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Sample records for jonas vilys vytautas

  1. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Kollisch-Singule, Michaela; Andrews, Penny L; Aiash, Hani; Habashi, Nader M; Gatto, Louis A

    2017-04-06

    The acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation. However, mechanical ventilation can be a double edge sword, if set improperly can exacerbate the tissue damage caused by ARDS and is known as ventilator induced lung injury (VILI). In order to minimize VILI we must understand the pathophysiologic mechanisms of tissue damage at the alveolar level. In this Physiology in Medicine paper the dynamic physiology of alveolar inflation and deflation during mechanical ventilation will be reviewed. In addition, the pathophysiologic mechanisms of VILI will be reviewed and this knowledge used to suggest an optimal mechanical breath profile (MBP - all airway pressures, volumes, flows, rates and the duration that they are applied at both inspiration and expiration) necessary to minimize VILI. Our review suggests that the current protective ventilation strategy known as the 'Open Lung Strategy' would be the optimal lung protective approach. However, the viscoelastic behavior of dynamic alveolar inflation and deflation has not yet been incorporated into protective mechanical ventilation strategies. Using our knowledge of dynamic alveolar mechanics (i.e the dynamic change in alveolar and alveolar duct size and shape during tidal ventilation) to modify the MBP necessary to minimize VILI will reduce the morbidity and mortality associated with ARDS.

  2. Determinants of Cervical Cancer Screening Accuracy for Visual Inspection with Acetic Acid (VIA) and Lugol’s Iodine (VILI) Performed by Nurse and Physician

    PubMed Central

    Raifu, Amidu O.; El-Zein, Mariam; Sangwa-Lugoma, Ghislain; Ramanakumar, Agnihotram; Walter, Stephen D.

    2017-01-01

    Background Visual inspection with acetic acid (VIA) and Lugol’s iodine (VILI) are used to screen women for cervical cancer in low-resource settings. Little is known about correlates of their diagnostic accuracy by healthcare provider. We examined determinants of VIA and VILI screening accuracy by examiner in a cross-sectional screening study of 1528 women aged 30 years or older in a suburb of Kinshasa, Democratic Republic of Congo. Methods We used a logistic regression model for sensitivity and specificity to estimate the diagnostic accuracy of VIA and VILI, independently performed by nurse and physician, as a function of sociodemographic and reproductive health characteristics. Results Nurses rated tests as positive more often than physicians (36.3% vs 30.2% for VIA, 26.2% vs 25.2% for VILI). Women’s age was the most important determinant of performance. It was inversely associated with sensitivity (nurse’s VIA: p<0.001, nurse’s VILI: p = 0.018, physician’s VIA: p = 0.005, physician’s VILI: p = 0.006) but positively associated with specificity (all four combinations: p<0.001). Increasing parity adversely affected sensitivity and specificity, but the effects on sensitivity were significant for nurses only. The screening performance of physician’s assessment was significantly better than the nurse’s (difference in sensitivity: VIA = 13%, VILI = 16%; difference in specificity: VIA = 6%, VILI = 1%). Conclusions Age and parity influence the performance of visual tests for cervical cancer screening. Proper training of local healthcare providers in the conduct of these tests should take into account these factors for improved performance of VIA and VILI in detecting cervical precancerous lesions among women in limited-resource settings. PMID:28107486

  3. Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI).

    PubMed

    Nieman, Gary F; Satalin, Joshua; Andrews, Penny; Habashi, Nader M; Gatto, Louis A

    2016-12-01

    It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is a critical need to develop novel ventilation strategies that will protect the lung and reduce ARDS mortality. Protti et al. have begun to analyze the impact of mechanical ventilation on lung tissue using engineering methods in normal pigs ventilated for 54 h. They used these methods to assess the impact of a mechanical breath on dynamic and static global lung strain and energy load. Strain is the change in lung volume in response to an applied stress (i.e., Tidal Volume-Vt). This study has yielded a number of exciting new concepts including the following: (1) Individual mechanical breath parameters (e.g., Vt or Plateau Pressure) are not directly correlated with VILI but rather any combination of parameters that subject the lung to excessive dynamic strain and energy/power load will cause VILI; (2) all strain is not equal; dynamic strain resulting in a dynamic energy load (i.e., kinetic energy) is more damaging to lung tissue than static strain and energy load (i.e., potential energy); and (3) a critical consideration is not just the size of the Vt but the size of the lung that is being ventilated by this Vt. This key concept merits attention since our current protective ventilation strategies are fixated on the priority of keeping the Vt low. If the lung is fully inflated, a large Vt is not necessarily injurious. In conclusion, using engineering concepts to analyze the impact of the mechanical breath on the lung is a novel new approach to investigate VILI mechanisms and to help design the optimally protective breath. Data generated using these methods have challenged some of the current dogma surrounding the mechanisms of VILI and of the components in the mechanical breath necessary for lung protection.

  4. Nambu-Jona-Lasinio theory and dynamical breaking of supersymmetry

    NASA Astrophysics Data System (ADS)

    Maru, Nobuhito

    2016-06-01

    A recently proposed new mechanism of D-term-triggered dynamical supersymmetry breaking is reviewed. Supersymmetry is dynamically broken by a nonvanishing D-term vacuum expectation value, which is realized as a nontrivial solution of the gap equation in the self-consistent approximation, as in the case of the Nambu-Jona-Lasinio model and BCS superconductivity.

  5. Intersecting branes and Nambu-Jona-Lasinio model

    SciTech Connect

    Dhar, Avinash; Nag, Partha

    2009-06-15

    We discuss chiral symmetry breaking in the intersecting brane model of Sakai and Sugimoto at weak coupling for a generic value of separation L between the flavor D8 and anti-D8-branes. For any finite value of the radius R of the circle around which the color D4-branes wrap, a nonlocal Nambu-Jona-Lasinio-type short-range interaction couples the flavor branes and antibranes. We argue that chiral symmetry is broken in this model only above a certain critical value of the four-dimensional 't Hooft coupling and confirm this through numerical calculations of solutions to the gap equation. We also numerically investigate chiral symmetry breaking in the limit R{yields}{infinity} keeping L fixed, but find that simple ways of implementing this limit do not lead to a consistent picture of chiral symmetry breaking in the noncompact version of the nonlocal Nambu-Jona-Lasinio model.

  6. Polyakov-Nambu-Jona-Lasinio model in finite volumes

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Abhijit; Ghosh, Sanjay K.; Ray, Rajarshi; Saha, Kinkar; Upadhaya, Sudipa

    2016-12-01

    We discuss the 2+1 flavor Polyakov loop enhanced Nambu-Jona-Lasinio model in a finite volume. The main objective is to check the volume scaling of thermodynamic observables for various temperatures and chemical potentials. We observe the possible violation of the scaling with system size in a considerable window along the whole transition region in the T\\text-μq plane.

  7. Reparametrizing the Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Abhijit; Ghosh, Sanjay K.; Maity, Soumitra; Raha, Sibaji; Ray, Rajarshi; Saha, Kinkar; Upadhaya, Sudipa

    2017-03-01

    The Polyakov-Nambu-Jona-Lasinio model has been quite successful in describing various qualitative features of observables for strongly interacting matter, that are measurable in heavy-ion collision experiments. The question still remains on the quantitative uncertainties in the model results. Such an estimation is possible only by contrasting these results with those obtained from first principles using the lattice QCD framework. Recently a variety of lattice QCD data were reported in the realistic continuum limit. Here we make a first attempt at reparametrizing the model so as to reproduce these lattice data. We find excellent quantitative agreement for the equation of state. Certain discrepancies in the charge and strangeness susceptibilities as well as baryon-charge correlation still remain. We discuss their causes and outline possible directions to remove them.

  8. Test characteristics of visual inspection with 4% acetic acid (VIA) and Lugol's iodine (VILI) in cervical cancer screening in Kerala, India.

    PubMed

    Sankaranarayanan, Rengaswamy; Wesley, Ramani; Thara, Somanathan; Dhakad, Namrata; Chandralekha, Bharathykutty; Sebastian, Paul; Chithrathara, K; Parkin, Donald Maxwell; Nair, Madhavan Krishnan

    2003-09-01

    Simple and inexpensive methods based on visual examination of the cervix are currently being investigated as alternative methods of cervical screening. The test characteristics of visual inspection with 4% acetic acid (VIA), and Lugol's iodine (VILI) and conventional cytology were investigated in a cross-sectional study involving 4,444 women aged 25 to 65 years in Kerala, India. While detection of any acetowhite area constituted a low-threshold positive VIA, detection of well-defined, opaque acetowhite lesions close to or touching the squamocolumnar junction constituted a high-threshold positive VIA test. Detection of definite yellow iodine nonuptake areas in the transformation zone close to or touching the squamocolumnar junction constituted a positive VILI test. Cytology was considered positive if reported as atypia or worse lesions. All screened women were evaluated by colposcopy and biopsies were directed in 1,644 women (37.0%), which allowed the direct estimation of sensitivity, specificity and predictive values. The reference diagnosis was based on a combination of histology and/or colposcopy. True disease status was defined as CIN 2 and worse lesions. A total of 149 (3.4%) women had CIN 2 or worse lesions. The sensitivities of low-threshold VIA, high-threshold VIA, VILI and cytology to detect CIN 2 or worse disease were 88.6%, 82.6%, 87.2% and 81.9%, respectively; the corresponding specificities were 78.0%, 86.5%, 84.7% and 87.8%. Our results indicate that VIA and VILI are suitable alternate screening tests to cytology for detecting cervical neoplasia in low-resource settings.

  9. Gluon fragmentation functions in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Yang, Dong-Jing; Li, Hsiang-nan

    2016-09-01

    We derive gluon fragmentation functions in the Nambu-Jona-Lasinio (NJL) model by treating a gluon as a pair of color lines formed by a fictitious quark and antiquark (q q ¯). Gluon elementary fragmentation functions are obtained from the quark and antiquark elementary fragmentation functions for emitting specific mesons in the NJL model under the requirement that the q q ¯ pair maintains in the flavor-singlet state after meson emissions. An integral equation, which iterates the gluon elementary fragmentation functions to all orders, is then solved to yield the gluon fragmentation functions at a model scale. It is observed that these solutions are stable with respect to variation of relevant model parameters, especially after QCD evolution to a higher scale is implemented. We show that the inclusion of the gluon fragmentation functions into the theoretical predictions from only the quark fragmentation functions greatly improves the agreement with the SLD data for the pion and kaon productions in e+e- annihilation. Our proposal provides a plausible construct for the gluon fragmentation functions, which are supposed to be null in the NJL model.

  10. Gluon Fragmentation Functions in the Nambu-Jona-Lasinio Model

    NASA Astrophysics Data System (ADS)

    Yang, Dong-Jing; Li, Hsiang-nan

    We derive gluon fragmentation functions in the Nambu-Jona-Lasinio (NJL) model by approximating a gluon as a fictitious color-octet quark-anti-quark (qbar{q}) pair. Gluon elementary fragmentation functions are derived from the quark and anti-quark elementary fragmentation functions for emitting specific mesons in the NJL model under the requirement that the qbar{q} pair maintains in the flavor-singlet state after meson emission. An iteration method and an inverse matrix method based on the gluon elementary fragmentation functions then yield the gluon fragmentation functions at the model scale. It is found that the resultant gluon fragmentation functions are stable with respect to variation of relevant model parameters, especially after QCD evolution to a higher scale is implemented. We show that the inclusion of the gluon fragmentation functions into the theoretical predictions from only the quark fragmentation functions greatly improve the agreement with the SLD data for the pion and kaon productions in e+e- annihilation. Our proposal provides a plausible construct for the gluon fragmentation functions, which are supposed to be null in the NJL model.

  11. Mesonic states in the generalised Nambu-Jona-Lasinio theories

    NASA Astrophysics Data System (ADS)

    Nefediev, A. V.; Ribeiro, J. E. F. T.

    2005-04-01

    For any Nambu-Jona-Lasinio model of QCD with arbitrary nonlocal, instantaneous, quark current-current confining kernels, we use a generalised Bogoliubov technique to go beyond BCS level (in the large-NC limit) so as to explicitly build quark-antiquark compound operators for creating/annihilating mesons. In the Hamiltonian approach, the mesonic bound-state equations appear (from the generalised Bogoliubov transformation) as mass-gap-like equations which, in turn, ensure the absence, in the Hamiltonian, of mesonic Bogoliubov anomalous terms. We go further to demonstrate the one-to-one correspondence between Hamiltonian and Bethe-Salpeter approaches to non-local NJL-type models for QCD and give the corresponding "dictionary" necessary to "translate" the amplitudes built using the graphical Feynman rules to the terms of the Hamiltonian, and vice versa. We comment on the problem of multiple vacua existence in such type of models and argue that mesonic states in the theory should be prescribed to have an extra index — the index of the replica in which they are created. Then the completely diagonalised Hamiltonian should contain a sum over this new index. The method is proved to be general and valid for any instantaneous quark kernel.

  12. Nonet meson properties in the Nambu-Jona-Lasinio model with dimensional versus cutoff regularization

    SciTech Connect

    Inagaki, T.; Kimura, D.; Kohyama, H.; Kvinikhidze, A.

    2011-02-01

    The Nambu-Jona-Lasinio model with a Kobayashi-Maskawa-'t Hooft term is one low energy effective theory of QCD which includes the U{sub A}(1) anomaly. We investigate nonet meson properties in this model with three flavors of quarks. We employ two types of regularizations, the dimensional and sharp cutoff ones. The model parameters are fixed phenomenologically for each regularization. Evaluating the kaon decay constant, the {eta} meson mass and the topological susceptibility, we show the regularization dependence of the results and discuss the applicability of the Nambu-Jona-Lasinio model.

  13. Emergence of a nonuniform pion condensate in the (1 + 1)-dimensional Nambu-Jona-Lasinio model

    SciTech Connect

    Gubina, N. V. Zhukovsky, V. Ch.; Klimenko, K. G.; Kurbanov, S. G.

    2013-11-15

    The (1 + 1)-dimensional Nambu-Jona-Lasinio model describing the system of two-flavor quarks is studied in the limit of a large number of colors in the presence of a baryon chemical potential Micro-Sign and an isospin chemical potential Micro-Sign {sub I}. The possible formation of a nonuniform pion condensate in dense quark matter is considered for the cases of both the massive and the massless model.

  14. Natural law Judaism? The genesis of bioethics in Hans Jonas, Leo Strauss, and Leon Kass.

    PubMed

    Vogel, Lawrence

    2006-01-01

    Leon Kass is much misunderstood. He is not simply a Republican ideologue who tailored his ideas to break out of the ivory tower and into the halls of power. Nor does he look simply to use human nature as a moral guide. When the full range of his writings is considered and set in the tradition of his teachers, Hans Jonas and Leo Strauss, what emerges is a natural law position colored by religious revelation.

  15. Scalar-pseudoscalar meson behavior and restoration of symmetries in SU(3) Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Costa, P.; Ruivo, M. C.; de Sousa, C. A.; Hansen, H.; Alberico, W. M.

    2009-06-01

    The modification of mesonic observables in a hot medium is analyzed as a tool to investigate the restoration of chiral and axial symmetries in the context of the Polyakov-loop extended Nambu-Jona-Lasinio model. The results of the extended model lead to the conclusion that the effects of the Polyakov loop are fundamental for reproducing lattice findings. In particular, the partial restoration of the chiral symmetry is faster in the Polyakov-Nambu-Jona-Lasinio model than in the Nambu-Jona-Lasinio one, and it is responsible for several effects: the meson-quark coupling constants show a remarkable difference in both models, there is a faster tendency to recover the Okubo-Zweig-Iizuka rule, and finally the topological susceptibility nicely reproduces the lattice results around T/Tc≈1.0.

  16. Pion-photon transition distribution amplitudes in the Nambu-Jona-Lasinio model

    SciTech Connect

    Courtoy, A.; Noguera, S.

    2007-11-01

    We define the pion-photon transition distribution amplitudes (TDA) in a field theoretic formalism from a covariant Bethe-Salpeter approach for the determination of the bound state. We apply our formalism to the Nambu-Jona-Lasinio model, as a realistic theory of the pion. The obtained vector and axial TDAs satisfy all features required by general considerations. In particular, sum rules and the polynomiality condition are explicitly verified. We have numerically proved that the odd coefficients in the polynomiality expansion of the vector TDA vanish in the chiral limit. The role of PCAC and the presence of a pion pole are explicitly shown.

  17. Beta function in the non-Abelian Nambu-Jona-Lasinio model in four dimensions

    SciTech Connect

    Alves, Van Sergio; Pinheiro, S. V. L.; Nascimento, Leonardo; Pena, Francisco

    2009-08-15

    In this paper we present the structure of the renormalization group in non-Abelian Nambu-Jona-Lasinio model up to 1-loop order. The model is not perturbatively renormalizable in the usual power counting sense, but it is treated as an effective theory, valid in a scale of energy in which p<<{lambda}, where p is the external momenta of the loop and {lambda} is a massive parameter that characterizes the couplings of the nonrenormalizable vertex. We clarify the tensorial structure of the interaction vertices and calculate the functions of the renormalization group. The analysis of the fixed points of the theory is also presented using Zimmermann's procedure for reducing the coupling constants. We find that the origin is an infrared-stable fixed point at low energies and also there is a nontrivial ultraviolet stable fixed point, indicating that the theory could be perturbatively investigated in the low momentum regime.

  18. Nonuniform phases in the 't Hooft extended Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Moreira, J.; Hiller, B.; Osipov, A. A.; Blin, A. H.

    2016-01-01

    The phase diagram of cold dense quark matter is studied using the 't Hooft extended Nambu-Jona-Lasinio Model applied to the light quark sector with a finite current mass for the strange quark (up and down are considered in the chiral limit). By relaxing the traditional uniformity assumptions and considering a modulated light quark condensate background we investigate the possible existence of non-uniform phases in this region of the phase diagram. The effects of changes in the coupling strengths of the model are studied and it is shown that the inclusion of flavour mixing combined with the finite current mass of the strange quark catalyses the appearance of the non-uniform phases, extending the domain for their existence.

  19. [Responsibility: Towards a fifth principle in blood transfusion's ethics. Applicability and limits of Hans Jonas's responsibility principle].

    PubMed

    Nélaton, C

    2016-09-01

    Nowadays, in France, anonymity, gratuity, volunteering, non-profit are recognized as ethical principles in blood transfusion. Can we add responsibility to this list? Can a logo named "Responsiblood" efficiently encourage blood donation? This article explores Hans Jonas's reform of the responsibility concept in order to measure its applicabilities and limits in the field of blood transfusion. Indeed, this concept - rethought by Jonas - seems to be a good encouragement which avoids the pitfalls of the concept of duty and of the idea of payment for blood donation. But can't we also see in this reform a threat to blood transfusion because of technophobia and the heuristics of fear that it involves?

  20. Thermal evolution of hybrid stars within the framework of a nonlocal Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    de Carvalho, S. M.; Negreiros, R.; Orsaria, M.; Contrera, G. A.; Weber, F.; Spinella, W.

    2015-09-01

    We study the thermal evolution of neutron stars containing deconfined quark matter in their core. Such objects are generally referred to as quark-hybrid stars. The confined hadronic matter in their core is described in the framework of nonlinear relativistic nuclear field theory. For the quark phase we use a nonlocal extension of the SU(3) Nambu-Jona-Lasinio model with vector interactions. The Gibbs condition is used to model phase equilibrium between confined hadronic matter and deconfined quark matter. Our study indicates that high-mass neutron stars may contain between 35 and 40% deconfined quark-hybrid matter in their cores. Neutron stars with canonical masses of around 1.4 M⊙ would not contain deconfined quark matter. The central proton fractions of the stars are found to be high, enabling them to cool rapidly. Very good agreement with the temperature evolution established for the neutron star in Cassiopeia A (Cas A) is obtained for one of our models (based on the popular NL3 nuclear parametrization), if the protons in the core of our stellar models are strongly paired, the repulsion among the quarks is mildly repulsive, and the mass of Cas A has a canonical value of 1.4 M⊙ .

  1. Deconfinement of neutron star matter within the Nambu-Jona-Lasinio model

    SciTech Connect

    Lugones, G.; Grunfeld, A. G.; Scoccola, N. N.; Villavicencio, C.

    2009-08-15

    We study the deconfinement transition of hadronic matter into quark matter under neutron star conditions assuming color and flavor conservation during the transition. We use a two-phase description. For the hadronic phase we use different parametrizations of a nonlinear Walecka model which includes the whole baryon octet. For the quark-matter phase we use an SU(3){sub f} Nambu-Jona-Lasinio effective model including color superconductivity. Deconfinement is considered to be a first order phase transition that conserves color and flavor. It gives a short-lived transitory colorless-quark phase that is not in {beta} equilibrium, and decays to a stable configuration in {tau}{approx}{tau}{sub weak}{approx}10{sup -8} s. However, in spite of being very short lived, the transition to this intermediate phase determines the onset of the transition inside neutron stars. We find the transition free-energy density for temperatures typical of neutron star interiors. We also find the critical mass above which compact stars should contain a quark core and below which they are safe with respect to a sudden transition to quark matter. Rather independently on the stiffness of the hadronic equation of state (EOS) we find that the critical mass of hadronic stars (without trapped neutrinos) is in the range of {approx}1.5-1.8 solar masses. This is in coincidence with previous results obtained within the MIT bag model.

  2. Extended Nambu-Jona-Lasinio model and hidden local symmetry of low energy QCD

    NASA Astrophysics Data System (ADS)

    Wakamatsu, M.

    1996-11-01

    Using the standard auxiliary field method, we derive from the extended Nambu-Jona-Lasinio model an effective meson action containing vector and axial-vector mesons in addition to Goldstone bosons. The vector and axial-vector mesons in this effective action transform as gauge fields of hidden local symmetry Glocal=[U(n)L×U(n)R]local. Here, the realization of enlarged hidden local symmetry is accomplished via the introduction of two kinds of ``compensating'' fields. For obtaining the intrinsic-parity-violating part of the action, we generalize the standard gauged Wess-Zumino-Witten action such that it also contains two kinds of ``compensators'' in addition to the usual Goldstone bosons as well as the vector and axial-vector mesons. This generalized gauged Wess-Zumino-Witten action turns out to have Gglobal×Glocal symmetry, where Gglobal is the usual U(n)L×U(n)R global chiral symmetry while Glocal is the U(n)L×U(n)R hidden local symmetry. This means that Glocal has no gauge anomaly and its associated vector and axial-vector mesons can be regarded as gauge bosons of Glocal. The introduction of the coupling with the external electroweak fields requires us to gauge some appropriate subgroup of Gglobal. To make it consistent with the anomaly structure of QCD is a nontrivial problem. We explain how this can be done, following the recent suggestion by several authors.

  3. Kaon condensation in a Nambu-Jona-Lasinio model at high density

    SciTech Connect

    Forbes, Michael McNeil

    2005-11-01

    We demonstrate a fully self-consistent microscopic realization of a kaon-condensed color-flavor locked state (CFLK{sup 0}) within the context of a mean-field Nambu-Jona-Lasinio (NJL) model at high density. The properties of this state are shown to be consistent with the QCD low-energy effective theory once the proper gauge neutrality conditions are satisfied, and a simple matching procedure is used to compute the pion decay constant, which agrees with the perturbative QCD result. The NJL model is used to compare the energies of the CFLK{sup 0} state to the parity even CFL state, and to determine locations of the metal/insulator transition to a phase with gapless fermionic excitations in the presence of a nonzero hypercharge chemical potential and a nonzero strange quark mass. The transition points are compared with results derived previously via effective theories and with partially self-consistent NJL calculations. We find that the qualitative physics does not change, but that the transitions are slightly lower.

  4. Chirally symmetric O(1/N{sub c}) corrections to the Nambu-Jona-Lasinio model

    SciTech Connect

    Dmitrasinovic, V.; Schulze, H.J.; Tegen, R.

    1995-03-01

    We develop an extended chirally symmetric self-consistent approximation scheme to the Nambu-Jona-Lasinio model, that corresponds to O(1/N{sub c}) corrections to the usual Hartree + random phase approximations. This scheme amounts to adding {open_quotes}meson cloud{close_quotes} contributions self-consistently to the quark self-energy and the meson polarization functions in a manner suggested by the weakly interacting nature of the quark and collective meson degrees of freedom of the NJL model in the large N{sub c} limit. We demonstrate explicitly that this scheme fulfills all the chiral symmetry theorems, namely the Goldstone theorem, the Goldberger-Treiman relation, and the conservation of the quark axial current. We explore the corrections to the quark self-energy and scalar condensate, as well as to the pion polarization function and the weak decay constant N{sub n}. The numerical evaluation of these corrections is presented and discussed. 23 refs., 14 figs., 2 tabs.

  5. High density quark matter in the Nambu-Jona-Lasinio model with dimensional versus cutoff regularization

    SciTech Connect

    Fujihara, T.; Kimura, D.; Inagaki, T.; Kvinikhidze, A.

    2009-05-01

    We investigate color superconducting phase at high density in the extended Nambu-Jona-Lasinio model for two-flavor quarks. Because of the nonrenormalizability of the model, physical observables may depend on the regularization procedure; that is why we apply two types of regularization, the cutoff and the dimensional one to evaluate the phase structure, the equation of state, and the relationship between the mass and the radius of a dense star. To obtain the phase structure we evaluate the minimum of the effective potential at finite temperature and chemical potential. The stress tensor is calculated to derive the equation of state. Solving the Tolman-Oppenheimer-Volkoff equation, we show the relationship between the mass and the radius of a dense star. The dependence on the regularization is found not to be small, interestingly. The dimensional regularization predicts color superconductivity phase at rather large values of {mu} (in agreement with perturbative QCD in contrast to the cutoff regularization), in the larger temperature interval, the existence of heavier and larger quark stars.

  6. Symmetry energy and neutron star properties in the saturated Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Wei, Si-Na; Jiang, Wei-Zhou; Yang, Rong-Yao; Zhang, Dong-Rui

    2016-12-01

    In this work, we adopt the Nambu-Jona-Lasinio (NJL) model that ensures the nuclear matter saturation properties to study the density dependence of the symmetry energy. With the interactions constrained by the chiral symmetry, the symmetry energy shows novel characters different from those in conventional mean-field models. First, the negative symmetry energy at high densities that is absent in relativistic mean-field (RMF) models can be obtained in the RMF approximation by introducing a chiral isovector-vector interaction, although it would be ruled out by the neutron star (NS) stability. Second, with the inclusion of the isovector-scalar interaction the symmetry energy exhibits a general softening at high densities even for the large slope parameter of the symmetry energy. The NS properties obtained in the present NJL model can be in accord with the observations. The NS maximum mass obtained with various isovector-scalar couplings and momentum cutoffs is well above the 2M⊙, and the NS radius obtained well meets the limits extracted from recent measurements. In particular, the significant reduction of the canonical NS radius occurs with the moderate decrease of the slope of the symmetry energy.

  7. Interface tension and interface entropy in the 2+1 flavor Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ke, Wei-yao; Liu, Yu-xin

    2014-04-01

    We study the QCD phases and their transitions in the 2+1 flavor Nambu-Jona-Lasinio model, with a focus on the interface effects such as the interface tension, the interface entropy, and the critical bubble size in the coexistence region of the first-order phase transitions. Our results show that under the thin-wall approximation, the interface contribution to the total entropy density changes its discontinuity scale in the first-order phase transition. However, the entropy density of the dynamical chiral symmetry (DCS) phase is always greater than that of the dynamical chiral symmetry broken (DCSB) phase in both the heating and hadronization processes. To address this entropy puzzle, the thin-wall approximation is evaluated in the present work. We find that the puzzle can be attributed to an overestimate of the critical bubble size at low temperature in the hadronization process. With an improvement on the thin-wall approximation, the entropy puzzle is well solved with the total entropy density of the hadron-DCSB phase exceeding apparently that of the DCS-quark phase at low temperature.

  8. Gauged Nambu-Jona-Lasinio model with extra dimensions: Phase structure and renormalizability

    SciTech Connect

    Gusynin, Valery P.; Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2004-11-01

    We investigate phase structure of the D(>4)-dimensional gauged Nambu-Jona-Lasinio (NJL) model with {delta}(=D-4) extra dimensions compactified on TeV scale, based on the improved ladder Schwinger-Dyson (SD) equation in the bulk. We assume that the bulk (dimensionless) running gauge coupling in the SD equation for the SU(N{sub c}) gauge theory with N{sub f} massless flavors is given by the truncated Kaluza-Klein effective theory and hence has a nontrivial ultraviolet fixed point (UVFP), resulting in the walking coupling. We find the critical line in the parameter space of two couplings, the gauge coupling (value fixed at the UVFP) and the (dimensionless) four-fermion coupling, which is similar to that of the gauged NJL model with fixed (walking) gauge coupling in four dimensions. It is shown that in the presence of such walking gauge interactions the four-fermion interactions become nontrivial and renormalizable even in higher dimensions, similar to the four dimensional gauged NJL model. Such a renormalizability/nontriviality holds only in the restricted region of the critical line ('nontrivial window') with the gauge coupling larger than a nonvanishing value ('marginal triviality' point), in contrast to the four dimensional case where such a renormalizability holds for all regions of the critical line except for the pure NJL point (without gauge coupling). In the nontrivial window the renormalized effective potential yields a nontrivial interaction which is conformal invariant. The existence of the nontrivial window implies 'cutoff insensitivity' of the physics prediction in spite of the ultraviolet dominance of the dynamics. In the formal limit D{yields}4, the nontrivial window shrinks to the pure NJL point but with a nontrivial condition which coincides with the known condition of the renormalizability/nontriviality of the four dimensional gauged NJL model (9/2)(1/N{sub c})

  9. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. . Inst. for Nuclear Theory Inst. fuer Theoretische Physik 2, Ruhr-Univ. Bochum ); Diakonov, D.; Petrov, V.; Pobylitsa, P.V. ); Park, N.W. Center for Theoretical Physics, Seoul National Univ. (Korea, Republic

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  10. The SU(3)-Nambu-Jona-Lasinio soliton in the collective quantization formulation

    SciTech Connect

    Blotz, A.; Goeke, K. |; Diakonov, D.; Petrov, V.; Pobylitsa, P.V.; Park, N.W. |

    1992-06-11

    On grounds of a semibosonized Nambu-Jona-Lasinio model, which has SU(3){sub R}{circle_times}SU(3){sub L}-symmetry in the chiral limit, mass splittings for spin 1/2 and spin 3/2 baryons are studied in the presence of an explicit chiral symmetry breaking strange quark mass. To this aim these strangeness carrying baryons are understood as SU(3)-rotational excitations of an SU(2)-embedded soliton solution. Therefore, within the framework of collective quantization, the fermion determinant with the strange quark mass is expanded up to the second order in the flavor rotation velocity and up to the first order in this quark mass. Besides the strange and non-strange moments of inertia, which have some counterparts within the Skyrme model, some so-called anomalous moments of inertia are obtained. These call be related to the imaginary part of the effective Euclidian action and contain among others the anomalous baryon current. This is shown in a gradient expansion up to the first non-vanishing order. Together with the {Sigma}-commutator these are the solitonic ingredients of the collective hamiltonian, which is then diagonalized by means of strict perturbation theory in the strange quark mass and by the Yabu-Audo method. Both methods yield very good results for the masses of the spin 1/2 and 3/2 baryons. The former one reproduces some interesting mass formulas of Gell-Mann Okubo and Guadagnini and the latter one is able to describe the mass splittings up to a few MeV.

  11. Thermomagnetic properties of the strong coupling in the local Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ayala, Alejandro; Dominguez, C. A.; Hernández, L. A.; Loewe, M.; Raya, Alfredo; Rojas, J. C.; Villavicencio, C.

    2016-09-01

    We study the thermomagnetic properties of the strong coupling constant G and quark mass M entering the Nambu-Jona-Lasinio model. For this purpose, we compute the quark condensate and compare it to lattice QCD (LQCD) results to extract the behavior of G and M as functions of the magnetic field strength and temperature. We find that at zero temperature, where the LQCD condensate is found to monotonically increase with the field strength, M also increases whereas G remains approximately constant. However, for temperatures above the chiral/deconfinement phase transitions, where the LQCD condensate is found to monotonically decrease with increasing field, M and G also decrease monotonically. For finite temperatures, below the transition temperature, we find that both G and M initially grow and then decrease with increasing field strength. To study possible consequences of the extracted temperature and magnetic field dependence of G and M , we compute the pressure and compare to LQCD results, finding an excellent qualitative agreement. In particular, we show that the transverse pressure, as a function of the field strength, is always negative for temperatures below the transition temperature whereas it starts off being positive and then becomes negative for temperatures above the transition temperature, also in agreement with LQCD results. We also show that for the longitudinal pressure to agree with LQCD calculations, the system should be described as a diamagnet. We argue that the turnover of M and G as functions of temperature and field strength is a key element that drives the behavior of the quark condensate going across the transition temperature and provides clues for a better understanding of the inverse magnetic catalysis phenomenon.

  12. Unified composite scenario for inflation and dark matter in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Channuie, Phongpichit; Xiong, Chi

    2017-02-01

    In this work, we propose a cosmological scenario inherently based on the effective Nambu-Jona-Lasinio (NJL) model that cosmic inflation and dark matter can be successfully described by a single framework. On the one hand, the scalar channel of the NJL model plays a role of the composite inflaton (CI) and we show that it is viable to achieve successful inflation via a nonminimal coupling to gravity. For model of inflation, we compute the inflationary parameters and confront them with recent Planck 2015 data. We discover that the predictions of the model are in excellent agreement with the Planck analysis. We also present in our model a simple connection of physics from the high scales to low scales via renormalization group equations (RGEs) of the physical parameters and use them to estimate the range of relevant parameters. On the other hand, the pseudoscalar channel can be assigned as a candidate for composite dark matter (CD). For a model of dark matter, we couple the pseudoscalar to the Higgs sector of the standard model with the coupling strength κ and estimate its thermally averaged relic abundance. We discover that the CD mass is strongly sensitive to the coupling κ . We find in case of light CD, MsMW ,Z (or >Mh), the required relic abundance can be satisfied for value of the CD mass Ms˜410 GeV for κ =0.5 . In contradiction to the light mass case, however, the CD mass in this case can even be heavier when the coupling is getting larger.

  13. Cosmological implications of Nambu-Jona-Lasinio model with a dynamical coupling

    NASA Astrophysics Data System (ADS)

    Quintanar, G. Leonardo; de La Macorra, Axel

    We study the cosmological implications of the Nambu-Jona-Lasinio (NJL) model when the coupling constant is field dependent. The NJL model has a four-fermion interaction describing two different phases due to quantum interaction effects and determined by the strength of the coupling constant g. It describes massless fermions for weak coupling and a massive fermions and strong coupling, where a fermion condensate is formed. In the original NJL model, the coupling constant g is indeed constant, and in this work we consider a modified version of the NJL model by introducing a dynamical field dependent coupling motivated by string theory. The effective potential as a function of the varying coupling (aimed to implement a natural phase transition) is seen to develop a negative divergence, i.e. becomes a “bottomless well” in certain limit region. Although we explain how an lower unbounded potential is not necessarily unacceptable in a cosmological context, the divergence can be removed if we consider a mass term for the coupling like field. We found that for a proper set of parameters, the total potential obtained has two minima, one located at the origin (the trivial solution, in which the fluid associated with the fields behave like matter); and the other related to the nontrivial solution. This last solution has three possibilities: (1) if the minimum is positive Vmin > 0, the system behaves as a cosmological constant, thus leading eventually to an accelerated universe; (2) if the minimized potential vanishes Vmin = 0, then we have matter with no acceleration; (3) finally a negative minimum Vmin < 0 leads an eventually collapsing universe with a flat geometry. Therefore, a possible interpretation as dark matter (DM) or dark energy (DE) is allowed among the behaviors implicated in the model.

  14. A study of diquark and meson condensation in the Nambu-Jona-Lasinio model and Fermi momentum

    NASA Astrophysics Data System (ADS)

    Ghosh, R.; Bhattacharya, A.; Chakrabarti, B.

    2017-01-01

    Using a three- and four-dimensional Pauli-Villars regularization scheme, we investigate quark-antiquark and diquark condensation in the framework of the Nambu-Jona-Lasinio model. Using the particle Fermi momentum as a cutoff parameter, we study the energy gap width and coherence length for the meson condensate . We also study the energy gap width and critical coherence length ( the distance over which there would be no diquark condensation) for the diquark < qq> and the dependence on the Fermi momentum. We obtain an estimate of the Fermi momentum value for meson and diquark condensates with an energy gap width of the order of 100 MeV.

  15. Shear and bulk viscosities of quark matter from quark-meson fluctuations in the Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Ghosh, Sabyasachi; Peixoto, Thiago C.; Roy, Victor; Serna, Fernando E.; Krein, Gastão

    2016-04-01

    We have calculated the temperature dependence of shear η and bulk ζ viscosities of quark matter due to quark-meson fluctuations. The quark thermal width originating from quantum fluctuations of quark-π and quark-σ loops at finite temperature is calculated with the formalism of real-time thermal field theory. Temperature-dependent constituent-quark and meson masses and quark-meson couplings are obtained in the Nambu-Jona-Lasinio model. We found a nontrivial influence of the temperature-dependent masses and couplings on the Landau-cut structure of the quark self-energy. Our results for the ratios η /s and ζ /s , where s is the entropy density (also determined in the Nambu-Jona-Lasinio model in the quasiparticle approximation), are in fair agreement with results of the literature obtained from different models and techniques. In particular, our result for η /s has a minimum very close to the quantum lower bound, η /s =1 /4 π .

  16. Solitonic solutions of the SU(2) Nambu-Jona-Lasinio model with σ, π, ρ, A1 and ω mesons

    NASA Astrophysics Data System (ADS)

    Döring, F.; Schüren, C.; Arriola, E. Ruiz; Goeke, K.

    1993-01-01

    We present the first solitonic solutions of the SU(2) Nambu-Jona-Lasinio model including σ, π, ρ, A1 and ω mesons for hedgehog configurations on the chiral circle. The lagrangian incorporates Sakurai's universality and vector meson dominance by means of current-field identities. In order to fix the parameters of the lagrangian we make use of the full momentum dependent mesonic two point functions in the one quark loop approximation. For reasonable values of the consistuent quark mass we find that solitons exist provided that mω>870 MeV. In addition, whether the baryon number is carried by valence quarks or by the Dirac sea, depends strongly on the particular values of the constituent quark mass and the ω meson mass.

  17. A comparative study on two different approaches of bulk viscosity in the Polyakov-Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Saha, Kinkar; Upadhaya, Sudipa; Ghosh, Sabyasachi

    2017-02-01

    We have gone through a comparative study on two different kinds of bulk viscosity expressions by using a common dynamical model. The Polyakov-Nambu-Jona-Lasinio (PNJL) model in the realm of mean-field approximation, including up to eight quark interactions for 2+1 flavor quark matter, is treated for this common dynamics. We have probed the numerical equivalence as well as discrepancy of two different expressions for bulk viscosity at vanishing quark chemical potential. Our estimation of bulk viscosity to entropy density ratio follows a decreasing trend with temperature, which is observed in most of the earlier investigations. We have also extended our estimation for finite values of quark chemical potential.

  18. Phase diagram for the Nambu-Jona-Lasinio model with 't Hooft and eight-quark interactions

    NASA Astrophysics Data System (ADS)

    Hiller, B.; Moreira, J.; Osipov, A. A.; Blin, A. H.

    2010-06-01

    It is shown that the end point of the first-order transition line, which merges into a crossover regime in the phase diagram of the Nambu-Jona-Lasinio model, extended to include the six-quark ’t Hooft and eight-quark interaction Lagrangians, is pushed toward vanishing chemical potential and higher temperatures with increasing strength of the Okubo-Zweig-Iizuka-violating eight-quark interactions. We clarify the connection between the location of the end point in the phase diagram and the mechanism of chiral symmetry breaking at the quark level. We show how the 8q interactions affect the number of effective quark degrees of freedom. We are able to obtain the correct asymptotics for this number at large temperatures by using the Pauli-Villars regularization.

  19. Neutron stars: From the inner crust to the core with the (extended) Nambu-Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Pais, Helena; Menezes, Débora P.; Providência, Constança

    2016-06-01

    Nucleonic matter is described within an SU(2) extended Nambu-Jona-Lasinio (NJL) model. Several parametrizations with different nuclear matter saturation properties are proposed. At subsaturation, nuclear pasta phases are calculated within two methods: the coexistence-phases approximation and the compressible liquid drop model, with the surface tension coefficient determined using a geometrical approach at zero temperature. A unified equation of state of stellar matter for the inner crust, with the nuclear pasta phases, and the core is calculated. The mass and radius of neutron stars within this framework are obtained for several families of hadronic and hybrid stars. The quark phase of hybrid stars is described within the SU(3) NJL model including a vector term. Stellar macroscopic properties are in accordance with some of the recent results in the literature.

  20. Pion polarizability in the Nambu-Jona-Lasinio model and possibilities of its experimental studies in Coulomb nuclear scattering

    SciTech Connect

    Bystritskiy, Yu. M.; Guskov, A. V.; Pervushin, V. N.; Volkov, M. K.

    2009-12-01

    The charge pion polarizability is calculated in the Nambu-Jona-Lasinio model, where the quark loops (in the mean field approximation) and the meson loops (in the 1/N{sub c} approximation) are taken into account. We show that quark loop contribution dominates because the meson loops strongly conceal each other. The sigma-pole contribution (m{sub {sigma}}{sup 2}-t){sup -1} plays the main role and contains strong t-dependence of the effective pion polarizability at the region |t|{>=}4M{sub {pi}}{sup 2}. Possibilities of experimental test of this sigma-pole effect in the reaction of Coulomb nuclear scattering are estimated for the COMPASS experiment.

  1. A new species of sand crab Jonas Hombron & Jacquinot, 1846 (Crustacea:
    Decapoda: Brachyura: Corystidae) from the southeastern coast of India.

