Guillain-Barré syndrome (GBS) is an immune-mediated neuropathy that causes acute flaccid paralysis. Immunoglobulin and plasma exchange are established treatments for GBS; however, a substantial number of patients, particularly those with severe disease, have poor recovery and residual deficits. Recent studies suggest that complement activation plays a pivotal role in GBS-associated axonal degeneration, and eculizumab is a humanized monoclonal antibody that specifically binds to complement component 5 and potently inhibits complement activation. Objective This clinical trial aims to evaluate the efficacy and safety of eculizumab, a humanized monoclonal antibody directed against complement component 5, for treatment of GBS. Methods The Japanese Eculizumab Trial for GBS (JET-GBS) is a prospective, multicenter, placebo-controlled, double-blind, randomized phase II study conducted at 13 tertiary neurology centers and is funded by the Japan Agency for Medical Research and Development. A total of 33 GBS patients unable to walk independently within 2 weeks from symptom onset (Hughes functional grade 3-5) were randomized at a 2:1 ratio to receive either intravenous eculizumab (900 mg/day) or placebo once weekly for 4 weeks, followed by 20 weeks of follow-up. The primary endpoint for efficacy is the proportion of patients who regain their ability to walk without aid at 4 weeks after the first dose of the study treatment, while primary safety outcomes are the incidence of adverse events and serious adverse events during the trial. Results Enrollment for the trial began in August 2015. This trial is still ongoing. All participants have been enrolled, and follow-up will be completed in October 2016. Conclusions This study is the first to investigate the efficacy and safety of eculizumab for GBS. In case of a positive result, we will plan a phase III trial to investigate this issue in a larger number of patients. ClinicalTrial UMIN Clinical Trials Registry UMIN

  15. MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux☆

    PubMed Central

    Barrington, Robert D.; Needs, Paul W.; Williamson, Gary; Kroon, Paul A.

    2015-01-01

    MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. Numerous reports have described modulation of Caco-2 cellular efflux and transport of flavonoids in the presence of MK571. Since flavonoids are efficiently conjugated by Caco-2/TC7 cells, we investigated the effects of MK571 on the efflux of flavonoid conjugates. The flavonol aglycones kaempferol, quercetin and galangin were efficiently taken up, conjugated and effluxed by Caco-2/TC7 cells. Apically-applied MK571 caused significant reductions in both the apical and basolateral efflux of flavonol conjugates from Caco-2/TC7 monolayers. MK571 did not significantly alter the apical:basolateral efflux ratio for flavonol conjugates, however, which is not consistent with MK571 specifically inhibiting only apical Mrp2. Since MK571 decreased the total amounts of conjugates formed, and increased cellular flavonol aglycone concentrations, we explored the possibility that MK571 also inhibits phase-2 conjugation of flavonols. MK571 dose-dependently inhibited the intracellular biosynthesis of all flavonol glucuronides and sulphates by Caco-2 cells. MK571 significantly inhibited phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. These data show that MK571, in addition to inhibiting MRP2, is a potential inhibitor of enterocyte phase-2 conjugation. PMID:25801004

  16. [Effect of mPGES-1 inhibitor MK886 on apoptosis and drug resistance of HL-60/A cells].

    PubMed

    Li, Yi-Qing; Yin, Song-Mei; Nie, Da-Nian; Xie, Shuang-Feng; Ma, Li-Ping; Wang, Xiu-Ju; Wu, Yu-Dan

    2012-08-01

    This study was aimed to investigate the effect of MK886, a mPGES-1 inhibitor, on apoptosis and drug resistance of leukemia HL-60/A cell line. Expression of mPGES-1 was assayed by QT-PCR and Western blot. The effect of MK886 on HL-60/A cell proliferation was assayed by CCK-8 method, and flow cytometry was used to detect cell apoptosis. The expression of Akt and P-Akt was detected by Western blot. PGE2 was measured by ELISA. Effect of MK886 (10 µmol/L) on the chemotherapeutic sensitivity of HL-60/A cells and expression of mdr-1 mRNA and P170 protein were investigated too. The results indicated the expression of mPGES-1 was higher in HL-60/A cells. MK886 inhibited HL-60/A cell proliferation and induced apoptosis in a time- and concentration-dependent manner. Expression of mPGES-1 and P-Akt and synthesis of PGE2 decreased significantly. MK886 reduced expression of mdr-1 and P170 protein and enhanced the sensitivity of HL-60/A cells to chemotherapeutic drugs. It is concluded that MK886 can inhibit HL-60/A cell proliferation, induce apoptosis and enhance sensitivity to chemotherapeutic drugs, the mechanism of which possibly associates to down-regulation of mPGES-1/PGE2 synthesis, reduction P-Akt expression and decreasing mdr-1 and P170 protein expression.

  17. Radiative versus Jet Mode in Radio Galaxies

    NASA Astrophysics Data System (ADS)

    Hardcastle, Martin

    2016-07-01

    In the local universe, the vast majority of radio-loud active galaxies show none of the conventional AGN apparatus of accretion disk, torus, corona, or broad/narrow-line regions. Instead such nuclear emission as they have appears to be completely dominated by emission directly from the jet; the accretion, which must be present to drive the jet, appears to be highly radiatively inefficient. However, the most radio-luminous objects in the universe are almost all quasars (type I or type II) which behave in the textbook manner, appearing as a normal radiatively efficient AGN with the addition of a jet. The past decade has seen a substantial evolution in our understanding of the physical origins of these differences, their relation to the host galaxy and environment, and their interpretation in terms of completely unified models of AGN, and I will review our current understanding of these issues in my talk.

  18. JetStar in flight

    NASA Technical Reports Server (NTRS)

    1981-01-01

    aircraft provided far-field acoustic data. Between May 21, 1981 and August of 1982, the JetStar completed roughly 45 research flights with three different propellers in varying configurations. Dryden engineers analyzed some of the resultant data, while they sent flight tapes to Hamilton Standard, Lewis, and Langley for analysis there. The results indicated a need for noise-reduction technology to keep the noise levels down to the project goals. An improved version of the advanced turboprop underwent flight testing in 1987 on a Gulfstream II over Georgia in 1987. These flight tests verified predictions of a 20- to 30-percent fuel savings. However, with the end of the energy crisis, the need for such savings disappeared, and the Advanced Turboprop Project did not lead to the expected industry-wide adoption of the new propeller systems on transport aircraft. In the 1960s, the same JetStar that was used to test the advanced turboprop had been equipped with an electronic variable-stability flight-control system. Called then a General Purpose Airborne Simulator (GPAS), the aircraft could duplicate the flight characteristics of a wide variety of advanced aircraft and was used for supersonic transport and general aviation research, and as a training and support system for Space Shuttle Approach and Landing Tests at Dryden in 1977. Over the years, the JetStar has also been used for a variety of other flight research projects, including laminar-flow-control flight tests in the mid-1980s.

  19. Jet lag modification.

    PubMed

    Simmons, Emily; McGrane, Owen; Wedmore, Ian

    2015-01-01

    Athletes often are required to travel for sports participation, both for practice and competition. A number of those crossing multiple time zones will develop jet lag disorder with possible negative consequences on their performance. This review will discuss the etiology of jet lag disorder and the techniques that are available to shorten or minimize its effects. This includes both pharmacological and nonpharmacological approaches.

  20. Jet measurements in ATLAS

    NASA Astrophysics Data System (ADS)

    Loch, Peter; ATLAS Collaboration

    2011-11-01

    The reconstruction of jets generated in the proton-proton collisions at the Large Hadron Collider (LHC) at a center of mass energy of TeV with the ATLAS detector is discussed. Beginning with a brief review of the calorimeter signal definitions relevant for jet finding, and the use of reconstructed charged particle tracks, the jet reconstruction strategy is described in some detail. Emphasis is put on the jet energy scale (JES) calibration strategy applied for first data, which is based on a short sequence of data driven and simulation based calibrations and corrections to restore the measured jet energy to particle level. The level of understanding of the signal patterns entering the JES corrections is shown for selected variables in comparisons to simulations. The present systematic uncertainties on the JES, which can be as low as 2% for central jets, are presented and analyzed with respect to the individual fractional contributions entering their determination. Some characteristic jet reconstruction performance and selected results from the first year of jet physics with ATLAS in a newly accessible kinematic domain are shown in conclusion.

  1. Jet Lag in Athletes

    PubMed Central

    Lee, Aaron; Galvez, Juan Carlos

    2012-01-01

    Context: Prolonged transmeridian air travel can impart a physical and emotional burden on athletes in jet lag and travel fatigue. Jet lag may negatively affect the performance of athletes. Study Type: Descriptive review. Evidence Acquisition: A Medline search for articles relating to jet lag was performed (1990-present), as was a search relating to jet lag and athletes (1983-January, 2012). The results were reviewed for relevance. Eighty-nine sources were included in this descriptive review. Results: Behavioral strategies are recommended over pharmacological strategies when traveling with athletes; pharmacological aides may be used on an individual basis. Strategic sleeping, timed exposure to bright light, and the use of melatonin are encouraged. Conclusions: There is strong evidence that mood and cognition are adversely affected by jet lag. Some measures of individual and team performance are adversely affected as well. PMID:23016089

  2. Relativistic Jets and Collapsars

    NASA Astrophysics Data System (ADS)

    Zhang, W.; Woosley, S. E.

    2001-05-01

    In order to study the relativistic jets from collapsars, we have developed a special relativistic multiple-dimensional hydrodynamics code similar to the GENESIS code (Aloy et al., ApJS, 122, 151). The code is based on the PPM interpolation algorithm and Marquina's Riemann solver. Using this code, we have simulated the propagation of axisymmetric jets along the rotational axis of collapsed rotating stars (collapsars). Using the progenitors of MacFadyen, Woosley, and Heger, a relativistic jet is injected at a given inner boundary radius. This radius, the opening angle of the jet, its Lorentz factor, and its total energy are parameters of the problem. A highly collimated, relativistic outflow is observed at the surface of the star several seconds later. We will discuss the hydrodynamical focusing of the jet, it's break out properties, time evolution, and sensitivity to the adopted parameters.

  3. Description of Jet Breakup

    NASA Technical Reports Server (NTRS)

    Papageorgiou, Demetrios T.

    1996-01-01

    In this article we review recent results on the breakup of cylindrical jets of a Newtonian fluid. Capillary forces provide the main driving mechanism and our interest is in the description of the flow as the jet pinches to form drops. The approach is to describe such topological singularities by constructing local (in time and space) similarity solutions from the governing equations. This is described for breakup according to the Euler, Stokes or Navier-Stokes equations. It is found that slender jet theories can be applied when viscosity is present, but for inviscid jets the local shape of the jet at breakup is most likely of a non-slender geometry. Systems of one-dimensional models of the governing equations are solved numerically in order to illustrate these differences.

  4. Instability of rectangular jets

    NASA Technical Reports Server (NTRS)

    Tam, Christopher K. W.; Thies, Andrew T.

    1992-01-01

    The instability of rectangular jets is investigated using a vortex sheet model. It is shown that such jets support four linearly independent families of instability waves. Within each family there are infinitely many modes. A way to classify these modes according to the characteristics of their mode shapes or eigenfunctions is proposed. A parametric study of the instability wave characteristics has been carried out. A sample of the numerical results is reported here. It is found that the first and third modes of each instability wave family are corner modes. The pressure fluctuations associated with these instability waves are localized near the corners of the jet. The second mode, however, is a center mode with maximum fluctuations concentrated in the central portion of the jet flow. The center mode has the largest spatial growth rate. It is anticipated that as the instability waves propagate downstream the center mode would emerge as the dominant instability of the jet.

  5. Jet physics at CDF

    SciTech Connect

    Melese, P.

    1997-05-01

    We present high E{sub T} jet measurements from CDF at the Fermilab Tevatron Collider. The incfilusive jet cross section at {radical}s = 1800 GeV with {approximately} 5 times more data is compared to the published CDF results, preliminary D0 results, and next-to-leading order QCD predictions. The {summation}E{sub T} cross section is also compared to QCD predictions and the dijet angular distribution is used to place a limit on quark compositeness. The inclusive jet cross section at {radical}s = 630 GeV is compared with that at 1800 GeV to test the QCD predictions for the scaling of jet cross sections with {radical}s. Finally, we present momentum distributions of charged particles in jets and compare them to Modified Leading Log Approximation predictions.

  6. The intelligibility of speech presented over the telephones of the Mk 4 flying helmet

    NASA Astrophysics Data System (ADS)

    Cogger, M. K.

    1980-03-01

    The intelligibility of speech presented over the earphones of the Mk 4 flying helmet was assessed using the procedure laid down in the Type Test Schedule. Results obtained using three phonetically balanced word lists presented to six subjects on two occasions indicate that speech intelligibility reaches 80 percent, the criterion of acceptability laid down in the schedule. Frequency response curves for the transducer earpiece assemblies of the helmet are given. The total harmonic distortion of the equipment used to present the spoken word lists is shown.

  7. Aging jets from low-mass stars

    NASA Technical Reports Server (NTRS)

    Graham, J. A.; Chen, W. P.

    1994-01-01

    An extended faint optical jet is associated with the compact emission region plus faint star known as HH 55. HH 55 is located in the Lupus 2 cloud 2 min SW of the well studied T Tauri star RU Lupi. The HH 55 jet extends 55 sec N and 35 sec S in PA 160 deg. The HH 55 star is an emission line star of spectral type M3.5. Its image in the emission lines of H-alpha and (S II) is slightly elongated by 2 sec - 3 sec to the S but in continuum light is symmetrical and pointlike ((full width at half maximum) (FWHM) = 1.7 sec). The star and jet have several features in common with the star and jet known as Sz 102 = Th 28 in the nearby Lupus 3 cloud. We suggest that these objects are representative of the late evolutionary stage of the HH jet-outflow phenomenon and point out that such objects may be quite common although difficult to detect. With L(sub bol) approximately = 0.005 solar luminosity, and log T(sub e) approximately = 3.5, the HH 55 star is close to the main sequence and evolutionary tracks suggest an age of 3 x 10(exp 7) yr.

  8. The cool component and the dichotomy, lateral expansion, and axial rotation of solar X-ray jets

    SciTech Connect

    Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.; Robe, Dominic

    2013-06-01

    We present results from a study of 54 polar X-ray jets that were observed in coronal X-ray movies from the X-ray Telescope on Hinode and had simultaneous coverage in movies of the cooler transition region (T ∼ 10{sup 5} K) taken in the He II 304 Å band of the Atmospheric Imaging Assembly (AIA) on Solar Dynamics Observatory. These dual observations verify the standard-jet/blowout-jet dichotomy of polar X-ray jets previously found primarily from XRT movies alone. In accord with models of blowout jets and standard jets, the AIA 304 Å movies show a cool (T ∼ 10{sup 5} K) component in nearly all blowout X-ray jets and in a small minority of standard X-ray jets, obvious lateral expansion in blowout X-ray jets but none in standard X-ray jets, and obvious axial rotation in both blowout X-ray jets and standard X-ray jets. In our sample, the number of turns of axial rotation in the cool-component standard X-ray jets is typical of that in the blowout X-ray jets, suggesting that the closed bipolar magnetic field in the jet base has substantial twist not only in all blowout X-ray jets but also in many standard X-ray jets. We point out that our results for the dichotomy, lateral expansion, and axial rotation of X-ray jets add credence to published speculation that type-II spicules are miniature analogs of X-ray jets, are generated by granule-size emerging bipoles, and thereby carry enough energy to power the corona and solar wind.

  9. Optimal Jet Finder

    NASA Astrophysics Data System (ADS)

    Grigoriev, D. Yu.; Jankowski, E.; Tkachov, F. V.

    2003-09-01

    We describe a FORTRAN 77 implementation of the optimal jet definition for identification of jets in hadronic final states of particle collisions. We discuss details of the implementation, explain interface subroutines and provide a usage example. The source code is available from http://www.inr.ac.ru/~ftkachov/projects/jets/. Program summaryTitle of program: Optimal Jet Finder (OJF_014) Catalogue identifier: ADSB Program Summary URL:http://cpc.cs.qub.ac.uk/summaries/ADSB Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computer: Any computer with the FORTRAN 77 compiler Tested with: g77/Linux on Intel, Alpha and Sparc; Sun f77/Solaris (thwgs.cern.ch); xlf/AIX (rsplus.cern.ch); MS Fortran PowerStation 4.0/Win98 Programming language used: FORTRAN 77 Memory required: ˜1 MB (or more, depending on the settings) Number of bytes in distributed program, including examples and test data: 251 463 Distribution format: tar gzip file Keywords: Hadronic jets, jet finding algorithms Nature of physical problem: Analysis of hadronic final states in high energy particle collision experiments often involves identification of hadronic jets. A large number of hadrons detected in the calorimeter is reduced to a few jets by means of a jet finding algorithm. The jets are used in further analysis which would be difficult or impossible when applied directly to the hadrons. Grigoriev et al. [ hep-ph/0301185] provide a brief introduction to the subject of jet finding algorithms and a general review of the physics of jets can be found in [Rep. Prog. Phys. 36 (1993) 1067]. Method of solution: The software we provide is an implementation of the so-called optimal jet definition ( OJD). The theory of OJD was developed by Tkachov [Phys. Rev. Lett. 73 (1994) 2405; 74 (1995) 2618; Int. J. Mod. Phys. A 12 (1997) 5411; 17 (2002) 2783]. The desired jet configuration is obtained as the one that minimizes Ω R, a certain function of the input particles and jet

  10. Simulations of Solar Jets

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2017-02-01

    Formation of a coronal jet from twisted field lines that have reconnected with the ambient field. The colors show the radial velocity of the plasma. [Adapted from Szente et al. 2017]How do jets emitted from the Suns surface contribute to its corona and to the solar wind? In a recent study, a team of scientists performed complex three-dimensional simulations of coronal jets to answer these questions.Small ExplosionsCoronal jets are relatively small eruptions from the Suns surface, with heights of roughly 100 to 10,000 km, speeds of 10 to 1,000 km/s, and lifetimes of a few minutes to around ten hours. These jets are constantly present theyre emitted even from the quiet Sun, when activity is otherwise low and weve observed them with a fleet of Sun-watching space telescopes spanning the visible, extreme ultraviolet (EUV), and X-ray wavelength bands.A comparison of simulated observations based on the authors model (left panels) to actual EUV and X-ray observations of jets (right panels). [Szente et al. 2017]Due to their ubiquity, we speculate that these jets might contribute to heating the global solar corona (which is significantly hotter than the surface below it, a curiosity known as the coronal heating problem). We can also wonder what role these jets might play in driving the overall solar wind.Launching a JetLed by Judit Szente (University of Michigan), a team of scientists has explored the impact of coronal jets on the global corona and solar wind with a series of numerical simulations. Szente and collaborators used three-dimensional, magnetohydrodynamic simulations that provide realistic treatment of the solar atmosphere, the solar wind acceleration, and the complexities of heat transfer throughout the corona.In the authors simulations, a jet is initiated as a magnetic dipole rotates at the solar surface, winding up field lines. Magnetic reconnection between the twisted lines and the background field then launches the jet from the dense and hot solar

  11. Subchronic Exposure to Arsenic Represses the TH/TRβ1-CaMK IV Signaling Pathway in Mouse Cerebellum

    PubMed Central

    Guan, Huai; Li, Shuangyue; Guo, Yanjie; Liu, Xiaofeng; Yang, Yi; Guo, Jinqiu; Li, Sheng; Zhang, Cong; Shang, Lixin; Piao, Fengyuan

    2016-01-01

    We previously reported that arsenic (As) impaired learning and memory by down-regulating calmodulin-dependent protein kinase IV (CaMK IV) in mouse cerebellum. It has been documented that the thyroid hormone receptor (TR)/retinoid X receptor (RXR) heterodimer and thyroid hormone (TH) may be involved in the regulation of CaMK IV. To investigate whether As affects the TR/RXR heterodimer and TH, we determined As concentration in serum and cerebellum, 3,5,3’-triiodothyronine (T3) and thyroxin (T4) levels in serum, and expression of CaMK IV, TR and RXR in cerebellum of mice exposed to As. Cognition function was examined by the step-down passive avoidance task and Morris water maze (MWM) tests. Morphology of the cerebellum was observed by Hematoxylin-Eosin staining under light microscope. Our results showed that the concentrations of As in the serum and cerebellum of mice both increased with increasing As-exposure level. A significant positive correlation was found between the two processes. Adeficit in learning and memory was found in the exposed mice. Abnormal morphologic changes of Purkinje cells were observed in cerebellum of the exposed mice. Moreover, the cerebellar expressions of CaMK IV protein and the TRβ gene, and TRβ1 protein were significantly lower in As-exposed mice than those in controls. Subchronic exposure to As appears to increase its level in serum and cerebella of mice, impairing learning and memory and down-regulating expression of TRβ1 as well as down-stream CaMK IV. It is also suggested that the increased As may be responsible for down-regulation of TRβ1 and CaMK IV in cerebellum and that the down-regulated TRβ1 may be involved in As-induced impairment of learning and memory via inhibiting CaMK IV and its down-stream pathway. PMID:26821021

  12. Measurement of the WW and WZ production cross section using final states with a charged lepton and heavy-flavor jets in the full CDF Run II data set

    SciTech Connect

    Aaltonen, T.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d’Ascenzo, N.; Datta, M.; De Barbaro, P.; Demortier, L.; Deninno, M.; Devoto, F.; d’Errico, M.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; D’Onofrio, M.; Donati, S.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Eusebi, R.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kim, Y. J.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, P.; Martínez, M.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Prokoshin, F.; Pranko, A.; Ptohos, F.; Punzi, G.; Ranjan, N.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Riddick, T.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Safonov, A.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sinervo, P.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Sorin, V.; Song, H.; Stancari, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vázquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizán, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Wester, W. C.; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W. -M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Zanetti, A. M.; Zeng, Y.; Zhou, C.; Zucchelli, S.

    2016-08-23

    We present a measurement of the total WW and WZ production cross sections in $p\\bar{p}$ collision at $\\sqrt{s}$ = 1.96 TeV, in a final state consistent with leptonic W boson decay and jets originating from heavy-flavor quarks from either a W or a Z boson decay. This analysis uses the full data set collected with the CDF II detector during Run II of the Tevatron collider, corresponding to an integrated luminosity of 9.4 fb-1. An analysis of the dijet mass spectrum provides 3.7σ evidence of the summed production processes of either WW or WZ bosons with a measured total cross section of σWW+WZ = 13.7±3.9 pb. Independent measurements of the WW and WZ production cross sections are allowed by the different heavy-flavor decay patterns of the W and Z bosons and by the analysis of secondary-decay vertices reconstructed within heavy-flavor jets. The productions of WW and of WZ dibosons are independently seen with significances of 2.9σ and 2.1σ, respectively, with total cross sections of σWW = 9.4±4.2 pb and σWZ = 3.7$+2.5\\atop{-2.2}$ pb. Lastly, the measurements are consistent with standard-model predictions.

  13. The effect of jet shape on jet injection.

    PubMed

    Park, Geehoon; Modak, Ashin; Hogan, N Catherine; Hunter, Ian W

    2015-01-01

    The effects of the dispersion pattern of a needle-free jet injector are explored. The shape of the jets were compared using a high-speed video camera and jet injections of collimated and dispersed fluid jets with a Lorentz-force actuated jet injector were made into acrylamide gel and post-mortem porcine tissue. A custom-built high-speed X-ray imaging system was used in order to observe the dynamics of the dispersion mechanism for each injection in real time. We show that a collimated jet stream results in greater tissue penetration than a dispersed jet stream.

  14. MK-801 is neuroprotective but does not improve survival in severe forebrain ischemia.

    PubMed

    Von Lubitz, D K; McKenzie, R J; Lin, R C; Devlin, T M; Skolnick, P

    1993-03-16

    The effects of MK-801 on postischemic recovery, survival and neuronal preservation in the cortex, hippocampus and striatum were studied in Mongolian gerbils. The drug was administered 30 min prior to 20 of min forebrain ischemia induced by bilateral ligation of the carotids. Neurological recovery and survival were monitored for 7 days. At the end of the monitoring period neuronal damage was analyzed in the brains of the survivors in both groups. Treatment with MK-801 did not improve either neurological recovery or end-point survival. However, significant (P < 0.01) neuronal protection was observed in the hippocampi and striata of the drug treated animals while cortical neurons were not significantly protected. These findings demonstrate that protection against ischemic neuronal damage can be observed without concomitant improvement in either postischemic neurological recovery or survival. Protection of selectively vulnerable brain regions, often used as the predictor of the therapeutic potential of an agent, does not appear to correlate well with postischemic survival in this animal model of ischemia.

  15. ACTH4 -10, Substance P, and Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

    PubMed Central

    Mattioli, R.; Huston, J. P.; Spieler, R. E.

    2000-01-01

    In this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were tested–namely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK- 801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion of the right labyrinth, the animals (n=12) were treated intraperitoneally daily either with vehicle (n=12), substance P (n=11), ACTH4-10 (n=12), or MK- 801 (n=12). Another group (n=11), which served as a non-lesion control, did not receive hemilabyrinthectomy or systemic injections. The lesion group, treated post-operatively with vehicle, did not recover from the postural deviation over the 24-d testing period. In contrast, all three test substances accelerated the functional recovery after unilateral labyrinthectomy. The decrease of the dorsal light reflex persisted even after cessation of drug treatment after 20d. The results indicate that using the dorsal light reflex in the model of hemilabyrinthectomy in goldfish provides a useful approach to studying the ability of potential new neurotrophic or neuroprotective drugs to promote functional recovery. PMID:11486488

  16. Gray Box Optimization for Mk Landscapes (NK Landscapes and MAX-kSAT).

    PubMed

    Whitley, L Darrell; Chicano, Francisco; Goldman, Brian W

    2016-01-01

    This article investigates Gray Box Optimization for pseudo-Boolean optimization problems composed of M subfunctions, where each subfunction accepts at most k variables. We will refer to these as Mk Landscapes. In Gray Box Optimization, the optimizer is given access to the set of M subfunctions. We prove Gray Box Optimization can efficiently compute hyperplane averages to solve non-deceptive problems in [Formula: see text] time. Bounded separable problems are also solved in [Formula: see text] time. As a result, Gray Box Optimization is able to solve many commonly used problems from the evolutional computation literature in [Formula: see text] evaluations. We also introduce a more general class of Mk Landscapes that can be solved using dynamic programming and discuss properties of these functions. For certain type of problems Gray Box Optimization makes it possible to enumerate all local optima faster than brute force methods. We also provide evidence that randomly generated test problems are far less structured than those found in real-world problems.

  17. Synthetic Fence Jets

    NASA Astrophysics Data System (ADS)

    Sigurdson, Lorenz; Apps, Christopher

    2000-11-01

    "Synthetic Jets" have previously been produced where an oscillating flow with zero net mass flux acts on the edges of an orifice. The resulting flow is similar to a normal jet. We have proposed and verified that another type of jet called a "Synthetic Fence Jet" (SFJ or "fe-je") can also be created. We introduced a fence perpendicular to both a wall and an oscillating velocity field. Under certain conditions a jet was formed by vortices of alternating sign. The vortices were shed from the fence and they induced each other away from it. This phenomenon could be used as a method of flow control. The objective of this project was to use flow visualization to prove the existence of and characterize this jet. A test rig was used which incorporates smoke-wire flow visualization; independent oscillation level and frequency control; and computer- controlled data acquisition. It has been discovered that the jet direction can be vectored by altering the forcing waveform shape. To explain this a theory was developed that is based on the Biot-Savart law of vortex dynamics.

  18. Solar coronal jets

    NASA Astrophysics Data System (ADS)

    Dobrzyck, D.

    The solar jets were first observed by SOHO instruments (EIT, LASCO, UVCS) during the previous solar minimum. They were small, fast ejections originating from flaring UV bright points within large polar coronal holes. The obtained data provided us with estimates of the jet plasma conditions, dynamics, evolution of the electron temperature and heating rate required to reproduce the observed ionization state. To follow the polar jets through the solar cycle a special SOHO Joint Observing Program (JOP 155) was designed. It involves a number of SOHO instruments (EIT, CDS, UVCS, LASCO) as well as TRACE. The coordinated observations have been carried out since April 2002. The data enabled to identify counterparts of the 1996-1998 solar minimum jets. Their frequency of several events per day appear comparable to the frequency from the previous solar minimum. The jets are believed to be triggered by field line reconnection between emerging magnetic dipole and pre-existing unipolar field. Existing models predict that the hot jet is formed together with another jet of a cool material. The particular goal of the coordinated SOHO and TRACE observations was to look for possible association of the hot and cool plasma ejections. Currently there is observational evidence that supports these models.

  19. Jet Noise Suppression

    NASA Technical Reports Server (NTRS)

    Gliebe, P. R.; Brausch, J. F.; Majjigi, R. K.; Lee, R.

    1991-01-01

    The objectives of this chapter are to review and summarize the jet noise suppression technology, to provide a physical and theoretical model to explain the measured jet noise suppression characteristics of different concepts, and to provide a set of guidelines for evolving jet noise suppression designs. The underlying principle for all jet noise suppression devices is to enhance rapid mixing (i.e., diffusion) of the jet plume by geometric and aerothermodynamic means. In the case of supersonic jets, the shock-cell broadband noise reduction is effectively accomplished by the elimination or mitigation of the shock-cell structure. So far, the diffusion concepts have predominantly concentrated on jet momentum and energy (kinetic and thermal) diffusion, in that order, and have yielded better noise reduction than the simple conical nozzles. A critical technology issue that needs resolution is the effect of flight on the noise suppression potential of mechanical suppressor nozzles. A more thorough investigation of this mechanism is necessary for the successful development and design of an acceptable noise suppression device for future high-speed civil transports.

  20. Atmospheric Dispersion of High Velocity Jets.

    DTIC Science & Technology

    1979-11-01

    jet "penetrates" the atmosphere before coming essentially to rest relative to the ambient wind. Stationary sources such as engine run up test staids...used to non-dimensionalize or standardize the abscissa of the temperature profile. The standard deviations are ta- bulated in Tables I, II and III for...incidence was in- creased, the length normal to the wind direction where the dispersion tribution was essentially uniform (ie. sigma approaches infinity

  1. Jet Physics at CDF

    SciTech Connect

    Sally Seidel

    2004-06-28

    Jets have been studied by the CDF Collaboration [1] as a means of searching for new particles and interactions, testing a variety of perturbative QCD predictions, and providing input for the global parton distribution function (PDF) fits. Unless otherwise indicated below, the jets were reconstructed using a cone algorithm [2] with cone radius R = 0.7 from data taken at the Fermilab Tevatron collider in Run 2, 2001-2003, with {radical}s = 1.96 TeV. Central jets, in the pseudorapidity range relative to fixed detector coordinates 0.1 < |{eta}| < 0.7, are used.

  2. The FvMK1 mitogen-activated protein kinase gene regulates conidiation, pathogenesis, and fumonisin production in Fusarium verticillioides.

    PubMed

    Zhang, Yueping; Choi, Yoon-E; Zou, Xuexiao; Xu, Jin-Rong

    2011-02-01

    Fusarium verticillioides is one of the most important fungal pathogens to cause destructive diseases of maize worldwide. Fumonisins produced by the fungus are harmful to human and animal health. To date, our understanding of the molecular mechanisms associated with pathogenicity and fumonisin biosynthesis in F. verticillioides is limited. Because MAP kinase pathways have been implicated in regulating diverse processes important for plant infection in phytopathogenic fungi, in this study we identified and functionally characterized the FvMK1 gene in F. verticillioides. FvMK1 is orthologous to FMK1 in F. oxysporum and GPMK1 in F. graminearum. The Fvmk1 deletion mutant was reduced in vegetative growth and production of microconidia. However, it was normal in sexual reproduction and increased in the production of macroconidia. In infection assays with developing corn kernels, the Fvmk1 mutant was non-pathogenic and failed to colonize through wounding sites. It also failed to cause stalk rot symptoms beyond the inoculation sites on corn stalks, indicating that FvMK1 is essential for plant infection. Furthermore, the Fvmk1 mutant was significantly reduced in fumonisin production and expression levels of FUM1 and FUM8, two genes involved in fumonisin biosynthesis. The defects of the Fvmk1 mutant were fully complemented by re-introducing the wild type FvMK1 allele. These results demonstrate that FvMK1 plays critical roles in the regulation of vegetative growth, asexual reproduction, fumonisin biosynthesis, and pathogenicity.

  3. Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by Soman. (Reannouncement with new availability information)

    SciTech Connect

    Sparenborg, S.; Brennecke, L.H.; Jaax, N.K.; Braitman, D.J.

