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Sample records for joseph lounana tnis

  1. Joseph

    ERIC Educational Resources Information Center

    Leigh, Kimberly

    2007-01-01

    In this article, the author shares the story of her son, Joseph, who is a gifted child. She suggests that parents should allow and even encourage their children to ask questions and explore the different answers, give positive acknowledgment to what they do, and get excited about learning new things with them. Surrounding children with peers who…

  2. Joseph Ames

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Dr. Joseph Sweetman Ames at his desk at the NACA headquarters. Dr. Ames was a founding member of NACA (National Advisory Committee for Aeronautics), appointed by President Woodrow Wilson in 1915. Ames took on NACA's most challenging assignments but mostly represented physics. He chaired the Foreign Service Committee of the newly-founded National Research Council, oversaw the NACA's patent cross-licensing plan that allowed manufacturers to share technologies. Ames expected the NACA to encourage engineering education. He pressed universities to train more aerodynamicists, then structured NACA to give young engineers on-the-job training. Ames gave the NACA a focused vision that was research-based and decided that aerodynamics was the most important field of endeavor. He championed the work of theorists like Max Munk. The world class wind tunnels at Langley Aeronautical laboratory reflected his vision as well as the faith Congress put in him. Ames became chairman of the NACA main committee in 1927. Two years later he accepted the Collier Trophy on behalf on the NACA. He kept the NACA alive when Herbert Hoover tried to eliminate it and transfer its duties to industry. Ames accepted a nomination by Air Minister Hermann Goring to the Deutsche Akademie der Luftfartforschung. Ames then considered it an honor, many Americans did, and was surprised to learn about the massive Nazi investment in aeronautical infrastructure, then six times larger than the NACA. Ames urged the funding for a second laboratory and expansion of the NACA facilities to prepare for war. A stroke in May 1936 paralyzed the right side of his body. He immediately resigned as chairman of the NACA executive committee and in October 1937 he resigned from the NACA main committee. On June 8, 1944 the NACA officially dedicated its new laboratory in Sunnyvale California to Joseph S. Ames. Ames died in 1943, having never stepped foot in the new laboratory that bears his name; the Ames Aeronautical Laboratory

  3. Joseph Conrad: International Narrator

    ERIC Educational Resources Information Center

    Walker, George

    2004-01-01

    This article discusses the contribution made by Joseph Conrad's fictional writing to our understanding of cultural awareness. Never comfortable with his adopted English culture, Conrad used his experiences in different parts of the world during his career in the merchant navy to explore in his writing aspects of cultural dissonance and cultural…

  4. Jean Baptiste Joseph Fourier

    NASA Astrophysics Data System (ADS)

    Sterken, C.

    2003-03-01

    This paper gives a short account of some key elements in the life of Jean Baptiste Joseph Fourier (1768-1830), specifically his relation to Napoleon Bonaparte. The mathematical approach to Fourier series and the original scepticism by French mathematicians are briefly illustrated.

  5. Joseph Lister's first operation

    PubMed Central

    Richardson, Ruth; Rhodes, Bryan

    2013-01-01

    Joseph Lister was still a medical student in 1851 when he served as house surgeon at University College Hospital, London, under John Erichsen. Here we report the first major operation that Lister accomplished, hitherto apparently missed by biographers. We chart his exemplary dealings with an emergency case of eviscerating stab wound in a woman brought to casualty at night, when he had been in post for less than a month. The case demonstrates Lister's fundamental competence at an early stage in his training. We outline the context of debate and controversy over the repair of lacerated gut at the time, and argue that Lister's period at University College London was profoundly formative.

  6. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN JOSEPH AND SECOND AVENUE ON MAIN STREET. VIEW LOOKING SOUTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  7. Joseph Henry and Astronomy

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    2016-01-01

    Joseph Henry (1797-1878) is best known for his work in electromagnetism and as the first secretary of the Smithsonian Institution. But he was also a pioneer solar physicist, an early advocate of US participation in astrophysics, and a facilitator of international cooperation in astronomy. This paper will briefly trace his role in the development of the US astronomical community from the time he taught astronomy at Princeton in the 1830s through his death, focusing on failed efforts to persuade US astronomers and patrons of astronomy that the best path for US astronomy should be astrophysics. He thought that the US could make a more significant contribution to astronomy science by striking out on a less travelled path rather than competing with the established European observatories.