    PubMed

    Barathkumar, S; Das, N P I; Satpathy, K K

    2016-02-15

    A new species of sand crab of the genus Jonas Hombron & Jacquinot, 1846 (family Corystidae) is described from specimens collected from Kalpakkam, southeastern coast of India. Two other species, J. indicus (Chopra, 1935), and J. choprai Serène, 1971, have previously been recorded from this area. A detailed description of the new species is given and compared with the closely related J. formosae Balss, 1922, also from the Indo-West Pacific.

  2. BCS, Nambu-Jona-Lasinio, and Han-Nambu: A sketch of Nambu's works in 1960-1965

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2016-06-01

    The years 1960-1965 were a remarkable period for Yoichiro Nambu. Starting with a reformulation of BCS theory with emphasis on gauge invariance, he recognized the realization of spontaneous chiral symmetry breaking in particle physics as evidenced by the Goldberger-Treiman relation. A concrete model of Nambu and Jona-Lasinio illustrated the essence of the Nambu-Goldstone theorem and the idea of soft pions. After the proposal of the quark model by Gell-Mann, he together with Han constructed an alternative model of integrally charged quarks with possible non-Abelian gluons. All these remarkable works were performed during the years 1960-1965. Here I briefly review those works following the original papers of Nambu chronologically, together with a brief introduction to a formulation of Noether's theorem and the Ward-Takahashi identities using path integrals. This article is mostly based on a lecture given at the Nambu Memorial Symposium held at Osaka City University in September 2015, where Nambu started his professional career.

  3. Enforced neutrality and color-flavor unlocking in the three-flavor Polyakov-loop Nambu Jona-Lasinio model

    NASA Astrophysics Data System (ADS)

    Abuki, H.; Ciminale, M.; Gatto, R.; Nardulli, G.; Ruggieri, M.

    2008-04-01

    We study how the charge neutrality affects the phase structure of the three-flavor Polyakov-loop Nambu Jona-Lasinio (PNJL) model. We point out that, within the conventional PNJL model at finite density, the color neutrality is missing because the Wilson line serves as an external colored field coupled to dynamical quarks. In this paper we heuristically assume that the model may still be applicable. To get color neutrality, one has then to allow nonvanishing color chemical potentials. We study how the quark matter phase diagram in (T,ms2/μ)-plane is affected by imposing neutrality and by including the Polyakov-loop dynamics. Although these two effects are correlated in a nonlinear way, the impact of the Polyakov loop turns out to be significant in the T direction, while imposing neutrality brings a remarkable effect in the ms2/μ direction. In particular, we find a novel unlocking transition, when the temperature is increased, even in the chiral SU(3) limit. We clarify how and why this is possible once the dynamics of the colored Polyakov loop is taken into account. Also we succeed in giving an analytic expression for Tc for the transition from two-flavor pairing (2SC) to unpaired quark matter in the presence of the Polyakov loop.

  4. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    DOE PAGES

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization schememore » for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.« less

  5. Collective modes and Kosterlitz-Thouless transition in a magnetic field in the planar Nambu–Jona-Lasinio model

    SciTech Connect

    Cao, Gaoqing; He, Lianyi; Zhuang, Pengfei

    2014-09-15

    It is known that a constant magnetic field is a strong catalyst of dynamical chiral symmetry breaking in 2+1 dimensions, leading to generating dynamical fermion mass even at weakest attraction. In this work we investigate the collective modes associated with the dynamical chiral symmetry breaking in a constant magnetic field in the (2+1)-dimensional Nambu–Jona-Lasinio model with continuous U(1) chiral symmetry. We introduce a self-consistent scheme to evaluate the propagators of the collective modes at the leading order in 1/N. The contributions from the vacuum and from the magnetic field are separated such that we can employ the well-established regularization scheme for the case of vanishing magnetic field. The same scheme can be applied to the study of the next-to-leading order correction in 1/N. We show that the sigma mode is always a lightly bound state with its mass being twice the dynamical fermion mass for arbitrary strength of the magnetic field. Since the dynamics of the collective modes is always 2+1 dimensional, the finite temperature transition should be of the Kosterlitz-Thouless (KT) type. We determine the KT transition temperature TKT as well as the mass melting temperature T* as a function of the magnetic field. It is found that the pseudogap domain TKT < T < T* is enlarged with increasing strength of the magnetic field. The influence of a chiral imbalance or axial chemical potential μ5 is also studied. We find that even a constant axial chemical potential μ5 can lead to inverse magnetic catalysis of the KT transition temperature in 2+1 dimensions. As a result, the inverse magnetic catalysis behavior is actually the de Haas–van Alphen oscillation induced by the interplay between the magnetic field and the Fermi surface.

  6. Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2014-12-01

    The Swedish astronomer Anders Jonas Ångström, born two centuries ago and professor of physics at Uppsala University, was one of the founders of optical spectroscopy. By using diffraction gratings out of glass plates with fine scorings across the face, he was able to observe the spectrum of the Sun, announcing in 1862 that he had discovered the lines of hydrogen in the solar spectrum. His most important work, 'Recherches sur la Spectre Solaire', including an atlas of close to a thousand spectral lines, became the standard of spectroscopy for at least a quarter of a century. This article deals with his life as well as his main contributions to the development of several areas of physical science, stressing his pioneer activities in spectroscopy.

  7. Radiative decays of radially excited mesons {pi}{sup 0'}, {rho}{sup 0'}, and {omega}{sup '} in the Nambu-Jona-Lasinio model

    SciTech Connect

    Kuraev, E. A.; Volkov, M. K.; Arbuzov, A. B.

    2010-12-15

    Radiative decays {pi}{sup 0}({pi}{sup 0'}){yields}{gamma}+{gamma}, {pi}{sup 0'{yields}{rho}0}({omega})+{gamma}, {rho}{sup 0'}({omega}{sup '}){yields}{pi}{sup 0}+{gamma}, and {rho}{sup 0'}({omega}{sup '}){yields}{pi}{sup 0'}+{gamma} are considered in the framework of the SU(2)xSU(2) Nambu-Jona-Lasinio (NJL) model. Radially excited mesons are described with the help of a simple polynomial form factor. In spite of mixing of the ground and excited meson states in this model, the decay widths of {pi}{sup 0{yields}{gamma}}+{gamma} and {rho}{sup 0}({omega}){yields}{pi}{sup 0}+{gamma} are found to be in good agreement with experimental data, as in the standard NJL model. Our predictions for decay widths of radially excited mesons can be verified in future experiments.

  8. Implications of the measurement of pulsars with two solar masses for quark matter in compact stars and heavy-ion collisions: A Nambu-Jona-Lasinio model case study

    NASA Astrophysics Data System (ADS)

    Klähn, T.; Łastowiecki, R.; Blaschke, D.

    2013-10-01

    The precise measurements of the high masses of the pulsars PSR J1614-2230 (M1614=1.97±0.04M⊙) and PSR J0348-0432 (M0348=2.01±0.04M⊙) provide an important constraint for the equation of state of cold, dense matter and are suited to give interesting insights regarding the nature and existence of the possible phase transition to deconfined quark matter in the cores of neutron stars. We analyze the stability and composition of compact star sequences for a class of hybrid nuclear-quark-matter equations of state. The quark matter phase is described in the framework of a standard color superconducting 3-flavor Nambu-Jona-Lasinio model, and the hadronic phase is given by the Dirac-Brueckner-Hartree-Fock equation of state for the Bonn-A potential. The phase transition is obtained by a Maxwell construction. Within this model setup, we aim to constrain otherwise not strictly fixed parameters of the Nambu-Jona-Lasinio model, namely, the coupling strengths in the vector meson and diquark interaction channels. We perform this investigation for two different parametrizations characterized by a different scalar coupling constant. The analysis of flow data obtained in heavy-ion collisions resulted in a further constraint that we account for in our discussion. Massive hybrid stars with extended quark matter cores can be obtained in accordance with all of the considered constraints.

  9. Phenomenological implications of a predictive formulation of the Nambu-Jona-Lasinio model having tensor couplings and isospin symmetry breaking terms

    NASA Astrophysics Data System (ADS)

    Battistel, O. A.; Pimenta, T. H.; Dallabona, G.

    2016-10-01

    In the present work we consider the phenomenological consequences of a predictive formulation of the Nambu-Jona-Lasinio (NJL) model at the one loop level of perturbative calculations. The investigation reported here can be considered as an extension of previously made ones on the same issue. In the study made in this work we have included vector and tensor couplings, simultaneously, as well as S U (2 ) isospin symmetry breaking terms. As a consequence of the last ingredient mentioned, there are different masses in the model amplitudes. In spite of this, within the context of the adopted procedure, we verify that it is possible to eliminate unphysical dependencies on the arbitrary choices for the routing of internal lines momenta as well as Ward identities violating contributions and scale ambiguous terms, from the corresponding one loop amplitudes, through the simple and universal Consistency Relations. The total content of divergence of the amplitudes is reduced to only two basic divergent objects. They are related to two inputs of the model in a way that, due to their scale properties, an unique arbitrariness remains. However, due to the critical condition found in the mechanism which generates the constituent quark mass, within our approach, this arbitrariness is also removed turning the model predictive in the sense that its phenomenological consequences is not dependent in possible choices made in intermediary steps of the calculations, as occurs in usual treatments. In this scenario, we investigate the most typical static properties of the scalar, pseudoscalar, vector and axial-vector mesons at low-energy. Special attention is given to the consequences of the S U (2 ) isospin symmetry breaking for the phenomenological predictions. The implications of the tensor couplings for the model observables, which can be considered an original contribution of the present work, at the level of the content and not only in the form, is analyzed in a detailed way. The found

  10. Nonuniform phases in the ’t Hooft extended Nambu–Jona-Lasinio model

    SciTech Connect

    Moreira, J.; Hiller, B.; Blin, A. H.; Osipov, A. A.

    2016-01-22

    The phase diagram of cold dense quark matter is studied using the ’t Hooft extended Nambu-Jona–Lasinio Model applied to the light quark sector with a finite current mass for the strange quark (up and down are considered in the chiral limit). By relaxing the traditional uniformity assumptions and considering a modulated light quark condensate background we investigate the possible existence of non-uniform phases in this region of the phase diagram. The effects of changes in the coupling strengths of the model are studied and it is shown that the inclusion of flavour mixing combined with the finite current mass of the strange quark catalyses the appearance of the non-uniform phases, extending the domain for their existence.

  11. A modified Nambu-Jona-Lasinio model for mesons and baryons

    NASA Astrophysics Data System (ADS)

    Masayuki, Katô; Wolfgang, Bentz; Koichi, Yazaki; Kazuhiro, Tanaka

    1993-01-01

    A baryon-like bound state of three valence quarks in the NJL model is investigated. We find that in the flavor SU(2) case there exists no such state. Using the modified flavor SU(3) model we can obtain a baryon-like state. The essential ingredient which stabilizes the system is the "instanton-induced" six-fermion interaction describing the U A(1) anomaly in a phenomenological way. The properties of mesons are also investigated in this model.

  12. Aspects of U {sub A} (1) breaking in the Nambu and Jona-Lasinio model

    SciTech Connect

    Osipov, A.A. . E-mail: osipov@nusun.jinr.ru; Hiller, B. . E-mail: brigitte@teor.fis.uc.pt; Bernard, V. . E-mail: bernard@lpt6.u-strasbg.fr; Blin, A.H. . E-mail: alex@teor.fis.uc.pt

    2006-11-15

    The six-quark instanton induced 't Hooft interaction, which breaks the unwanted U {sub A} (1) symmetry of QCD, is a source of perturbative corrections to the leading order result formed by the four-quark forces with the U {sub L} (3) x U {sub R} (3) chiral symmetry. A detailed quantitative calculation is carried out to bosonize the model by the functional integral method. We concentrate our efforts on finding ways to integrate out the auxiliary bosonic variables. The functional integral over these variables cannot be evaluated exactly. We show that the modified stationary phase approach leads to a resummation within the perturbative series and calculate the integral in the 'two-loop' approximation. The result is a correction to the effective mesonic Lagrangian which may be important for the low-energy spectrum and dynamics of the scalar and pseudoscalar nonets.

  13. Hydrologic data of the coastal drainage basins of southeastern Massachusetts, Weir River, Hingham, to Jonas River, Kingston

    USGS Publications Warehouse

    Williams, John R.; Willey, Richard E.; Tasker, Gary D.

    1975-01-01

    This report presents, in tabular form, selected records of wells, test wells, borings, and springs; measurements of stream discharge, specific conductance, and temperature at partial-record stations; chemical analyses of ground water and surface water; and a summary of municipal water sources and additional sources available. The data were collected during a study of the drainage basins from 1969 to 1971 in cooperation with the Massachusetts Water Resources Commission. The report is released in order to make available to the public and to local, state, and federal agencies basic hydrologic information that may aid in planning water-resources development. Basic records contained in this report and streamflow data published elsewhere (U.S. Geol. Survey, 1960 et seq.) complement an interpretive report (Williams and Tasker, 1974).

  14. Nonlocal Polyakov-Nambu-Jona-Lasinio model with wave function renormalization at finite temperature and chemical potential

    SciTech Connect

    Contrera, G. A.; Orsaria, M.; Scoccola, N. N.

    2010-09-01

    We study the phase diagram of strongly interacting matter in the framework of a nonlocal SU(2) chiral quark model which includes wave function renormalization and coupling to the Polyakov loop. Both nonlocal interactions based on the frequently used exponential form factor, and on fits to the quark mass and renormalization functions obtained in lattice calculations are considered. Special attention is paid to the determination of the critical points, both in the chiral limit and at finite quark mass. In particular, we study the position of the critical end point as well as the value of the associated critical exponents for different model parametrizations.

  15. A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women.

    PubMed

    Huchko, Megan J; Sneden, Jennifer; Zakaras, Jennifer M; Smith-McCune, Karen; Sawaya, George; Maloba, May; Bukusi, Elizabeth Ann; Cohen, Craig R

    2015-01-01

    Visual inspection with Acetic Acid (VIA) and Visual Inspection with Lugol’s Iodine (VILI) are increasingly recommended in various cervical cancer screening protocols in low-resource settings. Although VIA is more widely used, VILI has been advocated as an easier and more specific screening test. VILI has not been well-validated as a stand-alone screening test, compared to VIA or validated for use in HIV-infected women. We carried out a randomized clinical trial to compare the diagnostic accuracy of VIA and VILI among HIV-infected women. Women attending the Family AIDS Care and Education Services (FACES) clinic in western Kenya were enrolled and randomized to undergo either VIA or VILI with colposcopy. Lesions suspicious for cervical intraepithelial neoplasia 2 or greater (CIN2+) were biopsied. Between October 2011 and June 2012, 654 were randomized to undergo VIA or VILI. The test positivity rates were 26.2% for VIA and 30.6% for VILI (p = 0.22). The rate of detection of CIN2+ was 7.7% in the VIA arm and 11.5% in the VILI arm (p = 0.10). There was no significant difference in the diagnostic performance of VIA and VILI for the detection of CIN2+. Sensitivity and specificity were 84.0% and 78.6%, respectively, for VIA and 84.2% and 76.4% for VILI. The positive and negative predictive values were 24.7% and 98.3% for VIA, and 31.7% and 97.4% for VILI. Among women with CD4+ count < 350, VILI had a significantly decreased specificity (66.2%) compared to VIA in the same group (83.9%, p = 0.02) and compared to VILI performed among women with CD4+ count ≥ 350 (79.7%, p = 0.02). VIA and VILI had similar diagnostic accuracy and rates of CIN2+ detection among HIV-infected women.

  16. Characterisation of 12 microsatellite loci in the Vietnamese commercial clam Lutraria rhynchaena Jonas 1844 (Heterodonta: Bivalvia: Mactridae) through next-generation sequencing.

    PubMed

    Thai, Binh Thanh; Tan, Mun Hua; Lee, Yin Peng; Gan, Han Ming; Tran, Trang Thi; Austin, Christopher M

    2016-05-01

    The marine clam Lutraria rhynchaena is gaining popularity as an aquaculture species in Asia. Lutraria populations are present in the wild throughout Vietnam and several stocks have been established and translocated for breeding and aquaculture grow-out purposes. In this study, we demonstrate the feasibility of utilising Illumina next-generation sequencing technology to streamline the identification and genotyping of microsatellite loci from this clam species. Based on an initial partial genome scan, 48 microsatellite markers with similar melting temperatures were identified and characterised. The 12 most suitable polymorphic loci were then genotyped using 51 individuals from a population in Quang Ninh Province, North Vietnam. Genetic variation was low (mean number of alleles per locus = 2.6; mean expected heterozygosity = 0.41). Two loci showed significant deviation from Hardy-Weinberg equilibrium (HWE) and the presence of null alleles, but there was no evidence of linkage disequilibrium among loci. Three additional populations were screened (n = 7-36) to test the geographic utility of the 12 loci, which revealed 100 % successful genotyping in two populations from central Vietnam (Nha Trang). However, a second population from north Vietnam (Co To) could not be successfully genotyped and morphological evidence and mitochondrial variation suggests that this population represents a cryptic species of Lutraria. Comparisons of the Qang Ninh and Nha Trang populations, excluding the 2 loci out of HWE, revealed statistically significant allelic variation at 4 loci. We reported the first microsatellite loci set for the marine clam Lutraria rhynchaena and demonstrated its potential in differentiating clam populations. Additionally, a cryptic species population of Lutraria rhynchaena was identified during initial loci development, underscoring the overlooked diversity of marine clam species in Vietnam and the need to genetically characterise population representatives prior to microsatellite development. The rapid identification and validation of microsatellite loci using next-generation sequencing technology warrant its integration into future microsatellite loci development for key aquaculture species in Vietnam and more generally, aquaculture countries in the South East Asia region.

  17. Evaluation of visual inspection with acetic acid and Lugol's iodine as cervical cancer screening tools in a low-resource setting.

    PubMed

    Qureshi, Sabuhi; Das, Vinta; Zahra, Fatima

    2010-01-01

    In view of the failure of cytology screening programmes for cervical cancer in developing countries, the World Health Organization suggested unaided visual inspection of the cervix after an application of acetic acid (VIA) and Lugol's iodine (VILI) as alternative screening methods. Our study evaluates the effectiveness of VIA and VILI compared to Pap smear as screening methods for carcinoma of the cervix in a low-resource setting. Three hundred and twenty-eight women were subjected to a Pap smear test, VIA, VILI and colposcopy. The results were as follows: Pap smear test (20.83%, specificity 98.38%), VIA (55.5%, 71.39%) and VILI (86.84%, 48.93%). Although VIA and VILI are less specific in comparison to the Pap smear test, they are more sensitive in detecting pre-invasive lesions. Hence VIA and VILI can be used as cervical cancer screening tools in low-resource settings.

  18. Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

    PubMed Central

    Pan, Shuming; Fei, Aihua; Jing, Lihong; Zhang, Xiangyu

    2017-01-01

    Inappropriate mechanical ventilation (MV) can result in ventilator-induced lung injury (VILI). Probing mechanisms of VILI and searching for effective methods are current areas of research focus on VILI. The present study aimed to probe into mechanisms of endothelial microparticles (EMPs) in VILI and the protective effects of Tetramethylpyrazine (TMP) against VILI. In this study, C57BL/6 and TLR4KO mouse MV models were used to explore the function of EMPs associated with p21 activated kinases-4 (PAK-4) in VILI. Both the C57BL/6 and TLR4 KO groups were subdivided into a mechanical ventilation (MV) group, a TMP + MV group, and a control group. After four hours of high tidal volume (20 ml/kg) MV, the degree of lung injury and the protective effects of TMP were assessed. VILI inhibited the cytoskeleton-regulating protein of PAK4 and was accompanied by an increased circulating EMP level. The intercellular junction protein of β-catenin was also decreased accompanied by a thickening alveolar wall, increased lung W/D values, and neutrophil infiltration. TMP alleviated VILI via decreasing circulating EMPs, stabilizing intercellular junctions, and alleviating neutrophil infiltration. PMID:28261612

  19. The Role of the Individual within Society: "The Giver" by Lois Lowry and "Brave New World" by Aldous Huxley. Thematic Unit.

    ERIC Educational Resources Information Center

    Tarner, Danielle; Umak, Adam

    Lois Lowry's award-winning novel, "The Giver," chronicles the strength of Jonas, an adolescent boy of 12 who lives in a utopian society. In the Community everyone is equal, and there is only a gray routine of existence. But Jonas is singled out by "The Giver," a wise old man who teaches Jonas the range of human emotions, and…

  20. Accuracy of visual inspection with acetic acid and with Lugol's iodine for cervical cancer screening: Meta-analysis.

    PubMed

    Qiao, Liang; Li, Bo; Long, Mei; Wang, Xiao; Wang, Anrong; Zhang, Guonan

    2015-09-01

    The aim of this review was to provide an updated summary estimation of the accuracy of visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI) in detecting cervical cancer and precancer. Studies on VIA/VILI accuracy were eligible in which VIA/VILI was performed on asymptomatic women who all underwent confirmatory testing of histology, combination of colposcopy and histology, or combination of multiple screening tests, colposcopy and histology, to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+ or CIN3+). A bivariate model was fitted to estimate the accuracy of VIA/VILI and provide estimates of heterogeneity. Subgroup analysis was used to investigate the source of heterogeneity. A total of 29 studies on VIA and 19 studies on VILI were included finally in the meta-analysis. The summary sensitivity and specificity of VIA for CIN2+ were 73.2% (95%CI: 66.5-80.0%) and 86.7% (95%CI: 82.9-90.4%), respectively, and those for VILI were 88.1% (95%CI: 81.5-94.7%) and 85.9% (95%CI: 81.7-90.0%), respectively. VIA and VILI were both more sensitive in detecting more severe outcome, although there was a slight loss in specificity. Apparent heterogeneity existed in sensitivity and specificity for both VIA and VILI. High sensitivity of both VIA and VILI for CIN2+ was found when a combination of colposcopy and histology was used as disease confirmation. VIA, VILI, even a combination of them in parallel, could be good options for cervical screening in low-resource settings. Significant differences in sensitivity between different gold standards might provide a proxy for optimization of ongoing cervical cancer screening programs.

  1. Corrigendum to "Historical review: Anders Jonas Ångström and the foundation of spectroscopy - Commemorative article on the second centenary of his birth" [Spectrochim. Acta Part B, 102 (2014) 12-23

    NASA Astrophysics Data System (ADS)

    Reif-Acherman, Simón

    2015-07-01

    The following addendum should be added to the Acknowledgments of the above article. Due to the multiplicity of simultaneous activities in which I am continuously involved, I forgot mentioning that Prof. Dr. Klaus Hentschel, of the History Department of the University of Stuttgart (Germany) was helpful in obtaining some of the source material used in my review. In particular, Prof. Hentschel provided the scans of Anne Beckmann's work to which I was guided by passages in his book on "Mapping the spectrum", Oxford University Press (2002). I also followed his recommendation of contacting the Swedish historians of science, and Prof. Sven Widmalm among them; however, the correspondence was not successful.

  2. Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate.

    PubMed

    Aslami, Hamid; Kuipers, Maria T; Beurskens, Charlotte J P; Roelofs, Joris J T H; Schultz, Marcus J; Juffermans, Nicole P

    2012-02-01

    In the era of lung-protective mechanical ventilation using limited tidal volumes, higher respiratory rates are applied to maintain adequate minute volume ventilation. However, higher respiratory rates may contribute to ventilator-induced lung injury (VILI). Induced hypothermia reduces carbon dioxide production and might allow for lower respiratory rates during mechanical ventilation. We hypothesized that hypothermia protects from VILI and investigated whether reducing respiratory rates enhance lung protection in an in vivo model of VILI. During 4 h of mechanical ventilation, VILI was induced by tidal volumes of 18 mL/kg in rats, with respiratory rates set at 15 or 10 breaths/min in combination with hypothermia (32°C) or normothermia (37°C). Hypothermia was induced by external cooling. A physiologic model was established. VILI was characterized by increased pulmonary neutrophil influx, protein leak, wet weights, histopathology score, and cytokine levels compared with lung protective mechanical ventilation. Hypothermia decreased neutrophil influx, pulmonary levels, systemic interleukin-6 levels, and histopathology score, and it tended to decrease the pulmonary protein leak. Reducing the respiratory rate in combination with hypothermia did not reduce the parameters of the lung injury. In conclusion, hypothermia protected from lung injury in a physiologic VILI model by reducing inflammation. Decreasing the respiratory rate mildly did not enhance protection.

  3. Ecology and Pedagogy: On the Educational Implications of Postwar Environmental Philosophy

    ERIC Educational Resources Information Center

    Hotam, Yotam

    2010-01-01

    Environmentalism, an ethical imperative to preserve and protect nature, has become in the last decade a central ethical, political and pedagogic theme. Against this background, this article focuses on the postwar philosophy of the German-Jewish scholar Hans Jonas (1903-93). It points to Jonas's radical theory of pedagogic responsibility, and to…

  4. Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding.

    PubMed

    Letsiou, Eleftheria; Sammani, Saad; Zhang, Wei; Zhou, Tong; Quijada, Hector; Moreno-Vinasco, Liliana; Dudek, Steven M; Garcia, Joe G N

    2015-02-01

    Acute lung injury (ALI) results from infectious challenges and from pathologic lung distention produced by excessive tidal volume delivered during mechanical ventilation (ventilator-induced lung injury [VILI]) and is characterized by extensive alveolar and vascular dysfunction. Identification of novel ALI therapies is hampered by the lack of effective ALI/VILI biomarkers. We explored endothelial cell (EC)-derived microparticles (EMPs) (0.1-1 μm) as potentially important markers and potential mediators of lung vascular injury in preclinical models of ALI and VILI. We characterized EMPs (annexin V and CD31 immunoreactivity) produced from human lung ECs exposed to physiologic or pathologic mechanical stress (5 or 18% cyclic stretch [CS]) or to endotoxin (LPS). EC exposure to 18% CS or to LPS resulted in increased EMP shedding compared with static cells (∼ 4-fold and ∼ 2.5-fold increases, respectively). Proteomic analysis revealed unique 18% CS-derived (n = 10) and LPS-derived EMP proteins (n = 43). VILI-challenged mice (40 ml/kg, 4 h) exhibited increased plasma and bronchoalveolar lavage CD62E (E-selectin)-positive MPs compared with control mice. Finally, mice receiving intratracheal instillation of 18% CS-derived EMPs displayed significant lung inflammation and injury. These findings indicate that ALI/VILI-producing stimuli induce significant shedding of distinct EMP populations that may serve as potential ALI biomarkers and contribute to the severity of lung injury.

  5. Concurrent evaluation of visual, cytological and HPV testing as screening methods for the early detection of cervical neoplasia in Mumbai, India.

    PubMed Central

    Shastri, Surendra S.; Dinshaw, Ketayun; Amin, Geetanjali; Goswami, Smriti; Patil, Sharmila; Chinoy, Roshini; Kane, S.; Kelkar, Rohini; Muwonge, Richard; Mahé, Cédric; Ajit, Dulhan; Sankaranarayanan, R.

    2005-01-01

    OBJECTIVE: Naked eye visual inspection with acetic acid (VIA), magnified VIA (VIAM), visual inspection with Lugol's iodine (VILI), cytology and human papillomavirus (HPV) testing were evaluated as screening methods for the detection of high-grade squamous intraepithelial lesions (HSIL) of the uterine cervix in a cross-sectional study in Mumbai, India. METHODS: Cytology, HPV testing, VIA, VIAM and VILI were carried out concurrently for 4039 women aged 30-65 years. All women were investigated with colposcopy and biopsies were taken from 939 women who had colposcopic abnormalities. The reference standard for final disease status was histology or negative colposcopy. The presence of HSIL was confirmed in 57 women (1.4%). The test characteristics for each method were calculated using standard formulae. RESULTS: The sensitivities of cytology, HPV testing, VIA, VIAM and VILI were 57.4%, 62.0%, 59.7%, 64.9%, and 75.4%, respectively (differences were not statistically significant). The specificities were 98.6%, 93.5%, 88.4%, 86.3%, and 84.3%, respectively. Adding a visual test to cytology or HPV testing in parallel combination resulted in a substantial increase in sensitivity, with a moderate decrease in specificity. The parallel combination of VILI and HPV testing resulted in a sensitivity of 92.0% and a specificity of 79.9%. CONCLUSION: As a single test, cytology had the best balance of sensitivity and specificity. Visual tests are promising in low-resource settings, such as India. The use of both VIA and VILI may be considered where good quality cytology or HPV testing are not feasible. The sensitivity of cytology and HPV testing increased significantly when combined with VIA or VILI. PMID:15798842

  6. Could Fading Sense of Smell Mean Death Is Closer?

    MedlinePlus

    ... brain health," said Olofsson, an associate professor of psychology at Stockholm University. "We see smell function as ... Society . SOURCES: Jonas Olofsson, Ph.D., associate professor, psychology, Stockholm University, Sweden; Carla Schubert, M.S., researcher, department ...

  7. Six-Month Evaluation of Extended Wear Soft Contact Lenses Among Armored Troops. Part 1. Clinical Findings

    DTIC Science & Technology

    1989-06-01

    Doctini Cou i Id s K.. ’rned A’ ’is TeSI I oumicroscorry onl asyr iptoirnac coritact-lens-wearing recruits Ar. I vili riili a I To a, QiiuviiridW ,’a...Optometry The University of Alabama, Birmingham Birmingham, AL 35294 About the Authors William G. Bachman received the Doctor of Op- tometry degree from

  8. Effect of Drag-Reducing Polymer Injection on the Lift and Drag of a Two- Dimensional Hydrofoil

    DTIC Science & Technology

    1974-09-01

    34 Johc I.. Huffma, Report 62-13, March 1962, 50 p. 21. "Technical Studies in Cargo Handling-Vili, Re-emination of Automated Ships," Raymond L. Erler and...Fleet Requirements, Raymond Erler , Report 63-8, February 1963, 23 p. 24. "Cargo Handling Research, A Ten-Year Progress Report," Staff, Report 63-4

  9. Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury

    PubMed Central

    2011-01-01

    Mechanical ventilation (MV) has the potential to worsen pre-existing lung injury or even to initiate lung injury. Moreover, it is thought that injurious MV contributes to the overwhelming inflammatory response seen in patients with acute lung injury or acute respiratory distress syndrome. Ventilator-induced lung injury (VILI) is characterized by increased endothelial and epithelial permeability and pulmonary inflammation, in which the innate immune system plays a key role. A growing body of evidence indicates that endogenous danger molecules, also termed damage-associated molecular patterns (DAMPs), are released upon tissue injury and modulate the inflammatory response. DAMPs activate pattern recognition receptors, may induce the release of proinflammatory cytokines and chemokines, and have been shown to initiate or propagate inflammation in non-infectious conditions. Experimental and clinical studies demonstrate the presence of DAMPs in bronchoalveolar lavage fluid in patients with VILI and the upregulation of pattern recognition receptors in lung tissue by MV. The objective of the present article is to review research in the area of DAMPs, their recognition by the innate immune system, their role in VILI, and the potential utility of blocking DAMP signaling pathways to reduce VILI in the critically ill. PMID:22216838

  10. Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications?

    PubMed Central

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is widely accepted as a rescue therapy in patients with acute life-threatening hypoxemia in the course of severe acute respiratory distress syndrome (ARDS). However, possible side effects and complications are considered to limit beneficial outcome effects. Therefore, widening indications with the aim of reducing ventilator induced lung injury (VILI) is still controversial. Consequently, technological progress is an important strategy. Miniaturized ECMO systems are believed to simplify handling and reduce side effects and complications. Mueller and co-workers evaluated such a small-sized device in 60 patients with severe ARDS. They accomplished both the treatment of severe hypoxemia and reduction of VILI, demonstrating feasibility, a moderate rate of severe complications, and a 45% intensive care survival rate. Although neither randomized nor controlled, this study should encourage others to implement such systems in clinical practice. From a strategic perspective, this is another small but useful step towards implementing extracorporeal gas exchange for the prevention of VILI. It is already common sense that the prevention of acute life-threatening hypoxemia usually outweighs the risks of this technique. The next step should be to prove that prevention of life-threatening VILI balances the risks too. PMID:20236482

  11. Extracorporeal gas exchange in acute lung injury: step by step towards expanded indications?

    PubMed

    Dembinski, Rolf; Kuhlen, Ralf

    2010-01-01

    Extracorporeal membrane oxygenation (ECMO) is widely accepted as a rescue therapy in patients with acute life-threatening hypoxemia in the course of severe acute respiratory distress syndrome (ARDS). However, possible side effects and complications are considered to limit beneficial outcome effects. Therefore, widening indications with the aim of reducing ventilator induced lung injury (VILI) is still controversial. Consequently, technological progress is an important strategy. Miniaturized ECMO systems are believed to simplify handling and reduce side effects and complications. Mueller and co-workers evaluated such a small-sized device in 60 patients with severe ARDS. They accomplished both the treatment of severe hypoxemia and reduction of VILI, demonstrating feasibility, a moderate rate of severe complications, and a 45% intensive care survival rate. Although neither randomized nor controlled, this study should encourage others to implement such systems in clinical practice. From a strategic perspective, this is another small but useful step towards implementing extracorporeal gas exchange for the prevention of VILI. It is already common sense that the prevention of acute life-threatening hypoxemia usually outweighs the risks of this technique. The next step should be to prove that prevention of life-threatening VILI balances the risks too.

  12. Nicotinamide Phosphoribosyltransferase Inhibitor Is a Novel Therapeutic Candidate in Murine Models of Inflammatory Lung Injury

    PubMed Central

    Moreno-Vinasco, Liliana; Quijada, Hector; Sammani, Saad; Siegler, Jessica; Letsiou, Eleftheria; Deaton, Ryan; Saadat, Laleh; Zaidi, Rafe S.; Messana, Joe; Gann, Peter H.; Machado, Roberto F.; Camp, Sara M.; Wang, Ting

    2014-01-01

    We previously identified the intracellular nicotinamide phosphoribosyltransferase (iNAMPT, aka pre–B-cell colony enhancing factor) as a candidate gene promoting acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) with circulating nicotinamide phosphoribosyltransferase potently inducing NF-κB signaling in lung endothelium. iNAMPT also synthesizes intracellular nicotinamide adenine dinucleotide (iNAD) in response to extracellular oxidative stress, contributing to the inhibition of apoptosis via ill-defined mechanisms. We now further define the role of iNAMPT activity in the pathogenesis of ARDS/VILI using the selective iNAMPT inhibitor FK-866. C57/B6 mice were exposed to VILI (40 ml/kg, 4 h) or LPS (1.5 mg/kg, 18 h) after osmotic pump delivery of FK-866 (100 mg/kg/d, intraperitoneally). Assessment of total bronchoalveolar lavage (BAL) protein, polymorphonuclear neutrophil (PMN) levels, cytokine levels (TNF-α, IL-6, IL-1α), lung iNAD levels, and injury scores revealed that FK-866–mediated iNAMPT inhibition successfully reduced lung tissue iNAD levels, BAL injury indices, inflammatory cell infiltration, and lung injury scores in LPS- and VILI-exposed mice. FK-866 further increased lung PMN apoptosis, as reflected by caspase-3 activation in BAL PMNs. These findings support iNAMPT inhibition via FK-866 as a novel therapeutic agent for ARDS via enhanced apoptosis in inflammatory PMNs. PMID:24588101

  13. Endotoxin- and mechanical stress–induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter

    PubMed Central

    Elangovan, Venkateswaran Ramamoorthi; Camp, Sara M.; Kelly, Gabriel T.; Desai, Ankit A.; Adyshev, Djanybek; Sun, Xiaoguang; Black, Stephen M.; Wang, Ting

    2016-01-01

    Abstract Mechanical ventilation, a lifesaving intervention for patients with acute respiratory distress syndrome (ARDS), also unfortunately contributes to excessive mechanical stress and impaired lung physiological and structural integrity. We have elsewhere established the pivotal role of increased nicotinamide phosphoribosyltransferase (NAMPT) transcription and secretion as well as its direct binding to the toll-like receptor 4 (TLR4) in the progression of this devastating syndrome; however, regulation of this critical gene in ventilator-induced lung injury (VILI) is not well characterized. On the basis of an emerging role for epigenetics in enrichment of VILI and CpG sites within the NAMPT promoter and 5′UTR, we hypothesized that NAMPT expression and downstream transcriptional events are influenced by epigenetic mechanisms. Concomitantly, excessive mechanical stress of human pulmonary artery endothelial cells or lipopolysaccharide (LPS) treatment led to both reduced DNA methylation levels in the NAMPT promoter and increased gene transcription. Histone deacetylase inhibition by trichostatin A or Sirt-1–silencing RNA attenuates LPS-induced NAMPT expression. Furthermore, recombinant NAMPT administration induced TLR4-dependent global H3K9 hypoacetylation. These studies suggest a complex epigenetic regulatory network of NAMPT in VILI and ARDS and open novel strategies for combating VILI and ARDS. PMID:28090296

  14. Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies

    PubMed Central

    Combescure, Christophe; Fokom-Defo, Victoire; Tebeu, Pierre Marie; Vassilakos, Pierre; Kengne, André Pascal; Petignat, Patrick

    2015-01-01

    Objective To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol’s iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. Design Systematic review and meta-analysis of diagnostic test accuracy studies. Data sources Systematic searches of multiple databases including Medline, Embase, and Scopus for studies published between January 1994 and June 2014. Review methods Inclusion criteria for studies were: alternative methods to cytology used as a standalone test for primary screening; study population not at particular risk of cervical cancer (excluding studies focusing on HIV positive women or women with gynaecological symptoms); women screened by nurses; reference test (colposcopy and directed biopsies) performed at least in women with positive screening results. Two reviewers independently screened studies for eligibility and extracted data for inclusion, and evaluated study quality using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) checklist. Primary outcomes were absolute accuracy measures (sensitivity and specificity) of screening tests to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Results 15 studies of moderate quality were included (n=61 381 for VIA, n=46 435 for VILI, n=11 322 for HPV testing). Prevalence of CIN2+ did not vary by screening test and ranged from 2.3% (95% confidence interval 1.5% to 3.3%) in VILI studies to 4.9% (2.7% to 7.8%) in HPV testing studies. Positivity rates of VILI, VIA, and HPV testing were 16.5% (9.8% to 24.7%), 16.8% (11.0% to 23.6%), and 25.8% (17.4% to 35.3%), respectively. Pooled sensitivity was higher for VILI (95.1%; 90.1% to 97.7%) than VIA (82.4%; 76.3% to 87.3%) in studies where the reference test was performed in all women (P<0.001). Pooled specificity of VILI and VIA were similar (87.2% (78.1% to 92.8%) v 87.4% (77.1% to 93

  15. VEGF Production by Ly6C+high Monocytes Contributes to Ventilator-Induced Lung Injury

    PubMed Central

    Lin, Chin-Kuo; Li, Jhy-Ming; Chen, Mei-Hsin; Tsai, Mei-Ling; Chang, Chih-Ching

    2016-01-01

    Background Mechanical ventilation is a life-saving procedure for patients with acute respiratory failure, although it may cause pulmonary vascular inflammation and leakage, leading to ventilator-induced lung injury (VILI). Ly6C+high monocytes are involved in the pathogenesis of VILI. In this study, we investigated whether pulmonary infiltrated Ly6C+high monocytes produce vascular endothelial growth factor (VEGF) and contribute to VILI. Methods A clinically relevant two-hit mouse model of VILI, with intravenous lipopolysaccharide (LPS, 20 ng/mouse) immediately before high tidal volume (HTV, 20 mL/kg) ventilation (LPS+HTV), was established. Blood gas and respiratory mechanics were measured to ensure the development of VILI. Flow cytometry and histopathological analyses revealed pulmonary infiltration of leukocytes subsets. Clodronate liposomes were intravenously injected to deplete pulmonary monocytes. In vitro endothelial cell permeability assay with sorted Ly6C+high monocytes condition media assessed the role of Ly6C+high monocytes in vascular permeability. Results LPS+HTV significantly increased total proteins, TNF-α, IL-6, vascular endothelial growth factor (VEGF) and mononuclear cells in the bronchoalveolar lavage fluid (BALF). Pulmonary Ly6C+high monocytes (SSClowCD11b+F4/80+Ly6C+high), but not Ly6C+low monocytes (SSClowCD11b+F4/80+Ly6C+low), were significantly elevated starting at 4 hr. Clodronate liposomes were able to significantly reduce pulmonary Ly6C+high monocytes, and VEGF and total protein in BALF, and restore PaO2/FiO2. There was a strong correlation between pulmonary Ly6C+high monocytes and BALF VEGF (R2 = 0.8791, p<0.001). Moreover, sorted Ly6C+high monocytes were able to produce VEGF, resulting in an increased permeability of endothelial cell monolayer in an in vitro endothelial cell permeability assay. Conclusion VEGF produced by pulmonary infiltrated Ly6C+high monocytes regulates vasculature permeability in a two-hit model of HTV-induced lung

  16. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

    SciTech Connect

    Huang, Chien-Sheng; Kawamura, Tomohiro; Peng, Ximei; Tochigi, Naobumi; Shigemura, Norihisa; Billiar, Timothy R.; Nakao, Atsunori; Toyoda, Yoshiya

    2011-05-06

    Highlights: {yields} Hydrogen is a regulatory molecule with antiinflammatory and antiapoptotic protective effects. {yields} There is very limited information on the pathways regulated in vivo by the hydrogen. {yields} Antiapoptotic abilities of hydrogen were explained by upregulation of the antiapoptotic gene. {yields} NF{kappa}B activation during hydrogen treatment was correlated with elevated antiapoptotic protein. {yields} NF{kappa}B activation associated with increase Bcl-2 may contribute to cytoprotection of hydrogen. -- Abstract: We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NF{kappa}B) signaling pathway. VILI was generated in male C57BL6 mice by performing a tracheostomy and placing the mice on a mechanical ventilator (tidal volume of 30 ml/kg or 10 ml/kg without positive end-expiratory pressure). The ventilator delivered either 2% nitrogen or 2% hydrogen in balanced air. NF{kappa}B activation, as indicated by NF{kappa}B DNA binding, was detected by electrophoretic mobility shift assays and enzyme-linked immunosorbent assay. Hydrogen gas inhalation increased NF{kappa}B DNA binding after 1 h of ventilation and decreased NF{kappa}B DNA binding after 2 h of ventilation, as compared with controls. The early activation of NF{kappa}B during hydrogen treatment was correlated with elevated levels of the antiapoptotic protein Bcl-2 and decreased levels of Bax. Hydrogen inhalation increased oxygen tension, decreased lung edema, and decreased the expression of proinflammatory mediators. Chemical inhibition of early NF{kappa}B activation using SN50 reversed these protective effects. NF{kappa}B activation and an associated increase in the expression of Bcl-2 may contribute, in part, to the

  17. The effect of low level laser therapy on ventilator-induced lung injury in mice (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Szabari, Margit V.; Miller, Alyssa J.; Hariri, Lida P.; Hamblin, Michael R.; Musch, Guido; Stroh, Helene; Suter, Melissa J.