    1992-12-31

    The involvement of the NMDA receptor in the neurotoxicity induced by soman, an organophosphorus compound which irreversibly inhibits cholinesterase, was studied in guinea pigs. The drug MK-801 (0.5, 1 or 5 mg/kg, i.p.) was given as a pretreatment before a convulsant dose of soman or as a post treatment (30, 100 or 300 micron g/kg, i.m.) 5 min after the development of soman-induced status epilepticus. Pyridostigmine, atropine and pralidoxime chloride were also given to each subject to counteract the lethality of soman. All subjects that were challenged with soman and given the vehicle for MK-801 (saline) exhibited severe convulsions and electrographic seizure activity. Neuronal necrosis was found in the hippocampus, amygdala, thalamus and the pyriform and cerebral cortices of those subjects surviving for 48 hr. Pretreatment with 0.5 or 1 mg/kg doses of MK-801 did not prevent nor delay the onset of seizure activity but did diminish its intensity and led to its early arrest. At the largest dose (5 mg/kg), MK-801 completely prevented the development of seizure activity and brain damage. Post treatment with MK-801 prevented, arrested or reduced seizure activity, convulsions and neuronal necrosis in a dose-dependent manner. The NMDA receptor may play a more critical role in the spread and maintenance, rather than the initiation of cholinergically-induced seizure activity....Seizure-related brain damage, Organophosphorus compound, Nerve agent, Cholinesterase inhibition, Excitotoxicity, Guinea pig.

  4. Qualification campaign of the 50 mK hybrid sorption-ADR cooler for SPICA/SAFARI

    NASA Astrophysics Data System (ADS)

    Duval, J.-M.; Duband, L.; Attard, A.

    2015-12-01

    SAFARI (SpicA FAR-infrared Instrument) is an infrared instrument planned to be part of the SPICA (SPace Infrared telescope for Cosmology and Astrophysics) Satellite. It will offer high spectral resolution in the 30 - 210 μm frequency range. SAFARI will benefit from the cold telescope of SPICA and to obtain the required detectors sensitivity, a temperature of 50 mK is required. This temperature is reached thanks to the use of a hybrid sorption - ADR (Adiabatic Demagnetization Refrigerator) cooler presented here. This cooler provides respectively 14 μW and 0.4 μW of cooling power at 300 mK and 50 mK. The cooler is planned to advantageously use two thermal interfaces of the instrument at 1.8 and 4.9 K. One of the challenges discussed in this paper is the low power available at each intercept. A dedicated laboratory electronic is being designed based on previous development with a particular focus on the 50 mK readout. Temperature regulation at 50 mK is also discussed. This cooler has been designed following flight constraints and will reach a high TRL, including mechanical and environmental tests at the end of the on-going qualification campaign.

  5. Strain and colony differences in the neurotoxic sequelae of MK-801 visualized with the amino-cupric-silver method.

    PubMed

    Bueno, Adrian; de Olmos, Soledad; Manzini, Fernando; Desmond, Nancy L; de Olmos, Jose

    2003-11-01

    The strain and sex of a species under investigation may influence the animal's physiological response to a variety of stimuli. Strain and sex differences are important considerations when evaluating animal models. In the rodent MK-801 model of schizophrenia, degenerative changes occur widely in the main olfactory system and in a number of cortical brain regions. In the present report, we compare the effects of MK-801 neurotoxicity in two strains of female rats and also two lines within each strain. The magnitude and regional extent of the neurodegeneration detected with the amino-cupric-silver method varied markedly both between the Sprague-Dawley and Wistar rat strains and also between two lines derived from each strain. For example, terminal degeneration occurred in layer VI of somatosensory cortex and the central extended amygdala in Sprague-Dawley but not Wistar rats. Moreover, MK-801 treatment led to somatodendritic degeneration in the dentate gyrus of the dorsal hippocampus and basolateral amygdala in Wistar rats from Charles River Laboratories but not those from Ferreyra Institute. There are thus both strain and intrastrain differences in the magnitude of the neurodegenerative response to MK-801 treatment. The differing neurotoxicity of MK-801 between rat strains and between lines within a strain may reflect genetic variation and/or differences in hepatic biotransformation and thus the bioavailability of the drug between strains and lines within a strain.

  6. Multiwavelength Observations of AGN Jets: Untangling the Coupled Problems of Emission Mechanism and Jet Structure

    NASA Astrophysics Data System (ADS)

    Perlman, Eric S.; Avachat, Sayali S.; Clautice, Devon; Georganopoulos, Markos; Meyer, Eileen; Cara, Mihai

    2016-04-01

    The discovery of X-ray and optical emission from large numbers of AGN jets is one of the key legacies of the Chandra X-ray Observatory and Hubble Space Telescope. Several dozen optical and X-ray emitting jets are now known, most of which are seen in both bands as well as in the radio, where they were first discovered. Jets carry prodigious amounts of energy and mass out from the nuclear regions out to tens to hundreds of kiloparsecs distant from the central black hole, depositing it into the host galaxy and cluster. Interpreting their multiwavelength emissions has not been easy: while in most jets, the optical and radio emission in many objects is believed to emerge via the synchrotron process, due to its characteristic spectral shape and high radio polarization, the X-ray emission has been a tougher nut to crack. In less powerful, FR I jets, such as M87, the X-ray emission is believed to be synchrotron emission from the highest energy electrons, requiring in situ particle acceleration due to the short radiative lifetimes of the particles. However, in FR II and quasar jets, a variety of emission mechanisms are possible. Until the last few years, the leading interpretation had been inverse-Comptonization of Cosmic Microwave Background photons (the IC/CMB mechanism). This requires the jet to be relativistic out to hundreds of kiloparsecs from the nucleus, and requires an electron spectrum that extends to very low Lorentz factors. However, that now appears less likely, due to observed high optical polarizations in jets where the optical and X-ray emission appears to lie on the same spectral component, as well as limits derived from Fermi observations in the GeV gamma-rays. It now appears more likely that the X-rays must arise as synchrotron emission from a second, high energy electron population. With this revelation, we must tackle anew the coupling between jet structure and emission mechanisms. Multiwavelength imaging and polarimetry can give us clues to the

  7. Astrophysics: Cosmic jet engines

    NASA Astrophysics Data System (ADS)

    Young, Andy

    2010-02-01

    In some galaxies, matter falling onto a supermassive black hole is ejected in narrow jets moving at close to the speed of light. New observations provide insight into the workings of these cosmic accelerators.

  8. Dilution jet mixing program

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; Coleman, E.; Johnson, K.

    1984-01-01

    Parametric tests were conducted to quantify the mixing of opposed rows of jets (two-sided injection) in a confined cross flow. Results show that jet penetrations for two sided injections are less than that for single-sided injections, but the jet spreading rates are faster for a given momentum ratio and orifice plate. Flow area convergence generally enhances mixing. Mixing characteristics with asymmetric and symmetric convergence are similar. For constant momentum ratio, the optimum S/H(0) with in-line injections is one half the optimum value for single sided injections. For staggered injections, the optimum S/H(0) is twice the optimum value for single-sided injection. The correlations developed predicted the temperature distributions within first order accuracy and provide a useful tool for predicting jet trajectory and temperature profiles in the dilution zone with two-sided injections.

  9. Jet propulsion for airplanes

    NASA Technical Reports Server (NTRS)

    Buckingham, Edgar

    1924-01-01

    This report is a description of a method of propelling airplanes by the reaction of jet propulsion. Air is compressed and mixed with fuel in a combustion chamber, where the mixture burns at constant pressure. The combustion products issue through a nozzle, and the reaction of that of the motor-driven air screw. The computations are outlined and the results given by tables and curves. The relative fuel consumption and weight of machinery for the jet, decrease as the flying speed increases; but at 250 miles per hour the jet would still take about four times as much fuel per thrust horsepower-hour as the air screw, and the power plant would be heavier and much more complicated. Propulsion by the reaction of a simple jet can not compete with air screw propulsion at such flying speeds as are now in prospect.

  10. High resolution spectroscopy over lambda lambda 8500-8750 Å for GAIA. IV. Extending the cool MK stars sample

    NASA Astrophysics Data System (ADS)

    Marrese, P. M.; Boschi, F.; Munari, U.

    2003-08-01

    A library of high resolution spectra of MK standard and reference stars, observed in support to the GAIA mission, is presented. The aim of this paper is to integrate the MK mapping of Paper I of this series as well as to consider stars over a wider range of metallicities. Radial velocities are measured for all the target stars. The spectra are available in electronic form (ASCII format) at CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/406/995 and from the web page http://ulisse.pd.astro.it/MoreMK/, where further bibliographical information for the target stars is given.

  11. On the stability and energy dissipation in magnetized radio galaxy jets.

    NASA Astrophysics Data System (ADS)

    Bromberg, Omer; Tchekhovskoy, Alexander

    2016-07-01

    It is commonly accepted that the relativistic jets observed in radio galaxies are launched magnetically and are powered by the rotational energy of the central supermassive black hole. Such jets carry most of their energy in the form of electromagnetic Poynting flux. However by the time the ejecta reach the emission zone most of that energy is transferred to relativistic motions of the jet material with a large fraction given to non-thermal particles, which calls for an efficient dissipation mechanism to work within the jet without compromising its integrity. Understanding the energy dissipation mechanisms and stability of Poynting flux dominated jets is therefore crucial for modeling these astrophysical objects. In this talk I will present the first self consistent 3D simulations of the formation and propagation of highly magnetized (σ ˜25), relativistic jets in a medium. We find that the jets develop two types of instability: i) a local, "internal" kink mode which efficiently dissipates half of the magnetic energy into heat, and ii) a global "external" mode that grows on longer time scales and causes the jets to bend sideways and wobble. Low power jets propagating in media with flat density profiles, such as galaxy cluster cores, are susceptible to the global mode, and develop FRI like morphology. High power jets remain stable as they cross the cores, break out and accelerate to large distances, appearing as FRII jets. Thus magnetic kink instability can account for both the magnetic energy dissipation and the population dichotomy in radio galaxy jets.

  12. Relativistic Jets from Collapsars

    NASA Astrophysics Data System (ADS)

    Aloy, M. A.; Müller, E.; Ibáñez, J. M.; Martí, J. M.; MacFadyen, A.

    2000-03-01

    Using a collapsar progenitor model of MacFadyen & Woosley, we have simulated the propagation of an axisymmetric jet through a collapsing rotating massive star with the GENESIS multidimensional relativistic hydrodynamic code. The jet forms as a consequence of an assumed (constant or variable) energy deposition in the range of 1050-1051 ergs s-1 within a 30 deg cone around the rotation axis. The jet flow is strongly beamed (approximately less than a few degrees), spatially inhomogeneous, and time dependent. The jet reaches the surface of the stellar progenitor (R*=2.98x1010 cm) intact. At breakout, the maximum Lorentz factor of the jet flow is 33. After breakout, the jet accelerates into the circumstellar medium, whose density is assumed to decrease exponentially and then become constant, ρext=10-5 g cm-3. Outside the star, the flow begins to expand laterally also (v~c), but the beam remains very well collimated. At a distance of 2.54 R*, where the simulation ends, the Lorentz factor has increased to 44.

  13. Radiation from Relativistic Jets

    NASA Technical Reports Server (NTRS)

    Nishikawa, K.-I.; Mizuno, Y.; Hardee, P.; Sol, H.; Medvedev, M.; Zhang, B.; Nordlund, A.; Frederiksen, J. T.; Fishman, G. J.; Preece, R.

    2008-01-01

    Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks, e.g., gamma-ray bursts (GRBs), active galactic nuclei (AGNs), and Galactic microquasar systems usually have power-law emission spectra. Recent PIC simulations of relativistic electron-ion (electron-positron) jets injected into a stationary medium show that particle acceleration occurs within the downstream jet. In the presence of relativistic jets, instabilities such as the Buneman instability, other two-streaming instability, and the Weibel (filamentation) instability create collisionless shocks, which are responsible for particle (electron, positron, and ion) acceleration. The simulation results show that the Weibel instability is responsible for generating and amplifying highly nonuniform, small-scale magnetic fields. These magnetic fields contribute to the electron's transverse deflection behind the jet head. The 'jitter' radiation from deflected electrons in small-scale magnetic fields has different properties than synchrotron radiation which is calculated in a uniform magnetic field. This jitter radiation, a case of diffusive synchrotron radiation, may be important to understand the complex time evolution and/or spectral structure in gamma-ray bursts, relativistic jets, and supernova remnants.

  14. Axisymmetric wall jet development in confined jet impingement

    NASA Astrophysics Data System (ADS)

    Guo, Tianqi; Rau, Matthew J.; Vlachos, Pavlos P.; Garimella, Suresh V.

    2017-02-01

    The flow field surrounding an axisymmetric, confined, impinging jet was investigated with a focus on the early development of the triple-layered wall jet structure. Experiments were conducted using stereo particle image velocimetry at three different confinement gap heights (2, 4, and 8 jet diameters) across Reynolds numbers ranging from 1000 to 9000. The rotating flow structures within the confinement region and their interaction with the surrounding flow were dependent on the confinement gap height and Reynolds number. The recirculation core shifted downstream as the Reynolds number increased. For the smallest confinement gap height investigated, the strong recirculation caused a disruption of the wall jet development. The radial position of the recirculation core observed at this small gap height was found to coincide with the location where the maximum wall jet velocity had decayed to 15% of the impinging jet exit velocity. After this point, the self-similarity hypothesis failed to predict the evolution of the wall jet further downstream. A reduction in confinement gap height increased the growth rates of the wall jet thickness but did not affect the decay rate of the wall jet maximum velocity. For jet Reynolds numbers above 2500, the decay rate of the maximum velocity in the developing region of the wall jet was approximately -1.1, which is close to previous results reported for the fully developed region of radial wall jets. A much higher decay rate of -1.5 was found for the wall jet formed by a laminar impinging jet at Re = 1000.

  15. Competitive (AP7) and non-competitive (MK-801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex

    SciTech Connect

    Clow, D.W.; Lee, S.J.; Hammer, R.P. Jr. )

    1991-04-01

    The effects of D,L-2-amino-7-phosphonoheptanoic acid (AP7), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, and MK-801, a non-competitive NMDA receptor antagonist, on regional brain metabolism were studied in unanesthetized, freely moving rats by using the quantitative {sup 14}C2-deoxyglucose autoradiographic procedure. AP7 (338 or 901 mg/kg) produced a dose-dependent decrease of metabolic activity throughout most of the regions studied including sensory, motor, and limbic cortices. In contrast, MK-801 (0.1 or 1.0 mg/kg) resulted in a dose-dependent decrease of metabolic activity in sensory cortices, and an increase in limbic regions such as the hippocampal stratum lacunosum moleculare and entorhinal cortex. MK-801 also produced a biphasic response in agranular motor cortex, whereby the low dose increased while the high dose decreased labeling. In addition, MK-801 produced heterogeneous effects on regional cerebral metabolism in sensory cortices. Metabolic activity decreased in layer IV relative to layer Va following MK-801 treatment in primary somatosensory (SI) and visual (VI) cortices, suggesting a shift in activity from afferent fibers innervating layer IV to those innervating layer Va. MK-801 administration also decreased metabolic activity in granular SI relative to dysgranular SI, and in VI relative to secondary visual cortex (VII), thus providing a relative sparing of activity in dysgranular SI and VII. Thus, the non-competitive NMDA receptor antagonist suppressed activity from extrinsic neocortical sources, enhancing relative intracortical activity and stimulating limbic regions, while the competitive NMDA antagonist depressed metabolic activity in all cortical regions.

  16. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

    PubMed Central

    Siddiqui, Almas; Lacroix, Thomas; Stasko, Melissa R.; Scott-McKean, Jonah J.; Costa, Alberto C.S.; Gardiner, Katheleen J.

    2008-01-01

    Down syndrome, due to trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. The Ts65Dn mouse model of Down syndrome is trisomic for orthologs of 94 chr21-encoded confirmed protein coding genes and displays a number of behavioral deficits. Recently, Ts65Dn mice were shown to be hypersensitive to the locomotor stimulatory effects of the high affinity N-methyl-D-aspartate (NMDA) receptor (NMDAR) channel blocker, MK-801. This is consistent with the functions of several chr21 proteins that are predicted directly or indirectly to impact NMDA receptor function or NMDA receptor-mediated signaling. Here, we show that a second mouse model of Down syndrome, the Ts1Cje, which is trisomic for 70 protein coding genes, is also hypersensitive to MK-801. To investigate the molecular basis for the responses to MK-801, we have measured levels of a subset of chr21 and phosphorylated non-chr21 proteins, in the cortex and hippocampus of Ts65Dn and Ts1Cje mice and euploid controls, with and without treatment with MK-801. We show that, in euploid mice, the chr21-encoded proteins, TIAM1 and DYRK1A, and phosphorylation of Akt, Erk1/2 and the transcription factor Elk are involved in the MK-801 response. However, in both Ts65Dn and Ts1Cje mice, levels of phosphorylation are constitutively elevated in naïve, unstimulated mice and the MK-801 induced changes in TIAM1 and DYRK1A and in phosphorylation are either absent or abnormal, with both genotype and brain region-specific patterns. These results emphasize the complexities of the pathway perturbations that arise with segmental trisomy. PMID:19125866

  17. Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

    PubMed

    Li, Chaonan; Li, Li; Lin, Bencheng; Fang, Yanjun; Yang, Honglian; Liu, Huanliang; Xi, Zhuge

    2017-02-09

    Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaMK2a/2b, and tubulin α/β proteins; however, limited information is currently available on the toxicity and mechanism of TDCIPP. In the present study, cytotoxicity effects were evaluated by exposing PC12 cells to different concentrations of TDCIPP (0-50 μM) for 4 days. To explore the possible mechanisms through which cytotoxicity is induced, changes in intracellular [Ca(2+) ]i levels and the activation of calmodulin dependent protein kinase 2 (CaMK2), c-Jun N-terminal kinase (JNK), extracellular regulated protein kinases (ERK1/2), and p38 mitogen-activated protein kinases (MAPK) pathways were evaluated. Furthermore, PC12 cells were pretreated with CaMK2 inhibitor KN93 to investigate the relationship between TDCIPP-induced phosphorylation of CaMK2 and activation of JNK, ERK1/2, and p38 MAPK pathways. Our results indicate that TDCIPP-induced toxicity might be associated with the overload of [Ca(2+) ]i levels, increased phosphorylation of CaMK2, and activation of the JNK, ERK1/2, and p38 MAPK pathways, the lattermost of which was further demonstrated to be partially elicited by the CaMK2 phosphorylation.

  18. Temperature and density structure of a recurring active region jet

    NASA Astrophysics Data System (ADS)

    Mulay, Sargam M.; Zanna, Giulio Del; Mason, Helen

    2017-01-01

    Aims: We present a study of a recurring jet observed on October 31, 2011 by the Atmosphereic Imaging Assembly (AIA) on board the Solar Dynamic Observatory, the X-ray Telescope (XRT) and EUV Imaging Spectrometer (EIS) on board Hinode. We discuss the physical parameters of the jet that are obtained using imaging and spectroscopic observations, such as density, differential emission measure, peak temperature, velocity, and filling factor. Methods: A differential emission measure (DEM) analysis was performed at the region of the jet spire and the footpoint using EIS observations and also by combining AIA and XRT observations. The resulting EIS DEM curves were compared to those obtained with AIA-XRT. The DEM curves were used to create synthetic spectra with the CHIANTI atomic database. The predicted total count rates for each AIA channel were compared with the observed count rates. The effects of varying elemental abundances and the temperature range for the DEM inversion were investigated. Spectroscopic diagnostics were used to obtain an electron number density distribution for the jet spire and the jet footpoint. Results: The plasma along the line of sight in the jet spire and jet footpoint was found to be peak at 2.0 MK (log T [K] = 6.3). We calculated electron densities using the Fe XII (λ186/λ195) line ratio in the region of the spire (Ne = 7.6 × 1010 cm-3) and the footpoint (1.1 × 1011 cm-3). The plane-of-sky velocity of the jet is found to be 524 km s-1. The resulting EIS DEM values are in good agreement with those obtained from AIA-XRT. The synthetic spectra contributing to each AIA channel confirms the multi-thermal nature of the AIA channels in both regions. There is no indication of high temperatures, such as emission from Fe XVII (λ254.87) (log T [K] = 6.75) seen in the jet spire. In the case of the jet footpoint, synthetic spectra predict weak contributions from Ca XVII (λ192.85) and Fe XVII (λ254.87). With further investigation, we confirmed

  19. Luminescence of the disturbed upper atmosphere in the visible and infrared spectral ranges in the conditions of injection of a high-velocity plasma jet: II. Theoretical interpretation of the luminescence in the visible spectral range

    NASA Astrophysics Data System (ADS)

    Kozlov, S. I.; Smirnova, N. V.; Loseva, T. V.; Lyakhov, A. N.; Kosarev, I. B.

    2008-12-01

    A theoretical interpretation is given to the experimental data on the luminescence in the visible spectral region of the disturbed upper atmosphere in the conditions of injection of a high-velocity aluminum plasma jet (the “Fluxus” experiment). Mathematical models of optical effects are presented. It is demonstrated that the results of the calculations and the experimental data agree satisfactorily. The principal physical and chemical processes responsible for the observed luminescence are determined.

  20. W/Z+ jets and Z p_t measurements at Tevatron

    SciTech Connect

    Chung, Y.S.; /Rochester U.

    2006-10-01

    The authors present a measurement of W/Z boson + jets production and Z p{sub T} measurement in the p{bar p} collisions at the Tevatron Collider at {radical}s = 1.96 TeV. The CDF II measures W + jets production based on 320 pb{sup -1} and the D0 Run II measures Z + jets with 950 pb{sup -1} data. The measurement of Z p{sub T} is performed with D0 Run II data corresponding to an integrated luminosity of 960 pb{sup -1}. The measurement of W + jets is compared to the Leading Order Alpgen + Pythia prediction and the Z + jets is compared to Sherpa and Pythia Monte Carlo. The Z p{sub T} measurement is also compared to Resbos + Photos predictions.

  1. Specific heat of Teflon, Torlon 4203 and Torlon 4301 in the range of 30-400 mK

    NASA Astrophysics Data System (ADS)

    Singh, V.; Garai, A.; Mathimalar, S.; Dokania, N.; Nanal, V.; Pillay, R. G.; Ramakrishnan, S.

    2015-04-01

    The specific heat of amorphous polymers, Teflon, Torlon 4203 and Torlon 4301, has been measured in the range of 30-400 mK using thermal relaxation calorimetric technique. The data is consistent with the tunneling state models used to explain the observed unusual low temperature specific heat of amorphous polymers. Below 100 mK, the specific heat of Torlon 4301 is ∼3 times higher than that of Torlon 4203. Teflon has the lowest specific heat, ∼10 times lower than that of Torlon 4301.

  2. A study on L-asparaginase of Nocardia levis MK-VL_113.

    PubMed

    Kavitha, Alapati; Vijayalakshmi, Muvva

    2012-01-01

    An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized. Maximal yields of L-asparaginase were recorded from 3-day-old culture grown in modified asparagine-glycerol salts broth with initial pH 7.0 at temperature 30°C. Glycerol (2%) and yeast extract (1.5%) served as good carbon and nitrogen sources for L-asparaginase production, respectively. Cell-disrupting agents like EDTA slightly enhanced the productivity of L-asparaginase. Ours is the first paper on the production of L-asparaginase by N. levis.

  3. Digitalización de espectros fotográficos de standards MK

    NASA Astrophysics Data System (ADS)

    Corti, M.; Morrell, N.

    Se digitalizaron 70 espectros fotográficos de estrellas standards de clasificación MK con tipos espectrales comprendidos entre O3 y A2 y diferentes clases de luminosidad. Las observaciones utilizadas consisten en espectrogramas cuya dispersión recíproca es de 43 Å~mm-1, obtenidos con el telescopio de 1m de Cerro Tololo y su espectrógrafo Cassegrain, durante los años 1982 a 1985. Los trazados digitales se obtuvieron con el instrumento Grant de la Facultad de Ciencias Astronómicas y Geofísicas de La Plata y posteriormente fueron calibrados en longitud de onda y rectificados utilizando rutinas comprendidas dentro del paquete de procesamiento de imágenes IRAF. El material resultante puede utilizarse como ayuda para la clasificación de espectros obtenidos con similar configuración instrumental.

  4. Olfactory learning prevents MK-801-induced psychosis-like behaviour in an animal model of schizophrenia.

    PubMed

    Naimark, Ari; Barkai, Edi; Michael, Matar A; Kozlovsky, Nitzan; Kaplan, Zeev; Cohen, Hagit

    2008-01-01

    There is mounting evidence to support the concept that education is associated with the formation of a functional reserve in the brain, a process that appears to provide some protection against certain aspects of severe central nervous system disorders. The goal of this study was to examine whether learning prevents psychosis-like behaviour in an animal model of schizophrenia. A series of behavioural tasks were used to assess olfactory learning-induced protection against the effects of NMDA channel blocker, MK801. This blocker caused sensory-motor disturbances, spatial learning acquisition deficit, and swimming strategy alterations in pseudo-trained and naive rats, but had a considerably lesser effect on trained rats. In sharp contrast, olfactory learning provided no protection against d-amphetamine application. Our data support the notion that learning-induced protection against schizophrenic behaviour is maintained by non-NMDA-mediated enhanced activation of local connections in the relevant cortical networks.

  5. Josephson STM at mK temperatures: Coupling to the electronic environment

    NASA Astrophysics Data System (ADS)

    Dreyer, Michael; Dana, Rami; Liao, Wan-Ting; Lobb, Cris; Wellstood, Fred; Anderson, Bob

    Ultra-small Josephson junctions can couple to modes in the electronic environment. This leads to sub-gap peaks in the I(V) curve in addition to the phase diffuse supercurrent. The I(V) curve can - in principle - be explained by P(E) theory which describes the probability of tunneling at energy E. A recent study showed that antenna modes of the STM tips could be responsible for the observed sideband structures. In our case the explanation appears to be less simple. We employ a dual tip STM at a temperature of 30 mK. The I(V) spectra of the two tips show distinct patterns with only one shared mode. While the supercurrent branch for the ''inner'' tip is visible, it is obscured by a resonance for the ``outer'' tip. Possible causes and applications to other systems will be discussed. Support from NSF (DMR- 0605763) and Laboratory for Physical Sciences.

  6. Design and construction of high-sensitivity, infrared bolometers for operation at 300 mK

    NASA Technical Reports Server (NTRS)

    Alsop, D. C.; Inman, C.; Lange, A. E.; Wibanks, T.

    1992-01-01

    The design and construction of 300-mK composite bolometers developed for millimeter-wave astronomical observations are described. Graphite fibers are used as the electrical leads for the thermistor to reduce the thermal conductance and heat capacity associated with the leads. A mechanical suspension made of Nylon fibers provides the required thermal conductance. Electrical noise equivalent powers below 1 x 10 exp -16 W/sq rt Hz have been achieved for detectors with thermal time constants of 11 ms. The detectors were installed in a millimeter-wave photometer and used to perform observations of the cosmic microwave background from a balloonborne platform. The flight performance was consistent with the measured laboratory properties.

  7. [The Elektronika MK-52 programmable calculator in processing the results of biochemical studies].

    PubMed

    Dvorkin, V M

    1990-01-01

    The author reports the use of a new type of an Elektronika MK-52 programmed microcalculator for processing the results of biochemical studies. In contrast to other designs manufactured in this country, it is supplied with semifixed memory that permits storage of programs and data in the calculator after feeding switch off. Two new programs are suggested for estimating chorionic gonadotropin activity and for estimating liposome count in a preparation, and basic operations with the calculator are described as exemplified by these programs. The third program suggested by the author is intended for plotting various calibration straight lines; basing on this program the author demonstrates the use of memory enlargement units manufactured for this calculator.

  8. Enhanced control and sensing for the REMOTEC ANDROS Mk VI robot. CRADA final report

    SciTech Connect

    Spelt, P.F.; Harvey, H.W.

    1998-08-01

    This Cooperative Research and Development Agreement (CRADA) between Lockheed Martin Energy Systems, Inc., and REMOTEC, Inc., explored methods of providing operator feedback for various work actions of the ANDROS Mk VI teleoperated robot. In a hazardous environment, an extremely heavy workload seriously degrades the productivity of teleoperated robot operators. This CRADA involved the addition of computer power to the robot along with a variety of sensors and encoders to provide information about the robot`s performance in and relationship to its environment. Software was developed to integrate the sensor and encoder information and provide control input to the robot. ANDROS Mk VI robots are presently used by numerous electric utilities to perform tasks in reactors where substantial exposure to radiation exists, as well as in a variety of other hazardous environments. Further, this platform has potential for use in a number of environmental restoration tasks, such as site survey and detection of hazardous waste materials. The addition of sensors and encoders serves to make the robot easier to manage and permits tasks to be done more safely and inexpensively (due to time saved in the completion of complex remote tasks). Prior research on the automation of mobile platforms with manipulators at Oak Ridge National Laboratory`s Center for Engineering Systems Advanced Research (CESAR, B&R code KC0401030) Laboratory, a BES-supported facility, indicated that this type of enhancement is effective. This CRADA provided such enhancements to a successful working teleoperated robot for the first time. Performance of this CRADA used the CESAR laboratory facilities and expertise developed under BES funding.

  9. Enhanced control & sensing for the REMOTEC ANDROS Mk VI robot. Final report

    SciTech Connect

    Spelt, P.F.; Harvey, H.W.

    1997-08-01

    This Cooperative Research and Development Agreement (CRADA) between Lockheed Marietta Energy Systems, Inc., and REMOTEC, Inc., explored methods of providing operator feedback for various work actions of the ANDROS Mk VI teleoperated robot. In a hazardous environment, an extremely heavy workload seriously degrades the productivity of teleoperated robot operators. This CRADA involved the addition of computer power to the robot along with a variety of sensors and encoders to provide information about the robot`s performance in and relationship to its environment. Software was developed to integrate the sensor and encoder information and provide control input to the robot. ANDROS Mk VI robots are presently used by numerous electric utilities to perform tasks in reactors where substantial exposure to radiation exists, as well as in a variety of other hazardous environments. Further, this platform has potential for use in a number of environmental restoration tasks, such as site survey and detection of hazardous waste materials. The addition of sensors and encoders serves to make the robot easier to manage and permits tasks to be done more safely and inexpensively (due to time saved in the completion of complex remote tasks). Prior research on the automation of mobile platforms with manipulators at Oak Ridge National Laboratory`s Center for Engineering Systems Advanced Research (CESAR, B&R code KC0401030) Laboratory, a BES-supported facility, indicated that this type of enhancement is effective. This CRADA provided such enhancements to a successful working teleoperated robot for the first time. Performance of this CRADA used the CESAR laboratory facilities and expertise developed under BES funding.

  10. Scanning Tunneling Microscopy of Dirac Fermions at mK Temperatures

    NASA Astrophysics Data System (ADS)

    Stroscio, Joseph

    2011-03-01

    Since the beginning of the last century new frontiers in physics have emerged when advances in instrumentation achieved lower experimental operating temperatures. Notable examples include the discovery of superconductivity and the integer and fractional quantum Hall effects. New experimental techniques are continually adapted in order to meet new experimental challenges. A case in point is scanning tunneling microscopy (STM) which has seen a wealth of new measurements emerge as cryogenic STM instruments have been developed in the last two decades. In this talk I describe the design, development and performance of a scanning probe microscopy facility operating at a base temperature of 10 mK in magnetic fields up to 15 T. The microscope is cooled by a custom designed, fully ultra-high vacuum (UHV) compatible dilution refrigerator (DR) and is capable of in-situ tip and sample exchange. Sub-picometer stability at the tip-sample junction is achieved through three independent vibration isolation stages and careful design of the dilution refrigerator. The system can be connected to, or disconnected from, a network of interconnected auxiliary UHV chambers used for sample and probe tip preparation. Current measurements are focusing on Dirac fermions in graphene and in topological insulators. The history of the fractional quantum Hall states in semiconductor heterostructures suggests that studying graphene at lower temperatures and higher magnetic fields may reveal new quantum phases of matter. Scanning tunneling spectroscopy of graphene at mK temperatures reveals the detailed structure of the degenerate Landau levels in graphene, resolving the full quartet of states corresponding to the lifting of the spin and valley dengeneracies. When the Fermi level lies inside the four-fold Landau manifold, significant electron correlation effects result in enhanced valley splitting and spin splitting. New many-body states are observed at fractional filling factors of 7/2, 9/2, and 11/2.

  11. Models comparison for JET polarimeter data

    SciTech Connect

    Mazzotta, C.; Orsitto, F. P.; Giovannozzi, E.; Boboc, A.; Tudisco, O.; Zabeo, L.; Brombin, M.; Murari, A.

