Foreword: Sir John Pendry FRS Sir John Pendry FRS

NASA Astrophysics Data System (ADS)

Inglesfield, John; Echenique, Pedro

2008-07-01

John Pendry John Inglesfield and Pedro Echenique write: John Pendry's 65th birthday is on 4 July 2008, and this issue of the Journal of Physics: Condensed Matter is dedicated to him, with articles by friends, colleagues, and former students. By any standards, John Pendry is a great scientist, who has made—and continues to make—an enormous contribution to physics; the wide range of his interests is reflected in the scope of these articles. Not many scientists can establish a completely new and unexpected area of research, but this has been John's achievement in the last few years in the field of metamaterials, materials whose electromagnetic properties depend on their structure rather than the materials of which the structure is built. In this way, structures with effectively negative electrical permittivity and negative magnetic permeability can be constructed, demonstrating negative refraction; through metamaterials scientists now have access to properties not found in nature, and never previously explored experimentally. Never a week goes by without a potential new application of metamaterials, whether it is perfect lensing, or the cloak of invisibility. This has certainly led to tremendous visibility for John himself, with guest lectures all over the world, and radio and television appearances. John Pendry's first paper was published exactly 40 years ago, 'Analytic properties of pseudopotentials' [1], and since then he has published 310 articles at the latest count. But this first paper already reflected something of the way John works. His PhD project, with Volker Heine at the Cavendish Laboratory, was to interpret the scattering of low energy electrons from surfaces, the technique of LEED which was to become the method of choice for determining surface structure. Although the energy of the electrons in LEED is relatively low—say 50 eV—it is much higher than the energy of the conduction electrons, for which pseudopotentials had been devised, and John

St. John's Wort (image)

MedlinePlus

The herb St. John's Wort is believed to be helpful in relieving mild to moderate depression, but should only be taken under a physician's supervision. St. John's Wort may clash with other medications or ...

Meharry-Johns Hopkins Center for Prostate Cancer Research

DTIC Science & Technology

2014-08-01

and significance will be determined by a p-value less than 0.05. All analyses will be conducted using SAS version 9.1 (SAS Institute, Cary , NC...prostate cancer. · Each participant will receive a call from a trained interviewer who will ask questions about his health, health care, diet

Jasper Johns' Painted Words.

ERIC Educational Resources Information Center

Levinger, Esther

1989-01-01

States that the painted words in Jasper Johns' art act in two different capacities: concealed words partake in the artist's interrogation of visual perception; and visible painted words question classical representation. Argues that words are Johns' means of critiquing modernism. (RS)

Maniac Talk - John Mather

NASA Image and Video Library

2014-11-19

John Mather Maniac Lecture, November 19, 2014 Nobel Laureate John Mather presented a Maniac Talk entitled "Creating the Future: Building JWST, what it may find, and what comes next?" In this lecture, John takes a rear view look at how James Webb Space Telescope was started, what it can see and what it might discover. He describes the hardware, what it was designed to observe, and speculate about the surprises it might uncover. He also outlines a possible future of space observatories: what astronomers want to build, what we need to invent, and what they might find, even the chance of discovering life on planets around other stars.

John Dewey, an Appreciation

ERIC Educational Resources Information Center

Clopton, Robert W.

2015-01-01

The subject of the annual Presidential address of Phi Kappa Phi, presented on May 8, 1962, was John Dewey. Dewey is identified in the public mind chiefly as an educational philosopher. In this address, the author describes the life and work of John Dewey as an indefatigable student of life whose interests ranged, like those of Aristotle, over the…

Conceptions of Childhood in the Educational Philosophies of John Locke and John Dewey

ERIC Educational Resources Information Center

Bynum, Gregory Lewis

2015-01-01

This article compares progressive conceptions of childhood in the educational philosophies of John Locke and John Dewey. Although the lives of the two philosophers were separated by an ocean and two centuries of history, they had in common the following things: (1) a relatively high level of experience working with, and observing, children that is…

Celebrating John Glenn’s Legacy

NASA Image and Video Library

2012-03-02

Sen. John Glenn, left, shakes hands with former Astronaut Steve Lindsey as NASA Administrator Charles Bolden smiles at an event celebrating John Glenn's legacy and 50 years of americans in orbit held at the Cleveland State University Wolstein Center on Friday, March 3, 2012 in Cleveland, Ohio. In 1998 Lindsey flew onboard the space shuttle Discovery along with then 77 year-old Sen. John Glenn for the STS-95 mission. Glenn became the first American to orbit Earth in 1962. Photo Credit: (NASA/Bill Ingalls)

John Bahcall and the Solar Neutrino Problem

NASA Astrophysics Data System (ADS)

Bahcall, Neta

2016-03-01

``I feel like dancing'', cheered John Bahcall upon hearing the exciting news from the SNO experiment in 2001. The results confirmed, with remarkable accuracy, John's 40-year effort to predict the rate of neutrinos from the Sun based on sophisticated Solar models. What began in 1962 by John Bahcall and Ray Davis as a pioneering project to test and confirm how the Sun shines, quickly turned into a four-decade-long mystery of the `Solar Neutrino Problem': John's models predicted a higher rate of neutrinos than detected by Davis and follow-up experiments. Was the theory of the Sun wrong? Were John's calculations in error? Were the neutrino experiments wrong? John worked tirelessly to understand the physics behind the Solar Neutrino Problem; he led the efforts to greatly increase the accurately of the solar model, to understand its seismology and neutrino fluxes, to use the neutrino fluxes as a test for new physics, and to advocate for important new experiments. It slowly became clear that none of the then discussed possibilities --- error in the Solar model or neutrino experiments --- was the culprit. The SNO results revealed that John's calculations, and hence the theory of the Solar model, have been correct all along. Comparison of the data with John's theory demanded new physics --- neutrino oscillations. The Solar Neutrino saga is one of the most amazing scientific stories of the century: exploring a simple question of `How the Sun Shines?' led to the discovery of new physics. John's theoretical calculations are an integral part of this journey; they provide the foundation for the Solar Neutrino Problem, for confirming how the Sun shines, and for the need of neutrino oscillations. His tenacious persistence, dedication, enthusiasm and love for the project, and his leadership and advocacy of neutrino physics over many decades are a remarkable story of scientific triumph. I know John is smiling today.

Harvey Cushing at Johns Hopkins.

PubMed

Long, D M

1999-11-01

Harvey Cushing began surgical training with William Halsted at Johns Hopkins in 1896. Cushing joined the Johns Hopkins faculty in 1900 and spent 1 year in Europe in the laboratory of Theodore Kocher. He returned to Johns Hopkins, where he founded neurosurgery as an independent specialty, established the concept of the clinician scientist, discovered the hormonal properties of the pituitary gland and founded endocrinology, introduced intraoperative x-rays into surgical practice, introduced blood pressure monitoring into the operating room, and wrote the first definitive text on neurosurgery. Although there have been many pioneers in our field, Cushing, more than anyone else, developed neurosurgery as a specialty and left a legacy of talented neurosurgeons to develop and expand the field.

Marcel Breuer at Saint John's

ERIC Educational Resources Information Center

Carlson, Scott

2008-01-01

A visitor to Saint John's University and Saint John's Abbey, in north-central Minnesota, sees something of Gothic heritage while standing in front of the abbey church, designed and built around 1960. The church's 112-foot campanile--a trapezoidal slab made of 2,500 tons of steel and concrete--stands boldly in front of a huge concrete honeycomb…

Demythologizing John Dewey

ERIC Educational Resources Information Center

Bhattacharya, N. C.

1974-01-01

This article takes a brief but critical look at John Dewey's version of pragmatism, his contribution to philosophical scholarship generally as well as his theory and practice of liberalism. (Author/RK)

Annual Advances in Cancer Prevention Lecture | Division of Cancer Prevention

Cancer.gov

2018 Keynote Lecture Successes and Challenges of Vaccines to Prevent HPV-associated Cancers | John T. Schiller, PhD will present the keynote lecture entitled, "Successes and Challenges of Vaccines to Prevent HPV-associated Cancers" on July 24th at NIH Main Campus, Natcher Auditorium, Building 45, from 1:00 PM - 2:00 PM EDT.

John Leask Lumley: Whither Turbulence?

NASA Astrophysics Data System (ADS)

Leibovich, Sidney; Warhaft, Zellman

2018-01-01

John Lumley's contributions to the theory, modeling, and experiments on turbulent flows played a seminal role in the advancement of our understanding of this subject in the second half of the twentieth century. We discuss John's career and his personal style, including his love and deep knowledge of vintage wine and vintage cars. His intellectual contributions range from abstract theory to applied engineering. Here we discuss some of his major advances, focusing on second-order modeling, proper orthogonal decomposition, path-breaking experiments, research on geophysical turbulence, and important contributions to the understanding of drag reduction. John Lumley was also an influential teacher whose books and films have molded generations of students. These and other aspects of his professional career are described.

Logos Announced the Light of Salvation: Interpreting How John Presented His Message in John 1:1-18, According to Functional Grammar

ERIC Educational Resources Information Center

Pollinger, Seth

2014-01-01

This study of John 1:1-18 describes how John (the speaker) presented his message to his audience within their activity of verbal communication. By focusing on verbal meaning, this interpretation analyzes how John presented and expressed his meanings through language by interpreting this text based on the seamless interrelation between John's…

Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

ERIC Educational Resources Information Center

Mullen, Carol A.

2006-01-01

This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

ERIC Educational Resources Information Center

Mullen, Carol A.

2009-01-01

This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

Bringing global cancer leaders together at the 4th Annual Symposium on Global Cancer Research

Cancer.gov

The Annual Symposium on Global Cancer Research held in April 2016 was developed with a special focus on innovative and low-cost technologies in global cancer control, and brought inspiring keynote speakers such as John Seffrin, Former CEO of the American Cancer Society, and Tom Bollyky, Senior Fellow for Global Health at the Council on Foreign Relations.

Celebrating John Glenn’s Legacy

NASA Image and Video Library

2012-03-02

Former NASA Astronaut Steve Lindsey gives remarks at an event celebrating John Glenn's legacy and 50 years of americans in orbit held at the Cleveland State University Wolstein Center on Friday, March 3, 2012 in Cleveland, Ohio. In 1998 Lindsey flew onboard the space shuttle Discovery along with then 77 year-old Sen. John Glenn for the STS-95 mission. Glenn became the first American to orbit Earth in 1962. Photo Credit: (NASA/Bill Ingalls)

Celebrating John Glenn’s Legacy

NASA Image and Video Library

2012-03-02

Wife of former astronaut and Senator John Glenn, Annie Glenn, listens intently to Cleveland State University Master of Music Major James Binion Jr. as he sings a musical tribute during an event celebrating John Glenn's legacy and 50 years of americans in orbit held at the university's Wolstein Center on Friday, March 3, 2012 in Cleveland, Ohio. Glenn became the first American to orbit Earth in 1962. Photo Credit: (NASA/Bill Ingalls)

Obituary: John Leroy Climenhaga, 1916-2008

NASA Astrophysics Data System (ADS)

Scarfe, Colin

2009-01-01

John Leroy Climenhaga was born on 7 November 1916 on a farm some 10 km from Delisle, a small town on the Canadian prairies, located about 50 km south-west of Saskatoon, Saskatchewan, and died at his home in Victoria, British Columbia, on 27 May 2008. His parents, Reuben and Elizabeth (nee Bert) Climenhaga, were farming folk, and he carried their honest and open attitude to the world throughout his life. John was the seventh born, and last to die, of their ten children. His father also served as an ordained minister of the Brethren in Christ. In early adulthood, John worked on his father's farm, but then attended the University of Saskatchewan, obtaining a B.A. with Honors in Mathematics and Physics and an M.A. in Physics, in 1945 and 1949 respectively. Between these events he worked as a Physics Instructor at Regina College from 1946 to 1948. In 1949 Climenhaga joined the faculty of Victoria College, as one of only two physicists in a small institution that was then part of the University of British Columbia. He remained in Victoria for the rest of his career, playing a major role in the College's growth into a full-fledged university, complete with thriving graduate programs in physics and astronomy as well as in many other fields. He served as Head of the Physics Department during the 1960s, a period which saw the College become the University of Victoria, with a full undergraduate program in Physics, and campaigned successfully for the establishment of a program in Astronomy, which began in 1965. From 1969 until 1972 he held the position of Dean of Arts and Science, and championed the university's participation in the Tri-University Meson Facility, whose high-current medium-energy beam was ideal for the production and study of mesons and their physics. That period was a turbulent one in the university's history, but John's integrity and his balanced and fair-minded approach to conflicts were of immeasurable importance in steering the young institution through it

Training Postbac JHU | Center for Cancer Research

Cancer.gov

The Johns Hopkins University and the Center for Cancer Research (CCR) at the National Cancer Institute (NCI) have partnered to create a new concentration in the Master of Science in Biotechnology program, called

Aflatoxin: An Old Carcinogen Teaches Us New Tricks | Division of Cancer Prevention

Cancer.gov

Speaker John D. Groopman, PhD Anna M. Baetjer Professor of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Associate Director for Population Sciences Sidney Kimmel Comprehensive Cancer Center Johns Hopkins School of Medicine Baltimore, MD |

John N Bahcall (1934 2005)

NASA Astrophysics Data System (ADS)

Bergström, Lars; Botner, Olga; Carlson, Per; Hulth, Per Olof; Ohlsson, Tommy

2005-01-01

John Norris Bahcall, passed away on August 17, 2005, in NewYork City, USA. He was born on December 30, 1934, in Shreveport, Louisiana, USA. He was Richard Black Professor of Astrophysics in the School of Natural Sciences at the Institute forAdvanced Study (IAS) in Princeton, New Jersey, USA and a recipient of the National Medal of Science. In addition, he was President of the American Astronomical Society, President-Elect of the American Physical Society, and a prominent leader of the astrophysics community. John had a long and prolific career in astronomy and astrophysics, spanning five decades and the publication of more than five hundred technical articles, books, and popular papers. John's most recognized scientific contribution was the novel proposal in 1964, together with Raymond Davis Jr, that scientific mysteries of our Sun `how it shines, how old it is, how hot it is' could be examined by measuring the number of neutrinos arriving on Earth from the Sun. Measuring the properties of these neutrinos tests both our understanding of how stars shine and our understanding of fundamental particle physics. However, in the 1960s and 1970s, the observations by Raymond Davis Jr showed a clear discrepancy between John's theoretical predictions, based on standard solar and particle physics models, and what was experimentally measured. This discrepancy, known as the `Solar Neutrino Problem', was examined by hundreds of physicists, chemists, and astronomers over the subsequent three decades. In the late 1990s through 2002, new large-scale neutrino experiments in Japan, Canada, Italy, and Russia culminated in the conclusion that the discrepancy between John's theoretical predictions and the experimental results required a modification of our understanding of particle physics: neutrinos must have a mass and `oscillate' among different particle states. In addition to neutrino astrophysics, John contributed to many areas of astrophysics including the study of dark matter in

Obituary: John Louis Africano III, 1951-2006

NASA Astrophysics Data System (ADS)

Barker, Edwin, S.

2007-12-01

The orbital debris, space surveillance, and astronomical communities lost a valued and beloved friend when John L. Africano passed away on July 27, 2006, at the young age of 55. John passed away in Honolulu, Hawaii, from complications following a heart attack suffered while playing racquetball, which was his avocation in life. Born on February 8, 1951, in Saint Louis, Missouri, John graduated with a B.S. in Physics from the University of Missouri at Saint Louis in 1973, and received a Master's degree in Astronomy from Vanderbilt University in 1974. John had a real love for astronomical observing and for conveying his many years of experience to others. He encouraged many young astronomers and mentored them in the basics of photometry and astronomical instrumentation. John was author or co-author on nearly one-hundred refereed publications ranging from analyses of cool stars to the timing of occultations to space surveillance. He was honored for his contributions to minor planet research when the Jet Propulsion Laboratory named Minor Planet 6391 (Africano) after him. John held operational staff positions at several major observatories including McDonald Observatory in Texas, Kitt Peak National Observatory in Arizona, and the Cloudcroft Telescope Facility in New Mexico. He observed at numerous observatories worldwide, including Cerro Tololo Inter-American Observatory (CTIO) in Chile, developing a world-wide network of friends and colleagues. John's ability to build diverse teams through his managerial and technical skills, not to mention his smiling personality, resulted in numerous successes in the observational astronomy and space surveillance arenas. As an astronomer for Boeing LTS Inc., he worked for many years at the Advanced Maui Optical and Space Surveillance site (AMOS) on Maui, Hawaii, where he contributed his operational and instrumental expertise to both the astronomy and space surveillance communities. He was also the co-organizer of the annual AMOS

John locke on personal identity.

PubMed

Nimbalkar, Namita

2011-01-01

John Locke speaks of personal identity and survival of consciousness after death. A criterion of personal identity through time is given. Such a criterion specifies, insofar as that is possible, the necessary and sufficient conditions for the survival of persons. John Locke holds that personal identity is a matter of psychological continuity. He considered personal identity (or the self) to be founded on consciousness (viz. memory), and not on the substance of either the soul or the body.

SETI group let by Barney Oliver, John Wolfe and John Billingham (in middle standing) lead a 1976

NASA Technical Reports Server (NTRS)

1976-01-01

SETI group let by Barney Oliver, John Wolfe and John Billingham (in middle standing) lead a 1976 discussion on the best strategies in the Search for Extraterrestrial Intelligence. Joining the discussion are L-R; Charles Seeger, Dario Black, Mary Connors, (Oliver, Wolfe, Billingham) and Larry Lesyna, (seated) Mark Stull.

Celebrating John Glenn’s Legacy

NASA Image and Video Library

2012-03-02

Cleveland State University Master of Music Major James Binion Jr. sings a musical tribute during an event celebrating John Glenn's legacy and 50 years of americans in orbit held at the university's Wolstein Center on Friday, March 3, 2012 in Cleveland, Ohio. In 1998 Lindsey flew onboard the space shuttle Discovery along with then 77 year-old Sen. John Glenn for the STS-95 mission. Glenn became the first American to orbit Earth in 1962. Photo Credit: (NASA/Bill Ingalls)

A to Z with Jasper Johns

ERIC Educational Resources Information Center

Kirker, Sara Schmickle

2008-01-01

One contemporary artist that kindergarten students can easily relate to is Jasper Johns. In this article, the author discusses how she introduced John's numeric and alphabetic paintings to her kindergarten students. The young artists were amazed that art can be created from the familiar symbols that they are learning to make in their regular…

Effects of sunscreen on skin cancer and photoaging.

PubMed

Iannacone, Michelle R; Hughes, Maria Celia B; Green, Adèle C

2014-01-01

Application of sunscreen to the skin is widely used as an adjunct strategy, along with wearing protective clothing and seeking shade, to protect against skin cancer and photoaging that result from excessive sun exposure. Many epidemiological studies of case-control and cohort study design have studied the effects of sunscreen use on skin cancer, and more recently photoaging, but their findings have been mostly uninformative. This review of results of randomized controlled trials shows that the evidence, though limited, supports beneficial effects of sunscreen application on the occurrence of skin cancers and skin photoaging. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

John Henry--The Steel Driving Man

ERIC Educational Resources Information Center

Murphy, David E.; Gulley, Laura L.

2005-01-01

The story of John Henry provided the setting for sixth-grade class to participate in a John Henry Day of mathematics experiments. The students collected data from experiments where students competed against machines and technology. The student analyzed the data by comparing two box plots, a box plot of human data, and a box plot of machine or…

John C. Mather, the Big Bang, and the COBE

Science.gov Websites

Additional Information * Videos John C. Mather Courtesy of NASA "Dr. John C. Mather of NASA's Goddard excerpt from NASA Scientist Shares Nobel Prize for Physics 2Edited excerpt from John Mather: The Path to a Spacecraft Courtesy of Lawrence Berkeley National Laboratory Additional Web Pages: Dr. John C Mather, NASA

33 CFR 110.183 - St. Johns River, Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Johns River, Florida. 110.183... ANCHORAGE REGULATIONS Anchorage Grounds § 110.183 St. Johns River, Florida. (a) The anchorage grounds—(1... anchor in the St. Johns River, as depicted on NOAA chart 11491, between the entrance buoy (STJ) and the...

'Pinning and flux dynamics I' in the memory of Professor John Clem

NASA Astrophysics Data System (ADS)

Weber, Harald W.

2014-04-01

their home and at barbecues during the hot and humid evenings of typical Iowa summer days. We were sometimes lucky in persuading John to sing for us in his beautiful baritone. He performed regularly at special events in the Church or at ISU's Musica Antiqua. We all got to know their children, Paul and Jean, and followed their development with great pleasure. Paul became a well known physicist himself. With the advent of high temperature superconductivity, John played a leading role worldwide, as the editor and heart of the famous 'High-Tc Update' and as the author of fundamental papers on the subject. He was certainly the most sought-after invited or plenary speaker, both at small workshops and at huge international conferences; and each of his lectures was certainly to the point and enlightening! As fate unfortunately hit the Clem family in 2001 and Judy became completely paralyzed after brain tumor surgery, John took early retirement in order to be at home and to take care of his beloved wife. However, in 2009 he too received bad news as he was diagnosed with 'mesothelioma', a type of lung cancer, which he thought he may have contracted as a youngster working with asbestos during the school holidays. He lost this battle on 2 August 2013. John, we'll miss you and we'll certainly remember you with the greatest respect for your science and with great love for your warm and charming personality. Genova, 18 September 2013

33 CFR 110.73 - St. Johns River, Fla.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Johns River, Fla. 110.73... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.73 St. Johns River, Fla. (a) Area A. The waters lying within an area bounded by a line beginning at a point located at the west bank of St. Johns River at...

Screening adherence and cancer risk perceptions in colorectal cancer survivors with Lynch-like syndrome.

PubMed

Katz, L H; Burton-Chase, A M; Advani, S; Fellman, B; Polivka, K M; Yuan, Y; Lynch, P M; Peterson, S K

2016-03-01

Cancer screening recommendations for patients with Lynch-like syndrome (LLS) are not well defined. We evaluated adherence to Lynch syndrome (LS) screening recommendations, cancer risk perceptions, and communication within the families among colorectal cancer (CRC) survivors with LLS. Thirty-four participants with LLS completed a questionnaire about risk perception, adherence to LS screening recommendations, and communication with relatives. Clinical data were obtained from medical records. Most participants (76%) believed they should undergo colonoscopy every 1-2 years. Only 41% correctly interpreted their genetic tests as uninformative negative or as variant of unknown significance for LS. Less than half had had an upper gastrointestinal endoscopy for screening purpose. Among female participants, 86% had been screened for endometrial cancer (EC) and 71% for ovarian cancer. Most participants had informed relatives about the CRC diagnosis and advised them to undergo CRC screening, but only 50% advised female relatives to be screened for EC and only one-third advised relatives to have genetic counseling. Most CRC survivors with LLS follow the same cancer screening recommended for LS patients but do not understand the meaning of LLS. Greater care must be devoted to communicating the implications of nondiagnostic germline mutation testing among patients with LLS. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

46 CFR 7.90 - St. Johns River, FL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false St. Johns River, FL. 7.90 Section 7.90 Shipping COAST... § 7.90 St. Johns River, FL. A line drawn from the southeasternmost extremity of Little Talbot (Spike) Island to latitude 30°23.8′ N. longitude 81°20.3′ W. (St. Johns Lighted Whistle Buoy “2 STJ”); thence to...

St. John's wort: a new alternative for depression?

PubMed

Josey, E S; Tackett, R L

1999-03-01

The primary purpose of this article is to review the existing literature concerning the therapeutic uses, adverse effects, and possible drug interactions of St. John's wort (Hypericum perforatum) as compared to other antidepressant medications. Reference material was obtained through database searches with time restrictions of 1985 to the present. Studies selected were those written in the English language which compared the role of St. John's wort, tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin-selective reuptake inhibitors in the treatment of depression. Other studies were selected based on their evaluation of the safety and efficacy of St. John's wort as an antidepressant for a minimum of four weeks. A review of existing literature recognized nine clinical trials that reported the efficacy of St. John's wort as compared to placebo and to other antidepressant medications. Of these nine, four controlled studies were chosen based upon their large patient populations and their consistency in brand and dosage of St. John's wort used. These four studies demonstrated that St. John's wort was as effective as other antidepressant medications and more effective than placebo, as the clinical symptoms of depression greatly decreased upon administration of H. perforatum. The side-effect profile of H. perforatum at this time appears to be superior to any current U.S.-approved antidepressant medication. From the existing literature, St. John's wort appears to be a safe and effective alternative in the treatment of depression. Tricylic antidepressants and monoamine oxidase inhibitors can produce serious cardiac side-effects, such as tachycardia and postural hypotension, and many unwanted anticholinergic side-effects, including dry mouth and constipation. St. John's wort has proven to be free of any cardiac, as well as anticholinergic, side-effects normally seen with antidepressant medications. Based upon limited studies, St. John's wort appears to be an

John Carroll University

ERIC Educational Resources Information Center

Dean, Kathleen Lis; Rombalski, Patrick; O'Dell, Kyle

2009-01-01

John Carroll University (JCU) is a Jesuit Catholic institution located in University Heights, approximately 10 miles east of Cleveland, Ohio. Founded in 1888, the university has a population of 3,400 undergraduates and 800 graduate students. The Division of Student Affairs at JCU comprises 11 units. The mission of the division is the same as that…

33 CFR 117.325 - St. Johns River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Johns River. 117.325 Section 117.325 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.325 St. Johns River. (a) The drawspan...

Measuring cancer evolution from the genome.

PubMed

Graham, Trevor A; Sottoriva, Andrea

2017-01-01

The temporal dynamics of cancer evolution remain elusive, because it is impractical to longitudinally observe cancers unperturbed by treatment. Consequently, our knowledge of how cancers grow largely derives from inferences made from a single point in time - the endpoint in the cancer's evolution, when it is removed from the body and studied in the laboratory. Fortuitously however, the cancer genome, by virtue of ongoing mutations that uniquely mark clonal lineages within the tumour, provides a rich, yet surreptitious, record of cancer development. In this review, we describe how a cancer's genome can be analysed to reveal the temporal history of mutation and selection, and discuss why both selective and neutral evolution feature prominently in carcinogenesis. We argue that selection in cancer can only be properly studied once we have some understanding of what the absence of selection looks like. We review the data describing punctuated evolution in cancer, and reason that punctuated phenotype evolution is consistent with both gradual and punctuated genome evolution. We conclude that, to map and predict evolutionary trajectories during carcinogenesis, it is critical to better understand the relationship between genotype change and phenotype change. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Obituary: John J. Hillman, 1938-2006

NASA Astrophysics Data System (ADS)

Chanover, Nancy

2007-12-01

John J. Hillman, a dedicated NASA civil servant, spectroscopist, astrophysicist, planetary scientist, and mentor, died on February 12, 2006 of ocular melanoma at his home in Columbia, Maryland. His professional and personal interests were wide-reaching and varied, and he devoted his career to the advancement of our understanding of the beauty and wonder in the world around us. His love of nature, art, and science made him a true Renaissance man. John was born in Fort Jay, New York, on November 22, 1938, and was raised in Washington, D.C. He received his B.S., M.S., and Ph.D. degrees in Physics from American University in 1967, 1970, and 1975, respectively. He began working at NASA's Goddard Space Flight Center, then in its infancy, in 1969, juggling a full-time position as a Research Physicist, the completion of his M.S. and Ph.D. degrees, and a young family. His background in molecular spectroscopy enabled him to apply his skills to numerous disciplines within NASA: infrared and radio astronomy; electronic, vibrational, and rotational structure of interstellar molecules; solar and stellar atmospheres; and planetary atmospheres. He published more than 70 journal papers in these disciplines. He was a frequent contributor to the Ohio State University International Symposium on Molecular Spectroscopy, and possessed a rare ability to bridge the gap between laboratory and remote sensing spectroscopy, bringing scientists from different disciplines together to understand our Universe. The last fifteen years of John's career were devoted to the development of acousto-optic tunable filter (AOTF) cameras. He championed this technology as a low-cost, low-power alternative to traditional imaging cameras for in situ or remotely sensed planetary exploration. It was within this context that I got to know John, and eventually worked closely with him on the demonstration and application of this technology for planetary science using ground-based telescopes in New Mexico, California

Can exercise change the stereotypes associated with individuals with cancer?

PubMed

Clément-Guillotin, C; Falzon, C; d'Arripe-Longueville, F

2015-08-01

The purpose of this study was to examine whether exercising can positively influence the stereotypes associated with individuals with cancer and, more specifically, have an effect on the impression formation related to warmth and competence. A total of 193 French college students (Mage  = 21.08, SD = 1.44 years; 88 females and 105 males) were randomly assigned to one of the conditions of a 2 (participant sex) × 2 (target health status: cancer vs no information) × 3 (target exercise status: exerciser vs non-exerciser vs no information) experimental design. Results indicated that exercising target with cancer was perceived as the most competent compared with targets with cancer and those without information about cancer. These results suggest that exercising could be an effective way to undermine cancer stereotypes and reduce discrimination against people with cancer. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

CPTAC Team Releases Targeted Proteomic Assays for Ovarian Cancer | Office of Cancer Clinical Proteomics Research

Cancer.gov

Pacific Northwest National Laboratory (PNNL) investigators in the Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the National Cancer Institute (NCI), announces the public release of 98 targeted mass spectrometry-based assays for ovarian cancer research studies.  Chosen based on proteogenomic observations from the recently published multi-institutional collaborative project between PNNL and Johns Hopkins University that comprehensively examined the collections of proteins in the tumors of ovarian cancer patients (highlighted in a paper in

In memoriam - John M. Young (1942-2013)

USDA-ARS?s Scientific Manuscript database

It is with sadness that friends and colleagues of John Young learnt of his death at home in Auckland, New Zealand on 30th September 2013. John began his scientific career at the Plant Diseases Division (PDD) of the Department of Scientific and Industrial Research (DSIR), New Zealand after completing...

Candida virulence and ethanol-derived acetaldehyde production in oral cancer and non-cancer subjects.

PubMed

Alnuaimi, A D; Ramdzan, A N; Wiesenfeld, D; O'Brien-Simpson, N M; Kolev, S D; Reynolds, E C; McCullough, M J

2016-11-01

To compare biofilm-forming ability, hydrolytic enzymes and ethanol-derived acetaldehyde production of oral Candida isolated from the patients with oral cancer and matched non-oral cancer. Fungal biofilms were grown in RPMI-1640 medium, and biofilm mass and biofilm activity were assessed using crystal violet staining and XTT salt reduction assays, respectively. Phospholipase, proteinase, and esterase production were measured using agar plate method, while fungal acetaldehyde production was assessed via gas chromatography. Candida isolated from patients with oral cancer demonstrated significantly higher biofilm mass (P = 0.031), biofilm metabolic activity (P < 0.001), phospholipase (P = 0.002), and proteinase (P = 0.0159) activity than isolates from patients with non-oral cancer. High ethanol-derived acetaldehyde-producing Candida were more prevalent in patients with oral cancer than non-oral cancer (P = 0.01). In univariate regression analysis, high biofilm mass (P = 0.03) and biofilm metabolic activity (P < 0.001), high phospholipase (P = 0.003), and acetaldehyde production ability (0.01) were significant risk factors for oral cancer; while in the multivariate regression analysis, high biofilm activity (0.01) and phospholipase (P = 0.01) were significantly positive influencing factors on oral cancer. These data suggest a significant positive association between the ability of Candida isolates to form biofilms, to produce hydrolytic enzymes, and to metabolize alcohol to acetaldehyde with their ability to promote oral cancer development. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Englerin A Delivers One-Two Punch to Kidney Cancer Cells | Center for Cancer Research

Cancer.gov

While overall cancer death rates continue to decline in the U.S., mortality rates for certain cancer sites, including the kidney, are on the rise. New treatments are needed to reverse this trend and one potentially rich source is natural products, compounds derived from living organisms. John Beutler, Ph.D., and his colleagues, in CCR’s Molecular Targets Laboratory located at

Effects of Saint John’s Wort and Vitamin E on Breast Cancer Chemotherapeutic Agents

DTIC Science & Technology

2005-05-01

studies of St. John’s wort. However, because some recent studies have identified hyperforin as a more important contributor to the pharmacological...actions of this herbal product (3), we have employed an HPLC analytical method that accurately detects and determines hyperforin . iii. As reported...the diet are not significantly different from rats maintained on the standard diet. After 2 weeks on the diet, the rats were found to have hyperforin

John Kotter on Leadership, Management and Change.

ERIC Educational Resources Information Center

Bencivenga, Jim

2002-01-01

Excerpts from interview with John Kotter, Konosuke Matsushita Professor of Leadership at the Harvard Business School, about his thoughts on the role of the superintendent as leader and manager. Describes his recent book "John P. Kotter on What Leaders Really Do," 1999. Lists eight-step change process from his book "Leading Change," 1996. (PKP)

Struggle for the Soul: John Lawrence Childs

ERIC Educational Resources Information Center

Stallones, Jared

2010-01-01

John Lawrence Childs was born in Eau Claire, Wisconsin on January 11, 1889, the second child of John Nelson Childs and Helen Janette (Nettie) Smith. In childhood Childs absorbed the values of industry, democracy, and a traditional, but socially conscious, religion. Childs was a Methodist and an intensely private person not given to talking about…

In memoriam: John Warren Aldrich, 1906-1995

USGS Publications Warehouse

Banks, Richard C.

1997-01-01

John Aldrich was born in Providence, Rhode Island, on 23 February 1906, and went to the Providence public schools. He developed a broad interest in natural history at an early age, being stimulated by his mother, a kindergarten teacher, who introduced him to nature books. His interest was strengthened by Harold L. Madison, Director of the Park Museum in Providence, an Associate ( = member) of the AOU. As a high school student, John taught nature study at the Rhode Island Boy Scout Camp in summers. John was President of his class at Classical High School, and manager of the school's football team in his senior year. Also in that year, 1923, John published his first paper, a note in Bird-Lore on the occurrence of the Mockingbird in Rhode Island. That paper is a literary gem, showing that his skill in writing developed as early as his knowledge of birds. His early interest in football continued as well; he was a devoted fan of the Washington Redskins in his later years.

John Snow’s legacy: epidemiology without borders

PubMed Central

Fine, Paul; Victora, Cesar G; Rothman, Kenneth J; Moore, Patrick S; Chang, Yuan; Curtis, Val; Heymann, David L; Slutkin, Gary; May, Robert M; Patel, Vikram; Roberts, Ian; Wortley, Richard; Torgerson, Carole; Deaton, Angus

2013-01-01

This Review provides abstracts from a meeting held at the London School of Hygiene and Tropical Medicine, on April 11–12, 2013, to celebrate the legacy of John Snow. They describe conventional and unconventional applications of epidemiological methods to problems ranging from diarrhoeal disease, mental health, cancer, and accident care, to education, poverty, financial networks, crime, and violence. Common themes appear throughout, including recognition of the importance of Snow’s example, the philosophical and practical implications of assessment of causality, and an emphasis on the evaluation of preventive, ameliorative, and curative interventions, in a wide variety of medical and societal examples. Almost all self-described epidemiologists nowadays work within the health arena, and this is the focus of most of the societies, journals, and courses that carry the name epidemiology. The range of applications evident in these contributions might encourage some of these institutions to consider broadening their remits. In so doing, they may contribute more directly to, and learn from, non-health-related areas that use the language and methods of epidemiology to address many important problems now facing the world. PMID:23582396

Mouth cancer in inflammatory bowel diseases.

PubMed

Giagkou, E; Christodoulou, D K; Katsanos, K H

2016-05-01

Mouth cancer is a major health problem. Multiple risk factors for developing mouth cancer have been studied and include history of tobacco and alcohol abuse, age over 40, exposure to ultraviolet radiation, human papilloma virus infection (HPV), nutritional deficiencies, chronic irritation, and existence or oral potentially malignant lesions such as leukoplakia and lichen planus. An important risk factor for mouth cancer is chronic immunosuppression and has been extensively reported after solid organ transplantation as well as HIV-infected patients. Diagnosis of inflammatory bowel disease (IBD) is not yet considered as a risk factor for oral cancer development. However, a significant number of patients with IBD are receiving immunosuppressants and biological therapies which could represent potential oral oncogenic factors either by direct oncogenic effect or by continuous immunosuppression favoring carcinogenesis, especially in patients with HPV(+) IBD. Education on modifiable risk behaviors in patients with IBD is the cornerstone of prevention of mouth cancer. Oral screening should be performed for all patients with IBD, especially those who are about to start an immunosuppressant or a biologic. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Dedication: John Reuben Clark.

USDA-ARS?s Scientific Manuscript database

Volume 40 of Horticultural reviews is dedicated to John Reuben Clark (University of Arkansas) for his outstanding contributions to horticulture. While known particularly for his impact on blackberry, blueberry, table grape, and peach cultivar development, he has also been a strong and enthusiastic v...

Oral cancer awareness in Spain: A pilot study.

PubMed

Varela-Centelles, P; Estany-Gestal, A; Bugarín-González, R; Seoane-Romero, J M

2018-03-01

To investigate the level of oral cancer knowledge and awareness in a Spanish general population. A cross-sectional study using an anonymous questionnaire applied in the community to randomly selected laypersons. Sample size for the general population was determined by quota sampling, resulting in 1,041 individuals. A total of 1,707 pedestrians were approached (response: 61%). When the participants were asked about what cancers had they heard about (up to ten), oral cancer was mentioned in first place by 2% of the sample and by 22% in any order. When specifically asked about oral cancer, the percentage of interviewees who were familiar with it raised to 72%. Participants were also asked about the main signs or symptoms of oral cancer, and the most frequently (22%) mentioned as the first warning sign was a non-healing ulcer. Tobacco smoking generally was recognised as the most important (57%) risk factor for oral cancer. This pilot study revealed a low awareness of oral cancer, and a poor knowledge of its signs and symptoms and risk factors. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

John Dewey: Su filosofia y filosofia de la educacion (John Dewey: His Philosophy and Philosophy of Education). Working Paper.

ERIC Educational Resources Information Center

Zoreda, Margaret Lee

This paper forms part of an investigation about how the philosophy of John Dewey (1859-1952) can illuminate the practice of the teaching of English as a foreign language. The paper seeks to interpret and synthesize John Dewey's philosophical works to construct a "Deweyian lens" with which to analyze and evaluate the field of the teaching…

Breast Cancer Epidemiology in Puerto Rico

DTIC Science & Technology

2010-06-01

cancer epidemiology. Dr. Rosario took a course on Social Epidemiology at Johns Hopkins Bloomberg School of Public Health Baltimore, MD. June 29 to...July 3, 2009. This course offered an overview of conceptual and methodological approaches relevant to the study of the impact of social factors on...conference call. 2. Training: a. Courses: i. Attended a course on Social Epidemiology at Johns Hopkins Bloomberg School of Public Health

Photocopy of photograph (from Mrs. Martin, grandniece of John French, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (from Mrs. Martin, grandniece of John French, Clinton, Missouri) Circa 1900, photographer unknown JOHN AND ALMIRA FRENCH IN FRONT OF WEST AND SOUTH FACADES - John French Farm, South Grand River, Deepwater, Henry County, MO

Obituary: John Daniel Kraus, 1910-2004

NASA Astrophysics Data System (ADS)

Kraus, John D., Jr.; Marhefka, Ronald J.

2005-12-01

John Daniel Kraus, 94, of Delaware, Ohio, director of the Ohio State University "Big Ear" Radio Observatory, physicist, inventor, and environmentalist died 18 July 2004 at his home in Delaware, Ohio. He was born on 28 June 1910 in Ann Arbor, Michigan. He received a Bachelor of Science in 1930, a Master of Science in 1931, and a PhD in physics in 1933 (at 23 years of age), all from the University of Michigan, Ann Arbor. During the 1930s at Michigan, he was involved in physics projects, antenna consulting, and in atomic-particle-accelerator research using the University of Michigan's premier cyclotron. Throughout the late 1920s and the 1930s, John was an avid radio amateur with call sign W8JK. He was back on the air in the 1970s. In 2001 the amateur radio magazine CQ named him to the inaugural class of its Amateur Radio Hall of Fame. He developed many widely used innovative antennas. The "8JK closely spaced array" and the "corner reflector" were among his early designs. Edwin H. Armstrong wrote John in July 1941 indicating in part, "I have read with interest your article in the Proceedings of the Institute on the corner reflector...Please let me congratulate you on a very fine piece of work." Perhaps John's most famous invention, and a product of his intuitive reasoning process, is the helical antenna, widely used in space communications, on global positioning satellites, and for other applications. During World War II, John was in Washington, DC as a civilian scientist with the U.S. Navy responsible for "degaussing" the electromagnetic fields of steel ships to make them safe from magnetic mines. He also worked on radar countermeasures at Harvard University's Radio Research Laboratory. He received the U.S. Navy Meritorious Civilian Service Award for his war work. In 1946 he took a faculty position at Ohio State University, becoming professor in 1949, and retiring in 1980 as McDougal Professor Emeritus of Electrical Engineering and Astronomy. Even so, he never retired

Controversial role of mast cells in skin cancers.

PubMed

Varricchi, Gilda; Galdiero, Maria R; Marone, Giancarlo; Granata, Francescopaolo; Borriello, Francesco; Marone, Gianni

2017-01-01

Cancer development is a multistep process characterized by genetic and epigenetic alterations during tumor initiation and progression. The stromal microenvironment can promote tumor development. Mast cells, widely distributed throughout all tissues, are a stromal component of many solid and haematologic tumors. Mast cells can be found in human and mouse models of skin cancers such as melanoma, basal and squamous cell carcinomas, primary cutaneous lymphomas, haemangiomas and Merkel cell carcinoma. However, human and animal studies addressing potential functions of mast cells and their mediators in skin cancers have provided conflicting results. In several studies, mast cells play a pro-tumorigenic role, whereas in others, they play an anti-tumorigenic role. Other studies have failed to demonstrate a clear role for tumor-associated mast cells. Many unanswered questions need to be addressed before we understand whether tumor-associated mast cells are adversaries, allies or simply innocent bystanders in different types and subtypes of skin cancers. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

John Ross, Cherokee Chief.

