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Sample records for jonas vilys vytautas

  1. [Hans Jonas: Nature Conservation, Conservation of Life].

    PubMed

    Burgui Burgui, Mario

    2015-01-01

    This article discusses three of the problems that the German philosopher Hans Jonas studied. The first one addresses the need for a specific ethic dedicated to the moral dimension of environmental problems, from a different perspective to the traditional. The second problem is crucial in the discussion on environmental ethics: the value of the nature. Does the nature have an intrinsic value or an instrumental value only (to satisfy the interests of the human being)? The thesis of Jonas, which claimed that nature is a good in itself, were further elaborated here. And the third problem is the derivation of moral norms and the role of man in this ethic that recognizes a good in itself in nature. According to Jonas, the human being is not diminished by recognizing the intrinsic value of nature, since the man's uniqueness and value are unquestionable. From these three central issues, the paper highlights the importance of seeking the links between bioethics and environmental ethics to address the current environmental, social and economic crisis.

  2. Gauged Nambu-Jona-Lasinio inflation

    NASA Astrophysics Data System (ADS)

    Inagaki, T.; Odintsov, S. D.; Sakamoto, H.

    2015-12-01

    We investigate the gauged Nambu-Jona-Lasinio model in curved space-time at the large Nc limit and in slow-roll approximation. The model can be described by the renormalization group corrected gauge-Higgs-Yukawa theory with the corresponding compositeness conditions. Evaluating the renormalization group (RG) improved effective action, we show that such model can produce CMB fluctuations and find inflationary parameters: spectral index, tensor-to-scalar-ratio and running of the spectral index. We demonstrate that the model can naturally satisfy the Planck 2015 data and maybe considered as an alternative candidate for Higgs inflation.

  3. Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Andrews, Penny; Habashi, Nader M; Gatto, Louis A

    2016-12-01

    It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is a critical need to develop novel ventilation strategies that will protect the lung and reduce ARDS mortality. Protti et al. have begun to analyze the impact of mechanical ventilation on lung tissue using engineering methods in normal pigs ventilated for 54 h. They used these methods to assess the impact of a mechanical breath on dynamic and static global lung strain and energy load. Strain is the change in lung volume in response to an applied stress (i.e., Tidal Volume-Vt). This study has yielded a number of exciting new concepts including the following: (1) Individual mechanical breath parameters (e.g., Vt or Plateau Pressure) are not directly correlated with VILI but rather any combination of parameters that subject the lung to excessive dynamic strain and energy/power load will cause VILI; (2) all strain is not equal; dynamic strain resulting in a dynamic energy load (i.e., kinetic energy) is more damaging to lung tissue than static strain and energy load (i.e., potential energy); and (3) a critical consideration is not just the size of the Vt but the size of the lung that is being ventilated by this Vt. This key concept merits attention since our current protective ventilation strategies are fixated on the priority of keeping the Vt low. If the lung is fully inflated, a large Vt is not necessarily injurious. In conclusion, using engineering concepts to analyze the impact of the mechanical breath on the lung is a novel new approach to investigate VILI mechanisms and to help design the optimally protective breath. Data generated using these methods have challenged some of the current dogma surrounding the mechanisms of VILI and of the components in the mechanical breath necessary for lung protection.

  4. Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Andrews, Penny; Habashi, Nader M; Gatto, Louis A

    2016-12-01

    It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is a critical need to develop novel ventilation strategies that will protect the lung and reduce ARDS mortality. Protti et al. have begun to analyze the impact of mechanical ventilation on lung tissue using engineering methods in normal pigs ventilated for 54 h. They used these methods to assess the impact of a mechanical breath on dynamic and static global lung strain and energy load. Strain is the change in lung volume in response to an applied stress (i.e., Tidal Volume-Vt). This study has yielded a number of exciting new concepts including the following: (1) Individual mechanical breath parameters (e.g., Vt or Plateau Pressure) are not directly correlated with VILI but rather any combination of parameters that subject the lung to excessive dynamic strain and energy/power load will cause VILI; (2) all strain is not equal; dynamic strain resulting in a dynamic energy load (i.e., kinetic energy) is more damaging to lung tissue than static strain and energy load (i.e., potential energy); and (3) a critical consideration is not just the size of the Vt but the size of the lung that is being ventilated by this Vt. This key concept merits attention since our current protective ventilation strategies are fixated on the priority of keeping the Vt low. If the lung is fully inflated, a large Vt is not necessarily injurious. In conclusion, using engineering concepts to analyze the impact of the mechanical breath on the lung is a novel new approach to investigate VILI mechanisms and to help design the optimally protective breath. Data generated using these methods have challenged some of the current dogma surrounding the mechanisms of VILI and of the components in the mechanical breath necessary for lung protection. PMID:27316442

  5. Gluon fragmentation functions in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Yang, Dong-Jing; Li, Hsiang-nan

    2016-09-01

    We derive gluon fragmentation functions in the Nambu-Jona-Lasinio (NJL) model by treating a gluon as a pair of color lines formed by a fictitious quark and antiquark (q q ¯). Gluon elementary fragmentation functions are obtained from the quark and antiquark elementary fragmentation functions for emitting specific mesons in the NJL model under the requirement that the q q ¯ pair maintains in the flavor-singlet state after meson emissions. An integral equation, which iterates the gluon elementary fragmentation functions to all orders, is then solved to yield the gluon fragmentation functions at a model scale. It is observed that these solutions are stable with respect to variation of relevant model parameters, especially after QCD evolution to a higher scale is implemented. We show that the inclusion of the gluon fragmentation functions into the theoretical predictions from only the quark fragmentation functions greatly improves the agreement with the SLD data for the pion and kaon productions in e+e- annihilation. Our proposal provides a plausible construct for the gluon fragmentation functions, which are supposed to be null in the NJL model.

  6. Extensions and further applications of the nonlocal Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Hell, T.; Weise, W.; Kashiwa, K.

    2011-06-01

    The nonlocal Polyakov-loop-extended Nambu-Jona-Lasinio model is further improved by including momentum-dependent wave-function renormalization in the quark quasiparticle propagator. Both two- and three-flavor versions of this improved Polyakov-loop-extended Nambu-Jona-Lasinio model are discussed, the latter with inclusion of the (nonlocal) 't Hooft-Kobayashi-Maskawa determinant interaction in order to account for the axial U(1) anomaly. Thermodynamics and phases are investigated and compared with recent lattice-QCD results.

  7. Nonet meson properties in the Nambu-Jona-Lasinio model with dimensional versus cutoff regularization

    SciTech Connect

    Inagaki, T.; Kimura, D.; Kohyama, H.; Kvinikhidze, A.

    2011-02-01

    The Nambu-Jona-Lasinio model with a Kobayashi-Maskawa-'t Hooft term is one low energy effective theory of QCD which includes the U{sub A}(1) anomaly. We investigate nonet meson properties in this model with three flavors of quarks. We employ two types of regularizations, the dimensional and sharp cutoff ones. The model parameters are fixed phenomenologically for each regularization. Evaluating the kaon decay constant, the {eta} meson mass and the topological susceptibility, we show the regularization dependence of the results and discuss the applicability of the Nambu-Jona-Lasinio model.

  8. Emergence of a nonuniform pion condensate in the (1 + 1)-dimensional Nambu-Jona-Lasinio model

    SciTech Connect

    Gubina, N. V. Zhukovsky, V. Ch.; Klimenko, K. G.; Kurbanov, S. G.

    2013-11-15

    The (1 + 1)-dimensional Nambu-Jona-Lasinio model describing the system of two-flavor quarks is studied in the limit of a large number of colors in the presence of a baryon chemical potential Micro-Sign and an isospin chemical potential Micro-Sign {sub I}. The possible formation of a nonuniform pion condensate in dense quark matter is considered for the cases of both the massive and the massless model.

  9. Separating the why from the what: Reply to Jonas and Markon(2015).

    PubMed

    Harms, P D; Wood, Dustin; Spain, Seth M

    2016-01-01

    In this response to the commentary offered by Jonas and Markon (2015) on our earlier work, we address points of agreement and disagreement on the nature and utility of functionalist and descriptivist accounts of personality. Specifically, we argue that explanatory and conceptual parsimony is more appropriate than statistical parsimony for evaluating the proposed models, discuss ways in which functionalist and descriptivist approaches can complement one another, and provide some cautions about interpreting latent traits. PMID:26709412

  10. Pion-photon transition distribution amplitudes in the Nambu-Jona-Lasinio model

    SciTech Connect

    Courtoy, A.; Noguera, S.

    2007-11-01

    We define the pion-photon transition distribution amplitudes (TDA) in a field theoretic formalism from a covariant Bethe-Salpeter approach for the determination of the bound state. We apply our formalism to the Nambu-Jona-Lasinio model, as a realistic theory of the pion. The obtained vector and axial TDAs satisfy all features required by general considerations. In particular, sum rules and the polynomiality condition are explicitly verified. We have numerically proved that the odd coefficients in the polynomiality expansion of the vector TDA vanish in the chiral limit. The role of PCAC and the presence of a pion pole are explicitly shown.

  11. Phase diagram and critical properties in the Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Sousa, C. A. de; Costa, P.; Ruivo, M. C.; Hansen, H.

    2011-05-23

    We investigate the phase diagram of the so-called Polyakov-Nambu-Jona-Lasinio model at finite temperature and nonzero chemical potential with three quark flavours. Chiral and deconfinement phase transitions are discussed, and the relevant order-like parameters are analyzed. The results are compared with simple thermodynamic expectations and lattice data. A special attention is payed to the critical end point: as the strength of the flavour-mixing interaction becomes weaker, the critical end point moves to low temperatures and can even disappear.

  12. Pion transverse momentum dependent parton distributions in the Nambu and Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Noguera, Santiago; Scopetta, Sergio

    2015-11-01

    An explicit evaluation of the two pion transverse momentum dependent parton distributions at leading twist is presented, in the framework of the Nambu-Jona Lasinio model with Pauli-Villars regularization. The transverse momentum dependence of the obtained distributions is generated solely by the dynamics of the model. Using these results, the so called generalized Boer-Mulders shift is studied and compared with recent lattice data. The obtained agreement is very encouraging, in particular because no additional parameter has been introduced. A more conclusive comparison would require a precise knowledge of the QCD evolution of the transverse momentum dependent parton distributions under scrutiny.

  13. Dynamics and thermodynamics of a nonlocal Polyakov--Nambu--Jona-Lasinio model with running coupling

    SciTech Connect

    Hell, T.; Roessner, S.; Cristoforetti, M.; Weise, W.

    2009-01-01

    A nonlocal covariant extension of the two-flavor Nambu and Jona-Lasinio model is constructed, with built-in constraints from the running coupling of QCD at high-momentum and instanton physics at low-momentum scales. Chiral low-energy theorems and basic current algebra relations involving pion properties are shown to be reproduced. The momentum-dependent dynamical quark mass derived from this approach is in agreement with results from Dyson-Schwinger equations and lattice QCD. At finite temperature, inclusion of the Polyakov loop and its gauge invariant coupling to quarks reproduces the dynamical entanglement of the chiral and deconfinement crossover transitions as in the (local) Polyakov-loop-extended Nambu and Jona-Lasinio model, but now without the requirement of introducing an artificial momentum cutoff. Steps beyond the mean-field approximation are made including mesonic correlations through quark-antiquark ring summations. Various quantities of interest (pressure, energy density, speed of sound, etc.) are calculated and discussed in comparison with lattice QCD thermodynamics at zero chemical potential. The extension to finite quark chemical potential and the phase diagram in the (T,{mu})-plane are also discussed.

  14. The decay τ → K0K‑ντ in the extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Volkov, M. K.; Pivovarov, A. A.

    2016-07-01

    The full and differential widths of the decay τ → K0K‑ν τ are calculated in the framework of the extended Nambu-Jona-Lasinio model.The contributions of the subprocesses with the intermediate vector mesons ρ(770) and ρ(1450) are taken into account. The obtained results are in satisfactory agreement with the experimental data.

  15. The decay τ → K0K-ντ in the extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Volkov, M. K.; Pivovarov, A. A.

    2016-07-01

    The full and differential widths of the decay τ → K0K-ν τ are calculated in the framework of the extended Nambu-Jona-Lasinio model.The contributions of the subprocesses with the intermediate vector mesons ρ(770) and ρ(1450) are taken into account. The obtained results are in satisfactory agreement with the experimental data.

  16. Thermodynamics of two-color QCD and the Nambu Jona-Lasinio model

    SciTech Connect

    Ratti, Claudia; Weise, Wolfram

    2004-09-01

    We investigate two-flavor and two-color QCD at finite temperature and chemical potential in comparison with a corresponding Nambu and Jona-Lasinio model. By minimizing the thermodynamic potential of the system, we confirm that a second-order phase transition occurs at a value of the chemical potential equal to half the mass of the chiral Goldstone mode. For chemical potentials beyond this value the scalar diquarks undergo Bose condensation and the diquark condensate is nonzero. We evaluate the behavior of the chiral condensate, the diquark condensate, the baryon charge density and the masses of scalar diquark, antidiquark and pion, as functions of the chemical potential. Very good agreement is found with lattice QCD (N{sub c}=2) results. We also compare with a model based on leading-order chiral effective field theory.

  17. Beta function in the non-Abelian Nambu-Jona-Lasinio model in four dimensions

    SciTech Connect

    Alves, Van Sergio; Pinheiro, S. V. L.; Nascimento, Leonardo; Pena, Francisco

    2009-08-15

    In this paper we present the structure of the renormalization group in non-Abelian Nambu-Jona-Lasinio model up to 1-loop order. The model is not perturbatively renormalizable in the usual power counting sense, but it is treated as an effective theory, valid in a scale of energy in which p<<{lambda}, where p is the external momenta of the loop and {lambda} is a massive parameter that characterizes the couplings of the nonrenormalizable vertex. We clarify the tensorial structure of the interaction vertices and calculate the functions of the renormalization group. The analysis of the fixed points of the theory is also presented using Zimmermann's procedure for reducing the coupling constants. We find that the origin is an infrared-stable fixed point at low energies and also there is a nontrivial ultraviolet stable fixed point, indicating that the theory could be perturbatively investigated in the low momentum regime.

  18. Thermodynamics of a three-flavor nonlocal Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Hell, T.; Roessner, S.; Cristoforetti, M.; Weise, W.

    2010-04-01

    The present work generalizes a nonlocal version of the Polyakov-loop-extended Nambu and Jona-Lasinio (PNJL) model to the case of three active quark flavors, with inclusion of the axial U(1) anomaly. Gluon dynamics is incorporated through a gluonic background field, expressed in terms of the Polyakov loop. The thermodynamics of the nonlocal PNJL model accounts for both chiral and deconfinement transitions. Our results obtained in mean-field approximation are compared to lattice QCD results for N{sub f}=2+1 quark flavors. Additional pionic and kaonic contributions to the pressure are calculated in random phase approximation. Finally, this nonlocal three-flavor PNJL model is applied to the finite density region of the QCD phase diagram. It is confirmed that the existence and location of a critical point in this phase diagram depend sensitively on the strength of the axial U(1) breaking interaction.

  19. Solitonic modulation and Lifshitz point in an external magnetic field within Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Cao, Gaoqing; Huang, Anping

    2016-04-01

    We study the inhomogeneous solitonic modulation of a chiral condensate within the effective Nambu-Jona-Lasinio model when a constant external magnetic field is present. The self-consistent Pauli-Villars regularization scheme is adopted to manipulate the ultraviolet divergence encountered in the thermodynamic quantities. In order to efficiently determine the chiral restoration lines, a new kind of Ginzburg-Landau expansion approach is proposed here. At zero temperature, we find that both the upper and lower boundaries of the solitonic modulation oscillate with the magnetic field in the μ - B phase diagram which is actually the de Hass-van Alphan (dHvA) oscillation. It is very interesting to find out how the tricritical Lifshitz point (TL,μL) evolves with the magnetic field: There are also dHvA oscillations in the TL- B and μL- B curves, though the tricritical temperature TL increases monotonically with the magnetic field.

  20. Beyond voluntary consent: Hans Jonas on the moral requirements of human experimentation.

    PubMed Central

    Fethe, C

    1993-01-01

    In his essay, Philosophical Reflections on Experimenting with Human Subjects, Hans Jonas contends that except in cases of widespread medical emergencies, people do not have a moral or social obligation to volunteer to be subjects in medical experiments. He further argues that any appeal for volunteer subjects in medical experiments should whenever possible give priority to those who can identify with the project and offer a strong sense of commitment to its goals. The first of these claims is given support against some recent criticisms, but argument is offered to show that the second claim not only does little to enhance the stature of the standard requirement of free and informed consent but may even weaken the moral validity of the consent. PMID:8331645

  1. Shear viscosities from Kubo formalism in a large-Nc Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Lang, Robert; Kaiser, Norbert; Weise, Wolfram

    2015-10-01

    In this work the shear viscosity of strongly interacting matter is calculated within a two-flavor Nambu-Jona-Lasinio model as a function of temperature and chemical potential. The general Kubo formula is applied, incorporating the full Dirac structure of the thermal quark spectral function and avoiding commonly used on-shell approximations. Mesonic fluctuations contributing via Fock diagrams provide the dominant dissipative processes. The resulting ratio η/ s (shear viscosity over entropy density) decreases with temperature and chemical potential. Interpolating between our NJL results at low temperatures and hard thermal loop results at high temperatures a minimum slightly above the AdS/CFT benchmark η/ s = 1/4 τ is obtained.

  2. Experimentation with human subjects: a critique of the views of Hans Jonas.

    PubMed

    Schafer, A

    1983-06-01

    The ethics of experimentation on human subjects has become the subject of much debate among medical scientists and philosophers. Ethical problems and conflicts of interest become especially serious when research subjects are recruited from the class of patients. Are patients who are ill and suffering in a position to give voluntary and informed consent? Are there inevitable conflicts of interest and moral obligation when a personal physician recruits his own patients for an experiment designed partly to advance scientific knowledge and only partly as therapy for those patients? The views of the eminent American ethicist Hans Jonas on these issues are briefly summarised and criticised, and some moral guidelines are then proposed to regulate experimentation on human subjects.

  3. [Responsibility: Towards a fifth principle in blood transfusion's ethics. Applicability and limits of Hans Jonas's responsibility principle].

    PubMed

    Nélaton, C

    2016-09-01

    Nowadays, in France, anonymity, gratuity, volunteering, non-profit are recognized as ethical principles in blood transfusion. Can we add responsibility to this list? Can a logo named "Responsiblood" efficiently encourage blood donation? This article explores Hans Jonas's reform of the responsibility concept in order to measure its applicabilities and limits in the field of blood transfusion. Indeed, this concept - rethought by Jonas - seems to be a good encouragement which avoids the pitfalls of the concept of duty and of the idea of payment for blood donation. But can't we also see in this reform a threat to blood transfusion because of technophobia and the heuristics of fear that it involves? PMID:27424285

  4. Estimate of quantum corrections to the mass of the chiral soliton in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Weigel, H.; Alkofer, R.; Reinhardt, H.

    1995-01-01

    The Bethe-Salpeter equation for pion fluctuations off the chiral soliton in the Nambu-Jona-Lasinio model is constructed. By Goldstone's theorem this equation has rotational and translational zero-modes because the classical soliton is a localized stationary field configuration which violates rotational and translational invariance. Furthermore, the proper normalization of the fluctuating eigenmodes is obtained. Second quantization of the pion fluctuations off the chiral soliton provides an energy functional of the pion fluctuations which formally coincides with that of a harmonic oscillator. The corresponding quantum corrections to the soliton mass together with the semi-classical cranking prescription yield reasonable predictions for the masses of the nucleon and the Δ-resonance when the constituent quark mass is chosen to be about 400 MeV. These calculations are, to some extent, hampered by the non-confining character of the Nambu-Jona-Lasinio model. Comments on the 1/ NC counting scheme are added.

  5. Magnetic susceptibility of the QCD vacuum in a nonlocal SU(3) Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Pagura, V. P.; Gómez Dumm, D.; Noguera, S.; Scoccola, N. N.

    2016-09-01

    The magnetic susceptibility of the QCD vacuum is analyzed in the framework of a nonlocal SU(3) Polyakov-Nambu-Jona-Lasinio model. Considering two different model parametrizations, we estimate the values of the u - and s -quark tensor coefficients and magnetic susceptibilities and then we extend the analysis to finite temperature systems. Our numerical results are compared to those obtained in other theoretical approaches and in lattice QCD calculations.

  6. Thermal evolution of hybrid stars within the framework of a nonlocal Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    de Carvalho, S. M.; Negreiros, R.; Orsaria, M.; Contrera, G. A.; Weber, F.; Spinella, W.

    2015-09-01

    We study the thermal evolution of neutron stars containing deconfined quark matter in their core. Such objects are generally referred to as quark-hybrid stars. The confined hadronic matter in their core is described in the framework of nonlinear relativistic nuclear field theory. For the quark phase we use a nonlocal extension of the SU(3) Nambu-Jona-Lasinio model with vector interactions. The Gibbs condition is used to model phase equilibrium between confined hadronic matter and deconfined quark matter. Our study indicates that high-mass neutron stars may contain between 35 and 40% deconfined quark-hybrid matter in their cores. Neutron stars with canonical masses of around 1.4 M⊙ would not contain deconfined quark matter. The central proton fractions of the stars are found to be high, enabling them to cool rapidly. Very good agreement with the temperature evolution established for the neutron star in Cassiopeia A (Cas A) is obtained for one of our models (based on the popular NL3 nuclear parametrization), if the protons in the core of our stellar models are strongly paired, the repulsion among the quarks is mildly repulsive, and the mass of Cas A has a canonical value of 1.4 M⊙ .

  7. Nonlocal Ployakov-Nambu-Jona-Lasinio model and imaginary chemical potential

    SciTech Connect

    Kashiwa K.; Hell, T.; Weise, W.

    2011-09-21

    With the aim of setting constraints for the modeling of the QCD phase diagram, the phase structure of the two-flavor Polyakov-loop-extended Nambu and Jona-Lasinio (PNJL) model is investigated in the range of imaginary chemical potentials ({mu}{sub I}) and compared with available N{sub f} = 2 lattice QCD results. The calculations are performed using the advanced nonlocal version of the PNJL model with the inclusion of vector-type quasiparticle interactions between quarks, and with wave-function-renormalization corrections. It is demonstrated that the nonlocal PNJL model reproduces important features of QCD at finite {mu}{sub I}, such as the Roberge-Weiss (RW) periodicity and the RW transition. Chiral and deconfinement transition temperatures for N{sub f} = 2 turn out to coincide both at zero chemical potential and at finite {mu}{sub I}. Detailed studies are performed concerning the RW endpoint and its neighborhood where a first-order transition occurs.

  8. Chirally symmetric O(1/N{sub c}) corrections to the Nambu-Jona-Lasinio model

    SciTech Connect

    Dmitrasinovic, V.; Schulze, H.J.; Tegen, R.

    1995-03-01

    We develop an extended chirally symmetric self-consistent approximation scheme to the Nambu-Jona-Lasinio model, that corresponds to O(1/N{sub c}) corrections to the usual Hartree + random phase approximations. This scheme amounts to adding {open_quotes}meson cloud{close_quotes} contributions self-consistently to the quark self-energy and the meson polarization functions in a manner suggested by the weakly interacting nature of the quark and collective meson degrees of freedom of the NJL model in the large N{sub c} limit. We demonstrate explicitly that this scheme fulfills all the chiral symmetry theorems, namely the Goldstone theorem, the Goldberger-Treiman relation, and the conservation of the quark axial current. We explore the corrections to the quark self-energy and scalar condensate, as well as to the pion polarization function and the weak decay constant N{sub n}. The numerical evaluation of these corrections is presented and discussed. 23 refs., 14 figs., 2 tabs.

  9. Deconfinement transition in protoneutron stars: Analysis within the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Lugones, G.; Do Carmo, T. A. S.; Grunfeld, A. G.; Scoccola, N. N.

    2010-04-01

    We study the effect of color superconductivity and neutrino trapping on the deconfinement transition of hadronic matter into quark matter in a protoneutron star. To describe the strongly interacting matter a two-phase picture is adopted. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3)f Nambu-Jona-Lasinio effective model which includes color superconductivity. We impose color and flavor conservation during the transition in such a way that just deconfined quark matter is transitorily out of equilibrium with respect to weak interactions. We find that deconfinement is more difficult for small neutrino content and it is easier for lower temperatures although these effects are not too large. In addition they will tend to cancel each other as the protoneutron star cools and deleptonizes, resulting a transition density that is roughly constant along the evolution of the protoneutron star. According to these results the deconfinement transition is favored after substantial cooling and contraction of the protoneutron star.

  10. Deconfinement of neutron star matter within the Nambu-Jona-Lasinio model

    SciTech Connect

    Lugones, G.; Grunfeld, A. G.; Scoccola, N. N.; Villavicencio, C.

    2009-08-15

    We study the deconfinement transition of hadronic matter into quark matter under neutron star conditions assuming color and flavor conservation during the transition. We use a two-phase description. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3){sub f} Nambu-Jona-Lasinio effective model including color superconductivity. Deconfinement is considered to be a first order phase transition that conserves color and flavor. It gives a short-lived transitory colorless-quark phase that is not in {beta} equilibrium, and decays to a stable configuration in {tau}{approx}{tau}{sub weak}{approx}10{sup -8} s. However, in spite of being very short lived, the transition to this intermediate phase determines the onset of the transition inside neutron stars. We find the transition free-energy density for temperatures typical of neutron star interiors. We also find the critical mass above which compact stars should contain a quark core and below which they are safe with respect to a sudden transition to quark matter. Rather independently on the stiffness of the hadronic equation of state (EOS) we find that the critical mass of hadronic stars (without trapped neutrinos) is in the range of {approx}1.5-1.8 solar masses. This is in coincidence with previous results obtained within the MIT bag model.

  11. Thermodynamics and quark susceptibilities: A Monte Carlo approach to the Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Cristoforetti, M.; Hell, T.; Klein, B.; Weise, W.

    2010-06-01

    The Monte-Carlo method is applied to the Polyakov-loop extended Nambu-Jona-Lasinio model. This leads beyond the saddle-point approximation in a mean-field calculation and introduces fluctuations around the mean fields. We study the impact of fluctuations on the thermodynamics of the model, both in the case of pure gauge theory and including two quark flavors. In the two-flavor case, we calculate the second-order Taylor expansion coefficients of the thermodynamic grand canonical partition function with respect to the quark chemical potential and present a comparison with extrapolations from lattice QCD. We show that the introduction of fluctuations produces only small changes in the behavior of the order parameters for chiral symmetry restoration and the deconfinement transition. On the other hand, we find that fluctuations are necessary in order to reproduce lattice data for the flavor nondiagonal quark susceptibilities. Of particular importance are pion fields, the contribution of which is strictly zero in the saddle point approximation.

  12. Phase Diagram at Finite Chemical Potentials in the Nambu-Jona-Lasinio Model

    SciTech Connect

    Mu Chengfu; He Lianyi; Liu Yuxin

    2011-05-24

    We study the phase diagram of two flavor dense QCD at finite isospin and baryon chemical potentials in the framework of Nambu-Jona-Lasinio model. The system undergoes a crossover from a Bose-Einstein condensate of charged pions to a BCS superfluid with condensed quark-antiquark Cooper pairs when {mu}{sub I} increases at {mu}{sub B} = 0, and a nonzero baryon chemical potential serves as a mismatch between the pairing species. We observe a gapless pion condensation phase near the quadruple point ({mu}{sub I},{mu}{sub B}) = (m{sub {pi}},M{sub N}-1.5m{sub {pi}}) where m{sub {pi}}, M{sub N} are the vacuum masses of pions and nucleons, respectively. At very large isospin chemical potential, {mu}{sub I}>6.36m{sub {pi}}, an inhomogeneous LOFF superfluid phase appears in a window of {mu}{sub B}. Between the gapless and the LOFF phases, the pion superfluid phase and the normal quark matter phase are connected by a first order phase transition.

  13. Deconfinement transition in protoneutron stars: Analysis within the Nambu-Jona-Lasinio model

    SciTech Connect

    Lugones, G.; Carmo, T. A. S. do; Grunfeld, A. G.; Scoccola, N. N.

    2010-04-15

    We study the effect of color superconductivity and neutrino trapping on the deconfinement transition of hadronic matter into quark matter in a protoneutron star. To describe the strongly interacting matter a two-phase picture is adopted. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3){sub f} Nambu-Jona-Lasinio effective model which includes color superconductivity. We impose color and flavor conservation during the transition in such a way that just deconfined quark matter is transitorily out of equilibrium with respect to weak interactions. We find that deconfinement is more difficult for small neutrino content and it is easier for lower temperatures although these effects are not too large. In addition they will tend to cancel each other as the protoneutron star cools and deleptonizes, resulting a transition density that is roughly constant along the evolution of the protoneutron star. According to these results the deconfinement transition is favored after substantial cooling and contraction of the protoneutron star.

  14. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. . Inst. for Nuclear Theory Inst. fuer Theoretische Physik 2, Ruhr-Univ. Bochum ); Diakonov, D.; Petrov, V.; Pobylitsa, P.V. ); Park, N.W. Center for Theoretical Physics, Seoul National Univ. (Korea, Republic

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  15. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. |; Diakonov, D.; Petrov, V.; Pobylitsa, P.V.; Park, N.W. |

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle_times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  16. Thermomagnetic properties of the strong coupling in the local Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ayala, Alejandro; Dominguez, C. A.; Hernández, L. A.; Loewe, M.; Raya, Alfredo; Rojas, J. C.; Villavicencio, C.

    2016-09-01

    We study the thermomagnetic properties of the strong coupling constant G and quark mass M entering the Nambu-Jona-Lasinio model. For this purpose, we compute the quark condensate and compare it to lattice QCD (LQCD) results to extract the behavior of G and M as functions of the magnetic field strength and temperature. We find that at zero temperature, where the LQCD condensate is found to monotonically increase with the field strength, M also increases whereas G remains approximately constant. However, for temperatures above the chiral/deconfinement phase transitions, where the LQCD condensate is found to monotonically decrease with increasing field, M and G also decrease monotonically. For finite temperatures, below the transition temperature, we find that both G and M initially grow and then decrease with increasing field strength. To study possible consequences of the extracted temperature and magnetic field dependence of G and M , we compute the pressure and compare to LQCD results, finding an excellent qualitative agreement. In particular, we show that the transverse pressure, as a function of the field strength, is always negative for temperatures below the transition temperature whereas it starts off being positive and then becomes negative for temperatures above the transition temperature, also in agreement with LQCD results. We also show that for the longitudinal pressure to agree with LQCD calculations, the system should be described as a diamagnet. We argue that the turnover of M and G as functions of temperature and field strength is a key element that drives the behavior of the quark condensate going across the transition temperature and provides clues for a better understanding of the inverse magnetic catalysis phenomenon.

  17. The phase diagram in the SU(3) Nambu-Jona-Lasinio model with 't Hooft and eight-quark interactions

    SciTech Connect

    Moreira, J.; Hiller, B.; Blin, A. H.; Osipov, A. A.

    2010-08-05

    It is shown that the endpoint of the first order transition line which merges into a crossover regime in the phase diagram of the Nambu--Jona-Lasinio model, extended to include the six-quark 't Hooft and eight-quark interaction Lagrangians, is pushed towards vanishing chemical potential and higher temperatures with increasing strength of the OZI-violating eight-quark interactions. We clarify a connection between the location of the endpoint in the phase diagram and the mechanism of chiral symmetry breaking at the quark level. Constraints on the coupling strengths based on groundstate stability and physical considerations are explained.

  18. Shear and bulk viscosities of quark matter from quark-meson fluctuations in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ghosh, Sabyasachi; Peixoto, Thiago C.; Roy, Victor; Serna, Fernando E.; Krein, Gastão

    2016-04-01

    We have calculated the temperature dependence of shear η and bulk ζ viscosities of quark matter due to quark-meson fluctuations. The quark thermal width originating from quantum fluctuations of quark-π and quark-σ loops at finite temperature is calculated with the formalism of real-time thermal field theory. Temperature-dependent constituent-quark and meson masses and quark-meson couplings are obtained in the Nambu-Jona-Lasinio model. We found a nontrivial influence of the temperature-dependent masses and couplings on the Landau-cut structure of the quark self-energy. Our results for the ratios η /s and ζ /s , where s is the entropy density (also determined in the Nambu-Jona-Lasinio model in the quasiparticle approximation), are in fair agreement with results of the literature obtained from different models and techniques. In particular, our result for η /s has a minimum very close to the quantum lower bound, η /s =1 /4 π .

  19. Neutron stars: From the inner crust to the core with the (extended) Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Pais, Helena; Menezes, Débora P.; Providência, Constança

    2016-06-01

    Nucleonic matter is described within an SU(2) extended Nambu-Jona-Lasinio (NJL) model. Several parametrizations with different nuclear matter saturation properties are proposed. At subsaturation, nuclear pasta phases are calculated within two methods: the coexistence-phases approximation and the compressible liquid drop model, with the surface tension coefficient determined using a geometrical approach at zero temperature. A unified equation of state of stellar matter for the inner crust, with the nuclear pasta phases, and the core is calculated. The mass and radius of neutron stars within this framework are obtained for several families of hadronic and hybrid stars. The quark phase of hybrid stars is described within the SU(3) NJL model including a vector term. Stellar macroscopic properties are in accordance with some of the recent results in the literature.

  20. Mesonic correlation functions at finite temperature and density in the Nambu-Jona-Lasinio model with a Polyakov loop

    SciTech Connect

    Hansen, H.; Alberico, W. M.; Molinari, A.; Nardi, M.; Beraudo, A.

    2007-03-15

    We investigate the properties of scalar and pseudoscalar mesons at finite temperature and quark chemical potential in the framework of the Nambu-Jona-Lasinio (NJL) model coupled to the Polyakov loop (PNJL model) with the aim of taking into account features of both chiral symmetry breaking and deconfinement. The mesonic correlators are obtained by solving the Schwinger-Dyson equation in the RPA approximation with the Hartree (mean field) quark propagator at finite temperature and density. In the phase of broken chiral symmetry, a narrower width for the {sigma} meson is obtained with respect to the NJL case; on the other hand, the pion still behaves as a Goldstone boson. When chiral symmetry is restored, the pion and {sigma} spectral functions tend to merge. The Mott temperature for the pion is also computed.

  1. Spontaneous Electromagnetic Superconductivity of Vacuum in a Strong Magnetic Field: Evidence from the Nambu-Jona-Lasinio Model

    SciTech Connect

    Chernodub, M. N.

    2011-04-08

    Using an extended Nambu-Jona-Lasinio model as a low-energy effective model of QCD, we show that the vacuum in a strong external magnetic field (stronger than 10{sup 16} T) experiences a spontaneous phase transition to an electromagnetically superconducting state. The unexpected superconductivity of, basically, empty space is induced by emergence of quark-antiquark vector condensates with quantum numbers of electrically charged rho mesons. The superconducting phase possesses an anisotropic inhomogeneous structure similar to a periodic Abrikosov lattice in a type-II superconductor. The superconducting vacuum is made of a new type of vortices which are topological defects in the charged vector condensates. The superconductivity is realized along the axis of the magnetic field only. We argue that this effect is absent in pure QED.

  2. Pion polarizability in the Nambu-Jona-Lasinio model and possibilities of its experimental studies in Coulomb nuclear scattering

    SciTech Connect

    Bystritskiy, Yu. M.; Guskov, A. V.; Pervushin, V. N.; Volkov, M. K.

    2009-12-01

    The charge pion polarizability is calculated in the Nambu-Jona-Lasinio model, where the quark loops (in the mean field approximation) and the meson loops (in the 1/N{sub c} approximation) are taken into account. We show that quark loop contribution dominates because the meson loops strongly conceal each other. The sigma-pole contribution (m{sub {sigma}}{sup 2}-t){sup -1} plays the main role and contains strong t-dependence of the effective pion polarizability at the region |t|{>=}4M{sub {pi}}{sup 2}. Possibilities of experimental test of this sigma-pole effect in the reaction of Coulomb nuclear scattering are estimated for the COMPASS experiment.

  3. Decays τ → (η, η') K-ντ in the extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Volkov, M. K.; Pivovarov, A. A.

    2016-05-01

    The decays τ → (η, η') K-ντ are described in the framework of the extended Nambu-Jona-Lasinio model. Both full and differential widths of these decays are calculated. The vector and scalar channels are considered. In the vector channel, the subprocesses with the intermediate K*(892) and K*(1410) mesons play the main role. In the scalar channel, the subprocesses with the intermediate and K 0 * (800) and K 0 * (1430) mesons are taken into account. The scalar channel gives an insignificant contribution to the full width of the decay τ → η K-ντ. The obtained results are in satisfactory agreement with the experimental data. The prediction for the width of the process τ → η' K-ντ is made.

  4. A new species of sand crab Jonas Hombron & Jacquinot, 1846 (Crustacea:
    Decapoda: Brachyura: Corystidae) from the southeastern coast of India.

    PubMed

    Barathkumar, S; Das, N P I; Satpathy, K K

    2016-02-15

    A new species of sand crab of the genus Jonas Hombron & Jacquinot, 1846 (family Corystidae) is described from specimens collected from Kalpakkam, southeastern coast of India. Two other species, J. indicus (Chopra, 1935), and J. choprai Serène, 1971, have previously been recorded from this area. A detailed description of the new species is given and compared with the closely related J. formosae Balss, 1922, also from the Indo-West Pacific.

  5. 2+1 flavor Polyakov Nambu Jona-Lasinio model at finite temperature and nonzero chemical potential

    NASA Astrophysics Data System (ADS)

    Fu, Wei-Jie; Zhang, Zhao; Liu, Yu-Xin

    2008-01-01

    We extend the Polyakov-loop improved Nambu Jona-Lasinio model to 2+1 flavor case to study the chiral and deconfinement transitions of strongly interacting matter at finite temperature and nonzero chemical potential. The Polyakov loop, the chiral susceptibility of light quarks (u and d), and the strange quark number susceptibility as functions of temperature at zero chemical potential are determined and compared with the recent results of lattice QCD simulations. We find that there is always an inflection point in the curve of strange quark number susceptibility accompanying the appearance of the deconfinement phase, which is consistent with the result of lattice QCD simulations. Predictions for the case at nonzero chemical potential and finite temperature are made as well. We give the phase diagram in terms of the chemical potential and temperature and find that the critical end point moves down to low temperature and finally disappears with the decrease of the strength of the ’t Hooft flavor-mixing interaction.

  6. Hybrid stars using the quark-meson coupling and proper-time Nambu-Jona-Lasinio models

    NASA Astrophysics Data System (ADS)

    Whittenbury, D. L.; Matevosyan, H. H.; Thomas, A. W.

    2016-03-01

    Background: At high density deconfinement of hadronic matter may occur leading to quark matter. The immense densities reached in the inner core of massive neutron stars may be sufficient to facilitate the transition. Purpose: To investigate a crossover transition between two phenomenological models which epitomize quantum chromodynamics in two different regimes, while incorporating the influence of quark degrees of freedom in both. Method: We use the Hartree-Fock quark-meson coupling model and the proper-time regularized three-flavor Nambu-Jona-Lasinio model to describe hadronic and quark matter, respectively. Hybrid equations of state are obtained by interpolating the energy density as a function of total baryonic density and calculating the pressure. Results: Equations of state for hadronic, quark, and hybrid matter and the resulting mass versus radius curves for hybrid stars are shown, as well as other relevant physical quantities such as species fractions and the speed of sound in matter. Conclusions: The observations of massive neutron stars can certainly be explained within such a construction. However, the so-called thermodynamic correction arising from an interpolation method can have a considerable impact on the equation of state. The interpolation dependency of and physical meaning behind such corrections require further study.

  7. BCS, Nambu-Jona-Lasinio, and Han-Nambu: A sketch of Nambu's works in 1960-1965

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2016-06-01

    The years 1960-1965 were a remarkable period for Yoichiro Nambu. Starting with a reformulation of BCS theory with emphasis on gauge invariance, he recognized the realization of spontaneous chiral symmetry breaking in particle physics as evidenced by the Goldberger-Treiman relation. A concrete model of Nambu and Jona-Lasinio illustrated the essence of the Nambu-Goldstone theorem and the idea of soft pions. After the proposal of the quark model by Gell-Mann, he together with Han constructed an alternative model of integrally charged quarks with possible non-Abelian gluons. All these remarkable works were performed during the years 1960-1965. Here I briefly review those works following the original papers of Nambu chronologically, together with a brief introduction to a formulation of Noether's theorem and the Ward-Takahashi identities using path integrals. This article is mostly based on a lecture given at the Nambu Memorial Symposium held at Osaka City University in September 2015, where Nambu started his professional career.

  8. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    DOE PAGESBeta

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization schememore » for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.« less

  9. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    SciTech Connect

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization scheme for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.

  10. Evaluating the phase diagram at finite isospin and baryon chemical potentials in the Nambu-Jona-Lasinio model

    SciTech Connect

    Mu Chengfu; He Lianyi; Liu Yuxin

    2010-09-01

    We study the phase diagram of two-flavor dense QCD at finite isospin and baryon chemical potentials in the framework of the Nambu-Jona-Lasinio model. We focus on the case with arbitrary isospin chemical potential {mu}{sub I} and small baryon chemical potential {mu}{sub B{<=}{mu}B}{sup {chi}}where {mu}{sub B}{sup {chi}}is the critical chemical potential for the first-order chiral phase transition to happen at {mu}{sub I}=0. The {mu}{sub I}-{mu}{sub B} phase diagram shows a rich phase structure since the system undergoes a crossover from a Bose-Einstein condensate of charged pions to a BCS superfluid with condensed quark-antiquark Cooper pairs when {mu}{sub I} increases at {mu}{sub B}=0, and a nonzero baryon chemical potential serves as a mismatch between the pairing species. We observe a gapless pion condensation phase near the quadruple point ({mu}{sub I},{mu}{sub B})=(m{sub {pi}},M{sub N}-1.5m{sub {pi}}) where m{sub {pi}}, M{sub N} are the vacuum masses of pions and nucleons, respectively. The first-order chiral phase transition becomes a smooth crossover when {mu}{sub I}>0.82m{sub {pi}}. At very large isospin chemical potential, {mu}{sub I}>6.36m{sub {pi}}, an inhomogeneous Larkin-Ovchinnikov-Fulde-Ferrell superfluid phase, appears in a window of {mu}{sub B}, which should in principle exist for arbitrary large {mu}{sub I}. Between the gapless and the Larkin-Ovchinnikov-Fulde-Ferrell phases, the pion superfluid phase and the normal quark matter phase are connected by a first-order phase transition. In the normal phase above the superfluid domain, we find that charged pions are still bound states even though {mu}{sub I} becomes very large, which is quite different from that at finite temperature. Our phase diagram is in good agreement with that found in imbalanced cold atom systems.

  11. Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2014-12-01

    The Swedish astronomer Anders Jonas Ångström, born two centuries ago and professor of physics at Uppsala University, was one of the founders of optical spectroscopy. By using diffraction gratings out of glass plates with fine scorings across the face, he was able to observe the spectrum of the Sun, announcing in 1862 that he had discovered the lines of hydrogen in the solar spectrum. His most important work, 'Recherches sur la Spectre Solaire', including an atlas of close to a thousand spectral lines, became the standard of spectroscopy for at least a quarter of a century. This article deals with his life as well as his main contributions to the development of several areas of physical science, stressing his pioneer activities in spectroscopy.

  12. Nambu-Jona-Lasinio model description of weakly interacting Bose condensate and BEC-BCS crossover in dense QCD-like theories

    SciTech Connect

    He Lianyi

    2010-11-01

    QCD-like theories possess a positively definite fermion determinant at finite baryon chemical potential {mu}{sub B} and the lattice simulation can be successfully performed. While the chiral perturbation theories are sufficient to describe the Bose condensate at low density, to describe the crossover from Bose-Einstein condensation (BEC) to BCS superfluidity at moderate density we should use some fermionic effective model of QCD, such as the Nambu-Jona-Lasinio model. In this paper, using two-color two-flavor QCD as an example, we examine how the Nambu-Jona-Lasinio model describes the weakly interacting Bose condensate at low density and the BEC-BCS crossover at moderate density. Near the quantum phase transition point {mu}{sub B}=m{sub {pi}} (m{sub {pi}} is the mass of pion/diquark multiplet), the Ginzburg-Landau free energy at the mean-field level can be reduced to the Gross-Pitaevskii free energy describing a weakly repulsive Bose condensate with a diquark-diquark scattering length identical to that predicted by the chiral perturbation theories. The Goldstone mode recovers the Bogoliubov excitation in weakly interacting Bose condensates. The results of in-medium chiral and diquark condensates predicted by chiral perturbation theories are analytically recovered. The BEC-BCS crossover and meson Mott transition at moderate baryon chemical potential as well as the beyond-mean-field corrections are studied. Part of our results can also be applied to real QCD at finite baryon or isospin chemical potential.

  13. Role of two-flavor color superconductor pairing in a three-flavor Nambu-Jona-Lasinio model with axial anomaly

    SciTech Connect

    Basler, H.; Buballa, M.

    2010-11-01

    The phase diagram of strongly interacting matter is studied within a three-flavor Nambu-Jona-Lasinio model, which contains the coupling between chiral and diquark condensates through the axial anomaly. Our results show that it is essential to include the two-flavor color superconducting (2SC) phase in the analysis. While this is expected for realistic strange-quark masses, we find that even for equal up, down, and strange bare quark masses 2SC pairing can be favored due to spontaneous flavor symmetry breaking by the axial anomaly. This can lead to a rich phase structure, including BCS- and Bose-Einstein condensate-like 2SC and color-flavor locked phases and new endpoints. On the other hand, the low-temperature critical endpoint, which was found earlier in the same model without 2SC pairing, is almost removed from the phase diagram and cannot be reached from the low-density chirally broken phase without crossing a preceding first-order phase boundary. For physical quark masses no additional critical endpoint is found.

  14. The processes e+e-→ K±(K∗∓(892),K∗∓(1410)) and e+e-→ (η,η‧(958))(ϕ(1020),ϕ(1680)) in the extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Volkov, M. K.; Pivovarov, A. A.

    2016-09-01

    The processes e+e-→ K±K∗∓(892) and e+e-→ ηϕ(1020) are calculated in the framework of the extended Nambu-Jona-Lasinio model. The intermediate vector mesons ρ(770), ω(782), ϕ(1020) and their first radially excited states are taken into account. The obtained results are in satisfactory agreement with the experimental data. The predictions for the cross-sections of the reactions e+e-→ K±K∗∓(1410), e+e-→ η‧(958)ϕ(1020) and e+e-→ ηϕ(1680) were made.

  15. Aspects of U {sub A} (1) breaking in the Nambu and Jona-Lasinio model

    SciTech Connect

    Osipov, A.A. . E-mail: osipov@nusun.jinr.ru; Hiller, B. . E-mail: brigitte@teor.fis.uc.pt; Bernard, V. . E-mail: bernard@lpt6.u-strasbg.fr; Blin, A.H. . E-mail: alex@teor.fis.uc.pt

    2006-11-15

    The six-quark instanton induced 't Hooft interaction, which breaks the unwanted U {sub A} (1) symmetry of QCD, is a source of perturbative corrections to the leading order result formed by the four-quark forces with the U {sub L} (3) x U {sub R} (3) chiral symmetry. A detailed quantitative calculation is carried out to bosonize the model by the functional integral method. We concentrate our efforts on finding ways to integrate out the auxiliary bosonic variables. The functional integral over these variables cannot be evaluated exactly. We show that the modified stationary phase approach leads to a resummation within the perturbative series and calculate the integral in the 'two-loop' approximation. The result is a correction to the effective mesonic Lagrangian which may be important for the low-energy spectrum and dynamics of the scalar and pseudoscalar nonets.

  16. Hydrologic data of the coastal drainage basins of southeastern Massachusetts, Weir River, Hingham, to Jonas River, Kingston

    USGS Publications Warehouse

    Williams, John R.; Willey, Richard E.; Tasker, Gary D.

    1975-01-01

    This report presents, in tabular form, selected records of wells, test wells, borings, and springs; measurements of stream discharge, specific conductance, and temperature at partial-record stations; chemical analyses of ground water and surface water; and a summary of municipal water sources and additional sources available. The data were collected during a study of the drainage basins from 1969 to 1971 in cooperation with the Massachusetts Water Resources Commission. The report is released in order to make available to the public and to local, state, and federal agencies basic hydrologic information that may aid in planning water-resources development. Basic records contained in this report and streamflow data published elsewhere (U.S. Geol. Survey, 1960 et seq.) complement an interpretive report (Williams and Tasker, 1974).

  17. Nonlocal Polyakov-Nambu-Jona-Lasinio model with wave function renormalization at finite temperature and chemical potential

    SciTech Connect

    Contrera, G. A.; Orsaria, M.; Scoccola, N. N.

    2010-09-01

    We study the phase diagram of strongly interacting matter in the framework of a nonlocal SU(2) chiral quark model which includes wave function renormalization and coupling to the Polyakov loop. Both nonlocal interactions based on the frequently used exponential form factor, and on fits to the quark mass and renormalization functions obtained in lattice calculations are considered. Special attention is paid to the determination of the critical points, both in the chiral limit and at finite quark mass. In particular, we study the position of the critical end point as well as the value of the associated critical exponents for different model parametrizations.

  18. A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women.

    PubMed

    Huchko, Megan J; Sneden, Jennifer; Zakaras, Jennifer M; Smith-McCune, Karen; Sawaya, George; Maloba, May; Bukusi, Elizabeth Ann; Cohen, Craig R

    2015-01-01

    Visual inspection with Acetic Acid (VIA) and Visual Inspection with Lugol’s Iodine (VILI) are increasingly recommended in various cervical cancer screening protocols in low-resource settings. Although VIA is more widely used, VILI has been advocated as an easier and more specific screening test. VILI has not been well-validated as a stand-alone screening test, compared to VIA or validated for use in HIV-infected women. We carried out a randomized clinical trial to compare the diagnostic accuracy of VIA and VILI among HIV-infected women. Women attending the Family AIDS Care and Education Services (FACES) clinic in western Kenya were enrolled and randomized to undergo either VIA or VILI with colposcopy. Lesions suspicious for cervical intraepithelial neoplasia 2 or greater (CIN2+) were biopsied. Between October 2011 and June 2012, 654 were randomized to undergo VIA or VILI. The test positivity rates were 26.2% for VIA and 30.6% for VILI (p = 0.22). The rate of detection of CIN2+ was 7.7% in the VIA arm and 11.5% in the VILI arm (p = 0.10). There was no significant difference in the diagnostic performance of VIA and VILI for the detection of CIN2+. Sensitivity and specificity were 84.0% and 78.6%, respectively, for VIA and 84.2% and 76.4% for VILI. The positive and negative predictive values were 24.7% and 98.3% for VIA, and 31.7% and 97.4% for VILI. Among women with CD4+ count < 350, VILI had a significantly decreased specificity (66.2%) compared to VIA in the same group (83.9%, p = 0.02) and compared to VILI performed among women with CD4+ count ≥ 350 (79.7%, p = 0.02). VIA and VILI had similar diagnostic accuracy and rates of CIN2+ detection among HIV-infected women.

  19. Characterisation of 12 microsatellite loci in the Vietnamese commercial clam Lutraria rhynchaena Jonas 1844 (Heterodonta: Bivalvia: Mactridae) through next-generation sequencing.

    PubMed

    Thai, Binh Thanh; Tan, Mun Hua; Lee, Yin Peng; Gan, Han Ming; Tran, Trang Thi; Austin, Christopher M

    2016-05-01

    The marine clam Lutraria rhynchaena is gaining popularity as an aquaculture species in Asia. Lutraria populations are present in the wild throughout Vietnam and several stocks have been established and translocated for breeding and aquaculture grow-out purposes. In this study, we demonstrate the feasibility of utilising Illumina next-generation sequencing technology to streamline the identification and genotyping of microsatellite loci from this clam species. Based on an initial partial genome scan, 48 microsatellite markers with similar melting temperatures were identified and characterised. The 12 most suitable polymorphic loci were then genotyped using 51 individuals from a population in Quang Ninh Province, North Vietnam. Genetic variation was low (mean number of alleles per locus = 2.6; mean expected heterozygosity = 0.41). Two loci showed significant deviation from Hardy-Weinberg equilibrium (HWE) and the presence of null alleles, but there was no evidence of linkage disequilibrium among loci. Three additional populations were screened (n = 7-36) to test the geographic utility of the 12 loci, which revealed 100 % successful genotyping in two populations from central Vietnam (Nha Trang). However, a second population from north Vietnam (Co To) could not be successfully genotyped and morphological evidence and mitochondrial variation suggests that this population represents a cryptic species of Lutraria. Comparisons of the Qang Ninh and Nha Trang populations, excluding the 2 loci out of HWE, revealed statistically significant allelic variation at 4 loci. We reported the first microsatellite loci set for the marine clam Lutraria rhynchaena and demonstrated its potential in differentiating clam populations. Additionally, a cryptic species population of Lutraria rhynchaena was identified during initial loci development, underscoring the overlooked diversity of marine clam species in Vietnam and the need to genetically characterise population representatives prior to microsatellite development. The rapid identification and validation of microsatellite loci using next-generation sequencing technology warrant its integration into future microsatellite loci development for key aquaculture species in Vietnam and more generally, aquaculture countries in the South East Asia region. PMID:26922181

  20. Corrigendum to "Historical review: Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth" [Spectrochim. Acta Part B, 102 (2014) 12-23

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2015-07-01

    The following addendum should be added to the Acknowledgments of the above article. Due to the multiplicity of simultaneous activities in which I am continuously involved, I forgot mentioning that Prof. Dr. Klaus Hentschel, of the History Department of the University of Stuttgart (Germany) was helpful in obtaining some of the source material used in my review. In particular, Prof. Hentschel provided the scans of Anne Beckmann's work to which I was guided by passages in his book on "Mapping the spectrum", Oxford University Press (2002). I also followed his recommendation of contacting the Swedish historians of science, and Prof. Sven Widmalm among them; however, the correspondence was not successful.

  1. The Role of the Individual within Society: "The Giver" by Lois Lowry and "Brave New World" by Aldous Huxley. Thematic Unit.

    ERIC Educational Resources Information Center

    Tarner, Danielle; Umak, Adam

    Lois Lowry's award-winning novel, "The Giver," chronicles the strength of Jonas, an adolescent boy of 12 who lives in a utopian society. In the Community everyone is equal, and there is only a gray routine of existence. But Jonas is singled out by "The Giver," a wise old man who teaches Jonas the range of human emotions, and the two then plot the…

  2. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury.

    PubMed

    Kuethe, Dean O; Filipczak, Piotr T; Hix, Jeremy M; Gigliotti, Andrew P; Estépar, Raúl San José; Washko, George R; Baron, Rebecca M; Fredenburgh, Laura E

    2016-08-01

    Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration (P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI.

  3. Ecology and Pedagogy: On the Educational Implications of Postwar Environmental Philosophy

    ERIC Educational Resources Information Center

    Hotam, Yotam

    2010-01-01

    Environmentalism, an ethical imperative to preserve and protect nature, has become in the last decade a central ethical, political and pedagogic theme. Against this background, this article focuses on the postwar philosophy of the German-Jewish scholar Hans Jonas (1903-93). It points to Jonas's radical theory of pedagogic responsibility, and to…

  4. Non–Muscle Myosin Light Chain Kinase Isoform Is a Viable Molecular Target in Acute Inflammatory Lung Injury

    PubMed Central

    Mirzapoiazova, Tamara; Moitra, Jaideep; Moreno-Vinasco, Liliana; Sammani, Saad; Turner, Jerry R.; Chiang, Eddie T.; Evenoski, Carrie; Wang, Ting; Singleton, Patrick A.; Huang, Yong; Lussier, Yves A.; Watterson, D. Martin; Dudek, Steven M.; Garcia, Joe G. N.

    2011-01-01

    Acute lung injury (ALI) and mechanical ventilator-induced lung injury (VILI), major causes of acute respiratory failure with elevated morbidity and mortality, are characterized by significant pulmonary inflammation and alveolar/vascular barrier dysfunction. Previous studies highlighted the role of the non–muscle myosin light chain kinase isoform (nmMLCK) as an essential element of the inflammatory response, with variants in the MYLK gene that contribute to ALI susceptibility. To define nmMLCK involvement further in acute inflammatory syndromes, we used two murine models of inflammatory lung injury, induced by either an intratracheal administration of lipopolysaccharide (LPS model) or mechanical ventilation with increased tidal volumes (the VILI model). Intravenous delivery of the membrane-permeant MLC kinase peptide inhibitor, PIK, produced a dose-dependent attenuation of both LPS-induced lung inflammation and VILI (∼50% reductions in alveolar/vascular permeability and leukocyte influx). Intravenous injections of nmMLCK silencing RNA, either directly or as cargo within angiotensin-converting enzyme (ACE) antibody–conjugated liposomes (to target the pulmonary vasculature selectively), decreased nmMLCK lung expression (∼70% reduction) and significantly attenuated LPS-induced and VILI-induced lung inflammation (∼40% reduction in bronchoalveolar lavage protein). Compared with wild-type mice, nmMLCK knockout mice were significantly protected from VILI, with significant reductions in VILI-induced gene expression in biological pathways such as nrf2-mediated oxidative stress, coagulation, p53-signaling, leukocyte extravasation, and IL-6–signaling. These studies validate nmMLCK as an attractive target for ameliorating the adverse effects of dysregulated lung inflammation. PMID:20139351

  5. Concurrent evaluation of visual, cytological and HPV testing as screening methods for the early detection of cervical neoplasia in Mumbai, India.

    PubMed Central

    Shastri, Surendra S.; Dinshaw, Ketayun; Amin, Geetanjali; Goswami, Smriti; Patil, Sharmila; Chinoy, Roshini; Kane, S.; Kelkar, Rohini; Muwonge, Richard; Mahé, Cédric; Ajit, Dulhan; Sankaranarayanan, R.

    2005-01-01

    OBJECTIVE: Naked eye visual inspection with acetic acid (VIA), magnified VIA (VIAM), visual inspection with Lugol's iodine (VILI), cytology and human papillomavirus (HPV) testing were evaluated as screening methods for the detection of high-grade squamous intraepithelial lesions (HSIL) of the uterine cervix in a cross-sectional study in Mumbai, India. METHODS: Cytology, HPV testing, VIA, VIAM and VILI were carried out concurrently for 4039 women aged 30-65 years. All women were investigated with colposcopy and biopsies were taken from 939 women who had colposcopic abnormalities. The reference standard for final disease status was histology or negative colposcopy. The presence of HSIL was confirmed in 57 women (1.4%). The test characteristics for each method were calculated using standard formulae. RESULTS: The sensitivities of cytology, HPV testing, VIA, VIAM and VILI were 57.4%, 62.0%, 59.7%, 64.9%, and 75.4%, respectively (differences were not statistically significant). The specificities were 98.6%, 93.5%, 88.4%, 86.3%, and 84.3%, respectively. Adding a visual test to cytology or HPV testing in parallel combination resulted in a substantial increase in sensitivity, with a moderate decrease in specificity. The parallel combination of VILI and HPV testing resulted in a sensitivity of 92.0% and a specificity of 79.9%. CONCLUSION: As a single test, cytology had the best balance of sensitivity and specificity. Visual tests are promising in low-resource settings, such as India. The use of both VIA and VILI may be considered where good quality cytology or HPV testing are not feasible. The sensitivity of cytology and HPV testing increased significantly when combined with VIA or VILI. PMID:15798842

  6. Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study

    PubMed Central

    2011-01-01

    Background There is mounting experimental evidence that hypercapnic acidosis protects against lung injury. However, it is unclear if acidosis per se rather than hypercapnia is responsible for this beneficial effect. Therefore, we sought to evaluate the effects of hypercapnic (respiratory) versus normocapnic (metabolic) acidosis in an ex vivo model of ventilator-induced lung injury (VILI). Methods Sixty New Zealand white rabbit ventilated and perfused heart-lung preparations were used. Six study groups were evaluated. Respiratory acidosis (RA), metabolic acidosis (MA) and normocapnic-normoxic (Control - C) groups were randomized into high and low peak inspiratory pressures, respectively. Each preparation was ventilated for 1 hour according to a standardized ventilation protocol. Lung injury was evaluated by means of pulmonary edema formation (weight gain), changes in ultrafiltration coefficient, mean pulmonary artery pressure changes as well as histological alterations. Results HPC group gained significantly greater weight than HPMA, HPRA and all three LP groups (P = 0.024), while no difference was observed between HPMA and HPRA groups regarding weight gain. Neither group differ on ultrafiltration coefficient. HPMA group experienced greater increase in the mean pulmonary artery pressure at 20 min (P = 0.0276) and 40 min (P = 0.0012) compared with all other groups. Histology scores were significantly greater in HP vs. LP groups (p < 0.001). Conclusions In our experimental VILI model both metabolic acidosis and hypercapnic acidosis attenuated VILI-induced pulmonary edema implying a mechanism other than possible synergistic effects of acidosis with CO2 for VILI attenuation. PMID:21486492

  7. Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice

    PubMed Central

    Hashizume, Masahiro; Mouner, Marc; Chouteau, Joshua M.; Gorodnya, Olena M.; Ruchko, Mykhaylo V.; Potter, Barry J.; Wilson, Glenn L.; Gillespie, Mark N.

    2013-01-01

    This study tested the hypothesis that oxidative mitochondrial-targeted DNA (mtDNA) damage triggered ventilator-induced lung injury (VILI). Control mice and mice infused with a fusion protein targeting the DNA repair enzyme, 8-oxoguanine-DNA glycosylase 1 (OGG1) to mitochondria were mechanically ventilated with a range of peak inflation pressures (PIP) for specified durations. In minimal VILI (1 h at 40 cmH2O PIP), lung total extravascular albumin space increased 2.8-fold even though neither lung wet/dry (W/D) weight ratios nor bronchoalveolar lavage (BAL) macrophage inflammatory protein (MIP)-2 or IL-6 failed to differ from nonventilated or low PIP controls. This increase in albumin space was attenuated by OGG1. Moderately severe VILI (2 h at 40 cmH2O PIP) produced a 25-fold increase in total extravascular albumin space, a 60% increase in W/D weight ratio and marked increases in BAL MIP-2 and IL-6, accompanied by oxidative mitochondrial DNA damage, as well as decreases in the total tissue glutathione (GSH) and GSH/GSSH ratio compared with nonventilated lungs. All of these injury indices were attenuated in OGG1-treated mice. At the highest level of VILI (2 h at 50 cmH2O PIP), OGG1 failed to protect against massive lung edema and BAL cytokines or against depletion of the tissue GSH pool. Interestingly, whereas untreated mice died before completing the 2-h protocol, OGG1-treated mice lived for the duration of observation. Thus mitochondrially targeted OGG1 prevented VILI over a range of ventilation times and pressures and enhanced survival in the most severely injured group. These findings support the concept that oxidative mtDNA damage caused by high PIP triggers induction of acute lung inflammation and injury. PMID:23241530

  8. Dexamethasone Attenuates VEGF Expression and Inflammation but Not Barrier Dysfunction in a Murine Model of Ventilator–Induced Lung Injury

    PubMed Central

    Hegeman, Maria A.; Hennus, Marije P.; Cobelens, Pieter M.; Kavelaars, Annemieke; Jansen, Nicolaas J. G.; Schultz, Marcus J.; van Vught, Adrianus J.; Heijnen, Cobi J.

    2013-01-01

    Background Ventilator–induced lung injury (VILI) is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular endothelial growth factor (VEGF) has been proposed to be involved in the pathogenesis of VILI. This study examines the inhibitory effect of dexamethasone on VEGF expression, inflammation and alveolar–capillary barrier dysfunction in an established murine model of VILI. Methods Healthy male C57Bl/6 mice were anesthetized, tracheotomized and mechanically ventilated for 5 hours with an inspiratory pressure of 10 cmH2O (“lower” tidal volumes of ∼7.5 ml/kg; LVT) or 18 cmH2O (“higher” tidal volumes of ∼15 ml/kg; HVT). Dexamethasone was intravenously administered at the initiation of HVT–ventilation. Non–ventilated mice served as controls. Study endpoints included VEGF and inflammatory mediator expression in lung tissue, neutrophil and protein levels in bronchoalveolar lavage fluid, PaO2 to FiO2 ratios and lung wet to dry ratios. Results Particularly HVT–ventilation led to alveolar–capillary barrier dysfunction as reflected by reduced PaO2 to FiO2 ratios, elevated alveolar protein levels and increased lung wet to dry ratios. Moreover, VILI was associated with enhanced VEGF production, inflammatory mediator expression and neutrophil infiltration. Dexamethasone treatment inhibited VEGF and pro–inflammatory response in lungs of HVT–ventilated mice, without improving alveolar–capillary permeability, gas exchange and pulmonary edema formation. Conclusions Dexamethasone treatment completely abolishes ventilator–induced VEGF expression and inflammation. However, dexamethasone does not protect against alveolar–capillary barrier dysfunction in an established murine model of VILI. PMID:23451215

  9. Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

    PubMed

    Hashizume, Masahiro; Mouner, Marc; Chouteau, Joshua M; Gorodnya, Olena M; Ruchko, Mykhaylo V; Potter, Barry J; Wilson, Glenn L; Gillespie, Mark N; Parker, James C

    2013-02-15

    This study tested the hypothesis that oxidative mitochondrial-targeted DNA (mtDNA) damage triggered ventilator-induced lung injury (VILI). Control mice and mice infused with a fusion protein targeting the DNA repair enzyme, 8-oxoguanine-DNA glycosylase 1 (OGG1) to mitochondria were mechanically ventilated with a range of peak inflation pressures (PIP) for specified durations. In minimal VILI (1 h at 40 cmH(2)O PIP), lung total extravascular albumin space increased 2.8-fold even though neither lung wet/dry (W/D) weight ratios nor bronchoalveolar lavage (BAL) macrophage inflammatory protein (MIP)-2 or IL-6 failed to differ from nonventilated or low PIP controls. This increase in albumin space was attenuated by OGG1. Moderately severe VILI (2 h at 40 cmH(2)O PIP) produced a 25-fold increase in total extravascular albumin space, a 60% increase in W/D weight ratio and marked increases in BAL MIP-2 and IL-6, accompanied by oxidative mitochondrial DNA damage, as well as decreases in the total tissue glutathione (GSH) and GSH/GSSH ratio compared with nonventilated lungs. All of these injury indices were attenuated in OGG1-treated mice. At the highest level of VILI (2 h at 50 cmH(2)O PIP), OGG1 failed to protect against massive lung edema and BAL cytokines or against depletion of the tissue GSH pool. Interestingly, whereas untreated mice died before completing the 2-h protocol, OGG1-treated mice lived for the duration of observation. Thus mitochondrially targeted OGG1 prevented VILI over a range of ventilation times and pressures and enhanced survival in the most severely injured group. These findings support the concept that oxidative mtDNA damage caused by high PIP triggers induction of acute lung inflammation and injury.

  10. VEGF Production by Ly6C+high Monocytes Contributes to Ventilator-Induced Lung Injury

    PubMed Central

    Lin, Chin-Kuo; Li, Jhy-Ming; Chen, Mei-Hsin; Tsai, Mei-Ling; Chang, Chih-Ching

    2016-01-01

    Background Mechanical ventilation is a life-saving procedure for patients with acute respiratory failure, although it may cause pulmonary vascular inflammation and leakage, leading to ventilator-induced lung injury (VILI). Ly6C+high monocytes are involved in the pathogenesis of VILI. In this study, we investigated whether pulmonary infiltrated Ly6C+high monocytes produce vascular endothelial growth factor (VEGF) and contribute to VILI. Methods A clinically relevant two-hit mouse model of VILI, with intravenous lipopolysaccharide (LPS, 20 ng/mouse) immediately before high tidal volume (HTV, 20 mL/kg) ventilation (LPS+HTV), was established. Blood gas and respiratory mechanics were measured to ensure the development of VILI. Flow cytometry and histopathological analyses revealed pulmonary infiltration of leukocytes subsets. Clodronate liposomes were intravenously injected to deplete pulmonary monocytes. In vitro endothelial cell permeability assay with sorted Ly6C+high monocytes condition media assessed the role of Ly6C+high monocytes in vascular permeability. Results LPS+HTV significantly increased total proteins, TNF-α, IL-6, vascular endothelial growth factor (VEGF) and mononuclear cells in the bronchoalveolar lavage fluid (BALF). Pulmonary Ly6C+high monocytes (SSClowCD11b+F4/80+Ly6C+high), but not Ly6C+low monocytes (SSClowCD11b+F4/80+Ly6C+low), were significantly elevated starting at 4 hr. Clodronate liposomes were able to significantly reduce pulmonary Ly6C+high monocytes, and VEGF and total protein in BALF, and restore PaO2/FiO2. There was a strong correlation between pulmonary Ly6C+high monocytes and BALF VEGF (R2 = 0.8791, p<0.001). Moreover, sorted Ly6C+high monocytes were able to produce VEGF, resulting in an increased permeability of endothelial cell monolayer in an in vitro endothelial cell permeability assay. Conclusion VEGF produced by pulmonary infiltrated Ly6C+high monocytes regulates vasculature permeability in a two-hit model of HTV-induced lung

  11. [Respiratory and extracorporeal lung support].

    PubMed

    Lotz, Christopher; Roewer, Norbert; Muellenbach, Ralf M

    2016-09-01

    Mechanical ventilation is the most commonly used form of respiratory support to restore or maintain adequate gas exchange. However, mechanical ventilation does not provide a physiological form of breathing. Neither does it provide an optimal ventilation / perfusion ratio due to passive movement of the diagphragm favoring the non-dependent parts of the lung. Furthermore, patients are in danger of ventilator-associated/induced lung injury (VALI/VILI). Hence, lung protective ventilation is mandatory in patients with an acute respiratory distress syndrome (ARDS) and should likewise be used in the operating room. Extracorporeal pulmonary support is required in case mechanical ventilation is unable to secure sufficient gas exchange or VILI is imminent. Venovenous extracorporeal membrane oxygenation (vvECMO) acts as lung replacement therapy and may improve survival along with treatment in an ARDS-center. PMID:27631452

  12. Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation.

    PubMed

    Blázquez-Prieto, Jorge; López-Alonso, Inés; Amado-Rodríguez, Laura; Batalla-Solís, Estefanía; González-López, Adrián; Albaiceta, Guillermo M

    2015-10-15

    Inflammation plays a key role in the development of ventilator-induced lung injury (VILI). Preconditioning with a previous exposure can damp the subsequent inflammatory response. Our objectives were to demonstrate that tolerance to VILI can be induced by previous low-pressure ventilation, and to identify the molecular mechanisms responsible for this phenomenon. Intact 8- to 12-wk-old male CD1 mice were preconditioned with 90 min of noninjurious ventilation [peak pressure 17 cmH2O, positive end-expiratory pressure (PEEP) 2 cmH2O] and extubated. Seven days later, preconditioned mice and intact controls were submitted to injurious ventilation (peak pressure 20 cmH2O, PEEP 0 cmH2O) for 2 h to induce VILI. Preconditioned mice showed lower histological lung injury scores, bronchoalveolar lavage albumin content, and lung neutrophilic infiltration after injurious ventilation, with no differences in Il6 or Il10 expression. Microarray analyses revealed a downregulation of Calcb, Hspa1b, and Ccl3, three genes related to tolerance phenomena, in preconditioned animals. Among the previously identified genes, only Ccl3, which encodes the macrophage inflammatory protein 1 alpha (MIP-1α), showed significant differences between intact and preconditioned mice after high-pressure ventilation. In separate, nonconditioned animals, treatment with BX471, a specific blocker of CCR1 (the main receptor for MIP-1α), decreased lung damage and neutrophilic infiltration caused by high-pressure ventilation. We conclude that previous exposure to noninjurious ventilation induces a state of tolerance to VILI. Downregulation of the chemokine gene Ccl3 could be the mechanism responsible for this effect.