    2008-03-12

    A complete comparison between the theory and the measurements in polarimetry was done by using the Far Infrared Polarimeter at JET. More than 300 shots were analyzed, including a wide spectrum of JET scenarios in all critical conditions for polarimetry: high density, high and very low fields, high temperatures.This work is aimed at the demonstration of the robustness of the theoretical models for the JET polarimeter measurements in the perspective of using these models for ITER like plasma scenarios . In this context, an assessment was performed on how the line-integrated plasma density along the central vertical chord of FIR polarimeter could be evaluated using the Cotton-Mouton effect and its possible concrete use to correct fringe jumps of the interferometer.The models considered are: i) the rigorous numerical solution of the Stokes propagation equations, using dielectric tensor evaluated from JET equilibrium and Thomson scattering [1,2]; ii) two types of approximated solutions [2,3] and iii) the Guenther empirical model [4] that considers the mutual effect between Cotton-Mouton and Faraday rotation angle. The model calculations have been compared with polarimeter measurements for the Cotton-Mouton phase shift.The agreement with theory is satisfactory within the limits of experimental errors [3].

  12. Impulsively started incompressible turbulent jet

    SciTech Connect

    Witze, P O

    1980-10-01

    Hot-film anemometer measurements are presented for the centerline velocity of a suddenly started jet of air. The tip penetration of the jet is shown to be proportional to the square-root of time. A theoretical model is developed that assumes the transient jet can be characterized as a spherical vortex interacting with a steady-state jet. The model demonstrates that the ratio of nozzle radius to jet velocity defines a time constant that uniquely characterizes the behavior and similarity of impulsively started incompressible turbulent jets.

  13. Ram-jet Performance

    NASA Technical Reports Server (NTRS)

    Cervenko, A. J.; Friedman, R.

    1956-01-01

    The ram jet is basically one of the most dimple types of aircraft engine. It consists only of an inlet diffuser, a combustion system, and an exit nozzle. A typical ram-jet configuration is shown in figure 128. The engine operates on the Brayton cycle, and ideal cycle efficiency depends only on the ratio of engine to ambient pressure. The increased, engine pressures are obtained by ram action alone, and for this reason the ram jet has zero thrust at zero speed. Therefore, ram-jet-powered aircraft must be boosted to flight speeds close to a Mach number of 1.0 before appreciable thrust is generated by the engine. Since pressure increases are obtained by ram action alone, combustor-inlet pressures and temperatures are controlled by the flight speed, the ambient atmospheric condition, and by the efficiency of the inlet diffuser. These pressures and temperatures, as functions of flight speed and altitude, are shown in figure 129 for the NACA standard atmosphere and for practical values of diffuser efficiency. It can be seen that very wide ranges of combustor-inlet temperatures and pressures may be encountered over the ranges of flight velocity and altitude at which ram jets may be operated. Combustor-inlet temperatures from 500 degrees to 1500 degrees R and inlet pressures from 5 to 100 pounds per square inch absolute represent the approximate ranges of interest in current combustor development work. Since the ram jet has no moving parts in the combustor outlet, higher exhaust-gas temperatures than those used in current turbojets are permissible. Therefore, fuel-air ratios equivalent to maximum rates of air specific impulse or heat release can be used, and, for hydrocarbon fuels, this weight ratio is about 0.070. Lower fuel-air ratios down to about 0.015 may also be required to permit efficient cruise operation. This fuel-air-ratio range of 0.015 to 0.070 used in ram jets can be compared with the fuel-air ratios up to 0.025 encountered in current turbojets. Ram-jet

  14. MTAD Demonstration Data Report Former Camp San Luis Obispo Magnetometer and EM61 MkII Surveys

    DTIC Science & Technology

    2010-05-01

    The site is shown as a series of included 30m x 30m cells . See the text for further discussion... cells with a topographical map as the background. The cells are color-coded based on the data collection systems that collected data on them, tan...L9 L7 K5 K8 K4 K7 K6 K9 N8 N9 N6 N7 P9 I11 O9 O8 M7 M9 M8 M6 M5 I10 I12 J12 J13 F11 L14 L15 L13 F10 N11H11 K13 K14 O11G11 P11 N10H10 N13 N12 O12 G10

  15. The M87 Jet. "Rosetta Stone" of AGN Jets

    NASA Astrophysics Data System (ADS)

    Nakamura, Masanori; Asada, Keiichi

    2013-12-01

    We investigate the structure and dynamics of the M87 jet based on multi-frequency VLBI observations and MHD jet theories. Millimeter VLBI cores are considered as innermost jet emissions. The jet structure up to ~ 105 rs is described as a parabolic streamline, indicating the lateral expansion under a confinement by the stratified ISM. Thus, the jet collimation maintains in five orders of magnitude in the distance starting from the vicinity of the supermassive black hole (SMBH), less than 10 rs. We here examine the jet parabolic structure in order to identify the property of a bulk acceleration; observed sub-to-superluminal motions indicate an MHD acceleration from non-relativistic to relativistic regimes. We propose that the M87 jet consists of Poynting-flux dominated flows, powered by nonlinear torsional Alfvén waves. Future sub-mm VLBI observations play an important role in resolving the origin of the M87 jets.

  16. B-jets and z + b-jets at CDF

    SciTech Connect

    Jeans, Daniel; /Rome U.

    2006-06-01

    The authors present CDF cross-section measurements for the inclusive production of b jets and the production of b jets in association with a Z{sup 0} boson. Both measurements are in reasonable agreement with NLO QCD predictions.

  17. The Twin Jet Nebula

    NASA Technical Reports Server (NTRS)

    1997-01-01

    M2-9 is a striking example of a 'butterfly' or a bipolar planetary nebula. Another more revealing name might be the 'Twin Jet Nebula.' If the nebula is sliced across the star, each side of it appears much like a pair of exhausts from jet engines. Indeed, because of the nebula's shape and the measured velocity of the gas, in excess of 200 miles per second, astronomers believe that the description as a super-super-sonic jet exhaust is quite apt. This is much the same process that takes place in a jet engine: The burning and expanding gases are deflected by the engine walls through a nozzle to form long, collimated jets of hot air at high speeds. M2-9 is 2,100 light-years away in the constellation Ophiucus. The observation was taken Aug. 2, 1997 by the Hubble telescope's Wide Field and Planetary Camera 2. In this image, neutral oxygen is shown in red, once-ionized nitrogen in green, and twice-ionized oxygen in blue.

  18. Jet propulsion without inertia

    NASA Astrophysics Data System (ADS)

    Spagnolie, Saverio E.; Lauga, Eric

    2010-08-01

    A body immersed in a highly viscous fluid can locomote by drawing in and expelling fluid through pores at its surface. We consider this mechanism of jet propulsion without inertia in the case of spheroidal bodies and derive both the swimming velocity and the hydrodynamic efficiency. Elementary examples are presented and exact axisymmetric solutions for spherical, prolate spheroidal, and oblate spheroidal body shapes are provided. In each case, entirely and partially porous (i.e., jetting) surfaces are considered and the optimal jetting flow profiles at the surface for maximizing the hydrodynamic efficiency are determined computationally. The maximal efficiency which may be achieved by a sphere using such jet propulsion is 12.5%, a significant improvement upon traditional flagella-based means of locomotion at zero Reynolds number, which corresponds to the potential flow created by a source dipole at the sphere center. Unlike other swimming mechanisms which rely on the presentation of a small cross section in the direction of motion, the efficiency of a jetting body at low Reynolds number increases as the body becomes more oblate and limits to approximately 162% in the case of a flat plate swimming along its axis of symmetry. Our results are discussed in the light of slime extrusion mechanisms occurring in many cyanobacteria.

  19. Jet engine testing apparatus

    SciTech Connect

    Zweifel, T.L.

    1987-03-24

    An apparatus is described for testing jet engines mounted on an aircraft, the jet engines of the type having a high speed rotor and a low speed rotor, comprising: representative signal means for providing first representative signals representative of rotation rates of the low speed rotor in the jet engines and second representative signals representative of rotation rates of the high speed rotor in the jet engines; equivalent signal means coupled to receive the second representative signals for deriving equivalent signals representative of low speed rotor rotation rates of normally operating jet engines having high speed rotor rotation rates represented by the second representative signals; first difference signal means coupled to receive the first representative signals and the equivalent signals for providing first difference signals representative of differences between the first representative signals and the equivalent signals; means for providing threshold signals; first detector means coupled to the threshold signal means and the first difference signal means for comparing the threshold signals and the first difference signals to provide first detected signals representative of values of the first difference signals relative to the threshold signals; and engine failure indicator means coupled to receive the detected signals for determination of engine failures.

  20. Sweeping Jet Optimization Studies

    NASA Technical Reports Server (NTRS)

    Melton, LaTunia Pack; Koklu, Mehti; Andino, Marlyn; Lin, John C.; Edelman, Louis

    2016-01-01

    Progress on experimental efforts to optimize sweeping jet actuators for active flow control (AFC) applications with large adverse pressure gradients is reported. Three sweeping jet actuator configurations, with the same orifice size but di?erent internal geometries, were installed on the flap shoulder of an unswept, NACA 0015 semi-span wing to investigate how the output produced by a sweeping jet interacts with the separated flow and the mechanisms by which the flow separation is controlled. For this experiment, the flow separation was generated by deflecting the wing's 30% chord trailing edge flap to produce an adverse pressure gradient. Steady and unsteady pressure data, Particle Image Velocimetry data, and force and moment data were acquired to assess the performance of the three actuator configurations. The actuator with the largest jet deflection angle, at the pressure ratios investigated, was the most efficient at controlling flow separation on the flap of the model. Oil flow visualization studies revealed that the flow field controlled by the sweeping jets was more three-dimensional than expected. The results presented also show that the actuator spacing was appropriate for the pressure ratios examined.

  1. Gamma-ray burst jets: uniform or structured?

    NASA Astrophysics Data System (ADS)

    Salafia, O. S.; Pescalli, A.; Nappo, F.; Ghisellini, G.; Ghirlanda, G.; Salvaterra, R.; Tagliaferri, G.

    The structure of Gamma-Ray Burst (GRB) jets impacts on their prompt and afterglow emission properties. Insights into the still unknown structure of GRBs can be achieved by studying how different structures impact on the luminosity function (LF): i) we show that low ($10^{46} < L_{\\rm iso} < 10^{48}$ erg/s) and high (i.e. with $L_{\\rm iso} > 10^{50}$ erg/s) luminosity GRBs can be described by a unique LF; ii) we find that a uniform jet (seen on- and off-axis) as well as a very steep structured jet (i.e. $\\epsilon(\\theta) \\propto \\theta^{-s}$ with $s > 4$) can reproduce the current LF data; iii) taking into account the emission from the whole jet (i.e. including contributions from mildly relativistic, off-axis jet elements) we find that $E_{\\rm iso}(\\theta_{\\rm v})$ (we dub this quantity "apparent structure") can be very different from the intrinsic structure $\\epsilon(\\theta)$: in particular, a jet with a Gaussian intrinsic structure has an apparent structure which is more similar to a power law. This opens a new viewpoint on the quasi-universal structured jet hypothesis.

  2. Study of the heavy flavour fractions in z+jets events from $p\\bar{p}$ collisions at energy √s = 1.96 TeV with the CDF II detector at the Tevatron collider

    SciTech Connect

    Mastrandrea, Paolo

    2008-06-01

    to provide collisions for the experiments at the end of 2008. In the meanwhile the only running accelerator able to provide collisions suitable for the search of the Higgs boson is the Tevatron at Fermilab, a proton-antiproton collider with a center of mass energy of 1.96 TeV working at 3 • 1032cm-2s-1 peak luminosity. These features make the Tevatron able for the direct search of the Higgs boson in the 115-200 GeV mass range. Since the coupling of the Higgs boson is proportional to the masses of the particles involved, the decay in b{bar b} has the largest branching ratio for Higgs mass < 135 GeV and thus the events Z/W + $b\\bar{b}$ are the main background to the Higgs signal in the most range favored by Standard Model fits. In this thesis a new technique to identify Heavy Flavour quarks inside high - PT jets is applied to events with a reconstructed Z boson to provide a measurement of the Z+b and Z+c inclusive cross sections. The study of these channels represent also a test of QCD in high transferred momentum regime, and can provide information on proton pdf. This new Heavy Flavour identication technique (tagger) provides an increased statistical separation between b, c and light flavours, using a new vertexing algorithm and a chain of artificial Neural Networks to exploit as much information as possible in each event. For this work I collaborated with the Universita di Roma 'La Sapienza' group working in the CDF II experiment at Tevatron, that has at first developed this tagger. After a brief theoretical introduction (chapter 1) and a description of the experimental apparatus (chapter 2), the tagger itself and its calibration procedure are described in chapter 3 and 4. The chapter 5 is dedicated to the event selection and the chapter 6 contains the results of the measurement and the study of the systematic errors.

  3. Aeroacoustic Experiments with Twin Jets

    NASA Technical Reports Server (NTRS)

    Bozak, Richard F.; Henderson, Brenda S.

    2012-01-01

    While the noise produced by a single jet is azimuthally symmetric, multiple jets produce azimuthally varying far-field noise. The ability of one jet to shield another reduces the noise radiated in the plane of the jets, while often increasing the noise radiated out of the plane containing the jets. The present study investigates the shielding potential of twin jet configurations over subsonic and over-expanded supersonic jet conditions with simulated forward flight. The experiments were conducted with 2 in. throat diameter nozzles at four jet spacings from 2.6d to 5.5d in center-to-center distance, where d is the nozzle throat diameter. The current study found a maximum of 3 dB reduction in overall sound pressure level relative to two incoherent jets in the peak jet noise direction in the plane containing the jets. However, an increase of 3 dB was found perpendicular to the plane containing the jets. In the sideline direction, shielding is observed for all jet spacings in this study.

  4. Helical magnetic field models for parsec-scale radio jets

    NASA Astrophysics Data System (ADS)

    Papageorgiou, A.

    2006-10-01

    Total intensity and polarization structure of extragalactic radio jets are presented in support of models that jets are threaded by helical magnetic fields. Helical magnetic field models predict the following features i) asymmetric distribution in both or either the total and polarized intensity across the jet, ii)displacement between the maxima of total and polarized intensity distributions, iii) abrupt rotation (90 degrees) of the magnetic field position angle (MVPA) and iv) edge brightening in polarization and total intensity. VLBI observations of parsec-scale jets are presented, showing examples of the above predicted features; in one case all four predicted features are present in one source (1055+018).%T GPS studies during the ENIGMA era

  5. Anomalous nonlinear attenuation of ultrasound in solid 4He in a torsional oscillator below 200 mK

    NASA Astrophysics Data System (ADS)

    Iwasa, I.; Goodkind, J. M.; Kojima, H.

    2014-12-01

    In order to elucidate the ultra-low temperature behavior of solid 4He, simultaneous measurements of longitudinal ultrasound (US) and torsional oscillation have been made. Changes in attenuation and velocity of US at 10 MHz have been measured in polycrystalline hcp 4He samples (0.3 or 20 ppm of 3He impurity) grown in a 1 kHz torsional oscillator (TO). In a 0.3 ppm 3He sample, the US attenuation and velocity were found to depend on the US drive voltage at temperatures below 70 mK where the anomalies in the TO frequency and dissipation were also observed. The US attenuation at low T (10 mK) decreased monotonically as the drive voltage was decreased but then remained small and constant as the drive voltage was increased again. The US velocity change at low T was negative with respect to the high-T (400 mK) value, contrary to the positive sign expected from the known variation in the shear modulus. In a 20 ppm 3He sample, both the US and TO anomalies shifted to 150 mK. The amplitude dependence and hysteresis of US attenuation were related to pinning of dislocations by 3He impurities, and nonlinear spatial variations of the amplitude of US pulses were derived.

  6. Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex

    PubMed Central

    Ji, Shuang; Lin, Wei; Wang, Li; Ni, Zhaofei; Jin, Fuquan; Zha, Xiaojun; Fei, Guanghe

    2017-01-01

    Tuberous sclerosis complex (TSC), caused by loss-of-function mutations in the TSC1 or TSC2 genes, is an autosomal dominant disease characterized by benign tumor formation in multiple organs. Hyperactivation of mammalian target of rapamycin (mTOR) is the primary alteration underlying TSC tumor. Thus, rapamycin, as an mTOR specific inhibitor, has been assumed as a potential drug for the treatment of TSC. However, its application in TSC patients has been limited due to side effects. By analyzing Tsc1- or Tsc2-null mouse embryonic fibroblasts (MEFs), we found that loss of TSC1 or TSC2 led to a decreased sensitivity to MK-2206, a novel allosteric Akt inhibitor. Ectopic expression of a constitutively activated Akt (myristoylated Akt-1, myrAkt-1) sensitized Tsc2-null and Tsc1-null MEFs to MK-2206. Furthermore, MK-2206 increased the cytotoxicity of rapamycin in Tsc1-/-or Tsc2-/- MEFs. Moreover, the benefit of the combinatorial treatment was also demonstrated in a TSC xenograft mouse model. We conclude that the combination of rapamycin and MK-2206 may be utilized as a new therapeutic regimen for TSC. PMID:28367235

  7. A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults with ADHD

    ERIC Educational Resources Information Center

    Rivkin, Anna; Alexander, Robert C.; Knighton, Jennifer; Hutson, Pete H.; Wang, Xiaojing J.; Snavely, Duane B.; Rosah, Thomas; Watt, Alan P.; Reimherr, Fred W.; Adler, Lenard A.

    2012-01-01

    Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted…

  8. Measurement of b-jet shapes in inclusive jet production in p pmacr collisions at s=1.96TeV

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Akimoto, T.; Albrow, M. G.; González, B. Álvarez; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Azzurri, P.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Bartsch, V.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Bednar, P.; Beecher, D.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Beringer, J.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bolla, G.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Calancha, C.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Choudalakis, G.; Chuang, S. H.; Chung, K.; Chung, W. H.; Chung, Y. S.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Copic, K.; Cordelli, M.; Cortiana, G.; Cox, D. J.; Crescioli, F.; Almenar, C. Cuenca; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lorenzo, G.; Dell'Orso, M.; Deluca, C.; Demortier, L.; Deng, J.; Deninno, M.; Derwent, P. F.; di Giovanni, G. P.; Dionisi, C.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Donini, J.; Dorigo, T.; Dube, S.; Efron, J.; Elagin, A.; Erbacher, R.; Errede, D.; Errede, S.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Genser, K.; Gerberich, H.; Gerdes, D.; Gessler, A.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; da Costa, J. Guimaraes; Gunay-Unalan, Z.; Haber, C.; Hahn, K.; Hahn, S. R.; Halkiadakis, E.; Han, B.-Y.; Han, J. Y.; Handler, R.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harper, S.; Harr, R. F.; Harris, R. M.; Hartz, M.; Hatakeyama, K.; Hauser, J.; Hays, C.; Heck, M.; Heijboer, A.; Heinemann, B.; Heinrich, J.; Henderson, C.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Huffman, B. T.; Hughes, R. E.; Husemann, U.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jayatilaka, B.; Jeon, E. J.; Jha, M. K.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Knuteson, B.; Ko, B. R.; Koay, S. A.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kubo, T.; Kuhr, T.; Kulkarni, N. P.; Kurata, M.; Kusakabe, Y.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, E.; Lee, S. W.; Leone, S.; Lewis, J. D.; Lin, C. S.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, T.; Lockyer, N. S.; Loginov, A.; Loreti, M.; Lovas, L.; Lu, R.-S.; Lucchesi, D.; Lueck, J.; Luci, C.; Lujan, P.; Lukens, P.; Lungu, G.; Lyons, L.; Lys, J.; Lysak, R.; Lytken, E.; Mack, P.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maki, T.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Maruyama, T.; Mastrandrea, P.; Masubuchi, T.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzione, A.; Merkel, P.; Mesropian, C.; Miao, T.; Miladinovic, N.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlok, J.; Fernandez, P. Movilla; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Mumford, R.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Nagano, A.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Necula, V.; Neu, C.; Neubauer, M. S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Osterberg, K.; Griso, S. Pagan; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramonov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Poukhov, O.; Pounder, N.; Prakoshyn, F.; Pronko, A.; Proudfoot, J.; Ptohos, F.; Pueschel, E.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Reisert, B.; Rekovic, V.; Renton, P.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Saltó, O.; Santi, L.; Sarkar, S.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Scheidle, T.; Schlabach, P.; Schmidt, A.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scott, A. L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sfyrla, A.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Sherman, D.; Shimojima, M.; Shiraishi, S.; Shochet, M.; Shon, Y.; Shreyber, I.; Sidoti, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soha, A.; Somalwar, S.; Sorin, V.; Spalding, J.; Spreitzer, T.; Squillacioti, P.; Stanitzki, M.; Denis, R. St.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Stuart, D.; Suh, J. S.; Sukhanov, A.; Suslov, I.; Suzuki, T.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tecchio, M.; Teng, P. K.; Terashi, K.; Thom, J.; Thompson, A. S.; Thompson, G. A.; Thomson, E.; Tipton, P.; Tiwari, V.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Tourneur, S.; Tu, Y.; Turini, N.; Ukegawa, F.; Vallecorsa, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Veszpremi, V.; Vidal, M.; Vidal, R.; Vila, I.; Vilar, R.; Vine, T.; Vogel, M.; Volobouev, I.; Volpi, G.; Würthwein, F.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner-Kuhr, J.; Wagner, W.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wright, T.; Wu, X.; Wynne, S. M.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanello, L.; Zanetti, A.; Zaw, I.; Zhang, X.; Zheng, Y.; Zucchelli, S.

    2008-10-01

    We present a measurement of the shapes of b-jets using 300pb-1 of data obtained with the upgraded Collider Detector at Fermilab (CDF II) in p pmacr collisions at center-of-mass energy s=1.96TeV. This measurement covers a wide transverse momentum range, from 52 to 300GeV/c. Samples of heavy-flavor enhanced jets together with inclusive jets are used to extract the average shapes of b-jets. The b-jets are expected to be broader than inclusive jets. Moreover, b-jets containing a single b-quark are expected to be narrower than those containing a b bmacr pair from gluon splitting. The measured b-jet shapes are found to be significantly broader than expected from the pythia and herwig Monte Carlo simulations. This effect may arise from an underestimation of the fraction of b-jets originating from gluon splitting in these simulations. The jet shape distributions provided in this paper could be compared to any full Monte Carlo simulation and could be used to further constrain the various parameters.

  9. Renewable jet fuel.

    PubMed

    Kallio, Pauli; Pásztor, András; Akhtar, M Kalim; Jones, Patrik R

    2014-04-01

    Novel strategies for sustainable replacement of finite fossil fuels are intensely pursued in fundamental research, applied science and industry. In the case of jet fuels used in gas-turbine engine aircrafts, the production and use of synthetic bio-derived kerosenes are advancing rapidly. Microbial biotechnology could potentially also be used to complement the renewable production of jet fuel, as demonstrated by the production of bioethanol and biodiesel for piston engine vehicles. Engineered microbial biosynthesis of medium chain length alkanes, which constitute the major fraction of petroleum-based jet fuels, was recently demonstrated. Although efficiencies currently are far from that needed for commercial application, this discovery has spurred research towards future production platforms using both fermentative and direct photobiological routes.

  10. Measurement of inclusive jet cross sections in Z/gamma*(-->e+e-) + jets production in pp[over ] collisions at square root s = 1.96 TeV.

    PubMed

    Aaltonen, T; Adelman, J; Akimoto, T; Albrow, M G; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'orso, M; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopolou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R-S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, S Z; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S

    2008-03-14

    Inclusive jet cross sections in Z/gamma* events, with Z/gamma* decaying into an electron-positron pair, are measured as a function of jet transverse momentum and jet multiplicity in pp[over ] collisions at square root s = 1.96 TeV with the upgraded Collider Detector at Fermilab in run II, based on an integrated luminosity of 1.7 fb(-1). The measurements cover the rapidity region |y(jet)|<2.1 and the transverse momentum range p(T)(jet)>30 GeV/c. Next-to-leading order perturbative QCD predictions are in good agreement with the measured cross sections.

  11. Jet Shockwaves Produce Gamma Rays

    NASA Video Gallery

    Theorists believe that GRB jets produce gamma rays by two processes involving shock waves. Shells of material within the jet move at different speeds and collide, generating internal shock waves th...

  12. Resolving boosted jets with XCone

    NASA Astrophysics Data System (ADS)

    Thaler, Jesse; Wilkason, Thomas F.

    2015-12-01

    We show how the recently proposed XCone jet algorithm [1] smoothly interpolates between resolved and boosted kinematics. When using standard jet algorithms to reconstruct the decays of hadronic resonances like top quarks and Higgs bosons, one typically needs separate analysis strategies to handle the resolved regime of well-separated jets and the boosted regime of fat jets with substructure. XCone, by contrast, is an exclusive cone jet algorithm that always returns a fixed number of jets, so jet regions remain resolved even when (sub)jets are overlapping in the boosted regime. In this paper, we perform three LHC case studies — dijet resonances, Higgs decays to bottom quarks, and all-hadronic top pairs — that demonstrate the physics applications of XCone over a wide kinematic range.

  13. Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801.

    PubMed

    Bygrave, A M; Masiulis, S; Nicholson, E; Berkemann, M; Barkus, C; Sprengel, R; Harrison, P J; Kullmann, D M; Bannerman, D M; Kätzel, D

    2016-04-12

    It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come from examination of genetically modified mice where the obligatory NMDAR-subunit GluN1 (also known as NR1) has been deleted from PV interneurons by Cre-mediated knockout of the corresponding gene Grin1 (Grin1(ΔPV) mice). Notably, such PV-specific GluN1 ablation has been reported to blunt the induction of hyperlocomotion (a surrogate for psychosis) by pharmacological NMDAR blockade with the non-competitive antagonist MK-801. This suggests PV-NMDARs as the site of the psychosis-inducing action of MK-801. In contrast to this hypothesis, we show here that Grin1(ΔPV) mice are not protected against the effects of MK-801, but are in fact sensitized to many of them. Compared with control animals, Grin1(ΔPV)mice injected with MK-801 show increased stereotypy and pronounced catalepsy, which confound the locomotor readout. Furthermore, in Grin1(ΔPV)mice, MK-801 induced medial-prefrontal delta (4 Hz) oscillations, and impaired performance on tests of motor coordination, working memory and sucrose preference, even at lower doses than in wild-type controls. We also found that untreated Grin1(ΔPV)mice are largely normal across a wide range of cognitive functions, including attention, cognitive flexibility and various forms of short-term memory. Taken together these results argue against PV-specific NMDAR hypofunction as a key starting point of schizophrenia pathophysiology, but support a model where NMDAR hypofunction in multiple cell types contribute to the disease.

  14. Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801

    PubMed Central

    Bygrave, A M; Masiulis, S; Nicholson, E; Berkemann, M; Barkus, C; Sprengel, R; Harrison, P J; Kullmann, D M; Bannerman, D M; Kätzel, D

    2016-01-01

    It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come from examination of genetically modified mice where the obligatory NMDAR-subunit GluN1 (also known as NR1) has been deleted from PV interneurons by Cre-mediated knockout of the corresponding gene Grin1 (Grin1ΔPV mice). Notably, such PV-specific GluN1 ablation has been reported to blunt the induction of hyperlocomotion (a surrogate for psychosis) by pharmacological NMDAR blockade with the non-competitive antagonist MK-801. This suggests PV-NMDARs as the site of the psychosis-inducing action of MK-801. In contrast to this hypothesis, we show here that Grin1ΔPV mice are not protected against the effects of MK-801, but are in fact sensitized to many of them. Compared with control animals, Grin1ΔPVmice injected with MK-801 show increased stereotypy and pronounced catalepsy, which confound the locomotor readout. Furthermore, in Grin1ΔPVmice, MK-801 induced medial-prefrontal delta (4 Hz) oscillations, and impaired performance on tests of motor coordination, working memory and sucrose preference, even at lower doses than in wild-type controls. We also found that untreated Grin1ΔPVmice are largely normal across a wide range of cognitive functions, including attention, cognitive flexibility and various forms of short-term memory. Taken together these results argue against PV-specific NMDAR hypofunction as a key starting point of schizophrenia pathophysiology, but support a model where NMDAR hypofunction in multiple cell types contribute to the disease. PMID:27070406

  15. Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men.

    PubMed

    Rittmaster, R S; Stoner, E; Thompson, D L; Nance, D; Lasseter, K C

    1989-01-01

    To determine the hormonal effects of MK-906, an orally active 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates, 12 healthy men were given 10, 20, 50, and 100 mg MK-906 2 weeks apart in randomized order in a 4-period crossover design. Serum testosterone (T), dihydrotestosterone (DHT), androstanediol glucuronide, and androsterone glucuronide were measured before and 24 hours after each dose. The effect of MK-906 on glucuronyl transferase activity, the enzyme responsible for androstanediol glucuronide and androsterone glucuronide formation, was assessed in vitro using rat prostate tissue. Serum T levels were unchanged after all doses. Serum DHT, androstanediol glucuronide, and androsterone glucuronide were suppressed by 70, 40, and 56%, respectively, after the 10-mg dose, and by 82, 52, and 66% after the 100-mg dose (P less than 0.02 for the comparison between the 10 and 100-mg doses for all three steroids), respectively. Baseline serum T and DHT levels were strongly correlated (R = 0.89, P = 0.0002), as were androstanediol glucuronide and androsterone glucuronide levels (R = 0.78, P = 0.003), but there was no correlation between DHT levels and the levels of either conjugated steroid. MK-906 had no effect on glucuronyl transferase activity in vitro. It was concluded that single doses of MK-906 suppress both conjugated and unconjugated 5 alpha-reduced androgens. While all three steroids appeared to be good markers of systemic 5 alpha-reductase inhibition, further research will be needed to determine which steroid best reflects tissue DHT levels in patients receiving these inhibitors.

  16. Jet pump assisted artery

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A procedure for priming an arterial heat pump is reported; the procedure also has a means for maintaining the pump in a primed state. This concept utilizes a capillary driven jet pump to create the necessary suction to fill the artery. Basically, the jet pump consists of a venturi or nozzle-diffuser type constriction in the vapor passage. The throat of this venturi is connected to the artery. Thus vapor, gas, liquid, or a combination of the above is pumped continuously out of the artery. As a result, the artery is always filled with liquid and an adequate supply of working fluid is provided to the evaporator of the heat pipe.

  17. Control of Asymmetric Jet

    DTIC Science & Technology

    1992-06-30

    with 5hciir Irycr frequencies arnd miodfy th-e preferied mode. Perforte~d steel plateCs "-leed with tempcratuze-resistatr: mnsulativ- mineral wool reduce...Insulation of the Jet facility was initially ... ovid. d 6y ibuiglass, then mineral wool and at the present there is none for health concerns. The...imerior of the jet’s anechoic chamber was also insulated with mineral wool to foitify acoustic damping, however this too has been removed due to portions

  18. Multiwavelength study of 20 jets that emanate from the periphery of active regions

    NASA Astrophysics Data System (ADS)

    Mulay, Sargam M.; Tripathi, Durgesh; Del Zanna, Giulio; Mason, Helen

    2016-05-01

    T [K] = 6.2/6.3 (~2 MK). In addition, we derived an emission measure and a lower limit of electron density at the location of the spire (jet 1: log EM = 28.6, Ne = 1.3 × 1010 cm-3; jet 2: log EM = 28.0, Ne = 8.6 × 109 cm-3) and the footpoint (jet 1 - log EM = 28.6, Ne = 1.1 × 1010 cm-3; jet 2: log EM = 28.1, Ne = 8.4 × 109 cm-3). These results are in agreement with those obtained earlier by studying individual active region jets. Conclusions: The observation of flux cancellation, the association with HXR emission and emission of nonthermal type-III radio bursts, suggest that the initiation and therefore, heating is taking place at the base of the jet. This is also supported by the high temperature plasma revealed by the DEM analysis in the jet footpoint (peak in the DEM at log T [K] = 6.5). Our results provide substantial constraints for theoretical modeling of the jets and their thermodynamic nature. Movies are available in electronic form at http://www.aanda.org

  19. Cooperative Investigation of Jet Flows.

    DTIC Science & Technology

    1982-06-01

    high and low Reynolds number jets. Controlling the jet with pure tone excitation, that enhances the helical mode of its instability, resulted in a... helical modes and upstream influence appear to be key mechanisms in our findings 3.- -- - Disatributio~n/ Availit- UNCLASSIFIED 89CUMIIY CLAWIPCAT OF...and low Reynolds number*’ jets. Controlling the jet with pure tone excitation, that enhances the helical mode of its instability, resulted in a

  20. 'Photonic jets' from dielectric microaxicons

    SciTech Connect

    Geints, Yu E; Zemlyanov, A A; Panina, E K

    2015-08-31

    We consider a specific spatially localised light structure, namely, a 'photonic jet' formed in the near field upon scattering of an optical wave in a dielectric micron particle. Dimensional parameters and intensity of a photonic jet from microaxicons of different spatial orientation are studied theoretically. It is found for the first time that an axicon-generated photonic jet has in this case a substantially larger length compared with the case of a jet formed on a spherical particle. (scattering of light)

  1. MULTIPLE PLASMA EJECTIONS AND INTERMITTENT NATURE OF MAGNETIC RECONNECTION IN SOLAR CHROMOSPHERIC ANEMONE JETS

    SciTech Connect

    Singh, K. A. P.; Nishida, K.; Shibata, K.; Isobe, H.; Nishizuka, N. E-mail: nishida@kwasan.kyoto-u.ac.jp E-mail: isobe@kwasan.kyoto-u.ac.jp

    2012-11-01

    The recent discovery of chromospheric anemone jets with the Solar Optical Telescope (SOT) on board Hinode has shown an indirect evidence of magnetic reconnection in the solar chromosphere. However, the basic nature of magnetic reconnection in chromosphere is still unclear. We studied nine chromospheric anemone jets from SOT/Hinode using Ca II H filtergrams, and we found multiple bright, plasma ejections along the jets. In most cases, the major intensity enhancements (larger than 30% relative to the background intensity) of the loop correspond to the timing of the plasma ejections. The typical lifetime and size of the plasma ejecta are about 20-60 s and 0.3-1.5 Mm, respectively. The height-time plot of jet shows many sub-structures (or individual jets) and the typical lifetime of the individual jet is about one to five minutes. Before the onset of the jet activity, a loop appears in Ca II H and gradually increases in size, and after few minutes several jets are launched from the loop. Once the jet activity starts and several individual jets are launched, the loop starts shrinking with a speed of {approx}4 km s{sup -1}. In some events, a downward moving blob with a speed of {approx}35 km s{sup -1} was observed, associated with the upward moving plasma along one of the legs of the loop hosting the jets. The upward moving plasma gradually developed into jets. Multiple plasma ejections in chromospheric anemone jet show the strongly time-dependent as well as intermittent nature of magnetic reconnection in the solar chromosphere.

  2. Magnetic Untwisting in Solar Jets that Go into the Outer Corona in Polar Coronal Holes

    NASA Astrophysics Data System (ADS)

    Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.

    2015-06-01

    We study 14 large solar jets observed in polar coronal holes. In EUV movies from the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA), each jet appears similar to most X-ray jets and EUV jets that erupt in coronal holes; but each is exceptional in that it goes higher than most, so high that it is observed in the outer corona beyond 2.2 R Sun in images from the Solar and Heliospheric Observatory/Large Angle Spectroscopic Coronagraph (LASCO)/C2 coronagraph. From AIA He ii 304 Å movies and LASCO/C2 running-difference images of these high-reaching jets, we find: (1) the front of the jet transits the corona below 2.2 R Sun at a speed typically several times the sound speed; (2) each jet displays an exceptionally large amount of spin as it erupts; (3) in the outer corona, most of the jets display measureable swaying and bending of a few degrees in amplitude; in three jets the swaying is discernibly oscillatory with a period of order 1 hr. These characteristics suggest that the driver in these jets is a magnetic-untwisting wave that is basically a large-amplitude (i.e., nonlinear) torsional Alfvén wave that is put into the reconnected open field in the jet by interchange reconnection as the jet erupts. From the measured spinning and swaying, we estimate that the magnetic-untwisting wave loses most of its energy in the inner corona below 2.2 R Sun. We point out that the torsional waves observed in Type-II spicules might dissipate in the corona in the same way as the magnetic-untwisting waves in our big jets, and thereby power much of the coronal heating in coronal holes.

  3. MAGNETIC UNTWISTING IN SOLAR JETS THAT GO INTO THE OUTER CORONA IN POLAR CORONAL HOLES

    SciTech Connect

    Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.

    2015-06-10

    We study 14 large solar jets observed in polar coronal holes. In EUV movies from the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA), each jet appears similar to most X-ray jets and EUV jets that erupt in coronal holes; but each is exceptional in that it goes higher than most, so high that it is observed in the outer corona beyond 2.2 R{sub Sun} in images from the Solar and Heliospheric Observatory/Large Angle Spectroscopic Coronagraph (LASCO)/C2 coronagraph. From AIA He ii 304 Å movies and LASCO/C2 running-difference images of these high-reaching jets, we find: (1) the front of the jet transits the corona below 2.2 R{sub Sun} at a speed typically several times the sound speed; (2) each jet displays an exceptionally large amount of spin as it erupts; (3) in the outer corona, most of the jets display measureable swaying and bending of a few degrees in amplitude; in three jets the swaying is discernibly oscillatory with a period of order 1 hr. These characteristics suggest that the driver in these jets is a magnetic-untwisting wave that is basically a large-amplitude (i.e., nonlinear) torsional Alfvén wave that is put into the reconnected open field in the jet by interchange reconnection as the jet erupts. From the measured spinning and swaying, we estimate that the magnetic-untwisting wave loses most of its energy in the inner corona below 2.2 R{sub Sun}. We point out that the torsional waves observed in Type-II spicules might dissipate in the corona in the same way as the magnetic-untwisting waves in our big jets, and thereby power much of the coronal heating in coronal holes.

  4. Laboratory-produced MHD plasma jets

    NASA Astrophysics Data System (ADS)

    Bellan, Paul

    2008-04-01

    Because space plasmas are neither confined by vacuum chamber walls nor have magnetic fields produced by physical coils, space plasmas have shapes that are much less determinate than lab plasmas. An experimental program underway at Caltech produces plasmas where the shape is neither fixed by a vacuum chamber wall nor imposed by an external coil set, but rather is allowed to be determined by self-organizing MHD processes subject to the constraint of imposed boundary conditions analogous to the boundary conditions of space plasmas. These self-organizing processes are believed to be fundamental to astrophysical jets, solar coronal loops, and MHD turbulence (e.g. Taylor relaxation). The experimental dynamics are sufficiently reproducible to allow detailed study despite the morphology being complex and dynamic. A surprising result has been the observation that instead of the plasma uniformly filling up the available volume, the plasma is spatially localized in a highly collimated, small diameter magnetic flux tube, the length and axis of which change in time in response to MHD forces. A model shows that the collimation results from stagnation of linked magnetic flux frozen into a MHD-driven jet that accelerates plasma from the wall into the flux tube, filling the flux tube with plasma. Jet flow has been imaged with a high-speed multi-frame camera, diagnosed via Doppler spectroscopy, and most recently (i) the collision between two opposing, color-coded jets flowing from opposite ends of a flux tube has been observed, and (ii) the collision of a jet with a target cloud has been observed.

  5. ?Linear Gas Jet with Tailored Density Profile"

    SciTech Connect

    KRISHNAN, Mahadevan

    2012-12-10

    Supersonic, highly collimated gas jets and gas-filled capillary discharge waveguides are two primary targets of choice for Laser Plasma Accelerators (LPA) . Present gas jets have lengths of only 2-4 mm at densities of 1-4E19 cm-3, sufficient for self trapping and electron acceleration to energies up to ~150 MeV. Capillary structures 3 cm long have been used to accelerate beams up to 1 GeV. Capillary discharges used in LPAs serve to guide the pump laser and optimize the energy gain. A wall-stabilized capillary discharge provides a transverse profile across the channel that helps guide the laser and combat diffraction. Gas injection via a fast nozzle at one end provides some longitudinal density control, to improve the coupling. Gas jets with uniform or controlled density profiles may be used to control electron bunch injection and are being integrated into capillary experiments to add tuning of density. The gas jet for electron injection has not yet been optimized. Our Ph-I results have provided the LPA community with an alternative path to realizing a 2-3GeV electron bunch using just a gas jet. For example, our slit/blade combination gives a 15-20mm long acceleration path with tunable density profile, serving as an alternative to a 20-mm long capillary discharge with gas injection at one end. In Ph-II, we will extend these results to longer nozzles, to see whether we can synthesize 30 or 40-mm long plasma channels for LPAs.

  6. Measurement of the Single Top Quark Cross Section in the Lepton Plus Jets Final State in Proton-Antiproton Collisions at a Center of Mass Energy of 1.96 TeV Using the CDF II Detector

    SciTech Connect

    Wu, Zhenbin

    2012-01-01

    We present a measurement of the single top quark cross section in the lepton plus jets final state using an integrated luminosity corresponding to 7.5 fb-1 of p\\bar p collision data collected by the Collider Detector at Fermilab. The single top candidate events are identified by the signature of a charged lepton, large missing transverse energy, and two or three jets with at least one of them identified as originating from a bottom quark. A new Monte Carlo generator POWHEG is used to model the single top quark production processes, which include s-channel, t-channel, and Wt-channel. A neural network multivariate method is exploited to discriminate the single top quark signal from the comparatively large backgrounds. We measure a single top production cross section of $3.04^{+0.57}_{-0.53} (\\mathrm{stat.~+~syst.})$ pb assuming $m_{\\rm top}=172.5$~GeV/$c^2$. In addition, we extract the CKM matrix element value $|V_{tb}|=0.96\\pm 0.09~(\\mathrm{stat.~+~syst.})\\ ± 0.05~(\\mathrm{theory})$ and set a lower limit of $|V_{tb}|>0.78$ at the 95% credibility level.

  7. Jet Noise Research at NASA

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda S.; Huff,Dennis

    2009-01-01

    A presentation outlining current jet noise work at NASA was given to the Naval Research Advisory Committee. Jet noise tasks in the Supersonics project of the Fundamental Aeronautics program were highlighted. The presentation gave an overview of developing jet noise reduction technologies and noise prediction capabilities. Advanced flow and noise diagnostic tools were also presented.

  8. Jet Noise Research at NASA

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda

    2008-01-01

    A presentation outlining current jet noise work at NASA was given at the NAVAIR Noise Workshop. Jet noise tasks in the Supersonics project of the Fundamental Aeronautics program were highlighted. The presentation gave an overview of developing jet noise reduction technologies and noise prediction capabilities. Advanced flow and noise diagnostic tools were also presented.

  9. TREAT MK III Loop Thermoelastoplastic Stress Analysis for the L03 Experiment

    SciTech Connect

    Kennedy, James M.

    1981-03-01

    The STRAW code was used to analyze the static response of a TREAT MK III loop subjected to thermal and mechanical loadings arising from an accident situation for the purpose of determining the defiections and stresses. This analysis provides safety support for the L03 reactivity accident study. The analysis was subdivided into two tasks: (1) an analysis of a flow blockage accident (Cases A and B), where all the energy is assumed deposited in the test leg, resulting in a temperature increase from 530°F to 1720°F, with a small internal pressure throughout the loop and (2) an analysis of a second flow blockage accident (Cases C and D), where again, all the energy is assumed to he deposited in the test leg, resulting in a temperature rise from 530°F to 1845°F, with a small internal pressure throughout the loop. The purpose of these two tasks was to determine if loop failure can occur with the thermal differential across the pump and test legs. Also of interest is whether an undesirable amount of loop lateral deflection will be caused by the thermal differential. A two dimensional analysis of the TREAT MK III loop was performed. The analysis accounted for material nonlinearities, both as a function of temperature and stress, and geometric nonlinearities arising from large deflections. Straight beam elements with annular cross sections were used to model the loop. The analyses show that the maximum strains are less than 21% of their failure strains for all subcases of Cases A and B. For all subcases of cases C and D, the maximum strains are less than 53% of their failure strains. The failure strain is 27.9% for the material at 530°F, 38.1% at 1720°F and 17.8% at 1845°F. Large lateral deflections are observed when the loop is not constrained except at its clamped support--as much as 8.6 inches. However, by accounting for the constraint of the concrete biological shield, the maximum lateral deflection was reduced to less than 0.05 inches at the points of concern.

  10. The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells

    SciTech Connect

    Ribeiro, Mariana P.C.; Nunes-Correia, Isabel; Santos, Armanda E.; Custódio, José B.A.

    2014-02-15

    Recent reports suggest that N-methyl-D-aspartate receptor (NMDAR) blockade by MK-801 decreases tumor growth. Thus, we investigated whether other ionotropic glutamate receptor (iGluR) antagonists were also able to modulate the proliferation of melanoma cells. On the other hand, the antiestrogen tamoxifen (TAM) decreases the proliferation of melanoma cells, and is included in combined therapies for melanoma. As the efficacy of TAM is limited by its metabolism, we investigated the effects of the NMDAR antagonist MK-801 in combination with TAM and its active metabolites, 4-hydroxytamoxifen (OHTAM) and endoxifen (EDX). The NMDAR blockers MK-801 and memantine decreased mouse melanoma K1735-M2 cell proliferation. In contrast, the NMDAR competitive antagonist APV and the AMPA and kainate receptor antagonist NBQX did not affect cell proliferation, suggesting that among the iGluR antagonists only the NMDAR channel blockers inhibit melanoma cell proliferation. The combination of antiestrogens with MK-801 potentiated their individual effects on cell biomass due to diminished cell proliferation, since it decreased the cell number and DNA synthesis without increasing cell death. Importantly, TAM metabolites combined with MK-801 promoted cell cycle arrest in G1. Therefore, the data obtained suggest that the activity of MK-801 and antiestrogens in K1735-M2 cells is greatly enhanced when used in combination. - Highlights: • MK-801 and memantine decrease melanoma cell proliferation. • The combination of MK-801 with antiestrogens inhibits melanoma cell proliferation. • These combinations greatly enhance the effects of the compounds individually. • MK-801 combined with tamoxifen active metabolites induces cell cycle arrest in G1. • The combination of MK-801 and antiestrogens is an innovative strategy for melanoma.

  11. Comparison of gaseous exhaust indices of the F109 turbofan using three different blends of petroleum-based Jet-A and camelina-based Jet-A

    NASA Astrophysics Data System (ADS)

    Kozak, Brian John

    This research project focused on the collection and comparison of gaseous exhaust emissions of the F109 turbofan engine using petroleum-based Jet-A and two different blends of camelina-based Jet-A. Simulated landing and takeoff cycles were used to collect gaseous exhaust emissions. Unburned hydrocarbon (HC), nitrogen oxide (NOx), and carbon moNOxide (CO) exhaust indices (EIm) were calculated using ICAO Annex 16 Volume II formulae. Statistical analyses were performed on the Elm data. There was no significant difference in HC EIm and CO EI m among the three fuels at takeoff thrust. There were significant differences among the fuels for NOx EIm. 50% Jet-A 50% camelina produced the highest NOx EIm, then 75% Jet-A 25% camelina and finally Jet-A. At climb thrust, both blends of camelina fuel produced higher NOx EIm but no difference in CO EIm and HC EIm as Jet-A. At approach thrust, both blends of camelina fuel produced higher NOx EIm, lower CO EIm, and no difference in HC EIm as Jet-A. At idle thrust, there was no significant difference among the fuels for NOx EIm. There were significant differences among the fuels for HC EIm. Jet-A and 50% Jet-A 50% both produced higher HC EIm as 75% Jet-A 25% camelina. There were significant differences among the fuels for CO EI m. Jet-A produced the highest CO EIm, then 75% Jet-A 25% camelina and finally 50% Jet-A 50% camelina.

  12. Relativistic HD and MHD modelling for AGN jets

    NASA Astrophysics Data System (ADS)

    Keppens, R.; Porth, O.; Monceau-Baroux, R.; Walg, S.

    2013-12-01

    Relativistic hydro and magnetohydrodynamics (MHD) provide a continuum fluid description for plasma dynamics characterized by shock-dominated flows approaching the speed of light. Significant progress in its numerical modelling emerged in the last two decades; we highlight selected examples of modern grid-adaptive, massively parallel simulations realized by our open-source software MPI-AMRVAC (Keppens et al 2012 J. Comput. Phys. 231 718). Hydrodynamical models quantify how energy transfer from active galactic nuclei (AGN) jets to their surrounding interstellar/intergalactic medium (ISM/IGM) gets mediated through shocks and various fluid instability mechanisms (Monceau-Baroux et al 2012 Astron. Astrophys. 545 A62). With jet parameters representative for Fanaroff-Riley type-II jets with finite opening angles, we can quantify the ISM volumes affected by jet injection and distinguish the roles of mixing versus shock-heating in cocoon regions. This provides insight in energy feedback by AGN jets, usually incorporated parametrically in cosmological evolution scenarios. We discuss recent axisymmetric studies up to full 3D simulations for precessing relativistic jets, where synthetic radio maps can confront observations. While relativistic hydrodynamic models allow one to better constrain dynamical parameters like the Lorentz factor and density contrast between jets and their surroundings, the role of magnetic fields in AGN jet dynamics and propagation characteristics needs full relativistic MHD treatments. Then, we can demonstrate the collimating properties of an overal helical magnetic field backbone and study differences between poloidal versus toroidal field dominated scenarios (Keppens et al 2008 Astron. Astrophys. 486 663). Full 3D simulations allow one to consider the fate of non-axisymmetric perturbations on relativistic jet propagation from rotating magnetospheres (Porth 2013 Mon. Not. R. Astron. Soc. 429 2482). Self-stabilization mechanisms related to the detailed

  13. Particle Acceleration in Jets

    NASA Technical Reports Server (NTRS)

    Nishikawa, Ken-Ichi

    2005-01-01

    Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks, e.g., active galactic nuclei (AGNs), gamma ray burst (GRBs), and Galactic microquasar systems usually have power-law emission spectra. Fermi acceleration is the mechanism usually assumed for the acceleration of particles in astrophysical environments.

  14. Jet Inlet Efficiency

    DTIC Science & Technology

    2013-08-08

    AFRL-RW-EG-TR-2014-044 Jet Inlet Efficiency Nigel Plumb Taylor Sykes -Green Keith Williams John Wohleber Munitions Aerodynamics Sciences...CONTRACT NUMBER N/A 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER N/A 6. AUTHOR(S) Nigel Plumb Taylor Sykes -Green Keith Williams John

  15. Vortex diode jet

    DOEpatents

    Houck, Edward D.

    1994-01-01

    A fluid transfer system that combines a vortex diode with a jet ejector to transfer liquid from one tank to a second tank by a gas pressurization method having no moving mechanical parts in the fluid system. The vortex diode is a device that has a high resistance to flow in one direction and a low resistance to flow in the other.

  16. Spectroscopy with Supersonic Jets.

    ERIC Educational Resources Information Center

    Skinner, Anne R.; Chandler, Dean W.

    1980-01-01

    Discusses a new technique that enables spectroscopists to study gas phase molecules at temperatures below 1 K, without traditional cryogenic apparatus. This technique uses supersonic jets as samples for gas molecular spectroscopy. Highlighted are points in the theory of supersonic flow which are important for applications in molecular…

  17. The physics of jets

    SciTech Connect

    Hofmann, W.

    1987-09-01

    Recent data on the fragmentation of quarks and gluons is discussed in the context of phenomenological models of parton fragmentation. Emphasis is placed on the experimental evidence for parton showers as compared to a fixed order QCD treatment, on new data on inclusive hadron production and on detailed studies of baryon production in jets.

  18. Jet lag prevention

    MedlinePlus

    ... zones. Jet lag occurs when your body's biological clock is not set with the time zone you ... Your body follows a 24-hour internal clock called a circadian rhythm. It tells your body when to go to sleep and when to wake up. Cues from your environment, such ...

  19. Jet Screech Noise Computation

    NASA Technical Reports Server (NTRS)

    Loh, Ching Y.; Hultgren, Lennart S.

    2003-01-01

    The near-field screech-tone noise of a typical underexpanded circular jet issuing from a sonic nozzle is simulated numerically. The self-sustained feedback loop is automatically established in the simulation. The computed shock-cell structure, acoustic wave length, screech tone frequencies, and sound pressure levels in the near field are in good agreement with existing experimental results.

  20. The Jet Travel Challenge

    ERIC Educational Resources Information Center

    Roman, Harry T.

    2007-01-01

    Airplane travelers are dismayed by the long lines and seemingly chaotic activities that precede boarding a full airplane. Surely, the one who can solve this problem is going to make many travelers happy. This article describes the Jet Travel Challenge, an activity that challenges students to create some alternatives to this now frustrating…

  1. Tracing Massive Protostellar Jets from Intermediate-Mass Protostars in the Carina Nebula

    NASA Astrophysics Data System (ADS)

    Reiter, A.

    2014-09-01

    We present new spectroscopy and imaging of four protostellar jets in the Carina nebula. Near-IR [Fe II] emission traces dense gas in the jet that is self-shielded from Lyman continuum photons from nearby O-type stars. New near-IR [Fe II] images reveal a substantial mass of dense, neutral gas that is not seen in the Halpha emission from these jets, leading to densities and mass-loss rate estimates an order of magnitude larger than those derived from the Halpha emission measure. Higher jet mass-loss rates require higher accretion rates, implying that these jets are driven by intermediate-mass (around 2 - 8 solar masses) protostars. Velocities from new proper motion and spectroscopic measurements fall among the velocities typically measured in lower-luminosity sources (100 - 200 km/s). We propose that these jets reflect essentially the same outflow phenomenon seen in low-mass protostars, but that the collimated atomic jet core is irradiated and rendered observable. Thus, the jets in Carina constitute a new view of collimated jets from intermediate-mass protostars that exist in a feedback-dominated environment, and offer strong additional evidence that stars up to 8 solar masses form by the same accretion mechanisms as low-mass stars.

  2. Jet injection into polyacrylamide gels: investigation of jet injection mechanics.

    PubMed

    Schramm-Baxter, Joy; Katrencik, Jeffrey; Mitragotri, Samir

    2004-08-01

    Jet injectors employ high-velocity liquid jets that penetrate into human skin and deposit drugs in the dermal or subdermal region. Although jet injectors have been marketed for a number of years, relatively little is known about the interactions of high-speed jets with soft materials such as skin. Using polyacrylamide gels as a model system, the mechanics of jet penetration, including the dependence of jet penetration on mechanical properties, was studied. Jets employed in a typical commercial injector, (orifice diameter: 152 microm, velocity: 170-180 m/s) were used to inject fluid into polyacrylamide gels possessing Young's moduli in the range of 0.06-0.77 MPa and hardness values in the range of 4-70 H(OO). Motion analysis of jet entry into polyacrylamide gels revealed that jet penetration can be divided into three distinct events: erosion, stagnation, and dispersion. During the erosion phase, the jet removed the gel at the impact site and led to the formation of a distinct cylindrical hole. Cessation of erosion induced a period of jet stagnation ( approximately 600 micros) characterized by constant penetration depth. This stage was followed by dispersion of the liquid into the gel. The dispersion took place by crack propagation and was nearly symmetrical with the exception of injections into 10% acrylamide (Young's modulus of 0.06 MPa). The penetration depth of the jets as well as the rate of erosion decreased with increasing Young's modulus. The mechanics of jet penetration into polyacrylamide gels provides an important tool for understanding jet injection into skin.

  3. Jet substructure using semi-inclusive jet functions in SCET

    NASA Astrophysics Data System (ADS)

    Kang, Zhong-Bo; Ringer, Felix; Vitev, Ivan

    2016-11-01

    We propose a new method to evaluate jet substructure observables in inclusive jet measurements, based upon semi-inclusive jet functions in the framework of Soft Collinear Effective Theory (SCET). As a first example, we consider the jet fragmentation function, where a hadron h is identified inside a fully reconstructed jet. We introduce a new semi-inclusive fragmenting jet function {{G}}_i^h(z={ω}_J/ω, {z}_h={ω}_h/{ω}_J,{ω}_J,R,μ ) , which depends on the jet radius R and the large light-cone momenta of the parton ` i' initiating the jet ( ω), the jet ( ω J ), and the hadron h ( ω h ). The jet fragmentation function can then be expressed as a semi-inclusive observable, in the spirit of actual experimental measurements, rather than as an exclusive one. We demonstrate the consistency of the effective field theory treatment and standard perturbative QCD calculations of this observable at next-to-leading order (NLO). The renormalization group (RG) equation for the semi-inclusive fragmenting jet function {{G}}_i^h(z,{z}_h,{ω}_J,R,μ ) are also derived and shown to follow exactly the usual timelike DGLAP evolution equations for fragmentation functions. The newly obtained RG equations can be used to perform the resummation of single logarithms of the jet radius parameter R up to next-to-leading logarithmic (NLL R ) accuracy. In combination with the fixed NLO calculation, we obtain NLO+NLL R results for the hadron distribution inside the jet. We present numerical results for pp → (jet h) X in the new framework, and find excellent agreement with existing LHC experimental data.

  4. Review of jet reconstruction algorithms

    NASA Astrophysics Data System (ADS)

    Atkin, Ryan

    2015-10-01

    Accurate jet reconstruction is necessary for understanding the link between the unobserved partons and the jets of observed collimated colourless particles the partons hadronise into. Understanding this link sheds light on the properties of these partons. A review of various common jet algorithms is presented, namely the Kt, Anti-Kt, Cambridge/Aachen, Iterative cones and the SIScone, highlighting their strengths and weaknesses. If one is interested in studying jets, the Anti-Kt algorithm is the best choice, however if ones interest is in the jet substructures then the Cambridge/Aachen algorithm would be the best option.

  5. The thermal conductivity of high modulus Zylon fibers between 400 mK and 4 K

    NASA Astrophysics Data System (ADS)

    Wikus, Patrick; Figueroa-Feliciano, Enectalí; Hertel, Scott A.; Leman, Steven W.; McCarthy, Kevin A.; Rutherford, John M.

    2008-11-01

    Zylon is a synthetic polyurethane polymer fiber featuring very high mechanical strength. Measurements of the thermal conductivity λZ(T) of high modulus Zylon fibers at temperatures between 400 mK and 4 K were performed to assess if they can be successfully employed in the design of high performance suspension systems for cold stages of adiabatic demagnetization refrigerators. The linear mass density of the yarn used in these measurements amounts to 3270 dtex, which is also a measure for the yarn's cross section. The experimental data for the thermal conductivity was fitted to a function of the form λZ=(1010±30)·TpWmmdtexK. This result was normalized to the breaking strength of the fibers and compared with Kevlar. It shows that Kevlar outperforms Zylon in the investigated temperature range. At 1.5 K, the thermal conductivity integral of Zylon yarn is twice as high as the thermal conductivity integral of Kevlar yarn with the same breaking strength. A linear mass density of 1 tex is equivalent to a yarn mass of 1 g/km. High modulus Zylon has a density of 1.56 g/cm 3.

  6. Verification of JUPITER Standard Analysis Method for Upgrading Joyo MK-III Core Design and Management

    NASA Astrophysics Data System (ADS)

    Maeda, Shigetaka; Ito, Chikara; Sekine, Takashi; Aoyama, Takafumi

    In the experimental fast reactor Joyo, loading of irradiation test rigs causes a decrease in excess reactivity because the rigs contain less fissile materials than the driver fuel. In order to carry out duty operation cycles using as many irradiation rigs as possible, it is necessary to upgrade the core performance to increase its excess reactivity and irradiation capacity. Core modification plans have been considered, such as the installation of advanced radial reflectors and reduction of the number of control rods. To implement such core modifications, it is first necessary to improve the prediction accuracy in core design and to optimize safety margins. In the present study, verification of the JUPITER fast reactor standard analysis method was conducted through a comparison between the calculated and the measured Joyo MK-III core characteristics, and it was concluded that the accuracy for a small sodium-cooled fast reactor with a hard neutron spectrum was within 5 % of unity. It was shown that, the performance of the irradiation bed core could be upgraded by the improvement of the prediction accuracy of the core characteristics and optimization of safety margins.

  7. Invited review article: A 10 mK scanning probe microscopy facility.

    PubMed

    Song, Young Jae; Otte, Alexander F; Shvarts, Vladimir; Zhao, Zuyu; Kuk, Young; Blankenship, Steven R; Band, Alan; Hess, Frank M; Stroscio, Joseph A

    2010-12-01

    We describe the design, development and performance of a scanning probe microscopy (SPM) facility operating at a base temperature of 10 mK in magnetic fields up to 15 T. The microscope is cooled by a custom designed, fully ultra-high vacuum (UHV) compatible dilution refrigerator (DR) and is capable of in situ tip and sample exchange. Subpicometer stability at the tip-sample junction is achieved through three independent vibration isolation stages and careful design of the dilution refrigerator. The system can be connected to, or disconnected from, a network of interconnected auxiliary UHV chambers, which include growth chambers for metal and semiconductor samples, a field-ion microscope for tip characterization, and a fully independent additional quick access low temperature scanning tunneling microscope (STM) and atomic force microscope (AFM) system. To characterize the system, we present the cooling performance of the DR, vibrational, tunneling current, and tip-sample displacement noise measurements. In addition, we show the spectral resolution capabilities with tunneling spectroscopy results obtained on an epitaxial graphene sample resolving the quantum Landau levels in a magnetic field, including the sublevels corresponding to the lifting of the electron spin and valley degeneracies.

  8. Development of Cryogenic Engine for GSLV MkIII: Technological Challenges

    NASA Astrophysics Data System (ADS)

    Praveen, RS; Jayan, N.; Bijukumar, KS; Jayaprakash, J.; Narayanan, V.; Ayyappan, G.

    2017-02-01

    Cryogenic engine capable of delivering 200 kN thrust is being developed for the first time in the country by ISRO for powering the upper stage of GSLV Mk-III, the next generation launch vehicle of ISRO capable of launching four tonne class satellites to Geo-synchronous Transfer Orbit(GTO). Development of this engine started a decade ago when various sub-systems development and testing were taken up. Starting with injector element development, the design, realization and testing of the major sub-systems viz the gas generator, turbopumps, start-up system and thrust chamber have been successfully done in a phased manner before conducting a series of developmental tests in the integrated engine mode. Apart from the major sub-systems, many critical components like the igniter, control components etc were independently developed and qualified. During the development program many challenges were faced in almost all areas of propulsion engineering. Systems engineering of the engine was another key challenge in the realization. This paper gives an outlook on various technological challenges faced in the key areas related to the engine development, insight to the solutions and measures taken to overcome the challenges.

  9. Numerical Simulations of Solar Spicule Jets at a Magnetic Null-Point

    NASA Astrophysics Data System (ADS)

    Smirnova, V.; Konkol, P. M.; Solov'ev, A. A.; Murawski, K.

    2016-11-01

    Two-dimensional numerical simulations of jet-like structures in the solar atmosphere are performed. These structures result from a pressure pulse that is launched at the null point of a potential magnetic arcade. The plasma jet exhibits a double structure with two components: (a) dense, cool, and short vertical stream and (b) a less dense, hot and tall part of the jet. The upper part of the hot and tall jet may represent a direct response of the system to the pressure pulse launched at the null point, and the second, slower cool and dense part of the jet is formed later through the stretching up of the stream as a result of plasma evacuation from the top of the magnetic arcade. Numerical results show that jet-like structures mimic some properties of both type I and type II spicules, according to the classification provided by De Pontieu et al. ( Publ. Astron. Soc. Japan 59, S655, 2007).

  10. Jet propagation through energetic materials

    SciTech Connect

    Pincosy, P; Poulsen, P

    2004-01-08

    In applications where jets propagate through energetic materials, they have been observed to become sufficiently perturbed to reduce their ability to effectively penetrate subsequent material. Analytical calculations of the jet Bernoulli flow provides an estimate of the onset and extent of such perturbations. Although two-dimensional calculations show the back-flow interaction pressure pulses, the symmetry dictates that the flow remains axial. In three dimensions the same pressure impulses can be asymmetrical if the jet is asymmetrical. The 3D calculations thus show parts of the jet having a significant component of radial velocity. On the average the downstream effects of this radial flow can be estimated and calculated by a 2D code by applying a symmetrical radial component to the jet at the appropriate position as the jet propagates through the energetic material. We have calculated the 3D propagation of a radio graphed TOW2 jet with measured variations in straightness and diameter. The resultant three-dimensional perturbations on the jet result in radial flow, which eventually tears apart the coherent jet flow. This calculated jet is compared with jet radiographs after passage through the energetic material for various material thickness and plate thicknesses. We noted that confinement due to a bounding metal plate on the energetic material extends the pressure duration and extent of the perturbation.

  11. Interacting jets from binary protostars

    NASA Astrophysics Data System (ADS)

    Murphy, G. C.; Lery, T.; O'Sullivan, S.; Spicer, D.; Bacciotti, F.; Rosen, A.

    2008-02-01

    Aims: We investigate potential models that could explain why multiple proto-stellar systems predominantly show single jets. During their formation, stars most frequently produce energetic outflows and jets. However, binary jets have only been observed in a very small number of systems. Methods: We model numerically 3D binary jets for various outflow parameters. We also model the propagation of jets from a specific source, namely L1551 IRS 5, known to have two jets, using recent observations as constraints for simulations with a new MHD code. We examine their morphology and dynamics, and produce synthetic emission maps. Results: We find that the two jets interfere up to the stage where one of them is almost destroyed or engulfed into the second one. We are able to reproduce some of the observational features of L1551 such as the bending of the secondary jet. Conclusions: While the effects of orbital motion are negligible over the jets dynamical timeline, their interaction has significant impact on their morphology. If the jets are not strictly parallel, as in most observed cases, we show that the magnetic field can help the collimation and refocusing of both of the two jets.