ERIC Educational Resources Information Center

Moulton, Gary Evan

Emphasizing the dedication with which John Ross (1790-1866) labored to achieve Cherokee social and political cohesion, this biography details the historical and political events which influenced Ross's attempts to make the U.S. honor its treaty obligations and thwart the Federal "Removal Policy" (removal of American Indians from their…

75 FR 5803 - John Day/Snake Resource Advisory Council; Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

...] John Day/Snake Resource Advisory Council; Meetings AGENCY: Bureau of Land Management, Interior. ACTION: Meeting Notice for the John Day/Snake Resource Advisory Council. SUMMARY: Pursuant to the Federal Land..., Bureau of Land Management (BLM) John Day/Snake Resource Advisory Council (JDSRAC) will meet as indicated...

An assessment of oral cancer curricula in dental hygiene programmes: implications for cancer control.

PubMed

Thacker, K K; Kaste, L M; Homsi, K D; LeHew, C W

2016-11-01

To assess oral cancer prevention and early detection curricula in Illinois associate-degree dental hygiene programmes and highlight global health applications. An email invitation was sent to each Illinois associate-degree granting dental hygiene programme's oral cancer contact to participate in a survey via a SurveyMonkey™ link to a 21-item questionnaire. Questions elicited background information on each programme and inquired about curriculum and methods used for teaching oral cancer prevention and early detection. Eight of the 12 (67%) programmes responded. Three (37.5%) reported having a specific oral cancer curriculum. Five (62.5%) require students to perform examinations for signs and symptoms of oral cancer at each clinic visit. Variations exist across the programmes in the number of patients each student sees annually and the number of oral cancer examinations each student performs before graduation. Seven programmes (87.5%) conduct early detection screening in community settings. All programmes included risk assessment associated with tobacco. All other risk factors measured were treated inconsistently. Significant differences in training and experience were reported across Illinois dental hygiene programmes. Training is neither standardized nor uniformly comprehensive. Students' preparation for delivering prevention and early detection services to their patients could be strengthened to ensure competence including reflection of risk factors and behaviours in a global context. Regular review of curricular guidelines and programme content would help dental hygienists meet the expectations of the Crete Declaration on Oral Cancer Prevention. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Astronaut John H. Glenn

NASA Technical Reports Server (NTRS)

1959-01-01

Astronaut John H. Glenn, one of the original seven astronauts for Mercury Project selected by NASA on April 27, 1959. The MA-6 mission, boosted by the Mercury-Atlas vehicle, was the first manned orbital launch by the United States, and carried Astronaut Glenn aboard the Friendship 7 spacecraft to orbit the Earth.

Conversations with John Williams

ERIC Educational Resources Information Center

Sullivan, Jack

2007-01-01

In this article, the author shares the views of John Williams, Hollywood's premier composer, who has written more than 300 scores, about the future of classical and film music. A gregarious person in a field requiring monklike isolation, Williams values the "association with the soloists, and the wonderful inspiration from players." His…

Who Killed John Keats?

ERIC Educational Resources Information Center

Leal, Amy

2007-01-01

Two months before he died, John Keats claimed he had been poisoned. Although most scholars and biographers have attributed Keats's fears of persecution, betrayal, and murder to consumptive dementia, Keats's suspicions had begun long before 1820 and were not without some justification. In this article, the author talks about the death of John…

University of Texas Southwestern Medical Center: Lung Cancer Oncogenotype-Selective Drug Target Discovery (Natural Products Focus) | Office of Cancer Genomics

Cancer.gov

The goal of this project is to use small molecules and RNAi to functionally define subtypes of non-small cell lung cancer (NSCLC) using a panel of cell lines prepared and molecularly annotated by Drs. John Minna and Adi Gazdar. Experimental Approaches Lung Cancer Natural Products Screening/Chemical Library Screening

Chemistry of St. John's Wort: Hypericin and Hyperforin

ERIC Educational Resources Information Center

Vollmer, John J.; Rosenson, Jon

2004-01-01

The appeal as natural antidepressant is the major selling point of St. John's Wort, which is referred to as "Prozac from the plant kingdom". Hypericin and hyperforin, two major constituents with significant biological activity of St. John's Wort and which are complex molecules with unusual features, are examined.

The Inner Workings of Ovarian Cancer

ScienceCinema

Rodland, Karin

2018-06-12

New research identifies critical proteins present in the tumors of women with ovarian cancer. Karin Rodland discusses the work led by PNNL and Johns Hopkins researchers, working with collaborators across the nation.

33 CFR 110.73 - St. Johns River, Fla.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Johns River, Fla. 110.73 Section 110.73 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.73 St. Johns River, Fla. (a) Area A. The waters lying...

33 CFR 110.73 - St. Johns River, Fla.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false St. Johns River, Fla. 110.73 Section 110.73 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.73 St. Johns River, Fla. (a) Area A. The waters lying...

33 CFR 110.73 - St. Johns River, Fla.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false St. Johns River, Fla. 110.73 Section 110.73 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.73 St. Johns River, Fla. (a) Area A. The waters lying...

33 CFR 110.73 - St. Johns River, Fla.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false St. Johns River, Fla. 110.73 Section 110.73 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.73 St. Johns River, Fla. (a) Area A. The waters lying...

Talking theory, talking therapy: Emmy Gut and John Bowlby.

PubMed

Ross, Lynda R

2006-06-01

Emmy Gut was a psychotherapist who developed, in her later years, a unique theory distinguishing between "productive" and "unproductive" depression. Dr. John Bowlby was a leading psychoanalyst famous for his work on attachment theory. After the death of her second husband, Emmy contacted John because his work on mourning and grief spoke to her own depressed state. Although her views of the world and of her relationship with John were clearly coloured by bouts of depression, she was profoundly influenced by her personal, therapeutic, and intellectual involvement with him. Evidence of his influence is seen in the volumes of correspondence flowing between them beginning in 1971 and continuing until John's death in 1990. During that time, Emmy wrote more than 100-some very lengthy-letters to John. Much of her correspondence was devoted to discussions about their often ambiguous and conflicted therapeutic relationship. Through an analysis of attachment theory and the nature of the client-therapist alliance, this paper offers insights into the effects that imbalances in power, expectations, and shifting needs can play in the recovery process.

Does fear of cancer recurrence differ between cancer types? A study from the population-based PROFILES registry.

PubMed

van de Wal, Marieke; van de Poll-Franse, Lonneke; Prins, Judith; Gielissen, Marieke

2016-07-01

Knowledge of factors associated with fear of cancer recurrence (FCR) may inform intervention development and improve patient care. The aims were (1) to compare FCR severity between cancer types and (2) to identify associations between FCR, demographics, medical characteristics, information provision and health-related quality of life. Cross-sectional data were obtained from the Patient Reported Outcomes Following Initial Treatment and Long-Term Evaluation of Survivorship registry. We included stage I and II survivors diagnosed with melanoma (n = 469), colorectal cancer (n = 861), endometrial cancer (n = 688), thyroid cancer (n = 218), Hodgkin (n = 103) and non-Hodgkin lymphoma (n = 276). Cancer survivors completed questionnaires on FCR (Impact of Cancer scale - Health Worries subscale), satisfaction with information provision (European Organization for Research and Treatment of Cancer, Quality of Life Questionnaire (EORTC-QLQ) INFO25, satisfaction scale) and health-related quality of life (EORTC-QLQ C30, Short Form 36-item). A total of 2615 survivors completed the Impact of Cancer scale - Health Worries subscale. No significant differences in FCR severity were found between any of the cancer types (p = 0.063). A younger age, female gender, stage II disease, a shorter time since diagnosis, scheduled follow-up appointments and comorbidity were associated with higher FCR (p < 0.01). Satisfaction with information provision was negatively correlated with FCR severity (r = -0.16, p < 0.05). Demographic and medical factors accounted for 6% of explained variance in FCR. The full model, also including health-related quality of life, explained 15% and 19%, respectively. Fear of cancer recurrence seems to be a universal concern of cancer survivors rather than a cancer type-specific problem. Gender, age and medical factors were identified as risk factors. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

The relative importance of cancer-related and general health worries and distress among older adult, long-term cancer survivors.

PubMed

Deimling, Gary T; Brown, Sherri P; Albitz, Casey; Burant, Christopher J; Mallick, Nabeel

2017-02-01

This research examines the relative importance that cancer-related and non-cancer illness factors play in generating general health worries and/or cancer-related worries. The analysis also examines how these in turn impact anxiety and depression among older adult, long-term cancer survivors. Data from a longitudinal study of 245 older-adult (age 60+ years), long-term survivors (5 or more years after diagnosis) of breast, prostate, and colorectal cancer are examined to identify the measurement properties and structure of general health and cancer-related health worries. Based on that measurement analysis, structural equation models (SEM) are used to estimate the relative importance of cancer-related and other illness predictors on cancer-related worry and general health worry and how these two forms of worry affect both anxiety (POMS) and depression (CES-D). The results from the exploratory and confirmatory factor analysis of health worries identify two relatively independent measures of health worry, one of general health worry and a second of cancer-related worries that includes fears of recurrence, new cancers, and follow-up testing. SEM analyses identified the importance of current cancer-related symptoms and comorbidities on cancer-related worry. It also documents the primacy of non-cancer symptoms and general health worry as predictors of anxiety and depression among older survivors. The fact that cancer-related symptoms continue to be associated with cancer-related worries years after diagnosis speaks to the significance of these continuing sequelae. While the findings suggest the relative independence of cancer-related worries and general health worries, both are correlated with anxiety and depression. This may be particularly problematic as survivors age and symptoms related to new health problems increase, while cancer-related symptoms persist. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Peter Pindar (John Wolcot).

ERIC Educational Resources Information Center

Vales, Robert L.

This book is designed as an introduction to John Wolcot's works for the general reader, the college student, and the college teacher. Wolcot, whose pen name was Peter Pindar, wrote topical satire on public personalities of the eighteenth century, and his methods of criticism are the motif which guides each chapter and which unites all the satires…

Magic moments with John Bell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertlmann, Reinhold A.

John Bell, with whom I had a fruitful collaboration and warm friendship, is best known for his seminal work on the foundations of quantum physics, but he also made outstanding contributions to particle physics and accelerator physics.

University of Texas Southwestern Medical Center (UTSW): Lung Cancer Oncogenotype-Selective Drug Target Discovery (Natural Products Focus) | Office of Cancer Genomics

Cancer.gov

The goal of this project is to use small molecules and RNAi to functionally define subtypes of non-small cell lung cancer (NSCLC) using a panel of cell lines prepared and molecularly annotated by Drs. John Minna and Adi Gazdar. Experimental Approaches Lung Cancer Natural Products Screening/Chemical Library Screening

The perspective of prostate cancer patients and patients' partners on the psychological burden of androgen deprivation and the dyadic adjustment of prostate cancer couples.

PubMed

Hamilton, Lisa Dawn; Van Dam, Dexter; Wassersug, Richard J

2016-07-01

Prostate cancer and its treatments, particularly androgen deprivation therapy (ADT), affect both patients and partners. This study assessed how prostate cancer treatment type, patient mood, and sexual function related to dyadic adjustment from patient and partner perspectives. Men with prostate cancer (n = 206) and partners of men with prostate cancer (n = 66) completed an online survey assessing the patients' mood (profile of mood states short form), their dyadic adjustment (dyadic adjustment scale), and sexual function (expanded prostate cancer index composite). Analyses of covariance found that men on ADT reported better dyadic adjustment compared with men not on ADT. Erectile dysfunction was high for all patients, but a multivariate analysis of variance found that those on ADT experienced greater bother at loss of sexual function than patients not on ADT, suggesting that loss of libido when on ADT does not mitigate the psychological distress associated with loss of erections. In a multiple linear regression, patients' mood predicted their dyadic adjustment, such that worse mood was related to worse dyadic adjustment. However, more bother with patients' overall sexual function predicted lower relationship scores for the patients, while the patients' lack of sexual desire predicted lower dyadic adjustment for partners. Both patients and partners are impacted by the prostate cancer treatment effects on patients' psychological and sexual function. Our data help clarify the way that prostate cancer treatments can affect relationships and that loss of libido on ADT does not attenuate distress about erectile dysfunction. Understanding these changes may help patients and partners maintain a co-supportive relationship. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor

DTIC Science & Technology

2014-09-01

of DAB2IP in chemo- resistance of prostate cancer cells. Clin Cancer Res 2013;19:4740- 4749. POLYMERIC NANOPARTICLES FOR TARGETED... cancer , NU7441, Targeting John Wiley & Sons, Inc. Journal of Biomedical Materials Research: Part A 1 POLYMERIC NANOPARTICLES FOR TARGETED...The University of Texas Southwestern Medical Center, Dallas, TX, 75390 Running Title: Nanoparticles for radiosensitization of prostate cancer cells

Geology of St. John, U.S. Virgin Islands

USGS Publications Warehouse

Rankin, Douglas W.

2002-01-01

The rocks of St. John, which is located near the eastern end of the Greater Antilles and near the northeastern corner of the Caribbean plate, consist of Cretaceous basalt, andesite, keratophyre, their volcaniclastic and hypabyssal intrusive equivalents, and minor calcareous rocks and chert. These rocks were intruded by Tertiary mafic dikes and tonalitic plutons. The oldest rocks formed in an extensional oceanic environment characterized by abundant keratophyre and sheeted dikes. Subduction-related volcanism of the east-west-trending marine Greater Antilles volcanic arc began on St. John near the transition between the Early and Late Cretaceous. South-directed compression, probably caused by the initial collision between the Greater Antilles arc of the Caribbean plate and the Bahama platform of the North American plate, deformed the Cretaceous strata into east-west-trending folds with axial-plane cleavage. Late Eocene tonalitic intrusions, part of the Greater Antilles arc magmatism, produced a contact aureole that is as much as two kilometers wide and that partly annealed the axial-plane cleavage. East-west compression, possibly related to the relative eastward transport of the Caribbean plate in response to the beginning of spreading at the Cayman Trough, produced long-wavelength, low-amplitude folds whose axes plunge gently north and warp the earlier folds. A broad north-plunging syncline-anticline pair occupies most of St. John. The last tectonic event affecting St. John is recorded by a series of post-late Eocene sinistral strike-slip faults related to the early stages of spreading at the Cayman Trough spreading center and sinistral strike-slip accommodation near the northern border of the Caribbean plate. Central St. John is occupied by a rhomb horst bounded by two of these sinistral faults. Unlike other parts of the Greater Antilles, evidence for recent tectonic movement has not been observed on St. John.

John Hennessey, Barrier Breaker

ERIC Educational Resources Information Center

Nelson, Stephen J.

2018-01-01

John Hennessey lived a remarkable, full life as a professor, as a leader in his field of management and business, and moral, ethical leadership, and as dean at Dartmouth College's Tuck School of Business and provost at the University of Vermont. He was extraordinary on many fronts, a great man who lived in tumultuous times marked by world war as a…

Factors influencing health-related quality of life among Korean cancer survivors.

PubMed

Kim, KiSook; Kim, Ji-Su

2017-01-01

Early cancer detection and remarkable improvements in cancer treatment have seen the cancer survival rate grow steadily for the past 40 years. Despite expectations regarding treatment effectiveness, acceptable quality of life, and a comfortable death, patients with cancer generally have a decreased quality of life. The study aim was to examine the factors influencing health-related quality of life among South Korean cancer survivors for future development of an intervention to enhance their survivorship. Korea National Health and Nutrition Examination Survey 2008-2012 data regarding 1020 cancer survivors were used for analysis. Health-related quality of life was measured using the EuroQol 5-Dimension. The factors influencing health-related quality of life were age, educational status, employment status, income, smoking, time since diagnosis, subjective health status, stress, depression, and suicidal ideation. Individual-centered clinical interventions that consider dimensional-influencing factors, including subjective health status, are needed to improve cancer survivors' health-related quality of life. Subsequent systematic studies are needed regarding dimension-specific differences according to cancer types and time since diagnosis. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

John Bell (1763-1820): brother artist and anatomist.

PubMed

Gardner-Thorpe, Christopher

2013-01-01

John Bell, brother-surgeon of Charles Bell, was, like Charles, an outstanding surgeon and a good artist. John was one of the few who illustrated his work with their own drawings in the days before audiovisual aids were available and without the benefit of reliable drawing aids, photography and computer-aided design. Charles, on the other hand, was the better artist and illustrated much of the normal anatomy of the nervous system. Each brother undertook extensive surgery of men who had been wounded in war; John Bell left us his engravings from the textbooks, more numerous perhaps than Charles, but Charles left us a series of oil paintings and watercolours in addition to the illustrations in his textbooks. © 2013 Elsevier B.V. All rights reserved.

Using Mechanical Turk for research on cancer survivors.

PubMed

Arch, Joanna J; Carr, Alaina L

2017-10-01

The successful recruitment and study of cancer survivors within psycho-oncology research can be challenging, time-consuming, and expensive, particularly for key subgroups such as young adult cancer survivors. Online crowdsourcing platforms offer a potential solution that has not yet been investigated with regard to cancer populations. The current study assessed the presence of cancer survivors on Amazon's Mechanical Turk (MTurk) and the feasibility of using MTurk as an efficient, cost-effective, and reliable psycho-oncology recruitment and research platform. During a <4-month period, cancer survivors living in the United States were recruited on MTurk to complete two assessments, spaced 1 week apart, relating to psychosocial and cancer-related functioning. The reliability and validity of responses were investigated. Within a <4-month period, 464 self-identified cancer survivors on MTurk consented to and completed an online assessment. The vast majority (79.09%) provided reliable and valid study data according to multiple indices. The sample was highly diverse in terms of U.S. geography, socioeconomic status, and cancer type, and reflected a particularly strong presence of distressed and young adult cancer survivors (median age = 36 years). A majority of participants (58.19%) responded to a second survey sent one week later. Online crowdsourcing represents a feasible, efficient, and cost-effective recruitment and research platform for cancer survivors, particularly for young adult cancer survivors and those with significant distress. We discuss remaining challenges and future recommendations. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

A New Reading of Shakespeare's King John.

NASA Astrophysics Data System (ADS)

Usher, Peter D.

1995-12-01

Shakespeare wrote King John c.1594, six years after the defeat of the Spanish Armada, and ~ 50 years after publication of the Copernican heliocentric hypothesis. It is said to be the most unhistorical of the History Plays, ``anomalous'', ``puzzling'', and ``odd'', and as such it has engendered far more than the customary range of interpretive opinion. I suggest that the play alerts Elizabethans not just to military and political threats, but to a changing cosmic world view, all especially threatening as they arise in Catholic countries. (a) Personification characterizes the play. John personifies the old order, while Arthur and the Dauphin's armies personify the new. I suggest that Shakespeare decenters King John just as Copernicus decentered the world. (b) Hubert menaces Arthur's eyes for a whole scene (4.1), but the need for such cruelty is not explained and is especially odd as Arthur is already under sentence of death (3.3.65-66). This hitherto unexplained anomaly suggests that the old order fears what the new might see. (c) Eleanor's confession is made only to Heaven and to her son the King (1.1.42-43), yet by echoing and word play the Messenger from France later reveals to John that he is privy to it (4.2.119-124). This circumstance has not been questioned heretofore. I suggest that the Messenger is like the wily Hermes (Mercury), chief communicator of the gods and patron of the sciences; by revealing that he moves in the highest circles, he tells John that he speaks with an authority that transcends even that of a king. The message from on high presages more than political change; it warns of a new cosmic and religious world order (d) Most agree that John is a weak king, so Shakespeare must have suspected flaws in the old ways. He would have known that Tycho Brahe's new star of 1572, the comet of 1577, and the 1576 model of his compatriot Thomas Digges, were shattering old ideas. (e) The tensions of the play are not resolved because in 1594 the new order was

Mesenchymal Stem Cell Based Therapy for Prostate Cancer

DTIC Science & Technology

2015-11-01

Award Number: W81XWH-13-1-0304 TITLE: Mesenchymal Stem Cell-Based Therapy for Prostate Cancer PRINCIPAL INVESTIGATOR: John Isaacs CONTRACTING...TITLE AND SUBTITLE Mesenchymal Stem Cell-Based Therapy for Prostate Cancer 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-13-1-0304 5c. PROGRAM ELEMENT...effective therapy for castrate resistant metastatic prostate cancer (CRPC). Based upon a substantial published literature from multiple groups, as well as

Cancer literacy as a mediator for cancer screening behaviour in Korean adults.

PubMed

Lee, Hee Yun; Rhee, Taeho Greg; Kim, Nam Keol

2016-09-01

This study investigates the cancer literacy level in Korean adults and examines whether cancer literacy plays a mediating role in the relationship between population characteristics and cancer screening behaviours. We collected data from 585 community-dwelling adults in Korea using self-administered surveys and face-to-face interviews from October to December in 2009. Guided by Andersen's behavioural model, we used a structural equation model to estimate the effect of cancer literacy as a mediator and found that cancer literacy mediated cancer screening behaviour. In the individual path analysis models, cancer literacy played a significant mediating role for the use of eastern medicine, fatalism, health status and the number of chronic diseases. When controlling for other relevant covariates, we found that in the optimal path model, cancer literacy played a mediating role in the relationship between the use of eastern medicine and self-rated health status as well as cancer screening behaviour. Thus, developing community-based cancer education programmes and training clinical practitioners in eastern medicine clinics about the importance of informing their patients about regular cancer screening may be an option to boost cancer literacy and screening behaviour in Korea. © 2015 John Wiley & Sons Ltd.

Oral cancer databases: A comprehensive review.

PubMed

Sarode, Gargi S; Sarode, Sachin C; Maniyar, Nikunj; Anand, Rahul; Patil, Shankargouda

2017-11-29

Cancer database is a systematic collection and analysis of information on various human cancers at genomic and molecular level that can be utilized to understand various steps in carcinogenesis and for therapeutic advancement in cancer field. Oral cancer is one of the leading causes of morbidity and mortality all over the world. The current research efforts in this field are aimed at cancer etiology and therapy. Advanced genomic technologies including microarrays, proteomics, transcrpitomics, and gene sequencing development have culminated in generation of extensive data and subjection of several genes and microRNAs that are distinctively expressed and this information is stored in the form of various databases. Extensive data from various resources have brought the need for collaboration and data sharing to make effective use of this new knowledge. The current review provides comprehensive information of various publicly accessible databases that contain information pertinent to oral squamous cell carcinoma (OSCC) and databases designed exclusively for OSCC. The databases discussed in this paper are Protein-Coding Gene Databases and microRNA Databases. This paper also describes gene overlap in various databases, which will help researchers to reduce redundancy and focus on only those genes, which are common to more than one databases. We hope such introduction will promote awareness and facilitate the usage of these resources in the cancer research community, and researchers can explore the molecular mechanisms involved in the development of cancer, which can help in subsequent crafting of therapeutic strategies. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

77 FR 419 - Drawbridge Operation Regulation; St. Johns River, Jacksonville, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-05

... Operation Regulation; St. Johns River, Jacksonville, FL AGENCY: Coast Guard, DHS. ACTION: Notice of... bridge across the St. Johns River, mile 24.9, in Jacksonville, Florida. The regulation is set forth in 33... automated railroad bridge over the St. Johns River in Jacksonville, Florida. This temporary deviation will...

NIH Research Leads to Cervical Cancer Vaccine

MedlinePlus

... Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents For ... Douglas Lowy (left) and John Schiller developed the vaccine to prevent HPV infection in women, the cause ...

76 FR 4940 - John G. Costino, D.O.; Dismissal of Proceeding

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... DEPARTMENT OF JUSTICE Drug Enforcement Administration John G. Costino, D.O.; Dismissal of... to Show Cause to John G. Costino, D.O. (Respondent), of North Wildwood, New Jersey. The Show Cause... Show Cause issued to John G. Costino, D.O., be, and it hereby is, dismissed. Dated: January 18, 2011...

33 CFR 165.721 - Safety Zone: St. Johns River, Jacksonville, FL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: St. Johns River... Zone: St. Johns River, Jacksonville, FL. (a) Location. The following area is established as a safety... barges during the storage, preparation, and launching of fireworks in the St. Johns River between the...

John Sawhill: Academe's Crisis Manager.

ERIC Educational Resources Information Center

Chernow, Ron

1979-01-01

John C. Sawhill became president of New York University (NYU) and balanced its budget in a year. His administration of the university, his personality, NYU's financial situation and the subsequent reforms, fund raising, faculty morale and governance, and efforts to improve the university's academic reputation are discussed. (JMD)

Col John Boyds Innovative DNA

DTIC Science & Technology

2015-09-01

Steve Jobs put it, why do some people seem to “think different”? Why are some people more successful innovators than others? Dyer, Gregersen, and...identifies the five traits of successful innovators and then determines how well John Boyd exem- plified those traits.2 As Apple Computer’s founder

How Do You Motivate Long-Term Behavior Change to Prevent Cancer?

Cancer.gov

John P. Pierce PhD, a professor in the Department of Family and Preventive Medicine at the University of California, San Diego and Director of Population Science at Moores Cancer Center, presented "How Do You Motivate Long-Term Behavior Change to Prevent Cancer?" 

33 CFR 165.722 - Security Zone: St. Johns River, Jacksonville, Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone: St. Johns River....722 Security Zone: St. Johns River, Jacksonville, Florida. (a) Location. The water located within the following area is established as a security zone: beginning at the shoreline of the St. Johns River at the...

Understanding male cancer patients' barriers to participating in cancer rehabilitation.

PubMed

Handberg, C; Lomborg, K; Nielsen, C V; Oliffe, J L; Midtgaard, J

2015-11-01

The aim was to describe male cancer survivors' barriers towards participation in cancer rehabilitation as a means to guiding future targeted men's cancer rehabilitation. Symbolic Interactionism along with the interpretive descriptive methodology guided the study of 35 male cancer survivors representing seven cancer types. Data were generated through a 5-month fieldwork study comprising participant observations, semi-structured individual interviews and informal conversations. The analyses revealed two overarching findings shedding light on male cancer survivors' barriers to rehabilitation: 'Fear of losing control' and 'Striving for normality'. While 'Fear of losing control' signified what the men believed rehabilitation would invoke: 'Reduced manliness', 'Sympathy and dependency' and 'Confrontation with death', 'Striving for normality' was based on what the men believed rehabilitation would hinder: 'Autonomy and purpose', 'Solidarity and fellowship' and 'Forget and move on'. This study of male cancer survivors' and cancer rehabilitation documents how masculine ideals may constitute barriers for participation in rehabilitation and provides insights about why men are underrepresented in rehabilitation. The findings can guide practice to develop research-based rehabilitation approaches focused on preserving control and normality. Further empirical evidence is needed to: (1) explore the conduct of health professionals' towards male cancer patients and (2) address gender inequalities in cancer rehabilitation. © 2015 John Wiley & Sons Ltd.

Survivor identity after colorectal cancer: antecedents, prevalence and outcomes.

PubMed

Chambers, Suzanne K; Baade, Peter; Meng, Xingqiong; Youl, Pip; Aitken, Joanne; Dunn, Jeff

2012-09-01

Cancer survivor identity has become a dominant paradigm in describing people with cancer and in driving the focus of programmes and research in supportive care. This study investigated antecedents of survivor identity adoption and population-based prevalence. A prospective survey of a population-based sample of 1966 (57% response) patients with colorectal cancer assessed socio-demographic variables, health behaviours, optimism, benefit finding, cancer threat appraisal, psychological distress and satisfaction with life at 5 months post-diagnosis as predictors of survivor identity 5 years subsequently. Prevalence of survivor identity at 5 years post-diagnosis and psychological and lifestyle outcomes (n = 786) were later assessed. Fifty-five per cent of people identified as a cancer survivor, 39.4% as a person who had had (or has) cancer, 1.4% as a cancer patient and 1.2% as a cancer victim. People who were older and who reported higher personal growth after diagnosis were more likely to assume a survivor identity at 5 years. At 5 years, survivors had higher benefit finding and better satisfaction with life. Cancer survivors uniquely reported a significant decrease in somatization and acceptance, and increases in satisfaction with life and physical activity over time. For patients with colorectal cancer, the cancer survivor identity is common but not universal 5 years after diagnosis; and may evolve from looking for benefit after cancer through personal growth. People who adopt a cancer survivor identity report more positive adjustment outcomes after cancer and this has implications for the design of clinical and community support interventions. Copyright © 2011 John Wiley & Sons, Ltd. Copyright © 2011 John Wiley & Sons, Ltd.

76 FR 39867 - Russell, John G.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6309-001] Russell, John G.; Notice of Filing Take notice that on June 29, 2011, John G. Russell submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the Federal Power Act, 16...

Press Site Auditorium dedicated to John Holliman

NASA Technical Reports Server (NTRS)

1999-01-01

NASA Administrator Daniel S. Goldin hands Mrs. Dianne Holliman a plaque honoring her late husband, John Holliman, a CNN national correspondent. Standing behind Goldin is Center Director Roy Bridges. At right is Tom Johnson, news group chairman of CNN. A ceremony dedicated the KSC Press Site auditorium as the John Holliman Auditorium to honor the correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

Human radiation studies: Remembering the early years. Oral history of biochemist John Randolph Totter, Ph.D., January 23, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-09-01

This document is a transcript of an interview of Dr. John Randolph Tottler by representatives of the US DOE Office of Human Radiation Experiments. Dr. Tottler was selected for this interview because of his career with the Atomic Energy Commission Division of Biology and Medicine (DBM), particularly as its director from 1967 to 1972. After a short biographical sketch Dr. Tottler discusses his remembrances on a wide range topics including nucleic acid and leukemia research at Oak Ridge, AEC biochemistry training in South America, DBM`s research focus on radiation effects, early leadership of DBM, relations with the US Public Healthmore » Service, controversies on low-level radiation, iodine from fallout, on John Gofman, and Project Plowshare, funding for AEC Research Programs and for international research, testicular irradiation of prisoners in Washington State and Oregon, Plutonium injections, ethics of government radiation research, and opinions of public misperceptions about radiation and cancer.« less

The Research of John Edmond: A Brief History

NASA Astrophysics Data System (ADS)

Boyle, E. A.

2001-12-01

John Edmond left his undergraduate solution chemistry background in damp Scotland for the sunny shores of La Jolla, where Ed Goldberg attempted to interest him in sediment chemistry (his response upon seeing messy marine sediments was not enthusiastic). Charles Keeling also attempted to interest John in CO2 manometry (too many stopcocks to grease). So John evolved into one of those graduate students at Scripps who it was hard to tell from the faculty, and financed by an International Nickel Fellowship and the ONR grant of his nominal thesis supervisor Mel Peterson (who was moving into directorship of the Deep Sea Drilling Project), John parlayed a hot tip from L.G. Sillen on Gran titrations into a thesis on the CO2 system (alkalinity and SCO2) in seawater. He produced fine data coveted by SIO faculty members and set the stage for CO2 system efforts by the GEOSECS program. Perhaps influenced by a summer fellowship at WHOI working on trace elements in Eel Pond (with Derek Spencer), John became interested in oceanic trace metal distributions and collected water samples from the Southern Ocean. This work led to papers on the oceanic Si cycle and a GEOSECS-based study of the relationship between Ra, Ba, and Si. He also became interested in the role of particulate elemental transport in the ocean and river chemistry, and so he set his first batch of graduate students on investigators of oceanic trace metals, marine particle fluxes, and New England river and estuarine chemistry. This line of investigation also extended to studies of African lake chemistry in collaboration with Ray Weiss and Harmon Craig. These studies led John to develop a laboratory with a diverse set of tools for the elemental analysis of freshwater and seawater samples. At the same time, he was talking to heat flow geophysicists who were predicting that hydrothermal springs should be found on the seafloor at mid-ocean ridge crests. So it was no accident when he seized the opportunity to join his old

John Dewey--Philosopher and Educational Reformer

ERIC Educational Resources Information Center

Talebi, Kandan

2015-01-01

John Dewey was an American philosopher and educator, founder of the philosophical movement known as pragmatism, a pioneer in functional psychology, and a leader of the progressive movement in education in the United States.

SSX2-4 expression in early-stage non-small cell lung cancer.

PubMed

Greve, K B V; Pøhl, M; Olsen, K E; Nielsen, O; Ditzel, H J; Gjerstorff, M F

2014-05-01

The expression of cancer/testis antigens SSX2, SSX3, and SSX4 in non-small cell lung cancers (NSCLC) was examined, since they are considered promising targets for cancer immunotherapy due to their immunogenicity and testis-restricted normal tissue expression. We characterized three SSX antibodies and performed immunohistochemical staining of 25 different normal tissues and 143 NSCLCs. The antibodies differed in binding to two distinctive splice variants of SSX2 that exhibited different subcellular staining patterns, suggesting that the two splice variants display different functions. SSX2-4 expression was only detected in 5 of 143 early-stage NSCLCs, which is rare compared to other cancer/testis antigens (e.g. MAGE-A and GAGE). However, further studies are needed to determine whether SSX can be used as a prognostic or predictive biomarker in NSCLC. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

An Interview with John Liontas

ERIC Educational Resources Information Center

Sadeghi, Karim

2017-01-01

John I. Liontas, Ph.D. is an associate professor of foreign languages, English for speakers of other languages (ESOL), and technology in education and second language acquisition (TESLA), and director and faculty of the TESLA doctoral program at the University of South Florida. Dr. Liontas is a distinguished thought leader, author, and…

77 FR 27766 - Jamar, John P.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6870-000] Jamar, John P.; Notice of Filing Take notice that on May 3, 2012, John P. Jamar submitted for filing, an application for... , or call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time...

John B. Watson's Alleged Sex Research: An Appraisal of the Evidence

ERIC Educational Resources Information Center

Benjamin, Ludy T. Jr.; Whitaker, Jodi L.; Ramsey, Russell M.; Zeve, Daniel R.

2007-01-01

In 1974, a story was published about clandestine research done by John B. Watson that was judged to be so reprehensible that it was offered as the real reason he was fired from his faculty position at Johns Hopkins University in 1920, at perhaps the peak of his academic career. Watson's dismissal from Johns Hopkins may have been the most important…

Bayesian lead time estimation for the Johns Hopkins Lung Project data.

PubMed

Jang, Hyejeong; Kim, Seongho; Wu, Dongfeng

2013-09-01

Lung cancer screening using X-rays has been controversial for many years. A major concern is whether lung cancer screening really brings any survival benefits, which depends on effective treatment after early detection. The problem was analyzed from a different point of view and estimates were presented of the projected lead time for participants in a lung cancer screening program using the Johns Hopkins Lung Project (JHLP) data. The newly developed method of lead time estimation was applied where the lifetime T was treated as a random variable rather than a fixed value, resulting in the number of future screenings for a given individual is a random variable. Using the actuarial life table available from the United States Social Security Administration, the lifetime distribution was first obtained, then the lead time distribution was projected using the JHLP data. The data analysis with the JHLP data shows that, for a male heavy smoker with initial screening ages at 50, 60, and 70, the probability of no-early-detection with semiannual screens will be 32.16%, 32.45%, and 33.17%, respectively; while the mean lead time is 1.36, 1.33 and 1.23 years. The probability of no-early-detection increases monotonically when the screening interval increases, and it increases slightly as the initial age increases for the same screening interval. The mean lead time and its standard error decrease when the screening interval increases for all age groups, and both decrease when initial age increases with the same screening interval. The overall mean lead time estimated with a random lifetime T is slightly less than that with a fixed value of T. This result is hoped to be of benefit to improve current screening programs. Copyright © 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

Tribes of Men: John Joseph Mathews and Indian Internationalism

ERIC Educational Resources Information Center

Lutenski, Emily

2012-01-01

In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

Original Mercury Astronauts with Col. John A. (Shorty) Powers

NASA Technical Reports Server (NTRS)

1961-01-01

Photo of the original Mercury Astronauts with Col. John A. (Shorty) Powers seated around a table talking to the news media. From left to right are: L. Gordon Cooper, Donald K. Slayton, John H. Glenn, Jr., Col. Powers, Alan B. Shepard Jr., M. Scott Carpenter, and Walter M. Schirra Jr. Virgil I. Grissom is out of the frame.

Familiar-Strange: Teaching the Scripture as John Would Teach

ERIC Educational Resources Information Center

Ha, Tung-Chiew

2014-01-01

The Gospel of John teaches through telling the story of Jesus in light of the familiar Hebrew faith stories. It is an interpretive task that presents Jesus to his audience and teaches them adequate faith. John the Teacher skillfully uses narrative skills to create the familiar-strange effect in his storytelling. Each story is followed by a…

John Milton's Rainbow: Sonnet XIX.

ERIC Educational Resources Information Center

Scher, Amy

John Milton presented a wide spectrum of materials and ideas illuminating the literary landscape like a rainbow which critics and authors have been discussing for centuries. One example of the multiple layers of meaning in Milton's poems is found in Sonnet XIX, which can be useful for both forensic discussion as well as for composition…

John Milton Oskison and Assimilation

ERIC Educational Resources Information Center

Larre, Lionel

2013-01-01

John Milton Oskison (1874-1947) was a Cherokee writer, journalist, and activist and the author of novels and biographies as well as numerous short stories, essays, and articles about a great variety of subjects. Oskison thought of himself as "an interpreter to the world, of the modern, progressive Indian." The kind of representation Oskison gave…

Breast cancer: The translation of big genomic data to cancer precision medicine.

PubMed

Low, Siew-Kee; Zembutsu, Hitoshi; Nakamura, Yusuke

2018-03-01

Cancer is a complex genetic disease that develops from the accumulation of genomic alterations in which germline variations predispose individuals to cancer and somatic alterations initiate and trigger the progression of cancer. For the past 2 decades, genomic research has advanced remarkably, evolving from single-gene to whole-genome screening by using genome-wide association study and next-generation sequencing that contributes to big genomic data. International collaborative efforts have contributed to curating these data to identify clinically significant alterations that could be used in clinical settings. Focusing on breast cancer, the present review summarizes the identification of genomic alterations with high-throughput screening as well as the use of genomic information in clinical trials that match cancer patients to therapies, which further leads to cancer precision medicine. Furthermore, cancer screening and monitoring were enhanced greatly by the use of liquid biopsies. With the growing data complexity and size, there is much anticipation in exploiting deep machine learning and artificial intelligence to curate integrative "-omics" data to refine the current medical practice to be applied in the near future. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Rep. Delaney Learns about Breast Cancer Research at NCI at Frederick | Poster

Cancer.gov

By Andrea Frydl, Contributing Writer Rep. John Delaney (D-Md., 6th District) visited the NCI Campus at Frederick on October 21 to learn more about the research that scientists at NCI at Frederick are doing on breast cancer. October is Breast Cancer Awareness month.

Validation of surrogate endpoints in cancer clinical trials via principal stratification with an application to a prostate cancer trial.

PubMed

Tanaka, Shiro; Matsuyama, Yutaka; Ohashi, Yasuo

2017-08-30

Increasing attention has been focused on the use and validation of surrogate endpoints in cancer clinical trials. Previous literature on validation of surrogate endpoints are classified into four approaches: the proportion explained approach; the indirect effects approach; the meta-analytic approach; and the principal stratification approach. The mainstream in cancer research has seen the application of a meta-analytic approach. However, VanderWeele (2013) showed that all four of these approaches potentially suffer from the surrogate paradox. It was also shown that, if a principal surrogate satisfies additional criteria called one-sided average causal sufficiency, the surrogate cannot exhibit a surrogate paradox. Here, we propose a method for estimating principal effects under a monotonicity assumption. Specifically, we consider cancer clinical trials which compare a binary surrogate endpoint and a time-to-event clinical endpoint under two naturally ordered treatments (e.g. combined therapy vs. monotherapy). Estimation based on a mean score estimating equation will be implemented by the expectation-maximization algorithm. We will also apply the proposed method as well as other surrogacy criteria to evaluate the surrogacy of prostate-specific antigen using data from a phase III advanced prostate cancer trial, clarifying the complementary roles of both the principal stratification and meta-analytic approaches in the evaluation of surrogate endpoints in cancer. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

67. Historic American Buildings Survey John Oliver Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

67. Historic American Buildings Survey John Oliver Brostrup, Photographer August 12,1936 1:35 P. M. VIEW OF C.C.C. BOYS SCREENING FOR ARTIFACTS. - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

71. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. Historic American Buildings Survey John O. Brostrup, Photographer August 12, 1936 1:30 P. M. VIEW OF C.C.C. BOYS EXCAVATING IN UNIT A. - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

The Art of John Biggers

ERIC Educational Resources Information Center

Coy, Mary

2010-01-01

In their 2005 exhibit of John Biggers' work, the New Orleans Museum of Art described it as being inspired by "African art and culture, the injustices of a segregated United States, the stoic women in his own family, and the heroes of everyday survival." In this article, the author describes how her students reinterpreted Biggers' work.…

YouTube as a source of information on mouth (oral) cancer.

PubMed

Hassona, Y; Taimeh, D; Marahleh, A; Scully, C

2016-04-01

We examined the content of YouTube(™) videos on mouth (oral) cancer and evaluated their usefulness in promoting early detection of oral cancer. A systematic search of YouTube(™) for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral cancer'. Demographics of videos, including type, source, length, and viewers' interaction, were evaluated, and three researchers independently assessed the videos for usefulness in promoting early detection of oral cancer. A total of 188 YouTube(™) videos (152 patient-oriented educational videos and 36 testimonial videos) were analyzed. The overall usefulness score ranged from 0 to 10 (mean = 3.56 ± 2.44). The most useful videos ranked late on the viewing list, and there was no significant correlation between video usefulness and viewing rate, viewers' interaction, and video length. Videos uploaded by individual users were less useful compared with videos uploaded by professional organizations or by healthcare professionals. Healthcare professionals, academic institutions, and professional organizations have a responsibility for improving the content of YouTube(™) about mouth cancer by uploading useful videos, and directing patients to reliable information sources. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

40. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Historic American Buildings Survey John O. Brostrup, Photographer August 13, 1936 1:50 P. M. DETAIL OF SOUTH WALL-CENTRAL ROOM OF BASEMENT-UNIT B-AFTER CHALKING - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

39. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Historic American Buildings Survey John O. Brostrup, Photographer August 13, 1936 1:30 P. M. DETAIL OF SOUTH WALL-CENTRAL ROOM OF BASEMENT-UNIT B-BEFORE CHALKING. - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

47. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Historic American Buildings Survey John O. Brostrup, Photographer August 13, 1936 1:15 P. M. DETAIL OF BASEMENT WINDOW SILL-NORTH WALL, WEST WING-UNIT 'B'. - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

John H Glenn Jr.