  13. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

    SciTech Connect

    Huang, Chien-Sheng; Kawamura, Tomohiro; Peng, Ximei; Tochigi, Naobumi; Shigemura, Norihisa; Billiar, Timothy R.; Nakao, Atsunori; Toyoda, Yoshiya

    2011-05-06

    Highlights: {yields} Hydrogen is a regulatory molecule with antiinflammatory and antiapoptotic protective effects. {yields} There is very limited information on the pathways regulated in vivo by the hydrogen. {yields} Antiapoptotic abilities of hydrogen were explained by upregulation of the antiapoptotic gene. {yields} NF{kappa}B activation during hydrogen treatment was correlated with elevated antiapoptotic protein. {yields} NF{kappa}B activation associated with increase Bcl-2 may contribute to cytoprotection of hydrogen. -- Abstract: We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NF{kappa}B) signaling pathway. VILI was generated in male C57BL6 mice by performing a tracheostomy and placing the mice on a mechanical ventilator (tidal volume of 30 ml/kg or 10 ml/kg without positive end-expiratory pressure). The ventilator delivered either 2% nitrogen or 2% hydrogen in balanced air. NF{kappa}B activation, as indicated by NF{kappa}B DNA binding, was detected by electrophoretic mobility shift assays and enzyme-linked immunosorbent assay. Hydrogen gas inhalation increased NF{kappa}B DNA binding after 1 h of ventilation and decreased NF{kappa}B DNA binding after 2 h of ventilation, as compared with controls. The early activation of NF{kappa}B during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax. Hydrogen inhalation increased oxygen tension, decreased lung edema, and decreased the expression of proinflammatory mediators. Chemical inhibition of early NF{kappa}B activation using SN50 reversed these protective effects. NF{kappa}B activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the

  14. The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Szabari, Margit V.; Miller, Alyssa J.; Hariri, Lida P.; Hamblin, Michael R.; Musch, Guido; Stroh, Helene; Suter, Melissa J.

    2016-03-01

    Although mechanical ventilation (MV) is necessary to support gas exchange in critically ill patients, it can contribute to the development of lung injury and multiple organ dysfunction. It is known that high tidal volume (Vt) MV can cause ventilator-induced lung injury (VILI) in healthy lungs and increase the mortality of patients with Acute Respiratory Distress Syndrome. Low level laser therapy (LLLT) has demonstrated to have anti-inflammatory effects. We investigated whether LLLT could alleviate inflammation from injurious MV in mice. Adult mice were assigned to 2 groups: VILI+LLLT group (3 h of injurious MV: Vt=25-30 ml/kg, respiratory rate (RR)=50/min, positive end-expiratory pressure (PEEP)=0 cmH20, followed by 3 h of protective MV: Vt=9 ml/kg, RR=140/min, PEEP=2 cmH20) and VILI+no LLLT group. LLLT was applied during the first 30 min of the MV (810 nm LED system, 5 J/cm2, 1 cm above the chest). Respiratory impedance was measured in vivo with forced oscillation technique and lung mechanics were calculated by fitting the constant phase model. At the end of the MV, bronchoalveolar lavage (BAL) was performed and inflammatory cells counted. Lungs were removed en-bloc and fixed for histological evaluation. We hypothesize that LLLT can reduce lung injury and inflammation from VILI. This therapy could be translated into clinical practice, where it can potentially improve outcomes in patients requiring mechanical ventilation in the operating room or in the intensive care units.

  15. Intermedin Stabilized Endothelial Barrier Function and Attenuated Ventilator-induced Lung Injury in Mice

    PubMed Central

    Müller-Redetzky, Holger Christian; Kummer, Wolfgang; Pfeil, Uwe; Hellwig, Katharina; Will, Daniel; Paddenberg, Renate; Tabeling, Christoph; Hippenstiel, Stefan; Suttorp, Norbert; Witzenrath, Martin

    2012-01-01

    Background Even protective ventilation may aggravate or induce lung failure, particularly in preinjured lungs. Thus, new adjuvant pharmacologic strategies are needed to minimize ventilator-induced lung injury (VILI). Intermedin/Adrenomedullin-2 (IMD) stabilized pulmonary endothelial barrier function in vitro. We hypothesized that IMD may attenuate VILI-associated lung permeability in vivo. Methodology/Principal Findings Human pulmonary microvascular endothelial cell (HPMVEC) monolayers were incubated with IMD, and transcellular electrical resistance was measured to quantify endothelial barrier function. Expression and localization of endogenous pulmonary IMD, and its receptor complexes composed of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs) 1–3 were analyzed by qRT-PCR and immunofluorescence in non ventilated mouse lungs and in lungs ventilated for 6 h. In untreated and IMD treated mice, lung permeability, pulmonary leukocyte recruitment and cytokine levels were assessed after mechanical ventilation. Further, the impact of IMD on pulmonary vasoconstriction was investigated in precision cut lung slices (PCLS) and in isolated perfused and ventilated mouse lungs. IMD stabilized endothelial barrier function in HPMVECs. Mechanical ventilation reduced the expression of RAMP3, but not of IMD, CRLR, and RAMP1 and 2. Mechanical ventilation induced lung hyperpermeability, which was ameliorated by IMD treatment. Oxygenation was not improved by IMD, which may be attributed to impaired hypoxic vasoconstriction due to IMD treatment. IMD had minor impact on pulmonary leukocyte recruitment and did not reduce cytokine levels in VILI. Conclusions/Significance IMD may possibly provide a new approach to attenuate VILI. PMID:22563471

  16. Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

    PubMed Central

    Camp, Sara M.; Ceco, Ermelinda; Evenoski, Carrie L.; Danilov, Sergei M.; Zhou, Tong; Chiang, Eddie T.; Moreno-Vinasco, Liliana; Mapes, Brandon; Zhao, Jieling; Gursoy, Gamze; Brown, Mary E.; Adyshev, Djanybek M.; Siddiqui, Shahid S.; Quijada, Hector; Sammani, Saad; Letsiou, Eleftheria; Saadat, Laleh; Yousef, Mohammed; Wang, Ting; Liang, Jie; Garcia, Joe G. N.

    2015-01-01

    Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/PBEF). Although VILI severity is attenuated by reduced NAMPT/PBEF bioavailability, the precise contribution of NAMPT/PBEF and excessive mechanical stress to VILI pathobiology is unknown. We now report that NAMPT/PBEF induces lung NFκB transcriptional activities and inflammatory injury via direct ligation of Toll–like receptor 4 (TLR4). Computational analysis demonstrated that NAMPT/PBEF and MD-2, a TLR4-binding protein essential for LPS-induced TLR4 activation, share ~30% sequence identity and exhibit striking structural similarity in loop regions critical for MD-2-TLR4 binding. Unlike MD-2, whose TLR4 binding alone is insufficient to initiate TLR4 signaling, NAMPT/PBEF alone produces robust TLR4 activation, likely via a protruding region of NAMPT/PBEF (S402-N412) with structural similarity to LPS. The identification of this unique mode of TLR4 activation by NAMPT/PBEF advances the understanding of innate immunity responses as well as the untoward events associated with mechanical stress-induced lung inflammation. PMID:26272519

  17. Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress.

    PubMed

    Chen, Weiguo; Epshtein, Yulia; Ni, Xiuquin; Dull, Randal O; Cress, Anne E; Garcia, Joe G N; Jacobson, Jeffrey R

    2015-01-01

    Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin β4 (ITGB4) tyrosine phosphorylation. Accordingly, we hypothesized that endothelial cell (EC) protection by simvastatin is dependent on these effects and sought to further characterize the functional role of ITGB4 as a mediator of EC protection in the setting of excessive mechanical stretch at levels relevant to ventilator-induced lung injury (VILI). Initially, early ITGB4 tyrosine phosphorylation was confirmed in human pulmonary artery EC subjected to excessive cyclic stretch (18% CS). EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). In addition, EC overexpression of ITGB4 constructs with specific structural deletions also resulted in significantly attenuated CS-induced inflammatory cytokine expression compared to overexpression of wildtype ITGB4. Finally, mice expressing a mutant ITGB4 lacking a cytoplasmic signaling domain were found to have attenuated lung injury after VILI-challenge (VT = 40 ml/kg, 4 h). Our results provide mechanistic insights into the anti-inflammatory properties of statins and may ultimately lead to novel strategies targeted at ITGB4 signaling to treat VILI. PMID:26572585

  18. Cockroach fauna in the Ogasawara Chain Islands of Japan and analysis of their habitats.

    PubMed

    Komatsu, Noriyuki; Kishimoto, Toshio; Uchida, Akihiko; Ooi, Hong-Kean

    2013-03-01

    A survey of cockroach fauna was carried out on the 3 inhabited islands of the Ogasawara chain island of Japan, namely, Chichijima island, Hahajima island and Iwo island. Seven species, namely, Periplaneta americana (Linnaeus, 1758), Periplaneta australasiae (Fabricius, 1775), Blattella lituricollis (Walker, 1868), Onychostylus vilis (Brunner von Wattenwyl, 1865), Supella longipalpa (Fabricius, 1798), Pycnoscelus surinamensis (Linnaeus, 1758) and Opisthoplatia orientalis (Burmeister, 1838), were collected on Chichijima island. Four species, namely, P. americana, P. australasiae, O. vilis and P. surinamensis were collected on Hahajima island and 6 species, namely, P. americana, P. australasiae, B. lituricollis, O. vilis, P. surinamensis and Neostylopyga rhombifolia were collected on Iwo island. This is the first record of N. rhombifolia and Onychostylus orientalis on the Ogasawara chain islands. Our study increases the recorded taxon of cockroaches on the Ogasawara from 3 families, 5 genera 10 species to 4 families, 7 genera, 12 species. A list of the cockroach species on Ogasawara islands reported to date as well as a key for their identification is also presented. Periplaneta americana and P. australasiae, being the dominant species, together with S. longipalpa, were collected mostly in the indoor environment, indicating their preference for this habitat. Pycnoscelus surinamensis, which is considered as an outdoor insect has been found in semi-household environments such as greenhouse and shed, indicating their new adaptation to the changing environment.

  19. Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration

    PubMed Central

    Lai, Chih-Cheng; Liu, Wei-Lun; Chen, Chin-Ming

    2014-01-01

    Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer’s solution (vehicle control) thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory. PMID:25100435

  20. The protective effects of glutamine in a rat model of ventilator-induced lung injury

    PubMed Central

    Chen, Chin-Ming; Cheng, Kuo-Chen; Li, Chien-Feng

    2014-01-01

    Background The mortality rate of patients with acute respiratory distress syndrome (ARDS) is still high despite the use of protective ventilatory strategies. We sought to examine the pharmacological effects of glutamine (GLN) in a two-hit model of endotoxin-induced inflammation followed by ventilator-induced lung injury (VILI). We hypothesized that the administration of GLN ameliorates the VILI. Methods Sprague-Dawley rats were anesthetized and given lipopolysaccharide (LPS) intratracheally as a first hit to induce lung inflammation, followed 24 h later by a second hit of mechanical ventilation (MV) with either low tidal volume (6 mL/kg) with 5 cmH2O of positive end-expiratory pressure (PEEP) or high tidal volume (22 mL/kg) with zero PEEP for 4 h. GLN or lactated Ringer’s solution as the placebo was administered intravenously 15 min prior to MV. Results In the LPS-challenged rats ventilated with high tidal volume, the treatment with GLN improved lung injury indices, lung mechanics and cytokine responses compared with the placebo group. Conclusions The administration of GLN given immediately prior to MV may be beneficial in the context of reducing VILI. PMID:25589963

  1. Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

    PubMed

    Rizzo, Alicia N; Sammani, Saad; Esquinca, Adilene E; Jacobson, Jeffrey R; Garcia, Joe G N; Letsiou, Eleftheria; Dudek, Steven M

    2015-12-01

    Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), an illness characterized by life-threatening vascular leak, is a significant cause of morbidity and mortality in critically ill patients. Recent preclinical studies and clinical observations have suggested a potential role for the chemotherapeutic agent imatinib in restoring vascular integrity. Our prior work demonstrates differential effects of imatinib in mouse models of ALI, namely attenuation of LPS-induced lung injury but exacerbation of ventilator-induced lung injury (VILI). Because of the critical role of mechanical ventilation in the care of patients with ARDS, in the present study we pursued an assessment of the effectiveness of imatinib in a "two-hit" model of ALI caused by combined LPS and VILI. Imatinib significantly decreased bronchoalveolar lavage protein, total cells, neutrophils, and TNF-α levels in mice exposed to LPS plus VILI, indicating that it attenuates ALI in this clinically relevant model. In subsequent experiments focusing on its protective role in LPS-induced lung injury, imatinib attenuated ALI when given 4 h after LPS, suggesting potential therapeutic effectiveness when given after the onset of injury. Mechanistic studies in mouse lung tissue and human lung endothelial cells revealed that imatinib inhibits LPS-induced NF-κB expression and activation. Overall, these results further characterize the therapeutic potential of imatinib against inflammatory vascular leak.

  2. Calculations of multiquark functions in effective models of strong interaction

    SciTech Connect

    Jafarov, R. G.; Rochev, V. E.

    2013-09-15

    In this paper we present our results of the investigation of multiquark equations in the Nambu-Jona-Lasinio model with chiral symmetry of SU(2) group in the mean-field expansion. To formulate the mean-field expansion we have used an iteration scheme of solution of the Schwinger-Dyson equations with the fermion bilocal source. We have considered the equations for Green functions of the Nambu-Jona-Lasinio model up to third step for this iteration scheme. To calculate the high-order corrections to the mean-field approximation, we propose the method of the Legendre transformation with respect to the bilocal source, which allows effectively to take into account the symmetry constraints related with the chiral Ward identity. We discuss also the problem of calculating the multiquark functions in the mean-field expansion for Nambu-Jona-Lasinio-type models with other types of the multifermion sources.

  3. [Renowned scientist, pedagogue, and physician dedicated to the memory of the 110th anniversary of Bronius Sidaravicius's birth].

    PubMed

    Laurynaityte, Gryta; Lignugariene, Asta; Valiukeviciene, Skaidra

    2007-01-01

    This year we celebrate the 110th anniversary of Bronius Sidaravicius's (1897-1969) birth. He was a renowned Lithuanian dermato-venereologist, professor, head of the Department of Skin and Venereal Diseases at Vytautas Magnus University (1935-1946, 1956-1969), the founder and the chair of the Lithuanian Society of Dermato-venereologists, coeditor of the prewar journal "Medicina." He is an author of more than 100 articles and the very first course book on dermato-venereology in Lithuanian. He completed a part of his medical studies at universities in Germany. In Vienna University (1930), B. Sidaravicius performed clinical and experimental studies on the passive transmission of skin allergy, which had a major impact on the diagnostics of allergic skin diseases and specific desensibilization. He published the results of his study in the foreign literature and in the doctoral dissertation "Skin allergy and its treatment" in 1931. Thanks to the efforts of B. Sidaravicius and his colleagues, a progressive Law on Control and Prevention of Venereal Diseases was enacted in Lithuania. According to this Law, examinations and treatment of venereal diseases became compulsory and free of charge at state- or municipality-financed venereal outpatient units. This article was prepared on the basis of primary sources: protocols of the Council (the Faculty of Medicine, the University of Lithuania; since 1930 - Vytautas Magnus University) kept at the Museum of the History of Lithuania Medicine and Pharmacy as well as documents preserved at the Lithuanian State Archives and also scientific journals and periodicals both in Lithuanian and foreign languages.

  4. American Journalism Historians Association Annual Convention (London, Ontario, Canada, October 3-5, 1996). Part II: Selecting Papers Covering the 20th Century.

    ERIC Educational Resources Information Center

    American Journalism Historians' Association.

    The 17 papers in this collection all deal with 20th-century journalism, journalists, and mass media. The papers and their authors are: "Building One's Own Gallows: The Trade Publications' Reaction to a Federal Shield Law, 1972-1974" (Karla Gower); "The Useful Ogre: Sweden's Use and Views of American Television, 1956-62" (Ulf Jonas Bjork); "Black…

  5. Gluon condensate in a pion superfluid beyond the mean-field approximation

    SciTech Connect

    Jiang Yin; Zhuang Pengfei

    2011-03-15

    We study gluon condensate in a pion superfluid by calculating the equation of state of the system in the Nambu-Jona-Lasinio model. While in mean-field approximation the growing pion condensate leads to an increasing gluon condensate, meson fluctuations reduce the gluon condensate, and the broken scalar symmetry can be smoothly restored at finite isospin density.

  6. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (75th, Montreal, Quebec, Canada, August 5-8, 1992). Part II: Journalism History, Section B.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    Section B of the Journalism History section of the proceedings contains the following nine papers: "Weep into Silence/Cries of Rage: Bitter Divisions in Hawaii's Japanese Press" (Tom Brislin); "Viewing the Newspaper as International: The First International Organization of Journalists Debates News Copyright 1894-1898" (Ulf Jonas Bjork); "The…

  7. Proceedings of the 1990 Annual Meeting of the Association for Education in Journalism and Mass Communication (73rd, Minneapolis, Minnesota, August 1-4, 1990). Part VI: Foreign and International Media Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The foreign and international media studies section of the proceedings includes the following 11 papers: "The Contemporary Pacific Islands Press" (Suzanna Layton); "Cultural Domination and Sovereignty: The Development of European TV Quotas, 1981-89" (Ulf Jonas Bjork); "A Content Analysis of TV News in Saudi Arabia and Oman" (Abdulrahman I.…

  8. How to dismantle a detonator synapse.

    PubMed

    Pelkey, Kenneth A; McBain, Chris J

    2005-02-01

    Direct electrophysiological evaluation of ion channels in vertebrate presynaptic nerve terminals has been limited to synapses such as the neuromuscular junction and the giant calyx of Held. In this issue of Neuron, Engel and Jonas demonstrate that mossy fiber boutons have specialized voltage-gated Na(+) channels that critically impact upon presynaptic Ca(2+) influx by amplifying terminal invading action potentials.

  9. Ben Jonson: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Barish, Jonas A., Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Jonas A. Barish, T. S. Eliot, L. C. Knights, Harry Levin, Edmund Wilson, Arthur Sale, C. H. Herford, Paul Goodman, Edward B. Partridge, Ray L. Heffner, Jr., Joseph Allen Bryant, Jr., and Dolora Cunningham--all dealing…

  10. 78 FR 32669 - New Approaches to Antibacterial Drug Development; Request for Comments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... study designs, proposed priorities for CDER guidances, and strategies intended to slow the rate of emerging resistance to antibacterial drugs. The purpose of this notice is to request information and..., 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Jonas...

  11. Three Misunderstandings of Plato's Theory of Moral Education

    ERIC Educational Resources Information Center

    Jonas, Mark E.

    2016-01-01

    In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative…

  12. Aspects of the strongly interacting matter phase diagram within non-local quark models

    SciTech Connect

    Pagura, V.; Dumm, D. G.; Scoccola, N. N.

    2013-03-25

    We study a nonlocal extension of the so-called Polyakov Nambu-Jona-Lasinio model at finite temperature and chemical potential, considering the impact of the presence of dynamical quarks on the scale parameter appearing in the Polyakov potential. Both real and imaginary chemical potentials are considered. The effect of varying the current quark mass is also investigated.

  13. A New Problem and the Possible Solution in the Technicoloured Preon Model

    NASA Astrophysics Data System (ADS)

    Matumoto, K.

    1989-02-01

    A version of technicoloured preon model, giving the appropriate order of fermion mass despite the large mass scale of the preonic dynamics of the order of the axion decay constant, is presented, where the dynamics is described by the chiral symmetry breaking solution of the ladder Schwinger-Dyson-Nambu-Jona-Lasinio-hybrid equation.

  14. How Can Video Supported Reflection Enhance Teachers' Professional Development?

    ERIC Educational Resources Information Center

    McCullagh, John F.

    2012-01-01

    This paper responds to Eva Lundqvist, Jonas Almqvist and Leif Ostman's account of how the manner of teaching can strongly influence pupil learning by recommending video supported reflection as a means by which teachers can transform the nature of their practice. Given the complex nature of the many conditions which influence and control teachers'…

  15. Chronic high-magnitude cyclic stretch stimulates EC inflammatory response via VEGF receptor 2-dependent mechanism.

    PubMed

    Gawlak, Grzegorz; Son, Sophia; Tian, Yufeng; O'Donnell, James J; Birukov, Konstantin G; Birukova, Anna A

    2016-06-01

    Ventilator-induced lung injury (VILI) is associated with activated inflammatory signaling, such as cytokine production by endothelial and epithelial cells and macrophages, although the precise mechanisms of inflammatory activation induced by VILI-relevant cyclic stretch (CS) amplitude remain poorly understood. We show that exposure of human pulmonary endothelial cells (EC) to chronic CS at 18% linear distension (18% CS), but not at physiologically relevant 5% CS, induces "EC-activated phenotype," which is characterized by time-dependent increase in ICAM1 and VCAM1 expression. A preconditioning of 18% CS also increased in a time-dependent fashion the release of soluble ICAM1 (sICAM1) and IL-8. Investigation of potential signaling mechanisms of CS-induced EC inflammatory activation showed that 18% CS, but not 5% CS, induced time-dependent upregulation of VEGF receptor 2 (VEGFR2), as monitored by increased protein expression and VEGFR2 tyrosine phosphorylation. Both CS-induced VEGFR2 expression and tyrosine phosphorylation were abrogated by cotreatment with reactive oxygen species inhibitor, N-acetyl cysteine. Molecular inhibition of VEGFR2 expression by gene-specific siRNA or treatment with VEGFR2 pharmacological inhibitor SU-1498 attenuated CS-induced activation of ICAM1 and VCAM1 expression and sICAM1 release. Chronic EC preconditioning at 18% CS augmented EC inflammation and barrier-disruptive response induced by proinflammatory cytokine TNF-α. This effect of chronic 18% CS preconditioning was attenuated by siRNA-induced VEGFR2 knockdown. This study demonstrates for the first time a VEGFR2-dependent mechanism of EC inflammatory activation induced by pathological CS. We conclude that, despite the recognized role of VEGF as a prosurvival and angiogenic factor, excessive activation of VEGFR2 signaling by high-tidal-volume lung mechanical ventilation may contribute to ventilator-induced (biotrauma) lung inflammation and barrier dysfunction by augmenting cell response

  16. Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury

    PubMed Central

    Kuipers, Maria T.; Aslami, Hamid; Vlaar, Alexander P. J.; Juffermans, Nicole P.; Tuip-de Boer, Anita M.; Hegeman, Maria A.; Jongsma, Geartsje; Roelofs, Joris J. T. H.; van der Poll, Tom; Schultz, Marcus J.; Wieland, Catharina W.

    2012-01-01

    Introduction Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Ventilator-induced lung injury (VILI) is mediated by the NLRP3 inflammasome and increased uric acid levels in lung lavage fluid are reported. We studied levels in human lung injury and the contribution of uric acid in experimental VILI. Methods Uric acid levels in lung lavage fluid of patients with acute lung injury (ALI) were determined. In a different cohort of cardiac surgery patients, uric acid levels were correlated with pulmonary leakage index. In a mouse model of VILI the effect of allopurinol (inhibits uric acid synthesis) and uricase (degrades uric acid) pre-treatment on neutrophil influx, up-regulation of adhesion molecules, pulmonary and systemic cytokine levels, lung pathology, and regulation of receptors involved in the recognition of uric acid was studied. In addition, total protein and immunoglobulin M in lung lavage fluid and pulmonary wet/dry ratios were measured as markers of alveolar barrier dysfunction. Results Uric acid levels increased in ALI patients. In cardiac surgery patients, elevated levels correlated significantly with the pulmonary leakage index. Allopurinol or uricase treatment did not reduce ventilator-induced inflammation, IκB-α degradation, or up-regulation of NLRP3, Toll-like receptor 2, and Toll-like receptor 4 gene expression in mice. Alveolar barrier dysfunction was attenuated which was most pronounced in mice pre-treated with allopurinol: both treatment strategies reduced wet/dry ratio, allopurinol also lowered total protein and immunoglobulin M levels. Conclusions Local uric acid levels increase in patients with ALI. In mice, allopurinol and uricase attenuate ventilator-induced alveolar barrier dysfunction. PMID:23226314

  17. Autologous transplantation of adipose-derived stromal cells ameliorates ventilator-induced lung injury in rats

    PubMed Central

    2013-01-01

    Background Adipose-derived stromal cells (ADSCs) are a good alternative to multipotent stem cells for regenerative medicine. Low tidal volume (LVT) has proved to be an effective ventilation strategy. However, it is not known if ADSCs and LVT can protect against ventilator-induced lung injury (VILI). This study was aimed to determine the potential of ADSCs and LVT to repair following VILI and to elucidate the mechanisms responsible for this section. Methods A total of 72 rats were randomly assigned into group I (sham group, n = 18), group II (1 h of high tidal volume-ventilated (HVT) 40 mL/kg to peak airway pressures of approximately 35 cm H2O and 100% oxygen, n = 18), group III (1 h of HVT followed by 6 h LVT 6 mL/kg to peak airway pressures of approximately 6 cm H2O and 100% oxygen, n = 18) and group IV (1 h of HVT followed by intravenous injection of 5 × 106 ADSCs, n = 18). All animals were sacrificed 7 after the experiments lasted for 7 hours. Bronchoalveolar lavage fluid (BALF) was collected and lungs were harvested for analysis. Results High tidal volume-ventilated (HVT) rats exhibited typical VILI features compared with sham rats. Lung edema, histological lung injury index, concentrations of total protein, total cell counts, number of neutrophils in bronchoalveolar lavage fluid (BALF), tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-10 and transforming growth factor-β1 in BALF were significantly increased in HVT rats. Additionally, gene and protein levels of Na+ channel subunits, Na-K-ATPase pump activity and alveolar fluid clearance were significantly decreased in HVT rats. All these indices of VILI were significantly improved in rats treated with ADSCs. However, compared with ADSCs treatment, LVT strategy had little therapeutic effect in the present study. Conclusion These results may provide valuable insights into the effects of ADSCs in acute lung injury. PMID:23890086

  18. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

    PubMed Central

    Tao, Shasha; Rojo de la Vega, Montserrat; Quijada, Hector; Wondrak, Georg T.; Wang, Ting; Garcia, Joe G. N.; Zhang, Donna D.

    2016-01-01

    Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due to lung edema, trauma, or general anesthesia. However, MV causes ventilator-induced lung injury (VILI), a condition characterized by increased permeability of the alveolar-capillary barrier that results in edema, hemorrhage, and neutrophil infiltration, leading to exacerbated lung inflammation and oxidative stress. This study explored the feasibility of using bixin, a canonical NRF2 inducer identified during the current study, to ameliorate lung damage in a murine VILI model. In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo. Remarkably, IP administration of bixin restored normal lung morphology and attenuated inflammatory response and oxidative DNA damage following MV. This observed beneficial effect of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nrf2+/+ but not in Nrf2−/− mice. This is the first study providing proof-of-concept that NRF2 activators can be developed into pharmacological agents for clinical use to prevent patients from lung injury during MV treatment. PMID:26729554

  19. Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury.

    PubMed

    Santana, Maria Cristina E; Garcia, Cristiane S N B; Xisto, Débora G; Nagato, Lilian K S; Lassance, Roberta M; Prota, Luiz Felipe M; Ornellas, Felipe M; Capelozzi, Vera L; Morales, Marcelo M; Zin, Walter A; Pelosi, Paolo; Rocco, Patricia R M

    2009-06-30

    Prone position may delay the development of ventilator-induced lung injury (VILI), but the mechanisms require better elucidation. In experimental mild acute lung injury (ALI), arterial oxygen partial pressure (Pa O2), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1 beta], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally injected while ALI was induced by paraquat. After 24-h, the animals were mechanically ventilated for 1-h in supine or prone positions. In ALI, prone position led to a better blood flow/tissue ratio both in ventral and dorsal regions and was associated with a more homogeneous distribution of alveolar aeration/tissue ratio reducing lung static elastance and viscoelastic pressure, and increasing end-expiratory lung volume and Pa O2. PCIII expression was higher in the ventral than dorsal region in supine position, with no regional changes in inflammatory markers. In conclusion, prone position may protect the lungs against VILI, thus reducing pulmonary stress and strain.

  20. The physical basis of ventilator-induced lung injury

    PubMed Central

    Plataki, Maria; Hubmayr, Rolf D

    2010-01-01

    Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as ventilator-induced lung injury (VILI). The biophysical characteristics of heterogeneously injured ARDS lungs increase the parenchymal stress associated with breathing, which is further aggravated by MV. Cells, in particular those lining the capillaries, airways and alveoli, transform this strain into chemical signals (mechanotransduction). The interaction of reparative and injurious mechanotransductive pathways leads to VILI. Several attempts have been made to identify clinical surrogate measures of lung stress/strain (e.g., density changes in chest computed tomography, lower and upper inflection points of the pressure–volume curve, plateau pressure and inflammatory cytokine levels) that could be used to titrate MV. However, uncertainty about the topographical distribution of stress relative to that of the susceptibility of the cells and tissues to injury makes the existence of a single ‘global’ stress/strain injury threshold doubtful. PMID:20524920

  1. Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

    PubMed Central

    Nelson, Kevin; Bobba, Christopher; Eren, Emre; Spata, Tyler; Tadres, Malak; Hayes,, Don; Black, Sylvester M.

    2015-01-01

    The number of acceptable donor lungs available for lung transplantation is severely limited due to poor quality. Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess organs and expand the donor pool. As this technology expands and improves, the ability to potentially evaluate and improve the quality of substandard lungs prior to transplant is a critical need. In order to more rigorously evaluate these approaches, a reproducible animal model needs to be established that would allow for testing of improved techniques and management of the donated lungs as well as to the lung-transplant recipient. In addition, an EVLP animal model of associated pathologies, e.g., ventilation induced lung injury (VILI), would provide a novel method to evaluate treatments for these pathologies. Here, we describe the development of a rat EVLP lung program and refinements to this method that allow for a reproducible model for future expansion. We also describe the application of this EVLP system to model VILI in rat lungs. The goal is to provide the research community with key information and “pearls of wisdom”/techniques that arose from trial and error and are critical to establishing an EVLP system that is robust and reproducible. PMID:25741794

  2. [The basics on mechanical ventilation support in acute respiratory distress syndrome].

    PubMed

    Tomicic, V; Fuentealba, A; Martínez, E; Graf, J; Batista Borges, J

    2010-01-01

    Acute Respiratory Distress Syndrome (ARDS) is understood as an inflammation-induced disruption of the alveolar endothelial-epithelial barrier that results in increased permeability and surfactant dysfunction followed by alveolar flooding and collapse. ARDS management relies on mechanical ventilation. The current challenge is to determine the optimal ventilatory strategies that minimize ventilator-induced lung injury (VILI) while providing a reasonable gas exchange. The data support that a tidal volume between 6-8 ml/kg of predicted body weight providing a plateau pressure < 30 cmH₂O should be used. High positive end expiratory pressure (PEEP) has not reduced mortality, nevertheless secondary endpoints are improved. The rationale used for high PEEP argues that it prevents cyclic opening and closing of airspaces, probably the major culprit of development of VILI. Chest computed tomography has contributed to our understanding of anatomic-functional distribution patterns in ARDS. Electric impedance tomography is a technique that is radiation-free, but still under development, that allows dynamic monitoring of ventilation distribution at bedside.

  3. Genetic Targets of Hydrogen Sulfide in Ventilator-Induced Lung Injury – A Microarray Study

    PubMed Central

    Spassov, Sashko; Pfeifer, Dietmar; Strosing, Karl; Ryter, Stefan; Hummel, Matthias; Faller, Simone; Hoetzel, Alexander

    2014-01-01

    Recently, we have shown that inhalation of hydrogen sulfide (H2S) protects against ventilator-induced lung injury (VILI). In the present study, we aimed to determine the underlying molecular mechanisms of H2S-dependent lung protection by analyzing gene expression profiles in mice. C57BL/6 mice were subjected to spontaneous breathing or mechanical ventilation in the absence or presence of H2S (80 parts per million). Gene expression profiles were determined by microarray, sqRT-PCR and Western Blot analyses. The association of Atf3 in protection against VILI was confirmed with a Vivo-Morpholino knockout model. Mechanical ventilation caused a significant lung inflammation and damage that was prevented in the presence of H2S. Mechanical ventilation favoured the expression of genes involved in inflammation, leukocyte activation and chemotaxis. In contrast, ventilation with H2S activated genes involved in extracellular matrix remodelling, angiogenesis, inhibition of apoptosis, and inflammation. Amongst others, H2S administration induced Atf3, an anti-inflammatory and anti-apoptotic regulator. Morpholino mediated reduction of Atf3 resulted in elevated lung injury despite the presence of H2S. In conclusion, lung protection by H2S during mechanical ventilation is associated with down-regulation of genes related to oxidative stress and inflammation and up-regulation of anti-apoptotic and anti-inflammatory genes. Here we show that Atf3 is clearly involved in H2S mediated protection. PMID:25025333

  4. Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies.

    PubMed

    Hopster, K; Jacobson, B; Hopster-Iversen, C; Rohn, K; Kästner, S B R

    2016-08-01

    Inappropriate mechanical ventilation can lead to ventilator-induced lung injury (VILI). Aim of this study was to evaluate the effects of inhalation anaesthesia and ventilation with and without recruitment (RM) and PEEP titration on alveolar integrity in horses. Twenty-three horses were divided into 4 groups (group OLC ventilated with OLC, group IPPV ventilated with intermittent positive pressure ventilation, group NV non-ventilated, and group C non-anaesthetized control group). After sedation with xylazine and induction with diazepam and ketamine anaesthetized horses were under isoflurane anaesthesia for 5.5h. The horses were euthanized and tissue samples of the dependent and non-dependent lung areas were collected. Histopathological examinations of the lung tissue as well as relative quantification of mRNA of IL-1β, IL-6, iNOS, MMP1 and MMP9 by PCR were performed. Horses of group OLC had significantly less alveolar congestion and atelectasis but greater alveolar overdistension compared to groups NV and IPPV. In groups OLC and group IPPV an increase in IL-1β/6 and MMP1/9 was detected compared to groups NV and C. In conclusion, in breathing spontaneously or IPPV-ventilated horses a higher degree of atelectasis was detected, whereas in OLC-ventilated horses a higher degree of overdistention was present. Elevated levels in IL and MMP might be early signs of VILI in ventilated horses. PMID:27473968

  5. Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury

    PubMed Central

    2010-01-01

    Background Although mechanical ventilation (MV) is a major supportive therapy for patients with acute respiratory distress syndrome, it may result in side effects including lung injury. In this study we hypothesize that MMP-9 inhibition by doxycycline might reduce MV-related lung damage. Using a proteomic approach we identified the pulmonary proteins altered in high volume ventilation-induced lung injury (VILI). Forty Wistar rats were randomized to an orally pretreated with doxycycline group (n = 20) or to a placebo group (n = 20) each of which was followed by instrumentation prior to either low or high tidal volume mechanical ventilation. Afterwards, animals were euthanized and lungs were harvested for subsequent analyses. Results Mechanical function and gas exchange parameters improved following treatment with doxycycline in the high volume ventilated group as compared to the placebo group. Nine pulmonary proteins have shown significant changes between the two biochemically analysed (high volume ventilated) groups. Treatment with doxycycline resulted in a decrease of pulmonary MMP-9 activity as well as in an increase in the levels of soluble receptor for advanced glycation endproduct, apoliporotein A-I, peroxiredoxin II, four molecular forms of albumin and two unnamed proteins. Using the pharmacoproteomic approach we have shown that treatment with doxycycline leads to an increase in levels of several proteins, which could potentially be part of a defense mechanism. Conclusion Administration of doxycycline might be a significant supportive therapeutic strategy in prevention of VILI. PMID:20205825

  6. Phase diagram of quark-antiquark and diquark condensates in the 3-dimensional Gross-Neveu model with the 4-component spinor representation

    SciTech Connect

    Kohyama, Hiroaki

    2008-07-01

    We construct the phase diagram of the quark-antiquark and diquark condensates at finite temperature and density in the 2+1 dimensional (3D) two flavor massless Gross-Neveu (GN) model with the 4-component quarks. In contrast to the case of the 2-component quarks, there appears the coexisting phase of the quark-antiquark and diquark condensates. This is the crucial difference between the 2-component and 4-component quark cases in the 3D GN model. The coexisting phase is also seen in the 4D Nambu Jona-Lasinio model. Then we see that the 3D GN model with the 4-component quarks bears closer resemblance to the 4D Nambu Jona-Lasinio model.

  7. What does low energy physics tell us about the zero momentum gluon propagator?

    SciTech Connect

    Costa, P.; Oliveira, O.; Silva, P. J.

    2011-05-23

    The connection between QCD, a nonlocal Nambu-Jona-Lasinio type model and the Landau gauge gluon propagator is explored. This two point function is parameterized by a functional form which is compatible with Dyson-Schwinger and lattice QCD results. Demanding the nonlocal model to reproduce the experimental values for the pion mass, the pion decay constant, {Gamma}{sub {pi}{yields}{gamma}{gamma}} and the light quark condensate we conclude that low energy physics does not distinguish between the so-called decoupling and scaling solutions of the Dyson-Schwinger equations. This result means that, provided that the model parameters are chosen appropriately, one is free to choose any of the above scenarios. Furthermore, the nonlocal Nambu-Jona-Lasinio quark model considered here is chiral invariant and satisfies the GMOR relation at the 1% level of precision.

  8. Quark confinement in a constituent quark model

    SciTech Connect

    Langfeld, K.; Rho, M.

    1995-07-01

    On the level of an effective quark theory, we define confinement by the absence of quark anti-quark thresholds in correlation function. We then propose a confining Nambu-Jona-Lasinio-type model. The confinement is implemented in analogy to Anderson localization in condensed matter systems. We study the model`s phase structure as well as its behavior under extreme conditions, i.e. high temperature and/or high density.

  9. Investigation of possible structures of hybrid neutron stars

    SciTech Connect

    Paoli, M. G.; Menezes, D. P.

    2010-11-12

    This work investigates the structure of hybrid stars built in two different ways. The first one considers the existence of a mixed phase at intermediate stellar densities. The second implies the inexistence of this mixed phase. In this case, the hadron phase and the quark phase are in direct contact. We use the non-linear Walecka model (NLWM) to describe the hadron phase and the Nambu-Jona-Lasinio model (NJL) for the quark phase.

  10. The phases of isospin asymmetric matter in the two flavor NJL model

    SciTech Connect

    S. Lawley; W. Bentz; A. W. Thomas

    2005-04-01

    We investigate the phase diagram of isospin asymmetric matter at T=0 in the two flavor Nambu-Jona-Lasinio model. Our approach describes the single nucleon as a quark-diquark bound state, the saturation properties of nuclear matter at normal densities, and the phase transition to normal or color superconducting quark matter at higher densities. The resulting equation of state of charge neutral matter is discussed.

  11. Chemical prosthesis.

    PubMed

    Zenico, T; Zoli, M; Maltoni, G

    1989-01-01

    The approach to patients suffering from erectile failure includes medical and sexual anamnesis, Doppler ultrasound, Jonas erectiometer and Sacral Latency Test. At present, the use of papaverine directly in corpora cavernosa seems indicated in performance anxiety dysfunctions used together with psycotherapy and in slight arterial deficiencies, diabetes, after destructive pelvic surgery and in neurological lesions. From January 1986 we have performed 150 I.C. injections of papaverine. Experience in 60 patients is described. Seven patients are now self-injecting.

  12. From inverse to delayed magnetic catalysis in a strong magnetic field

    NASA Astrophysics Data System (ADS)

    Mao, Shijun

    2016-08-01

    We study the magnetic field effect on chiral phase transition in a Nambu-Jona-Lasinio model. In comparison with a mean-field approximation containing only quarks, including mesons as quantum fluctuations in the model leads to a transition from inverse to delayed magnetic catalysis at finite temperature and delays the transition at finite baryon chemical potential. The location of the critical end point depends nonmonotonically on the magnetic field.

  13. Variance analysis. Part II, The use of computers.

    PubMed

    Finkler, S A

    1991-09-01

    This is the second in a two-part series on variance analysis. In the first article (JONA, July/August 1991), the author discussed flexible budgeting, including the calculation of price, quantity, volume, and acuity variances. In this second article, the author focuses on the use of computers by nurse managers to aid in the process of calculating, understanding, and justifying variances. PMID:1919788

  14. Determinations of the non-recrystallization temperature for X52 steel produced by compact slab process combined with direct hot rolling

    NASA Astrophysics Data System (ADS)

    Zaky, Ahmed Ismail

    2006-12-01

    Deformation comprises not only dimensional accuracy but also the control of the final microstructure and mechanical properties. Deformation below the non-recrystallization temperature ( T nr) is important to design the proper rolling schedule to avoid grain growth in the final stages of rolling. The determination of T nr for Nb-bearing carbon steel with a compact slab process mill log is carried out depending upon the Misaka concept calculation. A comparison among different formulas for predicting the T nr was conducted using Misaka, Bratto, and Jonas equations. The Misaka equation depends on the chemical compositions and deformation parameters including dynamic and metadynamic recrystallization. The Bratto equation considers only the steel chemical composition. The Jonas equation depends only on the accumulated strain. The Bratto equation gives a large value of T nr, while the Misaka equations show a moderate and accurate value in relation to the Jonas results, which depend on torsion tests. The effect of strain accumulation on dynamic recrystallization is investigated to predict the final grain size of ferrite.

  15. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

    PubMed

    Henriques, Isabela; Padilha, Gisele A; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J B; Ramos, Isalira P; Rocha, Nazareth; Cruz, Fernanda F; Santos, Raquel S; de Oliveira, Milena V; Souza, Sergio A; Goldenberg, Regina C; Luiz, Ronir R; Pelosi, Paolo; de Abreu, Marcelo G; Silva, Pedro L; Rocco, Patricia R M

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  16. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

    PubMed

    Henriques, Isabela; Padilha, Gisele A; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J B; Ramos, Isalira P; Rocha, Nazareth; Cruz, Fernanda F; Santos, Raquel S; de Oliveira, Milena V; Souza, Sergio A; Goldenberg, Regina C; Luiz, Ronir R; Pelosi, Paolo; de Abreu, Marcelo G; Silva, Pedro L; Rocco, Patricia R M

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  17. Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy

    PubMed Central

    2012-01-01

    Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pneumonectomy, mechanical ventilation with tidal volumes (VT) of 6 mL/kg and FiO2 0.5, and were subsequently randomized to a protectively ventilated group (PROTV; n = 8) keeping VT and FiO2 unchanged, respiratory rate (RR) 25 inflations/min and PEEP 4 cm H2O for the following 8 hrs; an injuriously ventilated group with VT of 12 mL/kg, zero end-expiratory pressure, and FiO2 and RR unchanged (INJV; n = 8) and a group, which additionally received the inhibitor of nNOS, 7-nitroindazole (NI) 1.0 mg/kg/h intravenously from 2 hours after the commencement of injurious ventilation (INJV + NI; n = 8). We assessed respiratory, hemodynamic and volumetric variables, including both the extravascular lung water index (EVLWI) and the pulmonary vascular permeability index (PVPI). We measured plasma nitrite/nitrate (NOx) levels and examined lung biopsies for lung injury score (LIS). Results Both the injuriously ventilated groups demonstrated a 2–3-fold rise in EVLWI and PVPI, with no significant effects of NI. In the INJV group, gas exchange deteriorated in parallel with emerging respiratory acidosis, but administration of NI antagonized the derangement of oxygenation and the respiratory acidosis significantly. NOx displayed no significant changes and NI exerted no significant effect on LIS in the INJV group. Conclusion Inhibition of nNOS improved gas exchange, but did not

  18. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema

    PubMed Central

    Henriques, Isabela; Padilha, Gisele A.; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J. B.; Ramos, Isalira P.; Rocha, Nazareth; Cruz, Fernanda F.; Santos, Raquel S.; de Oliveira, Milena V.; Souza, Sergio A.; Goldenberg, Regina C.; Luiz, Ronir R.; Pelosi, Paolo; de Abreu, Marcelo G.; Silva, Pedro L.; Rocco, Patricia R. M.

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  19. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome.

    PubMed

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  20. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

    NASA Astrophysics Data System (ADS)

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F.; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  1. [Perspective of cervical cancer prevention and control in developing countries and areas].

    PubMed

    Qiao, You-Lin

    2010-01-01

    Cervical cancer ranks the second common cancer in women, affecting women severely in developing countries. It is a critical issue to develop simple, rapid, accurate, safe, acceptable, and inexpensive screening tests which can be used in cervical cancer prevention programs in developing countries. Due to the shortage of funding and qualified cytological professionals in most developing countries, WHO has been actively promoting visual inspection with acetic acid/iodine solution (VIA/VILI) as the alternative approach to screening cervical cancer. After the discovery of a link between human papillomavirus (HPV) and cervical cancer, the HPV prophylactic vaccine and CareHPV test have been successfully developed. The cervical cancer will be the first cancer eliminated by the combination of vaccination, screening, early diagnosis and treatment.

  2. Bronchoalveolar hemostasis in lung injury and acute respiratory distress syndrome.

    PubMed

    Glas, G J; Van Der Sluijs, K F; Schultz, M J; Hofstra, J-J H; Van Der Poll, T; Levi, M

    2013-01-01

    Enhanced intrapulmonary fibrin deposition as a result of abnormal broncho-alveolar fibrin turnover is a hallmark of acute respiratory distress syndrome (ARDS), pneumonia and ventilator-induced lung injury (VILI), and is important to the pathogenesis of these conditions. The mechanisms that contribute to alveolar coagulopathy are localized tissue factor-mediated thrombin generation, impaired activity of natural coagulation inhibitors and depression of bronchoalveolar urokinase plasminogen activator-mediated fibrinolysis, caused by the increase of plasminogen activator inhibitors. There is an intense and bidirectional interaction between coagulation and inflammatory pathways in the bronchoalveolar compartment. Systemic or local administration of anticoagulant agents (including activated protein C, antithrombin and heparin) and profibrinolytic agents (such as plasminogen activators) attenuate pulmonary coagulopathy. Several preclinical studies show additional anti-inflammatory effects of these therapies in ARDS and pneumonia. PMID:23114008

  3. μ-PIV/Shadowgraphy measurements to elucidate dynamic physicochemical interactions in a multiphase model of pulmonary airway reopening

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Eiichiro

    2010-10-01

    We employ micro-particle image velocimetry (μ-PIV) and shadowgraphy to measure the ensemble-averaged fluid-phase velocity field and interfacial geometry during pulsatile bubble propagation that includes a reverse-flow phase under influence of exogenous lung surfactant (Infasurf). Disease states such as respiratory distress syndrome (RDS) are characterized by insufficient pulmonary surfactant concentrations that enhance airway occlusion and collapse. Subsequent airway reopening, driven by mechanical ventilation, may generate damaging stresses that cause ventilator-induced lung injury (VILI). It is hypothesized that reverse flow may enhance surfactant uptake and protect the lung from VILI. The microscale observations conducted in this study will provide us with a significant understanding of dynamic physicochemical interactions that can be manipulated to reduce the magnitude of this damaging mechanical stimulus during airway reopening. Bubble propagation through a liquid-occluded fused glass capillary tube is controlled by linear-motor-driven syringe pumps that provide mean and sinusoidal velocity components. A translating microscope stage mechanically subtracts the mean velocity of the bubble tip in order to hold the progressing bubble tip in the microscope field of view. To optimize the signal-to-noise ratio near the bubble tip, μ-PIV and shadow images are recorded in separate trials then combined during post-processing with help of a custom-designed micro scale marker. Non-specific binding of Infasurf proteins to the channel wall is controlled by oxidation and chemical treatment of the glass surface. The colloidal stability and dynamic/static surface properties of the Infasurf-PIV particle solution are carefully adjusted based on Langmuir trough measurements. The Finite Time Lyapunov Exponent (FTLE) is computed to provide a Lagrangian perspective for comparison with our boundary element predictions.

  4. Influence of mechanical ventilation and sepsis on redox balance in diaphragm, myocardium, limb muscles, and lungs.

    PubMed

    Chacon-Cabrera, Alba; Rojas, Yeny; Martínez-Caro, Leticia; Vila-Ubach, Monica; Nin, Nicolas; Ferruelo, Antonio; Esteban, Andrés; Lorente, José A; Barreiro, Esther

    2014-12-01

    Mechanical ventilation (MV), using high tidal volumes (V(T)), causes lung (ventilator-induced lung injury [VILI]) and distant organ injury. Additionally, sepsis is characterized by increased oxidative stress. We tested whether MV is associated with enhanced oxidative stress in sepsis, the commonest underlying condition in clinical acute lung injury. Protein carbonylation and nitration, antioxidants, and inflammation (immunoblotting) were evaluated in diaphragm, gastrocnemius, soleus, myocardium, and lungs of nonseptic and septic (cecal ligation and puncture 24 hours before MV) rats undergoing MV (n = 7 per group) for 150 minutes using 3 different strategies (low V(T) [V(T) = 9 mL/kg], moderate V(T) [V(T) = 15 mL/kg], and high V(T) [V(T) = 25 mL/kg]) and in nonventilated control animals. Compared with nonventilated control animals, in septic and nonseptic rodents (1) diaphragms, limb muscles, and myocardium of high-V(T) rats exhibited a decrease in protein oxidation and nitration levels, (2) antioxidant levels followed a specific fiber-type distribution in slow- and fast-twitch muscles, (3) tumor necrosis factor α (TNF-α) levels were higher in respiratory and limb muscles, whereas no differences were observed in myocardium, and (4) in lungs, protein oxidation was increased, antioxidants were rather decreased, and TNF-α remained unmodified. In this model of VILI, oxidative stress does not occur in distant organs or skeletal muscles of rodents after several hours of MV with moderate-to-high V(T), whereas protein oxidation levels were increased in the lungs of the animals. Inflammatory events were moderately expressed in skeletal muscles and lungs of the MV rats. Concomitant sepsis did not strongly affect the MV-induced effects on muscles, myocardium, or lungs in the rodents.

  5. High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study

    PubMed Central

    2011-01-01

    Background To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses. Methods Rats were challenged by acid instillation or 24 h of sepsis induced by cecal ligation and puncture, followed by mechanical ventilation (MV) with either a low tidal volume (Vt) of 6 mL/kg and 5 cm H2O positive end-expiratory pressure (PEEP; LVt acid, LVt sepsis) or with a high Vt of 15 mL/kg and no PEEP (HVt acid, HVt sepsis). Rats sacrificed immediately after acid instillation and non-ventilated septic animals served as controls. Hemodynamic and respiratory variables were monitored. After 4 h, lung wet to dry (W/D) weight ratios, histological lung injury and plasma mediator concentrations were measured. Results Oxygenation and lung compliance decreased after acid instillation as compared to sepsis. Additionally, W/D weight ratios and histological lung injury scores increased after acid instillation as compared to sepsis. MV increased W/D weight ratio and lung injury score, however this effect was mainly attributable to HVt ventilation after acid instillation. Similarly, effects of HVt on oxygenation were only observed after acid instillation. HVt during sepsis did not further affect oxygenation, compliance, W/D weight ratio or lung injury score. Plasma interleukin-6 and tumour necrosis factor-α concentrations were increased after acid instillation as compared to sepsis, but plasma intercellular adhesion molecule-1 concentration increased during sepsis only. In contrast to lung injury parameters, no additional effects of HVt MV after acid instillation on plasma mediator concentrations were observed. Conclusions During MV more severe lung injury develops after acid instillation as compared to sepsis. HVt causes VILI after acid instillation, but not during sepsis. However, this differential effect was not observed in the systemic release of mediators. PMID:22204611

  6. Nicotinamide Exacerbates Hypoxemia in Ventilator-Induced Lung Injury Independent of Neutrophil Infiltration

    PubMed Central

    Jones, Heather D.; Yoo, Jeena; Crother, Timothy R.; Kyme, Pierre; Ben-Shlomo, Anat; Khalafi, Ramtin; Tseng, Ching W.; Parks, William C.; Arditi, Moshe

    2015-01-01

    Background Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3) directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury. Methods We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts, protein, and cytokine levels. We also measured expression of nicotinamide phosophoribosyltransferase, and its downstream effectors Sirt1 and Cebpa, Cebpb, Cebpe. We assessed the effect of nicotinamide on the production of nitric oxide during ventilator-induced lung injury. We also studied the effects of ventilator-induced lung injury in mice deficient in C/EBPε. Results Nicotinamide treatment significantly inhibited neutrophil infiltration into the lungs during ventilator-induced lung injury, but did not affect protein leakage or cytokine production. Surprisingly, mice treated with nicotinamide developed significantly worse hypoxemia during mechanical ventilation. This effect was not linked to increases in nitric oxide production or alterations in expression of Nicotinamide phosphoribosyl transferase, Sirt1, or Cebpa and Cebpb. Cebpe mRNA levels were decreased with either nicotinamide treatment or mechanical ventilation, but mice lacking C/EBPε developed the same degree of hypoxemia and ventilator-induced lung injury as wild-type mice. Conclusions Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but

  7. Nonperturbative explanation of the enhancement factors in the QCD sum rule for the {rho} meson

    SciTech Connect

    Nie, S.; Kuang, Y.; Wang, Q.; Yi, Y. |

    1997-08-01

    Taking the sum rule for the {rho} meson as an example, we study the possibility of explaining the phenomenological enhancement factors for certain terms in the vacuum expectation value of operator product expansion in the QCD sum rule. We take a QCD motivated extended Nambu{endash}Jona-Lasinio model as the low energy effective Lagrangian for QCD with which we calculate the nonperpturbative contributions to the vaccum condensate expansion to obtain the enhancement factors. Our result shows that such nonperturbative contributions can cause large enough enhancement factors which can be consistent with the phenomenological values. {copyright} {ital 1997} {ital The American Physical Society}

  8. Responses of quark condensates to the chemical potential

    NASA Astrophysics Data System (ADS)

    Miyamura, O.; Choe, S.; Liu, Y.; Takaishi, T.; Nakamura, A.

    2002-10-01

    The responses of quark condensates to the chemical potential, as a function of temperature T and chemical potential μ, are calculated within the Nambu-Jona-Lasinio (NJL) model. We compare our results with those from the recent lattice QCD simulations [QCD-TARO Collaboration, S. Choe et al., Nucl. Phys. B (Proc. Suppl.) 106, 462 (2002)]. The NJL model and lattice calculations show qualitatively similar behavior, and they will be complimentary ways to study hadrons at finite density. The behavior above Tc requires more elaborated analyses.

  9. Transversity form factors of the pion in chiral quark models

    SciTech Connect

    Broniowski, Wojciech; Dorokhov, Alexander E.; Arriola, Enrique Ruiz

    2010-11-01

    The transversity form factors of the pion, involving matrix elements of bilocal tensor currents, are evaluated in chiral quark models, both in the local Nambu-Jona-Lasinio with the Pauli-Villars regularization, as well as in nonlocal models involving momentum-dependent quark mass. After suitable QCD evolution, the agreement with recent lattice calculations is very good, in accordance to the fact that the spontaneously broken chiral symmetry governs the dynamics of the pion. Meson dominance of form factors with expected meson masses also works properly, conforming to the parton-hadron duality in the considered process.

  10. Universal cumulants of the current in diffusive systems on a ring.

    PubMed

    Appert-Rolland, C; Derrida, B; Lecomte, V; van Wijland, F

    2008-08-01

    We calculate exactly the first cumulants of the integrated current and of the activity (which is the total number of changes of configurations) of the symmetric simple exclusion process on a ring with periodic boundary conditions. Our results indicate that for large system sizes the large deviation functions of the current and of the activity take a universal scaling form, with the same scaling function for both quantities. This scaling function can be understood either by an analysis of Bethe ansatz equations or in terms of a theory based on fluctuating hydrodynamics or on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim. PMID:18850801

  11. Chiral symmetry, constituent quarks and quasi-elastic electron-nucleus scattering

    NASA Astrophysics Data System (ADS)

    Henley, E. M.; Krein, G.

    1989-11-01

    The effects of chiral symmetry breaking are examined for quasi-elastic electron scattering on nuclei. Nucleons are assumed to be composed of constituent quarks with masses that depend on density. This density dependence is determined on the basis of the Nambu-Jona-Lasinio model. It is found that the effects of chiral symmetry breaking are in the right direction and the right order of magnitude to explain the discrepancies between theory and experiment. On leave from Departamento de Fisica, Universidade Federal de Santa Maria, 97100 Santa Maria, R.S., Brazil.

  12. Baryon octet electromagnetic form factors in a confining NJL model

    NASA Astrophysics Data System (ADS)

    Carrillo-Serrano, Manuel E.; Bentz, Wolfgang; Cloët, Ian C.; Thomas, Anthony W.

    2016-08-01

    Electromagnetic form factors of the baryon octet are studied using a Nambu-Jona-Lasinio model which utilizes the proper-time regularization scheme to simulate aspects of colour confinement. In addition, the model also incorporates corrections to the dressed quarks from vector meson correlations in the t-channel and the pion cloud. Comparison with recent chiral extrapolations of lattice QCD results shows a remarkable level of consistency. For the charge radii we find the surprising result that rEp < rEΣ+ and | rEn | < | rEΞ0 |, whereas the magnetic radii have a pattern largely consistent with a naive expectation based on the dressed quark masses.

  13. Chiral phase transition from string theory.

    PubMed

    Parnachev, Andrei; Sahakyan, David A

    2006-09-15

    The low energy dynamics of a certain D-brane configuration in string theory is described at weak t'Hooft coupling by a nonlocal version of the Nambu-Jona-Lasinio model. We study this system at finite temperature and strong t'Hooft coupling, using the string theory dual. We show that for sufficiently low temperatures chiral symmetry is broken, while for temperatures larger then the critical value, it gets restored. We compute the latent heat and observe that the phase transition is of the first order.

  14. Impact of a magnetic field on the thermodynamics of magnetized quark matter

    NASA Astrophysics Data System (ADS)

    Farias, R. L. S.; Timóteo, V. S.; Avancini, S.; Pinto, M. B.; Krein, G.

    2016-04-01

    We investigate the effect of a magnetic field on the thermodynamics of magnetized quark matter at finite temperature. By using the Nambu Jona-Lasino (NJL) model, we show that the lattice results for the quark consensate can be reproduced when the coupling constant G of the model decreases with the magnetic field and the temperature. Our results show that thermodynamic quantities and quark condensates are very sensitive to the dependence of G with the temperature, even in the absence of a magnetic field.

  15. Transversity quark distributions in a covariant quark-diquark model

    SciTech Connect

    I.C. Cloet; W. Bentz; A.W. Thomas

    2008-01-01

    Transversity quark light-cone momentum distributions are calculated for the nucleon. We utilize a modified Nambu--Jona-Lasinio model in which confinement is simulated by eliminating unphysical thresholds for nucleon decay into quarks. The nucleon bound state is obtained by solving the relativistic Faddeev equation in the quark-diquark approximation, where both scalar and axial-vector diquark channels are included. Particular attention is paid to comparing our results with the recent experimental extraction of the transversity distributions by Anselmino et al. We also compare our transversity results with earlier spin-independent and helicity quark distributions calculated in the same approach.

  16. Magnetized color superconducting cold quark matter within the SU(2 ) f NJL model: A novel regularization scheme

    NASA Astrophysics Data System (ADS)

    Allen, P.; Grunfeld, A. G.; Scoccola, N. N.

    2015-10-01

    The influence of intense magnetic fields on the behavior of color superconducting cold quark matter is investigated using an SU(2 ) f Nambu-Jona-Lasinio-type model for which a novel regulation scheme is introduced. In such a scheme the contributions which are explicitly dependent on the magnetic field turn out to be finite and, thus, do not require to be regularized. As a result of this, nonphysical oscillations that might arise in the alternative regularization schemes previously used in the literature are naturally removed. In this way, a clearer interpretation of the physical oscillations is possible. The sensitivity of our results to the model parametrization is analyzed.

  17. [The biologization of ethics].

    PubMed

    Moreno Lax, Alejandro

    2010-01-01

    Three ethics exist as a condition of possibility of any possible ethics, following a material and biological foundation. This content argument (not logical-formal) supposes a refutation of the naturalistic fallacy that the analytical philosophy attributes to Hume, in three areas of the ethical human experience: body, society and nature. These are: the ethics of the species [J. Habermas], the ethics of liberation [E. Dussel] and the ethics of the responsibility [H. Jonas]. This material argument is a philosophical foundation to considering for three types of applied ethics: medical bioethics, development ethics and environmental ethics.

  18. Phase structure in a chiral model of nuclear matter

    SciTech Connect

    Phat, Tran Huu; Anh, Nguyen Tuan; Tam, Dinh Thanh

    2011-08-15

    The phase structure of symmetric nuclear matter in the extended Nambu-Jona-Lasinio (ENJL) model is studied by means of the effective potential in the one-loop approximation. It is found that chiral symmetry gets restored at high nuclear density and a typical first-order phase transition of the liquid-gas transition occurs at zero temperature, T=0, which weakens as T grows and eventually ends up with a second-order critical point at T=20 MeV. This phase transition scenario is confirmed by investigating the evolution of the effective potential versus the effective nucleon mass and the equation of state.

  19. Magnet hospitals: Part II. Institutions of excellence.

    PubMed

    Kramer, M; Schmalenberg, C

    1988-02-01

    The oft repeated charge today is to "focus on those who are succeeding!" That's what this report does. Using the eight characteristics identified by Peters and Waterman in their book In Search of Excellence, the study analyzes 16 magnet hospitals to ascertain to what extent they possess characteristics similar to the 'best run' companies in the corporate community. The authors suggest that these magnet hospitals may be dealing effectively with the nursing shortage by creating organizational conditions conducive to eliminating internal nurse shortage. Part I of this article appeared the January 1988 issue of JONA.

  20. Correlations of a quasi-two-dimensional dipolar ultracold gas at finite temperatures

    NASA Astrophysics Data System (ADS)

    Pawłowski, Krzysztof; Bienias, Przemysław; Pfau, Tilman; Rzążewski, Kazimierz

    2013-04-01

    We study a quasi-two-dimensional dipolar gas at finite, but ultralow, temperatures using the classical field approximation. The method, already used for a contact interacting gas, is extended here to samples with a weakly interacting long-range interatomic potential. We present statistical properties of the system for the current experiment with chromium [Müller, Billy, Henn, Kadau, Griesmaier, Jona-Lasinio, Santos, and Pfau, Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.84.053601 84, 053601 (2011)] and compare them with statistics for atoms with larger magnetic dipole moments. Significant enhancement of the third-order correlation function, relevant for the particle losses, is found.

  1. Entanglement between the Deconfinement and the Chiral Symmetry Restoration

    SciTech Connect

    Sakai, Yuji; Sasaki, Takahiro; Yahiro, Masanobu; Kouno, Hiroaki

    2011-10-21

    We extend the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model by introducing an effective four-quark vertex depending on the Polyakov loop. The effective vertex generates entanglement interactions between the Polyakov loop and the chiral condensate. The new model is consistent with lattice QCD data at imaginary quark-number chemical potential and real and imaginary isospin chemical potentials. We investigate the influence of the entanglement interactions on the location of the critical endpoint at real quark-number chemical potential.

  2. [Crisis in medical ethics].

    PubMed

    Stellamor, K

    1996-01-01

    There is a disproportion between diagnostic and therapeutic medical achievements and the doctor/patient relationship. Are we allowed to do everything we are able to do in medicine? People are concerned and worried (genetic technology, invasive medicine, embryos in test tubes etc.). The crisis of ethics in medicine is evident. The analysis of the situation shows one of the causes in the shift of the paradigma-modern times to postmodern following scientific positivism-but also a loss of ethics in medicine due to an extreme secularism and to modern philosophical trends (Hans Jonas and the responsibility for the future and on the other hand modern utilitarism). PMID:9036685

  3. [Crisis in medical ethics].

    PubMed

    Stellamor, K

    1996-01-01

    There is a disproportion between diagnostic and therapeutic medical achievements and the doctor/patient relationship. Are we allowed to do everything we are able to do in medicine? People are concerned and worried (genetic technology, invasive medicine, embryos in test tubes etc.). The crisis of ethics in medicine is evident. The analysis of the situation shows one of the causes in the shift of the paradigma-modern times to postmodern following scientific positivism-but also a loss of ethics in medicine due to an extreme secularism and to modern philosophical trends (Hans Jonas and the responsibility for the future and on the other hand modern utilitarism).

  4. Quark fragmentation functions in NJL-jet model

    NASA Astrophysics Data System (ADS)

    Bentz, Wolfgang; Matevosyan, Hrayr; Thomas, Anthony

    2014-09-01

    We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. Supported by Grant in Aid for Scientific Research, Japanese Ministry of Education, Culture, Sports, Science and Technology, Project No. 20168769.

  5. Equations of state and stability of color-superconducting quark matter cores in hybrid stars

    SciTech Connect

    Agrawal, B. K.

    2010-01-15

    The stable configurations of nonrotating and rotating hybrid stars composed of color-superconducting quark matter cores are constructed using several equations of state (EOSs). We use a set of diverse EOSs for the nuclear matter which represents the low density phase. The EOSs at higher densities correspond to the quark matter in the color-superconducting phase and are computed within the Nambu-Jona-Lasinio-like model for different values of the scalar diquark and vector current couplings strengths. The phase transition to the quark matter is computed by a Maxwell construction. We find that the stability of the hybrid stars are mainly governed by the behavior of the EOSs for the color-superconducting quark matter. However the compositions of hybrid stars are sensitive to the EOS of the nuclear matter. The value of the critical rotation frequency for the hybrid star depends strongly on the EOS of the nuclear matter as well as that for the color-superconducting quark matter. Our results indicate that the EOS for the color-superconducting quark matter can be obtained, by adjusting the parameters of the Nambu-Jona-Lasinio model, to yield the stable configurations of the hybrid star having the maximum mass {approx}1.5M{sub {center_dot}}in the nonrotating limit and the critical rotation frequency {approx}1 kHz.

  6. Trials and projects on cervical cancer and human papillomavirus prevention in sub-Saharan Africa.

    PubMed

    Adefuye, Peter O; Broutet, Nathalie J; de Sanjosé, Silvia; Denny, Lynette A

    2013-12-29

    Cervical cancer is the leading cause of cancer morbidity and mortality in women in sub-Saharan Africa (SSA), accounting for about 50,000 deaths annually. Until recently, cytology was the gold standard for screening and prevention of cervical cancer. This method of screening has not been successful in SSA due to a lack of human, financial and material resources and poor health care infrastructure. It is estimated that less than 5% of at risk women have ever being screened. In the past two decades alternative approaches to cytology for cervical cancer screening have been evaluated in low- and medium-income countries. Visual inspection with acetic acid (VIA) and/or Lugol's iodine (VILI) have been shown to have adequate sensitivity, although low specificity, in a number of cross-sectional research and demonstration projects. Visual inspection methods require minimal resources, are technologically accessible, and are feasible for screening for precancerous lesions. Linking screening with VIA/VILI to treatment with cryotherapy may enable screening and treatment to take place in one visit, but this is likely to result in large numbers of women being subjected to unnecessary treatment. A number of studies have shown that cryotherapy is not associated with significant side effects or complications and is well tolerated. Creating the infrastructure for screening of older women is considered desirable, despite the limitations of visual inspection methods as screening tests. Understanding the role of human papillomavirus (HPV) infection in the etiology of cervical cancer and the discovery of HPV rapid test kits, as well as the development of vaccines against the HPV oncogenic types, have created new opportunities for prevention of cervical cancer. Trials and projects have established (and are still ongoing) the feasibility of using these molecular tests for screening. The ultimate in prevention method is primary prevention, offered by the advent of prophylactic vaccines

  7. Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats

    PubMed Central

    Loring, Stephen H.; Pecchiari, Matteo; Valle, Patrizia Della; Monaco, Ario; Gentile, Guendalina; D'Angelo, Edgardo

    2014-01-01

    Objective To see whether in acute lung injury (ALI) 1) compression of the lungs caused by thoracoabdominal constriction degrades lung function and worsens ventilator-induced lung injury (VILI), and 2) maintaining end-expiratory transpulmonary pressure (Pl) by increasing positive end-expiratory pressure (PEEP) reduces the deleterious effects of chest wall constriction. Design Experimental study in rats. Setting Physiology laboratory. Interventions ALI was induced in 3 groups of 9 rats by saline lavage. Nine animals immediately sacrificed served as control group. Group L had lavage only, group LC had the chest wall constricted with an elastic binder, and group LCP had the same chest constriction but with PEEP raised to maintain end-expiratory Pl. After lavage, all groups were ventilated with the same pattern for 1½ hr. Measurements and Main Results Pl, measured with an esophageal balloon-catheter, lung volume changes, arterial blood gasses and pH were assessed during mechanical ventilation (MV). Lung wet-to-dry ratio (W/D), albumin, TNF-α, IL-1β, IL-6, IL-10, and MIP-2 in serum and bronchoalveolar lavage fluid (BALF), and serum E-selectin and von Willebrand Factor (vWF) were measured at the end of MV. Lavage caused hypoxemia and acidemia, increased lung resistance and elastance, and decreased end-expiratory lung volume. With prolonged MV, lung mechanics, hypoxemia, and W/D were significantly worse in group LC. Pro-inflammatory cytokines except E-selectin were elevated in serum and BALF in all groups, with significantly greater levels of TNF-α, IL-1β, and IL-6 in group LC, which also exhibited significantly worse bronchiolar injury and greater heterogeneity of airspace expansion at a fixed Pl than other groups. Conclusions Chest wall constriction in ALI reduces lung volume, worsens hypoxemia, and increases pulmonary edema, mechanical abnormalities, pro-inflammatory mediator release, and histological signs of VILI. Maintaining end-expiratory Pl at preconstriction

  8. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

    PubMed Central

    2011-01-01

    Background A new lower-cost rapid-throughput human papillomavirus (HPV) test (careHPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. Methods We assessed the outcomes and cost-effectiveness of careHPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; careHPV@1.0 pg/ml and careHPV@0.5 pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for careHPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for careHPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using careHPV@1.0) per LYS. Conclusions This modelled analysis suggests that primary careHPV screening compares

  9. [What Should We Know about Respiratory Physiology for the Optimal Anesthesia Management?].

    PubMed

    Ochiai, Ryoichi

    2016-05-01

    Gas exchange in the lungs is dependent on the balance between ventilation and pulmonary perfusion, and such balance could be modified and affected by various factors, including gravity, body position, physical property of the lung, and neurological as well as humoral factors. Oxygenation is the process where the oxygen molecule moves from alveoli to the blood plasma, and this process is highly dependent on the diffusion capacity. Although the oxygen partial pressure in the blood plasma at alveoli rises rapidly because of its very low solubility, hemoglobin is essential to maintain adequate oxygen content in the whole blood. When a part of the lung has atelectasis, pulmonary shunt and desaturation of arterial blood ensue. For the optimal patient care, atelectasis and pulmonary shunt should be taken care of well with thorough monitoring. Ventilation is the process where carbon dioxide (CO2) moves from blood plasma to alveoli, and can eliminate CO2, produced by metabolism. The understanding of ventilator-induced lung injury (VILI) during acute respiratory failure leads us to ventilate the lungs in less harmful way, with lung protective ventilation, and the most important factor is driving pressure (inspiratory plateau pressure-PEEP). When the ventilator setting should be adjusted in order to maintain adequate ventilation, the respiratory frequency is essential to adjust alveolar ventilation without affecting driving pressure. PMID:27319088

  10. Optical coherence tomography and confocal fluorescence microscopy as a combined method for studying morphological changes in lung dynamics

    NASA Astrophysics Data System (ADS)

    Gaertner, Maria; Cimalla, Peter; Knels, Lilla; Meissner, Sven; Schnabel, Christian; Kuebler, Wolfgang M.; Koch, Edmund

    2011-03-01

    Acute lung injury (ALI) is a severe pulmonary disease leading to hypoxemia accompanied by a reduced compliance and partial edema of the lung. Most of the patients have to be ventilated to compensate for the lack of oxygen. The treatment is strongly connected with ventilator induced lung injury (VILI), which is believed to introduce further stress to the lung and changes in its elastic performance. A thorough understanding of the organs micro-structure is crucial to gain more insight into the course of the disease. Due to backscattering of near-infrared light, detailed description of lung morphology can be obtained using optical coherence tomography (OCT), a non-invasive, non-contact, high resolution and fast three-dimensional imaging technique. One of its drawbacks lies in the non-specificity of light distribution in relation to defined substances, like elastic biomolecules. Using fluorescence detection, these chemical components can be visualized by introducing specifically binding fluorophores. This study presents a combined setup for studying alveolar compliance depending on volume changes and elastic fiber distributions. Simultaneously acquired OCT and confocal fluorescence images allow an entire view into morphological rearrangements during ventilation for an ex vivo mouse model using continuous pulmonary airway pressure at different values.

  11. Force control of endothelium permeability in mechanically stressed pulmonary micro-vascular endothelial cells.

    PubMed

    Wang, Bin; Caluch, Adam; Fodil, Redouane; Féréol, Sophie; Zadigue, Patricia; Pelle, Gabriel; Louis, Bruno; Isabey, Daniel

    2012-01-01

    Mechanical factors play a key role in the pathogenesis of Acute Respiratory Distress Syndrome (ARDS) and Ventilator-Induced Lung Injury (VILI) as contributing to alveolo-capillary barrier dysfunction. This study aims at elucidating the role of the cytoskeleton (CSK) and cell-matrix adhesion system in the stressed endothelium and more precisely in the loss of integrity of the endothelial barrier. We purposely develop a cellular model made of a monolayer of confluent Human Pulmonary Microvascular Endothelial Cells (HPMVECs) whose cytoskeleton (CSK) is directly exposed to sustained cyclic mechanical stress for 1 and 2 h. We used RGD-coated ferromagnetic beads and measured permeability before and after stress application. We find that endothelial permeability increases in the stressed endothelium, hence reflecting a loss of integrity. Structural and mechanical results suggest that this endothelial barrier alteration would be due to physically-founded discrepancies in latero-basal reinforcement of adhesion sites in response to the global increase in CSK stiffness or centripetal intracellular forces. Basal reinforcement of adhesion is presently evidenced by the marked redistribution of αvβ3 integrin with cluster formation in the stressed endothelium. PMID:22766716

  12. Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury

    PubMed Central

    Scheiermann, Julia

    2016-01-01

    Background Mechanical ventilation (MV) is commonly used to improve blood oxygenation in critically ill patients and for general anesthesia. Yet the cyclic mechanical stress induced at even moderate ventilation volume settings [tidal volume (Vt) <10 mL/kg] can injure the lungs and induce an inflammatory response. This work explores the effect of treatment with suppressive oligonucleotides (Sup ODN) in a mouse model of ventilator-induced lung injury (VILI). Methods Balb/cJ mice were mechanically ventilated for 4 h using clinically relevant Vt and a positive end-expiratory pressure of 3 cmH2O under 2–3% isoflurane anesthesia. Lung tissue and bronchoalveolar lavage fluid were collected to assess lung inflammation and lung function was monitored using a FlexiVent®. Results MV induced significant pulmonary inflammation characterized by the influx and activation of CD11c+/F4/80+ macrophages and CD11b+/Ly6G+ polymorphonuclear cells into the lung and bronchoalveolar lavage fluid. The concurrent administration of Sup ODN attenuated pulmonary inflammation as evidenced by reduced cellular influx and production of inflammatory cytokines. Oligonucleotide treatment did not worsen lung function as measured by static compliance or resistance. Conclusions Treatment with Sup ODN reduces the lung injury induced by MV in mice. PMID:27746995

  13. [Home mechanical ventilation-tracheostomy ventilation, for the long-term and variation].

    PubMed

    Yamamoto, Makoto

    2006-12-01

    We experienced long-term ventilation for 30 patients mostly with amyotrophic lateral sclerosis (ALS). For long-term ventilation by tracheostomy positive pressure ventilation (TPPV), we must set tidal volume (TV) over 600 ml, because setting 400 ml as TV usually applied in Japan, often develops atelectasis which causes frequent or serious pneumonia. To avoid both the elevation of airway pressure and hyper ventilation, the following intervals are needed: 10 times/min for breathing frequency and 2 seconds for exhaling time. In the cases with ventilator induced lung injury (VILI), it is necessary to lower the TV and to treat with steroid pulse therapy. In the transitional stage from non-invasive positive pressure ventilation (NPPV) to TPPV, we conduct tracheostomy for suction of the sputum. In that stage, by using a cuffless tracheal canule, we can continue NPPV. As another method in that stage, we recommend biphasic management by NPPV at daytime and TPPV at nighttime with a bi-level ventilator. This method can provide certain ventilation also during sleep. When the respiratory failure proceeds further, we manage the ventilation with a bi-level ventilator on TPPV, because a bi-level ventilator is also good adapting to assist spontaneous breathing in that stage. And if the patient does not have bulbar paralysis, the patient can utter by air leakage with using bi-level ventilator and flattening the cuff of the tracheal canule. PMID:17469348

  14. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography

    PubMed Central

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion. PMID:27253433

  15. Syntheses of novel protein products (milkglyde, saliglyde, and soyglyde) from vegetable epoxy oils and gliadin.

    PubMed

    Harry-O'kuru, Rogers E; Mohamed, Abdellatif; Gordon, Sherald H; Xu, James

    2012-02-22

    The aqueous alcohol-soluble fraction of wheat gluten is gliadin. This component has been implicated as the causative principle in celiac disease, which is a physiological condition experienced by some infants and adults. The outcome of the ingestion of whole wheat products by susceptible individuals is malabsorption of nutrients resulting from loss of intestinal vili, the nutrient absorption regions of the digestive system. This leads to incessant diarrhea and weight loss in these individuals. Only recently has this health condition been properly recognized and accurately diagnosed in this country. The culprit gliadin is characterized by preponderant glutamine side-chain residues on the protein surface. Gliadin is commercially available as a wheat gluten extract, and in our search for new biobased and environmentally friendly products from renewable agricultural substrates, we have exploited the availability of the glutamine residues of gliadin as synthons to produce novel elastomeric nonfood products dubbed "milkglyde", "saliglyde", and soyglyde from milkweed, salicornia and soybean oils. The reaction is an amidolysis of the oxirane groups of derivatized milkweed, salicornia, and soybean oils under neat reaction conditions with the primary amide functionalties of glutamine to give the corresponding amidohyroxy gliadinyl triglycerides, respectively. The differential scanning calorimetry, thermogravimetric analyses, and rheological data from a study of these products indicate properties similar to those of synthetic rubber. PMID:22250811

  16. Cervical cancer screening and treatment of cervical intraepithelial neoplasia in female sex workers using “screen and treat” approach

    PubMed Central

    Joshi, Smita; Kulkarni, Vinay; Darak, Trupti; Mahajan, Uma; Srivastava, Yogesh; Gupta, Sanjay; Krishnan, Sumitra; Mandolkar, Mahesh; Bharti, Alok Chandra

    2015-01-01

    Objective Female sex workers (FSWs) are at an increased risk of human immunodeficiency virus (HIV) as well as human papillomavirus (HPV) infections and thus have an increased risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. We evaluated the feasibility of “screen and treat approach” for cervical cancer prevention and the performance of different screening tests among FSWs. Methods Women were screened using cytology, VIA (visual inspection with acetic acid), and VILI (visual inspection with Lugol’s iodine) and underwent colposcopy, biopsy, and immediate treatment using cold coagulation, if indicated, at the same visit. Results We screened 300 FSWs of whom 200 (66.67%) were HIV uninfected and 100 (33.34%) were HIV infected. The overall prevalence of CIN 2–3 lesions was 4.7%. But all women with CIN 2–3 lesions were HIV infected, and thus the prevalence of CIN 2–3 lesions in HIV-infected FSWs was 14/100 (14%, 95% confidence interval: 7.2–20.8). All of them screened positive by all three screening tests. Cold coagulation was well tolerated, with no appreciable side effects. Conclusion Cervical cancer prevention by “screen and treat” approach using VIA, followed by ablative treatment, in this high-risk group of women is feasible and can be implemented through various targeted intervention programs. PMID:25999765

  17. Transpulmonary pressure monitoring during mechanical ventilation: a bench-to-bedside review.

    PubMed

    Mietto, Cristina; Malbrain, Manu L N G; Chiumello, Davide

    2015-01-01

    Different ventilation strategies have been suggested in the past in patients with acute respiratory distress syndrome (ARDS). Airway pressure monitoring alone is inadequate to assure optimal ventilatory support in ARDS patients. The assessment of transpulmonary pressure (PTP) can help clinicians to tailor mechanical ventilation to the individual patient needs. Transpulmonary pressure monitoring, defined as airway pressure (Paw) minus intrathoracic pressure (ITP), provides essential information about chest wall mechanics and its effects on the respiratory system and lung mechanics. The positioning of an esophageal catheter is required to measure the esophageal pressure (Peso), which is clinically used as a surrogate for ITP or pleural pressure (Ppl), and calculates the transpulmonary pressure. The benefits of such a ventilation approach are avoiding excessive lung stress and individualizing the positive end-expiratory pressure (PEEP) setting. The aim is to prevent over-distention of alveoli and the cyclic recruitment/derecruitment or shear stress of lung parenchyma, mechanisms associated with ventilator-induced lung injury (VILI). Knowledge of the real lung distending pressure, i.e. the transpulmonary pressure, has shown to be useful in both controlled and assisted mechanical ventilation. In the latter ventilator modes, Peso measurement allows one to assess a patient's respiratory effort, patient-ventilator asynchrony, intrinsic PEEP and the calculation of work of breathing. Conditions that have an impact on Peso, such as abdominal hypertension, will also be discussed briefly.

  18. Transpulmonary pressure monitoring during mechanical ventilation: a bench-to-bedside review.

    PubMed

    Mietto, Cristina; Malbrain, Manu L N G; Chiumello, Davide

    2015-01-01

    Different ventilation strategies have been suggested in the past in patients with acute respiratory distress syndrome (ARDS). Airway pressure monitoring alone is inadequate to assure optimal ventilatory support in ARDS patients. The assessment of transpulmonary pressure (PTP) can help clinicians to tailor mechanical ventilation to the individual patient needs. Transpulmonary pressure monitoring, defined as airway pressure (Paw) minus intrathoracic pressure (ITP), provides essential information about chest wall mechanics and its effects on the respiratory system and lung mechanics. The positioning of an esophageal catheter is required to measure the esophageal pressure (Peso), which is clinically used as a surrogate for ITP or pleural pressure (Ppl), and calculates the transpulmonary pressure. The benefits of such a ventilation approach are avoiding excessive lung stress and individualizing the positive end-expiratory pressure (PEEP) setting. The aim is to prevent over-distention of alveoli and the cyclic recruitment/derecruitment or shear stress of lung parenchyma, mechanisms associated with ventilator-induced lung injury (VILI). Knowledge of the real lung distending pressure, i.e. the transpulmonary pressure, has shown to be useful in both controlled and assisted mechanical ventilation. In the latter ventilator modes, Peso measurement allows one to assess a patient's respiratory effort, patient-ventilator asynchrony, intrinsic PEEP and the calculation of work of breathing. Conditions that have an impact on Peso, such as abdominal hypertension, will also be discussed briefly. PMID:26575165

  19. Hadronic molecules with a D ¯ meson in a medium

    NASA Astrophysics Data System (ADS)

    Caramés, T. F.; Fontoura, C. E.; Krein, G.; Tsushima, K.; Vijande, J.; Valcarce, A.

    2016-08-01

    We study the effect of a hot and dense medium on the binding energy of hadronic molecules with open-charm mesons. We focus on a recent chiral quark-model-based prediction of a molecular state in the N D ¯ system. We analyze how the two-body thresholds and the hadron-hadron interactions are modified when quark and meson masses and quark-meson couplings change in a function of the temperature and baryon density according to predictions of the Nambu-Jona-Lasinio model. We find that in some cases the molecular binding is enhanced in medium as compared to their free-space binding. We discuss the consequences of our findings for the search for exotic hadrons in high-energy heavy-ion collisions as well as in the forthcoming facilities FAIR or J-PARC.

  20. Quark mass functions and pion structure in Minkowski space

    SciTech Connect

    Biernat, Elmer P.; Gross, Franz L.; Pena, Maria Teresa; Stadler, Alfred

    2014-03-01

    We present a study of the dressed quark mass function and the pion structure in Minkowski space using the Covariant Spectator Theory (CST). The quark propagators are dressed with the same kernel that describes the interaction between different quarks. We use an interaction kernel in momentum space that is a relativistic generalization of the linear confining q-qbar potential and a constant potential shift that defines the energy scale. The confining interaction has a Lorentz scalar part that is not chirally invariant by itself but decouples from the equations in the chiral limit and therefore allows the Nambu--Jona-Lasinio (NJL) mechanism to work. We adjust the parameters of our quark mass function calculated in Minkowski-space to agree with LQCD data obtained in Euclidean space. Results of a calculation of the pion electromagnetic form factor in the relativistic impulse approximation using the same mass function are presented and compared with experimental data.

  1. Quark-gluon thermodynamics with the Bbb Z3 symmetry

    NASA Astrophysics Data System (ADS)

    Sakai, Yuji; Kouno, Hiroaki; Sasaki, Takahiro; Makiyama, Takahiro; Yahiro, Masanobu

    2013-04-01

    We propose a simple model with the Bbb Z3 symmetry in order to answer whether the symmetry is a good concept in QCD with light quark mass. The model is constructed by imposing the flavor-dependent twisted boundary condition (TBC) on the three-flavor Polyakov-loop extended Nambu-Jona-Lasinio model. In the model, the Bbb Z3 symmetry is preserved below some temperature Tc, but spontaneously broken above Tc. Dynamics of the simple model is similar to that of the original PNJL model without the TBC, indicating that the Bbb Z3 symmetry is a good concept. We also investigate the interplay between the Bbb Z3 symmetry and the emergence of the quarkyonic phase.

  2. Quark core of protoneutron stars in the phase diagram of quark matter

    SciTech Connect

    Sandin, F.; Blaschke, D.

    2007-06-15

    We study the effect of neutrino trapping in newborn quark stars within a three-flavor Nambu-Jona-Lasinio model with self-consistently calculated quark masses. The phase diagrams and equations of state for charge neutral quark matter in {beta} equilibrium are presented, with and without trapped neutrinos. The compact star sequences for different neutrino untrapping scenarios are investigated and the energy release due to neutrino untrapping is found to be of the order of 10{sup 53} erg. We find that hot quark stars characterized, e.g., by an entropy per baryon of 1-2 and a lepton fraction of 0.4, as models for the cores of newborn protoneutron stars, are in the two-flavor color superconducting state. High temperatures and/or neutrino chemical potentials disfavor configurations with a color-flavor-locked phase. Stable quark star solutions with color-flavor-locked cores exist only at low temperatures and neutrino chemical potentials.

  3. Generalized parton distributions of the pion in chiral quark models and their QCD evolution

    SciTech Connect

    Broniowski, Wojciech; Ruiz Arriola, Enrique; Golec-Biernat, Krzysztof

    2008-02-01

    We evaluate generalized parton distributions of the pion in two chiral quark models: the spectral quark model and the Nambu-Jona-Lasinio model with a Pauli-Villars regularization. We proceed by the evaluation of double distributions through the use of a manifestly covariant calculation based on the {alpha} representation of propagators. As a result polynomiality is incorporated automatically and calculations become simple. In addition, positivity and normalization constraints, sum rules, and soft-pion theorems are fulfilled. We obtain explicit formulas, holding at the low-energy quark-model scale. The expressions exhibit no factorization in the t-dependence. The QCD evolution of those parton distributions is carried out to experimentally or lattice accessible scales. We argue for the need of evolution by comparing the parton distribution function and the parton distribution amplitude of the pion to the available experimental and lattice data, and confirm that the quark-model scale is low, about 320 MeV.

  4. Properties of magnetized neutral mesons within a full RPA evaluation

    NASA Astrophysics Data System (ADS)

    Avancini, Sidney S.; Tavares, William R.; Pinto, Marcus B.

    2016-01-01

    We consider the two-flavor Nambu-Jona-Lasinio model within the random phase approximation (RPA) framework to evaluate the masses of the σ and π0 mesons and the π0 decay constant in the presence of a magnetic field at vanishing temperatures and baryonic densities. The present work extends other RPA applications by fully considering the external momenta which enter the integrals representing the magnetized polarization tensor. We employ a a field-independent regularization scheme so that more accurate results can be obtained in the evaluation of physical quantities containing pionic contributions. As we show, this technical improvement generates results which agree well with those produced by lattice simulations and chiral perturbation theory. Our method may also prove to be useful in future evaluations of quantities, such as the shear viscosity and the equation of state of magnetized quark matter with mesonic contributions.

  5. The NJL Model for Quark Fragmentation Functions

    SciTech Connect

    T. Ito, W. Bentz, I. Cloet, A W Thomas, K. Yazaki

    2009-10-01

    A description of fragmentation functions which satisfy the momentum and isospin sum rules is presented in an effective quark theory. Concentrating on the pion fragmentation function, we first explain the reason why the elementary (lowest order) fragmentation process q → qπ is completely inadequate to describe the empirical data, although the “crossed” process π → qq describes the quark distribution functions in the pion reasonably well. Then, taking into account cascade-like processes in a modified jet-model approach, we show that the momentum and isospin sum rules can be satisfied naturally without introducing any ad-hoc parameters. We present numerical results for the Nambu-Jona-Lasinio model in the invariant mass regularization scheme, and compare the results with the empirical parametrizations. We argue that this NJL-jet model provides a very useful framework to calculate the fragmentation functions in an effective chiral quark theory.

  6. Multi scale simulation of transport in an open quantum system: Resonances and WKB interpolation

    SciTech Connect

    Abdallah, Naoufel Ben . E-mail: naoufel@mip.ups-tlse.fr; Pinaud, Olivier . E-mail: pinaud@mip.ups-tlse.fr

    2006-03-20

    A numerical scheme for the one-dimensional stationary Schroedinger-Poisson model is described. The scheme is used to simulate a resonant tunneling diode and provides an important reduction of the simulation time. The improvement is twofold. First the grid spacing in the position variable is made coarser by using oscillating interpolation functions derived from the WKB asymptotics. Then the discretization of the energy variable, which is a parameter for the Schroedinger equation, is improved by approaching the wavefunctions in the double barrier region by its projection on the resonant states (following the work of Presilla-Sjoestrand and Jona-Lasinio [On Schroedinger equations with concentrated non-linearities, Ann. Phys. 240 (1995) 1-21])

  7. Critical behaviors near the (tri-)critical end point of QCD within the NJL model

    NASA Astrophysics Data System (ADS)

    Lu, Ya; Du, Yi-Lun; Cui, Zhu-Fang; Zong, Hong-Shi

    2015-10-01

    We investigate the dynamical chiral symmetry breaking and its restoration at finite density and temperature within the two-flavor Nambu-Jona-Lasinio model, and mainly focus on the critical behaviors near the critical end point (CEP) and tricritical point (TCP) of quantum chromodynamics. The multi-solution region of the Nambu and Wigner ones is determined in the phase diagram for the massive and massless current quark, respectively. We use the various susceptibilities to locate the CEP/TCP and then extract the critical exponents near them. Our calculations reveal that the various susceptibilities share the same critical behaviors for the physical current quark mass, while they show different features in the chiral limit.

  8. Comparison of models of critical opacity in the quark-gluon plasma

    SciTech Connect

    Li Xiangdong; Shakin, C.M.

    2004-12-01

    In this work we discuss two methods of calculation of quark propagation in the quark-gluon plasma. Both methods make use of the Nambu-Jona-Lasinio model. The essential difference of these calculations is the treatment of deconfinement. A model of confinement is not included in the work of Gastineau, Blanquier, and Aichelin (e-print hep-ph/0404207), however, the meson states they consider are still bound for temperatures greater than the deconfinement temperature T{sub c}. On the other hand, our model deals with unconfined quarks and includes a description of the qq resonances found in lattice QCD studies that make use of the maximum entropy method. We compare the qq cross sections calculated in these models.

  9. Phase space and quark mass effects in neutrino emissions in a color superconductor

    NASA Astrophysics Data System (ADS)

    Wang, Qun; Wang, Zhi-Gang; Wu, Jian

    2006-07-01

    We study the phase space for neutrino emissions with massive quarks in direct Urca processes in normal and color-superconducting quark matter. We derive in QCD and the Nambu-Jona-Lasinio model the Fermi momentum reduction resulting from Fermi liquid properties which opens up the phase space for neutrino emissions. The relation between the Fermi momentum and chemical potential is found to be pF≈μ(1-κ) with κ depending on coupling constants. We find in the weak coupling regime that κ is a monotonically increasing function of the chemical potential. This implies quenched phase space for neutrino emissions at low baryon densities. We calculate neutrino emissivities with massive quarks in a spin-one color superconductor. The quark mass corrections are found to be of the same order as the contributions in the massless case, which will bring sizable effects on the cooling behavior of compact stars.

  10. Thermodynamics of quark matter with a chiral imbalance

    NASA Astrophysics Data System (ADS)

    Farias, Ricardo L. S.; Duarte, Dyana C.; Krein, Gastão; Ramos, Rudnei O.

    2016-10-01

    We show how a scheme of rewriting a divergent momentum integral can conciliate results obtained with the Nambu-Jona-Lasinio model and recent lattice results for the chiral transition in the presence of a chiral imbalance in quark matter. Purely vacuum contributions are separated from medium-dependent regularized momentum integrals in such a way that one is left with ultraviolet divergent momentum integrals that depend on vacuum quantities only. The scheme is applicable to other commonly used effective models to study quark matter with a chiral imbalance, it allows us to identify the source of their difficulties in reproducing the qualitative features of lattice results, and enhances their predictability and uses in other applications.

  11. The impact of cognitive strategy instruction on deaf learners: an international comparative study.

    PubMed

    Martin, D S; Craft, A; Sheng, Z N

    2001-10-01

    Teacher cohorts in England and China received special training in techniques for teaching higher-level critical and creative cognitive strategies to deaf learners. Both cohorts implemented the strategies in the classroom at least twice weekly for 6 months. Measures included Raven's Standard Progressive Matrices (1959), a systematic observation checklist for cognitive behaviors (Martin & Craft, 1998), and critical and creative problem situations to which students had to respond. Results were compared with those from a study of similar learners in the United States (Martin & Jonas, 1985), and little difference was found. Students in all three countries improved in reasoning, devising real-world problem solutions involving critical thinking (but not creative thinking), using cognitive vocabulary in the classroom, and expressing others' viewpoints. Postintervention focus groups showed teachers in China used a more invariant sequence in teaching the cognitive strategies, but teachers in all three countries experienced similar expansion in cognitive terminology and self-perceptions as teachers of problem solving.

  12. Ideal quarks and mesons in the relativistic quark model

    SciTech Connect

    Kaneko, K. )

    1994-05-01

    We propose a microscopic theory for interacting mesons and ideal quarks in the relativistic quark model using the time-dependent mean-field theory technique. For simplicity we examined the Nambu--Jona-Lasinio model. The dynamical chiral-symmetry breaking leads to a zero-frequency mode (pion) due to the restoration of chiral symmetry. The ideal quarks are represented as dressed particles independent of mean fields, and do not have the conventional properties of fermions. This is due to the constraints of eliminating the double counting of degrees of freedom between the mean fields and quarks. The small fluctuation around the static solution is then investigated. The pseudoscalar and scalar mesons are represented as the collective modes of the mean fields.

  13. Probing the QCD vacuum with an Abelian chromomagnetic field: A study within an effective model

    SciTech Connect

    Campanelli, L.; Ruggieri, M.

    2009-08-01

    We study the response of the QCD vacuum to an external Abelian chromomagnetic field in the framework of a nonlocal Nambu-Jona-Lasinio model with the Polyakov loop. We use the lattice results on the deconfinement temperature of the pure gauge theory to compute the same quantity in the presence of dynamical quarks. We find a linear relationship between the deconfinement temperature with quarks and the squared root of the applied field strength, gH, in qualitative (and to some extent also quantitative) agreement with existing lattice calculations. On the other hand, we find a discrepancy on the approximate chiral symmetry restoration: while lattice results suggest the deconfinement and the chiral restoration remain linked even at a nonzero value of gH, our results are consistent with a scenario in which the two transitions are separated as gH is increased.

  14. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    NASA Astrophysics Data System (ADS)

    Azaria, P.; Konik, R. M.; Lecheminant, P.; Pálmai, T.; Takács, G.; Tsvelik, A. M.

    2016-08-01

    In this paper we study a (1 +1 )-dimensional version of the famous Nambu-Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ , is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ =0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phases with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). The QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).

  15. Betti numbers of graded modules and cohomology of vector bundles

    NASA Astrophysics Data System (ADS)

    Eisenbud, David; Schreyer, Frank-Olaf

    2009-07-01

    In the remarkable paper Graded Betti numbers of Cohen-Macaulay modules and the multiplicity conjecture, Mats Boij and Jonas Soederberg conjectured that the Betti table of a Cohen-Macaulay module over a polynomial ring is a positive linear combination of Betti tables of modules with pure resolutions. We prove a strengthened form of their conjectures. Applications include a proof of the Multiplicity Conjecture of Huneke and Srinivasan and a proof of the convexity of a fan naturally associated to the Young lattice. With the same tools we show that the cohomology table of any vector bundle on projective space is a positive rational linear combination of the cohomology tables of what we call supernatural vector bundles. Using this result we give new bounds on the slope of a vector bundle in terms of its cohomology.

  16. Standard model bosons as composite particles

    SciTech Connect

    Kahana, D.E. . Continuous Electron Beam Accelerator Facility); Kahana, S.H. )

    1990-01-01

    The Standard model of electro-weak interactions is derived from a Nambu, Jona-Lasinio type four-fermion interaction, which is assumed to result from a more basic theory valid above a very high scale {Lambda}. The masses of the gauge bosons and the Higgs are then produced by dynamical symmetry breaking of the Nambu model at an intermediate scale {mu}, and are evolved back to experimental energies via the renormalisation group equations of the Standard model. The weak angle sin{sup 2} ({theta}{sub W}) is predicted to be 3/8 at the scale {mu}, as in grand unified theories, and is evolved back to the experimental value at scale M{sub W}, thus determining {mu} {approximately}10{sup 13}GeV. Predictions for the ratios of the masses of the gauge and the Higgs bosons to the top quark mass, at experimental energies, are also obtained.

  17. Ab initio calculation of a global potential, vibrational energies, and wave functions for HCN/HNC, and a simulation of the (A-tilde)-(X-tilde) emission spectrum

    NASA Technical Reports Server (NTRS)

    Bowman, Joel M.; Gazdy, Bela; Bentley, Joseph A.; Lee, Timothy J.; Dateo, Christopher E.

    1993-01-01

    A potential energy surface for the HCN/HNC system which is a fit to extensive, high-quality ab initio, coupled-cluster calculations is presented. All HCN and HNC states with energies below the energy of the first delocalized state are reported and characterized. Vibrational transition energies are compared with all available experimental data on HCN and HNC, including high CH-overtone states up to 23,063/cm. A simulation of the (A-tilde)-(X-tilde) stimulated emission pumping (SEP) spectrum is also reported, and the results are compared to experiment. Franck-Condon factors are reported for odd bending states of HCN, with one quantum of vibrational angular momentum, in order to compare with the recent assignment by Jonas et al. (1992), on the basis of axis-switching arguments of a number of previously unassigned states in the SEP spectrum.

  18. Nonmagnetic impurity effects of the spin disordered state in NiGa2S4

    NASA Astrophysics Data System (ADS)

    Nambu, Yusuke; Nakatsuji, Satoru; Maeno, Yoshiteru

    2006-03-01

    Nonmagnetic impurity effects of the spin disordered state in the triangular antiferromagnet NiGa2S4[1] was studied through magnetic and thermal measurements for Zn substituted insulating materials Ni1-xZnxGa2S4 (0.0 <= x <= 0.3)[2]. Only 1 % Zn substitution is enough to strongly suppress the coherence observed in the spin disordered state. However, suppression is not complete and the robust feature of the quadratic temperature dependent specific heat and its scaling behavior with the Weiss temperature indicate the existence of a coherent Nambu-Goldstone mode. Absence of either conventional magnetic long-range order or bulk spin freezing suggests a novel symmetry breaking of the ground state. [1] Satoru Nakatsuji, Yusuke Nambu, Hiroshi Tonomura, Osamu Sakai, Seth Jonas, Collin Broholm, Hirokazu Tsunetsugu, Yiming Qiu and Yoshiteru Maeno, Science 309, 1697 (2005). [2] Yusuke Nambu, Satoru Nakatsuji and Yoshiteru Maeno, preprint.

  19. QCD Phase Diagram at Finite Baryon and Isospin Chemical Potentials

    SciTech Connect

    Sasaki, T.; Sakai, Y.; Yahiro, M.; Kouno, H.

    2011-10-21

    The phase structure of two-flavor QCD is explored for finite temperature T and finite baryon- and isospin-chemical potentials, {mu}{sub B} and {mu}{sub I}, by using the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. The PNJL model with the scalar-type eight-quark interaction can reproduce lattice QCD data in the {mu}{sub I}-T plane at {mu}{sub B} = 0. In the {mu}{sub I}-{mu}{sub B}-T space, the critical endpoint of the chiral phase transition in the {mu}{sub B}-T plane at {mu}{sub I} = 0 moves to the tricritical point of the pion-superfluidity phase transition in the {mu}{sub I}-T plane at {mu}{sub B} = 0 as {mu}{sub I} increases.

  20. Entanglement between deconfinement transition and chiral symmetry restoration

    SciTech Connect

    Sakai, Yuji; Sasaki, Takahiro; Yahiro, Masanobu; Kouno, Hiroaki

    2010-10-01

    We extend the Polyakov-loop extended Nambu-Jona-Lasinio model by introducing an effective four-quark vertex depending on the Polyakov loop. The effective vertex generates entanglement interactions between the Polyakov loop and the chiral condensate. The new model is consistent with lattice QCD data at imaginary quark-number chemical potential and real and imaginary isospin chemical potentials, particularly on the strong correlation between the chiral and deconfinement transitions and also on the quark-mass dependence of the order of the Roberge-Weiss endpoint. We investigate the influence of the entanglement interactions on the location of the tricritical point at real isospin chemical potential and on the location of the critical endpoint at real quark-number chemical potential.

  1. QCD flux tubes and anomaly inflow

    NASA Astrophysics Data System (ADS)

    Xiong, Chi

    2013-07-01

    We apply the Callan-Harvey anomaly-inflow mechanism to the study of QCD (chromoelectric) flux tubes, quark (pair) creation, and the chiral magnetic effect, using new variables from the Cho-Faddeev-Niemi decomposition of the gauge potential. A phenomenological description of chromoelectric flux tubes is obtained by studying a gauged Nambu-Jona-Lasinio effective Lagrangian, derived from the original QCD Lagrangian. At the quantum level, quark condensates in the QCD vacuum may form a vortexlike structure in a chromoelectric flux tube. Quark zero modes trapped in the vortex are chiral and lead to a two-dimensional gauge anomaly. To cancel it, an effective Chern-Simons coupling is needed and, hence, a topological charge density term naturally appears.

  2. Low-energy phenomenology of scalarless standard-model extensions with high-energy Lorentz violation

    SciTech Connect

    Anselmi, Damiano; Ciuffoli, Emilio

    2011-03-01

    We consider renormalizable standard model extensions that violate Lorentz symmetry at high energies, but preserve CPT, and do not contain elementary scalar fields. A Nambu-Jona-Lasinio mechanism gives masses to fermions and gauge bosons and generates composite Higgs fields at low energies. We study the effective potential at the leading order of the large-N{sub c} expansion, prove that there exists a broken phase, and study the phase space. In general, the minimum may break invariance under boosts, rotations, and CPT, but we give evidence that there exists a Lorentz invariant phase. We study the spectrum of composite bosons and the low-energy theory in the Lorentz phase. Our approach predicts relations among the parameters of the low-energy theory. We find that such relations are compatible with the experimental data within theoretical errors. We also study the mixing among generations, the emergence of the CKM matrix, and neutrino oscillations.

  3. Symmetries in Physics

    NASA Astrophysics Data System (ADS)

    Brading, Katherine; Castellani, Elena

    2003-12-01

    Preface; Copyright acknowledgements; List of contributors; 1. Introduction; Part I. Continuous Symmetries: 2. Classic texts: extracts from Weyl and Wigner; 3. Review paper: On the significance of continuous symmetry to the foundations of physics C. Martin; 4. The philosophical roots of the gauge principle: Weyl and transcendental phenomenological idealism T. Ryckman; 5. Symmetries and Noether's theorems K. A. Brading and H. R. Brown; 6. General covariance, gauge theories, and the Kretschmann objection J. Norton; 7. The interpretation of gauge symmetry M. Redhead; 8. Tracking down gauge: an ode to the constrained Hamiltonian formalism J. Earman; 9. Time-dependent symmetries: the link between gauge symmetries and indeterminism D. Wallace; 10. A fourth way to the Aharanov-Bohm effect A. Nounou; Part II. Discrete Symmetries: 11. Classic texts: extracts from Lebniz, Kant and Black; 12. Review paper: Understanding permutation symmetry S. French and D. Rickles; 13. Quarticles and the identity of discernibles N. Hugget; 14. Review paper: Handedness, parity violation, and the reality of space O. Pooley; 15. Mirror symmetry: what is it for a relational space to be orientable? N. Huggett; 16. Physics and Leibniz's principles S. Saunders; Part III. Symmetry Breaking: 17: Classic texts: extracts from Curie and Weyl; 18. Extract from G. Jona-Lasinio: Cross-fertilization in theoretical physics: the case of condensed matter and particle physics G. Jona-Lasinio; 19. Review paper: On the meaning of symmetry breaking E. Castellani; 20. Rough guide to spontaneous symmetry breaking J. Earman; 21. Spontaneous symmetry breaking: theoretical arguments and philosophical problems M. Morrison; Part IV. General Interpretative Issues: 22. Classic texts: extracts from Wigner; 23. Symmetry as a guide to superfluous theoretical structure J. Ismael and B. van Fraassen; 24. Notes on symmetries G. Belot; 25. Symmetry, objectivity, and design P. Kosso; 26. Symmetry and equivalence E. Castellani.

  4. Symmetries in Physics

    NASA Astrophysics Data System (ADS)

    Brading, Katherine; Castellani, Elena

    2010-01-01

    Preface; Copyright acknowledgements; List of contributors; 1. Introduction; Part I. Continuous Symmetries: 2. Classic texts: extracts from Weyl and Wigner; 3. Review paper: On the significance of continuous symmetry to the foundations of physics C. Martin; 4. The philosophical roots of the gauge principle: Weyl and transcendental phenomenological idealism T. Ryckman; 5. Symmetries and Noether's theorems K. A. Brading and H. R. Brown; 6. General covariance, gauge theories, and the Kretschmann objection J. Norton; 7. The interpretation of gauge symmetry M. Redhead; 8. Tracking down gauge: an ode to the constrained Hamiltonian formalism J. Earman; 9. Time-dependent symmetries: the link between gauge symmetries and indeterminism D. Wallace; 10. A fourth way to the Aharanov-Bohm effect A. Nounou; Part II. Discrete Symmetries: 11. Classic texts: extracts from Lebniz, Kant and Black; 12. Review paper: Understanding permutation symmetry S. French and D. Rickles; 13. Quarticles and the identity of discernibles N. Hugget; 14. Review paper: Handedness, parity violation, and the reality of space O. Pooley; 15. Mirror symmetry: what is it for a relational space to be orientable? N. Huggett; 16. Physics and Leibniz's principles S. Saunders; Part III. Symmetry Breaking: 17: Classic texts: extracts from Curie and Weyl; 18. Extract from G. Jona-Lasinio: Cross-fertilization in theoretical physics: the case of condensed matter and particle physics G. Jona-Lasinio; 19. Review paper: On the meaning of symmetry breaking E. Castellani; 20. Rough guide to spontaneous symmetry breaking J. Earman; 21. Spontaneous symmetry breaking: theoretical arguments and philosophical problems M. Morrison; Part IV. General Interpretative Issues: 22. Classic texts: extracts from Wigner; 23. Symmetry as a guide to superfluous theoretical structure J. Ismael and B. van Fraassen; 24. Notes on symmetries G. Belot; 25. Symmetry, objectivity, and design P. Kosso; 26. Symmetry and equivalence E. Castellani.

  5. [Penile implantation surgery for organic impotence due to radical cystectomy or prostatectomy].

    PubMed

    Okada, Y; Kuo, Y J; Hida, S; Nishio, Y; Yoshida, O; Arai, Y; Kihara, Y; Mishina, T

    1987-10-01

    Implantation surgery was performed twelve times in eleven patients with organic impotence, mainly due to radical cystectomy and prostatectomy against malignancy, between March, 1982 and April, 1987. A self-contained type prosthesis (AMS Hydroflex(TM] was used in 7 cases, reservoir type inflatable prosthesis (AMS 700TM) in 2, malleable semirigid type (ESKA-Jonas Silicon Silver(TM) Trimming Tip Version) in 2, and nonmalleable semirigid type (Fuji system Finney type) in 1 case. In the last case, the prosthesis was replaced by AMS Hydroflex 4.5 years later at patient's wish. Excellent results and good patients' acceptance were gained with inflatable-type prosthesis (AMS 700 and Hydroflex) in 7 out of 8 cases (88%), whereas concealment problems were produced by semirigid type prosthesis (Finney and Jonas). Experience with AMS Hydroflex penile implantation is reported for the first time in the Japanese literature. Intraoperatively, it was sometimes difficult to implant a pair of Hydroflex rods into both of the corpus cavernosum. Postoperative perineal pain was almost constantly seen and in one patient, penile edema continued for three weeks and subsided spontaneously in two months. In another patient, the length of the prosthesis (15 cm) was short, and exchange to the longer one (17 cm) was necessary. In this patient, the longer Hydroflex caused erosion of the glans to necessitate its removal on one side. From our experience, the diameter (11 mm) of the Hydroflex seems to be too big for the average Japanese patient. The operative procedures and results of each kind of the prostheses are briefly discussed. PMID:3445849

  6. The responsible subject in the global age.

    PubMed

    Pulcini, Elena

    2010-09-01

    The first thesis of this article is that the concept of responsibility takes on an unprecedented meaning in the twentieth century resulting from the emergence of a new dimension of the other: to be responsible comes to mean not just to account for oneself in relation to the other, but also to take the other into account, to take care of the other-what I call responsibility towards (the other). The main reason for this change consists in the emergence of global risks and the necessity, as underlined by Hans Jonas, to be responsible for the destiny of the world and future generations. The problem, as explored in the article's second thesis, is that this implies the existence of a subject who is capable of responsibility. Jonas's insights on this point are insufficient, since he only recognizes duty as the fundament for his ethics of responsibility and thus neglects the problem of motivation. This is a particularly crucial problem today as we are witnessing the presence of a pathological subject, characterized by a split in his faculties (between doing and imagining, knowing and feeling). To underline this fact, this article makes use of Günther Anders's reflections, which provide a psycho-anthropological analysis of the subject, showing his pathologies and the necessity, from a moral perspective, to overcome his scission. Finally, this author suggests, as the article's third thesis, that this overcoming is the necessary fundament for the perception of risk, which in turn reinstates the subject's perception of his own vulnerability. Responsibility thus finds a motivation, which is neither altruistic nor duty-centred, in the awareness of our own vulnerability and the bond with the destiny of humankind as a whole.

  7. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.

    PubMed

    Mathew, Biji; Takekoshi, Daisuke; Sammani, Saad; Epshtein, Yulia; Sharma, Rajesh; Smith, Brett D; Mitra, Sumegha; Desai, Ankit A; Weichselbaum, Ralph R; Garcia, Joe G N; Jacobson, Jeffrey R

    2015-12-15

    We previously reported protective effects of GADD45a (growth arrest and DNA damage-inducible gene 45 alpha) in murine ventilator-induced lung injury (VILI) via effects on Akt-mediated endothelial cell signaling. In the present study we investigated the role of GADD45a in separate murine models of radiation- and bleomycin-induced lung injury. Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a(-/-)) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a(-/-) mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt(+/-) mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. Additionally, overexpression of a constitutively active Akt1 transgene reversed RILI-susceptibility in GADD45a(-/-) mice. In separate studies, lung fibrotic changes 2 wk after treatment with bleomycin (0.25 U/kg IT) was significantly increased in GADD45a(-/-) mice compared with wild-type mice assessed by lung collagen content and histology. These data implicate GADD45a as an important modulator of lung inflammatory responses across different injury models and highlight GADD45a-mediated signaling as a novel target in inflammatory lung injury clinically.

  8. The influence of Cl, F and Mg ions on the experimental replacement of Carrara marble by apatite

    NASA Astrophysics Data System (ADS)

    Trindade Pedrosa, Elisabete; Putnis, Andrew

    2014-05-01

    Fluid-solid interactions span a very wide range of possible reactions, and are responsible for most of the mineral assemblages in the Earth's crust. Reequilibration processes in a wide range of materials are dominated by dissolution and reprecipitation mechanisms. The interaction of aqueous fluids with these materials results in a remarkable consistency of behaviour, especially in the way that the dissolution and precipitation processes are coupled, and how the relative solubility and molar volume combine to create porosity which allows fluid to continuously migrate to the reaction interface. The recent discovery that the coupling can be manipulated by changing the fluid composition not only emphasizes the role of the fluid in the coupling but opens new avenues for materials syntheses (Putnis, 2009). Recently, a study by Jonas et al., (2013) used as a model the pseudomorphic replacement of Carrara marble (calcite - CaCO3) by calcium phosphates (Ca5P(O4)3(OH, Cl,F) to show that the grain boundaries present in the rock and the transient porosity structures developing throughout the replacement reaction, enabled the reaction front to progress further into the rock, as well as to the center of each single grain until complete transformation. In the present study, the same system was used to explore the rates and evolution of such replacement in the presence of different ions in the fluid used for reaction. Small Carrara marble cubes of around 2 mm3 were treated in hydrothermal reaction vessels at 200°C using phosphate bearing solutions with and without the presence of the different ions: chlorine, fluorine and magnesium. Mounted and polished cross sections of the reacted samples were examined by scanning electron microscopy and electron microprobe analysis to determine the extent of replacement, the textural evolution and the composition of the product phases. Results show that changes in the chemistry of the fluid seem to influence the evolution of the reaction front

  9. Web-based interactive access, analysis and comparison of remotely sensed and in situ measured temperature data

    NASA Astrophysics Data System (ADS)

    Eberle, Jonas; Urban, Marcel; Hüttich, Christian; Schmullius, Christiane

    2014-05-01

    Numerous datasets providing temperature information from meteorological stations or remote sensing satellites are available. However, the challenging issue is to search in the archives and process the time series information for further analysis. These steps can be automated for each individual product, if the pre-conditions are complied, e.g. data access through web services (HTTP, FTP) or legal rights to redistribute the datasets. Therefore a python-based package was developed to provide data access and data processing tools for MODIS Land Surface Temperature (LST) data, which is provided by NASA Land Processed Distributed Active Archive Center (LPDAAC), as well as the Global Surface Summary of the Day (GSOD) and the Global Historical Climatology Network (GHCN) daily datasets provided by NOAA National Climatic Data Center (NCDC). The package to access and process the information is available as web services used by an interactive web portal for simple data access and analysis. Tools for time series analysis were linked to the system, e.g. time series plotting, decomposition, aggregation (monthly, seasonal, etc.), trend analyses, and breakpoint detection. Especially for temperature data a plot was integrated for the comparison of two temperature datasets based on the work by Urban et al. (2013). As a first result, a kernel density plot compares daily MODIS LST from satellites Aqua and Terra with daily means from GSOD and GHCN datasets. Without any data download and data processing, the users can analyze different time series datasets in an easy-to-use web portal. As a first use case, we built up this complimentary system with remotely sensed MODIS data and in situ measurements from meteorological stations for Siberia within the Siberian Earth System Science Cluster (www.sibessc.uni-jena.de). References: Urban, Marcel; Eberle, Jonas; Hüttich, Christian; Schmullius, Christiane; Herold, Martin. 2013. "Comparison of Satellite-Derived Land Surface Temperature and Air

  10. Quark matter symmetry energy and quark stars

    SciTech Connect

    Chu, Peng-Cheng; Chen, Lie-Wen

    2014-01-10

    We extend the confined-density-dependent-mass (CDDM) model to include isospin dependence of the equivalent quark mass. Within the confined-isospin-density-dependent-mass (CIDDM) model, we study the quark matter symmetry energy, the stability of strange quark matter, and the properties of quark stars. We find that including isospin dependence of the equivalent quark mass can significantly influence the quark matter symmetry energy as well as the properties of strange quark matter and quark stars. While the recently discovered large mass pulsars PSR J1614–2230 and PSR J0348+0432 with masses around 2 M {sub ☉} cannot be quark stars within the CDDM model, they can be well described by quark stars in the CIDDM model. In particular, our results indicate that the two-flavor u-d quark matter symmetry energy should be at least about twice that of a free quark gas or normal quark matter within the conventional Nambu-Jona-Lasinio model in order to describe PSR J1614–2230 and PSR J0348+0432 as quark stars.

  11. Influence of pions on the hadron-quark phase transition

    SciTech Connect

    Lourenco, O.; Dutra, M.; Frederico, T.; Malheiro, M.; Delfino, A.

    2013-05-06

    In this work we present the features of the hadron-quark phase transition diagrams in which the pions are included in the system. To construct such diagrams we use two different models in the description of the hadronic and quark sectors. At the quark level, we consider two distinct parametrizations of the Polyakov-Nambu-Jona-Lasinio (PNJL) models. In the hadronic side, we use a well known relativistic mean-field (RMF) nonlinear Walecka model. We show that the effect of the pions on the hadron-quark phase diagrams is to move the critical end point (CEP) of the transitions lines. Such an effect also depends on the value of the critical temperature (T{sub 0}) in the pure gauge sector used to parametrize the PNJL models. Here we treat the phase transitions using two values for T{sub 0}, namely, T{sub 0}= 270 MeV and T{sub 0}= 190 MeV. The last value is used to reproduce lattice QCD data for the transition temperature at zero chemical potential.

  12. Bounds on quantum gravity parameter from the SU(2) NJL effective model of QCD

    NASA Astrophysics Data System (ADS)

    Nozari, K.; Khodadi, M.; Gorji, M. A.

    2015-12-01

    The existence of a minimal measurable length, as an effective cutoff in the ultraviolet regime, is a common feature of all approaches to the quantum gravity proposal. It is widely believed that this length scale will be of the order of the Planck length λ=λ0 l\\text{Pl} , where λ_0∼O(1) is a dimensionless parameter that should be fixed only by the experiments. This issue can be taken into account through the deformed momentum spaces with compact topologies. In this paper, we consider minimum length effects on the physical quantities related to three parameters of the SU(2) Nambu-Jona-Lasinio effective model of QCD by means of the deformed measure which is defined on the compact momentum space with S 3 topology. This measure is suggested by the doubly special relativity theories, Snyder deformed spaces, and the deformed algebra that is obtained in the light of the stability theory of Lie algebras. Using the current experimental data of the particle physics collaboration, we constrain the quantum gravity parameter λ 0 and we compare our results with bounds that are arisen from the other experimental setups.

  13. Generalized quark transversity distribution of the pion in chiral quark models

    SciTech Connect

    Dorokhov, Alexander E.; Broniowski, Wojciech; Arriola, Enrique Ruiz

    2011-10-01

    The transversity generalized parton distributions (tGPDs) of the pion, involving matrix elements of the tensor bilocal quark current, are analyzed in chiral quark models. We apply the nonlocal chiral models involving a momentum-dependent quark mass, as well as the local Nambu-Jona-Lasinio with the Pauli-Villars regularization to calculate the pion tGPDs, as well as related quantities following from restrained kinematics, evaluation of moments, or taking the Fourier-Bessel transforms to the impact-parameter space. The obtained distributions satisfy the formal requirements, such as proper support and polynomiality, following from Lorentz covariance. We carry out the leading-order QCD evolution from the low quark-model scale to higher lattice scales, applying the method of Kivel and Mankiewicz. We evaluate several lowest-order generalized transversity form factors, accessible from the recent lattice QCD calculations. These form factors, after evolution, agree properly with the lattice data, in support of the fact that the spontaneously broken chiral symmetry is the key element also in the evaluation of the transversity observables.

  14. Photon distribution amplitudes and light-cone wave functions in chiral quark models

    SciTech Connect

    Dorokhov, Alexander E.; Broniowski, Wojciech; Ruiz Arriola, Enrique

    2006-09-01

    The leading- and higher-twist distribution amplitudes and light-cone wave functions of real and virtual photons are analyzed in chiral quark models. The calculations are performed in the nonlocal quark model based on the instanton picture of the QCD vacuum, as well as in the spectral quark model and the Nambu-Jona-Lasinio model with the Pauli-Villars regulator, which both treat interaction of quarks with external fields locally. We find that in all considered models the leading-twist distribution amplitudes of the real photon defined at the quark-model momentum scale are constant or remarkably close to the constant in the x variable, thus are far from the asymptotic limit form. The QCD evolution to higher momentum scales is necessary and we carry it out at the leading order of the perturbative theory for the leading-twist amplitudes. We provide estimates for the magnetic susceptibility of the quark condensate {chi}{sub m} and the coupling f{sub 3{gamma}}, which in the nonlocal model turn out to be close to the estimates from QCD sum rules. We find the higher-twist distribution amplitudes at the quark model scale and compare them to the Wandzura-Wilczek estimates. In addition, in the spectral model we evaluate the distribution amplitudes and light-cone wave functions of the {rho}-meson.

  15. Polio and Nobel prizes: looking back 50 years.

    PubMed

    Norrby, Erling; Prusiner, Stanley B

    2007-05-01

    In 1954, John Enders, Thomas Weller, and Frederick Robbins were awarded the Nobel Prize in Physiology or Medicine "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue."5370 This discovery provided for the first time opportunities to produce both inactivated and live polio vaccines. By searching previously sealed Nobel Committee archives, we were able to review the deliberations that led to the award. It appears that Sven Gard, who was Professor of Virus Research at the Karolinska Institute and an adjunct member of the Nobel Committee at the time, played a major role in the events leading to the awarding of the Prize. It appears that Gard persuaded the College of Teachers at the Institute to decide not to follow the recommendation by their Nobel Committee to give the Prize to Vincent du Vigneaud. Another peculiar feature of the 1954 Prize is that Weller and Robbins were included based on only two nominations submitted for the first time that year. In his speech at the Nobel Prize ceremony, Gard mentioned the importance of the discovery for the future production of vaccines, but emphasized the implications of this work for growing many different, medically important viruses. We can only speculate on why later nominations highlighting the contributions of scientists such as Jonas Salk, Hilary Koprowski, and Albert Sabin in the development of poliovirus vaccines have not been recognized by a Nobel Prize. PMID:17469121

  16. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    NASA Astrophysics Data System (ADS)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2016-06-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates ( 10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass ( α ) transition and the secondary ( β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  17. Toward a first-principle derivation of confinement and chiral-symmetry-breaking crossover transitions in QCD

    SciTech Connect

    Kondo, Kei-Ichi

    2010-09-15

    We give a theoretical framework to obtain a low-energy effective theory of quantum chromodynamics (QCD) towards a first-principle derivation of confinement/deconfinement and chiral-symmetry breaking/restoration crossover transitions. In fact, we demonstrate that an effective theory obtained using simple but nontrivial approximations within this framework enables us to treat both transitions simultaneously on equal footing. A resulting effective theory is regarded as a modified and improved version of nonlocal Polyakov-loop extended Nambu-Jona-Lasinio (nonlocal PNJL) models proposed recently by Hell, Roessner, Cristoforetti, and Weise, and Sasaki, Friman, and Redlich, extending the original (local) PNJL model by Fukushima and others. A novel feature is that the nonlocal NJL coupling depends explicitly on the temperature and Polyakov loop, which affects the entanglement between confinement and chiral-symmetry breaking, together with the cross term introduced through the covariant derivative in the quark sector considered in the conventional PNJL model. The chiral-symmetry breaking/restoration transition is controlled by the nonlocal NJL interaction, while the confinement/deconfinement transition in the pure gluon sector is specified by the nonperturbative effective potential for the Polyakov loop obtained recently by Braun, Gies, Marhauser, and Pawlowski. The basic ingredients are a reformulation of QCD based on new variables and the flow equation of the Wetterich type in the Wilsonian renormalization group. This framework can be applied to investigate the QCD phase diagram at finite temperature and density.

  18. Probing the hadron-quark mixed phase at high isospin and baryon density. Sensitive observables

    NASA Astrophysics Data System (ADS)

    Di Toro, Massimo; Colonna, Maria; Greco, Vincenzo; Shao, Guo-Yun

    2016-08-01

    We discuss the isospin effect on the possible phase transition from hadronic to quark matter at high baryon density and finite temperatures. The two-Equation of State (Two-EoS) model is adopted to describe the hadron-quark phase transition in dense matter formed in heavy-ion collisions. For the hadron sector we use Relativistic Mean-Field (RMF) effective models, already tested on heavy-ion collision (HIC). For the quark phase we consider various effective models, the MIT-Bag static picture, the Nambu-Jona-Lasinio (NJL) approach with chiral dynamics and finally the NJL coupled to the Polyakov-loop field (PNJL), which includes both chiral and (de)confinement dynamics. The idea is to extract mixed phase properties which appear robust with respect to the model differences. In particular we focus on the phase transitions of isospin asymmetric matter, with two main results: i) an earlier transition to a mixed hadron-quark phase, at lower baryon density/chemical potential with respect to symmetric matter; ii) an "Isospin Distillation" to the quark component of the mixed phase, with predicted effects on the final hadron production. Possible observation signals are suggested to probe in heavy-ion collision experiments at intermediate energies, in the range of the NICA program.

  19. How can video supported reflection enhance teachers' professional development?

    NASA Astrophysics Data System (ADS)

    McCullagh, John F.

    2012-03-01

    This paper responds to Eva Lundqvist, Jonas Almqvist and Leif Ostman's account of how the manner of teaching can strongly influence pupil learning by recommending video supported reflection as a means by which teachers can transform the nature of their practice. Given the complex nature of the many conditions which influence and control teachers' actions the reframing of routine practice through reflection-in-action can prove challenging. This response paper describes how video can empower teachers to take greater control of their progress and allows for a more social constructivist approach to professional development. Along with a consideration of the difficulties associated with the notion of `reflection' and a short case study, the paper uses Lev Semenovich Vygotsky's zone of proximal development and the notion of scaffolding to propose that video offers a Video Supported Zone of Proximal Development which can ease the process of teacher development. In capturing permanent and exchangeable representations of practice video encourages a collaborative approach to reflection and is consistent with the original ideas of John Dewey.

  20. Isospin properties of quark matter from a 3-flavor NJL model

    NASA Astrophysics Data System (ADS)

    Liu, He; Xu, Jun; Chen, Lie-Wen; Sun, Kai-Jia

    2016-09-01

    We have studied the properties of hot and dense quark matter based on the 3-flavor Nambu-Jona-Lasinio (NJL) model as well as its Polyakov-loop extension (pNJL) with scalar-isovector and vector-isovector couplings. Provided a considerable large isospin asymmetry or isospin chemical potential, isospin splittings of constituent mass, chiral phase transition boundary, and critical point for u and d quarks can be observed for positive isovector coupling constants but are suppressed for negative ones. The quark matter symmetry energy decreases with the increasing isovector coupling constant, and is mostly enhanced in the pNJL model than in the NJL model. A positive scalar-isovector coupling constant is more likely to lead to an unstable isospin asymmetric quark matter. The isovector coupling has been further found to affect particle fractions as well as the equation of state in hybrid stars. Possible effects on the isospin properties of quark matter have also been discussed if the strangeness sector is further broken among the flavor symmetry.

  1. Flavor dependence of the pion and kaon form factors and parton distribution functions

    NASA Astrophysics Data System (ADS)

    Hutauruk, Parada T. P.; Cloët, Ian C.; Thomas, Anthony W.

    2016-09-01

    The separate quark flavor contributions to the pion and kaon valence quark distribution functions are studied, along with the corresponding electromagnetic form factors in the space-like region. The calculations are made using the solution of the Bethe-Salpeter equation for the model of Nambu and Jona-Lasinio with proper-time regularization. Both the pion and kaon form factors and the valence quark distribution functions reproduce many features of the available empirical data. The larger mass of the strange quark naturally explains the empirical fact that the ratio uK+(x ) /uπ+(x ) drops below unity at large x , with a value of approximately Mu2/Ms2 as x →1 . With regard to the elastic form factors we report a large flavor dependence, with the u -quark contribution to the kaon form factor being an order of magnitude smaller than that of the s -quark at large Q2, which may be a sensitive measure of confinement effects in QCD. Surprisingly though, the total K+ and π+ form factors differ by only 10%. In general we find that flavor breaking effects are typically around 20%.

  2. A cellular automaton model for microstructural simulation of friction stir welded AZ91 magnesium alloy

    NASA Astrophysics Data System (ADS)

    Akbari, Mostafa; Asadi, Parviz; Besharati Givi, MohammadKazem; Zolghadr, Parisa

    2016-03-01

    To predict the grain size and microstructure evolution during friction stir welding (FSW) of AZ91 magnesium alloy, a finite element model (FEM) is developed based on the combination of a cellular automaton model and the Kocks  -  Mecking and Laasraoui-Jonas models. First, according to the flow stress curves and using the Kocks  -  Mecking model, the hardening and recovery parameters and the strain rate sensitivity were calculated. Next, an FEM model was established in Deform-3D software to simulate the FSW of AZ91 magnesium alloy. The results of the FEM model are used in microstructure evolution models to predict the grain size and microstructure of the weld zone. There is a good agreement between the simulated and experimental microstructures, and the proposed model can simulate the dynamic recrystallization (DRX) process during FSW of AZ91 alloy. Moreover, microstructural properties of different points in the SZ as well as the effect of the w/v parameter on the grain size and microstructure are considered.

  3. Dual use and the ethical responsibility of scientists.

    PubMed

    Ehni, Hans-Jörg

    2008-01-01

    The main normative problem in the context of dual use is to determine the ethical responsibility of scientists especially in the case of unintended, harmful, and criminal dual use of new technological applications of scientific results. This article starts from an analysis of the concepts of responsibility and complicity, examining alternative options regarding the responsibility of scientists. Within the context of the basic conflict between the freedom of science and the duty to avoid causing harm, two positions are discussed: moral skepticism and the ethics of responsibility by Hans Jonas. According to these reflections, four duties are suggested and evaluated: stopping research, systematically carrying out research for dual-use applications, informing public authorities, and not publishing results. In the conclusion it is argued that these duties should be considered as imperfect duties in a Kantian sense and that the individual scientist should be discharged as much as possible from obligations which follow from them by the scientific community and institutions created for this purpose. PMID:18512027

  4. Chiral nucleon-Δ using the coherent-pion pair approximation

    NASA Astrophysics Data System (ADS)

    Sayed Aly, Tarek; McNeil, J. A.

    1996-10-01

    Despite significant strides in the numerical assault on QCD, this candidate theory of the strong interactions remains a computational challenge and models incorporating its important symmetries remain attractive alternatives for gaining insight into the nucleon problem. One such class of models which does not incorporate confinement but does respect chiral symmetry is the Nambu-Jona-Lasinio model and in particular its bosonized variant, the linear sigma model using quarks and mesonic degrees of freedom. About a decade ago several groups made significant progress in understanding fundamental nucleon properties using such models. In this work we re-visit one such effort undertaken by K. Goeke et al.(K. Goeke, M. Harvey, F. Grümmer, and J. N. Urbano, Phys. Rev. D37), 754 (1988). who computed nucleon and Δ properties using the so-called coherent pair approximation to treat the quantum nature of the pion field in a more realistic fashion. In rederiving their equations we have discovered some discrepancies in the treatment of the coherent pair Fock states. In this work we present alternative equations for the coherent-pair states. Numerical work to evaluate the new equations for the nucleon-Δ sector are underway.

  5. From quark drops to quark stars. Some aspects of the role of quark matter in compact stars

    NASA Astrophysics Data System (ADS)

    Lugones, Germán

    2016-03-01

    We review some recent results about the mechanism of deconfinement of hadronic matter into quark matter in cold neutron stars and protoneutron stars. We discuss the role of finite-size effects and the relevance of temperature and density fluctuations on the nucleation process. We also examine the importance of surface effects for mixed phases in hybrid stars. A small drop of quark matter nucleated at the core of a compact star may grow if the conversion is sufficiently exothermic. In such a case, it may trigger the burning of the stellar core and even the whole star if quark matter is absolutely stable. We explore the physical processes that occur inside the flame and analyze the hydrodynamic evolution of the combustion front. In the last part of this review, we focus on hybrid stars using the Nambu-Jona-Lasinio (NJL) model with scalar, vector and 't Hooft interactions, paying particular attention to a generalized non-standard procedure for the choice of the "bag constant". We also describe the non-radial oscillation modes of hadronic, hybrid and strange stars with maximum masses above 2M_{odot} and show that the frequency of the p1 and g fluid modes contains key information about the internal composition of compact objects.

  6. Critical spectrum of fluctuations for deconfinement at protoneutron star cores

    SciTech Connect

    Lugones, G.; Grunfeld, A. G.

    2011-10-15

    We study the deconfinement of hadronic matter into quark matter in a protoneutron star focusing on the effects of the finite size on the formation of just deconfined color superconducting quark droplets embedded in the hadronic environment. The hadronic phase is modeled by the nonlinear Walecka model at finite temperature including the baryon octet and neutrino trapping. For quark matter we use an SU(3){sub f} Nambu-Jona-Lasinio model including color superconductivity. The finite size effects on the just deconfined droplets are considered in the frame of the multiple reflection expansion. In addition, we consider that just deconfined quark matter is transitorily out of equilibrium respect to weak interaction, and we impose color neutrality and flavor conservation during the transition. We calculate self-consistently the surface tension and curvature energy density of the quark hadron interphase and find that it is larger than the values typically assumed in the literature. The transition density is calculated for drops of different sizes, and at different temperatures and neutrino trapping conditions. Then, we show that energy density fluctuations are much more relevant for deconfinement than temperature and neutrino density fluctuations. We calculate the critical size spectrum of energy density fluctuations that allows deconfinement as well as the nucleation rate of each critical bubble. We find that drops with any radii smaller than 800 fm can be formed at a huge rate when matter achieves the bulk transition limit of 5-6 times the nuclear saturation density.

  7. Holographic Schwinger effect and chiral condensate in SYM theory

    NASA Astrophysics Data System (ADS)

    Ghoroku, Kazuo; Ishihara, Masafumi

    2016-09-01

    We study the instability, for the supersymmetric Yang-Mills (SYM) theories, caused by the external electric field through the imaginary part of the action of the D7 probe brane, which is embedded in the background of type IIB theory. This instability is related to the Schwinger effect, namely to the quark pair production due to the external electric field, for the SU( N c ) SYM theories. In this holographic approach, it is possible to calculate the Schwinger effect for various phases of the theories. Here we give the calculation for {N}=2 SYM theory and the analysis is extended to the finite temperature deconfinement and the zero temperature confinement phases of the Yang-Mills (YM) theory. By comparing the obtained production rates with the one of the supersymmetric case, the dynamical quark mass is estimated and we find how it varies with the chiral condensate. Based on this analysis, we give a speculation on the extension of the Nambu-Jona-Lasinio model to the finite temperature YM theory, and four fermi coupling is evaluated in the confinement theory.

  8. Determination of hadron-quark phase transition line from lattice QCD and two-solar-mass neutron star observations

    NASA Astrophysics Data System (ADS)

    Sugano, Junpei; Kouno, Hiroaki; Yahiro, Masanobu

    2016-07-01

    We aim at drawing the hadron-quark phase transition line in the QCD phase diagram by using the two-phase model (TPM) in which the entanglement Polyakov-loop extended Nambu-Jona-Lasinio (EPNJL) model with the vector-type four-quark interaction is used for the quark phase and the relativistic mean field (RMF) model is used for the hadron phase. A reasonable TPM is constructed by using lattice QCD data and neutron star observations as reliable constraints. For the EPNJL model, we determine the strength of vector-type four-quark interaction at zero quark chemical potential from lattice QCD data on quark number density normalized by its Stefan-Boltzmann limit. For the hadron phase, we consider three RMF models: NL3; TM1; and the model proposed by Maruyama, Tatsumi, Endo, and Chiba (MTEC). We find that MTEC is most consistent with the neutron star observations and TM1 is the second best. Assuming that the hadron-quark phase transition occurs in the core of a neutron star, we explore the density dependence of vector-type four-quark interaction. Particularly for the critical baryon chemical potential μBc at zero temperature, we determine a range of μBc for the quark phase to occur in the core of a neutron star. The values of μBc lie in the range 1560 MeV ≤μBc≤1910 MeV .

  9. Neutrality of a magnetized two-flavor quark superconductor

    NASA Astrophysics Data System (ADS)

    Mandal, Tanumoy; Jaikumar, Prashanth

    2013-04-01

    We investigate the effect of electric and color charge neutrality on the two-flavor color superconducting (2SC) phase of cold and dense quark matter in presence of constant external magnetic fields and at moderate baryon densities. Within the framework of the Nambu-Jona-Lasinio (NJL) model, we study the interdependent evolution of the quark's BCS gap and constituent mass with increasing density and magnetic field. While confirming previous results derived for the highly magnetized 2SC phase with color neutrality alone, we obtain new results as a consequence of imposing charge neutrality. In the charge neutral gapless 2SC phase (g2SC), a large magnetic field drives the color superconducting phase transition to a crossover, while the chiral phase transition is first order. At larger diquark-to-scalar coupling ratio GD/GS, where the 2SC phase is preferred, we see hints of the Clogston-Chandrasekhar limit at a very large value of the magnetic field (B˜1019G), but this limit is strongly affected by Shubnikov de Haas-van Alphen oscillations of the gap, indicating the transition to a domain-like state.

  10. The dynamical composite Higgs

    NASA Astrophysics Data System (ADS)

    von Gersdorff, Gero; Pontón, Eduardo; Rosenfeld, Rogerio

    2015-06-01

    We present a simple microscopic realization of a pseudo-Nambu-Goldstone (pNGB) boson Higgs scenario arising from the breaking of SO(5) → SO(4). The Higgs constituents are explicitly identified as well as the interactions responsible for forming the bound state and breaking the electroweak symmetry. This outcome follows from the presence of four-fermion interactions with a super-critical coupling, and uses the Nambu-Jona-Lasinio mechanism to break the global SO(5) symmetry. The Higgs potential is found to be insensitive to high energy scales due to the existence of an approximate infrared fixed point. The appearance of vector resonances is described and the correspondence with other proposals in the literature established. The model described here is significantly simpler than other recent ultraviolet completions of pNGB scenarios. The observed Higgs mass can be accommodated, and agreement with electroweak precision tests achieved in certain regions of parameter space. There are also new vector-like fermions, some of which may lie within reach of the LHC. In addition, we predict a heavy standard model singlet scalar in the multi-TeV range. The amount of fine-tuning required in the model is studied. Finally, we show that such a scheme can be completed in the ultraviolet by a renormalizable theory.

  11. Inhomogeneity driven by Higgs instability in a gapless superconductor

    SciTech Connect

    Giannakis, Ioannis; Hou Defu; Huang Mei; Ren Haicang

    2007-01-01

    The fluctuations of the Higgs and pseudo Nambu-Goldstone fields in the 2-flavor color superconductivity (2SC) phase with mismatched pairing are described in the nonlinear realization framework of the gauged Nambu-Jona-Lasinio model. In the gapless 2SC phase, not only Nambu-Goldstone currents can be spontaneously generated, but also the Higgs field exhibits instablity. The Nambu-Goldstone currents generation indicates the formation of the single plane wave Larkin-Ovchinnikov-Fulde-Ferrel state and breaks rotation symmetry, while the Higgs instability favors spatial inhomogeneity and breaks translation invariance. In this paper, we focus on the Higgs instability which has not drawn much attention yet. The Higgs instability cannot be removed without a long range force, thus it persists in the gapless superfluidity and induces phase separation. In the case of gapless 2-flavor color superconductivity state, the Higgs instability can only be partially removed by the electric Coulomb energy. However, it is not excluded that the Higgs instability might be completely removed in the charge neutral gapless color-flavor locked phase by the color Coulomb energy.

  12. [Sigmund Freud and the "Zeitschrift für Hypnotismus"].

    PubMed

    Tanner, Terence A

    2005-01-01

    While Freud was always ready to acknowledge the debt that psychoanalysis owed to hypnotism, his engagement in its study and medical application is often seen by historians as little more than a passing phase on the way to psychoanalysis proper. This paper attempts to redress the balance by exploring Freud's association with the most influential German-language journal devoted to hypnotism, the Zeitschrift für Hypnotismus. Freud not only contributed a paper to this periodical but also served on its editorial board for the first three years of its existence. There also appeared in the journal one review and six abstracts of his work. After a condensed bibliographical account of the journal, a summary is given of Freud's intellectual and professional contacts and exchanges with three of the key individuals associated with it: August Forel, Jonas Grossmann and Oskar Vogt. Finally clarification is given of the publication history of the "Dora" case history and the chronology of its rejection for publication by Korbinian Brodmann, editor of the journal when it became the Journal für Psychologie und Neurologie.

  13. Quark matter in a parallel electric and magnetic field background: Chiral phase transition and equilibration of chiral density

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.

    2016-05-01

    In this article, we study spontaneous chiral symmetry breaking for quark matter in the background of static and homogeneous parallel electric field E and magnetic field B . We use a Nambu-Jona-Lasinio model with a local kernel interaction to compute the relevant quantities to describe chiral symmetry breaking at a finite temperature for a wide range of E and B . We study the effect of this background on the inverse catalysis of chiral symmetry breaking for E and B of the same order of magnitude. We then focus on the effect of the equilibration of chiral density n5 , produced dynamically by an axial anomaly on the critical temperature. The equilibration of n5 , a consequence of chirality-flipping processes in the thermal bath, allows for the introduction of the chiral chemical potential μ5, which is computed self-consistently as a function of the temperature and field strength by coupling the number equation to the gap equation and solving the two within an expansion in E /T2 , B /T2 , and μ52/T2 . We find that even if chirality is produced and equilibrates within a relaxation time τM , it does not change drastically the thermodynamics, with particular reference to the inverse catalysis induced by the external fields, as long as the average μ5 at equilibrium is not too large.

  14. Holographic Schwinger effect and chiral condensate in SYM theory

    NASA Astrophysics Data System (ADS)

    Ghoroku, Kazuo; Ishihara, Masafumi

    2016-09-01

    We study the instability, for the supersymmetric Yang-Mills (SYM) theories, caused by the external electric field through the imaginary part of the action of the D7 probe brane, which is embedded in the background of type IIB theory. This instability is related to the Schwinger effect, namely to the quark pair production due to the external electric field, for the SU( N c ) SYM theories. In this holographic approach, it is possible to calculate the Schwinger effect for various phases of the theories. Here we give the calculation for N=2 SYM theory and the analysis is extended to the finite temperature deconfinement and the zero temperature confinement phases of the Yang-Mills (YM) theory. By comparing the obtained production rates with the one of the supersymmetric case, the dynamical quark mass is estimated and we find how it varies with the chiral condensate. Based on this analysis, we give a speculation on the extension of the Nambu-Jona-Lasinio model to the finite temperature YM theory, and four fermi coupling is evaluated in the confinement theory.

  15. Response of nucleons to external probes in hedgehog models. I. Electromagnetic polarizabilities

    NASA Astrophysics Data System (ADS)

    Broniowski, Wojciech; Cohen, Thomas D.

    1993-01-01

    Electromagnetic polarizabilities of the nucleon are analyzed in a hedgehog model with quark and meson degrees of freedom. Semiclassical methods are used (linear response theory, quantization via cranking). It is found that in hedgehog models (Skyrmion, chiral quark models, Nambu-Jona-Lasinio model), the average electric polarizability of the nucleon, αN, is of the order Nc, and the splitting of the neutron and proton electric (proper) polarizabilities, δα=αn-αp, is of the order 1/Nc. We present a general argument why one expects δα>0 in models with a pionic cloud. Our model prediction for the sign and magnitude of δα is in agreement with recent measurements. The obtained value for αN, however, is roughly a factor of 3 too large. This is because of two problems with our particular model: a too strong pion tail and the degeneracy of N and Δ states in the large-Nc limit. This degeneracy also results in a very strong Nc dependence of the paramagnetic part of the magnetic polarizability β, which is of the order N3c. We compare the large-Nc results to the one-loop chiral perturbation theory predictions, and show the importance of Δ effects in pionic loops. We also investigate the role of nonminimal substitution terms in the effective Lagrangian on the polarizabilities of the nucleon.

  16. Impaired activation of platelets lacking protein kinase C-theta isoform.

    PubMed

    Nagy, Bela; Bhavaraju, Kamala; Getz, Todd; Bynagari, Yamini S; Kim, Soochong; Kunapuli, Satya P

    2009-03-12

    Protein kinase C (PKC) isoforms have been implicated in several platelet functional responses, but the contribution of individual isoforms has not been thoroughly evaluated. Novel PKC isoform PKC-theta is activated by glycoprotein VI (GPVI) and protease-activated receptor (PAR) agonists, but not by adenosine diphosphate. In human platelets, PKC-theta-selective antagonistic (RACK; receptor for activated C kinase) peptide significantly inhibited GPVI and PAR-induced aggregation, dense and alpha-granule secretion at low agonist concentrations. Consistently, in murine platelets lacking PKC-theta, platelet aggregation and secretion were also impaired. PKC-mediated phosphorylation of tSNARE protein syntaxin-4 was strongly reduced in human platelets pretreated with PKC-theta RACK peptide, which may contribute to the lower levels of granule secretion when PKC-theta function is lost. Furthermore, the level of JON/A binding to activated alpha(IIb)beta(3) receptor was also significantly decreased in PKC-theta(-/-) mice compared with wild-type littermates. PKC-theta(-/-) murine platelets showed significantly lower agonist-induced thromboxane A(2) (TXA(2)) release through reduced extracellular signal-regulated kinase phosphorylation. Finally, PKC-theta(-/-) mice displayed unstable thrombus formation and prolonged arterial occlusion in the FeCl(3) in vivo thrombosis model compared with wild-type mice. In conclusion, PKC-theta isoform plays a significant role in platelet functional responses downstream of PAR and GPVI receptors. PMID:19164598

  17. Prospective Technology Assessment of Synthetic Biology: Fundamental and Propaedeutic Reflections in Order to Enable an Early Assessment.

    PubMed

    Schmidt, Jan Cornelius

    2016-08-01

    Synthetic biology is regarded as one of the key technosciences of the future. The goal of this paper is to present some fundamental considerations to enable procedures of a technology assessment (TA) of synthetic biology. To accomplish such an early "upstream" assessment of a not yet fully developed technology, a special type of TA will be considered: Prospective TA (ProTA). At the center of ProTA are the analysis and the framing of "synthetic biology," including a characterization and assessment of the technological core. The thesis is that if there is any differentia specifica giving substance to the umbrella term "synthetic biology," it is the idea of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called "late-modern technology." -I start this paper by analyzing the three most common visions of synthetic biology. Then I argue that one particular vision deserves more attention because it underlies the others: the vision of self-organization. I discuss the inherent limits of this new type of late-modern technology in the attempt to control and monitor possible risk issues. I refer to Hans Jonas' ethics and his early anticipation of the risks of a novel type of technology. I end by drawing conclusions for the approach of ProTA towards an early societal shaping of synthetic biology.

  18. Pion and σ-meson Properties in a Strong Magnetic Field

    NASA Astrophysics Data System (ADS)

    Zhang, Rui; Fu, Wei-Jie; Liu, Yu-Xin

    2015-09-01

    With the Nambu-Jona-Lasinio (NJL) model we calculate the properties of pion and σ-meson at finite temperature and finite magnetic field. The obtained temperature and magnetic field strength dependence of the constituent quark mass M, the pion and σ-meson masses and the neutral pion decay constant indicates that, in the simple four fermion interaction model, there exists the magnetic catalysis effect. It also shows that the Gell-Mann-Oakes-Renner relation is violated obviously with the increasing of the temperature, and the effect of the magnetic field becomes pronounced only around the critical temperature. The deviation of the critical temperatures obtained with different criteria indicates that the chiral phase transition driven by the temperature in the magnetic field strength region we have considered is in fact a crossover. Supported by the National Natural Science Foundation of China under Grant Nos. 10935001, 11175004, and 11435001, and the National Key Basic Research Program of China under Grant Nos. G2013CB834400 and G2015CB856900

  19. Effect of temperature and magnetic field on two-flavor superconducting quark matter

    NASA Astrophysics Data System (ADS)

    Mandal, Tanumoy; Jaikumar, Prashanth

    2016-10-01

    We investigate the effect of turning on temperature for the charge neutral phase of two-flavor color superconducting (2SC) dense quark matter in the presence of constant external magnetic field. Within the Nambu-Jona-Lasinio model, by tuning the diquark coupling strength, we study the interdependent evolution of the quark Bardeen-Cooper-Schrieffer gap and dynamical mass as functions of temperature and magnetic field. We find that magnetic field B ≳0.02 GeV2 (1 018 G ) leads to anomalous temperature behavior of the gap in the gapless 2SC phase (moderately strong coupling), reminiscent of previous results in the literature found in the limit of weak coupling without magnetic field. The 2SC gap in the strong coupling regime is abruptly quenched at ultrahigh magnetic field due to the mismatched Fermi surfaces of up and down quarks imposed by charge neutrality and oscillation of the gap due to Landau level quantization. The dynamical quark mass also displays strong oscillation and magnetic catalysis at high magnetic field, although the latter effect is tempered by nonzero temperature. We discuss the implications for newly born compact stars with superconducting quark cores.

  20. What you don't know about vaccines can hurt you.

    PubMed

    Pace, Victor M

    2015-01-01

    As physicians, we've all learned in detail about the science behind vaccinations, but I suspect few of us have been taught about the history of vaccinations. Sure, we all know that Dr. Jonas Salk developed the poliovirus vaccine, but I wasn't aware that he inoculated himself, his wife, and his three children with his then experimental vaccine. When our editorial committee decided to focus on vaccinations as our theme for this month's Greene County Medical Society's Journal, I perused the internet for interesting topics. I came across a fascinating website, historyofvaccines.org; this website is a project of the College of Physicians of Philadelphia, touted as being the oldest professional medical organization in the United States. I credit the majority of the information in this article to the above website and the rest to the National Institutes of Health (nih.gov) website; I trust that the information is valid and true, based on the agencies behind these websites. Below are some interesting tidbits about vaccine preventable diseases that I found noteworthy to pass on to our readers.

  1. Phase transition of strongly interacting matter with a chemical potential dependent Polyakov loop potential

    NASA Astrophysics Data System (ADS)

    Shao, Guo-yun; Tang, Zhan-duo; Di Toro, Massimo; Colonna, Maria; Gao, Xue-yan; Gao, Ning

    2016-07-01

    We construct a hadron-quark two-phase model based on the Walecka-quantum hadrodynamics and the improved Polyakov-Nambu-Jona-Lasinio (PNJL) model with an explicit chemical potential dependence of Polyakov loop potential (μ PNJL model). With respect to the original PNJL model, the confined-deconfined phase transition is largely affected at low temperature and large chemical potential. Using the two-phase model, we investigate the equilibrium transition between hadronic and quark matter at finite chemical potentials and temperatures. The numerical results show that the transition boundaries from nuclear to quark matter move towards smaller chemical potential (lower density) when the μ -dependent Polyakov loop potential is taken. In particular, for charge asymmetric matter, we compute the local asymmetry of u , d quarks in the hadron-quark coexisting phase, and analyze the isospin-relevant observables possibly measurable in heavy-ion collision (HIC) experiments. In general new HIC data on the location and properties of the mixed phase would bring relevant information on the expected chemical potential dependence of the Polyakov loop contribution.

  2. Toward a first-principle derivation of confinement and chiral-symmetry-breaking crossover transitions in QCD

    NASA Astrophysics Data System (ADS)

    Kondo, Kei-Ichi

    2010-09-01

    We give a theoretical framework to obtain a low-energy effective theory of quantum chromodynamics (QCD) towards a first-principle derivation of confinement/deconfinement and chiral-symmetry breaking/restoration crossover transitions. In fact, we demonstrate that an effective theory obtained using simple but nontrivial approximations within this framework enables us to treat both transitions simultaneously on equal footing. A resulting effective theory is regarded as a modified and improved version of nonlocal Polyakov-loop extended Nambu-Jona-Lasinio (nonlocal PNJL) models proposed recently by Hell, Rössner, Cristoforetti, and Weise, and Sasaki, Friman, and Redlich, extending the original (local) PNJL model by Fukushima and others. A novel feature is that the nonlocal NJL coupling depends explicitly on the temperature and Polyakov loop, which affects the entanglement between confinement and chiral-symmetry breaking, together with the cross term introduced through the covariant derivative in the quark sector considered in the conventional PNJL model. The chiral-symmetry breaking/restoration transition is controlled by the nonlocal NJL interaction, while the confinement/deconfinement transition in the pure gluon sector is specified by the nonperturbative effective potential for the Polyakov loop obtained recently by Braun, Gies, Marhauser, and Pawlowski. The basic ingredients are a reformulation of QCD based on new variables and the flow equation of the Wetterich type in the Wilsonian renormalization group. This framework can be applied to investigate the QCD phase diagram at finite temperature and density.

  3. Isentropic thermodynamics and scalar-mesons properties near the QCD critical end point

    NASA Astrophysics Data System (ADS)

    Costa, Pedro

    2016-08-01

    We investigate the QCD phase diagram and the location of the critical end point (CEP) in the SU(2) Polyakov-Nambu-Jona-Lasinio model with entanglement interaction giving special attention to the π and σ-mesons properties, namely the decay widths σ→ππ, for several conditions around the CEP: we focus on the possible σ→ππ decay along the isentropic trajectories close to the CEP since the hydrodynamical expansion of a heavy-ion collision fireball nearly follows trajectories of constant entropy. It is expected that the type of transition the dense medium goes through as it expands after the thermalization determines the behavior of this decay. It is shown that no pions are produced from the sigma decay in the chirally symmetric phase if the isentropic lines approach the first-order line from chemical potentials above it. Near the CEP or above the σ→ππ decay is possible with a high decay width.

  4. Nambu mechanism of dynamical symmetry breaking by the top quark

    NASA Astrophysics Data System (ADS)

    Pham, Xuan-Yem

    1990-05-01

    It may be possible that the gauge symmetry breaking of the standard electroweak interactions is not due to the elementary scalar Higgs fields but has a dynamic origin intimately involving the top quark. A prototype of this dynamical scenario is the Nambu and Jona-Lasinio model in which both the top quark and the gauge bosons become massive by some strong attractive nonlinear interactions similar to the gap energy produced in BCS superconductivity. Self-consistent equations for the charged Goldstone boson and for the vector meson are used to get an upper bound for the top quark mass. In the bubble approximation of keeping only fermion loops, we obtain an equation relating the top quark mass to the W boson one; from the top mass is found to be around 84 GeV. Its typical dominant decay mode t→W+s then follows. Also discussed are distinctive signatures of the scalar overlinett bound state identified as the physical Higgs particle whose mass is twice that of the top quark.

  5. Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Integrin β3-Dependent Pathway in Mice

    PubMed Central

    Jin, Shuqing; Chen, Zhixia; Ding, Xibing; Zhao, Xiang; Jiang, Xi; Tong, Yao; Billiar, Timothy R; Li, Quan

    2016-01-01

    Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an analogue of natural double-strand RNA virus, can induce lung inflammation. The purpose of this study was to determine whether moderate tidal volume mechanical ventilation (MTV) augments poly(I:C)-induced lung injury, and if so, the mechanism responsible for it. Two μg/g poly(I:C) were instilled intratracheally in C57BL/6J wide type (WT) mice. They were then randomized to MTV (10 ml/kg tidal volume) or spontaneous breathing. Lung tissues and bronchoalveolar lavage fluid (BALF) were collected 4 h later for various measurements. Our results showed that MTV did not cause significant injury in normal lungs, but augmented poly(I:C)-induced lung injury. The expression level of WNT-induced secreted protein 1 (WISP1) was consistent with lung injury, and the amplification of lung injury by MTV could be alleviated by anti-WISP1 antibody treatment. MTV further increased poly(I:C)-induced integrin β3 expression in the lung. We performed coimmunoprecipitation, which showed there was an interaction between WISP1 and β3. WISP1 significantly increased poly(I:C)-induced TNF-α production in macrophages isolated from WT mice, but not in macrophages isolated from β3 knockout mice. Cotreatment with WISP1 and poly(I:C) markedly increased the phosphorylation of extracellular signal-related kinase (ERK) in macrophages. Pretreating macrophages with an ERK inhibitor, U0126, dose-dependently antagonized the synergistic effect of WISP1 on poly(I:C)-induced TNF-α release. In conclusion, MTV exaggerates poly(I:C)-induced lung injury in a WISP1- and integrin β3-dependent manner, involving, at least in part, the activation of the ERK pathway. The WISP1-integrin β3 pathway could be a novel therapeutic target. PMID:26772774

  6. Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression

    PubMed Central

    Romas, Laura; Birse, Kenzie; Mayer, Kenneth H.; Abou, Max; Westmacott, Garrett; Giguere, Rebecca; Febo, Irma; Cranston, Ross D.; Carballo-Diéguez, Alex; McGowan, Ian

    2016-01-01

    Abstract Rectal use of a 1% tenofovir (TFV) gel is currently being evaluated for HIV prevention. While careful assessment of mucosal safety of candidate microbicides is a primary concern, tools to assess mucosal toxicity are limited. Mass spectrometry-based proteomics is a sensitive and high-throughput technique that can provide in-depth information on inflammation processes in biological systems. In this study, we utilized a proteomics approach to characterize mucosal responses in study participants involved in a phase 1 clinical trial of a rectal TFV-based gel. Project Gel was a phase 1 randomized (1:1), double-blind, multisite, placebo-controlled trial in which 24 participants received rectal TFV or a universal placebo [hydroxyethyl cellulose (HEC)] over a course of 8 daily doses. Rectal mucosal swabs were collected after 0, 1, and 8 doses and were analyzed by label-free tandem mass spectrometry. Differential protein expression was evaluated using a combination of paired (time-effects) and unpaired (across study arm) t-tests, and multivariate [least absolute shrinkage and selection operator (LASSO)] modeling. Within the TFV arm, 7% (17/249, p < .05) and 10% (25/249, p < .05) of total proteins changed after 1 and 8 daily applications of TFV gel, respectively, compared to 3% (7/249, p < .05) and 6% (16/249, p < .05) in the HEC arm. Biofunctional analysis associated TFV use with a decrease in epidermal barrier proteins (adj. p = 1.21 × 10−10). Multivariate modeling identified 13 proteins that confidently separated TFV gel users (100% calibration and 96% cross-validation accuracy), including the epithelial integrity factors (FLMNB, CRNN, CALM), serpins (SPB13, SPB5), and cytoskeletal proteins (VILI, VIME, WRD1). This study suggested that daily rectal applications of a 1% TFV gel may be associated with mucosal proteome changes involving epidermal development. Further assessment of more extended use of TFV-gel is recommended to validate

  7. Recruitment Maneuver Does not Increase the Risk of Ventilator Induced Lung Injury

    PubMed Central

    Akıncı, İbrahim Özkan; Atalan, Korkut; Tuğrul, Simru; Özcan, Perihan Ergin; Yılmazbayhan, Dilek; Kıran, Bayram; Basel, Ahmet; Telci, Lutfi; Çakar, Nahit

    2013-01-01

    Background: Mechanical ventilation (MV) may induce lung injury. Aims: To assess and evaluate the role of different mechanical ventilation strategies on ventilator-induced lung injury (VILI) in comparison to a strategy which includes recruitment manoeuvre (RM). Study design: Randomized animal experiment. Methods: Thirty male Sprague-Dawley rats were anaesthetised, tracheostomised and divided into 5 groups randomly according to driving pressures; these were mechanically ventilated with following peak alveolar opening (Pao) and positive end-expiratory pressures (PEEP) for 1 hour: Group 15-0: 15 cmH2O Pao and 0 cmH2O PEEP; Group 30-10: 30 cmH2O Pao and 10 cmH2O PEEP; Group 30-5: 30 cmH2O Pao and 5 cmH2O PEEP; Group 30-5&RM: 30 cmH2O Pao and 5 cmH2O PEEP with additional 45 cmH2O CPAP for 30 seconds in every 15 minutes; Group 45-0: 45 cmH2O Pao and 0 cmH2O PEEP Before rats were sacrificed, blood samples were obtained for the evaluation of cytokine and chemokine levels; then, the lungs were subsequently processed for morphologic evaluation. Results: Oxygenation results were similar in all groups; however, the groups were lined as follows according to the increasing severity of morphometric evaluation parameters: Group 15-0: (0±0.009) < Group 30-10: (0±0.14) < Group 30-5&RM: (1±0.12) < Group 30-5: (1±0.16) < Group 45-0: (2±0.16). Besides, inflammatory responses were the lowest in 30-5&RM group compared to all other groups. TNF-α, IL-1β, IL-6, MCP-1 levels were significantly different between group 30-5&RM and group 15-0 vs. group 45-0 in each group. Conclusion: RM with low PEEP reduces the risk of ventilator-induced lung injury with a lower release of systemic inflammatory mediators in response to mechanical ventilation. PMID:25207105

  8. Jeff Levin, MPH, PhD. The power of love. Interview by Bonnie Horrigan.

    PubMed

    Levin, J

    1999-07-01

    Jeff Levin is an epidemiologist and writer living in Kansas. He was trained in religion, sociology, public health, preventive medicine, and gerontology at Duke University, the University of North Carolina, the University of Texas Medical Branch, and the University of Michigan. From 1989 to 1997 he served on the faculty of the Department of Family and Community Medicine at Eastern Virginia Medical School in Norfolk, Va. Dr Levin pioneered basic research on the epidemiology of religion. He has been funded by several National Institute of Health (NIH) grants, totaling more than $1 million in support. He has also received funding from private sources including the American Medical Association and the Institute of Noetic Sciences. Dr Levin is a senior research fellow of the National Institute for Healthcare Research; an advisory board member of the Center on Aging, Religion, and Spirituality; and past president of the International Society for the Study of Subtle Energies and Energy Medicine. He has been chair of the NIH Working Group on Quantitative Methods in Alternative Medicine, is a former member of the NIH Workgroup on Measures of Religiousness and Spirituality, and is a member of the editorial boards of several peer-reviewed scientific journals including Alternative Therapies. Dr Levin is the author of more than 110 scholarly publications, including 5 books. These include his edited book Religion in Aging and Health (Sage Publications); the newly published Essentials of Complementary and Alternative Medicine (Lippincott, Williams & Wilkins), which he edited with Dr Wayne Jonas; and the forthcoming God, Faith, and Health (John Wiley & Sons). Alternative Therapies interviewed Dr Levin at his home in Topeka, Kan, where he lives with his wife, Dr Lea Steele Levin.

  9. Wdr1-Dependent Actin Reorganization in Platelet Activation.

    PubMed

    Dasgupta, Swapan K; Le, Anhquyen; Da, Qi; Cruz, Miguel; Rumbaut, Rolando E; Thiagarajan, Perumal

    2016-01-01

    In resting platelets, the integrin αIIbβ3 is present in a low-affinity "bent" state. During platelet aggregation, intracytoplasmic signals induce conformational changes (inside-out signaling) that result in a "swung-out" conformation competent to bind ligands such as fibrinogen. The cytoskeleton plays an essential role in αIIbβ3 activation. We investigated the role of the actin interacting protein Wdr1 in αIIbβ3 activation. Wdr1-hypomorphic mice had a prolonged bleeding time (> 10 minutes) compared to that of wild-type mice (2.1 ± 0.7 minutes). Their platelets had impaired aggregation to collagen and thrombin. In a FeCl3 induced carotid artery thrombosis model, vessel occlusion in Wdr1-hypomorphic mice was prolonged significantly compared to wild-type mice (9.0 ± 10.5 minutes versus 5.8 ± 12.6 minutes (p = 0.041). Activation-induced binding of JON/A (a conformation-specific antibody to activated αIIbβ3) was significantly less in Wdr1-hypomorphic platelets at various concentrations of collagen, indicating impaired inside-out activation of αIIbβ3, despite a normal calcium response. Actin turnover, assessed by measuring F-actin and G-actin ratios during collagen- and thrombin-induced platelet aggregation, was highly impaired in Wdr1-hypomorphic platelets. Furthermore, talin failed to redistribute and translocate to the cytoskeleton following activation in Wdr1-hypomorphic platelets. These studies show that Wdr1 is essential for talin-induced activation of αIIbβ3 during platelet activation. PMID:27627652

  10. Dynamical generation of a repulsive vector contribution to the quark pressure

    NASA Astrophysics Data System (ADS)

    Restrepo, Tulio E.; Macias, Juan Camilo; Pinto, Marcus Benghi; Ferrari, Gabriel N.

    2015-03-01

    Lattice QCD results for the coefficient c2 appearing in the Taylor expansion of the pressure show that this quantity increases with the temperature towards the Stefan-Boltzmann limit. On the other hand, model approximations predict that when a vector repulsion, parametrized by GV, is present this coefficient reaches a maximum just after Tc and then deviates from the lattice predictions. Recently, this discrepancy has been used as a guide to constrain the (presently unknown) value of GV within the framework of effective models at large Nc (LN). In the present investigation we show that, due to finite Nc effects, c2 may also develop a maximum even when GV=0 since a vector repulsive term can be dynamically generated by exchange-type radiative corrections. Here we apply the optimized perturbation theory (OPT) method to the two-flavor Polyakov-Nambu-Jona-Lasinio model (at GV=0 ) and compare the results with those furnished by lattice simulations and by the LN approximation at GV=0 and also at GV≠0 . The OPT numerical results for c2 are impressively accurate for T ≲1.2 Tc but, as expected, they predict that this quantity develops a maximum at high T . After identifying the mathematical origin of this extremum we argue that such a discrepant behavior may naturally arise within this type of effective quark theories (at GV=0 ) whenever the first 1 /Nc corrections are taken into account. We then interpret this hypothesis as an indication that beyond the large-Nc limit the correct high-temperature (perturbative) behavior of c2 will be faithfully described by effective models only if they also mimic the asymptotic freedom phenomenon.

  11. Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia

    PubMed Central

    Nagy, Béla; Jin, Jianguo; Ashby, Barrie; Reilly, Michael P.; Kunapuli, Satya P.

    2011-01-01

    Summary Background In hypercholesterolemia, platelets demonstrate increased reactivity and promote the development of cardiovascular disease. Objective This study was carried out to investigate the contribution of the ADP receptor P2Y12-mediated pathway in platelet hyperreactivity due to hypercholesterolemia. Methods Low-density lipoprotein receptor deficient mice and C57Bl/6 wild type mice were fed on normal chow and high-fat (Western or Paigen) diets for 8 weeks to generate differently elevated cholesterol levels. P2Y12 receptor induced functional responses via Gi signaling were studied ex vivo when washed murine platelets were activated by 2MeSADP and PAR4 agonist AYPGKF in the presence and absence of indomethacin. Platelet aggregation, secretion, αIIbβ3 receptor activation and the phosphorylation of extracellular signal-regulated protein kinase (ERK) and Akt were analyzed. Results Plasma cholesterol levels ranged from 69±10 to 1011±185 mg/dl depending on diet in mice with different genotypes. Agonist-dependent aggregation, dense and α-granule secretion and JON/A binding were gradually and significantly (P < 0.05) augmented at low agonist concentration in correlation with the increasing plasma cholesterol levels even if elevated thromboxane generation was blocked. These functional responses were induced via increased level of Gi mediated ERK and Akt phosphorylation in hypercholesterolemic mice versus normocholesterolemic animals. In addition, blocking of the P2Y12 receptor by AR-C69931MX (Cangrelor) resulted in strongly reduced platelet aggregation in mice with elevated cholesterol levels compared to normocholesterolemic controls. Conclusions These data revealed that the P2Y12 receptor pathway was substantially involved in platelet hyperreactivity associated with mild and severe hypercholesterolemia. PMID:21261805

  12. A Flea on Schrödinger's Cat

    NASA Astrophysics Data System (ADS)

    Landsman, N. P. (Klaas); Reuvers, Robin

    2013-03-01

    We propose a technical reformulation of the measurement problem of quantum mechanics, which is based on the postulate that the final state of a measurement is classical; this accords with experimental practice as well as with Bohr's views. Unlike the usual formulation (in which the post-measurement state is a unit vector in Hilbert space), our version actually opens the possibility of admitting a purely technical solution within the confines of conventional quantum theory (as opposed to solutions that either modify this theory, or introduce unusual and controversial interpretative rules and/or ontologies). To that effect, we recall a remarkable phenomenon in the theory of Schrödinger operators (discovered in 1981 by Jona-Lasinio, Martinelli, and Scoppola), according to which the ground state of a symmetric double-well Hamiltonian (which is paradigmatically of Schrödinger's Cat type) becomes exponentially sensitive to tiny perturbations of the potential as ħ→0. We show that this instability emerges also from the textbook wkb approximation, extend it to time-dependent perturbations, and study the dynamical transition from the ground state of the double well to the perturbed ground state (in which the cat is typically either dead or alive, depending on the details of the perturbation). Numerical simulations show that adiabatically arising perturbations may (quite literally) cause the collapse of the wave-function in the classical limit. Thus, at least in the context of a simple mathematical model, we combine the technical and conceptual virtues of decoherence (which fails to solve the measurement problem but launches the key idea that perturbations may come from the environment) with those of dynamical collapse models à la grw (which do solve the measurement problem but are ad hoc), without sharing their drawbacks: single measurement outcomes are obtained (instead of merely diagonal reduced density matrices), and no modification of quantum mechanics is needed.

  13. Understanding QCD at high density from a Z3 -symmetric QCD-like theory

    NASA Astrophysics Data System (ADS)

    Kouno, Hiroaki; Kashiwa, Kouji; Takahashi, Junichi; Misumi, Tatsuhiro; Yahiro, Masanobu

    2016-03-01

    We investigate QCD at large μ /T by using Z3-symmetric S U (3 ) gauge theory, where μ is the quark-number chemical potential and T is temperature. We impose the flavor-dependent twist boundary condition on quarks in QCD. This QCD-like theory has the twist angle θ as a parameter, and agrees with QCD when θ =0 and becomes symmetric when θ =2 π /3 . For both QCD and the Z3-symmetric S U (3 ) gauge theory, the phase diagram is drawn in μ -T plane with the Polyakov-loop extended Nambu-Jona-Lasinio model. In the Z3-symmetric S U (3 ) gauge theory, the Polyakov loop φ is zero in the confined phase appearing at T ≲200 MeV and μ ≲300 MeV . The perfectly confined phase never coexists with the color superconducting (CSC) phase, since finite diquark condensate in the CSC phase breaks Z3 symmetry and then makes φ finite. When μ ≳300 MeV , the CSC phase is more stable than the perfectly confined phase at T ≲100 MeV . Meanwhile, the chiral symmetry can be broken in the perfectly confined phase, since the chiral condensate is Z3 invariant. Consequently, the perfectly confined phase is divided into the perfectly confined phase without chiral symmetry restoration in a region of μ ≲300 MeV and T ≲200 MeV and the perfectly confined phase with chiral symmetry restoration in a region of μ ≳300 MeV and 100 ≲T ≲200 MeV . At low temperature, the basic phase structure of Z3-symmetric QCD-like theory remains in QCD. Properties of the sign problem in Z3-symmetric theory are also discussed. We discuss a numerical framework to evaluate observables at θ =0 from those at θ =2 π /3 .

  14. Biomolecular simulation on thousands of processors

    NASA Astrophysics Data System (ADS)

    Phillips, James Christopher

    Classical molecular dynamics simulation is a generally applicable method for the study of biomolecular aggregates of proteins, lipids, and nucleic acids. As experimental techniques have revealed the structures of larger and more complex biomolecular machines, the time required to complete even a single meaningful simulation of such systems has become prohibitive. We have developed the program NAMD to simulate systems of 50,000--500,000 atoms efficiently with full electrostatics on parallel computers with 1000 and more processors. NAMD's scalability is achieved through latency tolerant adaptive message-driven execution and measurement-based load balancing. NAMD is implemented in C++ and uses object-oriented design and threads to shield the basic algorithms from the necessary complexity of high-performance parallel execution. Apolipoprotein A-I is the primary protein constituent of high density lipoprotein particles, which transport cholesterol in the bloodstream. In collaboration with A. Jonas, we have constructed and simulated models of the nascent discoidal form of these particles, providing theoretical insight to the debate regarding the lipid-bound structure of the protein. Recently, S. Sligar and coworkers have created 10 nm phospholipid bilayer nanoparticles comprising a small lipid bilayer disk solubilized by synthetic membrane scaffold proteins derived from apolipoprotein A-I. Membrane proteins may be embedded in the water-soluble disks, with various medical and technological applications. We are working to develop variant scaffold proteins that produce disks of greater size, stability, and homogeneity. Our simulations have demonstrated a significant deviation from idealized cylindrical structure, and are being used in the interpretation of small angle x-ray scattering data.

  15. Effective field theories of baryons and mesons, or, what do quarks do?

    SciTech Connect

    Keaton, G.L.

    1995-06-26

    This thesis is an attempt to understand the properties of the protons, pions and other hadrons in terms of their fundamental building blocks. In the first chapter the author reviews several of the approaches that have already been developed. The Nambu-Jona-Lasinio model offers the classic example of a derivation of meson properties from a quark Lagrangian. The chiral quark model encodes much of the intuition acquired in recent decades. The author also discusses the non-linear sigma model, the Skyrme model, and the constituent quark model, which is one of the oldest and most successful models. In the constituent quark model, the constituent quark appears to be different from the current quark that appears in the fundamental QCD Lagrangian. Recently it was proposed that the constituent quark is a topological soliton. In chapter 2 the author investigates this soliton, calculating its mass, radius, magnetic moment, color magnetic moment, and spin structure function. Within the approximations used, the magnetic moments and spin structure function cannot simultaneously be made to agree with the constituent quark model. In chapter 3 the author uses a different plan of attack. Rather than trying to model the constituents of the baryon, he begins with an effective field theory of baryons and mesons, with couplings and masses that are simply determined phenomenologically. Meson loop corrections to baryon axial currents are then computed in the 1/N expansion. It is already known that the one-loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by 1/N{sup 2}. To leading order, these corrections are exactly the same as would be calculated in the constituent quark model. This method therefore offers a different approach to the constituent quark.

  16. Comparison and significance of auroral studies during the Swedish and Russian bilateral expedition to Spitsbergen in 1899-1900

    NASA Astrophysics Data System (ADS)

    Chernouss, S.; Sandahl, I.

    2008-05-01

    Results of measurements and visual observations of aurora at Spitsbergen, carried out by the joint Swedish-Russian expedition during 1899-1900, are described. Auroral observations took place during the great bilateral Arc-of-Meridian expedition, which was patronized by the Swedish Royal Family and the Russian Imperial Family. The Russian-Swedish Arc-of-Meridian measurements were closely coordinated but auroral measurements from the two sites in the Spitsbergen Archipelago were almost independent of each other. The basic auroral data for our presentation are reports of the Russian astronomer Josef Sykora and the Swedish geophysicist Jonas Westman. Both scientists used similar types of photo cameras and spectrographs, which were the best at that time and were made in Potsdam by Toepfer. Detailed descriptions of the optical devices and the system of spectral calibration are presented. A Toepfer spectrograph, possibly the one used by Westman, is still kept at IRF in Kiruna. We present a comparative analysis of auroral data from the Russian and Swedish stations on three themes: visual observations of aurora, describing features of auroral forms and giving us statistical data on aurora occurrence and the heights of aurora, photos of aurora, and auroral spectra. It is shown that the observations contain enough data to construct an auroral oval and to determine the heights of aurora. The expedition obtained the first photographic observations of the aurora in the Arctic. The auroral spectra demonstrate a high spectral resolution and show not only the main auroral emissions in the blue-green spectral range but also some weak emissions in the violet and ultraviolet region. All data are interpreted from a modern point of view. The Russian-Swedish 1899-1900 expedition carried out the first complex auroral investigations in the Arctic using optical instruments and presented well documented data and new results.

  17. The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin alpha(IIb)beta3 in platelets.

    PubMed

    Wee, Janet L; Jackson, Denise E

    2005-12-01

    Previous studies have implicated the immunoglobulin (Ig)-immunoreceptor tyrosine-based inhibitory motif (ITIM) superfamily member platelet endothelial cell adhesion molecule-1 (PECAM-1) in the regulation of integrin function. While PECAM-1 has been demonstrated to play a role as an inhibitory coreceptor of immunoreceptor tyrosine-based activation motif (ITAM)-associated Fcgamma receptor IIa (FcgammaRIIa) and glycoprotein VI (GPVI)/FcR gamma-chain signaling pathways in platelets, its physiologic role in integrin alpha(IIb)beta3-mediated platelet function is unclear. In this study, we investigate the functional importance of PECAM-1 in murine platelets. Using PECAM-1-deficient mice, we show that the platelets have impaired "outside-in" integrin alpha(IIb)beta3 signaling with impaired platelet spreading on fibrinogen, failure to retract fibrin clots in vitro, and reduced tyrosine phosphorylation of focal adhesion kinase p125 (125FAK) following integrin alpha(IIb)beta3-mediated platelet aggregation. This functional integrin alpha(IIb)beta3 defect could not be attributed to altered expression of integrin alpha(IIb)beta3. PECAM-1-/- platelets displayed normal platelet alpha granule secretion, normal platelet aggregation to protease-activated receptor-4 (PAR-4), adenosine diphosphate (ADP), and calcium ionophore, and static platelet adhesion. In addition, PECAM-1-/- platelets displayed normal "inside-out" integrin alpha(IIb)beta3 signaling properties as demonstrated by normal agonist-induced binding of soluble fluoroscein isothiocyanate (FITC)-fibrinogen, JON/A antibody binding, and increases in cytosolic-free calcium and inositol (1,4,5)P3 triphosphate (IP3) levels. This study provides direct evidence that PECAM-1 is essential for normal integrin alpha(IIb)beta3-mediated platelet function and that disruption of PECAM-1 induced a moderate "outsidein" integrin alpha(IIb)beta3 signaling defect. PMID:16081692

  18. Anisotropic propagator for the Goldstone modes in color-flavor locked phase in the presence of a magnetic field

    NASA Astrophysics Data System (ADS)

    Sen, Srimoyee

    2015-07-01

    We consider the phase diagram of QCD at very high baryon density and at zero temperature in the presence of a strong magnetic field. The state of matter at such high densities and low temperatures is believed to be a phase known as the color-flavor locked phase which breaks color and electromagnetic gauge invariance, leaving a linear combination of them, denoted as U (1 )e m ˜ , unbroken. Of the nine quarks (three flavors and three colors), five are neutral under this unbroken generator and four are oppositely charged (two with a charge of +1 and two with -1 ). In the presence of a magnetic field corresponding to U (1 )em ˜, however, the properties of the condensate change and a new phase known as the magnetic color-flavor locked (MCFL) phase is realized. This phase breaks an approximate S U (3 )C×S U (2 )L×S U (2 )R×U (1 )B×U (1 )A- symmetry of the Lagrangian to S U (2 )C+L +R×U (1 )em ˜ giving rise to six Goldstone modes, five of which are pseudo Goldstone modes. These Goldstone modes are composed of excitations that correspond to both neutral quarks and charged quarks. Hence it is natural to expect that the propagators of these Goldstone modes are affected in the presence of a magnetic field, and their speed becomes considerably anisotropic. Although this anisotropy is self-evident from symmetry arguments, it has not been quantified yet. We calculate this anisotropy in the speed of the Goldstone modes using a Nambu-Jona-Lasinio model type of interaction between the quarks and comment on the impact of such anisotropic modes on transport properties of the MCFL phase.

  19. Wdr1-Dependent Actin Reorganization in Platelet Activation

    PubMed Central

    Dasgupta, Swapan K.; Le, Anhquyen; Da, Qi; Cruz, Miguel; Rumbaut, Rolando E.; Thiagarajan, Perumal

    2016-01-01

    In resting platelets, the integrin αIIbβ3 is present in a low-affinity “bent” state. During platelet aggregation, intracytoplasmic signals induce conformational changes (inside-out signaling) that result in a “swung-out” conformation competent to bind ligands such as fibrinogen. The cytoskeleton plays an essential role in αIIbβ3 activation. We investigated the role of the actin interacting protein Wdr1 in αIIbβ3 activation. Wdr1-hypomorphic mice had a prolonged bleeding time (> 10 minutes) compared to that of wild-type mice (2.1 ± 0.7 minutes). Their platelets had impaired aggregation to collagen and thrombin. In a FeCl3 induced carotid artery thrombosis model, vessel occlusion in Wdr1-hypomorphic mice was prolonged significantly compared to wild-type mice (9.0 ± 10.5 minutes versus 5.8 ± 12.6 minutes (p = 0.041). Activation-induced binding of JON/A (a conformation-specific antibody to activated αIIbβ3) was significantly less in Wdr1-hypomorphic platelets at various concentrations of collagen, indicating impaired inside-out activation of αIIbβ3, despite a normal calcium response. Actin turnover, assessed by measuring F-actin and G-actin ratios during collagen- and thrombin-induced platelet aggregation, was highly impaired in Wdr1-hypomorphic platelets. Furthermore, talin failed to redistribute and translocate to the cytoskeleton following activation in Wdr1-hypomorphic platelets. These studies show that Wdr1 is essential for talin-induced activation of αIIbβ3 during platelet activation. PMID:27627652

  20. Jeff Levin, MPH, PhD. The power of love. Interview by Bonnie Horrigan.

    PubMed

    Levin, J

    1999-07-01

    Jeff Levin is an epidemiologist and writer living in Kansas. He was trained in religion, sociology, public health, preventive medicine, and gerontology at Duke University, the University of North Carolina, the University of Texas Medical Branch, and the University of Michigan. From 1989 to 1997 he served on the faculty of the Department of Family and Community Medicine at Eastern Virginia Medical School in Norfolk, Va. Dr Levin pioneered basic research on the epidemiology of religion. He has been funded by several National Institute of Health (NIH) grants, totaling more than $1 million in support. He has also received funding from private sources including the American Medical Association and the Institute of Noetic Sciences. Dr Levin is a senior research fellow of the National Institute for Healthcare Research; an advisory board member of the Center on Aging, Religion, and Spirituality; and past president of the International Society for the Study of Subtle Energies and Energy Medicine. He has been chair of the NIH Working Group on Quantitative Methods in Alternative Medicine, is a former member of the NIH Workgroup on Measures of Religiousness and Spirituality, and is a member of the editorial boards of several peer-reviewed scientific journals including Alternative Therapies. Dr Levin is the author of more than 110 scholarly publications, including 5 books. These include his edited book Religion in Aging and Health (Sage Publications); the newly published Essentials of Complementary and Alternative Medicine (Lippincott, Williams & Wilkins), which he edited with Dr Wayne Jonas; and the forthcoming God, Faith, and Health (John Wiley & Sons). Alternative Therapies interviewed Dr Levin at his home in Topeka, Kan, where he lives with his wife, Dr Lea Steele Levin. PMID:10394678

  1. Effective Field Theories for Hot and Dense Matter

    NASA Astrophysics Data System (ADS)

    Blaschke, D.