  12. Flow cytometer jet monitor system

    DOEpatents

    Van den Engh, Ger

    1997-01-01

    A direct jet monitor illuminates the jet of a flow cytometer in a monitor wavelength band which is substantially separate from the substance wavelength band. When a laser is used to cause fluorescence of the substance, it may be appropriate to use an infrared source to illuminate the jet and thus optically monitor the conditions within the jet through a CCD camera or the like. This optical monitoring may be provided to some type of controller or feedback system which automatically changes either the horizontal location of the jet, the point at which droplet separation occurs, or some other condition within the jet in order to maintain optimum conditions. The direct jet monitor may be operated simultaneously with the substance property sensing and analysis system so that continuous monitoring may be achieved without interfering with the substance data gathering and may be configured so as to allow the front of the analysis or free fall area to be unobstructed during processing.

  13. Measurement of b-jet Shapes in Inclusive Jet Production in p anti-p Collisions at s**(1/2) = 1.96-TeV

    SciTech Connect

    Aaltonen, T.

    2008-06-01

    We present a measurement of the shapes of b-jets using 300 pb{sup -1} of data obtained with the upgraded Collider Detector at Fermilab (CDF II) in p{bar p} collisions at center of mass energy {radical}s = 1.96 TeV. This measurement covers a wide transverse momentum range, from 52 to 300 GeV/c. Samples of heavy-flavor enhanced jets together with inclusive jets are used to extract the average shapes of b-jets. The b-jets are expected to be broader than inclusive jets. Moreover, b-jets containing a single b-quark are expected to be narrower than those containing a b{bar b} pair from gluon splitting. The measured b-jet shapes are found to be significantly broader than expected from the pythia and HERWIG Monte Carlo simulations. This effect may arise from an underestimation of the fraction of b-jets originating from gluon splitting in these simulations.

  14. Radiant Energy Power Source for Jet Aircraft

    SciTech Connect

    Doellner, O.L.

    1992-02-01

    This report beings with a historical overview on the origin and early beginnings of Radiant Energy Power Source for Jet Aircraft. The report reviews the work done in Phase I (Grant DE-FG01-82CE-15144) and then gives a discussion of Phase II (Grant DE-FG01-86CE-15301). Included is a reasonably detailed discussion of photovoltaic cells and the research and development needed in this area. The report closes with a historical perspective and summary related to situations historically encountered on projects of this nature. 15 refs.

  15. Searches in photon and jet states

    SciTech Connect

    Soha, A.; /UC, Davis

    2007-06-01

    The authors present recent results from the Collider Detector at Fermilab (CDF) and D0 experiments using data from proton-antiproton collisions with {radical}s = 1.96 TeV at Run II of the Fermilab Tevatron. New physics may appear in events with high transverse momentum objects, including photons and quark or gluon jets. The results described here are of signature-based searches and model-based searches probing supersymmetry, leptoquarks, 4th generation quarks, and large extra dimensions.

  16. Effect of NMDA receptor antagonist MK-801 on light-induced Fos expression in the suprachiasmatic nuclei and on melatonin production in the Syrian hamster.

    PubMed

    Vuillez, P; Jacob, N; Teclemariam-Mesbah, R; Van Rossum, A; Vivien-Roels, B; Pévet, P

    1998-09-01

    In mammals, circadian rhythms generated by the suprachiasmatic nuclei (SCN) are daily synchronized by a light-dark cycle. Photic information is transmitted to the SCN mainly through the direct retinohypothalamic tract, the neurotransmitters involved being excitatory amino acids. It is also commonly accepted that photoperiodic information coming from the retina via the SCN is transduced by the pineal into a nocturnal signal, i.e. melatonin production. Light exposure at night induces (1) an inhibition of melatonin synthesis and (2) an expression of c-fos in numerous cells of SCN. To determine the role of the NMDA receptor in these effects, we treated Syrian hamsters with ip injections of MK-801, a noncompetitive NMDA receptor antagonist. Several subpopulations of light-sensitive cells in the SCN are affected by MK-801. According to previous studies, MK-801 inhibits light-induced Fos immunoreactivity mainly in the most ventral part of the SCN. However, we observed that numerous other cells are still activated by light. When light is applied in the middle of the night, MK-801 pretreatment does not reduce Fos-ir in the dorsal SCN. At the beginning of the night, labeled cells in this part of the nucleus appear even more numerous after MK-801. We also found that MK-801 fails to reduce the light-induced inhibition of melatonin synthesis. Moreover, in control animals, which received no light stimulation, ip injection of MK-801 induces by itself a dose-dependent inhibition of melatonin production.

  17. Coronal Jets in Closed Magnetic Regions on the Sun

    NASA Astrophysics Data System (ADS)

    Wyper, Peter Fraser; DeVore, C. R.

    2015-04-01

    Coronal jets are dynamic, collimated structures observed in solar EUV and X-ray emission. They appear predominantly in the open field of coronal holes, but are also observed in areas of closed field, especially active regions. A common feature of coronal jets is that they originate from the field above a parasitic polarity of opposite sign to the surrounding field. Some process - such as instability onset or flux emergence - induces explosive reconnection between the closed “anemone” field and the surrounding open field that generates the jet. The lesser number of coronal jets in closed-field regions suggests a possible stabilizing effect of the closed configuration with respect to coronal jet formation. If the scale of the jet region is small compared with the background loop length, as in for example type II spicules, the nearby magnetic field may be treated as locally open. As such, one would expect that if a stabilizing effect exists it becomes most apparent as the scale of the anemone region approaches that of the background coronal loops.To investigate if coronal jets are indeed suppressed along shorter coronal loops, we performed a number of simulations of jets driven by a rotation of the parasitic polarity (as in the previous open-jet calculations by Pariat et. al 2009, 2010, 2015) embedded in a large-scale closed bipolar field. The simulations were performed with the state of the art Adaptively Refined Magnetohydrodynamics Solver. We will report here how the magnetic configuration above the anemone region determines the nature of the jet, when it is triggered, and how much of the stored magnetic energy is released. We show that regions in which the background field and the parasitic polarity region are of comparable scale naturally suppress explosive energy release. We will also show how in the post-jet relaxation phase a combination of confined MHD waves and weak current layers are generated by the jet along the background coronal loops, both of which

  18. Nature or Nurture: the peculiar HH 900 jet and outflow system in the Carina nebula

    NASA Astrophysics Data System (ADS)

    Reiter, Megan; Smith, Nathan; Kiminki, Megan M.; Bally, John

    2015-01-01

    We present new optical and IR spectroscopy and Hubble Space Telescope imaging of HH 900, a peculiar protostellar outflow in the Carina nebula. Previous Hα imaging from HST revealed an unusually broad, bipolar outflow emerging from a small, tadpole-shaped globule that is illuminated by the many O-type stars in nearby Trumpler 16. Near-IR narrowband [Fe II] images reveal a symmetric, collimated jet that bisects the broad outflow traced by Hα. In a giant H II region like Carina, [Fe II] emission traces dense gas that is self-shielded from Lyman continuum photons from nearby O-type stars, but is excited by non-ionizing FUV photons that penetrate the ionization front within the jet. New Gemini AO images of near-IR H2 emission show that molecules survive in the outflow, and follow the Hα morphology. Position-velocity diagrams of the three lines also reveal very different kinematics. [Fe II] traces steady, jet-like velocities that are faster than those observed in H2 emission. Most strikingly, Hα velocities resemble the Hubble wedges seen in the position-velocity diagrams of some molecular outflows, but few other protostellar jets. We propose that [Fe II] emission traces the protostellar jet itself while H2 emission reveals the molecules that (briefly) survive in the outflow, and Hα traces the ionized skin of the outflow sheath entrained by the jet. The high estimated mass-loss rate of the jet requires a high accretion rate, implying that the unseen driving source is an intermediate-mass (~2-8 Msun) protostar. We propose that HH 900 provides a bridge between molecular outflows driven by deeply embedded sources, and jets from unobscured low-mass protostars because external irradiation from nearby O-type stars illuminates both the collimated atomic jet core and the material it sweeps up.

  19. Minkowski's Object: A Starburst Triggered by a Radio Jet, Revisited

    SciTech Connect

    Croft, S; van Breugel, W; de Vries, W; Dopita, M; Martin, C; Morganti, R; Neff, S; Oosterloo, T; Schiminovich, D; Stanford, S A; van Gorkom, J

    2006-02-07

    We present neutral hydrogen, ultraviolet, optical and near-infrared imaging, as well as optical spectroscopic observations of Minkowski's Object (MO), a star forming system at the end of a radio jet associated with NGC541 at the center of a cluster of galaxies, Abell 194. The observations strengthen the evidence, first presented in 1985, that MO is a small, peculiar galaxy in which the star formation has been triggered by the radio jet. Key new results are the discovery of a double H I cloud with a mass of 4.9 x 10{sup 8} M{sub {circle_dot}} straddling the radio jet downstream from MO at the location where the jet changes direction and decollimates; a strong detection of MO at near- and far-UV wavelengths and in H{alpha}, both of which also show a double structure; and what appear to be numerous H II regions and associated clusters in MO. The UV morphology of MO along the radio jet resembles the radio-aligned, rest-frame UV morphologies seen in many high redshift radio galaxies, which are also thought to be caused by jet-induced star formation. The UV, optical, and near-IR data show that the stellar population is dominated by a 7.5Myr-old instantaneous burst, with a total stellar mass of 1.9 x 10{sup 7} M{sub {circle_dot}}.

  20. Jet Signatures in the Spectra of Accreting Black Holes

    NASA Astrophysics Data System (ADS)

    O' Riordan, Michael; Pe'er, Asaf; McKinney, Jonathan C.

    2016-03-01

    Jets are observed as radio emission in active galactic nuclei and during the low/hard state in X-ray binaries (XRBs), but their contribution at higher frequencies has been uncertain. We study the dynamics of jets in XRBs using the general-relativistic magnetohydrodynamic code HARM. We calculate the high-energy spectra and variability properties using a general-relativistic radiative transport code based on grmonty. We find the following signatures of jet emission: (i) a significant γ-ray peak above ˜1022 Hz, (ii) a break in the optical/UV spectrum, with a change from ν {L}ν ˜ {ν }0 to ν {L}ν ˜ ν , followed by another break at higher frequencies where the spectrum roughly returns to ν {L}ν ˜ {ν }0, and (iii) a pronounced synchrotron peak near or below ˜1014 Hz indicates that a significant fraction of any observed X-ray emission originates in the jet. We investigate the variability during a large-scale magnetic field inversion in which the Blandford-Znajek (BZ) jet is quenched and a new transient hot reconnecting plasmoid is launched by the reconnecting field. The ratio of the γ-rays to X-rays changes from {L}γ /{L}{{X}}\\gt 1 in the BZ jet to {L}γ /{L}{{X}}\\lt 1 during the launching of the transient plasmoid.

  1. A Novel Interaction between CCaMK and a Protein Containing the Scythe_N Ubiquitin-Like Domain in Lotus japonicus1[C][W][OA

    PubMed Central

    Kang, Heng; Zhu, Hui; Chu, Xiaojie; Yang, Zhenzhen; Yuan, Songli; Yu, Dunqiang; Wang, Chao; Hong, Zonglie; Zhang, Zhongming

    2011-01-01

    In the Rhizobium-legume symbiosis, calcium/calmodulin-dependent protein kinase (CCaMK) is a key regulator for both rhizobial infection and nodule organogenesis. Deregulation of CCaMK by either a point mutation in the autophosphorylation site or the deletion of the carboxyl-terminal regulatory domain results in spontaneous nodule formation without rhizobia. However, the underlying biochemical mechanisms are poorly understood. Here, using the kinase domain of CCaMK as a bait in yeast two-hybrid screening, we identify a novel protein, CIP73 (for CCaMK-interacting protein of approximately 73 kD), that interacts with CCaMK. CIP73 contains a Scythe_N ubiquitin-like domain and belongs to the large ubiquitin superfamily. Deletion and mutagenesis analysis demonstrate that CIP73 could only interact with CCaMK when the calmodulin-binding domain and three EF-hand motifs are removed from the kinase domain. The amino-terminal 80 amino acid residues (80–160) of CCaMK are required for interacting with CIP73 in yeast cells. On the other hand, protein pull-down assay and bimolecular fluorescence complementation assay in Nicotiana benthamiana show that the full-length CCaMK could interact with CIP73 in vitro and in planta. Importantly, CCaMK phosphorylates the amino terminus of CIP73 in a Ca2+/calmodulin-dependent manner in vitro. CIP73 transcripts are preferentially expressed in roots, and very low expression is detected in leaves, stems, and nodules. The expression in roots is significantly decreased after inoculation of Mesorhizobium loti. RNA interference knockdown of CIP73 expression by hairy root transformation in Lotus japonicus led to decreased nodule formation, suggesting that CIP73 performed an essential role in nodulation. PMID:21209278

  2. Possible involvement of nitric oxide (NO) signaling pathway in the antidepressant-like effect of MK-801(dizocilpine), a NMDA receptor antagonist in mouse forced swim test.

    PubMed

    Dhir, Ashish; Kulkarni, S K

    2008-03-01

    L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) is an important signaling pathway involved in depression. With this information, the present study aimed to study the involvement of this signaling pathway in the antidepressant-like action of MK-801 (dizocilpine; N-methyl-d-aspartate receptor antagonist) in the mouse forced-swim test. Total immobility period was recorded in mouse forced swim test for 6 min. MK-801 (5-25 microg/kg., ip) produced a U-shaped curve in reducing the immobility period. The antidepressant-like effect of MK-801 (10 microg/kg, ip) was prevented by pretreatment with L-arginine (750 mg/kg, ip) [substrate for nitric oxide synthase (NOS)]. Pretreatment of mice with 7-nitroindazole (7-NI) (25 mg/kg, ip) [a specific neuronal nitric oxide synthase inhibitor] produced potentiation of the action of subeffective dose of MK-801 (5 microg/kg, ip). In addition, treatment of mice with methylene blue (10 mg/kg, ip) [direct inhibitor of both nitric oxide synthase and soluble guanylate cyclase] potentiated the effect of MK-801 (5 microg/kg, ip) in the forced-swim test. Further, the reduction in the immobility period elicited by MK-801 (10 microg/kg, ip) was also inhibited by pretreatment with sildenafil (5 mg/kg, ip) [phosphodiesterase 5 inhibitor]. The various modulators used in the study and their combination did not produce any changes in locomotor activity per se and in combination with MK-801. MK-801 however, at higher doses (25 microg/kg, ip) produced hyperlocomotion. The results demonstrated the involvement of nitric oxide signaling pathway in the antidepressant-like effect of MK-801 in mouse forced-swim test.

  3. Structural characterization of the ribonuclease H-like type ASKHA superfamily kinase MK0840 from Methanopyrus kandleri.

    PubMed

    Schacherl, Magdalena; Waltersperger, Sandro; Baumann, Ulrich

    2013-12-01

    Murein recycling is a process in which microorganisms recover peptidoglycan-degradation products in order to utilize them in cell wall biosynthesis or basic metabolic pathways. Methanogens such as Methanopyrus kandleri contain pseudomurein, which differs from bacterial murein in its composition and branching. Here, four crystal structures of the putative sugar kinase MK0840 from M. kandleri in apo and nucleotide-bound states are reported. MK0840 shows high similarity to bacterial anhydro-N-acetylmuramic acid kinase, which is involved in murein recycling. The structure shares a common fold with panthothenate kinase and the 2-hydroxyglutaryl-CoA dehydratase component A, both of which are members of the ASKHA (acetate and sugar kinases/Hsc70/actin) superfamily of phosphotransferases. Local conformational changes in the nucleotide-binding site between the apo and holo forms are observed upon nucleotide binding. Further insight is given into domain movements and putative active-site residues are identified.

  4. cGMP Production of the Radiopharmaceutical [(18) F]MK-6240 for PET imaging of Human Neurofibrillary Tangles.

    PubMed

    Collier, Thomas Lee; Yokell, Daniel L; Livni, Eli; Rice, Peter A; Celen, Sofie; Serdons, Kim; Neelamegam, Ramesh; Bormans, Guy; Harris, Dawn; Walji, Abbas; Hostetler, Eric D; Bennacef, Idriss; Vasdev, Neil

    2017-02-09

    Fluorine-18 labelled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18) F]MK-6240) is a novel potent and selective PET radiopharmaceutical for detecting human neurofibrillary tangles, which are made up of aggregated tau protein. Herein, we report the fully automated two-step radiosynthesis of [(18) F]MK-6240 using a commercially available radiosynthesis module, GE Healthcare Tracerlab(TM) FXFN . Nucleophilic fluorination of the 5-diBoc-6-nitro precursor with potassium cryptand [(18) F]fluoride (K[(18) F]/K222 ) was carried out by conventional heating, followed by acid deprotection and semi-preparative HPLC under isocratic conditions. The isolated product was diluted with formulation solution and sterile filtered under Current Good Manufacturing Practices (cGMPs), and quality control procedures were established to validate this radiopharmaceutical for human use. At the end of synthesis, 6.3 - 9.3 GBq (170 - 250 mCi) of [(18) F]MK-6240 was formulated and ready for injection, in an uncorrected radiochemical yield of 7.5 ± 1.9% (relative to starting [(18) F]fluoride) with a specific activity of 222 ± 67 GBq/µmol (6.0 ± 1.8 Ci/µmol) at the end of synthesis (90 min; n = 3). [(18) F]MK-6240 was successfully validated for human PET studies meeting all FDA and USP requirements for a PET radiopharmaceutical. The present method can be easily adopted for use with other radiofluorination modules for widespread clinical research use.

  5. Production of L-arabinose from corn hull arabinoxylan by Arthrobacter aurescens MK5 α-L-arabinofuranosidase.

    PubMed

    Kurakake, Masahiro; Takao, Jyunpei; Asano, Osamu; Tanimoto, Hiroko; Komaki, Toshiaki

    2011-03-01

    Arabinoxylans, which are comprised of a xylan backbone to which are attached glycosyl units that are primarily L-arabinofuranosyl units, are ubiquitous among plant species where it is a constituent of the cell wall. Arabinoxylan has attracted much attention as a potential biomass resource and L-arabinose has recently been reported to possess functional properties that are effective in the treatment of diabetes. Here, we report an α-L-arabinofuranohydrolase, isolated from the soil microbe Arthrobacter aurescens strain MK5, effective in releasing L-arabinose from corn hull arabinoxylan. When A. aurescens strain MK5 was grown in a liquid medium, corn hull arabinoxylan, which has a higher arabinose content (Ara/Xyl = 0.6) than oat spelts xylan (Ara/Xyl = 0.12), induced more efficient arabinoxylan hydrolase production. Analysis of enzyme activity in the culture broth revealed that arabinoxylan hydrolase activity was high, and α-L-arabinofuranosidase and β-xylosidase activities were low. The optimum pH of the MK5 arabinoxylan hydrolase at 40 °C was around 7 and enzyme activity was relatively stable at an alkaline pH up to 9.5. The optimum temperature at pH 7 was around 50 °C and enzyme activity was stable under 50 °C. During the hydrolysis of corn hull arabinoxylan, only L-arabinose was released and 45.1% maximum sugar recovery was achieved. The A. aurescens MK5 enzyme was a typical arabinoxylan α-L-arabinofuranohydrolase and was most effective at releasing L-arabinose from corn hull arabinoxylan, which has a high arabinose content. This enzyme may have important industrial applications.

  6. Modulation of cholestasis-induced antinociception in rats by two NMDA receptor antagonists: MK-801 and magnesium sulfate.

    PubMed

    Hasanein, Parisa; Parviz, Mohsen; Keshavarz, Mansoor; Javanmardi, Kazem; Allahtavakoli, Mohammad; Ghaseminejad, Majid

    2007-01-12

    Acute cholestasis is associated with increased activity of the endogenous opioid system that results to changes including analgesia. N-methyl-d-aspartate (NMDA) receptors are involved in the nociceptive pathway and play a major role in the development of morphine induced analgesia. The magnesium acts as a non-competitive NMDA receptor antagonist by blocking the NMDA receptor channel. Considering the reported antinociceptive effect of magnesium sulfate as a NMDA receptor antagonist and the existence of close functional links between NMDA receptor antagonists and magnesium with the opioid system, we studied the effect of acute and chronic administration of MK-801 as a NMDA antagonist and magnesium sulfate on modulation of nociception in an experimental model of elevated endogenous opioid tone, acute cholestasis, using the tail-flick paradigm. Cholestasis was induced by ligation of the main bile duct using two ligatures and then transsection of the duct at the midpoint between them. A significant increase (P<0.001) in nociception threshold was observed in bile duct ligated rats compared to unoperated and sham-operated animals. In acute treatment, MK-801 (0.1 mg/kg, b.i.d), but not magnesium (150 mg/kg magnesium sulfate, i.e. 30 mg/kg of Mg(+2), i.p., b.i.d.) increased antinociception in cholestatic rats compared to saline treated cholestatics (P<0.05). In chronic treatment, administration of MK-801 or magnesium sulfate for 7 consecutive days, increased tail-flick latency (P<0.05, P<0.01) in cholestatic animals compared to saline treated cholestatics. These data showed that NMDA receptor pathway is involved in modulation of cholestasis-induced antinociception in rats and that repeated dosages of magnesium sulfate similar to MK-801 is able to modulate nociception in cholestasis.

  7. Protection Against Sarin-Induced Seizures in Rats by Direct Brain Microinjection of Scopolamine, Midazolam or MK-801

    DTIC Science & Technology

    2010-01-01

    CONTRACT NUMBER scopolamine , midazolam or MK-801 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Skovira, JW, McDonough, JH, Shih...ORGANIZATION REPORT NUMBER US Army Medical Research Institute of Chemical Defense ATTN: MCMR-CDR-P 3100 Ricketts Point Road Aberdeen Proving... Medical Research Institute Aberdeen Proving Ground, MD of Chemical Defense 21010-5400 ATTN: MCMR-CDZ-I 11. SPONSOR/MONITOR’S REPORT 3100 Ricketts

  8. Identification of Electrode Respiring, Hydrocarbonoclastic Bacterial Strain Stenotrophomonas maltophilia MK2 Highlights the Untapped Potential for Environmental Bioremediation

    PubMed Central

    Venkidusamy, Krishnaveni; Megharaj, Mallavarapu

    2016-01-01

    Electrode respiring bacteria (ERB) possess a great potential for many biotechnological applications such as microbial electrochemical remediation systems (MERS) because of their exoelectrogenic capabilities to degrade xenobiotic pollutants. Very few ERB have been isolated from MERS, those exhibited a bioremediation potential toward organic contaminants. Here we report once such bacterial strain, Stenotrophomonas maltophilia MK2, a facultative anaerobic bacterium isolated from a hydrocarbon fed MERS, showed a potent hydrocarbonoclastic behavior under aerobic and anaerobic environments. Distinct properties of the strain MK2 were anaerobic fermentation of the amino acids, electrode respiration, anaerobic nitrate reduction and the ability to metabolize n-alkane components (C8–C36) of petroleum hydrocarbons (PH) including the biomarkers, pristine and phytane. The characteristic of diazoic dye decolorization was used as a criterion for pre-screening the possible electrochemically active microbial candidates. Bioelectricity generation with concomitant dye decolorization in MERS showed that the strain is electrochemically active. In acetate fed microbial fuel cells (MFCs), maximum current density of 273 ± 8 mA/m2 (1000 Ω) was produced (power density 113 ± 7 mW/m2) by strain MK2 with a coulombic efficiency of 34.8%. Further, the presence of possible alkane hydroxylase genes (alkB and rubA) in the strain MK2 indicated that the genes involved in hydrocarbon degradation are of diverse origin. Such observations demonstrated the potential of facultative hydrocarbon degradation in contaminated environments. Identification of such a novel petrochemical hydrocarbon degrading ERB is likely to offer a new route to the sustainable bioremedial process of source zone contamination with simultaneous energy generation through MERS. PMID:28018304

  9. MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol.

    PubMed

    Deiana, Serena; Watanabe, Akihito; Yamasaki, Yuki; Amada, Naoki; Kikuchi, Tetsuro; Stott, Colin; Riedel, Gernot

    2015-12-01

    Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801) for induction of social withdrawal in rats and assessed the efficacy of several atypical antipsychotics with different pharmacological profiles as putative treatment. In addition, we reasoned that the marijuana constituent cannabidiol (CBD) may provide benefit or could be proposed as an adjunct treatment in combination with antipsychotics. Hooded Lister rats were tested in the three-chamber version for social interaction, with an initial novelty phase, followed after 3 min by a short-term recognition memory phase. No drug treatment affected sociability. However, distinct effects on social recognition were revealed. MK-801 reduced social recognition memory at all doses (>0.03 mg/kg). Predosing with aripiprazole dose-dependently (2 or 10 mg/kg) prevented the memory decline, but doses of 0.1 mg/kg risperidone or 1 mg/kg olanzapine did not. Intriguingly, CBD impaired social recognition memory (12 and 30 mg/kg) but did not rescue the MK-801-induced deficits. When CBD was combined with protective doses of aripiprazole (CBD-aripiprazole at 12 :  or 5 : 2 mg/kg) the benefit of the antipsychotic was lost. At the same time, activity-related changes in behaviour were excluded as underlying reasons for these pharmacological effects. Collectively, the combined activity of aripiprazole on dopamine D2 and serotonin 5HT1A receptors appears to provide a significant advantage over risperidone and olanzapine with respect to the rescue of cognitive deficits reminiscent of schizophrenia. The differential pharmacological properties of CBD, which are seemingly beneficial in human patients, did not back-translate and rescue the MK-801-induced social memory deficit.

  10. Radiatively cooled supersonic plasma jets generated in wire array Z-pinches

    NASA Astrophysics Data System (ADS)

    Bland, Simon; Lebedev, Sergey; Chittenden, Jerry; Beg, F. N.; Ciardi, A.; Haines, M. G.

    2000-10-01

    We will present experiments on the generation of a highly supersonic plasma jet by a convergent plasma flow, produced by electrodynamic acceleration of plasma in a conical array of fine metallic wires (a modification of the wire array Z-pinch [1]). Stagnation of the plasma flow on the axis of symmetry forms a standing conical shock, which effectively collimates the flow in the axial direction. This scenario is essentially similar to that discussed by Cantó et al. [2] as a possible, purely hydrodynamic mechanism of jet formation in young stellar objects. Experiments using different materials (Al, Fe and W) show that a highly supersonic (M 20) and a well-collimated jet is generated when the radiative cooling rate of the plasma is significant. The interaction of this jet with a plasma target could be used for scaled [3] laboratory astrophysical experiments on hydrodynamic instabilities in decelerated plasma flow. [1] M.K. Matzen, Phys. Plasmas v.4, 1519 (1997) [2] J. Cantó, et. al. Astron. Astrophys. v.192, 287 (1994). [3] D. Ryutov et al., ApJ, v.518, 821 (1999)

  11. What can we learn about extragalactic jets from galactic jets?

    NASA Astrophysics Data System (ADS)

    Wiseman, Jennifer; Biretta, John

    2002-05-01

    Jets are powerful features of extragalactic radio sources; yet jets are also seen in young stellar objects and X-ray binaries within our own galaxy. These occupy a very different parameter space from the extragalactic jets, and yet many are similar in appearance and nature to their powerful extragalactic cousins. In many cases far more information is available for the galactic jets, due to, e.g., rapid evolution and knowledge of emission line ratios and Doppler velocities. We review properties of galactic jets and speculate at implications they have for extragalactic ones. Specifically we consider central engine mass, jet opening angle and Mach number, the nature of the emission knots, the symmetry of the ejection process, and the source history.

  12. Jet decorrelation and jet shapes at the Tevatron

    SciTech Connect

    Heuring, T.C.

    1996-07-01

    We present results on measurements of jet shapes and jet azimuthal decorrelation from {bar p}P collisions at {radical}s = 1.8 TeV using data collected during the 1992-1993 run of the Fermilab Tevatron. Jets are seen to narrow both with increasing Awe {sub TTY} and increasing rapidity. While HERWIG, a puritan shower Monte Carlo, predicts slightly narrower jets, it describes the trend of the data well; NO CD described qualitative features of the data but is sensitive to both renormalization scale and jet definitions. Jet azimuthal decorrelation has been measured out to five units of pseudorapidity. While next-to-leading order CD and a leading-log approximation based on BFKL resummation fail to reproduce the effect, HERWIG describes the data well.

  13. Jet hadrochemistry as a characteristic of jet quenching

    NASA Astrophysics Data System (ADS)

    Sapeta, S.; Wiedemann, U. A.

    2008-05-01

    Jets produced in nucleus nucleus collisions at the LHC are expected to be strongly modified due to the interaction of the parton shower with the dense QCD matter. Here, we point out that jet quenching can leave signatures not only in the longitudinal and transverse jet energy and multiplicity distributions, but also in the hadrochemical composition of the jet fragments. In particular, we show that even in the absence of medium-effects at or after hadronization, the medium-modification of the parton shower may result in significant changes in jet hadrochemistry. We discuss how jet hadrochemistry can be studied within the high-multiplicity environment of nucleus nucleus collisions at the LHC.

  14. Far Noise Field of Air Jets and Jet Engines

    NASA Technical Reports Server (NTRS)

    Callaghan, Edmund E; Coles, Willard D

    1957-01-01

    An experimental investigation was conducted to study and compare the acoustic radiation of air jets and jet engines. A number of different nozzle-exit shapes were studied with air jets to determine the effect of exit shape on noise generation. Circular, square, rectangular, and elliptical convergent nozzles and convergent-divergent and plug nozzles were investigated. The spectral distributions of the sound power for the engine and the air jet were in good agreement for the case where the engine data were not greatly affected by reflection or jet interference effects. Such power spectra for a subsonic or slightly choked engine or air jet show that the peaks of the spectra occur at a Strouhal number of 0.3.

  15. Jet Transport Rejected Takeoffs.

    DTIC Science & Technology

    1977-02-01

    r _ _ _ _ _ _ N AD—A05 6 032 FEDERAL AVIATIO N ADMINISTRATION WASHINGTON 0 C FLIGHT—ETC FIG 1/2 ~,JET TRANSPORT REJECTED TAKEOFFS • (U)FED 77 0 S...AF~~16O-77-2 FOR FURTHER IRAN JET TRANSPORT R&JECTED TAKEDFFS DAVID W. OSTROWSKILI~~ H c ,~ ~~~~ C ...) ~~~~ O~ —1 w DDU FEB~JARY 1977U... FINAL...Pag. .po ,t No. 2 C.o.,,nm.rr, A c c . s s on No . 3. R.c ,pr. ns s Cat alog No. AFS-16~~-77-2_ j

  16. Plasma jet takes off.

    PubMed Central

    Frazer, L

    1999-01-01

    Thanks to a series of joint research projects by Los Alamos National Laboratory, Beta Squared of Allen, Texas, and the University of California at Los Angeles, there is now a more environmentally sound method for cleaning semiconductor chips that may also be effective in cleaning up chemical, bacterial, and nuclear contaminants. The Atmospheric Pressure Plasma Jet uses a type of ionized gas called plasma to clean up contaminants by binding to them and lifting them away. In contrast to the corrosive acids and chemical solvents traditionally used to clean semiconductor chips, the jet oxidizes contaminants, producing only benign gaseous by-products such as oxygen and carbon dioxide. The new technology is also easy to transport, cleans thoroughly and quickly, and presents no hazards to its operators. PMID:10417375

  17. SparkJet Efficiency

    NASA Technical Reports Server (NTRS)

    Golbabaei-Asl, Mona; Knight, Doyle; Anderson, Kellie; Wilkinson, Stephen

    2013-01-01

    A novel method for determining the thermal efficiency of the SparkJet is proposed. A SparkJet is attached to the end of a pendulum. The motion of the pendulum subsequent to a single spark discharge is measured using a laser displacement sensor. The measured displacement vs time is compared with the predictions of a theoretical perfect gas model to estimate the fraction of the spark discharge energy which results in heating the gas (i.e., increasing the translational-rotational temperature). The results from multiple runs for different capacitances of c = 3, 5, 10, 20, and 40 micro-F show that the thermal efficiency decreases with higher capacitive discharges.

  18. Jet Engine Noise Reduction

    DTIC Science & Technology

    2009-04-01

    Aeropropulsion Division, NASA Glenn Professor Parviz Moin, Ph.D. Director, Center for Turbulence Research, Stanford University Executive Secretary Mr. William J...Supersonic Jet Noise Prof. Parviz Moin, Stanford University 59 Versatile Affordable Advanced Turbine Engines (VAATE) Overview Dr. Larry Burns, AFRL...NASA Glenn Professor Parviz Moin, Ph.D. Director, Center for Turbulence Research, Stanford University Executive Secretary Mr. William J. Voorhees Head

  19. Alternative jet aircraft fuels

    NASA Technical Reports Server (NTRS)

    Grobman, J.

    1979-01-01

    Potential changes in jet aircraft fuel specifications due to shifts in supply and quality of refinery feedstocks are discussed with emphasis on the effects these changes would have on the performance and durability of aircraft engines and fuel systems. Combustion characteristics, fuel thermal stability, and fuel pumpability at low temperature are among the factors considered. Combustor and fuel system technology needs for broad specification fuels are reviewed including prevention of fuel system fouling and fuel system technology for fuels with higher freezing points.

  20. Jet-Lag Syndrome

    DTIC Science & Technology

    2002-11-01

    around one third of travellers do not experience jet lag. In particular sleep disturbance is experienced by around 78% of subjects after a...transmeridian flight whereas after 3 nights only around 30% of subjects experienced disturbance. In another study 40% of subjects reported subjective weakness...reductions in SWS and REM sleep may be present. After westward flights the sleep disturbance may only last for two or three days. Sleep quality is

  1. Ram jet engine

    SciTech Connect

    Crispin, B.; Pohl, W.D.; Thomaier, D.; Voss, N.

    1983-11-29

    In a ram jet engine, a tubular combustion chamber is divided into a flame chamber followed by a mixing chamber. The ram air is supplied through intake diffusers located on the exterior of the combustion chamber. The intake diffusers supply combustion air directly into the flame chamber and secondary air is conveyed along the exterior of the combustion chambers and then supplied directly into the mixing chamber.

  2. Rare variant testing across methods and thresholds using the multi-kernel sequence kernel association test (MK-SKAT).

    PubMed

    Urrutia, Eugene; Lee, Seunggeun; Maity, Arnab; Zhao, Ni; Shen, Judong; Li, Yun; Wu, Michael C

    Analysis of rare genetic variants has focused on region-based analysis wherein a subset of the variants within a genomic region is tested for association with a complex trait. Two important practical challenges have emerged. First, it is difficult to choose which test to use. Second, it is unclear which group of variants within a region should be tested. Both depend on the unknown true state of nature. Therefore, we develop the Multi-Kernel SKAT (MK-SKAT) which tests across a range of rare variant tests and groupings. Specifically, we demonstrate that several popular rare variant tests are special cases of the sequence kernel association test which compares pair-wise similarity in trait value to similarity in the rare variant genotypes between subjects as measured through a kernel function. Choosing a particular test is equivalent to choosing a kernel. Similarly, choosing which group of variants to test also reduces to choosing a kernel. Thus, MK-SKAT uses perturbation to test across a range of kernels. Simulations and real data analyses show that our framework controls type I error while maintaining high power across settings: MK-SKAT loses power when compared to the kernel for a particular scenario but has much greater power than poor choices.

  3. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.

    PubMed

    Dorsey, B D; McDonough, C; McDaniel, S L; Levin, R B; Newton, C L; Hoffman, J M; Darke, P L; Zugay-Murphy, J A; Emini, E A; Schleif, W A; Olsen, D B; Stahlhut, M W; Rutkowski, C A; Kuo, L C; Lin, J H; Chen, I W; Michelson, S R; Holloway, M K; Huff, J R; Vacca, J P

    2000-09-07

    Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of acquired immune-deficiency syndrome (AIDS). However, the emergence of viral resistance, demanding treatment protocols, and adverse side effects have exposed the urgent need for a second generation of HIV protease inhibitors. The continued exploration of our hydroxylaminepentanamide (HAPA) transition-state isostere series of HIV protease inhibitors, which initially resulted in the identification of Crixivan (indinavir sulfate, MK-639, L-735,524), has now yielded MK-944a (L-756,423). This compound is potent, is selective, and competitively inhibits HIV-1 PR with a K(i) value of 0.049 nM. It stops the spread of the HIV(IIIb)-infected MT4 lymphoid cells at 25.0-50.0 nM, even in the presence of alpha(1) acid glycoprotein, human serum albumin, normal human serum, or fetal bovine serum. MK-944a has a longer half-life in several animal models (rats, dogs, and monkeys) than indinavir sulfate and is currently in advanced human clinical trials.

  4. A 10 mK scanning tunneling microscope operating in ultra high vacuum and high magnetic fields.

    PubMed

    Assig, Maximilian; Etzkorn, Markus; Enders, Axel; Stiepany, Wolfgang; Ast, Christian R; Kern, Klaus

    2013-03-01

    We present design and performance of a scanning tunneling microscope (STM) that operates at temperatures down to 10 mK providing ultimate energy resolution on the atomic scale. The STM is attached to a dilution refrigerator with direct access to an ultra high vacuum chamber allowing in situ sample preparation. High magnetic fields of up to 14 T perpendicular and up to 0.5 T parallel to the sample surface can be applied. Temperature sensors mounted directly at the tip and sample position verified the base temperature within a small error margin. Using a superconducting Al tip and a metallic Cu(111) sample, we determined an effective temperature of 38 ± 1 mK from the thermal broadening observed in the tunneling spectra. This results in an upper limit for the energy resolution of ΔE = 3.5 kBT = 11.4 ± 0.3 μeV. The stability between tip and sample is 4 pm at a temperature of 15 mK as demonstrated by topography measurements on a Cu(111) surface.

  5. A 10Â mK scanning tunneling microscope operating in ultra high vacuum and high magnetic fields

    NASA Astrophysics Data System (ADS)

    Assig, Maximilian; Etzkorn, Markus; Enders, Axel; Stiepany, Wolfgang; Ast, Christian R.; Kern, Klaus

    2013-03-01

    We present design and performance of a scanning tunneling microscope (STM) that operates at temperatures down to 10 mK providing ultimate energy resolution on the atomic scale. The STM is attached to a dilution refrigerator with direct access to an ultra high vacuum chamber allowing in situ sample preparation. High magnetic fields of up to 14 T perpendicular and up to 0.5 T parallel to the sample surface can be applied. Temperature sensors mounted directly at the tip and sample position verified the base temperature within a small error margin. Using a superconducting Al tip and a metallic Cu(111) sample, we determined an effective temperature of 38 ± 1 mK from the thermal broadening observed in the tunneling spectra. This results in an upper limit for the energy resolution of ΔE = 3.5kBT = 11.4 ± 0.3 μeV. The stability between tip and sample is 4 pm at a temperature of 15 mK as demonstrated by topography measurements on a Cu(111) surface.

  6. Latent inhibition in rats neonatally treated chronically with MK-801: differential effects on conditioned taste aversion and conditioned emotional response.

    PubMed

    Niikura, Ryo; Nozawa, Takashi; Yamada, Kazuo; Kato, Katsunori; Ichitani, Yukio

    2015-04-15

    Chronic neonatal blockade of N-methyl-d-aspartate (NMDA) receptors produces various abnormal behaviors in adulthood animals. This study investigated the effects of neonatal treatment chronically with MK-801 in rats on the preexposure-induced retardation of CS-US association, i.e. latent inhibition (LI), of two aversive classical conditioning tasks in adulthood. In conditioned taste aversion (CTA) using sucrose taste and LiCl, neonatal chronic MK-801 (0.4 mg/kg twice/day) treatment attenuated the inhibitory effect of sucrose preexposure on the aversive conditioning, although the treatment did not affect CTA conditioning itself. On the other hand, in conditioned emotional response (CER) using tone and electrical foot shock, rats neonatally treated with MK-801 showed the same degree of inhibitory effect of tone preexposure on the aversive conditioning compared with neonatally vehicle-treated rats, and also showed the same level of CER conditioning itself. Thus, the effect of chronic neonatal blockade of NMDA receptors on the LI of classical conditioning in adulthood was differentiated by the task employed. Results suggest that LI of CTA paradigm compared with that of CER is more sensitive to abnormal development after chronic neonatal blockade of NMDA receptors as an index of cognitive/attentional deficits caused by the treatment.

  7. Activation of Macrophages by Exopolysaccharide Produced by MK1 Bacterial Strain Isolated from Neungee Mushroom, Sarcodon aspratus

    PubMed Central

    Im, Sun-A; Wang, Wenxia; Lee, Chong-Kil

    2010-01-01

    Background The MK1 strain, a novel bacterial isolate from soft-rotten tissue of the Neungee mushroom, produces copious amounts of exopolysaccharide (EPS) in a dextrose minimal medium. This study examined the molecular characteristics and immunomodulatory activity of MK1 EPS. Methods The EPS in the culture supernatant was purified by cold ethanol precipitation, and characterized by SDS-PAGE/silver staining and Bio-HPLC. The immunomodulatory activities of the EPS were examined using the mouse monocytic cell line, RAW 264.7 cells. Results The molecular weights of the purified EPS were rather heterogeneous, ranging from 10.6 to 55 kDa. The EPS was composed of glucose, rhamnose, mannose, galactose, and glucosamine at an approximate molar ratio of 1.00:0.8:0.71:0.29:0.21. EPS activated the RAW cells to produce cytokines, such as TNF-α and IL-1β, and nitric oxide (NO). EPS also induced the expression of co-stimulatory molecules, such as B7-1, B7-2 and ICAM-1, and increased the phagocytic activity. The macrophage-activating activity of EPS was not due to endotoxin contamination because the treatment of EPS with polymyin B did not reduce the macrophage-activating activity. Conclusion The EPS produced from the MK1 strain exerts macrophage-activating activity. PMID:21286384

  8. Isolation, characterization and biological evaluation of bioactive metabolites from Nocardia levis MK-VL_113.

    PubMed

    Kavitha, Alapati; Prabhakar, Peddikotla; Narasimhulu, Manchala; Vijayalakshmi, Muvva; Venkateswarlu, Yenamandra; Rao, Karanam Venkateswara; Raju, Venkata Balaraju Subba

    2010-03-31

    An Actinomycete isolate found to be prominent in the laterite soils of Acharya Nagarjuna University (ANU) Campus, Guntur was identified as Nocardia levis MK-VL_113 by 16S rRNA analysis. Cultural, morphological and physiological characteristics of the strain were recorded. Screening of secondary metabolites obtained from 4-day old culture broth of the strain led to the isolation of two fractions active against a wide variety of Gram-positive, Gram-negative bacteria and fungi. The structure of the first active fraction was elucidated using FT-IR, EI-MS, (1)H NMR and (13)C NMR spectra and identified as 1-phenylbut-3-ene-2-ol which is first time reported as a natural product. The compound exhibited good antimicrobial potential against the opportunistic and pathogenic bacteria and fungi. The antifungal activity of the strain and its metabolite were further confirmed with in vitro and in vivo studies. Evidence for the antagonism of the strain against Fusarium oxysporum, causing wilt disease in sorghum was demonstrated by the formation of inhibition zone in in vitro plate assay and reduction in the incidence of wilt of sorghum plants by using a green house trial. Analysis of the rhizosphere soil extracts by high performance liquid chromatography also demonstrated the production of the compound by the strain under in vivo conditions. As compared to the commercial fungicide mancozeb, the bioactive compound, 1-phenylbut-3-ene-2-ol was highly effective in controlling wilt of sorghum. Besides, the partially purified second fraction (PPF) subjected to gas chromatography-mass spectrometry revealed the presence of phenylethyl alcohol, dibutyl phthalate and 1,2-benzenedicarboxylic acid, 3-nitro.

  9. Machine learning methods predict locomotor response to MK-801 in mouse models of down syndrome.

    PubMed

    Nguyen, Cao D; Costa, Alberto C S; Cios, Krzysztof J; Gardiner, Katheleen J

    2011-03-01

    Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is a common genetic cause of cognitive impairment. This disorder results from the overexpression of HSA21 genes and the resulting perturbations in many molecular pathways and cellular processes. Knowledge-based identification of targets for pharmacotherapies will require defining the most critical protein abnormalities among these many perturbations. Here the authors show that using the Ts65Dn and Ts1Cje mouse models of DS, which are trisomic for 88 and 69 reference protein coding genes, respectively, a simple linear Naïve Bayes classifier successfully predicts behavioral outcome (level of locomotor activity) in response to treatment with the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Input to the Naïve Bayes method were simple protein profiles generated from cortex and output was locomotor activity binned into three levels: low, medium, and high. When Feature Selection was used with the Naïve Bayes method, levels of three HSA21 and two non-HSA21 protein features were identified as making the most significant contributions to activity level. Using these five features, accuracies of up to 88% in prediction of locomotor activity were achieved. These predictions depend not only on genotype-specific differences but also on within-genotype individual variation in levels of molecular and behavioral parameters. With judicious choice of pathways and components, a similar approach may be useful in analysis of more complex behaviors, including those associated with learning and memory, and may facilitate identification of novel targets for pharmacotherapeutics.

  10. Measurement of the inclusive jet cross section at the Fermilab Tevatron p pmacr collider using a cone-based jet algorithm

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Akimoto, T.; Albrow, M. G.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Azzurri, P.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Bartsch, V.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Bednar, P.; Beecher, D.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Beringer, J.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bolla, G.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Calancha, C.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Choudalakis, G.; Chuang, S. H.; Chung, K.; Chung, W. H.; Chung, Y. S.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Copic, K.; Cordelli, M.; Cortiana, G.; Cox, D. J.; Crescioli, F.; Cuenca Almenar, C.; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lorenzo, G.; Dell'Orso, M.; Deluca, C.; Demortier, L.; Deng, J.; Deninno, M.; Derwent, P. F.; di Giovanni, G. P.; Dionisi, C.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Donini, J.; Dorigo, T.; Dube, S.; Efron, J.; Elagin, A.; Erbacher, R.; Errede, D.; Errede, S.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Genser, K.; Gerberich, H.; Gerdes, D.; Gessler, A.; Giagu, S.; Giakoumopoulou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; Guimaraes da Costa, J.; Gunay-Unalan, Z.; Haber, C.; Hahn, K.; Hahn, S. R.; Halkiadakis, E.; Han, B.-Y.; Han, J. Y.; Handler, R.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harper, S.; Harr, R. F.; Harris, R. M.; Hartz, M.; Hatakeyama, K.; Hauser, J.; Hays, C.; Heck, M.; Heijboer, A.; Heinemann, B.; Heinrich, J.; Henderson, C.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Huffman, B. T.; Hughes, R. E.; Husemann, U.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jayatilaka, B.; Jeon, E. J.; Jha, M. K.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Keung, J.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Knuteson, B.; Ko, B. R.; Koay, S. A.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Krop, D.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kubo, T.; Kuhr, T.; Kulkarni, N. P.; Kurata, M.; Kusakabe, Y.; Kwang, S.; Laasanen, A. T.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, E.; Lee, S. W.; Leone, S.; Lewis, J. D.; Lin, C. S.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, C.; Liu, T.; Lockyer, N. S.; Loginov, A.; Loreti, M.; Lovas, L.; Lu, R.-S.; Lucchesi, D.; Lueck, J.; Luci, C.; Lujan, P.; Lukens, P.; Lungu, G.; Lyons, L.; Lys, J.; Lysak, R.; Lytken, E.; Mack, P.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maki, T.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Maruyama, T.; Mastrandrea, P.; Masubuchi, T.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzione, A.; Merkel, P.; Mesropian, C.; Miao, T.; Miladinovic, N.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Morlok, J.; Movilla Fernandez, P.; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Mumford, R.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Nagano, A.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Necula, V.; Neu, C.; Neubauer, M. S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Osterberg, K.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramonov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Poukhov, O.; Pounder, N.; Prakoshyn, F.; Pronko, A.; Proudfoot, J.; Ptohos, F.; Pueschel, E.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Reisert, B.; Rekovic, V.; Renton, P.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rodriguez, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Saltó, O.; Santi, L.; Sarkar, S.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Scheidle, T.; Schlabach, P.; Schmidt, A.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scott, A. L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sfyrla, A.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Sherman, D.; Shimojima, M.; Shiraishi, S.; Shochet, M.; Shon, Y.; Shreyber, I.; Sidoti, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soha, A.; Somalwar, S.; Sorin, V.; Spalding, J.; Spreitzer, T.; Squillacioti, P.; Stanitzki, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Stuart, D.; Suh, J. S.; Sukhanov, A.; Suslov, I.; Suzuki, T.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tecchio, M.; Teng, P. K.; Terashi, K.; Thom, J.; Thompson, A. S.; Thompson, G. A.; Thomson, E.; Tipton, P.; Tiwari, V.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Tourneur, S.; Tu, Y.; Turini, N.; Ukegawa, F.; Vallecorsa, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Veszpremi, V.; Vidal, M.; Vidal, R.; Vila, I.; Vilar, R.; Vine, T.; Vogel, M.; Volobouev, I.; Volpi, G.; Würthwein, F.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner-Kuhr, J.; Wagner, W.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wright, T.; Wu, X.; Wynne, S. M.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanello, L.; Zanetti, A.; Zaw, I.; Zhang, X.; Zheng, Y.; Zucchelli, S.

    2008-09-01

    We present a measurement of the inclusive jet cross section in p pmacr collisions at s=1.96TeV based on data collected by the CDF II detector with an integrated luminosity of 1.13fb-1. The measurement was made using the cone-based midpoint jet clustering algorithm in the rapidity region of |y|<2.1. The results are consistent with next-to-leading-order perturbative QCD predictions based on recent parton distribution functions (PDFs), and are expected to provide increased precision in PDFs at high parton momentum fraction x. The results are also compared to the recent inclusive jet cross section measurement using the kT jet clustering algorithm, and we find that the ratio of the cross sections measured with the two algorithms is in agreement with theoretical expectations over a large range of jet transverse momentum and rapidity.

  11. Small-scale chromospheric jets above a sunspot light bridge

    NASA Astrophysics Data System (ADS)

    Louis, Rohan E.; Beck, Christian; Ichimoto, Kiyoshi

    2014-07-01

    Context. The chromosphere above sunspot umbrae and penumbrae shows several different types of fast dynamic events such as running penumbral waves, umbral flashes, and penumbral microjets. Aims: The aim of this paper is to identify the physical driver responsible for the dynamic and small-scale chromospheric jets above a sunspot light bridge. Methods: High-resolution broadband filtergrams of active region NOAA 11271 in Ca ii H and G band were obtained with the Solar Optical Telescope on board Hinode. We identified the jets in the Ca ii H images using a semi-automatic routine and determined their length and orientation. We applied local correlation tracking (LCT) to the G-band images to obtain the photospheric horizontal velocity field. The magnetic field topology was derived from a Milne-Eddington inversion of a simultaneous scan with the Spectropolarimeter. Results: The chromospheric jets consist of a bright, triangular-shaped blob that lies on the light bridge, while the apex of this blob extends into a spike-like structure that is bright against the dark umbral background. Most of the jets have apparent lengths of less than 1000 km and about 30% of the jets have lengths between 1000-1600 km. The jets are oriented within ±35° to the normal of the spine of the light bridge. Most of them are clustered near the central part of the light bridge within a 2'' area. The jets are seen to move rapidly along the light bridge and many of them cannot be identified in successive images taken with a 2 min cadence. The jets are primarily located on one side of the light bridge and are directed into the umbral core. The Stokes profiles at or close to the location of the blobs on the LB exhibit both a significant net circular polarization and multiple components, including opposite-polarity lobes. The magnetic field diverges from the light bridge towards the umbral cores that it separates. The LCT reveals that in the photosphere there is a predominantly uni-directional flow with

  12. Arc jet diagnostics tests

    NASA Technical Reports Server (NTRS)

    Willey, Ronald J.

    1989-01-01

    Two objectives were addressed during a 10 week 1988 NASA/ASEE summer faculty fellowship at the Johnson Space Center Atmospheric Reentry Materials Structures Evaluation Facility (ARMSEF). These objectives were the evaluation of mass spectrometry for the measurement of atomic and molecular species in an arc jet environment, and the determination of atomic recombination coefficients for reaction cured glass (RCG) coated high temperature surface insulation (HRSI) materials subjected to simulated reentry conditions. Evaluation of mass spectrometry for the measurement of atomic and molecular species provided some of the first measurements of point compositions in arc jet tunnel environments. A major objective of this project centered around the sampling residence time. A three staged vacuum sampling system pulled the molecules and atoms from the arc jet to a quadrupole ionization mass spectrometer in 400 milliseconds. Conditions investigated included a composition survey across the nozzle exit at 3 cm z-distance from the nozzle exit for 3 different currents. Also, a point composition survey was taken around a shock created by the presence of a blunt body.

  13. JET Noise Prediction

    NASA Technical Reports Server (NTRS)

    Goldstein, M. E.; Leib, S. J.

    2007-01-01

    Aerodynamic noise prediction has been an important and challenging research area since James Lighthill first introduced his Acoustic Analogy Approach over fifty years ago. This talk attempts to provide a unified framework for the subsequent theoretical developments in this field. It assumes that there is no single approach that is optimal in all situations and uses the framework as a basis for discussing the strengths weaknesses of the various approaches to this topic. But the emphasis here will be on the important problem of predicting the noise from high speed air jets. Specific results will presented for round jets in the 0.5 to 1.4 Mach number range and compared with experimental data taken on the Glenn SHAR rig. It is demonstrated that non-parallel mean flow effects play an important role in predicting the noise at the supersonic Mach numbers. The results explain the failure of previous attempts based on the parallel flow Lilley model (which has served as the foundation for most jet noise analyses during past two decades).

  14. Longitudinal Variation and Waves in Jupiter's South Equatorial Wind Jet

    NASA Technical Reports Server (NTRS)

    Simon-Miller, A. A.; Rogers, John H.; Gierasch, Peter J.; Choi, David; Allison, Michael; Adamoli, Gianluigi; Mettig, Hans-Joerg

    2012-01-01

    We have conducted a detailed study of the cloud features in the strong southern equatorial wind jet near 7.5 S planetographic latitude. To understand the apparent variations in average zonal wind jet velocity at this latitude [e.g.. 1,2,3], we have searched for variations iIi both feature latitude and velocity with longitude and time. In particular, we focused on the repetitive chevron-shaped dark spots visible on most dates and the more transient large anticyclonic system known as the South Equatorial Disturbance (SED). These small dark spots are interpreted as cloud holes, and are often used as material tracers of the wind field.

  15. Rapid Confined Mixing Using Transverse Jets Part 2: Multiple Jets

    NASA Astrophysics Data System (ADS)

    Forliti, David; Salazar, David

    2012-11-01

    An experimental study has been conducted at the Air Force Research Laboratory at Edwards Air Force Base to investigate the properties of confined mixing devices that employ transverse jets. The experiment considers the mixing of water with a mixture of water and fluorescein, and planar laser induced fluorescence was used to measure instantaneous mixture fraction distributions in the cross section view. Part one of this study presents the scaling law development and results for a single confined transverse jet. Part two will describe the results of configurations including multiple transverse jets. The different regimes of mixing behavior, ranging from under to overpenetration of the transverse jets, are characterized in terms of a new scaling law parameter presented in part one. The level of unmixedness, a primary metric for mixing device performance, is quantified for different jet diameters, number of jets, and relative flow rates. It is apparent that the addition of a second transverse jet provides enhanced scalar uniformity in the main pipe flow cross section compared to a single jet. Three and six jet configurations also provide highly uniform scalar distributions. Turbulent scalar fluctuation intensities, spectral features, and spatial eigenfunctions using the proper orthogonal decomposition will be presented. Distribution A: Public Release, Public Affairs Clearance Number: 12656.

  16. Synchrotron and inverse-Compton emission from blazar jets - III. Compton-dominant blazars

    NASA Astrophysics Data System (ADS)

    Potter, William J.; Cotter, Garret

    2013-05-01

    In this paper, we develop the extended jet model of Potter & Cotter to model the simultaneous multiwavelength spectra of six Compton-dominant blazars. We include an accelerating parabolic base transitioning to a slowly decelerating conical jet with a geometry set by observations of M87 and consistent with simulations and theory. We investigate several jet models and find that the optically thick to thin synchrotron break in the radio spectrum requires the jet to first come into equipartition at large distances along the jet, consistent with the observed transition from parabolic to conical at 105Rs in the jet of M87. We confirm this result analytically and calculate the expected frequency core-shift relations for the models under consideration. We find that a parabolic jet transitioning to a ballistic conical jet at 105Rs, which starts in equipartition and becomes more particle dominated at larger distances, fits the multiwavelength data of the six blazars well, whilst an adiabatic equipartition conical section requires very large bulk Lorentz factors to reproduce the Compton dominance of the blazars. We find that all these blazars require high power (>1039 W), high bulk Lorentz factor (>20) jets observed close to the line of sight (<2°) as we expect from the blazar sequence and consistent with the results from Paper II. The inverse-Compton emission in our fits is due to inverse-Compton scattering of high-redshift cosmic microwave background photons at large distances along the jet due to the high bulk Lorentz factors of the jets. We postulate a new interpretation of the blazar sequence based on the radius of the transition region of the jet (where the jet is brightest in synchrotron emission) scaling linearly with black hole mass.

  17. The effects of the stellar wind and orbital motion on the jets of high-mass microquasars

    NASA Astrophysics Data System (ADS)

    Bosch-Ramon, V.; Barkov, M. V.

    2016-05-01

    Context. High-mass microquasar jets propagate under the effect of the wind from the companion star, and the orbital motion of the binary system. The stellar wind and the orbit may be dominant factors determining the jet properties beyond the binary scales. Aims: This is an analytical study, performed to characterise the effects of the stellar wind and the orbital motion on the jet properties. Methods: Accounting for the wind thrust transferred to the jet, we derive analytical estimates to characterise the jet evolution under the impact of the stellar wind. We include the Coriolis force effect, induced by orbital motion and enhanced by the wind's presence. Large-scale evolution of the jet is sketched, accounting for wind-to-jet thrust transfer, total energy conservation, and wind-jet flow mixing. Results: If the angle of the wind-induced jet bending is larger than its half-opening angle, the following is expected: (i) a strong recollimation shock; (ii) bending against orbital motion, caused by Coriolis forces and enhanced by the wind presence; and (iii) non-ballistic helical propagation further away. Even if disrupted, the jet can re-accelerate due to ambient pressure gradients, but wind entrainment can weaken this acceleration. On large scales, the opening angle of the helical structure is determined by the wind-jet thrust relation, and the wind-loaded jet flow can be rather slow. Conclusions: The impact of stellar winds on high-mass microquasar jets can yield non-ballistic helical jet trajectories, jet partial disruption and wind mixing, shocks, and possibly non-thermal emission. Among other observational diagnostics, such as radiation variability at any band, the radio morphology on milliarcsecond scales can be informative on the wind-jet interaction.

  18. 30 CFR 57.7801 - Jet drills.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a)...

  19. 30 CFR 57.7801 - Jet drills.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a)...

  20. 30 CFR 56.7801 - Jet drills.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system...

  1. 30 CFR 56.7801 - Jet drills.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system...

  2. 30 CFR 57.7801 - Jet drills.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a)...

  3. 30 CFR 56.7801 - Jet drills.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system...

  4. 30 CFR 56.7801 - Jet drills.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system...

  5. 30 CFR 56.7801 - Jet drills.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Jet drills. 56.7801 Section 56.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing § 56.7801 Jet drills. Jet piercing drills shall be provided with— (a) A system...

  6. 30 CFR 57.7801 - Jet drills.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a)...

  7. 30 CFR 57.7801 - Jet drills.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Jet drills. 57.7801 Section 57.7801 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet Piercing Rotary Jet Piercing-Surface Only § 57.7801 Jet drills. Jet piercing drills shall be provided with: (a)...

  8. An innovative blazar classification based on radio jet kinematics

    NASA Astrophysics Data System (ADS)

    Hervet, O.; Boisson, C.; Sol, H.

    2016-07-01

    Context. Blazars are usually classified following their synchrotron peak frequency (νF(ν) scale) as high, intermediate, low frequency peaked BL Lacs (HBLs, IBLs, LBLs), and flat spectrum radio quasars (FSRQs), or, according to their radio morphology at large scale, FR I or FR II. However, the diversity of blazars is such that these classes seem insufficient to chart the specific properties of each source. Aims: We propose to classify a wide sample of blazars following the kinematic features of their radio jets seen in very long baseline interferometry (VLBI). Methods: For this purpose we use public data from the MOJAVE collaboration in which we select a sample of blazars with known redshift and sufficient monitoring to constrain apparent velocities. We selected 161 blazars from a sample of 200 sources. We identify three distinct classes of VLBI jets depending on radio knot kinematics: class I with quasi-stationary knots, class II with knots in relativistic motion from the radio core, and class I/II, intermediate, showing quasi-stationary knots at the jet base and relativistic motions downstream. Results: A notable result is the good overlap of this kinematic classification with the usual spectral classification; class I corresponds to HBLs, class II to FSRQs, and class I/II to IBLs/LBLs. We deepen this study by characterizing the physical parameters of jets from VLBI radio data. Hence we focus on the singular case of the class I/II by the study of the blazar BL Lac itself. Finally we show how the interpretation that radio knots are recollimation shocks is fully appropriate to describe the characteristics of these three classes.

  9. Measurement of Inclusive Jet Cross Sections in Z/γ*(→e+e-)+jets Production in pp¯ Collisions at s=1.96TeV

    NASA Astrophysics Data System (ADS)

    Aaltonen, T.; Adelman, J.; Akimoto, T.; Albrow, M. G.; Álvarez González, B.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Aoki, M.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Azzi-Bacchetta, P.; Azzurri, P.; Bacchetta, N.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Baroiant, S.; Bartsch, V.; Bauer, G.; Beauchemin, P.-H.; Bedeschi, F.; Bednar, P.; Behari, S.; Bellettini, G.; Bellinger, J.; Belloni, A.; Benjamin, D.; Beretvas, A.; Beringer, J.; Berry, T.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bolla, G.; Bolshov, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Choudalakis, G.; Chuang, S. H.; Chung, K.; Chung, W. H.; Chung, Y. S.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Cooper, B.; Copic, K.; Cordelli, M.; Cortiana, G.; Crescioli, F.; Cuenca Almenar, C.; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; de Cecco, S.; Deisher, A.; de Lentdecker, G.; de Lorenzo, G.; Dell'Orso, M.; Demortier, L.; Deng, J.; Deninno, M.; de Pedis, D.; Derwent, P. F.; di Giovanni, G. P.; Dionisi, C.; di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Donini, J.; Dorigo, T.; Dube, S.; Efron, J.; Erbacher, R.; Errede, D.; Errede, S.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Forrester, S.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Gerberich, H.; Gerdes, D.; Giagu, S.; Giakoumopolou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; Guimaraes da Costa, J.; Gunay-Unalan, Z.; Haber, C.; Hahn, K.; Hahn, S. R.; Halkiadakis, E.; Hamilton, A.; Han, B.-Y.; Han, J. Y.; Handler, R.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harper, S.; Harr, R. F.; Harris, R. M.; Hartz, M.; Hatakeyama, K.; Hauser, J.; Hays, C.; Heck, M.; Heijboer, A.; Heinemann, B.; Heinrich, J.; Henderson, C.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S.-C.; Huffman, B. T.; Hughes, R. E.; Husemann, U.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; Iyutin, B.; James, E.; Jayatilaka, B.; Jeans, D.; Jeon, E. J.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Kerzel, U.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Klute, M.; Knuteson, B.; Ko, B. R.; Koay, S. A.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kraus, J.; Kreps, M.; Kroll, J.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kubo, T.; Kuhlmann, S. E.; Kuhr, T.; Kulkarni, N. P.; Kusakabe, Y.; Kwang, S.; Laasanen, A. T.; Lai, S.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; Lecompte, T.; Lee, J.; Lee, J.; Lee, Y. J.; Lee, S. W.; Lefèvre, R.; Leonardo, N.; Leone, S.; Levy, S.; Lewis, J. D.; Lin, C.; Lin, C. S.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, T.; Lockyer, N. S.; Loginov, A.; Loreti, M.; Lovas, L.; Lu, R.-S.; Lucchesi, D.; Lueck, J.; Luci, C.; Lujan, P.; Lukens, P.; Lungu, G.; Lyons, L.; Lys, J.; Lysak, R.; Lytken, E.; Mack, P.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maki, T.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, M.; Martin, V.; Martínez, M.; Martínez-Ballarín, R.; Maruyama, T.; Mastrandrea, P.; Masubuchi, T.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzemer, S.; Menzione, A.; Merkel, P.; Mesropian, C.; Messina, A.; Miao, T.; Miladinovic, N.; Miles, J.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M.; Movilla Fernandez, P.; Mülmenstädt, J.; Mukherjee, A.; Muller, Th.; Mumford, R.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Nagano, A.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Necula, V.; Neu, C.; Neubauer, M. S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Oldeman, R.; Orava, R.; Osterberg, K.; Pagan Griso, S.; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramonov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Piedra, J.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Portell, X.; Poukhov, O.; Pounder, N.; Prakoshyn, F.; Pronko, A.; Proudfoot, J.; Ptohos, F.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Reisert, B.; Rekovic, V.; Renton, P.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Salamanna, G.; Saltó, O.; Santi, L.; Sarkar, S.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Scheidle, T.; Schlabach, P.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scott, A. L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sfyria, A.; Shalhout, S. Z.; Shapiro, M. D.; Shears, T.; Shepard, P. F.; Sherman, D.; Shimojima, M.; Shochet, M.; Shon, Y.; Shreyber, I.; Sidoti, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soderberg, M.; Soha, A.; Somalwar, S.; Sorin, V.; Spalding, J.; Spinella, F.; Spreitzer, T.; Squillacioti, P.; Stanitzki, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Stuart, D.; Suh, J. S.; Sukhanov, A.; Sun, H.; Suslov, I.; Suzuki, T.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tecchio, M.; Teng, P. K.; Terashi, K.; Thom, J.; Thompson, A. S.; Thompson, G. A.; Thomson, E.; Tipton, P.; Tiwari, V.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Tourneur, S.; Trischuk, W.; Tu, Y.; Turini, N.; Ukegawa, F.; Uozumi, S.; Vallecorsa, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vázquez, F.; Velev, G.; Vellidis, C.; Veszpremi, V.; Vidal, M.; Vidal, R.; Vila, I.; Vilar, R.; Vine, T.; Vogel, M.; Volobouev, I.; Volpi, G.; Würthwein, F.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner-Kuhr, J.; Wagner, W.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wright, T.; Wu, X.; Wynne, S. M.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yamashita, T.; Yang, C.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanello, L.; Zanetti, A.; Zaw, I.; Zhang, X.; Zheng, Y.; Zucchelli, S.

    2008-03-01

    Inclusive jet cross sections in Z/γ* events, with Z/γ* decaying into an electron-positron pair, are measured as a function of jet transverse momentum and jet multiplicity in pp¯ collisions at s=1.96TeV with the upgraded Collider Detector at Fermilab in run II, based on an integrated luminosity of 1.7fb-1. The measurements cover the rapidity region |yjet|<2.1 and the transverse momentum range pTjet>30GeV/c. Next-to-leading order perturbative QCD predictions are in good agreement with the measured cross sections.

  10. The formation of interstellar jets

    NASA Technical Reports Server (NTRS)

    Tenorio-Tagle, G.; Canto, J.; Rozyczka, M.

    1988-01-01

    The formation of interstellar jets by convergence of supersonic conical flows and the further dynamical evolution of these jets are investigated theoretically by means of numerical simulations. The results are presented in extensive graphs and characterized in detail. Strong radiative cooling is shown to result in jets with Mach numbers 2.5-29 propagating to lengths 50-100 times their original widths, with condensation of swept-up interstellar matter at Mach 5 or greater. The characteristics of so-called molecular outflows are well reproduced by the simulations of low-Mach-number and quasi-adiabatic jets.

  11. Jet penetration of high explosive

    SciTech Connect

    Poulsen, P

    1999-08-11

    It is found that a transition between two flow patterns takes place in thick HE targets. In this case, the jet will initially propagate into the HE at the same rate as into an inert material of the same density. The part of the jet that has stagnated and is flowing nearly co-axially with the incoming jet (but at a much lower speed) is being forced toward the surface of the incoming jet by the pressure of the reaction products but has not as yet made contact. After it makes contact, both axial and perpendicular momentum transfer takes place between the two jet components. After this transition, a new steady state will develop for the propagating jet, with the unperturbed front of the jet propagating at a slower rate than previously. The perturbed front of the jet is still propagating at or near the original rate, having had relatively little axial momentum exchange. However, it has acquired radial momentum and is spreading out as it is propagating; it is therefore becoming less capable of penetrating downstream targets. It is the unperturbed part of the jet that is capable of penetrating downstream targets. A calculational method for predicting this case is presented in this report.

  12. Microplasma jet at atmospheric pressure

    SciTech Connect

    Hong, Yong Cheol; Uhm, Han Sup

    2006-11-27

    A nitrogen microplasma jet operated at atmospheric pressure was developed for treating thermally sensitive materials. For example, the plasma sources in treatment of vulnerable biological materials must operate near the room temperature at the atmospheric pressure, without any risk of arcing or electrical shock. The microplasma jet device operated by an electrical power less than 10 W exhibited a long plasma jet of about 6.5 cm with temperature near 300 K, not causing any harm to human skin. Optical emission measured at the wide range of 280-800 nm indicated various reactive species produced by the plasma jet.

  13. Field of Flow About a Jet and Effect of Jets on Stability of Jet-Propelled Airplanes

    NASA Technical Reports Server (NTRS)

    Ribner, Herbert S.

    1946-01-01

    A theoretical investigation was conducted on jet-induced flow deviation. Analysis is given of flow inclination induced outside cold and hot jets and jet deflection caused by angle of attack. Applications to computation of effects of jet on longitudinal stability and trim are explained. Effect of jet temperature on flow inclination was found small when thrust coefficient is used as criterion for similitude. The average jet-induced downwash over tail plane was obtained geometrically.

  14. In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.

    PubMed

    Leiphrakpam, Premila D; Agarwal, Ekta; Mathiesen, Michelle; Haferbier, Katie L; Brattain, Michael G; Chowdhury, Sanjib

    2014-01-01

    The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906, a small molecule tyrosine kinase inhibitor on CRC cells. Xenograft study was performed on IGF-1R-dependent CRC cell lines for analyzing the antitumor activity of MK-0646 and OSI-906. Tumor proliferation and apoptosis were assessed using Ki67 and TUNEL assays, respectively. We also performed in vitro characterization of MK-0646 and OSI-906 treatment on CRC cells to identify mechanisms associated with drug-induced cell death. Exposure of the GEO and CBS tumor xenografts to MK-0646 or OSI-906 led to a decrease in tumor growth. TUNEL analysis showed an increase of approximately 45-55% in apoptotic cells in both MK-0646 and OSI-906 treated tumor samples. We report the novel finding that treatment with IGF-1R antagonists led to downregulation of X-linked inhibitor of apoptosis (XIAP) protein involved in cell survival and inhibition of cell death. In conclusion, IGF-1R antagonists (MK-0646 and OSI-906) demonstrated single agent inhibition of subcutaneous CRC xenograft growth. This was coupled to pro-apoptotic effects resulting in downregulation of XIAP and inhibition of cell survival. We report a novel mechanism by which MK-0646 and OSI-906 elicits cell death in vivo and in vitro. Moreover, these results indicate that MK-0646 and OSI-906 may be potential anticancer candidates for the treatment of patients with IGF-1R-dependent CRC.

  15. Afterbody Drag. Volume 2. Jet Interference Effects on Subsonic Boattail Drag.

    DTIC Science & Technology

    1980-06-01

    NUMBER hCP 8 E 0.4 0.02 00 6 0 3 4 5 6 z _DISTANCE FORWARD OF JET EXIT PLANE rj JET RADIUS Figure 8. The Effect of Free-Stream Mach Number on the...I2+2*G 1960 GO TO 2010 1965 I1=I1+4*F 1970 I2=I2+4*G 2010 NEXT 13 2011 X1=(13-1)*X8 2012 GOSUB 3000 2013 GOSUB 3500 2014 II=II+F 2015 12=I2+G 2016 II

  16. SYSTEMATIC MOTION OF FINE-SCALE JETS AND SUCCESSIVE RECONNECTION IN SOLAR CHROMOSPHERIC ANEMONE JET OBSERVED WITH THE SOLAR OPTICAL TELESCOPE/HINODE

    SciTech Connect

    Singh, K. A. P.; Nishida, K.; Shibata, K.; Isobe, H.

    2012-11-20

    The Solar Optical Telescope (SOT) on board Hinode allows observations with high spatiotemporal resolution and stable image quality. A {lambda}-shaped chromospheric anemone jet was observed in high resolution with SOT/Hinode. We found that several fine-scale jets were launched from one end of the footpoint to the other. These fine-scale jets ({approx}1.5-2.5 Mm) gradually move from one end of the footpoint to the other and finally merge into a single jet. This process occurs recurrently, and as time progresses the jet activity becomes more and more violent. The time evolution of the region below the jet in Ca II H filtergram images taken with SOT shows that various parts (or knots) appear at different positions. These bright knots gradually merge into each other during the maximum phase. The systematic motion of the fine-scale jets is observed when different knots merge into each other. Such morphology would arise due to the emergence of a three-dimensional twisted flux rope in which the axial component (or the guide field) appears in the later stages of the flux rope emergence. The partial appearance of the knots could be due to the azimuthal magnetic field that appears during the early stage of the flux rope emergence. If the guide field is strong and reconnection occurs between the emerging flux rope and an ambient magnetic field, this could explain the typical feature of systematic motion in chromospheric anemone jets.

  17. Systematic Motion of Fine-scale Jets and Successive Reconnection in Solar Chromospheric Anemone Jet Observed with the Solar Optical Telescope/Hinode

    NASA Astrophysics Data System (ADS)

    Singh, K. A. P.; Isobe, H.; Nishida, K.; Shibata, K.

    2012-11-01

    The Solar Optical Telescope (SOT) on board Hinode allows observations with high spatiotemporal resolution and stable image quality. A λ-shaped chromospheric anemone jet was observed in high resolution with SOT/Hinode. We found that several fine-scale jets were launched from one end of the footpoint to the other. These fine-scale jets (~1.5-2.5 Mm) gradually move from one end of the footpoint to the other and finally merge into a single jet. This process occurs recurrently, and as time progresses the jet activity becomes more and more violent. The time evolution of the region below the jet in Ca II H filtergram images taken with SOT shows that various parts (or knots) appear at different positions. These bright knots gradually merge into each other during the maximum phase. The systematic motion of the fine-scale jets is observed when different knots merge into each other. Such morphology would arise due to the emergence of a three-dimensional twisted flux rope in which the axial component (or the guide field) appears in the later stages of the flux rope emergence. The partial appearance of the knots could be due to the azimuthal magnetic field that appears during the early stage of the flux rope emergence. If the guide field is strong and reconnection occurs between the emerging flux rope and an ambient magnetic field, this could explain the typical feature of systematic motion in chromospheric anemone jets.

  18. Comparison of the MK-801-induced increase in non-rewarded appetitive responding with dopamine agonists and locomotor activity in rats.

    PubMed

    Davis-MacNevin, Parnell L; Dekraker, Jordan; LaDouceur, Liane; Holahan, Matthew R

    2013-09-01

    Systemic administration of the noncompetitive N-methyl-D-aspartate (NMDA)- receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. Evidence has shown that MK-801 increases the probability of operant responding during extinction, possibly modeling perseveration, as would be seen in patients with schizophrenia. This MK-801-induced behavioral perseveration is reversed by dopamine receptor antagonism. To further explore the role of dopamine in this behavioral change, the current study sought to determine if the MK-801-induced increase in non-rewarded operant responding could be mimicked by dopamine agonism and determine how it was related to locomotor activity. Male Long Evans rats were treated systemically with MK-801, cocaine, GBR12909 or apomorphine (APO) and given a single trial operant extinction session, followed by a separate assessment of locomotor activity. Both MK-801 (0.05 mg/kg) and cocaine (10 mg/kg) significantly increased responding during the extinction session and both increased horizontal locomotor activity. No dose of GBR-12909 (5, 10 or 20 mg/kg) was found to effect non-rewarded operant responding or locomotor activity. APO (0.05, 0.5, 2 or 5 mg/kg) treatment produced a dose-dependent decrease in both operant responding and locomotor activity. These results suggest the possibility that, rather than a primary influence of increased dopamine concentration on elevating bar-pressing responses during extinction, other neurotransmitter systems may be involved.

  19. Boosted Jets at the LHC

    NASA Astrophysics Data System (ADS)

    Larkoski, Andrew

    2015-04-01

    Jets are collimated streams of high-energy particles ubiquitous at any particle collider experiment and serve as proxy for the production of elementary particles at short distances. As the Large Hadron Collider at CERN continues to extend its reach to ever higher energies and luminosities, an increasingly important aspect of any particle physics analysis is the study and identification of jets, electroweak bosons, and top quarks with large Lorentz boosts. In addition to providing a unique insight into potential new physics at the tera-electron volt energy scale, high energy jets are a sensitive probe of emergent phenomena within the Standard Model of particle physics and can teach us an enormous amount about quantum chromodynamics itself. Jet physics is also invaluable for lower-level experimental issues including triggering and background reduction. It is especially important for the removal of pile-up, which is radiation produced by secondary proton collisions that contaminates every hard proton collision event in the ATLAS and CMS experiments at the Large Hadron Collider. In this talk, I will review the myriad ways that jets and jet physics are being exploited at the Large Hadron Collider. This will include a historical discussion of jet algorithms and the requirements that these algorithms must satisfy to be well-defined theoretical objects. I will review how jets are used in searches for new physics and ways in which the substructure of jets is being utilized for discriminating backgrounds from both Standard Model and potential new physics signals. Finally, I will discuss how jets are broadening our knowledge of quantum chromodynamics and how particular measurements performed on jets manifest the universal dynamics of weakly-coupled conformal field theories.

  20. Measurement of the Top Pair Production Cross Section in the Lepton + Jets Channel Using a Jet Flavor Discriminant

    DOE PAGES

    Aaltonen, T.

    2011-08-01

    We present a new method to measure the top quark pair production cross section and the background rates with data corresponding to an integrated luminosity of 2.7 fb-1 from pp¯ collisions at √s = 1.96 TeV collected with the CDF II Detector. We select events with a single electron or muon candidate, missing transverse energy, and at least one b-tagged jet. We perform a simultaneous fit to a jet flavor discriminant across nine samples defined by the number of jets and b-tags. An advantage of this approach is that many systematic uncertainties are measured in situ and inversely scale withmore » integrated luminosity. We measure a top cross section of σtt¯ = 7.64 ± 0.57 (stat + syst) ± 0.45 (luminosity) pb.« less

  1. Top quark mass measurement in the lepton + jets channel using a matrix element method and in situ jet energy calibration.

    PubMed

    Aaltonen, T; González, B Alvarez; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bauer, G; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Brisuda, A; Bromberg, C; Brucken, E; Bucciantonio, M; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Almenar, C Cuenca; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; De Cecco, S; De Lorenzo, G; Dell'Orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; da Costa, J Guimaraes; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hidas, D; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirby, M; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, Q; Liu, T; Lockwitz, S; Lockyer, N S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Fernandez, P Movilla; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Griso, S Pagan; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rubbo, F; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shreyber, I; Siegrist, J; Simonenko, A; Sinervo, P; Sissakian, A; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; Denis, R St; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Volobouev, I; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamaoka, J; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zucchelli, S

    2010-12-17

    A precision measurement of the top quark mass m(t) is obtained using a sample of tt events from pp collisions at the Fermilab Tevatron with the CDF II detector. Selected events require an electron or muon, large missing transverse energy, and exactly four high-energy jets, at least one of which is tagged as coming from a b quark. A likelihood is calculated using a matrix element method with quasi-Monte Carlo integration taking into account finite detector resolution and jet mass effects. The event likelihood is a function of m(t) and a parameter Δ(JES) used to calibrate the jet energy scale in situ. Using a total of 1087 events in 5.6 fb(-1) of integrated luminosity, a value of m(t)=173.0 ± 1.2 GeV/c(2) is measured.

  2. Measurement of the Top Pair Production Cross Section in the Lepton + Jets Channel Using a Jet Flavor Discriminant

    SciTech Connect

    Aaltonen, T.

    2011-08-01

    We present a new method to measure the top quark pair production cross section and the background rates with data corresponding to an integrated luminosity of 2.7 fb-1 from pp¯ collisions at √s = 1.96 TeV collected with the CDF II Detector. We select events with a single electron or muon candidate, missing transverse energy, and at least one b-tagged jet. We perform a simultaneous fit to a jet flavor discriminant across nine samples defined by the number of jets and b-tags. An advantage of this approach is that many systematic uncertainties are measured in situ and inversely scale with integrated luminosity. We measure a top cross section of σtt¯ = 7.64 ± 0.57 (stat + syst) ± 0.45 (luminosity) pb.

  3. Magnetic Untwisting in Solar Jets that Go into the Outer Corona in Polar Coronal Holes

    NASA Technical Reports Server (NTRS)

    Moore, Ronald L.; Sterling, Alphonse C.; Falconer, David A.

    2014-01-01

    We present results from 14 exceptionally high-reaching large solar jets observed in the polar coronal holes. EUV movies from SDO/AIA show that each jet is similar to many other similar-size and smaller jets that erupt in coronal holes, but each is exceptional in that it goes higher than most other jets, so high that it is observed in the outer corona beyond 2.2 R(sub Sun) in images from the SOHO/LASCO/C2 coronagraph. For these high-reaching jets, we find: (1) the front of the jet transits the corona below 2.2 R(sub Sun) at a speed typically several times the sound speed; (2) each jet displays an exceptionally large amount of spin as it erupts; (3) in the outer corona, most jets display oscillatory swaying having an amplitude of a few degrees and a period of order 1 hour. We conclude that these jets are magnetically driven, propose that the driver is a magnetic-untwisting wave that is grossly a large-amplitude (i.e., nonlinear) torsional Alfven wave that is put into the reconnected open magnetic field in the jet by interchange reconnection as the jet erupts, and estimate from the measured spinning and swaying that the magnetic-untwisting wave loses most of its energy in the inner corona below 2.2 R(sub Sun). From these results for these big jets, we reason that the torsional magnetic waves observed in Type-II spicules should dissipate in the corona in the same way and could thereby power much of the coronal heating in coronal holes.

  4. Observations of Multiple Blobs in Homologous Solar Coronal Jets in Closed Loop

    NASA Astrophysics Data System (ADS)

    Zhang, Q. M.; Ji, H. S.; Su, Y. N.

    2016-03-01

    Coronal bright points (CBPs) and jets are ubiquitous small-scale brightenings that are often associated with each other. We here report our multiwavelength observations of two groups of homologous jets. The first group was observed by the Extreme-Ultraviolet Imager (EUVI) onboard the Solar TErrestrial RElations Observatory (STEREO) Behind spacecraft in 171 Å and 304 Å on 2014 September 10, from a location where no data from the Solar Dynamic Observatory (SDO) could be obtained. The jets (J1 - J6) recurred for six times with intervals of 5 - 15 minutes. They originated from the same primary CBP (BP1) and propagated in the northeast direction along large-scale, closed coronal loops. Two of the jets (J3 and J6) produced sympathetic CBPs (BP2 and BP3) after reaching the remote footpoints of the loops. The time delays between the peak times of BP1 and BP2 (BP3) are 240±75 s (300±75 s). The jets were not coherent. Instead, they were composed of bright and compact blobs. The sizes and apparent velocities of the blobs are 4.5 - 9 Mm and 140 - 380 km s-1. The arrival times of the multiple blobs in the jets at the far end of the loops indicate that the sympathetic CBPs are caused by jet flows and not by thermal conduction fronts. The second group was observed by the Atmospheric Imaging Assembly onboard SDO in various wavelengths on 2010 August 3. Similar to the first group, the jets originated from a short-lived BP at the boundary of Active Region 11092 and propagated along a small-scale, closed loop before flowing into the active region. Several tiny blobs with sizes of ˜1.7 Mm and an apparent velocity of ˜238 km s^{-1} were identified in the jets. We carried out differential emission measure (DEM) inversions to investigate the temperatures of the blobs, finding that the blobs were multithermal with an average temperature of 1.8 - 3.1 MK. The estimated number densities of the blobs were (1.7 - 2.8)×109 cm^{-3}.

  5. OPENING ANGLES OF COLLAPSAR JETS

    SciTech Connect

    Mizuta, Akira; Ioka, Kunihito

    2013-11-10

    We investigate the jet propagation and breakout from the stellar progenitor for gamma-ray burst (GRB) collapsars by performing two-dimensional relativistic hydrodynamic simulations and analytical modeling. We find that the jet opening angle is given by θ{sub j} ∼ 1/5Γ{sub 0} and infer the initial Lorentz factor of the jet at the central engine, Γ{sub 0}, is a few for existing observations of θ{sub j}. The jet keeps the Lorentz factor low inside the star by converging cylindrically via collimation shocks under the cocoon pressure and accelerates at jet breakout before the free expansion to a hollow-cone structure. In this new picture, the GRB duration is determined by the sound crossing time of the cocoon, after which the opening angle widens, reducing the apparent luminosity. Some bursts violating the maximum opening angle θ{sub j,{sub max}} ∼ 1/5 ∼ 12° imply the existence of a baryon-rich sheath or a long-acting jet. We can explain the slopes in both Amati and Yonetoku spectral relations using an off-centered photosphere model, if we make only one assumption that the total jet luminosity is proportional to the initial Lorentz factor of the jet. We also numerically calibrate the pre-breakout model (Bromberg et al.) for later use.

  6. Magnetic Field Topology in Jets

    NASA Technical Reports Server (NTRS)

    Gardiner, T. A.; Frank, A.

    2000-01-01

    We present results on the magnetic field topology in a pulsed radiative. jet. For initially helical magnetic fields and periodic velocity variations, we find that the magnetic field alternates along the, length of the jet from toroidally dominated in the knots to possibly poloidally dominated in the intervening regions.

  7. Latest results from jet measurements

    NASA Astrophysics Data System (ADS)

    Bruna, Elena

    2009-10-01

    A first stage in understanding the phenomenon of jet quenching in the hot and dense nuclear matter has been successfully reached at RHIC through measurements of inclusive hadron suppression and di-hadron azimuthal correlations. A significant step forward in this field is being obtained by full jet reconstruction in heavy-ion collisions, that in principle should give access to the energy of the hard scattering independent of the presence of the medium and should enable the study of jet quenching at the partonic level. Due to the intrinsic difficulties of such a measurement in the high multiplicity environment, this is an innovative analysis and the first results of full jet reconstruction were obtained only over the last year thanks to the recently developed jet-finding techniques. We discuss the current methods to treat the large background, which is the main critical aspect that makes full jet reconstruction a challenge at RHIC. New measurements directed to address the mechanisms of partonic energy loss in hot QCD matter are presented. These measurements include the ratio of inclusive jet cross sections in Au+Au and p+p and the comparison of jet fragmentation functions in Au+Au and p+p.

  8. Jet charge at the LHC.

    PubMed

    Krohn, David; Schwartz, Matthew D; Lin, Tongyan; Waalewijn, Wouter J

    2013-05-24

    Knowing the charge of the parton initiating a light-quark jet could be extremely useful both for testing aspects of the standard model and for characterizing potential beyond-the-standard-model signals. We show that despite the complications of hadronization and out-of-jet radiation such as pileup, a weighted sum of the charges of a jet's constituents can be used at the LHC to distinguish among jets with different charges. Potential applications include measuring electroweak quantum numbers of hadronically decaying resonances or supersymmetric particles, as well as standard model tests, such as jet charge in dijet events or in hadronically decaying W bosons in tt[over ¯] events. We develop a systematically improvable method to calculate moments of these charge distributions by combining multihadron fragmentation functions with perturbative jet functions and pertubative evolution equations. We show that the dependence on energy and jet size for the average and width of the jet charge can be calculated despite the large experimental uncertainty on fragmentation functions. These calculations can provide a validation tool for data independent of Monte Carlo fragmentation models.

  9. Nonlinear Dynamics in Viscoelastic Jets

    NASA Astrophysics Data System (ADS)

    Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

    2008-11-01

    Instabilities in free surface continuous jets of non-Newtonian fluids, although relevant for many industrial processes, remain poorly understood in terms of fundamental fluid dynamics. Inviscid, and viscous Newtonian jets have been studied in considerable detail, both theoretically and experimentally. Instability in viscous jets leads to regular periodic coiling of the jet, which exhibits a non-trivial frequency dependence with the height of the fall. Here we present a systematic study of the effect of viscoelasticity on the dynamics of continuous jets of worm-like micellar surfactant solutions of varying viscosities and elasticities. We observe complex nonlinear spatio-temporal dynamics of the jet, and uncover a transition from periodic to quasi-periodic to a multi-frequency, broad-spectrum dynamics. Beyond this regime, the jet dynamics smoothly crosses over to exhibit the ``leaping shampoo'' or the Kaye effect. We examine different dynamical regimes in terms of scaling variables, which depend on the geometry (dimensionless height), kinematics (dimensionless flow rate), and the fluid properties (elasto-gravity number) and present a regime map of the dynamics of the jet in terms of these dimensionless variables.

  10. Nonlinear Dynamics in Viscoelastic Jets

    NASA Astrophysics Data System (ADS)

    Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

    2009-03-01

    Instabilities in free surface continuous jets of non-Newtonian fluids, although relevant for many industrial processes, remain poorly understood in terms of fundamental fluid dynamics. Inviscid, and viscous Newtonian jets have been studied in considerable detail, both theoretically and experimentally. Instability in viscous jets leads to regular periodic coiling of the jet, which exhibits a non-trivial frequency dependence with the height of the fall. Here we present a systematic study of the effect of viscoelasticity on the dynamics of continuous jets of worm-like micellar surfactant solutions of varying viscosities and elasticities. We observe complex nonlinear spatio-temporal dynamics of the jet, and uncover a transition from periodic to quasi-periodic to a multi-frequency, broad-spectrum dynamics. Beyond this regime, the jet dynamics smoothly crosses over to exhibit the ``leaping shampoo'' or the Kaye effect. We examine different dynamical regimes in terms of scaling variables, which depend on the geometry (dimensionless height), kinematics (dimensionless flow rate), and the fluid properties (elasto-gravity number) and present a regime map of the dynamics of the jet in terms of these dimensionless variables.

  11. Hydrodynamic Stability Analysis of Multi-jet Effects in Swirling Jet Combustors

    NASA Astrophysics Data System (ADS)

    Emerson, Benjamin; Lieuwen, Tim

    2016-11-01

    Many practical combustion devices use multiple swirling jets to stabilize flames. However, much of the understanding of swirling jet dynamics has been generated from experimental and computational studies of single reacting, swirling jets. A smaller body of literature has begun to explore the effects of multi-jet systems and the role of jet-jet interactions on the macro-system dynamics. This work uses local temporal and spatio-temporal stability analyses to isolate the hydrodynamic interactions of multiple reacting, swirling jets, characterized by jet diameter, D, and spacing, L. The results first identify the familiar helical modes in the single jet. Comparison to the multi-jet configuration reveals these same familiar modes simultaneously oscillating in each of the jets. Jet-jet interaction is mostly limited to a spatial synchronization of each jet's oscillations at the jet spacing values analyzed here (L/D =3.5). The presence of multiple jets vs a single jet has little influence on the temporal and absolute growth rates. The biggest difference between the single and multi-jet configurations is the presence of nearly degenerate pairs of hydrodynamic modes in the multi-jet case, with one mode dominated by oscillations in the inner jet, and the other in the outer jets. The close similarity between the single and multi-jet hydrodynamics lends insight into experiments from our group.

  12. Consolidating NASA's Arc Jets

    NASA Technical Reports Server (NTRS)

    Balboni, John A.; Gokcen, Tahir; Hui, Frank C. L.; Graube, Peter; Morrissey, Patricia; Lewis, Ronald

    2015-01-01

    The paper describes the consolidation of NASA's high powered arc-jet testing at a single location. The existing plasma arc-jet wind tunnels located at the Johnson Space Center were relocated to Ames Research Center while maintaining NASA's technical capability to ground-test thermal protection system materials under simulated atmospheric entry convective heating. The testing conditions at JSC were reproduced and successfully demonstrated at ARC through close collaboration between the two centers. New equipment was installed at Ames to provide test gases of pure nitrogen mixed with pure oxygen, and for future nitrogen-carbon dioxide mixtures. A new control system was custom designed, installed and tested. Tests demonstrated the capability of the 10 MW constricted-segmented arc heater at Ames meets the requirements of the major customer, NASA's Orion program. Solutions from an advanced computational fluid dynamics code were used to aid in characterizing the properties of the plasma stream and the surface environment on the calorimeters in the supersonic flow stream produced by the arc heater.

  13. Characterizing glottal jet turbulence.

    PubMed

    Alipour, Fariborz; Scherer, Ronald C

    2006-02-01

    Air pressure associated with airflow from the lungs drives the vocal folds into oscillation and allows the air to exit the glottis as a turbulent jet, even though laminar flow may enter the glottis from the trachea. The separation of the turbulence from the deterministic portion of the glottal jet was investigated in the excised canine larynx model. The present study is methodological in that the main goal was to examine three methods of obtaining reasonable representations of both the deterministic signal and the residual turbulence portion: (a) smoothing, (b) wavelet denoising, and (c) ensemble averaging. Ensemble averaging resulted in a deterministic signal that disregarded gross cyclic alterations while exaggerating the turbulence intensity. Wavelet denoising can perform an excellent analysis and synthesis of the glottal velocity, but was problematic in determining which levels of analysis to choose to represent both the deterministic and turbulence appropriately. Smoothing appeared to be the most appropriate for phonation velocities because it preserved gross cyclic variations important to perturbations and modulations, while extracting turbulence at what appears to be reasonable levels.

  14. [MK-801 or DNQX reduces electroconvulsive shock-induced impairment of learning-memory and hyperphosphorylation of Tau in rats].

    PubMed

    Liu, Chao; Min, Su; Wei, Ke; Liu, Dong; Dong, Jun; Luo, Jie; Liu, Xiao-Bin

    2012-08-25

    This study explored the effect of the excitatory amino acid receptor antagonists on the impairment of learning-memory and the hyperphosphorylation of Tau protein induced by electroconvulsive shock (ECT) in depressed rats, in order to provide experimental evidence for the study on neuropsychological mechanisms improving learning and memory impairment and the clinical intervention treatment. The analysis of variance of factorial design set up two intervention factors which were the electroconvulsive shock (two level: no disposition; a course of ECT) and the excitatory amino acid receptor antagonists (three level: iv saline; iv NMDA receptor antagonist MK-801; iv AMPA receptor antagonist DNQX). Forty-eight adult Wistar-Kyoto (WKY) rats (an animal model for depressive behavior) were randomly divided into six experimental groups (n = 8 in each group): saline (iv 2 mL saline through the tail veins of WKY rats ); MK-801 (iv 2 mL 5 mg/kg MK-801 through the tail veins of WKY rats) ; DNQX (iv 2 mL 5 mg/kg DNQX through the tail veins of WKY rats ); saline + ECT (iv 2 mL saline through the tail veins of WKY rats and giving a course of ECT); MK-801 + ECT (iv 2 mL 5 mg/kg MK-801 through the tail veins of WKY rats and giving a course of ECT); DNQX + ECT (iv 2 mL 5 mg/kg DNQX through the tail veins of WKY rats and giving a course of ECT). The Morris water maze test started within 1 day after the finish of the course of ECT to evaluate learning and memory. The hippocampus was removed from rats within 1 day after the finish of Morris water maze test. The content of glutamate in the hippocampus of rats was detected by high performance liquid chromatography. The contents of Tau protein which included Tau5 (total Tau protein), p-PHF1(Ser396/404), p-AT8(Ser199/202) and p-12E8(Ser262) in the hippocampus of rats were detected by immunohistochemistry staining (SP) and Western blot. The results showed that ECT and the glutamate ionic receptor blockers (NMDA receptor antagonist MK-801 and

  15. Electromagnetic jets from compact objects

    NASA Technical Reports Server (NTRS)

    Michel, F. Curtis

    1987-01-01

    The possibility that at least some astrophysical jets are initially electromagnetic in origin is examined. Subsequent pick-up of ionization would convert such electromagnetic jets into hydrodynamic jets. In such a model, relativistic outflow is formed into highly collimated beams simply through the interaction with the surrounding medium. Forming jets under such general circumstances is encouraging in view of the range of scales that appear to be involved. The overall properties of such jets are largely determined by a single dimensionless parameter: the characteristic electrostatic potential drop rewritten as a particle Lorentz factor. Consequently, the determination of any one observable, such as the total power output, also determines the particle energy scale, the electromagnetic field strengths, etc.

  16. Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth.

    PubMed

    Lai, Wei-Ting; Cheng, Kai-Lin; Baruchello, Riccardo; Rondanin, Riccardo; Marchetti, Paolo; Simoni, Daniele; Lee, Ray M; Guh, Jih-Hwa; Hsu, Lih-Ching

    2016-08-01

    We reported previously that a hemiasterlin derivative BF65 is a potent anticancer agent that can inhibit microtubule assembly. Here we show that a more potent stereospecific diastereomer (R)(S)(S)-BF65 can synergize with an allosteric Akt inhibitor MK-2206 to suppress the growth of SKOV3 ovarian cancer cells with constitutively active Akt. (R)(S)(S)-BF65 induced mitotic arrest and MK-2206 caused G0/G1 arrest, while the combination of both induced simultaneous G0/G1 and G2/M cell cycle arrest. (R)(S)(S)-BF65 induced phosphorylation and inactivation of Bcl-2, and downregulated Mcl-1, consequently may lead to apoptosis. (R)(S)(S)-BF65 inhibited mitogen-activated protein kinases (MAPKs), which may stimulate cell proliferation upon activation. (R)(S)(S)-BF65 also induced DNA damage after long-term treatment. MK-2206 is known to inhibit phosphorylation and activation of Akt and suppress cancer cell growth. The combination of (R)(S)(S)-BF65 and MK-2206 also inhibited the Akt pathway. Interestingly, MK-2206 upregulated Bcl-2 and induced activation of MAPKs in SKOV3 cells; however, when combined with (R)(S)(S)-BF65, these prosurvival effects were reversed. The combination also more significantly decreased Mcl-1 protein, increased PARP cleavage, and induced γ-H2AX, a DNA damage marker. Remarkably, MK-2206 enhanced the microtubule depolymerization effect of (R)(S)(S)-BF65. The combination of (R)(S)(S)-BF65 and MK-2206 also markedly inhibited cell migration. Thus, MK-2206 synergizes with (R)(S)(S)-BF65 to inhibit SKOV3 cell growth via downregulating the Akt signaling pathway, and enhancing the microtubule disruption effect of (R)(S)(S)-BF65. (R)(S)(S)-BF65 in turn suppresses Bcl-2 and MAPKs induced by MK-2206. (R)(S)(S)-BF65 and MK-2206 compensate each other leading to increased apoptosis and enhanced cytotoxicity, and may also suppress cancer cell invasion.

  17. Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge.

    PubMed

    Hughes, P E; Young, D; Preston, K M; Yan, Q; Dragunow, M

    1998-01-01

    Transient changes in immediate-early genes and neurotrophin expression produced by kindling stimulation may mediate secondary downstream events involved in kindling development. Recent experiments have demonstrated conclusively that both kindling progression and mossy fibre sprouting are significantly impaired by administration of the N-methyl-D-aspartate (NMDA) receptor antagonist MK801. To further examine the link between kindling, changes in gene expression and the NMDA receptor, we examined the effects of MK801 on neuronal induction of immediate-early genes, brain-derived neurotrophic factor (BDNF) and trk receptor mRNA expression produced by a single electrically induced hippocampal after-discharge in rats. The after-discharge produced a rapid (after 1 h) increase in Fos, Jun-B, c-Jun, Krox-24 mRNA and protein and Krox-20 protein in dentate granule neurons and a delayed, selective expression of Fos, Jun-D and Krox-24 in hilar interneurons. MK801 pretreatment produced a very strong inhibition of Fos, Jun-D and Krox-20 increases in dentate neurons but had a much smaller effect on Jun-B and c-Jun expression. MK801 did not inhibit Krox-24 expression in granule neurons or the delayed expression of Fos, Jun-D and Krox-24 in hilar interneurons. BDNF protein and trk B and trk C mRNA expression were also strongly induced in dentate granule cells 4 h following an after-discharge. MK801 abolished the increase in BDNF protein and trk B, but not trk C mRNA in granule cells at 4 h. These results demonstrate that MK801 differentially regulates the AD-increased expression of a group of genes previously identified as being likely candidates for an involvement in kindling. Because MK801 significantly retards the development of kindling and mossy fibre sprouting, it can be argued that those genes whose induction is not significantly attenuated by MK801 are unlikely to play an important role in the MK801-sensitive component of kindling and the changes in neural connectivity

  18. Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms.

    PubMed

    Hiyoshi, T; Kambe, D; Karasawa, J; Chaki, S

    2014-11-07

    Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in schizophrenia. Aberrations in GBO power have attracted attention as a translational biomarker for the development of novel antipsychotic drugs. However, the neuronal mechanisms as well as the pharmacological significance of NMDAr antagonist-induced aberrant GBO power have not been fully investigated. In the present study, to address the above questions, we examined the pharmacological properties of MK-801 (0.1 mg/kg)-increased basal GBO power in rat cortical EEG. Riluzole (3-10 mg/kg), a glutamate release inhibitor, reduced the MK-801-increased basal GBO power. In contrast, L-838,417 (1-3 mg/kg), an α2/3/5 subunit-selective GABAA receptor-positive allosteric modulator, enhanced the GBO increase. Antipsychotics such as haloperidol (0.05-0.3 mg/kg) and clozapine (1-10 mg/kg) dose-dependently attenuated the MK-801-increased GBO power. Likewise, LY379268 (0.3-3 mg/kg), an metabotropic glutamate 2/3 receptor (mGlu2/3 receptor) agonist, reduced the GBO increase in a dose-dependent manner, which was antagonized by an mGlu2/3 receptor antagonist LY341495. These results suggest that an increase in cortical GBO power induced by NMDAr hypofunction can be attributed to the aberrant activities of both excitatory pyramidal neurons and inhibitory interneurons in local circuits. The aberrant cortical GBO power reflecting cortical network dysfunction observed in schizophrenia might be a useful biomarker for the discovery of novel antipsychotic drugs.

  19. Mammalian cell killing by ultrasoft X rays and high-energy radiation: an extension of the MK model.

    PubMed

    Hawkins, Roland B

    2006-08-01

    An alternate formulation of the microdosimetric-kinetic (MK) model is presented that applies to irradiation of mammalian cells with ultrasoft X rays as well as high-energy radiations of variable linear energy transfer (LET). Survival and DNA double-strand break measurements for V79 cells from the literature are examined to illustrate application of the model. It is demonstrated that the linear component of the linear-quadratic survival relationship (alpha) is enhanced because repairable potentially lethal lesions formed from a single ultrasoft X-ray energy deposition event, when closer on average than for a single high-energy radiation event, are more likely to combine to form a lethal lesion. The quadratic component (beta) of the linear-quadratic survival relationship is increased because the potentially lethal lesions formed by ultrasoft X rays are created with greater efficiency than those of high-energy radiation. In addition, potentially lethal lesions from very low-energy carbon K-shell X rays may be enriched in structural forms that favor combination to form lethal lesions instead of repair. These features account for the increased effectiveness of killing of V79 cells by ultrasoft X rays compared to cobalt-60 gamma radiation. The importance of pairwise combination of potentially lethal lesions to form exchange chromosome aberrations that become lethal lesions is discussed. The extended MK model explains and reconciles differences between the MK model and the theory of dual radiation action on the one hand, and on the other, the view that variation in the RBE with radiation quality is explained by differences in energy deposition in nanometer- rather than micrometer-size volumes.

  20. Unmanned Evaluation of the U.S. Navy MK 15 Closed-Circuit UBA (underwater Breathing Apparatus).

    DTIC Science & Technology

    1983-07-01

    FUNCTIONAL DESCRIPTION (Figure 5) The MK 15 is a closed circuit rebreather capable of providing approximately 595 liters (21 cu. ft.) of both 02 and a...8217Evaluation of Modified DRAEGER LAR V Closed - Circuit Oxygen Rebreather ,’ James R. Middleton and Claude A. Piantadosi, August i979. 4. NEDU Report 2-80...8217 Unmanned Evaluation of U.S. Navy UBA EX-16 Pre-production Model Closed Circuit Rebreather ,’ James R. Middleton, December 1979. 13 -p.ItI)1& A%0

  1. Computational Modeling And Analysis Of Synthetic Jets

    NASA Technical Reports Server (NTRS)

    Mittal, Rajat; Cattafesta, Lou

    2005-01-01

    In the last report we focused on the study of 3D synthetic jets of moderate jet aspect-ratio. Jets in quiescent and cross-flow cases were investigated. Since most of the synthetic jets in practical applications are found to be of large aspect ratio, the focus was shifted to studying synthetic jets of large aspect ratio. In the current year, further progress has been made by studying jets of aspect ratio 8 and infinity. Some other aspects of the jet, like the vorticity flux is looked into apart from analyzing the vortex dynamics, velocity profiles and the other dynamical characteristics of the jet which allows us to extract some insight into the effect of these modifications on the jet performance. Also, efforts were made to qualitatively validate the simulated results with the NASA Langley test cases at higher jet Reynolds number for the quiescent jet case.

  2. The structure of jet turbulence producing jet noise.

    NASA Technical Reports Server (NTRS)

    Wooldridge, C. E.; Wooten, D. C.; Amaro, A. J.

    1972-01-01

    Measurements are presented that characterize the structure of the jet in both the core and the surrounding annular mixing region. Experiments were carried out in a 1.5-inch diameter subsonic jet at Mach numbers of 0.3, 0.5, and 0.7. The growth of pressure fluctuations within the core from the jet outlet to the end of the jet core was traced through the examination of spectral results. The spectra in the jet core exhibited a peak whose frequency scaled with the jet velocity and the jet diameter which is related to a characteristic dimension of the mixing process. A digital data reduction program was used to calculate the auto- and cross-correlations of axial velocity fluctuations. In the core the cross-correlations were nearly constant in the space-time plane indicating a traveling pressure wave, while in the annular mixing region the cross-correlations exhibited the usual decay in the space-time plane characteristic of convected turbulence.

  3. Effect of 3-bromopyruvate and atovaquone on infection during in vitro interaction of Toxoplasma gondii and LLC-MK2 cells.

    PubMed

    de Lima, Loyze Paola O; Seabra, Sergio H; Carneiro, Henrique; Barbosa, Helene S

    2015-09-01

    Toxoplasma gondii infection can be severe during pregnancy and in immunocompromised patients. Current therapies for toxoplasmosis are restricted to tachyzoites and have little or no effect on bradyzoites, which are maintained in tissue cysts. Consequently, new therapeutic alternatives have been proposed as the use of atovaquone has demonstrated partial efficacy against tachyzoites and bradyzoites. This work studies the effect of 3-bromopyruvate (3-BrPA), a compound that is being tested against cancer cells, on the infection of LLC-MK2 cells with T. gondii tachyzoites, RH strain. No effect of 3-BrPA on host cell proliferation or viability was observed, but it inhibited the proliferation of T. gondii. The incubation of cultures with lectin Dolichos biflorus agglutinin (DBA) showed the development of cystogenesis, and an ultrastructural analysis of parasite intracellular development confirmed morphological characteristics commonly found in tissue cysts. Moreover, the presence of degraded parasites and the influence of 3-BrPA on endodyogeny were observed. Infected cultures were alternatively treated with a combination of this compound plus atovaquone. This resulted in a 73% reduction in intracellular parasites after 24 h of treatment and a 71% reduction after 48 h; cyst wall formation did not occur in these cultures. Therefore, we conclude that the use of 3-BrPA may serve as an important tool for the study of (i) in vitro cystogenesis; (ii) parasite metabolism, requiring a deeper understanding of the target of action of this compound on T. gondii; (iii) the alternative parasite metabolic pathways; and (iv) the molecular/cellular mechanisms that trigger parasite death.

  4. Effect of 3-Bromopyruvate and Atovaquone on Infection during In Vitro Interaction of Toxoplasma gondii and LLC-MK2 Cells

    PubMed Central

    de Lima, Loyze Paola O.; Seabra, Sergio H.; Carneiro, Henrique

    2015-01-01

    Toxoplasma gondii infection can be severe during pregnancy and in immunocompromised patients. Current therapies for toxoplasmosis are restricted to tachyzoites and have little or no effect on bradyzoites, which are maintained in tissue cysts. Consequently, new therapeutic alternatives have been proposed as the use of atovaquone has demonstrated partial efficacy against tachyzoites and bradyzoites. This work studies the effect of 3-bromopyruvate (3-BrPA), a compound that is being tested against cancer cells, on the infection of LLC-MK2 cells with T. gondii tachyzoites, RH strain. No effect of 3-BrPA on host cell proliferation or viability was observed, but it inhibited the proliferation of T. gondii. The incubation of cultures with lectin Dolichos biflorus agglutinin (DBA) showed the development of cystogenesis, and an ultrastructural analysis of parasite intracellular development confirmed morphological characteristics commonly found in tissue cysts. Moreover, the presence of degraded parasites and the influence of 3-BrPA on endodyogeny were observed. Infected cultures were alternatively treated with a combination of this compound plus atovaquone. This resulted in a 73% reduction in intracellular parasites after 24 h of treatment and a 71% reduction after 48 h; cyst wall formation did not occur in these cultures. Therefore, we conclude that the use of 3-BrPA may serve as an important tool for the study of (i) in vitro cystogenesis; (ii) parasite metabolism, requiring a deeper understanding of the target of action of this compound on T. gondii; (iii) the alternative parasite metabolic pathways; and (iv) the molecular/cellular mechanisms that trigger parasite death. PMID:26077255

  5. Tracing Carina's protostellar jets to the source with WFC3-IR

    NASA Astrophysics Data System (ADS)

    Smith, Nathan

    2010-09-01

    Based on a recent H-alpha imaging survey of the Carina Nebula with ACS, we discovered 39 new Herbig-Haro {HH} jets marking the bipolar outflows from newly formed low-mass stars. This provides a valuable sample of jets that are all at the same distance, allowing us to study the relationship between protostars and their outflows where nearby massive stars are shredding the molecular cloud as new stars are forming. Carina has been studied extensively with Spitzer and Chandra, providing IR spectral energy distributions and X-ray luminosities for all detectable sources in the field. However, 29 of the jets seen at visual wavelengths emerge from opaque clouds or dark globules seen in silhouette against the bright background H II region, so the protostellar driving sources are still embedded in their natal clouds and are not identifiable in optical images. This makes the identification of the driving sources in lower resolution Spitzer and Chandra images ambiguous. Three of these jets {HH666, HH901, and HH902} have already been imaged with WFC3 as ERO targets after the servicing mission, demonstrating that near-IR [Fe II] emission lines in the F126N and F164N filters provide an excellent way to trace the jet emission back into the cloud and to thereby identify which embedded star is driving the outflow. Here we propose to obtain WFC3-IR images of [Fe II] emission from the remaining embedded jets in order to link the jets to the protostars that launch them. This will then permit a comparison of the jet properties to protostar properties for the full sample. Additionally, the flux ratio of these two [Fe II] lines will probe the spatially dependent extinction through the cloud all the way back to the source, providing a map of the density structure in the protostar's extended circumstellar envelope.

  6. Deflection of jets induced by jet-cloud and jet-galaxy interactions

    NASA Astrophysics Data System (ADS)

    Mendoza, S.; Longair, M. S.

    2001-06-01

    The model first introduced by Raga & Cantó in which astrophysical jets are deflected on passing through an isothermal high-density region is generalized by taking into account gravitational effects on the motion of the jet as it crosses the high-density cloud. The problem is also generalized for relativistic jets in which gravitational effects induced by the cloud are neglected. Two further cases, classical and relativistic, are discussed for the cases in which the jet is deflected on passing through the interstellar gas of a galaxy in which a dark matter halo dominates the gravitational potential. The criteria for the stability of jets due to the formation of internal shocks are also discussed.

  7. Overview of JET results

    NASA Astrophysics Data System (ADS)

    Paméla, J.; Solano, Emilia R.; EFDA Contributors, JET

    2003-12-01

    Scientific and technical activities on JET focus on the issues likely to affect the ITER design and operation. Our understanding of the ITER reference mode of operation, the ELMy H-mode, has progressed significantly. The extrapolation of ELM size to ITER has been re-evaluated. Neoclassical tearing modes have been shown to be meta-stable in JET, and their beta limits can be raised by destabilization (modification) of sawteeth by ion cyclotron radio frequency heating (ICRH). Alpha simulation experiments with ICRH accelerated injected 4He beam ions provide a new tool for fast particle and magnetohydrodynamic studies, with up to 80-90% of plasma heating by fast 4He ions. With or without impurity seeding, a quasi-steady-state high confinement (H98 = 1), high density (ne/nGW = 0.9-1) and high bgr (bgrN = 2) ELMy H-mode has been achieved by operating near the ITER triangularity (dgr~ 0.40-0.5) and safety factor (q95~ 3), at Zeff~ 1.5-2. In advanced tokamak (AT) scenarios, internal transport barriers (ITBs) are now characterized in real time with a new criterion, \\rho^*_T . Tailoring of the current profile with lower hybrid current drive provides reliable access to a variety of q profiles, lowering access power for barrier formation. Rational q surfaces appear to be associated with ITB formation. Alfvén cascades were observed in reversed shear plasmas, providing identification of q profile evolution. Plasmas with 'current holes' were observed and modelled. Transient high confinement AT regimes with H89 = 3.3, bgrN = 2.4 and ITER-relevant q < 5 were achieved with reversed magnetic shear. Quasi-stationary ITBs are developed with full non-inductive current drive, including ~50% bootstrap current. A record duration of ITBs was achieved, up to 11 s, approaching the resistive time. For the first time, pressure and current profiles of AT regimes are controlled by a real-time feedback system, in separate experiments. Erosion and co-deposition studies with a quartz micro

  8. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats.

    PubMed

    Singh, Sonu; Mishra, Akanksha; Srivastava, Neha; Shukla, Shubha

    2017-03-15

    Adult hippocampal neurogenesis is directly involved in regulation of stress, anxiety, and depression that are commonly observed nonmotor symptoms in Parkinson's disease (PD). These symptoms do not respond to pharmacological dopamine replacement therapy. Excitotoxic damage to neuronal cells by N-methyl-d-aspartate (NMDA) receptor activation is also a major contributing factor in PD development, but whether it regulates hippocampal neurogenesis and nonmotor symptoms in PD is yet unexplored. Herein, for the first time, we studied the effect of MK-801, an NMDA receptor antagonist, on adult hippocampal neurogenesis and behavioral functions in 6-OHDA (6-hydroxydopamine) induced rat model of PD. MK-801 treatment (0.2 mg/kg, ip) increased neural stem cell (NSC) proliferation, self-renewal capacity, long-term survival, and neuronal differentiation in the hippocampus of rat model of PD. MK-801 potentially enhanced long-term survival, improved dendritic arborization of immature neurons, and reduced 6-OHDA induced neurodegeneration via maintaining the NSC pool in hippocampus, leading to decreased anxiety and depression-like phenotypes in the PD model. MK-801 inhibited glycogen synthase kinase-3β (GSK-3β) through up-regulation of Wnt-3a, which resulted in the activation of Wnt/β-catenin signaling leading to enhanced hippocampal neurogenesis in PD model. Additionally, MK-801 treatment protected the dopaminergic (DAergic) neurons in the nigrostriatal pathway and improved motor functions by increasing the expression of Nurr-1 and Pitx-3 in the PD model. Therefore, MK-801 treatment serves as a valuable tool to enhance hippocampal neurogenesis in PD, but further studies are needed to revisit the role of MK-801 in the neurodegenerative disorder before proposing a potential therapeutic candidate.

  9. Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen.

    PubMed

    Arai, Sawako; Takuma, Kazuhiro; Mizoguchi, Hiroyuki; Ibi, Daisuke; Nagai, Taku; Takahashi, Kenji; Kamei, Hiroyuki; Nabeshima, Toshitaka; Yamada, Kiyofumi

    2008-12-01

    We have previously demonstrated that pallidotegmental GABAergic neurons play a crucial role in prepulse inhibition (PPI) of the startle reflex in mice through the activation of GABA(B) receptors in pedunculopontine tegmental neurons. In this study, we investigated whether PPI disruption induced by methamphetamine (METH) or MK-801 is associated with the dysfunction of pallidotegmental neurons. Furthermore, we examined the effects of baclofen, a GABA(B) receptor agonist, on METH- and MK-801-induced PPI impairment. Acute treatment with METH (3 mg/kg, subcutaneouly (s.c.)) and MK-801 (>0.3 mg/kg, s.c.) significantly disrupted PPI, accompanied by the suppression of c-Fos expression in lateral globus pallidus induced by PPI. Furthermore, acute treatment with METH and MK-801 stimulated c-Fos expression in the caudal pontine reticular nucleus (PnC) in mice subjected to the PPT test, although PPI alone had no effect on c-Fos expression. Repeated treatment with 1 mg/kg METH for 7 days, which did not affect PPI acutely, showed similar effects on PPI and c-Fos expression to acute treatment with METH (3 mg/kg). Baclofen dose-dependently ameliorated PPI impairment induced by acute treatment with METH (3 mg/kg) and MK-801 (1 mg/kg), and decreased METH- and MK-801-stimulated c-Fos expression in PnC to the basal level. These results suggest that dysfunction of pallidotegmental neurons is involved in PPI disruption caused by METH and MK-801 in mice. GABA(B) receptor may constitute a putative target in treating neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia and METH psychosis.

  10. Colletotrichum higginsianum Mitogen-Activated Protein Kinase ChMK1: Role in Growth, Cell Wall Integrity, Colony Melanization, and Pathogenicity

    PubMed Central

    Wei, Wei; Xiong, Ying; Zhu, Wenjun; Wang, Nancong; Yang, Guogen; Peng, Fang

    2016-01-01

    Colletotrichum higginsianum is an economically important pathogen that causes anthracnose disease in a wide range of cruciferous crops. To facilitate the efficient control of anthracnose disease, it will be important to understand the mechanism by which the cruciferous crops and C. higginsianum interact. A key step in understanding this interaction is characterizing the mitogen-activated protein kinases (MAPK) signaling pathway of C. higginsianum. MAPK plays important roles in diverse physiological processes of multiple pathogens. In this study, a Fus3/Kss1-related MAPK gene, ChMK1, from C. higginsianum was analyzed. The results showed that the Fus3/Kss1-related MAPK ChMK1 plays a significant role in cell wall integrity. Targeted deletion of ChMK1 resulted in a hypersensitivity to cell wall inhibitors, reduced conidiation and albinistic colonies. Further, the deletion mutant was also unable to form melanized appressorium, a specialized infection structure that is necessary for successful infection. Therefore, the deletion mutant loses pathogenicity on A. thaliana leaves, demonstrating that ChMK1 plays an essential role in the early infection step. In addition, the ChMK1 deletion mutant showed an attenuated growth rate that is different from that of its homolog in Colletotrichum lagenarium, indicating the diverse roles that Fus3/Kss1-related MAPKs plays in phytopathogenic fungi. Furthermore, the expression level of three melanin synthesis associated genes were clearly decreased in the albinistic ChMK1 mutant compared to that of the wild type strain, suggesting that ChMK1 is also required for colony melanization in C. higginsianum. PMID:27536296

  11. Measurement of the ratio of differential cross sections σ(pp̄→Z+b jet)/σ(pp̄→Z+jet) in pp̄ collisions at √s=1.96 TeV

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Brown, J.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chakraborty, D.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M.-C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duggan, D.; Duperrin, A.; Dutt, S.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Facini, G.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garcia-Bellido, A.; García-González, J. A.; García-Guerra, G. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J.-F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Kasper, P. A.; Katsanos, I.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Landsberg, G.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Maravin, Y.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Naimuddin, M.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Padilla, M.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M.-A.; Podesta-Lerma, P. L. M.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Rangel, M. S.; Ranjan, K.; Ratoff, P. N.; Razumov, I.; Renkel, P.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Salcido, P.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Shivpuri, R. K.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Smith, K. J.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y.-T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verdier, P.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; White, A.

    2013-05-28

    We measure the ratio of cross sections, σ(pp̄→Z+b jet)/σ(pp̄→Z+jet), for associated production of a Z boson with at least one jet. The ratio is also measured as a function of the Z boson transverse momentum, jet transverse momentum, jet pseudorapidity, and the azimuthal angle between the Z boson with respect to the highest pT b tagged jet. These measurements use data collected by the D0 experiment in Run II of Fermilab’s Tevatron pp̄ Collider at a center-of-mass energy of 1.96 TeV, and correspond to an integrated luminosity of 9.7 fb⁻¹. The results are compared to predictions from next-to-leading order calculations and various Monte Carlo event generators.

  12. Measurement of the ratio of differential cross sections σ(pp̄→Z+b jet)/σ(pp̄→Z+jet) in pp̄ collisions at √s=1.96 TeV

    DOE PAGES

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; ...

    2013-05-28

    We measure the ratio of cross sections, σ(pp̄→Z+b jet)/σ(pp̄→Z+jet), for associated production of a Z boson with at least one jet. The ratio is also measured as a function of the Z boson transverse momentum, jet transverse momentum, jet pseudorapidity, and the azimuthal angle between the Z boson with respect to the highest pT b tagged jet. These measurements use data collected by the D0 experiment in Run II of Fermilab’s Tevatron pp̄ Collider at a center-of-mass energy of 1.96 TeV, and correspond to an integrated luminosity of 9.7 fb⁻¹. The results are compared to predictions from next-to-leading order calculationsmore » and various Monte Carlo event generators.« less

  13. Measurements of jet and multijet cross sections with the CDF detector

    SciTech Connect

    Matthias Toennesmann

    2003-11-18

    Recent measurements of jet and multijet production cross sections from p{bar p} collisions recorded with the Collider Detector at Fermilab (CDF) are summarized. First Run II results of the inclusive one jet cross section at {radical}s = 1.96 TeV as well as prospects for future extensions of this measurement are presented. We also studied the properties of three-jet events in Run Ib data at {radical}s = 1.8 TeV. All results are compared to predictions of Quantum Chromodynamics at next-to-leading order perturbation theory.

  14. Measurement of the top quark mass in lepton+jets events with secondary vertex tagging

    SciTech Connect

    Harrington, Robert Duane

    2007-02-01

    A measurement of the top quark mass with the matrix element method in the lepton + jets final state in D0 Run II is presented. Events with single isolated energetic charged lepton (electron or muon), exactly four calorimeter jets, and significant missing transverse energy are selected. Probabilities used to discriminate between signal and background are assumed to be proportional to differential cross-sections, calculated using event kinematics and folding in object resolutions and parton distribution functions. The event likelihoods constructed using these probabilities are varied with the top quark mass, m{sub t}, and the jet energy scale, JES, to give the smallest possible combined statistical + JES uncertainty.

  15. Defensive spray of the bombardier beetle: a biological pulse jet.

    PubMed

    Dean, J; Aneshansley, D J; Edgerton, H E; Eisner, T

    1990-06-08

    The defensive spray of the bombardier beetle Stenaptinus insignis is ejected in quick pulses (at about 500 pulses per second) rather than as a continuous stream. The pulsation may be a consequence of intermittency in the explosive chemical process that generates the spray. The ejection system of the beetle shows basic similarity to the pulse jet propulsion mechanism of the German V-1 "buzz" bomb of World War II.

  16. Micromachined chemical jet dispenser

    DOEpatents

    Swierkowski, Steve P.

    1999-03-02

    A dispenser for chemical fluid samples that need to be precisely ejected in size, location, and time. The dispenser is a micro-electro-mechanical systems (MEMS) device fabricated in a bonded silicon wafer and a substrate, such as glass or silicon, using integrated circuit-like fabrication technology which is amenable to mass production. The dispensing is actuated by ultrasonic transducers that efficiently produce a pressure wave in capillaries that contain the chemicals. The 10-200 .mu.m diameter capillaries can be arranged to focus in one spot or may be arranged in a larger dense linear array (.about.200 capillaries). The dispenser is analogous to some ink jet print heads for computer printers but the fluid is not heated, thus not damaging certain samples. Major applications are in biological sample handling and in analytical chemical procedures such as environmental sample analysis, medical lab analysis, or molecular biology chemistry experiments.

  17. Micromachined chemical jet dispenser

    DOEpatents

    Swierkowski, S.P.

    1999-03-02

    A dispenser is disclosed for chemical fluid samples that need to be precisely ejected in size, location, and time. The dispenser is a micro-electro-mechanical systems (MEMS) device fabricated in a bonded silicon wafer and a substrate, such as glass or silicon, using integrated circuit-like fabrication technology which is amenable to mass production. The dispensing is actuated by ultrasonic transducers that efficiently produce a pressure wave in capillaries that contain the chemicals. The 10-200 {micro}m diameter capillaries can be arranged to focus in one spot or may be arranged in a larger dense linear array (ca. 200 capillaries). The dispenser is analogous to some ink jet print heads for computer printers but the fluid is not heated, thus not damaging certain samples. Major applications are in biological sample handling and in analytical chemical procedures such as environmental sample analysis, medical lab analysis, or molecular biology chemistry experiments. 4 figs.

  18. Water cooled steam jet

    DOEpatents

    Wagner, E.P. Jr.

    1999-01-12

    A water cooled steam jet for transferring fluid and preventing vapor lock, or vaporization of the fluid being transferred, has a venturi nozzle and a cooling jacket. The venturi nozzle produces a high velocity flow which creates a vacuum to draw fluid from a source of fluid. The venturi nozzle has a converging section connected to a source of steam, a diffuser section attached to an outlet and a throat portion disposed there between. The cooling jacket surrounds the venturi nozzle and a suction tube through which the fluid is being drawn into the venturi nozzle. Coolant flows through the cooling jacket. The cooling jacket dissipates heat generated by the venturi nozzle to prevent vapor lock. 2 figs.

  19. Water cooled steam jet

    DOEpatents

    Wagner, Jr., Edward P.

    1999-01-01

    A water cooled steam jet for transferring fluid and preventing vapor lock, or vaporization of the fluid being transferred, has a venturi nozzle and a cooling jacket. The venturi nozzle produces a high velocity flow which creates a vacuum to draw fluid from a source of fluid. The venturi nozzle has a converging section connected to a source of steam, a diffuser section attached to an outlet and a throat portion disposed therebetween. The cooling jacket surrounds the venturi nozzle and a suction tube through which the fluid is being drawn into the venturi nozzle. Coolant flows through the cooling jacket. The cooling jacket dissipates heat generated by the venturi nozzle to prevent vapor lock.

  20. Commercial jet transport crashworthiness

    NASA Technical Reports Server (NTRS)

    Widmayer, E.; Brende, O. B.

    1982-01-01

    The results of a study to identify areas of research and approaches that may result in improved occupant survivability and crashworthiness of transport aircraft are given. The study defines areas of structural crashworthiness for transport aircraft which might form the basis for a research program. A 10-year research and development program to improve the structural impact resistance of general aviation and commercial jet transport aircraft is planned. As part of this program parallel studies were conducted to review the accident experience of commercial transport aircraft, assess the accident performance of structural components and the status of impact resistance technology, and recommend areas of research and development for that 10-year plan. The results of that study are also given.

  1. Results on QCD Physics from the CDF-II Experiment

    SciTech Connect

    Pagliarone, C.; /Cassino U. /INFN, Pisa

    2006-12-01

    In this paper the authors review a selection of recent results obtained, in the area of QCD physics, from the CDF-II experiment that studies p{bar p} collisions at {radical}s = 1.96 TeV provided by the Fermilab Tevatron Collider. All results shown correspond to analysis performed using the Tevatron Run II data samples. In particular they will illustrate the progress achieved and the status of the studies on the following QCD processes: jet inclusive production, using different jet clustering algorithm, W({yields} e{nu}{sub e}) + jets and Z({yields} e{sup +}e{sup -}) + jets production, {gamma} + b-jet production, dijet production in double pomeron exchange and finally exclusive e{sup +}e{sup -} and {gamma}{gamma} production. No deviations from the Standard Model have been observed so far.

  2. Fibrillar Chromospheric Spicule-Like Counterparts to an EUV and Soft X-Ray Blowout Coronal Jet

    NASA Technical Reports Server (NTRS)

    Sterling, Alphonse C.; Harra, Louise K.; Moore, Ronald L.

    2010-01-01

    We observe an erupting jet feature in a solar polar coronal hole, using data from Hinode/SOT, EIS, and XRT, with supplemental data from STEREO/EUVI. From EUV and soft X-ray (SXR) images we identify the erupting feature as a blowout coronal jet: in SXRs it is a jet with bright base, and in EUV it appears as an eruption of relatively cool (approximately 50,000 K) material of horizontal size scale approximately 30" originating from the base of the SXR jet. In SOT Ca II H images the most pronounced analog is a pair of thin (approximately 1") ejections, at the locations of either of the two legs of the erupting EUV jet. These Ca II features eventually rise beyond 45", leaving the SOT field of view, and have an appearance similar to standard spicules except that they are much taller. They have velocities similar to that of "type II" spicules, approximately 100 kilometers per second, and they appear to have spicule-like substructures splitting off from them with horizontal velocity approximately 50 kilometers per second, similar to the velocities of splitting spicules measured by Sterling et al. (2010). Motions of splitting features and of other substructures suggest that the macroscopic EUV jet is spinning or unwinding as it is ejected. This and earlier work suggests that a sub-population of Ca II type II spicules are the Ca II manifestation of portions of larger-scale erupting magnetic jets. A different sub-population of type II spicules could be blowout jets occurring on a much smaller horizontal size scale than the event we observe here.

  3. FIBRILLAR CHROMOSPHERIC SPICULE-LIKE COUNTERPARTS TO AN EXTREME-ULTRAVIOLET AND SOFT X-RAY BLOWOUT CORONAL JET

    SciTech Connect

    Sterling, Alphonse C.; Moore,