    2016-03-01

    Although mechanical ventilation (MV) is necessary to support gas exchange in critically ill patients, it can contribute to the development of lung injury and multiple organ dysfunction. It is known that high tidal volume (Vt) MV can cause ventilator-induced lung injury (VILI) in healthy lungs and increase the mortality of patients with Acute Respiratory Distress Syndrome. Low level laser therapy (LLLT) has demonstrated to have anti-inflammatory effects. We investigated whether LLLT could alleviate inflammation from injurious MV in mice. Adult mice were assigned to 2 groups: VILI+LLLT group (3 h of injurious MV: Vt=25-30 ml/kg, respiratory rate (RR)=50/min, positive end-expiratory pressure (PEEP)=0 cmH20, followed by 3 h of protective MV: Vt=9 ml/kg, RR=140/min, PEEP=2 cmH20) and VILI+no LLLT group. LLLT was applied during the first 30 min of the MV (810 nm LED system, 5 J/cm2, 1 cm above the chest). Respiratory impedance was measured in vivo with forced oscillation technique and lung mechanics were calculated by fitting the constant phase model. At the end of the MV, bronchoalveolar lavage (BAL) was performed and inflammatory cells counted. Lungs were removed en-bloc and fixed for histological evaluation. We hypothesize that LLLT can reduce lung injury and inflammation from VILI. This therapy could be translated into clinical practice, where it can potentially improve outcomes in patients requiring mechanical ventilation in the operating room or in the intensive care units.

  18. Development of X-Ray Laser Media. Measurement of Gain and Development of Cavity Resonators for Wavelengths near 130 Angstroms. Volume 3.

    DTIC Science & Technology

    1983-02-01

    increasing need far a awe precise uderstanding of their reflecting properties. Thus, 9 ct that in the future more detailed modeling vili be... modeling of these more ozplex structures. One such structure that may be of interest is that of a multilayer degraded by interfacial roughness. ib d...this effect, we attempt in sec. 11-6 to model the complex ISRM process. We refer to the residual kind of thickness error that can occur in such

  19. Passive Seismic Artillery Location by Exact Inverse Scattering,

    DTIC Science & Technology

    1980-07-01

    DOMAIN A VI NUMERICO -EXPERIMENTAL RESULTS 11 VII RECORIMENDATIONS FOR FUTURE RESEARCH 17 VIlI REFERENCES 19 IX APPENDIX: EXACT INVERSE SCATTERING THEORY...these numerico -experimental results, recomnendations for future research are made in section VII. A_ I I SECTION II REFORMULATION OF THE RAYLEIGH...N00014-76-C-0082) in the latter part of this research. This solution was numerico -experimentally verified for a point source and 11 I a point source

  20. Calculations of multiquark functions in effective models of strong interaction

    SciTech Connect

    Jafarov, R. G.; Rochev, V. E.

    2013-09-15

    In this paper we present our results of the investigation of multiquark equations in the Nambu-Jona-Lasinio model with chiral symmetry of SU(2) group in the mean-field expansion. To formulate the mean-field expansion we have used an iteration scheme of solution of the Schwinger-Dyson equations with the fermion bilocal source. We have considered the equations for Green functions of the Nambu-Jona-Lasinio model up to third step for this iteration scheme. To calculate the high-order corrections to the mean-field approximation, we propose the method of the Legendre transformation with respect to the bilocal source, which allows effectively to take into account the symmetry constraints related with the chiral Ward identity. We discuss also the problem of calculating the multiquark functions in the mean-field expansion for Nambu-Jona-Lasinio-type models with other types of the multifermion sources.

  1. Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

    PubMed Central

    Camp, Sara M.; Ceco, Ermelinda; Evenoski, Carrie L.; Danilov, Sergei M.; Zhou, Tong; Chiang, Eddie T.; Moreno-Vinasco, Liliana; Mapes, Brandon; Zhao, Jieling; Gursoy, Gamze; Brown, Mary E.; Adyshev, Djanybek M.; Siddiqui, Shahid S.; Quijada, Hector; Sammani, Saad; Letsiou, Eleftheria; Saadat, Laleh; Yousef, Mohammed; Wang, Ting; Liang, Jie; Garcia, Joe G. N.

    2015-01-01

    Ventilator-induced inflammatory lung injury (VILI) is mechanistically linked to increased NAMPT transcription and circulating levels of nicotinamide phosphoribosyl-transferase (NAMPT/PBEF). Although VILI severity is attenuated by reduced NAMPT/PBEF bioavailability, the precise contribution of NAMPT/PBEF and excessive mechanical stress to VILI pathobiology is unknown. We now report that NAMPT/PBEF induces lung NFκB transcriptional activities and inflammatory injury via direct ligation of Toll–like receptor 4 (TLR4). Computational analysis demonstrated that NAMPT/PBEF and MD-2, a TLR4-binding protein essential for LPS-induced TLR4 activation, share ~30% sequence identity and exhibit striking structural similarity in loop regions critical for MD-2-TLR4 binding. Unlike MD-2, whose TLR4 binding alone is insufficient to initiate TLR4 signaling, NAMPT/PBEF alone produces robust TLR4 activation, likely via a protruding region of NAMPT/PBEF (S402-N412) with structural similarity to LPS. The identification of this unique mode of TLR4 activation by NAMPT/PBEF advances the understanding of innate immunity responses as well as the untoward events associated with mechanical stress-induced lung inflammation. PMID:26272519

  2. High Bias Gas Flows Increase Lung Injury in the Ventilated Preterm Lamb

    PubMed Central

    Bach, Katinka P.; Kuschel, Carl A.; Hooper, Stuart B.; Bertram, Jean; McKnight, Sue; Peachey, Shirley E.; Zahra, Valerie A.; Flecknoe, Sharon J.; Oliver, Mark H.; Wallace, Megan J.; Bloomfield, Frank H.

    2012-01-01

    Background Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI), leading to the development of bronchopulmonary dysplasia (BPD). It is not known whether shear stress injury from gases flowing into the preterm lung during ventilation contributes to VILI. Methods Preterm lambs of 131 days’ gestation (term = 147 d) were ventilated for 2 hours with a bias gas flow of 8 L/min (n = 13), 18 L/min (n = 12) or 28 L/min (n = 14). Physiological parameters were measured continuously and lung injury was assessed by measuring mRNA expression of early injury response genes and by histological analysis. Control lung tissue was collected from unventilated age-matched fetuses. Data were analysed by ANOVA with a Tukey post-hoc test when appropriate. Results High bias gas flows resulted in higher ventilator pressures, shorter inflation times and decreased ventilator efficiency. The rate of rise of inspiratory gas flow was greatest, and pulmonary mRNA levels of the injury markers, EGR1 and CTGF, were highest in lambs ventilated with bias gas flows of 18 L/min. High bias gas flows resulted in increased cellular proliferation and abnormal deposition of elastin, collagen and myofibroblasts in the lung. Conclusions High ventilator bias gas flows resulted in increased lung injury, with up-regulation of acute early response genes and increased histological lung injury. Bias gas flows may, therefore, contribute to VILI and BPD. PMID:23056572

  3. Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury.

    PubMed

    Rizzo, Alicia N; Sammani, Saad; Esquinca, Adilene E; Jacobson, Jeffrey R; Garcia, Joe G N; Letsiou, Eleftheria; Dudek, Steven M

    2015-12-01

    Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), an illness characterized by life-threatening vascular leak, is a significant cause of morbidity and mortality in critically ill patients. Recent preclinical studies and clinical observations have suggested a potential role for the chemotherapeutic agent imatinib in restoring vascular integrity. Our prior work demonstrates differential effects of imatinib in mouse models of ALI, namely attenuation of LPS-induced lung injury but exacerbation of ventilator-induced lung injury (VILI). Because of the critical role of mechanical ventilation in the care of patients with ARDS, in the present study we pursued an assessment of the effectiveness of imatinib in a "two-hit" model of ALI caused by combined LPS and VILI. Imatinib significantly decreased bronchoalveolar lavage protein, total cells, neutrophils, and TNF-α levels in mice exposed to LPS plus VILI, indicating that it attenuates ALI in this clinically relevant model. In subsequent experiments focusing on its protective role in LPS-induced lung injury, imatinib attenuated ALI when given 4 h after LPS, suggesting potential therapeutic effectiveness when given after the onset of injury. Mechanistic studies in mouse lung tissue and human lung endothelial cells revealed that imatinib inhibits LPS-induced NF-κB expression and activation. Overall, these results further characterize the therapeutic potential of imatinib against inflammatory vascular leak.

  4. Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury.

    PubMed

    Seah, Adrian S; Grant, Kara A; Aliyeva, Minara; Allen, Gilman B; Bates, Jason H T

    2011-05-01

    Management of patients with acute lung injury (ALI) rests on achieving a balance between the gas exchanging benefits of mechanical ventilation and the exacerbation of tissue damage in the form of ventilator-induced lung injury (VILI). Optimizing this balance requires an injury cost function relating injury progression to the measurable pressures, flows, and volumes delivered during mechanical ventilation. With this in mind, we mechanically ventilated naive, anesthetized, paralyzed mice for 4 h using either a low or high tidal volume (Vt) with either moderate or zero positive end-expiratory pressure (PEEP). The derecruitability of the lung was assessed every 15 min in terms of the degree of increase in lung elastance occurring over 3 min following a recruitment maneuver. Mice could be safely ventilated for 4 h with either a high Vt or zero PEEP, but when both conditions were applied simultaneously the lung became increasingly unstable, demonstrating worsening injury. We were able to mimic these data using a computational model of dynamic recruitment and derecruitment that simulates the effects of progressively increasing surface tension at the air-liquid interface, suggesting that the VILI in our animal model progressed via a vicious cycle of alveolar leak, degradation of surfactant function, and increasing tissue stress. We thus propose that the task of ventilating the injured lung is usefully understood in terms of the Vt-PEEP plane. Within this plane, non-injurious combinations of Vt and PEEP lie within a "safe region", the boundaries of which shrink as VILI develops.

  5. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury

    PubMed Central

    Spassov, Sashko Georgiev; Donus, Rosa; Ihle, Paul Mikael; Engelstaedter, Helen; Hoetzel, Alexander

    2017-01-01

    The development of ventilator-induced lung injury (VILI) is still a major problem in mechanically ventilated patients. Low dose inhalation of hydrogen sulfide (H2S) during mechanical ventilation has been proven to prevent lung damage by limiting inflammatory responses in rodent models. However, the capacity of H2S to affect oxidative processes in VILI and its underlying molecular signaling pathways remains elusive. In the present study we show that ventilation with moderate tidal volumes of 12 ml/kg for 6 h led to an excessive formation of reactive oxygen species (ROS) in mice lungs which was prevented by supplemental inhalation of 80 parts per million of H2S. In addition, phosphorylation of the signaling protein Akt was induced by H2S. In contrast, inhibition of Akt by LY294002 during ventilation reestablished lung damage, neutrophil influx, and proinflammatory cytokine release despite the presence of H2S. Moreover, the ability of H2S to induce the antioxidant glutathione and to prevent ROS production was reversed in the presence of the Akt inhibitor. Here, we provide the first evidence that H2S-mediated Akt activation is a key step in protection against VILI, suggesting that Akt signaling limits not only inflammatory but also detrimental oxidative processes that promote the development of lung injury. PMID:28250891

  6. Cockroach fauna in the Ogasawara Chain Islands of Japan and analysis of their habitats.

    PubMed

    Komatsu, Noriyuki; Kishimoto, Toshio; Uchida, Akihiko; Ooi, Hong-Kean

    2013-03-01

    A survey of cockroach fauna was carried out on the 3 inhabited islands of the Ogasawara chain island of Japan, namely, Chichijima island, Hahajima island and Iwo island. Seven species, namely, Periplaneta americana (Linnaeus, 1758), Periplaneta australasiae (Fabricius, 1775), Blattella lituricollis (Walker, 1868), Onychostylus vilis (Brunner von Wattenwyl, 1865), Supella longipalpa (Fabricius, 1798), Pycnoscelus surinamensis (Linnaeus, 1758) and Opisthoplatia orientalis (Burmeister, 1838), were collected on Chichijima island. Four species, namely, P. americana, P. australasiae, O. vilis and P. surinamensis were collected on Hahajima island and 6 species, namely, P. americana, P. australasiae, B. lituricollis, O. vilis, P. surinamensis and Neostylopyga rhombifolia were collected on Iwo island. This is the first record of N. rhombifolia and Onychostylus orientalis on the Ogasawara chain islands. Our study increases the recorded taxon of cockroaches on the Ogasawara from 3 families, 5 genera 10 species to 4 families, 7 genera, 12 species. A list of the cockroach species on Ogasawara islands reported to date as well as a key for their identification is also presented. Periplaneta americana and P. australasiae, being the dominant species, together with S. longipalpa, were collected mostly in the indoor environment, indicating their preference for this habitat. Pycnoscelus surinamensis, which is considered as an outdoor insect has been found in semi-household environments such as greenhouse and shed, indicating their new adaptation to the changing environment.

  7. [Renowned scientist, pedagogue, and physician dedicated to the memory of the 110th anniversary of Bronius Sidaravicius's birth].

    PubMed

    Laurynaityte, Gryta; Lignugariene, Asta; Valiukeviciene, Skaidra

    2007-01-01

    This year we celebrate the 110th anniversary of Bronius Sidaravicius's (1897-1969) birth. He was a renowned Lithuanian dermato-venereologist, professor, head of the Department of Skin and Venereal Diseases at Vytautas Magnus University (1935-1946, 1956-1969), the founder and the chair of the Lithuanian Society of Dermato-venereologists, coeditor of the prewar journal "Medicina." He is an author of more than 100 articles and the very first course book on dermato-venereology in Lithuanian. He completed a part of his medical studies at universities in Germany. In Vienna University (1930), B. Sidaravicius performed clinical and experimental studies on the passive transmission of skin allergy, which had a major impact on the diagnostics of allergic skin diseases and specific desensibilization. He published the results of his study in the foreign literature and in the doctoral dissertation "Skin allergy and its treatment" in 1931. Thanks to the efforts of B. Sidaravicius and his colleagues, a progressive Law on Control and Prevention of Venereal Diseases was enacted in Lithuania. According to this Law, examinations and treatment of venereal diseases became compulsory and free of charge at state- or municipality-financed venereal outpatient units. This article was prepared on the basis of primary sources: protocols of the Council (the Faculty of Medicine, the University of Lithuania; since 1930 - Vytautas Magnus University) kept at the Museum of the History of Lithuania Medicine and Pharmacy as well as documents preserved at the Lithuanian State Archives and also scientific journals and periodicals both in Lithuanian and foreign languages.

  8. 77 FR 43350 - Draft Environmental Assessment and Proposed Habitat Conservation Plan for the San Diego Unified...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... San Diego Unified School District's Jonas Salk Elementary School Project in the City of San Diego, San... Elementary School Project in response to an application from the San Diego Unified School District (District... Elementary School'' in the subject line of the message. Fax: Attn: Jim Bartel, Field Supervisor, (760)...

  9. Proceedings of the 1990 Annual Meeting of the Association for Education in Journalism and Mass Communication (73rd, Minneapolis, Minnesota, August 1-4, 1990). Part VI: Foreign and International Media Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The foreign and international media studies section of the proceedings includes the following 11 papers: "The Contemporary Pacific Islands Press" (Suzanna Layton); "Cultural Domination and Sovereignty: The Development of European TV Quotas, 1981-89" (Ulf Jonas Bjork); "A Content Analysis of TV News in Saudi Arabia and…

  10. Hepatitis C -- children

    MedlinePlus

    ... children; HCV children; Pregnancy - hepatitis C - children; Maternal transmission - hepatitis C - children References Elisofon SA, Jonas MMF. ... Hospital, Hollywood, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David ... this important distinction for online health information and services. Learn more about A.D.A. ...

  11. Precision Control and Randomized Benchmarking of a 12-us Class Superconducting Qubit

    DTIC Science & Technology

    2013-03-28

    2012 2.00 David Cory, Jonas Bylander, Fei Yan, Simon Gustavsson, Fumiki Yoshihara, Khalil Harrabi, Terry Orlando, Yasunobu Nakamura, Jaw-Shen Tsai...spectroscopy through dynamical decoupling with a superconducting flux qubit” viii. Seminar: Chalmers University of Technology, Gothenburg, Sweden, September

  12. A User-Centered Approach to the Design of an Expert System for Training.

    ERIC Educational Resources Information Center

    Borges, Marcos Augusto Francisco; Baranauskas, M. Cecilia C.

    1998-01-01

    Reports on a research project designed to develop an intelligent computer-based learning environment of industrial applications. "Jonas," an expert system, is part of a modeling/simulation environment which enables shop-floor workers to test and put new philosophies of work into practice in the context of manufacture. The approach focuses on the…

  13. Aspects of the strongly interacting matter phase diagram within non-local quark models

    SciTech Connect

    Pagura, V.; Dumm, D. G.; Scoccola, N. N.

    2013-03-25

    We study a nonlocal extension of the so-called Polyakov Nambu-Jona-Lasinio model at finite temperature and chemical potential, considering the impact of the presence of dynamical quarks on the scale parameter appearing in the Polyakov potential. Both real and imaginary chemical potentials are considered. The effect of varying the current quark mass is also investigated.

  14. Finland’s Security Solution in the Future

    DTIC Science & Technology

    2013-03-01

    humanitarian assistance, and greatest source of international norms and standards. Despite the rise of the BRIC countries (Brazil, Russia, India and China...developments", said the Norwegian Foreign Minister Jonas Gahr Støre.50 According to the Program of Government, defense, science and innovation policies, as

  15. Toward a Communication Theory Focused on Humankind's Future.

    ERIC Educational Resources Information Center

    Ternent, William A.; Ternent, Janet A.

    This speech presents a model of human communication which integrates the existential philosophy of Martin Buber with the communication views of Jonas Salk. In his book, "The Survival of the Wisest," Salk characterizes an "Epoch A" to describe the values and behaviors of the past and an "Epoch B" to describe the necessary values and behaviors for…

  16. Foundational Studies in Teacher Education: A Reexamination. Special Issues from the Teachers College Record.

    ERIC Educational Resources Information Center

    Tozer, Steven, Ed.; Anderson, Thomas H., Ed.; Armbruster, Bonnie B., Ed.

    This collection of essays focuses on the role of psychological and cultural foundations in teacher education. Following an introduction by the editors, the 12 essays are as follows: "Reconnecting Foundations to the Substance of Teacher Education" (Lee S. Shulman); "A Reconceptualization of Educational Foundations" (Jonas F.…

  17. Vietnam Head Injury Study - Phase III: A 30-Year Post-Injury Follow-Up Study

    DTIC Science & Technology

    2007-08-01

    1500-1502. Grafman J, Jonas BS, Martin A, Salazar AM, Weingartner H, Ludlow C, Smutok MA, Vance SC,: Intellectual function following penetrating...Press, Oxford, 2000) - 81 - 14. Eichenbaum , H. A cortical-hippocampal system for declarative memory. Nat. Rev. Neurosci. 1, 41-50 (2000). 15

  18. Gluon condensate in a pion superfluid beyond the mean-field approximation

    SciTech Connect

    Jiang Yin; Zhuang Pengfei

    2011-03-15

    We study gluon condensate in a pion superfluid by calculating the equation of state of the system in the Nambu-Jona-Lasinio model. While in mean-field approximation the growing pion condensate leads to an increasing gluon condensate, meson fluctuations reduce the gluon condensate, and the broken scalar symmetry can be smoothly restored at finite isospin density.

  19. A Unified Theory of Penetration

    DTIC Science & Technology

    1986-12-01

    in High-velocity Impact Phenomena, Ed. by R. Kinslow (New York, Academic F. ess, 1970). 3.7 J. S. Rinehart and J. Pearson, Behavior of Metals under...Rosset L. Magness A. Dietrich J. Zook G. Moss R. Frey H. Jonas W. Bruchey J. Zukas "G. Hauver K. Frank T. Wright G. Silsby A. Finnerty A. Kurian J. Polk

  20. Making Lipid Membranes Rough, Tough, and Ready to Hit the Road

    DTIC Science & Technology

    2006-07-01

    come into contact with the surface with long-term use. Besides biofouling, solid- supported bilayers can be easily ruined when contaminated with common ...Baumgart, U. Jonas, A. Offenhäusser, and W. Knoll, Langmuir 18 (2002) p. 4082. 30. T. Petralli- Mallow , K.A. Brigmann, L.J. Richter, J.C. Stephenson

  1. Three Misunderstandings of Plato's Theory of Moral Education

    ERIC Educational Resources Information Center

    Jonas, Mark E.

    2016-01-01

    In this essay, Mark Jonas argues that there are three broadly held misconceptions of Plato's philosophy that work against his relevance for contemporary moral education. The first is that he is an intellectualist who is concerned only with the cognitive aspect of moral development and does not sufficiently emphasize the affective and conative…

  2. Ben Jonson: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Barish, Jonas A., Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Jonas A. Barish, T. S. Eliot, L. C. Knights, Harry Levin, Edmund Wilson, Arthur Sale, C. H. Herford, Paul Goodman, Edward B. Partridge, Ray L. Heffner, Jr., Joseph Allen Bryant, Jr., and Dolora Cunningham--all dealing…

  3. Reflection makes sense of rotation of the eyes.

    PubMed

    Judge, S J

    2006-10-01

    Our 3-D percept of the world is constructed from the two-dimensional visual images on the retina of each eye, but these images and the relationships between them are affected by the 3-D rotations of each eye. These 3-D eye rotations are constrained to patterns such as Listing's law, or its generalisation 'L2', according to the context. Our understanding of the patterns of such three-dimensional eye rotations, and their effect on the retinal images, has been greatly advanced by the development of algebraic methods (Haustein, 1989; Tweed & Vilis, 1987; Westheimer, 1957) for calculating the effect of eye rotations. But not many would say, with Dirac, that they understand the equations describing the 3-D geometry in the sense that they have "a way of figuring out the characteristic of its solution without actually solving it" (Dirac, according to Feynman, Leighton, & Sands, 1964). I show here how the geometry of 3-D rotations of the eye and their visual effects can be made easier to understand by use of the principle that a rotation through angle alpha can be achieved by a pair of reflections in planes with an angular separation alpha/2, and a common line that is the rotation axis (Tweed, 1997b; Tweed, Cadera, & Vilis, 1990). Mathematically (see Appendix A), the method is equivalent to decomposing the unit quaternions so successfully used to study three-dimensional eye rotations (Tweed & Vilis, 1987; Westheimer, 1957) into pairs of pure quaternions (ones whose scalar part is zero) which represent the reflections (Coxeter, 1946).

  4. The NAMPT Promoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

    PubMed Central

    Sun, Xiaoguang; Elangovan, Venkateswaran Ramamoorthi; Mapes, Brandon; Camp, Sara M.; Sammani, Saad; Saadat, Laleh; Ceco, Ermelinda; Ma, Shwu-Fan; Flores, Carlos; MacDougall, Matthew S.; Quijada, Hector; Liu, Bin; Kempf, Carrie L.; Wang, Ting; Chiang, Eddie T.

    2014-01-01

    Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mechanical stress remain poorly understood. The objective of this study was to define the contribution of specific transcription factors, acute respiratory distress syndrome (ARDS)-associated single nucleotide polymorphisms (SNPs), and promoter demethylation to NAMPT transcriptional regulation in response to mechanical stress. In vivo NAMPT protein expression levels were examined in mice exposed to high tidal volume mechanical ventilation. In vitro NAMPT expression levels were examined in human pulmonary artery endothelial cells exposed to 5 or 18% cyclic stretch (CS), with NAMPT promoter activity assessed using NAMPT promoter luciferase reporter constructs with a series of nested deletions. In vitro NAMPT transcriptional regulation was further characterized by measuring luciferase activity, DNA demethylation, and chromatin immunoprecipitation. VILI-challenged mice exhibited significantly increased NAMPT expression in bronchoalveolar lavage leukocytes and in lung endothelium. A mechanical stress–inducible region (MSIR) was identified in the NAMPT promoter from −2,428 to −2,128 bp. This MSIR regulates NAMPT promoter activity, mRNA expression, and signal transducer and activator of transcription 5 (STAT5) binding, which is significantly increased by 18% CS. In addition, NAMPT promoter activity was increased by pharmacologic promoter demethylation and inhibited by STAT5 silencing. ARDS-associated NAMPT promoter SNPs rs59744560 (−948G/T) and rs7789066 (−2,422A/G) each significantly elevated NAMPT promoter activity in response to 18% CS in a STAT5-dependent manner. Our results show that NAMPT is a key novel ARDS therapeutic target and candidate gene with genetic

  5. Integrating microRNAs into a system biology approach to acute lung injury.

    PubMed

    Zhou, Tong; Garcia, Joe G N; Zhang, Wei

    2011-04-01

    Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various genetic and nongenetic factors. Using the candidate gene approach, genetic variants associated with immune response and inflammatory pathways have been identified and implicated in ALI. Because gene expression is an intermediate phenotype that resides between the DNA sequence variation and the higher level cellular or whole-body phenotypes, the illustration of gene expression regulatory networks potentially could enhance understanding of disease susceptibility and the development of inflammatory lung syndromes. MicroRNAs (miRNAs) have emerged as a novel class of gene regulators that play critical roles in complex diseases including ALI. Comparisons of global miRNA profiles in animal models of ALI and VILI identified several miRNAs (eg, miR-146a and miR-155) previously implicated in immune response and inflammatory pathways. Therefore, via regulation of target genes in these biological processes and pathways, miRNAs potentially contribute to the development of ALI. Although this line of inquiry exists at a nascent stage, miRNAs have the potential to be critical components of a comprehensive model for inflammatory lung disease built by a systems biology approach that integrates genetic, genomic, proteomic, epigenetic as well as environmental stimuli information. Given their particularly recognized role in regulation of immune and inflammatory responses, miRNAs also serve as novel therapeutic targets and biomarkers for ALI/ARDS or VILI, thus facilitating the realization of personalized medicine for individuals with acute inflammatory lung disease.

  6. Image Analysis Program for Measuring Particles with the Zeiss CSM 950 Scanning Electron Microscope (SEM)

    DTIC Science & Technology

    1990-01-01

    7 𔄁 . ,: 1& *U _’ ś TECHNICAL REPORT AD NATICK/TR-90/014 (V) N* IMAGE ANALYSIS PROGRAM FOR MEASURING PARTICLES < WITH THE ZEISS CSM 950 SCANNING... image analysis program for measuring particles using the Zeiss CSM 950/Kontron system is as follows: A>CSM calls the image analysis program. Press D to...27 vili LIST OF TABLES TABLE PAGE 1. Image Analysis Program for Measuring 29 Spherical Particles 14 2. Printout of Statistical Data Frcm Table 1 16 3

  7. Paediatric lung recruitment: a review of the clinical evidence.

    PubMed

    Jauncey-Cooke, Jacqui; East, Chris E; Bogossian, Fiona

    2015-03-01

    Lung recruitment is used as an adjunct to lung protective ventilation strategies. Lung recruitment is a brief, deliberate elevation of transpulmonary pressures beyond what is achieved during tidal ventilation levels. The aim of lung recruitment is to maximise the number of alveoli participating in gas exchange particularly in distal and dependant regions of the lung. This may improve oxygenation and end expiratory levels. Restoration of end expiratory levels and stabilisation of the alveoli may reduce the incidence of ventilator induced lung injury (VILI). Various methods of lung recruitment have been studied in adult and experimental populations. This review aims to establish the evidence for lung recruitment in the pediatric population.

  8. Portrait

    PubMed Central

    Granoff, Dan M.

    2013-01-01

    Born in 1944, I grew up in a world in which polio was both a gripping fear and real threat. Then in a matter of a few years—polio was eradicated by a vaccine developed by Jonas Salk. Later I learned that Salk’s efforts were built on pioneering work of many others, including John Enders, Thomas Weller and Frederick Robbins (Nobelists, 1954), and David Bodian, who pioneered studies of polio pathogenesis and immunity. Bodian became my teacher in medical school, and Robbins became a colleague. Later, Salk, Robbins and I shared a platform at an infectious diseases symposium, and I was privileged to speak at Robbins’ retirement. But that gets ahead of my story. In January 1956, at age 12 y, I received my first of dose of the “Salk” vaccine. Other kids had pictures of athletes in their rooms; I had a picture of Jonas Salk. PMID:23807081

  9. Phase diagram of quark-antiquark and diquark condensates in the 3-dimensional Gross-Neveu model with the 4-component spinor representation

    SciTech Connect

    Kohyama, Hiroaki

    2008-07-01

    We construct the phase diagram of the quark-antiquark and diquark condensates at finite temperature and density in the 2+1 dimensional (3D) two flavor massless Gross-Neveu (GN) model with the 4-component quarks. In contrast to the case of the 2-component quarks, there appears the coexisting phase of the quark-antiquark and diquark condensates. This is the crucial difference between the 2-component and 4-component quark cases in the 3D GN model. The coexisting phase is also seen in the 4D Nambu Jona-Lasinio model. Then we see that the 3D GN model with the 4-component quarks bears closer resemblance to the 4D Nambu Jona-Lasinio model.

  10. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

    PubMed Central

    Tao, Shasha; Rojo de la Vega, Montserrat; Quijada, Hector; Wondrak, Georg T.; Wang, Ting; Garcia, Joe G. N.; Zhang, Donna D.

    2016-01-01

    Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due to lung edema, trauma, or general anesthesia. However, MV causes ventilator-induced lung injury (VILI), a condition characterized by increased permeability of the alveolar-capillary barrier that results in edema, hemorrhage, and neutrophil infiltration, leading to exacerbated lung inflammation and oxidative stress. This study explored the feasibility of using bixin, a canonical NRF2 inducer identified during the current study, to ameliorate lung damage in a murine VILI model. In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo. Remarkably, IP administration of bixin restored normal lung morphology and attenuated inflammatory response and oxidative DNA damage following MV. This observed beneficial effect of bixin derived from induction of the NRF2 cytoprotective response since it was only observed in Nrf2+/+ but not in Nrf2−/− mice. This is the first study providing proof-of-concept that NRF2 activators can be developed into pharmacological agents for clinical use to prevent patients from lung injury during MV treatment. PMID:26729554

  11. Genetic Targets of Hydrogen Sulfide in Ventilator-Induced Lung Injury – A Microarray Study

    PubMed Central

    Spassov, Sashko; Pfeifer, Dietmar; Strosing, Karl; Ryter, Stefan; Hummel, Matthias; Faller, Simone; Hoetzel, Alexander

    2014-01-01

    Recently, we have shown that inhalation of hydrogen sulfide (H2S) protects against ventilator-induced lung injury (VILI). In the present study, we aimed to determine the underlying molecular mechanisms of H2S-dependent lung protection by analyzing gene expression profiles in mice. C57BL/6 mice were subjected to spontaneous breathing or mechanical ventilation in the absence or presence of H2S (80 parts per million). Gene expression profiles were determined by microarray, sqRT-PCR and Western Blot analyses. The association of Atf3 in protection against VILI was confirmed with a Vivo-Morpholino knockout model. Mechanical ventilation caused a significant lung inflammation and damage that was prevented in the presence of H2S. Mechanical ventilation favoured the expression of genes involved in inflammation, leukocyte activation and chemotaxis. In contrast, ventilation with H2S activated genes involved in extracellular matrix remodelling, angiogenesis, inhibition of apoptosis, and inflammation. Amongst others, H2S administration induced Atf3, an anti-inflammatory and anti-apoptotic regulator. Morpholino mediated reduction of Atf3 resulted in elevated lung injury despite the presence of H2S. In conclusion, lung protection by H2S during mechanical ventilation is associated with down-regulation of genes related to oxidative stress and inflammation and up-regulation of anti-apoptotic and anti-inflammatory genes. Here we show that Atf3 is clearly involved in H2S mediated protection. PMID:25025333

  12. An approach to ventilation in acute respiratory distress syndrome

    PubMed Central

    Houston, Patricia

    2000-01-01

    Appropriate management of patients with acute respiratory distress syndrome (ARDS) represents a challenge for physicians working in the critical care environment. Significant advances have been made in understanding the pathophysiology of ARDS. There is also an increasing appreciation of the role of ventilator-induced lung injury (VILI). VILI is most likely related to several different aspects of ventilator management: barotrauma due to high peak airway pressures, lung overdistension or volutrauma due to high transpulmonary pressures, alveolar membrane damage due to insufficient positive end-expiratory pressure levels and oxygen-related cell toxicity. Various lung protective strategies have been suggested to minimize the damage caused by conventional modes of ventilation. These include the use of pressure- and volume-limited ventilation, the use of the prone position in the management of ARDS, and extracorporeal methods of oxygen delivery and carbon dioxide removal. Although the death rate resulting from ARDS has been declining over the past 10 years, there is no evidence that any specific treatment or change in approach to ventilation is the cause of this improved survival. PMID:10948686

  13. Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies.

    PubMed

    Hopster, K; Jacobson, B; Hopster-Iversen, C; Rohn, K; Kästner, S B R

    2016-08-01

    Inappropriate mechanical ventilation can lead to ventilator-induced lung injury (VILI). Aim of this study was to evaluate the effects of inhalation anaesthesia and ventilation with and without recruitment (RM) and PEEP titration on alveolar integrity in horses. Twenty-three horses were divided into 4 groups (group OLC ventilated with OLC, group IPPV ventilated with intermittent positive pressure ventilation, group NV non-ventilated, and group C non-anaesthetized control group). After sedation with xylazine and induction with diazepam and ketamine anaesthetized horses were under isoflurane anaesthesia for 5.5h. The horses were euthanized and tissue samples of the dependent and non-dependent lung areas were collected. Histopathological examinations of the lung tissue as well as relative quantification of mRNA of IL-1β, IL-6, iNOS, MMP1 and MMP9 by PCR were performed. Horses of group OLC had significantly less alveolar congestion and atelectasis but greater alveolar overdistension compared to groups NV and IPPV. In groups OLC and group IPPV an increase in IL-1β/6 and MMP1/9 was detected compared to groups NV and C. In conclusion, in breathing spontaneously or IPPV-ventilated horses a higher degree of atelectasis was detected, whereas in OLC-ventilated horses a higher degree of overdistention was present. Elevated levels in IL and MMP might be early signs of VILI in ventilated horses.

  14. Quark matter under strong magnetic fields in chiral models

    SciTech Connect

    Rabhi, Aziz; Providencia, Constanca

    2011-05-15

    The chiral model is used to describe quark matter under strong magnetic fields and is compared to other models, the MIT bag model and the two-flavor Nambu-Jona-Lasinio model. The effect of vacuum corrections due to the magnetic field is discussed. It is shown that if the magnetic-field vacuum corrections are not taken into account explicitly, the parameters of the models should be fitted to low-density meson properties in the presence of the magnetic field.

  15. Fluids, Gels and Glasses Under Extreme Conditions of Pressure and Temperature

    DTIC Science & Technology

    1989-02-17

    some borosiloxane (=B-O-Si ) linkages are formed in solution, their concentration dimin- ishes toward gelation due to re-hydrolysis to form boric acid ...Borosilo- xane units are not stable in these solutions containing excess water and alcohol. The boric acid does, however, condense to form...Polymerization Processes in Acid and Base Catalyzed Silica Sol-Gels," T. W. Zerda, I. Artaki and J. Jonas, J. Non-Crystalline Sol- ids, 81, 365 (1986

  16. Evaluation of Chemical and Atmospheric Sciences Research

    DTIC Science & Technology

    1984-09-09

    I Geil 48 Benesch 49 Niedenzu B/B+ 1 Marchand 26 El Batouay 9 Tuazon B 24 Maddou 33 Thompson23 Winefordner 21) Lauer 30) Me-’nzer 0’ SalK 7 Lin C 28...APOSR CHEMISTRY RESEARCH- EVALUATION CATE3GORY I CATEGORY TI A+36 Jonas 43 Field A 06 Hubbard 25 Williams 29 Bernstein 24 Smalley 19 Winograd * 14 Rice

  17. Findings of VA/DoD CPG on CAM Therapies for PTSD

    DTIC Science & Technology

    2011-01-26

    post ES 1.4-1.6 versus usual care ES 0.12-0.74 Depression and pain symptoms Mental but not physical health functioning VA/DoD PTSD CPG...The Quadruple Aim: Working Together, Achieving Success 2011 Military Health System Conference Defense Centers of Excellence for Psychological Health ...Elizabeth Harper Cordova, M.A., Wayne Jonas, M.D. 1 Military Health System Conference Report Documentation Page Form ApprovedOMB No. 0704-0188 Public

  18. JPRS Report, West Europe.

    DTIC Science & Technology

    2007-11-02

    new Landsting, which now has been elected, is composed as follows: Southern Area: SIÜMÜT: Jonathan Motzfeldt and Hendrik Nielsen . ATASSUT: Peter...ATASSUT: Jakob Sivertsen. Ittoqqortoormi it: SIUMUT: Jonas Danielsen. About the election figures it can be said that Atassut has regained the role...Committee was on the agenda right after the establishment of the government. Dp to now the committee has consisted of Preben Lange and Pavia Nielsen

  19. Alternate Propulsion Energy Sources.

    DTIC Science & Technology

    1983-06-01

    sails, laser propulsion , tethers, fusion rockets, antimatter rockets Z9 BSTRACT (Continue on reverse aide if necessary and identify by block number) This...advanced propulsion Dr. Robert Frisbee, JPL - advanced propulsion Dr. Jonas Zmuidzinas, JPL - metastable helium Dr. Paul Massier, JPL - antimatter ... propulsion Dr. Duane Dipprey, JPL - antimatter propulsion Dr. Giulio Varsi, JPL - solar sails Dr. William Carroll, JPL - solar sails Dr. Duncan Steel

  20. Two-Loop Effective Action for Theories with Fermions

    NASA Astrophysics Data System (ADS)

    Faizullaev, B. A.; Musakhanov, M. M.

    1995-08-01

    On the basis of a new approach for the calculation of the effective action developed in our previous works we calculate the effective action (up to two-loop level) for some models containing fermion fields. This method allows us to calculate the fermionic part of the effective action properly. The two-loop contribution to the effective potential for the Nambu-Jona-Lasinio model is calculated and is shown to vanish.

  1. Anomalous diffraction approximation limits

    NASA Astrophysics Data System (ADS)

    Videen, Gorden; Chýlek, Petr

    It has been reported in a recent article [Liu, C., Jonas, P.R., Saunders, C.P.R., 1996. Accuracy of the anomalous diffraction approximation to light scattering by column-like ice crystals. Atmos. Res., 41, pp. 63-69] that the anomalous diffraction approximation (ADA) accuracy does not depend on particle refractive index, but instead is dependent on the particle size parameter. Since this is at odds with previous research, we thought these results warranted further discussion.

  2. Combat Analysis of Advanced Technology Weapons Concepts

    DTIC Science & Technology

    2007-11-02

    determined from equations summarized in "High Velocity Impact Dynamics" by Dr. Jonas Zukas These equations are derived by assuming that non-deforming...damage rating, whether or not the impact creates spall, and the projectile’s damage properties. Additional calculations are performed to determine special... impact of a projectile (or sub projectile) or blast wave on the target. Instead, these weapons cause destruction by overloading specific components of

  3. Nucleon quark distributions in a covariant quark-diquark model

    SciTech Connect

    Ian Cloet; W. Bentz; Anthony Thomas

    2005-04-01

    Spin-dependent and spin-independent quark light-cone momentum distributions and structure functions are calculated for the nucleon. We utilize a modified Nambu-Jona-Lasinio model in which confinement is simulated by eliminating unphysical thresholds for nucleon decay into quarks. The nucleon bound state is obtained by solving the Faddeev equation in the quark-diquark approximation, where both scalar and axial-vector diquarks channels are included. We find excellent agreement between our model results and empirical data.

  4. Acupuncture in Military Medicine

    DTIC Science & Technology

    2013-01-01

    scalable to a large population. The Samueli Institute is currently testing the effectiveness of this standardized approach compared to a more holistic...is supported by the U.S. Army Medical Research and Materiel Com‐ mand under Award No. W81XWH-06-1-0279 to Samueli Institute. The views, opinions and...Niemtzow2 and Wayne B. Jonas1 1 Samueli Institute, USA 2 United States Air Force Acupuncture Center, Joint Base Andrews, USA References [1] CDC

  5. Assessment of Chiropractic Treatment for Low Back Pain, Military Readiness and Smoking Cessation in Military Active Duty Personnel

    DTIC Science & Technology

    2013-03-01

    System; Wayne B. Jonas, M.D. of Samueli Institute; Anthony J. Lisi, DC of Veterans Health Administration; Dennis Marchiori, DC, Ph.D. of Palmer...received official signatures from: WRNMMC, Samueli Institute, Palmer College of Chiropractic and RAND Corporation and San Diego Commanding Admiral, who...review. Once an IT Impact Statement is obtained from WRNMMC the amendment will be sent for legal review. Samueli Institute is in the process of

  6. Acupuncture in Military Medicine

    DTIC Science & Technology

    2013-01-01

    large population. The Samueli Institute is currently testing the effectiveness of this standardized approach compared to a more holistic acupuncture...supported by the U.S. Army Medical Research and Materiel Com‐ mand under Award No. W81XWH-06-1-0279 to Samueli Institute. The views, opinions and/or findings...and Wayne B. Jonas1 1 Samueli Institute, USA 2 United States Air Force Acupuncture Center, Joint Base Andrews, USA References [1] CDC National Center

  7. Center for Evaluation of Resilience Programs

    DTIC Science & Technology

    2014-10-14

    PRINCIPAL INVESTIGATOR: Wayne Jonas, MD CONTRACTING ORGANIZATION: Samueli ...7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Samueli Institute 8. PERFORMING ORGANIZATION REPORT NUMBER Alexandria, VA 22314... Samueli  Institute  PROJECT TITLE:  Central Evaluation of Resilience Programs (CERP)      ©2014 Samueli  Institute Yearly Report, W81XWH-11-2-0173| 14

  8. Assessment of Chiropractic Treatment for Low Back Pain, Military Readiness and Smoking Cessation in Military Active Duty Personnel

    DTIC Science & Technology

    2012-03-01

    Johnson, DC of VAGLA Healthcare System; Wayne B. Jonas, M.D. of Samueli Institute; Anthony J. Lisi, DC of Veterans Health Annual Report, W81XWH-11-2...concerns are minimal. After the first of the year, COL Helwig and Dr. Mona Bingham ( Samueli Institute) will begin working on the necessary documentation to...RAND’s marketing department, Samueli Institute’s marketing department, Palmer Center for Chiropractic Research employees and chiropractors working in

  9. What are the Ethical Problems Raised by the Increase of Cognitive Capabilities in the Defence Structure: The French Legal Structure, the Ethical Position of the French Military Health Service

    DTIC Science & Technology

    2009-10-01

    principles for conducting research on humans as animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some modifications...ethical principles for conducting research on humans as animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some...partly, to the doctors and it had become necessary to think of the power of man outside of medicine. According to the German Hans Jonas “ bioethics

  10. From inverse to delayed magnetic catalysis in a strong magnetic field

    NASA Astrophysics Data System (ADS)

    Mao, Shijun

    2016-08-01

    We study the magnetic field effect on chiral phase transition in a Nambu-Jona-Lasinio model. In comparison with a mean-field approximation containing only quarks, including mesons as quantum fluctuations in the model leads to a transition from inverse to delayed magnetic catalysis at finite temperature and delays the transition at finite baryon chemical potential. The location of the critical end point depends nonmonotonically on the magnetic field.

  11. Auricular Therapy for Treatment of Musculoskeletal Pain in the Setting of Military Personnel: A Randomized Trial

    DTIC Science & Technology

    2012-10-01

    addition of a specific auricular therapy protocol to standard care will have a beneficial impact on the pain and functionality of subjects who sustain...changes, etc) than usual care; c) more rapid and significant return of functional ability than usual care; and d) more rapid and significant reduction...Goertz CM, Niemtzow R, Burns SM, Fritts MJ, Crawford CC, Jonas WB. Auricular acupuncture in the treatment of acute pain syndromes: A pilot study. Mil Med

  12. Quark confinement in a constituent quark model

    SciTech Connect

    Langfeld, K.; Rho, M.

    1995-07-01

    On the level of an effective quark theory, we define confinement by the absence of quark anti-quark thresholds in correlation function. We then propose a confining Nambu-Jona-Lasinio-type model. The confinement is implemented in analogy to Anderson localization in condensed matter systems. We study the model`s phase structure as well as its behavior under extreme conditions, i.e. high temperature and/or high density.

  13. Achieving Adaptability through Inquiry Based Learning

    DTIC Science & Technology

    2010-06-01

    knowledge. IBL is based on a different conception of learning, one traceable back to John Dewey (1910) and Jean Piaget (1972; von Glasersfeld, 1995) and...Dewey, 1910; Duffy 2009; Piaget , 1972; Schank, Fano, Bell, and Jona, 1993). If the learners are focused on figuring out what the instructor wants...errors or the inability to fully make sense of a situation provides the basis for learning ( Piaget , 1973; Schank, et al, 1993). Thus the errors

  14. Acquisition of Oceanographic Measurements from Baleen Whales: Field Deployments of Tags Developed Under Grant ONR (N00014-13-1-0854)

    DTIC Science & Technology

    2014-09-30

    Whales : Field Deployments of Tags Developed Under Grant ONR (N00014-13-1-0854) Jonas Teilmann Department of Bioscience University of Aarhus...LONG-TERM GOALS To use large baleen whales as oceanographic sampling platforms and understand how they use oceanographic features to navigate...and find prey. OBJECTIVES • To develop CTD satellite transmitters for baleen whales that can collect and transmit data on location, depth

  15. The influence of meteorological factors on growth and vegetation process of Perilla frutescens (L.) Britton in Lithuania.

    PubMed

    Ragazinskiene, Ona; Seinauskiene, Erika; Janulis, Valdimaras; Jankauskaite, Lina; Milasius, Arvydas

    2006-01-01

    The results of a study on the dependence of growth and vegetation process of Perilla frutescens (L.) Britton upon meteorological factors are presented in the article. The investigations were conducted at Kaunas Botanical Garden of Vytautas Magnus University during vegetation periods in 2001-2005. The object of investigations was Perilla frutescens (L.) Britton, a medicinal annual herbaceous plant of Lamiaceae Lindl. family, native of Eastern Asia, which passes the whole development cycle under climatic conditions of Central Lithuania. The duration of vegetation period of Perilla frutescens on the average is 167 days. The earliest beginning of vegetation and optimal climatic conditions for growth are when hydrothermic coefficient reaches 1.60-1.80 (conditions of excessive humidity). Optimal climatic conditions for massive flowering and seed maturation are observed when hydrothermic coefficient decreases to 1.20 - then massive flowering starts 10 days earlier and lasts 25 days longer. A strong correlation was found between massive flowering and hydrothermic coefficient (r(2)=0.9408). Using mathematical-statistical methods, the consistent patterns of growth and vegetation process of Perilla frutescens (L.) Britton were determined, specifying the time for raw material preparation what determines its quality and quantity.

  16. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

    PubMed

    Henriques, Isabela; Padilha, Gisele A; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J B; Ramos, Isalira P; Rocha, Nazareth; Cruz, Fernanda F; Santos, Raquel S; de Oliveira, Milena V; Souza, Sergio A; Goldenberg, Regina C; Luiz, Ronir R; Pelosi, Paolo; de Abreu, Marcelo G; Silva, Pedro L; Rocco, Patricia R M

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  17. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

    NASA Astrophysics Data System (ADS)

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F.; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  18. Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema

    PubMed Central

    Henriques, Isabela; Padilha, Gisele A.; Huhle, Robert; Wierzchon, Caio; Miranda, Paulo J. B.; Ramos, Isalira P.; Rocha, Nazareth; Cruz, Fernanda F.; Santos, Raquel S.; de Oliveira, Milena V.; Souza, Sergio A.; Goldenberg, Regina C.; Luiz, Ronir R.; Pelosi, Paolo; de Abreu, Marcelo G.; Silva, Pedro L.; Rocco, Patricia R. M.

    2016-01-01

    Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into two protocols: (1) characterization of an elastase-induced emphysema model in rats and identification of the time point of greatest cardiorespiratory impairment, defined as a high specific lung elastance associated with large right ventricular end-diastolic area; and (2) comparison between variable (VV) and conventional volume-controlled ventilation (VCV) on lung mechanics and morphometry, biological markers, and cardiac function at that time point. In the first protocol, Wistar rats (n = 62) received saline (SAL) or porcine pancreatic elastase (ELA) intratracheally once weekly for 4 weeks, respectively. Evaluations were performed 1, 3, 5, or 8 weeks after the last intratracheal instillation of saline or elastase. After identifying the time point of greatest cardiorespiratory impairment, an additional 32 Wistar rats were randomized into the SAL and ELA groups and then ventilated with VV or VCV (n = 8/group) [tidal volume (VT) = 6 mL/kg, positive end-expiratory pressure (PEEP) = 3 cmH2O, fraction of inspired oxygen (FiO2) = 0.4] for 2 h. VV was applied on a breath-to-breath basis as a sequence of randomly generated VT values (mean VT = 6 mL/kg), with a 30% coefficient of variation. Non-ventilated (NV) SAL and ELA animals were used for molecular biology analysis. The time point of greatest cardiorespiratory impairment, was observed 5 weeks after the last elastase instillation. At this time point, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant (CINC)-1, amphiregulin, angiopoietin (Ang)-2, and vascular endothelial growth factor (VEGF) mRNA levels were higher in ELA compared to SAL. In ELA animals

  19. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome.

    PubMed

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  20. Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India.

    PubMed

    Arbyn, Marc; Sankaranarayanan, Rengaswamy; Muwonge, Richard; Keita, Namory; Dolo, Amadou; Mbalawa, Charles Gombe; Nouhou, Hassan; Sakande, Boblewende; Wesley, Ramani; Somanathan, Thara; Sharma, Anjali; Shastri, Surendra; Basu, Parthasarathy

    2008-07-01

    Cervical cancer is the main cancer among women in sub-Saharan Africa, India and other parts of the developing world. Evaluation of screening performance of effective, feasible and affordable early detection and management methods is a public health priority. Five screening methods, naked eye visual inspection of the cervix uteri after application of diluted acetic acid (VIA), or Lugol's iodine (VILI) or with a magnifying device (VIAM), the Pap smear and human papillomavirus testing with the high-risk probe of the Hybrid Capture-2 assay (HC2), were evaluated in 11 studies in India and Africa. More than 58,000 women, aged 25-64 years, were tested with 2-5 screening tests and outcome verification was done on all women independent of the screen test results. The outcome was presence or absence of cervical intraepithelial neoplasia (CIN) of different degrees or invasive cervical cancer. Verification was based on colposcopy and histological interpretation of colposcopy-directed biopsies. Negative colposcopy was accepted as a truly negative outcome. VIA showed a sensitivity of 79% (95% CI 73-85%) and 83% (95% CI 77-89%), and a specificity of 85% (95% CI 81-89%) and 84% (95% CI 80-88%) for the outcomes CIN2+ or CIN3+, respectively. VILI was on average 10% more sensitive and equally specific. VIAM showed similar results as VIA. The Pap smear showed lowest sensitivity, even at the lowest cutoff of atypical squamous cells of undetermined significance (57%; 95% CI 38-76%) for CIN2+ but the specificity was rather high (93%; 95% CI 89-97%). The HC2-assay showed a sensitivity for CIN2+ of 62% (95% CI 56-68%) and a specificity of 94% (95% CI 92-95%). Substantial interstudy variation was observed in the accuracy of the visual screening methods. Accuracy of visual methods and cytology increased over time, whereas performance of HC2 was constant. Results of visual tests and colposcopy were highly correlated. This study was the largest ever done that evaluates the cross

  1. Word Frequency Analysis MOS: 17C. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    rVERLAPPING 5 OVERLAY 3 nVT’LAYS 7 nVERWATCH 6 OWN 23 P I Ph 7 P AC IN W- PACKAGES I PAr.KET I P vily 77 P AGE LQ PArFS 2 PAIN I PAI4T I PAIPNTED 1...rntJNII wnRp𔃻 COUNT? WORD2 CC ON T3 w~p n 3 rrIuNTA WCR04 2 OVERt APPINr. 2 nYPFRUATCH 2 PACING > P VErGEc-S - 2 PAIN 2 PAIR p AAPER I PITIL 2 P ARTI...CLOSING 13 GROI )ND 13 -SiRVT 13 S~TPS 13 SWITCH 12 nOIST ANCE 12 14VIGHT d 12 LOCATIOn4 12 NCTE 17 PFrIL It1 PrSTITI nN 11 AN it APPROPRIATE 11 AREA

  2. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung.

    PubMed

    Almendros, Isaac; Gutierrez, Patricia T; Closa, Daniel; Navajas, Daniel; Farre, Ramon

    2008-06-30

    The aim was to assess whether induction of ventilator-induced lung injury (VILI) in one lung triggers a concomitant inflammatory response in the normally ventilated contralateral lung. To this end, a differential ventilator was used in 6 rats. One lung was normally ventilated (3.5 ml/kg b.w.) and the contralateral lung was overstretched (15 ml/kg b.w.). Six control rats were normally ventilated (3.5 ml/kg b.w. each lung). After 3h, edema and gene expression of MIP-2 in the lung, and plasma and liver TNF-alpha were assessed. Overexpression of MIP-2 and edema were found in the overventilated lung but not in the normally ventilated contralateral lung. No detectable levels of circulating and liver TNF-alpha were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation.

  3. μ-PIV/Shadowgraphy measurements to elucidate dynamic physicochemical interactions in a multiphase model of pulmonary airway reopening

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Eiichiro

    2010-10-01

    We employ micro-particle image velocimetry (μ-PIV) and shadowgraphy to measure the ensemble-averaged fluid-phase velocity field and interfacial geometry during pulsatile bubble propagation that includes a reverse-flow phase under influence of exogenous lung surfactant (Infasurf). Disease states such as respiratory distress syndrome (RDS) are characterized by insufficient pulmonary surfactant concentrations that enhance airway occlusion and collapse. Subsequent airway reopening, driven by mechanical ventilation, may generate damaging stresses that cause ventilator-induced lung injury (VILI). It is hypothesized that reverse flow may enhance surfactant uptake and protect the lung from VILI. The microscale observations conducted in this study will provide us with a significant understanding of dynamic physicochemical interactions that can be manipulated to reduce the magnitude of this damaging mechanical stimulus during airway reopening. Bubble propagation through a liquid-occluded fused glass capillary tube is controlled by linear-motor-driven syringe pumps that provide mean and sinusoidal velocity components. A translating microscope stage mechanically subtracts the mean velocity of the bubble tip in order to hold the progressing bubble tip in the microscope field of view. To optimize the signal-to-noise ratio near the bubble tip, μ-PIV and shadow images are recorded in separate trials then combined during post-processing with help of a custom-designed micro scale marker. Non-specific binding of Infasurf proteins to the channel wall is controlled by oxidation and chemical treatment of the glass surface. The colloidal stability and dynamic/static surface properties of the Infasurf-PIV particle solution are carefully adjusted based on Langmuir trough measurements. The Finite Time Lyapunov Exponent (FTLE) is computed to provide a Lagrangian perspective for comparison with our boundary element predictions.

  4. Model-based setting of inspiratory pressure and respiratory rate in pressure-controlled ventilation.

    PubMed

    Schranz, C; Becher, T; Schädler, D; Weiler, N; Möller, K

    2014-03-01

    Mechanical ventilation carries the risk of ventilator-induced-lung-injury (VILI). To minimize the risk of VILI, ventilator settings should be adapted to the individual patient properties. Mathematical models of respiratory mechanics are able to capture the individual physiological condition and can be used to derive personalized ventilator settings. This paper presents model-based calculations of inspiration pressure (pI), inspiration and expiration time (tI, tE) in pressure-controlled ventilation (PCV) and a retrospective evaluation of its results in a group of mechanically ventilated patients. Incorporating the identified first order model of respiratory mechanics in the basic equation of alveolar ventilation yielded a nonlinear relation between ventilation parameters during PCV. Given this patient-specific relation, optimized settings in terms of minimal pI and adequate tE can be obtained. We then retrospectively analyzed data from 16 ICU patients with mixed pathologies, whose ventilation had been previously optimized by ICU physicians with the goal of minimization of inspiration pressure, and compared the algorithm's 'optimized' settings to the settings that had been chosen by the physicians. The presented algorithm visualizes the patient-specific relations between inspiration pressure and inspiration time. The algorithm's calculated results highly correlate to the physician's ventilation settings with r = 0.975 for the inspiration pressure, and r = 0.902 for the inspiration time. The nonlinear patient-specific relations of ventilation parameters become transparent and support the determination of individualized ventilator settings according to therapeutic goals. Thus, the algorithm is feasible for a variety of ventilated ICU patients and has the potential of improving lung-protective ventilation by minimizing inspiratory pressures and by helping to avoid the build-up of clinically significant intrinsic positive end-expiratory pressure.

  5. Nicotinamide Exacerbates Hypoxemia in Ventilator-Induced Lung Injury Independent of Neutrophil Infiltration

    PubMed Central

    Jones, Heather D.; Yoo, Jeena; Crother, Timothy R.; Kyme, Pierre; Ben-Shlomo, Anat; Khalafi, Ramtin; Tseng, Ching W.; Parks, William C.; Arditi, Moshe

    2015-01-01

    Background Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-induced lung injury and exacerbates the injury when given exogenously. Nicotinamide (vitamin B3) directly inhibits downstream pathways activated by Nicotinamide phosphoribosyltransferase and is protective in other models of acute lung injury. Methods We administered nicotinamide i.p. to mice undergoing mechanical ventilation with high tidal volumes to study the effects of nicotinamide on ventilator-induced lung injury. Measures of injury included oxygen saturations and bronchoalveolar lavage neutrophil counts, protein, and cytokine levels. We also measured expression of nicotinamide phosophoribosyltransferase, and its downstream effectors Sirt1 and Cebpa, Cebpb, Cebpe. We assessed the effect of nicotinamide on the production of nitric oxide during ventilator-induced lung injury. We also studied the effects of ventilator-induced lung injury in mice deficient in C/EBPε. Results Nicotinamide treatment significantly inhibited neutrophil infiltration into the lungs during ventilator-induced lung injury, but did not affect protein leakage or cytokine production. Surprisingly, mice treated with nicotinamide developed significantly worse hypoxemia during mechanical ventilation. This effect was not linked to increases in nitric oxide production or alterations in expression of Nicotinamide phosphoribosyl transferase, Sirt1, or Cebpa and Cebpb. Cebpe mRNA levels were decreased with either nicotinamide treatment or mechanical ventilation, but mice lacking C/EBPε developed the same degree of hypoxemia and ventilator-induced lung injury as wild-type mice. Conclusions Nicotinamide treatment during VILI inhibits neutrophil infiltration of the lungs consistent with a strong anti-inflammatory effect, but

  6. Influence of mechanical ventilation and sepsis on redox balance in diaphragm, myocardium, limb muscles, and lungs.

    PubMed

    Chacon-Cabrera, Alba; Rojas, Yeny; Martínez-Caro, Leticia; Vila-Ubach, Monica; Nin, Nicolas; Ferruelo, Antonio; Esteban, Andrés; Lorente, José A; Barreiro, Esther

    2014-12-01

    Mechanical ventilation (MV), using high tidal volumes (V(T)), causes lung (ventilator-induced lung injury [VILI]) and distant organ injury. Additionally, sepsis is characterized by increased oxidative stress. We tested whether MV is associated with enhanced oxidative stress in sepsis, the commonest underlying condition in clinical acute lung injury. Protein carbonylation and nitration, antioxidants, and inflammation (immunoblotting) were evaluated in diaphragm, gastrocnemius, soleus, myocardium, and lungs of nonseptic and septic (cecal ligation and puncture 24 hours before MV) rats undergoing MV (n = 7 per group) for 150 minutes using 3 different strategies (low V(T) [V(T) = 9 mL/kg], moderate V(T) [V(T) = 15 mL/kg], and high V(T) [V(T) = 25 mL/kg]) and in nonventilated control animals. Compared with nonventilated control animals, in septic and nonseptic rodents (1) diaphragms, limb muscles, and myocardium of high-V(T) rats exhibited a decrease in protein oxidation and nitration levels, (2) antioxidant levels followed a specific fiber-type distribution in slow- and fast-twitch muscles, (3) tumor necrosis factor α (TNF-α) levels were higher in respiratory and limb muscles, whereas no differences were observed in myocardium, and (4) in lungs, protein oxidation was increased, antioxidants were rather decreased, and TNF-α remained unmodified. In this model of VILI, oxidative stress does not occur in distant organs or skeletal muscles of rodents after several hours of MV with moderate-to-high V(T), whereas protein oxidation levels were increased in the lungs of the animals. Inflammatory events were moderately expressed in skeletal muscles and lungs of the MV rats. Concomitant sepsis did not strongly affect the MV-induced effects on muscles, myocardium, or lungs in the rodents.

  7. Universal cumulants of the current in diffusive systems on a ring.

    PubMed

    Appert-Rolland, C; Derrida, B; Lecomte, V; van Wijland, F

    2008-08-01

    We calculate exactly the first cumulants of the integrated current and of the activity (which is the total number of changes of configurations) of the symmetric simple exclusion process on a ring with periodic boundary conditions. Our results indicate that for large system sizes the large deviation functions of the current and of the activity take a universal scaling form, with the same scaling function for both quantities. This scaling function can be understood either by an analysis of Bethe ansatz equations or in terms of a theory based on fluctuating hydrodynamics or on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim.

  8. [Crisis in medical ethics].

    PubMed

    Stellamor, K

    1996-01-01

    There is a disproportion between diagnostic and therapeutic medical achievements and the doctor/patient relationship. Are we allowed to do everything we are able to do in medicine? People are concerned and worried (genetic technology, invasive medicine, embryos in test tubes etc.). The crisis of ethics in medicine is evident. The analysis of the situation shows one of the causes in the shift of the paradigma-modern times to postmodern following scientific positivism-but also a loss of ethics in medicine due to an extreme secularism and to modern philosophical trends (Hans Jonas and the responsibility for the future and on the other hand modern utilitarism).

  9. Production of {omega}{pi}{sup 0} pairs in electron-positron annihilation

    SciTech Connect

    Arbuzov, A. B.; Kuraev, E. A.; Volkov, M. K.

    2011-04-15

    The process of electron-positron annihilation into a pair of {pi}{sup 0} and {omega} mesons is considered in the framework of the SU(2)xSU(2) Nambu-Jona-Lasinio model. Contributions of intermediate photons, {rho}(770) and {rho}{sup '}(1450) vector mesons are taken into account. It is shown that the bulk of the cross section at energies below 2 GeV is provided by the process with intermediate {rho}{sup '}(1450) state. The contribution due to single photon and {rho}(770) exchange is in agreement with the vector meson dominance model. Numerical results are compared with experimental data.

  10. Responses of quark condensates to the chemical potential

    NASA Astrophysics Data System (ADS)

    Miyamura, O.; Choe, S.; Liu, Y.; Takaishi, T.; Nakamura, A.

    2002-10-01

    The responses of quark condensates to the chemical potential, as a function of temperature T and chemical potential μ, are calculated within the Nambu-Jona-Lasinio (NJL) model. We compare our results with those from the recent lattice QCD simulations [QCD-TARO Collaboration, S. Choe et al., Nucl. Phys. B (Proc. Suppl.) 106, 462 (2002)]. The NJL model and lattice calculations show qualitatively similar behavior, and they will be complimentary ways to study hadrons at finite density. The behavior above Tc requires more elaborated analyses.

  11. I think they're doing research on my patients, but I can't get anyone to listen.

    PubMed

    Jackson, B S; Ramsey, G C; Sidel, V W; Powderly, K E

    1998-10-01

    JONA's Management Case Studies presents provocative issues in nursing management, including personnel management, ethics, labor relations, economics, staffing, interdisciplinary relations, and career management. Experts in the field share their perspectives on the issue. Readers are encouraged to submit cases of 250 to 300 words. The case may be based on factual information but should be altered to make individuals and institutions unidentifiable. Authors of cases will not be identified although they will be offered the opportunity to be one of the expert case commentators.

  12. Disorder and Quantum Chromodynamics -- Non-Linear σ Models

    NASA Astrophysics Data System (ADS)

    Guhr, Thomas; Wilke, Thomas

    2001-10-01

    The statistical properties of Quantum Chromodynamics (QCD) show universal features which can be modeled by random matrices. This has been established in detailed analyses of data from lattice gauge calculations. Moreover, systematic deviations were found which link QCD to disordered systems in condensed matter physics. To furnish these empirical findings with analytical arguments, we apply and extend the methods developed in disordered systems to construct a non-linear σ model for the spectral correlations in QCD. Our goal is to derive connections to other low-energy effective theories, such as the Nambu-Jona-Lasinio model, and to chiral perturbation theory.

  13. Disorder and Quantum Chromodynamics - Non-Linear σ Models

    NASA Astrophysics Data System (ADS)

    Guhr, Thomas; Wilke, Thomas

    The statistical properties of Quantum Chromodynamics (QCD) show universal features which can be modeled by random matrices. This has been established in detailed analyses of data from lattice gauge calculations. Moreover, systematic deviations were found which link QCD to disordered systems in condensed matter physics. To furnish these empirical findings with analytical arguments, we apply and extend the methods developed in disordered systems to construct a non-linear σ model for the spectral correlations in QCD. Our goal is to derive connections to other low-energy effective theories, such as the Nambu-Jona-Lasinio model, and to chiral perturbation theory.

  14. On properties of low-lying spin-1 hadron resonances

    NASA Astrophysics Data System (ADS)

    Chizhov, M. V.

    2017-03-01

    Properties of low-lying spin-1 hadron resonances are described in the review. It is shown how the Nambu-Jona-Lasinio model can be extended in the chiral invariant way by new tensor interactions. New mass formulas are obtained, which are not based on unitary symmetry groups but involve particles from different multiplets even with opposite parity. They all are in good agreement with experimental data. Dynamic properties of spin-1 mesons confirmed by the calculations performed using the QCD sum rule technique and the lattice calculations are understood and explained.

  15. Magnetic catalysis and inverse magnetic catalysis in nonlocal chiral quark models

    NASA Astrophysics Data System (ADS)

    Pagura, V. P.; Gómez Dumm, D.; Noguera, S.; Scoccola, N. N.

    2017-02-01

    We study the behavior of strongly interacting matter under an external constant magnetic field in the context of nonlocal chiral quark models within the mean field approximation. We find that at zero temperature the behavior of the quark condensates shows the expected magnetic catalysis effect, our predictions being in good quantitative agreement with lattice QCD results. On the other hand, in contrast to what happens in the standard local Nambu-Jona-Lasinio model, when the analysis is extended to the case of finite temperature, our results show that nonlocal models naturally lead to the inverse magnetic catalysis effect.

  16. Effects of chiral imbalance and magnetic field on pion superfluidity and color superconductivity

    NASA Astrophysics Data System (ADS)

    Cao, Gaoqing; Zhuang, Pengfei

    2015-11-01

    The effects of chiral imbalance and external magnetic field on pion superfluidity and color superconductivity are investigated in extended Nambu-Jona-Lasinio models. We take the Schwinger approach to treat the interaction between the charged pion condensate and magnetic field at finite isospin density and include simultaneously the chiral imbalance and magnetic field at finite baryon density. For the superfluidity, the chiral imbalance and magnetic field lead to catalysis and inverse catalysis effects, respectively. For the superconductivity, the chiral imbalance enhances the critical baryon density, and the magnetic field results in a de Haas-van Alphan oscillation on the phase transition line.

  17. Human Operator Modeling for Aerial Tracking.

    DTIC Science & Technology

    1980-12-01

    HUMAN OPERATOR MODELING FOR AERIAL TRACKING JONA THAN KORN ARTER. EPHRATH DA VLD L. KLEINMAN DBCXMBt 19MDTICSELECTE APR 3 1981.j B Approwd for pVA& u...8217the "Guid 8en th Cart end Use of laboratory Animals, "Inatitate of Laboratory Animl ReaNuWAes, National Rtesarch CouncL The voluntary Infomed consent...Continue. on reverse aide If necessary and identify hc block numbrh) ._Modern Optimal Control techniques are e:iployed to investigate and model human

  18. [Moral aspects of human cloning and relations between humans].

    PubMed

    Lukow, P

    2001-01-01

    It is usually assumed that there is a strong logical relationship between traditional worldviews and attitudes towards human cloning. I argue that the association is contingent, which can be seen in the analysis of arguments of such leading bioethicists as G. J. Annas, H. Jonas, and J. A. Robertson. Traditional worldviews lack conceptual resources that would enable them to provide normative conclusions about cloning. It is therefore mistake to look to these traditional worldviews in search for moral instruction. Instead, one should appeal to knowledge of psychological and social aspects of human life, and in particular to the process of emotional ties which form relations between humans.

  19. Ice limit of Coulomb gauge Yang-Mills theory

    SciTech Connect

    Heinzl, T.; Ilderton, A.; Langfeld, K.; Lavelle, M.; McMullan, D.

    2008-10-01

    In this paper we describe gauge invariant multiquark states generalizing the path integral framework developed by Parrinello, Jona-Lasinio, and Zwanziger to amend the Faddeev-Popov approach. This allows us to produce states such that, in a limit which we call the ice limit, fermions are dressed with glue exclusively from the fundamental modular region associated with Coulomb gauge. The limit can be taken analytically without difficulties, avoiding the Gribov problem. This is illustrated by an unambiguous construction of gauge invariant mesonic states for which we simulate the static quark-antiquark potential.

  20. Transport theory with self-consistent confinement related to the lattice data

    NASA Astrophysics Data System (ADS)

    Bożek, P.; He, Y. B.; Hüfner, J.

    1998-06-01

    The space-time development of a quark-gluon plasma is calculated from a Vlasov equation for the distribution function of quasiparticles with medium dependent masses. At each space-time point the masses are calculated self-consistently from a gap equation, whose form is determined by the requirement that in thermal equilibrium and for a range of temperatures the energy density of the quasiparticle system is identical to the one from lattice calculations. The numerical solutions of the Vlasov equation display confinement. Relations to effective theories like that by Friedberg and Lee and Nambu and Jona-Lasinio are established.

  1. Universal current fluctuations in the symmetric exclusion process and other diffusive systems

    NASA Astrophysics Data System (ADS)

    Akkermans, Eric; Bodineau, Thierry; Derrida, Bernard; Shpielberg, Ohad

    2013-07-01

    Using the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim, one can show that the statistics of the current of the symmetric simple exclusion process (SSEP) connected to two reservoirs on an arbitrary large finite domain in dimension d are the same as in the one-dimensional case. Numerical results on squares support this claim while results on cubes exhibit some discrepancy. We argue that the results of the macroscopic fluctuation theory should be recovered by increasing the size of the contacts. The generalization to other diffusive systems is straightforward.

  2. Universal cumulants of the current in diffusive systems on a ring

    NASA Astrophysics Data System (ADS)

    Appert-Rolland, C.; Derrida, B.; Lecomte, V.; van Wijland, F.

    2008-08-01

    We calculate exactly the first cumulants of the integrated current and of the activity (which is the total number of changes of configurations) of the symmetric simple exclusion process on a ring with periodic boundary conditions. Our results indicate that for large system sizes the large deviation functions of the current and of the activity take a universal scaling form, with the same scaling function for both quantities. This scaling function can be understood either by an analysis of Bethe ansatz equations or in terms of a theory based on fluctuating hydrodynamics or on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim.

  3. Chiral phase transition from string theory.

    PubMed

    Parnachev, Andrei; Sahakyan, David A

    2006-09-15

    The low energy dynamics of a certain D-brane configuration in string theory is described at weak t'Hooft coupling by a nonlocal version of the Nambu-Jona-Lasinio model. We study this system at finite temperature and strong t'Hooft coupling, using the string theory dual. We show that for sufficiently low temperatures chiral symmetry is broken, while for temperatures larger then the critical value, it gets restored. We compute the latent heat and observe that the phase transition is of the first order.

  4. A transformational model for the practice of professional nursing. Part 2, Implementation of the model.

    PubMed

    Wolf, G A; Boland, S; Aukerman, M

    1994-05-01

    Our healthcare system is undergoing major transformation. Most nurse executives are convinced that change is necessary and inevitable, but they are less certain how to position their departments for future success. The Transformational Model for the Practice of Professional Nursing was developed as a "road map" for that purpose. Part 1 (JONA, April 1994) discussed the professional practice paradigm shifts that are needed for future success. The model components were presented and applications identified. Part 2 discusses the implementation of this model in a practice setting.

  5. A transformational model for the practice of professional nursing. Part 1, The model.

    PubMed

    Wolf, G A; Boland, S; Aukerman, M

    1994-04-01

    Our healthcare system is undergoing major transformation. Most nurse executives know that change is necessary and inevitable, but are less certain how to position their departments for these changes. The Transformational Model for the Practice of Professional Nursing was developed as a "road map" for that purpose. Part 1 of the model discusses the paradigm shifts that need to occur in professional practice for future success. The various components of the model are presented, and applications are identified. Part 2 will appear in the May 1994 issue of JONA, and will discuss the implementation of this model into a practice setting.

  6. Magnetic-field induced critical endpoint

    NASA Astrophysics Data System (ADS)

    Rechenberger, Stefan

    2017-03-01

    The phase diagram of strong interaction matter is analyzed utilizing the Nambu-Jona-Lasinio model. Special emphasis is placed on its dependence on an external magnetic field and isospin chemical potential. Using flavor mixing induced by instanton effects the influence of isospin breaking due to the magnetic field and the isospin chemical potential is compared. It is found that at low temperatures and large quark chemical potential the magnetic field, depending on its strength, induces a new critical endpoint or a triple point.

  7. Phase structure in a chiral model of nuclear matter

    SciTech Connect

    Phat, Tran Huu; Anh, Nguyen Tuan; Tam, Dinh Thanh

    2011-08-15

    The phase structure of symmetric nuclear matter in the extended Nambu-Jona-Lasinio (ENJL) model is studied by means of the effective potential in the one-loop approximation. It is found that chiral symmetry gets restored at high nuclear density and a typical first-order phase transition of the liquid-gas transition occurs at zero temperature, T=0, which weakens as T grows and eventually ends up with a second-order critical point at T=20 MeV. This phase transition scenario is confirmed by investigating the evolution of the effective potential versus the effective nucleon mass and the equation of state.

  8. Critical end point in the presence of a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Cui, Z.-F.; Cloët, I. C.; Lu, Y.; Roberts, C. D.; Schmidt, S. M.; Xu, S.-S.; Zong, H.-S.

    2016-10-01

    A class of Polyakov-loop-modified Nambu-Jona-Lasinio models has been used to support a conjecture that numerical simulations of lattice-regularized QCD defined with a chiral chemical potential can provide information about the existence and location of a critical end point in the QCD phase diagram drawn in the plane spanned by baryon chemical potential and temperature. That conjecture is challenged by conflicts between the model results and analyses of the same problem using simulations of lattice-regularized QCD (lQCD) and well-constrained Dyson-Schwinger equation (DSE) studies. We find the conflict is resolved in favor of the lQCD and DSE predictions when both a physically motivated regularization is employed to suppress the contribution of high-momentum quark modes in the definition of the effective potential connected with the Polyakov-loop-modified Nambu-Jona-Lasinio models and the four-fermion coupling in those models does not react strongly to changes in the mean field that is assumed to mock-up Polyakov-loop dynamics. With the lQCD and DSE predictions thus confirmed, it seems unlikely that simulations of lQCD with μ5>0 can shed any light on a critical end point in the regular QCD phase diagram.

  9. A revision of Pheidole Westwood (Hymenoptera: Formicidae) in the islands of the southwest Indian Ocean and designation of a neotype for the invasive Pheidole megacephala.

    PubMed

    Fischer, G; Fisher, B L

    2013-01-01

    The myrmicine genus Pheidole Westwood is revised for the smaller islands of the Southwest Indian Ocean: Comoros, Juan de Nova Island, Mauritius, Mayotte, Reunion, and the Seychelles. Descriptions and keys are provided for the thirteen species on these islands of which seven are newly described: P. decepticon sp. n., P. dodo sp. n., P. komori sp. n, P. loki sp. n., P. megatron sp. n., P. ragnax sp. n., P. vulcan sp. n.; and six were previously described: P. braueri Forel, P. fervens Smith, F., P. jonas Forel, P. megacephala (Fabricius), P. parva Forel, and P. teneriffana Forel. New synonymies (with the senior synonym listed first) include P. parva Mayr = P. flavens var. farquharensis Forel, P. parva Mayr = P. tarda Donisthorpe, P. megacephala (Fabricius) = P. picata Forel, P. megacephala (Fabricius) = P. punctulata r. gietleni Forel, 1905, P. megacephala (Fabricius) = P. picata var. bernhardae Emery, 1915, P. megacephala (Fabricius) = P megacephala r. scabrior Forel, and P. teneriffana Forel = P. voeltzkowii Forel. Furthermore, lectotypes are designated from the syntypes of P. braueri, P. fervens, P. jonas, P. parva, and P. teneriffana in order to provide a single name-bearing specimen and to facilitate future taxonomic studies. Finally, a neotype is provided for the untraceable or possibly lost type of the cosmopolitan and invasive P. megacephala, which was originally described by Fabricius from Mauritius (the former 'Ile de France').

  10. Possible formation of high temperature superconductor at an early stage of heavy-ion collisions

    NASA Astrophysics Data System (ADS)

    Liu, Hao; Yu, Lang; Chernodub, Maxim; Huang, Mei

    2016-12-01

    We investigate the effect of the inverse magnetic catalysis (IMC) on charged ρ meson condensation at finite temperature in the framework of the Nambu-Jona-Lasinio model, where mesons are calculated to the leading order of 1 /Nc expansion. The IMC for chiral condensate has been considered using three different approaches: incorporating the chiral condensate from lattice data, using the running coupling constant, and introducing the chiral chemical potential, respectively. It is observed that with no IMC effect included, the critical magnetic field e Bc for charged ρ condensation increases monotonically with the temperature. However, including IMC substantially affects the polarized charged ρ condensation around the critical temperature Tc of the chiral phase transition: first, the critical magnetic field e Bc for the charged ρ condensation decreases with the temperature, reaches its minimum value around Tc, and then increases with the temperature. It is quite surprising that the charged ρ can condense above the critical temperature of chiral phase transition with a even smaller critical magnetic field comparing its vacuum value. The Nambu-Jona-Lasinio model calculation shows that in the temperature region of 1 - 1.5 Tc , the critical magnetic field for charged ρ condensation is rather small and in the region of e Bc˜0.15 - 0.3 GeV2 , which suggests that high temperature superconductor might be created through noncentral heavy ion collisions at LHC energies.

  11. Quark fragmentation functions in NJL-jet model

    NASA Astrophysics Data System (ADS)

    Bentz, Wolfgang; Matevosyan, Hrayr; Thomas, Anthony

    2014-09-01

    We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. We report on our studies of quark fragmentation functions in the Nambu-Jona-Lasinio (NJL) - jet model. The results of Monte-Carlo simulations for the fragmentation functions to mesons and nucleons, as well as to pion and kaon pairs (dihadron fragmentation functions) are presented. The important role of intermediate vector meson resonances for those semi-inclusive deep inelastic production processes is emphasized. Our studies are very relevant for the extraction of transverse momentum dependent quark distribution functions from measured scattering cross sections. Supported by Grant in Aid for Scientific Research, Japanese Ministry of Education, Culture, Sports, Science and Technology, Project No. 20168769.

  12. Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats

    PubMed Central

    Loring, Stephen H.; Pecchiari, Matteo; Valle, Patrizia Della; Monaco, Ario; Gentile, Guendalina; D'Angelo, Edgardo

    2014-01-01

    Objective To see whether in acute lung injury (ALI) 1) compression of the lungs caused by thoracoabdominal constriction degrades lung function and worsens ventilator-induced lung injury (VILI), and 2) maintaining end-expiratory transpulmonary pressure (Pl) by increasing positive end-expiratory pressure (PEEP) reduces the deleterious effects of chest wall constriction. Design Experimental study in rats. Setting Physiology laboratory. Interventions ALI was induced in 3 groups of 9 rats by saline lavage. Nine animals immediately sacrificed served as control group. Group L had lavage only, group LC had the chest wall constricted with an elastic binder, and group LCP had the same chest constriction but with PEEP raised to maintain end-expiratory Pl. After lavage, all groups were ventilated with the same pattern for 1½ hr. Measurements and Main Results Pl, measured with an esophageal balloon-catheter, lung volume changes, arterial blood gasses and pH were assessed during mechanical ventilation (MV). Lung wet-to-dry ratio (W/D), albumin, TNF-α, IL-1β, IL-6, IL-10, and MIP-2 in serum and bronchoalveolar lavage fluid (BALF), and serum E-selectin and von Willebrand Factor (vWF) were measured at the end of MV. Lavage caused hypoxemia and acidemia, increased lung resistance and elastance, and decreased end-expiratory lung volume. With prolonged MV, lung mechanics, hypoxemia, and W/D were significantly worse in group LC. Pro-inflammatory cytokines except E-selectin were elevated in serum and BALF in all groups, with significantly greater levels of TNF-α, IL-1β, and IL-6 in group LC, which also exhibited significantly worse bronchiolar injury and greater heterogeneity of airspace expansion at a fixed Pl than other groups. Conclusions Chest wall constriction in ALI reduces lung volume, worsens hypoxemia, and increases pulmonary edema, mechanical abnormalities, pro-inflammatory mediator release, and histological signs of VILI. Maintaining end-expiratory Pl at preconstriction

  13. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

    PubMed Central

    2011-01-01

    Background A new lower-cost rapid-throughput human papillomavirus (HPV) test (careHPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia. Methods We assessed the outcomes and cost-effectiveness of careHPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed. Results For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; careHPV@1.0 pg/ml and careHPV@0.5 pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for careHPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for careHPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using careHPV@1.0) per LYS. Conclusions This modelled analysis suggests that primary careHPV screening compares

  14. Trials and projects on cervical cancer and human papillomavirus prevention in sub-Saharan Africa.

    PubMed

    Adefuye, Peter O; Broutet, Nathalie J; de Sanjosé, Silvia; Denny, Lynette A

    2013-12-29

    Cervical cancer is the leading cause of cancer morbidity and mortality in women in sub-Saharan Africa (SSA), accounting for about 50,000 deaths annually. Until recently, cytology was the gold standard for screening and prevention of cervical cancer. This method of screening has not been successful in SSA due to a lack of human, financial and material resources and poor health care infrastructure. It is estimated that less than 5% of at risk women have ever being screened. In the past two decades alternative approaches to cytology for cervical cancer screening have been evaluated in low- and medium-income countries. Visual inspection with acetic acid (VIA) and/or Lugol's iodine (VILI) have been shown to have adequate sensitivity, although low specificity, in a number of cross-sectional research and demonstration projects. Visual inspection methods require minimal resources, are technologically accessible, and are feasible for screening for precancerous lesions. Linking screening with VIA/VILI to treatment with cryotherapy may enable screening and treatment to take place in one visit, but this is likely to result in large numbers of women being subjected to unnecessary treatment. A number of studies have shown that cryotherapy is not associated with significant side effects or complications and is well tolerated. Creating the infrastructure for screening of older women is considered desirable, despite the limitations of visual inspection methods as screening tests. Understanding the role of human papillomavirus (HPV) infection in the etiology of cervical cancer and the discovery of HPV rapid test kits, as well as the development of vaccines against the HPV oncogenic types, have created new opportunities for prevention of cervical cancer. Trials and projects have established (and are still ongoing) the feasibility of using these molecular tests for screening. The ultimate in prevention method is primary prevention, offered by the advent of prophylactic vaccines

  15. Burden of cervical cancer and role of screening in India

    PubMed Central

    Bobdey, Saurabh; Sathwara, Jignasa; Jain, Aanchal; Balasubramaniam, Ganesh

    2016-01-01

    Background: Cervical cancer is a major cause of cancer mortality in women and more than a quarter of its global burden is contributed by developing countries. In India, in spite of alarmingly high figures, there is no nationwide government-sponsored screening program. This study was conducted to assess the burden of cervical cancer in India and review the performance characteristics of available cervical cancer screening tools, so as to provide evidence-based recommendations for application of most practically suited screening test to be used in resource-poor field settings. Materials and Methods: MEDLINE and Web of Science electronic database were searched from January 1990 to December 2015, using the keywords such as “cervical cancer”, “screening”, “early detection”, “cervical cytology” and “visual inspection”, and their corresponding MeSH terms in combination with Boolean operators “OR, AND.” Two authors independently selected studies that are published in English and conducted in India. A total of 11 studies were found to be relevant and eligible to be included in the present study. Results: In India, cervical cancer contributes to approximately 6–29% of all cancers in women. The age-adjusted incidence rate of cervical cancer varies widely among registries; highest is 23.07/100,000 in Mizoram state and the lowest is 4.91/100,000 in Dibrugarh district. The pooled estimates of sensitivity and specificity of visual inspection with acetic acid (VIA), magnified VIA, visual inspection with Lugol's iodine (VILI), cytology (Pap smear), and human papillomavirus DNA were found to be 67.65% and 84.32%, 65.36% and 85.76%, 78.27% and 87.10%, 62.11% and 93.51%, and 77.81% and 91.54%, respectively. Conclusions: In developing countries because of lack of necessary infrastructure and quality control, high-quality cytology screening may not be feasible for wide-scale implementation. Hence, cervical cancer screening program based on visual screening test

  16. Modern compact star observations and the quark matter equation of state

    NASA Astrophysics Data System (ADS)

    Klähn, T.; Blaschke, D.; Sandin, F.; Fuchs, Ch.; Faessler, A.; Grigorian, H.; Röpke, G.; Trümper, J.

    2007-10-01

    We present a hybrid equation of state (EoS) for dense matter that satisfies phenomenological constraints from modern compact star (CS) observations which indicate high maximum masses (M ∼ 2M⊙) and large radii (R > 12 km). The corresponding isospin symmetric EoS is consistent with flow data analyses of heavy-ion collisions and a deconfinement transition at ∼ 0.55 fm-3. The quark matter phase is described by a 3-flavor Nambu-Jona-Lasinio model that accounts for scalar diquark condensation and vector meson interactions while the nuclear matter phase is obtained within the Dirac-Brueckner-Hartree-Fock (DBHF) approach using the Bonn-A potential. We demonstrate that both pure neutron stars and neutron stars with quark matter cores are consistent with modern CS observations. Hybrid star configurations with a CFL quark core are unstable within the present model.

  17. Low-energy phenomenology of scalarless standard-model extensions with high-energy Lorentz violation

    SciTech Connect

    Anselmi, Damiano; Ciuffoli, Emilio

    2011-03-01

    We consider renormalizable standard model extensions that violate Lorentz symmetry at high energies, but preserve CPT, and do not contain elementary scalar fields. A Nambu-Jona-Lasinio mechanism gives masses to fermions and gauge bosons and generates composite Higgs fields at low energies. We study the effective potential at the leading order of the large-N{sub c} expansion, prove that there exists a broken phase, and study the phase space. In general, the minimum may break invariance under boosts, rotations, and CPT, but we give evidence that there exists a Lorentz invariant phase. We study the spectrum of composite bosons and the low-energy theory in the Lorentz phase. Our approach predicts relations among the parameters of the low-energy theory. We find that such relations are compatible with the experimental data within theoretical errors. We also study the mixing among generations, the emergence of the CKM matrix, and neutrino oscillations.

  18. Quark mass functions and pion structure in Minkowski space

    SciTech Connect

    Biernat, Elmer P.; Gross, Franz L.; Pena, Maria Teresa; Stadler, Alfred

    2014-03-01

    We present a study of the dressed quark mass function and the pion structure in Minkowski space using the Covariant Spectator Theory (CST). The quark propagators are dressed with the same kernel that describes the interaction between different quarks. We use an interaction kernel in momentum space that is a relativistic generalization of the linear confining q-qbar potential and a constant potential shift that defines the energy scale. The confining interaction has a Lorentz scalar part that is not chirally invariant by itself but decouples from the equations in the chiral limit and therefore allows the Nambu--Jona-Lasinio (NJL) mechanism to work. We adjust the parameters of our quark mass function calculated in Minkowski-space to agree with LQCD data obtained in Euclidean space. Results of a calculation of the pion electromagnetic form factor in the relativistic impulse approximation using the same mass function are presented and compared with experimental data.

  19. Studies of the hybrid star structure within 2 +1 flavors NJL model

    NASA Astrophysics Data System (ADS)

    Li, Cheng-Ming; Zhang, Jin-Li; Zhao, Tong; Zhao, Ya-Peng; Zong, Hong-Shi

    2017-03-01

    In this paper, we use the equation of state (EOS) of the 2 +1 flavors Nambu-Jona-Lasinio (NJL) model to study the structure of compact stars. To avoid the ultraviolet divergence, we employ the proper-time regularization (PTR) with an ultraviolet cutoff. For comparison, we fix three sets of parameters, where the constraints of chemical equilibrium and electric charge neutrality conditions are taken into consideration. With a certain interpolation method in the crossover region, we construct three corresponding hybrid EOSs but find that the maximum masses of hybrid stars in the three different cases do not differ too much. It should be pointed out that the results we get are in accordance with the recent astro-observation PSR J 0348 +0432 , PSR J 1614 -2230 , PSR J 1946 +3417 .

  20. {eta}'(958)-mesic nuclei formation and UA(1) anomaly at finite density

    SciTech Connect

    Nagahiro, Hideko; Takizawa, Makoto; Hirenzaki, Satoru

    2006-07-11

    We discuss the possibility of producing the bound states of the {eta}'(958) meson in nuclei theoretically using the the Nambu-Jona-Lasinio (NJL) model. We calculate the formation cross section of the {eta}' bound states with the Green function method for the ({gamma},p) reaction and discuss the experimental feasibility at photon facilities such as SPring-8. We conclude that we can expect to observe resonance peaks in ({gamma},p) spectra for the formation of {eta}' bound states and we can deduce new information on {eta}' properties at finite density. These observations are believed to be essential to know the possible mass shift of {eta}' and deduce new information on the effective restoration of the chiral UA(1) anomaly at finite density.

  1. Critical temperature of chiral symmetry restoration for quark matter with a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.

    2016-12-01

    In this article we study the restoration of chiral symmetry at a finite temperature for quark matter with a chiral chemical potential, {μ }5, by means of a nonlocal Nambu-Jona-Lasinio model. This model allows the introduction of, in the simplest way possible, a Euclidean momentum, p E , dependent quark mass function which decays (neglecting logarithms) as 1/{p}{E}2 for large p E , in agreement with the asymptotic behaviour expected in quantum chromodynamics in the presence of a nonperturbative quark condensate. We focus on the critical temperature for chiral symmetry restoration in the chiral limit, T c, versus {μ }5, as well as on the order of the phase transition. We find that T c increases with {μ }5, and that the transition remains of the second order for the whole range of {μ }5 considered.

  2. Neutrino emissivities and bulk viscosity in neutral two-flavor quark matter

    NASA Astrophysics Data System (ADS)

    Berdermann, J.; Blaschke, D.; Fischer, T.; Kachanovich, A.

    2016-12-01

    We study thermodynamic and transport properties for the isotropic color-spin-locking (iso-CSL) phase of two-flavor superconducting quark matter under compact star constraints within a Nambu-Jona-Lasinio-type chiral quark model. Chiral symmetry breaking and the phase transition to superconducting quark matter leads to a density dependent change of quark masses, chemical potentials, and diquark gap. A self-consistent treatment of these physical quantities influences the microscopic calculations of transport properties. We present results for the iso-CSL direct URCA emissivities and bulk viscosities, which fulfil the constraints on quark matter derived from cooling and rotational evolution of compact stars. We compare our results with the phenomenologically successful, but yet heuristic 2 SC +X phase. We show that the microscopically founded iso-CSL phase can replace the purely phenomenological 2 SC +X phase in modern simulations of the cooling evolution for compact stars with color-superconducting quark matter interior.

  3. Diquarks in the color-flavor locked phase of dense quark matter

    SciTech Connect

    Ebert, D.; Klimenko, K. G.

    2007-02-15

    Diquark excitations of dense quark matter are considered in the framework of the Nambu-Jona-Lasinio model with three types of massless quarks in the presence of a quark number chemical potential {mu}. We investigate the effective action of meson and diquark fields at sufficiently high values of {mu}, where the color-flavor locked (CFL) phase is realized, and prove the existence of NG bosons in the sector of pseudoscalar diquarks. In the sector of scalar diquarks an additional NG boson is found, corresponding to the spontaneous breaking of the U(1){sub B} baryon symmetry in the CFL phase. Finally, the existence of massive scalar and pseudoscalar diquark excitations is demonstrated.

  4. Stability of color-flavor-locking cores in hybrid stars

    SciTech Connect

    Pagliara, G.; Schaffner-Bielich, J.

    2008-03-15

    We study the equation of state strongly interacting quark matter within a Nambu-Jona-Lasinio-like model in which the chiral condensates and the color superconducting gaps are computed self-consistently as a function of the baryon density. A vector interaction term is added to the Lagrangian in order to render the quark matter equation of state stiffer. For the low density hadronic phase we use a relativistic mean field model. The phase transition to quark matter is computed by a Maxwell construction. We show that stable color-flavor-locking (CFL) cores in hybrid stars are possible if the superconducting gap is sufficiently large. Moreover we find stable stellar configurations in which two phase transitions occur, a first transition from hadronic matter to 2SC quark matter and a second transition from 2SC quark matter to CFL quark matter.

  5. Critical behaviors near the (tri-)critical end point of QCD within the NJL model

    NASA Astrophysics Data System (ADS)

    Lu, Ya; Du, Yi-Lun; Cui, Zhu-Fang; Zong, Hong-Shi

    2015-10-01

    We investigate the dynamical chiral symmetry breaking and its restoration at finite density and temperature within the two-flavor Nambu-Jona-Lasinio model, and mainly focus on the critical behaviors near the critical end point (CEP) and tricritical point (TCP) of quantum chromodynamics. The multi-solution region of the Nambu and Wigner ones is determined in the phase diagram for the massive and massless current quark, respectively. We use the various susceptibilities to locate the CEP/TCP and then extract the critical exponents near them. Our calculations reveal that the various susceptibilities share the same critical behaviors for the physical current quark mass, while they show different features in the chiral limit.

  6. Johann von Lamont: A Pioneer in Geomagnetism

    NASA Astrophysics Data System (ADS)

    Soffel, Heinrich

    2006-06-01

    The 200th birthday of John Lamont (1805-1879, Figure 1), a pioneer in the study of geomagnetism, was marked on 13 December 2005. Lamont founded the Munich Geomagnetic Observatory in 1840 and was a member of the group of scientists including Carl Friedrich Gauss, Alexander von Humboldt, Eduard Sabine, Jonas Angstrøm, Humphret Lloyd, Adolf Kupffer, Karl Kreil, and Adolphe Quetelet who composed the Göttingen Magnetic Union. They organized an international network of geomagnetic observatories [Barraclough et al., 1992]. The present knowledge of the geomagnetic field and its secular variation is largely based on the data collected by the global network of geomagnetic observatories during the last 170 years. Lamont's talents and his dedication and enthusiasm for discovery are reflected in the depth and scope of his contributions to a broad variety of natural sciences such as astronomy, meteorology, geomagnetism, and geodesy. However, this article just touches on his merits in geomagnetism.

  7. EMC and polarized EMC effects in Nuclei

    SciTech Connect

    Ian Cloet; Wolfgang Bentz; Anthony Thomas

    2006-05-23

    We determine nuclear structure functions and quark distributions for {sup 7}Li, {sup 11}B, {sup 15}N and {sup 27}Al. For the nucleon bound state we solve the covariant quark-diquark equations in a confining Nambu--Jona-Lasinio model, which yields excellent results for the free nucleon structure functions. The nucleus is described using a relativistic shell model, including mean scalar and vector fields that couple to the quarks in the nucleon. The nuclear structure functions are then obtained as a convolution of the structure function of the bound nucleon with the light-cone nucleon distributions. We find that we are readily able to reproduce the EMC effect in finite nuclei and confirm earlier nuclear matter studies that found a large polarized EMC effect.

  8. QCD Phase Diagram at Finite Baryon and Isospin Chemical Potentials

    SciTech Connect

    Sasaki, T.; Sakai, Y.; Yahiro, M.; Kouno, H.

    2011-10-21

    The phase structure of two-flavor QCD is explored for finite temperature T and finite baryon- and isospin-chemical potentials, {mu}{sub B} and {mu}{sub I}, by using the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. The PNJL model with the scalar-type eight-quark interaction can reproduce lattice QCD data in the {mu}{sub I}-T plane at {mu}{sub B} = 0. In the {mu}{sub I}-{mu}{sub B}-T space, the critical endpoint of the chiral phase transition in the {mu}{sub B}-T plane at {mu}{sub I} = 0 moves to the tricritical point of the pion-superfluidity phase transition in the {mu}{sub I}-T plane at {mu}{sub B} = 0 as {mu}{sub I} increases.

  9. Chiral relaxation time at the crossover of quantum chromodynamics

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.; Chernodub, M.

    2016-09-01

    We study microscopic processes responsible for chirality flips in the thermal bath of quantum chromodynamics at finite temperature and zero baryon chemical potential. We focus on the temperature range where the crossover from chirally broken phase to quark-gluon plasma takes place, namely, T ≃(150 ,200 ) MeV . The processes we consider are quark-quark scatterings mediated by collective excitations with the quantum number of pions and σ meson; hence we refer to these processes simply as one-pion (one-σ ) exchanges. We use a Nambu-Jona-Lasinio model to compute equilibrium properties of the thermal bath, as well as the relevant scattering kernel to be used in the collision integral to estimate the chiral relaxation time τ . We find τ ≃0.1 ÷1 fm /c around the chiral crossover.

  10. Validity of anomalous diffraction approximation in m- χ domain

    NASA Astrophysics Data System (ADS)

    Liu, Chun-Lei

    In a recent paper, Liu et al. [Liu, C., Jonas, P.R., Saunders, C.P.R., 1996. Accuracy of the anomalous diffraction approximation to the light scattering by column-like ice crystals. Atmos. Res. 41, 63-69] reported that the anomalous diffraction approximation (ADA) accuracy is not sensitive to van de Hulst's condition | m-1|≪1, but is dependent on the size parameter χ. Videen and Chýlek [Videen, G., Chýlek, P., 1998. Anomalous diffraction approximation limits. Atmos. Res., this issue] pointed out that this result is at odds with previous research, and their results indicated that the accuracy of ADA is much dependent on the condition of | m-1|≪1. Some calculated results are presented here to provide further discussion of the ADA validity in the calculation of particle extinction and absorption efficiencies.

  11. Spinodal instabilities in baryon-rich quark matter

    NASA Astrophysics Data System (ADS)

    Ko, Che Ming; Li, Feng

    For quark matter at finite baryon chemical potential, its density develops large fluctuations when it undergoes a first-order phase transition. Based on the Nambu-Jona-Lasinio (NJL) model, we have used the linear response theory to study the growth rate of density fluctuations and its dependence on the wavelength of unstable modes. Using the transport equation derived from the NJL model, we have also studied the time evolution of the unstable modes and the density fluctuations in a baryon-rich quark matter that is confined in a finite volume. Allowing the expansion of the quark matter, we have further studied the survivability of the density fluctuations as the density and temperature of the quark matter decrease. Possible experimental signatures of the density fluctuations have been suggested.

  12. Light-by-Light Hadronic Corrections to the Muon G-2 Problem Within the Nonlocal Chiral Quark Model

    NASA Astrophysics Data System (ADS)

    Dorokhov, A. E.; Radzhabov, A. E.; Zhevlakov, A. S.

    2017-03-01

    Results of calculation of the light-by-light contribution from the lightest neutral pseudoscalar and scalar mesons and the dynamical quark loop to the muon anomalous magnetic moment are discussed in the framework of the nonlocal SU(3) × SU(3) chiral quark model. The model is based on four-quark interaction of the Nambu-Jona-Lasinio type and Kobayashi-Maskawa-`t Hooft six-quark interaction. The full kinematic dependence of vertices with off-shell mesons and photons in intermediate states in the light-by-light scattering amplitude is taken into account. All calculations are elaborated in explicitly gauge-invariant manner. These results complete calculations of all hadronic light-by-light scattering contributions to aμ in the leading order in the 1/Nc expansion. The final result does not allow the discrepancy between the experiment and the Standard Model to be explained.

  13. Spin polarization in high density quark matter under a strong external magnetic field

    NASA Astrophysics Data System (ADS)

    Tsue, Yasuhiko; da Providência, João; Providência, Constança; Yamamura, Masatoshi; Bohr, Henrik

    In high density quark matter under a strong external magnetic field, possible phases are investigated by using the two-flavor Nambu-Jona-Lasinio (NJL) model with tensor-type four-point interaction between quarks, as well as the axial-vector-type four-point interaction. In the tensor-type interaction under the strong external magnetic field, it is shown that a quark spin polarized phase is realized in all regions of the quark chemical potential under consideration within the lowest Landau level approximation. In the axial-vector-type interaction, it is also shown that the quark spin polarized phase appears in the wide range of the quark chemical potential. In both the interactions, the quark mass in zero and small chemical potential regions increases which indicates that the chiral symmetry breaking is enhanced, namely the magnetic catalysis occurs.

  14. Equation of State of the Strong Interaction Matter in an External Magnetic Field

    NASA Astrophysics Data System (ADS)

    Zhang, Rui; Liu, Yu-Xin

    2015-10-01

    We investigate the equation of state of the strong interaction matter in a background magnetic field via the two flavor Nambu-Jona-Lasinio model. Starting from the mean-field thermodynamical potential density Ω, we calculate the pressure density p, the entropy density s, the energy density ɛ, and the interaction measure (ɛ - 3p)/T4 of the strong interaction matter at finite temperature and finite magnetic field. The results manifest that the chiral phase transition is just a crossover but not a low order phase transition. Moreover there may exist magnetic catalysis effect, and its mechanism is just the effective dimension reduction induced by the magnetic field. Supported by the National Natural Science Foundation of China under Grant Nos. 10935001, 11175004 and 11435001, and the National Key Basic Research Program of China under Grant Nos. G2013CB834400 and 2015CB856900

  15. QCD phase diagram with a chiral chemical potential

    NASA Astrophysics Data System (ADS)

    Lu, Ya; Cui, Zhu-Fang; Pan, Zan; Chang, Chao-Hsi; Zong, Hong-Shi

    2016-04-01

    The effect of chirality imbalance on the QCD phase diagram is studied within the two flavors Nambu-Jona-Lasinio model. We focus especially on the issues related to how the chiral chemical potential (μ5 ) affects the phase diagram, and find the "chiral catalysis" as well as "inverse chiral catalysis" effects, which are analogous to the magnetic catalysis and inverse magnetic catalysis effects. Furthermore, our results are different from the existing chiral model calculations, namely, there is no CEP5 on the T -μ5 plane, since the whole phase transition is a crossover. In addition, with the introduction of the chiral chemical potential, various QCD susceptibilities and the corresponding critical exponents are also studied.

  16. Vector meson condensation in a pion superfluid

    NASA Astrophysics Data System (ADS)

    Brauner, Tomáš; Huang, Xu-Guang

    2016-11-01

    We revisit the suggestion that charged ρ -mesons undergo Bose-Einstein condensation in isospin-rich nuclear matter. Using a simple version of the Nambu-Jona-Lasinio (NJL) model, we conclude that ρ -meson condensation is either avoided or postponed to isospin chemical potentials much higher than the ρ -meson mass as a consequence of the repulsive interaction with the preformed pion condensate. In order to support our numerical results, we work out a linear sigma model for pions and ρ -mesons, showing that the two models lead to similar patterns of medium dependence of meson masses. As a byproduct, we analyze in detail the mapping between the NJL model and the linear sigma model, focusing on conditions that must be satisfied for a quantitative agreement between the models.

  17. The impact of cognitive strategy instruction on deaf learners: an international comparative study.

    PubMed

    Martin, D S; Craft, A; Sheng, Z N

    2001-10-01

    Teacher cohorts in England and China received special training in techniques for teaching higher-level critical and creative cognitive strategies to deaf learners. Both cohorts implemented the strategies in the classroom at least twice weekly for 6 months. Measures included Raven's Standard Progressive Matrices (1959), a systematic observation checklist for cognitive behaviors (Martin & Craft, 1998), and critical and creative problem situations to which students had to respond. Results were compared with those from a study of similar learners in the United States (Martin & Jonas, 1985), and little difference was found. Students in all three countries improved in reasoning, devising real-world problem solutions involving critical thinking (but not creative thinking), using cognitive vocabulary in the classroom, and expressing others' viewpoints. Postintervention focus groups showed teachers in China used a more invariant sequence in teaching the cognitive strategies, but teachers in all three countries experienced similar expansion in cognitive terminology and self-perceptions as teachers of problem solving.

  18. Decision-making styles: managerial application of the MBTI and type theory.

    PubMed

    Freund, C M

    1988-12-01

    Applying type theory is a relatively inexpensive way for managers to increase effectiveness by emphasizing the qualitative issues in organizations. The author describes managerial and organizational uses of C.G. Jung's theory of psychological type, as operationalized in the Myers-Briggs Type Indicator (MBTI). The MBTI is useful not only in identifying individual preferences, but also in developing effective managerial and working terms. Knowledge of one's own type and the type of others can help managers motivate others, maximize human resources, persuade others, and gain cooperation. An article in the January 1989 issue of JONA discusses the author's use of the MBTI to assess decision-making styles and the compatibility of hospital chief nursing officers and executive officers.

  19. Fate of pion condensation in quark matter: From the chiral limit to the physical pion mass

    SciTech Connect

    Abuki, H.; Anglani, R.; Pellicoro, M.; Ruggieri, M.; Gatto, R.

    2009-02-01

    We study aspects of the pion condensation in two-flavor neutral quark matter using the Nambu-Jona-Lasinio model of QCD at finite density. We investigate the role of electric charge neutrality, and explicit symmetry breaking via quark mass, both of which control the onset of the charged pion ({pi}{sup c}) condensation. We show that the equality between the electric chemical potential and the in-medium pion mass, {mu}{sub e}=M{sub {pi}{sup -}}, as a threshold, persists even for a composite pion system in the medium, provided the transition to the pion condensed phase is of the second order. Moreover, we find that the pion condensate in neutral quark matter is extremely fragile with respect to the symmetry breaking effect via a current quark mass m, and is ruled out for m larger than the order of 10 keV.

  20. Consistent regularization and renormalization in models with inhomogeneous phases

    NASA Astrophysics Data System (ADS)

    Adhikari, Prabal; Andersen, Jens O.

    2017-02-01

    In many models in condensed matter and high-energy physics, one finds inhomogeneous phases at high density and low temperature. These phases are characterized by a spatially dependent condensate or order parameter. A proper calculation requires that one takes the vacuum fluctuations of the model into account. These fluctuations are ultraviolet divergent and must be regularized. We discuss different ways of consistently regularizing and renormalizing quantum fluctuations, focusing on momentum cutoff, symmetric energy cutoff, and dimensional regularization. We apply these techniques calculating the vacuum energy in the Nambu-Jona-Lasinio model in 1 +1 dimensions in the large-Nc limit and in the 3 +1 dimensional quark-meson model in the mean-field approximation both for a one-dimensional chiral-density wave.

  1. Microscopic versus macroscopic approaches to non-equilibrium systems

    NASA Astrophysics Data System (ADS)

    Derrida, Bernard

    2011-01-01

    The one-dimensional symmetric simple exclusion process (SSEP) is one of the very few exactly soluble models of non-equilibrium statistical physics. It describes a system of particles which diffuse with hard core repulsion on a one-dimensional lattice in contact with two reservoirs of particles at unequal densities. The goal of this paper is to review the two main approaches which lead to the exact expression of the large deviation functional of the density of the SSEP in its steady state: a microscopic approach (based on the matrix product ansatz and an additivity property) and a macroscopic approach (based on the macroscopic fluctuation theory of Bertini, De Sole, Gabrielli, Jona-Lasinio and Landim).

  2. Ab initio calculation of a global potential, vibrational energies, and wave functions for HCN/HNC, and a simulation of the (A-tilde)-(X-tilde) emission spectrum

    NASA Technical Reports Server (NTRS)

    Bowman, Joel M.; Gazdy, Bela; Bentley, Joseph A.; Lee, Timothy J.; Dateo, Christopher E.

    1993-01-01

    A potential energy surface for the HCN/HNC system which is a fit to extensive, high-quality ab initio, coupled-cluster calculations is presented. All HCN and HNC states with energies below the energy of the first delocalized state are reported and characterized. Vibrational transition energies are compared with all available experimental data on HCN and HNC, including high CH-overtone states up to 23,063/cm. A simulation of the (A-tilde)-(X-tilde) stimulated emission pumping (SEP) spectrum is also reported, and the results are compared to experiment. Franck-Condon factors are reported for odd bending states of HCN, with one quantum of vibrational angular momentum, in order to compare with the recent assignment by Jonas et al. (1992), on the basis of axis-switching arguments of a number of previously unassigned states in the SEP spectrum.

  3. Betti numbers of graded modules and cohomology of vector bundles

    NASA Astrophysics Data System (ADS)

    Eisenbud, David; Schreyer, Frank-Olaf

    2009-07-01

    In the remarkable paper Graded Betti numbers of Cohen-Macaulay modules and the multiplicity conjecture, Mats Boij and Jonas Soederberg conjectured that the Betti table of a Cohen-Macaulay module over a polynomial ring is a positive linear combination of Betti tables of modules with pure resolutions. We prove a strengthened form of their conjectures. Applications include a proof of the Multiplicity Conjecture of Huneke and Srinivasan and a proof of the convexity of a fan naturally associated to the Young lattice. With the same tools we show that the cohomology table of any vector bundle on projective space is a positive rational linear combination of the cohomology tables of what we call supernatural vector bundles. Using this result we give new bounds on the slope of a vector bundle in terms of its cohomology.

  4. π0 pole mass calculation in a strong magnetic field and lattice constraints

    NASA Astrophysics Data System (ADS)

    Avancini, Sidney S.; Farias, Ricardo L. S.; Benghi Pinto, Marcus; Tavares, William R.; Timóteo, Varese S.

    2017-04-01

    The π0 neutral meson pole mass is calculated in a strongly magnetized medium using the SU(2) Nambu-Jona-Lasinio model within the random phase approximation (RPA) at zero temperature and zero baryonic density. We employ a magnetic field dependent coupling, G (eB), fitted to reproduce lattice QCD results for the quark condensates. Divergent quantities are handled with a magnetic field independent regularization scheme in order to avoid unphysical oscillations. A comparison between the running and the fixed couplings reveals that the former produces results much closer to the predictions from recent lattice calculations. In particular, we find that the π0 meson mass systematically decreases when the magnetic field increases while the scalar mass remains almost constant. We also investigate how the magnetic background influences other mesonic properties such as fπ0 and gπ0qq.

  5. Current status of poliovirus infections.

    PubMed Central

    Melnick, J L

    1996-01-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus. PMID:8809461

  6. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography.

    PubMed

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion.

  7. [Ventilator-associated pneumonia and other infections].

    PubMed

    Bobik, Piotr; Siemiątkowski, Andrzej

    2014-01-01

    One of the fundamental elements of therapy in patients hospitalised in the Intensive Care Unit (ICU) is mechanical ventilation (MV). MV enables sufficient gas exchange in patients with severe respiratory insufficiency, thus preserving the proper functioning of organs and systems. However, clinical and experimental studies show that mechanical ventilation may cause severe complications, e.g. lung injury (VALI, VILI), systemic inflammatory response syndrome (SIRS), and, on rare occasions, multiple organ failure (MOF). Mechanical ventilation and especially endotracheal intubation are associated also with higher risk of infectious complications of the respiratory system: ventilator-associated respiratory infection (VARI) and ventilator-associated pneumonia (VAP). The complications of the MV listed above have a significant influence on the length of treatment and also on the increase of the costs of therapy and mortality of patients who stay in an ICU. These negative effects of supported breathing are the reasons for intensive research to find new biological markers of inflammation and lung injury, more sensitive and specific diagnostic instruments, more effective methods of therapy, and programs of prevention. The purpose of this article is the presentation of current knowledge concerning VAP-related infections, to allow pulmonologists and general practitioners to become more familiar with the problem. Basic and the most important data concerning the definition, epidemiology, pathophysiology, microbiology, diagnostics, treatment, and prevention of VAP have been included. Additionally, ventilator-associated tracheobronchitis (VAT) was discussed.

  8. Lung-protective ventilation in neonatology.

    PubMed

    van Kaam, Anton

    2011-01-01

    Ventilator-induced lung injury (VILI) is considered an important risk factor in the development of bronchopulmonary dysplasia (BPD) and is primarily caused by overdistension (volutrauma) and repetitive opening and collapse (atelectrauma) of terminal lung units. Lung-protective ventilation should therefore aim to reduce tidal volumes, and recruit and stabilize atelectatic lung units (open lung ventilation strategy). This review will summarize the available evidence on lung-protective ventilation in neonatology, discussing both high-frequency ventilation (HFV) and positive pressure ventilation (PPV). It shows that HFV does not appear to have a clear benefit over PPV, although most studies failed to apply a true open lung ventilation strategy during HFV. The evidence on the optimal tidal volume, positive end-expiratory pressure and the role for lung recruitment during lung-protective PPV is extremely limited. Volume-targeted ventilation seems to be a promising mode in terms of lung protection, but more studies are needed. Due to the lack of convincing evidence, lung-protective ventilation and modes seem to be implemented in daily clinical practice at a slow pace.

  9. Twin pregnancy and partial hydatidiform mole following in vitro fertilization and embryos transfer: a novel case of placental mosaicism.

    PubMed

    Sun, Cheng-juan; Zhao, You-ping; Yu, Song; Fan, Ling; Wu, Qing-qing; Li, Guang-hui; Zhang, Wei-yuan

    2012-12-01

    Twin pregnancy with mosaic partial hydatidiform mole (PHM) and survival of two healthy fetuses following in vitro fertilization and embryos transfer (IVF-ET) is a rare situation and is considered a challenge for management. A 32-year-old Chinese woman conceived twin pregnancy following IVF-ET. At 22 weeks' gestation, an additional intrauterine echogenic mass with features of PHM were shown by successive ultrasound examinations. At 35 weeks' gestation, two live male infants and two placentas were delivered by caesarean section (CS). Histologic examination of the abnormal placenta confirmed mosaic PHM. Genetic study showed the abnormal placental mosaicism (expressed in molar-69XXY and normal vili-46XY), co-existing with a hypospadia new-born (46XY) in one amniotic sac. However, the other one was normal. Serial serum β-hCG levels showed a declining trend and serum β-human chorionic gonadotropin (hCG) were undetectable at 6 months after delivery. The case demonstrated that it is possible to prolonged gestation by PHM under close surveillance during the entire pregnancy.

  10. Transpulmonary pressure monitoring during mechanical ventilation: a bench-to-bedside review.

    PubMed

    Mietto, Cristina; Malbrain, Manu L N G; Chiumello, Davide

    2015-01-01

    Different ventilation strategies have been suggested in the past in patients with acute respiratory distress syndrome (ARDS). Airway pressure monitoring alone is inadequate to assure optimal ventilatory support in ARDS patients. The assessment of transpulmonary pressure (PTP) can help clinicians to tailor mechanical ventilation to the individual patient needs. Transpulmonary pressure monitoring, defined as airway pressure (Paw) minus intrathoracic pressure (ITP), provides essential information about chest wall mechanics and its effects on the respiratory system and lung mechanics. The positioning of an esophageal catheter is required to measure the esophageal pressure (Peso), which is clinically used as a surrogate for ITP or pleural pressure (Ppl), and calculates the transpulmonary pressure. The benefits of such a ventilation approach are avoiding excessive lung stress and individualizing the positive end-expiratory pressure (PEEP) setting. The aim is to prevent over-distention of alveoli and the cyclic recruitment/derecruitment or shear stress of lung parenchyma, mechanisms associated with ventilator-induced lung injury (VILI). Knowledge of the real lung distending pressure, i.e. the transpulmonary pressure, has shown to be useful in both controlled and assisted mechanical ventilation. In the latter ventilator modes, Peso measurement allows one to assess a patient's respiratory effort, patient-ventilator asynchrony, intrinsic PEEP and the calculation of work of breathing. Conditions that have an impact on Peso, such as abdominal hypertension, will also be discussed briefly.

  11. Musculo-nasomucosal unit with complete lateral bony freeing and medial rotation for ideal C-shape restoration and retropositioning of the levator veli palatini.

    PubMed

    El-Shazly, Mohamed

    2012-11-01

    No definitive procedure for cleft repair has been identified yet as the gold standard. Accordingly, this work tried to appraise the hypothesis that if the bony detachment and full retropositioning of the levator veli palatini muscle can ideally present an anatomical C-shape muscular sling restoration and if this is accompanied with pushback palatoplasty, would this present a better result in terms of tissue fistulation and phonetic impairment? A series of 74 different degrees of palatal clefts were operated by pushback palatoplasty combined with a modified approach of the levator vili palatini. This muscle was dissected only from the oral mucosa while kept attached to the nasal one as a musculo-nasomucosal unit. This unit was completely detached from the bony margin of the hard palate and then medially rotated and retropositioned in a typical C-shape mobile sling. Evaluations included suture line assessment and fistula development, and following the child's need for speech therapy. There were no intraoperative complications. Definite anterior fistulae with nasal air and foot leakage were observed in 2 cases. Four cases had postoperative velopharyngeal incompetence with a need for speech therapy. Tension-free closure, lower risk of fistula, good restoration of velopharyngeal functions, ability to be performed on all cleft types, ability to provide a good intraoperative exposure, and being a single stage seem to be the most important advantages of this unpublished technique.

  12. The responsible subject in the global age.

    PubMed

    Pulcini, Elena

    2010-09-01

    The first thesis of this article is that the concept of responsibility takes on an unprecedented meaning in the twentieth century resulting from the emergence of a new dimension of the other: to be responsible comes to mean not just to account for oneself in relation to the other, but also to take the other into account, to take care of the other-what I call responsibility towards (the other). The main reason for this change consists in the emergence of global risks and the necessity, as underlined by Hans Jonas, to be responsible for the destiny of the world and future generations. The problem, as explored in the article's second thesis, is that this implies the existence of a subject who is capable of responsibility. Jonas's insights on this point are insufficient, since he only recognizes duty as the fundament for his ethics of responsibility and thus neglects the problem of motivation. This is a particularly crucial problem today as we are witnessing the presence of a pathological subject, characterized by a split in his faculties (between doing and imagining, knowing and feeling). To underline this fact, this article makes use of Günther Anders's reflections, which provide a psycho-anthropological analysis of the subject, showing his pathologies and the necessity, from a moral perspective, to overcome his scission. Finally, this author suggests, as the article's third thesis, that this overcoming is the necessary fundament for the perception of risk, which in turn reinstates the subject's perception of his own vulnerability. Responsibility thus finds a motivation, which is neither altruistic nor duty-centred, in the awareness of our own vulnerability and the bond with the destiny of humankind as a whole.

  13. Symmetries in Physics

    NASA Astrophysics Data System (ADS)

    Brading, Katherine; Castellani, Elena

    2010-01-01

    Preface; Copyright acknowledgements; List of contributors; 1. Introduction; Part I. Continuous Symmetries: 2. Classic texts: extracts from Weyl and Wigner; 3. Review paper: On the significance of continuous symmetry to the foundations of physics C. Martin; 4. The philosophical roots of the gauge principle: Weyl and transcendental phenomenological idealism T. Ryckman; 5. Symmetries and Noether's theorems K. A. Brading and H. R. Brown; 6. General covariance, gauge theories, and the Kretschmann objection J. Norton; 7. The interpretation of gauge symmetry M. Redhead; 8. Tracking down gauge: an ode to the constrained Hamiltonian formalism J. Earman; 9. Time-dependent symmetries: the link between gauge symmetries and indeterminism D. Wallace; 10. A fourth way to the Aharanov-Bohm effect A. Nounou; Part II. Discrete Symmetries: 11. Classic texts: extracts from Lebniz, Kant and Black; 12. Review paper: Understanding permutation symmetry S. French and D. Rickles; 13. Quarticles and the identity of discernibles N. Hugget; 14. Review paper: Handedness, parity violation, and the reality of space O. Pooley; 15. Mirror symmetry: what is it for a relational space to be orientable? N. Huggett; 16. Physics and Leibniz's principles S. Saunders; Part III. Symmetry Breaking: 17: Classic texts: extracts from Curie and Weyl; 18. Extract from G. Jona-Lasinio: Cross-fertilization in theoretical physics: the case of condensed matter and particle physics G. Jona-Lasinio; 19. Review paper: On the meaning of symmetry breaking E. Castellani; 20. Rough guide to spontaneous symmetry breaking J. Earman; 21. Spontaneous symmetry breaking: theoretical arguments and philosophical problems M. Morrison; Part IV. General Interpretative Issues: 22. Classic texts: extracts from Wigner; 23. Symmetry as a guide to superfluous theoretical structure J. Ismael and B. van Fraassen; 24. Notes on symmetries G. Belot; 25. Symmetry, objectivity, and design P. Kosso; 26. Symmetry and equivalence E. Castellani.

  14. Human-induced geomorphology: Modeling slope failure in Dominical, Costa Rica using Landsat imagery

    NASA Astrophysics Data System (ADS)

    Miller, Andrew J.

    Unchecked human development has ravaged the region between Dominical and Uvita, Costa Rica. Much of the development transition has been driven by tourism and further foreign direct investment in residential, service and commercial enterprises. The resulting land-use/land-cover change has removed traditional forest cover in exchange for impervious surfaces, physical structures, and bare ground which is no longer mechanically supported by woody vegetation. Combined with a tropical climate, deeply weathered soils and lithography which are prone to erosion, land cover change has led to an increase in slope failure occurrences. Given the remoteness of the Dominical-Uvita region, its rate of growth and the lack of monitoring, new techniques for monitoring land use and slope failure susceptibility are needed. Two new indices are presented here that employ a Digital Elevation Model (DEM) and widely available Landsat imagery to assist in this endeavor. The first index, or Vegetation Influenced Landslide Index (VILI), incorporates slope derived from a DEM and Lu et al.'s (2007) Surface Cover Index to quantify vegetative cover as a means of mechanical stabilization in landslide prone areas. The second index, or Slope Multiplier Index (SMI), uses individual Landsat data bands and basic Landsat band ratios as environmental proxies to replicate soil, vegetative and hydrologic properties. Both models achieve accuracy over 70% and rival results from more complicated published literature. The accuracy of the indices was assessed with the creation of a landslide inventory developed from field observations occurring in December 2007 and November 2008. The creation of these indices represents an efficient and accurate way of determining landslide susceptibility zonation in data poor areas where environmental protection practitioners may be overextended, under-trained or both.

  15. Objective screening for cervical cancer in developing nations: lessons from Nigeria.

    PubMed

    Roblyer, Darren; Richards-Kortum, Rebecca; Park, Sun-Young; Adewole, Isaac; Follen, Michele

    2007-10-01

    In developed countries, cervical cancer screening programs have been highly successful. In the United States a 70% decrease in the mortality of cervical cancer has occurred since the 1960's largely due to the Papanicolaou test. However, it is not clear how best to translate these advances to developing countries, where cervical cancer remains the leading cause of cancer death for woman. Cytology-based screening, followed by colposcopic detection is expensive and requires extensive laboratory infrastructure and trained personnel, which are often unavailable in low resource settings. Techniques such as visual inspection with acetic acid (VIA) and visual inspection with Lugol's Iodine (VILI) are less expensive and require minimal supplies and infrastructure; however there are concerns that these approaches do not have adequate specificity without extensive provider training and experience. Objective cervical cancer screening techniques which are easy to interpret, provide rapid results, and have both high sensitivity and specificity would be highly beneficial in developing countries. We have developed a multispectral digital colposcope (MDC) which is designed to rapidly image the cervix and is used with automated image analysis algorithms that provide objective delineation of neoplastic areas. In this paper we describe an effort to implement this device in Ibadan, Nigeria, to determine the feasibility of conducting clinical trials using the MDC as an experimental screening device. Our aim was to test the device in a location where it might be most beneficial and to collect data useful for developing new, low-cost, low-maintenance devices. Multiple obstacles limited the success of imaging using the MDC in Nigeria including an unstable supply of electricity and a lack of available spare parts and tools. We conclude that these obstacles must be overcome by robust and simple device designs in order to successfully test an imaging-based screening device in Nigeria or other

  16. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.

    PubMed

    Mathew, Biji; Takekoshi, Daisuke; Sammani, Saad; Epshtein, Yulia; Sharma, Rajesh; Smith, Brett D; Mitra, Sumegha; Desai, Ankit A; Weichselbaum, Ralph R; Garcia, Joe G N; Jacobson, Jeffrey R

    2015-12-15

    We previously reported protective effects of GADD45a (growth arrest and DNA damage-inducible gene 45 alpha) in murine ventilator-induced lung injury (VILI) via effects on Akt-mediated endothelial cell signaling. In the present study we investigated the role of GADD45a in separate murine models of radiation- and bleomycin-induced lung injury. Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a(-/-)) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a(-/-) mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt(+/-) mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. Additionally, overexpression of a constitutively active Akt1 transgene reversed RILI-susceptibility in GADD45a(-/-) mice. In separate studies, lung fibrotic changes 2 wk after treatment with bleomycin (0.25 U/kg IT) was significantly increased in GADD45a(-/-) mice compared with wild-type mice assessed by lung collagen content and histology. These data implicate GADD45a as an important modulator of lung inflammatory responses across different injury models and highlight GADD45a-mediated signaling as a novel target in inflammatory lung injury clinically.

  17. Investigation of alveolar tissue deformations using OCT combined with fluorescence microscopy

    NASA Astrophysics Data System (ADS)

    Gaertner, Maria; Cimalla, Peter; Knels, Lilla; Meissner, Sven; Schnabel, Christian; Kuebler, Wolfgang M.; Koch, Edmund

    2011-06-01

    In critical care medicine, artificial ventilation is a life saving tool providing sufficient blood oxygenation to patients suffering from respiratory failure. Essential for their survival is the use of protective ventilation strategies to prevent further lung damage due to ventilator induced lung injury (VILI). Since there is only little known about implications of lung tissue overdistension on the alveolar level, especially in the case of diseased lungs, this research deals with the investigation of lung tissue deformation on a microscale. A combined setup utilizing optical coherence tomography (OCT) and confocal fluorescence microscopy, is used to study the elastic behavior of the alveolar tissue. Three-dimensional geometrical information with voxel sizes of 6 μm × 6 μm × 11 μm (in air) is provided by OCT, structural information about localization of elastin fibers is elucidated via confocal fluorescence microscopy with a lateral resolution of around 1 μm. Imaging depths of 90 μm for OCT and 20 μm for confocal fluorescence microscopy were obtained. Dynamic studies of subpleural tissue were carried out on the basis of an in vivo mouse model post mortem, mimicking the physiological environment of an intact thorax and facilitating a window for the application of optical methods. Morphological changes were recorded by applying constant positive airway pressures of different values. With this, alveolar volume changes could clearly be recognized and quantified to form a compliance value of 3.5 • 10-6(see manuscript). The distribution of elastin fibers was detected and will be subject to further elasticity analysis.

  18. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury

    PubMed Central

    Mathew, Biji; Takekoshi, Daisuke; Sammani, Saad; Epshtein, Yulia; Sharma, Rajesh; Smith, Brett D.; Mitra, Sumegha; Desai, Ankit A.; Weichselbaum, Ralph R.; Garcia, Joe G. N.

    2015-01-01

    We previously reported protective effects of GADD45a (growth arrest and DNA damage-inducible gene 45 alpha) in murine ventilator-induced lung injury (VILI) via effects on Akt-mediated endothelial cell signaling. In the present study we investigated the role of GADD45a in separate murine models of radiation- and bleomycin-induced lung injury. Initial studies of wild-type mice subjected to single-dose thoracic radiation (10 Gy) confirmed a significant increase in lung GADD45a expression within 24 h and persistent at 6 wk. Mice deficient in GADD45a (GADD45a−/−) demonstrated increased susceptibility to radiation-induced lung injury (RILI, 10 Gy) evidenced by increased bronchoalveolar lavage (BAL) fluid total cell counts, protein and albumin levels, and levels of inflammatory cytokines compared with RILI-challenged wild-type animals at 2 and 4 wk. Furthermore, GADD45a−/− mice had decreased total and phosphorylated lung Akt levels both at baseline and 6 wk after RILI challenge relative to wild-type mice while increased RILI susceptibility was observed in both Akt+/− mice and mice treated with an Akt inhibitor beginning 1 wk prior to irradiation. Additionally, overexpression of a constitutively active Akt1 transgene reversed RILI-susceptibility in GADD45a−/− mice. In separate studies, lung fibrotic changes 2 wk after treatment with bleomycin (0.25 U/kg IT) was significantly increased in GADD45a−/− mice compared with wild-type mice assessed by lung collagen content and histology. These data implicate GADD45a as an important modulator of lung inflammatory responses across different injury models and highlight GADD45a-mediated signaling as a novel target in inflammatory lung injury clinically. PMID:26498248

  19. Amelioration of superoxide dismutase on ventilator-induced lung injury by suppressing leukocyte in the lungs and systemic circulation.

    PubMed

    Su, Chien-Ling; Du, Wen-Yuan; Chiang, Ling-Ling; Lin, Yen-Kuang; Lee, Hui-Ling; Chen, Kuan-Hao; Wang, Jiun-; Wang, David

    2013-08-31

    Superoxide dismutase (SOD) is a free radical scavenger and a broad-spectrum antioxidant. Its anti-inflammatory and immunomodulatory effects have recently been noted. We studied the effects of this antioxidant on lung damage, oxidative stress, and inflammation in a model of ventilator-induced lung injury (VILI), using 8- to 12-wk-old Sprange-Dawley rats (n = 40). Animals were randomized and evenly divided into two experimental groups, low tidal volume (V(T)) ventilation (V(T) = 9 ml/kg) and high V(T) ventilation (V(T) = 28 ml/kg). Each group was evenly divided into two subgroups: ten animals were treated with superoxide dismutase (SOD; 10,000 U/kg i.v., 2 h prior to the ventilation) and the rests were treated with vehicle. Lung injury was evaluated by histological examination, and cells counts of red blood cells (RBC) and white blood cells (WBC) in the alveoli and the septal wall thickness in lung tissues and serum lactate dehydrogenase (LDH). The lung permeability was assessed by the wet-to-dry weight ratio (W/D), lung weight to body weight ratio (LW/BW) and protein concentration in broncholavage fluid (BALF). Levels of oxidative stress and lipid peroxidation in the lungs were evaluated by tissue malondialdehyde (MDA) and methylguanidine (MG) in BALF, respectively. SOD pretreatment significantly decreased WBC counts in systemic circulation and in alveoli, and effectively attenuated high V(T) ventilation induced lung injury by reducing hyaline membrane development, septal wall thickness, lung W/D and LW/BW and serum LDH in relation to those of the control. In addition, lung tissues MDA and MG in BALF were also notably reduced.

  20. Web-based interactive access, analysis and comparison of remotely sensed and in situ measured temperature data

    NASA Astrophysics Data System (ADS)

    Eberle, Jonas; Urban, Marcel; Hüttich, Christian; Schmullius, Christiane

    2014-05-01

    Numerous datasets providing temperature information from meteorological stations or remote sensing satellites are available. However, the challenging issue is to search in the archives and process the time series information for further analysis. These steps can be automated for each individual product, if the pre-conditions are complied, e.g. data access through web services (HTTP, FTP) or legal rights to redistribute the datasets. Therefore a python-based package was developed to provide data access and data processing tools for MODIS Land Surface Temperature (LST) data, which is provided by NASA Land Processed Distributed Active Archive Center (LPDAAC), as well as the Global Surface Summary of the Day (GSOD) and the Global Historical Climatology Network (GHCN) daily datasets provided by NOAA National Climatic Data Center (NCDC). The package to access and process the information is available as web services used by an interactive web portal for simple data access and analysis. Tools for time series analysis were linked to the system, e.g. time series plotting, decomposition, aggregation (monthly, seasonal, etc.), trend analyses, and breakpoint detection. Especially for temperature data a plot was integrated for the comparison of two temperature datasets based on the work by Urban et al. (2013). As a first result, a kernel density plot compares daily MODIS LST from satellites Aqua and Terra with daily means from GSOD and GHCN datasets. Without any data download and data processing, the users can analyze different time series datasets in an easy-to-use web portal. As a first use case, we built up this complimentary system with remotely sensed MODIS data and in situ measurements from meteorological stations for Siberia within the Siberian Earth System Science Cluster (www.sibessc.uni-jena.de). References: Urban, Marcel; Eberle, Jonas; Hüttich, Christian; Schmullius, Christiane; Herold, Martin. 2013. "Comparison of Satellite-Derived Land Surface Temperature and Air

  1. Is the snow of yesterday, the flood of tomorrow?

    NASA Astrophysics Data System (ADS)

    Rössler, Ole; Weingartner, Rolf

    2014-05-01

    "The snow of yesterday, is the flood of tomorrow." This famous quote could just as much be a folk wisdom or a farmer's wisdom, but it describes the social awareness that the water of the winterly snow amounts may lead to flooding in the spring. Furthermore, this common experience finds its confirmation in reality - though only at a first glance. For example, in spring 1999, a major flooding occurred after a winter with the highest snow amounts recorded over the last 30 years. This is to forget that sustained rainfall occurred prior to the flood event. For scientists, the question remains whether and to what extent winterly snow contributes to spring flooding and how this information might help in forecasts. As snow depth measurements are insufficiently for an empirical study, we set up a hydrological model approach, combining the various snow conditions with the different spring weather conditions of the last 29 years (1981-2009). The study was conducted in three mesoscale (380-550 km2) headwater catchments in the Bernese Oberland. We set up the hydrological model WaSiM-ETH and validated the model against runoff and snow water equivalent. Then, we estimated the start of the melting season for each year following the approach of Egli and Jonas (2009). This date and the according SWE serves as the initial condition to model the spring runoff using all weather conditions during the last 29 years (until June). This leads to 841 possible spring runoff series. Assuming that the last 29 years represent a major part of the natural variance, the influence of snow on the spring discharge and the flood peak in specific is presented. We found that the snow amount and the flood peak are not directly correlated as suggested by the saying. But, the snow amount causes primarily higher mean flow values while the effect on spring flood peaks are a function of weather. Thereby, snow conditions primarily alter the disposition of the catchments to a flood event. We estimate the

  2. Reduction of adsorption capacity of coconut shell activated carbon for organic vapors due to moisture contents.

    PubMed

    Abiko, Hironobu; Furuse, Mitsuya; Takano, Tsuguo

    2010-01-01

    In occupational hygiene, activated carbon produced from coconut shell is a common adsorbent material for harmful substances including organic vapors due to its outstanding adsorption capacity and cost advantage. However, moisture adsorption of the carbon generally decreases the adsorption capacity for organic vapors. In a previous report, we prepared several coconut shell activated carbons which had been preconditioned by equilibration with moisture at different relative humidities and measured the breakthrough times for 6 kinds of organic vapor, in order to clarify the effect of preliminary moisture content in activated carbon on the adsorption capacity in detail. We found that the relative percent weight increase due to moisture adsorption of the carbon specimen had a quantitative effect, reducing the breakthrough time. In this report, we carried out further measurements of the effect of moisture content on the adsorption of 13 kinds of organic vapor, and investigated the relationship between moisture adsorption and the reduction of the breakthrough time of activated carbon specimens. We also applied the data to the Wood's breakthrough time estimation model which is an extension of the Wheeler-Jonas equation.

  3. Current Fluctuations in One Dimensional Diffusive Systems with a Step Initial Density Profile

    NASA Astrophysics Data System (ADS)

    Derrida, Bernard; Gerschenfeld, Antoine

    2009-12-01

    We show how to apply the macroscopic fluctuation theory (MFT) of Bertini, De Sole, Gabrielli, Jona-Lasinio, and Landim to study the current fluctuations of diffusive systems with a step initial condition. We argue that one has to distinguish between two ways of averaging (the annealed and the quenched cases) depending on whether we let the initial condition fluctuate or not. Although the initial condition is not a steady state, the distribution of the current satisfies a symmetry very reminiscent of the fluctuation theorem. We show how the equations of the MFT can be solved in the case of non-interacting particles. The symmetry of these equations can be used to deduce the distribution of the current for several other models, from its knowledge (Derrida and Gerschenfeld in J. Stat. Phys. 136, 1-15, 2009) for the symmetric simple exclusion process. In the range where the integrated current Qt˜sqrt{t} , we show that the non-Gaussian decay exp [- Q {/t 3}/ t] of the distribution of Q t is generic.

  4. Quark matter symmetry energy and quark stars

    SciTech Connect

    Chu, Peng-Cheng; Chen, Lie-Wen

    2014-01-10

    We extend the confined-density-dependent-mass (CDDM) model to include isospin dependence of the equivalent quark mass. Within the confined-isospin-density-dependent-mass (CIDDM) model, we study the quark matter symmetry energy, the stability of strange quark matter, and the properties of quark stars. We find that including isospin dependence of the equivalent quark mass can significantly influence the quark matter symmetry energy as well as the properties of strange quark matter and quark stars. While the recently discovered large mass pulsars PSR J1614–2230 and PSR J0348+0432 with masses around 2 M {sub ☉} cannot be quark stars within the CDDM model, they can be well described by quark stars in the CIDDM model. In particular, our results indicate that the two-flavor u-d quark matter symmetry energy should be at least about twice that of a free quark gas or normal quark matter within the conventional Nambu-Jona-Lasinio model in order to describe PSR J1614–2230 and PSR J0348+0432 as quark stars.

  5. Critical Stability in Nuclei - An Old Problem Revisited

    NASA Astrophysics Data System (ADS)

    Moszkowski, S. A.

    In this paper we will focus on the nucleon-nucleon interaction in relative S-states. The 1S0 interaction is known to be close to that for critical two-body binding. We will discuss two approaches to the NN interaction, which are equivalent on-shell but not off-shell. There is a well-defined transformation between these approaches [1]. One (my preferred approach) is to minimize the tensor forces far off-shell, which leads to more rapid convergence, but at the price of significant non-locality. This approach is used in a model of relativistic tensor quenching of OPEP [2]. With non-local NN interactions it is possible to fit not only NN observables, but also the NNN ground-state energies [3]. The other approach is to maximize the role of the π and keep the interaction as local as possible [4]. This approach is also internally consistent, but requires additional NNN interactions to fit nuclear data. Also, we discuss briefly a so-called low momentum interaction [5, 6], which fits S-wave phase shifts quite well. This interaction is strongly non-local, and it can be approximated by a schematic separable interaction. Finally, we mention the Nambu-Jona-Lasinio model [7] and a good approximation, the Hulthen potential, which provides some insight into the near critical two-body binding.

  6. Flavor dependence of quasi Nambu-Goldstone fermion masses

    NASA Astrophysics Data System (ADS)

    Yasuè, Masaki; Terazawa, Hidezumi

    1987-10-01

    A possible flavor dependence of masses for light quasi Nambu-Goldstone fermions (QNGF's) is examined in a supersymmetric (SUSY) nonlinear-interaction model of the Nambu-Jona-Lasinio type with SO(2N, C)-->SO(n, C)×SO(2N-n, C) by ~Λ2, in which subquarks (Ai, ψi)a (a=1, 2; i=1, ..., 2N) belong to 2N. SUSY is broken by scalar mass terms, μi2Ai(a)2and μi2Ai(1)Ai(2) (μi, μi <<Λ). The masses of the QNGF's, MQNGF, are controlled by MiSS2=μi2+cμi2: MQNGF=mF+fMiSS2+gMjSS with mF=O(MSS2/Λ), f, g=O(Λ-1) and c=O(1) for i in SO(n) and j in SO(2N-n). A large mass splitting between QNGF's and (pseudo Nambu-Goldstone bosons ((P)NGB's): MQNGF/M(P)NGB = O(MSS/Λ) << 1 is shown to arise.

  7. "A different kind of beauty": scientific and architectural style in I.M. Pei's Mesa Laboratory and Louis Kahn's Salk Institute.

    PubMed

    Leslie, Stuart W

    2008-01-01

    I.M. Pei's Mesa Laboratory for the National Center for Atmospheric Research in Boulder, Colorado, and Louis Kahn's Salk Institute in La Jolla, California, are rare examples of laboratories as celebrated for their architecture as for their scientific contributions. Completed in the mid-1960s, these signature buildings still express the scientific style of their founding directors, Walter Roberts and Jonas Salk. yet in commissioning their laboratories, Roberts and Salk had to work with architects as strong-willed as themselves. A close reading of the two laboratories reveals the ongoing negotiations and tensions in collaborations between visionary scientist and visionary architect. Moreover, Roberts and Salk also had to become architects of atmospheric and biomedical sciences. For laboratory architecture, however flexible in theory, necessarily stabilizes scientific practice, since a philosophy of research is embedded in the very structure of the building and persists far longer than the initial vision and mission that gave it life. Roberts and Salk's experiences suggest that even the most carefully designed laboratories must successfully adapt to new disciplinary configurations, funding opportunities, and research priorities, or risk becoming mere architectural icons.

  8. WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling.

    PubMed

    Shcherbina, Anna; Cooley, Jessica; Lutskiy, Maxim I; Benarafa, Charaf; Gilbert, Gary E; Remold-O'Donnell, Eileen

    2010-02-01

    The most consistent feature of Wiskott Aldrich syndrome (WAS) is profound thrombocytopenia with small platelets. The responsible gene encodes WAS protein (WASP), which functions in leucocytes as an actin filament nucleating agent -yet- actin filament nucleation proceeds normally in patient platelets regarding shape change, filopodia and lamellipodia generation. Because WASP localizes in the platelet membrane skeleton and is mobilized by alphaIIbbeta3 integrin outside-in signalling, we questioned whether its function might be linked to integrin. Agonist-induced alphaIIbbeta3 activation (PAC-1 binding) was normal for patient platelets, indicating normal integrin inside-out signalling. Inside-out signalling (fibrinogen, JON/A binding) was also normal for wasp-deficient murine platelets. However, adherence/spreading on immobilized fibrinogen was decreased for patient platelets and wasp-deficient murine platelets, indicating decreased integrin outside-in responses. Another integrin outside-in dependent response, fibrin clot retraction, involving contraction of the post-aggregation actin cytoskeleton, was also decreased for patient platelets and wasp-deficient murine platelets. Rebleeding from tail cuts was more frequent for wasp-deficient mice, suggesting decreased stabilisation of the primary platelet plug. In contrast, phosphatidylserine exposure, a pro-coagulant response, was enhanced for WASP-deficient patient and murine platelets. The collective results reveal a novel function for WASP in regulating pro-aggregatory and pro-coagulant responses downstream of integrin outside-in signalling.

  9. Isoscalar-vector interaction and hybrid quark core in massive neutron stars

    NASA Astrophysics Data System (ADS)

    Shao, G. Y.; Colonna, M.; Di Toro, M.; Liu, Y. X.; Liu, B.

    2013-05-01

    The hadron-quark phase transition in the core of massive neutron stars is studied with a newly constructed two-phase model. For nuclear matter, a nonlinear Walecka type model with general nucleon-meson and meson-meson couplings, recently calibrated by Steiner, Hemper and Fischer, is taken. For quark matter, a modified Polyakov-Nambu—Jona-Lasinio model, which gives consistent results with lattice QCD data, is used. Most importantly, we introduce an isoscalar-vector interaction in the description of quark matter, and we study its influence on the hadron-quark phase transition in the interior of massive neutron stars. With the constraints of neutron star observations, our calculation shows that the isoscalar-vector interaction between quarks is indispensable if massive hybrids star exist in the universe, and its strength determines the onset density of quark matter, as well as the mass-radius relations of hybrid stars. Furthermore, as a connection with heavy-ion-collision experiments we give some discussions about the strength of isoscalar-vector interaction and its effect on the signals of hadron-quark phase transition in heavy-ion collisions, in the energy range of the NICA at JINR-Dubna and FAIR at GSI-Darmstadt facilities.

  10. Dual use and the ethical responsibility of scientists.

    PubMed

    Ehni, Hans-Jörg

    2008-01-01

    The main normative problem in the context of dual use is to determine the ethical responsibility of scientists especially in the case of unintended, harmful, and criminal dual use of new technological applications of scientific results. This article starts from an analysis of the concepts of responsibility and complicity, examining alternative options regarding the responsibility of scientists. Within the context of the basic conflict between the freedom of science and the duty to avoid causing harm, two positions are discussed: moral skepticism and the ethics of responsibility by Hans Jonas. According to these reflections, four duties are suggested and evaluated: stopping research, systematically carrying out research for dual-use applications, informing public authorities, and not publishing results. In the conclusion it is argued that these duties should be considered as imperfect duties in a Kantian sense and that the individual scientist should be discharged as much as possible from obligations which follow from them by the scientific community and institutions created for this purpose.

  11. Equilibrium sequences of nonrotating and rapidly rotating crystalline color-superconducting hybrid stars

    NASA Astrophysics Data System (ADS)

    Ippolito, Nicola D.; Ruggieri, Marco; Rischke, Dirk H.; Sedrakian, Armen; Weber, Fridolin

    2008-01-01

    The three-flavor crystalline color-superconducting (CCS) phase of quantum chromodynamics (QCD) is a candidate phase for the ground state of cold matter at moderate densities above the density of the deconfinement phase transition. Apart from being a superfluid, the CCS phase has properties of a solid, such as a lattice structure and a shear modulus, and hence the ability to sustain multipolar deformations in gravitational equilibrium. We construct equilibrium configurations of hybrid stars composed of nuclear matter at low, and CCS quark matter at high, densities. Phase equilibrium between these phases is possible only for rather stiff equations of state of nuclear matter and large couplings in the effective Nambu—Jona-Lasinio Lagrangian describing the CCS state. We identify a new branch of stable CCS hybrid stars within a broad range of central densities which, depending on the details of the equations of state, either bifurcate from the nuclear sequence of stars when the central density exceeds that of the deconfinement phase transition or form a new family of configurations separated from the purely nuclear sequence by an instability region. The maximum masses of our nonrotating hybrid configurations are consistent with the presently available astronomical bounds. The sequences of hybrid configurations that rotate near the mass-shedding limit are found to be more compact and thus support substantially larger spins than their same mass nuclear counterparts.

  12. Vaccines today, vaccines tomorrow: a perspective

    PubMed Central

    2013-01-01

    Vaccines are considered as one of the major contributions of the 20th century and one of the most cost effective public health interventions. The International Vaccine Institute has as a mission to discover, develop and deliver new and improved vaccines against infectious diseases that affects developing nations. If Louis Pasteur is known across the globe, vaccinologists like Maurice Hilleman, Jonas Salk and Charles Mérieux are known among experts only despite their contribution to global health. Thanks to a vaccine, smallpox has been eradicated, polio has nearly disappeared, Haemophilus influenzae B, measles and more recently meningitis A are controlled in many countries. While a malaria vaccine is undergoing phase 3, International Vaccine Institute, in collaboration with an Indian manufacturer has brought an oral inactivated cholera vaccine to pre-qualification. The field of vaccinology has undergone major changes thanks to philanthropists such as Bill and Melinda Gates, initiatives like the Decade of Vaccines and public private partnerships. Current researches on vaccines have more challenging targets like the dengue viruses, malaria, human immunodeficiency virus, the respiratory syncytial virus and nosocomial diseases. Exciting research is taking place on new adjuvants, nanoparticles, virus like particles and new route of administration. An overcrowded infant immunization program, anti-vaccine groups, immunizing a growing number of elderlies and delivering vaccines to difficult places are among challenges faced by vaccinologists and global health experts. PMID:23596584

  13. The Chiral Quark Soliton Model for the Nucleon

    NASA Astrophysics Data System (ADS)

    Watabe, T.; Toki, H.

    1992-03-01

    We study the chiral invariant quark model lagrangians under the Hartree approximation for construction of a hedgehog solution with the baryon number B = 1. We take into account the Dirac sea contributions to the energy and various densities in terms of the heat-kernel method. With the parameters of the Nambu-Jona-Lasinio model lagrangian fixed by the meson properties, we do not find any B = 1 hedgehog solutions except for one case, even which is, however, unstable against small perturbation. We study then the Diakonov-Petrov model lagrangian, which is introduced by investigating the properties of the quark field in the instanton background in QCD. We find in this case stable hedgehog solutions under the heat-kernel regularization method in some parameter region. We study also the isoscalar-vector type (omega-meson type) correlations among quarks for the nucleon properties. The hedgehog energy, the baryon root mean square radius and the axial vector coupling constant g_{A} are calculated as a function of the omega-quark coupling strength.

  14. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    NASA Astrophysics Data System (ADS)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2016-06-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates ( 10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass ( α ) transition and the secondary ( β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  15. Quark Deconfinement in Rotating Neutron Stars

    NASA Astrophysics Data System (ADS)

    Mellinger, Richard; Weber, Fridolin; Spinella, William; Contrera, Gustavo; Orsaria, Milva

    2017-01-01

    In this paper, we use a three flavor non-local Nambu--Jona-Lasinio (NJL) model, an~improved effective model of Quantum Chromodynamics (QCD) at low energies, to investigate the existence of deconfined quarks in the cores of neutron stars. Particular emphasis is put on the possible existence of quark matter in the cores of rotating neutron stars (pulsars). In contrast to non-rotating neutron stars, whose particle compositions do not change with time (are frozen in), the type and structure of the matter in the cores of rotating neutron stars depends on the spin frequencies of these stars, which opens up a possible new window on the nature of matter deep in the cores of neutron stars. Our study shows that, depending on mass and rotational frequency, up to around 8% of the mass of a massive neutron star may be in the mixed quark-hadron phase, if the phase transition is treated as a Gibbs transition. We also find that the gravitational mass at which quark deconfinement occurs in rotating neutron stars varies quadratically with spin frequency, which can be fitted by a simple formula.

  16. Estimating transport coefficients in hot and dense quark matter

    NASA Astrophysics Data System (ADS)

    Deb, Paramita; Kadam, Guru Prakash; Mishra, Hiranmaya

    2016-11-01

    We compute the transport coefficients, namely, the coefficients of shear and bulk viscosity, as well as thermal conductivity, for hot and dense quark matter. The calculations are performed within the Nambu-Jona-Lasinio (NJL) model. The estimation of the transport coefficients is made using a quasiparticle approach of solving the Boltzmann kinetic equation within the relaxation time approximation. The transition rates are calculated in a manifestly covariant manner to estimate the thermal-averaged cross sections for quark-quark and quark-antiquark scattering. The calculations are performed for finite chemical potential also. Within the parameters of the model, the ratio of shear viscosity to entropy density has a minimum at the Mott transition temperature. At vanishing chemical potential, the ratio of bulk viscosity to entropy density, on the other hand, decreases with temperature, with a sharp decrease near the critical temperature, and vanishes beyond it. At finite chemical potential, however, it increases slowly with temperature beyond the Mott temperature. The coefficient of thermal conductivity also shows a minimum at the critical temperature.

  17. Interacting fermions in rotation: chiral symmetry restoration, moment of inertia and thermodynamics

    NASA Astrophysics Data System (ADS)

    Chernodub, M. N.; Gongyo, Shinya

    2017-01-01

    We study rotating fermionic matter at finite temperature in the framework of the Nambu-Jona-Lasinio model. In order to respect causality the rigidly rotating system must be bound by a cylindrical boundary with appropriate boundary conditions that confine the fermions inside the cylinder. We show the finite geometry with the MIT boundary conditions affects strongly the phase structure of the model leading to three distinct regions characterized by explicitly broken (gapped), partially restored (nearly gapless) and spontaneously broken (gapped) phases at, respectively, small, moderate and large radius of the cylinder. The presence of the boundary leads to specific steplike irregularities of the chiral condensate as functions of coupling constant, temperature and angular frequency. These steplike features have the same nature as the Shubnikov-de Haas oscillations with the crucial difference that they occur in the absence of both external magnetic field and Fermi surface. At finite temperature the rotation leads to restoration of spontaneously broken chiral symmetry while the vacuum at zero temperature is insensitive to rotation ("cold vacuum cannot rotate"). As the temperature increases the critical angular frequency decreases and the transition becomes softer. A phase diagram in angular frequency-temperature plane is presented. We also show that at fixed temperature the fermion matter in the chirally restored (gapless) phase has a higher moment of inertia compared to the one in the chirally broken (gapped) phase.

  18. Believing doesn't make it so: forensic education and the search for truth.

    PubMed

    Scott, Charles L

    2013-01-01

    The American Academy of Psychiatry and the Law (AAPL) was organized in 1969, in large part through the efforts of Dr. Jonas Rappeport. The founders of AAPL emphasized that an important purpose of the organization was to advance knowledge in the area of psychiatry and the law. The science of forensic psychiatry has since been vigorously debated. In 2005, Congress enacted a statute authorizing the National Academy of Sciences (NAS) to conduct a study on the state of the forensic sciences in the United States. As a result of this legislation, a forensic science committee was formed, and the report, "Strengthening Forensic Science in the United States: A Path Forward," was produced, emphasizing the need for research in the forensic disciplines, particularly those that rely on more subjective assessments. The committee also identified two important factors relevant to standards of evidence admissibility: the scientific methodology used and the impact of bias on the interpretation of data. In this article, I apply the NAS committee's findings to the field of forensic psychiatry, with specific recommendations to assist educators in achieving more objective assessment methodologies, critical in forensic education and the search for truth.

  19. Influence of pions on the hadron-quark phase transition

    SciTech Connect

    Lourenco, O.; Dutra, M.; Frederico, T.; Malheiro, M.; Delfino, A.

    2013-05-06

    In this work we present the features of the hadron-quark phase transition diagrams in which the pions are included in the system. To construct such diagrams we use two different models in the description of the hadronic and quark sectors. At the quark level, we consider two distinct parametrizations of the Polyakov-Nambu-Jona-Lasinio (PNJL) models. In the hadronic side, we use a well known relativistic mean-field (RMF) nonlinear Walecka model. We show that the effect of the pions on the hadron-quark phase diagrams is to move the critical end point (CEP) of the transitions lines. Such an effect also depends on the value of the critical temperature (T{sub 0}) in the pure gauge sector used to parametrize the PNJL models. Here we treat the phase transitions using two values for T{sub 0}, namely, T{sub 0}= 270 MeV and T{sub 0}= 190 MeV. The last value is used to reproduce lattice QCD data for the transition temperature at zero chemical potential.

  20. [Sigmund Freud and the "Zeitschrift für Hypnotismus"].

    PubMed

    Tanner, Terence A

    2005-01-01

    While Freud was always ready to acknowledge the debt that psychoanalysis owed to hypnotism, his engagement in its study and medical application is often seen by historians as little more than a passing phase on the way to psychoanalysis proper. This paper attempts to redress the balance by exploring Freud's association with the most influential German-language journal devoted to hypnotism, the Zeitschrift für Hypnotismus. Freud not only contributed a paper to this periodical but also served on its editorial board for the first three years of its existence. There also appeared in the journal one review and six abstracts of his work. After a condensed bibliographical account of the journal, a summary is given of Freud's intellectual and professional contacts and exchanges with three of the key individuals associated with it: August Forel, Jonas Grossmann and Oskar Vogt. Finally clarification is given of the publication history of the "Dora" case history and the chronology of its rejection for publication by Korbinian Brodmann, editor of the journal when it became the Journal für Psychologie und Neurologie.

  1. Immunology in Pittsburgh.

    PubMed

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time.

  2. Dual condensates at finite isospin chemical potential

    NASA Astrophysics Data System (ADS)

    Zhang, Zhao; Miao, Qing

    2016-02-01

    The dual observables as order parameters for center symmetry are tested at finite isospin chemical potential μI in a Polyakov-loop enhanced chiral model of QCD with physical quark masses. As a counterpart of the dressed Polyakov-loop, the first Fourier moment of pion condensate is introduced for μI >mπ / 2 under the temporal twisted boundary conditions for quarks. We demonstrate that this dual condensate exhibits the similar temperature dependence as the conventional Polyakov-loop. We confirm that its rapid increase with T is driven by the evaporating of pion condensation. On the other hand, the dressed Polyakov-loop shows abnormal thermal behavior, which even decreases with T at low temperatures due to the influence of pion condensate. We also find that the dressed Polyakov-loop always rises most steeply at the chiral transition temperature, which is consistent with the previous results in Nambu-Jona-Lasinio (NJL) model and its variants without considering the center symmetry. Since both quantities are strongly affected by the chiral symmetry and pion condensation, we conclude that it is difficult to clarify the deconfinement transition from the dual condensates in this situation within this model.

  3. Rippled Surface Structure and Electronic and Magnetic Properties of Ni_3Al(001)

    NASA Astrophysics Data System (ADS)

    Lee, Jae Il; Hong, S. C.; Mannstadt, W.; Freeman, A. J.

    1998-03-01

    LEED experiments on the composite Ni-Al surface of Ni_3Al(001) revealed a very small amount of ripplingfootnote D. Sondericker, F. Jona and P. M. Marcus, Phys. Rev. B33, 900 (1986). Challenged by this observation, structural, electronic and magnetic properties of Ni_3Al(001) were investigated by the local density full-potential linearized augmented plane wave (FLAPW) methodfootnote E. Wimmer, H. Krakauer, M. Weinert and A. J. Freeman, Phys. Rev. B24, 864 (1981).. A stable rippled surface atomic geometry was determined by atomic force calculations, with both surface Ni and Al atoms contracting down to the bulk region-consistent with experiment. The amount of rippling found by calculation (0.054 Åis almost within the experimental error bar (0.02 ± 0.03 ÅCharge densities, calculated work functions, and density of states for the rippled surfaces are reported. The spin polarized calculation shows that the magnetic moments for the Ni atoms decrease from 0.2 μB for the center layer to ~ 0.03 μB for the surface layer, which is essentially "magnetically dead". * Work in Korea supported by KOSEF through SNU-CTP and work at Northwestern U. supported by ONR

  4. Collective modes in the color flavor-locked phase.

    SciTech Connect

    Anglani, R.; Mannarelli, M.; Ruggieri, M.

    2011-05-17

    We study the low-energy effective action for some collective modes of the color flavor-locked (CFL) phase of QCD. This phase of matter has long been known to be a superfluid because by picking a phase its order parameter breaks the quark-number U(1){sub B} symmetry spontaneously. We consider the modes describing fluctuations in the magnitude of the condensate, namely the Higgs mode, and in the phase of the condensate, namely the Nambu-Goldstone (NG) (or Anderson-Bogoliubov) mode associated with the breaking of U(1){sub B}. By employing as microscopic theory the Nambu-Jona-Lasinio model, we reproduce known results for the Lagrangian of the NG field to the leading order in the chemical potential and extend such results evaluating corrections due to the gap parameter. Moreover, we determine the interaction terms between the Higgs and the NG field. This study paves the way for a more reliable study of various dissipative processes in rotating compact stars with a quark matter core in the CFL phase.

  5. Meeting report VLPNPV: Sessions 1 and 2: Plenary.

    PubMed

    Sainsbury, Frank

    2014-01-01

    Following the highly successful inaugural meeting in 2012, the second installment of Virus-Like Particles and Nano-Particle Vaccines (VLPNPV), proved to be a worthy follow-up in an outstanding conference series. VLPNPV is a forum for academics and industry to address one of the major areas of need in biomedical sciences, the development of novel prophylactic and therapeutic vaccines. The conference was opened by Professor Marianne Manchester of the University of California, San Diego who pointed to the significance of the site chosen for the conference, the Salk Institute. Founded by Jonas Salk, the Salk Institute for Biological Studies is a non-profit, independent research institute with focuses in molecular biology and genetics, neurosciences, and plant biology. This diversity in research themes reflects the wishes of the institute's founder who saw value in using interdisciplinary approaches to understanding the basic principles in life, aimed at generating new therapies and treatments for human disease. Likewise, interdisciplinarity was reflected in the main themes of the meeting, which also highlight some of the potential advantages of virus-like particle (VLP) and nanoparticle vaccines, including novel formulations/adjuvanting effects, structurally accurate/designed antigens, production systems and capacity, and tailoring the immune response. These themes were covered by the 2 plenary sessions that opened the conference and are described in this report.

  6. QCD phase diagram at finite baryon and isospin chemical potentials

    SciTech Connect

    Sasaki, Takahiro; Sakai, Yuji; Yahiro, Masanobu; Kouno, Hiroaki

    2010-12-01

    The phase structure of two-flavor QCD is explored for thermal systems with finite baryon- and isospin-chemical potentials, {mu}{sub B} and {mu}{sub iso}, by using the Polyakov-loop extended Nambu-Jona-Lasinio (PNJL) model. The PNJL model with the scalar-type eight-quark interaction can reproduce lattice QCD data at not only {mu}{sub iso}={mu}{sub B}=0, but also {mu}{sub iso}>0 and {mu}{sub B}=0. In the {mu}{sub iso}-{mu}{sub B}-T space, where T is temperature, the critical endpoint of the chiral phase transition in the {mu}{sub B}-T plane at {mu}{sub iso}=0 moves to the tricritical point of the pion-superfluidity phase transition in the {mu}{sub iso}-T plane at {mu}{sub B}=0 as {mu}{sub iso} increases. The thermodynamics at small T is controlled by {radical}({sigma}{sup 2}+{pi}{sup 2}) defined by the chiral and pion condensates, {sigma} and {pi}.

  7. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    DOE PAGES

    Azaria, P.; Konik, R. M.; Lecheminant, P.; ...

    2016-08-03

    In our paper we study a (1+1)-dimensional version of the famous Nambu–Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ, is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ=0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phasesmore » with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). Finally, the QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).« less

  8. Particle formation and ordering in strongly correlated fermionic systems: Solving a model of quantum chromodynamics

    SciTech Connect

    Azaria, P.; Konik, R. M.; Lecheminant, P.; Pálmai, T.; Takács, G.; Tsvelik, A. M.

    2016-08-03

    In our paper we study a (1+1)-dimensional version of the famous Nambu–Jona-Lasinio model of quantum chromodynamics (QCD2) both at zero and at finite baryon density. We use nonperturbative techniques (non-Abelian bosonization and the truncated conformal spectrum approach). When the baryon chemical potential, μ, is zero, we describe the formation of fermion three-quark (nucleons and Δ baryons) and boson (two-quark mesons, six-quark deuterons) bound states. We also study at μ=0 the formation of a topologically nontrivial phase. When the chemical potential exceeds the critical value and a finite baryon density appears, the model has a rich phase diagram which includes phases with a density wave and superfluid quasi-long-range (QLR) order, as well as a phase of a baryon Tomonaga-Luttinger liquid (strange metal). Finally, the QLR order results in either a condensation of scalar mesons (the density wave) or six-quark bound states (deuterons).

  9. How can video supported reflection enhance teachers' professional development?

    NASA Astrophysics Data System (ADS)

    McCullagh, John F.

    2012-03-01

    This paper responds to Eva Lundqvist, Jonas Almqvist and Leif Ostman's account of how the manner of teaching can strongly influence pupil learning by recommending video supported reflection as a means by which teachers can transform the nature of their practice. Given the complex nature of the many conditions which influence and control teachers' actions the reframing of routine practice through reflection-in-action can prove challenging. This response paper describes how video can empower teachers to take greater control of their progress and allows for a more social constructivist approach to professional development. Along with a consideration of the difficulties associated with the notion of `reflection' and a short case study, the paper uses Lev Semenovich Vygotsky's zone of proximal development and the notion of scaffolding to propose that video offers a Video Supported Zone of Proximal Development which can ease the process of teacher development. In capturing permanent and exchangeable representations of practice video encourages a collaborative approach to reflection and is consistent with the original ideas of John Dewey.

  10. On the 100th anniversary of sterile catgut kuhn: Franz Kuhn (1866-1929) and the epistemology of catgut sterilization.

    PubMed

    Dietz, Ulrich A; Kehl, Franz; Hamelmann, Wulf; Weisser, Christoph

    2007-12-01

    The long road to effective catgut sterilization began with the work of Lord Joseph Lister (1867) and did not end until 40 years later. At the end of the nineteenth century dozens of different techniques were used to "sterilize" catgut, by immersing the cord in a cold chemical solution, by exposing it to steam, or by a combination of the two techniques, yet none of these approaches offered the ultimate solution. One of the many physicians working on the catgut problem at that time was the German surgeon Franz Kuhn (1866-1929), best known as a pioneer of intubation anesthesia. This review offers a brief biographical sketch of Kuhn's life and career on the occasion of the centenary of Sterile Catgut Kuhn. The goal of the present study is to describe several landmarks in the development of the catgut sterilization method. To explain this process, two approaches are taken: first, an analysis to see whether the character traits of the typical surgeon at that time provided the soil in which innovation could thrive, and second, an epistemological examination of the conceptual models for the attainment of knowledge current at that time. Perspectives for the future are explored in light of the "imperative of responsibility" of Hans Jonas.

  11. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

    PubMed Central

    Meliopoulos, Victoria A.; Andersen, Lauren E.; Birrer, Katherine F.; Simpson, Kaylene J.; Lowenthal, John W.; Bean, Andrew G. D.; Stambas, John; Stewart, Cameron R.; Tompkins, S. Mark; van Beusechem, Victor W.; Fraser, Iain; Mhlanga, Musa; Barichievy, Samantha; Smith, Queta; Leake, Devin; Karpilow, Jon; Buck, Amy; Jona, Ghil; Tripp, Ralph A.

    2012-01-01

    Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome-wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta-analysis of findings from genome-wide RNAi screens has shown influenza virus to be dependent on functional nodes in host cell pathways, requiring a wide variety of molecules and cellular proteins for replication. Because rapid evolution of the influenza A viruses persistently complicates the effectiveness of vaccines and therapeutics, a further understanding of the complex host cell pathways coopted by influenza virus for replication may provide new targets and strategies for antiviral therapy. RNAi genome screening technologies together with bioinformatics can provide the ability to rapidly identify specific host factors involved in resistance and susceptibility to influenza virus, allowing for novel disease intervention strategies.—Meliopoulos, V. A., Andersen, L. E., Birrer, K. F., Simpson, K. J., Lowenthal, J. W., Bean, A. G. D., Stambas, J., Stewart, C. R., Tompkins, S. M., van Beusechem, V. W., Fraser, I., Mhlanga, M., Barichievy, S., Smith, Q., Leake, D., Karpilow, J., Buck, A., Jona, G., Tripp, R. A. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. PMID:22247330

  12. Vacuum polarization corrections to low energy quark effective couplings

    NASA Astrophysics Data System (ADS)

    Paulo, Ademar; Braghin, Fabio L.

    2014-07-01

    In this work corrections to low energy punctual effective quark couplings up to the eighth order are calculated by considering vacuum polarization effects with the scalar quark-antiquark condensate. The departing point is a QCD-based Nambu-Jona-Lasinio model. By separating the quark field into two components, one that condenses and another one for interacting quarks, the former is integrated out with the help of usual auxiliary fields and an effective action in terms of interacting quark fields is found. The scalar auxiliary field reduces to the quark-antiquark condensate in the vacuum and the determinant is expanded in powers of the quark-antiquark bilinears generating chiral invariant effective 2N-quark interactions (N =2,3…). The corresponding coupling constants and effective masses are estimated, and the general trend is that for increasing the effective gluon mass the values of the effective coupling constants decrease. All the values are in good agreement with phenomenological fits.

  13. Spin-dependent structure functions in nuclear matter and the polarized EMC effect

    SciTech Connect

    I.C. Cloet; W. Bentz; A.W. Thomas

    2005-04-01

    An excellent description of both spin-independent and spin-dependent quark distributions and structure functions has been obtained with a modified Nambu-Jona-Lasinio model, which is free of unphysical thresholds for nucleon decay into quarks--hence incorporating an important aspect of confinement. We utilize this model to investigate nuclear medium modifications to structure functions, and find that we are readily able to reproduce both nuclear matter saturation and the experimental F{sub 2N}{sup A}/F{sub 2N} ratio, that is, the EMC effect. Applying this framework to determine g{sub 1p}{sup A}, we find that the ratio g{sub 1p}{sup A}/g{sub 1p} differs significantly from 1, with the quenching caused by the nuclear medium being about twice that of the spin-independent case. This represents an exciting result, which if confirmed experimentally, will reveal much about the quark structure of nuclear matter.

  14. Thermo-magnetic nonlocal NJL model in the real and imaginary time formalisms

    NASA Astrophysics Data System (ADS)

    Márquez, F.; Zamora, R.

    2017-02-01

    In this paper, we study a nonlocal Nambu-Jona-Lasinio (nNJL) model with a Gaussian regulator in presence of a uniform magnetic field. We take a mixed approach to the incorporation of temperature in the model, and consider aspects of both real and imaginary time formalisms. We include confinement in the model through the quasiparticle interpretation of the poles of the propagator. By working in the real time formalism and computing the spectral density function, we find that the effect of the magnetic field on the poles of the propagator can be entirely absorbed within the mean field value of the scalar field. The analytic structure of our propagator is then preserved in the weak magnetic field limit. The effect of the magnetic field in the deconfinement phase transition is then studied. It is found that, like with chiral symmetry restoration, magnetic catalysis occurs for the deconfinement phase transition. It is also found that the magnetic field enhances the thermodynamical instability of the system. We work in the weak field limit, i.e. (eB) < 5mπ2. At this level there is no splitting of the critical temperatures for chiral and deconfinement phase transitions.

  15. Pion and σ-meson Properties in a Strong Magnetic Field

    NASA Astrophysics Data System (ADS)

    Zhang, Rui; Fu, Wei-Jie; Liu, Yu-Xin

    2015-09-01

    With the Nambu-Jona-Lasinio (NJL) model we calculate the properties of pion and σ-meson at finite temperature and finite magnetic field. The obtained temperature and magnetic field strength dependence of the constituent quark mass M, the pion and σ-meson masses and the neutral pion decay constant indicates that, in the simple four fermion interaction model, there exists the magnetic catalysis effect. It also shows that the Gell-Mann-Oakes-Renner relation is violated obviously with the increasing of the temperature, and the effect of the magnetic field becomes pronounced only around the critical temperature. The deviation of the critical temperatures obtained with different criteria indicates that the chiral phase transition driven by the temperature in the magnetic field strength region we have considered is in fact a crossover. Supported by the National Natural Science Foundation of China under Grant Nos. 10935001, 11175004, and 11435001, and the National Key Basic Research Program of China under Grant Nos. G2013CB834400 and G2015CB856900

  16. Quark matter in a parallel electric and magnetic field background: Chiral phase transition and equilibration of chiral density

    NASA Astrophysics Data System (ADS)

    Ruggieri, M.; Peng, G. X.

    2016-05-01

    In this article, we study spontaneous chiral symmetry breaking for quark matter in the background of static and homogeneous parallel electric field E and magnetic field B . We use a Nambu-Jona-Lasinio model with a local kernel interaction to compute the relevant quantities to describe chiral symmetry breaking at a finite temperature for a wide range of E and B . We study the effect of this background on the inverse catalysis of chiral symmetry breaking for E and B of the same order of magnitude. We then focus on the effect of the equilibration of chiral density n5 , produced dynamically by an axial anomaly on the critical temperature. The equilibration of n5 , a consequence of chirality-flipping processes in the thermal bath, allows for the introduction of the chiral chemical potential μ5, which is computed self-consistently as a function of the temperature and field strength by coupling the number equation to the gap equation and solving the two within an expansion in E /T2 , B /T2 , and μ52/T2 . We find that even if chirality is produced and equilibrates within a relaxation time τM , it does not change drastically the thermodynamics, with particular reference to the inverse catalysis induced by the external fields, as long as the average μ5 at equilibrium is not too large.

  17. Phase diagram of QCD in a magnetic field

    NASA Astrophysics Data System (ADS)

    Andersen, Jens O.; Naylor, William R.; Tranberg, Anders

    2016-04-01

    Recent advances in our understanding of the phase structure and the phase transitions of hadronic matter in strong magnetic fields B and zero quark chemical potentials μf are reviewed in detail. Many aspects of QCD are described using low-energy effective theories and models such as the bag model, the hadron resonance gas model, chiral perturbation theory (χ PT ), the Nambu-Jona-Lasinio (NJL) model, the quark-meson (QM) model, and Polyakov-loop extended versions of the NJL and QM models. Their properties and applications are critically examined. This includes mean-field calculations as well as approaches beyond the mean-field approximation such as the functional renormalization group. Renormalization issues are discussed and the influence of the vacuum fluctuations on the chiral phase transition is pointed out. At T =0 , model calculations and lattice simulations predict magnetic catalysis: The quark condensate increases as a function of the magnetic field. This is covered in detail. Recent lattice results for the thermodynamics of non-Abelian gauge theories with emphasis on S U (2 )c and S U (3 )c are also discussed. In particular, inverse magnetic catalysis around the transition temperature Tc as a competition between contributions from valence quarks and sea quarks resulting in a decrease of Tc as a function of B is focused on. Finally, recent efforts to modify models in order to reproduce the behavior observed on the lattice are discussed.

  18. Studies of Wigner-Weyl solution and external magnetic field in an NJL model

    NASA Astrophysics Data System (ADS)

    Wang, Qing-Wu; Cui, Zhu-Fang; Zong, Hong-Shi

    2016-11-01

    In this paper, we explore the dynamical chiral symmetry breaking by employing a two-flavor Nambu-Jona-Lasinio (NJL) model with constant external magnetic field. After changing the coupling strength of the NJL model, we found that the Wigner-Weyl solution and Nambu-Goldstone solution of the gap equation could coexist. Even though the gap equation only has Nambu-Goldstone solution at zero temperature, the Wigner-Weyl solution may appear when magnetic field strength and temperature are nonzero. For the Nambu-Goldstone solution, magnetic field and temperature have opposite impact on the chiral dynamical mass. In the chiral limit, the magnetic field dependence of chiral dynamical mass reveals the existence of inverse magnetic catalysis for the Wigner-Weyl solution. However, the two phases have different responses to the magnetic field and temperature in the chiral limit but the same beyond chiral limit. Furthermore, the order of the transition from the Nambu-Goldstone phase to Wigner-Weyl phase depends on the choice of model parameters. We have also calculated the susceptibilities of dynamical mass with respect to the temperature.

  19. Chiral phase transition and Schwinger mechanism in a pure electric field

    NASA Astrophysics Data System (ADS)

    Cao, Gaoqing; Huang, Xu-Guang

    2016-01-01

    We systematically study the chiral symmetry breaking and restoration in the presence of a pure electric field in the Nambu-Jona-Lasinio model at finite temperature and baryon chemical potential. In addition, we also study the effect of the chiral phase transition on the charged pair production due to the Schwinger mechanism. For these purposes, a general formalism for parallel electric and magnetic fields is developed at finite temperature and chemical potential for the first time. In the pure electric field limit B →0 , we compute the order parameter, the transverse-to-longitudinal ratio of the Goldstone mode velocities, and the Schwinger pair production rate as functions of the electric field. The inverse catalysis effect of the electric field to chiral symmetry breaking is recovered. And the Goldstone mode is found to disperse anisotropically such that the transverse velocity is always smaller than the longitudinal one, especially at nonzero temperature and baryon chemical potential. As expected, the quark-pair production rate is greatly enhanced by the chiral symmetry restoration.

  20. What you don't know about vaccines can hurt you.

    PubMed

    Pace, Victor M

    2015-01-01

    As physicians, we've all learned in detail about the science behind vaccinations, but I suspect few of us have been taught about the history of vaccinations. Sure, we all know that Dr. Jonas Salk developed the poliovirus vaccine, but I wasn't aware that he inoculated himself, his wife, and his three children with his then experimental vaccine. When our editorial committee decided to focus on vaccinations as our theme for this month's Greene County Medical Society's Journal, I perused the internet for interesting topics. I came across a fascinating website, historyofvaccines.org; this website is a project of the College of Physicians of Philadelphia, touted as being the oldest professional medical organization in the United States. I credit the majority of the information in this article to the above website and the rest to the National Institutes of Health (nih.gov) website; I trust that the information is valid and true, based on the agencies behind these websites. Below are some interesting tidbits about vaccine preventable diseases that I found noteworthy to pass on to our readers.

  1. A cellular automaton model for microstructural simulation of friction stir welded AZ91 magnesium alloy

    NASA Astrophysics Data System (ADS)

    Akbari, Mostafa; Asadi, Parviz; Besharati Givi, MohammadKazem; Zolghadr, Parisa

    2016-03-01

    To predict the grain size and microstructure evolution during friction stir welding (FSW) of AZ91 magnesium alloy, a finite element model (FEM) is developed based on the combination of a cellular automaton model and the Kocks  -  Mecking and Laasraoui-Jonas models. First, according to the flow stress curves and using the Kocks  -  Mecking model, the hardening and recovery parameters and the strain rate sensitivity were calculated. Next, an FEM model was established in Deform-3D software to simulate the FSW of AZ91 magnesium alloy. The results of the FEM model are used in microstructure evolution models to predict the grain size and microstructure of the weld zone. There is a good agreement between the simulated and experimental microstructures, and the proposed model can simulate the dynamic recrystallization (DRX) process during FSW of AZ91 alloy. Moreover, microstructural properties of different points in the SZ as well as the effect of the w/v parameter on the grain size and microstructure are considered.

  2. The Use of Elasto-Visco-Plastic Material Model Coupled with Pressure-Volume Thermodynamic Relationship to Simulate the Stretch Blow Molding of Polyethylene Terephthalate

    NASA Astrophysics Data System (ADS)

    Mir, H.; Benrabah, Z.; Thibault, F.

    2007-05-01

    The use of polyethylene terephthalate (PET) in the stretch blow molding process presents several challenging issues due to various processing parameters and complex behavior of the material, which is both temperature and strain-rate dependent. In this paper, we generalize the G'Sell-Jonas law in 3D to model and simulate the elasto-visco-plastic (EVP) behavior of PET, taking into account strain-hardening and strain-softening. It is observed that the internal pressure (inside the preform) is significantly different from the nominal pressure (imposed in the blowing device upstream) since the internal pressure and the enclosed volume of the preform are fully coupled. In order to accurately simulate this phenomenon, a thermodynamic model was used to characterize the pressure-volume relationship (PVR). The predicted pressure evolution is thus more realistic when imposing only the machine power of the blowing device (air compressor or vacuum pump). Mechanical and temperature equilibrium equations are fully nonlinear and solved separately with implicit schemes on the current deformed configuration, which is updated at each time step. Biaxial characterization tests were used to determine the model parameters in order to simulate the stretch blow molding process using the pressure-volume thermodynamic relationship. To validate this model, thickness predictions for three industrial cases will be presented and compared to experimental measurements.

  3. Prospective Technology Assessment of Synthetic Biology: Fundamental and Propaedeutic Reflections in Order to Enable an Early Assessment.

    PubMed

    Schmidt, Jan Cornelius

    2016-08-01

    Synthetic biology is regarded as one of the key technosciences of the future. The goal of this paper is to present some fundamental considerations to enable procedures of a technology assessment (TA) of synthetic biology. To accomplish such an early "upstream" assessment of a not yet fully developed technology, a special type of TA will be considered: Prospective TA (ProTA). At the center of ProTA are the analysis and the framing of "synthetic biology," including a characterization and assessment of the technological core. The thesis is that if there is any differentia specifica giving substance to the umbrella term "synthetic biology," it is the idea of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called "late-modern technology." -I start this paper by analyzing the three most common visions of synthetic biology. Then I argue that one particular vision deserves more attention because it underlies the others: the vision of self-organization. I discuss the inherent limits of this new type of late-modern technology in the attempt to control and monitor possible risk issues. I refer to Hans Jonas' ethics and his early anticipation of the risks of a novel type of technology. I end by drawing conclusions for the approach of ProTA towards an early societal shaping of synthetic biology.

  4. Vector Interaction Enhanced Bag Model for Astrophysical Applications

    NASA Astrophysics Data System (ADS)

    Klähn, Thomas; Fischer, Tobias

    2015-09-01

    For quark matter studies in astrophysics the thermodynamic bag model (tdBAG) has been widely used. Despite its success it fails to account for various phenomena expected from QCD. We suggest a straightforward extension of tdBAG in order to take the dynamical breaking of chiral symmetry and the influence of vector interactions explicitly into account. As for tdBAG the model mimics confinement in a phenomenological approach. It is based on an analysis of the Nambu-Jona-Lasinio (NJL) model at finite density. Furthermore, we demonstrate how NJL and bag models in this regime follow from the more general and QCD-based framework of the Dyson-Schwinger equations in a medium by assuming simple gluon contact interaction. Based on our simple and novel model, we construct quark hadron hybrid equations of state and systematically study chiral and deconfinement phase transitions, the appearance of s-quarks, and the role of vector interaction. We further study these aspects for matter in β-equilibrium at zero temperature, with particular focus on the current ˜2 {M}⊙ maximum mass constraint for neutron stars. Our approach indicates that the currently only theoretical evidence for the hypothesis of stable strange matter is an artifact of tdBAG and results from neglecting the dynamical breaking of chiral symmetry.

  5. Probing the hadron-quark mixed phase at high isospin and baryon density. Sensitive observables

    NASA Astrophysics Data System (ADS)

    Di Toro, Massimo; Colonna, Maria; Greco, Vincenzo; Shao, Guo-Yun

    2016-08-01

    We discuss the isospin effect on the possible phase transition from hadronic to quark matter at high baryon density and finite temperatures. The two-Equation of State (Two-EoS) model is adopted to describe the hadron-quark phase transition in dense matter formed in heavy-ion collisions. For the hadron sector we use Relativistic Mean-Field (RMF) effective models, already tested on heavy-ion collision (HIC). For the quark phase we consider various effective models, the MIT-Bag static picture, the Nambu-Jona-Lasinio (NJL) approach with chiral dynamics and finally the NJL coupled to the Polyakov-loop field (PNJL), which includes both chiral and (de)confinement dynamics. The idea is to extract mixed phase properties which appear robust with respect to the model differences. In particular we focus on the phase transitions of isospin asymmetric matter, with two main results: i) an earlier transition to a mixed hadron-quark phase, at lower baryon density/chemical potential with respect to symmetric matter; ii) an "Isospin Distillation" to the quark component of the mixed phase, with predicted effects on the final hadron production. Possible observation signals are suggested to probe in heavy-ion collision experiments at intermediate energies, in the range of the NICA program.

  6. Hadron-quark phase transition in asymmetric matter with dynamical quark masses

    SciTech Connect

    Shao, G. Y.; Colonna, M.; Di Toro, M.; Greco, V.; Plumari, S.; Liu, B.; Liu, Y. X.

    2011-05-01

    The two-equation-of-state model is used to describe the hadron-quark phase transition in asymmetric matter formed at high density in heavy-ion collisions. For the quark phase, the three-flavor Nambu-Jona-Lasinio effective theory is used to investigate the influence of dynamical quark mass effects on the phase transition. At variance to the MIT-Bag results, with fixed-current quark masses, the main important effect of the chiral dynamics is the appearance of an end point for the coexistence zone. We show that a first-order hadron-quark phase transition may take place in the region T subset of (50-80) MeV and {rho}{sub B} subset of (2-4){rho}{sub 0}, which is possible to be probed in the new planned facilities, such as FAIR at GSI-Darmstadt and NICA at JINR-Dubna. From the isospin properties of the mixed phase, some possible signals are suggested. The importance of chiral symmetry and dynamical quark mass on the hadron-quark phase transition is stressed. The difficulty of an exact location of a critical end point comes from its appearance in a region of competition between chiral symmetry breaking and confinement, where our knowledge of effective QCD theories is still rather uncertain.

  7. Strange quark matter in the presence of explicit symmetry breaking interactions

    NASA Astrophysics Data System (ADS)

    Moreira, J.; Morais, J.; Hiller, B.; Osipov, A. A.; Blin, A. H.

    2015-06-01

    It is shown that a first-order transition associated with a jump in the strange-quark mass appears in a generalized three-flavor Nambu-Jona-Lasinio treatment of quark matter. The generalization of the Lagrangian displays the complete set of spin-0 interactions at leading and subleading orders (LO and NLO) in 1/Nc counting, including the recently derived NLO explicit chiral symmetry breaking interactions which are of the same order as the 't Hooft flavor determinant. The parameters of the model are tightly constrained by the low-energy characteristics in both the pseudoscalar and scalar meson sectors. The transition occurs in a moderate chemical potential region (μ ≃400 MeV for zero temperature) in addition to the usual chiral transition associated with the light-quark sector. This feature has at its root the inclusion of the explicit chiral symmetry breaking interactions, which therefore can be seen to act as a catalyst in the production of strange-quark matter when compared to the conventional version of the model that takes only into account the 't Hooft interaction in the NLO. It can be traced back to the effect of the interactions which do not violate the Okubo-Zweig-Iizuka rule, without which the empirical ordering of the scalars (mK⋆

  8. Ab initio calculations of the thermodynamics and phase diagram of zirconium

    NASA Astrophysics Data System (ADS)

    Hao, Yan-Jun; Zhang, Lin; Chen, Xiang-Rong; Cai, Ling-Cang; Wu, Qiang; Alfè, Dario

    2008-10-01

    The finite-temperature density-functional theory and quasiharmonic lattice dynamics are used to calculate the Gibbs free energy and quasiharmonic phonons of the hexagonal-close-packed (hcp) and omega (ω) crystal structures for Zr. The hcp phonon dispersions agree with experiment; the ω phonon dispersions have not been measured yet. From the free energy, the volume thermal expansion coefficients of α-Zr are predicted. The calculated volume thermal expansion coefficients for α-Zr are in good agreement with the experiment data at T>100K . Our calculated results found that at zero-temperature the lowest-energy phase is not the ω but the hcp phase. This conclusion is in accordance with the result of Schnell and Albers, but in disagreement with those of Ahuja and Jona and Marcus. The predicted phase boundary of α→ω is in good agreement with the available experiment; however, other theoretical results are far from the experiment at high temperatures.

  9. Constitutive modeling of polycarbonate over a wide range of strain rates and temperatures

    NASA Astrophysics Data System (ADS)

    Wang, Haitao; Zhou, Huamin; Huang, Zhigao; Zhang, Yun; Zhao, Xiaoxuan

    2017-02-01

    The mechanical behavior of polycarbonate was experimentally investigated over a wide range of strain rates (10^{-4} to 5× 103 s^{-1}) and temperatures (293 to 353 K). Compression tests under these conditions were performed using a SHIMADZU universal testing machine and a split Hopkinson pressure bar. Falling weight impact testing was carried out on an Instron Dynatup 9200 drop tower system. The rate- and temperature-dependent deformation behavior of polycarbonate was discussed in detail. Dynamic mechanical analysis (DMA) tests were utilized to observe the glass (α ) transition and the secondary (β ) transition of polycarbonate. The DMA results indicate that the α and β transitions have a dramatic influence on the mechanical behavior of polycarbonate. The decompose/shift/reconstruct (DSR) method was utilized to decompose the storage modulus into the α and β components and extrapolate the entire modulus, the α-component modulus and the β-component modulus. Based on three previous models, namely, Mulliken-Boyce, G'Sell-Jonas and DSGZ, an adiabatic model is proposed to predict the mechanical behavior of polycarbonate. The model considers the contributions of both the α and β transitions to the mechanical behavior, and it has been implemented in ABAQUS/Explicit through a user material subroutine VUMAT. The model predictions are proven to essentially coincide with the experimental results during compression testing and falling weight impact testing.

  10. Derivation of Transport Equations for a Strongly Interacting Lagrangian in Powers of ħand 1/ Nc

    NASA Astrophysics Data System (ADS)

    Klevansky, S. P.; Ogura, A.; Hüfner, J.

    1997-11-01

    Transport theory for an interacting fermionic system is reviewed and applied to the chiral Lagrangian of the Nambu-Jona-Lasinio model. Two expansions must be applied: an expansion in the inverse number of colors, 1/Nc, due to the nature of the strong coupling theory, and a semiclassical expansion, in powers of ħ. The quasiparticle approximation is implemented at an early stage, and spin effects are omitted. The self-energy is evaluated, self-consistently only in the Hartree approximation, and semi-perturbatively in the collision integral. In the Hartree approximation,O((1/Nc)0), the Vlasov equation is recovered toO(ħ1), together with an on-mass shell constraint equation, that is automatically fulfilled by the quasiparticle ansatz. The expressions for the self-energy to orderO((1/Nc)) lead to the collision term. Here one sees explicitly that particle-antiparticle creation and annihilation processes are suppressed that would otherwise be present, should an off-shell energy spectral function be admitted. A clear identification of thes,tanduchannel scattering processes in connection with the self-energy graphs is made and the origin of the mixed terms is made evident. Finally, after ordering according to powers in ħ, a Boltzmann-like form for the collision integral is obtained.

  11. Effect of temperature and magnetic field on two-flavor superconducting quark matter

    NASA Astrophysics Data System (ADS)

    Mandal, Tanumoy; Jaikumar, Prashanth

    2016-10-01

    We investigate the effect of turning on temperature for the charge neutral phase of two-flavor color superconducting (2SC) dense quark matter in the presence of constant external magnetic field. Within the Nambu-Jona-Lasinio model, by tuning the diquark coupling strength, we study the interdependent evolution of the quark Bardeen-Cooper-Schrieffer gap and dynamical mass as functions of temperature and magnetic field. We find that magnetic field B ≳0.02 GeV2 (1 018 G ) leads to anomalous temperature behavior of the gap in the gapless 2SC phase (moderately strong coupling), reminiscent of previous results in the literature found in the limit of weak coupling without magnetic field. The 2SC gap in the strong coupling regime is abruptly quenched at ultrahigh magnetic field due to the mismatched Fermi surfaces of up and down quarks imposed by charge neutrality and oscillation of the gap due to Landau level quantization. The dynamical quark mass also displays strong oscillation and magnetic catalysis at high magnetic field, although the latter effect is tempered by nonzero temperature. We discuss the implications for newly born compact stars with superconducting quark cores.

  12. Chiral nucleon-Δ using the coherent-pion pair approximation

    NASA Astrophysics Data System (ADS)

    Sayed Aly, Tarek; McNeil, J. A.

    1996-10-01

    Despite significant strides in the numerical assault on QCD, this candidate theory of the strong interactions remains a computational challenge and models incorporating its important symmetries remain attractive alternatives for gaining insight into the nucleon problem. One such class of models which does not incorporate confinement but does respect chiral symmetry is the Nambu-Jona-Lasinio model and in particular its bosonized variant, the linear sigma model using quarks and mesonic degrees of freedom. About a decade ago several groups made significant progress in understanding fundamental nucleon properties using such models. In this work we re-visit one such effort undertaken by K. Goeke et al.(K. Goeke, M. Harvey, F. Grümmer, and J. N. Urbano, Phys. Rev. D37), 754 (1988). who computed nucleon and Δ properties using the so-called coherent pair approximation to treat the quantum nature of the pion field in a more realistic fashion. In rederiving their equations we have discovered some discrepancies in the treatment of the coherent pair Fock states. In this work we present alternative equations for the coherent-pair states. Numerical work to evaluate the new equations for the nucleon-Δ sector are underway.

  13. Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression

    PubMed Central

    Romas, Laura; Birse, Kenzie; Mayer, Kenneth H.; Abou, Max; Westmacott, Garrett; Giguere, Rebecca; Febo, Irma; Cranston, Ross D.; Carballo-Diéguez, Alex; McGowan, Ian

    2016-01-01

    Abstract Rectal use of a 1% tenofovir (TFV) gel is currently being evaluated for HIV prevention. While careful assessment of mucosal safety of candidate microbicides is a primary concern, tools to assess mucosal toxicity are limited. Mass spectrometry-based proteomics is a sensitive and high-throughput technique that can provide in-depth information on inflammation processes in biological systems. In this study, we utilized a proteomics approach to characterize mucosal responses in study participants involved in a phase 1 clinical trial of a rectal TFV-based gel. Project Gel was a phase 1 randomized (1:1), double-blind, multisite, placebo-controlled trial in which 24 participants received rectal TFV or a universal placebo [hydroxyethyl cellulose (HEC)] over a course of 8 daily doses. Rectal mucosal swabs were collected after 0, 1, and 8 doses and were analyzed by label-free tandem mass spectrometry. Differential protein expression was evaluated using a combination of paired (time-effects) and unpaired (across study arm) t-tests, and multivariate [least absolute shrinkage and selection operator (LASSO)] modeling. Within the TFV arm, 7% (17/249, p < .05) and 10% (25/249, p < .05) of total proteins changed after 1 and 8 daily applications of TFV gel, respectively, compared to 3% (7/249, p < .05) and 6% (16/249, p < .05) in the HEC arm. Biofunctional analysis associated TFV use with a decrease in epidermal barrier proteins (adj. p = 1.21 × 10−10). Multivariate modeling identified 13 proteins that confidently separated TFV gel users (100% calibration and 96% cross-validation accuracy), including the epithelial integrity factors (FLMNB, CRNN, CALM), serpins (SPB13, SPB5), and cytoskeletal proteins (VILI, VIME, WRD1). This study suggested that daily rectal applications of a 1% TFV gel may be associated with mucosal proteome changes involving epidermal development. Further assessment of more extended use of TFV-gel is recommended to validate

  14. Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia

    PubMed Central

    Nagy, Béla; Jin, Jianguo; Ashby, Barrie; Reilly, Michael P.; Kunapuli, Satya P.

    2011-01-01

    Summary Background In hypercholesterolemia, platelets demonstrate increased reactivity and promote the development of cardiovascular disease. Objective This study was carried out to investigate the contribution of the ADP receptor P2Y12-mediated pathway in platelet hyperreactivity due to hypercholesterolemia. Methods Low-density lipoprotein receptor deficient mice and C57Bl/6 wild type mice were fed on normal chow and high-fat (Western or Paigen) diets for 8 weeks to generate differently elevated cholesterol levels. P2Y12 receptor induced functional responses via Gi signaling were studied ex vivo when washed murine platelets were activated by 2MeSADP and PAR4 agonist AYPGKF in the presence and absence of indomethacin. Platelet aggregation, secretion, αIIbβ3 receptor activation and the phosphorylation of extracellular signal-regulated protein kinase (ERK) and Akt were analyzed. Results Plasma cholesterol levels ranged from 69±10 to 1011±185 mg/dl depending on diet in mice with different genotypes. Agonist-dependent aggregation, dense and α-granule secretion and JON/A binding were gradually and significantly (P < 0.05) augmented at low agonist concentration in correlation with the increasing plasma cholesterol levels even if elevated thromboxane generation was blocked. These functional responses were induced via increased level of Gi mediated ERK and Akt phosphorylation in hypercholesterolemic mice versus normocholesterolemic animals. In addition, blocking of the P2Y12 receptor by AR-C69931MX (Cangrelor) resulted in strongly reduced platelet aggregation in mice with elevated cholesterol levels compared to normocholesterolemic controls. Conclusions These data revealed that the P2Y12 receptor pathway was substantially involved in platelet hyperreactivity associated with mild and severe hypercholesterolemia. PMID:21261805

  15. Effective field theories of baryons and mesons, or, what do quarks do?

    SciTech Connect

    Keaton, G.L.

    1995-06-26

    This thesis is an attempt to understand the properties of the protons, pions and other hadrons in terms of their fundamental building blocks. In the first chapter the author reviews several of the approaches that have already been developed. The Nambu-Jona-Lasinio model offers the classic example of a derivation of meson properties from a quark Lagrangian. The chiral quark model encodes much of the intuition acquired in recent decades. The author also discusses the non-linear sigma model, the Skyrme model, and the constituent quark model, which is one of the oldest and most successful models. In the constituent quark model, the constituent quark appears to be different from the current quark that appears in the fundamental QCD Lagrangian. Recently it was proposed that the constituent quark is a topological soliton. In chapter 2 the author investigates this soliton, calculating its mass, radius, magnetic moment, color magnetic moment, and spin structure function. Within the approximations used, the magnetic moments and spin structure function cannot simultaneously be made to agree with the constituent quark model. In chapter 3 the author uses a different plan of attack. Rather than trying to model the constituents of the baryon, he begins with an effective field theory of baryons and mesons, with couplings and masses that are simply determined phenomenologically. Meson loop corrections to baryon axial currents are then computed in the 1/N expansion. It is already known that the one-loop corrections are suppressed by a factor 1/N; here it is shown that the two-loop corrections are suppressed by 1/N{sup 2}. To leading order, these corrections are exactly the same as would be calculated in the constituent quark model. This method therefore offers a different approach to the constituent quark.

  16. Biomolecular simulation on thousands of processors

    NASA Astrophysics Data System (ADS)

    Phillips, James Christopher

    Classical molecular dynamics simulation is a generally applicable method for the study of biomolecular aggregates of proteins, lipids, and nucleic acids. As experimental techniques have revealed the structures of larger and more complex biomolecular machines, the time required to complete even a single meaningful simulation of such systems has become prohibitive. We have developed the program NAMD to simulate systems of 50,000--500,000 atoms efficiently with full electrostatics on parallel computers with 1000 and more processors. NAMD's scalability is achieved through latency tolerant adaptive message-driven execution and measurement-based load balancing. NAMD is implemented in C++ and uses object-oriented design and threads to shield the basic algorithms from the necessary complexity of high-performance parallel execution. Apolipoprotein A-I is the primary protein constituent of high density lipoprotein particles, which transport cholesterol in the bloodstream. In collaboration with A. Jonas, we have constructed and simulated models of the nascent discoidal form of these particles, providing theoretical insight to the debate regarding the lipid-bound structure of the protein. Recently, S. Sligar and coworkers have created 10 nm phospholipid bilayer nanoparticles comprising a small lipid bilayer disk solubilized by synthetic membrane scaffold proteins derived from apolipoprotein A-I. Membrane proteins may be embedded in the water-soluble disks, with various medical and technological applications. We are working to develop variant scaffold proteins that produce disks of greater size, stability, and homogeneity. Our simulations have demonstrated a significant deviation from idealized cylindrical structure, and are being used in the interpretation of small angle x-ray scattering data.

  17. Single-flavor CSL phase in compact stars

    SciTech Connect

    Blaschke, David; Sandin, Fredrik; Klaehn, Thomas; Berdermann, Jens

    2008-08-29

    We suggest a scenario where the three light quark flavors are sequentially deconfined under increasing pressure in cold asymmetric nuclear matter as, e.g., in neutron stars. The basis for our analysis is a chiral quark matter model of Nambu-Jona-Lasinio (NJL) type with diquark pairing in the spin-1 single flavor (CSL), spin-0 two flavor (2SC) and three flavor (CFL) channels. We find that nucleon dissociation sets in at about the saturation density, n{sub 0}, when the down-quark Fermi sea is populated (d-quark dripline) due to the flavor asymmetry induced by {beta}-equilibrium and charge neutrality. At about 3n{sub 0} u-quarks appear and a two-flavor color superconducting (2SC) phase is formed. The s-quark Fermi sea is populated only at still higher baryon density, when the quark chemical potential is of the order of the dynamically generated strange quark mass. We construct two different hybrid equations of state (EoS) using the Dirac-Brueckner Hartree-Fock (DBHF) approach and the EoS by Shen et al. in the nuclear matter sector. The corresponding hybrid star sequences have maximum masses of, respectively, 2.1 and 2.0 M{sub {center_dot}}. Two- and three-flavor quark-matter phases exist only in gravitationally unstable hybrid star solutions in the DBHF case, while the Shen-based EoS produce stable configurations with a 2SC phase component in the core of massive stars. Nucleon dissociation due to d-quark drip at the crust-core boundary fulfills basic criteria for a deep crustal heating process which is required to explain superbusts as well as cooling of X-ray transients.

  18. Phase diagram of three-flavor quark matter under compact star constraints

    SciTech Connect

    Blaschke, D.; Fredriksson, S.; Sandin, F.; Grigorian, H.; Oeztas, A.M.

    2005-09-15

    The phase diagram of three-flavor quark matter under compact star constraints is investigated within a Nambu-Jona-Lasinio model. Global color and electric charge neutrality is imposed for {beta}-equilibrated superconducting quark matter. The constituent quark masses and the diquark condensates are determined self-consistently in the plane of temperature and quark chemical potential. Both strong and intermediate diquark coupling strengths are considered. We show that in both cases, gapless superconducting phases do not occur at temperatures relevant for compact star evolution, i.e., below T{approx}50 MeV. The stability and structure of isothermal quark star configurations are evaluated. For intermediate coupling, quark stars are composed of a mixed phase of normal (NQ) and two-flavor superconducting (2SC) quark matter up to a maximum mass of 1.21 M{sub {center_dot}}. At higher central densities, a phase transition to the three-flavor color flavor locked (CFL) phase occurs and the configurations become unstable. For the strong diquark coupling we find stable stars in the 2SC phase, with masses up to 1.33 M{sub {center_dot}}. A second family of more compact configurations (twins) with a CFL quark matter core and a 2SC shell is also found to be stable. The twins have masses in the range 1.30...1.33 M{sub {center_dot}}. We consider also hot isothermal configurations at temperature T=40 MeV. When the hot maximum mass configuration cools down, due to emission of photons and neutrinos, a mass defect of 0.1 M{sub {center_dot}} occurs and two final state configurations are possible.

  19. U{sub A}(1) anomaly in hot and dense QCD and the critical surface

    SciTech Connect

    Chen, J.-W.; Fukushima, Kenji; Kohyama, Hiroaki; Ohnishi, Kazuaki; Raha, Udit

    2009-09-01

    We discuss the chiral phase transition in hot and dense QCD with three light flavors. Inspired by the well-known fact that the U{sub A}(1) anomaly could induce first order phase transitions, we study the effect of the possible restoration of the U{sub A}(1) symmetry at finite density. In particular, we explore the link between the U{sub A}(1) restoration and the recent lattice QCD results of de Forcrand and Philipsen, in which the first order phase transition region near zero chemical potential ({mu}) shrinks in the quark mass and {mu} space when {mu} is increased. Starting from the Ginzburg-Landau theory for general discussions, we then use the Nambu-Jona-Lasinio model for quantitative studies. With the partial U{sub A}(1) restoration modeled by the density dependent 't Hooft interaction, we fit the shrinking of the first order region found in de Forcrand and Philipsen's lattice calculation at low {mu}. At higher {mu}, the first order region might shrink or expand, depending on the scenarios. This raises the possibility that despite the shrinking of the first order region at lower {mu}, the QCD critical end point might still exist due to the expansion at higher {mu}. In this case, very high precision lattice data will be needed to detect the recently observed backbending of the critical surface with the currently available analytic continuation or Taylor expansion approaches. Lattice computations could, however, test whether the U{sub A}(1) restoration is responsible for the shrinking of the first order region by computing the {eta}{sup '} mass or the topological susceptibility at small {mu}.

  20. Properties of mesons in a strong magnetic field.

    PubMed

    Zhang, Rui; Fu, Wei-Jie; Liu, Yu-Xin

    By extending the [Formula: see text]-derivable approach in the Nambu-Jona-Lasinio model to a finite magnetic field we calculate the properties of pion, [Formula: see text], and [Formula: see text] mesons in a magnetic field at finite temperature not only in the quark-antiquark bound state scheme but also in the pion-pion scattering resonant state scenario. Our calculation as a result makes manifest that the masses of [Formula: see text] and [Formula: see text] meson can be nearly degenerate at the pseudo-critical temperature which increases with increasing magnetic field strength, and the [Formula: see text] mass ascends suddenly at almost the same critical temperature. Meanwhile the [Formula: see text] mesons' masses decrease with the temperature but increase with the magnetic field strength. We also check the Gell-Mann-Oakes-Renner relation and find that the relation can be violated clearly with increasing temperature, and the effect of the magnetic field becomes pronounced around the critical temperature. With different criteria, we analyze the effect of the magnetic field on the chiral phase transition and find that the pseudo-critical temperature of the chiral phase cross, [Formula: see text], is always enhanced by the magnetic field. Moreover, our calculations indicate that the [Formula: see text] mesons will get melted as the chiral symmetry has not yet been restored, but the [Formula: see text] meson does not disassociate even at very high temperature. Particularly, it is the first to show that there does not exist a vector meson condensate in the QCD vacuum in the pion-pion scattering scheme.

  1. Tools for Studying Electron and Spin Transport in Single Molecules

    NASA Astrophysics Data System (ADS)

    Ralph, Daniel C.

    2005-03-01

    Experiments in the field of single-molecule electronics are challenging in part because it can be very difficult to control and characterize the device structure. Molecules contacted by metal electrodes cannot easily be imaged by microscopy techniques. Moreover, if one attempts to characterize the device structure simply by measuring a current-voltage curve, it is easy to mistake nonlinear transport across a bare tunnel junction or a metallic short for a molecular signal. I will discuss the development of a set of experimental test structures that enable the properties of a molecular device to be tuned controllably in-situ, so that the transport mechanisms can be studied more systematically and compared with theoretical predictions. My collaborators and I are developing the means to use several different types of such experimental "knobs" in coordination: electrostatic gating to shift the energy levels in a molecule, mechanical motion to adjust the molecular configuration or the molecule-electrode coupling strength, illumination with light to promote electrons to excited states or to make and break chemical bonds, and the use of ferromagnetic electrodes to study spin-polarized transport. Our work so far has provided new insights into Kondo physics, the coupling between a molecule's electronic and mechanical degrees of freedom, and spin transport through a molecule between magnetic electrodes. Collaborators: Radek Bialczak, Alex Champagne, Luke Donev, Jonas Goldsmith, Jacob Grose, Janice Guikema, Jiwoong Park, Josh Parks, Abhay Pasupathy, Jason Petta, Sara Slater, Burak Ulgut, Alexander Soldatov, H'ector Abruña, and Paul McEuen.

  2. Sleep Disordered Breathing During Live High-Train Low in Normobaric Versus Hypobaric Hypoxia.

    PubMed

    Saugy, Jonas J; Schmitt, Laurent; Fallet, Sibylle; Faiss, Raphael; Vesin, Jean-Marc; Bertschi, Mattia; Heinzer, Raphaël; Millet, Grégoire P

    2016-09-01

    Saugy, Jonas J., Laurent Schmitt, Sibylle Fallet, Raphael Faiss, Jean-Marc Vesin, Mattia Bertschi, Raphaël Heinzer, and Grégoire P. Millet. Sleep disordered breathing during live high-train low in normobaric versus hypobaric hypoxia. High Alt Med Biol. 17:233-238, 2016.-The present study aimed to compare sleep disordered breathing during live high-train low (LHTL) altitude camp using normobaric hypoxia (NH) and hypobaric hypoxia (HH). Sixteen highly trained triathletes completed two 18-day LHTL camps in a crossover designed study. They trained at 1100-1200 m while they slept either in NH at a simulated altitude of 2250 m or in HH. Breathing frequency and oxygen saturation (SpO2) were recorded continuously during all nights and oxygen desaturation index (ODI 3%) calculated. Breathing frequency was lower for NH than HH during the camps (14.6 ± 3.1 breath × min(-1) vs. 17.2 ± 3.4 breath × min(-1), p < 0.001). SpO2 was lower for HH than NH (90.8 ± 0.3 vs. 91.9 ± 0.2, p < 0.001) and ODI 3% was higher for HH than NH (15.1 ± 3.5 vs. 9.9 ± 1.6, p < 0.001). Sleep in moderate HH is more altered than in NH during a LHTL camp.

  3. CEACAM1 regulates integrin αIIbβ3-mediated functions in platelets.

    PubMed

    Yip, Jana; Alshahrani, Musaed; Beauchemin, Nicole; Jackson, Denise E

    2016-01-01

    Previous studies have implicated that the Ig-ITIM superfamily member, CEACAM1 may regulate integrin function. While CEACAM1 has been demonstrated to play a role as an inhibitory co-receptor of ITAM-associated GPVI/FcR γ-chain signaling pathways in platelets, its physiologic role in integrin αIIbβ3-mediated platelet function is unclear. In this study, we investigate the functional importance of Ceacam1 in murine platelets. We show that CEACAM1 is constitutively associated with integrin αIIbβ3 in resting human and mouse platelets as demonstrated by co-immunoprecipitation studies. Using Ceacam1-deficient mice, we show that they have prolonged tail bleeding times and volume of blood lost that is corrected by reconstitution with platelet Ceacam1. Ceacam1(-/-) platelets have moderate integrin αIIbβ3 mediated functional defects with impaired kinetics of platelet spreading on fibrinogen and failure to retract fibrin clots in vitro. This functional integrin αIIbβ3 defect could not be attributed to altered integrin αIIbβ3 expression. Ceacam1(-/-) platelets displayed normal "inside-out" signaling properties as demonstrated by normal agonist-induced binding of soluble (fluorescein isothiocyanate) FITC-fibrinogen, JON/A antibody binding, and increases in cytosolic free calcium levels. This study provides direct evidence that Ceacam1 is essential for normal integrin αIIbβ3-mediated platelet function and that disruption of mouse Ceacam1 induced moderate integrin αIIbβ3-mediated functional defects.

  4. Chiral quark dynamics and topological charge: The role of the Ramond-Ramond U(1) gauge field in holographic QCD

    NASA Astrophysics Data System (ADS)

    Thacker, H. B.; Xiong, Chi; Kamat, Ajinkya S.

    2011-11-01

    The Witten-Sakai-Sugimoto construction of holographic QCD in terms of D4 color branes and D8 flavor branes in type IIA string theory is used to investigate the role of topological charge in the chiral dynamics of quarks in QCD. The QCD theta term arises from a compactified five-dimensional Chern-Simons term on the D4 branes. This term couples the QCD topological charge to the Ramond-Ramond (RR) U(1) gauge field of type IIA string theory. For large Nc the contribution of instantons (D0 branes) is suppressed, and the nonzero topological susceptibility of pure-glue QCD is attributed to the presence of D6 branes, which constitute magnetic sources of the RR gauge field. The topological charge of QCD is required, by an anomaly inflow argument, to coincide in space-time with the intersection of the D6 branes and the D4 color branes. This clarifies the relation between D6 branes and the coherent, codimension-one topological charge membranes observed in QCD Monte Carlo calculations. Using open-string/closed-string duality, we interpret a quark loop (represented by a D4-D8 open-string loop) in terms of closed-string exchange between color and flavor branes. The role of the RR gauge field in quark-antiquark annihilation processes is discussed. RR exchange in the s-channel generates a 4-quark contact term which produces an η' mass insertion and provides an explanation for the observed spin-parity structure of the Okubo-Zweig-Iizuka rule. The (log⁡DetU)2 form of the U(1) anomaly emerges naturally. RR exchange in the t-channel of the qq¯ scattering amplitude produces a Nambu-Jona-Lasinio interaction which may provide a mechanism for spontaneous breaking of SU(Nf)×SU(Nf).

  5. Full sky study of diffuse Galactic emission at decimeter wavelengths

    NASA Astrophysics Data System (ADS)

    Platania, P.; Burigana, C.; Maino, D.; Caserini, E.; Bersanelli, M.; Cappellini, B.; Mennella, A.

    2003-11-01

    A detailed knowledge of the Galactic radio continuum is of high interest for studies of the dynamics and structure of the Galaxy as well as for the problem of foreground removal in Cosmic Microwave Background measurements. In this work we present a full-sky study of the diffuse Galactic emission at frequencies of few GHz, where synchrotron radiation is by far the dominant component. We perform a detailed combined analysis of the extended surveys at 408, 1420 and 2326 MHz (by Haslam et al. 1982; Reich 1982; Reich & Reich 1986; Jonas et al. 1998, respectively). Using the technique applied by Schlegel et al. (1998) to the IRAS data, we produce destriped versions of the three maps. This allows us to construct a nearly-full-sky map of the spectral index and of the normalization factor with sub-degree angular resolution. The resulting distribution of the spectral indices has an average of bar beta = 2.695 and dispersion sigma beta = 0.120. This is representative for the Galactic diffuse synchrotron emission, with only minor effects from free-free emission and point sources. The maps produced in this work are available via ftp at cdsarc.u-strasbg.fr The maps produced in this work are only available in electronic form via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg/cgi-bin/qcat?J/A+A/410/847 Colour figures are only available in the electronic edition of this paper via http://www.edpsciences.org

  6. A Flea on Schrödinger's Cat

    NASA Astrophysics Data System (ADS)

    Landsman, N. P. (Klaas); Reuvers, Robin

    2013-03-01

    We propose a technical reformulation of the measurement problem of quantum mechanics, which is based on the postulate that the final state of a measurement is classical; this accords with experimental practice as well as with Bohr's views. Unlike the usual formulation (in which the post-measurement state is a unit vector in Hilbert space), our version actually opens the possibility of admitting a purely technical solution within the confines of conventional quantum theory (as opposed to solutions that either modify this theory, or introduce unusual and controversial interpretative rules and/or ontologies). To that effect, we recall a remarkable phenomenon in the theory of Schrödinger operators (discovered in 1981 by Jona-Lasinio, Martinelli, and Scoppola), according to which the ground state of a symmetric double-well Hamiltonian (which is paradigmatically of Schrödinger's Cat type) becomes exponentially sensitive to tiny perturbations of the potential as ħ→0. We show that this instability emerges also from the textbook wkb approximation, extend it to time-dependent perturbations, and study the dynamical transition from the ground state of the double well to the perturbed ground state (in which the cat is typically either dead or alive, depending on the details of the perturbation). Numerical simulations show that adiabatically arising perturbations may (quite literally) cause the collapse of the wave-function in the classical limit. Thus, at least in the context of a simple mathematical model, we combine the technical and conceptual virtues of decoherence (which fails to solve the measurement problem but launches the key idea that perturbations may come from the environment) with those of dynamical collapse models à la grw (which do solve the measurement problem but are ad hoc), without sharing their drawbacks: single measurement outcomes are obtained (instead of merely diagonal reduced density matrices), and no modification of quantum mechanics is needed.

  7. On the Nambu fermion-boson relations for superfluid 3He

    NASA Astrophysics Data System (ADS)

    Sauls, J. A.; Mizushima, Takeshi

    2017-03-01

    Superfluid 3He is a spin-triplet (S =1 ), p -wave (L =1 ) BCS condensate of Cooper pairs with total angular momentum J =0 in the ground state. In addition to the breaking of U(1) gauge symmetry, separate spin or orbital rotation symmetry is broken to the maximal subgroup SO (3) S×SO (3) L→SO(3 ) J . The fermions acquire mass mF≡Δ , where Δ is the BCS gap. There are also 18 bosonic excitations: 4 Nambu-Goldstone modes and 14 massive amplitude Higgs modes. The bosonic modes are labeled by the total angular momentum J ∈{0 ,1 ,2 } , and parity under particle-hole symmetry c =±1 . For each pair of angular momentum quantum numbers J ,Jz , there are two bosonic partners with c =±1 . Based on this spectrum, Nambu proposed a sum rule connecting the fermion and boson masses for BCS-type theories, which for 3He-B is MJ,+ 2+MJ,- 2=4 mF2 for each family of bosonic modes labeled by J , where MJ ,c is the mass of the bosonic mode with quantum numbers (J ,c ) . The Nambu sum rule (NSR) has recently been discussed in the context of Nambu-Jona-Lasinio models for physics beyond the standard model to speculate on possible partners to the recently discovered Higgs boson at higher energies. Here, we point out that the Nambu fermion-boson mass relations are not exact. Corrections to the bosonic masses from (i) leading-order strong-coupling corrections to BCS theory, and (ii) polarization of the parent fermionic vacuum lead to violations of the sum rule. Results for these mass corrections are given in both the T →0 and T →Tc limits. We also discuss experimental results, and theoretical analysis, for the masses of the Jc=2± Higgs modes and the magnitude of the violation of the NSR.

  8. Importance of pseudoscalar-axial-vector mixing in calculation of the properties of the π, η, and η' mesons

    NASA Astrophysics Data System (ADS)

    Celenza, L. S.; Huang, Bo; Shakin, C. M.

    1999-05-01

    In this work we resolve a problem that arises in the calculation of the two-photon decay of the π0, η, and η' mesons, when use is made of the Nambu-Jona-Lasinio (NJL) model. It has been found that satisfactory results for the widths are obtained if a momentum cutoff is not introduced in the evaluation of the (convergent) integrals obtained from an analysis of the triangle diagram, while only about one-half of the experimental value is obtained, if the cutoff used for the (divergent) loop integrals of the NJL model is introduced. The resolution of this problem lies in the introduction of pseudoscalar-axial-vector mixing for both the π0 and the η-η' system. (In addition, one has singlet-octet mixing for the η and η', requiring the study of T matrices of dimension four in that case.) Since we have used a relativistic quark model that includes a (covariant) confinement model, we are able to treat the η' and η mesons on the same basis. We found that the 't Hooft interaction does not work well in our study of η-η' mixing, while the parametrization of nonperturbative effects due to coupling to gluonic modes, which affects the strength of the interaction for singlet states only, yields satisfactory results. In the case of a pion, our results may be understood by the observation that the vertex iP/γ5/P2 yields a much larger amplitude for two-photon decay of a meson of momentum P than the vertex iγ5. Therefore, quite small mixing angles can yield a large modification of the calculated width. We have found that our results are sensitive to the form of regulator used. For example, with a sharp cutoff, Γη'-->γγ is overestimated by about a factor of 3, while the use of a Gaussian regulator leads to a satisfactory fit to the experimental value.

  9. Two-dimensional Fourier transform electronic spectroscopy at a conical intersection

    SciTech Connect

    Kitney-Hayes, Katherine A.; Ferro, Allison A.; Tiwari, Vivek; Jonas, David M.

    2014-03-28

    We report measurement and modeling of two-dimensional (2D) electronic spectra of a silicon naphthalocyanine (SiNc) in benzonitrile, a system for which the polarization anisotropy reveals passage through a square-symmetric Jahn-Teller conical intersection in ∼100 fs [D. A. Farrow, W. Qian, E. R. Smith, A. A. Ferro, and D. M. Jonas, J. Chem. Phys. 128, 144510 (2008)]. The measured 2D Fourier transform (FT) spectra indicate loss of electronic coherence on a similar timescale. The 2D spectra arising from femtosecond vibronic dynamics through the conical funnel are modeled by full non-adiabatic treatment of the coupled electronic and vibrational dynamics for a pair of un-damped Jahn-Teller active vibrations responsible for both electronic decoherence and population transfer. Additional damped Jahn-Teller active modes that can cause only decoherence or population transfer are treated with analytical response functions that can be incorporated into the numerical non-adiabatic calculation by exploiting symmetry assignment of degenerate vibronic eigenstates to one of two electronic states. Franck-Condon active totally symmetric modes are incorporated analytically. The calculations reveal that these conical intersection dynamics alone are incapable of destroying the coherence of the initially prepared wavepacket on the experimentally observed timescale and predict an unobserved recurrence in the photon echo slice at ∼200 fs. Agreement with the experimental two-dimensional electronic spectra necessitates a role for totally symmetric vibrational dynamics in causing the echo slice to decay on a ∼100 fs timescale. This extended model also reproduces the ∼100 fs ultrafast electronic anisotropy decay in SiNc when an “asymmetric solvation mode” with a small stabilization energy of ∼2 cm{sup −1} is included. Although calculations show that inhomogeneities in the energy gap between excited states can broaden the anti-diagonal 2D lineshape, the anti-diagonal width is

  10. Dynamical generation of Majorana masses

    SciTech Connect

    Abada, A.; Le Yaouanc, A.; Oliver, L.; Pene, O.; Raynal, J. )

    1990-09-01

    We address the general question of the dynamical generation of Majorana masses through quartic interactions of the Nambu--Jona-Lasinio (NJL) type that have both chiral and lepton-number invariances. We make composite the Higgs field of the schemes of spontaneous breaking of the leptonic number; we can thus assign to it a leptonic number {vert bar}{ital L}{vert bar}=2 in a natural way. We consider a Weyl field and write a quartic self-interaction for this field that dynamically breaks chiral and fermion-number invariances and exhibits a whole spectrum of composite particles with different quantum numbers, in addition to a Goldstone Majoron. We compare in detail the Dirac and the Majorana cases. The vacuum degeneracy is the same in both cases, but the vacuum invariances are not. For a single fermion species, we have for the Dirac case a U(1){sub {ital V}{minus}{ital A}}{times}U(1){sub {ital V}+{ital A}} invariance that breaks down to U(1){sub {ital V}} and for the Majorana case a single U(1) invariance that breaks down to the identity {ital open}1. In general the Schwinger-Dyson equation is not the same for both cases, since for Majorana fermions we have propagators of several types. However, in the particular case of a NJL {ital contact} interaction (for Majorana fermions this is {ital the} {ital only} {ital nonvanishing} {ital contact} {ital quartic}/{ital B} {ital interaction}), and with a convenient convention for the coupling, the Schwinger-Dyson equation turns out to have the same form for Dirac and for Majorana fermions. The bound-state boson spectrum is quite different in both cases: for the Dirac case, one has a spectrum {sup 2{ital S}+1}{ital L}{sub {ital J}}({ital S}=0,1) {ital J}{sup {ital P}{ital C}}=0{sup {minus}+},1{sup {minus}{minus}},0{sup ++},1{sup ++},1{sup +{minus}},2{sup ++},. . .

  11. Role of the 't Hooft interaction in the calculation of the properties of scalar mesons

    NASA Astrophysics Data System (ADS)

    Shakin, C. M.

    2002-06-01

    A survey of the literature dealing with the quark-model configurations of the scalar-isoscalar light mesons suggests that a theoretical model is needed to deal with these characterizations, since various researchers have come to widely different conclusions concerning the nature of the σ(500 600) or the f0(980), basing their analysis on an attempt to fit experimental data with models for the wave functions of these states. In an earlier work we demonstrated that our generalized Nambu Jona-Lasinio model may be used to provide a very good fit to the mixing angles and decay constants of the η(547) and η'(958) mesons. It was found that the η(547) was mainly a flavor octet state. On the other hand, when we use our model to describe the scalar-isoscalar f0(980) meson, we find that it is mainly a singlet state, in agreement with the recent suggestion of Ochs. We stress that these results for the properties of the pseudoscalar and scalar mesons arise from the different behavior of the ’t Hooft interaction in the two cases. In this work we demonstrate that the singlet-octet flavor representation largely brings the interaction matrix to diagonal form, with some residual singlet-octet mixing due, in part, to the ’t Hooft interaction and to the difference of the up (or down) and the strange quark constituent mass values. We find that, if we neglect the coupling to the two-meson continuum and use the same interaction that was used in our study of the η mesons, the f0(980) has a mass of 981 MeV and is the qq¯ state of lowest energy. That result implies that the σ(500 600) is not a qq¯ state, but is generated dynamically in ππ scattering, as well have discussed in an earlier work. We suggest that the proper treatment of the ’t Hooft interaction leads to a unified interpretation of the pseudoscalar and scalar meson characteristics.

  12. Collective excitations in a superfluid of color-flavor locked quark matter

    SciTech Connect

    Fukushima, Kenji; Iida, Kei

    2005-04-01

    We investigate collective excitations coupled with baryon density in a system of massless three-flavor quarks in the collisionless regime. By using the Nambu-Jona-Lasinio (NJL) model in the mean-field approximation, we field-theoretically derive the spectra both for the normal and color-flavor locked (CFL) superfluid phases at zero temperature. In the normal phase, we obtain usual zero sound as a low-lying collective mode in the particle-hole (vector) channel. In the CFL phase, the nature of collective excitations varies in a way dependent on whether the excitation energy, {omega}, is larger or smaller than the threshold given by twice the pairing gap {delta}, at which pair excitations with nonzero total momentum become allowed to break up into two quasiparticles. For {omega}<<2{delta}, a phonon corresponding to fluctuations in the U(1) phase of {delta} appears as a sharp peak in the particle-particle ('H') channel. We reproduce the property known from low-energy effective theories that this mode propagates at a velocity of v{sub H}=1/{radical}(3) in the low momentum regime; the decay constant f{sub H} obtained in the NJL model is identical with the QCD result obtained in the mean-field approximation. We also find that, as the momentum of the phonon increases, the excitation energy goes up and asymptotically approaches {omega}=2{delta}. Above the threshold for pair excitations ({omega}>2{delta}), zero sound manifests itself in the vector channel. By locating the zero sound pole of the vector propagator in the complex energy plane, we investigate the attenuation and energy dispersion relation of zero sound. In the long wavelength limit, the phonon mode, the only low-lying excitation, has its spectral weight in the H channel alone, while the spectral function vanishes in the vector channel. This is due to nontrivial mixing between the H and vector channels in the superfluid medium. We finally extend our study to the case of nonzero temperature. We demonstrate how

  13. Heating (gapless) color-flavor locked quark matter

    SciTech Connect

    Fukushima, Kenji; Kouvaris, Chris; Rajagopal, Krishna

    2005-02-01

    We explore the phase diagram of neutral quark matter at high baryon density as a function of the temperature T and the strange quark mass M{sub s}. At T=0, there is a sharp distinction between the insulating color-flavor locked (CFL) phase, which occurs where M{sub s}{sup 2}/{mu}<2{delta}, and the metallic gapless CFL phase, which occurs at larger M{sub s}{sup 2}/{mu}. Here, {mu} is the chemical potential for quark number and {delta} is the gap in the CFL phase. We find this distinction blurred at T{ne}0, as the CFL phase undergoes an insulator to metal crossover when it is heated. We present an analytic treatment of this crossover. At higher temperatures, we map out the phase transition lines at which the gap parameters {delta}{sub 1}, {delta}{sub 2}, and {delta}{sub 3} describing ds pairing, us pairing and ud pairing, respectively, go to zero in an Nambu-Jona-Lasinio (NJL) model. For small values of M{sub s}{sup 2}/{mu}, we find that {delta}{sub 2} vanishes first, then {delta}{sub 1}, then {delta}{sub 3}. We find agreement with a previous Ginzburg-Landau analysis of the form of these transitions and find quantitative agreement with results obtained in full QCD at asymptotic density for ratios of coefficients in the Ginzburg-Landau potential. At larger M{sub s}{sup 2}/{mu}, we find that {delta}{sub 1} vanishes first, then {delta}{sub 2}, then {delta}{sub 3}. Hence, we find a ''doubly critical'' point in the (M{sub s}{sup 2}/{mu},T) plane at which two lines of second order phase transitions ({delta}{sub 1}{yields}0 and {delta}{sub 2}{yields}0) cross. Because we do not make any small-M{sub s} approximation, if we choose a relatively strong coupling leading to large gap parameters, we are able to pursue the analysis of the phase diagram all the way up to such large values of M{sub s} that there are no strange quarks present.

  14. Temporal Variability of Methane Flares on the Cascadia Margin Imaged with Swath Bathymetric Data (Ancillary Data to Cascadia Initiative Cruise AT26-02)

    NASA Astrophysics Data System (ADS)

    Trehu, A. M.

    2013-12-01

    Livelybrooks (Un. of Oregon), undergraduates participating in summer research programs at (Elizabeth Davis, Indiana Un. and Oregon State Un. REU program in Oceanography; David Clemens-Sewall, Dartmouth College and IRIS intern), community college students and faculty (Haley Domer, Portland CC; Jonas Cervantes and Greg Mulder, Linn-Benton CC), and graduate students and scientists who had applied to sailed on a Cascadia Initiative cruise (Bridget Hass, Oregon State Un.; Katherine Kirk, Cornell Un. and WHOI; Anton Ypma, Western Washington Un.; Lexi Black, CA State Un. Northridge; Samantha Black, College of Charleston). WHOI marine technician Rob Hagg and MATE Intern Arianna Johns also contributed significantly to this effort.

  15. Local Geostatistical Models and Big Data in Hydrological and Ecological Applications

    NASA Astrophysics Data System (ADS)

    Hristopulos, Dionissios

    2015-04-01

    helps to overcome a significant computational bottleneck of geostatistical models due to the poor scaling of the matrix inversion [4,5]. We present applications to real and simulated data sets, including the Walker lake data, and we investigate the SLI performance using various statistical cross validation measures. References [1] T. Hofmann, B. Schlkopf, A.J. Smola, Annals of Statistics, 36, 1171-1220 (2008). [2] D. T. Hristopulos, SIAM Journal on Scientific Computing, 24(6): 2125-2162 (2003). [3] D. T. Hristopulos and S. N. Elogne, IEEE Transactions on Signal Processing, 57(9): 3475-3487 (2009) [4] G. Jona Lasinio, G. Mastrantonio, and A. Pollice, Statistical Methods and Applications, 22(1):97-112 (2013) [5] Sun, Y., B. Li, and M. G. Genton (2012). Geostatistics for large datasets. In: Advances and Challenges in Space-time Modelling of Natural Events, Lecture Notes in Statistics, pp. 55-77. Springer, Berlin-Heidelberg.

  16. The influence of solution composition and grain boundaries on the replacement of calcite by dolomite

    NASA Astrophysics Data System (ADS)

    Moraila Martinez, Teresita de Jesus; Putnis, Christine V.; Putnis, Andrew

    2016-04-01

    microreactors during reactive fluid flow: experimental dolomitization of a calcite marble. Contributions to Mineralogy and Petrology. 168:1045. 2. Jonas L., Müller T., Dohmen R., Baumgartner L., Putlitz B. (2015). Transport-controlled hydrothermal replacement of calcite by Mg-carbonates. Geology. doi:10.1130/G36934.1 3. Kaczmarek S.E., Sibley D.F., (2011). On the evolution of dolomite stoichiometry and cation order during high-temperature synthesis experiments: An alternative model for geochemical evolution of natural dolomites. Sedimentary Geology. 246, 30-40.

  17. Quantum field theory on toroidal topology: Algebraic structure and applications

    NASA Astrophysics Data System (ADS)

    Khanna, F. C.; Malbouisson, A. P. C.; Malbouisson, J. M. C.; Santana, A. E.

    2014-05-01

    The development of quantum theory on a torus has a long history, and can be traced back to the 1920s, with the attempts by Nordström, Kaluza and Klein to define a fourth spatial dimension with a finite size, being curved in the form of a torus, such that Einstein and Maxwell equations would be unified. Many developments were carried out considering cosmological problems in association with particle physics, leading to methods that are useful for areas of physics, in which size effects play an important role. This interest in finite size effect systems has been increasing rapidly over the last decades, due principally to experimental improvements. In this review, the foundations of compactified quantum field theory on a torus are presented in a unified way, in order to consider applications in particle and condensed matter physics. The theory on a torus ΓDd=(S1)d×RD-d is developed from a Lie-group representation and c*c*-algebra formalisms. As a first application, the quantum field theory at finite temperature, in its real- and imaginary-time versions, is addressed by focusing on its topological structure, the torus Γ41. The toroidal quantum-field theory provides the basis for a consistent approach of spontaneous symmetry breaking driven by both temperature and spatial boundaries. Then the superconductivity in films, wires and grains are analyzed, leading to some results that are comparable with experiments. The Casimir effect is studied taking the electromagnetic and Dirac fields on a torus. In this case, the method of analysis is based on a generalized Bogoliubov transformation, that separates the Green function into two parts: one is associated with the empty space-time, while the other describes the impact of compactification. This provides a natural procedure for calculating the renormalized energy-momentum tensor. Self interacting four-fermion systems, described by the Gross-Neveu and Nambu-Jona-Lasinio models, are considered. Then finite size effects on

  18. HYBRID STARS IN THE LIGHT OF THE MASSIVE PULSAR PSR J1614-2230

    SciTech Connect

    Lenzi, C. H.; Lugones, G. E-mail: german.lugones@ufabc.edu.br

    2012-11-01

    We perform a systematic study of hybrid star configurations using several parameterizations of a relativistic mean-field hadronic equation of state (EoS) and the Nambu-Jona-Lasinio (NJL) model for three-flavor quark matter. For the hadronic phase we use the stiff GM1 and TM1 parameterizations, as well as the very stiff NL3 model. In the NJL Lagrangian we include scalar, vector, and 't Hooft interactions. The vector coupling constant g{sub v} is treated as a free parameter. We also consider that there is a split between the deconfinement and the chiral phase transitions which is controlled by changing the conventional value of the vacuum pressure -{Omega}{sub 0} in the NJL thermodynamic potential by -({Omega}{sub 0} + {delta}{Omega}{sub 0}), with {delta}{Omega}{sub 0} a free parameter. We find that, as we increase the value of {delta}{Omega}{sub 0}, hybrid stars have a larger maximum mass but are less stable, i.e., hybrid configurations are stable within a smaller range of central densities. For large enough {delta}{Omega}{sub 0}, stable hybrid configurations are not possible at all. The effect of increasing the coupling constant g{sub v} is very similar. We show that stable hybrid configurations with a maximum mass larger than the observed mass of the pulsar PSR J1614-2230 are possible for a large region of the parameter space of g{sub v} and {delta}{Omega}{sub 0} provided the hadronic EoS contains nucleons only. When the baryon octet is included in the hadronic phase, only a very small region of the parameter space allows an explanation of the mass of PSR J1614-2230. We compare our results with previous calculations of hybrid stars within the NJL model. We show that it is possible to obtain stable hybrid configurations also in the case {delta}{Omega}{sub 0} = 0 that corresponds to the conventional NJL model for which the pressure and density vanish at zero temperature and chemical potential.

  19. Reader-Centered Technical Writing

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2012-12-01

    an old schema. This reinforces basic engineering and mathematical design concepts. Accommodation: Here, it may work in a different manner. Writers may have to accommodate an old schema to a new object. This helps engineers to focus more on applications. Adaptation: Assimilation and accommodation are the two sides of adaptation, Jean Piaget's term for what most of us would call learning. Mathematical design concepts generated by students should be suitable for creative engineering applications. References : Phillips, D. C. and Soltis, Jonas F. (2003) "Piagetian Structures and Psychological Constructivism," in Perspectives on Learning (4th edition). New York: Teachers College Press. Salvo, Michael J. (2001). Ethics of Engagement: User-Centered Design and Rhetorical Methodology. Technical Communication Quarterly Volume 10, Issue 3, 2001. pages 273-290. http://www.ship.edu/~cgboeree/piaget.html http://owl.english.purdue.edu/owl/resource/624/01/

  20. Missed connections: A case study of the social networks of physics doctoral students in a single department

    NASA Astrophysics Data System (ADS)

    Knaub, Alexis Victoria

    research decreases the time to degree. Only research peer network and departmental information network variables remain in this model. Suggestions for further research for both physics/STEM education and social network analysis are included. Suggestions for ways in which the Jonas University physics department can improve its climate are also included. Although these suggestions are written based upon the Jonas University data, they may be applicable to other physics/STEM graduate programs.

  1. Communicating climate change: alerting versus stimulating action, a few "philosophical" interrogations from a marine biogeochemist

    NASA Astrophysics Data System (ADS)

    Ragueneau, O.

    2009-04-01

    can come to calculate their own emissions and then, replace them in a more global context. During the debates then, very rapidly, politics and ethics come into play. Beyond the question raised above concerning outreach versus engagement, I find it VERY DIFFICULT to find the right balance between alerting and stimulating action. On one hand, we need to alert on the reality of the numbers given (and it is hard to reduce our personal emissions by a factor of 4 in France or 10 in the US), the ethical problems they raise (we, in developed countries, are responsible for the majority of past CO2 emissions and we should do the major effort, Ragueneau et al., 2008). And on the other hand, we need to remain optimistic and show that solutions do exist, if we do not want to discourage people to act. There is debate between the ethics of fear (H. Jonas) and the ethics of hope (E. Morin) as best ways to stimulate action and I feel we need to share our experiences on how best navigate between these two lines. So I would be very happy to participate in such a session to discuss the role of scientists in essential issues such as societal debates related to climate change, the frontier between outreach and political engagement, and the attitude needed to convince that there is a problem, that this problem is big and we need to stress it, but that it can be addressed with very positive implications for each of us.

  2. 2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.

    PubMed

    2012-04-01

    Third Edition [Formula: see text] [Box: see text] Printed with permission from the International Society for Biological and Environmental Repositories (ISBER) © 2011 ISBER All Rights Reserved Editor-in-Chief Lori D. Campbell, PhD Associate Editors Fay Betsou, PhD Debra Leiolani Garcia, MPA Judith G. Giri, PhD Karen E. Pitt, PhD Rebecca S. Pugh, MS Katherine C. Sexton, MBA Amy P.N. Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use. Sharing successful strategies for accomplishing this goal is one of the driving forces for the International Society for Biological and Environmental Repositories (ISBER). For more information about ISBER see www.isber.org . ISBER's Best Practices for Repositories (Best Practices) reflect the collective experience of its members and has received broad input from other repository professionals. Throughout this document

  3. Reconstruction of 3d grain boundaries from rock thin sections, using polarised light

    NASA Astrophysics Data System (ADS)

    Markus Hammes, Daniel; Peternell, Mark

    2016-04-01

    Grain boundaries affect the physical and chemical properties of polycrystalline materials significantly by initiating reactions and collecting impurities (Birchenall, 1959), and play an essential role in recrystallization (Doherty et al. 1997). In particular, the shape and crystallographic orientation of grain boundaries reveal the deformation and annealing history of rocks (Kruhl and Peternell 2002, Kuntcheva et al. 2006). However, there is a lack of non-destructive and easy-to-use computer supported methods to determine grain boundary geometries in 3D. The only available instrument using optical light to measure grain boundary angles is still the polarising microscope with attached universal stage; operated manually and time-consuming in use. Here we present a new approach to determine 3d grain boundary orientations from 2D rock thin sections. The data is recorded by using an automatic fabric analyser microscope (Peternell et al., 2010). Due to its unique arrangement of 9 light directions the highest birefringence colour due to each light direction and crystal orientation (retardation) can be determined at each pixel in the field of view. Retardation profiles across grain boundaries enable the calculation of grain boundary angle and direction. The data for all positions separating the grains are combined and further processed. In combination with the lateral position of the grain boundary, acquired using the FAME software (Hammes and Peternell, in review), the data is used to reconstruct a 3d grain boundary model. The processing of data is almost fully automatic by using MATLAB®. Only minor manual input is required. The applicability was demonstrated on quartzite samples, but the method is not solely restricted on quartz grains and other birefringent polycrystalline materials could be used instead. References: Birchenall, C.E., 1959: Physical Metallurgy. McGraw-Hill, New York. Doherty, R.D., Hughes, D.A., Humphreys, F.J., Jonas, J.J., Juul Jensen, D., Kassner, M

  4. Annotated type catalogue of the Bulimulidae (Mollusca, Gastropoda, Orthalicoidea) in the Natural History Museum, London

    PubMed Central

    Breure, Abraham S.H.; Ablett, Jonathan D.

    2014-01-01

    , 1909; Bulimus (Otostomus) napo Angas, 1878; Drymaeus notabilis da Costa, 1906; Drymaeus notatus da Costa, 1906; Bulimulus (Drymaeus) nubilus Preston, 1903; Drymaeus obliquistriatus da Costa, 1901; Bulimus (Drymaeus) ochrocheilus E.A. Smith, 1877; Bulimus (Drymaeus) orthostoma E.A. Smith, 1877; Drymaeus expansus perenensis da Costa, 1901; Bulimulus pergracilis Rolle, 1904; Bulimulus (Drymaeus) plicatoliratus da Costa, 1898; Drymaeus prestoni da Costa, 1906; Drymaeus punctatus da Costa, 1907; Bulimus (Leptomerus) sanctaeluciae E.A. Smith, 1889; Bulimulus (Drymaeus) selli Preston, 1909; Drymaeus subventricosus da Costa, 1901; Bulimulus (Drymaeus) tigrinus da Costa, 1898; Drymaeus volsus Fulton, 1907; Drymaeus wintlei Finch, 1929; Bulimus zhorquinensis Angas, 1879; Bulimulus (Drymaeus) ziczac da Costa, 1898. The following junior subjective synonyms are established: Bulimus antioquensis Pfeiffer, 1855 = Bulimus baranguillanus Pfeiffer, 1853; Drymaeus bellus da Costa, 1906 = Drymaeus blandi Pilsbry, 1897; Bulimus hachensis Reeve 1850 = Bulimus gruneri Pfeiffer, 1846 = Bulimus columbianus Lea, 1838; Bulimus (Otostomus) lamas Higgins 1868 = Bulimus trujillensis Philippi, 1867; Bulimulus (Drymaeus) binominis lascellianus E.A. Smith, 1895 = Bulimulus (Drymaeus) binominis E.A. Smith, 1895; Drymaeus multispira da Costa, 1904 = Helix torallyi d’Orbigny, 1835; Bulimulus (Drymaeus) plicatoliratus Da Costa, 1898 = Bulimus convexus Pfeiffer, 1855; Bulimus sugillatus Pfeiffer, 1857 = Bulimus rivasii d’Orbigny, 1837; Bulimus meridionalis Reeve 1848 [June] = Bulimus voithianus Pfeiffer, 1847. New combinations are: Bostryx montagnei (d’Orbigny, 1837); Bostryx obliquiportus (da Costa, 1901); Bulimulus heloicus (d’Orbigny, 1835); Drymaeus (Drymaeus) lusorius (Pfeiffer, 1855); Drymaeus (Drymaeus) trigonostomus (Jonas, 1844); Drymaeus (Drymaeus) wintlei Finch, 1929; Drymaeus (Mesembrinus) conicus da Costa, 1907; Kuschelenia (Kuschelenia) culminea culminea (d’Orbigny, 1835

  5. Strong Coupling Gauge Theories in LHC ERA

    NASA Astrophysics Data System (ADS)

    Fukaya, H.; Harada, M.; Tanabashi, M.; Yamawaki, K.

    2011-01-01

    Higgs, or techni-dilaton - composite Higgs near conformality / Koichi Yamawaki -- Phase diagram of strongly interacting theories / Francesco Sannino -- Resizing conformal windows / O. Antipin and K. Tuominen -- Nearly conformal gauge theories on the lattice / Zoltan Fodor ... [et al.] -- Going beyond QCD in lattice gauge theory / G. T. Fleming -- Phases of QCD from small to large N[symbol]: (some) lattice results / A. Deuzeman, E. Pallante and M. P. Lombardo -- Lattice gauge theory and (quasi)-conformal technicolor / D. K. Sinclair and J. B. Kogut -- Study of the running coupling constant in 10-flavor QCD with the Schrodinger functional method / N. Yamada ... [et al.] -- Study of the running coupling in twisted Polyakov scheme / T. Aoyama ... [et al.].Running coupling in strong gauge theories via the lattice / Zoltan Fodor ... [et al.] -- Higgsinoless supersymmetry and hidden gravity / Michael L. Graesser, Ryuichiro Kitano and Masafumi Kurachi -- The latest status of LHC and the EWSB physics / S. Asai -- Continuum superpartners from supersymmetric unparticles / Hsin-Chia Cheng -- Review of minimal flavor constraints for technicolor / Hidenori S. Fukano and Francesco Sannino -- Standard model and high energy Lorentz violation / Damiano Anselmi -- Dynamical electroweak symmetry breaking and fourth family / Michio Hashimoto -- Holmorphic supersymmetric Nambu-Jona-Lasino model and dynamical electroweak symmetry breaking / Dong-Won Jung, Otto C. W. Kong and Jae Sik Lee -- Ratchet model of Baryogenesis / Tatsu Takeuchi, Azusa Minamizaki and Akio Sugamoto -- Classical solutions of field equations in Einstein Gauss-Bonnet gravity / P. Suranyi, C. Vaz and L. C. R. Wijewardhana -- Black holes constitute all dark matter / Paul H. Frampton -- Electroweak precision test and Z [symbol] in the three site Higgsless model / Tomohiro Abe -- Chiral symmetry and BRST symmetry breaking, quaternion reality and the lattice simulation / Sadataka Furui -- Holographic techni-dilaton, or

  6. Geology and ground-water resources of Washington, D.C., and vicinity

    USGS Publications Warehouse

    Johnston, Paul McKelvey

    1964-01-01

    The area of this report includes 436 square miles centered about the District of Columbia. The area contains parts of two distinctly different physiographic provinces-the Piedmont and the Coastal Plain. The Fall Line, which separates the Piedmont province on the west from the Coastal Plain Province on the east, bisects the area diagonally from northeast to southwest. Northwest of the Fall Line, deeply weathered igneous and metamorphic rocks are exposed ; to the southeast, these rocks are covered by Coastal Plain sediments; the nonconformity between crystalline rock and sediments dips southeast at an average rate of about 125 feet per mile. The rocks of the Piedmont include: (1) schist, phyllite, and quartzite of the Wissahickon Formation; (2) altered mafic rocks such as greenstone and serpentine; (3) the Laurel Gneiss of Chapman, 1942, and the Sykesville Formation of Jonas, 1928--both probably derived from the Wissahickon ; and (4) later granitic intrusive rocks. Lying upon this basement of hard rocks east of the Fall Line are the generally unconsolidated sediments of the Coastal Plain, which include gravel, sand, and clay, ranging in age from Cretaceous to Recent. These sediments measure only a few inches at their western extremity but thicken to 1,800 feet at the southeast corner of the mapped area. Owing to the great diversity in the geology of the two provinces, the waterbearing characteristics of the rocks also vary greatly. In the Piedmont, ground water occurs under unconfined or water-table conditions in openings and fissures in the hard rocks or in the residual weathered blanket that overlies them. In the Coastal Plain, the shallow wells tap unconfined water, but beneath the upper clay layers the water is contained in the sand and gravel under artesian pressure and must be recovered by deep drilled wells. Wells are of three types--drilled, bored, and dug. Drilled wells furnish a permanent water supply and are the least subject to pollution when properly

  7. EDITORIAL: Focus on Quantum Correlations in Tailored Matter

    NASA Astrophysics Data System (ADS)

    Muramatsu, Alejandro; Pfau, Tilman

    2008-04-01

    molecules L Wang, A Rastelli, S Kiravittaya, P Atkinson, F Ding, C C Bof Bufon, C Hermannstädter, M Witzany, G J Beirne, P Michler and O G Schmidt Effective parameters for weakly coupled Bose-Einstein condensates S Giovanazzi, J Esteve and M K Oberthaler Current statistics of correlated charge tunnelling through an impurity in a 1D wire Alexander Herzog and Ulrich Weiss Sideband cooling and coherent dynamics in a microchip multi-segmented ion trap Stephan A Schulz, Ulrich Poschinger, Frank Ziesel and Ferdinand Schmidt-Kaler The trapped two-dimensional Bose gas: from Bose-Einstein condensation to Berezinskii-Kosterlitz-Thouless physics Z Hadzibabic, P Krüger, M Cheneau, S P Rath and J Dalibard Dynamical protection of quantum computation from decoherence in laser-driven cold-ion and cold-atom systems Goren Gordon and Gershon Kurizki Spin-flip and spin-conserving optical transitions of the nitrogen-vacancy centre in diamond Ph Tamarat, N B Manson, J P Harrison, R L McMurtrie, A Nizovtsev, C Santori, R G Beausoleil, P Neumann, T Gaebel, F Jelezko, P Hemmer and J Wrachtrup Superconductivity in the attractive Hubbard model: functional renormalization group analysis R Gersch, C Honerkamp and W Metzner Quantum stability of Mott-insulator states of ultracold atoms in optical resonators Jonas Larson, Sonia Fernández-Vidal, Giovanna Morigi and Maciej Lewenstein

  8. FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

    NASA Astrophysics Data System (ADS)

    Suominen, Kalle-Antti

    2010-09-01

    information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

  9. EDITORIAL: Van der Waals interactions in advanced materials, in memory of David C Langreth Van der Waals interactions in advanced materials, in memory of David C Langreth

    NASA Astrophysics Data System (ADS)

    Hyldgaard, Per; Rahman, Talat S.

    2012-10-01

    Rahman Frictional temperature rise in a sliding physisorbed monolayer of Kr/grapheneM Walker, C Jaye, J Krim and Milton W Cole How to modify the van der Waals and Casimir forces without change of the dielectric permittivityG L Klimchitskaya, U Mohideen and V M Mostepanenko Spectroscopic characterization of van der Waals interactions in a metal organic framework with unsaturated metal centers: MOF-74-MgNour Nijem, Pieremanuele Canepa, Lingzhu Kong, Haohan Wu, Jing Li, Timo Thonhauser and Yves J Chabal A theoretical study of the hydrogen-storage potential of (H2)4CH4 in metal organic framework materials and carbon nanotubesQ Li and T Thonhauser The influence of dispersion interactions on the hydrogen adsorption properties of expanded graphiteYungok Ihm, Valentino R Cooper, Lujian Peng and James R Morris A DFT-D study of structural and energetic properties of TiO2 modificationsJonas Moellmann, Stephan Ehrlich, Ralf Tonner and Stefan Grimme Spherical-shell model for the van der Waals coefficients between fullerenes and/or nearly spherical nanoclustersJohn P Perdew, Jianmin Tao, Pan Hao, Adrienn Ruzsinszky, Gábor I Csonka and J M Pitarke Dynamical screening of the van der Waals interaction between graphene layersY J Dappe, P G Bolcatto, J Ortega and F Flores Structural evolution of amino acid crystals under stress from a non-empirical density functionalRiccardo Sabatini, Emine Küçükbenli, Brian Kolb, T Thonhauser and Stefano de Gironcoli Physisorption of nucleobases on graphene: a comparative van der Waals studyDuy Le, Abdelkader Kara, Elsebeth Schröder, Per Hyldgaard and Talat S Rahman The role of van der Waals interactions in the adsorption of noble gases on metal surfacesDe-Li Chen, W A Al-Saidi and J Karl Johnson Desorption of n-alkanes from graphene: a van der Waals density functional studyElisa Londero, Emma K Karlson, Marcus Landahl, Dimitri Ostrovskii, Jonatan D Rydberg and Elsebeth Schröder Benchmarking van der Waals density functionals with experimental data