NASA Image and Video Library

1962-02-20

Project Mercury astronaut John H. Glenn Jr., enters the Friendship 7 spacecraft during the last part of the countdown on Feb. 20, 1962. At 9:47 a.m. EST, the Atlas launch vehicle lifted the spacecraft into orbit for a three-orbit mission lasting four hours, 55 minutes and 23 seconds. Glenn and his spacecraft were recovered by the destroyer Noa just 21 minutes after landing in the Atlantic near Grand Turk Island, to successfully complete the nation's first manned orbital flight.

Drug delivery strategies for chemoprevention of UVB-induced skin cancer: A review.

PubMed

Bagde, Arvind; Mondal, Arindam; Singh, Mandip

2018-01-01

Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast, and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed toward improvements in terms of delivery modes, therapeutic agents, and site-specificity of therapeutics delivery. The effective chemoprevention activity achieved is based on the efficiency of the delivery system used and the amount of the therapeutic molecule deposited in the skin. In this article, we have discussed different studies performed specifically for the chemoprevention of UVB-induced skin cancer. Ultra-flexible nanocarriers, transethosomes nanocarriers, silica nanoparticles, silver nanoparticles, nanocapsule suspensions, microemulsion, nanoemulsion, and polymeric nanoparticles which have been used so far to deliver the desired drug molecule for preventing the UVB-induced skin cancer. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The molecular basis of breast cancer pathological phenotypes.

PubMed

Heng, Yujing J; Lester, Susan C; Tse, Gary Mk; Factor, Rachel E; Allison, Kimberly H; Collins, Laura C; Chen, Yunn-Yi; Jensen, Kristin C; Johnson, Nicole B; Jeong, Jong Cheol; Punjabi, Rahi; Shin, Sandra J; Singh, Kamaljeet; Krings, Gregor; Eberhard, David A; Tan, Puay Hoon; Korski, Konstanty; Waldman, Frederic M; Gutman, David A; Sanders, Melinda; Reis-Filho, Jorge S; Flanagan, Sydney R; Gendoo, Deena Ma; Chen, Gregory M; Haibe-Kains, Benjamin; Ciriello, Giovanni; Hoadley, Katherine A; Perou, Charles M; Beck, Andrew H

2017-02-01

The histopathological evaluation of morphological features in breast tumours provides prognostic information to guide therapy. Adjunct molecular analyses provide further diagnostic, prognostic and predictive information. However, there is limited knowledge of the molecular basis of morphological phenotypes in invasive breast cancer. This study integrated genomic, transcriptomic and protein data to provide a comprehensive molecular profiling of morphological features in breast cancer. Fifteen pathologists assessed 850 invasive breast cancer cases from The Cancer Genome Atlas (TCGA). Morphological features were significantly associated with genomic alteration, DNA methylation subtype, PAM50 and microRNA subtypes, proliferation scores, gene expression and/or reverse-phase protein assay subtype. Marked nuclear pleomorphism, necrosis, inflammation and a high mitotic count were associated with the basal-like subtype, and had a similar molecular basis. Omics-based signatures were constructed to predict morphological features. The association of morphology transcriptome signatures with overall survival in oestrogen receptor (ER)-positive and ER-negative breast cancer was first assessed by use of the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset; signatures that remained prognostic in the METABRIC multivariate analysis were further evaluated in five additional datasets. The transcriptomic signature of poorly differentiated epithelial tubules was prognostic in ER-positive breast cancer. No signature was prognostic in ER-negative breast cancer. This study provided new insights into the molecular basis of breast cancer morphological phenotypes. The integration of morphological with molecular data has the potential to refine breast cancer classification, predict response to therapy, enhance our understanding of breast cancer biology, and improve clinical management. This work is publicly accessible at www.dx.ai/tcga_breast. Copyright © 2016

Lung Cancer in Women with a Family History of Cancer: The Spanish Female-specific Database WORLD07.

PubMed

Isla, Dolores; Felip, Enriqueta; Viñolas, Nuria; Provencio, Mariano; Majem, Margarita; Artal, Angel; Bover, Isabel; Lianes, Pilar; DE Las Peñas, Ramón; Catot, Silvia; DE Castro, Javier; Blasco, Ana; Terrasa, Josefa; Gonzalez-Larriba, José Luis; Juan, Oscar; Dómine, Manuel; Bernabe, Reyes; Garrido, Pilar

2016-12-01

The WORLD07 project is a female-specific database to prospectively analyze the characteristics of Spanish women with lung cancer. We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer. Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p<0.001) and lung cancer (r=-0.176; p<0.001). Longer median overall survival was observed in women with a family history of cancer and lung cancer. Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Location of John Klein Drill Site

NASA Image and Video Library

2013-03-12

This false-color map shows the area within Gale Crater on Mars, where NASA Curiosity rover landed on Aug. 5, 2012 PDT Aug. 6, 2012 EDT and the location where Curiosity collected its first drilled sample at the John Klein rock.

52. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. Historic American Buildings Survey John O. Brostrup, Photographer August 12, 1936 8:55 A. M. NORTH SIDE OF DUTCH OVEN (GENERAL VIEW) - BASEMENT OF WEST WING OF UNIT B - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

John Day Watershed Restoration Projects, annual report 2003.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Linda

The John Day is the nation's second longest free-flowing river in the contiguous United States and the longest containing entirely unsupplemented runs of anadromous fish. Located in eastern Oregon, the basin drains over 8,000 square miles, Oregon's fourth largest drainage basin, and incorporates portions of eleven counties. Originating in the Strawberry Mountains near Prairie City, the John Day River flows 284 miles in a northwesterly direction, entering the Columbia River approximately four miles upstream of the John Day dam. With wild runs of spring Chinook salmon and summer steelhead, westslope cutthroat, and redband and bull trout, the John Day systemmore » is truly a basin with national significance. The majority of the John Day basin was ceded to the Federal government in 1855 by the Confederated Tribes of the Warm Springs Reservation of Oregon (Tribes). In 1997, the Tribes established an office in the basin to coordinate restoration projects, monitoring, planning and other watershed activities on private and public lands. Once established, the John Day Basin Office (JDBO) formed a partnership with the Grant Soil and Water Conservation District (GSWCD), which contracts the majority of the construction implementation activities for these projects from the JDBO. The GSWCD completes the landowner contact, preliminary planning, engineering design, permitting, construction contracting, and construction implementation phases of most projects. The JDBO completes the planning, grant solicitation/defense, environmental compliance, administrative contracting, monitoring, and reporting portion of the program. Most phases of project planning, implementation, and monitoring are coordinated with the private landowners and basin agencies, such as the Oregon Department of Fish and Wildlife and Oregon Water Resources Department. In 2003, the JDBO and GSWCD proposed continuation of their successful partnership between the two agencies and basin landowners to implement an

Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness.

PubMed

Leung, Thomas Ho-Yin; Tang, Hermit Wai-Man; Siu, Michelle Kwan-Yee; Chan, David Wai; Chan, Karen Kar-Loen; Cheung, Annie Nga-Yin; Ngan, Hextan Yuen-Sheung

2018-02-01

Accumulating evidence indicates that the human papillomavirus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Subpopulations of cells that reside within tumours are responsible for tumour resistance to cancer therapy and recurrence. However, the identity of such cells residing in cervical cancer and their relationship with the HPV-E6 protein have not been identified. Here, we isolated sphere-forming cells, which showed self-renewal ability, from primary cervical tumours. Gene expression profiling revealed that cluster of differentiation (CD) 55 was upregulated in primary cervical cancer sphere cells. Flow-cytometric analysis detected abundant CD55(+) populations among a panel of HPV-positive cervical cancer cell lines, whereas few CD55(+) cells were found in HPV-negative cervical cancer and normal cervical epithelial cell lines. The CD55(+) subpopulation isolated from the C33A cell line showed significant sphere-forming ability and enhanced tumourigenicity, cell migration, and radioresistance. In contrast, the suppression of CD55 in HPV-positive CaSki cells inhibited tumourigenicity both in vitro and in vivo, and sensitized cells to radiation treatment. In addition, ectopic expression of the HPV-E6 protein in HPV-negative cervical cancer cells dramatically enriched the CD55(+) subpopulation. CRISPR/Cas9 knockout of CD55 in an HPV-E6-overexpressing stable clone abolished the tumourigenic effects of the HPV-E6 protein. Taken together, our data suggest that HPV-E6 protein expression enriches the CD55(+) population, which contributes to tumourigenicity and radioresistance in cervical cancer cells. Targeting CD55 via CRISPR/Cas9 may represent a novel avenue for developing new strategies and effective therapies for the treatment of cervical cancer. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John

The Poetry of John Dewey

ERIC Educational Resources Information Center

Williams, Jerry L.

2016-01-01

This essay examines the poetry of John Dewey, 101 poems in total. Characteristic of the rhymed and metered poetry of the period, they show a very human side of Dewey. This analysis argues that many of his poems deal with existential themes--love, finitude, and God, for example. On a deeper level these poems are also show connections to Dewey's…

John James Audubon & the Turkey

ERIC Educational Resources Information Center

Hinshaw, Craig

2012-01-01

In the first half of the 1800s, John James Audubon roamed the wilds of America attempting to draw all the birds in their natural habitat. He published his life-sized paintings in a huge book entitled "Birds of America." Audubon developed a unique system of depicting the birds in natural poses, such as flying. After shooting the bird, he would wire…

John Todd--Numerical Mathematics Pioneer

ERIC Educational Resources Information Center

Albers, Don

2007-01-01

John Todd, now in his mid-90s, began his career as a pure mathematician, but World War II interrupted that. In this interview, he talks about his education, the significant developments in his becoming a numerical analyst, and the journey that concluded at Caltech. Among the interesting stories are how he met his wife-to-be the mathematician Olga…

Press Site Auditorium dedicated to John Holliman

NASA Technical Reports Server (NTRS)

1999-01-01

From left, Center Director Roy Bridges and NASA Administrator Daniel S. Goldin applaud as Jay Holliman, with the help of his mother, Mrs. Dianne Holliman, unveils a plaque honoring his father, the late John Holliman. At right is Tom Johnson, news group chairman of CNN. The occasion was the dedication of the KSC Press Site auditorium as the John Holliman Auditorium to honor the CNN national correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

ASTRONAUT GLENN, JOHN - MERCURY SPACE SUIT

NASA Image and Video Library

1962-02-20

S62-00965 (20 Feb. 1962) --- Astronaut John H. Glenn Jr., finishes suiting up, and prepares for the launch of his Mercury-Atlas 6 (MA-6) spacecraft. The MA-6 ?Friendship 7? mission marks America's first manned Earth-orbiting spaceflight. Photo credit: NASA

Activities commemorating John B. Herrington as first Native American astronaut

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Joyce and James Herrington, parents of John Herrington, accept a gift during a pre-launch Native American ceremony. They are the parents of John Herrington, mission specialist on mission STS-113. Herrington is the first Native American to be going into space.

Senator John Glenn visit to Johnson Space Center (JSC)

NASA Image and Video Library

1995-05-30

Senator John Glenn visit to Johnson Space Center (JSC). Views of Glenn sitting in cockpit of T-38 in Hangar 276 with John Young, George Abbey, David Leestma and Mark Polansky observing (11150). An engineer explains SPIFEX experiment hardware to Abby, Young and Glenn in Bldg 13 (11151, 11153). Glenn talks with astronaut Terrence T. Henricks and employees in Bldg 9C, Virtual reality lab (11152). Lunch in Bldg 17 Flight Crew support division with Dr. Ellen Baker, Robert "Hoot" Gibson and John Glenn (11154). Linda Godwin, Robert Cabana, Abbey, Young, Baker, Gibson and Glenn at lunch (11155). Astronaut Mark Lee shows Glenn and his aide how to use the virtural reality helmets (11156-7). Glenn shakes the hand of Franklin Chang-Diaz with his plasma rocket in the background in the Sonny Carter Training Facility (SCTF) (11158). Glenn in the Manipulator Development Facility (MDF) Remote Manipulator System (RMS) station mock-up in Bldg 9A with Abbey, Young and aide (11159, 11186). Glenn signs a book for Thomas D. Jones as Frederick Sturckow and Linda Godwin look on (11160). Glenn inside visual-vestibular trainer in Bldg 9B (11161). In conference room meeting with astronaut corps in Bldg 4S, Glenn shakes Robert Cabana's hand (11162). John Glenn and John Young pose for a group shot with Bldg 17 Food lab personnel (11163). Glenn thanks the food lab personnel (11164). Glenn visits Bldg 5 Fixed Base (FB) middeck simulator with astronauts Terrence Henricks and Mary Ellen Weber (11165). Glenn with Charles T. Bourland (11166). STS-70 crew Donald Thomas, Terrence Henricks, Mary Ellen Weber, Nancy Currie and Kevin Kregel with Glenn's advisor (11167). STS-70 crew Thomas, Henricks, Weber, Currie and Kregel with John Glenn (11175). Glenn with Thomas, Kregel, Weber, Henricks and trainer (11176-7). David J. Homan assists Glenn's aide with virtual reality goggles (11168) and Glenn (11174). John Young in Bldg 9C equilibrium trainer (11169). Glenn with Carl Walz in flight deck mock-up of MDF in

John F. Fulton, Coccidioidomycosis, and Penicillin

PubMed Central

Tager, Morris

1976-01-01

When the late Dr. John F. Fulton contracted severe pulmonary coccidioidomycosis in January, 1942, a metastatic lesion posed the threat of further progression and fatal dissemination. The possibility that an untested and generally unavailable antibiotic, penicillin, might be of value in Fulton's illness led his physician, Dr. John Bumstead, to appeal directly to Fulton to obtain this antibiotic, but ostensibly for the benefit of another patient succumbing to hemolytic streptococcal infection. While of no value for Fulton, penicillin was highly successful in the treatment of his other patient and soon of a second one with staphylococcal sepsis and pneumonia. This penicillin, administered in March, 1942, was the first clinical trial of penicillin under the control of the Office of Scientific Research and Development. The unique contribution of Dr. Fulton and of his illness to this event is described. ImagesFIG. 1FIG. 2 PMID:793204

33 CFR 165.720 - Safety/Security Zone: St. Johns River, Jacksonville, FL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety/Security Zone: St. Johns... § 165.720 Safety/Security Zone: St. Johns River, Jacksonville, FL. (a) Location. The water and the land..., within 100 yards of the St. Johns River. (3) All waters within 200 yards of any specified military supply...

John Dewey, William Wirt and the Gary Schools Plan: A Centennial Reappraisal

ERIC Educational Resources Information Center

Thorburn, Malcolm

2017-01-01

A century on from the height of John Dewey's educational writings and the reputation of the Gary Schools Plan as a model of progressive education, the paper reappraises two key matters: the relationship between John Dewey and William Wirt, the first superintendent of the Gary Schools in Gary Indiana, and the coherence between John Dewey's…

Oral cancer screening: knowledge is not enough.

PubMed

Tax, C L; Haslam, S Kim; Brillant, Mgs; Doucette, H J; Cameron, J E; Wade, S E

2017-08-01

The purpose of this cross-sectional study was to investigate whether dental hygienists are transferring their knowledge of oral cancer screening into practice. This study also wanted to gain insight into the barriers that might prevent dental hygienists from performing these screenings. A 27-item survey instrument was constructed to study the oral cancer screening practices of licensed dental hygienists in Nova Scotia. A total of 623 practicing dental hygienists received the survey. The response rate was 34% (n = 212) yielding a maximum margin of error of 5.47 at a 95% confidence level. Descriptive statistics were calculated using IBM SPSS Statistics v21 software (Armonk, NY:IBM Corp). Qualitative thematic analysis was performed on any open-ended responses. This study revealed that while dental hygienists perceived themselves as being knowledgeable about oral cancer screening, they were not transferring this knowledge to actual practice. Only a small percentage (13%) of respondents were performing a comprehensive extra-oral examination, and 7% were performing a comprehensive intra-oral examination. The respondents identified several barriers that prevented them from completing a comprehensive oral cancer screening. Early detection of oral cancer reduces mortality rates so there is a professional responsibility to ensure that comprehensive oral cancer screenings are being performed on patients. Dental hygienists may not have the authority in a dental practice to overcome all of the barriers that are preventing them from performing these screenings. Public awareness about oral cancer screenings could increase the demand for screenings and thereby play a role in changing practice norms. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

8. John and James Dobson Carpet Mill, East and West ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. John and James Dobson Carpet Mill, East and West Parcels, site plan, and survey lower left, 1865. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1865, p. 279. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

Charles Darwin and John Herschel

NASA Astrophysics Data System (ADS)

Warner, B.

2009-11-01

The influence of John Herschel on the philosophical thoughts of Charles Darwin, both through the former's book, Natural Philosophy, and through their meeting in 1836 at the Cape of Good Hope, is discussed. With Herschel having himself speculated on evolution just a few months before he met Darwin, it is probable that he stimulated at least the beginnings of the latter's lifelong work on the subject.

Gynecologic cancer screening and communication with health care providers in women with Lynch syndrome.

PubMed

Burton-Chase, A M; Hovick, S R; Sun, C C; Boyd-Rogers, S; Lynch, P M; Lu, K H; Peterson, S K

2014-08-01

We evaluated knowledge of gynecologic cancer screening recommendations, screening behaviors, and communication with providers among women with Lynch syndrome (LS). Women aged ≥25 years who were at risk for LS-associated cancers completed a semi-structured interview and a questionnaire. Of 74 participants (mean age 40 years), 61% knew the appropriate age to begin screening, 75-80% correctly identified the recommended screening frequency, and 84% reported no previous screening endometrial biopsy. Women initiated discussions with their providers about their LS cancer risks, but many used nonspecific terms or relied on family history. Most were not offered high-risk screening options. While many women were aware of risk-appropriate LS screening guidelines, adherence was suboptimal. Improving communication between women and their providers regarding LS-related gynecologic cancer risk and screening options may help improve adherence. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

How doctors communicate the initial diagnosis of cancer matters: cancer disclosure and its relationship with Patients' hope and trust.

PubMed

Cao, Weidan; Qi, Xiaona; Yao, Ting; Han, Xuanye; Feng, Xujing

2017-05-01

The study is to examine the relationships between perceived initial cancer disclosure communication with doctors, levels of hope, and levels of trust in doctors among cancer patients in China. A total number of 192 cancer inpatients in a cancer hospital in China were surveyed. Perceived disclosure strategies, levels of hope, levels of trust in their doctors, as well as the demographic information were obtained from the participants. In addition to age, patients who had higher levels of perceived emotional support from doctors, or higher levels of perceived personalized disclosure from doctors, or higher levels of perceived discussion of multiple treatment plans with doctors were more likely to have higher levels of trust in doctors. In addition to perceived health status, perceived emotional support from doctors significantly predicted participants' levels of hope. That is, patients who had higher higher levels of perceived doctors' emotional support were more likely to have higher levels of hope. Key disclosure person was a marginally significant variable, that is, patients who were mainly disclosed by family members might have higher levels of hope compared with patients who were mainly disclosed by doctors. When communicating with a cancer patient, doctors might not ignore the importance of emotional support during cancer diagnosis communication. Doctors might want to involve family and collaborate with family to find out ways of personalized disclosure. During the communication process, doctors could provide their patients with multiple treatment options and discuss the benefits and side effects of each treatment. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The role of hypoxia in oral cancer and potentially malignant disorders: a review.

PubMed

Kujan, Omar; Shearston, Kate; Farah, Camile S

2017-04-01

Oral and oropharyngeal cancer are major health problems globally with over 500 000 new cases diagnosed annually. Despite the fact that oral cancer is a preventable disease and has the potential for early detection, the overall survival rate remains at around 50%. Most oral cancer cases are preceded by a group of clinical lesions designated 'potentially malignant disorders'. It is difficult to predict if and when these lesions may transform to malignancy, and in turn it is difficult to agree on appropriate management strategies. Understanding underlying molecular pathways would help in predicting the malignant transformation of oral potentially malignant disorders and ultimately identifying effective methods for early detection and prevention of oral cancer. Reprogramming energy metabolism is an emerging hallmark of cancer that is predominantly controlled by hypoxia-induced genes regulating angiogenesis, tumour vascularization, invasion, drug resistance and metastasis. This review aims to highlight the role of hypoxia in oral carcinogenesis and to suggest future research implications in this arena. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Great Lakes Construction/John Robichaud Information Sheet

EPA Pesticide Factsheets

R5 Great Lakes Construction/John Robichaud (the Company) is located in Monroe, Michigan. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Monroe, Michigan.

John Dalton (1766-1844).

PubMed Central

Emery, A E

1988-01-01

There is no doubt that John Dalton ranks among the great names in science, a position which rests on his enunciation of the Atomic Theory. However, his very first scientific paper in 1798 was concerned with his own affliction of colour blindness and was in fact the first clear description of the disorder. This publication stimulated much subsequent research into the pathophysiology and genetics of the condition. His recorded observations on colour blindness are detailed and precise and betoken the approach which was to characterise all his later research in chemistry. Images PMID:3294412

Cancer biology and genomics: translating discoveries, transforming pathology.

PubMed

Ladanyi, Marc; Hogendoorn, Pancras C W

2011-01-01

Advances in our understanding of cancer biology and discoveries emerging from cancer genomics are being translated into real clinical benefits for patients with cancer. The 2011 Journal of Pathology Annual Review Issue provides a snapshot of recent rapid progress on multiple fronts in the war on cancer or, more precisely, the wars on cancers. Indeed, perhaps the most notable recent shift is reflected by the sharp increase in understanding the biology of multiple specific cancers and using these new insights to inform rationally targeted therapies, with often striking successes. These recent developments, as reviewed in this issue, show how the long-term investments in basic cancer research are finally beginning to bear fruit. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Relationship between antidepressant prescription and breast cancer: a population based study in Taiwan.

PubMed

Chen, Vincent Chin-Hung; Liao, Yin-To; Yeh, Dah-Cherng; Tseng, Hsien-Chun; Stewart, Robert; Lee, Charles Tzu-Chi

2016-07-01

To investigate the association between antidepressant prescription and breast cancer. The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant female users who were more than 15 years old during 1999-2005 with at least 10 prescriptions and one year exposure to an antidepressant. These were matched 1:1 by age and residence to non-antidepressant users from the same database to compare the risk of breast cancer. In a model adjusted by age, residence, insurance amount, and depressive disorder, antidepressant prescription was not associated with breast cancer risk. This held true for both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic antidepressants. There was no evidence for an association between antidepressant prescription and the risk of breast cancer. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Fact Book: John Tyler Community College.

ERIC Educational Resources Information Center

Hollins, Carol S.; Smith, Myra Goodman

This factbook summarizes information about the students, staff and faculty, programs and services, and financial and physical resources of John Tyler Community College (JTCC). Section I focuses on JTCC's students, presenting information on student enrollment by sex, race, full-/part-time status, programs, residence; grade distributions; veteran…

Exploring stigma as a barrier to cancer service engagement with breast cancer survivors in Kampala, Uganda.

PubMed

Meacham, Elizabeth; Orem, Jackson; Nakigudde, Gertrude; Zujewski, Jo Anne; Rao, Deepa

2016-10-01

To understand the role of stigma in the delay of cancer service engagement by women with breast cancer in Kampala, Uganda. Women in Sub-Saharan African countries are twice as likely to die from cancer as women in high-income countries, which is largely attributable to late diagnosis. While breast cancer-related stigma has been identified in Sub-Saharan Africa, limited research focuses on how stigma impacts the behavior of breast cancer patients in Uganda. This qualitative study used a grounded theory approach to examine illness narratives from 20 breast cancer survivors in Uganda, gathered through semistructured interviews. Thematic analysis showed that perceived and internalized stigma associated with breast cancer influenced care engagement throughout illness, delaying engagement and inhibiting treatment completion. Women identified key factors for overcoming stigma including acceptance of diagnosis, social support, and understanding of breast cancer. The growing burden of mortality associated with breast cancer in Uganda can be mitigated by improving early detection and treatment engagement through interventions which account for key psychosocial barriers such as stigma. Copyright © 2016 John Wiley & Sons, Ltd.

Reverse of non-small cell lung cancer drug resistance induced by cancer-associated fibroblasts via a paracrine pathway.

PubMed

Zhang, Quanhui; Yang, Junping; Bai, Jie; Ren, Jianzhuang

2018-04-01

The tumor microenvironment orchestrates the sustained growth, metastasis and recurrence of cancer. As an indispensable component of the tumor microenvironment, cancer-associated fibroblasts (CAF) are considered as an essential synthetic machine producing various tumor components, leading to cancer sustained stemness, drug resistance and tumor recurrence. Here, we developed a sustainable primary culture of lung cancer cells fed with lung cancer-associated fibroblasts, resulting in enrichment and acquisition of drug resistance in cancer cells. Moreover, IGF2/AKT/Sox2/ABCB1 signaling activation in cancer cells was observed in the presence of CAF, which induces upregulation of P-glycoprotein expression and the drug resistance of non-small cell lung cancer cells. Our results demonstrated that CAF cells constitute a mechanism for cancer drug resistance. Thus, traditional chemotherapy combined with insulin-like growth factor 2 (IGF2) signaling inhibitor may present an innovative therapeutic strategy for non-small cell lung cancer therapy. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Celebrating the Life and Legacy of Dr. John Hope Franklin

ERIC Educational Resources Information Center

Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

2009-01-01

Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

CRNDE: An important oncogenic long non-coding RNA in human cancers.

PubMed

Zhang, Jiaming; Yin, Minuo; Peng, Gang; Zhao, Yingchao

2018-06-01

Aberrant overexpression of long non-coding RNA CRNDE (Colorectal Neoplasia Differentially Expressed) is confirmed in various human cancers, which is correlated with advanced clinicopathological features and poor prognosis. CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. In this review, we provide an overview of the oncogenic role and potential clinical applications of CRNDE. © 2018 John Wiley & Sons Ltd.

Risk of skin cancer in multiple myeloma patients: a retrospective cohort study.

PubMed

Robinson, Austin A; Wang, James; Vardanyan, Suzie; Madden, Erik K; Hebroni, Frank; Udd, Kyle A; Spektor, Tanya M; Nosrati, Jason D; Kitto, Alex Z; Zahab, Michael; Cheema, Simrin; Fors, Darron H; Norberg, Adam; Diehl, Joseph; Waterman, Gabriel N; Swift, Regina A; Crowley, John; Berenson, James R

2016-11-01

Immunosuppressed patients are known to have an increased incidence of skin cancer. Patients with multiple myeloma (MM) show impaired immune function. In the past, because of poor survival, the incidence of specific secondary primary malignancies such as skin cancer among these patients was difficult to establish. With more effective MM therapies that have emerged in recent years, these patients are living markedly longer, and therefore, it becomes of increasing importance to determine whether their risk of developing other medical problems such as skin cancer is increased. We performed a retrospective cohort study of 205 myeloma patients and 193 age-, race-, and gender-matched control subjects to assess the incidence of skin cancers among patients with MM and determine the specific types of and risk factors for skin cancer. We found that there is an increased occurrence of skin cancer among patients with MM compared to control subjects (26.8% vs. 16.1% in controls; P = 0.009). Among specific types of skin cancer, the proportion of patients with squamous cell carcinoma (SCC) was higher than controls (P = 0.016). In addition to MM diagnosis, older age and Caucasian ethnicity were predictors of skin cancer of any type. Furthermore, older age was also a predictor of SCC. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Oregon § 117.881 John Day River. The draw of the... (Washington State Department of Fisheries and the Fish Commission of Oregon) for the Columbia River Fishery...

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Oregon § 117.881 John Day River. The draw of the... (Washington State Department of Fisheries and the Fish Commission of Oregon) for the Columbia River Fishery...

33 CFR 117.881 - John Day River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Oregon § 117.881 John Day River. The draw of the... (Washington State Department of Fisheries and the Fish Commission of Oregon) for the Columbia River Fishery...

John W. Thoburn: International Humanitarian Award

ERIC Educational Resources Information Center

American Psychologist, 2012

2012-01-01

Presents a short biography of the winner of the American Psychological Association's International Humanitarian Award. The 2012 winner, John W. Thoburn, is an extraordinary psychologist who devotes himself consistently to service to underserved populations, especially in the aftermath of natural or human-induced disasters. He exemplifies a genuine…

Geologic setting of the John Day Country, Grant County, Oregon

USGS Publications Warehouse

Thayer, Thomas P.

1977-01-01

One of the Pacific Northwest's most notable outdoor recreation areas, the "John Day Country" in northeastern Oregon, is named after a native Virginian who was a member of the Astor expedition to the mouth of the Columbia River in 1812. There is little factual information about John Day except that he was born in Culpeper County, Virginia, about 1770. It is known also that in 1810 this tall pioneer "with an elastic step as if he trod on springs" joined John Jacob Astor's overland expedition under Wilson Price Hunt to establish a vast fur-gathering network in the Western States based on a major trading post at the mouth of the Columbia River.

11. John and James Dobson Carpet Mill, East and West ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-lower left, and survey-right, 1877. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1877, pp. 1095-1096. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

13. John and James Dobson Carpet Mill, East and West ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. John and James Dobson Carpet Mill, East and West parcels, site plan-upper left, elevation-upper right, and survey-below, 1885. Hexamer, Ernest and Son. Hexamer General Surveys, 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1885, pp. 1890-1891. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

9. John and James Dobson Carpet Mill, portion of West ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. John and James Dobson Carpet Mill, portion of West parcel, site plan-left, elevation-upper right, and survey-lower right, 1873. Hexamer, Ernest and Son. Hexamer General Surveys 1867-1895, Philadelphia, Pennsylvania: E. Hexamer and Son, 1873, pp. 670-671. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

Englerin A Delivers One-Two Punch to Kidney Cancer Cells | Center for Cancer Research

Cancer.gov

While overall cancer death rates continue to decline in the U.S., mortality rates for certain cancer sites, including the kidney, are on the rise. New treatments are needed to reverse this trend and one potentially rich source is natural products, compounds derived from living organisms. John Beutler, Ph.D., and his colleagues, in CCR’s Molecular Targets Laboratory located at the NCI campus in Frederick, Maryland, identified englerin A from an extract of the African plant Phyllanthus engleri that was particularly toxic to kidney cancer cells. To further investigate the activity of englerin A, the Beutler group teamed up with researchers led by Marston Linehan, M.D., and Len Neckers, Ph.D., in CCR’s Urologic Oncology Branch.

75 FR 27359 - Meeting Notice for the John Day/Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

...] Meeting Notice for the John Day/Snake Resource Advisory Council AGENCY: Bureau of Land Management, Interior. ACTION: Meeting Notice for the John Day/Snake Resource Advisory Council. SUMMARY: Pursuant to the... Interior, Bureau of Land Management (BLM) John Day-Snake Resource Advisory Council (JDSRAC) will meet as...

75 FR 37461 - Notice of Public Meeting, John Day/Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

...] Notice of Public Meeting, John Day/Snake Resource Advisory Council AGENCY: Bureau of Land Management, Interior. ACTION: Meeting notice for the John Day/Snake Resource Advisory Council. SUMMARY: Pursuant to the... Interior, Bureau of Land Management (BLM) John Day-Snake Resource Advisory Council (JDSRAC) will meet as...

Speaking Personally--With John "Pathfinder" Lester

ERIC Educational Resources Information Center

Beaubois, Terry

2013-01-01

John Lester is currently the chief learning officer at ReactionGrid, a software company developing 3-D simulations and multiuser virtual world platforms. Lester's background includes working with Linden Lab on Second Life's education activities and neuroscience research. His primary focus is on collaborative learning and instructional…

Astronaut John Glenn tests balance mechanism performance

NASA Image and Video Library

1962-02-01

S64-14849 (1962) --- Astronaut John H. Glenn Jr.'s balance mechanism (semi-circular-canals) is tested by running cool water into his ear and measuring effect on eye motions (nystagmus). Photo credit: NASA

Astronaut John Glenn - Blood Draw - Training - Cape

NASA Image and Video Library

1961-07-05

S61-02579 (1961) --- Astronaut nurse Delores B. O'Hara, R.N., in the Aeromedical Laboratory at Cape Canaveral, Florida, takes a blood sample from Mercury astronaut John H. Glenn Jr. Photo credit: NASA

Cancer immunotherapy-targeted glypican-3 or neoantigens.

PubMed

Shimizu, Yasuhiro; Suzuki, Toshihiro; Yoshikawa, Toshiaki; Tsuchiya, Nobuhiro; Sawada, Yu; Endo, Itaru; Nakatsura, Tetsuya

2018-03-01

Immune checkpoint inhibitors have ushered in a new era in cancer therapy, although other therapies or combinations thereof are still needed for many patients for whom these drugs are ineffective. In this light, we have identified glypican-3 an HLA-24, HLA-A2 restriction peptide with extreme cancer specificity. In this paper, we summarize results from a number of related clinical trials showing that glypican-3 peptide vaccines induce specific CTLs in most patients (UMIN Clinical Trials Registry: UMIN000001395, UMIN000005093, UMIN000002614, UMN000003696, and UMIN000006357). We also describe the current state of personalized cancer immunotherapy based on neoantigens, and assess, based on our own research and experience, the potential of such therapy to elicit cancer regression. Finally, we discuss the future direction of cancer immunotherapy. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

LEAVING PAD - ASTRONAUT JOHN W. YOUNG - TRAINING

NASA Image and Video Library

1965-03-19

S65-20636 (1965) --- Astronauts John W. Young (left), pilot, and Virgil I. Grissom, command pilot, for the Gemini-Titan 3 flight, are shown leaving the launch pad after simulations in the Gemini-3 spacecraft.

From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis.

PubMed

Strock, Stephen B; Alder, Jonathan K; Kass, Daniel J

2018-04-01

Patients with idiopathic pulmonary fibrosis have a significantly increased risk for the development of lung cancer. The morbidity and mortality of this disease combination are substantial, and, unfortunately, there are currently few data to help guide clinicians in its diagnosis and treatment. In a recent issue of this journal, Hwang et al presented one of the first studies to evaluate lung cancer in patients with idiopathic pulmonary fibrosis at the molecular level. They demonstrate variants in regulators of the cell cycle, which are known to be important in malignant transformation and may also be important in the pathogenesis of idiopathic pulmonary fibrosis. Further understanding of the pathogenic overlap between lung cancer and idiopathic pulmonary fibrosis could help point the direction to specific diagnostic modalities and targeted treatment of both conditions in the future. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

John Furlong and the "University Project"

ERIC Educational Resources Information Center

Watson, David

2014-01-01

Like many senior teacher-educators and educational researchers, John Furlong has faced in several directions throughout his career, sometimes simultaneously. He has clearly not lost his enthusiasm for what happens in the classroom: he strongly appreciates those magical moments which can happen at any time, and which keep teachers going. He loves…

We, John Dewey's Audience of Today

ERIC Educational Resources Information Center

da Cunha, Marcus Vinicius

2016-01-01

This article suggests that John Dewey's "Democracy and Education" does not describe education in an existing society, but it conveys a utopia, in the sense coined by Mannheim: utopian thought aims at instigating actions towards the transformation of reality, intending to attain a better world in the future. Today's readers of Dewey (his…

John Dewey on Philosophy and Childhood

ERIC Educational Resources Information Center

Gregory, Maughn; Granger, David

2012-01-01

John Dewey was not a philosopher of education in the now-traditional sense of a doctor of philosophy who examines educational ends, means, and controversies through the disciplinary lenses of epistemology, ethics, and political theory, or of agenda-driven schools such as existentialism, feminism, and critical theory. Rather, Dewey was both an…

The History of Heart Surgery at The Johns Hopkins Hospital.

PubMed

Patel, Nishant D; Alejo, Diane E; Cameron, Duke E

2015-01-01

Johns Hopkins has made many lasting contributions to cardiac surgery, including the discovery of heparin and the Blalock-Taussig Shunt, which represents the dawn of modern cardiac surgery. Equally important, Johns Hopkins has trained some of the world's leaders in academic cardiac surgery, and is committed to training the future leaders in our specialty. Copyright © 2015. Published by Elsevier Inc.

John Glenn Biomedical Engineering Consortium

NASA Technical Reports Server (NTRS)

Nall, Marsha

2004-01-01

The John Glenn Biomedical Engineering Consortium is an inter-institutional research and technology development, beginning with ten projects in FY02 that are aimed at applying GRC expertise in fluid physics and sensor development with local biomedical expertise to mitigate the risks of space flight on the health, safety, and performance of astronauts. It is anticipated that several new technologies will be developed that are applicable to both medical needs in space and on earth.

What do people fear about cancer? A systematic review and meta-synthesis of cancer fears in the general population.

PubMed

Vrinten, Charlotte; McGregor, Lesley M; Heinrich, Małgorzata; von Wagner, Christian; Waller, Jo; Wardle, Jane; Black, Georgia B

2017-08-01

Cancer has long inspired fear, but the effect of fear is not well understood; it seems both to facilitate and to deter early diagnosis behaviours. To elucidate fear's behavioural effects, we systematically reviewed and synthesised qualitative literature to explore what people fear about cancer. We searched Medline, Embase, PsycInfo, Web of Science, AnthroSource, and Anthrobase for studies on cancer fear in breast, cervical, and colorectal cancer screening and analysed 102 studies from 26 countries using thematic synthesis. Fears of cancer emanated from a core view of cancer as a vicious, unpredictable, and indestructible enemy, evoking fears about its proximity, the (lack of) strategies to keep it at bay, the personal and social implications of succumbing, and fear of dying from cancer. This view of cancer as 'an enemy' reprises the media's 'war on cancer' theme and may affect the acceptance of cancer early detection and prevention messages, since cancer's characteristics influenced whether 'fight' or 'flight' was considered appropriate. © 2016 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd.

DNA replication stress and cancer chemotherapy.

PubMed

Kitao, Hiroyuki; Iimori, Makoto; Kataoka, Yuki; Wakasa, Takeshi; Tokunaga, Eriko; Saeki, Hiroshi; Oki, Eiji; Maehara, Yoshihiko

2018-02-01

DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

The financial impact of head and neck cancer caregiving: a qualitative study.

PubMed

Balfe, Myles; Butow, Phyllis; O'Sullivan, Eleanor; Gooberman-Hill, Rachael; Timmons, Aileen; Sharp, Linda

2016-12-01

There is a lack of research on the financial impacts that head and neck cancer has on caregivers. To explore the overall financial impact of head and neck cancer on caregivers; to describe the factors that mitigate this impact. Interviews with 31 caregivers (mean time caring: 5.7 years). Head and neck cancer had a considerable financial impact on caregivers. It resulted in out of pocket costs and caregivers and/or their relative/friend with cancer often became under- or un-employed. Caregivers with large debts or ongoing expenses appeared to be particularly vulnerable to cancer-related financial pressures. Finance related psychological stress was prevalent, although some caregivers hid their psychological difficulties from other people. Factors which help caregivers to mitigate financial distress included having private health insurance and being able to access to medical and/or social welfare benefits. Head and neck cancer can cause caregivers substantial financial and psychological distress. Distress may be mitigated by providing caregivers and their households with access to welfare benefits. Health professionals should be aware that head and neck cancer can have short and long-term financial consequences for caregivers and their families. Health professionals should refer patients and their caregivers to medical social workers who can help them with their financial issues. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

KENNEDY, PRESIDENT JOHN F. - MSC VISIT

NASA Image and Video Library

1962-09-11

S62-03991 (11 September 1962) --- Just before the arrival of President John F. Kennedy at the J. P. Cornelius grade school, on Westover, turned out for a look at the Chief Executive in person. Wearing sun hats they made themselves, 700 children lined the roadway opposite the side entrance to the Rich Building.

School-based brief psycho-educational intervention to raise adolescent cancer awareness and address barriers to medical help-seeking about cancer: a cluster randomised controlled trial.

PubMed

Hubbard, Gill; Stoddart, Iona; Forbat, Liz; Neal, Richard D; O'Carroll, Ronan E; Haw, Sally; Rauchhaus, Petra; Kyle, Richard G

2016-07-01

Raising cancer awareness and addressing barriers to help-seeking may improve early diagnosis. The aim was to assess whether a psycho-educational intervention increased adolescents' cancer awareness and addressed help-seeking barriers. This was a cluster randomised controlled trial involving 2173 adolescents in 20 schools. The intervention was a 50-min presentation delivered by a member of Teenage Cancer Trust's (UK charity) education team. Schools were stratified by deprivation and roll size and randomly allocated to intervention/control conditions within these strata. Outcome measures were the number of cancer warning signs and cancer risk factors recognised, help-seeking barriers endorsed and cancer communication. Communication self-efficacy and intervention fidelity were also assessed. Regression models showed significant differences in the number of cancer warning signs and risk factors recognised between intervention and control groups. In intervention schools, the greatest increases in recognition of cancer warning signs at 6-month follow-up were for unexplained weight loss (from 44.2% to 62.0%) and change in the appearance of a mole (from 46.3% to 70.7%), up by 17.8% and 24.4%, respectively. Greatest increases in recognition of cancer risk factors were for getting sunburnt more than once as a child (from 41.0% to 57.6%) and being overweight (from 42.7% to 55.5%), up by 16.6% and 12.8%, respectively. Regression models showed that adolescents in intervention schools were 2.7 times more likely to discuss cancer at 2-week follow-up compared with the control group. No differences in endorsement of barriers to help-seeking were observed. School-based brief psycho-educational interventions are easy to deliver, require little resource and improve cancer awareness. © 2015 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd. © 2015 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd.