  8. Joseph (Joe) A. Walker

    NASA Technical Reports Server (NTRS)

    1956-01-01

    In March 1945 Joseph A. Walker joined the National Advisory Committee for Aeronautics' Aircraft Engine Research Laboratory, Cleveland, Ohio, (later NASA's Lewis Research Center, now the Glenn Research Center) as a physicist. He transferred to the NACA High-Speed Flight Research Station, Edwards, California in 1951, as a research pilot. For the next fifteen years Walker served as a pilot at the Edwards flight research facility (today known as NASA's Dryden Flight Research Center) on such projects as the Bell X-1#2 (2 flights, first on August 27, 1951), Bell X-1A (1 flight on July 20, 1955), X-1E (21 flights, first on December 12, 1955), Douglas D-558-I #3 Skystreak (14 flights, first on June 29, 1951), Douglas D-558-II #2 Skyrocket (3 flights, first on April 29, 1955), Douglas D-558-II #3 Skyrocket (2 flights, first on May 7, 1954). On the Douglas X-3, Joe was project pilot and made all 20 flights, the first on August 1, 1954. Joe considered this aircraft the 'worst' plane he ever flew. He flew the Northrup X-4 (2 flights, first on October 18, 1951), Bell X-5 (78 flights, first on January 9, 1952). He also flew programs involving the F-100, F-101, F-102, F-104 and the B-47. Walker made the first NASA flight on the North American X-15 on March 25, 1960. His 25th and final X-15 flight on August 22, 1963, reached 354,200 feet, an unofficial record altitude of almost 67 miles. On October 30, 1964, Walker took the first Bell Lunar Landing Research Vehicle (LLRV) on its maiden flight, reaching a peak altitude of 10 feet and a free flight time of just under one minute. Two LLRV's and three Lunar Landing Training Vehicles developed from them were used to develop piloting and operational techniques for lunar landings. In November, he left the program after 35 flights on the first LLRV. Walker flew chase flights as well as research flights. On June 8, 1966 he was flying chase in NASA's F-104N for the Air Force's experimental bomber, North American XB-70A, when he was fatally

  9. [Joseph Babinski: a complex personality].

    PubMed

    Poirier, Jacques

    2007-10-01

    Joseph Babinski (1857-1932), a Paris hospital neurologist known for the discovery of his eponymous sign, was a highly complex personality. He was known as a handsome but silent "blue-eyed giant". His parents left Poland for Paris after the insurrection of 1848. Joseph and his elder brother Henri (1855-1931) were born in Paris and were therefore French, but they remained devoted to Poland. Joseph suffered from excruciating self-doubt and was meticulous. He was a reasoner and a righter of wrongs. Henri, who trained as a civil engineer at the French National School of Mines, prospected mineral, gold and diamond deposits in various countries. On his return to France at the end of the century, he wrote, under the pseudonym Ali-Bab, a monumental cookbook called "Gastronomie pratique", which was widely acclaimed Joseph and Henri, both unmarried, lived together and formed an inseparable couple. Joseph Babinski had no religious, political or ideological commitments. Some areas of his private life still remain rather shadowy.

  10. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT THE NORTHEAST CORNER OF SECOND AND MAIN, VIEW LOOKING NORTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  11. ASK Talks With Joseph Rothenberg

    NASA Technical Reports Server (NTRS)

    Rothenberg, Joseph

    2002-01-01

    Recently retired NASA administrator Joseph Rothenberg reflects on project management during the Apollo era at the start of his career, as well as the history of, and changes in, project management over his years at NASA. He concludes by describing what he sees as NASA's most important needs in the near future.

  12. Joseph Hooker: a philosophical botanist.

    PubMed

    Endersby, Jim

    2008-06-01

    The nineteenth-century British botanist, Joseph Dalton Hooker,was one of the people whose career became a model for that of the modern,professional scientist.However,he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice,and analyses Hooker's imperial approach to plant classification, the consequences of which are still with us. PMID:18535350

  13. The Birth of Joseph Gabriel

    PubMed Central

    Cantine, Anne Touhill

    2013-01-01

    In this column, a mother shares the story of the birth of her first child. With confidence in the process of birth and in her ability to give birth, and with the support, confidence, and encouragement of her mother and sisters, Anne manages to cope with strong contractions through a busy day. Finally, her husband realizes how fast labor is progressing. Baby Joseph was born less than 2 hours after arrival at the hospital. PMID:24868130

  14. Joseph Hooker: a philosophical botanist.

    PubMed

    Endersby, Jim

    2008-06-01

    The nineteenth-century British botanist, Joseph Dalton Hooker,was one of the people whose career became a model for that of the modern,professional scientist.However,he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice,and analyses Hooker's imperial approach to plant classification, the consequences of which are still with us.

  15. Joseph Priestley and the Psychology of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Joseph Priestley, in his "A Course of Lectures on Oratory and Criticism," developed a psychological theory of style. The "Course" covers three main topics: traditional rhetorical arts of invention, arrangement, and style. Borrowing from the ideas of David Hartley, the association psychologist; Joseph Addison, the aesthetician; and Adam Smith, the…

  16. 75 FR 15430 - Chief Joseph Hatchery Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Bonneville Power Administration Chief Joseph Hatchery Program AGENCY: Bonneville Power Administration (BPA... announces the availability of the ROD to implement the proposed action identified in BPA's Chief Joseph Hatchery Program Environmental Impact Statement (DOE/EIS-0384, November 2009). BPA has decided to fund...

  17. Redox Pioneer: Professor Joseph Loscalzo

    PubMed Central

    2010-01-01

    Abstract Professor Joseph Loscalzo Dr. