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Sample records for jonas vilys vytautas

  1. Driving pressure and mechanical power: new targets for VILI prevention.

    PubMed

    Tonetti, Tommaso; Vasques, Francesco; Rapetti, Francesca; Maiolo, Giorgia; Collino, Francesca; Romitti, Federica; Camporota, Luigi; Cressoni, Massimo; Cadringher, Paolo; Quintel, Michael; Gattinoni, Luciano

    2017-07-01

    Several factors have been recognized as possible triggers of ventilator-induced lung injury (VILI). The first is pressure (thus the 'barotrauma'), then the volume (hence the 'volutrauma'), finally the cyclic opening-closing of the lung units ('atelectrauma'). Less attention has been paid to the respiratory rate and the flow, although both theoretical considerations and experimental evidence attribute them a significant role in the generation of VILI. The initial injury to the lung parenchyma is necessarily mechanical and it could manifest as an unphysiological distortion of the extracellular matrix and/or as micro-fractures in the hyaluronan, likely the most fragile polymer embedded in the matrix. The order of magnitude of the energy required to break a molecular bond between the hyaluronan and the associated protein is 1.12×10(-16) Joules (J), 70-90% higher than the average energy delivered by a single breath of 1L assuming a lung elastance of 10 cmH2O/L (0.5 J). With a normal statistical distribution of the bond strength some polymers will be exposed each cycle to an energy large enough to rupture. Both the extracellular matrix distortion and the polymer fractures lead to inflammatory increase of capillary permeability with edema if a pulmonary blood flow is sufficient. The mediation analysis of higher vs. lower tidal volume and PEEP studies suggests that the driving pressure, more than tidal volume, is the best predictor of VILI, as inferred by increased mortality. This is not surprising, as both tidal volume and respiratory system elastance (resulting in driving pressure) may independently contribute to the mortality. For the same elastance driving pressure is a predictor similar to plateau pressure or tidal volume. Driving pressure is one of the components of the mechanical power, which also includes respiratory rate, flow and PEEP. Finding the threshold for mechanical power would greatly simplify assessment and prevention of VILI.

  2. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Kollisch-Singule, Michaela; Andrews, Penny L; Aiash, Hani; Habashi, Nader M; Gatto, Louis A

    2017-04-06

    The acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation. However, mechanical ventilation can be a double edge sword, if set improperly can exacerbate the tissue damage caused by ARDS and is known as ventilator induced lung injury (VILI). In order to minimize VILI we must understand the pathophysiologic mechanisms of tissue damage at the alveolar level. In this Physiology in Medicine paper the dynamic physiology of alveolar inflation and deflation during mechanical ventilation will be reviewed. In addition, the pathophysiologic mechanisms of VILI will be reviewed and this knowledge used to suggest an optimal mechanical breath profile (MBP - all airway pressures, volumes, flows, rates and the duration that they are applied at both inspiration and expiration) necessary to minimize VILI. Our review suggests that the current protective ventilation strategy known as the 'Open Lung Strategy' would be the optimal lung protective approach. However, the viscoelastic behavior of dynamic alveolar inflation and deflation has not yet been incorporated into protective mechanical ventilation strategies. Using our knowledge of dynamic alveolar mechanics (i.e the dynamic change in alveolar and alveolar duct size and shape during tidal ventilation) to modify the MBP necessary to minimize VILI will reduce the morbidity and mortality associated with ARDS.

  3. [Hans Jonas: Nature Conservation, Conservation of Life].

    PubMed

    Burgui Burgui, Mario

    2015-01-01

    This article discusses three of the problems that the German philosopher Hans Jonas studied. The first one addresses the need for a specific ethic dedicated to the moral dimension of environmental problems, from a different perspective to the traditional. The second problem is crucial in the discussion on environmental ethics: the value of the nature. Does the nature have an intrinsic value or an instrumental value only (to satisfy the interests of the human being)? The thesis of Jonas, which claimed that nature is a good in itself, were further elaborated here. And the third problem is the derivation of moral norms and the role of man in this ethic that recognizes a good in itself in nature. According to Jonas, the human being is not diminished by recognizing the intrinsic value of nature, since the man's uniqueness and value are unquestionable. From these three central issues, the paper highlights the importance of seeking the links between bioethics and environmental ethics to address the current environmental, social and economic crisis.

  4. Determinants of Cervical Cancer Screening Accuracy for Visual Inspection with Acetic Acid (VIA) and Lugol’s Iodine (VILI) Performed by Nurse and Physician

    PubMed Central

    Raifu, Amidu O.; El-Zein, Mariam; Sangwa-Lugoma, Ghislain; Ramanakumar, Agnihotram; Walter, Stephen D.

    2017-01-01

    Background Visual inspection with acetic acid (VIA) and Lugol’s iodine (VILI) are used to screen women for cervical cancer in low-resource settings. Little is known about correlates of their diagnostic accuracy by healthcare provider. We examined determinants of VIA and VILI screening accuracy by examiner in a cross-sectional screening study of 1528 women aged 30 years or older in a suburb of Kinshasa, Democratic Republic of Congo. Methods We used a logistic regression model for sensitivity and specificity to estimate the diagnostic accuracy of VIA and VILI, independently performed by nurse and physician, as a function of sociodemographic and reproductive health characteristics. Results Nurses rated tests as positive more often than physicians (36.3% vs 30.2% for VIA, 26.2% vs 25.2% for VILI). Women’s age was the most important determinant of performance. It was inversely associated with sensitivity (nurse’s VIA: p<0.001, nurse’s VILI: p = 0.018, physician’s VIA: p = 0.005, physician’s VILI: p = 0.006) but positively associated with specificity (all four combinations: p<0.001). Increasing parity adversely affected sensitivity and specificity, but the effects on sensitivity were significant for nurses only. The screening performance of physician’s assessment was significantly better than the nurse’s (difference in sensitivity: VIA = 13%, VILI = 16%; difference in specificity: VIA = 6%, VILI = 1%). Conclusions Age and parity influence the performance of visual tests for cervical cancer screening. Proper training of local healthcare providers in the conduct of these tests should take into account these factors for improved performance of VIA and VILI in detecting cervical precancerous lesions among women in limited-resource settings. PMID:28107486

  5. Determinants of Cervical Cancer Screening Accuracy for Visual Inspection with Acetic Acid (VIA) and Lugol's Iodine (VILI) Performed by Nurse and Physician.

    PubMed

    Raifu, Amidu O; El-Zein, Mariam; Sangwa-Lugoma, Ghislain; Ramanakumar, Agnihotram; Walter, Stephen D; Franco, Eduardo L

    2017-01-01

    Visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) are used to screen women for cervical cancer in low-resource settings. Little is known about correlates of their diagnostic accuracy by healthcare provider. We examined determinants of VIA and VILI screening accuracy by examiner in a cross-sectional screening study of 1528 women aged 30 years or older in a suburb of Kinshasa, Democratic Republic of Congo. We used a logistic regression model for sensitivity and specificity to estimate the diagnostic accuracy of VIA and VILI, independently performed by nurse and physician, as a function of sociodemographic and reproductive health characteristics. Nurses rated tests as positive more often than physicians (36.3% vs 30.2% for VIA, 26.2% vs 25.2% for VILI). Women's age was the most important determinant of performance. It was inversely associated with sensitivity (nurse's VIA: p<0.001, nurse's VILI: p = 0.018, physician's VIA: p = 0.005, physician's VILI: p = 0.006) but positively associated with specificity (all four combinations: p<0.001). Increasing parity adversely affected sensitivity and specificity, but the effects on sensitivity were significant for nurses only. The screening performance of physician's assessment was significantly better than the nurse's (difference in sensitivity: VIA = 13%, VILI = 16%; difference in specificity: VIA = 6%, VILI = 1%). Age and parity influence the performance of visual tests for cervical cancer screening. Proper training of local healthcare providers in the conduct of these tests should take into account these factors for improved performance of VIA and VILI in detecting cervical precancerous lesions among women in limited-resource settings.

  6. Nambu-Jona-Lasinio theory and dynamical breaking of supersymmetry

    NASA Astrophysics Data System (ADS)

    Maru, Nobuhito

    2016-06-01

    A recently proposed new mechanism of D-term-triggered dynamical supersymmetry breaking is reviewed. Supersymmetry is dynamically broken by a nonvanishing D-term vacuum expectation value, which is realized as a nontrivial solution of the gap equation in the self-consistent approximation, as in the case of the Nambu-Jona-Lasinio model and BCS superconductivity.

  7. Use of Jonas Silicon-Silver prosthesis in erectile impotence.

    PubMed

    Rowe, P H; Royle, M G

    1983-12-01

    Eleven patients presenting over the last three years with erectile impotence who have been treated by the insertion of the Jonas Silicon-Silver penile prosthesis are reviewed. The insertion of this prosthesis is a minor procedure. It has a simple design, low cost, no permanent erection or mechanical problems and an excellent cosmetic and functional result.

  8. VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region: a health economic evaluation.

    PubMed

    Xie, Yu; Tan, Xiaodong; Shao, Haiyan; Liu, Qing; Tou, Jiyu; Zhang, Yuling; Luo, Qiong; Xiang, Qunying

    2017-01-25

    Screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. To investigate the most suitable method for low-income areas in China, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and Lugol's iodine (VIA/VILI), ThinPrep cytology test (TCT), and human papillomavirus (HPV) test. We recruited 3086 women aged 35-65 years using cluster random sampling. Each participant was randomly assigned to one of three cervical cancer screening groups: VIA/VILI, TCT, or HPV test. In order to calculate the number of disability-adjusted life years (DALYs) averted by each screening method, we used Markov models to estimate the natural development of cervical cancer over a 15-year period to estimate the age of onset and duration of each disease stage. The cost-effectiveness ratios (CERs), net present values (NPVs), benefit-cost ratios (BCRs), and cost-utility ratios (CURs) were used as outcomes in the health economic analysis. The positive detection rate in the VIA/VILI group was 1.39%, which was 4.6 and 2.0 times higher than the rates in the TCT and HPV test groups, respectively. The positive predictive value of VIA/VILI (10.53%) was highest while the rate of referral for colposcopy was lowest for those in the HPV + TCT group (0.60%). VIA/VILI performed the best in terms of health economic evaluation results, as the cost of per positive case detected was 8467.9 RMB, which was 24503.0 RMB lower than that for TCT and 5755.9 RMB lower than that for the HPV test. In addition, the NPV and BCR values were 258011.5 RMB and 3.18 (the highest), and the CUR was 2341.8 RMB (the lowest). The TCT performed the worst, since its NPV was <0 and the BCR was <1, indicative of being poorly cost-beneficial. With the best economic evaluation results and requiring minimum medical resources, VIA/VILI is recommended for cervical cancer screening in poverty-stricken areas

  9. Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Andrews, Penny; Habashi, Nader M; Gatto, Louis A

    2016-12-01

    It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is a critical need to develop novel ventilation strategies that will protect the lung and reduce ARDS mortality. Protti et al. have begun to analyze the impact of mechanical ventilation on lung tissue using engineering methods in normal pigs ventilated for 54 h. They used these methods to assess the impact of a mechanical breath on dynamic and static global lung strain and energy load. Strain is the change in lung volume in response to an applied stress (i.e., Tidal Volume-Vt). This study has yielded a number of exciting new concepts including the following: (1) Individual mechanical breath parameters (e.g., Vt or Plateau Pressure) are not directly correlated with VILI but rather any combination of parameters that subject the lung to excessive dynamic strain and energy/power load will cause VILI; (2) all strain is not equal; dynamic strain resulting in a dynamic energy load (i.e., kinetic energy) is more damaging to lung tissue than static strain and energy load (i.e., potential energy); and (3) a critical consideration is not just the size of the Vt but the size of the lung that is being ventilated by this Vt. This key concept merits attention since our current protective ventilation strategies are fixated on the priority of keeping the Vt low. If the lung is fully inflated, a large Vt is not necessarily injurious. In conclusion, using engineering concepts to analyze the impact of the mechanical breath on the lung is a novel new approach to investigate VILI mechanisms and to help design the optimally protective breath. Data generated using these methods have challenged some of the current dogma surrounding the mechanisms of VILI and of the components in the mechanical breath necessary for lung protection.

  10. Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology.

    PubMed

    Longatto-Filho, Adhemar; Naud, Paulo; Derchain, Sophie Fm; Roteli-Martins, Cecília; Tatti, Sílvio; Hammes, Luciano Serpa; Sarian, Luis Otavio; Eržen, Mojca; Branca, Margherita; de Matos, Jean Carlos; Gontijo, Renata; Maeda, Marina Y S; Lima, Temístocles; Costa, Silvano; Syrjänen, Stina; Syrjänen, Kari

    2012-06-01

    We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs.

  11. Intersecting branes and Nambu-Jona-Lasinio model

    SciTech Connect

    Dhar, Avinash; Nag, Partha

    2009-06-15

    We discuss chiral symmetry breaking in the intersecting brane model of Sakai and Sugimoto at weak coupling for a generic value of separation L between the flavor D8 and anti-D8-branes. For any finite value of the radius R of the circle around which the color D4-branes wrap, a nonlocal Nambu-Jona-Lasinio-type short-range interaction couples the flavor branes and antibranes. We argue that chiral symmetry is broken in this model only above a certain critical value of the four-dimensional 't Hooft coupling and confirm this through numerical calculations of solutions to the gap equation. We also numerically investigate chiral symmetry breaking in the limit R{yields}{infinity} keeping L fixed, but find that simple ways of implementing this limit do not lead to a consistent picture of chiral symmetry breaking in the noncompact version of the nonlocal Nambu-Jona-Lasinio model.

  12. Polyakov-Nambu-Jona-Lasinio model in finite volumes

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Abhijit; Ghosh, Sanjay K.; Ray, Rajarshi; Saha, Kinkar; Upadhaya, Sudipa

    2016-12-01

    We discuss the 2+1 flavor Polyakov loop enhanced Nambu-Jona-Lasinio model in a finite volume. The main objective is to check the volume scaling of thermodynamic observables for various temperatures and chemical potentials. We observe the possible violation of the scaling with system size in a considerable window along the whole transition region in the T\\text-μq plane.

  13. Reparametrizing the Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Abhijit; Ghosh, Sanjay K.; Maity, Soumitra; Raha, Sibaji; Ray, Rajarshi; Saha, Kinkar; Upadhaya, Sudipa

    2017-03-01

    The Polyakov-Nambu-Jona-Lasinio model has been quite successful in describing various qualitative features of observables for strongly interacting matter, that are measurable in heavy-ion collision experiments. The question still remains on the quantitative uncertainties in the model results. Such an estimation is possible only by contrasting these results with those obtained from first principles using the lattice QCD framework. Recently a variety of lattice QCD data were reported in the realistic continuum limit. Here we make a first attempt at reparametrizing the model so as to reproduce these lattice data. We find excellent quantitative agreement for the equation of state. Certain discrepancies in the charge and strangeness susceptibilities as well as baryon-charge correlation still remain. We discuss their causes and outline possible directions to remove them.

  14. Lung endothelial barrier protection by iloprost in the two-hit models of VILI involves inhibition of Rho signaling

    PubMed Central

    Birukova, Anna A.; Fu, Panfeng; Xing, Junjie; Cokic, Ivan; Birukov, Konstantin G.

    2010-01-01

    iloprost in the in vitro and in vivo two-hit models of VILI and supports consideration of iloprost as a new therapeutic treatment of VILI. PMID:20004361

  15. Mesonic states in the generalised Nambu-Jona-Lasinio theories

    NASA Astrophysics Data System (ADS)

    Nefediev, A. V.; Ribeiro, J. E. F. T.

    2005-04-01

    For any Nambu-Jona-Lasinio model of QCD with arbitrary nonlocal, instantaneous, quark current-current confining kernels, we use a generalised Bogoliubov technique to go beyond BCS level (in the large-NC limit) so as to explicitly build quark-antiquark compound operators for creating/annihilating mesons. In the Hamiltonian approach, the mesonic bound-state equations appear (from the generalised Bogoliubov transformation) as mass-gap-like equations which, in turn, ensure the absence, in the Hamiltonian, of mesonic Bogoliubov anomalous terms. We go further to demonstrate the one-to-one correspondence between Hamiltonian and Bethe-Salpeter approaches to non-local NJL-type models for QCD and give the corresponding "dictionary" necessary to "translate" the amplitudes built using the graphical Feynman rules to the terms of the Hamiltonian, and vice versa. We comment on the problem of multiple vacua existence in such type of models and argue that mesonic states in the theory should be prescribed to have an extra index — the index of the replica in which they are created. Then the completely diagonalised Hamiltonian should contain a sum over this new index. The method is proved to be general and valid for any instantaneous quark kernel.

  16. Predictive formulation of the Nambu-Jona-Lasinio model

    SciTech Connect

    Battistel, O. A.; Dallabona, G.; Krein, G.

    2008-03-15

    A novel strategy to handle divergences typical of perturbative calculations is implemented for the Nambu-Jona-Lasinio model and its phenomenological consequences investigated. The central idea of the method is to avoid the critical step involved in the regularization process, namely, the explicit evaluation of divergent integrals. This goal is achieved by assuming a regularization distribution in an implicit way and making use, in intermediary steps, only of very general properties of such regularization. The finite parts are separated from the divergent ones and integrated free from effects of the regularization. The divergent parts are organized in terms of standard objects, which are independent of the (arbitrary) momenta running in internal lines of loop graphs. Through the analysis of symmetry relations, a set of properties for the divergent objects are identified, which we denominate consistency relations, reducing the number of divergent objects to only a few. The calculational strategy eliminates unphysical dependencies of the arbitrary choices for the routing of internal momenta, leading to ambiguity-free, and symmetry-preserving physical amplitudes. We show that the imposition of scale properties for the basic divergent objects leads to a critical condition for the constituent quark mass such that the remaining arbitrariness is removed. The model becomes predictive in the sense that its phenomenological consequences do not depend on possible choices made in intermediary steps. Numerical results are obtained for physical quantities at the one-loop level for the pion and sigma masses and pion-quark and sigma-quark coupling constants.

  17. Gluon fragmentation functions in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Yang, Dong-Jing; Li, Hsiang-nan

    2016-09-01

    We derive gluon fragmentation functions in the Nambu-Jona-Lasinio (NJL) model by treating a gluon as a pair of color lines formed by a fictitious quark and antiquark (q q ¯). Gluon elementary fragmentation functions are obtained from the quark and antiquark elementary fragmentation functions for emitting specific mesons in the NJL model under the requirement that the q q ¯ pair maintains in the flavor-singlet state after meson emissions. An integral equation, which iterates the gluon elementary fragmentation functions to all orders, is then solved to yield the gluon fragmentation functions at a model scale. It is observed that these solutions are stable with respect to variation of relevant model parameters, especially after QCD evolution to a higher scale is implemented. We show that the inclusion of the gluon fragmentation functions into the theoretical predictions from only the quark fragmentation functions greatly improves the agreement with the SLD data for the pion and kaon productions in e+e- annihilation. Our proposal provides a plausible construct for the gluon fragmentation functions, which are supposed to be null in the NJL model.

  18. Gluon Fragmentation Functions in the Nambu-Jona-Lasinio Model

    NASA Astrophysics Data System (ADS)

    Yang, Dong-Jing; Li, Hsiang-nan

    We derive gluon fragmentation functions in the Nambu-Jona-Lasinio (NJL) model by approximating a gluon as a fictitious color-octet quark-anti-quark (qbar{q}) pair. Gluon elementary fragmentation functions are derived from the quark and anti-quark elementary fragmentation functions for emitting specific mesons in the NJL model under the requirement that the qbar{q} pair maintains in the flavor-singlet state after meson emission. An iteration method and an inverse matrix method based on the gluon elementary fragmentation functions then yield the gluon fragmentation functions at the model scale. It is found that the resultant gluon fragmentation functions are stable with respect to variation of relevant model parameters, especially after QCD evolution to a higher scale is implemented. We show that the inclusion of the gluon fragmentation functions into the theoretical predictions from only the quark fragmentation functions greatly improve the agreement with the SLD data for the pion and kaon productions in e+e- annihilation. Our proposal provides a plausible construct for the gluon fragmentation functions, which are supposed to be null in the NJL model.

  19. CRYOTHERAPY FOLLOWING VISUAL INSPECTION WITH ACETIC ACID AND LUGOL'S IODINE (VIA/VILI) IN KHWISERO, WESTERN KENYA: LESSON FROM THE FIELD AFFECTING POLICY AND PRACTICE.

    PubMed

    Ngichabe, S K; Muthaura, P N; Murungi, C; Muyoka, J; Omenge, E; Muchiri, L

    2013-10-01

    Cervical cancer can be prevented and mortality/morbidity reduced by early detection and referral. Developing countries are likely to benefit from more cost effective methods of screening and treatment. Visual inspection with acetic acid and Lugol's iodine (VIA/VILI) offers a see and treat solution thus an affordable and efficient way to identify pre-malignant lesions. Immediate treatment with cryotherapy can be offered if pre-malignant lesions are found on visual inspection. Cryotherapyis a simple procedure that is curative for dysplasia; it is likely to benefit cervical dysplasia cases picked early in resource poor settings, however there are several factors that hinder patients' access to this noble technique. Determine hindrances to cryotherapy for patients following positive results of VIA/VILI after referral. Cross sectional Study Khwisero, Western Kenya. Women attending a medical camp, willing to get screened for cervical cancer. One hundred and nine patients were screened; seventy three (66.97%) were negative for VIA/VILI, twenty one (19.26%) were positive and referred for cryotherapy. Reasons for lack of follow up were financial constraints, lack of medical personnel at referral centres and poor access to the referral facilities.19.26% of women identified with positive lesions required intervention. No patient received cryotherapy following referral. There is urgent need for availability of cryotherapy machines and training of personnel who can perform cryotherapy at the primary care level. Regional studies on knowledge attitudes and practices about VIA/VILI and cryotherapy are required to provide reasons for the poor uptake of this procedure.

  20. Test characteristics of visual inspection with 4% acetic acid (VIA) and Lugol's iodine (VILI) in cervical cancer screening in Kerala, India.

    PubMed

    Sankaranarayanan, Rengaswamy; Wesley, Ramani; Thara, Somanathan; Dhakad, Namrata; Chandralekha, Bharathykutty; Sebastian, Paul; Chithrathara, K; Parkin, Donald Maxwell; Nair, Madhavan Krishnan

    2003-09-01

    Simple and inexpensive methods based on visual examination of the cervix are currently being investigated as alternative methods of cervical screening. The test characteristics of visual inspection with 4% acetic acid (VIA), and Lugol's iodine (VILI) and conventional cytology were investigated in a cross-sectional study involving 4,444 women aged 25 to 65 years in Kerala, India. While detection of any acetowhite area constituted a low-threshold positive VIA, detection of well-defined, opaque acetowhite lesions close to or touching the squamocolumnar junction constituted a high-threshold positive VIA test. Detection of definite yellow iodine nonuptake areas in the transformation zone close to or touching the squamocolumnar junction constituted a positive VILI test. Cytology was considered positive if reported as atypia or worse lesions. All screened women were evaluated by colposcopy and biopsies were directed in 1,644 women (37.0%), which allowed the direct estimation of sensitivity, specificity and predictive values. The reference diagnosis was based on a combination of histology and/or colposcopy. True disease status was defined as CIN 2 and worse lesions. A total of 149 (3.4%) women had CIN 2 or worse lesions. The sensitivities of low-threshold VIA, high-threshold VIA, VILI and cytology to detect CIN 2 or worse disease were 88.6%, 82.6%, 87.2% and 81.9%, respectively; the corresponding specificities were 78.0%, 86.5%, 84.7% and 87.8%. Our results indicate that VIA and VILI are suitable alternate screening tests to cytology for detecting cervical neoplasia in low-resource settings.

  1. Nonet meson properties in the Nambu-Jona-Lasinio model with dimensional versus cutoff regularization

    SciTech Connect

    Inagaki, T.; Kimura, D.; Kohyama, H.; Kvinikhidze, A.

    2011-02-01

    The Nambu-Jona-Lasinio model with a Kobayashi-Maskawa-'t Hooft term is one low energy effective theory of QCD which includes the U{sub A}(1) anomaly. We investigate nonet meson properties in this model with three flavors of quarks. We employ two types of regularizations, the dimensional and sharp cutoff ones. The model parameters are fixed phenomenologically for each regularization. Evaluating the kaon decay constant, the {eta} meson mass and the topological susceptibility, we show the regularization dependence of the results and discuss the applicability of the Nambu-Jona-Lasinio model.

  2. Extensions and further applications of the nonlocal Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Hell, T.; Weise, W.; Kashiwa, K.

    2011-06-01

    The nonlocal Polyakov-loop-extended Nambu-Jona-Lasinio model is further improved by including momentum-dependent wave-function renormalization in the quark quasiparticle propagator. Both two- and three-flavor versions of this improved Polyakov-loop-extended Nambu-Jona-Lasinio model are discussed, the latter with inclusion of the (nonlocal) 't Hooft-Kobayashi-Maskawa determinant interaction in order to account for the axial U(1) anomaly. Thermodynamics and phases are investigated and compared with recent lattice-QCD results.

  3. Natural law Judaism? The genesis of bioethics in Hans Jonas, Leo Strauss, and Leon Kass.

    PubMed

    Vogel, Lawrence

    2006-01-01

    Leon Kass is much misunderstood. He is not simply a Republican ideologue who tailored his ideas to break out of the ivory tower and into the halls of power. Nor does he look simply to use human nature as a moral guide. When the full range of his writings is considered and set in the tradition of his teachers, Hans Jonas and Leo Strauss, what emerges is a natural law position colored by religious revelation.

  4. Emergence of a nonuniform pion condensate in the (1 + 1)-dimensional Nambu-Jona-Lasinio model

    SciTech Connect

    Gubina, N. V. Zhukovsky, V. Ch.; Klimenko, K. G.; Kurbanov, S. G.

    2013-11-15

    The (1 + 1)-dimensional Nambu-Jona-Lasinio model describing the system of two-flavor quarks is studied in the limit of a large number of colors in the presence of a baryon chemical potential Micro-Sign and an isospin chemical potential Micro-Sign {sub I}. The possible formation of a nonuniform pion condensate in dense quark matter is considered for the cases of both the massive and the massless model.

  5. Scalar-pseudoscalar meson behavior and restoration of symmetries in SU(3) Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Costa, P.; Ruivo, M. C.; de Sousa, C. A.; Hansen, H.; Alberico, W. M.

    2009-06-01

    The modification of mesonic observables in a hot medium is analyzed as a tool to investigate the restoration of chiral and axial symmetries in the context of the Polyakov-loop extended Nambu-Jona-Lasinio model. The results of the extended model lead to the conclusion that the effects of the Polyakov loop are fundamental for reproducing lattice findings. In particular, the partial restoration of the chiral symmetry is faster in the Polyakov-Nambu-Jona-Lasinio model than in the Nambu-Jona-Lasinio one, and it is responsible for several effects: the meson-quark coupling constants show a remarkable difference in both models, there is a faster tendency to recover the Okubo-Zweig-Iizuka rule, and finally the topological susceptibility nicely reproduces the lattice results around T/Tc≈1.0.

  6. Quark matter under strong magnetic fields in the Nambu-Jona-Lasinio model

    SciTech Connect

    Menezes, D. P.; Pinto, M. Benghi; Avancini, S. S.; Martinez, A. Perez; Providencia, C.

    2009-03-15

    In the present work we use the large-N{sub c} approximation to investigate quark matter described by the SU(2) Nambu-Jona-Lasinio model subject to a strong magnetic field. The Landau levels are filled in such a way that usual kinks appear in the effective mass and other related quantities. {beta} equilibrium is also considered and the macroscopic properties of a magnetar described by this quark matter is obtained. Our study shows that the magnetar masses and radii are larger if the magnetic field increases but only very large fields ({>=}10{sup 18} G) affect the equation of state in a non-negligible way.

  7. Thermal nonlocal Nambu-Jona-Lasinio model in the real time formalism

    SciTech Connect

    Loewe, M.; Morales, P.; Villavicencio, C.

    2011-05-01

    The real time formalism at finite temperature and chemical potential for the nonlocal Nambu-Jona-Lasinio model is developed in the presence of a Gaussian covariant regulator. We construct the most general thermal propagator, by means of the spectral function. As a result, the model involves the propagation of massive quasiparticles. The appearance of complex poles is interpreted as a confinement signal, and, in this case, we have unstable quasiparticles with a finite decay width. An expression for the propagator along the critical line, where complex poles start to appear, is also obtained. A generalization to other covariant regulators is proposed.

  8. Pion-photon transition distribution amplitudes in the Nambu-Jona-Lasinio model

    SciTech Connect

    Courtoy, A.; Noguera, S.

    2007-11-01

    We define the pion-photon transition distribution amplitudes (TDA) in a field theoretic formalism from a covariant Bethe-Salpeter approach for the determination of the bound state. We apply our formalism to the Nambu-Jona-Lasinio model, as a realistic theory of the pion. The obtained vector and axial TDAs satisfy all features required by general considerations. In particular, sum rules and the polynomiality condition are explicitly verified. We have numerically proved that the odd coefficients in the polynomiality expansion of the vector TDA vanish in the chiral limit. The role of PCAC and the presence of a pion pole are explicitly shown.

  9. Compact stars with a quark core within the Nambu-Jona-Lasinio (NJL) model

    SciTech Connect

    Lenzi, C. H.; Schneider, A. S.; Providencia, C.; Marinho, R. M. Jr.

    2010-07-15

    An ultraviolet cutoff dependent on the chemical potential as proposed by Casalbuoni et al. is used in the SU(3) Nambu-Jona-Lasinio model. The model is applied to the description of stellar quark matter and compact stars. It is shown that with a new cutoff parametrization it is possible to obtain stable hybrid stars with a quark core. A larger cutoff at finite densities leads to a partial chiral symmetry restoration of quark s at lower densities. A direct consequence is the onset of the s quark in stellar matter at lower densities and a softening of the equation of state.

  10. Dynamics and thermodynamics of a nonlocal Polyakov--Nambu--Jona-Lasinio model with running coupling

    SciTech Connect

    Hell, T.; Roessner, S.; Cristoforetti, M.; Weise, W.

    2009-01-01

    A nonlocal covariant extension of the two-flavor Nambu and Jona-Lasinio model is constructed, with built-in constraints from the running coupling of QCD at high-momentum and instanton physics at low-momentum scales. Chiral low-energy theorems and basic current algebra relations involving pion properties are shown to be reproduced. The momentum-dependent dynamical quark mass derived from this approach is in agreement with results from Dyson-Schwinger equations and lattice QCD. At finite temperature, inclusion of the Polyakov loop and its gauge invariant coupling to quarks reproduces the dynamical entanglement of the chiral and deconfinement crossover transitions as in the (local) Polyakov-loop-extended Nambu and Jona-Lasinio model, but now without the requirement of introducing an artificial momentum cutoff. Steps beyond the mean-field approximation are made including mesonic correlations through quark-antiquark ring summations. Various quantities of interest (pressure, energy density, speed of sound, etc.) are calculated and discussed in comparison with lattice QCD thermodynamics at zero chemical potential. The extension to finite quark chemical potential and the phase diagram in the (T,{mu})-plane are also discussed.

  11. Nambu-Jona-Lasinio model of homogeneous neutral quark matter: Pseudoscalar diquark condensates revisited

    NASA Astrophysics Data System (ADS)

    Basler, H.; Buballa, M.

    2010-03-01

    We use a Nambu-Jona-Lasinio type model to investigate the phase diagram of dense quark matter under neutron star conditions in mean-field approximation. The model contains self-consistently determined quark masses and allows for diquark condensation in the scalar as well as in the pseudoscalar channel. The latter gives rise to the possibility of K0 condensation in the color-flavor locked phase. In agreement with earlier studies we find that this CFLK0 phase covers large regions of the phase diagram and that the predominant part of this phase is fully gapped. We show, however, that there exists a region at very low temperatures where the CFLK0 solutions become gapless, possibly indicating an instability towards anisotropic or inhomogeneous phases. The physical significance of solutions with pseudoscalar diquark condensates in the 2SC phase is discussed as well.

  12. Beta function in the non-Abelian Nambu-Jona-Lasinio model in four dimensions

    SciTech Connect

    Alves, Van Sergio; Pinheiro, S. V. L.; Nascimento, Leonardo; Pena, Francisco

    2009-08-15

    In this paper we present the structure of the renormalization group in non-Abelian Nambu-Jona-Lasinio model up to 1-loop order. The model is not perturbatively renormalizable in the usual power counting sense, but it is treated as an effective theory, valid in a scale of energy in which p<<{lambda}, where p is the external momenta of the loop and {lambda} is a massive parameter that characterizes the couplings of the nonrenormalizable vertex. We clarify the tensorial structure of the interaction vertices and calculate the functions of the renormalization group. The analysis of the fixed points of the theory is also presented using Zimmermann's procedure for reducing the coupling constants. We find that the origin is an infrared-stable fixed point at low energies and also there is a nontrivial ultraviolet stable fixed point, indicating that the theory could be perturbatively investigated in the low momentum regime.

  13. Nonuniform phases in the 't Hooft extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Moreira, J.; Hiller, B.; Osipov, A. A.; Blin, A. H.

    2016-01-01

    The phase diagram of cold dense quark matter is studied using the 't Hooft extended Nambu-Jona-Lasinio Model applied to the light quark sector with a finite current mass for the strange quark (up and down are considered in the chiral limit). By relaxing the traditional uniformity assumptions and considering a modulated light quark condensate background we investigate the possible existence of non-uniform phases in this region of the phase diagram. The effects of changes in the coupling strengths of the model are studied and it is shown that the inclusion of flavour mixing combined with the finite current mass of the strange quark catalyses the appearance of the non-uniform phases, extending the domain for their existence.

  14. Color neutrality effects in the phase diagram of the Polyakov--Nambu--Jona-Lasinio model

    SciTech Connect

    Dumm, D. Gomez; Blaschke, D. B.; Grunfeld, A. G.; Scoccola, N. N.

    2008-12-01

    The phase diagram of a two-flavor Polyakov-loop Nambu-Jona-Lasinio model is analyzed imposing the constraint of color charge neutrality. The main effect of this constraint is a coexistence of the chiral symmetry breaking ({chi}SB) and two-flavor superconducting phases. Additional effects are a shrinking of the {chi}SB domain in the T-{mu} plane and a shift of the end point to lower temperatures, but their quantitative importance is shadowed by the intrinsic uncertainties of the model. The effects can be understood in view of the presence of a nonvanishing color chemical potential {mu}{sub 8}, which is introduced to compensate the color charge density {rho}{sub 8} induced by a background color gauge mean field {phi}{sub 3}. At low temperatures and large chemical potentials the model exhibits a quarkyonic phase, which gets additional support from the diquark condensation.

  15. Thermodynamics of a three-flavor nonlocal Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Hell, T.; Roessner, S.; Cristoforetti, M.; Weise, W.

    2010-04-01

    The present work generalizes a nonlocal version of the Polyakov-loop-extended Nambu and Jona-Lasinio (PNJL) model to the case of three active quark flavors, with inclusion of the axial U(1) anomaly. Gluon dynamics is incorporated through a gluonic background field, expressed in terms of the Polyakov loop. The thermodynamics of the nonlocal PNJL model accounts for both chiral and deconfinement transitions. Our results obtained in mean-field approximation are compared to lattice QCD results for N{sub f}=2+1 quark flavors. Additional pionic and kaonic contributions to the pressure are calculated in random phase approximation. Finally, this nonlocal three-flavor PNJL model is applied to the finite density region of the QCD phase diagram. It is confirmed that the existence and location of a critical point in this phase diagram depend sensitively on the strength of the axial U(1) breaking interaction.

  16. [Responsibility: Towards a fifth principle in blood transfusion's ethics. Applicability and limits of Hans Jonas's responsibility principle].

    PubMed

    Nélaton, C

    2016-09-01

    Nowadays, in France, anonymity, gratuity, volunteering, non-profit are recognized as ethical principles in blood transfusion. Can we add responsibility to this list? Can a logo named "Responsiblood" efficiently encourage blood donation? This article explores Hans Jonas's reform of the responsibility concept in order to measure its applicabilities and limits in the field of blood transfusion. Indeed, this concept - rethought by Jonas - seems to be a good encouragement which avoids the pitfalls of the concept of duty and of the idea of payment for blood donation. But can't we also see in this reform a threat to blood transfusion because of technophobia and the heuristics of fear that it involves?

  17. High density quark matter in the Nambu-Jona-Lasinio model with dimensional versus cutoff regularization

    SciTech Connect

    Fujihara, T.; Kimura, D.; Inagaki, T.; Kvinikhidze, A.

    2009-05-01

    We investigate color superconducting phase at high density in the extended Nambu-Jona-Lasinio model for two-flavor quarks. Because of the nonrenormalizability of the model, physical observables may depend on the regularization procedure; that is why we apply two types of regularization, the cutoff and the dimensional one to evaluate the phase structure, the equation of state, and the relationship between the mass and the radius of a dense star. To obtain the phase structure we evaluate the minimum of the effective potential at finite temperature and chemical potential. The stress tensor is calculated to derive the equation of state. Solving the Tolman-Oppenheimer-Volkoff equation, we show the relationship between the mass and the radius of a dense star. The dependence on the regularization is found not to be small, interestingly. The dimensional regularization predicts color superconductivity phase at rather large values of {mu} (in agreement with perturbative QCD in contrast to the cutoff regularization), in the larger temperature interval, the existence of heavier and larger quark stars.

  18. Symmetry energy and neutron star properties in the saturated Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Wei, Si-Na; Jiang, Wei-Zhou; Yang, Rong-Yao; Zhang, Dong-Rui

    2016-12-01

    In this work, we adopt the Nambu-Jona-Lasinio (NJL) model that ensures the nuclear matter saturation properties to study the density dependence of the symmetry energy. With the interactions constrained by the chiral symmetry, the symmetry energy shows novel characters different from those in conventional mean-field models. First, the negative symmetry energy at high densities that is absent in relativistic mean-field (RMF) models can be obtained in the RMF approximation by introducing a chiral isovector-vector interaction, although it would be ruled out by the neutron star (NS) stability. Second, with the inclusion of the isovector-scalar interaction the symmetry energy exhibits a general softening at high densities even for the large slope parameter of the symmetry energy. The NS properties obtained in the present NJL model can be in accord with the observations. The NS maximum mass obtained with various isovector-scalar couplings and momentum cutoffs is well above the 2M⊙, and the NS radius obtained well meets the limits extracted from recent measurements. In particular, the significant reduction of the canonical NS radius occurs with the moderate decrease of the slope of the symmetry energy.

  19. Deconfinement transition in protoneutron stars: Analysis within the Nambu-Jona-Lasinio model

    SciTech Connect

    Lugones, G.; Carmo, T. A. S. do; Grunfeld, A. G.; Scoccola, N. N.

    2010-04-15

    We study the effect of color superconductivity and neutrino trapping on the deconfinement transition of hadronic matter into quark matter in a protoneutron star. To describe the strongly interacting matter a two-phase picture is adopted. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3){sub f} Nambu-Jona-Lasinio effective model which includes color superconductivity. We impose color and flavor conservation during the transition in such a way that just deconfined quark matter is transitorily out of equilibrium with respect to weak interactions. We find that deconfinement is more difficult for small neutrino content and it is easier for lower temperatures although these effects are not too large. In addition they will tend to cancel each other as the protoneutron star cools and deleptonizes, resulting a transition density that is roughly constant along the evolution of the protoneutron star. According to these results the deconfinement transition is favored after substantial cooling and contraction of the protoneutron star.

  20. Thermomagnetic correlation lengths of strongly interacting matter in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ayala, Alejandro; Hernández, L. A.; Loewe, M.; Raya, Alfredo; Rojas, J. C.; Zamora, R.

    2017-08-01

    We study the correlation length between test quarks with the same electric and color charges in the Nambu-Jona-Lasinio model, considering thermal and magnetic effects. We extract the correlation length from the quark correlation function. The latter is constructed from the probability amplitude to bring a given quark into the plasma once a previous one with the same quantum numbers is placed at a given distance apart. For temperatures below the transition temperature, the correlation length starts growing as the field strength increases to then decrease for large magnetic fields. For temperatures above the pseudocritical temperature, the correlation length continues increasing as the field strength increases. We found that such behavior can be understood as a competition between the tightening induced by the classical magnetic force versus the random thermal motion. For large enough temperatures, the increase of the occupation number contributes to the screening of the interaction between the test particles. The growth of the correlation distance with the magnetic field can be understood as due to the closer proximity between one of the test quarks and the ones popped up from the vacuum, which in turn appear due to the increase of the occupation number with the temperature.

  1. Generalized Nambu-Goldstone pion in dense matter: A schematic Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Song, Yifan; Baym, Gordon

    2017-08-01

    Chiral symmetry is always broken in cold, dense matter, by chiral condensation at low densities and by diquark condensation at high density. We construct here, within a schematic Nambu-Jona-Lasinio model, the corresponding generalized Nambu-Goldstone pion, πG. As we show, the πG mode naturally emerges as a linear combination of the 〈q ¯q 〉 vacuum pion π and the 〈q q 〉 diquark-condensate pion π ˜, with q the quark field, and continuously evolves with increasing density from being π -like in the vacuum to π ˜-like in the high density diquark pairing phase. We calculate the density-dependent mass, decay constant, and coupling to quarks of the πG, and derive a generalized Gell-Mann-Oakes-Renner relation in the presence of a finite bare quark mass mq. We briefly discuss the implications of the results to possible Bose condensation of πG in more realistic models.

  2. Deconfinement of neutron star matter within the Nambu-Jona-Lasinio model

    SciTech Connect

    Lugones, G.; Grunfeld, A. G.; Scoccola, N. N.; Villavicencio, C.

    2009-08-15

    We study the deconfinement transition of hadronic matter into quark matter under neutron star conditions assuming color and flavor conservation during the transition. We use a two-phase description. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3){sub f} Nambu-Jona-Lasinio effective model including color superconductivity. Deconfinement is considered to be a first order phase transition that conserves color and flavor. It gives a short-lived transitory colorless-quark phase that is not in {beta} equilibrium, and decays to a stable configuration in {tau}{approx}{tau}{sub weak}{approx}10{sup -8} s. However, in spite of being very short lived, the transition to this intermediate phase determines the onset of the transition inside neutron stars. We find the transition free-energy density for temperatures typical of neutron star interiors. We also find the critical mass above which compact stars should contain a quark core and below which they are safe with respect to a sudden transition to quark matter. Rather independently on the stiffness of the hadronic equation of state (EOS) we find that the critical mass of hadronic stars (without trapped neutrinos) is in the range of {approx}1.5-1.8 solar masses. This is in coincidence with previous results obtained within the MIT bag model.

  3. Kaon condensation in a Nambu-Jona-Lasinio model at high density

    SciTech Connect

    Forbes, Michael McNeil

    2005-11-01

    We demonstrate a fully self-consistent microscopic realization of a kaon-condensed color-flavor locked state (CFLK{sup 0}) within the context of a mean-field Nambu-Jona-Lasinio (NJL) model at high density. The properties of this state are shown to be consistent with the QCD low-energy effective theory once the proper gauge neutrality conditions are satisfied, and a simple matching procedure is used to compute the pion decay constant, which agrees with the perturbative QCD result. The NJL model is used to compare the energies of the CFLK{sup 0} state to the parity even CFL state, and to determine locations of the metal/insulator transition to a phase with gapless fermionic excitations in the presence of a nonzero hypercharge chemical potential and a nonzero strange quark mass. The transition points are compared with results derived previously via effective theories and with partially self-consistent NJL calculations. We find that the qualitative physics does not change, but that the transitions are slightly lower.

  4. Quark matter and quark stars at finite temperature in Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Chu, Peng-Cheng; Li, Xiao-Hua; Wang, Bin; Dong, Yu-Min; Jia, Yu-Yue; Wang, Shu-Mei; Ma, Hong-Yang

    2017-08-01

    We extend the SU(3) Nambu-Jona-Lasinio (NJL) model to include two types of vector interaction. Using these two types of vector interaction in NJL model, we study the quark symmetry free energy in asymmetric quark matter, the constituent quark mass, the quark fraction, the equation of state (EOS) for β -equilibrium quark matter, the maximum mass of QSs at finite temperature, the maximum mass of proto-quark stars (PQSs) along the star evolution, and the effects of the vector interaction on the QCD phase diagram. We find that comparing zero temperature case, the values of quark matter symmetry free energy get larger with temperature increasing, which will reduce the difference between the fraction of u, d and s quarks and stiffen the EoS for β -equilibrium quark matter. In particular, our results indicate that the maximum masses of the quark stars increase with temperature because of the effects of the quark matter symmetry free energy, and we find that the heating(cooling) process for PQSs will increase (decrease) the maximum mass within NJL model.

  5. Chirally symmetric O(1/N{sub c}) corrections to the Nambu-Jona-Lasinio model

    SciTech Connect

    Dmitrasinovic, V.; Schulze, H.J.; Tegen, R.

    1995-03-01

    We develop an extended chirally symmetric self-consistent approximation scheme to the Nambu-Jona-Lasinio model, that corresponds to O(1/N{sub c}) corrections to the usual Hartree + random phase approximations. This scheme amounts to adding {open_quotes}meson cloud{close_quotes} contributions self-consistently to the quark self-energy and the meson polarization functions in a manner suggested by the weakly interacting nature of the quark and collective meson degrees of freedom of the NJL model in the large N{sub c} limit. We demonstrate explicitly that this scheme fulfills all the chiral symmetry theorems, namely the Goldstone theorem, the Goldberger-Treiman relation, and the conservation of the quark axial current. We explore the corrections to the quark self-energy and scalar condensate, as well as to the pion polarization function and the weak decay constant N{sub n}. The numerical evaluation of these corrections is presented and discussed. 23 refs., 14 figs., 2 tabs.

  6. Extended Nambu-Jona-Lasinio model and hidden local symmetry of low energy QCD

    NASA Astrophysics Data System (ADS)

    Wakamatsu, M.

    1996-11-01

    Using the standard auxiliary field method, we derive from the extended Nambu-Jona-Lasinio model an effective meson action containing vector and axial-vector mesons in addition to Goldstone bosons. The vector and axial-vector mesons in this effective action transform as gauge fields of hidden local symmetry Glocal=[U(n)L×U(n)R]local. Here, the realization of enlarged hidden local symmetry is accomplished via the introduction of two kinds of ``compensating'' fields. For obtaining the intrinsic-parity-violating part of the action, we generalize the standard gauged Wess-Zumino-Witten action such that it also contains two kinds of ``compensators'' in addition to the usual Goldstone bosons as well as the vector and axial-vector mesons. This generalized gauged Wess-Zumino-Witten action turns out to have Gglobal×Glocal symmetry, where Gglobal is the usual U(n)L×U(n)R global chiral symmetry while Glocal is the U(n)L×U(n)R hidden local symmetry. This means that Glocal has no gauge anomaly and its associated vector and axial-vector mesons can be regarded as gauge bosons of Glocal. The introduction of the coupling with the external electroweak fields requires us to gauge some appropriate subgroup of Gglobal. To make it consistent with the anomaly structure of QCD is a nontrivial problem. We explain how this can be done, following the recent suggestion by several authors.

  7. Thermal evolution of hybrid stars within the framework of a nonlocal Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    de Carvalho, S. M.; Negreiros, R.; Orsaria, M.; Contrera, G. A.; Weber, F.; Spinella, W.

    2015-09-01

    We study the thermal evolution of neutron stars containing deconfined quark matter in their core. Such objects are generally referred to as quark-hybrid stars. The confined hadronic matter in their core is described in the framework of nonlinear relativistic nuclear field theory. For the quark phase we use a nonlocal extension of the SU(3) Nambu-Jona-Lasinio model with vector interactions. The Gibbs condition is used to model phase equilibrium between confined hadronic matter and deconfined quark matter. Our study indicates that high-mass neutron stars may contain between 35 and 40% deconfined quark-hybrid matter in their cores. Neutron stars with canonical masses of around 1.4 M⊙ would not contain deconfined quark matter. The central proton fractions of the stars are found to be high, enabling them to cool rapidly. Very good agreement with the temperature evolution established for the neutron star in Cassiopeia A (Cas A) is obtained for one of our models (based on the popular NL3 nuclear parametrization), if the protons in the core of our stellar models are strongly paired, the repulsion among the quarks is mildly repulsive, and the mass of Cas A has a canonical value of 1.4 M⊙ .

  8. Color superconductivity in the Nambu-Jona-Lasinio model complemented by a Polyakov loop

    NASA Astrophysics Data System (ADS)

    Blanquier, Eric

    2017-06-01

    The color superconductivity is studied with the Nambu and Jona-Lasinio (NJL) model. This one is coupled to a Polyakov loop, to form the PNJL model. A μ-dependent Polyakov loop potential is also considered (μ PNJL model). An objective is to detail the analytical calculations that lead to the equations to be solved, in all of the treated cases. They are the normal quark (NQ), 2-flavor color-superconducting (2SC) and color-flavor-locked (CFL) phases, in an SU(3)f× SU(3)c description. The calculations are performed according to the temperature T , the chemical potentials μf or the densities ρf, with or without the isospin symmetry. The relation between the μf and ρf results is studied. The influence of the color superconductivity and the Polyakov loop on the found data is analyzed. A triple coincidence is observed at low T between the chiral restoration, the deconfinement transition described by the Polyakov loop and the NQ/2SC phase transition. Furthermore, an sSC phase is identified in the ρq, ρs plane. Possible links between certain of the obtained results and physical systems are pointed out.

  9. Interface tension and interface entropy in the 2+1 flavor Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ke, Wei-yao; Liu, Yu-xin

    2014-04-01

    We study the QCD phases and their transitions in the 2+1 flavor Nambu-Jona-Lasinio model, with a focus on the interface effects such as the interface tension, the interface entropy, and the critical bubble size in the coexistence region of the first-order phase transitions. Our results show that under the thin-wall approximation, the interface contribution to the total entropy density changes its discontinuity scale in the first-order phase transition. However, the entropy density of the dynamical chiral symmetry (DCS) phase is always greater than that of the dynamical chiral symmetry broken (DCSB) phase in both the heating and hadronization processes. To address this entropy puzzle, the thin-wall approximation is evaluated in the present work. We find that the puzzle can be attributed to an overestimate of the critical bubble size at low temperature in the hadronization process. With an improvement on the thin-wall approximation, the entropy puzzle is well solved with the total entropy density of the hadron-DCSB phase exceeding apparently that of the DCS-quark phase at low temperature.

  10. Nonlocal Ployakov-Nambu-Jona-Lasinio model and imaginary chemical potential

    SciTech Connect

    Kashiwa K.; Hell, T.; Weise, W.

    2011-09-21

    With the aim of setting constraints for the modeling of the QCD phase diagram, the phase structure of the two-flavor Polyakov-loop-extended Nambu and Jona-Lasinio (PNJL) model is investigated in the range of imaginary chemical potentials ({mu}{sub I}) and compared with available N{sub f} = 2 lattice QCD results. The calculations are performed using the advanced nonlocal version of the PNJL model with the inclusion of vector-type quasiparticle interactions between quarks, and with wave-function-renormalization corrections. It is demonstrated that the nonlocal PNJL model reproduces important features of QCD at finite {mu}{sub I}, such as the Roberge-Weiss (RW) periodicity and the RW transition. Chiral and deconfinement transition temperatures for N{sub f} = 2 turn out to coincide both at zero chemical potential and at finite {mu}{sub I}. Detailed studies are performed concerning the RW endpoint and its neighborhood where a first-order transition occurs.

  11. Thermodynamics and quark susceptibilities: A Monte Carlo approach to the Polyakov-Nambu-Jona-Lasinio model

    SciTech Connect

    Cristoforetti, M.; Hell, T.; Klein, B.; Weise, W.

    2010-06-01

    The Monte-Carlo method is applied to the Polyakov-loop extended Nambu-Jona-Lasinio model. This leads beyond the saddle-point approximation in a mean-field calculation and introduces fluctuations around the mean fields. We study the impact of fluctuations on the thermodynamics of the model, both in the case of pure gauge theory and including two quark flavors. In the two-flavor case, we calculate the second-order Taylor expansion coefficients of the thermodynamic grand canonical partition function with respect to the quark chemical potential and present a comparison with extrapolations from lattice QCD. We show that the introduction of fluctuations produces only small changes in the behavior of the order parameters for chiral symmetry restoration and the deconfinement transition. On the other hand, we find that fluctuations are necessary in order to reproduce lattice data for the flavor nondiagonal quark susceptibilities. Of particular importance are pion fields, the contribution of which is strictly zero in the saddle point approximation.

  12. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. . Inst. for Nuclear Theory Inst. fuer Theoretische Physik 2, Ruhr-Univ. Bochum ); Diakonov, D.; Petrov, V.; Pobylitsa, P.V. ); Park, N.W. Center for Theoretical Physics, Seoul National Univ. (Korea, Republic

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  13. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. |; Diakonov, D.; Petrov, V.; Pobylitsa, P.V.; Park, N.W. |

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle_times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  14. Unified composite scenario for inflation and dark matter in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Channuie, Phongpichit; Xiong, Chi

    2017-02-01

    In this work, we propose a cosmological scenario inherently based on the effective Nambu-Jona-Lasinio (NJL) model that cosmic inflation and dark matter can be successfully described by a single framework. On the one hand, the scalar channel of the NJL model plays a role of the composite inflaton (CI) and we show that it is viable to achieve successful inflation via a nonminimal coupling to gravity. For model of inflation, we compute the inflationary parameters and confront them with recent Planck 2015 data. We discover that the predictions of the model are in excellent agreement with the Planck analysis. We also present in our model a simple connection of physics from the high scales to low scales via renormalization group equations (RGEs) of the physical parameters and use them to estimate the range of relevant parameters. On the other hand, the pseudoscalar channel can be assigned as a candidate for composite dark matter (CD). For a model of dark matter, we couple the pseudoscalar to the Higgs sector of the standard model with the coupling strength κ and estimate its thermally averaged relic abundance. We discover that the CD mass is strongly sensitive to the coupling κ . We find in case of light CD, MsMW ,Z (or >Mh), the required relic abundance can be satisfied for value of the CD mass Ms˜410 GeV for κ =0.5 . In contradiction to the light mass case, however, the CD mass in this case can even be heavier when the coupling is getting larger.

  15. Thermomagnetic properties of the strong coupling in the local Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ayala, Alejandro; Dominguez, C. A.; Hernández, L. A.; Loewe, M.; Raya, Alfredo; Rojas, J. C.; Villavicencio, C.

    2016-09-01

    We study the thermomagnetic properties of the strong coupling constant G and quark mass M entering the Nambu-Jona-Lasinio model. For this purpose, we compute the quark condensate and compare it to lattice QCD (LQCD) results to extract the behavior of G and M as functions of the magnetic field strength and temperature. We find that at zero temperature, where the LQCD condensate is found to monotonically increase with the field strength, M also increases whereas G remains approximately constant. However, for temperatures above the chiral/deconfinement phase transitions, where the LQCD condensate is found to monotonically decrease with increasing field, M and G also decrease monotonically. For finite temperatures, below the transition temperature, we find that both G and M initially grow and then decrease with increasing field strength. To study possible consequences of the extracted temperature and magnetic field dependence of G and M , we compute the pressure and compare to LQCD results, finding an excellent qualitative agreement. In particular, we show that the transverse pressure, as a function of the field strength, is always negative for temperatures below the transition temperature whereas it starts off being positive and then becomes negative for temperatures above the transition temperature, also in agreement with LQCD results. We also show that for the longitudinal pressure to agree with LQCD calculations, the system should be described as a diamagnet. We argue that the turnover of M and G as functions of temperature and field strength is a key element that drives the behavior of the quark condensate going across the transition temperature and provides clues for a better understanding of the inverse magnetic catalysis phenomenon.

  16. Gauged Nambu-Jona-Lasinio model with extra dimensions: Phase structure and renormalizability

    SciTech Connect

    Gusynin, Valery P.; Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2004-11-01

    We investigate phase structure of the D(>4)-dimensional gauged Nambu-Jona-Lasinio (NJL) model with {delta}(=D-4) extra dimensions compactified on TeV scale, based on the improved ladder Schwinger-Dyson (SD) equation in the bulk. We assume that the bulk (dimensionless) running gauge coupling in the SD equation for the SU(N{sub c}) gauge theory with N{sub f} massless flavors is given by the truncated Kaluza-Klein effective theory and hence has a nontrivial ultraviolet fixed point (UVFP), resulting in the walking coupling. We find the critical line in the parameter space of two couplings, the gauge coupling (value fixed at the UVFP) and the (dimensionless) four-fermion coupling, which is similar to that of the gauged NJL model with fixed (walking) gauge coupling in four dimensions. It is shown that in the presence of such walking gauge interactions the four-fermion interactions become nontrivial and renormalizable even in higher dimensions, similar to the four dimensional gauged NJL model. Such a renormalizability/nontriviality holds only in the restricted region of the critical line ('nontrivial window') with the gauge coupling larger than a nonvanishing value ('marginal triviality' point), in contrast to the four dimensional case where such a renormalizability holds for all regions of the critical line except for the pure NJL point (without gauge coupling). In the nontrivial window the renormalized effective potential yields a nontrivial interaction which is conformal invariant. The existence of the nontrivial window implies 'cutoff insensitivity' of the physics prediction in spite of the ultraviolet dominance of the dynamics. In the formal limit D{yields}4, the nontrivial window shrinks to the pure NJL point but with a nontrivial condition which coincides with the known condition of the renormalizability/nontriviality of the four dimensional gauged NJL model (9/2)(1/N{sub c})

  17. Cosmological implications of Nambu-Jona-Lasinio model with a dynamical coupling

    NASA Astrophysics Data System (ADS)

    Quintanar, G. Leonardo; de La Macorra, Axel

    We study the cosmological implications of the Nambu-Jona-Lasinio (NJL) model when the coupling constant is field dependent. The NJL model has a four-fermion interaction describing two different phases due to quantum interaction effects and determined by the strength of the coupling constant g. It describes massless fermions for weak coupling and a massive fermions and strong coupling, where a fermion condensate is formed. In the original NJL model, the coupling constant g is indeed constant, and in this work we consider a modified version of the NJL model by introducing a dynamical field dependent coupling motivated by string theory. The effective potential as a function of the varying coupling (aimed to implement a natural phase transition) is seen to develop a negative divergence, i.e. becomes a “bottomless well” in certain limit region. Although we explain how an lower unbounded potential is not necessarily unacceptable in a cosmological context, the divergence can be removed if we consider a mass term for the coupling like field. We found that for a proper set of parameters, the total potential obtained has two minima, one located at the origin (the trivial solution, in which the fluid associated with the fields behave like matter); and the other related to the nontrivial solution. This last solution has three possibilities: (1) if the minimum is positive Vmin > 0, the system behaves as a cosmological constant, thus leading eventually to an accelerated universe; (2) if the minimized potential vanishes Vmin = 0, then we have matter with no acceleration; (3) finally a negative minimum Vmin < 0 leads an eventually collapsing universe with a flat geometry. Therefore, a possible interpretation as dark matter (DM) or dark energy (DE) is allowed among the behaviors implicated in the model.

  18. A study of diquark and meson condensation in the Nambu-Jona-Lasinio model and Fermi momentum

    NASA Astrophysics Data System (ADS)

    Ghosh, R.; Bhattacharya, A.; Chakrabarti, B.

    2017-01-01

    Using a three- and four-dimensional Pauli-Villars regularization scheme, we investigate quark-antiquark and diquark condensation in the framework of the Nambu-Jona-Lasinio model. Using the particle Fermi momentum as a cutoff parameter, we study the energy gap width and coherence length for the meson condensate . We also study the energy gap width and critical coherence length ( the distance over which there would be no diquark condensation) for the diquark < qq> and the dependence on the Fermi momentum. We obtain an estimate of the Fermi momentum value for meson and diquark condensates with an energy gap width of the order of 100 MeV.

  19. From scale properties of physical amplitudes to a predictive formulation of the Nambu-Jona-Lasinio model

    SciTech Connect

    Battistel, O. A.; Dallabona, G.

    2009-10-15

    The predictive power of the Nambu-Jona-Lasinio model is considered in the light of a novel strategy to handle the divergences typical of perturbative calculations. The referred calculational strategy eliminates unphysical dependencies on the arbitrary choices for the routing of internal momenta and symmetry violating terms. In the present work we extend a previous one on the same issue by including vector interactions and performing the discussion in a more general context: the role of scale arbitrariness for the consistency of the calculations is considered. We show that the imposition of arbitrary scale independence for the consistent regularized amplitudes lead to additional properties for the irreducible divergent objects. These properties allow us to parametrize the remaining freedom in terms of a unique constant where resides all the arbitrariness involved. By searching for the best value for the arbitrary parameter we find a critical condition for the existence of an acceptable physical value for the dynamically generated quark mass. Such critical condition fixes the remaining arbitrariness turning the Nambu-Jona-Lasinio into a predictive model in the sense that its phenomenological consequences do not depend on possible choices made in intermediary steps. Numerical results are obtained for physical quantities like the vector and axial-vector masses and their coupling constants as genuine predictions.

  20. Shear and bulk viscosities of quark matter from quark-meson fluctuations in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ghosh, Sabyasachi; Peixoto, Thiago C.; Roy, Victor; Serna, Fernando E.; Krein, Gastão

    2016-04-01

    We have calculated the temperature dependence of shear η and bulk ζ viscosities of quark matter due to quark-meson fluctuations. The quark thermal width originating from quantum fluctuations of quark-π and quark-σ loops at finite temperature is calculated with the formalism of real-time thermal field theory. Temperature-dependent constituent-quark and meson masses and quark-meson couplings are obtained in the Nambu-Jona-Lasinio model. We found a nontrivial influence of the temperature-dependent masses and couplings on the Landau-cut structure of the quark self-energy. Our results for the ratios η /s and ζ /s , where s is the entropy density (also determined in the Nambu-Jona-Lasinio model in the quasiparticle approximation), are in fair agreement with results of the literature obtained from different models and techniques. In particular, our result for η /s has a minimum very close to the quantum lower bound, η /s =1 /4 π .

  1. Quasiparticle properties of the quarks of the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Cao, Nan-Wei; Shakin, C. M.; Sun, Wei-Dong

    1992-12-01

    In spite of the apparent limitations of the model, in recent years there have been many applications of the Nambu-Jona-Lasinio (NJL) model in the study of hadron structure and in the study of the behavior of nuclear matter at finite temperature and density. A number of researchers have studied a generalized SU(3) version of the NJL model. For example, Vogl, Lutz, Klimt, and Weise [Nucl. Phys. A516 469 (1990)] have performed extensive calculations that include a calculation of a scalar form factor of a constituent quark, Fs(q2), and a calculation of a quark sigma term σq. (In their work, the latter quantity is related to the nucleon sigma term σN as in a constituent quark model: σN=3σq.) These calculations are made in what may be termed a sigma-dominance approximation. In the work reported here, we review the important role played by the nucleon sigma term in understanding the behavior of the quark condensate in the presence of matter. We make use of the original SU(2) version of the NJL model to study how various quark properties are modified when we take into account the dressing of the constituent quarks by the pion, the Goldstone boson of the model. We calculate the quark self-energy arising from emission and absorption of a pion and also show how the calculation of the scalar form factor of the quark and σq are modified due to the coupling of the quark to the pion. The correction terms considered here serve to reduce the value of σq by a small amount relative to the value obtained in the simplest version of the sigma dominance model. For example, for a Euclidean momentum cutoff, Λ=1050 MeV, the uncorrected result is σN=54.6 MeV. That value is then reduced to σN=51.5 MeV, if the corrections due to the pion ``dressing'' are included. It is also found that the residue at the quasiparticle pole of the quark propagator Z is about 0.86 when the coupling to the pion field is taken into account.

  2. Neutron stars: From the inner crust to the core with the (extended) Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Pais, Helena; Menezes, Débora P.; Providência, Constança

    2016-06-01

    Nucleonic matter is described within an SU(2) extended Nambu-Jona-Lasinio (NJL) model. Several parametrizations with different nuclear matter saturation properties are proposed. At subsaturation, nuclear pasta phases are calculated within two methods: the coexistence-phases approximation and the compressible liquid drop model, with the surface tension coefficient determined using a geometrical approach at zero temperature. A unified equation of state of stellar matter for the inner crust, with the nuclear pasta phases, and the core is calculated. The mass and radius of neutron stars within this framework are obtained for several families of hadronic and hybrid stars. The quark phase of hybrid stars is described within the SU(3) NJL model including a vector term. Stellar macroscopic properties are in accordance with some of the recent results in the literature.

  3. Phase diagram for the Nambu-Jona-Lasinio model with 't Hooft and eight-quark interactions

    NASA Astrophysics Data System (ADS)

    Hiller, B.; Moreira, J.; Osipov, A. A.; Blin, A. H.

    2010-06-01

    It is shown that the end point of the first-order transition line, which merges into a crossover regime in the phase diagram of the Nambu-Jona-Lasinio model, extended to include the six-quark ’t Hooft and eight-quark interaction Lagrangians, is pushed toward vanishing chemical potential and higher temperatures with increasing strength of the Okubo-Zweig-Iizuka-violating eight-quark interactions. We clarify the connection between the location of the end point in the phase diagram and the mechanism of chiral symmetry breaking at the quark level. We show how the 8q interactions affect the number of effective quark degrees of freedom. We are able to obtain the correct asymptotics for this number at large temperatures by using the Pauli-Villars regularization.

  4. Solitonic solutions of the SU(2) Nambu-Jona-Lasinio model with σ, π, ρ, A1 and ω mesons

    NASA Astrophysics Data System (ADS)

    Döring, F.; Schüren, C.; Arriola, E. Ruiz; Goeke, K.

    1993-01-01

    We present the first solitonic solutions of the SU(2) Nambu-Jona-Lasinio model including σ, π, ρ, A1 and ω mesons for hedgehog configurations on the chiral circle. The lagrangian incorporates Sakurai's universality and vector meson dominance by means of current-field identities. In order to fix the parameters of the lagrangian we make use of the full momentum dependent mesonic two point functions in the one quark loop approximation. For reasonable values of the consistuent quark mass we find that solitons exist provided that mω>870 MeV. In addition, whether the baryon number is carried by valence quarks or by the Dirac sea, depends strongly on the particular values of the constituent quark mass and the ω meson mass.

  5. A comparative study on two different approaches of bulk viscosity in the Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Saha, Kinkar; Upadhaya, Sudipa; Ghosh, Sabyasachi

    2017-02-01

    We have gone through a comparative study on two different kinds of bulk viscosity expressions by using a common dynamical model. The Polyakov-Nambu-Jona-Lasinio (PNJL) model in the realm of mean-field approximation, including up to eight quark interactions for 2+1 flavor quark matter, is treated for this common dynamics. We have probed the numerical equivalence as well as discrepancy of two different expressions for bulk viscosity at vanishing quark chemical potential. Our estimation of bulk viscosity to entropy density ratio follows a decreasing trend with temperature, which is observed in most of the earlier investigations. We have also extended our estimation for finite values of quark chemical potential.

  6. Spontaneous Electromagnetic Superconductivity of Vacuum in a Strong Magnetic Field: Evidence from the Nambu-Jona-Lasinio Model

    NASA Astrophysics Data System (ADS)

    Chernodub, M. N.

    2011-04-01

    Using an extended Nambu-Jona-Lasinio model as a low-energy effective model of QCD, we show that the vacuum in a strong external magnetic field (stronger than 1016T) experiences a spontaneous phase transition to an electromagnetically superconducting state. The unexpected superconductivity of, basically, empty space is induced by emergence of quark-antiquark vector condensates with quantum numbers of electrically charged rho mesons. The superconducting phase possesses an anisotropic inhomogeneous structure similar to a periodic Abrikosov lattice in a type-II superconductor. The superconducting vacuum is made of a new type of vortices which are topological defects in the charged vector condensates. The superconductivity is realized along the axis of the magnetic field only. We argue that this effect is absent in pure QED.

  7. Spontaneous electromagnetic superconductivity of vacuum in a strong magnetic field: evidence from the Nambu-Jona-Lasinio model.

    PubMed

    Chernodub, M N

    2011-04-08

    Using an extended Nambu-Jona-Lasinio model as a low-energy effective model of QCD, we show that the vacuum in a strong external magnetic field (stronger than 10(16)   T) experiences a spontaneous phase transition to an electromagnetically superconducting state. The unexpected superconductivity of, basically, empty space is induced by emergence of quark-antiquark vector condensates with quantum numbers of electrically charged rho mesons. The superconducting phase possesses an anisotropic inhomogeneous structure similar to a periodic Abrikosov lattice in a type-II superconductor. The superconducting vacuum is made of a new type of vortices which are topological defects in the charged vector condensates. The superconductivity is realized along the axis of the magnetic field only. We argue that this effect is absent in pure QED.

  8. Pion polarizability in the Nambu-Jona-Lasinio model and possibilities of its experimental studies in Coulomb nuclear scattering

    SciTech Connect

    Bystritskiy, Yu. M.; Guskov, A. V.; Pervushin, V. N.; Volkov, M. K.

    2009-12-01

    The charge pion polarizability is calculated in the Nambu-Jona-Lasinio model, where the quark loops (in the mean field approximation) and the meson loops (in the 1/N{sub c} approximation) are taken into account. We show that quark loop contribution dominates because the meson loops strongly conceal each other. The sigma-pole contribution (m{sub {sigma}}{sup 2}-t){sup -1} plays the main role and contains strong t-dependence of the effective pion polarizability at the region |t|{>=}4M{sub {pi}}{sup 2}. Possibilities of experimental test of this sigma-pole effect in the reaction of Coulomb nuclear scattering are estimated for the COMPASS experiment.

  9. A new species of sand crab Jonas Hombron & Jacquinot, 1846 (Crustacea:
    Decapoda: Brachyura: Corystidae) from the southeastern coast of India.

    PubMed

    Barathkumar, S; Das, N P I; Satpathy, K K

    2016-02-15

    A new species of sand crab of the genus Jonas Hombron & Jacquinot, 1846 (family Corystidae) is described from specimens collected from Kalpakkam, southeastern coast of India. Two other species, J. indicus (Chopra, 1935), and J. choprai Serène, 1971, have previously been recorded from this area. A detailed description of the new species is given and compared with the closely related J. formosae Balss, 1922, also from the Indo-West Pacific.

  10. Asymmetric pairing of realistic mass quarks and color neutrality in the Polyakov-Nambu-Jona-Lasinio model of QCD

    NASA Astrophysics Data System (ADS)

    Powell, Philip D.; Baym, Gordon

    2013-07-01

    We investigate the effects of realistic quark masses and local color neutrality on quark pairing in the three-flavor Polyakov-Nambu-Jona-Lasinio model. While prior studies have indicated the presence of light flavor quark (2SC) or symmetric color-flavor-locked (CFL) pairing at low temperatures, we find that in the absence of a local color neutrality constraint the inclusion of the Polyakov loop gives rise to phases in which all quark colors and flavors pair, but with unequal magnitudes. We study this asymmetric color-flavor-locked (ACFL) phase, which can exist even for equal mass quarks, identifying its location in the phase diagram, the order of the associated phase transitions, and its symmetry breaking pattern, which proves to be the intersection of the symmetry groups of the 2SC and CFL phases. We also investigate the effects of the strange quark mass on this new phase and the QCD phase diagram generally. Finally, we analyze the effect of a local color neutrality constraint on these phases of asymmetric pairing. We observe that for massless quarks the neutrality constraint renders the 2SC phase energetically unfavorable, eliminating it at low temperatures, and giving rise to the previously proposed low temperature critical point, with associated continuity between the hadronic and ACFL phases. For realistic strange quark masses, however, the neutrality constraint shrinks the 2SC region of the phase diagram, but does not eliminate it, at T=0.

  11. Extension of the Nambu-Jona-Lasinio model predictions at high densities and temperatures using an implicit regularization scheme

    SciTech Connect

    Farias, R. L. S.; Dallabona, G.; Krein, G.; Battistel, O. A.

    2008-06-15

    Traditional cutoff regularization schemes of the Nambu-Jona-Lasinio model limit the applicability of the model to energy-momentum scales much below the value of the regularizing cutoff. In particular, the model cannot be used to study quark matter with Fermi momenta larger than the cutoff. In the present work, an extension of the model to high temperatures and densities recently proposed by Casalbuoni, Gatto, Nardulli, and Ruggieri is used in connection with an implicit regularization scheme. This is done by making use of scaling relations of the divergent one-loop integrals that relate these integrals at different energy-momentum scales. Fixing the pion decay constant at the chiral symmetry breaking scale in the vacuum, the scaling relations predict a running coupling constant that decreases as the regularization scale increases, implementing in a schematic way the property of asymptotic freedom of quantum chromodynamics. If the regularization scale is allowed to increase with density and temperature, the coupling will decrease with density and temperature, extending in this way the applicability of the model to high densities and temperatures. These results are obtained without specifying an explicit regularization. As an illustration of the formalism, numerical results are obtained for the finite density and finite temperature quark condensate and applied to the problem of color superconductivity at high quark densities and finite temperature.

  12. Enforced neutrality and color-flavor unlocking in the three-flavor Polyakov-loop Nambu Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Abuki, H.; Ciminale, M.; Gatto, R.; Nardulli, G.; Ruggieri, M.

    2008-04-01

    We study how the charge neutrality affects the phase structure of the three-flavor Polyakov-loop Nambu Jona-Lasinio (PNJL) model. We point out that, within the conventional PNJL model at finite density, the color neutrality is missing because the Wilson line serves as an external colored field coupled to dynamical quarks. In this paper we heuristically assume that the model may still be applicable. To get color neutrality, one has then to allow nonvanishing color chemical potentials. We study how the quark matter phase diagram in (T,ms2/μ)-plane is affected by imposing neutrality and by including the Polyakov-loop dynamics. Although these two effects are correlated in a nonlinear way, the impact of the Polyakov loop turns out to be significant in the T direction, while imposing neutrality brings a remarkable effect in the ms2/μ direction. In particular, we find a novel unlocking transition, when the temperature is increased, even in the chiral SU(3) limit. We clarify how and why this is possible once the dynamics of the colored Polyakov loop is taken into account. Also we succeed in giving an analytic expression for Tc for the transition from two-flavor pairing (2SC) to unpaired quark matter in the presence of the Polyakov loop.

  13. BCS, Nambu-Jona-Lasinio, and Han-Nambu: A sketch of Nambu's works in 1960-1965

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2016-06-01

    The years 1960-1965 were a remarkable period for Yoichiro Nambu. Starting with a reformulation of BCS theory with emphasis on gauge invariance, he recognized the realization of spontaneous chiral symmetry breaking in particle physics as evidenced by the Goldberger-Treiman relation. A concrete model of Nambu and Jona-Lasinio illustrated the essence of the Nambu-Goldstone theorem and the idea of soft pions. After the proposal of the quark model by Gell-Mann, he together with Han constructed an alternative model of integrally charged quarks with possible non-Abelian gluons. All these remarkable works were performed during the years 1960-1965. Here I briefly review those works following the original papers of Nambu chronologically, together with a brief introduction to a formulation of Noether's theorem and the Ward-Takahashi identities using path integrals. This article is mostly based on a lecture given at the Nambu Memorial Symposium held at Osaka City University in September 2015, where Nambu started his professional career.

  14. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    DOE PAGES

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization schememore » for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.« less

  15. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    SciTech Connect

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization scheme for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.

  16. Radiative decays of radially excited mesons {pi}{sup 0'}, {rho}{sup 0'}, and {omega}{sup '} in the Nambu-Jona-Lasinio model

    SciTech Connect

    Kuraev, E. A.; Volkov, M. K.; Arbuzov, A. B.

    2010-12-15

    Radiative decays {pi}{sup 0}({pi}{sup 0'}){yields}{gamma}+{gamma}, {pi}{sup 0'{yields}{rho}0}({omega})+{gamma}, {rho}{sup 0'}({omega}{sup '}){yields}{pi}{sup 0}+{gamma}, and {rho}{sup 0'}({omega}{sup '}){yields}{pi}{sup 0'}+{gamma} are considered in the framework of the SU(2)xSU(2) Nambu-Jona-Lasinio (NJL) model. Radially excited mesons are described with the help of a simple polynomial form factor. In spite of mixing of the ground and excited meson states in this model, the decay widths of {pi}{sup 0{yields}{gamma}}+{gamma} and {rho}{sup 0}({omega}){yields}{pi}{sup 0}+{gamma} are found to be in good agreement with experimental data, as in the standard NJL model. Our predictions for decay widths of radially excited mesons can be verified in future experiments.

  17. Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2014-12-01

    The Swedish astronomer Anders Jonas Ångström, born two centuries ago and professor of physics at Uppsala University, was one of the founders of optical spectroscopy. By using diffraction gratings out of glass plates with fine scorings across the face, he was able to observe the spectrum of the Sun, announcing in 1862 that he had discovered the lines of hydrogen in the solar spectrum. His most important work, ;Recherches sur la Spectre Solaire;, including an atlas of close to a thousand spectral lines, became the standard of spectroscopy for at least a quarter of a century. This article deals with his life as well as his main contributions to the development of several areas of physical science, stressing his pioneer activities in spectroscopy.

  18. Decays τ → ντ( K*(892), K*(1410), K 1(1270), K 1(1650), a 1(1260), a 1(1640)) in the extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Volkov, M. K.; Nurlan, K.

    2017-09-01

    Intrinsic widths of the decays τ → ντ( K*(892), K*(1410), K 1(1270), K 1(1650), a 1(1260), a 1(1640)) are calculated in the framework of the extended Nambu-Jona-Lasinio model. The predictions for the decays τ → ντ( K*(892), K*(1410), K 1(1270) are in satisfactory agreement with the existing experimental data. Unfortunately, reliable data on the other three decays are still lacking.

  19. Role of two-flavor color superconductor pairing in a three-flavor Nambu-Jona-Lasinio model with axial anomaly

    NASA Astrophysics Data System (ADS)

    Basler, H.; Buballa, M.

    2010-11-01

    The phase diagram of strongly interacting matter is studied within a three-flavor Nambu-Jona-Lasinio model, which contains the coupling between chiral and diquark condensates through the axial anomaly. Our results show that it is essential to include the two-flavor color superconducting (2SC) phase in the analysis. While this is expected for realistic strange-quark masses, we find that even for equal up, down, and strange bare quark masses 2SC pairing can be favored due to spontaneous flavor symmetry breaking by the axial anomaly. This can lead to a rich phase structure, including BCS- and Bose-Einstein condensate-like 2SC and color-flavor locked phases and new endpoints. On the other hand, the low-temperature critical endpoint, which was found earlier in the same model without 2SC pairing, is almost removed from the phase diagram and cannot be reached from the low-density chirally broken phase without crossing a preceding first-order phase boundary. For physical quark masses no additional critical endpoint is found.

  20. Quark magnetar in three-flavor Nambu-Jona-Lasinio model under strong magnetic fields with two types of vector interactions

    NASA Astrophysics Data System (ADS)

    Chu, Peng-Cheng; Wang, Bin; Jia, Yu-Yue; Dong, Yu-Min; Wang, Shu-Mei; Li, Xiao-Hua; Zhang, Lei; Zhang, Xiao-Min; Ma, Hong-Yang

    2016-12-01

    We investigate the properties of strange quark matter (SQM) and quark stars (QSs) in the framework of SU(3) Nambu-Jona-Lasinio (NJL) model with two types of vector interactions under strong magnetic fields: (1) the flavor-dependent repulsion among u , d , and s quarks with the coupling constant GV, and (2) the universal repulsion and the vector-isovector interaction with the coupling constants gV and GI V. The effects of the two types of vector interactions on the constituent quark mass, vacuum quark mass, quark chemical potential, and quark fraction in SQM under strong magnetic fields are studied, and the results indicate that these physical quantities for SQM are all sensitive to the two types of vector interactions in NJL model under magnetic fields. Using a density-dependent magnetic field profile which is introduced to describe the magnetic field strength distribution inside the magnetars, we calculate the properties of spherical QSs by using two extreme cases for the orientation of the magnetic field inside the stars, i.e., the radial orientation in which the magnetic fields are along the radial direction in stars, and the transverse orientation in which the magnetic fields are randomly oriented in the plane which is perpendicular to the radial direction. Our results indicate that the maximum mass of QSs may dependent on both the strength distribution and the orientation of the magnetic fields inside QSs by using SU(3) NJL model.

  1. Finite-volume effects on phase transition in the Polyakov-loop extended Nambu-Jona-Lasinio model with a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Pan, Zan; Cui, Zhu-Fang; Chang, Chao-Hsi; Zong, Hong-Shi

    2017-05-01

    To investigate the finite-volume effects on the chiral symmetry restoration and the deconfinement transition for a quantum chromodynamics (QCD) system with Nf = 2 (two quark flavors), we apply the Polyakov-loop extended Nambu-Jona-Lasinio model by introducing a chiral chemical potential μ5 artificially. The final numerical results indicate that the introduced chiral chemical potential does not change the critical exponents, but shifts the location of critical end point (CEP) significantly; the ratios for the chiral chemical potentials and temperatures at CEP, μc/μ5c and Tc/T5c, are significantly affected by the system size R. The behavior is that Tc increases slowly with μ5 when R is “large” and Tc decreases first and then increases with μ5 when R is “small.” It is also found that for a fixed μ5, there is a Rmin, where the critical end point vanishes and the whole phase diagram becomes a crossover when R < Rmin. Therefore, we suggest that for the heavy-ion collision experiments, which is to study the possible location of CEP, the finite-volume behavior should be taken into account.

  2. Optimized perturbation theory applied to the study of the thermodynamics and BEC-BCS crossover in the three-color Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Duarte, Dyana C.; Farias, R. L. S.; Manso, Pedro H. A.; Ramos, Rudnei O.

    2017-09-01

    The Nambu-Jona-Lasinio model with two flavors, three colors, and diquark interactions is analyzed in the context of optimized perturbation theory (OPT). Corrections to the thermodynamical potential that go beyond the large-Nc (LN) approximation are taken into account, and the region of the phase diagram corresponding to intermediate chemical potentials and very low temperatures is explored. The simultaneous presence of both the quark-antiquark and diquark condensates can cause the system to behave as a fluid composed of a Bose-Einstein condensate (BEC) or a color superconductor one, in the form of a Bardeen-Cooper-Schrieffer (BCS) superfluid. The BEC-BCS crossover is then studied in the nonperturbative OPT scheme. The results obtained in the context of the OPT method are then contrasted with those obtained in the LN approximation. We show that there are values for the coupling constants related to quark-quark and quark-antiquark interactions where the corrections beyond LN brought by the OPT method can influence the behavior of the diquark condensate and the effective quark mass as a function of the baryon chemical potential. These changes in the behavior of the phase structure of the model modify the location of the critical point related to the phase structure as a whole of the model. Also, when we impose the color neutrality condition, our results show that the nature of the phase transition can change as well, shifting the ratio of the quark-antiquark and quark-quark interactions to higher values in the OPT case as compared to the LN approximation.

  3. Implications of the measurement of pulsars with two solar masses for quark matter in compact stars and heavy-ion collisions: A Nambu-Jona-Lasinio model case study

    NASA Astrophysics Data System (ADS)

    Klähn, T.; Łastowiecki, R.; Blaschke, D.

    2013-10-01

    The precise measurements of the high masses of the pulsars PSR J1614-2230 (M1614=1.97±0.04M⊙) and PSR J0348-0432 (M0348=2.01±0.04M⊙) provide an important constraint for the equation of state of cold, dense matter and are suited to give interesting insights regarding the nature and existence of the possible phase transition to deconfined quark matter in the cores of neutron stars. We analyze the stability and composition of compact star sequences for a class of hybrid nuclear-quark-matter equations of state. The quark matter phase is described in the framework of a standard color superconducting 3-flavor Nambu-Jona-Lasinio model, and the hadronic phase is given by the Dirac-Brueckner-Hartree-Fock equation of state for the Bonn-A potential. The phase transition is obtained by a Maxwell construction. Within this model setup, we aim to constrain otherwise not strictly fixed parameters of the Nambu-Jona-Lasinio model, namely, the coupling strengths in the vector meson and diquark interaction channels. We perform this investigation for two different parametrizations characterized by a different scalar coupling constant. The analysis of flow data obtained in heavy-ion collisions resulted in a further constraint that we account for in our discussion. Massive hybrid stars with extended quark matter cores can be obtained in accordance with all of the considered constraints.

  4. Phenomenological implications of a predictive formulation of the Nambu-Jona-Lasinio model having tensor couplings and isospin symmetry breaking terms

    NASA Astrophysics Data System (ADS)

    Battistel, O. A.; Pimenta, T. H.; Dallabona, G.

    2016-10-01

    In the present work we consider the phenomenological consequences of a predictive formulation of the Nambu-Jona-Lasinio (NJL) model at the one loop level of perturbative calculations. The investigation reported here can be considered as an extension of previously made ones on the same issue. In the study made in this work we have included vector and tensor couplings, simultaneously, as well as S U (2 ) isospin symmetry breaking terms. As a consequence of the last ingredient mentioned, there are different masses in the model amplitudes. In spite of this, within the context of the adopted procedure, we verify that it is possible to eliminate unphysical dependencies on the arbitrary choices for the routing of internal lines momenta as well as Ward identities violating contributions and scale ambiguous terms, from the corresponding one loop amplitudes, through the simple and universal Consistency Relations. The total content of divergence of the amplitudes is reduced to only two basic divergent objects. They are related to two inputs of the model in a way that, due to their scale properties, an unique arbitrariness remains. However, due to the critical condition found in the mechanism which generates the constituent quark mass, within our approach, this arbitrariness is also removed turning the model predictive in the sense that its phenomenological consequences is not dependent in possible choices made in intermediary steps of the calculations, as occurs in usual treatments. In this scenario, we investigate the most typical static properties of the scalar, pseudoscalar, vector and axial-vector mesons at low-energy. Special attention is given to the consequences of the S U (2 ) isospin symmetry breaking for the phenomenological predictions. The implications of the tensor couplings for the model observables, which can be considered an original contribution of the present work, at the level of the content and not only in the form, is analyzed in a detailed way. The found

  5. Aspects of U {sub A} (1) breaking in the Nambu and Jona-Lasinio model

    SciTech Connect

    Osipov, A.A. . E-mail: osipov@nusun.jinr.ru; Hiller, B. . E-mail: brigitte@teor.fis.uc.pt; Bernard, V. . E-mail: bernard@lpt6.u-strasbg.fr; Blin, A.H. . E-mail: alex@teor.fis.uc.pt

    2006-11-15

    The six-quark instanton induced 't Hooft interaction, which breaks the unwanted U {sub A} (1) symmetry of QCD, is a source of perturbative corrections to the leading order result formed by the four-quark forces with the U {sub L} (3) x U {sub R} (3) chiral symmetry. A detailed quantitative calculation is carried out to bosonize the model by the functional integral method. We concentrate our efforts on finding ways to integrate out the auxiliary bosonic variables. The functional integral over these variables cannot be evaluated exactly. We show that the modified stationary phase approach leads to a resummation within the perturbative series and calculate the integral in the 'two-loop' approximation. The result is a correction to the effective mesonic Lagrangian which may be important for the low-energy spectrum and dynamics of the scalar and pseudoscalar nonets.

  6. A modified Nambu-Jona-Lasinio model for mesons and baryons

    NASA Astrophysics Data System (ADS)

    Masayuki, Katô; Wolfgang, Bentz; Koichi, Yazaki; Kazuhiro, Tanaka

    1993-01-01

    A baryon-like bound state of three valence quarks in the NJL model is investigated. We find that in the flavor SU(2) case there exists no such state. Using the modified flavor SU(3) model we can obtain a baryon-like state. The essential ingredient which stabilizes the system is the "instanton-induced" six-fermion interaction describing the U A(1) anomaly in a phenomenological way. The properties of mesons are also investigated in this model.

  7. Nick Jonas on Type 1 Diabetes | NIH MedlinePlus the Magazine

    MedlinePlus

    ... be patient and don't get frustrated. NIDDK Research of Type 1 Diabetes TEDDY TEDDY (short for The Environmental ... 1 Diabetes Beyond Type 1 JDRF (Curing Diabetes Type 1 through research) FDA Approval of First Automated Insulin Device for ...

  8. The complete mitogenome of the marine bivalve Lutraria rhynchaena Jonas 1844 (Heterodonta: Bivalvia: Mactridae).

    PubMed

    Gan, Han Ming; Tan, Mun Hua; Thai, Binh Thanh; Austin, Christopher M

    2016-01-01

    The complete mitochondrial genome of the commercially important snout otter clam Lutraria rhynchaena was obtained from low-coverage shotgun sequencing data on the MiSeq platform. The L. rhynchaena mitogenome has 16,927 base pairs (69% A + T content) and made up of 12 protein-coding genes, 2 ribosomal subunit genes, 22 transfer RNAs, and a 953 bp non-coding AT-rich region. This is the first mitogenome to be sequenced from the genus Lutraria, and the seventh to be reported for the family Mactridae.

  9. Nonuniform phases in the ’t Hooft extended Nambu–Jona-Lasinio model

    SciTech Connect

    Moreira, J.; Hiller, B.; Blin, A. H.; Osipov, A. A.

    2016-01-22

    The phase diagram of cold dense quark matter is studied using the ’t Hooft extended Nambu-Jona–Lasinio Model applied to the light quark sector with a finite current mass for the strange quark (up and down are considered in the chiral limit). By relaxing the traditional uniformity assumptions and considering a modulated light quark condensate background we investigate the possible existence of non-uniform phases in this region of the phase diagram. The effects of changes in the coupling strengths of the model are studied and it is shown that the inclusion of flavour mixing combined with the finite current mass of the strange quark catalyses the appearance of the non-uniform phases, extending the domain for their existence.

  10. Nonlocal Polyakov-Nambu-Jona-Lasinio model with wave function renormalization at finite temperature and chemical potential

    SciTech Connect

    Contrera, G. A.; Orsaria, M.; Scoccola, N. N.

    2010-09-01

    We study the phase diagram of strongly interacting matter in the framework of a nonlocal SU(2) chiral quark model which includes wave function renormalization and coupling to the Polyakov loop. Both nonlocal interactions based on the frequently used exponential form factor, and on fits to the quark mass and renormalization functions obtained in lattice calculations are considered. Special attention is paid to the determination of the critical points, both in the chiral limit and at finite quark mass. In particular, we study the position of the critical end point as well as the value of the associated critical exponents for different model parametrizations.

  11. Hydrologic data of the coastal drainage basins of southeastern Massachusetts, Weir River, Hingham, to Jonas River, Kingston

    USGS Publications Warehouse

    Williams, John R.; Willey, Richard E.; Tasker, Gary D.

    1975-01-01

    This report presents, in tabular form, selected records of wells, test wells, borings, and springs; measurements of stream discharge, specific conductance, and temperature at partial-record stations; chemical analyses of ground water and surface water; and a summary of municipal water sources and additional sources available. The data were collected during a study of the drainage basins from 1969 to 1971 in cooperation with the Massachusetts Water Resources Commission. The report is released in order to make available to the public and to local, state, and federal agencies basic hydrologic information that may aid in planning water-resources development. Basic records contained in this report and streamflow data published elsewhere (U.S. Geol. Survey, 1960 et seq.) complement an interpretive report (Williams and Tasker, 1974).

  12. Variational path-integral approach to back-reactions of composite mesons in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Blaschke, D.; Ebert, D.

    2017-08-01

    For the investigation of back-reactions of composite mesons in the NJL model, a variational path-integral treatment is formulated which yields an effective action Aeff [Dσ ,Dπ ; S ], depending on the propagators Dσ, Dπ of σ- and π-mesons and on the full quark propagator S. The stationarity conditions δAeff / δS = 0, δAeff / δDσ = 0, δAeff / δDπ = 0, then lead to coupled Schwinger-Dyson (SD) equations for the quark self-energy and the meson polarization functions. These results reproduce and extend results of the so-called ;Φ-derivable; approach and provide a functional formulation for diagrammatic resummations of 1 /Nc -corrections in the NJL model. Finally, we perform a low-momentum estimate of the quark and meson loop contributions to the polarization function of the pion and on this basis discuss the Goldstone theorem.

  13. A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women.

    PubMed

    Huchko, Megan J; Sneden, Jennifer; Zakaras, Jennifer M; Smith-McCune, Karen; Sawaya, George; Maloba, May; Bukusi, Elizabeth Ann; Cohen, Craig R

    2015-01-01

    Visual inspection with Acetic Acid (VIA) and Visual Inspection with Lugol’s Iodine (VILI) are increasingly recommended in various cervical cancer screening protocols in low-resource settings. Although VIA is more widely used, VILI has been advocated as an easier and more specific screening test. VILI has not been well-validated as a stand-alone screening test, compared to VIA or validated for use in HIV-infected women. We carried out a randomized clinical trial to compare the diagnostic accuracy of VIA and VILI among HIV-infected women. Women attending the Family AIDS Care and Education Services (FACES) clinic in western Kenya were enrolled and randomized to undergo either VIA or VILI with colposcopy. Lesions suspicious for cervical intraepithelial neoplasia 2 or greater (CIN2+) were biopsied. Between October 2011 and June 2012, 654 were randomized to undergo VIA or VILI. The test positivity rates were 26.2% for VIA and 30.6% for VILI (p = 0.22). The rate of detection of CIN2+ was 7.7% in the VIA arm and 11.5% in the VILI arm (p = 0.10). There was no significant difference in the diagnostic performance of VIA and VILI for the detection of CIN2+. Sensitivity and specificity were 84.0% and 78.6%, respectively, for VIA and 84.2% and 76.4% for VILI. The positive and negative predictive values were 24.7% and 98.3% for VIA, and 31.7% and 97.4% for VILI. Among women with CD4+ count < 350, VILI had a significantly decreased specificity (66.2%) compared to VIA in the same group (83.9%, p = 0.02) and compared to VILI performed among women with CD4+ count ≥ 350 (79.7%, p = 0.02). VIA and VILI had similar diagnostic accuracy and rates of CIN2+ detection among HIV-infected women.

  14. Characterisation of 12 microsatellite loci in the Vietnamese commercial clam Lutraria rhynchaena Jonas 1844 (Heterodonta: Bivalvia: Mactridae) through next-generation sequencing.

    PubMed

    Thai, Binh Thanh; Tan, Mun Hua; Lee, Yin Peng; Gan, Han Ming; Tran, Trang Thi; Austin, Christopher M

    2016-05-01

    The marine clam Lutraria rhynchaena is gaining popularity as an aquaculture species in Asia. Lutraria populations are present in the wild throughout Vietnam and several stocks have been established and translocated for breeding and aquaculture grow-out purposes. In this study, we demonstrate the feasibility of utilising Illumina next-generation sequencing technology to streamline the identification and genotyping of microsatellite loci from this clam species. Based on an initial partial genome scan, 48 microsatellite markers with similar melting temperatures were identified and characterised. The 12 most suitable polymorphic loci were then genotyped using 51 individuals from a population in Quang Ninh Province, North Vietnam. Genetic variation was low (mean number of alleles per locus = 2.6; mean expected heterozygosity = 0.41). Two loci showed significant deviation from Hardy-Weinberg equilibrium (HWE) and the presence of null alleles, but there was no evidence of linkage disequilibrium among loci. Three additional populations were screened (n = 7-36) to test the geographic utility of the 12 loci, which revealed 100 % successful genotyping in two populations from central Vietnam (Nha Trang). However, a second population from north Vietnam (Co To) could not be successfully genotyped and morphological evidence and mitochondrial variation suggests that this population represents a cryptic species of Lutraria. Comparisons of the Qang Ninh and Nha Trang populations, excluding the 2 loci out of HWE, revealed statistically significant allelic variation at 4 loci. We reported the first microsatellite loci set for the marine clam Lutraria rhynchaena and demonstrated its potential in differentiating clam populations. Additionally, a cryptic species population of Lutraria rhynchaena was identified during initial loci development, underscoring the overlooked diversity of marine clam species in Vietnam and the need to genetically characterise population representatives prior to microsatellite development. The rapid identification and validation of microsatellite loci using next-generation sequencing technology warrant its integration into future microsatellite loci development for key aquaculture species in Vietnam and more generally, aquaculture countries in the South East Asia region.

  15. Evaluation of visual inspection with acetic acid and Lugol's iodine as cervical cancer screening tools in a low-resource setting.

    PubMed

    Qureshi, Sabuhi; Das, Vinta; Zahra, Fatima

    2010-01-01

    In view of the failure of cytology screening programmes for cervical cancer in developing countries, the World Health Organization suggested unaided visual inspection of the cervix after an application of acetic acid (VIA) and Lugol's iodine (VILI) as alternative screening methods. Our study evaluates the effectiveness of VIA and VILI compared to Pap smear as screening methods for carcinoma of the cervix in a low-resource setting. Three hundred and twenty-eight women were subjected to a Pap smear test, VIA, VILI and colposcopy. The results were as follows: Pap smear test (20.83%, specificity 98.38%), VIA (55.5%, 71.39%) and VILI (86.84%, 48.93%). Although VIA and VILI are less specific in comparison to the Pap smear test, they are more sensitive in detecting pre-invasive lesions. Hence VIA and VILI can be used as cervical cancer screening tools in low-resource settings.

  16. 77 FR 43350 - Draft Environmental Assessment and Proposed Habitat Conservation Plan for the San Diego Unified...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... San Diego Unified School District's Jonas Salk Elementary School Project in the City of San Diego, San... environmental assessment (EA) under the National Environmental Policy Act (NEPA) for the proposed Jonas Salk... information by any one of the following methods. Email: FW8cfwocomments@fws.gov . Include ``Jonas Salk...

  17. The Role of the Individual within Society: "The Giver" by Lois Lowry and "Brave New World" by Aldous Huxley. Thematic Unit.

    ERIC Educational Resources Information Center

    Tarner, Danielle; Umak, Adam

    Lois Lowry's award-winning novel, "The Giver," chronicles the strength of Jonas, an adolescent boy of 12 who lives in a utopian society. In the Community everyone is equal, and there is only a gray routine of existence. But Jonas is singled out by "The Giver," a wise old man who teaches Jonas the range of human emotions, and…

  18. Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

    PubMed Central

    Pan, Shuming; Fei, Aihua; Jing, Lihong; Zhang, Xiangyu

    2017-01-01

    Inappropriate mechanical ventilation (MV) can result in ventilator-induced lung injury (VILI). Probing mechanisms of VILI and searching for effective methods are current areas of research focus on VILI. The present study aimed to probe into mechanisms of endothelial microparticles (EMPs) in VILI and the protective effects of Tetramethylpyrazine (TMP) against VILI. In this study, C57BL/6 and TLR4KO mouse MV models were used to explore the function of EMPs associated with p21 activated kinases-4 (PAK-4) in VILI. Both the C57BL/6 and TLR4 KO groups were subdivided into a mechanical ventilation (MV) group, a TMP + MV group, and a control group. After four hours of high tidal volume (20 ml/kg) MV, the degree of lung injury and the protective effects of TMP were assessed. VILI inhibited the cytoskeleton-regulating protein of PAK4 and was accompanied by an increased circulating EMP level. The intercellular junction protein of β-catenin was also decreased accompanied by a thickening alveolar wall, increased lung W/D values, and neutrophil infiltration. TMP alleviated VILI via decreasing circulating EMPs, stabilizing intercellular junctions, and alleviating neutrophil infiltration. PMID:28261612

  19. A Randomized Trial Comparing the Diagnostic Accuracy of Visual Inspection with Acetic Acid to Visual Inspection with Lugol’s Iodine for Cervical Cancer Screening in HIV-Infected Women

    PubMed Central

    Huchko, Megan J.; Sneden, Jennifer; Zakaras, Jennifer M.; Smith-McCune, Karen; Sawaya, George; Maloba, May; Bukusi, Elizabeth Ann; Cohen, Craig R.

    2015-01-01

    Visual inspection with Acetic Acid (VIA) and Visual Inspection with Lugol’s Iodine (VILI) are increasingly recommended in various cervical cancer screening protocols in low-resource settings. Although VIA is more widely used, VILI has been advocated as an easier and more specific screening test. VILI has not been well-validated as a stand-alone screening test, compared to VIA or validated for use in HIV-infected women. We carried out a randomized clinical trial to compare the diagnostic accuracy of VIA and VILI among HIV-infected women. Women attending the Family AIDS Care and Education Services (FACES) clinic in western Kenya were enrolled and randomized to undergo either VIA or VILI with colposcopy. Lesions suspicious for cervical intraepithelial neoplasia 2 or greater (CIN2+) were biopsied. Between October 2011 and June 2012, 654 were randomized to undergo VIA or VILI. The test positivity rates were 26.2% for VIA and 30.6% for VILI (p = 0.22). The rate of detection of CIN2+ was 7.7% in the VIA arm and 11.5% in the VILI arm (p = 0.10). There was no significant difference in the diagnostic performance of VIA and VILI for the detection of CIN2+. Sensitivity and specificity were 84.0% and 78.6%, respectively, for VIA and 84.2% and 76.4% for VILI. The positive and negative predictive values were 24.7% and 98.3% for VIA, and 31.7% and 97.4% for VILI. Among women with CD4+ count < 350, VILI had a significantly decreased specificity (66.2%) compared to VIA in the same group (83.9%, p = 0.02) and compared to VILI performed among women with CD4+ count ≥ 350 (79.7%, p = 0.02). VIA and VILI had similar diagnostic accuracy and rates of CIN2+ detection among HIV-infected women. Trial Registration ClinicalTrials.gov NCT02237326 PMID:25849627

  20. Accuracy of visual inspection with acetic acid and with Lugol's iodine for cervical cancer screening: Meta-analysis.

    PubMed

    Qiao, Liang; Li, Bo; Long, Mei; Wang, Xiao; Wang, Anrong; Zhang, Guonan

    2015-09-01

    The aim of this review was to provide an updated summary estimation of the accuracy of visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI) in detecting cervical cancer and precancer. Studies on VIA/VILI accuracy were eligible in which VIA/VILI was performed on asymptomatic women who all underwent confirmatory testing of histology, combination of colposcopy and histology, or combination of multiple screening tests, colposcopy and histology, to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+ or CIN3+). A bivariate model was fitted to estimate the accuracy of VIA/VILI and provide estimates of heterogeneity. Subgroup analysis was used to investigate the source of heterogeneity. A total of 29 studies on VIA and 19 studies on VILI were included finally in the meta-analysis. The summary sensitivity and specificity of VIA for CIN2+ were 73.2% (95%CI: 66.5-80.0%) and 86.7% (95%CI: 82.9-90.4%), respectively, and those for VILI were 88.1% (95%CI: 81.5-94.7%) and 85.9% (95%CI: 81.7-90.0%), respectively. VIA and VILI were both more sensitive in detecting more severe outcome, although there was a slight loss in specificity. Apparent heterogeneity existed in sensitivity and specificity for both VIA and VILI. High sensitivity of both VIA and VILI for CIN2+ was found when a combination of colposcopy and histology was used as disease confirmation. VIA, VILI, even a combination of them in parallel, could be good options for cervical screening in low-resource settings. Significant differences in sensitivity between different gold standards might provide a proxy for optimization of ongoing cervical cancer screening programs.

  1. Corrigendum to "Historical review: Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth" [Spectrochim. Acta Part B, 102 (2014) 12-23

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2015-07-01

    The following addendum should be added to the Acknowledgments of the above article. Due to the multiplicity of simultaneous activities in which I am continuously involved, I forgot mentioning that Prof. Dr. Klaus Hentschel, of the History Department of the University of Stuttgart (Germany) was helpful in obtaining some of the source material used in my review. In particular, Prof. Hentschel provided the scans of Anne Beckmann's work to which I was guided by passages in his book on "Mapping the spectrum", Oxford University Press (2002). I also followed his recommendation of contacting the Swedish historians of science, and Prof. Sven Widmalm among them; however, the correspondence was not successful.

  2. Ventilator-induced Lung Injury

    PubMed Central

    Kneyber, Martin C. J.; Zhang, Haibo; Slutsky, Arthur S.

    2016-01-01

    It is well established that mechanical ventilation can injure the lung, producing an entity known as ventilator-induced lung injury (VILI). There are various forms of VILI, including volutrauma (i.e., injury caused by overdistending the lung), atelectrauma (injury due to repeated opening/closing of lung units), and biotrauma (release of mediators that can induce lung injury or aggravate pre-existing injury, potentially leading to multiple organ failure). Experimental data in the pediatric context are in accord with the importance of VILI, and appear to show age-related susceptibility to VILI, although a conclusive link between use of large Vts and mortality has not been demonstrated in this population. The relevance of VILI in the pediatric intensive care unit population is thus unclear. Given the physiological and biological differences in the respiratory systems of infants, children, and adults, it is difficult to directly extrapolate clinical practice from adults to children. This Critical Care Perspective analyzes the relevance of VILI to the pediatric population, and addresses why pediatric patients might be less susceptible than adults to VILI. PMID:25003705

  3. Mechanisms of ventilator-induced lung injury in healthy lungs.

    PubMed

    Silva, Pedro Leme; Negrini, Daniela; Rocco, Patricia Rieken Macêdo

    2015-09-01

    Mechanical ventilation is an essential method of patient support, but it may induce lung damage, leading to ventilator-induced lung injury (VILI). VILI is the result of a complex interplay among various mechanical forces that act on lung structures, such as type I and II epithelial cells, endothelial cells, macrophages, peripheral airways, and the extracellular matrix (ECM), during mechanical ventilation. This article discusses ongoing research focusing on mechanisms of VILI in previously healthy lungs, such as in the perioperative period, and the development of new ventilator strategies for surgical patients. Several experimental and clinical studies have been conducted to evaluate the mechanisms of mechanotransduction in each cell type and in the ECM, as well as the role of different ventilator parameters in inducing or preventing VILI. VILI may be attenuated by reducing the tidal volume; however, the use of higher or lower levels of positive end-expiratory pressure (PEEP) and recruitment maneuvers during the perioperative period is a matter of debate. Many questions concerning the mechanisms of VILI in surgical patients remain unanswered. The optimal threshold value of each ventilator parameter to reduce VILI is also unclear. Further experimental and clinical studies are necessary to better evaluate ventilator settings during the perioperative period in different types of surgery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. A Smartphone-Based Approach for Triage of Human Papillomavirus-Positive Sub-Saharan African Women: A Prospective Study.

    PubMed

    Urner, Esther; Delavy, Martine; Catarino, Rosa; Viviano, Manuela; Meyer-Hamme, Ulrike; Benski, Anne-Caroline; Jinoro, Jeromine; Heriniainasolo, Josea Lea; Undurraga, Manuela; De Vuyst, Hugo; Combescure, Christophe; Vassilakos, Pierre; Petignat, Patrick

    2017-05-29

    Sub-Saharan African countries are marked by a high incidence of cervical cancer. Madagascar ranks 11th among the countries with the highest cervical cancer incidence worldwide. The aim of the study was to evaluate the performances of digital smartphone-based visual inspection with acetic acid (D-VIA) and Lugol's iodine (D-VILI) for diagnosing cervical precancer and cancer. Human papillomavirus (HPV)-positive women recruited through a cervical screening campaign had D-VIA and D-VILI examinations with endocervical curettage (ECC) and cervical biopsy. Three images were captured for each woman (native, D-VIA, D-VILI) using a smartphone camera. The images were randomly coded and distributed on 2 online databases (Google Forms). The D-VIA form included native and D-VIA images, and the D-VILI form included native and D-VILI images. Pathological cases were defined as cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Physicians rated the images as non-pathological or pathological. Using the ECC and cervical biopsy results as references, the sensitivity and specificity of D-VIA and D-VILI examinations for each and all physicians were calculated. Altogether, 15 clinicians assessed 240 images. Sensitivity was higher for the D-VIA interpretations (94.1%; 95% CI 81.6-98.3) than for the D-VILI interpretations (78.8%; 95% CI 54.1-92.1; P=.009). In contrast, the specificity was higher for the D-VILI interpretations (56.4%; 95% CI 38.3-72.9) than for the D-VIA interpretations (50.4%; 95% CI 35.9-64.8; P=.005). Smartphone-based image for triage of HPV-positive women is more accurate for detecting CIN2+ lesions with D-VIA than D-VILI, although with a small loss of specificity.

  5. A comparison of two visual inspection methods for cervical cancer screening among HIV-infected women in Kenya.

    PubMed

    Huchko, Megan J; Sneden, Jennifer; Leslie, Hannah H; Abdulrahim, Naila; Maloba, May; Bukusi, Elizabeth; Cohen, Craig R

    2014-03-01

    To determine the optimal strategy for cervical cancer screening in women with human immunodeficiency virus (HIV) infection by comparing two strategies: visual inspection of the cervix with acetic acid (VIA) and VIA followed immediately by visual inspection with Lugol's iodine (VIA/VILI) in women with a positive VIA result. Data from a cervical cancer screening programme embedded in two HIV clinic sites in western Kenya were evaluated. Women at a central site underwent VIA, while women at a peripheral site underwent VIA/VILI. All women positive for cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) on VIA and/or VILI had a confirmatory colposcopy, with a biopsy if necessary. Overall test positivity, positive predictive value (PPV) and the CIN 2+ detection rate were calculated for the two screening methods, with biopsy being the gold standard. Between October 2007 and October 2010, 2338 women were screened with VIA and 1124 with VIA/VILI. In the VIA group, 26.4% of the women tested positive for CIN 2+; in the VIA/VILI group, 21.7% tested positive (P < 0.01). Histologically confirmed CIN 2+ was detected in 8.9% and 7.8% (P = 0.27) of women in the VIA and VIA/VILI groups, respectively. The PPV of VIA for biopsy-confirmed CIN 2+ in a single round of screening was 35.2%, compared with 38.2% for VIA/VILI (P = 0.41). The absence of any differences between VIA and VIA/VILI in detection rates or PPV for CIN 2+ suggests that VIA, an easy testing procedure, can be used alone as a cervical cancer screening strategy in low-income settings.

  6. A comparison of triage methods for Kenyan women who screen positive for cervical intraepithelial neoplasia by visual inspection of the cervix with acetic acid.

    PubMed

    Lewis, K C L; Tsu, V D; Dawa, A; Kidula, N A; Chami, I N; Sellors, J W

    2011-09-01

    Only about one in seven visual inspection with acetic acid (VIA)-positive women has high-grade disease; further confirmatory testing could rule out false positives. To determine if visual inspection with Lugol's iodine (VILI) or visual inspection with acetic acid and magnification (VIAM) can accurately confirm the presence of disease among rural Kenyan women referred to a district hospital because of a VIA-positive result at a primary health facility. Referred women received cervical cytology and either VILI and/or VIAM as triage methods. All women were assessed by colposcopy and biopsied, if necessary. Of the 490 VIA-positive subjects referred, 332 (68%) attended the district hospital and received at least one of two triage tests and cervical cytology. The sensitivity and specificity for histologically-confirmed CIN 2 and 3 were 93% (14/15) and 32% (52/161) for VIAM; 100% (3/3) and 77% (49/64) for VILI; and 80% (16/20) and 48% (110/228) for cervical cytology. VILI reduced the number of false-positive screening results by 73%, without missing any true positives. VILI had comparable sensitivity and significantly higher specificity compared to VIAM and cervical cytology. VILI may be a promising triage test for screen-positive women in low-resource settings; additional research is required.

  7. Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate.

    PubMed

    Aslami, Hamid; Kuipers, Maria T; Beurskens, Charlotte J P; Roelofs, Joris J T H; Schultz, Marcus J; Juffermans, Nicole P

    2012-02-01

    In the era of lung-protective mechanical ventilation using limited tidal volumes, higher respiratory rates are applied to maintain adequate minute volume ventilation. However, higher respiratory rates may contribute to ventilator-induced lung injury (VILI). Induced hypothermia reduces carbon dioxide production and might allow for lower respiratory rates during mechanical ventilation. We hypothesized that hypothermia protects from VILI and investigated whether reducing respiratory rates enhance lung protection in an in vivo model of VILI. During 4 h of mechanical ventilation, VILI was induced by tidal volumes of 18 mL/kg in rats, with respiratory rates set at 15 or 10 breaths/min in combination with hypothermia (32°C) or normothermia (37°C). Hypothermia was induced by external cooling. A physiologic model was established. VILI was characterized by increased pulmonary neutrophil influx, protein leak, wet weights, histopathology score, and cytokine levels compared with lung protective mechanical ventilation. Hypothermia decreased neutrophil influx, pulmonary levels, systemic interleukin-6 levels, and histopathology score, and it tended to decrease the pulmonary protein leak. Reducing the respiratory rate in combination with hypothermia did not reduce the parameters of the lung injury. In conclusion, hypothermia protected from lung injury in a physiologic VILI model by reducing inflammation. Decreasing the respiratory rate mildly did not enhance protection.

  8. Assessing the gain in diagnostic performance when two visual inspection methods are combined for cervical cancer prevention.

    PubMed

    Muwonge, Richard; Walter, Stephen D; Wesley, Ramani S; Basu, Partha; Shastri, Surendra S; Thara, Somanathan; Mbalawa, Charles Gombe; Sankaranarayanan, Rengaswamy

    2007-01-01

    The objectives of this study was to establish whether combined screening with visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) improves detection of cervical intraepithelial neoplasia 2-3 (CIN 2-3) lesions and cancer beyond chance, compared with screening with VIA alone or VILI alone; and to estimate the extra number of false-positive (FP) results per additional disease case found with the combined test, and to estimate the additional costs involved. Ten cross-sectional studies in Burkina Faso, Congo, Guinea, India, Mali and Niger, between 1999 and 2003. Using a common protocol, health workers screened 56,147 women aged 25-65 years with VIA and VILI. All women underwent a colposcopy examination and biopsies were taken when necessary. The disease reference standard was histology or negative colposcopy. A positive result on the combined test was defined if either VIA or VILI were positive. The accuracy of the combined test compared with VIA alone or VILI alone was evaluated using likelihood ratios. The estimated sensitivity and specificity were 81.3% and 87.3%, respectively, for VIA; 91.5% and 86.9% for VILI; and 92.9% and 83.5% for the combined test. The ratio of the positive likelihood ratios of the combined test and VIA alone for CIN 2-3 lesions and cancer was 0.88 (95% confidense interval [CI]: 0.86-0.90), favouring use of VIA alone. The ratio of the negative likelihood ratios was 0.40 (95% CI: 0.37-0.47), favouring use of the combined test. Similar results were obtained when the combined test was compared with VILI alone. Assuming equivalent performance of VIA alone and the combined test with a disease prevalence of 2%, there will be about 16.0 (95% CI: 13.6-18.8) additional FPs for each additional true positive (TP) detected if the combined test is used. This number will be 121.1 (95% CI: 75.4-194.6) if VILI is considered as the single test. At the trade-off point between the combined test and VIA alone or VILI alone, given the numbers of

  9. Ecology and Pedagogy: On the Educational Implications of Postwar Environmental Philosophy

    ERIC Educational Resources Information Center

    Hotam, Yotam

    2010-01-01

    Environmentalism, an ethical imperative to preserve and protect nature, has become in the last decade a central ethical, political and pedagogic theme. Against this background, this article focuses on the postwar philosophy of the German-Jewish scholar Hans Jonas (1903-93). It points to Jonas's radical theory of pedagogic responsibility, and to…

  10. Ecology and Pedagogy: On the Educational Implications of Postwar Environmental Philosophy

    ERIC Educational Resources Information Center

    Hotam, Yotam

    2010-01-01

    Environmentalism, an ethical imperative to preserve and protect nature, has become in the last decade a central ethical, political and pedagogic theme. Against this background, this article focuses on the postwar philosophy of the German-Jewish scholar Hans Jonas (1903-93). It points to Jonas's radical theory of pedagogic responsibility, and to…

  11. Single visit approach for management of cervical intraepithelial neoplasia by visual inspection & loop electrosurgical excision procedure

    PubMed Central

    Singla, Shilpa; Mathur, Sandeep; Kriplani, Alka; Agarwal, Nutan; Garg, Pradeep; Bhatla, Neerja

    2012-01-01

    Background & objectives: Developing a feasible and sustainable model of cervical cancer screening in developing countries continues to be a challenge because of lack of facilities and awareness in the population and poor compliance with screening and treatment. This study was aimed to evaluate a single visit approach (SVA) for the management of cervical intraepithelial neoplasia (CIN) using visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) along with loop electrosurgical excision procedure (LEEP) in women attending Gynaecology OPD in a tertiary care hospital in north India. Methods: In this hospital-based study, 450 women receiving opportunistic screening by conventional Pap cytology were also screened by VIA and VILI. VIA/VILI positive cases underwent same-day colposcopy and biopsy of all lesions. If the modified Reid score was >3, the patient underwent LEEP at the same visit. Results: Of the 450 women screened, 86 (19.1%) and 92 (20.5%) women were VIA and VILI positive, respectively. Detection rates of VIA, VILI and cytology findings at ASCUS threshold were 33.3, 35.5 and 24.4 per 1000, women, respectively to detect a lesion >CIN1. For detection of CIN2+ lesion, detection rates of VIA, VILI and cytology were 20, 22.2 and 22.2 per 1000 women, respectively. Sixteen patients with Reid score >3 underwent the See-and-treat protocol. The overtreatment rate was 12.5 per cent and the efficacy of LEEP was 81.3 per cent. There were no major complications. Interpretation & conclusions: The sensitivity of VIA/VILI was comparable to cytology. A single visit approach using visual screening methods at community level by trained paramedical personnel followed by a combination of ablative and excisional therapy can help to decrease the incidence of cervical neoplasia. PMID:22771589

  12. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury

    PubMed Central

    Kuethe, Dean O.; Filipczak, Piotr T.; Hix, Jeremy M.; Gigliotti, Andrew P.; Estépar, Raúl San José; Washko, George R.; Baron, Rebecca M.

    2016-01-01

    Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration (P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI. PMID:27288491

  13. Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury

    PubMed Central

    Aslami, Hamid; Heinen, André; Roelofs, Joris J. T. H.; Zuurbier, Coert J.; Schultz, Marcus J.

    2010-01-01

    Purpose Acute lung injury is characterized by an exaggerated inflammatory response and a high metabolic demand. Mechanical ventilation can contribute to lung injury, resulting in ventilator-induced lung injury (VILI). A suspended-animation-like state induced by hydrogen sulfide (H2S) protects against hypoxia-induced organ injury. We hypothesized that suspended animation is protective in VILI by reducing metabolism and thereby CO2 production, allowing for a lower respiratory rate while maintaining adequate gas exchange. Alternatively, H2S may reduce inflammation in VILI. Methods In mechanically ventilated rats, VILI was created by application of 25 cmH2O positive inspiratory pressure (PIP) and zero positive end-expiratory pressure (PEEP). Controls were lung-protective mechanically ventilated (13 cmH2O PIP, 5 cmH2O PEEP). H2S donor NaHS was infused continuously; controls received saline. In separate control groups, hypothermia was induced to reproduce the H2S-induced fall in temperature. In VILI groups, respiratory rate was adjusted to maintain normo-pH. Results NaHS dose-dependently and reversibly reduced body temperature, heart rate, and exhaled amount of CO2. In VILI, NaHS reduced markers of pulmonary inflammation and improved oxygenation, an effect which was not observed after induction of deep hypothermia that paralleled the NaHS-induced fall in temperature. Both NaHS and hypothermia allowed for lower respiratory rates while maintaining gas exchange. Conclusions NaHS reversibly induced a hypometabolic state in anesthetized rats and protected from VILI by reducing pulmonary inflammation, an effect that was in part independent of body temperature. Electronic supplementary material The online version of this article (doi:10.1007/s00134-010-2022-2) contains supplementary material, which is available to authorized users. PMID:20721529

  14. Cervical cancer screening with naked-eye visual inspection in Colombia.

    PubMed

    Murillo, Raul; Luna, Joaquin; Gamboa, Oscar; Osorio, Elkin; Bonilla, Jairo; Cendales, Ricardo

    2010-06-01

    To assess the accuracy of visual inspection provided by nurses through combining acetic acid (VIA) and Lugol's iodine (VILI) in a low-resource region of Colombia. A cross-sectional study with 4957 women was conducted to evaluate visual inspection techniques as the basis for see-and-treat approaches in cervical cancer control. All women underwent conventional cytology, VIA performed by nurses, and a combination of VIA and VILI. All women underwent colposcopy and biopsies were obtained for any positive test. A total of 762 women underwent biopsy, 4945 women were included in the analysis of conventional cytology, and 4957 were included in the analysis of VIA and VIA-VILI. Positivity rates were 1.3% and 4.3% for HSIL and LSIL cytology, 7.4% for VIA, and 10.1% for VIA-VILI. Sensitivity for cytology was 52.9% and 36.8% for LSIL and HSIL thresholds, 53.6% for VIA, and 68.1% for VIA-VILI. The corresponding specificity was 95.0%, 99.2%, 93.2%, and 90.8% respectively. The parallel combination of VIA-VILI and cytology LSIL-threshold revealed the best performance as a screening strategy. The use of VIA-VILI simulating colposcopic procedures and provided by nurses represents a good alternative for implementing see-and-treat programs in Latin America. Program constraints should be taken into account. Copyright 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  15. Analysis of the effectiveness of visual inspection with acetic acid/Lugol’s iodine in one-time and annual follow-up screening in rural China

    PubMed Central

    Li, Rong; Lewkowitz, Adam K.; Hu, Shang-Ying; Qiu, Hui; Zhang, Yan; Jiang, Hong-Wei; Zhang, Jin-Song; Li, Ming; Tong, Shao-Min; Zhang, Qiao-Yu

    2017-01-01

    Purpose Via a large population-based survey conducted in rural, southwestern China, we aim to evaluate the effect of visual inspection with acetic acid/Lugol’s iodine (VIA/VILI) on diagnosing cases of cervical cancer and of precancerous lesions while exploring the mode of cervical prevention and control in low-resource settings in China. Methods Women aged 30–59 years from Chongqing, China were recruited from 2006 to 2009. Participants underwent VIA/VILI, and, if positive, received colposcopy-directed or random biopsies. Women with negative VIA/VILI or biopsy-confirmed cervical intraepithelial neoplasia (CIN) 1 lesions diagnosed in the first round of screening were re-screened in the following year with the same procedure. Results In total, 10,269 women received VIA/VILI. The average age of participants was 40.9 ± 7.6 years. Overall, 0.85% (87/10,269) of women were diagnosed via pathology-confirmed biopsy with CIN1, 0.25% (26/10,269) with CIN2, 0.27% (28/10,269) with CIN3, and 0.02% (2/10,269) with cervical cancer. Over half (57.7%) of CIN2 lesions, the majority of CIN3 lesions (89.3%), and all cancer cases (100%) were detected in the first round of screening. Conclusion In a rural, low-resource setting in China, onetime VIA/VILI screening detected more than a half of CIN2 cases, most CIN3 cases and all the cervical cancer cases. Detection rates of CIN2 lesions significantly increased with a 1-year follow-up VIA/VILI screen. Therefore, if multiple cervical cancer screenings are not feasible logistically or financially, a one-time VIA/VILI may be the most efficient strategy to detect cervical cancer and most CIN3 lesions in women in low-resource settings. PMID:22222723

  16. Engineered Laser Filaments in Air for Defense Stand-Off Sensing and Interaction Applications

    DTIC Science & Technology

    2013-12-19

    Mark Ramme, Magali Durand , Matthieu Baudelet, Martin Richardson. Stand-off filament-induced ablation of gallium arsenide, Applied Physics Letters...07 2012): 0. doi: 10.1063/1.4734497 Magali Durand , Khan Lim, Vytautas Jukna, Erik McKee, Matthieu Baudelet, Aurélien Houard, Martin Richardson...Bernath and M. Richardson, “RF emissions from filament-matter interaction”, COFIL 2012, Tucson, AZ, USA, 2012. [4] M. Durand , A. Jarnac, S

  17. Pathologic Mechanical Stress and Endotoxin Exposure Increases Lung Endothelial Microparticle Shedding

    PubMed Central

    Letsiou, Eleftheria; Sammani, Saad; Zhang, Wei; Zhou, Tong; Quijada, Hector; Moreno-Vinasco, Liliana; Dudek, Steven M.

    2015-01-01

    Acute lung injury (ALI) results from infectious challenges and from pathologic lung distention produced by excessive tidal volume delivered during mechanical ventilation (ventilator-induced lung injury [VILI]) and is characterized by extensive alveolar and vascular dysfunction. Identification of novel ALI therapies is hampered by the lack of effective ALI/VILI biomarkers. We explored endothelial cell (EC)-derived microparticles (EMPs) (0.1–1 μm) as potentially important markers and potential mediators of lung vascular injury in preclinical models of ALI and VILI. We characterized EMPs (annexin V and CD31 immunoreactivity) produced from human lung ECs exposed to physiologic or pathologic mechanical stress (5 or 18% cyclic stretch [CS]) or to endotoxin (LPS). EC exposure to 18% CS or to LPS resulted in increased EMP shedding compared with static cells (∼ 4-fold and ∼ 2.5-fold increases, respectively). Proteomic analysis revealed unique 18% CS–derived (n = 10) and LPS-derived EMP proteins (n = 43). VILI-challenged mice (40 ml/kg, 4 h) exhibited increased plasma and bronchoalveolar lavage CD62E (E-selectin)-positive MPs compared with control mice. Finally, mice receiving intratracheal instillation of 18% CS–derived EMPs displayed significant lung inflammation and injury. These findings indicate that ALI/VILI-producing stimuli induce significant shedding of distinct EMP populations that may serve as potential ALI biomarkers and contribute to the severity of lung injury. PMID:25029266

  18. Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding.

    PubMed

    Letsiou, Eleftheria; Sammani, Saad; Zhang, Wei; Zhou, Tong; Quijada, Hector; Moreno-Vinasco, Liliana; Dudek, Steven M; Garcia, Joe G N

    2015-02-01

    Acute lung injury (ALI) results from infectious challenges and from pathologic lung distention produced by excessive tidal volume delivered during mechanical ventilation (ventilator-induced lung injury [VILI]) and is characterized by extensive alveolar and vascular dysfunction. Identification of novel ALI therapies is hampered by the lack of effective ALI/VILI biomarkers. We explored endothelial cell (EC)-derived microparticles (EMPs) (0.1-1 μm) as potentially important markers and potential mediators of lung vascular injury in preclinical models of ALI and VILI. We characterized EMPs (annexin V and CD31 immunoreactivity) produced from human lung ECs exposed to physiologic or pathologic mechanical stress (5 or 18% cyclic stretch [CS]) or to endotoxin (LPS). EC exposure to 18% CS or to LPS resulted in increased EMP shedding compared with static cells (∼ 4-fold and ∼ 2.5-fold increases, respectively). Proteomic analysis revealed unique 18% CS-derived (n = 10) and LPS-derived EMP proteins (n = 43). VILI-challenged mice (40 ml/kg, 4 h) exhibited increased plasma and bronchoalveolar lavage CD62E (E-selectin)-positive MPs compared with control mice. Finally, mice receiving intratracheal instillation of 18% CS-derived EMPs displayed significant lung inflammation and injury. These findings indicate that ALI/VILI-producing stimuli induce significant shedding of distinct EMP populations that may serve as potential ALI biomarkers and contribute to the severity of lung injury.

  19. Negative pressure ventilation and positive pressure ventilation promote comparable levels of ventilator-induced diaphragmatic dysfunction in rats.

    PubMed

    Bruells, Christian S; Smuder, Ashley J; Reiss, Lucy K; Hudson, Matthew B; Nelson, William Bradley; Wiggs, Michael P; Sollanek, Kurt J; Rossaint, Rolf; Uhlig, Stefan; Powers, Scott K

    2013-09-01

    Mechanical ventilation is a life-saving intervention for patients with respiratory failure. Unfortunately, a major complication associated with prolonged mechanical ventilation is ventilator-induced diaphragmatic atrophy and contractile dysfunction, termed ventilator-induced diaphragmatic dysfunction (VIDD). Emerging evidence suggests that positive pressure ventilation (PPV) promotes lung damage (ventilator-induced lung injury [VILI]), resulting in the release of signaling molecules that foster atrophic signaling in the diaphragm and the resultant VIDD. Although a recent report suggests that negative pressure ventilation (NPV) results in less VILI than PPV, it is unknown whether NPV can protect against VIDD. Therefore, the authors tested the hypothesis that compared with PPV, NPV will result in a lower level of VIDD. Adult rats were randomly assigned to one of three experimental groups (n = 8 each): (1) acutely anesthetized control (CON), (2) 12 h of PPV, and (3) 12 h of NPV. Dependent measures included indices of VILI, diaphragmatic muscle fiber cross-sectional area, diaphragm contractile properties, and the activity of key proteases in the diaphragm. Our results reveal that no differences existed in the degree of VILI between PPV and NPV animals as evidenced by VILI histological scores (CON = 0.082 ± 0.001; PPV = 0.22 ± 0.04; NPV = 0.25 ± 0.02; mean ± SEM). Both PPV and NPV resulted in VIDD. Importantly, no differences existed between PPV and NPV animals in diaphragmatic fiber cross-sectional area, contractile properties, and the activation of proteases. These results demonstrate that NPV and PPV result in similar levels of VILI and that NPV and PPV promote comparable levels of VIDD in rats.

  20. Concurrent evaluation of visual, cytological and HPV testing as screening methods for the early detection of cervical neoplasia in Mumbai, India.

    PubMed Central

    Shastri, Surendra S.; Dinshaw, Ketayun; Amin, Geetanjali; Goswami, Smriti; Patil, Sharmila; Chinoy, Roshini; Kane, S.; Kelkar, Rohini; Muwonge, Richard; Mahé, Cédric; Ajit, Dulhan; Sankaranarayanan, R.

    2005-01-01

    OBJECTIVE: Naked eye visual inspection with acetic acid (VIA), magnified VIA (VIAM), visual inspection with Lugol's iodine (VILI), cytology and human papillomavirus (HPV) testing were evaluated as screening methods for the detection of high-grade squamous intraepithelial lesions (HSIL) of the uterine cervix in a cross-sectional study in Mumbai, India. METHODS: Cytology, HPV testing, VIA, VIAM and VILI were carried out concurrently for 4039 women aged 30-65 years. All women were investigated with colposcopy and biopsies were taken from 939 women who had colposcopic abnormalities. The reference standard for final disease status was histology or negative colposcopy. The presence of HSIL was confirmed in 57 women (1.4%). The test characteristics for each method were calculated using standard formulae. RESULTS: The sensitivities of cytology, HPV testing, VIA, VIAM and VILI were 57.4%, 62.0%, 59.7%, 64.9%, and 75.4%, respectively (differences were not statistically significant). The specificities were 98.6%, 93.5%, 88.4%, 86.3%, and 84.3%, respectively. Adding a visual test to cytology or HPV testing in parallel combination resulted in a substantial increase in sensitivity, with a moderate decrease in specificity. The parallel combination of VILI and HPV testing resulted in a sensitivity of 92.0% and a specificity of 79.9%. CONCLUSION: As a single test, cytology had the best balance of sensitivity and specificity. Visual tests are promising in low-resource settings, such as India. The use of both VIA and VILI may be considered where good quality cytology or HPV testing are not feasible. The sensitivity of cytology and HPV testing increased significantly when combined with VIA or VILI. PMID:15798842

  1. Could Fading Sense of Smell Mean Death Is Closer?

    MedlinePlus

    ... brain health," said Olofsson, an associate professor of psychology at Stockholm University. "We see smell function as ... Society . SOURCES: Jonas Olofsson, Ph.D., associate professor, psychology, Stockholm University, Sweden; Carla Schubert, M.S., researcher, department ...

  2. The Use of Acupuncture in the U.S. Military: Challenges and Opportunities

    DTIC Science & Technology

    2011-01-01

    ROUNDTABLE DISCUSSION The Use of Acupuncture in the U.S. Military: Challenges and Opportunities Moderator: Wayne B. Jonas, MD1 Participants: Richard...Capt, US Navy,5,{ Joan A.G. Walter, JD, PA,1 and Stephen M. Burns, MD, Col (Ret), USAF, MC, FS2,* Medical Acupuncture was privileged to host...aroundtable discussion among military leaders and acupuncture specialists late last summer. Moderated by Dr. Wayne B. Jonas, the discussion focuses on exciting

  3. Cloud Simulation Warm Cloud Experiments: Droplet Growth and Aerosol Scavenging.

    DTIC Science & Technology

    1988-03-02

    cloud simulation facility capabilities and experiments (Hagen, Alcorn, Alofs, Anderson, Carstens, Hopkins, Salk , Schmitt, Trueblood, White) 4. Conference...Snowmass, CO, AMS, 145-148. Jonas , P.R., and B.J. Mason, 1982: Entrainment and the droplet spectrumin cumulus clouds. Quart. J. Roy. Meteor. Soc. 108...distribution near the base of cumulus clouds. Quart. J. Roy. Meteor. Soc. 108, 917-928. Mason, B.J., and P.R. Jonas , 1984: The evolution of droplet

  4. Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications?

    PubMed Central

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is widely accepted as a rescue therapy in patients with acute life-threatening hypoxemia in the course of severe acute respiratory distress syndrome (ARDS). However, possible side effects and complications are considered to limit beneficial outcome effects. Therefore, widening indications with the aim of reducing ventilator induced lung injury (VILI) is still controversial. Consequently, technological progress is an important strategy. Miniaturized ECMO systems are believed to simplify handling and reduce side effects and complications. Mueller and co-workers evaluated such a small-sized device in 60 patients with severe ARDS. They accomplished both the treatment of severe hypoxemia and reduction of VILI, demonstrating feasibility, a moderate rate of severe complications, and a 45% intensive care survival rate. Although neither randomized nor controlled, this study should encourage others to implement such systems in clinical practice. From a strategic perspective, this is another small but useful step towards implementing extracorporeal gas exchange for the prevention of VILI. It is already common sense that the prevention of acute life-threatening hypoxemia usually outweighs the risks of this technique. The next step should be to prove that prevention of life-threatening VILI balances the risks too. PMID:20236482

  5. Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications?

    PubMed

    Dembinski, Rolf; Kuhlen, Ralf

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is widely accepted as a rescue therapy in patients with acute life-threatening hypoxemia in the course of severe acute respiratory distress syndrome (ARDS). However, possible side effects and complications are considered to limit beneficial outcome effects. Therefore, widening indications with the aim of reducing ventilator induced lung injury (VILI) is still controversial. Consequently, technological progress is an important strategy. Miniaturized ECMO systems are believed to simplify handling and reduce side effects and complications. Mueller and co-workers evaluated such a small-sized device in 60 patients with severe ARDS. They accomplished both the treatment of severe hypoxemia and reduction of VILI, demonstrating feasibility, a moderate rate of severe complications, and a 45% intensive care survival rate. Although neither randomized nor controlled, this study should encourage others to implement such systems in clinical practice. From a strategic perspective, this is another small but useful step towards implementing extracorporeal gas exchange for the prevention of VILI. It is already common sense that the prevention of acute life-threatening hypoxemia usually outweighs the risks of this technique. The next step should be to prove that prevention of life-threatening VILI balances the risks too.

  6. Rapid Nonconjugate Adaptation of Vertical Voluntary Pursuit Eye Movements

    DTIC Science & Technology

    1991-01-01

    1967), Extension of Panum’s fusional area in binocularly stabilized vision, J. Opt. Soc. Am. 57:819 64 Henson DB and Dharamshi BG (1982), Oculomotor...Ophthalmol. 22:743 Vilis T, Snow R, and Hore J (1983), Cerebellar saccadic dysmetria is not equal in the two eyes, Exp. Brain Res. 51:343 Virre E, Cadera W

  7. Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury

    PubMed Central

    2011-01-01

    Mechanical ventilation (MV) has the potential to worsen pre-existing lung injury or even to initiate lung injury. Moreover, it is thought that injurious MV contributes to the overwhelming inflammatory response seen in patients with acute lung injury or acute respiratory distress syndrome. Ventilator-induced lung injury (VILI) is characterized by increased endothelial and epithelial permeability and pulmonary inflammation, in which the innate immune system plays a key role. A growing body of evidence indicates that endogenous danger molecules, also termed damage-associated molecular patterns (DAMPs), are released upon tissue injury and modulate the inflammatory response. DAMPs activate pattern recognition receptors, may induce the release of proinflammatory cytokines and chemokines, and have been shown to initiate or propagate inflammation in non-infectious conditions. Experimental and clinical studies demonstrate the presence of DAMPs in bronchoalveolar lavage fluid in patients with VILI and the upregulation of pattern recognition receptors in lung tissue by MV. The objective of the present article is to review research in the area of DAMPs, their recognition by the innate immune system, their role in VILI, and the potential utility of blocking DAMP signaling pathways to reduce VILI in the critically ill. PMID:22216838

  8. Nicotinamide Phosphoribosyltransferase Inhibitor Is a Novel Therapeutic Candidate in Murine Models of Inflammatory Lung Injury

    PubMed Central

    Moreno-Vinasco, Liliana; Quijada, Hector; Sammani, Saad; Siegler, Jessica; Letsiou, Eleftheria; Deaton, Ryan; Saadat, Laleh; Zaidi, Rafe S.; Messana, Joe; Gann, Peter H.; Machado, Roberto F.; Camp, Sara M.; Wang, Ting

    2014-01-01

    We previously identified the intracellular nicotinamide phosphoribosyltransferase (iNAMPT, aka pre–B-cell colony enhancing factor) as a candidate gene promoting acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) with circulating nicotinamide phosphoribosyltransferase potently inducing NF-κB signaling in lung endothelium. iNAMPT also synthesizes intracellular nicotinamide adenine dinucleotide (iNAD) in response to extracellular oxidative stress, contributing to the inhibition of apoptosis via ill-defined mechanisms. We now further define the role of iNAMPT activity in the pathogenesis of ARDS/VILI using the selective iNAMPT inhibitor FK-866. C57/B6 mice were exposed to VILI (40 ml/kg, 4 h) or LPS (1.5 mg/kg, 18 h) after osmotic pump delivery of FK-866 (100 mg/kg/d, intraperitoneally). Assessment of total bronchoalveolar lavage (BAL) protein, polymorphonuclear neutrophil (PMN) levels, cytokine levels (TNF-α, IL-6, IL-1α), lung iNAD levels, and injury scores revealed that FK-866–mediated iNAMPT inhibition successfully reduced lung tissue iNAD levels, BAL injury indices, inflammatory cell infiltration, and lung injury scores in LPS- and VILI-exposed mice. FK-866 further increased lung PMN apoptosis, as reflected by caspase-3 activation in BAL PMNs. These findings support iNAMPT inhibition via FK-866 as a novel therapeutic agent for ARDS via enhanced apoptosis in inflammatory PMNs. PMID:24588101

  9. The protective effect of dopamine on ventilator-induced lung injury via the inhibition of NLRP3 inflammasome.

    PubMed

    Yang, Xiaomei; Sun, Xiaotong; Chen, Hongli; Xi, Guangmin; Hou, Yonghao; Wu, Jianbo; Liu, Dejie; Wang, Huanliang; Hou, Yuedong; Yu, Jingui

    2017-04-01

    Dopamine (DA), a neurotransmitter, was previously shown to have anti-inflammatory effects. However, its role in ventilator-induced lung injury (VILI) has not been explicitly demonstrated. This study aimed to investigate the therapeutic efficacy and molecular mechanisms of dopamine in VILI. Rats were treated with dopamine during mechanical ventilation. Afterwards, the influence of dopamine on histological changes, pulmonary edema, the lung wet/dry (W/D) ratio, myeloperoxidase (MPO) activity, polymorphonuclear(PMN)counts, inflammatory cytokine levels, and NLRP3 inflammasome protein expression were examined. Our results showed that dopamine significantly attenuated lung tissue injury, the lung W/D ratio, MPO activity and neutrophil infiltration. Moreover, it inhibited inflammatory cytokine levels in the Bronchoalveolar lavage fluid (BAL). In addition, dopamine significantly inhibited ventilation-induced NLRP3 activation. Our experimental findings demonstrate that dopamine exerted protective effects in VILI by alleviating the inflammatory response through inhibition of NLRP3 signaling pathways. The present study indicated that dopamine could be a potential effective therapeutic strategy for the treatment of VILI. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Six-Month Evaluation of Extended Wear Soft Contact Lenses Among Armored Troops. Part 1. Clinical Findings

    DTIC Science & Technology

    1989-06-01

    Doctini Cou i Id s K.. ’rned A’ ’is TeSI I oumicroscorry onl asyr iptoirnac coritact-lens-wearing recruits Ar. I vili riili a I To a, QiiuviiridW ,’a...Optometry The University of Alabama, Birmingham Birmingham, AL 35294 About the Authors William G. Bachman received the Doctor of Op- tometry degree from

  11. Effect of Drag-Reducing Polymer Injection on the Lift and Drag of a Two- Dimensional Hydrofoil

    DTIC Science & Technology

    1974-09-01

    34 Johc I.. Huffma, Report 62-13, March 1962, 50 p. 21. "Technical Studies in Cargo Handling-Vili, Re-emination of Automated Ships," Raymond L. Erler and...Fleet Requirements, Raymond Erler , Report 63-8, February 1963, 23 p. 24. "Cargo Handling Research, A Ten-Year Progress Report," Staff, Report 63-4

  12. Endotoxin- and mechanical stress–induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter

    PubMed Central

    Elangovan, Venkateswaran Ramamoorthi; Camp, Sara M.; Kelly, Gabriel T.; Desai, Ankit A.; Adyshev, Djanybek; Sun, Xiaoguang; Black, Stephen M.; Wang, Ting

    2016-01-01

    Abstract Mechanical ventilation, a lifesaving intervention for patients with acute respiratory distress syndrome (ARDS), also unfortunately contributes to excessive mechanical stress and impaired lung physiological and structural integrity. We have elsewhere established the pivotal role of increased nicotinamide phosphoribosyltransferase (NAMPT) transcription and secretion as well as its direct binding to the toll-like receptor 4 (TLR4) in the progression of this devastating syndrome; however, regulation of this critical gene in ventilator-induced lung injury (VILI) is not well characterized. On the basis of an emerging role for epigenetics in enrichment of VILI and CpG sites within the NAMPT promoter and 5′UTR, we hypothesized that NAMPT expression and downstream transcriptional events are influenced by epigenetic mechanisms. Concomitantly, excessive mechanical stress of human pulmonary artery endothelial cells or lipopolysaccharide (LPS) treatment led to both reduced DNA methylation levels in the NAMPT promoter and increased gene transcription. Histone deacetylase inhibition by trichostatin A or Sirt-1–silencing RNA attenuates LPS-induced NAMPT expression. Furthermore, recombinant NAMPT administration induced TLR4-dependent global H3K9 hypoacetylation. These studies suggest a complex epigenetic regulatory network of NAMPT in VILI and ARDS and open novel strategies for combating VILI and ARDS. PMID:28090296

  13. Mechanical Power and Development of Ventilator-induced Lung Injury.

    PubMed

    Cressoni, Massimo; Gotti, Miriam; Chiurazzi, Chiara; Massari, Dario; Algieri, Ilaria; Amini, Martina; Cammaroto, Antonio; Brioni, Matteo; Montaruli, Claudia; Nikolla, Klodiana; Guanziroli, Mariateresa; Dondossola, Daniele; Gatti, Stefano; Valerio, Vincenza; Vergani, Giordano Luca; Pugni, Paola; Cadringher, Paolo; Gagliano, Nicoletta; Gattinoni, Luciano

    2016-05-01

    The ventilator works mechanically on the lung parenchyma. The authors set out to obtain the proof of concept that ventilator-induced lung injury (VILI) depends on the mechanical power applied to the lung. Mechanical power was defined as the function of transpulmonary pressure, tidal volume (TV), and respiratory rate. Three piglets were ventilated with a mechanical power known to be lethal (TV, 38 ml/kg; plateau pressure, 27 cm H2O; and respiratory rate, 15 breaths/min). Other groups (three piglets each) were ventilated with the same TV per kilogram and transpulmonary pressure but at the respiratory rates of 12, 9, 6, and 3 breaths/min. The authors identified a mechanical power threshold for VILI and did nine additional experiments at the respiratory rate of 35 breaths/min and mechanical power below (TV 11 ml/kg) and above (TV 22 ml/kg) the threshold. In the 15 experiments to detect the threshold for VILI, up to a mechanical power of approximately 12 J/min (respiratory rate, 9 breaths/min), the computed tomography scans showed mostly isolated densities, whereas at the mechanical power above approximately 12 J/min, all piglets developed whole-lung edema. In the nine confirmatory experiments, the five piglets ventilated above the power threshold developed VILI, but the four piglets ventilated below did not. By grouping all 24 piglets, the authors found a significant relationship between the mechanical power applied to the lung and the increase in lung weight (r = 0.41, P = 0.001) and lung elastance (r = 0.33, P < 0.01) and decrease in PaO2/FIO2 (r = 0.40, P < 0.001) at the end of the study. In piglets, VILI develops if a mechanical power threshold is exceeded.

  14. Cervical cancer screening in low-resource settings: a smartphone image application as an alternative to colposcopy.

    PubMed

    Gallay, Caroline; Girardet, Anne; Viviano, Manuela; Catarino, Rosa; Benski, Anne-Caroline; Tran, Phuong Lien; Ecabert, Christophe; Thiran, Jean-Philippe; Vassilakos, Pierre; Petignat, Patrick

    2017-01-01

    Visual inspection after application of acetic acid (VIA) and Lugol's iodine (VILI) is a cervical cancer (CC) screening approach that has recently been adopted in low- and middle-income countries (LMIC). Innovative technologies allow the acquisition of consecutive cervical images of VIA and VILI using a smartphone application. The aim of this study was to evaluate the quality of smartphone images in order to assess the feasibility and usability of a mobile application for CC screening in LMIC. Between May and November 2015, women aged 30-65 years were recruited in a CC screening campaign in Madagascar. Human papillomavirus-positive women were invited to undergo VIA/VILI assessment. Pictures of their cervix were taken using a Samsung Galaxy S5 with an application called "Exam", which was designed to obtain high-quality images and to classify them in the following sequence: native, VIA, VILI and posttreatment. Experts in colposcopy were asked to evaluate if the quality of the pictures was sufficient to establish the diagnosis and to assess sharpness, focus and zoom. The application use was simple and intuitive, and 208 pictures were automatically classified and recorded in the patient's file. The quality was judged as adequate for diagnosis in 93.3% of cases. The interobserver agreement was κ =0.45 (0.23-0.58), corresponding to a moderate agreement on the common scale of kappa values. This smartphone application allows the acquisition of good quality images for VIA/VILI diagnosis. The classification of images in a patient database makes them accessible to on- and off-site experts, and allows continuous clinical education. Smartphone applications may offer an alternative to colposcopy for CC screening in LMIC.

  15. Nitric oxide synthase 3 contributes to ventilator-induced lung injury

    PubMed Central

    Vaporidi, Katerina; Francis, Roland C.; Bloch, Kenneth D.

    2010-01-01

    Nitric oxide synthase (NOS) depletion or inhibition reduces ventilator-induced lung injury (VILI), but the responsible mechanisms remain incompletely defined. The aim of this study was to elucidate the role of endothelial NOS, NOS3, in the pathogenesis of VILI in an in vivo mouse model. Wild-type and NOS3-deficient mice were ventilated with high-tidal volume (HVT; 40 ml/kg) for 4 h, with and without adding NO to the inhaled gas. Additional wild-type mice were pretreated with tetrahydrobiopterin and ascorbic acid, agents that can prevent NOS-generated superoxide production. Arterial blood gas tensions, histology, and lung mechanics were evaluated after 4 h of HVT ventilation. The concentration of protein, IgM, cytokines, malondialdehyde, and 8-isoprostane were measured in bronchoalveolar lavage fluid (BALF). Myeloperoxidase activity, total and oxidized glutathione levels, and NOS-derived superoxide production were measured in lung tissue homogenates. HVT ventilation induced VILI in wild-type mice, as reflected by decreased lung compliance, increased concentrations of protein and cytokines in BALF, and oxidative stress. All indices of VILI were ameliorated in NOS3-deficient mice. Augmenting pulmonary NO levels by breathing NO during mechanical ventilation did not increase lung injury in NOS3-deficient mice. HVT ventilation increased NOS-inhibitable superoxide production in lung extracts from wild-type mice but not in those from NOS3-deficient mice. Administration of tetrahydrobiopterin and ascorbic acid ameliorated VILI in wild-type mice. Our results indicate that NOS3 contributes to ventilator-induced lung injury via increased production of superoxide. PMID:20453164

  16. Effects of sevoflurane on ventilator induced lung injury in a healthy lung experimental model.

    PubMed

    Romero, A; Moreno, A; García, J; Sánchez, C; Santos, M; García, J

    2016-01-01

    Ventilator-induced lung injury (VILI) causes a systemic inflammatory response in tissues, with an increase in IL-1, IL-6 and TNF-α in blood and tissues. Cytoprotective effects of sevoflurane in different experimental models are well known, and this protective effect can also be observed in VILI. The objective of this study was to assess the effects of sevoflurane in VILI. A prospective, randomized, controlled study was designed. Twenty female rats were studied. The animals were mechanically ventilated, without sevoflurane in the control group and sevoflurane 3% in the treated group (SEV group). VILI was induced applying a maximal inspiratory pressure of 35 cmH2O for 20 min without any positive end-expiratory pressure for 20 min (INJURY time). The animals were then ventilated 30 min with a maximal inspiratory pressure of 12 cmH2O and 3 cmH2O positive end-expiratory pressure (time 30 min POST-INJURY), at which time the animals were euthanized and pathological and biomarkers studies were performed. Heart rate, invasive blood pressure, pH, PaO2, and PaCO2 were recorded. The lung wet-to-dry weight ratio was used as an index of lung edema. No differences were found in the blood gas analysis parameters or heart rate between the 2 groups. Blood pressure was statistically higher in the control group, but still within the normal clinical range. The percentage of pulmonary edema and concentrations of TNF-α and IL-6 in lung tissue in the SEV group were lower than in the control group. Sevoflurane attenuates VILI in a previous healthy lung in an experimental subclinical model in rats. Copyright © 2015 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies

    PubMed Central

    Combescure, Christophe; Fokom-Defo, Victoire; Tebeu, Pierre Marie; Vassilakos, Pierre; Kengne, André Pascal; Petignat, Patrick

    2015-01-01

    Objective To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol’s iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. Design Systematic review and meta-analysis of diagnostic test accuracy studies. Data sources Systematic searches of multiple databases including Medline, Embase, and Scopus for studies published between January 1994 and June 2014. Review methods Inclusion criteria for studies were: alternative methods to cytology used as a standalone test for primary screening; study population not at particular risk of cervical cancer (excluding studies focusing on HIV positive women or women with gynaecological symptoms); women screened by nurses; reference test (colposcopy and directed biopsies) performed at least in women with positive screening results. Two reviewers independently screened studies for eligibility and extracted data for inclusion, and evaluated study quality using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) checklist. Primary outcomes were absolute accuracy measures (sensitivity and specificity) of screening tests to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Results 15 studies of moderate quality were included (n=61 381 for VIA, n=46 435 for VILI, n=11 322 for HPV testing). Prevalence of CIN2+ did not vary by screening test and ranged from 2.3% (95% confidence interval 1.5% to 3.3%) in VILI studies to 4.9% (2.7% to 7.8%) in HPV testing studies. Positivity rates of VILI, VIA, and HPV testing were 16.5% (9.8% to 24.7%), 16.8% (11.0% to 23.6%), and 25.8% (17.4% to 35.3%), respectively. Pooled sensitivity was higher for VILI (95.1%; 90.1% to 97.7%) than VIA (82.4%; 76.3% to 87.3%) in studies where the reference test was performed in all women (P<0.001). Pooled specificity of VILI and VIA were similar (87.2% (78.1% to 92.8%) v 87.4% (77.1% to 93

  18. Pulmonary atelectasis during low stretch ventilation: "open lung" versus "lung rest" strategy.

    PubMed

    Fanelli, Vito; Mascia, Luciana; Puntorieri, Valeria; Assenzio, Barbara; Elia, Vincenzo; Fornaro, Giancarlo; Martin, Erica L; Bosco, Martino; Delsedime, Luisa; Fiore, Tommaso; Grasso, Salvatore; Ranieri, V Marco

    2009-03-01

    Limiting tidal volume (VT) may minimize ventilator-induced lung injury (VILI). However, atelectasis induced by low VT ventilation may cause ultrastructural evidence of cell disruption. Apoptosis seems to be involved as protective mechanisms from VILI through the involvement of mitogen-activated protein kinases (MAPKs). We examined the hypothesis that atelectasis may influence the response to protective ventilation through MAPKs. Prospective randomized study. University animal laboratory. Adult male 129/Sv mice. Isolated, nonperfused lungs were randomized to VILI: VT of 20 mL/kg and positive end-expiratory pressure (PEEP) zero; low stretch/lung rest: VT of 6 mL/kg and 8-10 cm H2O of PEEP; low stretch/open lung: VT of 6 mL/kg, two recruitment maneuvers and 14-16 cm H2O of PEEP. Ventilator settings were adjusted using the stress index. Both low stretch strategies equally blunted the VILI-induced derangement of respiratory mechanics (static volume-pressure curve), lung histology (hematoxylin and eosin), and inflammatory mediators (interleukin-6, macrophage inflammatory protein-2 [enzyme-linked immunosorbent assay], and inhibitor of nuclear factor-kB[Western blot]). VILI caused nuclear swelling and membrane disruption of pulmonary cells (electron microscopy). Few pulmonary cells with chromatin condensation and fragmentation were seen during both low stretch strategies. However, although cell thickness during low stretch/open lung was uniform, low stretch/lung rest demonstrated thickening of epithelial cells and plasma membrane bleb formation. Compared with the low stretch/open lung, low stretch/lung rest caused a significant decrease in apoptotic cells (terminal deoxynucleotidyl transferase mediated deoxyuridine-triphosphatase nick end-labeling) and tissue expression of caspase-3 (Western blot). Both low stretch strategies attenuated the activation of MAPKs. Such reduction was larger during low stretch/open lung than during low stretch/lung rest (p < 0.001). Low stretch

  19. VEGF Production by Ly6C+high Monocytes Contributes to Ventilator-Induced Lung Injury

    PubMed Central

    Lin, Chin-Kuo; Li, Jhy-Ming; Chen, Mei-Hsin; Tsai, Mei-Ling; Chang, Chih-Ching

    2016-01-01

    Background Mechanical ventilation is a life-saving procedure for patients with acute respiratory failure, although it may cause pulmonary vascular inflammation and leakage, leading to ventilator-induced lung injury (VILI). Ly6C+high monocytes are involved in the pathogenesis of VILI. In this study, we investigated whether pulmonary infiltrated Ly6C+high monocytes produce vascular endothelial growth factor (VEGF) and contribute to VILI. Methods A clinically relevant two-hit mouse model of VILI, with intravenous lipopolysaccharide (LPS, 20 ng/mouse) immediately before high tidal volume (HTV, 20 mL/kg) ventilation (LPS+HTV), was established. Blood gas and respiratory mechanics were measured to ensure the development of VILI. Flow cytometry and histopathological analyses revealed pulmonary infiltration of leukocytes subsets. Clodronate liposomes were intravenously injected to deplete pulmonary monocytes. In vitro endothelial cell permeability assay with sorted Ly6C+high monocytes condition media assessed the role of Ly6C+high monocytes in vascular permeability. Results LPS+HTV significantly increased total proteins, TNF-α, IL-6, vascular endothelial growth factor (VEGF) and mononuclear cells in the bronchoalveolar lavage fluid (BALF). Pulmonary Ly6C+high monocytes (SSClowCD11b+F4/80+Ly6C+high), but not Ly6C+low monocytes (SSClowCD11b+F4/80+Ly6C+low), were significantly elevated starting at 4 hr. Clodronate liposomes were able to significantly reduce pulmonary Ly6C+high monocytes, and VEGF and total protein in BALF, and restore PaO2/FiO2. There was a strong correlation between pulmonary Ly6C+high monocytes and BALF VEGF (R2 = 0.8791, p<0.001). Moreover, sorted Ly6C+high monocytes were able to produce VEGF, resulting in an increased permeability of endothelial cell monolayer in an in vitro endothelial cell permeability assay. Conclusion VEGF produced by pulmonary infiltrated Ly6C+high monocytes regulates vasculature permeability in a two-hit model of HTV-induced lung

  20. Cervical cancer screening in a low-resource setting: a pilot study on an HPV-based screen-and-treat approach.

    PubMed

    Kunckler, Margot; Schumacher, Fanny; Kenfack, Bruno; Catarino, Rosa; Viviano, Manuela; Tincho, Eveline; Tebeu, Pierre-Marie; Temogne, Liliane; Vassilakos, Pierre; Petignat, Patrick

    2017-07-01

    Cervical cancer (CC) is the leading cause of cancer-related death among women in sub-Saharan Africa, primarily because of limited access to effective screening and preventive treatment. Our aim was to assess the feasibility of a human papillomavirus (HPV)-based CC screen-and-treat approach in a low-resource context. We recruited 1012 women aged 30-49 years through a CC screening campaign conducted in the District Hospital of Dschang, Cameroon. Participants performed HPV self-sampling, which was tested for high-risk HPV (HR-HPV) DNA using the point-of-care Xpert HPV assay. All HPV-positive women were invited for visual inspection with acetic acid and Lugol's iodine (VIA/VILI) to exclude CC or enable triage. A cervical sample for histological analysis was also collected. Women positive for HPV 16/18/45 and for other HR-HPV with pathological VIA/VILI were selected to undergo treatment with thermocoagulation. The HPV prevalence in the study population was 18.5% (n = 187); of these cases, 20 (10.6%), 42 (22.3%) and 140 (74.9%) were positive for HPV16, HPV18/45 and other HR-HPV types, respectively. Overall, 107/185 (57.8%) VIA/VILI examinations were classified as pathological and 78 (42.2%) as normal. Women positive for HPV16/18/45 were 4.2 times more likely to harbor cervical intraepithelial neoplasia grade 2 or worse (CIN2+) than those with other HPV types. The specificity of HPV 16/18/45 genotypes for detection of high-grade lesions among HR-HPV positive women was higher than that of VIA/VILI in all age groups. The sensitivity and specificity of VIA/VILI in detecting CIN2+ among HPV positive women were 80% and 44%, respectively. Overall, 110/121 screen-positive women (90.9%) were eligible for, and were treated with, thermocoagulation. An HPV-based screen-and-treat approach is feasible in a low-resource context and may contribute to improving the effectiveness of CC prevention programs. Immediate thermocoagulation treatment for women who are HPV16- and/or HPV18

  1. Calculations of multiquark functions in effective models of strong interaction

    SciTech Connect

    Jafarov, R. G.; Rochev, V. E.

    2013-09-15

    In this paper we present our results of the investigation of multiquark equations in the Nambu-Jona-Lasinio model with chiral symmetry of SU(2) group in the mean-field expansion. To formulate the mean-field expansion we have used an iteration scheme of solution of the Schwinger-Dyson equations with the fermion bilocal source. We have considered the equations for Green functions of the Nambu-Jona-Lasinio model up to third step for this iteration scheme. To calculate the high-order corrections to the mean-field approximation, we propose the method of the Legendre transformation with respect to the bilocal source, which allows effectively to take into account the symmetry constraints related with the chiral Ward identity. We discuss also the problem of calculating the multiquark functions in the mean-field expansion for Nambu-Jona-Lasinio-type models with other types of the multifermion sources.

  2. Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury.

    PubMed

    Hayes, Mairead; Curley, Gerard F; Masterson, Claire; Devaney, James; O'Toole, Daniel; Laffey, John G

    2015-12-01

    The potential for mesenchymal stem cells (MSCs) to reduce the severity of experimental lung injury has been established in several pre-clinical studies. We have recently demonstrated that MSCs, and MSC-secreted factors (secretome), enhance lung repair and regeneration at 48 h following ventilation-induced lung injury (VILI). We wished to determine the potential for MSC therapy to exert beneficial effects in the early recovery phase following VILI when ongoing injury coexists with processes of repair, and to compare the efficacy of MSC therapy to the use of the secretome alone. Male Sprague-Dawley rats were anesthetized, oro-tracheally intubated, and subjected to high stretch mechanical ventilation until lung compliance had declined by 50 % of baseline. Animals were then weaned from mechanical ventilation, and anesthesia discontinued. Once awake and spontaneously ventilating, animals received an intravenous injection of either rodent MSCs (10 million/kg), MSC-conditioned medium, fibroblasts (10 million/kg), or vehicle. Thereafter, the animals were allowed to recover and the extent of lung injury/repair was determined after 4 h. Treatment with MSCs diminished injury and enhanced recovery following VILI to a greater extent compared to MSC-conditioned medium, with fibroblasts proving ineffective. MSCs, but not their conditioned medium, attenuated indices of lung injury including oxygenation, respiratory compliance, and lung edema. Total lung water as assessed by wet:dry ratio, bronchoalveolar lavage total inflammatory cell, neutrophil counts, and alveolar IL-6 concentrations were reduced in the animals that received MSC therapy. The immunomodulating and/or reparative effect of MSCs is evident early after VILI in this model. MSC-conditioned medium was not as effective as the cells themselves in diminishing injury and restoring lung structure and function.

  3. The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Szabari, Margit V.; Miller, Alyssa J.; Hariri, Lida P.; Hamblin, Michael R.; Musch, Guido; Stroh, Helene; Suter, Melissa J.

    2016-03-01

    Although mechanical ventilation (MV) is necessary to support gas exchange in critically ill patients, it can contribute to the development of lung injury and multiple organ dysfunction. It is known that high tidal volume (Vt) MV can cause ventilator-induced lung injury (VILI) in healthy lungs and increase the mortality of patients with Acute Respiratory Distress Syndrome. Low level laser therapy (LLLT) has demonstrated to have anti-inflammatory effects. We investigated whether LLLT could alleviate inflammation from injurious MV in mice. Adult mice were assigned to 2 groups: VILI+LLLT group (3 h of injurious MV: Vt=25-30 ml/kg, respiratory rate (RR)=50/min, positive end-expiratory pressure (PEEP)=0 cmH20, followed by 3 h of protective MV: Vt=9 ml/kg, RR=140/min, PEEP=2 cmH20) and VILI+no LLLT group. LLLT was applied during the first 30 min of the MV (810 nm LED system, 5 J/cm2, 1 cm above the chest). Respiratory impedance was measured in vivo with forced oscillation technique and lung mechanics were calculated by fitting the constant phase model. At the end of the MV, bronchoalveolar lavage (BAL) was performed and inflammatory cells counted. Lungs were removed en-bloc and fixed for histological evaluation. We hypothesize that LLLT can reduce lung injury and inflammation from VILI. This therapy could be translated into clinical practice, where it can potentially improve outcomes in patients requiring mechanical ventilation in the operating room or in the intensive care units.

  4. Development of X-Ray Laser Media. Measurement of Gain and Development of Cavity Resonators for Wavelengths near 130 Angstroms. Volume 3.

    DTIC Science & Technology

    1983-02-01

    increasing need far a awe precise uderstanding of their reflecting properties. Thus, 9 ct that in the future more detailed modeling vili be... modeling of these more ozplex structures. One such structure that may be of interest is that of a multilayer degraded by interfacial roughness. ib d...this effect, we attempt in sec. 11-6 to model the complex ISRM process. We refer to the residual kind of thickness error that can occur in such

  5. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

    SciTech Connect

    Huang, Chien-Sheng; Kawamura, Tomohiro; Peng, Ximei; Tochigi, Naobumi; Shigemura, Norihisa; Billiar, Timothy R.; Nakao, Atsunori; Toyoda, Yoshiya

    2011-05-06

    Highlights: {yields} Hydrogen is a regulatory molecule with antiinflammatory and antiapoptotic protective effects. {yields} There is very limited information on the pathways regulated in vivo by the hydrogen. {yields} Antiapoptotic abilities of hydrogen were explained by upregulation of the antiapoptotic gene. {yields} NF{kappa}B activation during hydrogen treatment was correlated with elevated antiapoptotic protein. {yields} NF{kappa}B activation associated with increase Bcl-2 may contribute to cytoprotection of hydrogen. -- Abstract: We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NF{kappa}B) signaling pathway. VILI was generated in male C57BL6 mice by performing a tracheostomy and placing the mice on a mechanical ventilator (tidal volume of 30 ml/kg or 10 ml/kg without positive end-expiratory pressure). The ventilator delivered either 2% nitrogen or 2% hydrogen in balanced air. NF{kappa}B activation, as indicated by NF{kappa}B DNA binding, was detected by electrophoretic mobility shift assays and enzyme-linked immunosorbent assay. Hydrogen gas inhalation increased NF{kappa}B DNA binding after 1 h of ventilation and decreased NF{kappa}B DNA binding after 2 h of ventilation, as compared with controls. The early activation of NF{kappa}B during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax. Hydrogen inhalation increased oxygen tension, decreased lung edema, and decreased the expression of proinflammatory mediators. Chemical inhibition of early NF{kappa}B activation using SN50 reversed these protective effects. NF{kappa}B activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the

  6. Web-based instrument to assess skills in visual inspection of the cervix among healthcare providers.

    PubMed

    Negulescu, Raluca-Anca; Catarino, Rosa; De Vuyst, Hugo; Undurraga-Malinverno, Manuela; Meyer-Hamme, Ulrike; Alec, Milena; Campana, Aldo; Vassilakos, Pierre; Petignat, Patrick

    2016-07-01

    To validate a web-based instrument for assessing healthcare providers' skills in visual inspection with acetic acid or Lugol iodine (VIA/VILI) for the diagnosis and management of cervical intraepithelial neoplasia. An observational cross-sectional study enrolled healthcare providers in a web-based assessment of VIA/VILI skills between August and November 2014. Participants participated in a four-module training course, followed by a multiple-choice test with 70 questions based on cervical photographs of HPV-positive women participating in cervical screening. Logistic regression was used to identify relationships between independent variables and success on the test. Overall, 255 participants completed the test and 99 (38.8%) passed. No correlation was found between age or sex and test performance. Compared with other healthcare workers, physicians (odds ratio [OR] 1.91, 95% confidence interval [CI] 1.01-3.63; P=0.048), and participants with more colposcopy experience (OR 3.62, 95% CI 1.91-6.85; P<0.001) and postgraduate VIA/VILI training (OR 1.95, 95% CI 1.16-3.29; P=0.012) were more likely to pass the test. Participants who repeated the test (31/255 [12.2%]) were five times more likely to succeed on their second repeat (OR 5.89, 95% CI 1.46-23.73; P=0.013). Web-based training for VIA/VILI is feasible and can identify healthcare workers who are proficient in this technique. Copyright © 2016 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  7. Passive Seismic Artillery Location by Exact Inverse Scattering,

    DTIC Science & Technology

    1980-07-01

    DOMAIN A VI NUMERICO -EXPERIMENTAL RESULTS 11 VII RECORIMENDATIONS FOR FUTURE RESEARCH 17 VIlI REFERENCES 19 IX APPENDIX: EXACT INVERSE SCATTERING THEORY...these numerico -experimental results, recomnendations for future research are made in section VII. A_ I I SECTION II REFORMULATION OF THE RAYLEIGH...N00014-76-C-0082) in the latter part of this research. This solution was numerico -experimentally verified for a point source and 11 I a point source

  8. Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9.

    PubMed

    Blázquez-Prieto, Jorge; López-Alonso, Inés; Amado-Rodríguez, Laura; Huidobro, Covadonga; González-López, Adrián; Kuebler, Wolfgang M; Albaiceta, Guillermo M

    2017-09-25

    Neutrophils may cause tissue disruption during migration and by releasing cytotoxic molecules. However, the benefits of neutrophil depletion observed in experimental models of lung injury do not correspond with the poor outcome of neutropenic patients. To clarify the role of neutrophils during repair, mice with ventilator induced lung injury (VILI) were rendered neutropenic after damage, and followed for 48 hours of spontaneous breathing. Lungs were harvested and inflammatory mediators and matrix metalloproteinases measured. Bronchoalveolar lavage fluid (BALF) from ventilated patients with acute respiratory distress syndrome, with or without neutropenia, was collected, the same mediators measured and their effects in an ex vivo model of alveolar repair studied. Finally, neutropenic mice were treated after VILI with exogenous matrix metalloproteinase-9 (MMP-9). Lungs from neutropenic animals showed delayed repair and displayed higher levels of tumour necrosis factor α, interferon γ and macrophage inflammatory protein 2, and absence of MMP-9. BALF from ventilated neutropenic patients with acute respiratory distress syndrome showed similar results. BALFs from neutropenic patients yielded a delayed closure rate of epithelial wounds ex vivo, which was improved by removal of collagen or addition of exogenous MMP-9. Lastly, treatment of neutropenic mice with exogenous MMP-9 after VILI reduced tissue damage without modifying cytokine concentrations. Release of MMP-9 from neutrophils is required for adequate matrix processing and lung repair. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. High Bias Gas Flows Increase Lung Injury in the Ventilated Preterm Lamb

    PubMed Central

    Bach, Katinka P.; Kuschel, Carl A.; Hooper, Stuart B.; Bertram, Jean; McKnight, Sue; Peachey, Shirley E.; Zahra, Valerie A.; Flecknoe, Sharon J.; Oliver, Mark H.; Wallace, Megan J.; Bloomfield, Frank H.

    2012-01-01

    Background Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI), leading to the development of bronchopulmonary dysplasia (BPD). It is not known whether shear stress injury from gases flowing into the preterm lung during ventilation contributes to VILI. Methods Preterm lambs of 131 days’ gestation (term = 147 d) were ventilated for 2 hours with a bias gas flow of 8 L/min (n = 13), 18 L/min (n = 12) or 28 L/min (n = 14). Physiological parameters were measured continuously and lung injury was assessed by measuring mRNA expression of early injury response genes and by histological analysis. Control lung tissue was collected from unventilated age-matched fetuses. Data were analysed by ANOVA with a Tukey post-hoc test when appropriate. Results High bias gas flows resulted in higher ventilator pressures, shorter inflation times and decreased ventilator efficiency. The rate of rise of inspiratory gas flow was greatest, and pulmonary mRNA levels of the injury markers, EGR1 and CTGF, were highest in lambs ventilated with bias gas flows of 18 L/min. High bias gas flows resulted in increased cellular proliferation and abnormal deposition of elastin, collagen and myofibroblasts in the lung. Conclusions High ventilator bias gas flows resulted in increased lung injury, with up-regulation of acute early response genes and increased histological lung injury. Bias gas flows may, therefore, contribute to VILI and BPD. PMID:23056572

  10. Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

    PubMed Central

    Camp, Sara M.; Ceco, Ermelinda; Evenoski, Carrie L.; Danilov, Sergei M.; Zhou, Tong; Chiang, Eddie T.; Moreno-Vinasco, Liliana; Mapes, Brandon; Zhao, Jieling; Gursoy, Gamze; Brown, Mary E.; Adyshev, Djanybek M.; Siddiqui, Shahid S.; Quijada, Hector; Sammani, Saad; Letsiou, Eleftheria; Saadat, Laleh; Yousef, Mohammed; Wang, Ting; Liang, Jie; Garcia, Joe G. N.

    2015-01-01

    Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/PBEF). Although VILI severity is attenuated by reduced NAMPT/PBEF bioavailability, the precise contribution of NAMPT/PBEF and excessive mechanical stress to VILI pathobiology is unknown. We now report that NAMPT/PBEF induces lung NFκB transcriptional activities and inflammatory injury via direct ligation of Toll–like receptor 4 (TLR4). Computational analysis demonstrated that NAMPT/PBEF and MD-2, a TLR4-binding protein essential for LPS-induced TLR4 activation, share ~30% sequence identity and exhibit striking structural similarity in loop regions critical for MD-2-TLR4 binding. Unlike MD-2, whose TLR4 binding alone is insufficient to initiate TLR4 signaling, NAMPT/PBEF alone produces robust TLR4 activation, likely via a protruding region of NAMPT/PBEF (S402-N412) with structural similarity to LPS. The identification of this unique mode of TLR4 activation by NAMPT/PBEF advances the understanding of innate immunity responses as well as the untoward events associated with mechanical stress-induced lung inflammation. PMID:26272519

  11. Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

    PubMed

    Rizzo, Alicia N; Sammani, Saad; Esquinca, Adilene E; Jacobson, Jeffrey R; Garcia, Joe G N; Letsiou, Eleftheria; Dudek, Steven M

    2015-12-01

    Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), an illness characterized by life-threatening vascular leak, is a significant cause of morbidity and mortality in critically ill patients. Recent preclinical studies and clinical observations have suggested a potential role for the chemotherapeutic agent imatinib in restoring vascular integrity. Our prior work demonstrates differential effects of imatinib in mouse models of ALI, namely attenuation of LPS-induced lung injury but exacerbation of ventilator-induced lung injury (VILI). Because of the critical role of mechanical ventilation in the care of patients with ARDS, in the present study we pursued an assessment of the effectiveness of imatinib in a "two-hit" model of ALI caused by combined LPS and VILI. Imatinib significantly decreased bronchoalveolar lavage protein, total cells, neutrophils, and TNF-α levels in mice exposed to LPS plus VILI, indicating that it attenuates ALI in this clinically relevant model. In subsequent experiments focusing on its protective role in LPS-induced lung injury, imatinib attenuated ALI when given 4 h after LPS, suggesting potential therapeutic effectiveness when given after the onset of injury. Mechanistic studies in mouse lung tissue and human lung endothelial cells revealed that imatinib inhibits LPS-induced NF-κB expression and activation. Overall, these results further characterize the therapeutic potential of imatinib against inflammatory vascular leak.

  12. Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury.

    PubMed

    Seah, Adrian S; Grant, Kara A; Aliyeva, Minara; Allen, Gilman B; Bates, Jason H T

    2011-05-01

    Management of patients with acute lung injury (ALI) rests on achieving a balance between the gas exchanging benefits of mechanical ventilation and the exacerbation of tissue damage in the form of ventilator-induced lung injury (VILI). Optimizing this balance requires an injury cost function relating injury progression to the measurable pressures, flows, and volumes delivered during mechanical ventilation. With this in mind, we mechanically ventilated naive, anesthetized, paralyzed mice for 4 h using either a low or high tidal volume (Vt) with either moderate or zero positive end-expiratory pressure (PEEP). The derecruitability of the lung was assessed every 15 min in terms of the degree of increase in lung elastance occurring over 3 min following a recruitment maneuver. Mice could be safely ventilated for 4 h with either a high Vt or zero PEEP, but when both conditions were applied simultaneously the lung became increasingly unstable, demonstrating worsening injury. We were able to mimic these data using a computational model of dynamic recruitment and derecruitment that simulates the effects of progressively increasing surface tension at the air-liquid interface, suggesting that the VILI in our animal model progressed via a vicious cycle of alveolar leak, degradation of surfactant function, and increasing tissue stress. We thus propose that the task of ventilating the injured lung is usefully understood in terms of the Vt-PEEP plane. Within this plane, non-injurious combinations of Vt and PEEP lie within a "safe region", the boundaries of which shrink as VILI develops.

  13. Cervical Cancer Screening Program by Visual Inspection: Acceptability and Feasibility in Health Insurance Companies

    PubMed Central

    Horo, Apollinaire G.; Didi-Kouko Coulibaly, Judith; Koffi, Abdoul; Tchounga, Boris; Seni, Konan; Aka, Kacou Edèle; Kone, Mamourou

    2015-01-01

    Objective. To assess willingness to participate and diagnostic accuracy of visual inspection for early detection of cervical neoplasia among women in a health insurance company. Patients and Method. Cervical cancer screening was systematically proposed to 800 women after consecutive information and awareness sessions. The screening method was visual inspection with acetic acid (VIA) or Lugol's iodine (VILI). Results. Among the 800 identified women, 640 (82%) have accepted the screening, their mean age was 39 years, and 12.0% of them were involved in a polygamist couple. 28.2% of women had prior cervical screening. VIA has been detected positive in 5.9% of women versus 8.6% for VILI. The sensitivity was 72.9% and specificity was 95.2% for VIA versus 71.2% and 97.3% for VILI respectively. The histological examination highlighted a nonspecific chronic cervicitis in 4.6%, CIN1 lesions in 5.91%, and CIN2/3 in 1.2% of the cases. Conclusion. Cervical cancer screening by visual inspection showed appropriate diagnostic accuracy when used to detect early cervical lesions. It is a simple and easy to perform method that could be introduced progressively in the health insurance policy while waiting for a national screening program. PMID:26167178

  14. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury

    PubMed Central

    Spassov, Sashko Georgiev; Donus, Rosa; Ihle, Paul Mikael; Engelstaedter, Helen; Hoetzel, Alexander

    2017-01-01

    The development of ventilator-induced lung injury (VILI) is still a major problem in mechanically ventilated patients. Low dose inhalation of hydrogen sulfide (H2S) during mechanical ventilation has been proven to prevent lung damage by limiting inflammatory responses in rodent models. However, the capacity of H2S to affect oxidative processes in VILI and its underlying molecular signaling pathways remains elusive. In the present study we show that ventilation with moderate tidal volumes of 12 ml/kg for 6 h led to an excessive formation of reactive oxygen species (ROS) in mice lungs which was prevented by supplemental inhalation of 80 parts per million of H2S. In addition, phosphorylation of the signaling protein Akt was induced by H2S. In contrast, inhibition of Akt by LY294002 during ventilation reestablished lung damage, neutrophil influx, and proinflammatory cytokine release despite the presence of H2S. Moreover, the ability of H2S to induce the antioxidant glutathione and to prevent ROS production was reversed in the presence of the Akt inhibitor. Here, we provide the first evidence that H2S-mediated Akt activation is a key step in protection against VILI, suggesting that Akt signaling limits not only inflammatory but also detrimental oxidative processes that promote the development of lung injury. PMID:28250891

  15. Cockroach fauna in the Ogasawara Chain Islands of Japan and analysis of their habitats.

    PubMed

    Komatsu, Noriyuki; Kishimoto, Toshio; Uchida, Akihiko; Ooi, Hong-Kean

    2013-03-01

    A survey of cockroach fauna was carried out on the 3 inhabited islands of the Ogasawara chain island of Japan, namely, Chichijima island, Hahajima island and Iwo island. Seven species, namely, Periplaneta americana (Linnaeus, 1758), Periplaneta australasiae (Fabricius, 1775), Blattella lituricollis (Walker, 1868), Onychostylus vilis (Brunner von Wattenwyl, 1865), Supella longipalpa (Fabricius, 1798), Pycnoscelus surinamensis (Linnaeus, 1758) and Opisthoplatia orientalis (Burmeister, 1838), were collected on Chichijima island. Four species, namely, P. americana, P. australasiae, O. vilis and P. surinamensis were collected on Hahajima island and 6 species, namely, P. americana, P. australasiae, B. lituricollis, O. vilis, P. surinamensis and Neostylopyga rhombifolia were collected on Iwo island. This is the first record of N. rhombifolia and Onychostylus orientalis on the Ogasawara chain islands. Our study increases the recorded taxon of cockroaches on the Ogasawara from 3 families, 5 genera 10 species to 4 families, 7 genera, 12 species. A list of the cockroach species on Ogasawara islands reported to date as well as a key for their identification is also presented. Periplaneta americana and P. australasiae, being the dominant species, together with S. longipalpa, were collected mostly in the indoor environment, indicating their preference for this habitat. Pycnoscelus surinamensis, which is considered as an outdoor insect has been found in semi-household environments such as greenhouse and shed, indicating their new adaptation to the changing environment.

  16. Activation of the Wnt/β-Catenin Signaling Pathway by Mechanical Ventilation Is Associated with Ventilator-Induced Pulmonary Fibrosis in Healthy Lungs

    PubMed Central

    Valladares, Francisco; Casula, Milena; Flores, Carlos; Blanch, Lluís; Quilez, María Elisa; Santana-Rodríguez, Norberto; Kacmarek, Robert M.; Slutsky, Arthur S.

    2011-01-01

    Background Mechanical ventilation (MV) with high tidal volumes (VT) can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI). The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI. Methodology/Principal Findings Prospective, randomized, controlled animal study using adult, healthy, male Sprague-Dawley rats. Animals (n = 6/group) were randomized to spontaneous breathing or two strategies of MV for 4 hours: low tidal volume (VT) (6 mL/kg) or high VT (20 mL/kg). Histological evaluation of lung tissue, measurements of WNT5A, total β-catenin, non-phospho (Ser33/37/Thr41) β-catenin, matrix metalloproteinase-7 (MMP-7), cyclin D1, vascular endothelial growth factor (VEGF), and axis inhibition protein 2 (AXIN2) protein levels by Western blot, and WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, and AXIN2 immunohistochemical localization in the lungs were analyzed. High-VT MV caused lung inflammation and perivascular edema with cellular infiltrates and collagen deposition. Protein levels of WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 in the lungs were increased in all ventilated animals although high-VT MV was associated with significantly higher levels of WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 levels. Conclusions/Significance Our findings demonstrate that the Wnt/β-catenin signaling pathway is modulated very early by MV in lungs without preexistent lung disease, suggesting that activation of this pathway could play an important role in both VILI and lung repair. Modulation of this pathway might represent a therapeutic option for prevention and/or management of VILI. PMID:21935365

  17. Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.

    PubMed

    Villar, Jesús; Cabrera, Nuria E; Valladares, Francisco; Casula, Milena; Flores, Carlos; Blanch, Lluís; Quilez, María Elisa; Santana-Rodríguez, Norberto; Kacmarek, Robert M; Slutsky, Arthur S

    2011-01-01

    Mechanical ventilation (MV) with high tidal volumes (V(T)) can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI). The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI. Prospective, randomized, controlled animal study using adult, healthy, male Sprague-Dawley rats. Animals (n = 6/group) were randomized to spontaneous breathing or two strategies of MV for 4 hours: low tidal volume (V(T)) (6 mL/kg) or high V(T) (20 mL/kg). Histological evaluation of lung tissue, measurements of WNT5A, total β-catenin, non-phospho (Ser33/37/Thr41) β-catenin, matrix metalloproteinase-7 (MMP-7), cyclin D1, vascular endothelial growth factor (VEGF), and axis inhibition protein 2 (AXIN2) protein levels by Western blot, and WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, and AXIN2 immunohistochemical localization in the lungs were analyzed. High-V(T) MV caused lung inflammation and perivascular edema with cellular infiltrates and collagen deposition. Protein levels of WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 in the lungs were increased in all ventilated animals although high-V(T) MV was associated with significantly higher levels of WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, MMP-7, cyclin D1, VEGF, and AXIN2 levels. Our findings demonstrate that the Wnt/β-catenin signaling pathway is modulated very early by MV in lungs without preexistent lung disease, suggesting that activation of this pathway could play an important role in both VILI and lung repair. Modulation of this pathway might represent a therapeutic option for prevention and/or management of VILI.

  18. A Unified Theory of Penetration

    DTIC Science & Technology

    1986-12-01

    in High-velocity Impact Phenomena, Ed. by R. Kinslow (New York, Academic F. ess, 1970). 3.7 J. S. Rinehart and J. Pearson, Behavior of Metals under...Rosset L. Magness A. Dietrich J. Zook G. Moss R. Frey H. Jonas W. Bruchey J. Zukas "G. Hauver K. Frank T. Wright G. Silsby A. Finnerty A. Kurian J. Polk

  19. Proceedings of the 1990 Annual Meeting of the Association for Education in Journalism and Mass Communication (73rd, Minneapolis, Minnesota, August 1-4, 1990). Part VI: Foreign and International Media Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The foreign and international media studies section of the proceedings includes the following 11 papers: "The Contemporary Pacific Islands Press" (Suzanna Layton); "Cultural Domination and Sovereignty: The Development of European TV Quotas, 1981-89" (Ulf Jonas Bjork); "A Content Analysis of TV News in Saudi Arabia and…

  20. Three Misunderstandings of Plato's Theory of Moral Education

    ERIC Educational Resources Information Center

    Jonas, Mark E.

    2016-01-01

    In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative…

  1. Aspects of the strongly interacting matter phase diagram within non-local quark models

    SciTech Connect

    Pagura, V.; Dumm, D. G.; Scoccola, N. N.

    2013-03-25

    We study a nonlocal extension of the so-called Polyakov Nambu-Jona-Lasinio model at finite temperature and chemical potential, considering the impact of the presence of dynamical quarks on the scale parameter appearing in the Polyakov potential. Both real and imaginary chemical potentials are considered. The effect of varying the current quark mass is also investigated.

  2. Making Lipid Membranes Rough, Tough, and Ready to Hit the Road

    DTIC Science & Technology

    2006-07-01

    come into contact with the surface with long-term use. Besides biofouling, solid- supported bilayers can be easily ruined when contaminated with common ...Baumgart, U. Jonas, A. Offenhäusser, and W. Knoll, Langmuir 18 (2002) p. 4082. 30. T. Petralli- Mallow , K.A. Brigmann, L.J. Richter, J.C. Stephenson

  3. A User-Centered Approach to the Design of an Expert System for Training.

    ERIC Educational Resources Information Center

    Borges, Marcos Augusto Francisco; Baranauskas, M. Cecilia C.

    1998-01-01

    Reports on a research project designed to develop an intelligent computer-based learning environment of industrial applications. "Jonas," an expert system, is part of a modeling/simulation environment which enables shop-floor workers to test and put new philosophies of work into practice in the context of manufacture. The approach focuses on the…

  4. Ben Jonson: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Barish, Jonas A., Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Jonas A. Barish, T. S. Eliot, L. C. Knights, Harry Levin, Edmund Wilson, Arthur Sale, C. H. Herford, Paul Goodman, Edward B. Partridge, Ray L. Heffner, Jr., Joseph Allen Bryant, Jr., and Dolora Cunningham--all dealing…

  5. Toward a Communication Theory Focused on Humankind's Future.

    ERIC Educational Resources Information Center

    Ternent, William A.; Ternent, Janet A.

    This speech presents a model of human communication which integrates the existential philosophy of Martin Buber with the communication views of Jonas Salk. In his book, "The Survival of the Wisest," Salk characterizes an "Epoch A" to describe the values and behaviors of the past and an "Epoch B" to describe the necessary values and behaviors for…

  6. Earth observation taken by the Expedition 46 crew

    NASA Image and Video Library

    2016-01-24

    ISS046e022766 (01/24/2016) --- NASA astronaut Scott Kelly captured this sunrise over Earth and tweeted this message: " blizzard2016 clearly seen off the #EastCoast as the sun begins to rise. Hope all OK! #BlizzardJonas #YearInSpace".

  7. How Can Video Supported Reflection Enhance Teachers' Professional Development?

    ERIC Educational Resources Information Center

    McCullagh, John F.

    2012-01-01

    This paper responds to Eva Lundqvist, Jonas Almqvist and Leif Ostman's account of how the manner of teaching can strongly influence pupil learning by recommending video supported reflection as a means by which teachers can transform the nature of their practice. Given the complex nature of the many conditions which influence and control teachers'…

  8. Precision Control and Randomized Benchmarking of a 12-us Class Superconducting Qubit

    DTIC Science & Technology

    2013-03-28

    2012 2.00 David Cory, Jonas Bylander, Fei Yan, Simon Gustavsson, Fumiki Yoshihara, Khalil Harrabi, Terry Orlando, Yasunobu Nakamura, Jaw-Shen Tsai...spectroscopy through dynamical decoupling with a superconducting flux qubit” viii. Seminar: Chalmers University of Technology, Gothenburg, Sweden, September

  9. NIH MedlinePlus the Magazine: Health, Medical & Wellness Articles

    MedlinePlus

    ... ve handled their health challenges. Sometimes it's the famous, like Nick Jonas, Randy Jackson or Mary Tyler Moore. But mostly, it's regular people who have turned to NIH for care and want to share their stories. Often, too, NIH scientists will write about their efforts to cure disease. ...

  10. Proceedings of the 1990 Annual Meeting of the Association for Education in Journalism and Mass Communication (73rd, Minneapolis, Minnesota, August 1-4, 1990). Part VI: Foreign and International Media Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The foreign and international media studies section of the proceedings includes the following 11 papers: "The Contemporary Pacific Islands Press" (Suzanna Layton); "Cultural Domination and Sovereignty: The Development of European TV Quotas, 1981-89" (Ulf Jonas Bjork); "A Content Analysis of TV News in Saudi Arabia and…

  11. The Earth Science Unmanned Aerial System (UAS) Demonstration in the Rover Scape at NASA's Ames Research Center.

    NASA Image and Video Library

    2016-09-30

    Flight Test in the Roverscape (N-269) at NASA's Ames Research Center, the project team tests the DJI Matrice 600 Unmanned Aerial Vehicle (UAV) equipped with a radio tracking receiver to study the invasive asian carp in the Mississippi River. Rick, Kolyer, Jonas Jonsson, Ethan, Pinsker, Bob Dahlgren.

  12. Salk therapy begins.

    PubMed

    1996-01-01

    A clinical trial to test an immune therapy developed by polio pioneer Jonas Salk has begun enrollment of 3,000 participants, who will receive Remune shots every 12 weeks for 3 years to see if disease progression is slowed. The manufacturer is Immune Response, and the study is being conducted by the University of California at San Francisco.

  13. Toward a Communication Theory Focused on Humankind's Future.

    ERIC Educational Resources Information Center

    Ternent, William A.; Ternent, Janet A.

    This speech presents a model of human communication which integrates the existential philosophy of Martin Buber with the communication views of Jonas Salk. In his book, "The Survival of the Wisest," Salk characterizes an "Epoch A" to describe the values and behaviors of the past and an "Epoch B" to describe the necessary values and behaviors for…

  14. Response of nucleons to external probes in hedgehog models. I. Electromagnetic polarizabilities

    SciTech Connect

    Broniowski, W.; Cohen, T.D. )

    1993-01-01

    Electromagnetic polarizabilities of the nucleon are analyzed in a hedgehog model with quark and meson degrees of freedom. Semiclassical methods are used (linear response theory, quantization via cranking). It is found that in hedgehog models (Skyrmion, chiral quark models, Nambu--Jona-Lasinio model), the average electric polarizability of the nucleon, [alpha][sub [ital N

  15. Foundational Studies in Teacher Education: A Reexamination. Special Issues from the Teachers College Record.

    ERIC Educational Resources Information Center

    Tozer, Steven, Ed.; Anderson, Thomas H., Ed.; Armbruster, Bonnie B., Ed.

    This collection of essays focuses on the role of psychological and cultural foundations in teacher education. Following an introduction by the editors, the 12 essays are as follows: "Reconnecting Foundations to the Substance of Teacher Education" (Lee S. Shulman); "A Reconceptualization of Educational Foundations" (Jonas F.…

  16. Foundational Studies in Teacher Education: A Reexamination. Special Issues from the Teachers College Record.

    ERIC Educational Resources Information Center

    Tozer, Steven, Ed.; Anderson, Thomas H., Ed.; Armbruster, Bonnie B., Ed.

    This collection of essays focuses on the role of psychological and cultural foundations in teacher education. Following an introduction by the editors, the 12 essays are as follows: "Reconnecting Foundations to the Substance of Teacher Education" (Lee S. Shulman); "A Reconceptualization of Educational Foundations" (Jonas F.…

  17. Gluon condensate in a pion superfluid beyond the mean-field approximation

    SciTech Connect

    Jiang Yin; Zhuang Pengfei

    2011-03-15

    We study gluon condensate in a pion superfluid by calculating the equation of state of the system in the Nambu-Jona-Lasinio model. While in mean-field approximation the growing pion condensate leads to an increasing gluon condensate, meson fluctuations reduce the gluon condensate, and the broken scalar symmetry can be smoothly restored at finite isospin density.

  18. A User-Centered Approach to the Design of an Expert System for Training.

    ERIC Educational Resources Information Center

    Borges, Marcos Augusto Francisco; Baranauskas, M. Cecilia C.

    1998-01-01

    Reports on a research project designed to develop an intelligent computer-based learning environment of industrial applications. "Jonas," an expert system, is part of a modeling/simulation environment which enables shop-floor workers to test and put new philosophies of work into practice in the context of manufacture. The approach focuses on the…

  19. Three Misunderstandings of Plato's Theory of Moral Education

    ERIC Educational Resources Information Center

    Jonas, Mark E.

    2016-01-01

    In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative…

  20. [Renowned scientist, pedagogue, and physician dedicated to the memory of the 110th anniversary of Bronius Sidaravicius's birth].

    PubMed

    Laurynaityte, Gryta; Lignugariene, Asta; Valiukeviciene, Skaidra

    2007-01-01

    This year we celebrate the 110th anniversary of Bronius Sidaravicius's (1897-1969) birth. He was a renowned Lithuanian dermato-venereologist, professor, head of the Department of Skin and Venereal Diseases at Vytautas Magnus University (1935-1946, 1956-1969), the founder and the chair of the Lithuanian Society of Dermato-venereologists, coeditor of the prewar journal "Medicina." He is an author of more than 100 articles and the very first course book on dermato-venereology in Lithuanian. He completed a part of his medical studies at universities in Germany. In Vienna University (1930), B. Sidaravicius performed clinical and experimental studies on the passive transmission of skin allergy, which had a major impact on the diagnostics of allergic skin diseases and specific desensibilization. He published the results of his study in the foreign literature and in the doctoral dissertation "Skin allergy and its treatment" in 1931. Thanks to the efforts of B. Sidaravicius and his colleagues, a progressive Law on Control and Prevention of Venereal Diseases was enacted in Lithuania. According to this Law, examinations and treatment of venereal diseases became compulsory and free of charge at state- or municipality-financed venereal outpatient units. This article was prepared on the basis of primary sources: protocols of the Council (the Faculty of Medicine, the University of Lithuania; since 1930 - Vytautas Magnus University) kept at the Museum of the History of Lithuania Medicine and Pharmacy as well as documents preserved at the Lithuanian State Archives and also scientific journals and periodicals both in Lithuanian and foreign languages.

  1. Pre-treatment with dexamethasone attenuates experimental ventilator-induced lung injury.

    PubMed

    Reis, Fernando Fonseca Dos; Reboredo, Maycon de Moura; Lucinda, Leda Marília Fonseca; Bianchi, Aydra Mendes Almeida; Rabelo, Maria Aparecida Esteves; Fonseca, Lídia Maria Carneiro da; Oliveira, Júlio César Abreu de; Pinheiro, Bruno Valle

    2016-01-01

    To evaluate the effects that administering dexamethasone before the induction of ventilator-induced lung injury (VILI) has on the temporal evolution of that injury. Wistar rats were allocated to one of three groups: pre-VILI administration of dexamethasone (dexamethasone group); pre-VILI administration of saline (control group); or ventilation only (sham group). The VILI was induced by ventilation at a high tidal volume. Animals in the dexamethasone and control groups were euthanized at 0, 4, 24, and 168 h after VILI induction. We analyzed arterial blood gases, lung edema, cell counts (total and differential) in the BAL fluid, and lung histology. At 0, 4, and 24 h after VILI induction, acute lung injury (ALI) scores were higher in the control group than in the sham group (p < 0.05). Administration of dexamethasone prior to VILI induction decreased the severity of the lung injury. At 4 h and 24 h after induction, the ALI score in the dexamethasone group was not significantly different from that observed for the sham group and was lower than that observed for the control group (p < 0.05). Neutrophil counts in BAL fluid were increased in the control and dexamethasone groups, peaking at 4 h after VILI induction (p < 0.05). However, the neutrophil counts were lower in the dexamethasone group than in the control group at 4 h and 24 h after induction (p < 0.05). Pre-treatment with dexamethasone also prevented the post-induction oxygenation impairment seen in the control group. Administration of dexamethasone prior to VILI induction attenuates the effects of the injury in Wistar rats. The molecular mechanisms of such injury and the possible clinical role of corticosteroids in VILI have yet to be elucidated. Avaliar os efeitos da administração de dexametasona antes da indução de lesão pulmonar induzida por ventilação mecânica (LPIVM) na evolução temporal dessa lesão. Ratos Wistar foram alocados em um dos três grupos: administração de dexametasona pr

  2. Tidal volume in acute respiratory distress syndrome: how best to select it.

    PubMed

    Umbrello, Michele; Marino, Antonella; Chiumello, Davide

    2017-07-01

    Mechanical ventilation is the type of organ support most widely provided in the intensive care unit. However, this form of support does not constitute a cure for acute respiratory distress syndrome (ARDS), as it mainly works by buying time for the lungs to heal while contributing to the maintenance of vital gas exchange. Moreover, it can further damage the lung, leading to the development of a particular form of lung injury named ventilator-induced lung injury (VILI). Experimental evidence accumulated over the last 30 years highlighted the factors associated with an injurious form of mechanical ventilation. The present paper illustrates the physiological effects of delivering a tidal volume to the lungs of patients with ARDS, and suggests an approach to tidal volume selection. The relationship between tidal volume and the development of VILI, the so called volotrauma, will be reviewed. The still actual suggestion of a lung-protective ventilatory strategy based on the use of low tidal volumes scaled to the predicted body weight (PBW) will be presented, together with newer strategies such as the use of airway driving pressure as a surrogate for the amount of ventilatable lung tissue or the concept of strain, i.e., the ratio between the tidal volume delivered relative to the resting condition, that is the functional residual capacity (FRC). An ultra-low tidal volume strategy with the use of extracorporeal carbon dioxide removal (ECCO2R) will be presented and discussed. Eventually, the role of other ventilator-related parameters in the generation of VILI will be considered (namely, plateau pressure, airway driving pressure, respiratory rate (RR), inspiratory flow), and the promising unifying framework of mechanical power will be presented.

  3. Ibuprofen Protects Ventilator-Induced Lung Injury by Downregulating Rho-Kinase Activity in Rats

    PubMed Central

    Lin, Chien-Huang; Chou, Hsiu-Chu

    2014-01-01

    Background. Ventilator-induced lung injury-(VILI-) induced endothelial permeability is regulated through the Rho-dependent signaling pathway. Ibuprofen inhibits Rho activation in animal models of spinal-cord injury and Alzheimer's disease. The study aims to investigate ibuprofen effects on high tidal volume associated VILI. Methods. Twenty-eight adult male Sprague-Dawley rats were randomized to receive a ventilation strategy with three different interventions for 2 h: (1) a high-volume zero-positive end-expiratory pressure (PEEP) (HVZP) group; (2) an HVZP + ibuprofen 15 mg/kg group; and (3) an HVZP + ibuprofen 30 mg/kg group. A fourth group without ventilation served as the control group. Rho-kinase activity was determined by ratio of phosphorylated ezrin, radixin, and moesin (p-ERM), substrates of Rho-kinase, to total ERM. VILI was characterized by increased pulmonary protein leak, wet-to-dry weight ratio, cytokines level, and Rho guanine nucleotide exchange factor (GEF-H1), RhoA activity, p-ERM/total ERM, and p-myosin light chain (MLC) protein expression. Results. Ibuprofen pretreatment significantly reduced the HVZP ventilation-induced increase in pulmonary protein leak, wet-to-dry weight ratio, bronchoalveolar lavage fluid interleukin-6 and RANTES levels, and lung GEF-H1, RhoA activity, p-ERM/total ERM, and p-MLC protein expression. Conclusion. Ibuprofen attenuated high tidal volume induced pulmonary endothelial hyperpermeability. This protective effect was associated with a reduced Rho-kinase activity. PMID:25019086

  4. Reflection makes sense of rotation of the eyes.

    PubMed

    Judge, S J

    2006-10-01

    Our 3-D percept of the world is constructed from the two-dimensional visual images on the retina of each eye, but these images and the relationships between them are affected by the 3-D rotations of each eye. These 3-D eye rotations are constrained to patterns such as Listing's law, or its generalisation 'L2', according to the context. Our understanding of the patterns of such three-dimensional eye rotations, and their effect on the retinal images, has been greatly advanced by the development of algebraic methods (Haustein, 1989; Tweed & Vilis, 1987; Westheimer, 1957) for calculating the effect of eye rotations. But not many would say, with Dirac, that they understand the equations describing the 3-D geometry in the sense that they have "a way of figuring out the characteristic of its solution without actually solving it" (Dirac, according to Feynman, Leighton, & Sands, 1964). I show here how the geometry of 3-D rotations of the eye and their visual effects can be made easier to understand by use of the principle that a rotation through angle alpha can be achieved by a pair of reflections in planes with an angular separation alpha/2, and a common line that is the rotation axis (Tweed, 1997b; Tweed, Cadera, & Vilis, 1990). Mathematically (see Appendix A), the method is equivalent to decomposing the unit quaternions so successfully used to study three-dimensional eye rotations (Tweed & Vilis, 1987; Westheimer, 1957) into pairs of pure quaternions (ones whose scalar part is zero) which represent the reflections (Coxeter, 1946).

  5. The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

    PubMed Central

    Sun, Xiaoguang; Elangovan, Venkateswaran Ramamoorthi; Mapes, Brandon; Camp, Sara M.; Sammani, Saad; Saadat, Laleh; Ceco, Ermelinda; Ma, Shwu-Fan; Flores, Carlos; MacDougall, Matthew S.; Quijada, Hector; Liu, Bin; Kempf, Carrie L.; Wang, Ting; Chiang, Eddie T.

    2014-01-01

    Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mechanical stress remain poorly understood. The objective of this study was to define the contribution of specific transcription factors, acute respiratory distress syndrome (ARDS)-associated single nucleotide polymorphisms (SNPs), and promoter demethylation to NAMPT transcriptional regulation in response to mechanical stress. In vivo NAMPT protein expression levels were examined in mice exposed to high tidal volume mechanical ventilation. In vitro NAMPT expression levels were examined in human pulmonary artery endothelial cells exposed to 5 or 18% cyclic stretch (CS), with NAMPT promoter activity assessed using NAMPT promoter luciferase reporter constructs with a series of nested deletions. In vitro NAMPT transcriptional regulation was further characterized by measuring luciferase activity, DNA demethylation, and chromatin immunoprecipitation. VILI-challenged mice exhibited significantly increased NAMPT expression in bronchoalveolar lavage leukocytes and in lung endothelium. A mechanical stress–inducible region (MSIR) was identified in the NAMPT promoter from −2,428 to −2,128 bp. This MSIR regulates NAMPT promoter activity, mRNA expression, and signal transducer and activator of transcription 5 (STAT5) binding, which is significantly increased by 18% CS. In addition, NAMPT promoter activity was increased by pharmacologic promoter demethylation and inhibited by STAT5 silencing. ARDS-associated NAMPT promoter SNPs rs59744560 (−948G/T) and rs7789066 (−2,422A/G) each significantly elevated NAMPT promoter activity in response to 18% CS in a STAT5-dependent manner. Our results show that NAMPT is a key novel ARDS therapeutic target and candidate gene with genetic

  6. Integrating microRNAs into a system biology approach to acute lung injury.

    PubMed

    Zhou, Tong; Garcia, Joe G N; Zhang, Wei

    2011-04-01

    Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various genetic and nongenetic factors. Using the candidate gene approach, genetic variants associated with immune response and inflammatory pathways have been identified and implicated in ALI. Because gene expression is an intermediate phenotype that resides between the DNA sequence variation and the higher level cellular or whole-body phenotypes, the illustration of gene expression regulatory networks potentially could enhance understanding of disease susceptibility and the development of inflammatory lung syndromes. MicroRNAs (miRNAs) have emerged as a novel class of gene regulators that play critical roles in complex diseases including ALI. Comparisons of global miRNA profiles in animal models of ALI and VILI identified several miRNAs (eg, miR-146a and miR-155) previously implicated in immune response and inflammatory pathways. Therefore, via regulation of target genes in these biological processes and pathways, miRNAs potentially contribute to the development of ALI. Although this line of inquiry exists at a nascent stage, miRNAs have the potential to be critical components of a comprehensive model for inflammatory lung disease built by a systems biology approach that integrates genetic, genomic, proteomic, epigenetic as well as environmental stimuli information. Given their particularly recognized role in regulation of immune and inflammatory responses, miRNAs also serve as novel therapeutic targets and biomarkers for ALI/ARDS or VILI, thus facilitating the realization of personalized medicine for individuals with acute inflammatory lung disease.

  7. Prophylactic erythropoietin exacerbates ventilation-induced lung inflammation and injury in preterm lambs.

    PubMed

    Polglase, Graeme R; Barton, Samantha K; Melville, Jacqueline M; Zahra, Valerie; Wallace, Megan J; Siew, Melissa L; Tolcos, Mary; Moss, Timothy J M

    2014-05-01

    Ventilation-induced lung injury (VILI) of preterm neonates probably contributes to the pathogenesis of bronchopulmonary dysplasia (BPD). Erythropoietin (EPO) has been suggested as a therapy for BPD. The aim of this study was to determine whether prophylactic administration of EPO reduces VILI in preterm newborn lambs. Lambs at 126 days of gestation (term is 147 days) were delivered and ventilated with a high tidal volume strategy for 15 min to cause lung injury, then received gentle ventilation until 2 h of age. Lambs were randomized to receive intravenous EPO (5000 IU kg(-1): Vent+EPO; n = 6) or phosphate-buffered saline (Vent; n = 7) soon after birth: unventilated controls (UVC; n = 8) did not receive ventilation or any treatment. Physiological parameters were recorded throughout the experimental procedure. Samples of lung were collected for histological and molecular assessment of inflammation and injury. Samples of liver were collected to assess the systemic acute phase response. Vent+EPO lambs received higher F IO 2, P aO 2 and oxygenation during the first 10 min than Vent lambs. There were no differences in physiological indices beyond this time. Total lung injury score, airway wall thickness, inflammation and haemorrhage were higher in Vent+EPO lambs than in Vent lambs. Lung inflammation and early markers of lung and systemic injury were elevated in ventilated lambs relative to unventilated lambs; EPO administration further increased lung inflammation and markers of lung and systemic injury. Prophylactic EPO exacerbates VILI, which may increase the incidence and severity of long-term respiratory disease. More studies are required before EPO can be used for lung protection in preterm infants.

  8. [Typus melancholicus and melancholia: Theoretical synthesis using a clinical case].

    PubMed

    Englebert, J; Stanghellini, G

    2016-02-01

    The aim of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to melancholia and typus melancholicus (TM), a clinical concept that describes the premorbid personality vulnerable to major depression ("melancholia" for the psychopathological tradition). This is a phenomenological analysis of a case study of melancholia, of its premorbid personality and pathogenic triggering situation. We adopt two main phenomenological keys to understand the development of melancholia: a role-identity theory and desynchronization theory. The former understands melancholia as a disorder of identity triggered by the loss of the social role with which one has previously over-identified. The latter sees melancholia as the effect of the desynchronization from the social environment that further develops into an inhibition of the cognative-affective dynamics of life. We present the case of Jonas (64 years old), whose mother (94 years old) recently died. Before his mother's death, Jonas' life was entirely orchestrated by the caring for his mother and synchronized in time with this (e.g., he used to go to her house every 4 hours, had all his meals with her, etc.). Jonas, in addition to being hyper-synchronized and hyper-syntonic, fulfills all diagnostic criteria for TM, including "orderliness", "conscientiousness", "hyper/heteronomia" and "intolerance of ambiguity". TMs attach a disproportioned importance to their social roles (or external representations of identity) at the expense of their own ego-identity. The passage from premorbid personality to melancholia is triggered by the death of Jonas' mother that entails a profound depersonalization. Desynchronization and role loss cause Jonas' fall into this severe depersonalization, the core feature of which is the feeling of the loss of feeling. This original contribution demonstrates that a clinical case can contribute to the

  9. Paediatric lung recruitment: a review of the clinical evidence.

    PubMed

    Jauncey-Cooke, Jacqui; East, Chris E; Bogossian, Fiona

    2015-03-01

    Lung recruitment is used as an adjunct to lung protective ventilation strategies. Lung recruitment is a brief, deliberate elevation of transpulmonary pressures beyond what is achieved during tidal ventilation levels. The aim of lung recruitment is to maximise the number of alveoli participating in gas exchange particularly in distal and dependant regions of the lung. This may improve oxygenation and end expiratory levels. Restoration of end expiratory levels and stabilisation of the alveoli may reduce the incidence of ventilator induced lung injury (VILI). Various methods of lung recruitment have been studied in adult and experimental populations. This review aims to establish the evidence for lung recruitment in the pediatric population.

  10. [Health economic evaluation of bivalent human papilloma virus vaccine in China: based on the dynamic model].

    PubMed

    Song, X B; Zhao, Q J; Zhou, Z; Fang, Y

    2017-09-06

    Objective: This study aims to evaluate the prevention effect and cost-effectiveness of a prophylactic bivalent human papilloma virus (HPV) vaccine. Methods: A multiple health status dynamic model was developed, including natural history of diseases and prevention strategies. We built 19 prevention strategies including visual inspection with acetic acid/lugol's iodine (VIA/VILI) and/or 3 does prophylactic bivalent HPV vaccine administered to adolescent girls at the age of 15 years old every year under the assumption that vaccine coverage and screening coverage were 70%. The incremental cost-effectiveness ratio (ICER), optimal price of 3 does vaccine and cost-effectiveness frontier of these strategies were analyzed compared with no-intervention. The ICER threshold is 152 087 CNY. Results: Compared with no-intervention, Routine vaccination reduced the incidence of cervical cancer by 69.5%, superior to 5 strategies including VIA/VILI screening only. The range of effect was between 9.0% and 69.2%, and the effect of strategy increased significantly with the increase of screening frequency. Combination vaccination with screening at ages of 35 reduced the incidence of cervical cancer by 72.0%, and the effect increased with the increase of screening frequency. Combination vaccination with screening every 3 years between (35-64) years old reduced the incidence by 89.4%. Compared with no-intervention, the ICER of combination vaccination with screening twice between 35 years and 64 years was 121 292 CNY/life-year, which was cost-effective. The price of vaccine had a significant impact on the ICER of the strategy; when the vaccine price was less than 600 CNY, only routine vaccination or supplementary vaccination between 16-39 years old after routine vaccination was cost-effective; when the vaccine price was less than 1 200 CNY, supplementary vaccination between 16-19 years old plus VIA/VILI was cost-effective. Conclusion: Ther prevention strategy was cost-effective, which could

  11. Image Analysis Program for Measuring Particles with the Zeiss CSM 950 Scanning Electron Microscope (SEM)

    DTIC Science & Technology

    1990-01-01

    7 𔄁 . ,: 1& *U _’ ś TECHNICAL REPORT AD NATICK/TR-90/014 (V) N* IMAGE ANALYSIS PROGRAM FOR MEASURING PARTICLES < WITH THE ZEISS CSM 950 SCANNING... image analysis program for measuring particles using the Zeiss CSM 950/Kontron system is as follows: A>CSM calls the image analysis program. Press D to...27 vili LIST OF TABLES TABLE PAGE 1. Image Analysis Program for Measuring 29 Spherical Particles 14 2. Printout of Statistical Data Frcm Table 1 16 3

  12. Portrait

    PubMed Central

    Granoff, Dan M.

    2013-01-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years—polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk’s efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. Later, Salk, Robbins and I shared a platform at an infectious diseases symposium, and I was privileged to speak at Robbins’ retirement. But that gets ahead of my story. In January 1956, at age 12 y, I received my first of dose of the “Salk” vaccine. Other kids had pictures of athletes in their rooms; I had a picture of Jonas Salk. PMID:23807081

  13. Phase diagram of quark-antiquark and diquark condensates in the 3-dimensional Gross-Neveu model with the 4-component spinor representation

    SciTech Connect

    Kohyama, Hiroaki

    2008-07-01

    We construct the phase diagram of the quark-antiquark and diquark condensates at finite temperature and density in the 2+1 dimensional (3D) two flavor massless Gross-Neveu (GN) model with the 4-component quarks. In contrast to the case of the 2-component quarks, there appears the coexisting phase of the quark-antiquark and diquark condensates. This is the crucial difference between the 2-component and 4-component quark cases in the 3D GN model. The coexisting phase is also seen in the 4D Nambu Jona-Lasinio model. Then we see that the 3D GN model with the 4-component quarks bears closer resemblance to the 4D Nambu Jona-Lasinio model.

  14. Precautionary discourse. Thinking through the distinction between the precautionary principle and the precautionary approach in theory and practice.

    PubMed

    Dinneen, Nathan

    2013-01-01

    This paper addresses the distinction, arising from the different ways the European Union and United States have come to adopt precaution regarding various environmental and health-related risks, between the precautionary principle and the precautionary approach in both theory and practice. First, this paper addresses how the precautionary principle has been variously defined, along with an exploration of some of the concepts with which it has been associated. Next, it addresses how the distinction between the precautionary principle and precautionary approach manifested itself within the political realm. Last, it considers the theoretical foundation of the precautionary principle in the philosophy of Hans Jonas, considering whether the principled-pragmatic distinction regarding precaution does or doesn't hold up in Jonas' thought.

  15. Portrait: coincidences, convergences and opportunities.

    PubMed

    Granoff, Dan M

    2013-05-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years-polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk's efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. Later, Salk, Robbins and I shared a platform at an infectious diseases symposium, and I was privileged to speak at Robbins' retirement. But that gets ahead of my story. In January 1956, at age 12 y, I received my first of dose of the "Salk" vaccine. Other kids had pictures of athletes in their rooms; I had a picture of Jonas Salk.

  16. Auricular Therapy for Treatment of Musculoskeletal Pain in the Setting of Military Personnel: A Randomized Trial

    DTIC Science & Technology

    2012-10-01

    addition of a specific auricular therapy protocol to standard care will have a beneficial impact on the pain and functionality of subjects who sustain...changes, etc) than usual care; c) more rapid and significant return of functional ability than usual care; and d) more rapid and significant reduction...Goertz CM, Niemtzow R, Burns SM, Fritts MJ, Crawford CC, Jonas WB. Auricular acupuncture in the treatment of acute pain syndromes: A pilot study. Mil Med

  17. Spin polarization versus color-flavor locking in high-density quark matter

    NASA Astrophysics Data System (ADS)

    Tsue, Yasuhiko; da Providência, João; Providência, Constança; Yamamura, Masatoshi; Bohr, Henrik

    2015-01-01

    It is shown that spin polarization with respect to each flavor in three-flavor quark matter occurs instead of color-flavor locking at high baryon density by using the Nambu-Jona-Lasinio model with four-point tensor-type interaction. Also, it is indicated that the order of phase transition between the color-flavor-locked phase and the spin-polarized phase is the first order by means of second-order perturbation theory.

  18. BEC-BCS crossover driven by the axial anomaly in the NJL model

    NASA Astrophysics Data System (ADS)

    Abuki, Hiroaki; Baym, Gordon; Hatsuda, Tetsuo; Yamamoto, Naoki

    2010-12-01

    We study the QCD phase structure in the three-flavor Nambu-Jona-Lasinio model, incorporating the chiral-diquark interplay due to the axial anomaly. We demonstrate that for a certain range of model parameters, the low temperature critical point predicted by a Ginzburg-Landau analysis appears in the phase diagram. In addition, we show that the axial anomaly presents a new scenario for a possible BEC-BCS crossover in the color-flavor locked phase of QCD.

  19. The Effect of Humidity on the Collection Efficiency for Oxygenated Compounds Absorbed on Activated Charcoal

    DTIC Science & Technology

    1990-08-01

    Adsorption Equilibria Using Ideal Adsorbed Solution Theory. Environmental Science Technology 19(11) 1037-43 (1985). 22. Crittenden, J. C,, R. D...of OrganiQ Vapors. Environmental Science Technology . 16: 10-14, (1981). 25. Jonas, L. A., R. B. Sansone, T. S. Farris: Prediction of Activated Carbon...char. In 1822, Bussy increased the adsorptive power of blood char twenty to fifty times through a heating process which altumately led to the

  20. Achieving Adaptability through Inquiry Based Learning

    DTIC Science & Technology

    2010-06-01

    knowledge. IBL is based on a different conception of learning, one traceable back to John Dewey (1910) and Jean Piaget (1972; von Glasersfeld, 1995) and...Dewey, 1910; Duffy 2009; Piaget , 1972; Schank, Fano, Bell, and Jona, 1993). If the learners are focused on figuring out what the instructor wants...errors or the inability to fully make sense of a situation provides the basis for learning ( Piaget , 1973; Schank, et al, 1993). Thus the errors

  1. Quark matter under strong magnetic fields in chiral models

    SciTech Connect

    Rabhi, Aziz; Providencia, Constanca

    2011-05-15

    The chiral model is used to describe quark matter under strong magnetic fields and is compared to other models, the MIT bag model and the two-flavor Nambu-Jona-Lasinio model. The effect of vacuum corrections due to the magnetic field is discussed. It is shown that if the magnetic-field vacuum corrections are not taken into account explicitly, the parameters of the models should be fitted to low-density meson properties in the presence of the magnetic field.

  2. Comprehensive Review of the Future Role of the Reserve Component. Volume 1. Executive Summary and Main Report

    DTIC Science & Technology

    2011-04-05

    Mr. Richard McCalla Mr. Julien Saramago USCENTCOM CDR Shaun Murphy USEUCOM COL Michael Godfrey COL James Minta CDR Jonas Jones... Josee Robidoux 119 Table B-2. Study Working Group Participants (Cont.) Johns Hopkins University Applied Physics Laboratory Mr. John...for Organizational Health. U.S. Army War College, Carlisle Barracks, PA: 23 March 2007. 128 Davis, Lieutenant Colonel Jose R. Army National

  3. Evaluation of Chemical and Atmospheric Sciences Research

    DTIC Science & Technology

    1984-09-09

    I Geil 48 Benesch 49 Niedenzu B/B+ 1 Marchand 26 El Batouay 9 Tuazon B 24 Maddou 33 Thompson23 Winefordner 21) Lauer 30) Me-’nzer 0’ SalK 7 Lin C 28...APOSR CHEMISTRY RESEARCH- EVALUATION CATE3GORY I CATEGORY TI A+36 Jonas 43 Field A 06 Hubbard 25 Williams 29 Bernstein 24 Smalley 19 Winograd * 14 Rice

  4. From inverse to delayed magnetic catalysis in a strong magnetic field

    NASA Astrophysics Data System (ADS)

    Mao, Shijun

    2016-08-01

    We study the magnetic field effect on chiral phase transition in a Nambu-Jona-Lasinio model. In comparison with a mean-field approximation containing only quarks, including mesons as quantum fluctuations in the model leads to a transition from inverse to delayed magnetic catalysis at finite temperature and delays the transition at finite baryon chemical potential. The location of the critical end point depends nonmonotonically on the magnetic field.

  5. Combat Analysis of Advanced Technology Weapons Concepts

    DTIC Science & Technology

    2007-11-02

    determined from equations summarized in "High Velocity Impact Dynamics" by Dr. Jonas Zukas These equations are derived by assuming that non-deforming...damage rating, whether or not the impact creates spall, and the projectile’s damage properties. Additional calculations are performed to determine special... impact of a projectile (or sub projectile) or blast wave on the target. Instead, these weapons cause destruction by overloading specific components of

  6. Cognitive and Motivational Consequences of Tutoring and Discovery Learning

    DTIC Science & Technology

    1998-06-01

    Proponents of Discovery Learning A leading advocate of early interest in discovery learning was Jerome Bruner (1961, 1966). Bruner argued that learning...them, and should be free to make errors and learn by recovering from them ( Bruner , 1961; Papert, 1980; Schänk & Jona, 1991). In con- trast...and sponta- neously form new hypotheses about the topic of the learning. Bruner argued that the instruction process is more meaningful to learners

  7. Private Military Companies: Analyzing the Use of Armed Contractors

    DTIC Science & Technology

    2007-12-01

    These intellectual arguments were reinforced by the economic arguments of Milton Friedman, who expounded on the virtues of free markets and limited...1999), 361-67. 27 Ibid., 336-414. 28 Ibid., 368-70. 29 Milton Friedman, Capitalism and Freedom (Chicago: The University of Chicago Press, 1962), 2...government, led by MPLA president, Jose Eduardo dos Santos , was on the verge of defeat at the hands of UNITA rebels led by Jonas Savimbi.45 It hired

  8. QCD phase structure at finite temperature in three-flavor random matrix theory

    SciTech Connect

    Arai, Ryoichi; Yoshinaga, Naotaka

    2009-07-01

    The QCD phase structure is studied at finite temperature in a three-flavor random matrix model formulated with nonzero quark chemical potentials. In the case of no flavor mixing, we analytically obtain temperature dependent critical chemical potentials for finite quark masses. Numerical results show that the QCD phase diagram as a function of temperature is qualitatively in agreement with the prediction of the Nambu-Jona-Lasinio model.

  9. Anomalous diffraction approximation limits

    NASA Astrophysics Data System (ADS)

    Videen, Gorden; Chýlek, Petr

    It has been reported in a recent article [Liu, C., Jonas, P.R., Saunders, C.P.R., 1996. Accuracy of the anomalous diffraction approximation to light scattering by column-like ice crystals. Atmos. Res., 41, pp. 63-69] that the anomalous diffraction approximation (ADA) accuracy does not depend on particle refractive index, but instead is dependent on the particle size parameter. Since this is at odds with previous research, we thought these results warranted further discussion.

  10. Fluids, Gels and Glasses Under Extreme Conditions of Pressure and Temperature

    DTIC Science & Technology

    1989-02-17

    some borosiloxane (=B-O-Si ) linkages are formed in solution, their concentration dimin- ishes toward gelation due to re-hydrolysis to form boric acid ...Borosilo- xane units are not stable in these solutions containing excess water and alcohol. The boric acid does, however, condense to form...Polymerization Processes in Acid and Base Catalyzed Silica Sol-Gels," T. W. Zerda, I. Artaki and J. Jonas, J. Non-Crystalline Sol- ids, 81, 365 (1986

  11. Two-Loop Effective Action for Theories with Fermions

    NASA Astrophysics Data System (ADS)

    Faizullaev, B. A.; Musakhanov, M. M.

    1995-08-01

    On the basis of a new approach for the calculation of the effective action developed in our previous works we calculate the effective action (up to two-loop level) for some models containing fermion fields. This method allows us to calculate the fermionic part of the effective action properly. The two-loop contribution to the effective potential for the Nambu-Jona-Lasinio model is calculated and is shown to vanish.

  12. Physiologic Aspects of Porcine Hemorrhage. IV. Blood Gas and Acid-Base Status of the Conscious Animal Following 30 and 50 Percent Blood Loss.

    DTIC Science & Technology

    1981-12-01

    we have reported details of the procurement, housing, surgical implantation of chronic catheters, postsurgical treatment, hemorrhage procedure, and...JONA. Recherches experimentales sur quelques alterations du sang apres la saign~e. Arch Anat Physiol 27:37-44, 1895 4. SPIRO, as cited by RAYMOND, B...Superintendent Commander Academy of Health Sciences US Army Institute of Dental Research ATTN: AHS-COM Washington DC 20012 Fort Sam Houston TX 78234

  13. Quark confinement in a constituent quark model

    SciTech Connect

    Langfeld, K.; Rho, M.

    1995-07-01

    On the level of an effective quark theory, we define confinement by the absence of quark anti-quark thresholds in correlation function. We then propose a confining Nambu-Jona-Lasinio-type model. The confinement is implemented in analogy to Anderson localization in condensed matter systems. We study the model`s phase structure as well as its behavior under extreme conditions, i.e. high temperature and/or high density.

  14. Nucleon quark distributions in a covariant quark-diquark model

    SciTech Connect

    Ian Cloet; W. Bentz; Anthony Thomas

    2005-04-01

    Spin-dependent and spin-independent quark light-cone momentum distributions and structure functions are calculated for the nucleon. We utilize a modified Nambu-Jona-Lasinio model in which confinement is simulated by eliminating unphysical thresholds for nucleon decay into quarks. The nucleon bound state is obtained by solving the Faddeev equation in the quark-diquark approximation, where both scalar and axial-vector diquarks channels are included. We find excellent agreement between our model results and empirical data.

  15. Guanidino Groups Greatly Enhance the Action of Antimicrobial Peptidomimetics Against Bacterial Cytoplasmic Membranes

    DTIC Science & Technology

    2014-05-28

    ARO 8. PERFORMING ORGANIZATION REPORT NUMBER 19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER Jay Schieber Konstantin Andreev , Christopher...bacterial cytoplasmic membranes Konstantin Andreev a,b,1, Christopher Bianchi a,b,1, Jonas S. Laursen c, Linda Citterio d, Line Hein-Kristensen e, Lone Gram...protonated state together with efficient solvation in water, which makes them stronger bases and, thus, better suited for stable electrostatic

  16. Genetic Targets of Hydrogen Sulfide in Ventilator-Induced Lung Injury – A Microarray Study

    PubMed Central

    Spassov, Sashko; Pfeifer, Dietmar; Strosing, Karl; Ryter, Stefan; Hummel, Matthias; Faller, Simone; Hoetzel, Alexander

    2014-01-01

    Recently, we have shown that inhalation of hydrogen sulfide (H2S) protects against ventilator-induced lung injury (VILI). In the present study, we aimed to determine the underlying molecular mechanisms of H2S-dependent lung protection by analyzing gene expression profiles in mice. C57BL/6 mice were subjected to spontaneous breathing or mechanical ventilation in the absence or presence of H2S (80 parts per million). Gene expression profiles were determined by microarray, sqRT-PCR and Western Blot analyses. The association of Atf3 in protection against VILI was confirmed with a Vivo-Morpholino knockout model. Mechanical ventilation caused a significant lung inflammation and damage that was prevented in the presence of H2S. Mechanical ventilation favoured the expression of genes involved in inflammation, leukocyte activation and chemotaxis. In contrast, ventilation with H2S activated genes involved in extracellular matrix remodelling, angiogenesis, inhibition of apoptosis, and inflammation. Amongst others, H2S administration induced Atf3, an anti-inflammatory and anti-apoptotic regulator. Morpholino mediated reduction of Atf3 resulted in elevated lung injury despite the presence of H2S. In conclusion, lung protection by H2S during mechanical ventilation is associated with down-regulation of genes related to oxidative stress and inflammation and up-regulation of anti-apoptotic and anti-inflammatory genes. Here we show that Atf3 is clearly involved in H2S mediated protection. PMID:25025333

  17. Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies.

    PubMed

    Hopster, K; Jacobson, B; Hopster-Iversen, C; Rohn, K; Kästner, S B R

    2016-08-01

    Inappropriate mechanical ventilation can lead to ventilator-induced lung injury (VILI). Aim of this study was to evaluate the effects of inhalation anaesthesia and ventilation with and without recruitment (RM) and PEEP titration on alveolar integrity in horses. Twenty-three horses were divided into 4 groups (group OLC ventilated with OLC, group IPPV ventilated with intermittent positive pressure ventilation, group NV non-ventilated, and group C non-anaesthetized control group). After sedation with xylazine and induction with diazepam and ketamine anaesthetized horses were under isoflurane anaesthesia for 5.5h. The horses were euthanized and tissue samples of the dependent and non-dependent lung areas were collected. Histopathological examinations of the lung tissue as well as relative quantification of mRNA of IL-1β, IL-6, iNOS, MMP1 and MMP9 by PCR were performed. Horses of group OLC had significantly less alveolar congestion and atelectasis but greater alveolar overdistension compared to groups NV and IPPV. In groups OLC and group IPPV an increase in IL-1β/6 and MMP1/9 was detected compared to groups NV and C. In conclusion, in breathing spontaneously or IPPV-ventilated horses a higher degree of atelectasis was detected, whereas in OLC-ventilated horses a higher degree of overdistention was present. Elevated levels in IL and MMP might be early signs of VILI in ventilated horses.

  18. Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury

    PubMed Central

    2010-01-01

    Background Although mechanical ventilation (MV) is a major supportive therapy for patients with acute respiratory distress syndrome, it may result in side effects including lung injury. In this study we hypothesize that MMP-9 inhibition by doxycycline might reduce MV-related lung damage. Using a proteomic approach we identified the pulmonary proteins altered in high volume ventilation-induced lung injury (VILI). Forty Wistar rats were randomized to an orally pretreated with doxycycline group (n = 20) or to a placebo group (n = 20) each of which was followed by instrumentation prior to either low or high tidal volume mechanical ventilation. Afterwards, animals were euthanized and lungs were harvested for subsequent analyses. Results Mechanical function and gas exchange parameters improved following treatment with doxycycline in the high volume ventilated group as compared to the placebo group. Nine pulmonary proteins have shown significant changes between the two biochemically analysed (high volume ventilated) groups. Treatment with doxycycline resulted in a decrease of pulmonary MMP-9 activity as well as in an increase in the levels of soluble receptor for advanced glycation endproduct, apoliporotein A-I, peroxiredoxin II, four molecular forms of albumin and two unnamed proteins. Using the pharmacoproteomic approach we have shown that treatment with doxycycline leads to an increase in levels of several proteins, which could potentially be part of a defense mechanism. Conclusion Administration of doxycycline might be a significant supportive therapeutic strategy in prevention of VILI. PMID:20205825

  19. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

    PubMed Central

    Tao, Shasha; Rojo de la Vega, Montserrat; Quijada, Hector; Wondrak, Georg T.; Wang, Ting; Garcia, Joe G. N.; Zhang, Donna D.

    2016-01-01

    Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due to lung edema, trauma, or general anesthesia. However, MV causes ventilator-induced lung injury (VILI), a condition characterized by increased permeability of the alveolar-capillary barrier that results in edema, hemorrhage, and neutrophil infiltration, leading to exacerbated lung inflammation and oxidative stress. This study explored the feasibility of using bixin, a canonical NRF2 inducer identified during the current study, to ameliorate lung damage in a murine VILI model. In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo. Remarkably, IP administration of bixin restored normal lung morphology and attenuated inflammatory response and oxidative DNA damage following MV. This observed beneficial effect of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nrf2+/+ but not in Nrf2−/− mice. This is the first study providing proof-of-concept that NRF2 activators can be developed into pharmacological agents for clinical use to prevent patients from lung injury during MV treatment. PMID:26729554

  20. An approach to ventilation in acute respiratory distress syndrome

    PubMed Central

    Houston, Patricia

    2000-01-01

    Appropriate management of patients with acute respiratory distress syndrome (ARDS) represents a challenge for physicians working in the critical care environment. Significant advances have been made in understanding the pathophysiology of ARDS. There is also an increasing appreciation of the role of ventilator-induced lung injury (VILI). VILI is most likely related to several different aspects of ventilator management: barotrauma due to high peak airway pressures, lung overdistension or volutrauma due to high transpulmonary pressures, alveolar membrane damage due to insufficient positive end-expiratory pressure levels and oxygen-related cell toxicity. Various lung protective strategies have been suggested to minimize the damage caused by conventional modes of ventilation. These include the use of pressure- and volume-limited ventilation, the use of the prone position in the management of ARDS, and extracorporeal methods of oxygen delivery and carbon dioxide removal. Although the death rate resulting from ARDS has been declining over the past 10 years, there is no evidence that any specific treatment or change in approach to ventilation is the cause of this improved survival. PMID:10948686

  1. [The basics on mechanical ventilation support in acute respiratory distress syndrome].

    PubMed

    Tomicic, V; Fuentealba, A; Martínez, E; Graf, J; Batista Borges, J

    2010-01-01

    Acute Respiratory Distress Syndrome (ARDS) is understood as an inflammation-induced disruption of the alveolar endothelial-epithelial barrier that results in increased permeability and surfactant dysfunction followed by alveolar flooding and collapse. ARDS management relies on mechanical ventilation. The current challenge is to determine the optimal ventilatory strategies that minimize ventilator-induced lung injury (VILI) while providing a reasonable gas exchange. The data support that a tidal volume between 6-8 ml/kg of predicted body weight providing a plateau pressure < 30 cmH₂O should be used. High positive end expiratory pressure (PEEP) has not reduced mortality, nevertheless secondary endpoints are improved. The rationale used for high PEEP argues that it prevents cyclic opening and closing of airspaces, probably the major culprit of development of VILI. Chest computed tomography has contributed to our understanding of anatomic-functional distribution patterns in ARDS. Electric impedance tomography is a technique that is radiation-free, but still under development, that allows dynamic monitoring of ventilation distribution at bedside. Copyright © 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.

  2. Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

    PubMed Central

    Nelson, Kevin; Bobba, Christopher; Eren, Emre; Spata, Tyler; Tadres, Malak; Hayes,, Don; Black, Sylvester M.

    2015-01-01

    The number of acceptable donor lungs available for lung transplantation is severely limited due to poor quality. Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess organs and expand the donor pool. As this technology expands and improves, the ability to potentially evaluate and improve the quality of substandard lungs prior to transplant is a critical need. In order to more rigorously evaluate these approaches, a reproducible animal model needs to be established that would allow for testing of improved techniques and management of the donated lungs as well as to the lung-transplant recipient. In addition, an EVLP animal model of associated pathologies, e.g., ventilation induced lung injury (VILI), would provide a novel method to evaluate treatments for these pathologies. Here, we describe the development of a rat EVLP lung program and refinements to this method that allow for a reproducible model for future expansion. We also describe the application of this EVLP system to model VILI in rat lungs. The goal is to provide the research community with key information and “pearls of wisdom”/techniques that arose from trial and error and are critical to establishing an EVLP system that is robust and reproducible. PMID:25741794

  3. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell

    PubMed Central

    2014-01-01

    Introduction Ventilator-induced lung injury (VILI) impacts clinical outcomes in acute respiratory distress syndrome (ARDS), which is characterized by neutrophil-mediated inflammation and loss of alveolar barrier function. Recent epidemiological studies suggest that smoking may be a risk factor for the development of ARDS. Because alveolar type II cells are central to maintaining the alveolar epithelial barrier during oxidative stress, mediated in part by neutrophilic inflammation and mechanical ventilation, we hypothesized that exposure to cigarette smoke and mechanical strain have interactive effects leading to the activation of and damage to alveolar type II cells. Methods To determine if cigarette smoke increases susceptibility to VILI in vivo, a clinically relevant rat model was established. Rats were exposed to three research cigarettes per day for two weeks. After this period, some rats were mechanically ventilated for 4 hours. Bronchoalveolar lavage (BAL) and differential cell count was done and alveolar type II cells were isolated. Proteomic analysis was performed on the isolated alveolar type II cells to discover alterations in cellular pathways at the protein level that might contribute to injury. Effects on levels of proteins in pathways associated with innate immunity, oxidative stress and apoptosis were evaluated in alveolar type II cell lysates by enzyme-linked immunosorbent assay. Statistical comparisons were performed by t-tests, and the results were corrected for multiple comparisons using the false discovery rate. Results Tobacco smoke exposure increased airspace neutrophil influx in response to mechanical ventilation. The combined exposure to cigarette smoke and mechanical ventilation significantly increased BAL neutrophil count and protein content. Neutrophils were significantly higher after smoke exposure and ventilation than after ventilation alone. DNA fragments were significantly elevated in alveolar type II cells. Smoke exposure did not

  4. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

    NASA Astrophysics Data System (ADS)

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F.; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  5. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

    PubMed

    Henriques, Isabela; Padilha, Gisele A; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J B; Ramos, Isalira P; Rocha, Nazareth; Cruz, Fernanda F; Santos, Raquel S; de Oliveira, Milena V; Souza, Sergio A; Goldenberg, Regina C; Luiz, Ronir R; Pelosi, Paolo; de Abreu, Marcelo G; Silva, Pedro L; Rocco, Patricia R M

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  6. Using the one-lung method to link p38 to pro-inflammatory gene expression during overventilation in C57BL/6 and BALB/c mice.

    PubMed

    Siegl, Stephanie; Uhlig, Stefan

    2012-01-01

    The mechanisms of ventilator-induced lung injury (VILI), including the role of MAP kinases, are frequently studied in different mouse strains. A useful model for such studies is the isolated perfused mouse lung. As a further development we present the one-lung method that permits to continue perfusion and ventilation of the right lung after removal of the left lung. This method was used to compare the effect of high pressure ventilation (HPV) on pro-inflammatory signaling events in two widely used mouse strains (C57BL/6, BALB/c) and to further define the role of p38 in VILI. Lungs were perfused and ventilated for 30 min under control conditions before they were randomized to low (8 cm H(2)O) or high (25 cm H(2)O) pressure ventilation (HPV) for 210 min, with the left lung being removed after 180 min. In the left lung we measured the phosphorylation of p38, JNK, ERK and Akt kinase, and in the right lung gene expression and protein concentrations of Il1b, Il6, Tnf, Cxcl1, Cxcl2, and Areg. Lung mechanics and kinase activation were similar in both mouse strains. HPV increased all genes (except Tnf in BALB/c) and all mediators in both strains. The gene expression of mRNA for Il1b, Il6, Cxcl1 and Cxcl2 was higher in BALB/c mice. Backward regression of the kinase data at t = 180 min with the gene and protein expression data at t = 240 min suggested that p38 controls HPV-induced gene expression, but not protein production. This hypothesis was confirmed in experiments with the p38-kinase inhibitor SB203580. The one-lung method is useful for mechanistic studies in the lungs. While C57BL/6 show diminished pro-inflammatory responses during HPV, lung mechanics and mechanotransduction processes appear to be similar in both mouse strains. Finally, the one-lung method allowed us to link p38 to gene expression during VILI.

  7. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema

    PubMed Central

    Henriques, Isabela; Padilha, Gisele A.; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J. B.; Ramos, Isalira P.; Rocha, Nazareth; Cruz, Fernanda F.; Santos, Raquel S.; de Oliveira, Milena V.; Souza, Sergio A.; Goldenberg, Regina C.; Luiz, Ronir R.; Pelosi, Paolo; de Abreu, Marcelo G.; Silva, Pedro L.; Rocco, Patricia R. M.

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  8. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome.

    PubMed

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  9. The influence of meteorological factors on growth and vegetation process of Perilla frutescens (L.) Britton in Lithuania.

    PubMed

    Ragazinskiene, Ona; Seinauskiene, Erika; Janulis, Valdimaras; Jankauskaite, Lina; Milasius, Arvydas

    2006-01-01

    The results of a study on the dependence of growth and vegetation process of Perilla frutescens (L.) Britton upon meteorological factors are presented in the article. The investigations were conducted at Kaunas Botanical Garden of Vytautas Magnus University during vegetation periods in 2001-2005. The object of investigations was Perilla frutescens (L.) Britton, a medicinal annual herbaceous plant of Lamiaceae Lindl. family, native of Eastern Asia, which passes the whole development cycle under climatic conditions of Central Lithuania. The duration of vegetation period of Perilla frutescens on the average is 167 days. The earliest beginning of vegetation and optimal climatic conditions for growth are when hydrothermic coefficient reaches 1.60-1.80 (conditions of excessive humidity). Optimal climatic conditions for massive flowering and seed maturation are observed when hydrothermic coefficient decreases to 1.20 - then massive flowering starts 10 days earlier and lasts 25 days longer. A strong correlation was found between massive flowering and hydrothermic coefficient (r(2)=0.9408). Using mathematical-statistical methods, the consistent patterns of growth and vegetation process of Perilla frutescens (L.) Britton were determined, specifying the time for raw material preparation what determines its quality and quantity.

  10. [Diversity of phytophagous and pathogens and their damage to mints (Mentha)].

    PubMed

    Juronis, Vidmantas; Snieskiene, Vilija

    2004-01-01

    The aim of this work was to estimate the phytopathologic condition of mints grown and self-growing in Kaunas Botanical Garden of Vytautas Magnus University and elsewhere in Lithuania; and to identify the specific constitution, the spread and damage of the main pests and disease agents. Observations and examination were carried out with two local, four introduced mint species and with four hybrids in 1997-2003. We estimated the plant condition by identifying the intensity of the diseases and the abundance, spreading and damage of the pests. During the study we detected and identified the following pests--agents of diseases: Puccinia menthae, Erysiphe biocellata and Verticillium sp.; and phytophagous: Tetranychus urticae, Eupteryx atropunctata, Ovatus crataegarius, Polia persicariae, Agriotes lineatus, Chrysomela coerulans, Cassida viridis, Longitarsus lycopi. The most dangerous mint disease in Lithuania is rust; pests causing more harm are: Eupteryx atropunctata, Longitarsus lycopi. According to our data the least resistant species to most diseases and pests were Mentha arvensis and Mentha piperita, however separate samples of these species were exceptionally resistant. More resistant species was Mentha spicata and its hybrids.

  11. Word Frequency Analysis MOS: 17C. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    rVERLAPPING 5 OVERLAY 3 nVT’LAYS 7 nVERWATCH 6 OWN 23 P I Ph 7 P AC IN W- PACKAGES I PAr.KET I P vily 77 P AGE LQ PArFS 2 PAIN I PAI4T I PAIPNTED 1...rntJNII wnRp𔃻 COUNT? WORD2 CC ON T3 w~p n 3 rrIuNTA WCR04 2 OVERt APPINr. 2 nYPFRUATCH 2 PACING > P VErGEc-S - 2 PAIN 2 PAIR p AAPER I PITIL 2 P ARTI...CLOSING 13 GROI )ND 13 -SiRVT 13 S~TPS 13 SWITCH 12 nOIST ANCE 12 14VIGHT d 12 LOCATIOn4 12 NCTE 17 PFrIL It1 PrSTITI nN 11 AN it APPROPRIATE 11 AREA

  12. United States Army, Seventh Army Field Order No. 1 (ANVIL)

    DTIC Science & Technology

    1944-07-29

    BLOUNT 49 lAt,JRA KEENE 17 JOHN B. HOOD 13 GEORGE !ifiEADE Carries approx 6600 tons maintenance lV.tII’ only M/T only 3rd Division Ships. -\\25...Aiv1ES RUll’PEY I MIT onlyI 15 GEORGE LEONARD MIT only t I ! i ; __ H_._. i .i·’ 𔃻’I!𔄂F 𔄂!leMr Air Force Ships .. 1/2 of capac i ty reserved for Ar...iVILI:.I1111’I J.:\\.C.KSON 30 ETHAN ~T\\J 32 GEORGE McCRARY 39 !,L.RI ON BOV.:illD 27 ABEL STE..:J1Lŕ’S 31 FUmi’IFOLD SIJ.,JlVIONS - 34 HOWEll E. J

  13. Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India.

    PubMed

    Arbyn, Marc; Sankaranarayanan, Rengaswamy; Muwonge, Richard; Keita, Namory; Dolo, Amadou; Mbalawa, Charles Gombe; Nouhou, Hassan; Sakande, Boblewende; Wesley, Ramani; Somanathan, Thara; Sharma, Anjali; Shastri, Surendra; Basu, Parthasarathy

    2008-07-01

    Cervical cancer is the main cancer among women in sub-Saharan Africa, India and other parts of the developing world. Evaluation of screening performance of effective, feasible and affordable early detection and management methods is a public health priority. Five screening methods, naked eye visual inspection of the cervix uteri after application of diluted acetic acid (VIA), or Lugol's iodine (VILI) or with a magnifying device (VIAM), the Pap smear and human papillomavirus testing with the high-risk probe of the Hybrid Capture-2 assay (HC2), were evaluated in 11 studies in India and Africa. More than 58,000 women, aged 25-64 years, were tested with 2-5 screening tests and outcome verification was done on all women independent of the screen test results. The outcome was presence or absence of cervical intraepithelial neoplasia (CIN) of different degrees or invasive cervical cancer. Verification was based on colposcopy and histological interpretation of colposcopy-directed biopsies. Negative colposcopy was accepted as a truly negative outcome. VIA showed a sensitivity of 79% (95% CI 73-85%) and 83% (95% CI 77-89%), and a specificity of 85% (95% CI 81-89%) and 84% (95% CI 80-88%) for the outcomes CIN2+ or CIN3+, respectively. VILI was on average 10% more sensitive and equally specific. VIAM showed similar results as VIA. The Pap smear showed lowest sensitivity, even at the lowest cutoff of atypical squamous cells of undetermined significance (57%; 95% CI 38-76%) for CIN2+ but the specificity was rather high (93%; 95% CI 89-97%). The HC2-assay showed a sensitivity for CIN2+ of 62% (95% CI 56-68%) and a specificity of 94% (95% CI 92-95%). Substantial interstudy variation was observed in the accuracy of the visual screening methods. Accuracy of visual methods and cytology increased over time, whereas performance of HC2 was constant. Results of visual tests and colposcopy were highly correlated. This study was the largest ever done that evaluates the cross

  14. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung.

    PubMed

    Almendros, Isaac; Gutierrez, Patricia T; Closa, Daniel; Navajas, Daniel; Farre, Ramon

    2008-06-30

    The aim was to assess whether induction of ventilator-induced lung injury (VILI) in one lung triggers a concomitant inflammatory response in the normally ventilated contralateral lung. To this end, a differential ventilator was used in 6 rats. One lung was normally ventilated (3.5 ml/kg b.w.) and the contralateral lung was overstretched (15 ml/kg b.w.). Six control rats were normally ventilated (3.5 ml/kg b.w. each lung). After 3h, edema and gene expression of MIP-2 in the lung, and plasma and liver TNF-alpha were assessed. Overexpression of MIP-2 and edema were found in the overventilated lung but not in the normally ventilated contralateral lung. No detectable levels of circulating and liver TNF-alpha were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation.

  15. μ-PIV/Shadowgraphy measurements to elucidate dynamic physicochemical interactions in a multiphase model of pulmonary airway reopening

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Eiichiro

    2010-10-01

    We employ micro-particle image velocimetry (μ-PIV) and shadowgraphy to measure the ensemble-averaged fluid-phase velocity field and interfacial geometry during pulsatile bubble propagation that includes a reverse-flow phase under influence of exogenous lung surfactant (Infasurf). Disease states such as respiratory distress syndrome (RDS) are characterized by insufficient pulmonary surfactant concentrations that enhance airway occlusion and collapse. Subsequent airway reopening, driven by mechanical ventilation, may generate damaging stresses that cause ventilator-induced lung injury (VILI). It is hypothesized that reverse flow may enhance surfactant uptake and protect the lung from VILI. The microscale observations conducted in this study will provide us with a significant understanding of dynamic physicochemical interactions that can be manipulated to reduce the magnitude of this damaging mechanical stimulus during airway reopening. Bubble propagation through a liquid-occluded fused glass capillary tube is controlled by linear-motor-driven syringe pumps that provide mean and sinusoidal velocity components. A translating microscope stage mechanically subtracts the mean velocity of the bubble tip in order to hold the progressing bubble tip in the microscope field of view. To optimize the signal-to-noise ratio near the bubble tip, μ-PIV and shadow images are recorded in separate trials then combined during post-processing with help of a custom-designed micro scale marker. Non-specific binding of Infasurf proteins to the channel wall is controlled by oxidation and chemical treatment of the glass surface. The colloidal stability and dynamic/static surface properties of the Infasurf-PIV particle solution are carefully adjusted based on Langmuir trough measurements. The Finite Time Lyapunov Exponent (FTLE) is computed to provide a Lagrangian perspective for comparison with our boundary element predictions.

  16. Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation.

    PubMed

    Schranz, C; Becher, T; Schädler, D; Weiler, N; Möller, K

    2014-03-01

    Mechanical ventilation carries the risk of ventilator-induced-lung-injury (VILI). To minimize the risk of VILI, ventilator settings should be adapted to the individual patient properties. Mathematical models of respiratory mechanics are able to capture the individual physiological condition and can be used to derive personalized ventilator settings. This paper presents model-based calculations of inspiration pressure (pI), inspiration and expiration time (tI, tE) in pressure-controlled ventilation (PCV) and a retrospective evaluation of its results in a group of mechanically ventilated patients. Incorporating the identified first order model of respiratory mechanics in the basic equation of alveolar ventilation yielded a nonlinear relation between ventilation parameters during PCV. Given this patient-specific relation, optimized settings in terms of minimal pI and adequate tE can be obtained. We then retrospectively analyzed data from 16 ICU patients with mixed pathologies, whose ventilation had been previously optimized by ICU physicians with the goal of minimization of inspiration pressure, and compared the algorithm's 'optimized' settings to the settings that had been chosen by the physicians. The presented algorithm visualizes the patient-specific relations between inspiration pressure and inspiration time. The algorithm's calculated results highly correlate to the physician's ventilation settings with r = 0.975 for the inspiration pressure, and r = 0.902 for the inspiration time. The nonlinear patient-specific relations of ventilation parameters become transparent and support the determination of individualized ventilator settings according to therapeutic goals. Thus, the algorithm is feasible for a variety of ventilated ICU patients and has the potential of improving lung-protective ventilation by minimizing inspiratory pressures and by helping to avoid the build-up of clinically significant intrinsic positive end-expiratory pressure.

  17. Airway pressure release ventilation reduces conducting airway micro-strain in lung injury.

    PubMed

    Kollisch-Singule, Michaela; Emr, Bryanna; Smith, Bradford; Ruiz, Cynthia; Roy, Shreyas; Meng, Qinghe; Jain, Sumeet; Satalin, Joshua; Snyder, Kathy; Ghosh, Auyon; Marx, William H; Andrews, Penny; Habashi, Nader; Nieman, Gary F; Gatto, Louis A

    2014-11-01

    Improper mechanical ventilation can exacerbate acute lung damage, causing a secondary ventilator-induced lung injury (VILI). We hypothesized that VILI can be reduced by modifying specific components of the ventilation waveform (mechanical breath), and we studied the impact of airway pressure release ventilation (APRV) and controlled mandatory ventilation (CMV) on the lung micro-anatomy (alveoli and conducting airways). The distribution of gas during inspiration and expiration and the strain generated during mechanical ventilation in the micro-anatomy (micro-strain) were calculated. Rats were anesthetized, surgically prepared, and randomized into 1 uninjured control group (n = 2) and 4 groups with lung injury: APRV 75% (n = 2), time at expiration (TLow) set to terminate appropriately at 75% of peak expiratory flow rate (PEFR); APRV 10% (n = 2), TLow set to terminate inappropriately at 10% of PEFR; CMV with PEEP 5 cm H2O (PEEP 5; n = 2); or PEEP 16 cm H2O (PEEP 16; n = 2). Lung injury was induced in the experimental groups by Tween lavage and ventilated with their respective settings. Lungs were fixed at peak inspiration and end expiration for standard histology. Conducting airway and alveolar air space areas were quantified and conducting airway micro-strain was calculated. All lung injury groups redistributed inspired gas away from alveoli into the conducting airways. The APRV 75% minimized gas redistribution and micro-strain in the conducting airways and provided the alveolar air space occupancy most similar to control at both inspiration and expiration. In an injured lung, APRV 75% maintained micro-anatomic gas distribution similar to that of the normal lung. The lung protection demonstrated in previous studies using APRV 75% may be due to a more homogeneous distribution of gas at the micro-anatomic level as well as a reduction in conducting airway micro-strain. Copyright © 2014 American College of Surgeons. All rights reserved.

  18. Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study.

    PubMed

    Bein, Thomas; Weber-Carstens, Steffen; Goldmann, Anton; Müller, Thomas; Staudinger, Thomas; Brederlau, Jörg; Muellenbach, Ralf; Dembinski, Rolf; Graf, Bernhard M; Wewalka, Marlene; Philipp, Alois; Wernecke, Klaus-Dieter; Lubnow, Matthias; Slutsky, Arthur S

    2013-05-01

    Acute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator induced lung injury (VILI). We investigated the effects of a low tidal volume (V(T)) strategy (V(T) ≈ 3 ml/kg/predicted body weight [PBW]) using pumpless extracorporeal lung assist in established ARDS. Seventy-nine patients were enrolled after a 'stabilization period' (24 h with optimized therapy and high PEEP). They were randomly assigned to receive a low V(T) ventilation (≈3 ml/kg) combined with extracorporeal CO2 elimination, or to a ARDSNet strategy (≈6 ml/kg) without the extracorporeal device. The primary outcome was the 28-days and 60-days ventilator-free days (VFD). Secondary outcome parameters were respiratory mechanics, gas exchange, analgesic/sedation use, complications and hospital mortality. Ventilation with very low V(T)'s was easy to implement with extracorporeal CO2-removal. VFD's within 60 days were not different between the study group (33.2 ± 20) and the control group (29.2 ± 21, p = 0.469), but in more hypoxemic patients (PaO2/FIO2 ≤150) a post hoc analysis demonstrated significant improved VFD-60 in study patients (40.9 ± 12.8) compared to control (28.2 ± 16.4, p = 0.033). The mortality rate was low (16.5%) and did not differ between groups. The use of very low V(T) combined with extracorporeal CO2 removal has the potential to further reduce VILI compared with a 'normal' lung protective management. Whether this strategy will improve survival in ARDS patients remains to be determined (Clinical trials NCT 00538928).

  19. Conservative fluid management prevents age-associated ventilator induced mortality.

    PubMed

    Herbert, Joseph A; Valentine, Michael S; Saravanan, Nivi; Schneck, Matthew B; Pidaparti, Ramana; Fowler, Alpha A; Reynolds, Angela M; Heise, Rebecca L

    2016-08-01

    Approximately 800 thousand patients require mechanical ventilation in the United States annually with an in-hospital mortality rate of over 30%. The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and in-hospital mortality rates. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress patients, but to date there has been no investigation of the effect of conservative fluid management on VILI and ventilator associated mortality rates. We hypothesized that age-associated increases in susceptibility and incidence of pulmonary edema strongly promote age-related increases in ventilator associated mortality. 2month old and 20month old male C57BL6 mice were mechanically ventilated with either high tidal volume (HVT) or low tidal volume (LVT) for up to 4h with either liberal or conservative fluid support. During ventilation, lung compliance, total lung capacity, and hysteresis curves were quantified. Following ventilation, bronchoalveolar lavage fluid was analyzed for total protein content and inflammatory cell infiltration. Wet to dry ratios were used to directly measure edema in excised lungs. Lung histology was performed to quantify alveolar barrier damage/destruction. Age matched non-ventilated mice were used as controls. At 4h, both advanced age and HVT ventilation significantly increased markers of inflammation and injury, degraded pulmonary mechanics, and decreased survival rates. Conservative fluid support significantly diminished pulmonary edema and improved pulmonary mechanics by 1h in advanced age HVT subjects. In 4h ventilations, conservative fluid support significantly diminished pulmonary edema, improved lung mechanics, and resulted in significantly lower mortality rates in

  20. Conservative Fluid Management Prevents Age-Associated Ventilator Induced Mortality

    PubMed Central

    Herbert, Joseph A.; Valentine, Michael S.; Saravanan, Nivi; Schneck, Matthew B.; Pidaparti, Ramana; Fowler, Alpha A.; Reynolds, Angela M.; Heise, Rebecca L.

    2017-01-01

    Background Approximately 800 thousand patients require mechanical ventilation in the United States annually with an in-hospital mortality rate of over 30%. The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and in-hosptial mortality rates. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress patients, but to date there has been no investigation of the effect of conservative fluid management on VILI and ventilator associated mortality rates. We hypothesized that age-associated increases in susceptibility and incidence of pulmonary edema strongly promote age-related increases in ventilator associated mortality. Methods 2 month old and 20 month old male C57BL6 mice were mechanically ventilated with either high tidal volume (HVT) or low tidal volume (LVT) for up to 4 hours with either liberal or conservative fluid support. During ventilation, lung compliance, total lung capacity, and hysteresis curves were quantified. Following ventilation, bronchoalveolar lavage fluid was analyzed for total protein content and inflammatory cell infiltration. Wet to dry ratios were used to directly measure edema in excised lungs. Lung histology was performed to quantify alveolar barrier damage/destruction. Age matched non-ventilated mice were used as controls. Results At 4hrs, both advanced age and HVT ventilation significantly increased markers of inflammation and injury, degraded pulmonary mechanics, and decreased survival rates. Conservative fluid support significantly diminished pulmonary edema and improved pulmonary mechanics by 1hr in advanced age HVT subjects. In 4hr ventilations, conservative fluid support significantly diminished pulmonary edema, improved lung mechanics, and resulted in

  1. Influence of mechanical ventilation and sepsis on redox balance in diaphragm, myocardium, limb muscles, and lungs.

    PubMed

    Chacon-Cabrera, Alba; Rojas, Yeny; Martínez-Caro, Leticia; Vila-Ubach, Monica; Nin, Nicolas; Ferruelo, Antonio; Esteban, Andrés; Lorente, José A; Barreiro, Esther

    2014-12-01

    Mechanical ventilation (MV), using high tidal volumes (V(T)), causes lung (ventilator-induced lung injury [VILI]) and distant organ injury. Additionally, sepsis is characterized by increased oxidative stress. We tested whether MV is associated with enhanced oxidative stress in sepsis, the commonest underlying condition in clinical acute lung injury. Protein carbonylation and nitration, antioxidants, and inflammation (immunoblotting) were evaluated in diaphragm, gastrocnemius, soleus, myocardium, and lungs of nonseptic and septic (cecal ligation and puncture 24 hours before MV) rats undergoing MV (n = 7 per group) for 150 minutes using 3 different strategies (low V(T) [V(T) = 9 mL/kg], moderate V(T) [V(T) = 15 mL/kg], and high V(T) [V(T) = 25 mL/kg]) and in nonventilated control animals. Compared with nonventilated control animals, in septic and nonseptic rodents (1) diaphragms, limb muscles, and myocardium of high-V(T) rats exhibited a decrease in protein oxidation and nitration levels, (2) antioxidant levels followed a specific fiber-type distribution in slow- and fast-twitch muscles, (3) tumor necrosis factor α (TNF-α) levels were higher in respiratory and limb muscles, whereas no differences were observed in myocardium, and (4) in lungs, protein oxidation was increased, antioxidants were rather decreased, and TNF-α remained unmodified. In this model of VILI, oxidative stress does not occur in distant organs or skeletal muscles of rodents after several hours of MV with moderate-to-high V(T), whereas protein oxidation levels were increased in the lungs of the animals. Inflammatory events were moderately expressed in skeletal muscles and lungs of the MV rats. Concomitant sepsis did not strongly affect the MV-induced effects on muscles, myocardium, or lungs in the rodents.

  2. Optimal plateau pressure for patients with acute respiratory distress syndrome: a protocol for a systematic review and meta-analysis with meta-regression.

    PubMed

    Yasuda, Hideto; Nishimura, Tetsuro; Kamo, Tetsuro; Sanui, Masamitsu; Nango, Eishu; Abe, Takayuki; Takebayashi, Toru; Lefor, Alan Kawarai; Hashimoto, Satoru

    2017-05-29

    Lower tidal volume ventilation in patients with acute respiratory distress syndrome (ARDS) is a strategy to reduce the plateau pressure and driving pressure to limit ventilator-induced lung injury (VILI). Several randomised controlled trials (RCTs) and meta-analyses showed that limiting both the plateau pressure and the tidal volume decreased mortality, but the optimal plateau pressure to demonstrate a benefit is uncertain. The aim of this systematic review is to investigate the optimal upper limit of plateau pressure in patients with ARDS to prevent VILI and improve clinical outcomes using meta-analysis with and without meta-regression. RCTs comparing two mechanical ventilation strategies will be included, with lower plateau pressure and with higher plateau pressure, among patients with ARDS and acute lung injury. Data sources include MEDLINE via the NCBI Entrez system, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and Ichushi, a database of papers in Japanese. Two of three physicians will independently screen trials obtained by search for eligibility, and extract data from included studies onto standardised data recording forms. For each included trial, the risk of bias and the quality of evidence will be evaluated using the Grading of Recommendation Assessment Development and Evaluation system. This study does not require ethical approval. The results of this systematic review and meta-analysis with and without meta-regression will be disseminated through conference presentation and publication in a peer-reviewed journal. CRD42016041924. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Nicotinamide Exacerbates Hypoxemia in Ventilator-Induced Lung Injury Independent of Neutrophil Infiltration

    PubMed Central

    Jones, Heather D.; Yoo, Jeena; Crother, Timothy R.; Kyme, Pierre; Ben-Shlomo, Anat; Khalafi, Ramtin; Tseng, Ching W.; Parks, William C.; Arditi, Moshe

    2015-01-01

    Background Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3) directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury. Methods We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts, protein, and cytokine levels. We also measured expression of nicotinamide phosophoribosyltransferase, and its downstream effectors Sirt1 and Cebpa, Cebpb, Cebpe. We assessed the effect of nicotinamide on the production of nitric oxide during ventilator-induced lung injury. We also studied the effects of ventilator-induced lung injury in mice deficient in C/EBPε. Results Nicotinamide treatment significantly inhibited neutrophil infiltration into the lungs during ventilator-induced lung injury, but did not affect protein leakage or cytokine production. Surprisingly, mice treated with nicotinamide developed significantly worse hypoxemia during mechanical ventilation. This effect was not linked to increases in nitric oxide production or alterations in expression of Nicotinamide phosphoribosyl transferase, Sirt1, or Cebpa and Cebpb. Cebpe mRNA levels were decreased with either nicotinamide treatment or mechanical ventilation, but mice lacking C/EBPε developed the same degree of hypoxemia and ventilator-induced lung injury as wild-type mice. Conclusions Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but

  4. Chiral symmetry and density waves in quark matter

    SciTech Connect

    Nakano, E.; Tatsumi, T.

    2005-06-01

    A density wave in quark matter is discussed at finite temperature, which occurs along with the chiral condensation, and is described by a dual standing wave in scalar and pseudoscalar condensates on the chiral circle. The mechanism is quite similar to that for the spin density wave suggested by Overhauser and entirely reflects many-body effects. It is found within a mean-field approximation for the Nambu-Jona-Lasinio model that the chiral-condensed phase with the density wave develops at a high-density region just outside the usual chiral-transition line in phase diagram. A magnetic property of the density wave is also elucidated.

  5. Universal current fluctuations in the symmetric exclusion process and other diffusive systems

    NASA Astrophysics Data System (ADS)

    Akkermans, Eric; Bodineau, Thierry; Derrida, Bernard; Shpielberg, Ohad

    2013-07-01

    Using the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim, one can show that the statistics of the current of the symmetric simple exclusion process (SSEP) connected to two reservoirs on an arbitrary large finite domain in dimension d are the same as in the one-dimensional case. Numerical results on squares support this claim while results on cubes exhibit some discrepancy. We argue that the results of the macroscopic fluctuation theory should be recovered by increasing the size of the contacts. The generalization to other diffusive systems is straightforward.

  6. Universal cumulants of the current in diffusive systems on a ring

    NASA Astrophysics Data System (ADS)

    Appert-Rolland, C.; Derrida, B.; Lecomte, V.; van Wijland, F.

    2008-08-01

    We calculate exactly the first cumulants of the integrated current and of the activity (which is the total number of changes of configurations) of the symmetric simple exclusion process on a ring with periodic boundary conditions. Our results indicate that for large system sizes the large deviation functions of the current and of the activity take a universal scaling form, with the same scaling function for both quantities. This scaling function can be understood either by an analysis of Bethe ansatz equations or in terms of a theory based on fluctuating hydrodynamics or on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim.

  7. Universal cumulants of the current in diffusive systems on a ring.

    PubMed

    Appert-Rolland, C; Derrida, B; Lecomte, V; van Wijland, F

    2008-08-01

    We calculate exactly the first cumulants of the integrated current and of the activity (which is the total number of changes of configurations) of the symmetric simple exclusion process on a ring with periodic boundary conditions. Our results indicate that for large system sizes the large deviation functions of the current and of the activity take a universal scaling form, with the same scaling function for both quantities. This scaling function can be understood either by an analysis of Bethe ansatz equations or in terms of a theory based on fluctuating hydrodynamics or on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim.

  8. Human Operator Modeling for Aerial Tracking.

    DTIC Science & Technology

    1980-12-01

    HUMAN OPERATOR MODELING FOR AERIAL TRACKING JONA THAN KORN ARTER. EPHRATH DA VLD L. KLEINMAN DBCXMBt 19MDTICSELECTE APR 3 1981.j B Approwd for pVA& u...8217the "Guid 8en th Cart end Use of laboratory Animals, "Inatitate of Laboratory Animl ReaNuWAes, National Rtesarch CouncL The voluntary Infomed consent...Continue. on reverse aide If necessary and identify hc block numbrh) ._Modern Optimal Control techniques are e:iployed to investigate and model human

  9. Chiral phase transition from string theory.

    PubMed

    Parnachev, Andrei; Sahakyan, David A

    2006-09-15

    The low energy dynamics of a certain D-brane configuration in string theory is described at weak t'Hooft coupling by a nonlocal version of the Nambu-Jona-Lasinio model. We study this system at finite temperature and strong t'Hooft coupling, using the string theory dual. We show that for sufficiently low temperatures chiral symmetry is broken, while for temperatures larger then the critical value, it gets restored. We compute the latent heat and observe that the phase transition is of the first order.

  10. Transport theory with self-consistent confinement related to the lattice data

    NASA Astrophysics Data System (ADS)

    Bożek, P.; He, Y. B.; Hüfner, J.

    1998-06-01

    The space-time development of a quark-gluon plasma is calculated from a Vlasov equation for the distribution function of quasiparticles with medium dependent masses. At each space-time point the masses are calculated self-consistently from a gap equation, whose form is determined by the requirement that in thermal equilibrium and for a range of temperatures the energy density of the quasiparticle system is identical to the one from lattice calculations. The numerical solutions of the Vlasov equation display confinement. Relations to effective theories like that by Friedberg and Lee and Nambu and Jona-Lasinio are established.

  11. Disorder and Quantum Chromodynamics -- Non-Linear σ Models

    NASA Astrophysics Data System (ADS)

    Guhr, Thomas; Wilke, Thomas

    2001-10-01

    The statistical properties of Quantum Chromodynamics (QCD) show universal features which can be modeled by random matrices. This has been established in detailed analyses of data from lattice gauge calculations. Moreover, systematic deviations were found which link QCD to disordered systems in condensed matter physics. To furnish these empirical findings with analytical arguments, we apply and extend the methods developed in disordered systems to construct a non-linear σ model for the spectral correlations in QCD. Our goal is to derive connections to other low-energy effective theories, such as the Nambu-Jona-Lasinio model, and to chiral perturbation theory.

  12. Disorder and Quantum Chromodynamics - Non-Linear σ Models

    NASA Astrophysics Data System (ADS)

    Guhr, Thomas; Wilke, Thomas

    The statistical properties of Quantum Chromodynamics (QCD) show universal features which can be modeled by random matrices. This has been established in detailed analyses of data from lattice gauge calculations. Moreover, systematic deviations were found which link QCD to disordered systems in condensed matter physics. To furnish these empirical findings with analytical arguments, we apply and extend the methods developed in disordered systems to construct a non-linear σ model for the spectral correlations in QCD. Our goal is to derive connections to other low-energy effective theories, such as the Nambu-Jona-Lasinio model, and to chiral perturbation theory.

  13. A transformational model for the practice of professional nursing. Part 2, Implementation of the model.

    PubMed

    Wolf, G A; Boland, S; Aukerman, M

    1994-05-01

    Our healthcare system is undergoing major transformation. Most nurse executives are convinced that change is necessary and inevitable, but they are less certain how to position their departments for future success. The Transformational Model for the Practice of Professional Nursing was developed as a "road map" for that purpose. Part 1 (JONA, April 1994) discussed the professional practice paradigm shifts that are needed for future success. The model components were presented and applications identified. Part 2 discusses the implementation of this model in a practice setting.

  14. A transformational model for the practice of professional nursing. Part 1, The model.

    PubMed

    Wolf, G A; Boland, S; Aukerman, M

    1994-04-01

    Our healthcare system is undergoing major transformation. Most nurse executives know that change is necessary and inevitable, but are less certain how to position their departments for these changes. The Transformational Model for the Practice of Professional Nursing was developed as a "road map" for that purpose. Part 1 of the model discusses the paradigm shifts that need to occur in professional practice for future success. The various components of the model are presented, and applications are identified. Part 2 will appear in the May 1994 issue of JONA, and will discuss the implementation of this model into a practice setting.

  15. On properties of low-lying spin-1 hadron resonances

    NASA Astrophysics Data System (ADS)

    Chizhov, M. V.

    2017-03-01

    Properties of low-lying spin-1 hadron resonances are described in the review. It is shown how the Nambu-Jona-Lasinio model can be extended in the chiral invariant way by new tensor interactions. New mass formulas are obtained, which are not based on unitary symmetry groups but involve particles from different multiplets even with opposite parity. They all are in good agreement with experimental data. Dynamic properties of spin-1 mesons confirmed by the calculations performed using the QCD sum rule technique and the lattice calculations are understood and explained.

  16. Magnetic catalysis and inverse magnetic catalysis in nonlocal chiral quark models

    NASA Astrophysics Data System (ADS)

    Pagura, V. P.; Gómez Dumm, D.; Noguera, S.; Scoccola, N. N.

    2017-02-01

    We study the behavior of strongly interacting matter under an external constant magnetic field in the context of nonlocal chiral quark models within the mean field approximation. We find that at zero temperature the behavior of the quark condensates shows the expected magnetic catalysis effect, our predictions being in good quantitative agreement with lattice QCD results. On the other hand, in contrast to what happens in the standard local Nambu-Jona-Lasinio model, when the analysis is extended to the case of finite temperature, our results show that nonlocal models naturally lead to the inverse magnetic catalysis effect.

  17. Effects of chiral imbalance and magnetic field on pion superfluidity and color superconductivity

    NASA Astrophysics Data System (ADS)

    Cao, Gaoqing; Zhuang, Pengfei

    2015-11-01

    The effects of chiral imbalance and external magnetic field on pion superfluidity and color superconductivity are investigated in extended Nambu-Jona-Lasinio models. We take the Schwinger approach to treat the interaction between the charged pion condensate and magnetic field at finite isospin density and include simultaneously the chiral imbalance and magnetic field at finite baryon density. For the superfluidity, the chiral imbalance and magnetic field lead to catalysis and inverse catalysis effects, respectively. For the superconductivity, the chiral imbalance enhances the critical baryon density, and the magnetic field results in a de Haas-van Alphan oscillation on the phase transition line.

  18. [Moral aspects of human cloning and relations between humans].

    PubMed

    Lukow, P

    2001-01-01

    It is usually assumed that there is a strong logical relationship between traditional worldviews and attitudes towards human cloning. I argue that the association is contingent, which can be seen in the analysis of arguments of such leading bioethicists as G. J. Annas, H. Jonas, and J. A. Robertson. Traditional worldviews lack conceptual resources that would enable them to provide normative conclusions about cloning. It is therefore mistake to look to these traditional worldviews in search for moral instruction. Instead, one should appeal to knowledge of psychological and social aspects of human life, and in particular to the process of emotional ties which form relations between humans.

  19. Air Force Academy Aeronautics Digest - Spring/Summer 1981.

    DTIC Science & Technology

    1981-12-01

    AD-A112 421 AIR FORCE ACADEMY Co F/S PO/I4 AIR FORCE ACADEMY XERONAUTICS DIGEST -SPRING/SUMMER 1981.(U) DEC 81 A M HIGGINS. F M JONAS. E J JUMPER...RESOLUTION. IEST CHART USAFA-TR-8 1-11 SAIR FORCE ACADEMY ’ Aeronautics Digest - Spring/Summer 1981 RADIAL TURBOJET - He.S. 1 b DECEMBER 1981 C Final...is no objection to unlimited distribution of the Digest to the public at large, or by DDC to the National Technical Information Service. This Digest

  20. Chiral transformations of spin-1 mesons in the non-symmetric vacuum

    NASA Astrophysics Data System (ADS)

    Osipov, A. A.; Volkov, M. K.

    2017-07-01

    A new sort of chiral transformations for spin-1 states is obtained as a result of a linearized diagonalization of πa1 mixing in the effective meson Lagrangian. Using this symmetry argument, we argue that there is no physical distinction between such theory and the theory in which a covariant nonlinear diagonalization is used instead. As an illuminating example, the Nambu-Jona-Lasinio type model with the broken SU(2) × SU(2) chiral symmetry in the one-quark-loop approximation is considered.

  1. Magnet hospitals: Part II. Institutions of excellence.

    PubMed

    Kramer, M; Schmalenberg, C

    1988-02-01

    The oft repeated charge today is to "focus on those who are succeeding!" That's what this report does. Using the eight characteristics identified by Peters and Waterman in their book In Search of Excellence, the study analyzes 16 magnet hospitals to ascertain to what extent they possess characteristics similar to the 'best run' companies in the corporate community. The authors suggest that these magnet hospitals may be dealing effectively with the nursing shortage by creating organizational conditions conducive to eliminating internal nurse shortage. Part I of this article appeared the January 1988 issue of JONA.

  2. [Crisis in medical ethics].

    PubMed

    Stellamor, K

    1996-01-01

    There is a disproportion between diagnostic and therapeutic medical achievements and the doctor/patient relationship. Are we allowed to do everything we are able to do in medicine? People are concerned and worried (genetic technology, invasive medicine, embryos in test tubes etc.). The crisis of ethics in medicine is evident. The analysis of the situation shows one of the causes in the shift of the paradigma-modern times to postmodern following scientific positivism-but also a loss of ethics in medicine due to an extreme secularism and to modern philosophical trends (Hans Jonas and the responsibility for the future and on the other hand modern utilitarism).

  3. Guidelines for the Selection of Chemical Protective Clothing. Volume 2. Technical and Reference Manual.

    DTIC Science & Technology

    1987-02-01

    Modified Polymer Films V. Permeation and Diffusion of Helium, Nitrogen, Methane Ethane, and Propane through gamma-Ray Crosslinked Polyethylene J. Appl...Benzene and by Tritiated Water Am. Ind. Hyg. Assoc. J., 43, pp. 201-211 (1982) 328 Weitzman, D., and L.C. Jonas Industrial Hygiene Program for Hazardous...30. 253 3.10 -9.00 0. 253 1.25 -9.00 -8. 253 IsopropyLni ne 000753100 PV ACETATE 124 NK 1.70 -12.00 40. 178 Methane 000748280 PE 048 LINK 1.96 -7.0 25

  4. Ice limit of Coulomb gauge Yang-Mills theory

    SciTech Connect

    Heinzl, T.; Ilderton, A.; Langfeld, K.; Lavelle, M.; McMullan, D.

    2008-10-01

    In this paper we describe gauge invariant multiquark states generalizing the path integral framework developed by Parrinello, Jona-Lasinio, and Zwanziger to amend the Faddeev-Popov approach. This allows us to produce states such that, in a limit which we call the ice limit, fermions are dressed with glue exclusively from the fundamental modular region associated with Coulomb gauge. The limit can be taken analytically without difficulties, avoiding the Gribov problem. This is illustrated by an unambiguous construction of gauge invariant mesonic states for which we simulate the static quark-antiquark potential.

  5. FDA advisory committees meet January 26 on Salk HIV-1 immunogen.

    PubMed

    1995-01-06

    Two advisory committees of the Food and Drug Administration (FDA) will meet to consider future trials of the HIV-1 immunogen developed by Dr. Jonas Salk. The Immune Response Corporation has already conducted several studies of the immunogen, and has found improvement in various immunological and other blood tests, and no adverse effects. However, the studies have not been large enough to show conclusively that the treatment has clinical benefit in delaying disease progression. The new, larger trials are intended to demonstrate a delay in disease progression and validate the use of blood-test markers of disease progression for studying an immune-based treatment.

  6. [Historical development of vaccines. Introduction: Hazards and rationality in the vaccinal approach].

    PubMed

    Moulin, A M

    1995-01-01

    The aim of this paper is to introduce the one hundred years of vaccination that has passed since Louis Pasteur first coined this generic term. According to the late Jonas Salk, vaccinology is a science encompassing all aspects of vaccine from its conception in the laboratory to its production by companies and its application and distribution in the field. In this historical survey I explore how vaccination never consisted of a simple and uniform application of a rational model, but rather diverged along various pathways, several of which were discarded in retrospect as being hazardous, and I analyse the ongoing interplay between rational and inventive thinking.

  7. Constantin Levaditi (1874-1953): a pioneer in Immunology and Virology.

    PubMed

    Kalantzis, George; Skiadas, Panagiotis; Lascaratos, John

    2006-08-01

    The eminent doctor Constantin Levaditi represents one of the most important researchers in the field of medicine in the 20th century. Although he was engaged in many areas of the rapidly growing field of immunology, his name is associated mainly with research in poliomyelitis. His laboratory research contributed decisively to the clarification of the epidemiology of this dreadful disease that claimed thousands of victims. Moreover, his experimental work constituted the basis for the development of the vaccine against poliomyelitis, initially in 1955 by Jonas Salk (1914-95) using inactivated virus, and then in 1960 by Albert Sabin (1906-93) who used live attenuated virus.

  8. Agouron and immune response to commercialize remune immune-based treatment.

    PubMed

    James, J S

    1998-06-19

    Agouron Pharmaceuticals agreed in June to collaborate with The Immune Response Corporation on the final development and marketing of an immune-based treatment for HIV. Remune, the vaccine developed by Dr. Jonas Salk, is currently in Phase III randomized trials with 2,500 patients, and the trials are expected to be completed in April 1999. Immune-based treatments have been difficult to test, as there is no surrogate marker, like viral load, to determine if the drug is working. Agouron agreed to participate in the joint venture after reviewing encouraging results from preliminary trials in which remune was taken in combination with highly active antiretroviral drugs.

  9. Pion and kaon condensations in three-flavor random matrix theory

    SciTech Connect

    Arai, Ryoichi; Yoshinaga, Naotaka

    2008-11-01

    We study the QCD phase structure in a three-flavor random matrix model with symmetries of QCD formulated at finite temperature and nonzero chemical potentials of baryon number, isospin, and strangeness. We numerically investigate the phase diagram in the chemical potential plane at zero temperature with finite quark masses. We find a rich phase structure separated by both first and second order phase transition lines, which qualitatively agrees with the predictions of effective chiral models and Nambu-Jona-Lasinio models. The phases are characterized by the chiral condensates of three flavors, pion and kaon condensates.

  10. Effect of discrete quark momenta on the Goldstone mode in a magnetic field

    NASA Astrophysics Data System (ADS)

    Mao, Shijun; Wang, Yuxuan

    2017-08-01

    The meson static properties are investigated in a Pauli-Villars regularized Nambu-Jona-Lasinio model in a strong magnetic field. The quark dimension reduction leads to a sudden jump of the mass of the Goldstone mode at the Mott transition temperature. A consequence of such a jump may be some interesting phenomena in relativistic heavy ion collisions, where the strong magnetic field can be created. For instance, when the formed fireball cools down, there might be a sudden enhancement of neutral pions at the Mott transition temperature.

  11. Responses of quark condensates to the chemical potential

    NASA Astrophysics Data System (ADS)

    Miyamura, O.; Choe, S.; Liu, Y.; Takaishi, T.; Nakamura, A.

    2002-10-01

    The responses of quark condensates to the chemical potential, as a function of temperature T and chemical potential μ, are calculated within the Nambu-Jona-Lasinio (NJL) model. We compare our results with those from the recent lattice QCD simulations [QCD-TARO Collaboration, S. Choe et al., Nucl. Phys. B (Proc. Suppl.) 106, 462 (2002)]. The NJL model and lattice calculations show qualitatively similar behavior, and they will be complimentary ways to study hadrons at finite density. The behavior above Tc requires more elaborated analyses.

  12. I think they're doing research on my patients, but I can't get anyone to listen.

    PubMed

    Jackson, B S; Ramsey, G C; Sidel, V W; Powderly, K E

    1998-10-01

    JONA's Management Case Studies presents provocative issues in nursing management, including personnel management, ethics, labor relations, economics, staffing, interdisciplinary relations, and career management. Experts in the field share their perspectives on the issue. Readers are encouraged to submit cases of 250 to 300 words. The case may be based on factual information but should be altered to make individuals and institutions unidentifiable. Authors of cases will not be identified although they will be offered the opportunity to be one of the expert case commentators.

  13. Magnetic-field induced critical endpoint

    NASA Astrophysics Data System (ADS)

    Rechenberger, Stefan

    2017-03-01

    The phase diagram of strong interaction matter is analyzed utilizing the Nambu-Jona-Lasinio model. Special emphasis is placed on its dependence on an external magnetic field and isospin chemical potential. Using flavor mixing induced by instanton effects the influence of isospin breaking due to the magnetic field and the isospin chemical potential is compared. It is found that at low temperatures and large quark chemical potential the magnetic field, depending on its strength, induces a new critical endpoint or a triple point.

  14. Phase structure in a chiral model of nuclear matter

    SciTech Connect

    Phat, Tran Huu; Anh, Nguyen Tuan; Tam, Dinh Thanh

    2011-08-15

    The phase structure of symmetric nuclear matter in the extended Nambu-Jona-Lasinio (ENJL) model is studied by means of the effective potential in the one-loop approximation. It is found that chiral symmetry gets restored at high nuclear density and a typical first-order phase transition of the liquid-gas transition occurs at zero temperature, T=0, which weakens as T grows and eventually ends up with a second-order critical point at T=20 MeV. This phase transition scenario is confirmed by investigating the evolution of the effective potential versus the effective nucleon mass and the equation of state.

  15. Holograms of a dynamical top quark

    NASA Astrophysics Data System (ADS)

    Clemens, Will; Evans, Nick; Scott, Marc

    2017-09-01

    We present holographic descriptions of dynamical electroweak symmetry breaking models that incorporate the top mass generation mechanism. The models allow computation of the spectrum in the presence of large anomalous dimensions due to walking and strong Nambu-Jona-Lasinio interactions. Technicolor and QCD dynamics are described by the bottom-up Dynamic AdS/QCD model for arbitrary gauge groups and numbers of quark flavors. An assumption about the running of the anomalous dimension of the quark bilinear operator is input, and the model then predicts the spectrum and decay constants for the mesons. We add Nambu-Jona-Lasinio interactions responsible for flavor physics from extended technicolor, top-color, etc., using Witten's multitrace prescription. We show the key behaviors of a top condensation model can be reproduced. We study generation of the top mass in (walking) one doublet and one family technicolor models and with strong extended technicolor interactions. The models clearly reveal the tensions between the large top mass and precision data for δ ρ . The necessary tunings needed to generate a model compatible with precision constraints are simply demonstrated.

  16. Food marketing targeting children: unveiling the ethical perspectives in the discourse on self-regulation.

    PubMed

    Silva, Dillian Adelaine Cesar da; Cunha, Antonio Carlos Rodrigues da; Cunha, Thiago Rocha da; Rosaneli, Caroline Filla

    2017-07-01

    When it comes to food marketing, children are one of the major targets. Regulatory actions can play a strategic role in health protection. The objective of this research was to characterize the ethical perspective in the discourse against state regulatory actions on food marketing directed at children, aiming to understand the context of the discourse's production and how it creates meaning. The methodology adopted was qualitative, with documentary analysis and use of concepts and procedures from Discourse Analysis. The work of Hans Jonas, specifically his Responsibility Principle, and Garrafa and Port's Intervention Bioethics oriented the analysis. The self-regulation discourse analysis showed an ethical perspective in which relations of consumption predominate over the children´s vulnerability. The rhetorical excess is constant, as well as the use of resources like naturalization, untruthfulness, ideological dissimulation and euphemism. An erasure of social conflicts takes place, and an ahistorical perspective is present. The discourse does not align with Jonas´ Responsibility Principle, nor those of Intervention Bioethics. Lastly, the ethical perspective of the discourse represents a double paradox, because it is a business discourse that hides its competitive roots and metamorphoses into an ethical one.

  17. [Bioethical principles in public health: limitations and proposals].

    PubMed

    Schramm, F R; Kottow, M

    2001-01-01

    We propose to analyze the specificity of ethical problems in public health issues and to elucidate the applicability of principlism as a problem-solving strategy in this realm. Although well-established in clinical ethics, principlism is not an adequate model to be used in public health, since it is basically intended to serve as a moral guide in the physician-patient encounter. We discuss the possible adequacy of principles like "solidarity", "ontic responsibility" (as proposed by Jonas), and "caring or diaconal responsibility" as presented by Lévinas. Solidarity appears to be insufficiently specified, whereas the other two perspectives may be adapted to public health issues by bringing together Jonas' ontological and Lévinas' transcendental concerns to form a principle of protection that might better serve the purposes of such an ethics. This principle would help to identify more clearly the goals and agents involved in the implementation of public policies that are expected to be both morally correct and pragmatically effective.

  18. Quark fragmentation functions in NJL-jet model

    NASA Astrophysics Data System (ADS)

    Bentz, Wolfgang; Matevosyan, Hrayr; Thomas, Anthony

    2014-09-01

    We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. Supported by Grant in Aid for Scientific Research, Japanese Ministry of Education, Culture, Sports, Science and Technology, Project No. 20168769.

  19. Possible formation of high temperature superconductor at an early stage of heavy-ion collisions

    NASA Astrophysics Data System (ADS)

    Liu, Hao; Yu, Lang; Chernodub, Maxim; Huang, Mei

    2016-12-01

    We investigate the effect of the inverse magnetic catalysis (IMC) on charged ρ meson condensation at finite temperature in the framework of the Nambu-Jona-Lasinio model, where mesons are calculated to the leading order of 1 /Nc expansion. The IMC for chiral condensate has been considered using three different approaches: incorporating the chiral condensate from lattice data, using the running coupling constant, and introducing the chiral chemical potential, respectively. It is observed that with no IMC effect included, the critical magnetic field e Bc for charged ρ condensation increases monotonically with the temperature. However, including IMC substantially affects the polarized charged ρ condensation around the critical temperature Tc of the chiral phase transition: first, the critical magnetic field e Bc for the charged ρ condensation decreases with the temperature, reaches its minimum value around Tc, and then increases with the temperature. It is quite surprising that the charged ρ can condense above the critical temperature of chiral phase transition with a even smaller critical magnetic field comparing its vacuum value. The Nambu-Jona-Lasinio model calculation shows that in the temperature region of 1 - 1.5 Tc , the critical magnetic field for charged ρ condensation is rather small and in the region of e Bc˜0.15 - 0.3 GeV2 , which suggests that high temperature superconductor might be created through noncentral heavy ion collisions at LHC energies.

  20. Critical end point in the presence of a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Cui, Z.-F.; Cloët, I. C.; Lu, Y.; Roberts, C. D.; Schmidt, S. M.; Xu, S.-S.; Zong, H.-S.

    2016-10-01

    A class of Polyakov-loop-modified Nambu-Jona-Lasinio models has been used to support a conjecture that numerical simulations of lattice-regularized QCD defined with a chiral chemical potential can provide information about the existence and location of a critical end point in the QCD phase diagram drawn in the plane spanned by baryon chemical potential and temperature. That conjecture is challenged by conflicts between the model results and analyses of the same problem using simulations of lattice-regularized QCD (lQCD) and well-constrained Dyson-Schwinger equation (DSE) studies. We find the conflict is resolved in favor of the lQCD and DSE predictions when both a physically motivated regularization is employed to suppress the contribution of high-momentum quark modes in the definition of the effective potential connected with the Polyakov-loop-modified Nambu-Jona-Lasinio models and the four-fermion coupling in those models does not react strongly to changes in the mean field that is assumed to mock-up Polyakov-loop dynamics. With the lQCD and DSE predictions thus confirmed, it seems unlikely that simulations of lQCD with μ5>0 can shed any light on a critical end point in the regular QCD phase diagram.

  1. A revision of Pheidole Westwood (Hymenoptera: Formicidae) in the islands of the southwest Indian Ocean and designation of a neotype for the invasive Pheidole megacephala.

    PubMed

    Fischer, G; Fisher, B L

    2013-01-01

    The myrmicine genus Pheidole Westwood is revised for the smaller islands of the Southwest Indian Ocean: Comoros, Juan de Nova Island, Mauritius, Mayotte, Reunion, and the Seychelles. Descriptions and keys are provided for the thirteen species on these islands of which seven are newly described: P. decepticon sp. n., P. dodo sp. n., P. komori sp. n, P. loki sp. n., P. megatron sp. n., P. ragnax sp. n., P. vulcan sp. n.; and six were previously described: P. braueri Forel, P. fervens Smith, F., P. jonas Forel, P. megacephala (Fabricius), P. parva Forel, and P. teneriffana Forel. New synonymies (with the senior synonym listed first) include P. parva Mayr = P. flavens var. farquharensis Forel, P. parva Mayr = P. tarda Donisthorpe, P. megacephala (Fabricius) = P. picata Forel, P. megacephala (Fabricius) = P. punctulata r. gietleni Forel, 1905, P. megacephala (Fabricius) = P. picata var. bernhardae Emery, 1915, P. megacephala (Fabricius) = P megacephala r. scabrior Forel, and P. teneriffana Forel = P. voeltzkowii Forel. Furthermore, lectotypes are designated from the syntypes of P. braueri, P. fervens, P. jonas, P. parva, and P. teneriffana in order to provide a single name-bearing specimen and to facilitate future taxonomic studies. Finally, a neotype is provided for the untraceable or possibly lost type of the cosmopolitan and invasive P. megacephala, which was originally described by Fabricius from Mauritius (the former 'Ile de France').

  2. Finite-size effects on the hadron-quark phase transition in neutron stars

    NASA Astrophysics Data System (ADS)

    Wu, X. H.; Shen, H.

    2017-08-01

    We study the finite-size effects, like the surface and Coulomb energies, on the hadron-quark mixed phase in neutron stars. The equilibrium conditions for coexisting hadronic and quark phases are derived by minimizing the total energy including the surface and Coulomb contributions, which are different from the Gibbs conditions without finite-size effects. We employ the relativistic mean-field model to describe the hadronic phase, while the Nambu-Jona-Lasinio model with vector interactions is used for the quark phase. It is found that finite-size effects can significantly reduce the region of the mixed phase, and the results lie between those of the Gibbs and Maxwell constructions. We show that a massive star may contain a mixed phase core and its size depends on the surface tension of the hadron-quark interface and the vector coupling between quarks. The repulsive vector interaction in the Nambu-Jona-Lasinio model can stiffen the equation of state of quark matter, and therefore delay the phase transition and increase the maximum mass of neutron stars.

  3. What ecologists can tell virologists.

    PubMed

    Dennehy, John J

    2014-01-01

    I pictured myself as a virus…and tried to sense what it would be like. --Jonas Salk. Ecology as a science evolved from natural history, the observational study of the interactions of plants and animals with each other and their environments. As natural history matured, it became increasingly quantitative, experimental, and taxonomically broad. Focus diversified beyond the Eukarya to include the hidden world of microbial life. Microbes, particularly viruses, were shown to exist in unfathomable numbers, affecting every living organism. Slowly viruses came to be viewed in an ecological context rather than as abstract, disease-causing agents. This shift is exemplified by an increasing tendency to refer to viruses as living organisms instead of inert particles. In recent years, researchers have recognized the critical contributions of viruses to fundamental ecological processes such as biogeochemical cycling, competition, community structuring, and horizontal gene transfer. This review describes virus ecology from a virus's perspective. If we are, like Jonas Salk, to imagine ourselves as a virus, what kind of world would we experience?

  4. Can Genomic Amplification of Human Telomerase Gene and C-MYC in Liquid-Based Cytological Specimens Be Used as a Method for Opportunistic Cervical Cancer Screening?

    PubMed

    Gao, Kun; Eurasian, Menglan; Zhang, Jieqing; Wei, Yuluan; Zheng, Qian; Ye, Hongtao; Li, Li

    2015-01-01

    To evaluate the effectiveness of five methods including the ThinPrep cytological test (TCT), liquid-based cytology, the human papillomavirus (HPV) test, detection of the TERC and C-MYC genes and visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, and to explore whether genomic amplification of the human telomerase gene and C-MYC in liquid-based cytological specimens can be used as a method for opportunistic cervical cancer screening. Data were collected prospectively from 1,010 consecutive patients who visited the gynecology clinic and agreed to participate in opportunistic cervical cancer screening at our institution from November 2010 to July 2011. The five methods mentioned above were used for the screening in all cases. The histopathological diagnosis served as the gold standard for the evaluation. A comparison between the five screening methods for the diagnosis of high-grade cervical intraepithelial neoplasia (CIN II and III) was performed for their sensitivity, specificity, false-positive rate, false-negative rate, accuracy rate, positive likelihood ratio and negative likelihood ratio. A comprehensive comparison of the different combination programs for screening was performed according to the analysis of the receiver operating characteristic (ROC) curve area. The accuracy of the five screening methods for the diagnosis of high-grade CIN (CIN II and III) was compared in the different age groups. A joint model for the diagnosis using different combinations of the five methods was developed according to the analysis by the SAS 8.0 software. The model was used to evaluate the accuracy of the different combination programs for the diagnosis of high-grade CIN, and the results were confirmed by the histopathological examination. The sensitivity and specificity of the single screen method (TCT, HPV test, detection of the TERC and C-MYC genes, and VIA/VILI method) for CIN II was 80.9, 70.2, 72.3, 76.6, and 72

  5. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

    PubMed Central

    2011-01-01

    Background A new lower-cost rapid-throughput human papillomavirus (HPV) test (careHPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. Methods We assessed the outcomes and cost-effectiveness of careHPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; careHPV@1.0 pg/ml and careHPV@0.5 pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for careHPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for careHPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using careHPV@1.0) per LYS. Conclusions This modelled analysis suggests that primary careHPV screening compares

  6. Trials and projects on cervical cancer and human papillomavirus prevention in sub-Saharan Africa.

    PubMed

    Adefuye, Peter O; Broutet, Nathalie J; de Sanjosé, Silvia; Denny, Lynette A

    2013-12-29

    Cervical cancer is the leading cause of cancer morbidity and mortality in women in sub-Saharan Africa (SSA), accounting for about 50,000 deaths annually. Until recently, cytology was the gold standard for screening and prevention of cervical cancer. This method of screening has not been successful in SSA due to a lack of human, financial and material resources and poor health care infrastructure. It is estimated that less than 5% of at risk women have ever being screened. In the past two decades alternative approaches to cytology for cervical cancer screening have been evaluated in low- and medium-income countries. Visual inspection with acetic acid (VIA) and/or Lugol's iodine (VILI) have been shown to have adequate sensitivity, although low specificity, in a number of cross-sectional research and demonstration projects. Visual inspection methods require minimal resources, are technologically accessible, and are feasible for screening for precancerous lesions. Linking screening with VIA/VILI to treatment with cryotherapy may enable screening and treatment to take place in one visit, but this is likely to result in large numbers of women being subjected to unnecessary treatment. A number of studies have shown that cryotherapy is not associated with significant side effects or complications and is well tolerated. Creating the infrastructure for screening of older women is considered desirable, despite the limitations of visual inspection methods as screening tests. Understanding the role of human papillomavirus (HPV) infection in the etiology of cervical cancer and the discovery of HPV rapid test kits, as well as the development of vaccines against the HPV oncogenic types, have created new opportunities for prevention of cervical cancer. Trials and projects have established (and are still ongoing) the feasibility of using these molecular tests for screening. The ultimate in prevention method is primary prevention, offered by the advent of prophylactic vaccines

  7. Early detection of cervical cancer with visual inspection methods: a summary of completed and on-going studies in India.

    PubMed

    Sankaranarayanan, R; Nene, B M; Dinshaw, K; Rajkumar, R; Shastri, S; Wesley, R; Basu, P; Sharma, R; Thara, S; Budukh, A; Parkin, D M

    2003-01-01

    India is a high-risk country for cervical cancer which accounts a quarter (126,000 new cases, 71,000 deaths around 2,000) of the world burden. The age-standardized incidence rates range from 16-55 per 100,000 women in different regions with particularly high rates in rural areas. Control of cervical cancer by early detection and treatment is a priority of the National Cancer Control Programme of India. There are no organized cytology screening programmes in the country. The technical and financial constraints to organize cytology screening have encouraged the evaluation of visual inspection approaches as potential alternatives to cervical cytology in India. Four types of visual detection approaches for cervical neoplasia are investigated in India: a) naked eye inspection without acetic acid application, widely known as 'downstaging'; b) naked eye inspection after application of 3-5% acetic acid (VIA); c) VIA using magnification devices (VIAM); d) visual inspection after the application of Lugol's iodine (VILI). Downstaging has been shown to be poorly sensitive and specific to detect cervical neoplasia and is no longer considered as a suitable screening test for cervical cancer. VIA, VIAM and VILI are currently being investigated in multicentre cross-sectional studies (without verification bias), in which cytology and HPV testing are also simultaneously evaluated, and the results of these investigations will be available in 2003. These studies will provide valuable information on the average, comparative test performances in detecting high-grade cervical cancer precursors and cancer. Results from pooled analysis of data from two completed studies indicated an approximate sensitivity of 93.4% and specificity of 85.1% for VIA to detect CIN 2 or worse lesions; the corresponding figures for cytology were 72.1% and 91.6%. The efficacy of VIA in reducing incidence of an mortality from cervical cancer and its cost-effectiveness is currently being investigated in two

  8. Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats

    PubMed Central

    Loring, Stephen H.; Pecchiari, Matteo; Valle, Patrizia Della; Monaco, Ario; Gentile, Guendalina; D'Angelo, Edgardo

    2014-01-01

    Objective To see whether in acute lung injury (ALI) 1) compression of the lungs caused by thoracoabdominal constriction degrades lung function and worsens ventilator-induced lung injury (VILI), and 2) maintaining end-expiratory transpulmonary pressure (Pl) by increasing positive end-expiratory pressure (PEEP) reduces the deleterious effects of chest wall constriction. Design Experimental study in rats. Setting Physiology laboratory. Interventions ALI was induced in 3 groups of 9 rats by saline lavage. Nine animals immediately sacrificed served as control group. Group L had lavage only, group LC had the chest wall constricted with an elastic binder, and group LCP had the same chest constriction but with PEEP raised to maintain end-expiratory Pl. After lavage, all groups were ventilated with the same pattern for 1½ hr. Measurements and Main Results Pl, measured with an esophageal balloon-catheter, lung volume changes, arterial blood gasses and pH were assessed during mechanical ventilation (MV). Lung wet-to-dry ratio (W/D), albumin, TNF-α, IL-1β, IL-6, IL-10, and MIP-2 in serum and bronchoalveolar lavage fluid (BALF), and serum E-selectin and von Willebrand Factor (vWF) were measured at the end of MV. Lavage caused hypoxemia and acidemia, increased lung resistance and elastance, and decreased end-expiratory lung volume. With prolonged MV, lung mechanics, hypoxemia, and W/D were significantly worse in group LC. Pro-inflammatory cytokines except E-selectin were elevated in serum and BALF in all groups, with significantly greater levels of TNF-α, IL-1β, and IL-6 in group LC, which also exhibited significantly worse bronchiolar injury and greater heterogeneity of airspace expansion at a fixed Pl than other groups. Conclusions Chest wall constriction in ALI reduces lung volume, worsens hypoxemia, and increases pulmonary edema, mechanical abnormalities, pro-inflammatory mediator release, and histological signs of VILI. Maintaining end-expiratory Pl at preconstriction

  9. Burden of cervical cancer and role of screening in India

    PubMed Central

    Bobdey, Saurabh; Sathwara, Jignasa; Jain, Aanchal; Balasubramaniam, Ganesh

    2016-01-01

    Background: Cervical cancer is a major cause of cancer mortality in women and more than a quarter of its global burden is contributed by developing countries. In India, in spite of alarmingly high figures, there is no nationwide government-sponsored screening program. This study was conducted to assess the burden of cervical cancer in India and review the performance characteristics of available cervical cancer screening tools, so as to provide evidence-based recommendations for application of most practically suited screening test to be used in resource-poor field settings. Materials and Methods: MEDLINE and Web of Science electronic database were searched from January 1990 to December 2015, using the keywords such as “cervical cancer”, “screening”, “early detection”, “cervical cytology” and “visual inspection”, and their corresponding MeSH terms in combination with Boolean operators “OR, AND.” Two authors independently selected studies that are published in English and conducted in India. A total of 11 studies were found to be relevant and eligible to be included in the present study. Results: In India, cervical cancer contributes to approximately 6–29% of all cancers in women. The age-adjusted incidence rate of cervical cancer varies widely among registries; highest is 23.07/100,000 in Mizoram state and the lowest is 4.91/100,000 in Dibrugarh district. The pooled estimates of sensitivity and specificity of visual inspection with acetic acid (VIA), magnified VIA, visual inspection with Lugol's iodine (VILI), cytology (Pap smear), and human papillomavirus DNA were found to be 67.65% and 84.32%, 65.36% and 85.76%, 78.27% and 87.10%, 62.11% and 93.51%, and 77.81% and 91.54%, respectively. Conclusions: In developing countries because of lack of necessary infrastructure and quality control, high-quality cytology screening may not be feasible for wide-scale implementation. Hence, cervical cancer screening program based on visual screening test

  10. Critical temperature of chiral symmetry restoration for quark matter with a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.

    2016-12-01

    In this article we study the restoration of chiral symmetry at a finite temperature for quark matter with a chiral chemical potential, {μ }5, by means of a nonlocal Nambu-Jona-Lasinio model. This model allows the introduction of, in the simplest way possible, a Euclidean momentum, p E , dependent quark mass function which decays (neglecting logarithms) as 1/{p}{E}2 for large p E , in agreement with the asymptotic behaviour expected in quantum chromodynamics in the presence of a nonperturbative quark condensate. We focus on the critical temperature for chiral symmetry restoration in the chiral limit, T c, versus {μ }5, as well as on the order of the phase transition. We find that T c increases with {μ }5, and that the transition remains of the second order for the whole range of {μ }5 considered.

  11. Microscopic versus macroscopic approaches to non-equilibrium systems

    NASA Astrophysics Data System (ADS)

    Derrida, Bernard

    2011-01-01

    The one-dimensional symmetric simple exclusion process (SSEP) is one of the very few exactly soluble models of non-equilibrium statistical physics. It describes a system of particles which diffuse with hard core repulsion on a one-dimensional lattice in contact with two reservoirs of particles at unequal densities. The goal of this paper is to review the two main approaches which lead to the exact expression of the large deviation functional of the density of the SSEP in its steady state: a microscopic approach (based on the matrix product ansatz and an additivity property) and a macroscopic approach (based on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio and Landim).

  12. Vector meson condensation in a pion superfluid

    NASA Astrophysics Data System (ADS)

    Brauner, Tomáš; Huang, Xu-Guang

    2016-11-01

    We revisit the suggestion that charged ρ -mesons undergo Bose-Einstein condensation in isospin-rich nuclear matter. Using a simple version of the Nambu-Jona-Lasinio (NJL) model, we conclude that ρ -meson condensation is either avoided or postponed to isospin chemical potentials much higher than the ρ -meson mass as a consequence of the repulsive interaction with the preformed pion condensate. In order to support our numerical results, we work out a linear sigma model for pions and ρ -mesons, showing that the two models lead to similar patterns of medium dependence of meson masses. As a byproduct, we analyze in detail the mapping between the NJL model and the linear sigma model, focusing on conditions that must be satisfied for a quantitative agreement between the models.

  13. Stability of color-flavor-locking cores in hybrid stars

    SciTech Connect

    Pagliara, G.; Schaffner-Bielich, J.

    2008-03-15

    We study the equation of state strongly interacting quark matter within a Nambu-Jona-Lasinio-like model in which the chiral condensates and the color superconducting gaps are computed self-consistently as a function of the baryon density. A vector interaction term is added to the Lagrangian in order to render the quark matter equation of state stiffer. For the low density hadronic phase we use a relativistic mean field model. The phase transition to quark matter is computed by a Maxwell construction. We show that stable color-flavor-locking (CFL) cores in hybrid stars are possible if the superconducting gap is sufficiently large. Moreover we find stable stellar configurations in which two phase transitions occur, a first transition from hadronic matter to 2SC quark matter and a second transition from 2SC quark matter to CFL quark matter.

  14. Spin Polarization in High Density Quark Matter

    NASA Astrophysics Data System (ADS)

    Bohr, Henrik; Panda, Prafulla K.; Providência, Constança; da Providência, João

    2013-04-01

    We investigate the occurrence of a ferromagnetic phase transition in high density hadronic matter (e.g., in the interior of a neutron star). This could be induced by a four-fermion interaction analogous to the one which is responsible for chiral symmetry breaking in the Nambu-Jona-Lasinio model, to which it is related through a Fierz transformation. Flavor SU(2) and flavor SU(3) quark matter are considered. A second-order phase transition is predicted at densities about 5 times the normal nuclear matter density. It is also found that in flavor SU(3) quark matter, a first-order transition from the so-called 2 flavor super-conducting phase to the ferromagnetic phase arises. The color-flavor-locked phase may be completely hidden by the FP.

  15. Nonlocality effects on color spin locking condensates

    SciTech Connect

    Aguilera, D. N.; Blaschke, D.; Grigorian, H.; Scoccola, N. N.

    2006-12-01

    We consider the color spin locking (CSL) phase of two-flavor quark matter at zero temperature for nonlocal instantaneous separable interactions. We employ a Lorentzian-type form factor allowing a parametric interpolation between the sharp [Nambu-Jona-Lasinio (NJL) model] and very smooth (e.g. Gaussian) cutoff models for systematic studies of the influence on the CSL condensate the deviation from the NJL model entails. This smoothing of the NJL model form factor shows advantageous features for the phenomenology of compact stars: (i) a lowering of the critical chemical potential for the onset of the chiral phase transition as a prerequisite for stability of hybrid stars with extended quark matter cores and (ii) a reduction of the smallest pairing gap to the order of 100 keV, being in the range of values interesting for phenomenological studies of hybrid star cooling evolution.

  16. Consistent regularization and renormalization in models with inhomogeneous phases

    NASA Astrophysics Data System (ADS)

    Adhikari, Prabal; Andersen, Jens O.

    2017-02-01

    In many models in condensed matter and high-energy physics, one finds inhomogeneous phases at high density and low temperature. These phases are characterized by a spatially dependent condensate or order parameter. A proper calculation requires that one takes the vacuum fluctuations of the model into account. These fluctuations are ultraviolet divergent and must be regularized. We discuss different ways of consistently regularizing and renormalizing quantum fluctuations, focusing on momentum cutoff, symmetric energy cutoff, and dimensional regularization. We apply these techniques calculating the vacuum energy in the Nambu-Jona-Lasinio model in 1 +1 dimensions in the large-Nc limit and in the 3 +1 dimensional quark-meson model in the mean-field approximation both for a one-dimensional chiral-density wave.

  17. Betti numbers of graded modules and cohomology of vector bundles

    NASA Astrophysics Data System (ADS)

    Eisenbud, David; Schreyer, Frank-Olaf

    2009-07-01

    In the remarkable paper Graded Betti numbers of Cohen-Macaulay modules and the multiplicity conjecture, Mats Boij and Jonas Soederberg conjectured that the Betti table of a Cohen-Macaulay module over a polynomial ring is a positive linear combination of Betti tables of modules with pure resolutions. We prove a strengthened form of their conjectures. Applications include a proof of the Multiplicity Conjecture of Huneke and Srinivasan and a proof of the convexity of a fan naturally associated to the Young lattice. With the same tools we show that the cohomology table of any vector bundle on projective space is a positive rational linear combination of the cohomology tables of what we call supernatural vector bundles. Using this result we give new bounds on the slope of a vector bundle in terms of its cohomology.

  18. Effects of rotation and boundaries on chiral symmetry breaking of relativistic fermions

    NASA Astrophysics Data System (ADS)

    Chernodub, M. N.; Gongyo, Shinya

    2017-05-01

    In order to avoid unphysical causality-violating effects, any rigidly rotating system must be bounded in directions transverse to the axis of rotation. We demonstrate that this requirement implies substantial dependence of properties of the relativistically rotating system on the boundary conditions. We consider a system of interacting fermions described by the Nambu-Jona-Lasinio model in a space bounded by the cylindrical surface of the finite radius. In order to confine the fermions inside the cylinder, we impose "chiral" MIT boundary conditions on its surface. These boundary conditions are parametrized by a continuous chiral angle Θ . We find that, at any value of Θ , the chiral restoration temperature Tc decreases as a quadratic function of the angular frequency Ω . However, the position and the slope of the critical curve Tc=Tc(Ω ) in the phase diagram depend noticeably on the value of the chiral angle.

  19. Multi scale simulation of transport in an open quantum system: Resonances and WKB interpolation

    SciTech Connect

    Abdallah, Naoufel Ben . E-mail: naoufel@mip.ups-tlse.fr; Pinaud, Olivier . E-mail: pinaud@mip.ups-tlse.fr

    2006-03-20

    A numerical scheme for the one-dimensional stationary Schroedinger-Poisson model is described. The scheme is used to simulate a resonant tunneling diode and provides an important reduction of the simulation time. The improvement is twofold. First the grid spacing in the position variable is made coarser by using oscillating interpolation functions derived from the WKB asymptotics. Then the discretization of the energy variable, which is a parameter for the Schroedinger equation, is improved by approaching the wavefunctions in the double barrier region by its projection on the resonant states (following the work of Presilla-Sjoestrand and Jona-Lasinio [On Schroedinger equations with concentrated non-linearities, Ann. Phys. 240 (1995) 1-21])

  20. Magnetized color superconducting quark matter under compact star conditions: Phase structure within the SU(2 ) f NJL model

    NASA Astrophysics Data System (ADS)

    Coppola, M.; Allen, P.; Grunfeld, A. G.; Scoccola, N. N.

    2017-09-01

    The properties of magnetized color superconducting cold dense quark matter under compact star conditions are investigated using an S U (2 )f Nambu Jona-Lasinio (NJL)-type model in which the divergences are treated using a magnetic field independent regularization scheme in order to avoid unphysical oscillations. We study the phase diagram for several model parametrizations. The features of each phase are analyzed through the behavior of the chiral and superconducting condensates together with the different particle densities for increasing chemical potential or magnetic field. While confirming previous results derived for the zero magnetic field or isospin symmetric matter case, we show how the phases are modified in the presence of β -equilibrium as well as color and electric charge neutrality conditions.

  1. EMC and polarized EMC effects in Nuclei

    SciTech Connect

    Ian Cloet; Wolfgang Bentz; Anthony Thomas

    2006-05-23

    We determine nuclear structure functions and quark distributions for {sup 7}Li, {sup 11}B, {sup 15}N and {sup 27}Al. For the nucleon bound state we solve the covariant quark-diquark equations in a confining Nambu--Jona-Lasinio model, which yields excellent results for the free nucleon structure functions. The nucleus is described using a relativistic shell model, including mean scalar and vector fields that couple to the quarks in the nucleon. The nuclear structure functions are then obtained as a convolution of the structure function of the bound nucleon with the light-cone nucleon distributions. We find that we are readily able to reproduce the EMC effect in finite nuclei and confirm earlier nuclear matter studies that found a large polarized EMC effect.

  2. Light-by-Light Hadronic Corrections to the Muon G-2 Problem Within the Nonlocal Chiral Quark Model

    NASA Astrophysics Data System (ADS)

    Dorokhov, A. E.; Radzhabov, A. E.; Zhevlakov, A. S.

    2017-03-01

    Results of calculation of the light-by-light contribution from the lightest neutral pseudoscalar and scalar mesons and the dynamical quark loop to the muon anomalous magnetic moment are discussed in the framework of the nonlocal SU(3) × SU(3) chiral quark model. The model is based on four-quark interaction of the Nambu-Jona-Lasinio type and Kobayashi-Maskawa-`t Hooft six-quark interaction. The full kinematic dependence of vertices with off-shell mesons and photons in intermediate states in the light-by-light scattering amplitude is taken into account. All calculations are elaborated in explicitly gauge-invariant manner. These results complete calculations of all hadronic light-by-light scattering contributions to aμ in the leading order in the 1/Nc expansion. The final result does not allow the discrepancy between the experiment and the Standard Model to be explained.

  3. Spin polarization in high density quark matter under a strong external magnetic field

    NASA Astrophysics Data System (ADS)

    Tsue, Yasuhiko; da Providência, João; Providência, Constança; Yamamura, Masatoshi; Bohr, Henrik

    In high density quark matter under a strong external magnetic field, possible phases are investigated by using the two-flavor Nambu-Jona-Lasinio (NJL) model with tensor-type four-point interaction between quarks, as well as the axial-vector-type four-point interaction. In the tensor-type interaction under the strong external magnetic field, it is shown that a quark spin polarized phase is realized in all regions of the quark chemical potential under consideration within the lowest Landau level approximation. In the axial-vector-type interaction, it is also shown that the quark spin polarized phase appears in the wide range of the quark chemical potential. In both the interactions, the quark mass in zero and small chemical potential regions increases which indicates that the chiral symmetry breaking is enhanced, namely the magnetic catalysis occurs.

  4. Equation of State of the Strong Interaction Matter in an External Magnetic Field

    NASA Astrophysics Data System (ADS)

    Zhang, Rui; Liu, Yu-Xin

    2015-10-01

    We investigate the equation of state of the strong interaction matter in a background magnetic field via the two flavor Nambu-Jona-Lasinio model. Starting from the mean-field thermodynamical potential density Ω, we calculate the pressure density p, the entropy density s, the energy density ɛ, and the interaction measure (ɛ - 3p)/T4 of the strong interaction matter at finite temperature and finite magnetic field. The results manifest that the chiral phase transition is just a crossover but not a low order phase transition. Moreover there may exist magnetic catalysis effect, and its mechanism is just the effective dimension reduction induced by the magnetic field. Supported by the National Natural Science Foundation of China under Grant Nos. 10935001, 11175004 and 11435001, and the National Key Basic Research Program of China under Grant Nos. G2013CB834400 and 2015CB856900

  5. QCD phase diagram with a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Lu, Ya; Cui, Zhu-Fang; Pan, Zan; Chang, Chao-Hsi; Zong, Hong-Shi

    2016-04-01

    The effect of chirality imbalance on the QCD phase diagram is studied within the two flavors Nambu-Jona-Lasinio model. We focus especially on the issues related to how the chiral chemical potential (μ5 ) affects the phase diagram, and find the "chiral catalysis" as well as "inverse chiral catalysis" effects, which are analogous to the magnetic catalysis and inverse magnetic catalysis effects. Furthermore, our results are different from the existing chiral model calculations, namely, there is no CEP5 on the T -μ5 plane, since the whole phase transition is a crossover. In addition, with the introduction of the chiral chemical potential, various QCD susceptibilities and the corresponding critical exponents are also studied.

  6. Nonperturbative partonic quasidistributions of the pion from chiral quark models

    NASA Astrophysics Data System (ADS)

    Broniowski, Wojciech; Ruiz Arriola, Enrique

    2017-10-01

    We evaluate nonperturbatively the quark quasidistribution amplitude and the valence quark quasidistribution function of the pion in the framework of chiral quark models, namely the Nambu-Jona-Lasinio model and the Spectral Quark Model. We arrive at simple analytic expressions, where the nonperturbative dependence on the longitudinal momentum of the pion can be explicitly assessed. The model results for the quark quasidistribution amplitude of the pion compare favorably to the data obtained from the Euclidean lattice simulations. The quark distribution amplitude, arising in the limit of infinite longitudinal momentum of the pion, agrees, after suitable QCD evolution, to the recent data extracted from Euclidean lattices, as well as to the old data from transverse lattice simulations.

  7. Spinodal instabilities in baryon-rich quark matter

    NASA Astrophysics Data System (ADS)

    Ko, Che Ming; Li, Feng

    For quark matter at finite baryon chemical potential, its density develops large fluctuations when it undergoes a first-order phase transition. Based on the Nambu-Jona-Lasinio (NJL) model, we have used the linear response theory to study the growth rate of density fluctuations and its dependence on the wavelength of unstable modes. Using the transport equation derived from the NJL model, we have also studied the time evolution of the unstable modes and the density fluctuations in a baryon-rich quark matter that is confined in a finite volume. Allowing the expansion of the quark matter, we have further studied the survivability of the density fluctuations as the density and temperature of the quark matter decrease. Possible experimental signatures of the density fluctuations have been suggested.

  8. Decision-making styles: managerial application of the MBTI and type theory.

    PubMed

    Freund, C M

    1988-12-01

    Applying type theory is a relatively inexpensive way for managers to increase effectiveness by emphasizing the qualitative issues in organizations. The author describes managerial and organizational uses of C.G. Jung's theory of psychological type, as operationalized in the Myers-Briggs Type Indicator (MBTI). The MBTI is useful not only in identifying individual preferences, but also in developing effective managerial and working terms. Knowledge of one's own type and the type of others can help managers motivate others, maximize human resources, persuade others, and gain cooperation. An article in the January 1989 issue of JONA discusses the author's use of the MBTI to assess decision-making styles and the compatibility of hospital chief nursing officers and executive officers.

  9. {eta}'(958)-mesic nuclei formation and UA(1) anomaly at finite density

    SciTech Connect

    Nagahiro, Hideko; Takizawa, Makoto; Hirenzaki, Satoru

    2006-07-11

    We discuss the possibility of producing the bound states of the {eta}'(958) meson in nuclei theoretically using the the Nambu-Jona-Lasinio (NJL) model. We calculate the formation cross section of the {eta}' bound states with the Green function method for the ({gamma},p) reaction and discuss the experimental feasibility at photon facilities such as SPring-8. We conclude that we can expect to observe resonance peaks in ({gamma},p) spectra for the formation of {eta}' bound states and we can deduce new information on {eta}' properties at finite density. These observations are believed to be essential to know the possible mass shift of {eta}' and deduce new information on the effective restoration of the chiral UA(1) anomaly at finite density.

  10. Fate of pion condensation in quark matter: From the chiral limit to the physical pion mass

    SciTech Connect

    Abuki, H.; Anglani, R.; Pellicoro, M.; Ruggieri, M.; Gatto, R.

    2009-02-01

    We study aspects of the pion condensation in two-flavor neutral quark matter using the Nambu-Jona-Lasinio model of QCD at finite density. We investigate the role of electric charge neutrality, and explicit symmetry breaking via quark mass, both of which control the onset of the charged pion ({pi}{sup c}) condensation. We show that the equality between the electric chemical potential and the in-medium pion mass, {mu}{sub e}=M{sub {pi}{sup -}}, as a threshold, persists even for a composite pion system in the medium, provided the transition to the pion condensed phase is of the second order. Moreover, we find that the pion condensate in neutral quark matter is extremely fragile with respect to the symmetry breaking effect via a current quark mass m, and is ruled out for m larger than the order of 10 keV.

  11. Restoration of UA(1) symmetry and meson spectrum in hot or dense matter

    NASA Astrophysics Data System (ADS)

    Costa, P.; Ruivo, M. C.; de Sousa, C. A.; Kalinovsky, Yu. L.

    2005-06-01

    We explore the effects of breaking and restoration of chiral and axial symmetries using an extended three-flavor Nambu-Jona-Lasinio model that incorporates explicitly the axial anomaly through the 't Hooft interaction. We implement a temperature (density) dependence of the anomaly coefficient motivated by lattice results for the topological susceptibility. The spectrum of scalar and pseudoscalar mesons is analyzed bearing in mind the identification of chiral partners and the study of its convergence. We also concentrate on the behavior of the mixing angles that give us relevant information on the issue under discussion. The results suggest that the axial part of the symmetry is restored before the possible restoration of the full U(3)⊗U(3) chiral symmetry might occur.

  12. Quark mass functions and pion structure in Minkowski space

    SciTech Connect

    Biernat, Elmer P.; Gross, Franz L.; Pena, Maria Teresa; Stadler, Alfred

    2014-03-01

    We present a study of the dressed quark mass function and the pion structure in Minkowski space using the Covariant Spectator Theory (CST). The quark propagators are dressed with the same kernel that describes the interaction between different quarks. We use an interaction kernel in momentum space that is a relativistic generalization of the linear confining q-qbar potential and a constant potential shift that defines the energy scale. The confining interaction has a Lorentz scalar part that is not chirally invariant by itself but decouples from the equations in the chiral limit and therefore allows the Nambu--Jona-Lasinio (NJL) mechanism to work. We adjust the parameters of our quark mass function calculated in Minkowski-space to agree with LQCD data obtained in Euclidean space. Results of a calculation of the pion electromagnetic form factor in the relativistic impulse approximation using the same mass function are presented and compared with experimental data.

  13. Critical end point in a thermomagnetic nonlocal NJL model

    NASA Astrophysics Data System (ADS)

    Márquez, F.; Zamora, R.

    2017-09-01

    In this paper, we explore the critical end point in the T ‑ μ phase diagram of a thermomagnetic nonlocal Nambu-Jona-Lasinio model in the weak field limit. We work with the Gaussian regulator, and find that a crossover takes place at μ, B = 0. The crossover turns to a first-order phase transition as the chemical potential or the magnetic field increases. The critical end point of the phase diagram occurs at a higher temperature and lower chemical potential as the magnetic field increases. This result is in accordance to similar findings in other effective models. We also find that there is a critical magnetic field, for which a first-order phase transition takes place even at μ = 0.

  14. The impact of cognitive strategy instruction on deaf learners: an international comparative study.

    PubMed

    Martin, D S; Craft, A; Sheng, Z N

    2001-10-01

    Teacher cohorts in England and China received special training in techniques for teaching higher-level critical and creative cognitive strategies to deaf learners. Both cohorts implemented the strategies in the classroom at least twice weekly for 6 months. Measures included Raven's Standard Progressive Matrices (1959), a systematic observation checklist for cognitive behaviors (Martin & Craft, 1998), and critical and creative problem situations to which students had to respond. Results were compared with those from a study of similar learners in the United States (Martin & Jonas, 1985), and little difference was found. Students in all three countries improved in reasoning, devising real-world problem solutions involving critical thinking (but not creative thinking), using cognitive vocabulary in the classroom, and expressing others' viewpoints. Postintervention focus groups showed teachers in China used a more invariant sequence in teaching the cognitive strategies, but teachers in all three countries experienced similar expansion in cognitive terminology and self-perceptions as teachers of problem solving.

  15. The NJL Model for Quark Fragmentation Functions

    SciTech Connect

    T. Ito, W. Bentz, I. Cloet, A W Thomas, K. Yazaki

    2009-10-01

    A description of fragmentation functions which satisfy the momentum and isospin sum rules is presented in an effective quark theory. Concentrating on the pion fragmentation function, we first explain the reason why the elementary (lowest order) fragmentation process q → qπ is completely inadequate to describe the empirical data, although the “crossed” process π → qq describes the quark distribution functions in the pion reasonably well. Then, taking into account cascade-like processes in a modified jet-model approach, we show that the momentum and isospin sum rules can be satisfied naturally without introducing any ad-hoc parameters. We present numerical results for the Nambu-Jona-Lasinio model in the invariant mass regularization scheme, and compare the results with the empirical parametrizations. We argue that this NJL-jet model provides a very useful framework to calculate the fragmentation functions in an effective chiral quark theory.

  16. QCD relics in the present-day Universe?

    NASA Astrophysics Data System (ADS)

    Ribeiro, J. E. F. T.; Antonov, D.; Nefediev, A. V.

    2011-05-01

    A possibility is suggested for the formation in the Universe of domains occupied by coherent-like states of strongly correlated quark-antiquark pairs. Only domains of the radius larger than 5 fm had a chance to survive over the entire history of the Universe, while the requirement of stability against the gravitational collapse restricts the maximum domain's radius to 14 km. Within the Generalised Nambu-Jona-Lasinio model, an exponential suppression with the domain's volume is found for the overlap between the macroscopic ground-state wavefunction of the quark-antiquark pairs and the QCD vacuum. This finding supports, at the microscopic level, the above arguments in favour of the stability of the domains.

  17. Current status of poliovirus infections.

    PubMed

    Melnick, J L

    1996-07-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus.

  18. Salk's HIV immunogen: an immune-based therapy in human trials since 1988.

    PubMed

    Jonas Salk, the developer of the first polio vaccine, has created a therapeutic vaccine for HIV which helps the immune system fight disease progression. Salk uses inactivated HIV-1 virus combined with Incomplete Freund's Adjuvant (IFA) in the vaccine preparation. The resulting HIV-1 immunogen was first studied in 1987, and since then, 235 seropositive individuals have received inoculations without serious adverse effects. Data from the first 25 subjects indicate that immunization with the HIV-1 immunogen results in improvement of cell-mediated response against the virus, a slower increase in the amount of virus present, and a reduced rate of clinical progression. Subsequent studies also show that higher doses of immunogen may produce stronger cell-mediated responses and high HIV-DTH (delayed-type hypersensitivity responsiveness immunogen) is associated with better outcome. Additional trials of HIV-1 immunogen are awaiting Food and Drug Administration approval.

  19. Remune trial will stop; new trials planned.

    PubMed

    James, J S

    1999-05-21

    A clinical trial using remune, the anti-HIV vaccine developed by the late Dr. Jonas Salk, has been ended. The study is a clinical-endpoint trial which looks for statistically significant differences in AIDS sickness or death between patients who add remune to their treatment regimens versus those who use a placebo. Agouron Pharmaceuticals and the Immune Response Corporation who were conducting the trial announced their decision to stop it after an analysis by the Data Safety Monitoring Board. No differences in clinical endpoints were found and it was projected that continuing the trial would likely not find any. The companies are now planning two new Phase III trials using viral load testing rather than clinical endpoints as study criteria.

  20. Studies of the hybrid star structure within 2 +1 flavors NJL model

    NASA Astrophysics Data System (ADS)

    Li, Cheng-Ming; Zhang, Jin-Li; Zhao, Tong; Zhao, Ya-Peng; Zong, Hong-Shi

    2017-03-01

    In this paper, we use the equation of state (EOS) of the 2 +1 flavors Nambu-Jona-Lasinio (NJL) model to study the structure of compact stars. To avoid the ultraviolet divergence, we employ the proper-time regularization (PTR) with an ultraviolet cutoff. For comparison, we fix three sets of parameters, where the constraints of chemical equilibrium and electric charge neutrality conditions are taken into consideration. With a certain interpolation method in the crossover region, we construct three corresponding hybrid EOSs but find that the maximum masses of hybrid stars in the three different cases do not differ too much. It should be pointed out that the results we get are in accordance with the recent astro-observation PSR J 0348 +0432 , PSR J 1614 -2230 , PSR J 1946 +3417 .

  1. Ab initio calculation of a global potential, vibrational energies, and wave functions for HCN/HNC, and a simulation of the (A-tilde)-(X-tilde) emission spectrum

    NASA Technical Reports Server (NTRS)

    Bowman, Joel M.; Gazdy, Bela; Bentley, Joseph A.; Lee, Timothy J.; Dateo, Christopher E.

    1993-01-01

    A potential energy surface for the HCN/HNC system which is a fit to extensive, high-quality ab initio, coupled-cluster calculations is presented. All HCN and HNC states with energies below the energy of the first delocalized state are reported and characterized. Vibrational transition energies are compared with all available experimental data on HCN and HNC, including high CH-overtone states up to 23,063/cm. A simulation of the (A-tilde)-(X-tilde) stimulated emission pumping (SEP) spectrum is also reported, and the results are compared to experiment. Franck-Condon factors are reported for odd bending states of HCN, with one quantum of vibrational angular momentum, in order to compare with the recent assignment by Jonas et al. (1992), on the basis of axis-switching arguments of a number of previously unassigned states in the SEP spectrum.

  2. Critical behaviors near the (tri-)critical end point of QCD within the NJL model

    NASA Astrophysics Data System (ADS)

    Lu, Ya; Du, Yi-Lun; Cui, Zhu-Fang; Zong, Hong-Shi

    2015-10-01

    We investigate the dynamical chiral symmetry breaking and its restoration at finite density and temperature within the two-flavor Nambu-Jona-Lasinio model, and mainly focus on the critical behaviors near the critical end point (CEP) and tricritical point (TCP) of quantum chromodynamics. The multi-solution region of the Nambu and Wigner ones is determined in the phase diagram for the massive and massless current quark, respectively. We use the various susceptibilities to locate the CEP/TCP and then extract the critical exponents near them. Our calculations reveal that the various susceptibilities share the same critical behaviors for the physical current quark mass, while they show different features in the chiral limit.

  3. Isospin dependence of EMC effect explains NuTeV anomaly

    SciTech Connect

    Cloet, Ian; Bentz, Wolfgang; Thomas, Anthony

    2009-01-01

    A neutron or proton excess in nuclei leads to an isovector-vector mean-field which, through its coupling to the quarks in a bound nucleon, implies a shift in the quark distributions with respect to the Bjorken scaling variable. We show that this result leads to an additional correction to the NuTeV measurement of sin^2Theta_W. The sign of this correction is largely model independent and acts to reduce the NuTeV result. Explicit calculation within a covariant and confining Nambu Jona-Lasinio model predicts that this vector field correction accounts for approximately two-thirds of the NuTeV anomaly. We are therefore led to offer a new interpretation of the NuTeV measurement, namely, that it is further evidence for the medium modification of the bound nucleon wavefunction.

  4. QCD Phase Diagram at Finite Baryon and Isospin Chemical Potentials

    SciTech Connect

    Sasaki, T.; Sakai, Y.; Yahiro, M.; Kouno, H.

    2011-10-21

    The phase structure of two-flavor QCD is explored for finite temperature T and finite baryon- and isospin-chemical potentials, {mu}{sub B} and {mu}{sub I}, by using the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. The PNJL model with the scalar-type eight-quark interaction can reproduce lattice QCD data in the {mu}{sub I}-T plane at {mu}{sub B} = 0. In the {mu}{sub I}-{mu}{sub B}-T space, the critical endpoint of the chiral phase transition in the {mu}{sub B}-T plane at {mu}{sub I} = 0 moves to the tricritical point of the pion-superfluidity phase transition in the {mu}{sub I}-T plane at {mu}{sub B} = 0 as {mu}{sub I} increases.

  5. Validity of anomalous diffraction approximation in m- χ domain

    NASA Astrophysics Data System (ADS)

    Liu, Chun-Lei

    In a recent paper, Liu et al. [Liu, C., Jonas, P.R., Saunders, C.P.R., 1996. Accuracy of the anomalous diffraction approximation to the light scattering by column-like ice crystals. Atmos. Res. 41, 63-69] reported that the anomalous diffraction approximation (ADA) accuracy is not sensitive to van de Hulst's condition | m-1|≪1, but is dependent on the size parameter χ. Videen and Chýlek [Videen, G., Chýlek, P., 1998. Anomalous diffraction approximation limits. Atmos. Res., this issue] pointed out that this result is at odds with previous research, and their results indicated that the accuracy of ADA is much dependent on the condition of | m-1|≪1. Some calculated results are presented here to provide further discussion of the ADA validity in the calculation of particle extinction and absorption efficiencies.

  6. Chiral relaxation time at the crossover of quantum chromodynamics

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.; Chernodub, M.

    2016-09-01

    We study microscopic processes responsible for chirality flips in the thermal bath of quantum chromodynamics at finite temperature and zero baryon chemical potential. We focus on the temperature range where the crossover from chirally broken phase to quark-gluon plasma takes place, namely, T ≃(150 ,200 ) MeV . The processes we consider are quark-quark scatterings mediated by collective excitations with the quantum number of pions and σ meson; hence we refer to these processes simply as one-pion (one-σ ) exchanges. We use a Nambu-Jona-Lasinio model to compute equilibrium properties of the thermal bath, as well as the relevant scattering kernel to be used in the collision integral to estimate the chiral relaxation time τ . We find τ ≃0.1 ÷1 fm /c around the chiral crossover.

  7. A holographic study of the gauged NJL model

    NASA Astrophysics Data System (ADS)

    Clemens, Will; Evans, Nick

    2017-08-01

    The Nambu Jona-Lasinio model of chiral symmetry breaking predicts a second order chiral phase transition. If the fermions in addition have non-abelian gauge interactions then the transition is expected to become a crossover as the NJL term enhances the IR chiral symmetry breaking of the gauge theory. We study this behaviour in the holographic Dynamic AdS/QCD description of a non-abelian gauge theory with the NJL interaction included using Witten's multi-trace prescription. We study the behaviour of the mesonic spectrum as a function of the NJL coupling and the ratio of the UV cut off scale to the dynamical scale of the gauge theory.

  8. Low-energy phenomenology of scalarless standard-model extensions with high-energy Lorentz violation

    SciTech Connect

    Anselmi, Damiano; Ciuffoli, Emilio

    2011-03-01

    We consider renormalizable standard model extensions that violate Lorentz symmetry at high energies, but preserve CPT, and do not contain elementary scalar fields. A Nambu-Jona-Lasinio mechanism gives masses to fermions and gauge bosons and generates composite Higgs fields at low energies. We study the effective potential at the leading order of the large-N{sub c} expansion, prove that there exists a broken phase, and study the phase space. In general, the minimum may break invariance under boosts, rotations, and CPT, but we give evidence that there exists a Lorentz invariant phase. We study the spectrum of composite bosons and the low-energy theory in the Lorentz phase. Our approach predicts relations among the parameters of the low-energy theory. We find that such relations are compatible with the experimental data within theoretical errors. We also study the mixing among generations, the emergence of the CKM matrix, and neutrino oscillations.

  9. C P violation and chiral symmetry breaking in hot and dense quark matter in the presence of a magnetic field

    NASA Astrophysics Data System (ADS)

    Chatterjee, Bhaswar; Mishra, Hiranmaya; Mishra, Amruta

    2015-02-01

    We investigate chiral symmetry breaking and strong charge parity (C P ) violation effects on the phase diagram of strongly interacting matter in the presence of a constant magnetic field. The effects of a magnetic field and strong C P violating term on the phase structure at finite temperature and density are studied within a three flavor Nambu-Jona-Lasinio model including the Kobayashi-Maskawa-t'Hooft determinant term. This is investigated using an explicit variational ansatz for ground state with quark-antiquark pairs leading to condensates both in scalar and pseudoscalar channels. A magnetic field enhances the condensate in both the channels. Inverse magnetic catalysis for C P transition at finite chemical potential is seen for zero temperature and for small magnetic fields. The C P transition becomes first order at finite baryon chemical potential and could be relevant for generating C P -odd metastable domains in heavy ion collision experiments.

  10. Johann von Lamont: A Pioneer in Geomagnetism

    NASA Astrophysics Data System (ADS)

    Soffel, Heinrich

    2006-06-01

    The 200th birthday of John Lamont (1805-1879, Figure 1), a pioneer in the study of geomagnetism, was marked on 13 December 2005. Lamont founded the Munich Geomagnetic Observatory in 1840 and was a member of the group of scientists including Carl Friedrich Gauss, Alexander von Humboldt, Eduard Sabine, Jonas Angstrøm, Humphret Lloyd, Adolf Kupffer, Karl Kreil, and Adolphe Quetelet who composed the Göttingen Magnetic Union. They organized an international network of geomagnetic observatories [Barraclough et al., 1992]. The present knowledge of the geomagnetic field and its secular variation is largely based on the data collected by the global network of geomagnetic observatories during the last 170 years. Lamont's talents and his dedication and enthusiasm for discovery are reflected in the depth and scope of his contributions to a broad variety of natural sciences such as astronomy, meteorology, geomagnetism, and geodesy. However, this article just touches on his merits in geomagnetism.

  11. Diquarks in the color-flavor locked phase of dense quark matter

    SciTech Connect

    Ebert, D.; Klimenko, K. G.

    2007-02-15

    Diquark excitations of dense quark matter are considered in the framework of the Nambu-Jona-Lasinio model with three types of massless quarks in the presence of a quark number chemical potential {mu}. We investigate the effective action of meson and diquark fields at sufficiently high values of {mu}, where the color-flavor locked (CFL) phase is realized, and prove the existence of NG bosons in the sector of pseudoscalar diquarks. In the sector of scalar diquarks an additional NG boson is found, corresponding to the spontaneous breaking of the U(1){sub B} baryon symmetry in the CFL phase. Finally, the existence of massive scalar and pseudoscalar diquark excitations is demonstrated.

  12. Emerging medical technologies and emerging conceptions of health.

    PubMed

    Stempsey, William E

    2006-01-01

    Using ideas gleaned from the philosophy of technology of Martin Heidegger and Hans Jonas and the philosophy of health of Georges Canguilhem, I argue that one of the characteristics of emerging medical technologies is that these technologies lead to new conceptions of health. When technologies enable the body to respond to more and more challenges of disease, we thus establish new norms of health. Given the continued development of successful technologies, we come to expect more and more that our bodies should be able to respond to ever-new challenges of environment and disease by establishing ever-new norms of health. Technologies may aim at the prevention and treatment of disease, but they also bring about modifications of what we consider normal for the human being. Thus, new norms of health arise from technological innovation.

  13. π0 pole mass calculation in a strong magnetic field and lattice constraints

    NASA Astrophysics Data System (ADS)

    Avancini, Sidney S.; Farias, Ricardo L. S.; Benghi Pinto, Marcus; Tavares, William R.; Timóteo, Varese S.

    2017-04-01

    The π0 neutral meson pole mass is calculated in a strongly magnetized medium using the SU(2) Nambu-Jona-Lasinio model within the random phase approximation (RPA) at zero temperature and zero baryonic density. We employ a magnetic field dependent coupling, G (eB), fitted to reproduce lattice QCD results for the quark condensates. Divergent quantities are handled with a magnetic field independent regularization scheme in order to avoid unphysical oscillations. A comparison between the running and the fixed couplings reveals that the former produces results much closer to the predictions from recent lattice calculations. In particular, we find that the π0 meson mass systematically decreases when the magnetic field increases while the scalar mass remains almost constant. We also investigate how the magnetic background influences other mesonic properties such as fπ0 and gπ0qq.

  14. Modern compact star observations and the quark matter equation of state

    NASA Astrophysics Data System (ADS)

    Klähn, T.; Blaschke, D.; Sandin, F.; Fuchs, Ch.; Faessler, A.; Grigorian, H.; Röpke, G.; Trümper, J.

    2007-10-01

    We present a hybrid equation of state (EoS) for dense matter that satisfies phenomenological constraints from modern compact star (CS) observations which indicate high maximum masses (M ∼ 2M⊙) and large radii (R > 12 km). The corresponding isospin symmetric EoS is consistent with flow data analyses of heavy-ion collisions and a deconfinement transition at ∼ 0.55 fm-3. The quark matter phase is described by a 3-flavor Nambu-Jona-Lasinio model that accounts for scalar diquark condensation and vector meson interactions while the nuclear matter phase is obtained within the Dirac-Brueckner-Hartree-Fock (DBHF) approach using the Bonn-A potential. We demonstrate that both pure neutron stars and neutron stars with quark matter cores are consistent with modern CS observations. Hybrid star configurations with a CFL quark core are unstable within the present model.

  15. Polyakov-loop suppression of colored states in a quark-meson-diquark plasma

    NASA Astrophysics Data System (ADS)

    Blaschke, D.; Dubinin, A.; Buballa, M.

    2015-06-01

    A quark-meson-diquark plasma is considered within the Polyakov-loop extended Nambu-Jona-Lasinio model for dynamical chiral symmetry breaking and restoration in quark matter. Based on a generalized Beth-Uhlenbeck approach to mesons and diquarks we present the thermodynamics of this system including the Mott dissociation of mesons and diquarks at finite temperature. A striking result is the suppression of the diquark abundance below the chiral restoration temperature by the coupling to the Polyakov loop, because of their color degree of freedom. This is understood in close analogy to the suppression of quark distributions by the same mechanism. Mesons as color singlets are unaffected by the Polyakov-loop suppression. At temperatures above the chiral restoration mesons and diquarks are both suppressed due to the Mott effect, whereby the positive resonance contribution to the pressure is largely compensated by the negative scattering contribution in accordance with the Levinson theorem.

  16. G. Stanley Hall and The Journal of Genetic Psychology: A Note.

    PubMed

    Hogan, John D

    2016-01-01

    The Journal of Genetic Psychology (originally called The Pedagogical Seminary) has a complicated history. Known primarily as a journal of development psychology, it was originally intended to be a journal of higher education. In addition, G. Stanley Hall created it, at least in part, to curry favor with Jonas Clark, the benefactor of Clark University. The journal had a cumbersome start, with irregular issues for most of its first decade. Hall was a hands-on editor, often contributing articles and reviews as well as the texts of many of his speeches. A substantial number of additional articles were written by Clark University faculty and fellows where Hall was president. After Hall.s death, the editor became Carl Murchison who eventually left Clark University with the journal and continued to publish it privately until his death. Through the years, the journal has been the source for many classic articles in developmental psychology.

  17. Current status of poliovirus infections.

    PubMed Central

    Melnick, J L

    1996-01-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus. PMID:8809461

  18. Neutrino emissivities and bulk viscosity in neutral two-flavor quark matter

    NASA Astrophysics Data System (ADS)

    Berdermann, J.; Blaschke, D.; Fischer, T.; Kachanovich, A.

    2016-12-01

    We study thermodynamic and transport properties for the isotropic color-spin-locking (iso-CSL) phase of two-flavor superconducting quark matter under compact star constraints within a Nambu-Jona-Lasinio-type chiral quark model. Chiral symmetry breaking and the phase transition to superconducting quark matter leads to a density dependent change of quark masses, chemical potentials, and diquark gap. A self-consistent treatment of these physical quantities influences the microscopic calculations of transport properties. We present results for the iso-CSL direct URCA emissivities and bulk viscosities, which fulfil the constraints on quark matter derived from cooling and rotational evolution of compact stars. We compare our results with the phenomenologically successful, but yet heuristic 2 SC +X phase. We show that the microscopically founded iso-CSL phase can replace the purely phenomenological 2 SC +X phase in modern simulations of the cooling evolution for compact stars with color-superconducting quark matter interior.

  19. Ab initio calculation of a global potential, vibrational energies, and wave functions for HCN/HNC, and a simulation of the (A-tilde)-(X-tilde) emission spectrum

    NASA Technical Reports Server (NTRS)

    Bowman, Joel M.; Gazdy, Bela; Bentley, Joseph A.; Lee, Timothy J.; Dateo, Christopher E.

    1993-01-01

    A potential energy surface for the HCN/HNC system which is a fit to extensive, high-quality ab initio, coupled-cluster calculations is presented. All HCN and HNC states with energies below the energy of the first delocalized state are reported and characterized. Vibrational transition energies are compared with all available experimental data on HCN and HNC, including high CH-overtone states up to 23,063/cm. A simulation of the (A-tilde)-(X-tilde) stimulated emission pumping (SEP) spectrum is also reported, and the results are compared to experiment. Franck-Condon factors are reported for odd bending states of HCN, with one quantum of vibrational angular momentum, in order to compare with the recent assignment by Jonas et al. (1992), on the basis of axis-switching arguments of a number of previously unassigned states in the SEP spectrum.

  20. Symmetries in Physics

    NASA Astrophysics Data System (ADS)

    Brading, Katherine; Castellani, Elena

    2010-01-01

    Preface; Copyright acknowledgements; List of contributors; 1. Introduction; Part I. Continuous Symmetries: 2. Classic texts: extracts from Weyl and Wigner; 3. Review paper: On the significance of continuous symmetry to the foundations of physics C. Martin; 4. The philosophical roots of the gauge principle: Weyl and transcendental phenomenological idealism T. Ryckman; 5. Symmetries and Noether's theorems K. A. Brading and H. R. Brown; 6. General covariance, gauge theories, and the Kretschmann objection J. Norton; 7. The interpretation of gauge symmetry M. Redhead; 8. Tracking down gauge: an ode to the constrained Hamiltonian formalism J. Earman; 9. Time-dependent symmetries: the link between gauge symmetries and indeterminism D. Wallace; 10. A fourth way to the Aharanov-Bohm effect A. Nounou; Part II. Discrete Symmetries: 11. Classic texts: extracts from Lebniz, Kant and Black; 12. Review paper: Understanding permutation symmetry S. French and D. Rickles; 13. Quarticles and the identity of discernibles N. Hugget; 14. Review paper: Handedness, parity violation, and the reality of space O. Pooley; 15. Mirror symmetry: what is it for a relational space to be orientable? N. Huggett; 16. Physics and Leibniz's principles S. Saunders; Part III. Symmetry Breaking: 17: Classic texts: extracts from Curie and Weyl; 18. Extract from G. Jona-Lasinio: Cross-fertilization in theoretical physics: the case of condensed matter and particle physics G. Jona-Lasinio; 19. Review paper: On the meaning of symmetry breaking E. Castellani; 20. Rough guide to spontaneous symmetry breaking J. Earman; 21. Spontaneous symmetry breaking: theoretical arguments and philosophical problems M. Morrison; Part IV. General Interpretative Issues: 22. Classic texts: extracts from Wigner; 23. Symmetry as a guide to superfluous theoretical structure J. Ismael and B. van Fraassen; 24. Notes on symmetries G. Belot; 25. Symmetry, objectivity, and design P. Kosso; 26. Symmetry and equivalence E. Castellani.

  1. The responsible subject in the global age.

    PubMed

    Pulcini, Elena

    2010-09-01

    The first thesis of this article is that the concept of responsibility takes on an unprecedented meaning in the twentieth century resulting from the emergence of a new dimension of the other: to be responsible comes to mean not just to account for oneself in relation to the other, but also to take the other into account, to take care of the other-what I call responsibility towards (the other). The main reason for this change consists in the emergence of global risks and the necessity, as underlined by Hans Jonas, to be responsible for the destiny of the world and future generations. The problem, as explored in the article's second thesis, is that this implies the existence of a subject who is capable of responsibility. Jonas's insights on this point are insufficient, since he only recognizes duty as the fundament for his ethics of responsibility and thus neglects the problem of motivation. This is a particularly crucial problem today as we are witnessing the presence of a pathological subject, characterized by a split in his faculties (between doing and imagining, knowing and feeling). To underline this fact, this article makes use of Günther Anders's reflections, which provide a psycho-anthropological analysis of the subject, showing his pathologies and the necessity, from a moral perspective, to overcome his scission. Finally, this author suggests, as the article's third thesis, that this overcoming is the necessary fundament for the perception of risk, which in turn reinstates the subject's perception of his own vulnerability. Responsibility thus finds a motivation, which is neither altruistic nor duty-centred, in the awareness of our own vulnerability and the bond with the destiny of humankind as a whole.

  2. Symmetries in Physics

    NASA Astrophysics Data System (ADS)

    Brading, Katherine; Castellani, Elena

    2003-12-01

    Preface; Copyright acknowledgements; List of contributors; 1. Introduction; Part I. Continuous Symmetries: 2. Classic texts: extracts from Weyl and Wigner; 3. Review paper: On the significance of continuous symmetry to the foundations of physics C. Martin; 4. The philosophical roots of the gauge principle: Weyl and transcendental phenomenological idealism T. Ryckman; 5. Symmetries and Noether's theorems K. A. Brading and H. R. Brown; 6. General covariance, gauge theories, and the Kretschmann objection J. Norton; 7. The interpretation of gauge symmetry M. Redhead; 8. Tracking down gauge: an ode to the constrained Hamiltonian formalism J. Earman; 9. Time-dependent symmetries: the link between gauge symmetries and indeterminism D. Wallace; 10. A fourth way to the Aharanov-Bohm effect A. Nounou; Part II. Discrete Symmetries: 11. Classic texts: extracts from Lebniz, Kant and Black; 12. Review paper: Understanding permutation symmetry S. French and D. Rickles; 13. Quarticles and the identity of discernibles N. Hugget; 14. Review paper: Handedness, parity violation, and the reality of space O. Pooley; 15. Mirror symmetry: what is it for a relational space to be orientable? N. Huggett; 16. Physics and Leibniz's principles S. Saunders; Part III. Symmetry Breaking: 17: Classic texts: extracts from Curie and Weyl; 18. Extract from G. Jona-Lasinio: Cross-fertilization in theoretical physics: the case of condensed matter and particle physics G. Jona-Lasinio; 19. Review paper: On the meaning of symmetry breaking E. Castellani; 20. Rough guide to spontaneous symmetry breaking J. Earman; 21. Spontaneous symmetry breaking: theoretical arguments and philosophical problems M. Morrison; Part IV. General Interpretative Issues: 22. Classic texts: extracts from Wigner; 23. Symmetry as a guide to superfluous theoretical structure J. Ismael and B. van Fraassen; 24. Notes on symmetries G. Belot; 25. Symmetry, objectivity, and design P. Kosso; 26. Symmetry and equivalence E. Castellani.

  3. Musculo-nasomucosal unit with complete lateral bony freeing and medial rotation for ideal C-shape restoration and retropositioning of the levator veli palatini.

    PubMed

    El-Shazly, Mohamed

    2012-11-01

    No definitive procedure for cleft repair has been identified yet as the gold standard. Accordingly, this work tried to appraise the hypothesis that if the bony detachment and full retropositioning of the levator veli palatini muscle can ideally present an anatomical C-shape muscular sling restoration and if this is accompanied with pushback palatoplasty, would this present a better result in terms of tissue fistulation and phonetic impairment? A series of 74 different degrees of palatal clefts were operated by pushback palatoplasty combined with a modified approach of the levator vili palatini. This muscle was dissected only from the oral mucosa while kept attached to the nasal one as a musculo-nasomucosal unit. This unit was completely detached from the bony margin of the hard palate and then medially rotated and retropositioned in a typical C-shape mobile sling. Evaluations included suture line assessment and fistula development, and following the child's need for speech therapy. There were no intraoperative complications. Definite anterior fistulae with nasal air and foot leakage were observed in 2 cases. Four cases had postoperative velopharyngeal incompetence with a need for speech therapy. Tension-free closure, lower risk of fistula, good restoration of velopharyngeal functions, ability to be performed on all cleft types, ability to provide a good intraoperative exposure, and being a single stage seem to be the most important advantages of this unpublished technique.

  4. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography

    PubMed Central

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion. PMID:27253433

  5. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography.

    PubMed

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion.

  6. Transpulmonary pressure monitoring during mechanical ventilation: a bench-to-bedside review.

    PubMed

    Mietto, Cristina; Malbrain, Manu L N G; Chiumello, Davide

    2015-01-01

    Different ventilation strategies have been suggested in the past in patients with acute respiratory distress syndrome (ARDS). Airway pressure monitoring alone is inadequate to assure optimal ventilatory support in ARDS patients. The assessment of transpulmonary pressure (PTP) can help clinicians to tailor mechanical ventilation to the individual patient needs. Transpulmonary pressure monitoring, defined as airway pressure (Paw) minus intrathoracic pressure (ITP), provides essential information about chest wall mechanics and its effects on the respiratory system and lung mechanics. The positioning of an esophageal catheter is required to measure the esophageal pressure (Peso), which is clinically used as a surrogate for ITP or pleural pressure (Ppl), and calculates the transpulmonary pressure. The benefits of such a ventilation approach are avoiding excessive lung stress and individualizing the positive end-expiratory pressure (PEEP) setting. The aim is to prevent over-distention of alveoli and the cyclic recruitment/derecruitment or shear stress of lung parenchyma, mechanisms associated with ventilator-induced lung injury (VILI). Knowledge of the real lung distending pressure, i.e. the transpulmonary pressure, has shown to be useful in both controlled and assisted mechanical ventilation. In the latter ventilator modes, Peso measurement allows one to assess a patient's respiratory effort, patient-ventilator asynchrony, intrinsic PEEP and the calculation of work of breathing. Conditions that have an impact on Peso, such as abdominal hypertension, will also be discussed briefly.

  7. Twin pregnancy and partial hydatidiform mole following in vitro fertilization and embryos transfer: a novel case of placental mosaicism.

    PubMed

    Sun, Cheng-juan; Zhao, You-ping; Yu, Song; Fan, Ling; Wu, Qing-qing; Li, Guang-hui; Zhang, Wei-yuan

    2012-12-01

    Twin pregnancy with mosaic partial hydatidiform mole (PHM) and survival of two healthy fetuses following in vitro fertilization and embryos transfer (IVF-ET) is a rare situation and is considered a challenge for management. A 32-year-old Chinese woman conceived twin pregnancy following IVF-ET. At 22 weeks' gestation, an additional intrauterine echogenic mass with features of PHM were shown by successive ultrasound examinations. At 35 weeks' gestation, two live male infants and two placentas were delivered by caesarean section (CS). Histologic examination of the abnormal placenta confirmed mosaic PHM. Genetic study showed the abnormal placental mosaicism (expressed in molar-69XXY and normal vili-46XY), co-existing with a hypospadia new-born (46XY) in one amniotic sac. However, the other one was normal. Serial serum β-hCG levels showed a declining trend and serum β-human chorionic gonadotropin (hCG) were undetectable at 6 months after delivery. The case demonstrated that it is possible to prolonged gestation by PHM under close surveillance during the entire pregnancy.

  8. Optical coherence tomography and confocal fluorescence microscopy as a combined method for studying morphological changes in lung dynamics

    NASA Astrophysics Data System (ADS)

    Gaertner, Maria; Cimalla, Peter; Knels, Lilla; Meissner, Sven; Schnabel, Christian; Kuebler, Wolfgang M.; Koch, Edmund

    2011-03-01

    Acute lung injury (ALI) is a severe pulmonary disease leading to hypoxemia accompanied by a reduced compliance and partial edema of the lung. Most of the patients have to be ventilated to compensate for the lack of oxygen. The treatment is strongly connected with ventilator induced lung injury (VILI), which is believed to introduce further stress to the lung and changes in its elastic performance. A thorough understanding of the organs micro-structure is crucial to gain more insight into the course of the disease. Due to backscattering of near-infrared light, detailed description of lung morphology can be obtained using optical coherence tomography (OCT), a non-invasive, non-contact, high resolution and fast three-dimensional imaging technique. One of its drawbacks lies in the non-specificity of light distribution in relation to defined substances, like elastic biomolecules. Using fluorescence detection, these chemical components can be visualized by introducing specifically binding fluorophores. This study presents a combined setup for studying alveolar compliance depending on volume changes and elastic fiber distributions. Simultaneously acquired OCT and confocal fluorescence images allow an entire view into morphological rearrangements during ventilation for an ex vivo mouse model using continuous pulmonary airway pressure at different values.

  9. Lung-protective ventilation in neonatology.

    PubMed

    van Kaam, Anton

    2011-01-01

    Ventilator-induced lung injury (VILI) is considered an important risk factor in the development of bronchopulmonary dysplasia (BPD) and is primarily caused by overdistension (volutrauma) and repetitive opening and collapse (atelectrauma) of terminal lung units. Lung-protective ventilation should therefore aim to reduce tidal volumes, and recruit and stabilize atelectatic lung units (open lung ventilation strategy). This review will summarize the available evidence on lung-protective ventilation in neonatology, discussing both high-frequency ventilation (HFV) and positive pressure ventilation (PPV). It shows that HFV does not appear to have a clear benefit over PPV, although most studies failed to apply a true open lung ventilation strategy during HFV. The evidence on the optimal tidal volume, positive end-expiratory pressure and the role for lung recruitment during lung-protective PPV is extremely limited. Volume-targeted ventilation seems to be a promising mode in terms of lung protection, but more studies are needed. Due to the lack of convincing evidence, lung-protective ventilation and modes seem to be implemented in daily clinical practice at a slow pace.

  10. Preventing cervical cancer in low-resource settings: how far have we come and what does the future hold?

    PubMed

    Tsu, V D; Pollack, A E

    2005-05-01

    The Alliance for Cervical Cancer Prevention (ACCP) came together in 1999 to answer key research questions and to advocate for greater global and national interest in reducing the heavy burden of morbidity and mortality caused by this preventable disease. Visual inspection with acetic acid (VIA), visual inspection with Lugol's iodine (VILI), and human papillomavirus (HPV) tests have been shown to be viable alternatives to traditional cytology. ACCP experience confirmed that cryotherapy is a safe and effective method that is acceptable to women and can be delivered by a range of health providers, including nonphysicians. Programs can maximize coverage by accommodating local needs and involving community leaders and women in planning and implementation. Advocacy efforts have led to significant policy changes and galvanized support for cervical cancer prevention. Despite the prospect of new HPV vaccines, screening will be needed for at least the next 30-40 years. Our experience has shown that with creativity, flexibility, and well-focused use of resources, the inequitable burden of cervical cancer borne by women in poor countries can be sharply reduced.

  11. [Ventilator-associated pneumonia and other infections].

    PubMed

    Bobik, Piotr; Siemiątkowski, Andrzej

    2014-01-01

    One of the fundamental elements of therapy in patients hospitalised in the Intensive Care Unit (ICU) is mechanical ventilation (MV). MV enables sufficient gas exchange in patients with severe respiratory insufficiency, thus preserving the proper functioning of organs and systems. However, clinical and experimental studies show that mechanical ventilation may cause severe complications, e.g. lung injury (VALI, VILI), systemic inflammatory response syndrome (SIRS), and, on rare occasions, multiple organ failure (MOF). Mechanical ventilation and especially endotracheal intubation are associated also with higher risk of infectious complications of the respiratory system: ventilator-associated respiratory infection (VARI) and ventilator-associated pneumonia (VAP). The complications of the MV listed above have a significant influence on the length of treatment and also on the increase of the costs of therapy and mortality of patients who stay in an ICU. These negative effects of supported breathing are the reasons for intensive research to find new biological markers of inflammation and lung injury, more sensitive and specific diagnostic instruments, more effective methods of therapy, and programs of prevention. The purpose of this article is the presentation of current knowledge concerning VAP-related infections, to allow pulmonologists and general practitioners to become more familiar with the problem. Basic and the most important data concerning the definition, epidemiology, pathophysiology, microbiology, diagnostics, treatment, and prevention of VAP have been included. Additionally, ventilator-associated tracheobronchitis (VAT) was discussed.

  12. Syntheses of novel protein products (milkglyde, saliglyde, and soyglyde) from vegetable epoxy oils and gliadin.

    PubMed

    Harry-O'kuru, Rogers E; Mohamed, Abdellatif; Gordon, Sherald H; Xu, James

    2012-02-22

    The aqueous alcohol-soluble fraction of wheat gluten is gliadin. This component has been implicated as the causative principle in celiac disease, which is a physiological condition experienced by some infants and adults. The outcome of the ingestion of whole wheat products by susceptible individuals is malabsorption of nutrients resulting from loss of intestinal vili, the nutrient absorption regions of the digestive system. This leads to incessant diarrhea and weight loss in these individuals. Only recently has this health condition been properly recognized and accurately diagnosed in this country. The culprit gliadin is characterized by preponderant glutamine side-chain residues on the protein surface. Gliadin is commercially available as a wheat gluten extract, and in our search for new biobased and environmentally friendly products from renewable agricultural substrates, we have exploited the availability of the glutamine residues of gliadin as synthons to produce novel elastomeric nonfood products dubbed "milkglyde", "saliglyde", and soyglyde from milkweed, salicornia and soybean oils. The reaction is an amidolysis of the oxirane groups of derivatized milkweed, salicornia, and soybean oils under neat reaction conditions with the primary amide functionalties of glutamine to give the corresponding amidohyroxy gliadinyl triglycerides, respectively. The differential scanning calorimetry, thermogravimetric analyses, and rheological data from a study of these products indicate properties similar to those of synthetic rubber.

  13. New technologies and procedures for cervical cancer screening.

    PubMed

    Cuzick, Jack; Bergeron, Christine; von Knebel Doeberitz, Magnus; Gravitt, Patti; Jeronimo, Jose; Lorincz, Attila T; J L M Meijer, Chris; Sankaranarayanan, Rengaswamy; J F Snijders, Peter; Szarewski, Anne

    2012-11-20

    The clearly higher sensitivity and reproducibility of human papillomavirus (HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) has led to widespread calls to introduce it as the primary screening test. The main concern has been its lower specificity, due to the fact that it cannot separate transient from persistent infections, and only the latter are associated with an increased risk of high-grade CIN and cancer. Thus, even proponents of HPV testing generally only recommend it for women over the age of 30 years (or in some cases 35 years). If HPV testing is to reach its full potential, new approaches with better specificity are needed, either as triage tests for HPV positive women or, if the high sensitivity of HPV DNA testing can be maintained, as alternate primary screening modalities. Approaches that may useful in this regard, especially as triage tests, include HPV typing, methylation (and consequent silencing) of host and viral genes, and new cytologic methods, such as p16(INK4a) staining, which attempt to identify proliferating cells. At an earlier stage of development are direct methods based on detection of HPV E6 or E7 proteins. Recent progress and current status of these methods is discussed in this chapter. The current status of visual inspection (VIA and VILI) methods is also surveyed and progress on self-sampling is reviewed. This article forms part of a special supplement entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012. Copyright © 2012. Published by Elsevier Ltd.

  14. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury

    PubMed Central

    Mathew, Biji; Takekoshi, Daisuke; Sammani, Saad; Epshtein, Yulia; Sharma, Rajesh; Smith, Brett D.; Mitra, Sumegha; Desai, Ankit A.; Weichselbaum, Ralph R.; Garcia, Joe G. N.

    2015-01-01

    We previously reported protective effects of GADD45a (growth arrest and DNA damage-inducible gene 45 alpha) in murine ventilator-induced lung injury (VILI) via effects on Akt-mediated endothelial cell signaling. In the present study we investigated the role of GADD45a in separate murine models of radiation- and bleomycin-induced lung injury. Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a−/−) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a−/− mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt+/− mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. Additionally, overexpression of a constitutively active Akt1 transgene reversed RILI-susceptibility in GADD45a−/− mice. In separate studies, lung fibrotic changes 2 wk after treatment with bleomycin (0.25 U/kg IT) was significantly increased in GADD45a−/− mice compared with wild-type mice assessed by lung collagen content and histology. These data implicate GADD45a as an important modulator of lung inflammatory responses across different injury models and highlight GADD45a-mediated signaling as a novel target in inflammatory lung injury clinically. PMID:26498248

  15. Investigation of alveolar tissue deformations using OCT combined with fluorescence microscopy

    NASA Astrophysics Data System (ADS)

    Gaertner, Maria; Cimalla, Peter; Knels, Lilla; Meissner, Sven; Schnabel, Christian; Kuebler, Wolfgang M.; Koch, Edmund

    2011-06-01

    In critical care medicine, artificial ventilation is a life saving tool providing sufficient blood oxygenation to patients suffering from respiratory failure. Essential for their survival is the use of protective ventilation strategies to prevent further lung damage due to ventilator induced lung injury (VILI). Since there is only little known about implications of lung tissue overdistension on the alveolar level, especially in the case of diseased lungs, this research deals with the investigation of lung tissue deformation on a microscale. A combined setup utilizing optical coherence tomography (OCT) and confocal fluorescence microscopy, is used to study the elastic behavior of the alveolar tissue. Three-dimensional geometrical information with voxel sizes of 6 μm × 6 μm × 11 μm (in air) is provided by OCT, structural information about localization of elastin fibers is elucidated via confocal fluorescence microscopy with a lateral resolution of around 1 μm. Imaging depths of 90 μm for OCT and 20 μm for confocal fluorescence microscopy were obtained. Dynamic studies of subpleural tissue were carried out on the basis of an in vivo mouse model post mortem, mimicking the physiological environment of an intact thorax and facilitating a window for the application of optical methods. Morphological changes were recorded by applying constant positive airway pressures of different values. With this, alveolar volume changes could clearly be recognized and quantified to form a compliance value of 3.5 • 10-6(see manuscript). The distribution of elastin fibers was detected and will be subject to further elasticity analysis.

  16. Association Between Risky Sexual Behavior and Cervical Cancer Screening Among Women in Kenya: A Population-Based Study.

    PubMed

    Haile, Zelalem T; Kingori, Caroline; Chavan, Bhakti; Francescon, John; Teweldeberhan, Asli K

    2017-08-03

    Women residing in Eastern Africa are disproportionately affected by cervical cancer. Previous studies have identified risky sexual behavior as a major risk factor for cervical cancer. However, population-based studies examining the relationship between sexual behavior and cervical cancer screening are currently lacking. This descriptive cross-sectional study utilized nationally representative secondary data from the 2014 Kenya Demographic and Health Survey (n = 6104) to examine the association between risky sexual behavior and cervical cancer screening among sexually active women. Both descriptive and inferential statistical methods were utilized. Overall, 20.2% of the study sample reported having cervical cancer examination. Approximately 13.1% of the participants reported involvement in risky sexual behavior. Significantly lower proportion of women engaged in risky sexual behavior reported having cervical cancer examination (14.5 vs. 21.0%; p = 0.001). In the multivariable model, we found a significant interaction between risky sexual behavior and marital status on cervical cancer examination. Among women who were married/living together, risky sexual behavior was negatively associated with cervical cancer examination after adjusting for potential confounders (Prevalence Ratio, 95% CI) (0.42; 0.24-0.74; p = 0.002). The prevalence of having visual inspection with VIA or VILI were lower among women who were involved in risky sexual behavior (0.39; 0.18-0.87; p = 0.022). However, we were unable to detect any significant association between risky sexual behavior and having Papanicolaou test. With increasing incidence of cervical cancer in resource-limited settings, it is critical to identify populations at increased risk of infection and provide effective screening and follow-up services.

  17. Human-induced geomorphology: Modeling slope failure in Dominical, Costa Rica using Landsat imagery

    NASA Astrophysics Data System (ADS)

    Miller, Andrew J.

    Unchecked human development has ravaged the region between Dominical and Uvita, Costa Rica. Much of the development transition has been driven by tourism and further foreign direct investment in residential, service and commercial enterprises. The resulting land-use/land-cover change has removed traditional forest cover in exchange for impervious surfaces, physical structures, and bare ground which is no longer mechanically supported by woody vegetation. Combined with a tropical climate, deeply weathered soils and lithography which are prone to erosion, land cover change has led to an increase in slope failure occurrences. Given the remoteness of the Dominical-Uvita region, its rate of growth and the lack of monitoring, new techniques for monitoring land use and slope failure susceptibility are needed. Two new indices are presented here that employ a Digital Elevation Model (DEM) and widely available Landsat imagery to assist in this endeavor. The first index, or Vegetation Influenced Landslide Index (VILI), incorporates slope derived from a DEM and Lu et al.'s (2007) Surface Cover Index to quantify vegetative cover as a means of mechanical stabilization in landslide prone areas. The second index, or Slope Multiplier Index (SMI), uses individual Landsat data bands and basic Landsat band ratios as environmental proxies to replicate soil, vegetative and hydrologic properties. Both models achieve accuracy over 70% and rival results from more complicated published literature. The accuracy of the indices was assessed with the creation of a landslide inventory developed from field observations occurring in December 2007 and November 2008. The creation of these indices represents an efficient and accurate way of determining landslide susceptibility zonation in data poor areas where environmental protection practitioners may be overextended, under-trained or both.

  18. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.

    PubMed

    Mathew, Biji; Takekoshi, Daisuke; Sammani, Saad; Epshtein, Yulia; Sharma, Rajesh; Smith, Brett D; Mitra, Sumegha; Desai, Ankit A; Weichselbaum, Ralph R; Garcia, Joe G N; Jacobson, Jeffrey R

    2015-12-15

    We previously reported protective effects of GADD45a (growth arrest and DNA damage-inducible gene 45 alpha) in murine ventilator-induced lung injury (VILI) via effects on Akt-mediated endothelial cell signaling. In the present study we investigated the role of GADD45a in separate murine models of radiation- and bleomycin-induced lung injury. Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a(-/-)) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a(-/-) mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt(+/-) mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. Additionally, overexpression of a constitutively active Akt1 transgene reversed RILI-susceptibility in GADD45a(-/-) mice. In separate studies, lung fibrotic changes 2 wk after treatment with bleomycin (0.25 U/kg IT) was significantly increased in GADD45a(-/-) mice compared with wild-type mice assessed by lung collagen content and histology. These data implicate GADD45a as an important modulator of lung inflammatory responses across different injury models and highlight GADD45a-mediated signaling as a novel target in inflammatory lung injury clinically.

  19. Objective screening for cervical cancer in developing nations: lessons from Nigeria.

    PubMed

    Roblyer, Darren; Richards-Kortum, Rebecca; Park, Sun-Young; Adewole, Isaac; Follen, Michele

    2007-10-01

    In developed countries, cervical cancer screening programs have been highly successful. In the United States a 70% decrease in the mortality of cervical cancer has occurred since the 1960's largely due to the Papanicolaou test. However, it is not clear how best to translate these advances to developing countries, where cervical cancer remains the leading cause of cancer death for woman. Cytology-based screening, followed by colposcopic detection is expensive and requires extensive laboratory infrastructure and trained personnel, which are often unavailable in low resource settings. Techniques such as visual inspection with acetic acid (VIA) and visual inspection with Lugol's Iodine (VILI) are less expensive and require minimal supplies and infrastructure; however there are concerns that these approaches do not have adequate specificity without extensive provider training and experience. Objective cervical cancer screening techniques which are easy to interpret, provide rapid results, and have both high sensitivity and specificity would be highly beneficial in developing countries. We have developed a multispectral digital colposcope (MDC) which is designed to rapidly image the cervix and is used with automated image analysis algorithms that provide objective delineation of neoplastic areas. In this paper we describe an effort to implement this device in Ibadan, Nigeria, to determine the feasibility of conducting clinical trials using the MDC as an experimental screening device. Our aim was to test the device in a location where it might be most beneficial and to collect data useful for developing new, low-cost, low-maintenance devices. Multiple obstacles limited the success of imaging using the MDC in Nigeria including an unstable supply of electricity and a lack of available spare parts and tools. We conclude that these obstacles must be overcome by robust and simple device designs in order to successfully test an imaging-based screening device in Nigeria or other

  20. Amelioration of superoxide dismutase on ventilator-induced lung injury by suppressing leukocyte in the lungs and systemic circulation.

    PubMed

    Su, Chien-Ling; Du, Wen-Yuan; Chiang, Ling-Ling; Lin, Yen-Kuang; Lee, Hui-Ling; Chen, Kuan-Hao; Wang, Jiun-; Wang, David

    2013-08-31

    Superoxide dismutase (SOD) is a free radical scavenger and a broad-spectrum antioxidant. Its anti-inflammatory and immunomodulatory effects have recently been noted. We studied the effects of this antioxidant on lung damage, oxidative stress, and inflammation in a model of ventilator-induced lung injury (VILI), using 8- to 12-wk-old Sprange-Dawley rats (n = 40). Animals were randomized and evenly divided into two experimental groups, low tidal volume (V(T)) ventilation (V(T) = 9 ml/kg) and high V(T) ventilation (V(T) = 28 ml/kg). Each group was evenly divided into two subgroups: ten animals were treated with superoxide dismutase (SOD; 10,000 U/kg i.v., 2 h prior to the ventilation) and the rests were treated with vehicle. Lung injury was evaluated by histological examination, and cells counts of red blood cells (RBC) and white blood cells (WBC) in the alveoli and the septal wall thickness in lung tissues and serum lactate dehydrogenase (LDH). The lung permeability was assessed by the wet-to-dry weight ratio (W/D), lung weight to body weight ratio (LW/BW) and protein concentration in broncholavage fluid (BALF). Levels of oxidative stress and lipid peroxidation in the lungs were evaluated by tissue malondialdehyde (MDA) and methylguanidine (MG) in BALF, respectively. SOD pretreatment significantly decreased WBC counts in systemic circulation and in alveoli, and effectively attenuated high V(T) ventilation induced lung injury by reducing hyaline membrane development, septal wall thickness, lung W/D and LW/BW and serum LDH in relation to those of the control. In addition, lung tissues MDA and MG in BALF were also notably reduced.

  1. Web-based interactive access, analysis and comparison of remotely sensed and in situ measured temperature data

    NASA Astrophysics Data System (ADS)

    Eberle, Jonas; Urban, Marcel; Hüttich, Christian; Schmullius, Christiane

    2014-05-01

    Numerous datasets providing temperature information from meteorological stations or remote sensing satellites are available. However, the challenging issue is to search in the archives and process the time series information for further analysis. These steps can be automated for each individual product, if the pre-conditions are complied, e.g. data access through web services (HTTP, FTP) or legal rights to redistribute the datasets. Therefore a python-based package was developed to provide data access and data processing tools for MODIS Land Surface Temperature (LST) data, which is provided by NASA Land Processed Distributed Active Archive Center (LPDAAC), as well as the Global Surface Summary of the Day (GSOD) and the Global Historical Climatology Network (GHCN) daily datasets provided by NOAA National Climatic Data Center (NCDC). The package to access and process the information is available as web services used by an interactive web portal for simple data access and analysis. Tools for time series analysis were linked to the system, e.g. time series plotting, decomposition, aggregation (monthly, seasonal, etc.), trend analyses, and breakpoint detection. Especially for temperature data a plot was integrated for the comparison of two temperature datasets based on the work by Urban et al. (2013). As a first result, a kernel density plot compares daily MODIS LST from satellites Aqua and Terra with daily means from GSOD and GHCN datasets. Without any data download and data processing, the users can analyze different time series datasets in an easy-to-use web portal. As a first use case, we built up this complimentary system with remotely sensed MODIS data and in situ measurements from meteorological stations for Siberia within the Siberian Earth System Science Cluster (www.sibessc.uni-jena.de). References: Urban, Marcel; Eberle, Jonas; Hüttich, Christian; Schmullius, Christiane; Herold, Martin. 2013. "Comparison of Satellite-Derived Land Surface Temperature and Air

  2. Is the snow of yesterday, the flood of tomorrow?

    NASA Astrophysics Data System (ADS)

    Rössler, Ole; Weingartner, Rolf

    2014-05-01

    "The snow of yesterday, is the flood of tomorrow." This famous quote could just as much be a folk wisdom or a farmer's wisdom, but it describes the social awareness that the water of the winterly snow amounts may lead to flooding in the spring. Furthermore, this common experience finds its confirmation in reality - though only at a first glance. For example, in spring 1999, a major flooding occurred after a winter with the highest snow amounts recorded over the last 30 years. This is to forget that sustained rainfall occurred prior to the flood event. For scientists, the question remains whether and to what extent winterly snow contributes to spring flooding and how this information might help in forecasts. As snow depth measurements are insufficiently for an empirical study, we set up a hydrological model approach, combining the various snow conditions with the different spring weather conditions of the last 29 years (1981-2009). The study was conducted in three mesoscale (380-550 km2) headwater catchments in the Bernese Oberland. We set up the hydrological model WaSiM-ETH and validated the model against runoff and snow water equivalent. Then, we estimated the start of the melting season for each year following the approach of Egli and Jonas (2009). This date and the according SWE serves as the initial condition to model the spring runoff using all weather conditions during the last 29 years (until June). This leads to 841 possible spring runoff series. Assuming that the last 29 years represent a major part of the natural variance, the influence of snow on the spring discharge and the flood peak in specific is presented. We found that the snow amount and the flood peak are not directly correlated as suggested by the saying. But, the snow amount causes primarily higher mean flow values while the effect on spring flood peaks are a function of weather. Thereby, snow conditions primarily alter the disposition of the catchments to a flood event. We estimate the

  3. How can video supported reflection enhance teachers' professional development?

    NASA Astrophysics Data System (ADS)

    McCullagh, John F.

    2012-03-01

    This paper responds to Eva Lundqvist, Jonas Almqvist and Leif Ostman's account of how the manner of teaching can strongly influence pupil learning by recommending video supported reflection as a means by which teachers can transform the nature of their practice. Given the complex nature of the many conditions which influence and control teachers' actions the reframing of routine practice through reflection-in-action can prove challenging. This response paper describes how video can empower teachers to take greater control of their progress and allows for a more social constructivist approach to professional development. Along with a consideration of the difficulties associated with the notion of `reflection' and a short case study, the paper uses Lev Semenovich Vygotsky's zone of proximal development and the notion of scaffolding to propose that video offers a Video Supported Zone of Proximal Development which can ease the process of teacher development. In capturing permanent and exchangeable representations of practice video encourages a collaborative approach to reflection and is consistent with the original ideas of John Dewey.

  4. Dressed Quark Mass Dependence of Pion and Kaon Form Factors

    SciTech Connect

    Ninomiya, Y.; Bentz, W.; Cloet, I. C.

    2015-02-04

    The structure of hadrons is described well by the Nambu-Jona-Lasinio (NJL) model, which is a chiral effective quark theory of QCD. In this work we explore the electromagnetic structure of the pion and kaon using the three-flavor NJL model in the proper-time regularization scheme, including effects of the pion cloud at the quark level. In the calculation there is only one free parameter, which we take as the dressed light quark (u and d) mass. In the regime where the dressed light quark mass is approximately 0.25 GeV we find that the calculated values of the kaon decay constant, current quark masses, and quark condensates are consistent with experiment- and QCD-based analyses. We also investigate the dressed light quark mass dependence of the pion and kaon electromagnetic form factors, where comparison with empirical data and QCD predictions also favors a dressed light quark mass near 0.25 GeV.

  5. Light mesons on the light front

    SciTech Connect

    Naito, K.; Maedan, S.; Itakura, K.

    2004-11-01

    We study the properties of light mesons in the scalar, pseudoscalar, and vector channels within the light-front quantization, by using the (one flavor) Nambu-Jona-Lasinio model with vector interaction. After taking into account the effects of chiral symmetry breaking, we derive the bound-state equation in each channel in the large N limit (N is the number of colors), which means that we consider the lowest qq Fock state with the constituent quark and antiquark. By solving the bound-state equation, we simultaneously obtain a mass and a light cone (LC) wave function of the meson. While we reproduce the previous results for the scalar and pseudoscalar mesons, we find that, for a vector meson, the bound-state equations for the transverse and longitudinal polarizations look different from each other. However, eventually after imposing a cutoff which is invariant under the parity and boost transformations, one finds these two are identical, giving the same mass and the same (spin-independent) LC wave function. When the vector interaction becomes larger than a critical value, the vector state forms a bound state, whose mass decreases as the interaction becomes stronger. While the LC wave function of the pseudoscalar meson is broadly distributed in longitudinal momentum (x) space, that of the vector meson is squeezed around x=1/2.

  6. Current Fluctuations in One Dimensional Diffusive Systems with a Step Initial Density Profile

    NASA Astrophysics Data System (ADS)

    Derrida, Bernard; Gerschenfeld, Antoine

    2009-12-01

    We show how to apply the macroscopic fluctuation theory (MFT) of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim to study the current fluctuations of diffusive systems with a step initial condition. We argue that one has to distinguish between two ways of averaging (the annealed and the quenched cases) depending on whether we let the initial condition fluctuate or not. Although the initial condition is not a steady state, the distribution of the current satisfies a symmetry very reminiscent of the fluctuation theorem. We show how the equations of the MFT can be solved in the case of non-interacting particles. The symmetry of these equations can be used to deduce the distribution of the current for several other models, from its knowledge (Derrida and Gerschenfeld in J. Stat. Phys. 136, 1-15, 2009) for the symmetric simple exclusion process. In the range where the integrated current Qt˜sqrt{t} , we show that the non-Gaussian decay exp [- Q {/t 3}/ t] of the distribution of Q t is generic.

  7. Critical Stability in Nuclei - An Old Problem Revisited

    NASA Astrophysics Data System (ADS)

    Moszkowski, S. A.

    In this paper we will focus on the nucleon-nucleon interaction in relative S-states. The 1S0 interaction is known to be close to that for critical two-body binding. We will discuss two approaches to the NN interaction, which are equivalent on-shell but not off-shell. There is a well-defined transformation between these approaches [1]. One (my preferred approach) is to minimize the tensor forces far off-shell, which leads to more rapid convergence, but at the price of significant non-locality. This approach is used in a model of relativistic tensor quenching of OPEP [2]. With non-local NN interactions it is possible to fit not only NN observables, but also the NNN ground-state energies [3]. The other approach is to maximize the role of the π and keep the interaction as local as possible [4]. This approach is also internally consistent, but requires additional NNN interactions to fit nuclear data. Also, we discuss briefly a so-called low momentum interaction [5, 6], which fits S-wave phase shifts quite well. This interaction is strongly non-local, and it can be approximated by a schematic separable interaction. Finally, we mention the Nambu-Jona-Lasinio model [7] and a good approximation, the Hulthen potential, which provides some insight into the near critical two-body binding.

  8. Reduction of adsorption capacity of coconut shell activated carbon for organic vapors due to moisture contents.

    PubMed

    Abiko, Hironobu; Furuse, Mitsuya; Takano, Tsuguo

    2010-01-01

    In occupational hygiene, activated carbon produced from coconut shell is a common adsorbent material for harmful substances including organic vapors due to its outstanding adsorption capacity and cost advantage. However, moisture adsorption of the carbon generally decreases the adsorption capacity for organic vapors. In a previous report, we prepared several coconut shell activated carbons which had been preconditioned by equilibration with moisture at different relative humidities and measured the breakthrough times for 6 kinds of organic vapor, in order to clarify the effect of preliminary moisture content in activated carbon on the adsorption capacity in detail. We found that the relative percent weight increase due to moisture adsorption of the carbon specimen had a quantitative effect, reducing the breakthrough time. In this report, we carried out further measurements of the effect of moisture content on the adsorption of 13 kinds of organic vapor, and investigated the relationship between moisture adsorption and the reduction of the breakthrough time of activated carbon specimens. We also applied the data to the Wood's breakthrough time estimation model which is an extension of the Wheeler-Jonas equation.

  9. Modeling charmonium-η decays of JP C=1- higher charmonia

    NASA Astrophysics Data System (ADS)

    Anwar, Muhammad Naeem; Lu, Yu; Zou, Bing-Song

    2017-06-01

    We propose a new model to create a light meson in the heavy quarkonium transition, which is inspired by the Nambu-Jona-Lasinio (NJL) model. Hadronic transitions of JP C=1- higher charmonia with the emission of an η meson are studied in the framework of the proposed model. The model shows its potential to reproduce the observed decay widths and make predictions for the unobserved channels. We present our predictions for the decay width of Ψ →J /ψ η and Ψ →hc(1 P )η , where Ψ are higher S and D wave vector charmonia, which provide useful references to search for higher charmonia and determine their properties in forthcoming experiments. The predicted branching fraction B (ψ (4415 )→hc(1 P )η )=4.62 ×10-4 is one order of magnitude smaller than the J /ψ η channel. Estimates of partial decay width Γ (Y →J /ψ η ) are given for Y (4360 ), Y (4390 ), and Y (4660 ) by assuming them as c c ¯ bound states with quantum numbers 33D1, 33D1, and 53S1, respectively. Our results are in favor of these assignments for Y (4360 ) and Y (4660 ). The corresponding experimental data for these Y states has large statistical errors which do not provide any constraint on the mixing angle if we introduce S -D mixing. To identify Y (4390 ), precise measurements on its hadronic branching fraction are required which are eagerly awaited from BESIII.

  10. Derivation of Transport Equations for a Strongly Interacting Lagrangian in Powers of ħand 1/ Nc

    NASA Astrophysics Data System (ADS)

    Klevansky, S. P.; Ogura, A.; Hüfner, J.

    1997-11-01

    Transport theory for an interacting fermionic system is reviewed and applied to the chiral Lagrangian of the Nambu-Jona-Lasinio model. Two expansions must be applied: an expansion in the inverse number of colors, 1/Nc, due to the nature of the strong coupling theory, and a semiclassical expansion, in powers of ħ. The quasiparticle approximation is implemented at an early stage, and spin effects are omitted. The self-energy is evaluated, self-consistently only in the Hartree approximation, and semi-perturbatively in the collision integral. In the Hartree approximation,O((1/Nc)0), the Vlasov equation is recovered toO(ħ1), together with an on-mass shell constraint equation, that is automatically fulfilled by the quasiparticle ansatz. The expressions for the self-energy to orderO((1/Nc)) lead to the collision term. Here one sees explicitly that particle-antiparticle creation and annihilation processes are suppressed that would otherwise be present, should an off-shell energy spectral function be admitted. A clear identification of thes,tanduchannel scattering processes in connection with the self-energy graphs is made and the origin of the mixed terms is made evident. Finally, after ordering according to powers in ħ, a Boltzmann-like form for the collision integral is obtained.

  11. Collective modes in the color flavor-locked phase

    NASA Astrophysics Data System (ADS)

    Anglani, Roberto; Mannarelli, Massimo; Ruggieri, Marco

    2011-05-01

    We study the low-energy effective action for some collective modes of the color flavor-locked (CFL) phase of QCD. This phase of matter has long been known to be a superfluid because by picking a phase its order parameter breaks the quark-number U(1)B symmetry spontaneously. We consider the modes describing fluctuations in the magnitude of the condensate, namely the Higgs mode, and in the phase of the condensate, namely the Nambu-Goldstone (NG) (or Anderson-Bogoliubov) mode associated with the breaking of U(1)B. By employing as microscopic theory the Nambu-Jona-Lasinio model, we reproduce known results for the Lagrangian of the NG field to the leading order in the chemical potential and extend such results evaluating corrections due to the gap parameter. Moreover, we determine the interaction terms between the Higgs and the NG field. This study paves the way for a more reliable study of various dissipative processes in rotating compact stars with a quark matter core in the CFL phase.

  12. Nambu sum rule and the relation between the masses of composite Higgs bosons

    NASA Astrophysics Data System (ADS)

    Volovik, G. E.; Zubkov, M. A.

    2013-04-01

    We review the known results on the bosonic spectrum in various Nambu-Jona-Lasinio models both in condensed matter physics and in relativistic quantum field theory including He3-B, He3-A, the thin films of superfluid He3, and QCD (Hadronic phase and the color-flavor locking phase). Next, we calculate the bosonic spectrum in the relativistic model of top quark condensation suggested in [Phys. Lett. B 221, 177 (1989)PYLBAJ0370-269310.1016/0370-2693(89)91494-9]. In all considered cases, the sum rule appears, which relates the masses (energy gaps) Mboson of the bosonic excitations in each channel with the mass (energy gap) of the condensed fermion Mf as ∑Mboson2=4Mf2. Previously, this relation was established by Nambu for He3-B and for the s-wave superconductor. We generalize this relation to the wider class of models and call it the Nambu sum rule. We discuss the possibility to apply this sum rule to various models of top quark condensation. In some cases, this rule allows us to calculate the masses of extra Higgs bosons that are the Nambu partners of the 125 GeV Higgs.

  13. Vector Interaction Enhanced Bag Model for Astrophysical Applications

    NASA Astrophysics Data System (ADS)

    Klähn, Thomas; Fischer, Tobias

    2015-09-01

    For quark matter studies in astrophysics the thermodynamic bag model (tdBAG) has been widely used. Despite its success it fails to account for various phenomena expected from QCD. We suggest a straightforward extension of tdBAG in order to take the dynamical breaking of chiral symmetry and the influence of vector interactions explicitly into account. As for tdBAG the model mimics confinement in a phenomenological approach. It is based on an analysis of the Nambu-Jona-Lasinio (NJL) model at finite density. Furthermore, we demonstrate how NJL and bag models in this regime follow from the more general and QCD-based framework of the Dyson-Schwinger equations in a medium by assuming simple gluon contact interaction. Based on our simple and novel model, we construct quark hadron hybrid equations of state and systematically study chiral and deconfinement phase transitions, the appearance of s-quarks, and the role of vector interaction. We further study these aspects for matter in β-equilibrium at zero temperature, with particular focus on the current ˜2 {M}⊙ maximum mass constraint for neutron stars. Our approach indicates that the currently only theoretical evidence for the hypothesis of stable strange matter is an artifact of tdBAG and results from neglecting the dynamical breaking of chiral symmetry.

  14. Effect of temperature and magnetic field on two-flavor superconducting quark matter

    NASA Astrophysics Data System (ADS)

    Mandal, Tanumoy; Jaikumar, Prashanth

    2016-10-01

    We investigate the effect of turning on temperature for the charge neutral phase of two-flavor color superconducting (2SC) dense quark matter in the presence of constant external magnetic field. Within the Nambu-Jona-Lasinio model, by tuning the diquark coupling strength, we study the interdependent evolution of the quark Bardeen-Cooper-Schrieffer gap and dynamical mass as functions of temperature and magnetic field. We find that magnetic field B ≳0.02 GeV2 (1 018 G ) leads to anomalous temperature behavior of the gap in the gapless 2SC phase (moderately strong coupling), reminiscent of previous results in the literature found in the limit of weak coupling without magnetic field. The 2SC gap in the strong coupling regime is abruptly quenched at ultrahigh magnetic field due to the mismatched Fermi surfaces of up and down quarks imposed by charge neutrality and oscillation of the gap due to Landau level quantization. The dynamical quark mass also displays strong oscillation and magnetic catalysis at high magnetic field, although the latter effect is tempered by nonzero temperature. We discuss the implications for newly born compact stars with superconducting quark cores.

  15. Polio and Nobel prizes: looking back 50 years.

    PubMed

    Norrby, Erling; Prusiner, Stanley B

    2007-05-01

    In 1954, John Enders, Thomas Weller, and Frederick Robbins were awarded the Nobel Prize in Physiology or Medicine "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue."5370 This discovery provided for the first time opportunities to produce both inactivated and live polio vaccines. By searching previously sealed Nobel Committee archives, we were able to review the deliberations that led to the award. It appears that Sven Gard, who was Professor of Virus Research at the Karolinska Institute and an adjunct member of the Nobel Committee at the time, played a major role in the events leading to the awarding of the Prize. It appears that Gard persuaded the College of Teachers at the Institute to decide not to follow the recommendation by their Nobel Committee to give the Prize to Vincent du Vigneaud. Another peculiar feature of the 1954 Prize is that Weller and Robbins were included based on only two nominations submitted for the first time that year. In his speech at the Nobel Prize ceremony, Gard mentioned the importance of the discovery for the future production of vaccines, but emphasized the implications of this work for growing many different, medically important viruses. We can only speculate on why later nominations highlighting the contributions of scientists such as Jonas Salk, Hilary Koprowski, and Albert Sabin in the development of poliovirus vaccines have not been recognized by a Nobel Prize.

  16. Vacuum polarization corrections to low energy quark effective couplings

    NASA Astrophysics Data System (ADS)

    Paulo, Ademar; Braghin, Fabio L.

    2014-07-01

    In this work corrections to low energy punctual effective quark couplings up to the eighth order are calculated by considering vacuum polarization effects with the scalar quark-antiquark condensate. The departing point is a QCD-based Nambu-Jona-Lasinio model. By separating the quark field into two components, one that condenses and another one for interacting quarks, the former is integrated out with the help of usual auxiliary fields and an effective action in terms of interacting quark fields is found. The scalar auxiliary field reduces to the quark-antiquark condensate in the vacuum and the determinant is expanded in powers of the quark-antiquark bilinears generating chiral invariant effective 2N-quark interactions (N =2,3…). The corresponding coupling constants and effective masses are estimated, and the general trend is that for increasing the effective gluon mass the values of the effective coupling constants decrease. All the values are in good agreement with phenomenological fits.

  17. Model prediction for temperature dependence of meson pole masses from lattice QCD results on meson screening masses

    NASA Astrophysics Data System (ADS)

    Ishii, Masahiro; Kouno, Hiroaki; Yahiro, Masanobu

    2017-06-01

    We propose a practical effective model by introducing temperature (T ) dependence to the coupling strengths of four-quark and six-quark Kobayashi-Maskawa-'t Hooft interactions in the 2 +1 flavor Polyakov-loop extended Nambu-Jona-Lasinio model. The T dependence is determined from lattice QCD (LQCD) data on the renormalized chiral condensate around the pseudocritical temperature Tcχ of chiral crossover and the screening-mass difference between π and a0 mesons in T >1.1 Tcχ where only the U (1 )A-symmetry breaking survives. The model well reproduces LQCD data on screening masses Mξscr(T ) for both pseudoscalar mesons (ξ =π ,K ,η ,η' ) and scalar ones (ξ =a0,κ ,σ ,f0 ), particularly in T ≳Tcχ . Using this effective model, we predict meson pole masses Mξpole(T ) for scalar and pseudoscalar mesons. For η' meson, the prediction is consistent with the experimental value at finite T measured in heavy-ion collisions. We point out that the relation Mξscr(T )-Mξpole(T )≈Mξ' scr(T )-Mξ' pole(T ) is pretty good when ξ and ξ' are the scalar mesons, and show that the relation Mξscr(T )/Mξ' scr(T )≈Mξpole(T )/Mξ' pole(T ) is well satisfied within 20% error when ξ and ξ' are the pseudoscalar mesons and also when ξ and ξ' are the scalar mesons.

  18. The origin of the self-organization of the 2D Euler fluid flows

    NASA Astrophysics Data System (ADS)

    Spineanu, Florin; Vlad, Madalina

    2011-11-01

    The 2D ideal incompressible fluid is usually described in terms of streamfunction, velocity and vorticity. An equivalent model consists of a discrete set of point-like vortices interacting in plane by a long-range potential. The essential property of the latter model is that it re-formulates the description in terms of matter, field and interaction. We first extend the model to reflect the parity-invariance and show that returning to continuum it leads to a field-theoretical formulation, with a Lagrangian density for a nonlinear scalar (matter) field, a gauge field and their minimal interaction. A fundamental property of the 2D Euler fluid is revealed in this way: the extremum of the action functional shows Self-Duality, a property known to generate coherent structures (almost all known solitons and instantons in the natural systems). We derive analytically the sinh-Poisson equation, governing the stationary states at relaxation.The presence of the Chern- Simons part in the Lagrangian explains why in 3D the fluid will never relax to a stationary coherent flow. Connections with 4D fermion systems (Nambu-Jona-Lasinio) and with surfaces of constant mean curvature (CMC) will be presented. Stability of certain regular flows results from the property of non-self- intersection of CMC surfaces embedded in 3D space. Partially supported by CNCSIS-UEFISCDI, PNII - IDEI 1104/2008.

  19. Ab initio calculations of the thermodynamics and phase diagram of zirconium

    NASA Astrophysics Data System (ADS)

    Hao, Yan-Jun; Zhang, Lin; Chen, Xiang-Rong; Cai, Ling-Cang; Wu, Qiang; Alfè, Dario

    2008-10-01

    The finite-temperature density-functional theory and quasiharmonic lattice dynamics are used to calculate the Gibbs free energy and quasiharmonic phonons of the hexagonal-close-packed (hcp) and omega (ω) crystal structures for Zr. The hcp phonon dispersions agree with experiment; the ω phonon dispersions have not been measured yet. From the free energy, the volume thermal expansion coefficients of α-Zr are predicted. The calculated volume thermal expansion coefficients for α-Zr are in good agreement with the experiment data at T>100K . Our calculated results found that at zero-temperature the lowest-energy phase is not the ω but the hcp phase. This conclusion is in accordance with the result of Schnell and Albers, but in disagreement with those of Ahuja and Jona and Marcus. The predicted phase boundary of α→ω is in good agreement with the available experiment; however, other theoretical results are far from the experiment at high temperatures.

  20. Spin-dependent structure functions in nuclear matter and the polarized EMC effect

    SciTech Connect

    I.C. Cloet; W. Bentz; A.W. Thomas

    2005-04-01

    An excellent description of both spin-independent and spin-dependent quark distributions and structure functions has been obtained with a modified Nambu-Jona-Lasinio model, which is free of unphysical thresholds for nucleon decay into quarks--hence incorporating an important aspect of confinement. We utilize this model to investigate nuclear medium modifications to structure functions, and find that we are readily able to reproduce both nuclear matter saturation and the experimental F{sub 2N}{sup A}/F{sub 2N} ratio, that is, the EMC effect. Applying this framework to determine g{sub 1p}{sup A}, we find that the ratio g{sub 1p}{sup A}/g{sub 1p} differs significantly from 1, with the quenching caused by the nuclear medium being about twice that of the spin-independent case. This represents an exciting result, which if confirmed experimentally, will reveal much about the quark structure of nuclear matter.

  1. On the 100th anniversary of sterile catgut kuhn: Franz Kuhn (1866-1929) and the epistemology of catgut sterilization.

    PubMed

    Dietz, Ulrich A; Kehl, Franz; Hamelmann, Wulf; Weisser, Christoph

    2007-12-01

    The long road to effective catgut sterilization began with the work of Lord Joseph Lister (1867) and did not end until 40 years later. At the end of the nineteenth century dozens of different techniques were used to "sterilize" catgut, by immersing the cord in a cold chemical solution, by exposing it to steam, or by a combination of the two techniques, yet none of these approaches offered the ultimate solution. One of the many physicians working on the catgut problem at that time was the German surgeon Franz Kuhn (1866-1929), best known as a pioneer of intubation anesthesia. This review offers a brief biographical sketch of Kuhn's life and career on the occasion of the centenary of Sterile Catgut Kuhn. The goal of the present study is to describe several landmarks in the development of the catgut sterilization method. To explain this process, two approaches are taken: first, an analysis to see whether the character traits of the typical surgeon at that time provided the soil in which innovation could thrive, and second, an epistemological examination of the conceptual models for the attainment of knowledge current at that time. Perspectives for the future are explored in light of the "imperative of responsibility" of Hans Jonas.

  2. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

    PubMed Central

    Meliopoulos, Victoria A.; Andersen, Lauren E.; Birrer, Katherine F.; Simpson, Kaylene J.; Lowenthal, John W.; Bean, Andrew G. D.; Stambas, John; Stewart, Cameron R.; Tompkins, S. Mark; van Beusechem, Victor W.; Fraser, Iain; Mhlanga, Musa; Barichievy, Samantha; Smith, Queta; Leake, Devin; Karpilow, Jon; Buck, Amy; Jona, Ghil; Tripp, Ralph A.

    2012-01-01

    Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome-wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta-analysis of findings from genome-wide RNAi screens has shown influenza virus to be dependent on functional nodes in host cell pathways, requiring a wide variety of molecules and cellular proteins for replication. Because rapid evolution of the influenza A viruses persistently complicates the effectiveness of vaccines and therapeutics, a further understanding of the complex host cell pathways coopted by influenza virus for replication may provide new targets and strategies for antiviral therapy. RNAi genome screening technologies together with bioinformatics can provide the ability to rapidly identify specific host factors involved in resistance and susceptibility to influenza virus, allowing for novel disease intervention strategies.—Meliopoulos, V. A., Andersen, L. E., Birrer, K. F., Simpson, K. J., Lowenthal, J. W., Bean, A. G. D., Stambas, J., Stewart, C. R., Tompkins, S. M., van Beusechem, V. W., Fraser, I., Mhlanga, M., Barichievy, S., Smith, Q., Leake, D., Karpilow, J., Buck, A., Jona, G., Tripp, R. A. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. PMID:22247330

  3. Immunology in Pittsburgh.

    PubMed

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time.

  4. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    NASA Astrophysics Data System (ADS)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2017-02-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates (10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass (α ) transition and the secondary (β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  5. What you don't know about vaccines can hurt you.

    PubMed

    Pace, Victor M

    2015-01-01

    As physicians, we've all learned in detail about the science behind vaccinations, but I suspect few of us have been taught about the history of vaccinations. Sure, we all know that Dr. Jonas Salk developed the poliovirus vaccine, but I wasn't aware that he inoculated himself, his wife, and his three children with his then experimental vaccine. When our editorial committee decided to focus on vaccinations as our theme for this month's Greene County Medical Society's Journal, I perused the internet for interesting topics. I came across a fascinating website, historyofvaccines.org; this website is a project of the College of Physicians of Philadelphia, touted as being the oldest professional medical organization in the United States. I credit the majority of the information in this article to the above website and the rest to the National Institutes of Health (nih.gov) website; I trust that the information is valid and true, based on the agencies behind these websites. Below are some interesting tidbits about vaccine preventable diseases that I found noteworthy to pass on to our readers.

  6. Thermo-magnetic nonlocal NJL model in the real and imaginary time formalisms

    NASA Astrophysics Data System (ADS)

    Márquez, F.; Zamora, R.

    2017-02-01

    In this paper, we study a nonlocal Nambu-Jona-Lasinio (nNJL) model with a Gaussian regulator in presence of a uniform magnetic field. We take a mixed approach to the incorporation of temperature in the model, and consider aspects of both real and imaginary time formalisms. We include confinement in the model through the quasiparticle interpretation of the poles of the propagator. By working in the real time formalism and computing the spectral density function, we find that the effect of the magnetic field on the poles of the propagator can be entirely absorbed within the mean field value of the scalar field. The analytic structure of our propagator is then preserved in the weak magnetic field limit. The effect of the magnetic field in the deconfinement phase transition is then studied. It is found that, like with chiral symmetry restoration, magnetic catalysis occurs for the deconfinement phase transition. It is also found that the magnetic field enhances the thermodynamical instability of the system. We work in the weak field limit, i.e. (eB) < 5mπ2. At this level there is no splitting of the critical temperatures for chiral and deconfinement phase transitions.

  7. Pion and σ-meson Properties in a Strong Magnetic Field

    NASA Astrophysics Data System (ADS)

    Zhang, Rui; Fu, Wei-Jie; Liu, Yu-Xin

    2015-09-01

    With the Nambu-Jona-Lasinio (NJL) model we calculate the properties of pion and σ-meson at finite temperature and finite magnetic field. The obtained temperature and magnetic field strength dependence of the constituent quark mass M, the pion and σ-meson masses and the neutral pion decay constant indicates that, in the simple four fermion interaction model, there exists the magnetic catalysis effect. It also shows that the Gell-Mann-Oakes-Renner relation is violated obviously with the increasing of the temperature, and the effect of the magnetic field becomes pronounced only around the critical temperature. The deviation of the critical temperatures obtained with different criteria indicates that the chiral phase transition driven by the temperature in the magnetic field strength region we have considered is in fact a crossover. Supported by the National Natural Science Foundation of China under Grant Nos. 10935001, 11175004, and 11435001, and the National Key Basic Research Program of China under Grant Nos. G2013CB834400 and G2015CB856900

  8. Quark matter in a parallel electric and magnetic field background: Chiral phase transition and equilibration of chiral density

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.

    2016-05-01

    In this article, we study spontaneous chiral symmetry breaking for quark matter in the background of static and homogeneous parallel electric field E and magnetic field B . We use a Nambu-Jona-Lasinio model with a local kernel interaction to compute the relevant quantities to describe chiral symmetry breaking at a finite temperature for a wide range of E and B . We study the effect of this background on the inverse catalysis of chiral symmetry breaking for E and B of the same order of magnitude. We then focus on the effect of the equilibration of chiral density n5 , produced dynamically by an axial anomaly on the critical temperature. The equilibration of n5 , a consequence of chirality-flipping processes in the thermal bath, allows for the introduction of the chiral chemical potential μ5, which is computed self-consistently as a function of the temperature and field strength by coupling the number equation to the gap equation and solving the two within an expansion in E /T2 , B /T2 , and μ52/T2 . We find that even if chirality is produced and equilibrates within a relaxation time τM , it does not change drastically the thermodynamics, with particular reference to the inverse catalysis induced by the external fields, as long as the average μ5 at equilibrium is not too large.

  9. Phase diagram of QCD in a magnetic field

    NASA Astrophysics Data System (ADS)

    Andersen, Jens O.; Naylor, William R.; Tranberg, Anders

    2016-04-01

    Recent advances in our understanding of the phase structure and the phase transitions of hadronic matter in strong magnetic fields B and zero quark chemical potentials μf are reviewed in detail. Many aspects of QCD are described using low-energy effective theories and models such as the bag model, the hadron resonance gas model, chiral perturbation theory (χ PT ), the Nambu-Jona-Lasinio (NJL) model, the quark-meson (QM) model, and Polyakov-loop extended versions of the NJL and QM models. Their properties and applications are critically examined. This includes mean-field calculations as well as approaches beyond the mean-field approximation such as the functional renormalization group. Renormalization issues are discussed and the influence of the vacuum fluctuations on the chiral phase transition is pointed out. At T =0 , model calculations and lattice simulations predict magnetic catalysis: The quark condensate increases as a function of the magnetic field. This is covered in detail. Recent lattice results for the thermodynamics of non-Abelian gauge theories with emphasis on S U (2 )c and S U (3 )c are also discussed. In particular, inverse magnetic catalysis around the transition temperature Tc as a competition between contributions from valence quarks and sea quarks resulting in a decrease of Tc as a function of B is focused on. Finally, recent efforts to modify models in order to reproduce the behavior observed on the lattice are discussed.

  10. Studies of Wigner-Weyl solution and external magnetic field in an NJL model

    NASA Astrophysics Data System (ADS)

    Wang, Qing-Wu; Cui, Zhu-Fang; Zong, Hong-Shi

    2016-11-01

    In this paper, we explore the dynamical chiral symmetry breaking by employing a two-flavor Nambu-Jona-Lasinio (NJL) model with constant external magnetic field. After changing the coupling strength of the NJL model, we found that the Wigner-Weyl solution and Nambu-Goldstone solution of the gap equation could coexist. Even though the gap equation only has Nambu-Goldstone solution at zero temperature, the Wigner-Weyl solution may appear when magnetic field strength and temperature are nonzero. For the Nambu-Goldstone solution, magnetic field and temperature have opposite impact on the chiral dynamical mass. In the chiral limit, the magnetic field dependence of chiral dynamical mass reveals the existence of inverse magnetic catalysis for the Wigner-Weyl solution. However, the two phases have different responses to the magnetic field and temperature in the chiral limit but the same beyond chiral limit. Furthermore, the order of the transition from the Nambu-Goldstone phase to Wigner-Weyl phase depends on the choice of model parameters. We have also calculated the susceptibilities of dynamical mass with respect to the temperature.

  11. Chiral phase transition and Schwinger mechanism in a pure electric field

    NASA Astrophysics Data System (ADS)

    Cao, Gaoqing; Huang, Xu-Guang

    2016-01-01

    We systematically study the chiral symmetry breaking and restoration in the presence of a pure electric field in the Nambu-Jona-Lasinio model at finite temperature and baryon chemical potential. In addition, we also study the effect of the chiral phase transition on the charged pair production due to the Schwinger mechanism. For these purposes, a general formalism for parallel electric and magnetic fields is developed at finite temperature and chemical potential for the first time. In the pure electric field limit B →0 , we compute the order parameter, the transverse-to-longitudinal ratio of the Goldstone mode velocities, and the Schwinger pair production rate as functions of the electric field. The inverse catalysis effect of the electric field to chiral symmetry breaking is recovered. And the Goldstone mode is found to disperse anisotropically such that the transverse velocity is always smaller than the longitudinal one, especially at nonzero temperature and baryon chemical potential. As expected, the quark-pair production rate is greatly enhanced by the chiral symmetry restoration.

  12. Strange quark matter in the presence of explicit symmetry breaking interactions

    NASA Astrophysics Data System (ADS)

    Moreira, J.; Morais, J.; Hiller, B.; Osipov, A. A.; Blin, A. H.

    2015-06-01

    It is shown that a first-order transition associated with a jump in the strange-quark mass appears in a generalized three-flavor Nambu-Jona-Lasinio treatment of quark matter. The generalization of the Lagrangian displays the complete set of spin-0 interactions at leading and subleading orders (LO and NLO) in 1/Nc counting, including the recently derived NLO explicit chiral symmetry breaking interactions which are of the same order as the 't Hooft flavor determinant. The parameters of the model are tightly constrained by the low-energy characteristics in both the pseudoscalar and scalar meson sectors. The transition occurs in a moderate chemical potential region (μ ≃400 MeV for zero temperature) in addition to the usual chiral transition associated with the light-quark sector. This feature has at its root the inclusion of the explicit chiral symmetry breaking interactions, which therefore can be seen to act as a catalyst in the production of strange-quark matter when compared to the conventional version of the model that takes only into account the 't Hooft interaction in the NLO. It can be traced back to the effect of the interactions which do not violate the Okubo-Zweig-Iizuka rule, without which the empirical ordering of the scalars (mK⋆

  13. [Sigmund Freud and the "Zeitschrift für Hypnotismus"].

    PubMed

    Tanner, Terence A

    2005-01-01

    While Freud was always ready to acknowledge the debt that psychoanalysis owed to hypnotism, his engagement in its study and medical application is often seen by historians as little more than a passing phase on the way to psychoanalysis proper. This paper attempts to redress the balance by exploring Freud's association with the most influential German-language journal devoted to hypnotism, the Zeitschrift für Hypnotismus. Freud not only contributed a paper to this periodical but also served on its editorial board for the first three years of its existence. There also appeared in the journal one review and six abstracts of his work. After a condensed bibliographical account of the journal, a summary is given of Freud's intellectual and professional contacts and exchanges with three of the key individuals associated with it: August Forel, Jonas Grossmann and Oskar Vogt. Finally clarification is given of the publication history of the "Dora" case history and the chronology of its rejection for publication by Korbinian Brodmann, editor of the journal when it became the Journal für Psychologie und Neurologie.

  14. Believing doesn't make it so: forensic education and the search for truth.

    PubMed

    Scott, Charles L

    2013-01-01

    The American Academy of Psychiatry and the Law (AAPL) was organized in 1969, in large part through the efforts of Dr. Jonas Rappeport. The founders of AAPL emphasized that an important purpose of the organization was to advance knowledge in the area of psychiatry and the law. The science of forensic psychiatry has since been vigorously debated. In 2005, Congress enacted a statute authorizing the National Academy of Sciences (NAS) to conduct a study on the state of the forensic sciences in the United States. As a result of this legislation, a forensic science committee was formed, and the report, "Strengthening Forensic Science in the United States: A Path Forward," was produced, emphasizing the need for research in the forensic disciplines, particularly those that rely on more subjective assessments. The committee also identified two important factors relevant to standards of evidence admissibility: the scientific methodology used and the impact of bias on the interpretation of data. In this article, I apply the NAS committee's findings to the field of forensic psychiatry, with specific recommendations to assist educators in achieving more objective assessment methodologies, critical in forensic education and the search for truth.

  15. Interacting fermions in rotation: chiral symmetry restoration, moment of inertia and thermodynamics

    NASA Astrophysics Data System (ADS)

    Chernodub, M. N.; Gongyo, Shinya

    2017-01-01

    We study rotating fermionic matter at finite temperature in the framework of the Nambu-Jona-Lasinio model. In order to respect causality the rigidly rotating system must be bound by a cylindrical boundary with appropriate boundary conditions that confine the fermions inside the cylinder. We show the finite geometry with the MIT boundary conditions affects strongly the phase structure of the model leading to three distinct regions characterized by explicitly broken (gapped), partially restored (nearly gapless) and spontaneously broken (gapped) phases at, respectively, small, moderate and large radius of the cylinder. The presence of the boundary leads to specific steplike irregularities of the chiral condensate as functions of coupling constant, temperature and angular frequency. These steplike features have the same nature as the Shubnikov-de Haas oscillations with the crucial difference that they occur in the absence of both external magnetic field and Fermi surface. At finite temperature the rotation leads to restoration of spontaneously broken chiral symmetry while the vacuum at zero temperature is insensitive to rotation ("cold vacuum cannot rotate"). As the temperature increases the critical angular frequency decreases and the transition becomes softer. A phase diagram in angular frequency-temperature plane is presented. We also show that at fixed temperature the fermion matter in the chirally restored (gapless) phase has a higher moment of inertia compared to the one in the chirally broken (gapped) phase.

  16. Estimating transport coefficients in hot and dense quark matter

    NASA Astrophysics Data System (ADS)

    Deb, Paramita; Kadam, Guru Prakash; Mishra, Hiranmaya

    2016-11-01

    We compute the transport coefficients, namely, the coefficients of shear and bulk viscosity, as well as thermal conductivity, for hot and dense quark matter. The calculations are performed within the Nambu-Jona-Lasinio (NJL) model. The estimation of the transport coefficients is made using a quasiparticle approach of solving the Boltzmann kinetic equation within the relaxation time approximation. The transition rates are calculated in a manifestly covariant manner to estimate the thermal-averaged cross sections for quark-quark and quark-antiquark scattering. The calculations are performed for finite chemical potential also. Within the parameters of the model, the ratio of shear viscosity to entropy density has a minimum at the Mott transition temperature. At vanishing chemical potential, the ratio of bulk viscosity to entropy density, on the other hand, decreases with temperature, with a sharp decrease near the critical temperature, and vanishes beyond it. At finite chemical potential, however, it increases slowly with temperature beyond the Mott temperature. The coefficient of thermal conductivity also shows a minimum at the critical temperature.

  17. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    SciTech Connect

    Azaria, P.; Konik, R. M.; Lecheminant, P.; Pálmai, T.; Takács, G.; Tsvelik, A. M.

    2016-08-03

    In our paper we study a (1+1)-dimensional version of the famous Nambu–Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ, is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ=0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phases with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). Finally, the QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).

  18. The Use of Elasto-Visco-Plastic Material Model Coupled with Pressure-Volume Thermodynamic Relationship to Simulate the Stretch Blow Molding of Polyethylene Terephthalate

    NASA Astrophysics Data System (ADS)

    Mir, H.; Benrabah, Z.; Thibault, F.

    2007-05-01

    The use of polyethylene terephthalate (PET) in the stretch blow molding process presents several challenging issues due to various processing parameters and complex behavior of the material, which is both temperature and strain-rate dependent. In this paper, we generalize the G'Sell-Jonas law in 3D to model and simulate the elasto-visco-plastic (EVP) behavior of PET, taking into account strain-hardening and strain-softening. It is observed that the internal pressure (inside the preform) is significantly different from the nominal pressure (imposed in the blowing device upstream) since the internal pressure and the enclosed volume of the preform are fully coupled. In order to accurately simulate this phenomenon, a thermodynamic model was used to characterize the pressure-volume relationship (PVR). The predicted pressure evolution is thus more realistic when imposing only the machine power of the blowing device (air compressor or vacuum pump). Mechanical and temperature equilibrium equations are fully nonlinear and solved separately with implicit schemes on the current deformed configuration, which is updated at each time step. Biaxial characterization tests were used to determine the model parameters in order to simulate the stretch blow molding process using the pressure-volume thermodynamic relationship. To validate this model, thickness predictions for three industrial cases will be presented and compared to experimental measurements.

  19. Hybrid Stars in the Framework of NJL Models

    NASA Astrophysics Data System (ADS)

    Contrera, Gustavo A.; Orsaria, Milva; Ranea-Sandoval, I. F.; Weber, Fridolin

    We compute models for the equation of state (EoS) of the matter in the cores of hybrid stars. Hadronic matter is treated in the non-linear relativistic mean-field approximation, and quark matter is modeled by three-flavor local and non-local Nambu‑Jona-Lasinio (NJL) models with repulsive vector interactions. The transition from hadronic to quark matter is constructed by considering either a soft phase transition (Gibbs construction) or a sharp phase transition (Maxwell construction). We find that high-mass neutron stars with masses up to 2.1 ‑ 2.4M⊙ may contain a mixed phase with hadrons and quarks in their cores, if global charge conservation is imposed via the Gibbs conditions. However, if the Maxwell conditions is considered, the appearance of a pure quark matter core either destabilizes the star immediately (commonly for non-local NJL models) or leads to a very short hybrid star branch in the mass-radius relation (generally for local NJL models).

  20. Quark Model Estimate of ω NN and ρ NN Coupling Constants.

    NASA Astrophysics Data System (ADS)

    Qian, L.; Banerjee, S.; Tandy, P. C.

    1996-10-01

    Approximate Bethe-Salpeter solutions for ρ and ω mesons are used to estimate the vector and tensor coupling constants for these mesons with the nucleon. The meson-quark amplitudes are coupled to the valence quarks of a mean field chiral quark-meson model of the nucleon. The meson description used here is based upon a finite range barqq interaction which in turn is constrained only by pion physics. The vector meson properties here are therefore predictions. In this respect, and others, the present results are compared to recent estimates(S.-F. Gao, L.S. Celenza, C.M. Shakin, W.-D. Sun and J. Szweda, Phys. Rev. C53), 1936 (1996). of vector meson coupling constants based upon the zero-range Nambu-Jona-Lasinio (NJL) model. In particular, we find a ratio f_ρ / g_ρ agreeing better with the empirical value than with the vector meson dominance value inherent in the NJL model. The absolute values of the vector coupling constants are found to be very similar to the empirical values; the magnitudes of the meson barqq substructure amplitudes are crucial to this result.

  1. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    DOE PAGES

    Azaria, P.; Konik, R. M.; Lecheminant, P.; ...

    2016-08-03

    In our paper we study a (1+1)-dimensional version of the famous Nambu–Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ, is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ=0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phasesmore » with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). Finally, the QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).« less

  2. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    SciTech Connect

    Azaria, P.; Konik, R. M.; Lecheminant, P.; Pálmai, T.; Takács, G.; Tsvelik, A. M.

    2016-08-03

    In our paper we study a (1+1)-dimensional version of the famous Nambu–Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ, is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ=0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phases with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). Finally, the QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).

  3. Flavor dependence of the pion and kaon form factors and parton distribution functions

    DOE PAGES

    Hutauruk, Parada T. P.; Cloët, Ian C.; Thomas, Anthony W.

    2016-09-01

    The separate quark flavor contributions to the pion and kaon valence quark distribution functions are studied, along with the corresponding electromagnetic form factors in the space-like region. The calculations are made using the solution of the Bethe-Salpeter equation for the model of Nambu and Jona-Lasinio with proper-time regularization. Both the pion and kaon form factors and the valence quark distribution functions reproduce many features of the available empirical data. The larger mass of the strange quark naturally explains the empirical fact that the ratio u(K) + (x)/u(pi) + (x) drops below unity at large x, with a value of approximately Mmore » $$2\\atop{u}$$/Ms$$2\\atop{s}$$ as x → 1. With regard to the elastic form factors we report a large flavor dependence, with the u-quark contribution to the kaon form factor being an order of magnitude smaller than that of the s-quark at large Q2, which may be a sensitive measure of confinement effects in QCD. Surprisingly though, the total K+ and π+ form factors differ by only 10%. Lastly, in general we find that flavor breaking effects are typically around 20%.« less

  4. Flavor dependence of the pion and kaon form factors and parton distribution functions

    SciTech Connect

    Hutauruk, Parada T. P.; Cloët, Ian C.; Thomas, Anthony W.

    2016-09-01

    The separate quark flavor contributions to the pion and kaon valence quark distribution functions are studied, along with the corresponding electromagnetic form factors in the space-like region. The calculations are made using the solution of the Bethe-Salpeter equation for the model of Nambu and Jona-Lasinio with proper-time regularization. Both the pion and kaon form factors and the valence quark distribution functions reproduce many features of the available empirical data. The larger mass of the strange quark naturally explains the empirical fact that the ratio u(K) + (x)/u(pi) + (x) drops below unity at large x, with a value of approximately M$2\\atop{u}$/Ms$2\\atop{s}$ as x → 1. With regard to the elastic form factors we report a large flavor dependence, with the u-quark contribution to the kaon form factor being an order of magnitude smaller than that of the s-quark at large Q2, which may be a sensitive measure of confinement effects in QCD. Surprisingly though, the total K+ and π+ form factors differ by only 10%. Lastly, in general we find that flavor breaking effects are typically around 20%.

  5. Prospective Technology Assessment of Synthetic Biology: Fundamental and Propaedeutic Reflections in Order to Enable an Early Assessment.

    PubMed

    Schmidt, Jan Cornelius

    2016-08-01

    Synthetic biology is regarded as one of the key technosciences of the future. The goal of this paper is to present some fundamental considerations to enable procedures of a technology assessment (TA) of synthetic biology. To accomplish such an early "upstream" assessment of a not yet fully developed technology, a special type of TA will be considered: Prospective TA (ProTA). At the center of ProTA are the analysis and the framing of "synthetic biology," including a characterization and assessment of the technological core. The thesis is that if there is any differentia specifica giving substance to the umbrella term "synthetic biology," it is the idea of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called "late-modern technology." -I start this paper by analyzing the three most common visions of synthetic biology. Then I argue that one particular vision deserves more attention because it underlies the others: the vision of self-organization. I discuss the inherent limits of this new type of late-modern technology in the attempt to control and monitor possible risk issues. I refer to Hans Jonas' ethics and his early anticipation of the risks of a novel type of technology. I end by drawing conclusions for the approach of ProTA towards an early societal shaping of synthetic biology.

  6. The Chiral Quark Soliton Model for the Nucleon

    NASA Astrophysics Data System (ADS)

    Watabe, T.; Toki, H.

    1992-03-01

    We study the chiral invariant quark model lagrangians under the Hartree approximation for construction of a hedgehog solution with the baryon number B = 1. We take into account the Dirac sea contributions to the energy and various densities in terms of the heat-kernel method. With the parameters of the Nambu-Jona-Lasinio model lagrangian fixed by the meson properties, we do not find any B = 1 hedgehog solutions except for one case, even which is, however, unstable against small perturbation. We study then the Diakonov-Petrov model lagrangian, which is introduced by investigating the properties of the quark field in the instanton background in QCD. We find in this case stable hedgehog solutions under the heat-kernel regularization method in some parameter region. We study also the isoscalar-vector type (omega-meson type) correlations among quarks for the nucleon properties. The hedgehog energy, the baryon root mean square radius and the axial vector coupling constant g_{A} are calculated as a function of the omega-quark coupling strength.

  7. "A different kind of beauty": scientific and architectural style in I.M. Pei's Mesa Laboratory and Louis Kahn's Salk Institute.

    PubMed

    Leslie, Stuart W

    2008-01-01

    I.M. Pei's Mesa Laboratory for the National Center for Atmospheric Research in Boulder, Colorado, and Louis Kahn's Salk Institute in La Jolla, California, are rare examples of laboratories as celebrated for their architecture as for their scientific contributions. Completed in the mid-1960s, these signature buildings still express the scientific style of their founding directors, Walter Roberts and Jonas Salk. yet in commissioning their laboratories, Roberts and Salk had to work with architects as strong-willed as themselves. A close reading of the two laboratories reveals the ongoing negotiations and tensions in collaborations between visionary scientist and visionary architect. Moreover, Roberts and Salk also had to become architects of atmospheric and biomedical sciences. For laboratory architecture, however flexible in theory, necessarily stabilizes scientific practice, since a philosophy of research is embedded in the very structure of the building and persists far longer than the initial vision and mission that gave it life. Roberts and Salk's experiences suggest that even the most carefully designed laboratories must successfully adapt to new disciplinary configurations, funding opportunities, and research priorities, or risk becoming mere architectural icons.

  8. [Inactivated poliovirus vaccines: an inevitable choice for eliminating poliomyelitis].

    PubMed

    Vidor, J D; Jean-Denis, Shu

    2016-12-06

    The inactivated poliovirus vaccine (IPV) is a very old tool in the fight against poliomyelitis. Though supplanted by oral poliovirus vaccine (OPV) in the 1960s and 1970s, the IPV has now become an inevitable choice because of the increasingly recognized risks associated with continuous use of OPVs. Following the pioneering work of Jonas Salk, who established key principles for the IPV, considerable experience has accumulated over the years. This work has led to modern Salk IPV-containing vaccines, based on the use of inactivated wildtype polioviruses, which have been deployed for routine use in many countries. Very good protection against paralysis is achieved with IPV through the presence of circulating antibodies able to neutralize virus infectivity toward motor neurons. In addition, with IPV, a variable degree of protection against mucosal infection (and therefore transmission) through mucosal antibodies and immune cells is achieved, depending on previous exposure of subjects to wildtype or vaccine polioviruses. The use of an IPV-followed-by-OPV sequential immunization schedule has the potential advantage of eliminating the vaccine-associated paralytic poliomyelitis (VAPP) risk, while limiting the risks of vaccine-derived poliovirus (VDPVs). Sabin strain-derived IPVs are new tools, only recently beginning to be deployed, and data are being generated to document their performance. IPVs will play an irreplaceable role in global eradication of polio.

  9. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    NASA Astrophysics Data System (ADS)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2016-06-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates ( 10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass ( α ) transition and the secondary ( β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  10. Rippled Surface Structure and Electronic and Magnetic Properties of Ni_3Al(001)

    NASA Astrophysics Data System (ADS)

    Lee, Jae Il; Hong, S. C.; Mannstadt, W.; Freeman, A. J.

    1998-03-01

    LEED experiments on the composite Ni-Al surface of Ni_3Al(001) revealed a very small amount of ripplingfootnote D. Sondericker, F. Jona and P. M. Marcus, Phys. Rev. B33, 900 (1986). Challenged by this observation, structural, electronic and magnetic properties of Ni_3Al(001) were investigated by the local density full-potential linearized augmented plane wave (FLAPW) methodfootnote E. Wimmer, H. Krakauer, M. Weinert and A. J. Freeman, Phys. Rev. B24, 864 (1981).. A stable rippled surface atomic geometry was determined by atomic force calculations, with both surface Ni and Al atoms contracting down to the bulk region-consistent with experiment. The amount of rippling found by calculation (0.054 Åis almost within the experimental error bar (0.02 ± 0.03 ÅCharge densities, calculated work functions, and density of states for the rippled surfaces are reported. The spin polarized calculation shows that the magnetic moments for the Ni atoms decrease from 0.2 μB for the center layer to ~ 0.03 μB for the surface layer, which is essentially "magnetically dead". * Work in Korea supported by KOSEF through SNU-CTP and work at Northwestern U. supported by ONR

  11. A Critical Assessment of Three Usual Equations for Strain Hardening and Dynamic Recovery

    NASA Astrophysics Data System (ADS)

    Montheillet, Frank; Piot, David; Matougui, Nedjoua; Fares, Mohamed Lamine

    2014-09-01

    The Laasraoui-Jonas (LJ), Kocks-Mecking (KM), and power law (PW) stress-strain equations pertaining to hot working of metals within the range of moderate strains ( i.e., before the occurrence of dynamic recrystallization) are compared. It is shown that it is not possible to select the "best" one to fit a given experimental flow curve, neither in the σ - ɛ nor in the diagram. Noting that each of the three laws depends on two constitutive parameters, transformation formulae are then derived allowing the parameters of one law to be derived from the parameters of any of the two others. The fit of a given LJ equation by a PW law is then discussed. Finally, the transformation formulae are used to estimate the current rate of dynamic recovery when the flow rule is known in the form a PW law. The above theoretical derivations are illustrated by the specific case of a Fe-C alloy in the ferritic phase domain. However, they suggest that the conclusions are widely applicable to hot working of metals and alloys.

  12. Flavor dependence of quasi Nambu-Goldstone fermion masses

    NASA Astrophysics Data System (ADS)

    Yasuè, Masaki; Terazawa, Hidezumi

    1987-10-01

    A possible flavor dependence of masses for light quasi Nambu-Goldstone fermions (QNGF's) is examined in a supersymmetric (SUSY) nonlinear-interaction model of the Nambu-Jona-Lasinio type with SO(2N, C)-->SO(n, C)×SO(2N-n, C) by ~Λ2, in which subquarks (Ai, ψi)a (a=1, 2; i=1, ..., 2N) belong to 2N. SUSY is broken by scalar mass terms, μi2Ai(a)2and μi2Ai(1)Ai(2) (μi, μi <<Λ). The masses of the QNGF's, MQNGF, are controlled by MiSS2=μi2+cμi2: MQNGF=mF+fMiSS2+gMjSS with mF=O(MSS2/Λ), f, g=O(Λ-1) and c=O(1) for i in SO(n) and j in SO(2N-n). A large mass splitting between QNGF's and (pseudo Nambu-Goldstone bosons ((P)NGB's): MQNGF/M(P)NGB = O(MSS/Λ) << 1 is shown to arise.

  13. Vaccine hesitancy: parental, professional and public responsibility.

    PubMed

    Di Pietro, Maria Luisa; Poscia, Andrea; Teleman, Adele Anna; Maged, Davide; Ricciardi, Walter

    2017-01-01

    The opposition to vaccinations is a well-known phenomenon that dates back to the Victorian age when it was self-limited by the awareness of the importance to be protected against fearsome infectious diseases. In the XX century, the mass use of vaccination has - instead - consented to eradicate or drastically reduce the burden of diseases such as smallpox and polio. These positive effects of the vaccination campaigns have blurred out, if not erased, the memory of the tragic consequences of the past's widespread diseases, leading people to underestimate the severity of the harm that vaccinations prevent. In recent years, a complex mixture of contextual factors have promoted an amplification of that paradoxical situation, leading experts to study causes and consequences of the so called "vaccine hesitancy". Several studies have shown the impact for children and for the community of the refusal or hesitation towards vaccinations from different points of view, including epidemiological, clinical, social and economic evaluation. This article provides an analysis of vaccine hesitancy from an ethical perspective: parental, professional and public responsibilities are analysed and described according to the "responsibility of the fathers towards the children", as articulated by Hans Jonas in 1979.

  14. HIV-1 Immunogen: an overview of almost 30 years of clinical testing of a candidate therapeutic vaccine.

    PubMed

    Graziani, Gina M; Angel, Jonathan B

    2016-07-01

    Although current antiretroviral therapy (ART) has transformed HIV infection into a chronic, manageable disease, ART does not cure HIV infection. Furthermore, the majority of the world's infected individuals live in resource-limited countries in which access to ART is limited. Thus, the development of an effective therapeutic HIV vaccine would be an invaluable treatment alternative. Developed by the late Dr. Jonas Salk, HIV-1 Immunogen (Remune®) is a candidate therapeutic vaccine that has been studied in thousands of HIV-infected individuals in more than a dozen clinical trials during almost three decades. This Drug Evaluation, which summarizes the results of these trials that have shown the vaccine to be safe and immunogenic, also discusses the contradictory and controversial conclusions drawn from the phases 2, 2/3 and 3 trials that assessed the clinical efficacy of this vaccine. Given the lack of unequivocal clinical benefits of HIV-1 Immunogen despite almost 30 years of extensive testing, it does not appear, in our view, that this vaccine is a clinically effective immunotherapy. However, inclusion of this vaccine in the newly proposed 'Kick/Shock and Kill' strategy for HIV eradication, or use as a prophylactic vaccine, could be considered for future trials.

  15. Renormalization group flows in a Lifshitz-like four-Fermi model

    SciTech Connect

    Dhar, Avinash; Mandal, Gautam; Nag, Partha

    2010-04-15

    We study renormalization group flows in the Lifshitz-like N-flavor four-Fermi model discussed in [Phys. Rev. D 80, 105018 (2009)]. In the large-N limit, a nontrivial flow occurs in only one of all possible marginal couplings and one relevant coupling, which provides the scale for Lorentz invariance violations. We discuss in detail the phase diagram and renormalization group flows in the space of couplings, which includes the Lifshitz fixed point, the free field fixed point and a new fixed point characterized by z=1 scaling and a violation of Lorentz invariance, which cannot be tuned away by adjusting a parameter. In the broken symmetry phase, the model flows from the z=3 Lifshitz-like fixed point in the ultraviolet to this new fixed point in the infrared. However, in a modified version of the present model, which has an effective ultraviolet cutoff much smaller than the Lorentz invariance violating scale, the infrared behavior is governed by an approximately Lorentz invariant theory, similar to the low-energy limit of the usual relativistic Nambu-Jona-Lasinio model. Such a modified model could be realized by a supersymmetric version of the present model, if it exists.

  16. Bulk viscosity of two-flavor quark matter from the Kubo formalism

    NASA Astrophysics Data System (ADS)

    Harutyunyan, Arus; Sedrakian, Armen

    2017-08-01

    We study the bulk viscosity of quark matter in the strong coupling regime within the two-flavor Nambu-Jona-Lasinio model. The dispersive effects that lead to nonzero bulk viscosity arise from quark-meson fluctuations above the Mott transition temperature, where meson decay into two quarks is kinematically allowed. We adopt the Kubo-Zubarev formalism and compute the equilibrium imaginary-time correlation function for pressure in the O (1 /Nc) power counting scheme. The bulk viscosity of matter is expressed in terms of the Lorentz components of the quark spectral function and includes multiloop contributions which arise via resummation of infinite geometrical series of loop diagrams. We show that the multiloop contributions dominate the single-loop contribution close to the Mott line, whereas at high temperatures the one-loop contribution is dominant. The multiloop bulk viscosity dominates the shear viscosity close to the Mott temperature by factors 5 to 20, but, with increasing temperature, the shear viscosity becomes the dominant dissipation mechanism of stresses as the one-loop contribution becomes the main source of bulk viscosity.

  17. A cellular automaton model for microstructural simulation of friction stir welded AZ91 magnesium alloy

    NASA Astrophysics Data System (ADS)

    Akbari, Mostafa; Asadi, Parviz; Besharati Givi, MohammadKazem; Zolghadr, Parisa

    2016-03-01

    To predict the grain size and microstructure evolution during friction stir welding (FSW) of AZ91 magnesium alloy, a finite element model (FEM) is developed based on the combination of a cellular automaton model and the Kocks  -  Mecking and Laasraoui-Jonas models. First, according to the flow stress curves and using the Kocks  -  Mecking model, the hardening and recovery parameters and the strain rate sensitivity were calculated. Next, an FEM model was established in Deform-3D software to simulate the FSW of AZ91 magnesium alloy. The results of the FEM model are used in microstructure evolution models to predict the grain size and microstructure of the weld zone. There is a good agreement between the simulated and experimental microstructures, and the proposed model can simulate the dynamic recrystallization (DRX) process during FSW of AZ91 alloy. Moreover, microstructural properties of different points in the SZ as well as the effect of the w/v parameter on the grain size and microstructure are considered.

  18. Achieving an HIV vaccine: the need for an accelerated national campaign.

    PubMed

    Marlink, R

    1997-11-01

    The development of an effective HIV vaccine has become a crucial national healthcare goal. To develop a worldwide AIDS vaccine, an international collaboration with developing countries is needed. The global approach rationale is threefold: millions of lives can be saved, a vaccine preparation can be tested more rapidly and economically among populations with high rates of infections; and the HIV epidemic comprises at least ten different subtypes. Although a number of barriers to the successful development of an HIV vaccine exist, the polio vaccine can be used as an example to show researchers how to overcome the obstacles. Jonas Salk, the polio vaccine developer, used killed whole virus in a technique that critics argued would not be fully effective. However, the Salk vaccine reduced polio-related paralysis by 72 percent, while the more effective Sabin oral vaccine did not become available until several years later. The lesson to be learned is that any percent of effectiveness is better than nothing, and researchers should not abandon uncertain HIV vaccine development efforts because they believe a better solution may develop in the future. The existence of traditional research should not preclude the development of new solutions that might prove more effective. For example, in the case of polio, the March of Dimes campaign pushed both the Salk and Sabin vaccines despite the skepticism of many academic research groups.

  19. Rebuilding immunity with Remune.

    PubMed

    Whitfield, L

    1998-01-01

    Remune, an immune response therapy composed of inactivated HIV, is designed to enhance the immune system's ability to recognize and kill HIV proteins. Developed by Dr. Jonas Salk, researchers hope Remune's actions can alter the course of HIV infection and slow disease progression. Remune has gained Food and Drug Administration (FDA) approval to enter the critical Phase III trial stage. Two clinical trials are tracking Remune's immunogenicity (ability to provoke an immune response), its immunogenicity relative to dose level, and its effect on viral load. An ongoing trial, approved in February of 1996, enrolled 2,500 patients at 74 sites. The manufacturer, Immune Response Corporation (IRC), announced earlier this year that treatment with Remune induces an immune response to HIV that cross-reacts with different strains of the virus. This immune response is crucial for developing an effective worldwide treatment. Remune decreases levels of tumor necrosis factor alpha (TNF-a). IRC recently began a Phase I clinical trial in Great Britain that combines Remune with a protease inhibitor, two antiviral nucleoside analogues, and Interleukin-2. The trial is designed to determine the role that the drug may play in restoring immune response.

  20. Vaccines today, vaccines tomorrow: a perspective.

    PubMed

    Loucq, Christian

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles Mérieux are known among experts only despite their contribution to global health. Thanks to a vaccine, smallpox has been eradicated, polio has nearly disappeared, Haemophilus influenzae B, measles and more recently meningitis A are controlled in many countries. While a malaria vaccine is undergoing phase 3, International Vaccine Institute, in collaboration with an Indian manufacturer has brought an oral inactivated cholera vaccine to pre-qualification. The field of vaccinology has undergone major changes thanks to philanthropists such as Bill and Melinda Gates, initiatives like the Decade of Vaccines and public private partnerships. Current researches on vaccines have more challenging targets like the dengue viruses, malaria, human immunodeficiency virus, the respiratory syncytial virus and nosocomial diseases. Exciting research is taking place on new adjuvants, nanoparticles, virus like particles and new route of administration. An overcrowded infant immunization program, anti-vaccine groups, immunizing a growing number of elderlies and delivering vaccines to difficult places are among challenges faced by vaccinologists and global health experts.

  1. Meeting report VLPNPV: Sessions 1 and 2: Plenary.

    PubMed

    Sainsbury, Frank

    2014-01-01

    Following the highly successful inaugural meeting in 2012, the second installment of Virus-Like Particles and Nano-Particle Vaccines (VLPNPV), proved to be a worthy follow-up in an outstanding conference series. VLPNPV is a forum for academics and industry to address one of the major areas of need in biomedical sciences, the development of novel prophylactic and therapeutic vaccines. The conference was opened by Professor Marianne Manchester of the University of California, San Diego who pointed to the significance of the site chosen for the conference, the Salk Institute. Founded by Jonas Salk, the Salk Institute for Biological Studies is a non-profit, independent research institute with focuses in molecular biology and genetics, neurosciences, and plant biology. This diversity in research themes reflects the wishes of the institute's founder who saw value in using interdisciplinary approaches to understanding the basic principles in life, aimed at generating new therapies and treatments for human disease. Likewise, interdisciplinarity was reflected in the main themes of the meeting, which also highlight some of the potential advantages of virus-like particle (VLP) and nanoparticle vaccines, including novel formulations/adjuvanting effects, structurally accurate/designed antigens, production systems and capacity, and tailoring the immune response. These themes were covered by the 2 plenary sessions that opened the conference and are described in this report.

  2. [The history of polio in Sweden - from infantile paralysis to polio vaccine].

    PubMed

    Axelsson, Per

    2004-01-01

    Although other epidemics declined due to improved hygiene and sanitation, legislation, and vaccination, polio epidemics appeared in Sweden in 1881 and at the turn of the 20th century the disease became and annual feature in the Swedish epidemiological pattern. Due to the vaccination starting in 1957 epidemics ceased to exist in Sweden around 1965. This article deals with the history polio epidemics in Sweden, 1880-1965 and gives a brief description of: the demographical influence of polio, how did the medical authorities investigate and try to combat it, and the different comprehensions of how polio affected its victims.A study of polio incidence in Sweden at the national level during 1905-1962 reveals that the disease caused major epidemics in 1911-1913 and 1953. At the beginning of the 20th century polio primarily attacked children up to 10 years of age, and at the end of the period victims were represented in all age groups, but mainly in the ages 20-39. Due to its enigmatic appearance, polio was not considered as an epidemic infectious disease during the 19th century. Sweden's early epidemics enabled Swedish medical science to act and together with American research institutes it acquired a leading role in international medical research on the disease. In the 1955 Jonas Salk produced the first successful vaccine against polio but also Sweden developed its own vaccine, different in choice of methods and materials from the widely used Salk-vaccine.

  3. [Piet de Somer, the University of Leuven and the Belgium poliovaccine in 1956-57].

    PubMed

    Billiau, A

    2011-01-01

    In the years following WW II, all 'Western' countries were struck by recurrent epidemics of infantile paralysis (poliomyelitis). In the early 1950s, a vaccine developed by Jonas Salk in Pittsburgh, became available in the U.S. and Canada. In 1953-54 central virology laboratories in Sweden, Denmark and France were already well advanced in setting up local production lines of the vaccine. At that point in time, the Catholic University of Leuven, on the initiative of the young microbiology professor, Piet De Somer, and in collaboration with the pharmaceutical concern R.I.T. (Recherches et Industries Thérapeutiques, Genval, Belgium), erected a new, multidisciplinary medical research institute, the Rega Institute. One of the research units to be headed by De Somer was destined to introduce the relatively new discipline of virology. As a test case, De Somer decided to venture on developing a production line of the Salk vaccine. In less than one year's time, the project was successful, such that Belgium became one of the first European countries to be self-supporting for its vaccine supply and to be able to initiate a large-scale vaccination campaign. The planning, preparation and execution of the project was accompanied by an extensive correspondence of De Somer with experts and other concerned parties in Belgium and abroad. This correspondence has been preserved and allows for a detailed reconstruction of the remarkable achievement.

  4. [AIDS: "We will win"].

    PubMed

    Chabrier, H

    1989-11-13

    An international colloquium on AIDS held near Paris from October 26-28, 1989, unlike the World Conference on AIDS in Montreal the year before, was able to find reasons for optimism. Significant progress was reported in immunotherapy and in chemotherapy. Successful experiments in vaccinating monkeys against the AIDS virus were reported from the US, France, and Zaire. Time is needed to prove the efficacy of the vaccines because of the slow development in AIDS. A vaccine is being tested by Jonas Salk and collaborators in 75 seropositive volunteers who do not yet show full blown disease but who have very low levels of T4 lymphocytes. Plans are underway for a larger test on 500 seropositive patients at different stages of infection. According to Salk, the new chemical and logical approach toward AIDS will allow combinations of immunotherapy and chemotherapy to destroy the virus. R. Gallo of France listed as accomplishments of the past year a better understanding of the virus, improved case management techniques, increased ability to control Kaposi's sarcoma, considerable progress in the search for a vaccine, and detection of immune proteins that affect the virus. New biological markers permit establishment of correlations between cellular modifications and the progress of the disease as well as the precise effects of treatment. The new immune system drugs immuthiol and DDI are expected to reach the market soon. Patients very soon will be able to receive less toxic alternative treatments, which can be combined for greater efficacy once their toxic interactions are understood.

  5. Vaccines today, vaccines tomorrow: a perspective

    PubMed Central

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles Mérieux are known among experts only despite their contribution to global health. Thanks to a vaccine, smallpox has been eradicated, polio has nearly disappeared, Haemophilus influenzae B, measles and more recently meningitis A are controlled in many countries. While a malaria vaccine is undergoing phase 3, International Vaccine Institute, in collaboration with an Indian manufacturer has brought an oral inactivated cholera vaccine to pre-qualification. The field of vaccinology has undergone major changes thanks to philanthropists such as Bill and Melinda Gates, initiatives like the Decade of Vaccines and public private partnerships. Current researches on vaccines have more challenging targets like the dengue viruses, malaria, human immunodeficiency virus, the respiratory syncytial virus and nosocomial diseases. Exciting research is taking place on new adjuvants, nanoparticles, virus like particles and new route of administration. An overcrowded infant immunization program, anti-vaccine groups, immunizing a growing number of elderlies and delivering vaccines to difficult places are among challenges faced by vaccinologists and global health experts. PMID:23596584

  6. Influence of pions on the hadron-quark phase transition

    SciTech Connect

    Lourenco, O.; Dutra, M.; Frederico, T.; Malheiro, M.; Delfino, A.

    2013-05-06

    In this work we present the features of the hadron-quark phase transition diagrams in which the pions are included in the system. To construct such diagrams we use two different models in the description of the hadronic and quark sectors. At the quark level, we consider two distinct parametrizations of the Polyakov-Nambu-Jona-Lasinio (PNJL) models. In the hadronic side, we use a well known relativistic mean-field (RMF) nonlinear Walecka model. We show that the effect of the pions on the hadron-quark phase diagrams is to move the critical end point (CEP) of the transitions lines. Such an effect also depends on the value of the critical temperature (T{sub 0}) in the pure gauge sector used to parametrize the PNJL models. Here we treat the phase transitions using two values for T{sub 0}, namely, T{sub 0}= 270 MeV and T{sub 0}= 190 MeV. The last value is used to reproduce lattice QCD data for the transition temperature at zero chemical potential.

  7. Quark Deconfinement in Rotating Neutron Stars

    NASA Astrophysics Data System (ADS)

    Mellinger, Richard; Weber, Fridolin; Spinella, William; Contrera, Gustavo; Orsaria, Milva

    2017-01-01

    In this paper, we use a three flavor non-local Nambu--Jona-Lasinio (NJL) model, an~improved effective model of Quantum Chromodynamics (QCD) at low energies, to investigate the existence of deconfined quarks in the cores of neutron stars. Particular emphasis is put on the possible existence of quark matter in the cores of rotating neutron stars (pulsars). In contrast to non-rotating neutron stars, whose particle compositions do not change with time (are frozen in), the type and structure of the matter in the cores of rotating neutron stars depends on the spin frequencies of these stars, which opens up a possible new window on the nature of matter deep in the cores of neutron stars. Our study shows that, depending on mass and rotational frequency, up to around 8% of the mass of a massive neutron star may be in the mixed quark-hadron phase, if the phase transition is treated as a Gibbs transition. We also find that the gravitational mass at which quark deconfinement occurs in rotating neutron stars varies quadratically with spin frequency, which can be fitted by a simple formula.

  8. QCD phase diagram at finite baryon and isospin chemical potentials

    SciTech Connect

    Sasaki, Takahiro; Sakai, Yuji; Yahiro, Masanobu; Kouno, Hiroaki

    2010-12-01

    The phase structure of two-flavor QCD is explored for thermal systems with finite baryon- and isospin-chemical potentials, {mu}{sub B} and {mu}{sub iso}, by using the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. The PNJL model with the scalar-type eight-quark interaction can reproduce lattice QCD data at not only {mu}{sub iso}={mu}{sub B}=0, but also {mu}{sub iso}>0 and {mu}{sub B}=0. In the {mu}{sub iso}-{mu}{sub B}-T space, where T is temperature, the critical endpoint of the chiral phase transition in the {mu}{sub B}-T plane at {mu}{sub iso}=0 moves to the tricritical point of the pion-superfluidity phase transition in the {mu}{sub iso}-T plane at {mu}{sub B}=0 as {mu}{sub iso} increases. The thermodynamics at small T is controlled by {radical}({sigma}{sup 2}+{pi}{sup 2}) defined by the chiral and pion condensates, {sigma} and {pi}.

  9. Isoscalar-vector interaction and hybrid quark core in massive neutron stars

    NASA Astrophysics Data System (ADS)

    Shao, G. Y.; Colonna, M.; Di Toro, M.; Liu, Y. X.; Liu, B.

    2013-05-01

    The hadron-quark phase transition in the core of massive neutron stars is studied with a newly constructed two-phase model. For nuclear matter, a nonlinear Walecka type model with general nucleon-meson and meson-meson couplings, recently calibrated by Steiner, Hemper and Fischer, is taken. For quark matter, a modified Polyakov-Nambu—Jona-Lasinio model, which gives consistent results with lattice QCD data, is used. Most importantly, we introduce an isoscalar-vector interaction in the description of quark matter, and we study its influence on the hadron-quark phase transition in the interior of massive neutron stars. With the constraints of neutron star observations, our calculation shows that the isoscalar-vector interaction between quarks is indispensable if massive hybrids star exist in the universe, and its strength determines the onset density of quark matter, as well as the mass-radius relations of hybrid stars. Furthermore, as a connection with heavy-ion-collision experiments we give some discussions about the strength of isoscalar-vector interaction and its effect on the signals of hadron-quark phase transition in heavy-ion collisions, in the energy range of the NICA at JINR-Dubna and FAIR at GSI-Darmstadt facilities.

  10. Equilibrium sequences of nonrotating and rapidly rotating crystalline color-superconducting hybrid stars

    NASA Astrophysics Data System (ADS)

    Ippolito, Nicola D.; Ruggieri, Marco; Rischke, Dirk H.; Sedrakian, Armen; Weber, Fridolin

    2008-01-01

    The three-flavor crystalline color-superconducting (CCS) phase of quantum chromodynamics (QCD) is a candidate phase for the ground state of cold matter at moderate densities above the density of the deconfinement phase transition. Apart from being a superfluid, the CCS phase has properties of a solid, such as a lattice structure and a shear modulus, and hence the ability to sustain multipolar deformations in gravitational equilibrium. We construct equilibrium configurations of hybrid stars composed of nuclear matter at low, and CCS quark matter at high, densities. Phase equilibrium between these phases is possible only for rather stiff equations of state of nuclear matter and large couplings in the effective Nambu—Jona-Lasinio Lagrangian describing the CCS state. We identify a new branch of stable CCS hybrid stars within a broad range of central densities which, depending on the details of the equations of state, either bifurcate from the nuclear sequence of stars when the central density exceeds that of the deconfinement phase transition or form a new family of configurations separated from the purely nuclear sequence by an instability region. The maximum masses of our nonrotating hybrid configurations are consistent with the presently available astronomical bounds. The sequences of hybrid configurations that rotate near the mass-shedding limit are found to be more compact and thus support substantially larger spins than their same mass nuclear counterparts.

  11. Dual use and the ethical responsibility of scientists.

    PubMed

    Ehni, Hans-Jörg

    2008-01-01

    The main normative problem in the context of dual use is to determine the ethical responsibility of scientists especially in the case of unintended, harmful, and criminal dual use of new technological applications of scientific results. This article starts from an analysis of the concepts of responsibility and complicity, examining alternative options regarding the responsibility of scientists. Within the context of the basic conflict between the freedom of science and the duty to avoid causing harm, two positions are discussed: moral skepticism and the ethics of responsibility by Hans Jonas. According to these reflections, four duties are suggested and evaluated: stopping research, systematically carrying out research for dual-use applications, informing public authorities, and not publishing results. In the conclusion it is argued that these duties should be considered as imperfect duties in a Kantian sense and that the individual scientist should be discharged as much as possible from obligations which follow from them by the scientific community and institutions created for this purpose.

  12. WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling.

    PubMed

    Shcherbina, Anna; Cooley, Jessica; Lutskiy, Maxim I; Benarafa, Charaf; Gilbert, Gary E; Remold-O'Donnell, Eileen

    2010-02-01

    The most consistent feature of Wiskott Aldrich syndrome (WAS) is profound thrombocytopenia with small platelets. The responsible gene encodes WAS protein (WASP), which functions in leucocytes as an actin filament nucleating agent -yet- actin filament nucleation proceeds normally in patient platelets regarding shape change, filopodia and lamellipodia generation. Because WASP localizes in the platelet membrane skeleton and is mobilized by alphaIIbbeta3 integrin outside-in signalling, we questioned whether its function might be linked to integrin. Agonist-induced alphaIIbbeta3 activation (PAC-1 binding) was normal for patient platelets, indicating normal integrin inside-out signalling. Inside-out signalling (fibrinogen, JON/A binding) was also normal for wasp-deficient murine platelets. However, adherence/spreading on immobilized fibrinogen was decreased for patient platelets and wasp-deficient murine platelets, indicating decreased integrin outside-in responses. Another integrin outside-in dependent response, fibrin clot retraction, involving contraction of the post-aggregation actin cytoskeleton, was also decreased for patient platelets and wasp-deficient murine platelets. Rebleeding from tail cuts was more frequent for wasp-deficient mice, suggesting decreased stabilisation of the primary platelet plug. In contrast, phosphatidylserine exposure, a pro-coagulant response, was enhanced for WASP-deficient patient and murine platelets. The collective results reveal a novel function for WASP in regulating pro-aggregatory and pro-coagulant responses downstream of integrin outside-in signalling.

  13. Collective modes in the color flavor-locked phase.

    SciTech Connect

    Anglani, R.; Mannarelli, M.; Ruggieri, M.

    2011-05-17

    We study the low-energy effective action for some collective modes of the color flavor-locked (CFL) phase of QCD. This phase of matter has long been known to be a superfluid because by picking a phase its order parameter breaks the quark-number U(1){sub B} symmetry spontaneously. We consider the modes describing fluctuations in the magnitude of the condensate, namely the Higgs mode, and in the phase of the condensate, namely the Nambu-Goldstone (NG) (or Anderson-Bogoliubov) mode associated with the breaking of U(1){sub B}. By employing as microscopic theory the Nambu-Jona-Lasinio model, we reproduce known results for the Lagrangian of the NG field to the leading order in the chemical potential and extend such results evaluating corrections due to the gap parameter. Moreover, we determine the interaction terms between the Higgs and the NG field. This study paves the way for a more reliable study of various dissipative processes in rotating compact stars with a quark matter core in the CFL phase.

  14. Dual condensates at finite isospin chemical potential

    NASA Astrophysics Data System (ADS)

    Zhang, Zhao; Miao, Qing

    2016-02-01

    The dual observables as order parameters for center symmetry are tested at finite isospin chemical potential μI in a Polyakov-loop enhanced chiral model of QCD with physical quark masses. As a counterpart of the dressed Polyakov-loop, the first Fourier moment of pion condensate is introduced for μI >mπ / 2 under the temporal twisted boundary conditions for quarks. We demonstrate that this dual condensate exhibits the similar temperature dependence as the conventional Polyakov-loop. We confirm that its rapid increase with T is driven by the evaporating of pion condensation. On the other hand, the dressed Polyakov-loop shows abnormal thermal behavior, which even decreases with T at low temperatures due to the influence of pion condensate. We also find that the dressed Polyakov-loop always rises most steeply at the chiral transition temperature, which is consistent with the previous results in Nambu-Jona-Lasinio (NJL) model and its variants without considering the center symmetry. Since both quantities are strongly affected by the chiral symmetry and pion condensation, we conclude that it is difficult to clarify the deconfinement transition from the dual condensates in this situation within this model.

  15. Transport coefficients of two-flavor quark matter from the Kubo formalism

    NASA Astrophysics Data System (ADS)

    Harutyunyan, Arus; Rischke, Dirk H.; Sedrakian, Armen

    2017-06-01

    The transport coefficients of quark matter at nonzero chemical potential and temperature are computed within the two-flavor Nambu-Jona-Lasinio model. We apply the Kubo formalism to obtain the thermal (κ ) and electrical (σ ) conductivities as well as an update of the shear viscosity (η ) by evaluating the corresponding equilibrium two-point correlation functions to leading order in the 1 /Nc expansion. The Dirac structure of the self-energies and spectral functions is taken into account as these are evaluated from the meson-exchange Fock diagrams for on-mass-shell quarks. We find that the thermal and electrical conductivities are decreasing functions of temperature and density above the Mott temperature TM of dissolution of mesons into quarks, the main contributions being generated by the temporal and vector components of the spectral functions. The coefficients show a universal dependence on the ratio T /TM for different densities, i.e., the results differ by a chemical-potential dependent constant. We also show that the Wiedemann-Franz law for the ratio σ /κ does not hold. The ratio η /s , where s is the entropy density, is of order of unity (or larger) close to the Mott temperature and, as the temperature increases, approaches the AdS /CFT bound 1 /4 π . It is also conjectured that the ratio κ T /cV, with cV being the specific heat, is bounded from below by 1 /18 .

  16. Chiral nucleon-Δ using the coherent-pion pair approximation

    NASA Astrophysics Data System (ADS)

    Sayed Aly, Tarek; McNeil, J. A.

    1996-10-01

    Despite significant strides in the numerical assault on QCD, this candidate theory of the strong interactions remains a computational challenge and models incorporating its important symmetries remain attractive alternatives for gaining insight into the nucleon problem. One such class of models which does not incorporate confinement but does respect chiral symmetry is the Nambu-Jona-Lasinio model and in particular its bosonized variant, the linear sigma model using quarks and mesonic degrees of freedom. About a decade ago several groups made significant progress in understanding fundamental nucleon properties using such models. In this work we re-visit one such effort undertaken by K. Goeke et al.(K. Goeke, M. Harvey, F. Grümmer, and J. N. Urbano, Phys. Rev. D37), 754 (1988). who computed nucleon and Δ properties using the so-called coherent pair approximation to treat the quantum nature of the pion field in a more realistic fashion. In rederiving their equations we have discovered some discrepancies in the treatment of the coherent pair Fock states. In this work we present alternative equations for the coherent-pair states. Numerical work to evaluate the new equations for the nucleon-Δ sector are underway.

  17. Toward a first-principle derivation of confinement and chiral-symmetry-breaking crossover transitions in QCD

    SciTech Connect

    Kondo, Kei-Ichi

    2010-09-15

    We give a theoretical framework to obtain a low-energy effective theory of quantum chromodynamics (QCD) towards a first-principle derivation of confinement/deconfinement and chiral-symmetry breaking/restoration crossover transitions. In fact, we demonstrate that an effective theory obtained using simple but nontrivial approximations within this framework enables us to treat both transitions simultaneously on equal footing. A resulting effective theory is regarded as a modified and improved version of nonlocal Polyakov-loop extended Nambu-Jona-Lasinio (nonlocal PNJL) models proposed recently by Hell, Roessner, Cristoforetti, and Weise, and Sasaki, Friman, and Redlich, extending the original (local) PNJL model by Fukushima and others. A novel feature is that the nonlocal NJL coupling depends explicitly on the temperature and Polyakov loop, which affects the entanglement between confinement and chiral-symmetry breaking, together with the cross term introduced through the covariant derivative in the quark sector considered in the conventional PNJL model. The chiral-symmetry breaking/restoration transition is controlled by the nonlocal NJL interaction, while the confinement/deconfinement transition in the pure gluon sector is specified by the nonperturbative effective potential for the Polyakov loop obtained recently by Braun, Gies, Marhauser, and Pawlowski. The basic ingredients are a reformulation of QCD based on new variables and the flow equation of the Wetterich type in the Wilsonian renormalization group. This framework can be applied to investigate the QCD phase diagram at finite temperature and density.

  18. Toward a first-principle derivation of confinement and chiral-symmetry-breaking crossover transitions in QCD

    NASA Astrophysics Data System (ADS)

    Kondo, Kei-Ichi

    2010-09-01

    We give a theoretical framework to obtain a low-energy effective theory of quantum chromodynamics (QCD) towards a first-principle derivation of confinement/deconfinement and chiral-symmetry breaking/restoration crossover transitions. In fact, we demonstrate that an effective theory obtained using simple but nontrivial approximations within this framework enables us to treat both transitions simultaneously on equal footing. A resulting effective theory is regarded as a modified and improved version of nonlocal Polyakov-loop extended Nambu-Jona-Lasinio (nonlocal PNJL) models proposed recently by Hell, Rössner, Cristoforetti, and Weise, and Sasaki, Friman, and Redlich, extending the original (local) PNJL model by Fukushima and others. A novel feature is that the nonlocal NJL coupling depends explicitly on the temperature and Polyakov loop, which affects the entanglement between confinement and chiral-symmetry breaking, together with the cross term introduced through the covariant derivative in the quark sector considered in the conventional PNJL model. The chiral-symmetry breaking/restoration transition is controlled by the nonlocal NJL interaction, while the confinement/deconfinement transition in the pure gluon sector is specified by the nonperturbative effective potential for the Polyakov loop obtained recently by Braun, Gies, Marhauser, and Pawlowski. The basic ingredients are a reformulation of QCD based on new variables and the flow equation of the Wetterich type in the Wilsonian renormalization group. This framework can be applied to investigate the QCD phase diagram at finite temperature and density.

  19. Confinement, quark mass functions, and spontaneous chiral symmetry breaking in Minkowski space

    SciTech Connect

    Biernat, Elmar P.; Gross, Franz L.; Pena, Teresa; Stadler, Alfred

    2014-01-01

    We formulate the covariant equations for quark-antiquark bound states in Minkowski space in the framework of the Covariant Spectator Theory. The quark propagators are dressed with the same kernel that describes the interaction between different quarks. We show that these equations are charge conjugation invariant, and that in the chiral limit of vanishing bare quark mass, a massless pseudoscalar bound state is produced in a Nambu--Jona-Lasinio (NJL) mechanism, which is associated with the Goldstone boson of spontaneous chiral symmetry breaking. In this introductory paper we test the formalism by using a simplified kernel consisting of a momentum-space $\\delta$-function with a vector Lorentz structure, to which one adds a mixed scalar and vector confining interaction. The scalar part of the confining interaction is not chirally invariant by itself, but decouples from the equations in the chiral limit and therefore allows the NJL mechanism to work. With this model we calculate the quark mass function, and we compare our Minkowski-space results to LQCD data obtained in Euclidean space. In a companion paper we apply this formalism to a calculation of the pion form factor.

  20. Probing the hadron-quark mixed phase at high isospin and baryon density. Sensitive observables

    NASA Astrophysics Data System (ADS)

    Di Toro, Massimo; Colonna, Maria; Greco, Vincenzo; Shao, Guo-Yun

    2016-08-01

    We discuss the isospin effect on the possible phase transition from hadronic to quark matter at high baryon density and finite temperatures. The two-Equation of State (Two-EoS) model is adopted to describe the hadron-quark phase transition in dense matter formed in heavy-ion collisions. For the hadron sector we use Relativistic Mean-Field (RMF) effective models, already tested on heavy-ion collision (HIC). For the quark phase we consider various effective models, the MIT-Bag static picture, the Nambu-Jona-Lasinio (NJL) approach with chiral dynamics and finally the NJL coupled to the Polyakov-loop field (PNJL), which includes both chiral and (de)confinement dynamics. The idea is to extract mixed phase properties which appear robust with respect to the model differences. In particular we focus on the phase transitions of isospin asymmetric matter, with two main results: i) an earlier transition to a mixed hadron-quark phase, at lower baryon density/chemical potential with respect to symmetric matter; ii) an "Isospin Distillation" to the quark component of the mixed phase, with predicted effects on the final hadron production. Possible observation signals are suggested to probe in heavy-ion collision experiments at intermediate energies, in the range of the NICA program.

  1. Hadron-quark phase transition in asymmetric matter with dynamical quark masses

    SciTech Connect

    Shao, G. Y.; Colonna, M.; Di Toro, M.; Greco, V.; Plumari, S.; Liu, B.; Liu, Y. X.

    2011-05-01

    The two-equation-of-state model is used to describe the hadron-quark phase transition in asymmetric matter formed at high density in heavy-ion collisions. For the quark phase, the three-flavor Nambu-Jona-Lasinio effective theory is used to investigate the influence of dynamical quark mass effects on the phase transition. At variance to the MIT-Bag results, with fixed-current quark masses, the main important effect of the chiral dynamics is the appearance of an end point for the coexistence zone. We show that a first-order hadron-quark phase transition may take place in the region T subset of (50-80) MeV and {rho}{sub B} subset of (2-4){rho}{sub 0}, which is possible to be probed in the new planned facilities, such as FAIR at GSI-Darmstadt and NICA at JINR-Dubna. From the isospin properties of the mixed phase, some possible signals are suggested. The importance of chiral symmetry and dynamical quark mass on the hadron-quark phase transition is stressed. The difficulty of an exact location of a critical end point comes from its appearance in a region of competition between chiral symmetry breaking and confinement, where our knowledge of effective QCD theories is still rather uncertain.

  2. Motivations and barriers to cervical cancer screening among HIV infected women in HIV care: a qualitative study.

    PubMed

    Bukirwa, Agnes; Mutyoba, Joan N; Mukasa, Barbara N; Karamagi, Yvonne; Odiit, Mary; Kawuma, Esther; Wanyenze, Rhoda K

    2015-10-12

    Cervical cancer is the second commonest cancer in women worldwide and the commonest cancer among women in Uganda. Annual cervical screening is recommended for women living with HIV for early detection of abnormal cervical changes, however uptake remains grossly limited. This study assessed factors associated with cervical screening uptake among HIV infected women at Mildmay Uganda where cervical screening using Visual inspection with acetic acid and iodine (VIA and VILI) was integrated into HIV care since July 2009. Eighteen (18) in-depth interviews with HIV infected women and 6 key informant interviews with health care providers were conducted in April 2013 to assess client, health care provider and facility-related factors that affect cervical screening uptake. In-depth interview respondents included six HIV infected women in each of the following categories; women who had never screened, those who had screened once and missed follow-up annual screening, and those who had fully adhered to the annual screening schedule. Data was analyzed using content analysis method. Motivations for cervical cancer screening included the need for comprehensive assessment, diagnosis, and management of all ailments to ensure good health, fear of consequences of cervical cancer, suspicion of being at risk and the desire to maintain a good relationship with health care workers. The following factors negatively impacted on uptake of cervical screening: Myths and misconceptions such as the belief that a woman's ovaries and uterus could be removed during screening, fear of pain associated with cervical screening, fear of undressing and the need for women to preserve their privacy, low perceived cervical cancer risk, shortage of health workers to routinely provide cervical cancer education and screening, and competing priorities for both provider and patient time. Major barriers to repeat screening included limited knowledge and appreciation of the need for repeat screening, and lack of

  3. Plateau and transpulmonary pressure with elevated intra-abdominal pressure or atelectasis.

    PubMed

    Kubiak, Brian D; Gatto, Louis A; Jimenez, Edgar J; Silva-Parra, Hugo; Snyder, Kathleen P; Vieau, Christopher J; Barba, Jorge; Nasseri-Nik, Niloofar; Falk, Jay L; Nieman, Gary F

    2010-03-01

    ARDSnet standards limit plateau pressure (Pplat) to reduce ventilator induced lung injury (VILI). Transpulmonary pressure (Ptp) [Pplat-pleural pressure (Ppl)], not Pplat, is the distending pressure of the lung. Lung distention can be affected by increased intra-abdominal pressure (IAP) and atelectasis. We hypothesized that the changes in distention caused by increases in IAP and atelectasis would be reflected by Ptp but independent of Pplat. In Yorkshire pigs, esophageal pressure (Pes) was measured with a balloon catheter as a surrogate for Ppl under two experimental conditions: (1) high IAP group (n=5), where IAP was elevated by CO2 insufflation in 5 mm Hg steps from 0 to 30 mm Hg; and (2) Atelectasis group (n=5), where a double lumen endotracheal tube allowed clamping and degassing of either lung by O2 absorption. Lung collapse was estimated by increases in pulmonary shunt fraction. High IAP: Sequential increments in IAP caused a linear increase in Pplat (r2=0.754, P<0.0001). Ptp did not increase (r2=0.014, P=0.404) with IAP due to the concomitant increase in Pes (r2=0.726, P<0.0001). Partial Lung Collapse: There was no significant difference in Pplat between the atelectatic (21.83+/-0.63 cm H2O) and inflated lung (22.06+/-0.61 cmH2O, P<0.05). Partial lung collapse caused a significant decrease in Pes (11.32+/-1.11 mm Hg) compared with inflation (15.89+/-0.72 mm Hg, P<0.05) resulting in a significant increase in Ptp (inflated=5.97+/-0.72 mm Hg; collapsed=10.55+/-1.53 mm Hg, P<0.05). Use of Pplat to set ventilation may under-ventilate patients with intra-abdominal hypertension and over-distend the lungs of patients with atelectasis. Thus, Ptp must be used to accurately set mechanical ventilation in the critically ill. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  4. Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome.

    PubMed

    Fanelli, Vito; Ranieri, Marco V; Mancebo, Jordi; Moerer, Onnen; Quintel, Michael; Morley, Scott; Moran, Indalecio; Parrilla, Francisco; Costamagna, Andrea; Gaudiosi, Marco; Combes, Alain

    2016-02-10

    Mechanical ventilation with a tidal volume (VT) of 6 mL/kg/predicted body weight (PBW), to maintain plateau pressure (Pplat) lower than 30 cmH2O, does not completely avoid the risk of ventilator induced lung injury (VILI). The aim of this study was to evaluate safety and feasibility of a ventilation strategy consisting of very low VT combined with extracorporeal carbon dioxide removal (ECCO2R). In fifteen patients with moderate ARDS, VT was reduced from baseline to 4 mL/kg PBW while PEEP was increased to target a plateau pressure--(Pplat) between 23 and 25 cmH2O. Low-flow ECCO2R was initiated when respiratory acidosis developed (pH < 7.25, PaCO2 > 60 mmHg). Ventilation parameters (VT, respiratory rate, PEEP), respiratory compliance (CRS), driving pressure (DeltaP = VT/CRS), arterial blood gases, and ECCO2R system operational characteristics were collected during the period of ultra-protective ventilation. Patients were weaned from ECCO2R when PaO2/FiO2 was higher than 200 and could tolerate conventional ventilation settings. Complications, mortality at day 28, need for prone positioning and extracorporeal membrane oxygenation, and data on weaning from both MV and ECCO2R were also collected. During the 2 h run in phase, VT reduction from baseline (6.2 mL/kg PBW) to approximately 4 mL/kg PBW caused respiratory acidosis (pH < 7.25) in all fifteen patients. At steady state, ECCO2R with an average blood flow of 435 mL/min and sweep gas flow of 10 L/min was effective at correcting pH and PaCO2 to within 10 % of baseline values. PEEP values tended to increase at VT of 4 mL/kg from 12.2 to 14.5 cmH2O, but this change was not statistically significant. Driving pressure was significantly reduced during the first two days compared to baseline (from 13.9 to 11.6 cmH2O; p < 0.05) and there were no significant differences in the values of respiratory system compliance. Rescue therapies for life threatening hypoxemia such as prone position and ECMO were necessary in four and two

  5. [Cost-effectiveness analysis on the once-in-a-lifetime cervical cancer screening program for women living in rural and urban areas of China].

    PubMed

    Xu, He; Zhao, Fang-hui; Gao, Xiao-hong; Hu, Shang-ying; Chen, Jun-feng; Liu, Zhi-hua; Xu, Xiao-ling; Gao, Li-min; Liu, Qi-gui; Ma, Li; Liu, Yi-jun; Qiao, You-lin

    2013-04-01

    To estimate the cost-effectiveness of once-in-a-lifetime cervical cancer screening program and to predict the optimal modality for its operation on women living in rural and urban areas of China, based on Markov modeling and simulation. Three modalities including visual inspection with acetic acid plus Lugol's iodine (VIA/VILI), conventional Pap Smear (Pap Smear), and simple HPV DNA testing (careHPV) were hypothesized for the rural cohort, whereas other five modalities including Pap Smear, liquid-based cytology (LBC), simple HPV DNA testing (careHPV), Hybrid Capture 2 HPV DNA testing (HC2), and LBC plus HC2 (LBC + HC2) were tested for the urban cohort. A Markov model was constructed based on the factors as natural history, screening, diagnosis and treatment on cervical cancer using data related to the epidemics and the costs from rural and urban areas of the country. Long-term effectiveness and cost-effectiveness were predicted through simulation of the model. Compared to the non-screening scenario, the amount of life years saved were 277.97 - 2727.53 and 134.02 - 1446.84 years per 100 000 women, respectively, for different cohorts in rural and urban areas. The cost-effectiveness ratios were 1520.99 - 2453.74 and 3847.35 - 44 570.35 RMB per life year saved, respectively, for different cohorts in rural and urban areas. The incremental cost-effective ratio for careHPV starting from 40 years old (careHPV@40) and careHPV from 30 years old (careHPV@30) dominated other strategies for the rural cohort, while careHPV@40, careHPV@30, HC2 from 30 years old (HC2@30), and LBC + HC2 from 30 years old (LBC + HC2@30) were dominant for the urban cohort. All eight once-in-a-lifetime cervical cancer screening modalities were cost-effective based on our model. In particular, careHPV screening starting from 40 years old seemed to be the most cost-effective one for women living in both rural and urban areas.

  6. Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression

    PubMed Central

    Romas, Laura; Birse, Kenzie; Mayer, Kenneth H.; Abou, Max; Westmacott, Garrett; Giguere, Rebecca; Febo, Irma; Cranston, Ross D.; Carballo-Diéguez, Alex; McGowan, Ian

    2016-01-01

    Abstract Rectal use of a 1% tenofovir (TFV) gel is currently being evaluated for HIV prevention. While careful assessment of mucosal safety of candidate microbicides is a primary concern, tools to assess mucosal toxicity are limited. Mass spectrometry-based proteomics is a sensitive and high-throughput technique that can provide in-depth information on inflammation processes in biological systems. In this study, we utilized a proteomics approach to characterize mucosal responses in study participants involved in a phase 1 clinical trial of a rectal TFV-based gel. Project Gel was a phase 1 randomized (1:1), double-blind, multisite, placebo-controlled trial in which 24 participants received rectal TFV or a universal placebo [hydroxyethyl cellulose (HEC)] over a course of 8 daily doses. Rectal mucosal swabs were collected after 0, 1, and 8 doses and were analyzed by label-free tandem mass spectrometry. Differential protein expression was evaluated using a combination of paired (time-effects) and unpaired (across study arm) t-tests, and multivariate [least absolute shrinkage and selection operator (LASSO)] modeling. Within the TFV arm, 7% (17/249, p < .05) and 10% (25/249, p < .05) of total proteins changed after 1 and 8 daily applications of TFV gel, respectively, compared to 3% (7/249, p < .05) and 6% (16/249, p < .05) in the HEC arm. Biofunctional analysis associated TFV use with a decrease in epidermal barrier proteins (adj. p = 1.21 × 10−10). Multivariate modeling identified 13 proteins that confidently separated TFV gel users (100% calibration and 96% cross-validation accuracy), including the epithelial integrity factors (FLMNB, CRNN, CALM), serpins (SPB13, SPB5), and cytoskeletal proteins (VILI, VIME, WRD1). This study suggested that daily rectal applications of a 1% TFV gel may be associated with mucosal proteome changes involving epidermal development. Further assessment of more extended use of TFV-gel is recommended to validate

  7. On the Nambu fermion-boson relations for superfluid 3He

    NASA Astrophysics Data System (ADS)

    Sauls, J. A.; Mizushima, Takeshi

    2017-03-01

    Superfluid 3He is a spin-triplet (S =1 ), p -wave (L =1 ) BCS condensate of Cooper pairs with total angular momentum J =0 in the ground state. In addition to the breaking of U(1) gauge symmetry, separate spin or orbital rotation symmetry is broken to the maximal subgroup SO (3) S×SO (3) L→SO(3 ) J . The fermions acquire mass mF≡Δ , where Δ is the BCS gap. There are also 18 bosonic excitations: 4 Nambu-Goldstone modes and 14 massive amplitude Higgs modes. The bosonic modes are labeled by the total angular momentum J ∈{0 ,1 ,2 } , and parity under particle-hole symmetry c =±1 . For each pair of angular momentum quantum numbers J ,Jz , there are two bosonic partners with c =±1 . Based on this spectrum, Nambu proposed a sum rule connecting the fermion and boson masses for BCS-type theories, which for 3He-B is MJ,+ 2+MJ,- 2=4 mF2 for each family of bosonic modes labeled by J , where MJ ,c is the mass of the bosonic mode with quantum numbers (J ,c ) . The Nambu sum rule (NSR) has recently been discussed in the context of Nambu-Jona-Lasinio models for physics beyond the standard model to speculate on possible partners to the recently discovered Higgs boson at higher energies. Here, we point out that the Nambu fermion-boson mass relations are not exact. Corrections to the bosonic masses from (i) leading-order strong-coupling corrections to BCS theory, and (ii) polarization of the parent fermionic vacuum lead to violations of the sum rule. Results for these mass corrections are given in both the T →0 and T →Tc limits. We also discuss experimental results, and theoretical analysis, for the masses of the Jc=2± Higgs modes and the magnitude of the violation of the NSR.

  8. Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia

    PubMed Central

    Nagy, Béla; Jin, Jianguo; Ashby, Barrie; Reilly, Michael P.; Kunapuli, Satya P.

    2011-01-01

    Summary Background In hypercholesterolemia, platelets demonstrate increased reactivity and promote the development of cardiovascular disease. Objective This study was carried out to investigate the contribution of the ADP receptor P2Y12-mediated pathway in platelet hyperreactivity due to hypercholesterolemia. Methods Low-density lipoprotein receptor deficient mice and C57Bl/6 wild type mice were fed on normal chow and high-fat (Western or Paigen) diets for 8 weeks to generate differently elevated cholesterol levels. P2Y12 receptor induced functional responses via Gi signaling were studied ex vivo when washed murine platelets were activated by 2MeSADP and PAR4 agonist AYPGKF in the presence and absence of indomethacin. Platelet aggregation, secretion, αIIbβ3 receptor activation and the phosphorylation of extracellular signal-regulated protein kinase (ERK) and Akt were analyzed. Results Plasma cholesterol levels ranged from 69±10 to 1011±185 mg/dl depending on diet in mice with different genotypes. Agonist-dependent aggregation, dense and α-granule secretion and JON/A binding were gradually and significantly (P < 0.05) augmented at low agonist concentration in correlation with the increasing plasma cholesterol levels even if elevated thromboxane generation was blocked. These functional responses were induced via increased level of Gi mediated ERK and Akt phosphorylation in hypercholesterolemic mice versus normocholesterolemic animals. In addition, blocking of the P2Y12 receptor by AR-C69931MX (Cangrelor) resulted in strongly reduced platelet aggregation in mice with elevated cholesterol levels compared to normocholesterolemic controls. Conclusions These data revealed that the P2Y12 receptor pathway was substantially involved in platelet hyperreactivity associated with mild and severe hypercholesterolemia. PMID:21261805

  9. Full sky study of diffuse Galactic emission at decimeter wavelengths

    NASA Astrophysics Data System (ADS)

    Platania, P.; Burigana, C.; Maino, D.; Caserini, E.; Bersanelli, M.; Cappellini, B.; Mennella, A.

    2003-11-01

    A detailed knowledge of the Galactic radio continuum is of high interest for studies of the dynamics and structure of the Galaxy as well as for the problem of foreground removal in Cosmic Microwave Background measurements. In this work we present a full-sky study of the diffuse Galactic emission at frequencies of few GHz, where synchrotron radiation is by far the dominant component. We perform a detailed combined analysis of the extended surveys at 408, 1420 and 2326 MHz (by Haslam et al. 1982; Reich 1982; Reich & Reich 1986; Jonas et al. 1998, respectively). Using the technique applied by Schlegel et al. (1998) to the IRAS data, we produce destriped versions of the three maps. This allows us to construct a nearly-full-sky map of the spectral index and of the normalization factor with sub-degree angular resolution. The resulting distribution of the spectral indices has an average of bar beta = 2.695 and dispersion sigma beta = 0.120. This is representative for the Galactic diffuse synchrotron emission, with only minor effects from free-free emission and point sources. The maps produced in this work are available via ftp at cdsarc.u-strasbg.fr The maps produced in this work are only available in electronic form via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg/cgi-bin/qcat?J/A+A/410/847 Colour figures are only available in the electronic edition of this paper via http://www.edpsciences.org

  10. Anisotropic propagator for the Goldstone modes in color-flavor locked phase in the presence of a magnetic field

    NASA Astrophysics Data System (ADS)

    Sen, Srimoyee

    2015-07-01

    We consider the phase diagram of QCD at very high baryon density and at zero temperature in the presence of a strong magnetic field. The state of matter at such high densities and low temperatures is believed to be a phase known as the color-flavor locked phase which breaks color and electromagnetic gauge invariance, leaving a linear combination of them, denoted as U (1 )e m ˜ , unbroken. Of the nine quarks (three flavors and three colors), five are neutral under this unbroken generator and four are oppositely charged (two with a charge of +1 and two with -1 ). In the presence of a magnetic field corresponding to U (1 )em ˜, however, the properties of the condensate change and a new phase known as the magnetic color-flavor locked (MCFL) phase is realized. This phase breaks an approximate S U (3 )C×S U (2 )L×S U (2 )R×U (1 )B×U (1 )A- symmetry of the Lagrangian to S U (2 )C+L +R×U (1 )em ˜ giving rise to six Goldstone modes, five of which are pseudo Goldstone modes. These Goldstone modes are composed of excitations that correspond to both neutral quarks and charged quarks. Hence it is natural to expect that the propagators of these Goldstone modes are affected in the presence of a magnetic field, and their speed becomes considerably anisotropic. Although this anisotropy is self-evident from symmetry arguments, it has not been quantified yet. We calculate this anisotropy in the speed of the Goldstone modes using a Nambu-Jona-Lasinio model type of interaction between the quarks and comment on the impact of such anisotropic modes on transport properties of the MCFL phase.

  11. QCD phenomenology based on a chiral effective Lagrangian

    NASA Astrophysics Data System (ADS)

    Hatsuda, Tetsuo; Kunihiro, Teiji

    1994-10-01

    We review the Nambu-Jona-Lasinio (NJL) approach to the dynamical breaking of chiral symmetry in Quantum Chromodynamics (QCD). After a general overview of the nonperturbative aspects of OCD, we introduce the NJL model as a low-energy effective theory of QCD. The collective nature of hadrons and the constituent quark model are treated in a unified way. Various aspects of QCD related to the dynamical and explicit breaking of chiral symmetry and the axial anomaly can be well described. The subjects treated in part I include the vacuum structure of QCD, mass spectra and coupling constants of hadrons, flavor mixing in mesons, the violation of the OZI rule in baryons, and the validity of the chiral perturbation in QCD. It is shown that a subtle interplay between the axial anomaly and the current-quark masses plays important roles, and a realistic evaluation of the strangeness and heavy quark contents of hadrons is given. Also the problem of elusive scalar mesons is studied in detail. For a pedagogical reason, we first present an account of basic ingredients and detailed technical aspects of the NJL model using simple versions of it. In part II, the NJL model is applied to the system at finite temperature ( T) and density (ϱ) relevant to the early universe, interior of the neutron stars and the ultrarelativistic heavy ion collisions. After a brief introduction of the field theory at finite temperature, phenomena associated with the restoration of chiral symmetry in the medium are examined. The subjects treated here include the quark condensates in the medium, meson properties at finite T (ϱ) and their experimental implications. A special attemtion is paid to fluctuation phenomena near the critical temperature, i.e., possible existence of soft modes in the scalar channel and a jump of the quark-number susceptibility in the vector channel.

  12. Spinodal instabilities of baryon-rich quark matter in heavy ion collisions

    NASA Astrophysics Data System (ADS)

    Li, Feng; Ko, Che Ming

    2017-05-01

    Using the test-particle method to solve the transport equation derived from the Nambu-Jona-Lasino (NJL) model, we study how phase separation occurs in expanding quark matter like that in a heavy ion collision. To test our method, we first investigate the growth rates of unstable modes of quark matter in a static cubic box and find them to agree with the analytical results that were previously obtained using the linear response theory. In this case, we also study the higher-order scaled density moments in the quark matter, which have values of 1 for a uniform density distribution or a distribution where the nonzero density regions all have same value, and they are found to increase with time and saturate at values significantly larger than 1 after the phase separation. The skewness of the quark number event-by-event distribution in a small subvolume of the system is also found to increase, but this feature disappears if the subvolume is large. For the expanding quark matter, two cases are considered: one using a blast-wave model for the initial conditions and the other using initial conditions from a multiphase transport (AMPT) model. In both cases, we find that the expansion of the quark matter is slowed down by the presence of a first-order phase transition. Also, density clumps appear in the system and the momentum distribution of partons becomes anisotropic, which can be characterized by large scale density moments and nonvanishing anisotropic elliptic and quadrupolar flows, respectively. The large density fluctuations further lead to an enhancement in the dilepton yield. In the case with the AMPT initial conditions, the presence of a first-order phase transition also results in a narrower distribution of partons in rapidity. These effects of density fluctuations can be regarded as possible signals for a first-order phase transition that occurs in the baryon-rich quark matter formed in relativistic heavy ion collisions.

  13. Anomalous decay f1(1285 )→ρ γ and related processes

    NASA Astrophysics Data System (ADS)

    Osipov, A. A.; Pivovarov, A. A.; Volkov, M. K.

    2017-09-01

    We work out the low-energy expansion of the anomalous f1(1285 )→ρ γ decay amplitude by using the Nambu-Jona-Lasinio model with U (2 )×U (2 ) chiral symmetric four-quark interactions in the one-quark-loop approximation. The related processes f1(1285 )→ω γ , a1(1260 )→ω γ , and a1(1260 )→ρ γ , are also considered. An effective meson Lagrangian responsible for f1ρ γ , f1ω γ , a1ρ γ and a1ω γ interactions is found. The predicted radiative decay widths, Γf1→ρ0γ=311 keV , Γf1→ωγ=34.3 keV , Γa1→ρ0γ=26.8 keV , Γa1→ωγ=238 keV , allow an experimental test of the hypothesis that f1(1285 ) and a1(1260 )-mesons have a quark-antiquark nature. At present, only the f1(1285 )→ρ γ decay has been measured. Our result is in remarkably good agreement with the recent data of CLAS Collaboration Γf1→ρ0γ=453 ±177 keV , but disagrees with the Particle Data Group-based estimate of Γf1→ρ0γ=1326 ±313 keV . The calculations presented require a minimum of theoretical input, and are shown to be consistent with the nonrenormalization theorems of QCD.

  14. Artificial Reefs in Motion: Legacy of changes and degradation at the Redbird Reef Site

    NASA Astrophysics Data System (ADS)

    Trembanis, A. C.; DuVal, C.; Peter, B.

    2016-12-01

    Artificial reefs are used for a variety of purposes at sites throughout the U.S. and around the globe, yet little, if any, long-term monitoring has been conducted with the goal of understanding inter-annual changes to the emplaced structures. Throughout the U.S. Mid-Atlantic region, several programs utilized retired subway cars as disposal structures to form artificial reefs. One such site, known as site 11, or "Redbird Reef", is located off the coast of Delaware and was at one time home to 997 former NYC subway cars. Opportunistic sonar surveys at the site have been conducted between 2008 and 2016 providing one of the most extensive and repeated mapping studies for this type of reef. Previous studies conducted by our group at the site have focused on understanding wave orbital ripple dynamics and scour patterns. In this present study, we analyze the changes apparent at the site itself, focused on the storm-response dynamics of the subway cars. Results have shown that Superstorm Sandy in 2012 produced dramatic changes to the reef structures resulting in the total or partial destruction of eight subway cars within a small (.45 x .2km) portion of the reef site. Winter Storm Jonas in 2016 resulted in the destruction of fewer cars, but rotated a previously static 47m long Navy barge nearly 60 degrees. Once destroyed or collapsed by waves the subway cars go from providing positive structural relief and thus beneficial habitat above the surrounding seabed to being reduced to scattered low relief marine debris. A once popular consideration for reef material, the event and inter-annual decay of subway cars as observed at the Redbird reef provides both a stark indication of the power of storm dynamics on the inner-shelf and a cautionary tale with regards to the selection of seabed reef material.

  15. Effective field theories of baryons and mesons, or, what do quarks do?

    SciTech Connect

    Keaton, G.L.

    1995-06-26

    This thesis is an attempt to understand the properties of the protons, pions and other hadrons in terms of their fundamental building blocks. In the first chapter the author reviews several of the approaches that have already been developed. The Nambu-Jona-Lasinio model offers the classic example of a derivation of meson properties from a quark Lagrangian. The chiral quark model encodes much of the intuition acquired in recent decades. The author also discusses the non-linear sigma model, the Skyrme model, and the constituent quark model, which is one of the oldest and most successful models. In the constituent quark model, the constituent quark appears to be different from the current quark that appears in the fundamental QCD Lagrangian. Recently it was proposed that the constituent quark is a topological soliton. In chapter 2 the author investigates this soliton, calculating its mass, radius, magnetic moment, color magnetic moment, and spin structure function. Within the approximations used, the magnetic moments and spin structure function cannot simultaneously be made to agree with the constituent quark model. In chapter 3 the author uses a different plan of attack. Rather than trying to model the constituents of the baryon, he begins with an effective field theory of baryons and mesons, with couplings and masses that are simply determined phenomenologically. Meson loop corrections to baryon axial currents are then computed in the 1/N expansion. It is already known that the one-loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by 1/N{sup 2}. To leading order, these corrections are exactly the same as would be calculated in the constituent quark model. This method therefore offers a different approach to the constituent quark.

  16. Tools for Studying Electron and Spin Transport in Single Molecules

    NASA Astrophysics Data System (ADS)

    Ralph, Daniel C.

    2005-03-01

    Experiments in the field of single-molecule electronics are challenging in part because it can be very difficult to control and characterize the device structure. Molecules contacted by metal electrodes cannot easily be imaged by microscopy techniques. Moreover, if one attempts to characterize the device structure simply by measuring a current-voltage curve, it is easy to mistake nonlinear transport across a bare tunnel junction or a metallic short for a molecular signal. I will discuss the development of a set of experimental test structures that enable the properties of a molecular device to be tuned controllably in-situ, so that the transport mechanisms can be studied more systematically and compared with theoretical predictions. My collaborators and I are developing the means to use several different types of such experimental "knobs" in coordination: electrostatic gating to shift the energy levels in a molecule, mechanical motion to adjust the molecular configuration or the molecule-electrode coupling strength, illumination with light to promote electrons to excited states or to make and break chemical bonds, and the use of ferromagnetic electrodes to study spin-polarized transport. Our work so far has provided new insights into Kondo physics, the coupling between a molecule's electronic and mechanical degrees of freedom, and spin transport through a molecule between magnetic electrodes. Collaborators: Radek Bialczak, Alex Champagne, Luke Donev, Jonas Goldsmith, Jacob Grose, Janice Guikema, Jiwoong Park, Josh Parks, Abhay Pasupathy, Jason Petta, Sara Slater, Burak Ulgut, Alexander Soldatov, H'ector Abruña, and Paul McEuen.

  17. Kinetically Controlled Alteration of the Chemical Record During Diagenesis: An Experimental Study on Hydrothermal Carbonate Replacement

    NASA Astrophysics Data System (ADS)

    Mueller, T.; Dohmen, R.; Jonas, L.; Immenhauser, A.

    2016-12-01

    The geological record stored in the geochemical composition of carbonates provides a direct source of information on the Earth systems. However, the robustness and accuracy of these key records can be compromised by post-depositional alteration of sediments, such as dolomitization during diagenesis or low temperature metamorphism. Hence, knowledge on the mechanisms and rates of these processes hold the key to evaluate the robustness of proxies or to evaluate the extent of geochemical alteration. Previously, we presented experimental results of hydrothermal alteration of single calcite crystals and aragonitic coral fragments leading to replacement of the original carbonate by a Ca-Mg carbonate phase of variable composition. The experiments revealed the formation of a multiphase reaction rim with multiple replacement fronts [1]. Here, the reaction rate as well as composition of the reaction products is controlled by element transport in the pore fluid. In this study we focus on the reaction path of the replacement reaction and its effect on the recorded Mg-isotope composition. XRD diffraction patterns suggest the initial precipitation of non-ordered protodolomite that is subsequently continuously recrystallizing over the duration of the experiments to form an ordered, albeit non-stoichiometric dolomite. These observations are in agreement with Mg-isotope composition measured of the bulk reaction rim showing a systematic evolution over time that cannot be explained by simple Rayleigh or equilibrium fractionation. We interpret these findings as additional, but delayed reaction fronts affecting the microstructure and chemical composition of the newly formed carbonate rim that are essentially decoupled from the initial replacement front. Our results highlight the need to quantitatively understand alteration processes during diagenesis in order to accurately interpret the preserved geochemical record stored in element and isotope ratios of carbonates. [1] Jonas L

  18. Properties of mesons in a strong magnetic field.

    PubMed

    Zhang, Rui; Fu, Wei-Jie; Liu, Yu-Xin

    By extending the [Formula: see text]-derivable approach in the Nambu-Jona-Lasinio model to a finite magnetic field we calculate the properties of pion, [Formula: see text], and [Formula: see text] mesons in a magnetic field at finite temperature not only in the quark-antiquark bound state scheme but also in the pion-pion scattering resonant state scenario. Our calculation as a result makes manifest that the masses of [Formula: see text] and [Formula: see text] meson can be nearly degenerate at the pseudo-critical temperature which increases with increasing magnetic field strength, and the [Formula: see text] mass ascends suddenly at almost the same critical temperature. Meanwhile the [Formula: see text] mesons' masses decrease with the temperature but increase with the magnetic field strength. We also check the Gell-Mann-Oakes-Renner relation and find that the relation can be violated clearly with increasing temperature, and the effect of the magnetic field becomes pronounced around the critical temperature. With different criteria, we analyze the effect of the magnetic field on the chiral phase transition and find that the pseudo-critical temperature of the chiral phase cross, [Formula: see text], is always enhanced by the magnetic field. Moreover, our calculations indicate that the [Formula: see text] mesons will get melted as the chiral symmetry has not yet been restored, but the [Formula: see text] meson does not disassociate even at very high temperature. Particularly, it is the first to show that there does not exist a vector meson condensate in the QCD vacuum in the pion-pion scattering scheme.

  19. Chiral quark dynamics and topological charge: The role of the Ramond-Ramond U(1) gauge field in holographic QCD

    NASA Astrophysics Data System (ADS)

    Thacker, H. B.; Xiong, Chi; Kamat, Ajinkya S.

    2011-11-01

    The Witten-Sakai-Sugimoto construction of holographic QCD in terms of D4 color branes and D8 flavor branes in type IIA string theory is used to investigate the role of topological charge in the chiral dynamics of quarks in QCD. The QCD theta term arises from a compactified five-dimensional Chern-Simons term on the D4 branes. This term couples the QCD topological charge to the Ramond-Ramond (RR) U(1) gauge field of type IIA string theory. For large Nc the contribution of instantons (D0 branes) is suppressed, and the nonzero topological susceptibility of pure-glue QCD is attributed to the presence of D6 branes, which constitute magnetic sources of the RR gauge field. The topological charge of QCD is required, by an anomaly inflow argument, to coincide in space-time with the intersection of the D6 branes and the D4 color branes. This clarifies the relation between D6 branes and the coherent, codimension-one topological charge membranes observed in QCD Monte Carlo calculations. Using open-string/closed-string duality, we interpret a quark loop (represented by a D4-D8 open-string loop) in terms of closed-string exchange between color and flavor branes. The role of the RR gauge field in quark-antiquark annihilation processes is discussed. RR exchange in the s-channel generates a 4-quark contact term which produces an η' mass insertion and provides an explanation for the observed spin-parity structure of the Okubo-Zweig-Iizuka rule. The (log⁡DetU)2 form of the U(1) anomaly emerges naturally. RR exchange in the t-channel of the qq¯ scattering amplitude produces a Nambu-Jona-Lasinio interaction which may provide a mechanism for spontaneous breaking of SU(Nf)×SU(Nf).

  20. Gaussian process test for high-throughput sequencing time series: application to experimental evolution

    PubMed Central

    Topa, Hande; Jónás, Ágnes; Kofler, Robert; Kosiol, Carolin; Honkela, Antti

    2015-01-01

    Motivation: Recent advances in high-throughput sequencing (HTS) have made it possible to monitor genomes in great detail. New experiments not only use HTS to measure genomic features at one time point but also monitor them changing over time with the aim of identifying significant changes in their abundance. In population genetics, for example, allele frequencies are monitored over time to detect significant frequency changes that indicate selection pressures. Previous attempts at analyzing data from HTS experiments have been limited as they could not simultaneously include data at intermediate time points, replicate experiments and sources of uncertainty specific to HTS such as sequencing depth. Results: We present the beta-binomial Gaussian process model for ranking features with significant non-random variation in abundance over time. The features are assumed to represent proportions, such as proportion of an alternative allele in a population. We use the beta-binomial model to capture the uncertainty arising from finite sequencing depth and combine it with a Gaussian process model over the time series. In simulations that mimic the features of experimental evolution data, the proposed method clearly outperforms classical testing in average precision of finding selected alleles. We also present simulations exploring different experimental design choices and results on real data from Drosophila experimental evolution experiment in temperature adaptation. Availability and implementation: R software implementing the test is available at https://github.com/handetopa/BBGP. Contact: hande.topa@aalto.fi, agnes.jonas@vetmeduni.ac.at, carolin.kosiol@vetmeduni.ac.at, antti.honkela@hiit.fi Supplementary information: Supplementary data are available at Bioinformatics online. PMID:25614471

  1. Biomolecular simulation on thousands of processors

    NASA Astrophysics Data System (ADS)

    Phillips, James Christopher

    Classical molecular dynamics simulation is a generally applicable method for the study of biomolecular aggregates of proteins, lipids, and nucleic acids. As experimental techniques have revealed the structures of larger and more complex biomolecular machines, the time required to complete even a single meaningful simulation of such systems has become prohibitive. We have developed the program NAMD to simulate systems of 50,000--500,000 atoms efficiently with full electrostatics on parallel computers with 1000 and more processors. NAMD's scalability is achieved through latency tolerant adaptive message-driven execution and measurement-based load balancing. NAMD is implemented in C++ and uses object-oriented design and threads to shield the basic algorithms from the necessary complexity of high-performance parallel execution. Apolipoprotein A-I is the primary protein constituent of high density lipoprotein particles, which transport cholesterol in the bloodstream. In collaboration with A. Jonas, we have constructed and simulated models of the nascent discoidal form of these particles, providing theoretical insight to the debate regarding the lipid-bound structure of the protein. Recently, S. Sligar and coworkers have created 10 nm phospholipid bilayer nanoparticles comprising a small lipid bilayer disk solubilized by synthetic membrane scaffold proteins derived from apolipoprotein A-I. Membrane proteins may be embedded in the water-soluble disks, with various medical and technological applications. We are working to develop variant scaffold proteins that produce disks of greater size, stability, and homogeneity. Our simulations have demonstrated a significant deviation from idealized cylindrical structure, and are being used in the interpretation of small angle x-ray scattering data.

  2. Sleep Disordered Breathing During Live High-Train Low in Normobaric Versus Hypobaric Hypoxia.

    PubMed

    Saugy, Jonas J; Schmitt, Laurent; Fallet, Sibylle; Faiss, Raphael; Vesin, Jean-Marc; Bertschi, Mattia; Heinzer, Raphaël; Millet, Grégoire P

    2016-09-01

    Saugy, Jonas J., Laurent Schmitt, Sibylle Fallet, Raphael Faiss, Jean-Marc Vesin, Mattia Bertschi, Raphaël Heinzer, and Grégoire P. Millet. Sleep disordered breathing during live high-train low in normobaric versus hypobaric hypoxia. High Alt Med Biol. 17:233-238, 2016.-The present study aimed to compare sleep disordered breathing during live high-train low (LHTL) altitude camp using normobaric hypoxia (NH) and hypobaric hypoxia (HH). Sixteen highly trained triathletes completed two 18-day LHTL camps in a crossover designed study. They trained at 1100-1200 m while they slept either in NH at a simulated altitude of 2250 m or in HH. Breathing frequency and oxygen saturation (SpO2) were recorded continuously during all nights and oxygen desaturation index (ODI 3%) calculated. Breathing frequency was lower for NH than HH during the camps (14.6 ± 3.1 breath × min(-1) vs. 17.2 ± 3.4 breath × min(-1), p < 0.001). SpO2 was lower for HH than NH (90.8 ± 0.3 vs. 91.9 ± 0.2, p < 0.001) and ODI 3% was higher for HH than NH (15.1 ± 3.5 vs. 9.9 ± 1.6, p < 0.001). Sleep in moderate HH is more altered than in NH during a LHTL camp.

  3. [Towards a new vaccine economy?].

    PubMed

    Poirot, P; Martin, J F

    1994-01-01

    When Jonas Salk announced in the mid-50s the availability of a new vaccine against poliomyelitis, the world had the impression that it was now controlling infectious diseases. In fact, the success of this vaccine has been considerable and although some innovations lead to the launch of vaccines against flu, measles, rubella or mumps, the world vaccine market remained remarkably stable till the mid-80s. However, since 1984 (launch of the hepatitis B vaccine) there have been very substantial changes and further change is expected in the next ten years in the world market. Today, big companies are making a concentrated supply: Pasteur Mérieux with its subsidiary Connaught, SmithKline Beecham who acquired the Belgian company RIT, and Merck & Co. who is joining its forces with Pasteur Mérieux. Medium sized and small companies remain and reflect the situation of the past, but must work hard to secure their long term existence eventhough the world demand is going to double before the year 2000. Very substantial technological innovations explain to a large extent the development of the supply: progress in molecular biology, and particularly genetic engineering, lead to recombinant vaccines of which hepatitis B is the best example with worldwide sales in the range of $600 million a year. Similarly, conjugation technologies have allowed the development of new vaccines against meningitis, particularly Haemophilus influenzae type b. More recently, an efficacious vaccine against hepatitis A has been launched and many new products will be marketed in the next years against herpes, Lyme disease, and agents of other meningitis, etc.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Properties of 2 +1 -flavor QCD in the imaginary chemical potential region: A model approach

    NASA Astrophysics Data System (ADS)

    Sugano, Junpei; Kouno, Hiroaki; Yahiro, Masanobu

    2017-07-01

    We study properties of 2 +1 -flavor QCD in the imaginary chemical potential region by using two approaches. One is a theoretical approach based on the QCD partition function, and the other is a qualitative one based on the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. In the theoretical approach, we clarify conditions imposed on the imaginary chemical potentials μf=i θfT to realize the Roberge-Weiss (RW) periodicity. Here, T is the temperature, the index f denotes the flavor, and θf are dimensionless chemical potentials. We also show that the RW periodicity is broken if any one of θf is fixed to a constant value. In order to visualize the condition, we use the PNJL model as a model possessing the RW periodicity and draw the phase diagram as a function of θu=θd≡θl for two conditions of θs=θl and θs=0 . We also consider two cases, (μu,μd,μs)=(i θuT ,i C1T ,0 ) and (μu,μd,μs)=(i C2T ,i C2T ,i θsT ); here, C1 and C2 are dimensionless constants, whereas θu and θs are treated as variables. For some choice of C1 (C2), the number density of the up (strange) quark becomes smooth in the entire region of θu (θs) even in the high T region. This property may be important for lattice QCD simulations in the imaginary chemical potential region, since it makes the analytic continuation more feasible.

  5. Single-flavor CSL phase in compact stars

    SciTech Connect

    Blaschke, David; Sandin, Fredrik; Klaehn, Thomas; Berdermann, Jens

    2008-08-29

    We suggest a scenario where the three light quark flavors are sequentially deconfined under increasing pressure in cold asymmetric nuclear matter as, e.g., in neutron stars. The basis for our analysis is a chiral quark matter model of Nambu-Jona-Lasinio (NJL) type with diquark pairing in the spin-1 single flavor (CSL), spin-0 two flavor (2SC) and three flavor (CFL) channels. We find that nucleon dissociation sets in at about the saturation density, n{sub 0}, when the down-quark Fermi sea is populated (d-quark dripline) due to the flavor asymmetry induced by {beta}-equilibrium and charge neutrality. At about 3n{sub 0} u-quarks appear and a two-flavor color superconducting (2SC) phase is formed. The s-quark Fermi sea is populated only at still higher baryon density, when the quark chemical potential is of the order of the dynamically generated strange quark mass. We construct two different hybrid equations of state (EoS) using the Dirac-Brueckner Hartree-Fock (DBHF) approach and the EoS by Shen et al. in the nuclear matter sector. The corresponding hybrid star sequences have maximum masses of, respectively, 2.1 and 2.0 M{sub {center_dot}}. Two- and three-flavor quark-matter phases exist only in gravitationally unstable hybrid star solutions in the DBHF case, while the Shen-based EoS produce stable configurations with a 2SC phase component in the core of massive stars. Nucleon dissociation due to d-quark drip at the crust-core boundary fulfills basic criteria for a deep crustal heating process which is required to explain superbusts as well as cooling of X-ray transients.

  6. Phase diagram of three-flavor quark matter under compact star constraints

    SciTech Connect

    Blaschke, D.; Fredriksson, S.; Sandin, F.; Grigorian, H.; Oeztas, A.M.

    2005-09-15

    The phase diagram of three-flavor quark matter under compact star constraints is investigated within a Nambu-Jona-Lasinio model. Global color and electric charge neutrality is imposed for {beta}-equilibrated superconducting quark matter. The constituent quark masses and the diquark condensates are determined self-consistently in the plane of temperature and quark chemical potential. Both strong and intermediate diquark coupling strengths are considered. We show that in both cases, gapless superconducting phases do not occur at temperatures relevant for compact star evolution, i.e., below T{approx}50 MeV. The stability and structure of isothermal quark star configurations are evaluated. For intermediate coupling, quark stars are composed of a mixed phase of normal (NQ) and two-flavor superconducting (2SC) quark matter up to a maximum mass of 1.21 M{sub {center_dot}}. At higher central densities, a phase transition to the three-flavor color flavor locked (CFL) phase occurs and the configurations become unstable. For the strong diquark coupling we find stable stars in the 2SC phase, with masses up to 1.33 M{sub {center_dot}}. A second family of more compact configurations (twins) with a CFL quark matter core and a 2SC shell is also found to be stable. The twins have masses in the range 1.30...1.33 M{sub {center_dot}}. We consider also hot isothermal configurations at temperature T=40 MeV. When the hot maximum mass configuration cools down, due to emission of photons and neutrinos, a mass defect of 0.1 M{sub {center_dot}} occurs and two final state configurations are possible.

  7. U{sub A}(1) anomaly in hot and dense QCD and the critical surface

    SciTech Connect

    Chen, J.-W.; Fukushima, Kenji; Kohyama, Hiroaki; Ohnishi, Kazuaki; Raha, Udit

    2009-09-01

    We discuss the chiral phase transition in hot and dense QCD with three light flavors. Inspired by the well-known fact that the U{sub A}(1) anomaly could induce first order phase transitions, we study the effect of the possible restoration of the U{sub A}(1) symmetry at finite density. In particular, we explore the link between the U{sub A}(1) restoration and the recent lattice QCD results of de Forcrand and Philipsen, in which the first order phase transition region near zero chemical potential ({mu}) shrinks in the quark mass and {mu} space when {mu} is increased. Starting from the Ginzburg-Landau theory for general discussions, we then use the Nambu-Jona-Lasinio model for quantitative studies. With the partial U{sub A}(1) restoration modeled by the density dependent 't Hooft interaction, we fit the shrinking of the first order region found in de Forcrand and Philipsen's lattice calculation at low {mu}. At higher {mu}, the first order region might shrink or expand, depending on the scenarios. This raises the possibility that despite the shrinking of the first order region at lower {mu}, the QCD critical end point might still exist due to the expansion at higher {mu}. In this case, very high precision lattice data will be needed to detect the recently observed backbending of the critical surface with the currently available analytic continuation or Taylor expansion approaches. Lattice computations could, however, test whether the U{sub A}(1) restoration is responsible for the shrinking of the first order region by computing the {eta}{sup '} mass or the topological susceptibility at small {mu}.

  8. A Flea on Schrödinger's Cat

    NASA Astrophysics Data System (ADS)

    Landsman, N. P. (Klaas); Reuvers, Robin

    2013-03-01

    We propose a technical reformulation of the measurement problem of quantum mechanics, which is based on the postulate that the final state of a measurement is classical; this accords with experimental practice as well as with Bohr's views. Unlike the usual formulation (in which the post-measurement state is a unit vector in Hilbert space), our version actually opens the possibility of admitting a purely technical solution within the confines of conventional quantum theory (as opposed to solutions that either modify this theory, or introduce unusual and controversial interpretative rules and/or ontologies). To that effect, we recall a remarkable phenomenon in the theory of Schrödinger operators (discovered in 1981 by Jona-Lasinio, Martinelli, and Scoppola), according to which the ground state of a symmetric double-well Hamiltonian (which is paradigmatically of Schrödinger's Cat type) becomes exponentially sensitive to tiny perturbations of the potential as ħ→0. We show that this instability emerges also from the textbook wkb approximation, extend it to time-dependent perturbations, and study the dynamical transition from the ground state of the double well to the perturbed ground state (in which the cat is typically either dead or alive, depending on the details of the perturbation). Numerical simulations show that adiabatically arising perturbations may (quite literally) cause the collapse of the wave-function in the classical limit. Thus, at least in the context of a simple mathematical model, we combine the technical and conceptual virtues of decoherence (which fails to solve the measurement problem but launches the key idea that perturbations may come from the environment) with those of dynamical collapse models à la grw (which do solve the measurement problem but are ad hoc), without sharing their drawbacks: single measurement outcomes are obtained (instead of merely diagonal reduced density matrices), and no modification of quantum mechanics is needed.

  9. Protective effects of fruits and vegetables against in vivo clastogenicity of cyclosphosphamide or benzo[a]pyrene in mice.

    PubMed

    Edenharder, R; Frangart, J; Hager, M; Hofmann, P; Rauscher, R

    1998-08-01

    Seven fruits and 10 vegetables commonly consumed in Germany were investigated for their anticlastogenic potencies against cyclophosphamide (CP) and benzo[a]pyrene (BaP) in the in vivo mouse bone marrow micronucleus assay. We detected protective effects in 76.5% and 70.6% of the samples, respectively, and more or less distinct quantitative differences between the various plant materials and the two clastogens investigated. With respect to CP, moderate activities were exerted by sweet cherries, strawberries, cucumber, radish and tomatoes, average activities by bananas, oranges, peaches, asparagus and red beets and strong activities by yellow red peppers and especially spinach. Apples (cultivar Jona Gold), brussels sprouts, cauliflower and onions were inactive. With respect to BaP, we found moderate activities in strawberries, brussels sprouts and radish, average activities in sweet cherries, oranges, peaches, asparagus, red beets, cucumber and spinach and strong activities in bananas and kiwi. Apples, cauliflower, onions, tomatoes and yellow-red peppers were inactive. When oranges were fractionated according to previously described schemes (Edenharder et al., 1995), anticlastogenic activities against CP were exerted by materials extracted with n-hexane, acetone and 2-propanol and in the terminal residue, but not in the dichloromethane and water phases. With respect to BaP, materials extracted with acetone showed strong anticlastogenicity while the 2-propanol fraction, the aqueous phase and the terminal residue were less potent. The n-hexane and the dichloromethane fractions were inactive. In red beets, all fractions showed anticlastogenicity against CP and BaP as well. However, the n-hexane and dichloromethane fractions were most potent with respect to CP, while for BaP the aqueous phase and the terminal residue were most effective. These result suggest the presence of various (groups of) anticlastogenic compounds with different chemical structure.

  10. Importance of pseudoscalar-axial-vector mixing in calculation of the properties of the π, η, and η' mesons

    NASA Astrophysics Data System (ADS)

    Celenza, L. S.; Huang, Bo; Shakin, C. M.

    1999-05-01

    In this work we resolve a problem that arises in the calculation of the two-photon decay of the π0, η, and η' mesons, when use is made of the Nambu-Jona-Lasinio (NJL) model. It has been found that satisfactory results for the widths are obtained if a momentum cutoff is not introduced in the evaluation of the (convergent) integrals obtained from an analysis of the triangle diagram, while only about one-half of the experimental value is obtained, if the cutoff used for the (divergent) loop integrals of the NJL model is introduced. The resolution of this problem lies in the introduction of pseudoscalar-axial-vector mixing for both the π0 and the η-η' system. (In addition, one has singlet-octet mixing for the η and η', requiring the study of T matrices of dimension four in that case.) Since we have used a relativistic quark model that includes a (covariant) confinement model, we are able to treat the η' and η mesons on the same basis. We found that the 't Hooft interaction does not work well in our study of η-η' mixing, while the parametrization of nonperturbative effects due to coupling to gluonic modes, which affects the strength of the interaction for singlet states only, yields satisfactory results. In the case of a pion, our results may be understood by the observation that the vertex iP/γ5/P2 yields a much larger amplitude for two-photon decay of a meson of momentum P than the vertex iγ5. Therefore, quite small mixing angles can yield a large modification of the calculated width. We have found that our results are sensitive to the form of regulator used. For example, with a sharp cutoff, Γη'-->γγ is overestimated by about a factor of 3, while the use of a Gaussian regulator leads to a satisfactory fit to the experimental value.

  11. [The impacts of regulating Toll-like receptor 2/nuclear factor-ΚB signal pathway on rats with ventilator-induced lung injury].

    PubMed

    Fu, Ruili; Pan, Linghui; Lin, Fei; Ge, Wanyun; Huang, Cuiyuan; Dai, Huijun

    2014-12-01

    To evaluate the role of Toll-like receptor 2/nuclear factor-ΚB (TLR2/NF-ΚB) signaling pathway pretreatment in ventilator-induced lung injury (VILI). Thirty male Sprague-Dawley (SD) rats were randomly divided into three groups by using random number scale, with 10 rats in each group. Group A: rats were given 200 μL of TLR2 monoclonal antibodies (TLR2mAb, 10 μg/kg) by slow instillation through tracheal catheter, and then ventilated with a high tidal volume (VT) of 40 mL/kg. Group B: ventilated with a normal VT of 8 mL/kg. Group C: rats were tracheally instilled with 10 μg/kg of TLR2mAb devoid of biologic activity, and then ventilated with a high VT of 40 mL/kg. The rats were mechanically ventilated for 4 hours, the lung wet to dry weight ratio (W/D) was calculated. The changes in pathology and ultrastructure in lung tissue were observed with microscope. Enzyme linked immunosorbent assay (ELISA) was performed to determine the concentration of interleukins (IL-1β, IL-6) and tumor necrosis factor-α (TNF-α) in serum and brconchoalveolar lavage fluid (BALF). Real-time fluorescent quantitation reverse transcription-polymerase chain reaction (RT-PCR) was used to assess the mRNA expressions of TLR2, NF-ΚB and myeloid differentiation factor 88 (MyD88) in lung tissue. No obvious pathological changes in lungs were found in group A and group B, and no obvious damages to ultra-microstructure were found in lung macrophages, typeI epithelial cell and typeII epithelial cell. In group C, pathological changes were observed, including pulmonary alveoli fusion, alveoli septum thickening, inflammatory cells infiltration, and damages to ultrastructure of lung macrophage, damage to cell membrane of typeI epithelial cells and type II epithelial cells, vacuoles in cytoplasm, damage to organelle, and even pyknosis and perinuclear cistern thickening. Compared with group C, W/D ratio and mean concentration of inflammatory cytokines in serum and BALF showed a significant decrease in

  12. [Analysis of the reported data of national rural cervical cancer screening project from 2012 to 2013, China].

    PubMed

    Luo, X M; Song, L; Wu, J L; Liu, Y; Di, J L; Song, B; Zheng, R M; Ma, L

    2016-04-01

    To analyze the reported data of national rural cervical cancer screening project from 2012 to 2013 and to evaluate the project implementation condition. Data of the national breast carcinoma and cervical cancer (two-cancer) screening project for rural women were collected from the online report system of key women and children's public health service programs.The screening items included: preliminary screening of cervical lesions (cervical cytology, using Traian Bethesda System(TBS) or Pap grading for classification and reporting), acetate/iodide staining (VIA/VILI), colposcopy, histopathological examination, and pathological diagnosis. The study collected the quarterly reported data from 1 183 counties of 30 provinces in 2014 and 1 130 counties of 30 provinces in 2013. Chi-square test was used to test the difference of positive detection rate, as well as precancerous cervical lesions, and cervical cancer detection rates among difference preliminary screening methods in 2012 and 2013. In 2012 and 2013, the number of cervical cancer screening was 10 621 482 and 10 321 835. The percentage of using ThinPrep cytological test as the screening method was 77.17% (n=8 196 627) and 77.07% (n=7 954 949) in 2012 and 2013, respectively. Among these ThinPrep cytological tests in these two years, 65.49% (n=5 368 194) and 71.67% (n=5 701 033) used TBS report system. The abnormality rate of colposcopy increased from 27.29% (170 063/623 161) to 31.15% (203 397/652 935) (χ(2)=2 295.94,P<0.001). The abnormality rate of histopathology test increased from 19.54% (37 992/194 394) to 35.43% (59 004/166 518) (χ(2)=11 523.58, P<0.001). All together, 27 341 cervical cancer or precancerous lesions have been detected in these two years. The detection rate of invasive cervical cancer increased from 18.02/100 000 in 2012 to 19.71/100 000 (χ(2)=7.90,P=0.005) in 2013 and that of precancerous lesions rose from 106.85/100 000 to 119.26/100 000 (χ(2)=70.82,P<0.001). The early detection rate was

  13. Testing of the bactericidal action of products based on the "hydronic" technology ("informed glass") on ATCC strains of pathogenic Gram-positive and Gram-negative bacteria and yeasts (Staphylococcus aureus, Escherichia coli, and Candida albicans).

    PubMed

    Racz, Aleksandar; Cipriŝ, Josip

    2010-04-01

    Scientific experiments were conducted with drinking water kept in "ordinary, everyday-use" glasses (drinking tumblers) and the so-called "informed" glasses (drinking tumblers), a patent-protected product supposed to have an effect on the "structure, vitality and memory of water," for which the manufacturer claims to have a wide range of positive effects on the health of patients with chronic medical problems, especially a "revitalizing" effect on water and the body (blue informed glass), additional metabolic effects such as facilitating weight loss (green informed glass), and a stress-relieving action (red informed glass). According to the claims of the patent owner, a Slovenian inventor Vili Poznik, by the use of the "orgone methodology," various transcendental, vitalizing information is purportedly coded and inscribed into the glass; this action is additionally enforced by the addition of the "magic life" symbol--a specially designed energy condenser which, together with the selected information, is permanently introduced into the liquid contained in the glass. The process of selection and transfer of information is a production secret known only to the inventors of the original "hydronic technology" for the discovery of which they have been awarded numerous prizes at innovation fairs, among others, a gold medal and a Crystal Globe at INPEX XVI exhibition in Pittsburgh, PA, in 2000. The aim of this research was to test the claims for informed glasses with respect to the bacteriocidal actions that have been claimed for these products. Given that the manufacturer attributes to the products produced by the "hydronic" technology--besides the effects on organoleptic properties of the drinking water consumed (which are subjective and liable to suggestion)--a broad bactericidal action against bacteria, yeasts, and molds but does not state a single scientific proof, the efficacy and bactericidal action of the products based on the hydronic technology were tested using

  14. Quantum field theory on toroidal topology: Algebraic structure and applications

    NASA Astrophysics Data System (ADS)

    Khanna, F. C.; Malbouisson, A. P. C.; Malbouisson, J. M. C.; Santana, A. E.

    2014-05-01

    The development of quantum theory on a torus has a long history, and can be traced back to the 1920s, with the attempts by Nordström, Kaluza and Klein to define a fourth spatial dimension with a finite size, being curved in the form of a torus, such that Einstein and Maxwell equations would be unified. Many developments were carried out considering cosmological problems in association with particle physics, leading to methods that are useful for areas of physics, in which size effects play an important role. This interest in finite size effect systems has been increasing rapidly over the last decades, due principally to experimental improvements. In this review, the foundations of compactified quantum field theory on a torus are presented in a unified way, in order to consider applications in particle and condensed matter physics. The theory on a torus ΓDd=(S1)d×RD-d is developed from a Lie-group representation and c*c*-algebra formalisms. As a first application, the quantum field theory at finite temperature, in its real- and imaginary-time versions, is addressed by focusing on its topological structure, the torus Γ41. The toroidal quantum-field theory provides the basis for a consistent approach of spontaneous symmetry breaking driven by both temperature and spatial boundaries. Then the superconductivity in films, wires and grains are analyzed, leading to some results that are comparable with experiments. The Casimir effect is studied taking the electromagnetic and Dirac fields on a torus. In this case, the method of analysis is based on a generalized Bogoliubov transformation, that separates the Green function into two parts: one is associated with the empty space-time, while the other describes the impact of compactification. This provides a natural procedure for calculating the renormalized energy-momentum tensor. Self interacting four-fermion systems, described by the Gross-Neveu and Nambu-Jona-Lasinio models, are considered. Then finite size effects on

  15. Psychosomatic medicine and the philosophy of life.

    PubMed

    Schwartz, Michael A; Wiggins, Osborne P

    2010-01-21

    Basing ourselves on the writings of Hans Jonas, we offer to psychosomatic medicine a philosophy of life that surmounts the mind-body dualism which has plagued Western thought since the origins of modern science in seventeenth century Europe. Any present-day account of reality must draw upon everything we know about the living and the non-living. Since we are living beings ourselves, we know what it means to be alive from our own first-hand experience. Therefore, our philosophy of life, in addition to starting with what empirical science tells us about inorganic and organic reality, must also begin from our own direct experience of life in ourselves and in others; it can then show how the two meet in the living being. Since life is ultimately one reality, our theory must reintegrate psyche with soma such that no component of the whole is short-changed, neither the objective nor the subjective. In this essay, we lay out the foundational components of such a theory by clarifying the defining features of living beings as polarities. We describe three such polarities: 1) Being vs. non-being: Always threatened by non-being, the organism must constantly re-assert its being through its own activity. 2) World-relatedness vs. self-enclosure: Living beings are both enclosed with themselves, defined by the boundaries that separate them from their environment, while they are also ceaselessly reaching out to their environment and engaging in transactions with it. 3) Dependence vs. independence: Living beings are both dependent on the material components that constitute them at any given moment and independent of any particular groupings of these components over time.We then discuss important features of the polarities of life: Metabolism; organic structure; enclosure by a semi-permeable membrane; distinction between "self" and "other"; autonomy; neediness; teleology; sensitivity; values. Moral needs and values already arise at the most basic levels of life, even if only human

  16. Reader-Centered Technical Writing

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2012-12-01

    an old schema. This reinforces basic engineering and mathematical design concepts. Accommodation: Here, it may work in a different manner. Writers may have to accommodate an old schema to a new object. This helps engineers to focus more on applications. Adaptation: Assimilation and accommodation are the two sides of adaptation, Jean Piaget's term for what most of us would call learning. Mathematical design concepts generated by students should be suitable for creative engineering applications. References : Phillips, D. C. and Soltis, Jonas F. (2003) "Piagetian Structures and Psychological Constructivism," in Perspectives on Learning (4th edition). New York: Teachers College Press. Salvo, Michael J. (2001). Ethics of Engagement: User-Centered Design and Rhetorical Methodology. Technical Communication Quarterly Volume 10, Issue 3, 2001. pages 273-290. http://www.ship.edu/~cgboeree/piaget.html http://owl.english.purdue.edu/owl/resource/624/01/

  17. Role of the 't Hooft interaction in the calculation of the properties of scalar mesons

    NASA Astrophysics Data System (ADS)

    Shakin, C. M.

    2002-06-01

    A survey of the literature dealing with the quark-model configurations of the scalar-isoscalar light mesons suggests that a theoretical model is needed to deal with these characterizations, since various researchers have come to widely different conclusions concerning the nature of the σ(500 600) or the f0(980), basing their analysis on an attempt to fit experimental data with models for the wave functions of these states. In an earlier work we demonstrated that our generalized Nambu Jona-Lasinio model may be used to provide a very good fit to the mixing angles and decay constants of the η(547) and η'(958) mesons. It was found that the η(547) was mainly a flavor octet state. On the other hand, when we use our model to describe the scalar-isoscalar f0(980) meson, we find that it is mainly a singlet state, in agreement with the recent suggestion of Ochs. We stress that these results for the properties of the pseudoscalar and scalar mesons arise from the different behavior of the ’t Hooft interaction in the two cases. In this work we demonstrate that the singlet-octet flavor representation largely brings the interaction matrix to diagonal form, with some residual singlet-octet mixing due, in part, to the ’t Hooft interaction and to the difference of the up (or down) and the strange quark constituent mass values. We find that, if we neglect the coupling to the two-meson continuum and use the same interaction that was used in our study of the η mesons, the f0(980) has a mass of 981 MeV and is the qq¯ state of lowest energy. That result implies that the σ(500 600) is not a qq¯ state, but is generated dynamically in ππ scattering, as well have discussed in an earlier work. We suggest that the proper treatment of the ’t Hooft interaction leads to a unified interpretation of the pseudoscalar and scalar meson characteristics.

  18. Psychosomatic medicine and the philosophy of life

    PubMed Central

    2010-01-01

    Basing ourselves on the writings of Hans Jonas, we offer to psychosomatic medicine a philosophy of life that surmounts the mind-body dualism which has plagued Western thought since the origins of modern science in seventeenth century Europe. Any present-day account of reality must draw upon everything we know about the living and the non-living. Since we are living beings ourselves, we know what it means to be alive from our own first-hand experience. Therefore, our philosophy of life, in addition to starting with what empirical science tells us about inorganic and organic reality, must also begin from our own direct experience of life in ourselves and in others; it can then show how the two meet in the living being. Since life is ultimately one reality, our theory must reintegrate psyche with soma such that no component of the whole is short-changed, neither the objective nor the subjective. In this essay, we lay out the foundational components of such a theory by clarifying the defining features of living beings as polarities. We describe three such polarities: 1) Being vs. non-being: Always threatened by non-being, the organism must constantly re-assert its being through its own activity. 2) World-relatedness vs. self-enclosure: Living beings are both enclosed with themselves, defined by the boundaries that separate them from their environment, while they are also ceaselessly reaching out to their environment and engaging in transactions with it. 3) Dependence vs. independence: Living beings are both dependent on the material components that constitute them at any given moment and independent of any particular groupings of these components over time. We then discuss important features of the polarities of life: Metabolism; organic structure; enclosure by a semi-permeable membrane; distinction between "self" and "other"; autonomy; neediness; teleology; sensitivity; values. Moral needs and values already arise at the most basic levels of life, even if only human

  19. Temporal Variability of Methane Flares on the Cascadia Margin Imaged with Swath Bathymetric Data (Ancillary Data to Cascadia Initiative Cruise AT26-02)

    NASA Astrophysics Data System (ADS)

    Trehu, A. M.

    2013-12-01

    Livelybrooks (Un. of Oregon), undergraduates participating in summer research programs at (Elizabeth Davis, Indiana Un. and Oregon State Un. REU program in Oceanography; David Clemens-Sewall, Dartmouth College and IRIS intern), community college students and faculty (Haley Domer, Portland CC; Jonas Cervantes and Greg Mulder, Linn-Benton CC), and graduate students and scientists who had applied to sailed on a Cascadia Initiative cruise (Bridget Hass, Oregon State Un.; Katherine Kirk, Cornell Un. and WHOI; Anton Ypma, Western Washington Un.; Lexi Black, CA State Un. Northridge; Samantha Black, College of Charleston). WHOI marine technician Rob Hagg and MATE Intern Arianna Johns also contributed significantly to this effort.

  20. The influence of solution composition and grain boundaries on the replacement of calcite by dolomite

    NASA Astrophysics Data System (ADS)

    Moraila Martinez, Teresita de Jesus; Putnis, Christine V.; Putnis, Andrew

    2016-04-01

    microreactors during reactive fluid flow: experimental dolomitization of a calcite marble. Contributions to Mineralogy and Petrology. 168:1045. 2. Jonas L., Müller T., Dohmen R., Baumgartner L., Putlitz B. (2015). Transport-controlled hydrothermal replacement of calcite by Mg-carbonates. Geology. doi:10.1130/G36934.1 3. Kaczmarek S.E., Sibley D.F., (2011). On the evolution of dolomite stoichiometry and cation order during high-temperature synthesis experiments: An alternative model for geochemical evolution of natural dolomites. Sedimentary Geology. 246, 30-40.

  1. Nonperturbative analysis of the spectrum of meson resonances in an ultraviolet-complete composite-Higgs model

    NASA Astrophysics Data System (ADS)

    Bizot, Nicolas; Frigerio, Michele; Knecht, Marc; Kneur, Jean-Loïc

    2017-04-01

    We consider a vectorlike gauge theory of fermions that confines at the multi-TeV scale, and that realizes the Higgs particle as a composite Goldstone boson. The weak interactions are embedded in the unbroken subgroup S p (4 ) of a spontaneously broken S U (4 ) flavor group. The meson resonances appear as poles in the two-point correlators of fermion bilinears, and include the Goldstone bosons plus a massive pseudoscalar η', as well as scalars, vectors and axial vectors. We compute the mass spectrum of these mesons, as well as their decay constants, in the chiral limit, in the approximation where the hypercolor S p (2 N ) dynamics is described by four-fermion operators, à la Nambu-Jona Lasinio. By resumming the leading diagrams in the 1 /N expansion, we find that the spin-one states lie beyond the LHC reach, while spin-zero electroweak-singlet states may be as light as the Goldstone-boson decay constant, f ˜1 TeV . We also confront our results with a set of available spectral sum rules. In order to supply composite top-quark partners, the theory contains additional fermions carrying both hypercolor and ordinary color, with an associated flavor symmetry-breaking pattern S U (6 )/S O (6 ). We identify and analyze several nontrivial features of the complete two-sector gauge theory: the 't Hooft anomaly matching conditions; the higher-dimension operator which incorporates the effects of the hypercolor axial-singlet anomaly; the coupled mass-gap equations; the mixing between the singlet mesons of the two sectors, resulting in an extra Goldstone boson η0, and novel spectral sum rules. Assuming that the strength of the four-fermion interaction is the same in the two sectors, we find that the colored vector and scalar mesons have masses ≳4 f , while the masses of colored pseudo-Goldstone bosons, induced by gluon loops, are ≳1.5 f . We discuss the scaling of the meson masses with the values of N , of the four-fermion couplings, and of a possible fermion mass.

  2. The golden jubilee of vaccination against poliomyelitis.

    PubMed

    John, T Jacob

    2004-01-01

    Inactivated poliovirus vaccine (IPV), developed in the USA by Jonas Salk in the early 1950s, was field tested in 1954, and found to be safe and effective. The year 2004 marks the golden jubilee of this breakthrough. From 1955 IPV was used extensively in the US and polio incidence declined by more than 95 per cent. However, in 1962, when oral poliovirus vaccine (OPV) became available, the national policy was shifted to its exclusive use, for reasons other than science and economics. The World Health Organisation (WHO) also adopted the policy of the exclusive use of OPV in developing countries. Thus IPV fell into disrepute in much of the world, while Northern European countries continued to use it. New research led to improving its potency, reducing its manufacturing costs and combining it with the diphtheria-tetanus-pertussis (DTP) vaccine to simplify its administration and reduce programmatic costs. All countries that chose to persist with IPV eliminated poliovirus circulation without OPV-induced polio or the risk of live vaccine viruses reverting to wild-like nature. IPV is highly immunogenic, confers mucosal immunity and exerts herd protective effect, all qualities of a good vaccine. It can be used in harmony with the extendend programme on immunization (EPI) schedule of infant immunisation with DTP, thus reducing programmatic costs. During the last ten years IPV has once again regained its popularity and some 25 industrialised countries use it exclusively. The demand is increasing from other countries and the supply has not caught up, leaving market forces to dictate the sale price of IPV. Anticipating such a turn of events India had launched its own IPV manufacturing programme in 1987, but the project was closed in 1992. Today it is not clear if we can complete the job of global polio eradication without IPV, on account of the genetic instability of OPV and the consequent tendency of vaccine viruses to revert to wild-like properties. The option to use IPV is

  3. Poliomyelitis and the control programme.

    PubMed

    Basu, R N

    1985-01-01

    Poliomyelitis, an acute infectious disease which chiefly affects the central nervous system, is included in the list of 20 communicable diseases which are to be reported monthly by all institutions to the State Bureau of Health Intelligence for onward transmission to India's Central Bureau of Health Intelligence (CBHI). The reported number of 17,441 cases of poliomyelitis (annual average) since 1974 fail to reflect the magnitude of the problem in India. Directorate General of Health Services (DHGS) in collaboration with the State health authorities organized sample lameness surveys of children 5-9 years in the community during 1981-82. Poliomyelitis was found to be the major cause of lameness in children 5-9 years (64.5%). Data on admission of poliomyelitis cases from selected hospital in metropolitan cities were collected. All the hospitals reported maximum number of polio cases (more than 78%) below the age of 2 years. This data reinforce the importance of improving vaccination coverage in the age group most affected. High incidence of poliomyelitis (45% of the cases) were observed during July, August, and September, corresponding to the well demarcated monsoon season. This suggests a need to intensify immunization coverage during the low polio incidence period, namely, November to April. Polio vaccine was introduced in the national immunization program in 1980. The schedule recommends 3 doses of oral polio vaccine (OPV), starting from the age of 3 months with intervals not less than 1 month. DPT and polio vaccine are administered to the child at the same time. 1 booster dose of OPV is recommended 12-18 months later. The live attenuated OPV, not produced in India is used in the national program. The requirement of the program is met by import of bulk concentrated vaccine separately for type 1, type 2, and type 3. Then, it is diluted, blended, and ampouled by Haffkine Biopharmaceutical Corporation, Ltd. The recent visit of Dr. Jonas Salk has raised the issue of

  4. Local Geostatistical Models and Big Data in Hydrological and Ecological Applications

    NASA Astrophysics Data System (ADS)

    Hristopulos, Dionissios

    2015-04-01

    helps to overcome a significant computational bottleneck of geostatistical models due to the poor scaling of the matrix inversion [4,5]. We present applications to real and simulated data sets, including the Walker lake data, and we investigate the SLI performance using various statistical cross validation measures. References [1] T. Hofmann, B. Schlkopf, A.J. Smola, Annals of Statistics, 36, 1171-1220 (2008). [2] D. T. Hristopulos, SIAM Journal on Scientific Computing, 24(6): 2125-2162 (2003). [3] D. T. Hristopulos and S. N. Elogne, IEEE Transactions on Signal Processing, 57(9): 3475-3487 (2009) [4] G. Jona Lasinio, G. Mastrantonio, and A. Pollice, Statistical Methods and Applications, 22(1):97-112 (2013) [5] Sun, Y., B. Li, and M. G. Genton (2012). Geostatistics for large datasets. In: Advances and Challenges in Space-time Modelling of Natural Events, Lecture Notes in Statistics, pp. 55-77. Springer, Berlin-Heidelberg.

  5. Dynamical generation of Majorana masses

    SciTech Connect

    Abada, A.; Le Yaouanc, A.; Oliver, L.; Pene, O.; Raynal, J. )

    1990-09-01

    We address the general question of the dynamical generation of Majorana masses through quartic interactions of the Nambu--Jona-Lasinio (NJL) type that have both chiral and lepton-number invariances. We make composite the Higgs field of the schemes of spontaneous breaking of the leptonic number; we can thus assign to it a leptonic number {vert bar}{ital L}{vert bar}=2 in a natural way. We consider a Weyl field and write a quartic self-interaction for this field that dynamically breaks chiral and fermion-number invariances and exhibits a whole spectrum of composite particles with different quantum numbers, in addition to a Goldstone Majoron. We compare in detail the Dirac and the Majorana cases. The vacuum degeneracy is the same in both cases, but the vacuum invariances are not. For a single fermion species, we have for the Dirac case a U(1){sub {ital V}{minus}{ital A}}{times}U(1){sub {ital V}+{ital A}} invariance that breaks down to U(1){sub {ital V}} and for the Majorana case a single U(1) invariance that breaks down to the identity {ital open}1. In general the Schwinger-Dyson equation is not the same for both cases, since for Majorana fermions we have propagators of several types. However, in the particular case of a NJL {ital contact} interaction (for Majorana fermions this is {ital the} {ital only} {ital nonvanishing} {ital contact} {ital quartic}/{ital B} {ital interaction}), and with a convenient convention for the coupling, the Schwinger-Dyson equation turns out to have the same form for Dirac and for Majorana fermions. The bound-state boson spectrum is quite different in both cases: for the Dirac case, one has a spectrum {sup 2{ital S}+1}{ital L}{sub {ital J}}({ital S}=0,1) {ital J}{sup {ital P}{ital C}}=0{sup {minus}+},1{sup {minus}{minus}},0{sup ++},1{sup ++},1{sup +{minus}},2{sup ++},. . .

  6. Collective excitations in a superfluid of color-flavor locked quark matter

    SciTech Connect

    Fukushima, Kenji; Iida, Kei

    2005-04-01

    We investigate collective excitations coupled with baryon density in a system of massless three-flavor quarks in the collisionless regime. By using the Nambu-Jona-Lasinio (NJL) model in the mean-field approximation, we field-theoretically derive the spectra both for the normal and color-flavor locked (CFL) superfluid phases at zero temperature. In the normal phase, we obtain usual zero sound as a low-lying collective mode in the particle-hole (vector) channel. In the CFL phase, the nature of collective excitations varies in a way dependent on whether the excitation energy, {omega}, is larger or smaller than the threshold given by twice the pairing gap {delta}, at which pair excitations with nonzero total momentum become allowed to break up into two quasiparticles. For {omega}<<2{delta}, a phonon corresponding to fluctuations in the U(1) phase of {delta} appears as a sharp peak in the particle-particle ('H') channel. We reproduce the property known from low-energy effective theories that this mode propagates at a velocity of v{sub H}=1/{radical}(3) in the low momentum regime; the decay constant f{sub H} obtained in the NJL model is identical with the QCD result obtained in the mean-field approximation. We also find that, as the momentum of the phonon increases, the excitation energy goes up and asymptotically approaches {omega}=2{delta}. Above the threshold for pair excitations ({omega}>2{delta}), zero sound manifests itself in the vector channel. By locating the zero sound pole of the vector propagator in the complex energy plane, we investigate the attenuation and energy dispersion relation of zero sound. In the long wavelength limit, the phonon mode, the only low-lying excitation, has its spectral weight in the H channel alone, while the spectral function vanishes in the vector channel. This is due to nontrivial mixing between the H and vector channels in the superfluid medium. We finally extend our study to the case of nonzero temperature. We demonstrate how

  7. Heating (gapless) color-flavor locked quark matter

    SciTech Connect

    Fukushima, Kenji; Kouvaris, Chris; Rajagopal, Krishna

    2005-02-01

    We explore the phase diagram of neutral quark matter at high baryon density as a function of the temperature T and the strange quark mass M{sub s}. At T=0, there is a sharp distinction between the insulating color-flavor locked (CFL) phase, which occurs where M{sub s}{sup 2}/{mu}<2{delta}, and the metallic gapless CFL phase, which occurs at larger M{sub s}{sup 2}/{mu}. Here, {mu} is the chemical potential for quark number and {delta} is the gap in the CFL phase. We find this distinction blurred at T{ne}0, as the CFL phase undergoes an insulator to metal crossover when it is heated. We present an analytic treatment of this crossover. At higher temperatures, we map out the phase transition lines at which the gap parameters {delta}{sub 1}, {delta}{sub 2}, and {delta}{sub 3} describing ds pairing, us pairing and ud pairing, respectively, go to zero in an Nambu-Jona-Lasinio (NJL) model. For small values of M{sub s}{sup 2}/{mu}, we find that {delta}{sub 2} vanishes first, then {delta}{sub 1}, then {delta}{sub 3}. We find agreement with a previous Ginzburg-Landau analysis of the form of these transitions and find quantitative agreement with results obtained in full QCD at asymptotic density for ratios of coefficients in the Ginzburg-Landau potential. At larger M{sub s}{sup 2}/{mu}, we find that {delta}{sub 1} vanishes first, then {delta}{sub 2}, then {delta}{sub 3}. Hence, we find a ''doubly critical'' point in the (M{sub s}{sup 2}/{mu},T) plane at which two lines of second order phase transitions ({delta}{sub 1}{yields}0 and {delta}{sub 2}{yields}0) cross. Because we do not make any small-M{sub s} approximation, if we choose a relatively strong coupling leading to large gap parameters, we are able to pursue the analysis of the phase diagram all the way up to such large values of M{sub s} that there are no strange quarks present.

  8. Two-dimensional Fourier transform electronic spectroscopy at a conical intersection

    SciTech Connect

    Kitney-Hayes, Katherine A.; Ferro, Allison A.; Tiwari, Vivek; Jonas, David M.

    2014-03-28

    We report measurement and modeling of two-dimensional (2D) electronic spectra of a silicon naphthalocyanine (SiNc) in benzonitrile, a system for which the polarization anisotropy reveals passage through a square-symmetric Jahn-Teller conical intersection in ∼100 fs [D. A. Farrow, W. Qian, E. R. Smith, A. A. Ferro, and D. M. Jonas, J. Chem. Phys. 128, 144510 (2008)]. The measured 2D Fourier transform (FT) spectra indicate loss of electronic coherence on a similar timescale. The 2D spectra arising from femtosecond vibronic dynamics through the conical funnel are modeled by full non-adiabatic treatment of the coupled electronic and vibrational dynamics for a pair of un-damped Jahn-Teller active vibrations responsible for both electronic decoherence and population transfer. Additional damped Jahn-Teller active modes that can cause only decoherence or population transfer are treated with analytical response functions that can be incorporated into the numerical non-adiabatic calculation by exploiting symmetry assignment of degenerate vibronic eigenstates to one of two electronic states. Franck-Condon active totally symmetric modes are incorporated analytically. The calculations reveal that these conical intersection dynamics alone are incapable of destroying the coherence of the initially prepared wavepacket on the experimentally observed timescale and predict an unobserved recurrence in the photon echo slice at ∼200 fs. Agreement with the experimental two-dimensional electronic spectra necessitates a role for totally symmetric vibrational dynamics in causing the echo slice to decay on a ∼100 fs timescale. This extended model also reproduces the ∼100 fs ultrafast electronic anisotropy decay in SiNc when an “asymmetric solvation mode” with a small stabilization energy of ∼2 cm{sup −1} is included. Although calculations show that inhomogeneities in the energy gap between excited states can broaden the anti-diagonal 2D lineshape, the anti-diagonal width is

  9. HYBRID STARS IN THE LIGHT OF THE MASSIVE PULSAR PSR J1614-2230

    SciTech Connect

    Lenzi, C. H.; Lugones, G. E-mail: german.lugones@ufabc.edu.br

    2012-11-01

    We perform a systematic study of hybrid star configurations using several parameterizations of a relativistic mean-field hadronic equation of state (EoS) and the Nambu-Jona-Lasinio (NJL) model for three-flavor quark matter. For the hadronic phase we use the stiff GM1 and TM1 parameterizations, as well as the very stiff NL3 model. In the NJL Lagrangian we include scalar, vector, and 't Hooft interactions. The vector coupling constant g{sub v} is treated as a free parameter. We also consider that there is a split between the deconfinement and the chiral phase transitions which is controlled by changing the conventional value of the vacuum pressure -{Omega}{sub 0} in the NJL thermodynamic potential by -({Omega}{sub 0} + {delta}{Omega}{sub 0}), with {delta}{Omega}{sub 0} a free parameter. We find that, as we increase the value of {delta}{Omega}{sub 0}, hybrid stars have a larger maximum mass but are less stable, i.e., hybrid configurations are stable within a smaller range of central densities. For large enough {delta}{Omega}{sub 0}, stable hybrid configurations are not possible at all. The effect of increasing the coupling constant g{sub v} is very similar. We show that stable hybrid configurations with a maximum mass larger than the observed mass of the pulsar PSR J1614-2230 are possible for a large region of the parameter space of g{sub v} and {delta}{Omega}{sub 0} provided the hadronic EoS contains nucleons only. When the baryon octet is included in the hadronic phase, only a very small region of the parameter space allows an explanation of the mass of PSR J1614-2230. We compare our results with previous calculations of hybrid stars within the NJL model. We show that it is possible to obtain stable hybrid configurations also in the case {delta}{Omega}{sub 0} = 0 that corresponds to the conventional NJL model for which the pressure and density vanish at zero temperature and chemical potential.

  10. Missed connections: A case study of the social networks of physics doctoral students in a single department

    NASA Astrophysics Data System (ADS)

    Knaub, Alexis Victoria

    research decreases the time to degree. Only research peer network and departmental information network variables remain in this model. Suggestions for further research for both physics/STEM education and social network analysis are included. Suggestions for ways in which the Jonas University physics department can improve its climate are also included. Although these suggestions are written based upon the Jonas University data, they may be applicable to other physics/STEM graduate programs.

  11. Communicating climate change: alerting versus stimulating action, a few "philosophical" interrogations from a marine biogeochemist

    NASA Astrophysics Data System (ADS)

    Ragueneau, O.

    2009-04-01

    can come to calculate their own emissions and then, replace them in a more global context. During the debates then, very rapidly, politics and ethics come into play. Beyond the question raised above concerning outreach versus engagement, I find it VERY DIFFICULT to find the right balance between alerting and stimulating action. On one hand, we need to alert on the reality of the numbers given (and it is hard to reduce our personal emissions by a factor of 4 in France or 10 in the US), the ethical problems they raise (we, in developed countries, are responsible for the majority of past CO2 emissions and we should do the major effort, Ragueneau et al., 2008). And on the other hand, we need to remain optimistic and show that solutions do exist, if we do not want to discourage people to act. There is debate between the ethics of fear (H. Jonas) and the ethics of hope (E. Morin) as best ways to stimulate action and I feel we need to share our experiences on how best navigate between these two lines. So I would be very happy to participate in such a session to discuss the role of scientists in essential issues such as societal debates related to climate change, the frontier between outreach and political engagement, and the attitude needed to convince that there is a problem, that this problem is big and we need to stress it, but that it can be addressed with very positive implications for each of us.

  12. Reconstruction of 3d grain boundaries from rock thin sections, using polarised light

    NASA Astrophysics Data System (ADS)

    Markus Hammes, Daniel; Peternell, Mark

    2016-04-01

    Grain boundaries affect the physical and chemical properties of polycrystalline materials significantly by initiating reactions and collecting impurities (Birchenall, 1959), and play an essential role in recrystallization (Doherty et al. 1997). In particular, the shape and crystallographic orientation of grain boundaries reveal the deformation and annealing history of rocks (Kruhl and Peternell 2002, Kuntcheva et al. 2006). However, there is a lack of non-destructive and easy-to-use computer supported methods to determine grain boundary geometries in 3D. The only available instrument using optical light to measure grain boundary angles is still the polarising microscope with attached universal stage; operated manually and time-consuming in use. Here we present a new approach to determine 3d grain boundary orientations from 2D rock thin sections. The data is recorded by using an automatic fabric analyser microscope (Peternell et al., 2010). Due to its unique arrangement of 9 light directions the highest birefringence colour due to each light direction and crystal orientation (retardation) can be determined at each pixel in the field of view. Retardation profiles across grain boundaries enable the calculation of grain boundary angle and direction. The data for all positions separating the grains are combined and further processed. In combination with the lateral position of the grain boundary, acquired using the FAME software (Hammes and Peternell, in review), the data is used to reconstruct a 3d grain boundary model. The processing of data is almost fully automatic by using MATLAB®. Only minor manual input is required. The applicability was demonstrated on quartzite samples, but the method is not solely restricted on quartz grains and other birefringent polycrystalline materials could be used instead. References: Birchenall, C.E., 1959: Physical Metallurgy. McGraw-Hill, New York. Doherty, R.D., Hughes, D.A., Humphreys, F.J., Jonas, J.J., Juul Jensen, D., Kassner, M

  13. Universal scaling of grain size distributions during dislocation creep

    NASA Astrophysics Data System (ADS)

    Aupart, Claire; Dunkel, Kristina G.; Angheluta, Luiza; Austrheim, Håkon; Ildefonse, Benoît; Malthe-Sørenssen, Anders; Jamtveit, Bjørn

    2017-04-01

    Recrystallization: Can It Result in Major Theological Weakening? » International Journal of Earth Sciences 90 (1): 28-45. Doherty, R. D., D. A. Hughes, F. J. Humphreys, J. J. Jonas, D. J. Jensen, M. E. Kassner, W. E. King, T. R. McNelley, H. J. McQueen, and A. D. Rollett. 1997. « Current Issues in Recrystallization: A Review ». Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing 238 (2): 219-74. doi:10.1016/S0921-5093(97)00424-3. Jung, H., and S. I. Karato. 2001. « Effects of Water on Dynamically Recrystallized Grain-Size of Olivine ». Journal of Structural Geology 23 (9): 1337-44. doi:10.1016/S0191-8141(01)00005-0. Linckens, J., G. Zulauf, and J. Hammer. 2016. « Experimental Deformation of Coarse-Grained Rock Salt to High Strain ». Journal of Geophysical Research-Solid Earth 121 (8): 6150-71. doi:10.1002/2016JB012890. Platt, J.P., and W.M. Behr. 2011. « Grainsize Evolution in Ductile Shear Zones: Implications for Strain Localization and the Strength of the Lithosphere ». Journal of Structural Geology 33 (4): 537-50. doi:10.1016/j.jsg.2011.01.018.

  14. EDITORIAL: Focus on Nanostructured Soft Matter

    NASA Astrophysics Data System (ADS)

    Reineker, Peter; Schülz, Michael

    2004-01-01

    Nanostructures in general are playing a more and more important role in the physics and chemistry of condensed matter systems including both hard and soft materials. This Focus Issue concentrates particularly on recent developments in Nanostructured Soft Matter Systems. Many interesting questions related to both fundamental and applied research in this field have arisen. Some of them are connected to the chemical reactions that take place during the irreversible formation of soft matter systems. Others refer to the theoretical and experimental investigations of structures and topologies of `nanostructured soft matter', e.g. heterogeneous polymers and polymer networks, or soft matter at low dimensions or in constrained geometries. Additional research has also been devoted to the dynamics of other complex nanostructured systems, such as the structure formation on the basis of polymer systems and polyelectrolytes, and several kinds of phase transitions on nano- and microscales. The contributions collected here present the most up-to-date research results on all of these topics. New Journal of Physics, as an electronic journal, is perfectly suited for the presentation of the complex results that the experimental and theoretical investigations reported here yield. The articles that will follow provide a number of excellent examples of the use of animations, movies and colour features for the added benefit of the reader. Focus on Nanostructured Soft Matter Contents Phase separation kinetics in compressible polymer solutions: computer simulation of the early stages Peter Virnau, Marcus Müller, Luis González MacDowell and Kurt Binder Spectral dynamics in the B800 band of LH2 from Rhodospirillum molischianum: a single-molecule study Clemens Hofmann, Thijs J Aartsma, Hartmut Michel and Jürgen Köhler Adsorption of polyacrylic acid on self-assembled monolayers investigated by single-molecule force spectroscopy Claudia Friedsam, Aránzazu Del Campo Bécares, Ulrich Jonas

  15. Quantum Chromodynamics and Color Confinement (confinement 2000) - Proceedings of the International Symposium

    NASA Astrophysics Data System (ADS)

    Suganuma, H.; Fukushima, M.; Toki, H.

    -diagonal Gluon Phase in the Maximally Abelian Gauge * On the Colour Confinement and the Minimal Surface * Glueball Mass and String Tension of SU(2) Gluodynamics from Abelian Monopoles and Strings * Application of the Non-Perturbative Renormalization Group to the Nambu-Jona-Lasinio Model at Finite Temperature and Density * Confining Flux-Tube and Hadrons in QCD * Gauge Symmetry Breakdown due to Dynamical Higgs Scalar * Spatial Structure of Quark Cooper Pairs * New Approach to Axial Coupling Constants in the QCD Sum Rule and Instanton Effects * String Breaking on a Lattice * Bethe-Salpeter Approach for Mesons within the Dual Ginzburg-Landau Theory * Gauge Dependence and Matching Procedure of a Nonrelativistic QCD Boundstate Formalism * A Mathematical Approach to the SU(2)-Quark Confinement * Simulations of Odd Flavors QCD by Hybrid Monte Carlo * Non-Perturbative Renormalization Group Analysis of Dynamical Chiral Symmetry Breaking with Beyond Ladder Contributions * Charmonium Physics in Finite Temperature Lattice QCD * From Meson-Nucleon Scattering to Vector Mesons in Nuclear Matter * Symposium Program * List of Participants

  16. In situ soil moisture and matrix potential - what do we measure?

    NASA Astrophysics Data System (ADS)

    Jackisch, Conrad; Durner, Wolfgang

    2017-04-01

    poses quite some concern about deriving field parameters from lab measurements. We will present some insights from the comparison study and highlight the conceptual concerns arising from it. Through this we hope to stimulate a discussion towards more critical revision of measurement assumptions and towards the development of alternative techniques to monitor subsurface states. The sensor comparison study consortium is a cooperation of Wolfgang Durner2, Ines Andrä2, Kai Germer2, Katrin Schulz2, Marcus Schiedung2, Jaqueline Haller-Jans2, Jonas Schneider2, Julia Jaquemotte2, Philipp Helmer2, Leander Lotz2, Thomas Graeff3, Andreas Bauer3, Irene Hahn3, Conrad Jackisch1, Martin Sanda4, Monika Kumpan5, Johann Dorner5, Gerrit de Rooij6, Stephan Wessel-Bothe7, Lorenz Kottmann8, and Siegfried Schittenhelm8. The great support by the team and the Thünen Institute Braunschweig is gratefully acknowledged. 1 Karlsruhe Institute of Technology, 2 Technical University of Braunschweig, 3 University of Potsdam, 4 Technical University of Prague, 5 Federal Department for Water Management Petzenkirchen, 6 Helmholtz Centre for Environmental Research Halle, 7 ecoTech GmbH Bonn, 8 Julius Kühn Institute Braunschweig

  17. 2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.

    PubMed

    2012-04-01

    Third Edition [Formula: see text] [Box: see text] Printed with permission from the International Society for Biological and Environmental Repositories (ISBER) © 2011 ISBER All Rights Reserved Editor-in-Chief Lori D. Campbell, PhD Associate Editors Fay Betsou, PhD Debra Leiolani Garcia, MPA Judith G. Giri, PhD Karen E. Pitt, PhD Rebecca S. Pugh, MS Katherine C. Sexton, MBA Amy P.N. Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use. Sharing successful strategies for accomplishing this goal is one of the driving forces for the International Society for Biological and Environmental Repositories (ISBER). For more information about ISBER see www.isber.org . ISBER's Best Practices for Repositories (Best Practices) reflect the collective experience of its members and has received broad input from other repository professionals. Throughout this document

  18. 12th WINFOCUS world congress on ultrasound in emergency and critical care.

    PubMed

    Acar, Yahya; Tezel, Onur; Salman, Necati; Cevik, Erdem; Algaba-Montes, Margarita; Oviedo-García, Alberto; Patricio-Bordomás, Mayra; Mahmoud, Mustafa Z; Sulieman, Abdelmoneim; Ali, Abbas; Mustafa, Alrayah; Abdelrahman, Ihab; Bahar, Mustafa; Ali, Osama; Lester Kirchner, H; Prosen, Gregor; Anzic, Ajda; Leeson, Paul; Bahreini, Maryam; Rasooli, Fatemeh; Hosseinnejad, Houman; Blecher, Gabriel; Meek, Robert; Egerton-Warburton, Diana; Ćuti, Edina Ćatić; Belina, Stanko; Vančina, Tihomir; Kovačević, Idriz; Rustemović, Nadan; Chang, Ikwan; Lee, Jin Hee; Kwak, Young Ho; Kim, Do Kyun; Cheng, Chi-Yung; Pan, Hsiu-Yung; Kung, Chia-Te; Ćurčić, Ela; Pritišanac, Ena; Planinc, Ivo; Medić, Marijana Grgić; Radonić, Radovan; Fasina, Abiola; Dean, Anthony J; Panebianco, Nova L; Henwood, Patricia S; Fochi, Oliviero; Favarato, Moreno; Bonanomi, Ezio; Tomić, Ivan; Ha, Youngrock; Toh, Hongchuen; Harmon, Elizabeth; Chan, Wilma; Baston, Cameron; Morrison, Gail; Shofer, Frances; Hua, Angela; Kim, Sharon; Tsung, James; Gunaydin, Isa; Kekec, Zeynep; Ay, Mehmet Oguzhan; Kim, Jinjoo; Kim, Jinhyun; Choi, Gyoosung; Shim, Dowon; Lee, Ji-Han; Ambrozic, Jana; Prokselj, Katja; Lucovnik, Miha; Simenc, Gabrijela Brzan; Mačiulienė, Asta; Maleckas, Almantas; Kriščiukaitis, Algimantas; Mačiulis, Vytautas; Macas, Andrius; Mohite, Sharad; Narancsik, Zoltan; Možina, Hugon; Nikolić, Sara; Hansel, Jan; Petrovčič, Rok; Mršić, Una; Orlob, Simon; Lerchbaumer, Markus; Schönegger, Niklas; Kaufmann, Reinhard; Pan, Chun-I; Wu, Chien-Hung; Pasquale, Sarah; Doniger, Stephanie J; Yellin, Sharon; Chiricolo, Gerardo; Potisek, Maja; Drnovšek, Borut; Leskovar, Boštjan; Robinson, Kristine; Kraft, Clara; Moser, Benjamin; Davis, Stephen; Layman, Shelley; Sayeed, Yusef; Minardi, Joseph; Pasic, Irmina Sefic; Dzananovic, Amra; Pasic, Anes; Zubovic, Sandra Vegar; Hauptman, Ana Godan; Brajkovic, Ana Vujaklija; Babel, Jaksa; Peklic, Marina; Radonic, Vedran; Bielen, Luka; Ming, Peh Wee; Yezid, Nur Hafiza; Mohammed, Fatahul Laham; Huda, Zainal Abidin; Ismail, Wan Nasarudin Wan; Isa, W Yus Haniff W; Fauzi, Hashairi; Seeva, Praveena; Mazlan, Mohd Zulfakar

    2016-09-01

    Jinjoo Kim, Jinhyun Kim, Gyoosung Choi, Dowon ShimA27 Usefulness of abdominal ultrasound for acute pyelonephritis diagnosis after kidney transplantationJi-Han LeeA28 Lung ultrasound for assessing fluid tolerance in severe preeclampsiaJana Ambrozic, Katja Prokselj, Miha LucovnikA29 Optic nerve sheath ultrasound in severe preeclampsiaGabrijela Brzan Simenc, Jana Ambrozic, Miha LucovnikA30 Focused echocardiography monitoring in the postoperative period for non-cardiac patientsAsta Mačiulienė, Almantas Maleckas, Algimantas Kriščiukaitis, Vytautas Mačiulis, Andrius MacasA31 POCUS-guided paediatric upper limb fracture reduction: algorithm, tricks, and tipsSharad MohiteA32 Point-of-care lung ultrasound: a good diagnostic tool for pneumonia in a septic patientZoltan Narancsik, Hugon MožinaA33 A case of undergraduate POCUS (r)evolutionSara Nikolić, Jan Hansel, Rok Petrovčič, Una Mršić, Gregor ProsenA34 The Graz Summer School for ultrasound: from first contact to bedside application: three-and-a-half-day undergraduate ultrasound training: résumé after two years of continuous developmentSimon Orlob, Markus Lerchbaumer, Niklas Schönegger, Reinhard KaufmannA35 Usefulness of point-of-care ultrasound in the emergency room in a patient with acute abdominal painAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA36 Use of bedside ultrasound in a critically ill patient. A case reportAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA37 Diagnostic yield of clinical echocardiography for the emergency physicianAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA38 Focused cardiac ultrasound in early diagnosis of type A aortic dissection with atypical presentationChun-I Pan, Hsiu-Yung Pan, Chien-Hung WuA39 Detection of imperforated hymen by point-of-care ultrasoundHsiu-yung Pan, Chia-Te KungA40 Developing a point-of-care ultrasound curriculum for pediatric nurse practitioners practicing in the pediatric emergency

  19. Annotated type catalogue of the Bulimulidae (Mollusca, Gastropoda, Orthalicoidea) in the Natural History Museum, London

    PubMed Central

    Breure, Abraham S.H.; Ablett, Jonathan D.

    2014-01-01

    , 1909; Bulimus (Otostomus) napo Angas, 1878; Drymaeus notabilis da Costa, 1906; Drymaeus notatus da Costa, 1906; Bulimulus (Drymaeus) nubilus Preston, 1903; Drymaeus obliquistriatus da Costa, 1901; Bulimus (Drymaeus) ochrocheilus E.A. Smith, 1877; Bulimus (Drymaeus) orthostoma E.A. Smith, 1877; Drymaeus expansus perenensis da Costa, 1901; Bulimulus pergracilis Rolle, 1904; Bulimulus (Drymaeus) plicatoliratus da Costa, 1898; Drymaeus prestoni da Costa, 1906; Drymaeus punctatus da Costa, 1907; Bulimus (Leptomerus) sanctaeluciae E.A. Smith, 1889; Bulimulus (Drymaeus) selli Preston, 1909; Drymaeus subventricosus da Costa, 1901; Bulimulus (Drymaeus) tigrinus da Costa, 1898; Drymaeus volsus Fulton, 1907; Drymaeus wintlei Finch, 1929; Bulimus zhorquinensis Angas, 1879; Bulimulus (Drymaeus) ziczac da Costa, 1898. The following junior subjective synonyms are established: Bulimus antioquensis Pfeiffer, 1855 = Bulimus baranguillanus Pfeiffer, 1853; Drymaeus bellus da Costa, 1906 = Drymaeus blandi Pilsbry, 1897; Bulimus hachensis Reeve 1850 = Bulimus gruneri Pfeiffer, 1846 = Bulimus columbianus Lea, 1838; Bulimus (Otostomus) lamas Higgins 1868 = Bulimus trujillensis Philippi, 1867; Bulimulus (Drymaeus) binominis lascellianus E.A. Smith, 1895 = Bulimulus (Drymaeus) binominis E.A. Smith, 1895; Drymaeus multispira da Costa, 1904 = Helix torallyi d’Orbigny, 1835; Bulimulus (Drymaeus) plicatoliratus Da Costa, 1898 = Bulimus convexus Pfeiffer, 1855; Bulimus sugillatus Pfeiffer, 1857 = Bulimus rivasii d’Orbigny, 1837; Bulimus meridionalis Reeve 1848 [June] = Bulimus voithianus Pfeiffer, 1847. New combinations are: Bostryx montagnei (d’Orbigny, 1837); Bostryx obliquiportus (da Costa, 1901); Bulimulus heloicus (d’Orbigny, 1835); Drymaeus (Drymaeus) lusorius (Pfeiffer, 1855); Drymaeus (Drymaeus) trigonostomus (Jonas, 1844); Drymaeus (Drymaeus) wintlei Finch, 1929; Drymaeus (Mesembrinus) conicus da Costa, 1907; Kuschelenia (Kuschelenia) culminea culminea (d’Orbigny, 1835

  20. Geology and ground-water resources of Washington, D.C., and vicinity

    USGS Publications Warehouse

    Johnston, Paul McKelvey

    1964-01-01

    The area of this report includes 436 square miles centered about the District of Columbia. The area contains parts of two distinctly different physiographic provinces-the Piedmont and the Coastal Plain. The Fall Line, which separates the Piedmont province on the west from the Coastal Plain Province on the east, bisects the area diagonally from northeast to southwest. Northwest of the Fall Line, deeply weathered igneous and metamorphic rocks are exposed ; to the southeast, these rocks are covered by Coastal Plain sediments; the nonconformity between crystalline rock and sediments dips southeast at an average rate of about 125 feet per mile. The rocks of the Piedmont include: (1) schist, phyllite, and quartzite of the Wissahickon Formation; (2) altered mafic rocks such as greenstone and serpentine; (3) the Laurel Gneiss of Chapman, 1942, and the Sykesville Formation of Jonas, 1928--both probably derived from the Wissahickon ; and (4) later granitic intrusive rocks. Lying upon this basement of hard rocks east of the Fall Line are the generally unconsolidated sediments of the Coastal Plain, which include gravel, sand, and clay, ranging in age from Cretaceous to Recent. These sediments measure only a few inches at their western extremity but thicken to 1,800 feet at the southeast corner of the mapped area. Owing to the great diversity in the geology of the two provinces, the waterbearing characteristics of the rocks also vary greatly. In the Piedmont, ground water occurs under unconfined or water-table conditions in openings and fissures in the hard rocks or in the residual weathered blanket that overlies them. In the Coastal Plain, the shallow wells tap unconfined water, but beneath the upper clay layers the water is contained in the sand and gravel under artesian pressure and must be recovered by deep drilled wells. Wells are of three types--drilled, bored, and dug. Drilled wells furnish a permanent water supply and are the least subject to pollution when properly