Corporate Perspective: An Interview with John Sculley.

ERIC Educational Resources Information Center

Temares, M. Lewis

1989-01-01

John Sculley, the chairman of the board of Apple Computer, Inc., discusses information technology management, management strategies, network management, the Chief Information Officer, strategic planning, back-to-the-future planning, business and university joint ventures, and security issues. (MLW)

Speaking Personally--With John Seely Brown

ERIC Educational Resources Information Center

American Journal of Distance Education, 2008

2008-01-01

This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

Jean Piaget's Debt to John Dewey

ERIC Educational Resources Information Center

Tanner, Daniel

2016-01-01

Jean Piaget became a veritable institution unto himself in education and psychology, largely as the result of his developmental-stage theory advanced over the second quarter of the twentieth century. Not until Piaget was 73 did he make mention of John Dewey's work at Dewey's laboratory school, founded in 1894 at the University of Chicago. But here…

John Hull and the Money Culture

ERIC Educational Resources Information Center

Attfield, David

2008-01-01

John Hull's recent educational writings have included several on what he calls the "money culture". This is analysed and criticised in this article. Hull offers a Marxist and a neo-Marxist account of the role of money in western societies utilising the labour theory of value, false consciousness and the materialist interpretation of history. It is…

John Langstaff: Community Musician and Reveler

ERIC Educational Resources Information Center

Bartolome, Sarah J.; Campbell, Patricia Shehan

2009-01-01

John Langstaff fits within a select group of pathfinders in American music education who have shaped the profession's service to schools and society with special attention to the traditional musical expressions of American folk. His life and works are worthy of study for the contributions he made as a singer who modelled the nuances of traditional…

Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.

PubMed

Abugattas, J; Llacuachaqui, M; Allende, Y Sullcahuaman; Velásquez, A Arias; Velarde, R; Cotrina, J; Garcés, M; León, M; Calderón, G; de la Cruz, M; Mora, P; Royer, R; Herzog, J; Weitzel, J N; Narod, S A

2015-10-01

The prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association.

PubMed

Atanasova, K R; Yilmaz, O

2014-04-01

The past decades of biomedical research have yielded massive evidence for the contribution of the microbiome in the development of a variety of chronic human diseases. There is emerging evidence that Porphyromonas gingivalis, a well-adapted opportunistic pathogen of the oral mucosa and prominent constituent of oral biofilms, best known for its involvement in periodontitis, may be an important mediator in the development of a number of multifactorial and seemingly unrelated chronic diseases, such as rheumatoid arthritis and orodigestive cancers. Orodigestive cancers represent a large proportion of the total malignancies worldwide, and include cancers of the oral cavity, gastrointestinal tract and pancreas. For prevention and/or enhanced prognosis of these diseases, a good understanding of the pathophysiological mechanisms and the interaction between P. gingivalis and host is much needed. With this review, we introduce the currently accumulated knowledge on P. gingivalis's plausible association with cancer as a risk modifier, and present the putative cancer-promoting cellular and molecular mechanisms that this organism may influence in the oral mucosa. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The role of acculturation in life satisfaction among Hispanic cancer survivors: results of the American Cancer Society's study of cancer survivors.

PubMed

Stephens, Cristina; Stein, Kevin; Landrine, Hope

2010-04-01

We sought to identify the role of acculturation in the life satisfaction of Hispanic cancer survivors. We compared life satisfaction among the high- vs low-acculturated Hispanics who participated in a national, cross-sectional study of quality of life among cancer survivors. Despite fewer socio-economic resources, low-acculturated Hispanic survivors had higher life satisfaction (Beta=5.08, p<0.05). This relationship was mediated by higher levels of social support and spirituality found among low-acculturated survivors, with spirituality being the strongest predictor (Beta=0.379, p<0.001). Acculturation may provide opportunities for improved socio-economic status often necessary for adequate functioning in the host culture. However, it may also result in a departure from traditional cultural values, which in turn may negatively impact life satisfaction during cancer survivorship. Copyright 2009 John Wiley & Sons, Ltd.

John Rogers: "Checkers Up at the Farm."

ERIC Educational Resources Information Center

Zeller, Terry

1987-01-01

Based on John Rogers' 1887 painted plaster sculpture called "Checkers Up at the Farm," this lesson seeks to introduce primary-level students to the idea of sculpture in the round and how sculpture can communicate ideas, emotions, and values. (JDH)

John Glenn Receives Presidential Medal of Freedom

NASA Image and Video Library

2012-05-29

President Barack Obama presents former United States Marine Corps pilot, astronaut, and United States Senator John Glenn with a Medal of Freedom, Tuesday, May 29, 2012, during a ceremony at the White House in Washington. Photo Credit: (NASA/Bill Ingalls)

Inequalities in reported cancer patient experience by socio-demographic characteristic and cancer site: evidence from respondents to the English Cancer Patient Experience Survey.

PubMed

Saunders, C L; Abel, G A; Lyratzopoulos, G

2015-01-01

Patient experience is a critical dimension of cancer care quality. Understanding variation in experience among patients with different cancers and characteristics is an important first step for designing targeted improvement interventions. We analysed data from the 2011/2012 English Cancer Patient Experience Survey (n = 69,086) using logistic regression to explore inequalities in care experience across 64 survey questions. We additionally calculated a summary measure of variation in patient experience by cancer, and explored inequalities between patients with cancers treated by the same specialist teams. We found that younger and very old, ethnic minority patients and women consistently reported worse experiences across questions. Patients with small intestine/rarer lower gastrointestinal, multiple myeloma and hepatobiliary cancers were most likely to report negative experiences whereas patients with breast, melanoma and testicular cancer were least likely (top-to-bottom odds ratio = 1.91, P < 0.0001). There were also inequalities in experience among patients with cancers treated by the same specialty for five of nine services (P < 0.0001). Specifically, patients with ovarian, multiple myeloma, anal, hepatobiliary and renal cancer reported notably worse experiences than patients with other gynaecological, haematological, gastrointestinal and urological malignancies respectively. Initiatives to improve cancer patient experience across oncology services may be suitably targeted on patients at higher risk of poorer experience. © 2014 The Authors. European Journal of Cancer Care published by John Wiley & Sons Ltd.

Weight fluctuation during adulthood and weight gain since breast cancer diagnosis predict multiple dimensions of body image among rural breast cancer survivors.

PubMed

Fazzino, Tera L; Hunter, Rebecca Clausius; Sporn, Nora; Christifano, Danielle N; Befort, Christie A

2017-03-01

Obesity and weight gain after breast cancer treatment are common among survivors, yet the relationship between weight and body image has received little attention. The purpose of the current study was to examine the relationship between current body mass index, weight gain since diagnosis, and largest weight fluctuation in adulthood with six dimensions of body image among overweight/obese breast cancer survivors. The current study used data obtained from a weight control trial with 210 rural overweight/obese breast cancer survivors. Using data collected at baseline, multiple regression models were constructed to examine the relative association of the three weight variables with breast cancer-specific dimensions of body image while controlling for demographic characteristics and cancer treatment-related variables. Largest weight fluctuation in adulthood significantly predicted overall body image (p = 0.01) and was associated with the three socially oriented dimensions of body image: social activity restriction, embarrassment about appearance, and sexuality (all ps = 0.01). Weight gain since diagnosis approached statistical significance in predicting overall body image (p = 0.05) and was associated with embarrassment about appearance (p = 0.03). Current body mass index was not significantly associated with overall body image when controlling for the other weight variables (p = 0.07) and was negatively associated with social activity restriction (p = 0.01) and sexuality (p = 0.01). Obese breast cancer survivors with a history of a large weight fluctuation in adulthood may be prone to poorer breast cancer-specific body image several years after treatment. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy

DTIC Science & Technology

2016-09-01

the risk of cancer (e.g., gastritis-associated stomach cancer , colitis-associated gastric cancer , and hepatitis-associated liver cancer ), its effect...Grade Prostate Cancer and Recurrence after Prostatectomy PRINCIPAL INVESTIGATOR: Elizabeth A. Platz RECIPIENT: Johns Hopkins University Baltimore, MD...Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after 5b. GRANT NUMBER PC110754

John B. Watson's Legacy: Learning and Environment.

ERIC Educational Resources Information Center

Horowitz, Frances Degen

1992-01-01

Evaluates John B. Watson's contributions to developmental psychology. Watson's insistence on objective methodology in psychology retains its influence, but his extreme environmentalism has been rejected. His concern with the principles of learning is reflected in the work of Hull and Skinner. (BC)

John Glenn Receives Presidential Medal of Freedom

NASA Image and Video Library

2012-05-29

President Barack Obama congratulates former United States Marine Corps pilot, astronaut, and United States Senator John Glenn after presenting him with a Medal of Freedom, Tuesday, May 29, 2012, during a ceremony at the White House in Washington. Photo Credit: (NASA/Bill Ingalls)

John Dewey--Problem Solving and History Teaching

ERIC Educational Resources Information Center

Martorella, Peter H.

1978-01-01

Presents a model for introducing inquiry and problem-solving into middle grade history classes. It is based on an educational approach suggested by John Dewey. The author uses the model to explore two seemingly contradictory statements by Abraham Lincoln about slavery. (AV)

James John Harpell: An Adult Education Pioneer.

ERIC Educational Resources Information Center

Quarter, Jack

2000-01-01

In early 20th-century Canada, James John Harpell began correspondence courses and study clubs and was instrumental in the cooperatives movement. He used small businesses to promote social and educational innovations and was an advocate for self-study and lifelong learning. (SK)

X-Box Binding Protein-1 in Breast Cancer

DTIC Science & Technology

2005-08-01

analysis of gene expression (SAGE) as previously described (13), using the "SAGE" software (Dr. Kinzler, Johns Hopkins University). Most genes...rationale for endocrine therapy in breast cancer. Best Pract. Res. Clin. Endocrinol. Metabol. 18, 1–32. Molinari, A. M., Bontempo, P., Schiavone , E. M

Improving outcomes in cancer diagnosis, prevention and control: barriers, facilitators and the need for health literacy in Ibadan Nigeria.

PubMed

Adedimeji, Adebola A; Lounsbury, David; Popoola, Oluwafemi; Asuzu, Chioma; Lawal, Akinmayowa; Oladoyin, V; Crifase, Cassandra; Agalliu, Ilir; Shankar, Viswanathan; Adebiyi, Akindele

2017-10-01

Cancers constitute a significant public health problem in Nigeria. Breast, cervix and prostate cancers are leading causes of cancer-related deaths. Changing diets, lifestyles, HIV/AIDS and macro-structural factors contribute to cancer morbidity and mortality. Poor health information linking cancer risk to individual behaviors, environmental pollutants and structural barriers undermine prevention/control efforts. Studies suggest increasing health literacy and empowering individuals to take preventive action will improve outcomes and mitigate impact on a weak health system. We obtained qualitative data from 80 men, women, and young adults in 11 focus groups to assess beliefs, risk-perceptions, preventive behaviors and perceptions of barriers and facilitators to cancer control in Ibadan, Nigeria and conducted thematic analysis. Participants demonstrated awareness of cancers and mentioned several risk factors related to individual behaviors and the environment. Nonetheless, myths and misconceptions as well as micro, meso and macro level barriers impede prevention and control efforts. Developing and implementing comprehensive context-relevant health literacy interventions in community settings are urgently needed.Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The letters of John Dastin.

PubMed

Thiesen, Wilfred

2008-07-01

John Dastin, a noted alchemist who lived ca. 1300, followed the lead of many of his contemporaries and predecessors in using letters to propagate his views on alchemy. This article identifies a number of letters that Dastin wrote, and includes one text addressed to a cardinal of the city of Naples. This letter is virtually a copy of a work by Arnold of Villanova. I believe that other works ascribed to Dastin will also show a great dependence on Arnold's works.

Adjunctive traditional Chinese medicine therapy improves survival of liver cancer patients.

PubMed

Liao, Yueh-Hsiang; Lin, Cheng-Chieh; Lai, Hsueh-Chou; Chiang, Jen-Huai; Lin, Jaung-Geng; Li, Tsai-Chung

2015-12-01

Traditional Chinese medicine (TCM) is an alternative treatment for cancer with its effect by stimulating host immune response for cytotoxic activity against liver cancer. No studies evaluated TCM treatment on survival of liver cancer patients. This study determined whether the combination of TCM and conventional cancer treatment affects the survival of liver cancer patients. A retrospective cohort study was conducted in 127 237 newly diagnosed liver cancer patients from 2000 to 2009 in the National Health Insurance Program database. Among these patients, 30 992 (24.36%) used TCM for liver cancer care. All patients were followed up until 2011. The mean follow-up was 5.67 years (SD 1.47) for TCM users and 5.49 years (SD 3.64) for non-TCM users. Compared with patients without TCM use, patients with TCM use were significantly associated with a decreased risk of death [hazard ratio (HR) = 0.65, 95% confidence interval (CI) = 0.64-0.66] with multivariate adjustment. A similar significant protective effect of TCM use across various subgroups of chronic liver diseases was also observed. Jia Wei Xiao Yao San (HR = 0.89, 95% CI = 0.81-0.96) and Chai Hu Shu Gan Tang (HR = 0.86, 95% CI = 0.78-0.95) were the most effective TCM agents that improved survival. This cohort study provided information that adjunctive therapy with TCM may improve the survival in liver cancer patients. Further studies are needed to confirm the potential role of TCM in HCC. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

M2-F3 with test pilot John A. Manke

NASA Image and Video Library

1972-12-20

NASA research pilot John A. Manke is seen here in front of the M2-F3 Lifting Body. Manke was hired by NASA on May 25, 1962, as a flight research engineer. He was later assigned to the pilot's office and flew various support aircraft including the F-104, F5D, F-111 and C-47. After leaving the Marine Corps in 1960, Manke worked for Honeywell Corporation as a test engineer for two years before coming to NASA. He was project pilot on the X-24B and also flew the HL-10, M2-F3, and X-24A lifting bodies. John made the first supersonic flight of a lifting body and the first landing of a lifting body on a hard surface runway. Manke served as Director of the Flight Operations and Support Directorate at the Dryden Flight Research Center prior to its integration with Ames Research Center in October 1981. After this date John was named to head the joint Ames-Dryden Directorate of Flight Operations. He also served as site manager of the NASA Ames-Dryden Flight Research Facility. John is a member of the Society of Experimental Test Pilots. He retired on April 27, 1984.

Are cancer cells really softer than normal cells?

PubMed

Alibert, Charlotte; Goud, Bruno; Manneville, Jean-Baptiste

2017-05-01

Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid than its surrounding environment. Paradoxically, individual cancer cells appear to be softer than their healthy counterparts. In this review, we first list the physiological reasons indicating that cancer cells may be more deformable than normal cells. Next, we describe the biophysical tools that have been developed in recent years to characterise and model cancer cell mechanics. By reviewing the experimental studies that compared the mechanics of individual normal and cancer cells, we argue that cancer cells can indeed be considered as softer than normal cells. We then focus on the intracellular elements that could be responsible for the softening of cancer cells. Finally, we ask whether the mechanical differences between normal and cancer cells can be used as diagnostic or prognostic markers of cancer progression. © 2017 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

Astronaut John Glenn Enters Friendship 7

NASA Technical Reports Server (NTRS)

1962-01-01

Astronaut John Glenn enters the Mercury spacecraft, Friendship 7, prior to the launch of MA-6 on February 20, 1961 and became the first American who orbited the Earth. The MA-6 mission was the first manned orbital flight boosted by the Mercury-Atlas vehicle, a modified Atlas ICBM (Intercontinental Ballistic Missile), lasted for five hours, and orbited the Earth three times.

John Dewey's Visits to Hawai'i

ERIC Educational Resources Information Center

McEwan, Hunter

2015-01-01

John Dewey visited Hawai'i on three separate occasions. Of all three trips, by far the most important, as far as Dewey's influence on education in Hawai'i is concerned, was in 1899 when he came with his wife, Alice Chipman Dewey, to help launch the University Extension program in Honolulu. The Deweys' second trip was a very brief one--twenty years…

Seminal Plasma Proteins as Androgen Receptor Corregulators Promote Prostate Cancer Growth

DTIC Science & Technology

2015-10-01

functional analyses of semenogelins in pathological conditions have been reported and their roles in prostate cancer outgrowth remain uncertain. In...1Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Department of Pathology and Laboratory... pathological conditions have been reported and their roles in prostate cancer growth remain uncertain. In the current study, we aim to determine the

Racial Discrimination, John Henryism, and Depression Among African Americans

PubMed Central

Hudson, Darrell L.; Neighbors, Harold W.; Geronimus, Arline T.; Jackson, James S.

2016-01-01

Evidence from previous studies indicates that racial discrimination is significantly associated with depression and that African Americans with higher levels of socioeconomic status (SES) report greater exposure to racial discrimination compared to those with lower SES levels. Coping strategies could alter the relationship between racial discrimination and depression among African Americans. This study first examined whether greater levels of SES were associated with increased reports of racial discrimination and ratings of John Henryism, a measure of high-effort coping, among African Americans. Second, we examined whether high-effort coping moderated the relationship between racial discrimination and depression. Data were drawn from the National Survey of American Life Reinterview (n = 2,137). Analyses indicated that greater levels of education were positively associated with racial discrimination (p < .001) and increased levels of racial discrimination were positively related to depression (p < .001), controlling for all sociodemographic factors. Greater levels of John Henryism were associated with increased odds of depression but there was no evidence to suggest that the relationship between discrimination and depression was altered by the effects of John Henryism. PMID:27529626

1. John C. Garner, Jr., Photographer 1967 PRINCIPAL (NORTH) SIDE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. John C. Garner, Jr., Photographer 1967 PRINCIPAL (NORTH) SIDE, FROM NORTHWEST. THE RIGHT END OF THE BLOCK IS THE E.S. WOOD BUILDING; THE BUILDING WITH A FIRE ESCAPE IS THE ROSENFIELD BUILDING; THE T.W. HOUSE BUILDING IS TO THE LEFT OF THE PRECEDING BUILDING; JOHN BERLOCHER BUILDING IS AT THE LEFT END OF THE BLOCK. - Strand Historic District, Wood-Rosenfield-House-Berlocher Buildings, 2213-2223 Strand, Galveston, Galveston County, TX

High Resolution Anatomic and Elastographic Transrectal Ultrasound for Improved Diagnosis of Prostate Cancer

DTIC Science & Technology

2007-02-01

Elastographic Transrectal Ultrasound for Improved Diagnosis of Prostate Cancer PRINCIPAL INVESTIGATOR: John A. Hossack, Ph.D...Resolution Anatomic and Elastographic Transrectal Ultrasound for Improved 5a. CONTRACT NUMBER Diagnosis of Prostate Cancer 5b. GRANT NUMBER...improve upon conventional Digital Rectal Examination (DRE) and PSA blood test by using ultrasound elasticity imaging. A latex sheath over the transrectal

Preparing for Citizenship: Bring Back John Dewey

ERIC Educational Resources Information Center

Pring, Richard

2016-01-01

The paper traces the development of citizenship in the curriculum in England since the 1960s, emerging particularly from the Crick report. It argues for lessons to be learnt from John Dewey's "Democracy and education", the centenary of which is being celebrated this year.

Human papilloma virus: An etiological and prognostic factor for oral cancer?

PubMed

Lafaurie, Gloria I; Perdomo, Sandra J; Buenahora, María R; Amaya, Sandra; Díaz-Báez, David

2018-05-01

The increasing prevalence of human papilloma virus (HPV)-positive oral tumors can be considered an epidemic. Although the incidence of HPV cervical cancer is decreasing, the incidence of oral cavity and oropharyngeal cancers associated with HPV is increasing. The presence of certain HPV genotypes could be a predictor of future oral cancer lesions, although lesions associated with HPV could be less aggressive and exhibit a higher survival rate. In the present study, we review the most important biologic, clinic, epidemiologic, and prognostic factors associated with HPV infection and oral cancer. © 2018 John Wiley & Sons Australia, Ltd.

The taboo of cancer: the experiences of cancer disclosure by Iranian patients, their family members and physicians.

PubMed

Zamanzadeh, Vahid; Rahmani, Azad; Valizadeh, Leila; Ferguson, Caleb; Hassankhani, Hadi; Nikanfar, Ali-Reza; Howard, Fuchsia

2013-02-01

The objective of this study is to describe the experiences of cancer disclosure by Iranian cancer patients, their family members and physicians. Twenty cancer patients, ten family members and eight physicians participated in this study. Data were collected via semi-structured, in-depth interviews and analyzed using qualitative content analysis. Three categories were identified: cancer avoidance, a climate of non-disclosure and mutual concern. The findings demonstrated that cancer is a taboo subject and the word cancer, as well as other indicative terms, was rarely used in daily communication. A climate of non-disclosure predominated because patients were the last to know their diagnosis, they were unaware of their prognosis, and family members and physicians employed strategies to conceal this information. The mutual concern of patients, family members and physicians was the main reason that cancer was not discussed. Cancer is a taboo subject in Iran that is maintained and reinforced primarily because of the mutual concern of patients, family members and physicians. The first step to address this taboo and inform cancer patients of their diagnosis would be to understand and help mitigate the individual, family and social consequences of disclosure. Copyright © 2011 John Wiley & Sons, Ltd.

Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer.

PubMed

Litwin, Monika; Dubis, Joanna; Arczyńska, Katarzyna; Piotrowska, Aleksandra; Frydlewicz, Anna; Karczewski, Maciej; Dzięgiel, Piotr; Witkiewicz, Wojciech

2015-06-01

Cancer stem cells (CSCs) constitute a sub-population of tumor cells that possess stem cell properties, such as self-renewal and the ability of differentiation. The presence of CSCs is associated with metastatic potential, treatment resistance and poor patient prognosis. Recently, aberrant expression of P-element induced wimpy testis proteins-PIWI (HIWI and HILI) has been identified in various types of tumors. The aim of the study was to evaluate the clinical significance of the HIWI and HILI expression and its relationship with cancer stem cells markers in 72 patients with colorectal carcinoma (CRC). The expression level of HIWI and HILI and cancer stem cells markers in paired cancerous and non-cancerous tissues was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. Immunohistochemistry was performed to confirm the observed changes on mRNA level and detect tissue localization of PIWI proteins. Significantly higher mRNA levels of HIWI and decreased HILI mRNA were measured in colorectal cancer tissues compared to corresponding non-cancerous samples. The changes in HIWI mRNA level in cancer tissues were correlated with OCT4 expression. Positive correlations between HILI level and SOX2 were also observed in cancerous tissues. Our results indicate a reciprocal regulation between HIWI, HILI and some CSCs markers in colorectal cancer. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Nietzsche, autobiography, history: mourning and Martin and John.

PubMed

Champagne, J

1998-01-01

How might gay and lesbian literature be read not as a mimetic representation of homosexuality, but as an activity linked to problems of subjectivity and historiography? Reading Dale Peck's novel Martin and John alongside passages from Friedrich Nietzsche's "On the Uses and Disadvantages of History for Life" and Sigmund Freud's "Mourning and Melancholia," this essay argues for an understanding of Peck's text as an attempt to link two apparently different processes of import to contemporary gay male subjects in particular: the writing of what Nietzsche terms "critical history," and the mourning of those lost to HIV disease. It concludes by linking Martin and John to feminist critiques of identity and traditional historiography, as well as noting the connection between these two critiques.

John Singleton Copley: "Portrait of Nathaniel Hurd."

ERIC Educational Resources Information Center

Buchanan, Penelope D.

1987-01-01

Presents a lesson plan based on John Singleton Copley's 1795 oil painting, "Portrait of Nathaniel Hurd." The goal of the lesson is to give students in grades four through six an awareness of portraiture and how portraits record not only character but historical times and customs. (JDH)

50th anniversary of the inauguration of John F. Kennedy

NASA Image and Video Library

2011-01-20

Caroline Kennedy, center, is recognized by U.S. Vice President Joe Biden, left, Senate Majority Leader Harry Reid (D-NV), second from left, former U.S. Labor Secretary Elaine Chao, and U.S. Senator John Kerry (D-MA), right, at an event recognizing the 50th anniversary of the inauguration of John F. Kennedy as President of the United States, Thursday, Jan. 20, 2011 in the rotunda at the U.S. Capitol. Photo Credit: (NASA/Bill Ingalls)

Fanconi anaemia: genetics, molecular biology, and cancer – implications for clinical management in children and adults.

PubMed

Schneider, M; Chandler, K; Tischkowitz, M; Meyer, S

2015-07-01

Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, cross-linker hypersensitivity and extreme cancer predisposition. With better understanding of the genetic and molecular basis of the disease, and improved clinical management, FA has been transformed from a life-limiting paediatric disease to an uncommon chronic condition that needs lifelong multidisciplinary management, and a paradigm condition for the understanding of the gene-environment interaction in the aetiology of congenital anomalies, haematopoiesis and cancer development. Here we review genetic, molecular and clinical aspects of FA, and discuss current controversies and future prospects. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

John White on Philosophy of Education and Philosophy

ERIC Educational Resources Information Center

Siegel, Harvey

2014-01-01

John White offers a provocative characterization of philosophy of education. In this brief reaction, I evaluate the characterization and urge the maintenance of a strong connection between philosophy of education and philosophy.

Accuracy of ultrasound in prediction of rectosigmoid infiltration in epithelial ovarian cancer.

PubMed

Zikan, M; Fischerova, D; Semeradova, I; Slama, J; Dundr, P; Weinberger, V; Dusek, L; Cibula, D

2017-10-01

To examine prospectively the accuracy of ultrasound in predicting rectosigmoid tumor infiltration in patients with epithelial ovarian cancer. Patients referred for a suspicious pelvic mass between 2012 and 2014 were examined by ultrasound following the standard protocol for assessment of tumor infiltration. Of the 245 patients examined, 191 had proven ovarian cancer and underwent primary surgery and were included in the analysis. Patients with apparently benign or inoperable disease were excluded. Rectosigmoid infiltration was evaluated by histopathology or according to perioperative findings. Clinical, pathological and laboratory parameters were analyzed as factors potentially affecting the sensitivity and specificity of sonography. The sensitivity of ultrasound in detecting rectosigmoid infiltration in patients with ovarian cancer was 86.3%, with specificity of 95.8%, positive predictive value of 92.6%, negative predictive value of 91.9% and overall accuracy of 92.1%. Ultrasound is a highly accurate method for detecting rectosigmoid tumor infiltration in ovarian cancer patients, and thus, can be used for planning adequate management, including patient consultation, surgical team planning, suitable operating time and postoperative care. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

Exploratory study of impact of cancer-related posttraumatic stress symptoms on diabetes self-management among cancer survivors.

PubMed

James, Janey; Harris, Yael T; Kronish, Ian M; Wisnivesky, Juan P; Lin, Jenny J

2018-02-01

Posttraumatic stress symptoms (PTSS) can be triggered by a diagnosis of a potentially life-threatening illness such as cancer. Little is known about the impact of cancer-related PTSS symptoms on self-management behaviors for comorbid chronic medical conditions such as diabetes mellitus (DM). We recruited patients with DM and a recent diagnosis of early-stage cancer from 2 medical centers in New York City. Cancer-related PTSS were assessed using the Impact of Events Scale (score ≥ 26). DM self-management behaviors (medication adherence, exercise, healthy diet, and glucose testing) were measured 3 months later. Logistic regression was used to assess the association between cancer-related PTSS symptoms and DM self-management behaviors, adjusting for gender, marital status, and anxiety symptoms. Of 56 participants recruited, 33% reported cancer-related PTSS symptoms. Elevated cancer-related PTSS symptoms were associated with lack of healthy diet (odds ratio: 0.08, 95% confidence interval: 0.01-0.62). Early-stage cancer survivors with cancer-related PTSS symptoms were less likely to adhere to some DM self-management behaviors. Providers should recognize the impact of cancer-related PTSS symptoms to better support comorbid disease management in cancer survivors. Copyright © 2017 John Wiley & Sons, Ltd.

The Trieste Lecture of John Stewart Bell

NASA Astrophysics Data System (ADS)

Bassi, Angelo; Carlo Ghirardi, Gian

2007-03-01

Delivered at Trieste on the occasion of the 25th Anniversary of the International Centre for Theoretical Physics, 2 November 1989 The video of this lecture is available here. Please see the PDF for the transcript of the lecture. General remarks by Angelo Bassi and GianCarlo Ghirardi During the autumn of 1989 the International Centre for Theoretical Physics, Trieste, celebrated the 25th anniversary of its creation. Among the many prestigious speakers, who delivered extremely interesting lectures on that occasion, was the late John Stewart Bell. All lectures have been recorded on tape. We succeeded in getting a copy of John's lecture. In the lecture, many of the arguments that John had lucidly stressed in his writings appear once more, but there are also extremely interesting new remarks which, to our knowledge, have not been presented elsewhere. In particular he decided, as pointed out by the very choice of the title of his lecture, to call attention to the fact that the theory presents two types of difficulties, which Dirac classified as first and second class. The former are those connected with the so-called macro-objectification problem, the latter with the divergences characterizing relativistic quantum field theories. Bell describes the precise position of Dirac on these problems and he stresses appropriately how, contrary to Dirac's hopes, the steps which have led to a partial overcoming of the second class difficulties have not helped in any way whatsoever to overcome those of the first class. He then proceeds to analyse the origin and development of the Dynamical Reduction Program and draws attention to the problems that still affect it, in particular that of a consistent relativistic generalization. When the two meetings Are there quantum jumps? and On the present status of Quantum Mechanics were organized in Trieste and Losinj (Croatia), on 5 10 September 2005, it occurred to us that this lecture, which has never been published, might represent an

John Greenleaf's life of science.

PubMed

Watenpaugh, Donald E

2012-12-01

This article summarizes the life and career of John E. Greenleaf, PhD. It complements an interview of Dr. Greenleaf sponsored by the American Physiological Society Living History Project found on the American Physiological Society website. Dr. Greenleaf is a "thought leader" and internationally renowned physiologist, with extensive contributions in human systems-level environmental physiology. He avoided self-aggrandizement and believed that deeds rather than words define one's legacy. Viewed another way, however, Greenleaf's words define his deeds: 48% of his 185 articles are first author works, which is an unusually high proportion for a scientist of his stature. He found that writing a thorough and thoughtful discussion section often led to novel ideas that drove future research. Beyond Greenleaf's words are the many students, postdocs, and collaborators lucky enough to have worked with him and thus learn and carry on his ways of science. His core principles included the following: avoid research "fads," embrace diversity, be the first subject in your own research, adhere to rules of fiscal responsibility, and respect administrative forces-but never back down from them when you know you are right. Greenleaf's integrity ensured he was usually right. He thrived on the axiom of many successful scientists: avoid falling in love with hypotheses, so that when unexpected findings appear, they arouse curiosity instead of fear. Dr. Greenleaf's legacy will include the John and Carol Greenleaf Award for prolific environmental and exercise-related publication in the Journal of Applied Physiology.

25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies.

PubMed

Grant, William B

2015-02-01

Existing literature includes concerns regarding reliability of case-control studies of breast cancer incidence with respect to 25-hydroxyvitamin D (25(OH)D) concentrations. For breast cancer, only case-control studies consistently find inverse correlations between 25(OH)D and breast cancer. However, for colorectal cancer, nested case-control studies find significant inverse correlations with respect to 25(OH)D concentrations at baseline for mean follow-up times of 7 years. This is a review of results currently existing in literature. I provide evidence that 25(OH)D concentration values are only useful for short follow-up times for breast cancer since it develops rapidly. To support the robust nature of breast cancer case-control studies, I show that results from 11 studies from seven countries align in a robust power-law fit to the odds ratio versus mean 25(OH)D concentrations. Case-control studies of breast cancer incidence rates provide reliable results. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

John Dewey in the 21st Century

ERIC Educational Resources Information Center

Williams, Morgan K.

2017-01-01

John Dewey was a pragmatist, progressivist, educator, philosopher, and social reformer (Gutek, 2014). Dewey's various roles greatly impacted education, and he was perhaps one of the most influential educational philosophers known to date (Theobald, 2009). Dewey's influence on education was evident in his theory about social learning; he believed…

Reflection on the "New Dynamics" of Distance Education: An Interview with Sir John Daniel

ERIC Educational Resources Information Center

Latchem, Colin

2012-01-01

This article presents an interview with Sir John Daniel outgoing President and CEO of the Commonwealth of Learning. Sir John Daniel's term as President and Chief Executive Officer of the Commonwealth of Learning (COL) ended on May 31, 2012. Readers of "Distance Education" will know of Sir John's work at the Tele-universite (Directeur des…

Astronaut John Young drives in One-G Lunar Roving Vehicle during simulation

NASA Image and Video Library

1971-03-04

Astronaut John W. Young, Apollo 16 prime crew commander (right), takes a drive in the One-G Lunar Roving Vehicle (LRV) trainer in the Lunar Topgraphic Simulation area at the Manned Spacecraft Center (MSC). He is accompanied by John Omstead, with General Electric, MSC.

Educational differences in likelihood of attributing breast symptoms to cancer: a vignette-based study.

PubMed

Marcu, Afrodita; Lyratzopoulos, Georgios; Black, Georgia; Vedsted, Peter; Whitaker, Katriina L

2016-10-01

Stage at diagnosis of breast cancer varies by socio-economic status (SES), with lower SES associated with poorer survival. We investigated associations between SES (indexed by education), and the likelihood of attributing breast symptoms to breast cancer. We conducted an online survey with 961 women (47-92 years) with variable educational levels. Two vignettes depicted familiar and unfamiliar breast changes (axillary lump and nipple rash). Without making breast cancer explicit, women were asked 'What do you think this […..] could be?' After the attribution question, women were asked to indicate their level of agreement with a cancer avoidance statement ('I would not want to know if I have breast cancer'). Women were more likely to mention cancer as a possible cause of an axillary lump (64%) compared with nipple rash (30%). In multivariable analysis, low and mid education were independently associated with being less likely to attribute a nipple rash to cancer (OR 0.51, 0.36-0.73 and OR 0.55, 0.40-0.77, respectively). For axillary lump, low education was associated with lower likelihood of mentioning cancer as a possible cause (OR 0.58, 0.41-0.83). Although cancer avoidance was also associated with lower education, the association between education and lower likelihood of making a cancer attribution was independent. Lower education was associated with lower likelihood of making cancer attributions for both symptoms, also after adjustment for cancer avoidance. Lower likelihood of considering cancer may delay symptomatic presentation and contribute to educational differences in stage at diagnosis. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

John Bardeen: an extraordinary physicist

NASA Astrophysics Data System (ADS)

Hoddeson, Lillian

2008-04-01

On the morning of 1 November 1956 the US physicist John Bardeen dropped the frying-pan of eggs that he was cooking for breakfast, scattering its contents on the kitchen floor. He had just heard that he had won the Nobel Prize for Physics along with William Shockley and Walter Brattain for their invention of the transistor. That evening Bardeen was startled again, this time by a parade of his colleagues from the University of Illinois marching to the door of his home bearing champagne and singing "For He's a Jolly Good Fellow".

Sociodemographic inequalities in barriers to cancer pain management: a report from the American Cancer Society's Study of Cancer Survivors-II (SCS-II).

PubMed

Stein, Kevin D; Alcaraz, Kassandra I; Kamson, Chelsey; Fallon, Elizabeth A; Smith, Tenbroeck G

2016-10-01

Research has increasingly documented sociodemographic inequalities in the assessment and management of cancer-related pain. Most studies have focused on racial/ethnic disparities, while less is known about the impact of other sociodemographic factors, including age and education. We analyzed data from a large, national, population-based study of cancer survivors to examine the influence of sociodemographic factors, and physical and mental health comorbidities on barriers to cancer pain management. The study included data from 4707 cancer survivors in the American Cancer Society's Study of Cancer Survivors-II, who reported experiencing pain from their cancer. A multilevel, socioecological, conceptual framework was used to generate a list of 15 barriers to pain management, representing patient, provider, and system levels. Separate multivariable logistic regressions for each barrier identified sociodemographic and health-related inequalities in cancer pain management, controlling for years since diagnosis, disease stage, and cancer treatment. Two-thirds of survivors reported at least 1 barrier to pain management. While patient-related barriers were most common, the greatest disparities were noted in provider- and system-level barriers. Specifically, inequalities by race/ethnicity, education, age, and physical and mental health comorbidities were observed. Findings indicate survivors who were nonwhite, less educated, older, and/or burdened by comorbidities were most adversely affected. Future efforts in research, clinical practice, and policy should identify and/or implement new strategies to address sociodemographic inequalities in cancer pain management. Copyright © 2016 John Wiley & Sons, Ltd.

Development of a novel oral vaccine against Mycobacterium avium paratuberculosis and Johne disease

PubMed Central

Johnston, C; Coffey, A; Sleator, RD

2010-01-01

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne disease, a granulomatous enteritis of cattle and other domesticated and wild ruminant species. Johne disease is prevalent worldwide and has a significant impact on the global agricultural economy. Current vaccines against Johne are insufficient in stemming its spread, and associated side-effects prevent their widespread use in control programs. Effective and safe vaccine strategies are needed. The main purpose of this paper is to propose and evaluate the development of a novel oral subunit-vaccine using a patho-biotechnological approach. This novel strategy, which harnesses patho-genetic elements from the intracellular pathogen Listeria monocytogenes, may provide a realistic route towards developing an effective next generation subunit vaccine against Johne disease and paratuberculosis. PMID:21326921

33 CFR 165.T08-290 - Safety Zone; Gulf of Mexico-Johns Pass, Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Gulf of Mexico-Johns... § 165.T08-290 Safety Zone; Gulf of Mexico—Johns Pass, Florida. (a) Regulated area. The Coast Guard is establishing a temporary safety zone on the waters of the Gulf of Mexico, Florida, in the vicinity of the John...

Fear of cancer recurrence and psychological well-being in women with breast cancer: The role of causal cancer attributions and optimism.

PubMed

Dumalaon-Canaria, J A; Prichard, I; Hutchinson, A D; Wilson, C

2018-01-01

This study aims to examine the association between cancer causal attributions, fear of cancer recurrence (FCR) and psychological well-being and the possible moderating effect of optimism among women with a previous diagnosis of breast cancer. Participants (N = 314) completed an online self-report assessment of causal attributions for their own breast cancer, FCR, psychological well-being and optimism. Simultaneous multiple regression analyses were conducted to explore the overall contribution of causal attributions to FCR and psychological well-being separately. Hierarchical multiple regression analyses were also utilised to examine the potential moderating influence of dispositional optimism on the relationship between causal attributions and FCR and psychological well-being. Causal attributions of environmental exposures, family history and stress were significantly associated with higher FCR. The attribution of stress was also significantly associated with lower psychological well-being. Optimism did not moderate the relationship between causal attributions and FCR or well-being. The observed relationships between causal attributions for breast cancer and FCR and psychological well-being suggest that the inclusion of causal attributions in screening for FCR is potentially important. Health professionals may need to provide greater psychological support to women who attribute their cancer to non-modifiable causes and consequently continue to experience distress. © 2016 John Wiley & Sons Ltd.

Negative cancer stereotypes and disease-specific self-concept in head and neck cancer.

PubMed

Wong, Janice C; Payne, Ada Y M; Mah, Kenneth; Lebel, Sophie; Lee, Ruth N F; Irish, Jonathan; Rodin, Gary; Devins, Gerald M

2013-05-01

Life-threatening diseases, such as head and neck cancer (HNCa), can stimulate the emergence of a new disease-specific self-concept. We hypothesized that (i) negative cancer-stereotypes invoke distancing, which inhibits the adoption of a disease-specific self-concept and (ii) patient characteristics, disease and treatment factors, and cancer-related stressors moderate the phenomenon. Head and neck cancer outpatients (N = 522) completed a semantic-differential measure of disease-specific self-concept (perceived similarity to the 'cancer patient') and other self-report measures in structured interviews. Negative cancer-stereotypes were represented by the number of semantic-differential dimensions (0-3) along which respondents evaluated the stereotypic 'cancer patient' negatively (i.e., negative valence). We tested the two-way interactions between negative valence and hypothesized moderator variables. We observed significant negative valence × moderator interactions for the following: (i) patient characteristics (education, employment, social networks); (ii) disease and treatment factors (cancer-symptom burden); and (iii) cancer-related stressors (uncertainty, lack of information, and existential threats). Negative cancer stereotypes were consistently associated with distancing of self from the stereotypic 'cancer patient,' but the effect varied across moderator variables. All significant moderators (except employment and social networks) were associated with increasing perceived similarity to the 'cancer patient' when respondents maintained negative stereotypes; perceived similarity decreased when people were employed or had extensive social networks. Moderator effects were less pronounced when respondents did not endorse negative cancer stereotypes. When they hold negative stereotypes, people with HNCa distance themselves from a 'cancer patient' identity to preserve self-esteem or social status, but exposure to cancer-related stressors and adaptive demands may

Resilience and positive affect contribute to lower cancer-related fatigue among Chinese patients with gastric cancer.

PubMed

Zou, Guiyuan; Li, Ye; Xu, Ruicai; Li, Ping

2018-04-01

To investigate the prevalence of cancer-related fatigue and explore the relationship between resilience, positive affect, and fatigue among Chinese patients with gastric cancer. Cancer-related fatigue is the most distressing symptom reported frequently by cancer patients during both treatment and survival phases. Resilience and positive affect as vital protective factors against cancer-related fatigue have been examined, but the underlying psychological mechanisms are not well understood. A cross-sectional study. Two hundred and three gastric cancer patients were enrolled from three hospitals in China. The Cancer Fatigue Scale, the positive affect subscale of the Positive and Negative Affect Schedule and the Connor-Davidson Resilience Scale (CD-RISC10) were administered. Hierarchical linear regression modelling was conducted to examine the association between resilience and cancer-related fatigue, and the mediating effect of positive affect. The incidence of clinically relevant fatigue among patients with gastric cancer was 91.6%. Regression analysis showed that resilience was negatively associated with cancer-related fatigue, explaining 15.4% of variance in cancer-related fatigue. Mediation analysis showed that high resilience was associated with increased positive affect, which was associated with decreased cancer-related fatigue. Cancer-related fatigue is prevalent among patients with gastric cancer. Positive affect may mediate the relationship between resilience and cancer-related fatigue. Interventions that attend to resilience training and promotion of positive affect may be the focus for future clinical and research endeavours. © 2017 John Wiley & Sons Ltd.

John Martin Wood (1938-2008)--pioneering biochemist, educator and communicator.

PubMed

Tobin, Desmond J; Pittelkow, Mark R; Slominski, Andrzej

2008-07-01

John Martin Wood, Emeritus Professor of Medical Biochemistry at the University of Bradford died in Wieck by Greifswald, Germany after a short illness on February 5, 2008 - just short of his 70(th) year. John worked as a pioneering biochemist and educator in the US and in Britain across two research careers. He devoted the first twenty-five years to the role of transition metals in biology, and his last twenty-years to cutaneous enzymology and melanogenesis. Working together with his wife Professor Karin U. Schallreuter, his research on oxidative stress handling in skin and on the expression of a cutaneous catecholaminergic system will help direct research in these fields for many years to come. John impressed on his fellow cutaneous researchers and students the critical importance of appreciating the true role of enzymes in skin health and disease. This obituary aims to contextualize the significant contributions made by this remarkable man to experimental dermatology.

Process and progress: John Hughlings Jackson's philosophy of science.

PubMed

Jacyna, L Stephen

2011-10-01

Some scepticism has been voiced over whether the work of John Hughlings Jackson possesses any significant philosophical orientation. This article argues that Hughlings Jackson was acquainted with the work of a wide range of philosophers. In particular, certain aspects of the writings of John Stuart Mill are reflected in Hughlings Jackson's own work. From early in his career, Hughlings Jackson adopted a critical stance in his neurological papers, seeking to expose shortcomings in the conventional practices of his peers and urging greater methodological rigour and sophistication in order to advance their science. This critical and 'procedurist' bias endows Hughlings Jackson's writings with a characteristically modern character.

Impact of depression on health utility value in cancer patients.

PubMed

Fujisawa, Daisuke; Inoguchi, Hironobu; Shimoda, Haruki; Yoshiuchi, Kazuhiro; Inoue, Shinichiro; Ogawa, Asao; Okuyama, Toru; Akechi, Tatsuo; Mimura, Masaru; Shimizu, Ken; Uchitomi, Yosuke

2016-05-01

The quality-adjusted life year, which is usually calculated from the health utility value, is now a standard measurement used in political decision-making in health. Although depression is the leading cause of decrement in health utility in general population, impact of comorbid depression among cancer patients has not been studied sufficiently. Therefore, this study aimed to measure the impact of depression on cancer patients' health utility score, according to the severity of depression. Impact of depression severity (measured by the Patient Health Questionnaire) on health utility score (measured by the EuroQoL-5 scale) was evaluated in a sample of 328 Japanese cancer patients, controlling for performance status, symptom burden, and demographic variables. The patients with depression had significantly lower health utility value than those without depression (mean decrement = 0.14). Decrements in health utility of 0.13, 0.18, and 0.19 were observed for mild, moderate, and moderately severe to severe level of depression, respectively. The difference was significant between groups. Depression severity was a significant predictor for health utility (standardized coefficient beta = -0.25), which was comparable with physical symptom burden and performance status. Participants' age, gender, cancer stage, and comorbid illness were not significant. The model explained 37.9% of the variance. Even mild level of depression caused clinically meaningful decrement in health utility value in cancer patients, which was comparable with decrements due to major physical complications of cancer. Influence of depression should be carefully investigated when interpreting the quality-adjusted life year among cancer patients. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

CCR’s Douglas Lowy and John Schiller receive the 2017 Lasker~DeBakey Clinical Medical Research Award | Center for Cancer Research

Cancer.gov

Douglas Lowy, M.D., and John Schiller, Ph.D., of CCR’s Laboratory of Cellular Oncology have received the 2017 Lasker~DeBakey Clinical Medical Research Award for their groundbreaking research leading to the development of human papillomavirus (HPV) vaccines. The Lasker Awards are widely regarded as the country’s most prestigious biomedical research prizes.

Evaluation of algorithms to identify incident cancer cases by using French health administrative databases.

PubMed

Ajrouche, Aya; Estellat, Candice; De Rycke, Yann; Tubach, Florence

2017-08-01

Administrative databases are increasingly being used in cancer observational studies. Identifying incident cancer in these databases is crucial. This study aimed to develop algorithms to estimate cancer incidence by using health administrative databases and to examine the accuracy of the algorithms in terms of national cancer incidence rates estimated from registries. We identified a cohort of 463 033 participants on 1 January 2012 in the Echantillon Généraliste des Bénéficiaires (EGB; a representative sample of the French healthcare insurance system). The EGB contains data on long-term chronic disease (LTD) status, reimbursed outpatient treatments and procedures, and hospitalizations (including discharge diagnoses, and costly medical procedures and drugs). After excluding cases of prevalent cancer, we applied 15 algorithms to estimate the cancer incidence rates separately for men and women in 2012 and compared them to the national cancer incidence rates estimated from French registries by indirect age and sex standardization. The most accurate algorithm for men combined information from LTD status, outpatient anticancer drugs, radiotherapy sessions and primary or related discharge diagnosis of cancer, although it underestimated the cancer incidence (standardized incidence ratio (SIR) 0.85 [0.80-0.90]). For women, the best algorithm used the same definition of the algorithm for men but restricted hospital discharge to only primary or related diagnosis with an additional inpatient procedure or drug reimbursement related to cancer and gave comparable estimates to those from registries (SIR 1.00 [0.94-1.06]). The algorithms proposed could be used for cancer incidence monitoring and for future etiological cancer studies involving French healthcare databases. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.

PubMed

Ng, Qin Xiang; Venkatanarayanan, Nandini; Ho, Collin Yih Xian

2017-03-01

St John's wort is a popular herbal remedy recommended by Traditional Chinese Medicine (TCM) practitioners and licensed and widely prescribed for depression in many European countries. However, conflicting data regarding its benefits and risks exist, and the last large meta-analysis on St John's wort use for depression was done in 2008, with no updated meta-analysis available. Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016. 27 clinical trials with a total of 3808 patients were reviewed, comparing the use of St John's wort and SSRI. In patients with depression, St John's wort demonstrated comparable response (pooled RR 0.983, 95% CI 0.924-1.042, p<0.001) and remission (pooled RR 1.013, 95% CI 0.892-1.134, p<0.001) rate, and significantly lower discontinuation/dropout (pooled OR 0.587, 95% CI 0.478-0.697, p<0.001) rate compared to standard SSRIs. The pooled SMD from baseline HAM-D scores (pooled SMD -0.068, 95% CI -0.127 to 0.021, p<0.001) also support its significant clinical efficacy in ameliorating depressive symptoms. Evidence on the long-term efficacy and safety of St. John's wort is limited as the duration of all available studies ranged from 4 to 12 weeks. It is also unclear if St John's wort would be beneficial for patients with severe depression, high suicidality or suicide risk. For patients with mild-to-moderate depression, St John's wort has comparable efficacy and safety when compared to SSRIs. Follow-up studies carried out over a longer duration should be planned to ascertain its benefits. Copyright © 2017 Elsevier B.V. All rights

Spatial analyses identify the geographic source of patients at a National Cancer Institute Comprehensive Cancer Center.

PubMed

Su, Shu-Chih; Kanarek, Norma; Fox, Michael G; Guseynova, Alla; Crow, Shirley; Piantadosi, Steven

2010-02-01

We examined the geographic distribution of patients to better understand the service area of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, a designated National Cancer Institute (NCI) comprehensive cancer center located in an urban center. Like most NCI cancer centers, the Sidney Kimmel Comprehensive Cancer Center serves a population beyond city limits. Urban cancer centers are expected to serve their immediate neighborhoods and to address disparities in access to specialty care. Our purpose was to learn the extent and nature of the cancer center service area. Statistical clustering of patient residence in the continental United States was assessed for all patients and by gender, cancer site, and race using SaTScan. Primary clusters detected for all cases and demographically and tumor-defined subpopulations were centered at Baltimore City and consisted of adjacent counties in Delaware, Pennsylvania, Virginia, West Virginia, New Jersey and New York, and the District of Columbia. Primary clusters varied in size by race, gender, and cancer site. Spatial analysis can provide insights into the populations served by urban cancer centers, assess centers' performance relative to their communities, and aid in developing a cancer center business plan that recognizes strengths, regional utility, and referral patterns. Today, 62 NCI cancer centers serve a quarter of the U.S. population in their immediate communities. From the Baltimore experience, we might project that the population served by these centers is actually more extensive and varies by patient characteristics, cancer site, and probably cancer center services offered.

Nanotechnology in the management of cervical cancer.

PubMed

Chen, Jiezhong; Gu, Wenyi; Yang, Lei; Chen, Chen; Shao, Renfu; Xu, Kewei; Xu, Zhi Ping

2015-03-01

Cervical cancer is a major disease with high mortality. All cervical cancers are caused by infection with human papillomaviruses (HPV). Although preventive vaccines for cervical cancer are successful, treatment of cervical cancer is far less satisfactory because of multidrug resistance and side effects. In this review, we summarize the recent application of nanotechnology to the diagnosis and treatment of cervical cancer as well as the development of HPV vaccines. Early detection of cervical cancer enables tumours to be efficiently removed by surgical procedures, leading to increased survival rate. The current method of detecting cervical cancer by Pap smear can only achieve 50% sensitivity, whereas nanotechnology has been used to detect HPVs with greatly improved sensitivity. In cervical cancer treatment, nanotechnology has been used for the delivery of anticancer drugs to increase treatment efficacy and decrease side effects. Nanodelivery of HPV preventive and therapeutic vaccines has also been investigated to increase vaccine efficacy. Overall, these developments suggest that nanoparticle-based vaccine may become the most effective way to prevent and treat cervical cancer, assisted or combined with some other nanotechnology-based therapy. Copyright © 2015 John Wiley & Sons, Ltd.

John R. Commons: Pioneer in Labor Economics.

ERIC Educational Resources Information Center

Barbash, Jack

1989-01-01

John R. Commons has contributed in one way or another to pratically every piece of social and labor legislation that has been enacted in the twentieth century. He has made his mark on such diverse aspects of American labor as apprenticeship, vocational education, workers' compensation, and the administration of labor law. (Author/JOW)

MPI Enhancements in John the Ripper

NASA Astrophysics Data System (ADS)

Sykes, Edward R.; Lin, Michael; Skoczen, Wesley

2010-11-01

John the Ripper (JtR) is an open source software package commonly used by system administrators to enforce password policy. JtR is designed to attack (i.e., crack) passwords encrypted in a wide variety of commonly used formats. While parallel implementations of JtR exist, there are several limitations to them. This research reports on two distinct algorithms that enhance this password cracking tool using the Message Passing Interface. The first algorithm is a novel approach that uses numerous processors to crack one password by using an innovative approach to workload distribution. In this algorithm the candidate password is distributed to all participating processors and the word list is divided based on probability so that each processor has the same likelihood of cracking the password while eliminating overlapping operations. The second algorithm developed in this research involves dividing the passwords within a password file equally amongst available processors while ensuring load-balanced and fault-tolerant behavior. This paper describes John the Ripper, the design of these two algorithms and preliminary results. Given the same amount of time, the original JtR can crack 29 passwords, whereas our algorithms 1 and 2 can crack an additional 35 and 45 passwords respectively.

The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.

PubMed

Matlung, Hanke L; Szilagyi, Katka; Barclay, Neil A; van den Berg, Timo K

2017-03-01

Immune checkpoint inhibitors, including those targeting CTLA-4/B7 and the PD-1/PD-L1 inhibitory pathways, are now available for clinical use in cancer patients, with other interesting checkpoint inhibitors being currently in development. Most of these have the purpose to promote adaptive T cell-mediated immunity against cancer. Here, we review another checkpoint acting to potentiate the activity of innate immune cells towards cancer. This innate immune checkpoint is composed of what has become known as the 'don't-eat me' signal CD47, which is a protein broadly expressed on normal cells and often overexpressed on cancer cells, and its counter-receptor, the myeloid inhibitory immunoreceptor SIRPα. Blocking CD47-SIRPα interactions has been shown to promote the destruction of cancer cells by phagocytes, including macrophages and neutrophils. Furthermore, there is growing evidence that targeting of the CD47-SIRPα axis may also promote antigen-presenting cell function and thereby stimulate adaptive T cell-mediated anti-cancer immunity. The development of CD47-SIRPα checkpoint inhibitors and the potential side effects that these may have are discussed. Collectively, this identifies the CD47-SIRPα axis as a promising innate immune checkpoint in cancer, and with data of the first clinical studies with CD47-SIRPα checkpoint inhibitors expected within the coming years, this is an exciting and rapidly developing field. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

78 FR 57063 - Special Local Regulations; Jacksonville Dragon Boat Festival; St. Johns River; Jacksonville, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-17

... 1625-AA08 Special Local Regulations; Jacksonville Dragon Boat Festival; St. Johns River; Jacksonville... Special Local Regulation on the waters of the St. Johns River in Jacksonville, Florida during the... portion of the St. Johns River. Non-participant persons and vessels will be prohibited from entering or...

Attending to insects: Francis Willughby and John Ray

PubMed Central

Ogilvie, Brian W.

2012-01-01

Francis Willughby and John Ray were at the forefront of the natural history of insects in the second half of the seventeenth century. Willughby in particular had a deep interest in insects' metamorphosis, behaviour and diversity, an interest that he passed on to his friend and mentor Ray. By examining Willughby's contributions to John Wilkins's Essay towards a Real Character (1668) and Ray's Methodus insectorum (1705) and Historia insectorum (1710), which contained substantial material from Willughby's manuscript history of insects, one may reconstruct how the two naturalists studied insects, their innovative use of metamorphosis in insect classification, and the sheer diversity of insect forms that they described on the basis of their own collections and those of London and Oxford virtuosi. Imperfect as it was, Historia insectorum was recognized by contemporaries as a significant contribution to the emerging field of entomology.

Astronaut John Glenn - Crew Quarters - Prelaunch - Cape

NASA Image and Video Library

1962-02-20

S62-00377 (20 Feb. 1962) --- Astronaut John H. Glenn Jr., walking out of building with Dr. William K. Douglas (to Glenn's left), and Joe W. Schmitt, NASA's suit technician (in front of Dr. Douglas). This Mercury Atlas 6 (MA-6) ?Friendship 7? flight marks America's first manned Earth-orbiting spaceflight. Photo credit: NASA

John Thomson: Photojournalist in Asia, 1862-1872.

ERIC Educational Resources Information Center

Parker, Elliott S.

John Thomson was a nineteenth-century British photojournalist who used the wet-plate process to illustrate his explorations of eastern and Southeast Asia. His travels from 1862 to 1872 took him to the following places, among others: Ceylon, Cambodia, Singapore, Thailand, Saigon, Siam, mainland China, and Taiwan. Thomson chose to use the wet-plate…

HARPERS FERRY, A PLAY ABOUT JOHN BROWN.

ERIC Educational Resources Information Center

STAVIS, BARRIE

THIS PLAY IS A DRAMATIC RENDERING OF JOHN BROWN'S ATTACK ON THE ARMORY AT HARPERS FERRY AND HIS SUBSEQUENT TRIAL FOR TREASON. ALTHOUGH IT ADHERES TO THE FACTS OF HISTORY, THEY ARE NOT TREATED REALISTICALLY. "HARPERS FERRY" PORTRAYS BROWN AS POSSESSING A PURE IDEALISM UNTAINTED IN THE SLIGHTEST DEGREE BY MATERIALISM OR SELF-SEEKING, WHICH…

Remembering NASA Astronaut John Young, 1930-2018

NASA Image and Video Library

2018-01-06

Astronaut John Young, who walked on the Moon during Apollo 16 and commanded the first space shuttle mission, has passed away at the age of 87. This video tribute, which includes music and portions of Young’s own words from previous interviews and events, recounts some of the highlights of his storied career at NASA.

6. South View of Whitneyville in Hamden, 1836 by John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. South View of Whitneyville in Hamden, 1836 by John Warner Barber Photocopied from John Warner Barber, Connecticut Historical Collections (New Haven, 1856), p. 220. 'The engraving... shows the appearance of the little village of Whitneyville, as seen from a few rods south, on the New Haven road.' (Barber, p. 219). The right fork, with Ithiel Town's truss, carries the New Haven & Hartford Turnpike, the left the Cheshire Turnpike. The factory is on the right, the village on the left. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

The Influence of John Dewey on Experimental Colleges: The Black Mountain Example.

ERIC Educational Resources Information Center

Reynolds, Katherine C.

This paper discusses the influence of John Dewey and his educational philosophy and methods on the development of experimental liberal arts colleges during the 1930s. It reviews the student-centered, holistic, experiential curriculum advocated by Dewey and others, and the role of John Andrew Rice in founding Black Mountain College near Black…

John Lubbock, science, and the liberal intellectual

PubMed Central

Clark, J. F. M.

2014-01-01

John Lubbock's longest-standing scientific research interest was entomology. Some of his earliest systematic investigations of insect and marine life began under the tutelage of Darwin. Darwin shaped the trajectory of, and the programme for, Lubbock's natural history work. However, to understand John Lubbock's identity as a scientist, he must be located within the context of the Victorian ‘intellectual’. This paper traces Lubbock's entomological work from its early development under Darwin to his later work on insect sensory physiology and comparative psychology. Far from being the death of his scientific career, Lubbock's entry into Parliament marked the pinnacle of his career as a scientific intellectual. He built on his early work on invertebrate anatomy, physiology and taxonomy, and on his archaeological and anthropological research to expound his vision of mental evolution. His research on ‘savages’, on ants, bees and wasps, and on his dog, ‘Van’, permitted him to expatiate upon the psychic unity of all sentient beings, which, in turn, underpinned his overarching educational programme.

Ral signaling pathway in health and cancer.

PubMed

Moghadam, Adel Rezaei; Patrad, Elham; Tafsiri, Elham; Peng, Warner; Fangman, Benjamin; Pluard, Timothy J; Accurso, Anthony; Salacz, Michael; Shah, Kushal; Ricke, Brandon; Bi, Danse; Kimura, Kyle; Graves, Leland; Najad, Marzieh Khajoie; Dolatkhah, Roya; Sanaat, Zohreh; Yazdi, Mina; Tavakolinia, Naeimeh; Mazani, Mohammad; Amani, Mojtaba; Ghavami, Saeid; Gartell, Robyn; Reilly, Colleen; Naima, Zaid; Esfandyari, Tuba; Farassati, Faris

2017-12-01

The Ral (Ras-Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown that the activation of RalA in cancer stem cells is higher in comparison with differentiated cancer cells. In this article, we review the role of Ral signaling in health and disease with a focus on the role of this multifunctional protein in the generation of therapies for cancer. An improved understanding of this pathway can lead to development of a novel class of anticancer therapies that functions on the basis of intervention with RalA or its downstream effectors. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer: results of "Cancer POP" study.

PubMed

Jung, Jiwon; Moon, Song Mi; Jang, Hee-Chang; Kang, Cheol-In; Jun, Jae-Bum; Cho, Yong Kyun; Kang, Seung-Ji; Seo, Bo-Jeong; Kim, Young-Joo; Park, Seong-Beom; Lee, Juneyoung; Yu, Chang Sik; Kim, Sung-Han

2018-01-01

The aim of this study was to investigate the incidence and risk factors of postoperative pneumonia (POP) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [HCC]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult patients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One-year cumulative incidence of POP was estimated using Kaplan-Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1-year cumulative incidence of POP was 2.0% (95% CI, 1.4-2.6). The 1-year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index (CCI) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1-year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

John M. Eisenberg Patient Safety and Quality Awards.

PubMed

2009-12-01

The Joint Commission Journal on Quality and Patient Safety is honored to publish articles on the recipients of the annual John M. Eisenberg Patient Safety and Quality Awards. This year, a new category was created: individual achievement at the international level.

Fossil Flora of the John Day Basin, Oregon

USGS Publications Warehouse

Knowlton, Frank Hall

1902-01-01

For a number of years I have been gradually accumulating material for a thorough revision of the Tertiary floras of the Pacific slope. Fossil plants are known to occur at numerous points within this area, and their study and identification has already furnished valuable data bearing on the geological history of the region, and when still further exploited it is confidently expected that they will afford more exact data for the use of geologists. This investigation is progressing satisfactorily, and at no distant day it is hoped to have it in form for final publication. From time to time various members of the United States Geological Survey, as well as others not connected with this organization, have sent in small collections of fossil plants for determination. These have been studied and reported upon as fully as the condition of the problem permitted, so that the determinations could be immediately available to geologists, but with the reservation that none of the questions could be fully settled until all known material had been studied and properly correlated. The rich fossil plant deposits in the John Day Basin, as set forth more fully in the historical account which follows, have been known for a period of nearly fifty years, but their study has been carried on in a more or less desultory manner. There has also been considerable confusion as to the horizons whence these plants came. As various species of plants described originally from the John Day region were detected in various other localities in Oregon, and in surrounding areas, as central Washington, western Idaho, and northern California, it became more than ever apparent that a thorough study of all material obtainable from this type area would be necessary before any definite or satisfactory conclusions could be reached. The immediate incentive for this revision was furnished by the receipt of a considerable collection of plants, made by Dr. John C. Merriam in 1900 while he was in charge of an

Five scientists at Johns Hopkins in the modern evolution of neuroscience.

PubMed

Harrison, T S

2000-08-01

Neuroscience's evolution at Johns Hopkins, from neurophysiology to the new field of neurobiology, though unplanned, was rapid and important. Beginning in 1933 when Philip Bard became professor of physiology at Johns Hopkins, members of his department concentrated initially on neuroanatomical control of placing reactions and sexual activity. Vernon Mountcastle, extending available techniques, discovered vertical somato-sensory columns in the 1950's. Stephen Kuffler, who arrived at Hopkins in 1947, was a pioneer in single unit microelectrode recording techniques. He soon attracted scientists from all over the world to his laboratory. Among them, Torsten Wiesel and David Hubel discovered vertical neuronal columns in the visual cortex. During several decades at Johns Hopkins, these five scientists set extremely high scientific standards and established a climate of inquiry in which ideas were shared and young scientists encouraged. They contributed significantly to the emerging discipline of neuroscience.

Disability in the Family: John and Alice Dewey Raising Their Son Sabino

ERIC Educational Resources Information Center

Danforth, Scot

2018-01-01

Background/Context: The current biographic understanding of John Dewey's experience adopting and raising an Italian boy named Sabino emphasizes the theme of finding an emotional replacement for Morris and Gordon, two young sons who had tragically died on family trips to Europe. Lacking is substantive attention to the fact that John Dewey's son had…

John Dewey's Influence on Turkish Education System in the Early Republic Era

ERIC Educational Resources Information Center

Sahin, Mustafa

2017-01-01

In this research, the influence of John Dewey's visit to Turkey in 1924, his report on Turkish education system and its influence on Turkish education system in the early republic era were discussed. John Dewey was invited by Ministry of Education in 1924. He made investigations concerning the education system, participated in interviews, and…

A Posthumous Dialogue with John Nicolis: IERU

NASA Astrophysics Data System (ADS)

Rössler, Otto E.

2014-12-01

The reader is taken into the heart of a fictitious dialogue between two friends who never talked long enough with each other during the lifetime of both. It is the fearlessness of the mind of John that prompted the hopefully not too erratic thoughts that are going to be offered. The central figure is Heraclitus, the Great.

Capitalism in Six Westerns by John Ford

ERIC Educational Resources Information Center

Braun, Carlos Rodriguez

2011-01-01

The economic and institutional analysis of capitalism can be illustrated through John Ford's Westerns. This article focuses on six classics by Ford that show the move toward modern order, the creation of a new society, and the rule of law. Economic features are pervading, from property rights and contracts to markets, money, and trade. Ford has…

John Young-NASA’s Longest Serving Astronaut

NASA Image and Video Library

2018-01-06

This music video takes a look back at the NASA career of astronaut John Young, who died Friday night following complications from pneumonia at the age of 87. Young is the only agency astronaut to go into space as part of the Gemini, Apollo and space shuttle programs, and the first to fly into space six times.

78 FR 42972 - Notice of Intent To Collect Fees on the John Day River, Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

...) to Tumwater Falls (River Mile 10) stretch of the John Day River, between Service Creek, Oregon, and... business hours. SUPPLEMENTARY INFORMATION: The Service Creek to Tumwater Falls stretch of the John Day... float within the Service Creek to Tumwater Falls stretch of the John Day River. All fees collected would...

78 FR 64236 - Notice of Public Meeting for the John Day; Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

...] Notice of Public Meeting for the John Day; Snake Resource Advisory Council AGENCY: Bureau of Land... Interior, Bureau of Land Management (BLM), the John Day--Snake Resource Advisory Council (RAC) will meet as indicated below: DATES: The John Day--Snake RAC will hold a public meeting Thursday and Friday, November 14...

International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data.

PubMed

Zhang, Junjun; Baran, Joachim; Cros, A; Guberman, Jonathan M; Haider, Syed; Hsu, Jack; Liang, Yong; Rivkin, Elena; Wang, Jianxin; Whitty, Brett; Wong-Erasmus, Marie; Yao, Long; Kasprzyk, Arek

2011-01-01

The International Cancer Genome Consortium (ICGC) is a collaborative effort to characterize genomic abnormalities in 50 different cancer types. To make this data available, the ICGC has created the ICGC Data Portal. Powered by the BioMart software, the Data Portal allows each ICGC member institution to manage and maintain its own databases locally, while seamlessly presenting all the data in a single access point for users. The Data Portal currently contains data from 24 cancer projects, including ICGC, The Cancer Genome Atlas (TCGA), Johns Hopkins University, and the Tumor Sequencing Project. It consists of 3478 genomes and 13 cancer types and subtypes. Available open access data types include simple somatic mutations, copy number alterations, structural rearrangements, gene expression, microRNAs, DNA methylation and exon junctions. Additionally, simple germline variations are available as controlled access data. The Data Portal uses a web-based graphical user interface (GUI) to offer researchers multiple ways to quickly and easily search and analyze the available data. The web interface can assist in constructing complicated queries across multiple data sets. Several application programming interfaces are also available for programmatic access. Here we describe the organization, functionality, and capabilities of the ICGC Data Portal.

STS-100 Crew Interview: John Phillips

NASA Technical Reports Server (NTRS)

2001-01-01

STS-100 Mission Specialist John Phillips is seen being interviewed. He answers questions about his inspiration to become an astronaut and his career path. He gives details on the mission's goals and significance, the rendezvous and docking of Endeavour with the International Space Station (ISS), the mission's spacewalks, and installation and capabilities of the Space Station robotic arm, UHF antenna, and Rafaello Logistics Module. Phillips then discusses his views about space exploration as it becomes an international collaboration.

John C. Stennis Space Center overview

NASA Astrophysics Data System (ADS)

1994-05-01

An overview of research being conducted at the John C. Stennis Space Center is given. The Space Center is not only a NASA Space Flight Center, but also houses facilities for 22 other governmental agencies. The programs described are Stennis' High Heat Flux Facility, the Component Test Facility (used to test propulsion rockets and for the development of the National Aerospace Plane), oceanographic and remote sensing research, and contributions to the development of Space Station Freedom.

78 FR 76175 - Notice of Public Meeting for the John Day-Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

...] Notice of Public Meeting for the John Day-Snake Resource Advisory Council AGENCY: Bureau of Land... Interior, Bureau of Land Management (BLM), the John Day-Snake Resource Advisory Council (RAC) will meet as indicated below: DATES: The John Day-Snake RAC will hold a public meeting Thursday and Friday, January 9 and...

Of Curriculum Conceptions, Orientations, and Cultures: A Rejoinder to John E. Hull

ERIC Educational Resources Information Center

Van Brummelen, Harro

2009-01-01

In this article, the author presents a rejoinder to John E. Hull. Van Brummelen first states his appreciation of John Hull's thoughtful evaluation of his views of curriculum, views in which many Christian educators have played a part. It has been several decades since the author spelled out what Hull calls an "education for discipleship"…

John Dewey and the Art of Teaching: Toward Reflective and Imaginative Practice

ERIC Educational Resources Information Center

Simpson, Douglas J.; Jackson, Michael J. B.; Aycock, Judy C.

2004-01-01

"John Dewey and the Art of Teaching: Toward Reflective and Imaginative Practice" is an engaging and accessible introduction to the art of teaching as seen through the eyes of John Dewey. Authors Douglas J. Simpson, Michael J. B. Jackson, and Judy C. Aycock provide a lucid interpretation of the complexities and art of teaching in contemporary…

Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content.

PubMed

Chrubasik-Hausmann, Sigrun; Vlachojannis, Julia; McLachlan, Andrew J

2018-02-07

The aim of this study was to review herb-drug interaction studies with St John's wort (Hypericum perforatum L.) with a focus on the hyperforin content of the extracts used in these studies. PUBMED was systematically searched to identify studies describing pharmacokinetic interactions involving St John's wort. Data on study design and the St John's wort extract or product were gathered to extract hyperforin content and daily dose used in interaction studies. This analysis demonstrates that significant herb-drug interactions (resulting in a substantial change in systemic exposure) with St John's wort products were associated with hyperforin daily dosage. Products that had a daily dose of <1 mg hyperforin were less likely to be associated with major interaction for drugs that were CYP3A4 or p-glycoprotein substrates. Although a risk of interactions cannot be excluded even for low-dose hyperforin St. John's wort extracts, the use of products that result in a dose of not more than 1 mg hyperforin per day is recommended to minimise the risk of interactions. This review highlights that the significance of herb-drug interactions with St John's wort is influenced by the nature of the herbal medicines product, particularly the hyperforin content. © 2018 Royal Pharmaceutical Society.

Howard Parnes, MD | Division of Cancer Prevention

Cancer.gov

Dr. Howard Parnes received a BA from Cornell University in 1977 and an MD from the University of Medicine and Dentistry of New Jersey in 1981. He trained in internal medicine at the Johns Hopkins Bayview Medical Center from 1981 to 1984 followed by a medical oncology fellowship at the University of Maryland Cancer Center (UMCC) from 1984 to 1987. |

John A. Davidson: Coccidologist, artist, teacher and naturalist

USDA-ARS?s Scientific Manuscript database

Dr. John Davidson was honored at the XIV International Symposium on Scale Insect Studies with the Career Achievement award for his outstanding research on scale insects, particularly armored scales. His contributions with colleagues and students include a comprehensive treatise on the economic armo...

Selective Activation of a Perforin-Granzyme B Fusion Protein Toxin by PSA as Therapy for Metastatic Prostate Cancer

DTIC Science & Technology

2016-10-01

Prostate Cancer PRINCIPAL INVESTIGATOR: Samuel Denmeade RECIPIENT: Johns Hopkins University Baltimore, MD 21218 REPORT DATE: October 2016 TYPE...PSA as Therapy for Metastatic Prostate Cancer 5b. GRANT NUMBER W81XWH-15-1-0382 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Samuel R Denmeade...cytotoxic agent that can selectively kill both proliferating and non-proliferating prostate cancer cells within a metastatic site without significant host

Illustrations enhance older colorectal cancer patients' website satisfaction and recall of online cancer information.

PubMed

Bol, N; Smets, E M A; Eddes, E H; de Haes, J C J M; Loos, E F; van Weert, J C M

2015-03-01

This study aims to investigate the effects of illustrations in online cancer information on older cancer patients' website satisfaction (i.e. satisfaction with the attractiveness, comprehensibility and emotional support from the website) and recall of information. In an online experiment, 174 younger (<65 years) and older (≥65 years) colorectal cancer patients were randomly exposed to a webpage about transanal endoscopic microsurgery consisting of either text-only information, text with two cognitive illustrations or text with two affective illustrations. In general, adding cognitive illustrations compared with text-only information improved the satisfaction with the attractiveness of the website in both younger and older patients. For older patients in particular, cognitive illustrations facilitated recall of cancer information: whereas older patients recalled less information overall compared with younger patients (39% vs. 50%), no statistically significant differences in age on recall were observed when cognitive illustrations were added to text. Furthermore, older patients were more satisfied with the emotional support from the website than younger patients, especially when affective illustrations were present. Our results suggest that effective online cancer communication for ageing populations involves considering both cognitive and affective illustrations to enhance website satisfaction and recall of cancer information. © 2015 John Wiley & Sons Ltd.

Utilization of health care services in cancer patients with elevated fear of cancer recurrence.

PubMed

Champagne, Alexandra; Ivers, Hans; Savard, Josée

2018-05-02

Cancer patients commonly report experiencing fear of cancer recurrence (FCR), which may lead to several negative consequences. This study aimed at examining whether clinical levels of FCR are linked to a greater use of health care services. This is a secondary analysis of a longitudinal study of 962 cancer patients on the epidemiology of cancer-related insomnia. They completed the Fear of Cancer Recurrence Inventory-Short form (FCRI-SF) and reported information on their consultations (medical, psychosocial, and complementary and alternative medicine [CAM]) and medication usage (anxiolytics/hypnotics and antidepressants) at 6 time points over an 18-month period. Results indicated that clinical FCR at baseline was associated with greater consultation rates of medical and psychosocial professionals and a greater usage of anxiolytics/hypnotics and antidepressants. No significant association was found between the FCR level and use of CAM services. While consultation rates of medical and CAM professionals and usage of antidepressants generally increased over time, consultation rates of psychosocial professionals and usage of anxiolytics/hypnotics tended to decrease. Cancer patients with clinical levels of FCR are more likely to consult health care providers and to use psychotropic medications, which may translate into significant costs for society and the patients themselves. Copyright © 2018 John Wiley & Sons, Ltd.

Sustaining Reliability on Accountability Measures at The Johns Hopkins Hospital.

PubMed

Pronovost, Peter J; Holzmueller, Christine G; Callender, Tiffany; Demski, Renee; Winner, Laura; Day, Richard; Austin, J Matthew; Berenholtz, Sean M; Miller, Marlene R

2016-02-01

In 2012 Johns Hopkins Medicine leaders challenged their health system to reliably deliver best practice care linked to nationally vetted core measures and achieve The Joint Commission Top Performer on Key Quality Measures ®program recognition and the Delmarva Foundation award. Thus, the Armstrong Institute for Patient Safety and Quality implemented an initiative to ensure that ≥96% of patients received care linked to measures. Nine low-performing process measures were targeted for improvement-eight Joint Commission accountability measures and one Delmarva Foundation core measure. In the initial evaluation at The Johns Hopkins Hospital, all accountability measures for the Top Performer program reached the required ≥95% performance, gaining them recognition by The Joint Commission in 2013. Efforts were made to sustain performance of accountability measures at The Johns Hopkins Hospital. Improvements were sustained through 2014 using the following conceptual framework: declare and communicate goals, create an enabling infrastructure, engage clinicians and connect them in peer learning communities, report transparently, and create accountability systems. One part of the accountability system was for teams to create a sustainability plan, which they presented to senior leaders. To support sustained improvements, Armstrong Institute leaders added a project management office for all externally reported quality measures and concurrent reviewers to audit performance on care processes for certain measure sets. The Johns Hopkins Hospital sustained performance on all accountability measures, and now more than 96% of patients receive recommended care consistent with nationally vetted quality measures. The initiative methods enabled the transition of quality improvement from an isolated project to a way of leading an organization.

LINC00152: A pivotal oncogenic long non-coding RNA in human cancers.

PubMed

Yu, Yang; Yang, Jian; Li, Quanpeng; Xu, Boming; Lian, Yifan; Miao, Lin

2017-08-01

In recent years, increasing evidence has shown the potential role of long non-coding RNAs (lncRNAs) in multiple cancers. Deregulation of lncRNAs was detected being closely associated with many kinds of tumours where they can act as a tumour suppressor or accelerator. LINC00152 was identified as an oncogene involved in many kinds of cancers, such as gastric cancer, hepatocellular carcinoma, colon cancer, gallbladder cancer and renal cell carcinoma. Moreover, inhibition of LINC00152 can suppress proliferation, migration and invasion of the cancer cells. Increasing evidence has showed that LINC00152 may act as a diagnostic and prognostic biomarker for the above-mentioned cancers. In our review, we summarize the recent research progress of the expression and role of LINC00152 in various kinds of cancers. © 2017 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

C-C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment.

PubMed

Urata, Satoko; Izumi, Kouji; Hiratsuka, Kaoru; Maolake, Aerken; Natsagdorj, Ariunbold; Shigehara, Kazuyoshi; Iwamoto, Hiroaki; Kadomoto, Suguru; Makino, Tomoyuki; Naito, Renato; Kadono, Yoshifumi; Lin, Wen-Jye; Wufuer, Guzailinuer; Narimoto, Kazutaka; Mizokami, Atsushi

2018-03-01

Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity in the prostate cancer bone metastasis microenvironment. Growth and migration of human prostate cancer cells were assayed in cocultures with bone stromal cells. The migration of LNCaP cells significantly increased when co-cultured with bone stromal cells isolated from prostate cancer bone metastases. Cytokine array analysis of conditioned medium from bone stromal cell cultures identified CCL5 as a concentration-dependent promoter of LNCaP cell migration. The migration of LNCaP cells was suppressed when C-C motif ligand 5 (CCL5) neutralizing antibody was added to cocultures with bone stromal cells. Knockdown of androgen receptor with small interfering RNA increased the migration of LNCaP cells compared with control cells, and CCL5 did not promote the migration of androgen receptor knockdown LNCaP. Elevated CCL5 secretion in bone stromal cells from metastatic lesions induced prostate cancer cell migration by a mechanism consistent with CCL5 activity upstream of androgen receptor signaling. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Outcomes in revision Tommy John surgery in Major League Baseball pitchers.

PubMed

Liu, Joseph N; Garcia, Grant H; Conte, Stan; ElAttrache, Neal; Altchek, David W; Dines, Joshua S

2016-01-01

With the recent rise in the number of Tommy John surgeries, a proportionate rise in revisions is expected. However, much is unknown regarding the current revision rate of Tommy John surgery, return to play, and change in performance in Major League Baseball (MLB) pitchers. Publicly available databases were used to obtain a list of all MLB pitchers who underwent primary and revision Tommy John surgery. Pitching performance preoperatively and postoperatively for pitchers who returned to 1 or more MLB games after revision surgery was compared with controls matched for age and position. Since 1999, 235 MLB pitchers have undergone Tommy John surgeries; 31 pitchers (13.2%) underwent revision surgery, and 37% underwent revision within 3 years of the index procedure. Twenty-six revisions had more than 2 years of follow-up; 17 pitchers (65.4%) returned to pitch at least 1 major league game, whereas only 11 (42.3%) returned to pitch 10 or more games. Of those who returned to MLB competition, the average length of recovery was 20.76 months. Compared with controls matched for age and position, MLB pitchers undergoing revision surgery had a statistically shorter career after revision surgery (4.9 vs 2.6 seasons, P = .002), pitched fewer innings, and had fewer total pitches per season. The rate of revision Tommy John surgery is substantially higher than previously reported. For MLB pitchers, return to play after revision surgery is much lower than after primary reconstruction. The overall durability of MLB pitchers after revision ulnar collateral ligament reconstruction decreases significantly compared with controls matched for age and matched controls. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Sleep problems in cancer patients: prevalence and association with distress and pain.

PubMed

Sharma, Neelom; Hansen, Christian Holm; O'Connor, Mark; Thekkumpurath, Parvez; Walker, Jane; Kleiboer, Annet; Murray, Gordon; Espie, Colin; Storey, Dawn; Sharpe, Michael; Fleming, Leanne

2012-09-01

Although it is increasingly recognized that cancer patients often have sleep problems, we lack data on their prevalence and associations in representative clinical populations. We aimed to determine (i) the prevalence of sleep problems amongst outpatients of a cancer centre and (ii) the association with medical variables, emotional distress and pain. Secondary analysis of self-report and medical data on 2862 cancer centre outpatients. Sleep problems were identified using the sleep item from the Patient Health Questionnaire-9: 'Over the last two weeks, how often have you been bothered by trouble falling or staying asleep or sleeping too much?' scored on a four-point frequency scale. Emotional distress was measured using the Hospital Anxiety and Depression Scale and pain using the subscale of the European Organisation for Research and Treatment of Cancer Quality of Life Core 30 questionnaire. Medical data were obtained from the cancer centre clinical database. Sleep problems (bothered more than half the days during the previous 2 weeks) were reported by 30.2% (865/2862, 95% CI = 28.5 to 31.9) of the patients. They were common in both patients with active cancer (34.5%) and in cancer survivors (28.0%). There was only a modest association with cancer site and treatment status, but there was a strong association with pain (odds ratio = 2.7, 95% CI = 2.2 to 3.4) and emotional distress (odds ratio = 4.5, 95% CI = 3.7 to 5.6). Sleep problems are common in cancer outpatients and are strongly associated with pain and emotional distress. A combined approach to the management of sleep, pain and emotional distress is indicated. Copyright © 2011 John Wiley & Sons, Ltd. Copyright © 2011 John Wiley & Sons, Ltd.

Consumer involvement in cancer research: example from a Cancer Network.