    2010-10-01

    The lecture is divided in two parts. The first one deals with an introduction to the physics of hot, dense many-particle systems in quantum field theory [1, 2]. The basics of the path integral approach to the partition function are explained for the example of chiral quark models. The QCD phase diagram is discussed in the meanfield approximation while QCD bound states in the medium are treated in the rainbow-ladder approximation (Gaussian fluctuations). Special emphasis is devoted to the discussion of the Mott effect, i.e. the transition of bound states to unbound, but resonant scattering states in the continnum under the influence of compression and heating of the system. Three examples are given: (1) the QCD model phase diagram with chiral symmetry ¨ restoration and color superconductivity [3], (2) the Schrodinger equation for heavy-quarkonia [4], and (2) Pions [5] as well as Kaons and D-mesons in the finite-temperature Bethe-Salpeter equation [6]. We discuss recent applications of this quantum field theoretical approach to hot and dense quark matter for a description of anomalous J/ψ supression in heavy-ion collisions [7] and for the structure and cooling of compact stars with quark matter interiors [8]. The second part provides a detailed introduction to the Polyakov-loop Nambu-Jona-Lasinio model [9] for thermodynamics and mesonic correlations [10] in the phase diagram of quark matter. Important relationships of low-energy QCD like the Gell-Mann-Oakes-Renner relation are generalized to finite temperatures. The effect of including the coupling to the Polyakov-loop potential on the phase diagram and mesonic correlations is discussed. An outlook is given to effects of nonlocality of the interactions [11] and of mesonic correlations in the medium [12] which go beyond the meanfield description.

  2. The influence of solution composition and grain boundaries on the replacement of calcite by dolomite

    NASA Astrophysics Data System (ADS)

    Moraila Martinez, Teresita de Jesus; Putnis, Christine V.; Putnis, Andrew

    2016-04-01

    microreactors during reactive fluid flow: experimental dolomitization of a calcite marble. Contributions to Mineralogy and Petrology. 168:1045. 2. Jonas L., Müller T., Dohmen R., Baumgartner L., Putlitz B. (2015). Transport-controlled hydrothermal replacement of calcite by Mg-carbonates. Geology. doi:10.1130/G36934.1 3. Kaczmarek S.E., Sibley D.F., (2011). On the evolution of dolomite stoichiometry and cation order during high-temperature synthesis experiments: An alternative model for geochemical evolution of natural dolomites. Sedimentary Geology. 246, 30-40.

  3. Psychosomatic medicine and the philosophy of life.

    PubMed

    Schwartz, Michael A; Wiggins, Osborne P

    2010-01-01

    Basing ourselves on the writings of Hans Jonas, we offer to psychosomatic medicine a philosophy of life that surmounts the mind-body dualism which has plagued Western thought since the origins of modern science in seventeenth century Europe. Any present-day account of reality must draw upon everything we know about the living and the non-living. Since we are living beings ourselves, we know what it means to be alive from our own first-hand experience. Therefore, our philosophy of life, in addition to starting with what empirical science tells us about inorganic and organic reality, must also begin from our own direct experience of life in ourselves and in others; it can then show how the two meet in the living being. Since life is ultimately one reality, our theory must reintegrate psyche with soma such that no component of the whole is short-changed, neither the objective nor the subjective. In this essay, we lay out the foundational components of such a theory by clarifying the defining features of living beings as polarities. We describe three such polarities: 1) Being vs. non-being: Always threatened by non-being, the organism must constantly re-assert its being through its own activity. 2) World-relatedness vs. self-enclosure: Living beings are both enclosed with themselves, defined by the boundaries that separate them from their environment, while they are also ceaselessly reaching out to their environment and engaging in transactions with it. 3) Dependence vs. independence: Living beings are both dependent on the material components that constitute them at any given moment and independent of any particular groupings of these components over time.We then discuss important features of the polarities of life: Metabolism; organic structure; enclosure by a semi-permeable membrane; distinction between "self" and "other"; autonomy; neediness; teleology; sensitivity; values. Moral needs and values already arise at the most basic levels of life, even if only human

  4. Collective excitations in a superfluid of color-flavor locked quark matter

    SciTech Connect

    Fukushima, Kenji; Iida, Kei

    2005-04-01

    We investigate collective excitations coupled with baryon density in a system of massless three-flavor quarks in the collisionless regime. By using the Nambu-Jona-Lasinio (NJL) model in the mean-field approximation, we field-theoretically derive the spectra both for the normal and color-flavor locked (CFL) superfluid phases at zero temperature. In the normal phase, we obtain usual zero sound as a low-lying collective mode in the particle-hole (vector) channel. In the CFL phase, the nature of collective excitations varies in a way dependent on whether the excitation energy, {omega}, is larger or smaller than the threshold given by twice the pairing gap {delta}, at which pair excitations with nonzero total momentum become allowed to break up into two quasiparticles. For {omega}<<2{delta}, a phonon corresponding to fluctuations in the U(1) phase of {delta} appears as a sharp peak in the particle-particle ('H') channel. We reproduce the property known from low-energy effective theories that this mode propagates at a velocity of v{sub H}=1/{radical}(3) in the low momentum regime; the decay constant f{sub H} obtained in the NJL model is identical with the QCD result obtained in the mean-field approximation. We also find that, as the momentum of the phonon increases, the excitation energy goes up and asymptotically approaches {omega}=2{delta}. Above the threshold for pair excitations ({omega}>2{delta}), zero sound manifests itself in the vector channel. By locating the zero sound pole of the vector propagator in the complex energy plane, we investigate the attenuation and energy dispersion relation of zero sound. In the long wavelength limit, the phonon mode, the only low-lying excitation, has its spectral weight in the H channel alone, while the spectral function vanishes in the vector channel. This is due to nontrivial mixing between the H and vector channels in the superfluid medium. We finally extend our study to the case of nonzero temperature. We demonstrate how

  5. Temporal Variability of Methane Flares on the Cascadia Margin Imaged with Swath Bathymetric Data (Ancillary Data to Cascadia Initiative Cruise AT26-02)

    NASA Astrophysics Data System (ADS)

    Trehu, A. M.

    2013-12-01

    Livelybrooks (Un. of Oregon), undergraduates participating in summer research programs at (Elizabeth Davis, Indiana Un. and Oregon State Un. REU program in Oceanography; David Clemens-Sewall, Dartmouth College and IRIS intern), community college students and faculty (Haley Domer, Portland CC; Jonas Cervantes and Greg Mulder, Linn-Benton CC), and graduate students and scientists who had applied to sailed on a Cascadia Initiative cruise (Bridget Hass, Oregon State Un.; Katherine Kirk, Cornell Un. and WHOI; Anton Ypma, Western Washington Un.; Lexi Black, CA State Un. Northridge; Samantha Black, College of Charleston). WHOI marine technician Rob Hagg and MATE Intern Arianna Johns also contributed significantly to this effort.

  6. Local Geostatistical Models and Big Data in Hydrological and Ecological Applications

    NASA Astrophysics Data System (ADS)

    Hristopulos, Dionissios

    2015-04-01

    helps to overcome a significant computational bottleneck of geostatistical models due to the poor scaling of the matrix inversion [4,5]. We present applications to real and simulated data sets, including the Walker lake data, and we investigate the SLI performance using various statistical cross validation measures. References [1] T. Hofmann, B. Schlkopf, A.J. Smola, Annals of Statistics, 36, 1171-1220 (2008). [2] D. T. Hristopulos, SIAM Journal on Scientific Computing, 24(6): 2125-2162 (2003). [3] D. T. Hristopulos and S. N. Elogne, IEEE Transactions on Signal Processing, 57(9): 3475-3487 (2009) [4] G. Jona Lasinio, G. Mastrantonio, and A. Pollice, Statistical Methods and Applications, 22(1):97-112 (2013) [5] Sun, Y., B. Li, and M. G. Genton (2012). Geostatistics for large datasets. In: Advances and Challenges in Space-time Modelling of Natural Events, Lecture Notes in Statistics, pp. 55-77. Springer, Berlin-Heidelberg.

  7. Reader-Centered Technical Writing

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2012-12-01

    an old schema. This reinforces basic engineering and mathematical design concepts. Accommodation: Here, it may work in a different manner. Writers may have to accommodate an old schema to a new object. This helps engineers to focus more on applications. Adaptation: Assimilation and accommodation are the two sides of adaptation, Jean Piaget's term for what most of us would call learning. Mathematical design concepts generated by students should be suitable for creative engineering applications. References : Phillips, D. C. and Soltis, Jonas F. (2003) "Piagetian Structures and Psychological Constructivism," in Perspectives on Learning (4th edition). New York: Teachers College Press. Salvo, Michael J. (2001). Ethics of Engagement: User-Centered Design and Rhetorical Methodology. Technical Communication Quarterly Volume 10, Issue 3, 2001. pages 273-290. http://www.ship.edu/~cgboeree/piaget.html http://owl.english.purdue.edu/owl/resource/624/01/

  8. Instantons and chiral symmetry in string theory

    NASA Astrophysics Data System (ADS)

    Jensen, Steuard B.

    The study of non-perturbative effects has played an important role in many recent developments in physics. String theory has proven to be an especially fertile ground for such studies: not only is its own non-perturbative structure interesting, but it has emerged as a framework in which to study the strongly coupled behavior of a variety of models in quantum field theory as well. In this thesis, I present results demonstrating the use of string theory in both these ways. First, I discuss non-perturbative corrections to the Kaluza-Klein monopole in string theory. As usually described, this object has an isometry around a compact circle and is related by T-duality to a "smeared" NS5-brane which retains that isometry. The true NS5-brane solution is localized at a point on the circle, so duality implies that the Kaluza-Klein monopole should show some corresponding behavior. By expressing the Kaluza-Klein monopole as a gauged linear sigma model in two dimensions, I show that worldsheet instantons give corrections to its geometry. These corrections can be understood as a localization in "winding space" which could be probed by strings with winding charge around the circle. Second, I discuss a configuration of D-branes in string theory whose low energy physics corresponds to a 3+1-dimensional quantum field theory with dynamically broken chiral symmetry. In a weakly coupled region of parameter space, this theory is a non-local generalization of the Nambu-Jona-Lasinio model. Indications are given that this model dynamically breaks chiral symmetry at arbitrarily weak 't Hooft coupling. At strong coupling this field theory is no longer solvable directly, but an alternate weakly coupled description can be found from the string theory model: the dynamics is determined by replacing a stack of D-branes by their near-horizon geometry and studying the low energy theory on probe D-branes in that background. In yet another region of parameter space, this D-brane configuration gives

  9. Effective Field Theories of Baryons and Mesons or, what do Quarks Do?.

    NASA Astrophysics Data System (ADS)

    Keaton, Gregory Lee

    1995-01-01

    This thesis is an attempt to understand the properties of the protons, pions and other hadrons in terms of their fundamental building blocks. In the first chapter, I review several of the approaches that have already been developed. The Nambu-Jona-Lasinio model offers the classic example of a derivation of meson properties from a quark Lagrangian. The chiral quark model encodes much of the intuition acquired in recent decades. I also discuss the non-linear sigma model, the Skyrme model, and the constituent quark model, which is one of the oldest and most successful models. In the constituent quark model, the constituent quark appears to be different from the "current" quark that appears in the fundamental QCD Lagrangian. Recently it was proposed that the constituent quark is a topological soliton. In chapter 2 I investigate this soliton, calculating its mass, radius, magnetic moment, color magnetic moment, and spin structure function. Within the approximations used, the magnetic moments and spin structure function cannot simultaneously be made to agree with the constituent quark model. Some discussion of what to expect from better approximations is included. In Chapter 3 I use a different plan of attack. Rather than trying to model the constituents of the baryon, I begin with an effective field theory of baryons and mesons, with couplings and masses that are simply determined phenomenologically. Meson loop corrections to baryon axial currents are then computed in the 1/N expansion. It is already known that the one -loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by 1/N^2. To leading order, these corrections are exactly the same as would be calculated in the constituent quark model. This method therefore offers a different approach to the constituent quark. The appendices give some calculational details omitted in the text, including the strange fractal-like behaviour encountered while integrating some

  10. Missed connections: A case study of the social networks of physics doctoral students in a single department

    NASA Astrophysics Data System (ADS)

    Knaub, Alexis Victoria

    research decreases the time to degree. Only research peer network and departmental information network variables remain in this model. Suggestions for further research for both physics/STEM education and social network analysis are included. Suggestions for ways in which the Jonas University physics department can improve its climate are also included. Although these suggestions are written based upon the Jonas University data, they may be applicable to other physics/STEM graduate programs.

  11. 2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.

    PubMed

    2012-04-01

    Third Edition [Formula: see text] [Box: see text] Printed with permission from the International Society for Biological and Environmental Repositories (ISBER) © 2011 ISBER All Rights Reserved Editor-in-Chief Lori D. Campbell, PhD Associate Editors Fay Betsou, PhD Debra Leiolani Garcia, MPA Judith G. Giri, PhD Karen E. Pitt, PhD Rebecca S. Pugh, MS Katherine C. Sexton, MBA Amy P.N. Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use. Sharing successful strategies for accomplishing this goal is one of the driving forces for the International Society for Biological and Environmental Repositories (ISBER). For more information about ISBER see www.isber.org . ISBER's Best Practices for Repositories (Best Practices) reflect the collective experience of its members and has received broad input from other repository professionals. Throughout this document

  12. Reconstruction of 3d grain boundaries from rock thin sections, using polarised light

    NASA Astrophysics Data System (ADS)

    Markus Hammes, Daniel; Peternell, Mark

    2016-04-01

    Grain boundaries affect the physical and chemical properties of polycrystalline materials significantly by initiating reactions and collecting impurities (Birchenall, 1959), and play an essential role in recrystallization (Doherty et al. 1997). In particular, the shape and crystallographic orientation of grain boundaries reveal the deformation and annealing history of rocks (Kruhl and Peternell 2002, Kuntcheva et al. 2006). However, there is a lack of non-destructive and easy-to-use computer supported methods to determine grain boundary geometries in 3D. The only available instrument using optical light to measure grain boundary angles is still the polarising microscope with attached universal stage; operated manually and time-consuming in use. Here we present a new approach to determine 3d grain boundary orientations from 2D rock thin sections. The data is recorded by using an automatic fabric analyser microscope (Peternell et al., 2010). Due to its unique arrangement of 9 light directions the highest birefringence colour due to each light direction and crystal orientation (retardation) can be determined at each pixel in the field of view. Retardation profiles across grain boundaries enable the calculation of grain boundary angle and direction. The data for all positions separating the grains are combined and further processed. In combination with the lateral position of the grain boundary, acquired using the FAME software (Hammes and Peternell, in review), the data is used to reconstruct a 3d grain boundary model. The processing of data is almost fully automatic by using MATLAB®. Only minor manual input is required. The applicability was demonstrated on quartzite samples, but the method is not solely restricted on quartz grains and other birefringent polycrystalline materials could be used instead. References: Birchenall, C.E., 1959: Physical Metallurgy. McGraw-Hill, New York. Doherty, R.D., Hughes, D.A., Humphreys, F.J., Jonas, J.J., Juul Jensen, D., Kassner, M

  13. Communicating climate change: alerting versus stimulating action, a few "philosophical" interrogations from a marine biogeochemist

    NASA Astrophysics Data System (ADS)

    Ragueneau, O.

    2009-04-01

    can come to calculate their own emissions and then, replace them in a more global context. During the debates then, very rapidly, politics and ethics come into play. Beyond the question raised above concerning outreach versus engagement, I find it VERY DIFFICULT to find the right balance between alerting and stimulating action. On one hand, we need to alert on the reality of the numbers given (and it is hard to reduce our personal emissions by a factor of 4 in France or 10 in the US), the ethical problems they raise (we, in developed countries, are responsible for the majority of past CO2 emissions and we should do the major effort, Ragueneau et al., 2008). And on the other hand, we need to remain optimistic and show that solutions do exist, if we do not want to discourage people to act. There is debate between the ethics of fear (H. Jonas) and the ethics of hope (E. Morin) as best ways to stimulate action and I feel we need to share our experiences on how best navigate between these two lines. So I would be very happy to participate in such a session to discuss the role of scientists in essential issues such as societal debates related to climate change, the frontier between outreach and political engagement, and the attitude needed to convince that there is a problem, that this problem is big and we need to stress it, but that it can be addressed with very positive implications for each of us.

  14. EDITORIAL: Focus on Nanostructured Soft Matter

    NASA Astrophysics Data System (ADS)

    Reineker, Peter; Schülz, Michael

    2004-01-01

    Nanostructures in general are playing a more and more important role in the physics and chemistry of condensed matter systems including both hard and soft materials. This Focus Issue concentrates particularly on recent developments in Nanostructured Soft Matter Systems. Many interesting questions related to both fundamental and applied research in this field have arisen. Some of them are connected to the chemical reactions that take place during the irreversible formation of soft matter systems. Others refer to the theoretical and experimental investigations of structures and topologies of `nanostructured soft matter', e.g. heterogeneous polymers and polymer networks, or soft matter at low dimensions or in constrained geometries. Additional research has also been devoted to the dynamics of other complex nanostructured systems, such as the structure formation on the basis of polymer systems and polyelectrolytes, and several kinds of phase transitions on nano- and microscales. The contributions collected here present the most up-to-date research results on all of these topics. New Journal of Physics, as an electronic journal, is perfectly suited for the presentation of the complex results that the experimental and theoretical investigations reported here yield. The articles that will follow provide a number of excellent examples of the use of animations, movies and colour features for the added benefit of the reader. Focus on Nanostructured Soft Matter Contents Phase separation kinetics in compressible polymer solutions: computer simulation of the early stages Peter Virnau, Marcus Müller, Luis González MacDowell and Kurt Binder Spectral dynamics in the B800 band of LH2 from Rhodospirillum molischianum: a single-molecule study Clemens Hofmann, Thijs J Aartsma, Hartmut Michel and Jürgen Köhler Adsorption of polyacrylic acid on self-assembled monolayers investigated by single-molecule force spectroscopy Claudia Friedsam, Aránzazu Del Campo Bécares, Ulrich Jonas

  15. Annotated type catalogue of the Bulimulidae (Mollusca, Gastropoda, Orthalicoidea) in the Natural History Museum, London

    PubMed Central

    Breure, Abraham S.H.; Ablett, Jonathan D.

    2014-01-01

    , 1909; Bulimus (Otostomus) napo Angas, 1878; Drymaeus notabilis da Costa, 1906; Drymaeus notatus da Costa, 1906; Bulimulus (Drymaeus) nubilus Preston, 1903; Drymaeus obliquistriatus da Costa, 1901; Bulimus (Drymaeus) ochrocheilus E.A. Smith, 1877; Bulimus (Drymaeus) orthostoma E.A. Smith, 1877; Drymaeus expansus perenensis da Costa, 1901; Bulimulus pergracilis Rolle, 1904; Bulimulus (Drymaeus) plicatoliratus da Costa, 1898; Drymaeus prestoni da Costa, 1906; Drymaeus punctatus da Costa, 1907; Bulimus (Leptomerus) sanctaeluciae E.A. Smith, 1889; Bulimulus (Drymaeus) selli Preston, 1909; Drymaeus subventricosus da Costa, 1901; Bulimulus (Drymaeus) tigrinus da Costa, 1898; Drymaeus volsus Fulton, 1907; Drymaeus wintlei Finch, 1929; Bulimus zhorquinensis Angas, 1879; Bulimulus (Drymaeus) ziczac da Costa, 1898. The following junior subjective synonyms are established: Bulimus antioquensis Pfeiffer, 1855 = Bulimus baranguillanus Pfeiffer, 1853; Drymaeus bellus da Costa, 1906 = Drymaeus blandi Pilsbry, 1897; Bulimus hachensis Reeve 1850 = Bulimus gruneri Pfeiffer, 1846 = Bulimus columbianus Lea, 1838; Bulimus (Otostomus) lamas Higgins 1868 = Bulimus trujillensis Philippi, 1867; Bulimulus (Drymaeus) binominis lascellianus E.A. Smith, 1895 = Bulimulus (Drymaeus) binominis E.A. Smith, 1895; Drymaeus multispira da Costa, 1904 = Helix torallyi d’Orbigny, 1835; Bulimulus (Drymaeus) plicatoliratus Da Costa, 1898 = Bulimus convexus Pfeiffer, 1855; Bulimus sugillatus Pfeiffer, 1857 = Bulimus rivasii d’Orbigny, 1837; Bulimus meridionalis Reeve 1848 [June] = Bulimus voithianus Pfeiffer, 1847. New combinations are: Bostryx montagnei (d’Orbigny, 1837); Bostryx obliquiportus (da Costa, 1901); Bulimulus heloicus (d’Orbigny, 1835); Drymaeus (Drymaeus) lusorius (Pfeiffer, 1855); Drymaeus (Drymaeus) trigonostomus (Jonas, 1844); Drymaeus (Drymaeus) wintlei Finch, 1929; Drymaeus (Mesembrinus) conicus da Costa, 1907; Kuschelenia (Kuschelenia) culminea culminea (d’Orbigny, 1835); Kusche

  16. Geology and ground-water resources of Washington, D.C., and vicinity

    USGS Publications Warehouse

    Johnston, Paul McKelvey

    1964-01-01

    The area of this report includes 436 square miles centered about the District of Columbia. The area contains parts of two distinctly different physiographic provinces-the Piedmont and the Coastal Plain. The Fall Line, which separates the Piedmont province on the west from the Coastal Plain Province on the east, bisects the area diagonally from northeast to southwest. Northwest of the Fall Line, deeply weathered igneous and metamorphic rocks are exposed ; to the southeast, these rocks are covered by Coastal Plain sediments; the nonconformity between crystalline rock and sediments dips southeast at an average rate of about 125 feet per mile. The rocks of the Piedmont include: (1) schist, phyllite, and quartzite of the Wissahickon Formation; (2) altered mafic rocks such as greenstone and serpentine; (3) the Laurel Gneiss of Chapman, 1942, and the Sykesville Formation of Jonas, 1928--both probably derived from the Wissahickon ; and (4) later granitic intrusive rocks. Lying upon this basement of hard rocks east of the Fall Line are the generally unconsolidated sediments of the Coastal Plain, which include gravel, sand, and clay, ranging in age from Cretaceous to Recent. These sediments measure only a few inches at their western extremity but thicken to 1,800 feet at the southeast corner of the mapped area. Owing to the great diversity in the geology of the two provinces, the waterbearing characteristics of the rocks also vary greatly. In the Piedmont, ground water occurs under unconfined or water-table conditions in openings and fissures in the hard rocks or in the residual weathered blanket that overlies them. In the Coastal Plain, the shallow wells tap unconfined water, but beneath the upper clay layers the water is contained in the sand and gravel under artesian pressure and must be recovered by deep drilled wells. Wells are of three types--drilled, bored, and dug. Drilled wells furnish a permanent water supply and are the least subject to pollution when properly

  17. Annotated type catalogue of the Bulimulidae (Mollusca, Gastropoda, Orthalicoidea) in the Natural History Museum, London

    PubMed Central

    Breure, Abraham S.H.; Ablett, Jonathan D.

    2014-01-01

    , 1909; Bulimus (Otostomus) napo Angas, 1878; Drymaeus notabilis da Costa, 1906; Drymaeus notatus da Costa, 1906; Bulimulus (Drymaeus) nubilus Preston, 1903; Drymaeus obliquistriatus da Costa, 1901; Bulimus (Drymaeus) ochrocheilus E.A. Smith, 1877; Bulimus (Drymaeus) orthostoma E.A. Smith, 1877; Drymaeus expansus perenensis da Costa, 1901; Bulimulus pergracilis Rolle, 1904; Bulimulus (Drymaeus) plicatoliratus da Costa, 1898; Drymaeus prestoni da Costa, 1906; Drymaeus punctatus da Costa, 1907; Bulimus (Leptomerus) sanctaeluciae E.A. Smith, 1889; Bulimulus (Drymaeus) selli Preston, 1909; Drymaeus subventricosus da Costa, 1901; Bulimulus (Drymaeus) tigrinus da Costa, 1898; Drymaeus volsus Fulton, 1907; Drymaeus wintlei Finch, 1929; Bulimus zhorquinensis Angas, 1879; Bulimulus (Drymaeus) ziczac da Costa, 1898. The following junior subjective synonyms are established: Bulimus antioquensis Pfeiffer, 1855 = Bulimus baranguillanus Pfeiffer, 1853; Drymaeus bellus da Costa, 1906 = Drymaeus blandi Pilsbry, 1897; Bulimus hachensis Reeve 1850 = Bulimus gruneri Pfeiffer, 1846 = Bulimus columbianus Lea, 1838; Bulimus (Otostomus) lamas Higgins 1868 = Bulimus trujillensis Philippi, 1867; Bulimulus (Drymaeus) binominis lascellianus E.A. Smith, 1895 = Bulimulus (Drymaeus) binominis E.A. Smith, 1895; Drymaeus multispira da Costa, 1904 = Helix torallyi d’Orbigny, 1835; Bulimulus (Drymaeus) plicatoliratus Da Costa, 1898 = Bulimus convexus Pfeiffer, 1855; Bulimus sugillatus Pfeiffer, 1857 = Bulimus rivasii d’Orbigny, 1837; Bulimus meridionalis Reeve 1848 [June] = Bulimus voithianus Pfeiffer, 1847. New combinations are: Bostryx montagnei (d’Orbigny, 1837); Bostryx obliquiportus (da Costa, 1901); Bulimulus heloicus (d’Orbigny, 1835); Drymaeus (Drymaeus) lusorius (Pfeiffer, 1855); Drymaeus (Drymaeus) trigonostomus (Jonas, 1844); Drymaeus (Drymaeus) wintlei Finch, 1929; Drymaeus (Mesembrinus) conicus da Costa, 1907; Kuschelenia (Kuschelenia) culminea culminea (d’Orbigny, 1835

  18. Strong Coupling Gauge Theories in LHC ERA

    NASA Astrophysics Data System (ADS)

    Fukaya, H.; Harada, M.; Tanabashi, M.; Yamawaki, K.

    2011-01-01

    Higgs, or techni-dilaton - composite Higgs near conformality / Koichi Yamawaki -- Phase diagram of strongly interacting theories / Francesco Sannino -- Resizing conformal windows / O. Antipin and K. Tuominen -- Nearly conformal gauge theories on the lattice / Zoltan Fodor ... [et al.] -- Going beyond QCD in lattice gauge theory / G. T. Fleming -- Phases of QCD from small to large N[symbol]: (some) lattice results / A. Deuzeman, E. Pallante and M. P. Lombardo -- Lattice gauge theory and (quasi)-conformal technicolor / D. K. Sinclair and J. B. Kogut -- Study of the running coupling constant in 10-flavor QCD with the Schrodinger functional method / N. Yamada ... [et al.] -- Study of the running coupling in twisted Polyakov scheme / T. Aoyama ... [et al.].Running coupling in strong gauge theories via the lattice / Zoltan Fodor ... [et al.] -- Higgsinoless supersymmetry and hidden gravity / Michael L. Graesser, Ryuichiro Kitano and Masafumi Kurachi -- The latest status of LHC and the EWSB physics / S. Asai -- Continuum superpartners from supersymmetric unparticles / Hsin-Chia Cheng -- Review of minimal flavor constraints for technicolor / Hidenori S. Fukano and Francesco Sannino -- Standard model and high energy Lorentz violation / Damiano Anselmi -- Dynamical electroweak symmetry breaking and fourth family / Michio Hashimoto -- Holmorphic supersymmetric Nambu-Jona-Lasino model and dynamical electroweak symmetry breaking / Dong-Won Jung, Otto C. W. Kong and Jae Sik Lee -- Ratchet model of Baryogenesis / Tatsu Takeuchi, Azusa Minamizaki and Akio Sugamoto -- Classical solutions of field equations in Einstein Gauss-Bonnet gravity / P. Suranyi, C. Vaz and L. C. R. Wijewardhana -- Black holes constitute all dark matter / Paul H. Frampton -- Electroweak precision test and Z [symbol] in the three site Higgsless model / Tomohiro Abe -- Chiral symmetry and BRST symmetry breaking, quaternion reality and the lattice simulation / Sadataka Furui -- Holographic techni-dilaton, or

  19. From quarks to cold atoms: The phases of strongly-interacting systems

    NASA Astrophysics Data System (ADS)

    Powell, Philip D.

    In this thesis we investigate the phase structure of dense quark matter, the structure and stability of neutron and quark stars, and the phases of ultracold fermions in the presence of an artificial spin-orbit coupling. While spanning an extraordinary twenty orders of magnitude in energy scales, these systems exhibit some remarkable similarities including non-perturbative many-body interactions, perfect fluid behavior, the formation of Cooper pairs, and the possibility of BCS-BEC crossovers between weakly and strongly interacting regimes. Moreover, due to phenomenal advancements in laser cooling techniques and the ability to exert an unprecedented level of control over the interactions of ultracold atomic gases, the possibility of using these systems to simulate the complex behavior of systems not easily realized in the laboratory (e.g., non-Abelian gauge fields, quantum chromodynamics) is becoming increasingly real. Despite the widespread success of quantum chromodynamics (QCD), the theory of the strong nuclear force, much remains unknown about the properties of strongly-interacting quark matter. In large part, this continued ignorance is a result of the mathematical intractability of QCD and the limitations of current numerical techniques to very low densities. In the first part of this thesis, in order to gain some insight into the phase structure of dense quark matter we therefore apply an effective field theory which is built upon the symmetries of QCD, the Polyakov--Nambu--Jona-Lasinio (PNJL) model. We construct the QCD phase diagram for two and three quark flavors, giving special attention to the effect of the intermediate strange quark mass on the preferred quark pairing structure at intermediate to high density. In addition, we investigate the impact of the strange quark mass and axial anomaly on a recently proposed low temperature critical point, which may allow for a smooth crossover between hadronic and color superconducting matter. Finally, we

  20. EDITORIAL: Focus on Quantum Correlations in Tailored Matter

    NASA Astrophysics Data System (ADS)

    Muramatsu, Alejandro; Pfau, Tilman

    2008-04-01

    molecules L Wang, A Rastelli, S Kiravittaya, P Atkinson, F Ding, C C Bof Bufon, C Hermannstädter, M Witzany, G J Beirne, P Michler and O G Schmidt Effective parameters for weakly coupled Bose-Einstein condensates S Giovanazzi, J Esteve and M K Oberthaler Current statistics of correlated charge tunnelling through an impurity in a 1D wire Alexander Herzog and Ulrich Weiss Sideband cooling and coherent dynamics in a microchip multi-segmented ion trap Stephan A Schulz, Ulrich Poschinger, Frank Ziesel and Ferdinand Schmidt-Kaler The trapped two-dimensional Bose gas: from Bose-Einstein condensation to Berezinskii-Kosterlitz-Thouless physics Z Hadzibabic, P Krüger, M Cheneau, S P Rath and J Dalibard Dynamical protection of quantum computation from decoherence in laser-driven cold-ion and cold-atom systems Goren Gordon and Gershon Kurizki Spin-flip and spin-conserving optical transitions of the nitrogen-vacancy centre in diamond Ph Tamarat, N B Manson, J P Harrison, R L McMurtrie, A Nizovtsev, C Santori, R G Beausoleil, P Neumann, T Gaebel, F Jelezko, P Hemmer and J Wrachtrup Superconductivity in the attractive Hubbard model: functional renormalization group analysis R Gersch, C Honerkamp and W Metzner Quantum stability of Mott-insulator states of ultracold atoms in optical resonators Jonas Larson, Sonia Fernández-Vidal, Giovanna Morigi and Maciej Lewenstein

  1. Exotic States of Nuclear Matter

    NASA Astrophysics Data System (ADS)

    Lombardo, Umberto; Baldo, Marcello; Burgio, Fiorella; Schulze, Hans-Josef

    2008-02-01

    . Pairing in BCS theory and beyond / L. G. Cao, U. Lombardo & P. Schuck. Pinning and binding energies for vortices in neutron stars: comments on recent results / P. M. Pizzochero. Structure of a vortex in the inner crust of neutron stars / P. Avogadro ... [et al.]. The dynamics of vortex pinning in the neutron star crust / B. Link -- pt. H. Poster session. Microscopic data and supernovae evolution / P. Blottiau, Ph. Mellor & J. Margueron. Parity doublet model applied to neutron star / V. Dexheimer, S. Schramm & H. Stoecker. Structure of hybrid stars / D. Jaccarino, U. Lombardo & G. X. Peng. Nuclear three-body force from the Nijmegen potential / Z. H. Li ... [et al.]. Monopole excitations in QRPA on top of HFB / J. Li, G. Colò & J. Meng. The influence of the [symbol]-field on neutron stars / A. J. Mi, W. Zuo & A. Li. Magnetization of color-flavor locked matter / J. Noronha & I. A. Shovkovy. Ab initio pairing gap calculation for a slab of nuclear matter with Paris and Argonne V18 bare NN-potentials / S. S. Pankratov et al. Hybrid neutron stars within the Nambu-Jona-Lasinio model and confinement / S. Plumari et al. A study of pairing interaction in a separable form / Y. Tian, Z. Ma & P. Ring. Isospin dependence of nuclear matter / E. N. E Van Dalen ... [et al.]. Ejected elements from the envelope of compact stars by QCD phase transition / N. Yasutake et al. Microscopic three-body force effect on nucleon-nucleon cross sections / H. F. Zhang et al. Tensor correlations and single-particle states in medium-mass nuclei / W. Zou et al.

  2. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    NASA Astrophysics Data System (ADS)

    Suominen, Kalle-Antti

    2010-09-01

    information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

  3. EDITORIAL: Van der Waals interactions in advanced materials, in memory of David C Langreth Van der Waals interactions in advanced materials, in memory of David C Langreth

    NASA Astrophysics Data System (ADS)

    Hyldgaard, Per; Rahman, Talat S.

    2012-10-01

    Rahman Frictional temperature rise in a sliding physisorbed monolayer of Kr/grapheneM Walker, C Jaye, J Krim and Milton W Cole How to modify the van der Waals and Casimir forces without change of the dielectric permittivityG L Klimchitskaya, U Mohideen and V M Mostepanenko Spectroscopic characterization of van der Waals interactions in a metal organic framework with unsaturated metal centers: MOF-74-MgNour Nijem, Pieremanuele Canepa, Lingzhu Kong, Haohan Wu, Jing Li, Timo Thonhauser and Yves J Chabal A theoretical study of the hydrogen-storage potential of (H2)4CH4 in metal organic framework materials and carbon nanotubesQ Li and T Thonhauser The influence of dispersion interactions on the hydrogen adsorption properties of expanded graphiteYungok Ihm, Valentino R Cooper, Lujian Peng and James R Morris A DFT-D study of structural and energetic properties of TiO2 modificationsJonas Moellmann, Stephan Ehrlich, Ralf Tonner and Stefan Grimme Spherical-shell model for the van der Waals coefficients between fullerenes and/or nearly spherical nanoclustersJohn P Perdew, Jianmin Tao, Pan Hao, Adrienn Ruzsinszky, Gábor I Csonka and J M Pitarke Dynamical screening of the van der Waals interaction between graphene layersY J Dappe, P G Bolcatto, J Ortega and F Flores Structural evolution of amino acid crystals under stress from a non-empirical density functionalRiccardo Sabatini, Emine Küçükbenli, Brian Kolb, T Thonhauser and Stefano de Gironcoli Physisorption of nucleobases on graphene: a comparative van der Waals studyDuy Le, Abdelkader Kara, Elsebeth Schröder, Per Hyldgaard and Talat S Rahman The role of van der Waals interactions in the adsorption of noble gases on metal surfacesDe-Li Chen, W A Al-Saidi and J Karl Johnson Desorption of n-alkanes from graphene: a van der Waals density functional studyElisa Londero, Emma K Karlson, Marcus Landahl, Dimitri Ostrovskii, Jonatan D Rydberg and Elsebeth Schröder Benchmarking van der Waals density functionals with experimental data