PubMed

Arain, Mubashir; Pyne, Sarah; Thornton, Nigel; Palmer, Susan; Sharma, Ricky A

2015-10-01

The involvement of consumers and the general public in improving cancer services is an important component of health services. However, consumer involvement in cancer research is relatively unexplored. The objective of this study was to explore different ways of involving consumers in cancer research in one regional network. Thames Valley Cancer Network Consumer Research Partnership (CRP) group was formed in 2009. The group consists of consumers and professionals to help in promoting consumer involvement in Cancer Research in the Thames Valley. This study evaluated the project of consumer involvement in cancer research in the Thames Valley from March 2010 to March 2011. We used different indices to judge the level of consumer involvement: number of projects involving consumers through the group, types of projects, level of involvement (ranged from consultation on research documents to collaborating in preparing grant applications) and the methods of involving consumers in cancer research. Fifteen projects were submitted to the CRP group during the 12-month period studied. Of these, eight projects were clinical trials, three were qualitative research projects, two were patients' surveys and two were non-randomized interventional studies. Seven projects requested consumer involvement on patient information sheets for clinical trials. Of these seven applications, three also requested consumers' help in designing research questionnaires and another three requested that consumers should be involved in their project management group. In addition, four projects involved consumers in the proposal development phase and another four projects asked for advice on how to increase trial recruitment, conduct patient interviews or help with grant applications. The creation of the CRP and this audit of its activity have documented consumer involvement in cancer research in the Thames Valley. We have clearly shown that consumers can be involved in designing and managing cancer

Press Site Auditorium dedicated to John Holliman

NASA Technical Reports Server (NTRS)

1999-01-01

A ceremony dedicated the KSC Press Site auditorium as the John Holliman Auditorium to honor the correspondent for his enthusiastic, dedicated coverage of America's space program. The auditorium was built in 1980 and has been the focal point for new coverage of Space Shuttle launches. The ceremony followed the 94th launch of a Space Shuttle, on mission STS-96, earlier this morning.

The Life and Work of John Snow

ERIC Educational Resources Information Center

Melville, Wayne; Fazio, Xavier

2007-01-01

Due to his work to determine how cholera was spread in the 18th century, John Snow (1813-1858) has been hailed as the father of modern epidemiology. This article presents an inquiry model based on his life and work, which teachers can use to develop a series of biology lessons involving the history and nature of science. The lessons presented use…

Communication and technology in genetic counseling for familial cancer.

PubMed

Lynch, H T; Snyder, C; Stacey, M; Olson, B; Peterson, S K; Buxbaum, S; Shaw, T; Lynch, P M

2014-03-01

When a cancer predisposing germline mutation is detected in an index case, the presence of the underlying syndrome is confirmed and the potential for predictive testing of at-risk relatives is established. However, the reporting of a positive family history does not routinely lead to communication of information about risk to close, much less distant relatives. This review summarizes information technology utilized to address penetration or 'reach' of knowledge of risk within extended families, including the use of telephone and video counseling to reach distant patients, and anticipate novel internet-based processes for communication between investigators and relatives. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The Population Burden of Cancer: Research Driven by the Catchment Area of a Cancer Center.

PubMed

Tai, Caroline G; Hiatt, Robert A

2017-01-01

Cancer centers, particularly those supported by the National Cancer Institute, are charged with reducing the cancer burden in their catchment area. However, methods to define both the catchment area and the cancer burden are diverse and range in complexity often based on data availability, staff resources, or confusion about what is required. This article presents a review of the current literature identifying 4 studies that have defined various aspects of the cancer burden in a defined geographical area and highlights examples of how some cancer centers and other health institutions have defined their catchment area and characterized the cancer burden within it. We then present a detailed case study of an approach applied by the University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center to define its catchment area and its population cancer burden. We cite examples of how the Cancer Center research portfolio addresses the defined cancer burden. Our case study outlines a systematic approach to using publicly available data, such as cancer registry data, that are accessible by all cancer centers. By identifying gaps and formulating future research directions based on the needs of the population within the catchment area, epidemiologic studies and other types of cancer research can be directed to the population served. This review can help guide cancer centers in developing an approach to defining their own catchment area as mandated and applying research findings to this defined population. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.

PubMed

Llamas-Velasco, Mar; Pérez-Gónzalez, Yosmar C; Daudén, Esteban; Rütten, Arno

2018-05-01

Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer. We retrieved 14 cases with PCACC (each from a different patient) from the files of the authors. Cases were dated from 1994 to 2014. We also evaluated 6 cases of cutaneous breast cancer metastasis RESULTS: No PCACCs expressed GATA3. Breast cancer metastases expressed GATA3 in 100% of our studied cases. Even though GATA3 expression has been reported in many benign and malignant adnexal tumors (mostly of sebaceous, follicular, and apocrine differentiation), as well as in many other neoplasms, GATA3 staining to differentiate PCACC from skin breast cancer metastasis has a high negative predictive value. A positive GATA3 staining in this context should permit one to rule out PCACC with a high level of confidence. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A tribute to John Gibbon.

PubMed

Church, Russell M.

2002-04-28

This article provides an overview of the published research of John Gibbon. It describes his experimental research on scalar timing and his development of scalar timing theory. It also describes his methods of research which included mathematical analysis, conditioning methods, psychophysical methods and secondary data analysis. Finally, it describes his application of scalar timing theory to avoidance and punishment, autoshaping, temporal perception and timed behavior, foraging, circadian rhythms, human timing, and the effect of drugs on timed perception and timed performance of Parkinson's patients. The research of Gibbon has shown the essential role of timing in perception, classical conditioning, instrumental learning, behavior in natural environments and in neuropsychology.

Astronaut John Glenn dons space suit during preflight operations

NASA Technical Reports Server (NTRS)

1964-01-01

Astronaut John Glenn dons space suit during preflight operations at Cape Canaveral, February 20, 1962, the day he flew his Mercury-Atlas 6 spacecraft, Friendship 7, into orbital flight around the Earth.

Thyroid Hormone, Cancer, and Apoptosis.

PubMed

Lin, Hung-Yun; Chin, Yu-Tan; Yang, Yu-Chen S H; Lai, Husan-Yu; Wang-Peng, Jacqueline; Liu, Leory F; Tang, Heng-Yuan; Davis, Paul J

2016-06-13

Thyroid hormones play important roles in regulating normal metabolism, development, and growth. They also stimulate cancer cell proliferation. Their metabolic and developmental effects and growth effects in normal tissues are mediated primarily by nuclear hormone receptors. A cell surface receptor for the hormone on integrin [alpha]vβ3 is the initiation site for effects on tumor cells. Clinical hypothyroidism may retard cancer growth, and hyperthyroidism was recently linked to the prevalence of certain cancers. Local levels of thyroid hormones are controlled through activation and deactivation of iodothyronine deiodinases in different organs. The relative activities of different deiodinases that exist in tissues or organs also affect the progression and development of specific types of cancers. In this review, the effects of thyroid hormone on signaling pathways in breast, brain, liver, thyroid, and colon cancers are discussed. The importance of nuclear thyroid hormone receptor isoforms and of the hormone receptor on the extracellular domain of integrin [alpha]vβ3 as potential cancer risk factors and therapeutic targets are addressed. We analyze the intracellular signaling pathways activated by thyroid hormones in cancer progression in hyperthyroidism or at physiological concentrations in the euthyroid state. Determining how to utilize the deaminated thyroid hormone analog (tetrac), and its nanoparticulate derivative to reduce risks of cancer progression, enhance therapeutic outcomes, and prevent cancer recurrence is also deliberated. © 2016 American Physiological Society. Compr Physiol 6:1221-1237, 2016. Copyright © 2016 John Wiley & Sons, Inc.

John Day River Sub-Basin Fish Habitat Enhancement Project; 2008 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Powell, Russ M.; Alley, Pamela D.; Goin Jr, Lonnie

Work undertaken in 2008 included: (1) Seven new fence projects were completed thereby protecting approximately 10.97 miles of streams with 16.34 miles of riparian fence; (2) Renewal of one expired lease was completed thereby continuing to protect 0.75 miles of stream with 1.0 mile of riparian fence. (3) Maintenance of all active project fences (106.54 miles), watergaps (78), spring developments (33) were checked and repairs performed; (3) Planted 1000 willow/red osier on Fox Creek/Henslee property; (4) Planted 2000 willows/red osier on Middle Fork John Day River/Coleman property; (5) Planted 1000 willow/red osier cuttings on Fox Creek/Johns property; (6) Since themore » initiation of the Fish Habitat Project in 1984 we have 126.86 miles of stream protected using 211.72 miles of fence protecting 5658 acres. The purpose of the John Day Fish Habitat Enhancement Program is to enhance production of indigenous wild stocks of spring Chinook and summer steelhead within the sub basin through habitat protection, enhancement and fish passage improvement. The John Day River system supports the largest remaining wild runs of spring chinook salmon and summer steelhead in Northeast Oregon.« less

Cancer treatment decision-making among young adults with lung and colorectal cancer: a comparison with adults in middle age.

PubMed

Mack, Jennifer W; Cronin, Angel; Fasciano, Karen; Block, Susan D; Keating, Nancy L

2016-09-01

Our aim is to understand experiences with treatment decision-making among young adults with cancer. We studied patients with lung cancer or colorectal cancer in the Cancer Care Outcomes Research and Surveillance Consortium, a prospective cohort study. We identified 148 young adult patients aged 21-40 years who completed baseline interview questions about cancer treatment decision-making; each was propensity score matched to three middle adult patients aged 41-60 years, for a cohort of 592 patients. Patients were asked about decision-making preferences, family involvement in decision-making, and worries about treatment. An ordinal logistic regression model evaluated factors associated with more treatment worries. Young and middle-aged adults reported similar decision-making preferences (p = 0.80) and roles relative to physicians (p = 0.36). Although family involvement was similar in the age groups (p = 0.21), young adults were more likely to have dependent children in the home (60% younger versus 28% middle-aged adults, p < 0.001). Young adults reported more worries about time away from family (p = 0.002), and, in unadjusted analyses, more cancer treatment-related worries (mean number of responses of 'somewhat' or 'very' worried 2.5 for younger versus 2.2 for middle-aged adults, p = 0.02.) However, in adjusted analyses, worries were associated with the presence of dependent children in the home (odds ratio [OR] 1.55, 95% CI = 1.07-2.24, p = 0.02), rather than age. Young adults involve doctors and family members in decisions at rates similar to middle-aged adults but experience more worries about time away from family. Patients with dependent children are especially likely to experience worries. Treatment decision-making strategies should be based on individual preferences and needs rather than age alone. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Indigenous Australians with non-small cell lung cancer or cervical cancer receive suboptimal treatment.

PubMed

Whop, Lisa J; Bernardes, Christina M; Kondalsamy-Chennakesavan, Srinivas; Darshan, Deepak; Chetty, Naven; Moore, Suzanne P; Garvey, Gail; Walpole, Euan; Baade, Peter; Valery, Patricia C

2017-10-01

Lung cancer and cervical cancer are higher in incidence for Indigenous Australians and survival is worse compared with non-Indigenous Australians. Here we aim to determine if being Indigenous and/or other factors are associated with patients receiving "suboptimal treatment" compared to "optimal treatment" according to clinical guidelines for two cancer types. Data were collected from hospital medical records for Indigenous adults diagnosed with cervical cancer and non-small cell lung cancer (NSCLC) and a frequency-matched comparison group of non-Indigenous patients in the Queensland Cancer Registry between January 1998 and December 2004. The two cancer types were analyzed separately. A total of 105 women with cervical cancer were included in the study, 56 of whom were Indigenous. Indigenous women had higher odds of not receiving optimal treatment according to clinical guidelines (unadjusted OR 7.1; 95% CI, 1.5-33.3), even after adjusting for stage (OR 5.7; 95% CI, 1.2-27.3). Of 225 patients with NSCLC, 198 patients (56% Indigenous) had sufficient information available to be analyzed. The odds of receiving suboptimal treatment were significantly higher for Indigenous compared to non-Indigenous NSCLC patients (unadjusted OR 1.9; 95% CI, 1.0-3.6) and remained significant after adjusting for stage, comorbidity and age (adjusted OR 2.1; 95% CI, 1.1-4.1). The monitoring of treatment patterns and appraisal against guidelines can provide valuable evidence of inequity in cancer treatment. We found that Indigenous people with lung cancer or cervical cancer received suboptimal treatment, reinforcing the need for urgent action to reduce the impact of these two cancer types on Indigenous people. © 2016 John Wiley & Sons Australia, Ltd.

The Inner Child and Other Conceptualizations of John Bradshaw.

ERIC Educational Resources Information Center

Bordan, Terry

1994-01-01

Interviewed John Bradshaw on radio talk show. Bradshaw contributed to a greater understanding of factors that foster and maintain substance abuse and dysfunctional families. Focused on his concept of the inner child. (JBJ)

76 FR 67206 - Notice of Public Meeting, John Day-Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-31

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLORV00000.L10200000.DD0000; HAG 12-0022] Notice of Public Meeting, John Day-Snake Resource Advisory Council AGENCY: Bureau of Land Management... (BLM) John Day-Snake Resource Advisory Council (RAC) will meet as indicated below: DATES: The meeting...

76 FR 78691 - Notice of Public Meeting, John Day-Snake Resource Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLORV00000.L10200000.DD0000; HAG 12-0056] Notice of Public Meeting, John Day-Snake Resource Advisory Council AGENCY: Bureau of Land Management... (BLM) John Day-Snake Resource Advisory Council (RAC) will meet as indicated below: DATES: The meeting...

Clinical value of integrated-signature miRNAs in esophageal cancer.

PubMed

Zhang, Heng-Chao; Tang, Kai-Fu

2017-08-01

MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated-miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa-miR-100-5p and hsa-miR-133b) show better prognoses with significant difference for both 3-year and 5-year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

46 CFR 7.95 - St. Johns Point, FL to Miami Beach, FL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false St. Johns Point, FL to Miami Beach, FL. 7.95 Section 7... LINES Atlantic Coast § 7.95 St. Johns Point, FL to Miami Beach, FL. (a) A line drawn from the seaward extremity of St. Augustine Inlet north jetty to latitude 29°55′ N. longitude 81°15.3′ W. (St. Augustine...

Increased incidence of another cancer in myeloproliferative neoplasms patients at the time of diagnosis.

PubMed

Pettersson, Helna; Knutsen, Håvar; Holmberg, Erik; Andréasson, Björn

2015-02-01

Several studies have reported an increased incidence of coexistent cancer in patients with myeloproliferative neoplasms (MPN), and myelosuppressive treatment has been speculated to be one of the causes. In this study, we have concentrated on malignancies diagnosed before the MPN diagnosis to eliminate the possible influence of MPN treatment. The patients were recruited from the Swedish and Norwegian cancer registries. One thousand seven hundred and 45 patients from the Swedish MPN Quality Registry and 468 patients from the Norwegian National Cancer Registry were included in this study covering a 3-yr period. The results show that primary concurrent cancer is higher among patients with MPN compared to the general population. When pooled together, the Swedish and the Norwegian cohort showed increased prevalence of all types of cancer in general compared with the general population, standard prevalence ratio (SPR) of 1.20 (95% CI 1.07-1.34). Significantly high SPRs were reached for skin malignant melanoma [1.89 (95% CI 1.33-2.62)], prostate cancer [1.39 (95% CI 1.11-1.71)], and hematologic cancer [1.49 (95% CI 1.00-2.12)]. In the polycythemia vera group, the risk of having prior malignant melanoma of the skin was significant, with an SPR of 2.20 (95% CI 1.17-3.77). For patients with essential thrombocythemia and primary myelofibrosis, no significant risks were found. Coexisting cancers have a high impact on the treatment strategies of MPN, as it narrows down the treatment options. Chronic inflammation, as a common denominator of MPN with other cancers, can catalyze each other's existence and progression. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

A Global Cancer Surveillance Framework Within Noncommunicable Disease Surveillance: Making the Case for Population-Based Cancer Registries.

PubMed

Piñeros, Marion; Znaor, Ariana; Mery, Les; Bray, Freddie

2017-01-01

The growing burden of cancer among several major noncommunicable diseases (NCDs) requires national implementation of tailored public health surveillance. For many emerging economies where emphasis has traditionally been placed on the surveillance of communicable diseases, it is critical to understand the specificities of NCD surveillance and, within it, of cancer surveillance. We propose a general framework for cancer surveillance that permits monitoring the core components of cancer control. We examine communalities in approaches to the surveillance of other major NCDs as well as communicable diseases, illustrating key differences in the function, coverage, and reporting in each system. Although risk factor surveys and vital statistics registration are the foundation of surveillance of NCDs, population-based cancer registries play a unique fundamental role specific to cancer surveillance, providing indicators of population-based incidence and survival. With an onus now placed on governments to collect these data as part of the monitoring of NCD targets, the integration of cancer registries into existing and future NCD surveillance strategies is a vital requirement in all countries worldwide. The Global Initiative for Cancer Registry Development, endorsed by the World Health Organization, provides a means to enhance cancer surveillance capacity in low- and middle-income countries. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Interview with Antony John Kunnan on Language Assessment

ERIC Educational Resources Information Center

Nimehchisalem, Vahid

2015-01-01

Antony John Kunnan is a language assessment specialist. His research interests are fairness of tests and testing practice, assessment literacy, research methods and statistics, ethics and standards, and language assessment policy. His most recent publications include a four-volume edited collection of 140 chapters titled "The Companion to…

Astronaut John Glenn, Jr. - Insertion - Mercury Spacecraft - Cape

NASA Image and Video Library

1962-02-20

S62-00371 (20 Feb. 1962) --- Mercury astronaut John H. Glenn Jr., pilot of the Mercury-Atlas 6 (MA-6) spaceflight, enters the Mercury "Friendship 7" spacecraft during the MA-6 prelaunch preparations at Cape Canaveral, Florida. Glenn became the first American to orbit Earth. Photo credit: NASA

Some Thoughts on John Dewey's Ethics and Education

ERIC Educational Resources Information Center

Karafillis, Gregorios

2012-01-01

The philosopher and educator, John Dewey, explores the emergence of the terms "ethics" and "education" from a pragmatist's perspective, i.e., within the linguistic and social components' framework, and society's existing cognitive and cultural level. In the current article, we examine the development, logical control and the relation between…

John Dewey's Democracy and Education: A British Tribute

ERIC Educational Resources Information Center

Higgins, Steve, Ed.; Coffield, Frank, Ed.

2016-01-01

In 1916 John Dewey published "Democracy and Education: An introduction to the philosophy of education". In this book some of today's foremost historians, philosophers, psychologists, and sociologists of education mark the anniversary of Dewey's work by reviewing and reflecting, from a British perspective, on Dewey's contribution to our…

How to Write About a Bumblebee--John Burroughs.

ERIC Educational Resources Information Center

Stock, Tom

1981-01-01

The personal comments of literary naturalist, John Burroughs, whose 60-year writing career began in the 1860s, can guide writing teachers today. Recommended techniques include literary walks, a fermentation process between contact with nature and writing about it, emphasis on clarity and truth, and keeping a journal. (NEC)

From Diagnosis, to Life Saving Therapy, to Hollywood: The Journey of John Crowley

ERIC Educational Resources Information Center

Apel, Laura

2010-01-01

In February of 2000, "Exceptional Parent" introduced readers to the Crowley family. The author profiled John, Aileen, and their three children: Megan, Patrick, and John Jr. They told "Exceptional Parent" that in 1998 both Megan and Patrick were diagnosed with Pompe disease, a progressive, multisystemic, debilitating, and often fatal muscular…

Cancer-related information needs and cancer's impact on control over life influence health-related quality of life among adolescents and young adults with cancer.

PubMed

DeRouen, Mindy C; Smith, Ashley Wilder; Tao, Li; Bellizzi, Keith M; Lynch, Charles F; Parsons, Helen M; Kent, Erin E; Keegan, Theresa H M

2015-09-01

Adolescents and young adults (AYAs) diagnosed with cancer between 15 and 39 years of age often report need for greater amounts of cancer-related information and perceive that cancer has had a negative impact on control over their life. We examined whether unmet information need and perceived control over life are associated with health-related quality of life (HRQOL). We examined data from 484 AYA cancer survivors recruited from population-based cancer registries in 2007-2008. Participants completed surveys a median of 11 months after diagnosis. Multivariable linear regression analyses estimated associations of unmet cancer-related information needs and impact of cancer on control over life on HRQOL (SF-12). Two-thirds of AYAs reported an intermediate or high level of unmet information need, and half (47%) reported a negative impact of cancer on control. Greater unmet information need was associated with lower overall mental and physical HRQOL and lower levels of all HRQOL subscales except vitality. A negative impact on control over life was associated with lower overall mental HRQOL as well as lower HRQOL across all subscales except general health perceptions (all p <0.05). In multivariable analyses, perceived control and unmet information need were independently associated with HRQOL (p-values for interaction >0.1). Adolescent and young adult patients with cancer have high levels of unmet cancer-related information needs and perceived negative impact of cancer on control over life; both were independently associated with lower HRQOL. Addressing unmet information needs among AYA cancer survivors and finding ways to increase their sense of control may help improve HRQOL in this understudied population. Copyright © 2015 John Wiley & Sons, Ltd.

Unit 4, upstream from Johns Street Bridge Johnstown Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Unit 4, upstream from Johns Street Bridge - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

Unit 4, downstream from Johns Street Bridge Johnstown Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Unit 4, downstream from Johns Street Bridge - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

John H Glenn Jr. Receives Presidential Medal of Freedom

NASA Image and Video Library

2012-05-29

President Barack Obama presents former United States Marine Corps pilot, astronaut and United States Senator John Glenn with a Medal of Freedom, Tuesday, May 29, 2012, during a ceremony at the White House in Washington.

3. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY PHOTOGRAPHER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY - PHOTOGRAPHER - MARCH 16, 1934 INTERIOR SHOWING SOUTH TRUSS - Whitewater Canal Aqueduct, Spanning Duck Creek, Whitewater Canal (carried over creek) (Changed from Duck Creek), Metamora, Franklin County, IN

2. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY PHOTOGRAPHER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY - PHOTOGRAPHER - MARCH 16, 1934 VIEW OF NORTH SIDE - Whitewater Canal Aqueduct, Spanning Duck Creek, Whitewater Canal (carried over creek) (Changed from Duck Creek), Metamora, Franklin County, IN

4. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY PHOTOGRAPHER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY - PHOTOGRAPHER - MARCH 16, 1934 DETAIL OF NORTHWEST CORNER - Whitewater Canal Aqueduct, Spanning Duck Creek, Whitewater Canal (carried over creek) (Changed from Duck Creek), Metamora, Franklin County, IN

1. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY PHOTOGRAPHER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. HISTORIC AMERICAN BUILDINGS SURVEY JOHN R. KELLEY - PHOTOGRAPHER - MARCH 16, 1934 GENERAL VIEW FROM SOUTHWEST - Whitewater Canal Aqueduct, Spanning Duck Creek, Whitewater Canal (carried over creek) (Changed from Duck Creek), Metamora, Franklin County, IN

Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer.

PubMed

Mantere, T; Haanpää, M; Hanenberg, H; Schleutker, J; Kallioniemi, A; Kähkönen, M; Parto, K; Avela, K; Aittomäki, K; von Koskull, H; Hartikainen, J M; Kosma, V-M; Laasanen, S-L; Mannermaa, A; Pylkäs, K; Winqvist, R

2015-07-01

Mutations in downstream Fanconi anemia (FA) pathway genes, BRCA2, PALB2, BRIP1 and RAD51C, explain part of the hereditary breast cancer susceptibility, but the contribution of other FA genes has remained questionable. Due to FA's rarity, the finding of recurrent deleterious FA mutations among breast cancer families is challenging. The use of founder populations, such as the Finns, could provide some advantage in this. Here, we have resolved complementation groups and causative mutations of five FA patients, representing the first mutation confirmed FA cases in Finland. These patients belonged to complementation groups FA-A (n = 3), FA-G (n = 1) and FA-I (n = 1). The prevalence of the six FA causing mutations was then studied in breast (n = 1840) and prostate (n = 565) cancer cohorts, and in matched controls (n = 1176 females, n = 469 males). All mutations were recurrent, but no significant association with cancer susceptibility was observed for any: the prevalence of FANCI c.2957_2969del and c.3041G>A mutations was even highest in healthy males (1.7%). This strengthens the exclusive role of downstream genes in cancer predisposition. From a clinical point of view, current results provide fundamental information of the mutations to be tested first in all suspected FA cases in Finland. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Examining the mediating role of cancer-related problems on spirituality and self-rated health among African American cancer survivors: a report from the American Cancer Society's Studies of Cancer Survivors-II.

PubMed

Best, Alicia L; Alcaraz, Kassandra I; McQueen, Amy; Cooper, Dexter L; Warren, Rueben C; Stein, Kevin

2015-09-01

African American (AA) cancer survivors report poorer self-rated health (SRH) compared to other racial/ethnic groups. Spirituality is often linked to positive health outcomes, with AAs reporting greater levels of spirituality. This study examined the potential mediating role of cancer-related problems in the relationship between spirituality and SRH among AA cancer survivors compared to non-African American (non-AA) survivors. We analyzed data on 9006 adult cancer survivors from the American Cancer Society's Study of Cancer Survivors-II. Preliminary analyses compared characteristics of AAs and non-AAs and identified significant covariates of SRH. We tested a path model using multi-group structural equation modeling (SEM), and then examined race as a moderator. Of the three domains of spirituality assessed, AAs had higher levels of peace (p < .001) and faith (p < .001), but not meaning, compared to non-AAs; and of four domains of cancer-related problems assessed, AAs had greater physical distress (p < .001), emotional distress (p < .001), and employment/finance problems (p < .001), but not fear of recurrence. In SEM analyses adjusting for number of comorbidities and income, race moderated the impact of spirituality and cancer-related problems on SRH. Specifically, spirituality had significantly stronger associations with cancer-related problems among AAs than non-AAs. Spirituality was positively associated with all four domains of cancer-related problems, but only physical distress was associated with SRH among AAs. The negative effects of physical distress may attenuate the positive effects of spirituality on AA's SRH. Future studies should consider racial/ethnic differences in the determinants and conceptualization of SRH, which is a known predictor of survival. Copyright © 2014 John Wiley & Sons, Ltd.

Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.

PubMed

Allison, Katrina E; Coomber, Brenda L; Bridle, Byram W

2017-10-01

Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to glycolysis and up-regulating glutaminolysis to divert carbon sources into biosynthetic pathways that promote proliferation and survival. Therefore, metabolic inhibitors represent promising anti-cancer drugs. However, T cells must rapidly divide and survive in harsh microenvironments to mediate anti-cancer effects. Metabolic profiles of cancer cells and activated T lymphocytes are similar, raising the risk of metabolic inhibitors impairing the immune system. Immune checkpoint blockade provides an example of how metabolism can be differentially impacted to impair cancer cells but support T cells. Implications for research with metabolic inhibitors are discussed. © 2017 John Wiley & Sons Ltd.

A Reply to John Searle and Other Traditionalists

ERIC Educational Resources Information Center

Brice, Robert Greenleaf

2008-01-01

In an article entitled "Traditionalists & Their Challengers," John Searle says there is "supposed to be a major debate" in the universities as to whether liberal education should be replaced with multiculturalism. He finds this debate "puzzling," "disappointing," even "depressing." By dividing academia into two groups, the so-called "defenders of…

STS-79 Mission Specialist John Blaha in White Room

NASA Technical Reports Server (NTRS)

1996-01-01

STS-79 Mission Specialist John E. Blaha shares a light moment with white room closeout crew members Rick Welty (No. 1) and Jim Davis (right), before entering the Space Shuttle Atlantis at Launch Pad 39A.

John A. Simpson (1916-2000)

NASA Astrophysics Data System (ADS)

Jokipii, J. R.; Gloeckler, G.

John Alexander Simpson, a long-time member and Fellow of AGU, member of the National Academy of Sciences, and last year's recipient of the Bowie Medal, died on August 31, 2000, from complications following open heart surgery. He was 83 years old and a professor emeritus at the University of Chicago, where he spent most of an extraordinarily varied and productive career.He received his bachelor's degree from Reed College in 1940, and a master's and a doctorate from New York University in 1942 and 1943. After working on the Manhattan Project until 1946, he joined the University of Chicago faculty where he rose through the ranks and was appointed to a succession of prestigious named professorships.

Handgrip and knee extension strength as predictors of cancer mortality: A systematic review and meta-analysis.

PubMed

García-Hermoso, A; Ramírez-Vélez, R; Peterson, M D; Lobelo, F; Cavero-Redondo, I; Correa-Bautista, J E; Martínez-Vizcaíno, V

2018-05-03

The specific role of different strength measures on mortality risk needs to be clarified to gain a better understanding of the clinical importance of different muscle groups, as well as to inform intervention protocols in relation to reducing early mortality. The aim of the systematic review and meta-analysis was to determine the relationship between muscular strength and risk of cancer mortality. Eligible cohort studies were those that examined the association between muscular strength, as assessed using validated tests, and cancer mortality in healthy youth and adults. The hazard ratio (HR) estimates obtained were pooled using random effects meta-analysis models. The outcome was cancer mortality assessed using the HR (Cox proportional hazards model). Eleven prospective studies with 1 309 413 participants were included, and 9787 cancer-specific deaths were reported. Overall, greater handgrip (HR = 0.97, 95% CI, 0.92-1.02; P = .055; I 2  = 18.9%) and knee extension strength (HR = 0.98, 95% CI, 0.95-1.00; P = .051; I 2  = 60.6%) were barely significant associated with reduced risk of cancer mortality. Our study suggests that higher level of muscular strength is not statistically associated with lower risk of cancer mortality. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

John Hughlings-Jackson: a sesquicentennial tribute.

PubMed

Swash, M

1986-09-01

One hundred and fifty years have elapsed since the birth of John Hughlings-Jackson, a pivotal figure in the development of clinical neuroscience. In this review the origin of Jackson's postulate of a hierarchical organisation of function in the nervous system is described in the context of his education and his contacts with contemporaries, both in his clinical practice at The London Hospital and at the National Hospital, Queen Square, and in relation to the evolutionary approach to the organisation and ideas on biology and society set out by the philosopher Herbert Spencer.

DNA origami applications in cancer therapy.

PubMed

Udomprasert, Anuttara; Kangsamaksin, Thaned

2017-08-01

Due to the complexity and heterogeneity of cancer, the development of cancer diagnosis and therapy is still progressing, and a complete understanding of cancer biology remains elusive. Recently, cancer nanomedicine has gained much interest as a promising diagnostic and therapeutic strategy, as a wide range of nanomaterials possess unique physical properties that can render drug delivery systems safer and more effective. Also, targeted drug delivery and precision medicine have now become a new paradigm in cancer therapy. With nanocarriers, chemotherapeutic drugs could be directly delivered into target cancer cells, resulting in enhanced efficiency with fewer side-effects. DNA, a biomolecule with molecular self-assembly properties, has emerged as a versatile nanomaterial to construct multifunctional platforms; DNA nanostructures can be modified with functional groups to improve their utilities as biosensors or drug carriers. Such applications have become possible with the advent of the scaffolded DNA origami method. This breakthrough technique in structural DNA nanotechnology provides an easier and faster way to construct DNA nanostructures with various shapes. Several experiments proved that DNA origami nanostructures possess abilities to enhance efficacies of chemotherapy, reduce adverse side-effects, and even circumvent drug resistance. Here, we highlight the principles of the DNA origami technique and its applications in cancer therapeutics and discuss current challenges and opportunities to improve cancer detection and targeted drug delivery. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

The Arrest and Vindication of John H. Hickcox

ERIC Educational Resources Information Center

Stimson, Nancy F.; Nobunaga, Wendy Y.

2004-01-01

In January 1882, John H. Hickcox, a central government documents figure in his time, and the creator of "United States Government Publications: A Monthly Catalogue" or "Hickcox's Monthly Catalogue" was arrested in Washington, DC, for taking letters addressed to the Librarian of Congress. Although the charges were eventually dismissed, 1882 is the…

Huang Zongxi's and John Locke's Rhetoric toward Modernity

ERIC Educational Resources Information Center

Wang, Xiaobo

2012-01-01

Huang Zongxi was an influential seventeenth century Chinese political and social theorist who is considered by many to be the inspiration and founding father of democracy and human rights in China. This article examines the many similarities in thought and social influence between Huang and his contemporary, the English philosopher John Locke.…

John Lloyd Stephens and Frederick Catherwood: Mayan Explorers.

ERIC Educational Resources Information Center

McDermott, Michael

This mini-unit focuses on the lives and accomplishments of John Lloyd Stephens and Frederick Catherwood and their contacts with the Maya. This project deals specifically with how Stephens' published accounts and Catherwood's drawings became the basis from which all further Mayan research developed. These two explorers were the first to describe…

Talking with John Trim (Part I): A Career in Phonetics, Applied Linguistics and the Public Service

ERIC Educational Resources Information Center

Little, David; King, Lid

2013-01-01

As this issue was in preparation, the journal learned with great regret of the passing of John Trim. John was a long-serving member of the "Language Teaching" Board and his insight and advice proved invaluable for this and previous editors. An expert in the field of phonetics, linguistics, language didactics and policy, John worked…

Curiosity Rover Self Portrait at John Klein Drilling Site

NASA Image and Video Library

2013-02-07

The rover is positioned at a patch of flat outcrop called John Klein, which was selected as the site for the first rock-drilling activities by NASA Curiosity. This self-portrait was acquired to document the drilling site.

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses.

PubMed

Garg, Abhishek D; Agostinis, Patrizia

2017-11-01

The immunogenicity of cancer cells is an emerging determinant of anti-cancer immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell-based vaccines, immune-checkpoint blockers, and adoptive T-cell transfer, investigators are beginning to focus on the immunobiology of dying cancer cells and its relevance for the success of anticancer immunotherapies. It is currently accepted that cancer cells may die in response to anti-cancer therapies through regulated cell death programs, which may either repress or increase their immunogenic potential. In particular, the induction of immunogenic cancer cell death (ICD), which is hallmarked by the emission of damage-associated molecular patterns (DAMPs); molecules analogous to pathogen-associated molecular patterns (PAMPs) acting as danger signals/alarmins, is of great relevance in cancer therapy. These ICD-associated danger signals favor immunomodulatory responses that lead to tumor-associated antigens (TAAs)-directed T-cell immunity, which paves way for the removal of residual, treatment-resistant cancer cells. It is also emerging that cancer cells succumbing to ICD can orchestrate "altered-self mimicry" i.e. mimicry of pathogen defense responses, on the levels of nucleic acids and/or chemokines (resulting in type I interferon/IFN responses or pathogen response-like neutrophil activity). In this review, we exhaustively describe the main molecular, immunological, preclinical, and clinical aspects of immunosuppressive cell death or ICD (with respect to apoptosis, necrosis and necroptosis). We also provide an extensive historical background of these fields, with special attention to the self/non-self and danger models, which have shaped the field of cell death immunology. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Managing Cancer Care: a psycho-educational intervention to improve knowledge of care options and breast cancer self-management.

PubMed

Schulman-Green, Dena; Jeon, Sangchoon

2017-02-01

We tested the feasibility and acceptability of a psycho-educational self-management intervention, Managing Cancer Care: A Personal Guide (MCC), to improve knowledge of care options (curative, palliative, and hospice care) among a range of breast cancer self-management skills. We conducted a one-group, pre-post-test study among women with non-metastatic breast cancer (n = 105). We gave participants the printed, self-guided, seven-module intervention following enrollment. At baseline and 2  months, we measured knowledge of care options, desired and actual role in self-management, medical communication skills, experience and management of transitions, anxiety, depression, uncertainty, and self-efficacy. We conducted interviews to obtain module ratings and qualitative data on strengths and limitations of MCC. Knowledge of care options (δ = 0.40 (1.11), p = 0.0005) and desired role in self-management (δ = -0.28 (1.08), p = 0.0177) significantly improved. Less skilled medical communicators significantly improved their communication (δ = 3.47, standard deviation = 6.58, p = 0.0449). Multivariate modeling showed that changes in our primary outcomes of medical communication and management of transitions seemed to drive positive changes in our secondary outcomes of anxiety, depression, uncertainty, and self-efficacy. Participants highly rated MCC and reported the importance of understanding care options despite non-metastatic disease. MCC is a feasible and acceptable means of improving knowledge of care options and other aspects of breast cancer self-management. The combination of modules offered in MCC appears to have beneficial interactive effects. We are currently testing MCC more rigorously in a randomized controlled trial to explore mediating and moderating relationships. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Cecilia John: An Australian Heads the London School of Dalcroze Eurhythmics, 1932-1955

ERIC Educational Resources Information Center

Pope, Joan

2014-01-01

The London School of Dalcroze Eurhythmics (LSDE) was established in 1913, and a significant figure in its history was the remarkable Cecilia John, one of seven Australians to complete the three-year course between 1917 and 1927. Apart from two short visits to Australia, John lived and taught in England for the remainder of her life. Following the…

John Bowlby and ethology: an annotated interview with Robert Hinde.

PubMed

Bowlby, John

2007-12-01

From the 1950s, John Bowlby, one of the founders of attachment theory, was in personal and scientific contact with leading European scientists in the field of ethology (e.g., Niko Tinbergen, Konrad Lorenz, and especially Robert Hinde). In constructing his new theory on the nature of the bond between children and their caregivers, Bowlby profited highly from their new approach to (animal) behavior. Hinde and Tinbergen in their turn were influenced and inspired by Bowlby's new thinking. On the basis of extensive interviews with bowlby's colleague and lifelong friend Robert Hinde and on the basis of archival materials, both the relationship between John Bowlby and Robert Hinde and the cross-fertilization of ethology and attachment theory are described.

Aboriginal experiences of cancer and care coordination: Lessons from the Cancer Data and Aboriginal Disparities (CanDAD) narratives.

PubMed

Reilly, Rachel; Micklem, Jasmine; Yerrell, Paul; Banham, David; Morey, Kim; Stajic, Janet; Eckert, Marion; Lawrence, Monica; Stewart, Harold B; Brown, Alex

2018-04-24

Aboriginal people with cancer experience worse outcomes than other Australians for a range of complex and interrelated reasons. A younger age at diagnosis, higher likelihood of more advanced cancer or cancer type with poorer prognosis, geographic isolation and cultural and language diversity mean that patient pathways are potentially more complex for Aboriginal people with cancer. In addition, variation in the quality and acceptability of care may influence cancer outcomes. This study sought to understand how care coordination influences Aboriginal people's experiences of cancer treatment. Interviews with 29 Aboriginal patients or cancer survivors, 11 carers and 22 service providers were carried out. Interviews were semi-structured and sought to elicit experiences of cancer and the health-care system. The manifest content of the cancer narratives was entered onto a cancer pathway mapping tool and underlying themes were identified inductively. The practice of cancer care coordination was found to address the needs of Aboriginal patients and their families/carers in 4 main areas: "navigating the health system"; "information and communication"; "things to manage at home"; and "cultural safety". The CanDAD findings indicate that, when the need for cancer care coordination is met, it facilitated continuity of care in a range of ways that may potentially improve cancer outcomes. However, the need remains unmet for many. Findings support the importance of dedicated care coordination to enable Aboriginal people to receive adequate and appropriate patient-centred care, so that the unacceptable disparity in cancer outcomes between Aboriginal and non-Aboriginal people can be addressed. © 2018 The Authors. Health Expectations published by John Wiley & Sons Ltd.

Clopidogrel use and cancer-specific mortality: a population-based cohort study of colorectal, breast and prostate cancer patients.

PubMed

Hicks, Blánaid M; Murray, Liam J; Hughes, Carmel; Cardwell, Chris R

2015-08-01

Concerns were raised about the safety of antiplatelet thienopyridine derivatives after a randomized control trial reported increased risks of cancer and cancer deaths in prasugrel users. We investigate whether clopidogrel, a widely used thienopyridine derivative, was associated with increased risk of cancer-specific or all-cause mortality in cancer patients. Colorectal, breast and prostate cancer patients, newly diagnosed from 1998 to 2009, were identified from the National Cancer Data Repository. Cohorts were linked to the UK Clinical Practice Research Datalink, providing prescription records, and to the Office of National Statistics mortality data (up to 2012). Unadjusted and adjusted hazard ratios (HRs) for cancer-specific and all-cause mortality in post-diagnostic clopidogrel users were calculated using time-dependent Cox regression models. The analysis included 10 359 colorectal, 17 889 breast and 13 155 prostate cancer patients. There was no evidence of an increase in cancer-specific mortality in clopidogrel users with colorectal (HR = 0.98 95% confidence interval (CI) 0.77, 1.24) or prostate cancer (HR = 1.03 95%CI 0.82, 1.28). There was limited evidence of an increase in breast cancer patients (HR = 1.22 95%CI 0.90, 1.65); however, this was attenuated when removing prescriptions in the year prior to death. This novel study of large population-based cohorts of colorectal, breast and prostate cancer patients found no evidence of an increased risk of cancer-specific mortality among colorectal, breast and prostate cancer patients using clopidogrel. Copyright © 2015 John Wiley & Sons, Ltd.

Cancer diagnosis disclosure preferences of family caregivers of cancer patients in Egypt.

PubMed

Alsirafy, Samy A; Abdel-Kareem, Shady S; Ibrahim, Noha Y; Abolkasem, Mohamed A; Farag, Dina E

2017-11-01

Family caregivers (FCs) of cancer patients are frequently seen as a barrier to honest communication with patients in Egypt. This study was conducted to investigate the attitude of FCs of cancer patients toward cancer diagnosis disclosure (CDD) and its determinants. A structured interview was used to assess the preferences of 288 FCs regarding CDD. According to the FCs, 85% of patients were aware of their diagnosis. The majority (81%) of FCs preferred CDD to patients. In case they developed cancer, 92% of FCs wanted to know their diagnosis and 88% wanted to inform their families. In a univariate analysis, factors associated with FCs' negative attitude toward CDD to patients were as follows: patient's lower level of education (P = .001), patient's rural residence (P < .001), hematological malignancies (P < .001), FC's belief that the patient is unaware of diagnosis (P < .001), FC's unwillingness to know his/her own cancer diagnosis (P < .001), and FC's unwillingness to inform his/her family about his/her cancer diagnosis (P < .001). Only 2 factors predicted independently the negative attitude of FCs toward CDD, the FC's belief that the patient is unaware of diagnosis (P < .001), and the FC's unwillingness to know his/her own cancer diagnosis (P = .049). The results suggest that the majority of FCs of Egyptian cancer patients prefer CDD to patients. The finding that the vast majority of FCs of aware patients preferred CDD suggests that the reaction of Egyptian patients to CDD is acceptable by FCs. Family caregivers with a negative attitude toward CDD may be reflecting their own fears. Copyright © 2016 John Wiley & Sons, Ltd.

2011 John M. Eisenberg Patient Safety and Quality Awards.

PubMed

2012-07-01

The 2011 John M. Eisenberg Patient Safety and Quality Awards were presented on April 5, 2012, in Washington, D.C. Individual award recipients were interviewed for this issue, and organization or group award recipients contributed articles describing their work.

John Collier's Crusade for Indian Reform: 1920-1954.

ERIC Educational Resources Information Center

Philp, Kenneth R.

For many years federal government policy sought to break up Indian communal land holdings, destroy tribal communities, and absorb Indians into the mainstream of American Society. This policy changed dramatically in the 1920's and 30's, and John Collier stands at the forefront of those responsible. Collier questioned the wisdom of a policy which…

Justice John Paul Stevens and the Erotic Boomerang.

ERIC Educational Resources Information Center

Lieberman, Marc

Justice John Paul Stevens of the United States Supreme Court has ruled on obscenity cases in seven instances since his appointment. His rulings reveal that he regards obscenity as a nuisance rather than as a danger threatening to undermine the nation's morality, that he supports a nationwide standard to adjudicate obscenity cases, and that he…

Scapegoat: John Dewey and the Character Education Crisis

ERIC Educational Resources Information Center

White, Brian

2015-01-01

Many conservatives, including some conservative scholars, blame the ideas and influence of John Dewey for what has frequently been called a crisis of character, a catastrophic decline in moral behavior in the schools and society of North America. Dewey's critics claim that he is responsible for the undermining of the kinds of instruction that…

Professor John Scott, folate and neural tube defects.

PubMed

Hoffbrand, A Victor

2014-02-01

John Scott (1940-2013) was born in Dublin where he was to spend the rest of his career, both as an undergraduate and subsequently Professor of Biochemistry and Nutrition at Trinity College. His research with the talented group of scientists and clinicians that he led has had a substantial impact on our understanding of folate metabolism, mechanisms of its catabolism and deficiency. His research established the leading theory of folate involvement with vitamin B12 in the pathogenesis of vitamin B12 neuropathy. He helped to establish the normal daily intake of folate and the increased requirements needed either in food or as a supplement before and during pregnancy to prevent neural tube defects. He also suggested a dietary supplement of vitamin B12 before and during pregnancy to reduce the risk of neural tube defects. It would be an appropriate epitaph if fortification of food with folic acid became mandatory in the UK and Ireland, as it is in over 70 other countries. © 2013 John Wiley & Sons Ltd.

Editorial: In defense of science—What would John do?

NASA Astrophysics Data System (ADS)

Gad-el-Hak, Mohamed

2017-02-01

Recent onslaughts on the importance of pure research to our collective well-being are trending. In this essay, I discuss the issues involved and offer a rebuttal. The thoughts are inspired by my mentor, academic sibling, and idol John Leask Lumley.

The Politics of Composition: A Reply to John Rouse.

ERIC Educational Resources Information Center

Graff, Gerald

1980-01-01

Responds to an essay on "the politics of composition" by John Rouse (see EJ 209 264), who interpreted Mina Shaughnessy's teaching strategies as being political conditioning and suppressing student freedoms. Defends Shaughnessy's methods while seeking to refute Rouse's argument. (JT)

Astronaut John Young photographed collecting lunar samples

NASA Technical Reports Server (NTRS)

1972-01-01

Astronaut John W. Young, commander of the Apollo 16 lunar landing mission, is photographed collecting lunar samples near North Ray crater during the third Apollo 16 extravehicular activity (EVA-3) at the Descartes landing site. This picture was taken by Astronaut Charles M. Duke Jr., lunar module pilot. Young is using the lunar surface rake and a set of tongs. The Lunar Roving Vehicle is parked in the field of large boulders in the background.

Fighting for Intelligence: A Brief Overview of the Academic Work of John L. Horn

PubMed Central

McArdle, John J.; Hofer, Scott M.

2015-01-01

John L. Horn (1928–2006) was a pioneer in multivariate thinking and the application of multivariate methods to research on intelligence and personality. His key works on individual differences in the methodological areas of factor analysis and the substantive areas of cognition are reviewed here. John was also our mentor, teacher, colleague, and friend. We overview John Horn’s main contributions to the field of intelligence by highlighting 3 issues about his methods of factor analysis and 3 of his substantive debates about intelligence. We first focus on Horn’s methodological demonstrations describing (a) the many uses of simulated random variables in exploratory factor analysis; (b) the exploratory uses of confirmatory factor analysis; and (c) the key differences between states, traits, and trait-changes. On a substantive basis, John believed that there were important individual differences among people in terms of cognition and personality. These sentiments led to his intellectual battles about (d) Spearman’s g theory of a unitary intelligence, (e) Guilford’s multifaceted model of intelligence, and (f) the Schaie and Baltes approach to defining the lack of decline of intelligence earlier in the life span. We conclude with a summary of John Horn’s unique approaches to dealing with common issues. PMID:26246642

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.

PubMed

Akalu, Yemsratch T; Rothlin, Carla V; Ghosh, Sourav

2017-03-01

Cancer immunotherapy utilizing T-cell checkpoint inhibitors has shown tremendous clinical success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive patients tend to have non-T-cell-inflamed tumors that lack markers associated with the activation of adaptive anti-tumor immune responses. Notably, elimination of cancer cells by T cells is critically dependent on the optimal activity of innate immune cells. Therefore, identifying new targets that regulate innate immune cell function and promote the engagement of adaptive tumoricidal responses is likely to lead to the development of improved therapies against cancer. Here, we review the TAM receptor tyrosine kinases-TYRO3, AXL, and MERTK-as an emerging class of innate immune checkpoints that participate in key steps of anti-tumoral immunity. Namely, TAM-mediated efferocytosis, negative regulation of dendritic cell activity, and dysregulated production of chemokines collectively favor the escape of malignant cells. Hence, disabling TAM signaling may promote engagement of adaptive immunity and complement T-cell checkpoint blockade. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Risk of cancer among patients with depressive disorder: a meta-analysis and implications.

PubMed

Ahn, Hee Kyung; Bae, Jeong Hun; Ahn, Hong Yup; Hwang, In Cheol

2016-12-01

The question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder. We searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression based on the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and/or the International Classification of Disease (ICD). We calculated a pooled odds ratio (OR) for developing cancer with the 95% confidence interval (CI). Nine studies fulfilled the eligibility criteria. In a random-effects model, patients with depressive disorder were at increased risk for cancer (OR, 1.26; 95% CI, 1.06-1.50, P = 0.01). However, a significant effect was observed only in low-quality studies (OR, 1.31; 95% CI, 1.05-1.63, P = 0.018), and not in high-quality studies (OR, 1.15; 95% CI, 0.85-1.56, P = 0.366). Our results did not demonstrate that people with depressive disorder are at increased risk for developing cancer. Well-designed prospective studies of recurrent or persistent depressive disorder that control for lifestyle factors including smoking are warranted. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

77 FR 23747 - Notice of Availability of the Proposed John Day Basin Resource Management Plan and Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... on public lands, and expanded scientific knowledge and information pertaining to the conservation of... John Day/Snake Resource Advisory Council and with representatives of local, State, and other Federal... received from the public, John Day/Snake Resource Advisory Council, John Day Basin RMP Cooperating Agencies...

John H Glenn Jr.

NASA Image and Video Library

2012-02-17

Mercury astronaut John Glenn speaks during the "On Shoulders of Giants" program celebrating 50 years of Americans in orbit, an era which began with Glenn's MA-6 mission on Feb. 20, 1962. The event was conducted in the Rocket Garden at the Kennedy Space Center Visitor Complex in Florida a few miles from the launch pad where Glenn and Scott Carpenter took flight in Mercury spacecraft. Glenn's launch aboard an Atlas rocket took with it the hopes of an entire nation and ushered in a new era of space travel that eventually led to Americans walking on the moon by the end of the 1960s. Glenn soon was followed into orbit by Scott Carpenter, Walter Schirra and Gordon Cooper. Their fellow Mercury astronauts Alan Shepard and Virgil "Gus" Grissom flew earlier suborbital flights. Deke Slayton, a member of NASA's original Mercury 7 astronauts, was grounded by a medical condition until the Apollo-Soyuz Test Project in 1975.

Astronaut John Glenn practices insertion into Mercury spacecraft

NASA Technical Reports Server (NTRS)

1962-01-01

Astronaut John H. Glenn Jr., pilot of the Mercury-Atlas 6 mission, practices insertion into the Mercury 'Friendship 7' spacecraft during MA-6 preflight training activity at Cape Canveral, Florida. He is wearing the full pressure suit and helmet (00993); Glenn practices insertion into Mercury capsule with help of a McDonnell Aircraft Corporation technician (00994).

Senator John Glenn training in Single Systems Trainer

NASA Image and Video Library

1998-03-30

S98-08642 (30 March 1998) --- U.S. Sen. John H. Glenn Jr. (D.-Ohio) is briefed on the usage of the single systems trainer at the Johnson Space Center (JSC). Glenn is in training for payload specialist duties for a scheduled late October flight aboard the Space Shuttle Discovery. Photo by Joe McNally, National Geographic, for NASA

John Ross--The Story of an American Indian.

ERIC Educational Resources Information Center

Harrell, Sara Gordon

First elected Principal Chief of the Cherokee Nation in 1828, John Ross served his people with courage and honor through a difficult and tragic period in their history. Born in 1790, he grew up when the Cherokees' world was rapidly changing and treaties with federal and state governments ended in broken promises and the loss of Cherokee lands. He…

Attentional bias and metacognitions in cancer survivors with high fear of cancer recurrence.

PubMed

Butow, P; Kelly, S; Thewes, B; Hruby, G; Sharpe, L; Beith, J

2015-04-01

Fear of cancer recurrence (FCR) is a common and severe problem amongst cancer survivors, but mechanisms to explain its development and maintenance are still lacking. The self-regulatory executive function (S-REF) model suggests that metacognitions and attentional bias to cancer-related words may explain high FCR. Thus, this study aimed to explore relationships between FCR, metacognitions and attentional bias in a mixed group of cancer survivors. Sixty-three early-stage breast or prostate cancer survivors, diagnosed within 6 months to 5 years prior to participation and who had completed all hospital-based treatment with no evidence of cancer recurrence were recruited through two metropolitan oncology clinics. Participants completed a questionnaire battery and the dot-probe task. Survivors with clinical FCR had significantly greater positive beliefs about worry (10.1 vs 7.4, p = 0.002) and beliefs about the uncontrollability and danger of worry (12.0 vs 7.7, p = 0.000) than those with non-clinical FCR, whereas the total metacognition score significantly predicted FCR in multiple regression analysis (β = 0.371, p = 0.001). No significant differences were detected between participants scoring above and below clinical FCR levels in attention bias indices. This study found partial support for the S-REF model of FCR, with metacognitions but not attentional bias found to be related to FCR. Further research is needed to explore attentional biases in more detail. Copyright © 2014 John Wiley & Sons, Ltd.

Cancer predisposition syndromes: lessons for truly precision medicine.

PubMed

Glaire, Mark A; Brown, Matthew; Church, David N; Tomlinson, Ian

2017-01-01

Cancer predisposition syndromes are typically uncommon, monogenic, high-penetrance disorders. Despite their rarity, they have proven to be highly clinically relevant in directing cancer prevention strategies. As such, they share notable similarities with an expanding class of low-frequency somatic mutations that are associated with a striking prognostic or predictive effect in the tumours in which they occur. In this review, we highlight these commonalities, with particular reference to mutations in the proofreading domain of replicative DNA polymerases. These molecular phenotypes may occur as either germline or somatic events, and in the latter case, have been shown to confer a favourable prognosis and potential increased benefit from immune checkpoint inhibition. We note that incorporation of these variants into clinical management algorithms will help refine patient management, and that this will be further improved by the inclusion of other germline variants, such as those that determine the likelihood of benefit or toxicity from anti-neoplastic therapy. Finally, we propose that such integrated patient and tumour profiling will be essential if we are to deliver truly precision medicine for cancer patients, but in a similar way to rare germline mutations, we must ensure that we identify and utilize rare somatic mutations with strong predictive and prognostic effects. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

9 CFR 80.4 - Segregation of animals positive to an official Johne's disease test during interstate movement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... official Johne's disease test during interstate movement. 80.4 Section 80.4 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.4 Segregation of animals positive to an official Johne's disease test during interstate movement. Animals that are positive...

9 CFR 80.4 - Segregation of animals positive to an official Johne's disease test during interstate movement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... official Johne's disease test during interstate movement. 80.4 Section 80.4 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.4 Segregation of animals positive to an official Johne's disease test during interstate movement. Animals that are positive...

9 CFR 80.4 - Segregation of animals positive to an official Johne's disease test during interstate movement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... official Johne's disease test during interstate movement. 80.4 Section 80.4 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.4 Segregation of animals positive to an official Johne's disease test during interstate movement. Animals that are positive...

9 CFR 80.4 - Segregation of animals positive to an official Johne's disease test during interstate movement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... official Johne's disease test during interstate movement. 80.4 Section 80.4 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.4 Segregation of animals positive to an official Johne's disease test during interstate movement. Animals that are positive...

9 CFR 80.4 - Segregation of animals positive to an official Johne's disease test during interstate movement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... official Johne's disease test during interstate movement. 80.4 Section 80.4 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.4 Segregation of animals positive to an official Johne's disease test during interstate movement. Animals that are positive...

76 FR 30394 - St. John Knits, Inc. Irvine, CA; Amended Certification Regarding Eligibility To Apply for Worker...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-25

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,839] St. John Knits, Inc..., 2011, applicable to workers of St. John Knits, Inc., Irvine, California. The workers are engaged in the... adjustment assistance was issued for all workers of St. John Knits, Sample Manufacturing Department, Irvine...

76 FR 16447 - St. John Knits, Inc., Irvine, CA; Amended Certification Regarding Eligibility To Apply for Worker...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,839] St. John Knits, Inc..., 2011, applicable to workers of St. John Knits, Inc., Irvine, California. The workers are engaged in the... adjustment assistance was issued for all workers of St. John Knits, Sample Manufacturing Department, Irvine...

Camera aboard 'Friendship 7' photographs John Glenn during spaceflight

NASA Technical Reports Server (NTRS)

1962-01-01

A camera aboard the 'Friendship 7' Mercury spacecraft photographs Astronaut John H. Glenn Jr. during the Mercury-Atlas 6 spaceflight (00302-3); Photographs Glenn as he uses a photometer to view the sun during sunsent on the MA-6 space flight (00304).

Astronaut John Casper checks equipment to support medical testing

NASA Image and Video Library

1994-03-05

STS062-10-010 (4-18 March 1994) --- Astronaut John H. Casper, mission commander, takes stock of paraphenalia used to support medical testing onboard Columbia's middeck. Casper was poind by four other veteran astronauts for 14 days of variegated research in earth orbit.

Special article: Horace Nelson MD, John Webster LDS--unrecognized Canadian anesthesia pioneers.

PubMed

Craig, Douglas; Chartrand, Daniel

2014-03-01

The timing of the earliest reported ether anesthetics in early 1847, in regions to become Canada in July 1867, was examined using information from on-line and library-based sources. Previous authors had identified the first reported ether anesthetic given by a visiting American dentist in January 1847 in Saint John, New Brunswick. Nevertheless, they had reported three different anesthetics as the second occurrence - which would denote the first anesthetic given by a resident of Canada. We confirmed that there were no reports of ether anesthetics being given in Canada before that reported on January 18, 1847 in Saint John. The information available for our review indicates that the second ether anesthetic, and the first by a Canadian, was given in Montreal by a dentist, Dr. John Horatio Webster, on February 20, 1847. The surgical assistant for that operation, Dr. Horace Nelson, later reported on animal and human experiments with ether, which he had led in Montreal starting in January 1847. Earlier authors, who may not have had access to the information now available, came to incorrect conclusions about the first ether anesthetic reported to have been given by a Canadian. Current information indicates that John Webster gave the first reported anesthetic in Montreal on February 20, 1847 following experiments with ether led by Horace Nelson. Both Webster and Nelson deserve recognition as Canadian anesthesia pioneers.

The cost of cancer: a retrospective analysis of the financial impact of cancer on young adults.

PubMed

Landwehr, Michelle S; Watson, Samantha E; Macpherson, Catherine F; Novak, Katherine A; Johnson, Rebecca H

2016-05-01

Young adult cancer survivors (YAs) are confronted with immense financial challenges in the wake of their treatment. Medical bills and loss of savings may cause YAs to forgo recommended medications or follow-up appointments. Young survivors with financial concerns also report depression, stress and anxiety. The Samfund is a national nonprofit organization that provides financial support to YAs post-treatment. To quantify the financial burden of cancer in YAs, a retrospective analysis was performed of data collected from Samfund grant applications of 334 YA cancer survivors. Grants were awarded between 2007 and 2013 and grant recipients were consented electronically in 2014 for retrospective data analysis. Recipients ranged from 19 to 39 years of age at the time of their grant applications. Descriptive statistics were calculated and compared to the Medical Expenditure Panel Survey (MEPS) and U.S. census data on age-matched peers. Financial indicators of YA cancer survivors are worse in many domains than those of age-matched controls. Furthermore, YA survivors in their 30s report more perilous prefunding financial situations than younger grant recipients. Cancer has a devastating and age-specific impact on the finances of YAs. Philanthropic grants from the cancer support community, in conjunction with healthcare policy reforms, have the potential to break the cycle of financial need and help YAs move forward with their lives after cancer treatment. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

The relative contributions of function, perceived psychological burden and partner support to cognitive distress in bladder cancer.

PubMed

Heyes, Susan M; Bond, Malcolm J; Harrington, Ann; Belan, Ingrid

2016-09-01

Bladder cancer is a genitourinary disease of increasing incidence. Despite improvements in treatment, outcomes remain equivocal with high recurrence rates. It is associated with poor psychosocial outcomes due to reduced functioning of the genitourinary system. The objective of these analyses was to query whether reported loss of function or the perception of psychological burden caused by this functional impedance was the key to understanding psychosocial outcomes. The sample comprised 119 participants with a confirmed diagnosis of bladder cancer. They completed a self-report questionnaire comprising the Bladder Cancer Index, Mini-mental Adjustment to Cancer Scale, Psychosocial Adjustment to Illness Scale and standard sociodemographic details. Simple mediation and serial mediation were used to explore the potential for psychological burden to mediate associations between loss of function and cognitive distress, and the potential additional contribution of positive partner support on these relationships. Age and duration of cancer were considered as covariates. Simple mediation demonstrated that the association between function and cognitive distress was fully mediated by perceived psychological burden. Serial mediation, which allowed for the addition of partner support, again demonstrated full mediation, with partner support being the key predictive variable. These analyses emphasise the importance of an appreciation of individuals' interpretation of the burden occasioned by bladder cancer and the role of a supportive partner. The implications for management discussions and support services in alleviating negative psychological outcomes in bladder cancer are highlighted. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Pesticides as risk factors for head and neck cancer: A review.

PubMed

Brasil, Veruska Lima Moura; Ramos Pinto, Mariana Bitu; Bonan, Roberta Ferreti; Kowalski, Luiz Paulo; da Cruz Perez, Danyel Elias

2018-02-28

Humans may be exposed to pesticides such as fungicides, herbicides, and insecticides, during occupational and non-occupational activities. Pesticides could be related to cancer development mainly because of their effects on the endocrine and immune systems and their cumulative effect. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of head and neck cancer (HNC). A literature search for cohort studies was conducted in the PubMed, Web of science, and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN) checklist. One thousand one hundred and thirty-two studies were identified. Thirty-two were included. Most of the studies found addressed occupational exposure to pesticides and were conducted in Europe and North America. Eleven high-quality studies were found. Most of them found no association between exposure to pesticides and increased risk of HNC. Two studies found some evidence of a positive association between pesticide (malathion and atrazine) exposure and thyroid cancer. The literature review does not support a clear evidence for association between pesticides exposure and HNC. Only limited evidence points to a positive association between exposure to some pesticides and thyroid cancer. Further standardized studies based on appropriate designs are required to clarify the effect of pesticides on the genesis of HNC, considering dose, length of exposure, and type of pesticide. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

STS-113 Mission Specialist John Herrington suits up for launch

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist John Herrington suits up for launch. Herrington will be making his first Shuttle flight. This is also the first launch of the first tribally enrolled Native American astronaut -- John B. Herrington -- on Space Transportation System. The primary mission for the crew is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for 8:15 p.m. EST.

Cancer stem cells: a metastasizing menace!

PubMed

Bandhavkar, Saurabh

2016-04-01

Cancer is one of the leading causes of death worldwide, and is estimated to be a reason of death of more than 18 billion people in the coming 5 years. Progress has been made in diagnosis and treatment of cancer; however, a sound understanding of the underlying cell biology still remains an unsolved mystery. Current treatments include a combination of radiation, surgery, and/or chemotherapy. However, these treatments are not a complete cure, aimed simply at shrinking the tumor and in majority of cases, there is a relapse of tumor. Several evidences suggest the presence of cancer stem cells (CSCs) or tumor-initiating stem-like cells, a small population of cells present in the tumor, capable of self-renewal and generation of differentiated progeny. The presence of these CSCs can be attributed to the failure of cancer treatments as these cells are believed to exhibit therapy resistance. As a result, increasing attention has been given to CSC research to resolve the therapeutic problems related to cancer. Progress in this field of research has led to the development of novel strategies to treat several malignancies and has become a hot topic of discussion. In this review, we will briefly focus on the main characteristics, therapeutic implications, and perspectives of CSCs in cancer therapy. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

76 FR 56215 - John H. Chafee Coastal Barrier Resources System; Baldwin and Mobile Counties, AL; Availability of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... aquatic habitat. These areas are depicted on a series of maps entitled ``John H. Chafee Coastal Barrier...] John H. Chafee Coastal Barrier Resources System; Baldwin and Mobile Counties, AL; Availability of Draft... availability of a John H. Chafee Coastal Barrier Resources System (CBRS) draft revised map, dated September 22...

Water quality and ground-water/surface-water interactions along the John River near Anaktuvuk Pass, Alaska, 2002-2003

USGS Publications Warehouse

Moran, Edward H.; Brabets, Timothy P.

2005-01-01

The headwaters of the John River are located near the village ofAnaktuvuk Pass in the central Brooks Range of interior Alaska. With the recent construction of a water-supply system and a wastewater-treatment plant, most homes in Anaktuvuk Pass now have modern water and wastewater systems. The effluent from the treatment plant discharges into a settling pond near a tributary of the John River. The headwaters of the John River are adjacent to Gates of the Arctic National Park and Preserve, and the John River is a designated Wild River. Due to the concern about possible water-quality effects from the wastewater effluent, the hydrology of the John River near Anaktuvuk Pass was studied from 2002 through 2003. Three streams form the John River atAnaktuvuk Pass: Contact Creek, Giant Creek, and the John RiverTributary. These streams drain areas of 90.3 km (super 2) , 120 km (super 2) , and 4.6 km (super 2) , respectively. Water-qualitydata collected from these streams from 2002-03 indicate that the waters are a calcium-bicarbonate type and that Giant Creek adds a sulfate component to the John River. The highest concentrations of bicarbonate, calcium, sodium, sulfate, and nitrate were found at the John River Tributary below the wastewater-treatment lagoon. These concentrations have little effect on the water quality of the John River because the flow of the John River Tributary is only about 2 percent of the John River flow. To better understand the ground-water/surface-water interactions of the upper John River, a numerical groundwater-flow model of the headwater area of the John River was constructed. Processes that occur during spring break-up, such as thawing of the active layer and the frost table and the resulting changes of storage capacity of the aquifer, were difficult to measure and simulate. Application and accuracy of the model is limited by the lack of specific hydrogeologic data both spatially and temporally. However

Obituary: John Norris Bahcall, 1934-2005

NASA Astrophysics Data System (ADS)

Striker, Jeremiah P.; Bahcall, Neta A.

2007-12-01

John Norris Bahcall, one of the most creative and influential astrophysicists of his generation — a scientist who helped prove what makes the Sun shine and helped make the Hubble Space Telescope a reality — passed away in Pasadena, California, on 17 August 2005. Bahcall died peacefully in his sleep from a rare blood disorder. For the past 35 years, Bahcall was the Richard Black Professor of Natural Sciences at the Institute for Advanced Study in Princeton, New Jersey, where he created one of the leading astrophysics programs in the world. Active and working to the end, Bahcall said that he was always grateful for a full and happy life that exceeded his wildest expectations. Bahcall died as he lived, surrounded by the family he loved, embracing life to its fullest, happy, working and joking to the end. Bahcall's stellar career encompassed seminal contributions in numerous fields of astrophysics as well as extraordinary leadership on behalf of the scientific community, including the American Astronomical Society, the American Physical Society, the National Academy of Sciences, NASA, and Congress. Bahcall's contributions made him one of the scientific leaders of his time. He had been recognized by numerous awards including the 1998 National Medal of Science from President Clinton, the Gold Medal of the Royal Astronomical Society, the Medal of the Swedish Royal Academy, the Dan David Award, the Fermi Award, the first Hans Bethe Prize, the Franklin Medal, the Comstock Prize in physics, NASA's Exceptional Scientific Achievement Medal, NASA's Distinguished Public Service Medal, and the top awards of the American Astronomical Society — including the Russell Award, the Heineman Prize, and the Warner Prize. Bahcall was elected to the National Academy of Sciences in 1976 and to the American Philosophical Society in 2001. He was the recipient of Honorary Degrees from numerous universities around the world. Bahcall's scientific interests and expertise ranged from neutrino

Historical Footage of John Glenn Friendship 7

NASA Technical Reports Server (NTRS)

1962-01-01

The Friendship mission launch on the 20th day of February marked the first time that an American attempts to orbit the Earth. Historical footage of John Glenn's suit up, ride out to the launch pad, countdown, liftoff, booster engine cutoff, and separation of the booster engine escape tower is shown. Views of the Earth, Glenn's manual control of the electrical fly-by wire system, and the recovery of the landing vehicle from the ocean are presented.

6. Historic American Buildings Survey John O. Brostrup, Photographer September ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey John O. Brostrup, Photographer September 4, 1936 10:50 A. M. VIEW OF SLAVE QUARTERS FROM SOUTHWEST (front.) - Rock Hall & Slave Quarters, Dickerson, Montgomery County, MD

4. Historic American Buildings Survey John O. Brostrup, Photographer March ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey John O. Brostrup, Photographer March 30, 1936 12:50 P. M. VIEW FROM SOUTHWEST - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

9. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey John O. Brostrup, Photographer April 20, 1936 10:00 A.M. VIEW FROM SOUTHEAST - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

11. Historic American Buildings Survey John O. Brostrup, Photographer Oct. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey John O. Brostrup, Photographer Oct. 12, 1936 9:25 A.M. VIEW FROM SOUTHEAST - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

10. Historic American Buildings Survey John O. Brostrup, Photographer March ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey John O. Brostrup, Photographer March 30, 1936 10:00 A.M. DETAIL FROM SOUTHEAST - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

16. Historic American Buildings Survey John O. Brostrup, Photographer March ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Historic American Buildings Survey John O. Brostrup, Photographer March 2, 1937 10:00 A. M. DETAIL OF CORNICE. - Thomas Law House, 1252 Sixth Street Southwest, Washington, District of Columbia, DC

3. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey John O. Brostrup, Photographer August 19, 1936 3:40 P. M. DETAIL OF DESCRIPTIVE PLAQUE. - Brookeville Academy, Georgia Avenue (State Route 97), Brookeville, Montgomery County, MD

Retrospective analysis of bevacizumab-induced hypertension and clinical outcome in patients with colorectal cancer and lung cancer.

PubMed

Nakaya, Aya; Kurata, Takayasu; Yokoi, Takashi; Iwamoto, Shigeyoshi; Torii, Yoshitaro; Katashiba, Yuichi; Ogata, Makoto; Hamada, Madoka; Kon, Masanori; Nomura, Shosaku

2016-07-01

Bevacizumab(Avastin(®) ), a humanized therapeutic monoclonal antibody that targets vascular endothelial growth factor, is widely used in cancer treatment. Patients who are treated with bevacizumab have an increased risk of developing systemic hypertension. However, the relationship between bevacizumab-induced hypertension and clinical outcome remains unclear. We aimed to evaluate the effect of bevacizumab-induced hypertension in terms of prognosis in patients with colorectal cancer and non-small cell lung cancer. The study included 632 patients, 317 patients with non-small cell lung cancer and 315 patients with colorectal cancer. All patients were treated with bevacizumab in combination with standard chemotherapy protocols, between April 2007 and December 2014. Blood pressure was measured before each treatment cycle. In the patient group with colorectal cancer, treated with bevacizumab, Grade 2-3 hypertension was present in 27.6%. In hypertensive patients with colorectal cancer, median overall survival was 42.6 months, compared with 20.6 months for normotensive patients in this group (P = 0.00071). In the patient group with non-small cell lung cancer, treated with bevacizumab, Grade 2-3 hypertension was present in 20.5%. In hypertensive patients with non-small cell lung cancer, median overall survival was 43.0 months, compared with 26.3 months for normotensive patients in this group (P = 0.00451). Patients who developed hypertension during treatment with bevacizumab for colorectal cancer and non-small cell lung cancer had significantly prolonged overall survival when compared with normotensive patients. Bevacizumab-induced hypertension may represent a biomarker for clinical benefit in cancer patients treated with bevacizumab. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Microtubule actin cross-linking factor 1, a novel potential target in cancer.

PubMed

Miao, Zhiping; Ali, Arshad; Hu, Lifang; Zhao, Fan; Yin, Chong; Chen, Chu; Yang, Tuanmin; Qian, Airong

2017-10-01

Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, deregulation of the cell cycle as well as resistance to apoptosis. The spectraplakin protein microtubule actin cross-linking factor 1 (MACF1) plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF1 initiates the tumor cell proliferation, and migration and metastasis in numerous cancers, such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF1 and its critical role in different human cancers. This will be helpful for researchers to investigate the novel functional role of MACF1 in human cancers and as a potential target to enhance the efficacy of therapeutic treatment modalities. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Closeup View - Astronaut John Glenn - Insertion - Mercury Capsule - Cape

NASA Image and Video Library

1962-02-20

S62-01004 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury Atlas 6 (MA-6) mission, participates in Mercury egress training during MA-6 preflight preparations. Glenn made the free world's first manned Earth-orbital flight on Feb. 20, 1962. Photo credit: NASA

John C. Belland: A Pioneer in 3D Graphics.

ERIC Educational Resources Information Center

Hay, Kenneth

2000-01-01

Provides a profile of the career of John Belland and his work in instructional technology. Highlights include his educational background, teaching experience in higher education, work in learning with 3D computer-generated animation, alternative paradigms of instructional design, and ideas of postmodernism. (LRW)

John Stuart Mill's Concepts of Quality and Pedagogical Norms.

ERIC Educational Resources Information Center

Kim, Ki Su

1986-01-01

Considers the paradoxical relationship between two pervasive educational goals--quality and equality. Sees this paradox embedded in John Stuart Mill's writings on education, which attempted to reconcile the utilitarian pleasure principle (which emphasizes quantitative measures), with a traditional differentiation among levels and kinds of desires…

Astronaut John Glenn leaving crew quarters prior to launch

NASA Image and Video Library

1962-02-20

S62-00222 (20 Feb. 1962) --- View of astronaut John H. Glenn Jr. and equipment specialist Joe Schmitt leaving crew quarters prior to Mercury-Atlas 6 (MA-6) mission. Glenn is in his pressure suit and is carrying the portable ventilation unit. Photo credit: NASA

Factors associated with psychological distress in women with breast cancer-related lymphoedema.

PubMed

Alcorso, Jessica; Sherman, Kerry A

2016-07-01

Previous research has shown that lymphoedema impacts negatively on an individual, including psychological distress and body image disturbance, particularly for younger women. This study identified psychological factors associated with distress in women with breast cancer-related lymphoedema and determined whether age moderated the specific relationship between body image disturbance and distress. Australian women (n = 166) diagnosed with breast cancer-related lymphoedema were recruited through a community-based breast cancer organisation and lymphoedema treatment clinics. Participants completed an online survey assessing lymphoedema-related cognitions (personal control, perceived treatment effectiveness, and consequences of lymphoedema), perceived ability to self-regulate lymphoedema-related negative affect, body image disturbance, psychological distress (depression, anxiety and stress), and demographic/medical information. Beliefs about the consequences, perceived effectiveness of treatment and controllability of lymphoedema, perceived ability to self-regulate negative affect, body image disturbance, and number of lymphoedema symptoms were correlated with depression, anxiety, and stress scores. Multivariate regression analyses indicated that body image disturbance was significantly associated with depression, anxiety, and stress, and perceived treatment effectiveness was associated with stress. Age was a significant moderator of the relationship between body image disturbance and depression and anxiety, with older women with greater body image disturbance more distressed. Health professionals need to be aware that women diagnosed with lymphoedema are at risk of experiencing psychological distress, particularly arising from body image disturbance and beliefs that treatment cannot control lymphoedema. Furthermore, older women may be at an increased risk of anxiety and depression arising from body image disturbance. Copyright © 2015 John Wiley & Sons, Ltd

9 CFR 80.3 - Movement of domestic animals that are positive to an official Johne's disease test.

Code of Federal Regulations, 2010 CFR

2010-01-01

... positive to an official Johne's disease test. 80.3 Section 80.3 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.3 Movement of domestic animals that are positive to an official Johne's disease test. (a) Movement of domestic animals for...

9 CFR 80.3 - Movement of domestic animals that are positive to an official Johne's disease test.

Code of Federal Regulations, 2011 CFR

2011-01-01

... positive to an official Johne's disease test. 80.3 Section 80.3 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.3 Movement of domestic animals that are positive to an official Johne's disease test. (a) Movement of domestic animals for...

9 CFR 80.3 - Movement of domestic animals that are positive to an official Johne's disease test.

Code of Federal Regulations, 2014 CFR

2014-01-01

... positive to an official Johne's disease test. 80.3 Section 80.3 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.3 Movement of domestic animals that are positive to an official Johne's disease test. (a) Movement of domestic animals for...

9 CFR 80.3 - Movement of domestic animals that are positive to an official Johne's disease test.

Code of Federal Regulations, 2012 CFR

2012-01-01

... positive to an official Johne's disease test. 80.3 Section 80.3 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.3 Movement of domestic animals that are positive to an official Johne's disease test. (a) Movement of domestic animals for...

9 CFR 80.3 - Movement of domestic animals that are positive to an official Johne's disease test.

Code of Federal Regulations, 2013 CFR

2013-01-01

... positive to an official Johne's disease test. 80.3 Section 80.3 Animals and Animal Products ANIMAL AND... (INCLUDING POULTRY) AND ANIMAL PRODUCTS JOHNE'S DISEASE IN DOMESTIC ANIMALS § 80.3 Movement of domestic animals that are positive to an official Johne's disease test. (a) Movement of domestic animals for...

“I’LL DIE WITH THE HAMMER IN MY HAND”: JOHN HENRYISM AS A PREDICTOR OF HAPPINESS

PubMed Central

Angner, Erik; Hullett, Sandral; Allison, Jeroan

2011-01-01

This paper examines the association between John Henryism – a behavioral predisposition to cope actively with psychosocial environmental stressors – and happiness. On the basis of previous research on aspiration and goal regulation, we predicted that John Henryism would be negatively associated with happiness when controlling for demographic factors and attainment in various domains of life. We tested the prediction in a sample of hypertensive participants (n=758) drawn from an inner-city, mainly African-American, safety-net hospital in Jefferson County, Alabama. Bivariate analysis revealed no association between John Henryism and attainment in six domains of life: marriage, children, education, employment, income, and health. However, a significant negative association between John Henryism and happiness was found both in bivariate analysis (Spearman’s ρ= −0.335; p<.001) and when controlling for demographic factors and attainment using ordinal logistic regression analysis. There was a significant interaction effect between John Henryism and gender: being male was positively associated with happiness among participants with low John Henryism, but negatively associated with happiness among participants with high John Henryism. While further study would be required in order to establish the extent to which these findings can be generalized as well as their causal underpinnings, the results indicate that John Henryism is negatively associated with happiness, especially among men, and underscore the limitations of using self-reported measures of happiness as proxies for well-being for purposes of public policy. PMID:21666864

Geochemical map of the North Fork John Day River Roadless Area, Grant County, Oregon

USGS Publications Warehouse

Evans, James G.

1986-01-01

The North Fork John Day River Roadless Area comprised 21,210 acres in the Umatilla and Wallowa-Whitman National Forests, Grant County, Oregon, about 30 miles northwest of Baker, Oregon. The irregularly shaped area extends for about 1 mile on both sides of a 25-mile segment of the North Fork John Day River from Big Creek on the west to North Fork John Day Campground on the east. Most of the roadless area is in the northern half of the Desolation Butte 15-minute quadrangle. The eastern end of the area is in parts of the Granite and Trout Meadows 7½-minute quadrangles.

Validation and application of a death proxy in adult cancer patients.

PubMed

Mealing, Nicole M; Dobbins, Timothy A; Pearson, Sallie-Anne

2012-07-01

PURPOSE: Fact of death is not always available on data sets used for pharmacoepidemiological research. Proxies may be an appropriate substitute in the absence of death data. The purposes of this study were to validate a proxy for death in adult cancer patients and to assess its performance when estimating survival in two cohorts of cancer patients. METHODS: We evaluated 30-, 60-, 90- and 180-day proxies overall and by cancer type using data from 12 394 Australian veterans with lung, colorectal, breast or prostate cancer. The proxy indicated death if the difference between the last dispensing record and the end of the observational period exceeded the proxy cutoff. We then compared actual survival to 90-day proxy estimates in a subset of 4090 veterans with 'full entitlements' for pharmaceutical items and in 3704 Australian women receiving trastuzumab for HER2+ metastatic breast cancer. RESULTS: The 90-day proxy was optimal with an overall sensitivity of 99.3% (95%CI: 98.4-99.7) and a specificity of 97.6% (95%CI: 91.8-99.4). These measures remained high when evaluated by cancer type and spread of disease. The application of the proxy using the most conservative date of death estimate (date of last dispensing) generally underestimated survival, with estimates up to 3 months shorter than survival based on fact of death. CONCLUSIONS: A 90-day death proxy is a robust substitute to identify death in a chronic population when fact of death is not available. The proxy is likely to be valid across a range of chronic diseases as it relies on the presence of 'regular' dispensing records for individual patients. Copyright © 2011 John Wiley & Sons, Ltd. Copyright © 2011 John Wiley & Sons, Ltd.

Epidemiology of head and neck cancer in Thailand.

PubMed

Tangjaturonrasme, Napadon; Vatanasapt, Patravoot; Bychkov, Andrey

2018-02-01

Cancer is the most common cause of death in Thailand, with the mortality almost doubled during 1998-2011 (from 48.4 to 95.2 per 100 000). The estimated number of new cancer cases in 2011 was 112 392. Our review provides baseline data on the current epidemiological situation with head and neck (HN) cancer in Thailand based on reports of the National Cancer Registry and findings from local and international publications. Collectively, HN cancer approaches age-standardized rate (ASR) incidence of 15.7 and 10.7 per 100 000 males and females, respectively, and is ranked among the top five dominant cancers in Thailand. The leading HN malignancies in men are oral (ASR incidence 4.6 per 100 000), nasopharyngeal (ASR 2.8) and laryngeal (ASR 2.7) cancers, while the most common cancers in women are thyroid (ASR 5.1) and oral (ASR 3.2) carcinomas. Some local habits (betel quid chewing, traditional cigarette smoking and alcohol intake) are associated with the high incidence of oral cancer in Northeast Thailand. Despite important prognostic significance, the role of human papillomavirus infection in various HN cancers from Thailand has been scarcely addressed. There is a growing incidence of thyroid cancer over the last two decades. The Thai population overall, compared to worldwide rates of HN malignancies, has a lower incidence of laryngeal and thyroid cancers but higher incidence of nasopharyngeal cancer. © 2017 John Wiley & Sons Australia, Ltd.

75 FR 8570 - Atlantic Ocean off John F. Kennedy Space Center, FL; Restricted Area

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... off John F. Kennedy Space Center, FL; Restricted Area AGENCY: United States Army Corps of Engineers... the Atlantic Ocean off the coast of the John F. Kennedy Space Center (KSC), Florida. The KSC is the main launch facility for the National Aeronautics and Space Administration (NASA) and they need to have...

The relevance of experiential avoidance in breast cancer distress: insights from a psychological group intervention.

PubMed

Aguirre-Camacho, Aldo; Pelletier, Guy; González-Márquez, Ana; Blanco-Donoso, Luis M; García-Borreguero, Paula; Moreno-Jiménez, Bernardo

2017-04-01

Research on the implication of experiential avoidance in the aetiology and maintenance of diverse forms of psychopathology has grown considerably over the last 10 years. However, the potential contribution of experiential avoidance to cancer-related distress has received limited attention. Accordingly, the objective of this study was to examine the association between experiential avoidance, symptoms of anxiety and depression, and quality of life (QoL) during the course of a psychological group intervention for women with breast cancer. Fifty-four women with breast cancer participated in a psychological group intervention designed to reduce distress and improve QoL. Participants completed measures of experiential avoidance, anxiety and depressive symptoms, and QoL upon the first and last sessions. A path analysis revealed that, after controlling for baseline measures, smaller reductions in experiential avoidance during the course of the intervention predicted smaller reductions in anxiety and depressive symptoms. Also, experiential avoidance had a negative indirect effect on QoL via depressive symptoms. Experiential avoidance may perpetuate the emotional problems commonly found in women with breast cancer and attenuate improvements associated with participation in psychological interventions. Implications for clinical practice in psycho-oncology are discussed. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

9. Photocopy of 1867 stereograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of 1867 stereograph. Original in library of John S. Lehmann Building, Missouri Botanical Garden. VIEW FROM NORTHWEST - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

7. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey John O. Brostrup, Photographer April 20, 1936 9:30 A.M. BRICK (east) GABLE VIEW - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

6. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey John O. Brostrup, Photographer April 29, 1936 11:10 A.M. VIEW FROM NORTHEAST (front) - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

14. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Historic American Buildings Survey John O. Brostrup, Photographer April 6, 1936 11:45 A. M. VIEW FROM WEST (front) - Thomas Law House, 1252 Sixth Street Southwest, Washington, District of Columbia, DC

4. Historic American Buildings Survey John R. Stinson, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey John R. Stinson, Photographer May 2, 1978 SOUTH (SIDE) ELEVATION SHOWING RELATIONSHIP TO URBAN ENVIRONMENT - Central School, 14403 East Pacific Avenue, Baldwin Park, Los Angeles County, CA

1. Historic American Buildings Survey John O. Brostrup, Photographer October ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey John O. Brostrup, Photographer October 20, 1936 12:50 P. M. VIEW FROM SOUTHWEST (front) - Samuel Gaither House, 3101 Mount Carmel Cemetery Road, Unity, Montgomery County, MD

John Glenn during preflight training for STS-95

NASA Image and Video Library

1998-04-14

S98-06947 (28 April 1998)--- Three crewmembers for the STS-95 mission take notes during a class room session in preparation for the scheduled October 1998 flight. From the left are U.S. Sen. John H. Glenn Jr.(D.-Ohio), Pedro Duque and Stephen K. Robinson. Duque represents the European Space Agency (ESA). Photo Credit: Joe McNally, National Geographic, for NASA.

Potential for interaction of kava and St. John's wort with drugs.

PubMed

Singh, Yadhu N

2005-08-22

The present interest and widespread use of herbal remedies has created the possibility of interaction between them and pharmaceutical drugs if they are used simultaneously. Before the recent reports of apparent hepatotoxicity associated with its use, kava (Piper methysticum Forst. F.), was one of the top 10 selling herbal remedies in Europe and North America. This adverse effect was not previously encountered with the traditional beverage which was prepared as a water infusion in contrast to the commercial products which are extracted with organic solvents. Kavalactones, the active principles in kava, are potent inhibitors of several of the CYP 450 enzymes, suggesting a high potential for causing pharmacokinetic interactions with drugs and other herbs which are metabolized by the same CYP 450 enzymes. Furthermore, some kavalactones have been shown to possess pharmacological effects, such as blockade of GABA receptors and sodium and calcium ion channels, which may lead to pharmacodynamic interactions with other substances which possess similar pharmacological proprieties. St. John's wort (Hypericum perforatum L.), used extensively for the treatment of mild to moderate clinical depression, has long been considered safer than the conventional pharmaceutical agents. However, its ability, through its active constituents hypericin, pseudohypericin and hyperforin, to induce intestinal P-glycoprotein/MRD1 and both intestinal and hepatic CYP3A4 enzyme, could markedly reduce the distribution and disposition of their co-substrates. In addition, St. John's wort is a potent uptake inhibitor of the neurotransmitters serotonin, norepinephrine and dopamine all of which have a role in mood control. Consequently, the very real potential for a pharmacodynamic interaction between the herb and pharmaceutical drugs which share this mechanism of action and, like St. John's wort, are used for mood elevation. However, presently there is very little evidence to substantiate actual

Chemoradiotherapy response in recurrent rectal cancer.

PubMed

Yu, Stanley K T; Bhangu, Aneel; Tait, Diana M; Tekkis, Paris; Wotherspoon, Andrew; Brown, Gina

2014-02-01

The efficacy of response to preoperative chemoradiotherapy (CRT) in recurrent versus primary rectal cancer has not been investigated. We compared radiological downsizing between primary and recurrent rectal cancers following CRT and determined the optimal size reduction threshold for response validated by survival outcomes. The proportional change in tumor length for primary and recurrent rectal cancers following CRT was compared using the independent sample t-test. Overall survival (OS) was calculated using the Kaplan-Meier product limit method and differences between survival for tumor size reduction thresholds of 30% (response evaluation criteria in solid tumors [RECIST]), 40%, and 50% after CRT in primary and recurrent rectal cancer groups. A total of 385 patients undergoing CRT were analyzed, 99 with recurrent rectal cancer and 286 with primary rectal cancer. The mean proportional reduction in maximum craniocaudal length was significantly higher for primary rectal tumors (33%) compared with recurrent rectal cancer (11%) (P < 0.01). There was no difference in OS for either primary or recurrent rectal cancer when ≤30% or ≤40% definitions were used. However, for both primary and recurrent tumors, significant differences in median 3-year OS were observed when a RECIST cut-off of 50% was used. OS was 99% versus 77% in primary and 100% versus 42% in recurrent rectal cancer (P = 0.002 and P = 0.03, respectively). Only patients that demonstrated >50% size reduction showed a survival benefit. Recurrent rectal cancer appears radioresistant compared with primary tumors for tumor size after CRT. Further investigation into improving/intensifying chemotherapy and radiotherapy for locally recurrent rectal cancer is justified. © 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Master John of Arderne (1307-1380): a founder of modern surgery.

PubMed

Pearn, John

2012-01-01

John of Arderne (1307-1380) was one founder of surgery as the profession is known today. He was the first English surgeon of whom biographic details survive. Born on the Arderne Estates at Newark, England, he served as a military surgeon in France in campaigns where gunpowder was used in combat for the first time. His best-known work, the Practica (De Arte Phisicali et de Cirurgia), formed the basis of practical surgical teaching in the medical schools of medieval Europe. Biographic research of primary and secondary archives and documents. John of Arderne's surgical practice was undertaken against a background of turbulent political, military and medical events. He survived the Black Death (1347) and its cyclical recurrences. He lived through the turbulent reigns of Edward II and Edward III and practised in London in the decades preceding the simmering unrest which preceded the Peasant's Revolt of 1381. Surgical and medical practice in the late Middle Ages was enmeshed in astrological beliefs. It was greatly influenced by church doctrine of disease causation. In this paper, the known details of John of Arderne's life are placed in the perspective of these societal and professional influences. He is one of several pre-Renaissance European doctors who were the first to challenge the received medical lore of Galen and later Arabic surgeons. Writing when he was 70 years of age, John of Arderne was the first to advocate that surgeons should trust their own clinical experience 'Wele ymagynyng subtile things' rather than following the directions of others, even including those advocated by himself. © 2011 The Author. ANZ Journal of Surgery © 2011 Royal Australasian College of Surgeons.

Harvey Cushing's Treatment of Skull Base Infections: The Johns Hopkins Experience

PubMed Central

Somasundaram, Aravind; Pendleton, Courtney; Raza, Shaan M.; Boahene, Kofi; Quinones-Hinojosa, Alfredo

2012-01-01

Objectives In this report, we review Dr. Cushing's early surgical cases at the Johns Hopkins Hospital, revealing details of his early operative approaches to infections of the skull base. Design Following institutional review board (IRB) approval, and through the courtesy of the Alan Mason Chesney Archives, we reviewed the Johns Hopkins Hospital surgical files from 1896 to 1912. Setting The Johns Hopkins Hospital, 1896 to 1912. Participants Eleven patients underwent operative treatment for suspected infections of the skull base. Main Outcome Measures The main outcome measure was operative approach, postoperative mortality, and condition recorded at the time of discharge. Results Eleven patients underwent operative intervention for infections of the skull base. The mean age was 30 years (range: 9 to 63). Of these patients, seven (64%) were female. The mean length of stay was 16.5 days (range: 4 to 34). Postoperatively eight patients were discharged in “well” or “good” condition, one patient remained “unimproved,” and two patients died during their admission. Conclusion Cushing's careful preoperative observation of patients, meticulous operative technique, and judicious use of postoperative drainage catheters contributed to a remarkably low mortality rate in his series of skull base infections. PMID:24083129

13. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Historic American Buildings Survey John O. Brostrup, Photographer April 20, 1936 9:50 A.M. ® NORTHEAST BEDROOM (east wall) - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

6. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 1:45 P.M. DETAIL OF SOUTHEAST ELEVATION. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

12. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey John O. Brostrup, Photographer April 20, 1936 9:45 A.M. ® NORTHEAST BEDROOM (north wall) - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

13. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 2:30 P.M. DETAIL OF PANELED DOOR. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

Astronaut John Young ingresses Apollo spacecraft command module in training

NASA Image and Video Library

1968-07-05

S68-40875 (5 July 1968) --- Astronaut John W. Young, Apollo 7 backup command module pilot, ingresses Apollo Spacecraft 101 Command Module during simulated altitude runs at the Kennedy Space Center's Pad 34.

2. Historic American Buildings Survey John O. Brostrup, Photographer October ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey John O. Brostrup, Photographer October 20, 1936 12:55 P. M. VIEW OF BARN FROM SOUTHWEST - Samuel Gaither Barn, 3101 Mount Carmel Cemetery Road, Unity, Montgomery County, MD

15. Photocopy of unexecuted competition drawing signed 'John Notman, Architect, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of unexecuted competition drawing signed 'John Notman, Architect, Philadelphia', circa 1854, from Historical Society of Pennsylvania), EAST ELEVATION - American Academy of Music, 232-246 South Broad Street, Philadelphia, Philadelphia County, PA

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL FIFTH FLOOR NORTH OFFICE AREA, FACING NORTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

Primary care and cancer: Facing the challenge of early diagnosis and survivorship.

PubMed

Round, Thomas

2017-05-01

With ageing populations and an increasing lifetime risk of cancer, primary care will continue to play an increasingly important role in early diagnosis and cancer survivorship, especially with the lowering of risk thresholds for referral and diagnostic investigations. However, primary care in many countries is in crisis with increasing workloads for primary care physicians. Potential solutions to these challenges will be outlined including development of multidisciplinary teams, diagnostic decision support, increasing access to diagnostics and cost-effective referral pathways. © 2017 John Wiley & Sons Ltd.

A qualitative study of the knowledge, behaviour and attitudes of patients with skin cancer regarding sunlight exposure and vitamin D.

PubMed

Rutkowski, David; Farrar, Mark D; Osman, Joanne E; Webb, Ann R; Rhodes, Lesley E

2017-07-01

Solar UVR is a major cause of skin cancer but also an important source of vitamin D (VitD), essential for musculoskeletal health. Conflicting public health messages may confuse patients with skin cancer prone to further skin cancer. To explore the knowledge, behaviour and attitudes of patients with skin cancer to sunlight exposure and VitD sources. Patients (n = 10) previously treated for multiple basal cell cancer in a hospital setting participated in focus group sessions with semi-structured discussions to explore: knowledge of VitD, sun-avoidance behaviour and attitude towards sunlight exposure messages. Thematic data analysis was performed using software programme MAXQDA11. Pre-existing knowledge of VitD was low. Most patients practised sun avoidance and were not inclined to increase exposure. Patients did not perceive VitD deficiency as a substantial risk to their own health, or a need to take VitD supplements. They aimed to increase VitD status through dietary intake, but knowledge of food VitD content was lacking. The patients with skin cancer, appropriate to their heightened skin cancer risk, appeared unlikely to increase their sun exposure to gain VitD. However, education is required regarding the generally low levels of VitD in foodstuffs, and the requirement for supplements/fortified foods if strict sun avoidance is employed. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

21 CFR 866.3336 - John Cunningham Virus serological reagents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false John Cunningham Virus serological reagents. 866.3336 Section 866.3336 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Serological Reagents § 866.3336...

The Virtues in John Wilson's Approach to Moral Education.

ERIC Educational Resources Information Center

Tobin, Bernadette

2000-01-01

Explores John Wilson's ideas on moral education, arguing against Wilson's criticism of virtue theory. Evaluates Wilson's account of moral education from the perspective of a neo-Aristotelian sense of morality and moral development. Focuses on a part of Wilson's work, "A New Introduction to Moral Education." (CMK)

John Archibald Wheeler: A study of mentoring in modern physics

NASA Astrophysics Data System (ADS)

Christensen, Terry M.

This dissertation has two objectives. The first objective is to determine where best to situate the study of mentoring (i.e. the 'making of scientists') on the landscape of the history of science and science studies. This task is accomplished by establishing mentoring studies as a link between the robust body of literature dealing with Research Schools and the emerging scholarship surrounding the development, dispersion, and evolution of pedagogy in the training of twentieth century physicists. The second, and perhaps more significant and novel objective, is to develop a means to quantitatively assess the mentoring workmanship of scientific craftsmen who preside over the final stages of preparation when apprentices are transformed into professional scientists. The project builds upon a 2006 Master's Thesis that examined John Archibald Wheeler's work as a mentor of theoretical physicists at Princeton University in the years 1938--1976. It includes Wheeler's work as a mentor at the University of Texas and is qualitatively and quantitatively enhanced by virtue of the author having access to five separate collections with archival holdings of John Wheeler's papers and correspondence, as well as having access to thirty one tape recorded interviews that feature John Wheeler as either the interviewee or a prominent subject of discussion. The project also benefited from the opportunity to meet with and gather background information from a number of John Wheeler's former colleagues and students. Included in the dissertation is a content analysis of the acknowledgements in 949 Ph.D. dissertations, 122 Master's Theses, and 670 Senior Theses that were submitted during Wheeler's career as an active mentor. By establishing a census of the students of the most active mentors at Princeton and Texas, it is possible to tabulate the publication record of these apprentice groups and obtain objective measures of mentoring efficacy. The dissertation concludes by discussing the wider

John H Glenn Jr. Wreath Laying Ceremony

NASA Image and Video Library

2016-12-09

A memorial wreath stands at the Heroes and Legends exhibit hall at the Kennedy Space Center Visitor Complex before a ceremony remembering astronaut Sen. John Glenn, who passed away Dec. 8, 2016 at age 95. Glenn, one of the first seven astronauts NASA chose to fly the first missions of the Space Age, gained worldwide acclaim during his Mercury mission that made him the first American to orbit the Earth. He flew again in 1998 aboard space shuttle Discovery at age 77.

Astronaut John Young displays drawing of Snoopy

NASA Technical Reports Server (NTRS)

1969-01-01

Astronaut John W. Young, Apollo 10 command module pilot, displays drawing of Snoopy in this color reproduction taken from the fourth telecast made by the color television camera aboard the Apollo 10 spacecraft. When this picture was made the Apollo 10 spacecraft was about half-way to the moon, or approximately 112,000 nautical miles from the earth. Snoopy will be the code name of the Lunar Module (LM) during Apollo 10 operations when the LM and CM are separated.

Mechanisms of navigating goals after testicular cancer: meaning and emotion regulation.

PubMed

Hoyt, Michael A; Nelson, Christian J; Darabos, Katie; Marín-Chollom, Amanda; Stanton, Annette L

2017-06-01

The navigation of major life goals can be challenging to cancer survivors, particularly during young adulthood. This study examined the relationships of goal navigation skills (e.g., goal identification, goal clarification, and goal adjustment) with having a sense of life meaning, emotion regulation coping processes, and physical and psychological health indicators in young adult survivors of testicular cancer. Men ages 18 to 29 years (N = 171; M age = 25.2, SD = 3.32) with a history of testicular cancer were recruited via the California State Cancer Registry and completed questionnaire measures including assessments of goal navigation, sense of meaning, emotional approach coping, and indicators of physical and psychological well-being. Goal navigation skills were negatively related to depressive symptoms (r = -0.41, p < 0.01) and positively related to physical functioning (r = 0.28, p < 0.01). Controlling for participant age and months since diagnosis, mediation models revealed significant indirect effects of sense of meaning on depressive symptoms (-0.50, p < 0.05) and physical functioning (0.34, p < 0.05). Similarly, emotion-regulating coping had significant indirect effects on depressive symptoms (-0.08, p < 0.05) and physical functioning (0.11, p < 0.05) CONCLUSIONS: Consistent with a self-regulation framework, goal navigation skill is related to physical and psychological well-being via its association with maintenance of a sense of meaning as well as successful attempts at regulation of emotions. The study provides preliminary evidence that these skill-based processes relate to adjustment to cancer in young adults. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Family involvement for breast cancer decision making among Chinese-American women.

PubMed

Lee, Shiuyu Katie C; Knobf, M Tish

2016-12-01

To describe family involvement in decision making for primary treatment in Chinese-American women with early-stage breast cancer. Qualitative data were collected in 2003 from semi-structured questions in interviews with a sample of Chinese-American (ChA) women with breast cancer, who were recruited from the metropolitan New York area. Responses to the questions were written in Chinese immediately during the interview and read back to the subject for accuracy and validation. Content analysis was used to inductively code and analyze the data to generate themes. The participants consisted of 123 ChA women with early stage breast cancer with a mean age of 48.7 years (±9.3) and who had lived in the United States a median of 13.6 years. Support and Caring was the major theme that described family involvement in the breast cancer decision-making process. Gathering Information, Being There, Navigating the Health Care System, Maintaining Family Life and Making the Decision described the aspects of family support in the process. The majority of women described the treatment decision making as a collaborative supportive process with the family, but limited English fluency, strong opinions, lack of a shared perspective, distant living proximity and competing work responsibilities of family members were stressful for the women and perceived as non-supportive. Family involvement in health care decision making is culturally embedded in Asian populations. Culturally sensitive patient and family consultation strategies are needed to assist informed treatment decision making in Chinese-American women diagnosed with breast cancer. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

17. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 4:30 P.M. DETAIL OF WINDOW, NORTHWEST WALL. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

8. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 1:15 P.M. DETAIL OF DOOR, NORTHEAST ELEVATION. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

4. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 12:30 P.M. DETAIL OF WINDOWS FROM SOUTH. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

9. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 3:45 P.M. DETAIL OF DOOR, NORTHEAST WALL. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

14. Historic American Buildings Survey John O. Brostrup, Photographer Oct. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Historic American Buildings Survey John O. Brostrup, Photographer Oct. 12, 1936 9:15 A.M. Detail of West Wall of Basement - Friendship, Kolbies Corner, State Routes 214 & 556, Largo, Prince George's County, MD

10. Historic American Buildings Survey John O. Brostrup, Photographer October ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey John O. Brostrup, Photographer October 19, 1936 1:40 P. M. DETAIL OF MUSIC CLOSET, MUSIC ROOM, NORTHEAST CORNER. - Grayhaven Manor, State Route 109 Vicinity, Poolesville, Montgomery County, MD

1. Historic American Buildings Survey John O. Brostrup, Photographer April ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey John O. Brostrup, Photographer April 21, 1936 11:15 A. M. VIEW FROM NORTHEAST (front) - Poplar Neck, U.S. Naval Research Station, Dangerfield Road, Cheltenham, Prince George's County, MD

Cancer prevention-the feasibility and acceptability of promoting breast cancer risk reduction in the screening setting through a lifestyle magazine.

PubMed

Macleod, Maureen; Anderson, Annie S

2018-03-01

Cancer prevention and early detection strategies are fundamental to reducing breast cancer burden. Offering prevention guidance on modifiable risk factors within early detection settings is rare. We aimed to evaluate the acceptability of a magazine focused on lifestyle and cancer prevention for use in breast screening clinics. A lifestyle magazine was developed and distributed within two breast screening settings in the West of Scotland over a 2-month period. Women were either offered the magazine on arrival or in a self-service format. Uptake was recorded by NHS staff. Women's views were sought via an evaluation questionnaire. Staff were interviewed on their experiences of intervention delivery. Uptake was greatest when offered to attendees (95% vs. 20% self-service). The evaluation questionnaire response rate was 17.3%. Almost 60% of respondents reported an increased knowledge about breast cancer and lifestyle and felt motivated to find out more about cancer prevention and 40% expressed intentions to make lifestyle changes. Over 90% of respondents thought lifestyle factors were important in breast cancer prevention. Staff feedback was positive, indicating no detrimental effects on workloads. In conclusion, a cancer prevention lifestyle magazine can be successfully delivered in the breast screening setting and deserves further exploration for roll out. © 2018 John Wiley & Sons Ltd.

75 FR 34643 - Atlantic Ocean Off John F. Kennedy Space Center, FL; Restricted Area

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... Off John F. Kennedy Space Center, FL; Restricted Area AGENCY: U.S. Army Corps of Engineers, DoD... establishing a new restricted area in the Atlantic Ocean off the coast of the John F. Kennedy Space Center (KSC), Florida. The KSC is the main launch facility for the National Aeronautics and Space Administration (NASA...

Sharing bad news of a lung cancer diagnosis: understanding through communication privacy management theory.

PubMed

Ngwenya, Nothando; Farquhar, Morag; Ewing, Gail

2016-08-01

The aim of this paper is to understand the process of information disclosure and privacy as patients share their news of lung cancer with significant others. Twenty patients with lung cancer and 17 family members/friends accompanying them at diagnosis-giving completed either individual or dyad semi-structured interviews. Initial thematic analysis, then Petronio's Communication Privacy Management theory was used to inform interpretation. Patients described a sense of ownership of the news of their cancer and sought control of how, when and with whom it was shared. Family members expressed a need to follow the patients' rules in sharing this news, which limited their own support systems. Patients and family members had to live within the relational communication boundaries in order to maintain their trusting relationship and avoid potential disruptions. Patients as individuals are strongly interlinked with significant others, which impacts on their experience of disclosing private information. This shapes their psychological processes and outcomes impacting on their illness experience. This should be considered when developing interventions to support patients with sharing bad news. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL TENTH FLOOR SOUTH WING CAFETERIA FOOD LINE, FACING NORTH - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

16. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 4:00 P.M. VIEW OF NORTHEAST WALL OF BEDROOM. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

14. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 2:45 P.M. DETAIL OF GRAINING ON PANELED DOOR. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

1. Historic American Buildings Survey, John O. Brostrup, Photographer November ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, John O. Brostrup, Photographer November 3, 1936 9:25 A.M. VIEW OF SUMMER KITCHEN AND WHITEHAUS FROM THE EAST, FRONT. - The Cloisters, Whitehaus & Summer Kitchen, Ephrata, Lancaster County, PA

John Wood Community College: The Contractual Common Market Concept.

ERIC Educational Resources Information Center

Heath, Paul R.

This paper describes the philosophy and operation of John Wood Community College (JWCC), located in Illinois, which uses neighboring private and proprietary colleges in Illinois, Missouri, and Iowa to provide instructional and support services for its students. Currently, six schools have contractual relationships with JWCC, with the result that…

John Stuart Mill on Freedom, Education, and Social Reform.

ERIC Educational Resources Information Center

Carbone, Peter F.

1983-01-01

Examines the social philosophy of John Stuart Mill, emphasizing his views on freedom, education, and social reform. Considers Mill's individualism and reformism, the conflict between freedom and control that characterizes his work, and the importance of freedom and education. Suggests caution in drawing educational implications from his work. (DAB)

Astronaut John Glenn - Egress Training Activity - Langley AFB, VA

NASA Image and Video Library

1960-12-12

B60-00285 (1960) --- Astronaut John H. Glenn Jr., pilot of the Mercury Atlas 6 spaceflight, emerges from an egress trainer during training activity at the Langley Research Center. He is attempting to transfer onto a life raft from the mock-up of the Mercury capsule. Photo credit: NASA

Astronaut John Glenn leaving crew quarters prior to launch

NASA Image and Video Library

1961-02-20

S62-00330 (1962) --- Astronaut John H. Glenn Jr. (left), Dr. William Douglas, astronauts flight surgeon, and equipment specialist Joe Schmitt leave crew quarters prior to Mercury-Atlas 6 (MA-6) mission. Glenn is in his pressure suit and is carrying the portable ventilation unit. Photo credit: NASA

Remembering John M. Olson (1929-2017).

PubMed

Blankenship, Robert E; Brune, Daniel C; Olson, Jon C

2018-02-19

Here we provide reflections of and a tribute to John M. Olson, a pioneering researcher in photosynthesis. We trace his career, which began at Wesleyan University and the University of Pennsylvania, and continued at Utrech in The Netherlands, Brookhaven National Laboratory, and Odense University in Denmark. He was the world expert on pigment organization in the green photosynthetic bacteria, and discovered and characterized the first chlorophyll-containing protein, which has come to be known as the Fenna-Matthews-Olson (FMO) protein. He also thought and wrote extensively on the origin and early evolution of photosynthesis. We include personal comments from Brian Matthews, Raymond Cox, Paolo Gerola, Beverly Pierson and Jon Olson.

John Glenn during preflight training for STS-95

NASA Image and Video Library

1998-04-14

S98-06936 (28 April 1998) --- U.S. Sen. John H. Glenn Jr. (D.-Ohio), is assisted by suit experts Jean Alexander and Carlous Gillis prior to a training session at the Johnson Space Center (JSC). The STS-95 crew members are getting prepared for a scheduled Oct. 29 launch aboard the Space Shuttle Discovery. The photo was taken by Joe McNally, National Geographic, for NASA.

Senator John Glenn training in Single Systems Trainer

NASA Image and Video Library

1998-03-30

S98-08640 (6 April 1998) --- U.S. Sen. John H. Glenn Jr. (D.-Ohio) temporarily occupies the commander's station in a space shuttle instruction facility called the single systems trainer. The senator is training as a payload specialist for the STS-95 mission, scheduled for launch aboard the Space Shuttle Discovery later this year. The photo was taken by Joe Mcnally, National Geographic, for NASA.

The validity of the distress thermometer in prostate cancer populations.

PubMed

Chambers, Suzanne K; Zajdlewicz, Leah; Youlden, Danny R; Holland, Jimmie C; Dunn, Jeff

2014-02-01

The Distress Thermometer (DT) is widely recommended for screening for distress after cancer. However, the validity of the DT in men with prostate cancer and over differing time points from diagnosis has not been well examined. Receiver operating characteristics analyses were used to evaluate the diagnostic accuracy of the DT compared with three commonly used standardised scales in two prospective and one cross-sectional survey of men with prostate cancer (n = 740, 189 and 463, respectively). Comparison scales included the Impact of Event Scale - Revised (IES-R, Study 1), the Hospital Anxiety and Depression Scale (HADS, Study 2) and the Brief Symptom Inventory-18 (BSI-18, Study 3). Study 1: the DT showed good accuracy against the IES-R at all time points (area under curves (AUCs) ranging from 0.84 to 0.88) and sensitivity was high (>85%). Study 2: the DT performed well against both the anxiety and depression subscales for HADS at baseline (AUC = 0.84 and 0.82, respectively), but sensitivity decreased substantially after 12 months. Study 3: validity was high for the anxiety (AUC = 0.90, sensitivity = 90%) and depression (AUC = 0.85, sensitivity = 74%) subscales of the BSI-18 but was poorer for somatization (AUC = 0.67, sensitivity = 52%). A DT cut-off between ≥3 and ≥6 maximised sensitivity and specificity across analyses. The DT is a valid tool to detect cancer-specific distress, anxiety and depression among prostate cancer patients, particularly close to diagnosis. A cut-off of ≥4 may be optimal soon after diagnosis, and for longer-term assessments, ≥3 was supported. © 2013 The Authors. Psycho-Oncology published by John Wiley & Sons, Ltd. © 2013 The Authors. Psycho-Oncology published by John Wiley & Sons, Ltd.

13. Photocopy of 1931 photograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of 1931 photograph. Original in library of John S. Lehmann Building, Missouri Botanical Garden. VIEW SHOWING ALTERED STAIRWAY AND ADDED COLUMNS - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

10. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 3:15 P.M. DETAIL OF DOOR, ENTRANCE HALL, SOUTHEAST WALL. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

11. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 3:25 P.M. DETAIL OF ARCH, ENTRANCE HALL, SOUTHEAST WALL. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

Astronaut John Young in Command Module Simulator during Apollo Simulation

NASA Technical Reports Server (NTRS)

1968-01-01

Astronaut John W. Young, command module pilot, inside the Command Module Simulator in bldg 5 during an Apollo Simulation. Astronauts Thomas P. Stafford, commander and Eugene A. Cernan, lunar module pilot are out of the view.

11. Photocopy of 1893 photograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of 1893 photograph. Original in library of John S. Lehmann Building, Missouri Botanical Garden. MUSEUM AND GARDEN GATE FROM THE NORTHEAST - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

1. VIEW NORTHNORTHEAST OF CARRIER JOHN F. KENNEDY (JFK) IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW NORTH-NORTHEAST OF CARRIER JOHN F. KENNEDY (JFK) IN DRYDOCK NO. 5 FOR SERVICE LIFE EXTENSION PROGRAM (SLEP). - Naval Base Philadelphia-Philadelphia Naval Shipyard, Dry Dock No. 5, League Island, Philadelphia, Philadelphia County, PA

Cultivating Hygiene as a Science: The Welch-Rose Report's Influence at Johns Hopkins and Beyond.

PubMed

Thomas, Karen Kruse

2016-03-01

In 1915, William Henry Welch and Wickliffe Rose submitted a report to the Rockefeller Foundation that became the template for public health professional education in the United States and abroad. Based on the Welch-Rose Report's recommendations, the Foundation awarded a grant to Johns Hopkins University in 1916 to establish the first independent graduate school of public health, with Welch serving as the founding dean. The Welch-Rose Report and, by extension, the Johns Hopkins School of Hygiene and Public Health established and transmitted a new model of scientific training that wove the laboratory mindset together with the methods of public health administration and epidemiologic fieldwork. During the School's first quarter-century, faculty and alumni were remarkably active in frontline public health problem-solving, as well as launching public health agencies and schools of all types and sizes. The most lasting contribution of the Welch-Rose Report and the Johns Hopkins School of Hygiene and Public Health, now the Johns Hopkins Bloomberg School of Public Health, has been to "cultivate the science of hygiene" to bring about exponential growth in the evidence base for public health. The schools that have adopted the Johns Hopkins model of public health education worldwide have produced professionals who have worked to achieve wide-ranging reforms dedicated to preserving life, protecting health, and preventing injury across populations and continents. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Epidemiology of breast cancer in Indian women.

PubMed

Malvia, Shreshtha; Bagadi, Sarangadhara Appalaraju; Dubey, Uma S; Saxena, Sunita

2017-08-01

Breast cancer has ranked number one cancer among Indian females with age adjusted rate as high as 25.8 per 100,000 women and mortality 12.7 per 100,000 women. Data reports from various latest national cancer registries were compared for incidence, mortality rates. The age adjusted incidence rate of carcinoma of the breast was found as high as 41 per 100,000 women for Delhi, followed by Chennai (37.9), Bangalore (34.4) and Thiruvananthapuram District (33.7). A statistically significant increase in age adjusted rate over time (1982-2014) in all the PBCRs namely Bangalore (annual percentage change: 2.84%), Barshi (1.87%), Bhopal (2.00%), Chennai (2.44%), Delhi (1.44%) and Mumbai (1.42%) was observed. Mortality-to-incidence ratio was found to be as high as 66 in rural registries whereas as low as 8 in urban registries. Besides this young age has been found as a major risk factor for breast cancer in Indian women. Breast cancer projection for India during time periods 2020 suggests the number to go as high as 1797900. Better health awareness and availability of breast cancer screening programmes and treatment facilities would cause a favorable and positive clinical picture in the country. © 2017 John Wiley & Sons Australia, Ltd.

Biopsychosocial problem-related distress in cancer: examining the role of sex and age.

PubMed

Clark, Karen; Bergerot, Cristiane Decat; Philip, Errol J; Buga, Sorin; Obenchain, Richard; Loscalzo, Matthew J

2017-10-01

The current study explores how sex and age relate to biopsychosocial distress by applying a large-scale analysis among individuals diagnosed with a variety of cancers. A retrospective study was conducted involving 6462 patients treated for cancer at a National Cancer Institute-designated comprehensive cancer center between 2009 and 2014. Patients were asked to complete the biopsychosocial problem-related distress touchscreen instrument prior to starting treatment as part of their routine clinical care. There was a significant interaction of age and sex on the total number of problems rated as high distress and the total number of problems that prompted a request to talk with a member of the team. Male patients between 18 and 39 reported significantly more problems as high distress than female patients in the same age group (mean = 5.34 and mean = 4.92, respectively; p = 0.005). A similar trend was found where male patients between 18-39 and 40-64 requested to talk with a member of the team significantly more often than female patients in these same age groups (mean = 3.25 and mean = 3.22 vs. mean = 2.70 and mean = 3.07, respectively; p = 0.016). The results of the current study serve to refute generalizations regarding age or gender demographics and support preferences and thus reinforce the need to offer services in the context of cancer in flexible and varied ways. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Two Key Theories in Education: Confucius and John Dewey

ERIC Educational Resources Information Center

Bonnie, Michael G.

2010-01-01

The following describes the philosophies of Confucius (Confucianism) and John Dewey (pragmatism/instrumentalism/experimentalism) and their views toward vocational, technical, general academic instruction, and the development of morals and values as espoused throughout Asia and America during a span of history from 551 BCE to 1949 CE. This is not…

John H Glenn Jr. Wreath Laying Ceremony

NASA Image and Video Library

2016-12-09

Former space shuttle astronaut Jon McBride speaks at the Heroes and Legends exhibit hall at the Kennedy Space Center Visitor Complex during a ceremony remembering astronaut Sen. John Glenn who passed away Dec. 8, 2016 at age 95. Glenn, one of the first seven astronauts NASA chose to fly the first missions of the Space Age, gained worldwide acclaim during his Mercury mission that made him the first American to orbit the Earth. He flew again in 1998 aboard space shuttle Discovery at age 77.

John H Glenn Jr. Wreath Laying Ceremony

NASA Image and Video Library

2016-12-09

News media members and visitors gather at the Heroes and Legends exhibit hall at the Kennedy Space Center Visitor Complex during a ceremony remembering astronaut Sen. John Glenn who passed away Dec. 8, 2016 at age 95. Glenn, one of the first seven astronauts NASA chose to fly the first missions of the Space Age, gained worldwide acclaim during his Mercury mission that made him the first American to orbit the Earth. He flew again in 1998 aboard space shuttle Discovery at age 77.

12. Historic American Buildings Survey John O. Brostrup, Photographer May ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey John O. Brostrup, Photographer May 6, 1937 2:15 P.M. VIEW OF STAIR, WEST CORNER OF ENTRANCE HALL. - Holly Hill, Southeast of Friendship off MD 631, Friendship, Anne Arundel County, MD

John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

John Ash, AIA, Photographer August 1997. DETAIL OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING RADIATOR AND WINDOWS, FACING EAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

MicroRNAs: A Puzzling Tool in Cancer Diagnostics and Therapy.

PubMed

D'Angelo, Barbara; Benedetti, Elisabetta; Cimini, Annamaria; Giordano, Antonio

2016-11-01

MicroRNAs (miRNAs) constitute a dominating class of small RNAs that regulate diverse cellular functions. Due the pivotal role of miRNAs in biological processes, a deregulated miRNA expression is likely involved in human cancers. MicroRNAs possess tumor suppressor capability, as well as display oncogenic characteristics. Interestingly, miRNAs exist in various biological fluids as circulating entities. Changes in the profile of circulating miRNAs are indicative of pathophysiological conditions in human cancer. This concept has led to consider circulating miRNAs valid biomarkers in cancer diagnostics. Furthermore, current research promotes the use of miRNAs as a target in cancer therapy. However, miRNAs are an evolving research field. Although miRNAs have been demonstrated to be potentially valuable tools both in cancer diagnosis and treatment, a greater effort should be made to improve our understanding of miRNAs biology. This review describes the biology of microRNAs, emphasizing on the use of miRNAs in cancer diagnostics and therapy. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Resilience in adults with cancer: development of a conceptual model.

PubMed

Deshields, Teresa L; Heiland, Mark F; Kracen, Amanda C; Dua, Priya

2016-01-01

Resilience is a construct addressed in the psycho-oncology literature and is especially relevant to cancer survivorship. The purpose of this paper is to propose a model for resilience that is specific to adults diagnosed with cancer. To establish the proposed model, a brief review of the various definitions of resilience and of the resilience literature in oncology is provided. The proposed model includes baseline attributes (personal and environmental) which impact how an individual responds to an adverse event, which in this paper is cancer-related. The survivor has an initial response that fits somewhere on the distress-resilience continuum; however, post-cancer experiences (and interventions) can modify the initial response through a process of recalibration. The literature reviewed indicates that resilience is a common response to cancer diagnosis or treatment. The proposed model supports the view of resilience as both an outcome and a dynamic process. Given the process of recalibration, a discussion is provided of interventions that might facilitate resilience in adults with cancer. Copyright © 2015 John Wiley & Sons, Ltd.

The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer.

PubMed

Winn, D M; Lee, Y-C A; Hashibe, M; Boffetta, P

2015-09-01

The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The psychosocial experiences of breast cancer amongst Black, South Asian and White survivors: do differences exist between ethnic groups?

PubMed

Patel-Kerai, Geeta; Harcourt, Diana; Rumsey, Nichola; Naqvi, Habib; White, Paul

2017-04-01

Very little UK-based research has examined breast cancer-related experiences of Black and Minority Ethnic populations, and we do not know whether the psychosocial impact of diagnosis and treatment in this group is any different to that of White women. Therefore, this study examined similarities and differences amongst Black, South Asian and White breast cancer survivors. A quantitative, cross-sectional survey was conducted; 173 breast cancer survivors (80 White, 53 South Asian and 40 Black) completed a questionnaire, which assessed psychological functioning, social support, body image and beliefs about cancer. Significant differences (p < 0.05) were reported between White and South Asian participants: compared with White women, South Asian participants reported higher levels of anxiety and depression, poorer quality of life and held higher levels of internal and fatalistic beliefs pertaining to cancer. Black and South Asian women reported higher levels of body image concerns than White women, and held stronger beliefs that God was in control of their cancer. South Asian women turned to religion as a source of support more than Black and White women. This study enhances current understanding of the experience and impact of breast cancer amongst Black and South Asian women, and demonstrates similarities and differences between the ethnic groups. The findings highlight implications for healthcare professionals, particularly in relation to providing culturally sensitive care and support to their patients. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.

PubMed

Kumar, Vikas; Mdzinarishvili, Alexander; Kiewert, Cornelia; Abbruscato, Thomas; Bickel, Ulrich; van der Schyf, Cornelis J; Klein, Jochen

2006-09-01

Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of affective disorders. Hyperforin, a constituent of St. John's wort, is known to modulate the release and re-uptake of various neurotransmitters, an action that likely underlies its antidepressive activity. We now report that hyperforin also has N-methyl-D-aspartate (NMDA)-antagonistic effects. Hyperforin (10 microM) was found to inhibit the NMDA-induced calcium influx into cortical neurons. In rat hippocampal slices, hyperforin inhibited the NMDA-receptor-mediated release of choline from phospholipids. Hyperforin also antagonized the increase of water content in freshly isolated hippocampal slices, and it counteracted, at 3 and 10 microM, the increase of water content induced by NMDA. Hyperforin was inactive, however, in two in vivo models of brain edema formation, middle cerebral artery occlusion and water intoxication in mice. In conclusion, hyperforin has NMDA-receptor-antagonistic and potential neuroprotective effects in vitro. This effect may contribute to the therapeutic effectiveness of St. John's wort extracts in some situations, for example, for relapse prevention in alcoholism.

12. Photocopy of 1889 photograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of 1889 photograph. Original in library of John S. Lehmann Building, Missouri Botanical Garden. HENRY SHAW LYING IN STATE, SHOWING STAIRWAY BEFORE ALTERATION - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

10. Photocopy of 1867 photograph. Original in library of John ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of 1867 photograph. Original in library of John S. Lehmann Building,Missouri Botanical Garden. VIEW FROM THE SOUTHWEST, SHOWING ORIGINAL SOUTH DOOR TREATMENT - Missouri Botanical Garden, Museum, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

1. Historic American Buildings Survey John O. Brostrup, Photographer September ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey John O. Brostrup, Photographer September 17, 1936 10:45 A. M. VIEW OF 1315 4th St., S. W., FROM NORTHEAST (front) - Wheat Row, 1315 Fourth Street Southwest, Washington, District of Columbia, DC

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

John Ash, AIA, Photographer August 1997. VIEW OF LOS ANGELES CITY HALL SEVENTH FLOOR SOUTH OFFICE AREA SHOWING WOOD AND GLASS PARTITIONS, FACING SOUTHEAST - Los Angeles City Hall, 200 North Spring Street, Los Angeles, Los Angeles County, CA

Lifetime prevalence of non-melanoma and melanoma skin cancer in Australian recreational and competitive surfers.

PubMed

Climstein, Mike; Furness, James; Hing, Wayne; Walsh, Joe

2016-07-01

Surfing is one of the most popular outdoor aquatic activities in Australia with an estimated 2.7 million recreational surfers; however, Australia has long been recognized as having the highest incidence of melanoma in the world, and it is the most common type of cancer in young Australians. The aim of this study was to investigate the lifetime prevalence of non-melanoma [basal cell carcinoma (BCC), squamous cell carcinoma (SCC)] and melanoma skin cancers in Australian recreational and competitive surfers. Australian surfers were invited to complete an online surveillance survey to determine the lifetime prevalence of non-melanoma and melanoma skin cancers. A total of 1348 surfers (56.9% recreational) participated in this study, of which 184 surfers reported a skin cancer (competitive n = 96, recreational n = 87). Of non-melanoma and melanoma cancers reported, BCC was the most common (6.8%), followed by melanoma (1.4%) and SCC (0.6%). The relative risk was higher (P < 0.001) in competitive vs. recreational surfers [OR 1.74 (CI 1.28-2.31)]. There was a higher (P < 0.05) number of skin cancers reported on the face (23.5%), back (16.4%) and arms (12.4%). There were significant trends (P < 0.001) in reported skin cancers between competitive and recreational surfers, as well as significantly (P < 0.001) more skin cancers reported in males (14.6%) than females (9.4%). Based upon these findings, individuals who surf are advised to regularly utilize sun protection strategies (avoid peak ultraviolet radiation (10 am-3 pm), rashvest, hat and sunscreen) and primary care physicians are recommended to regularly screen their patients who surf. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.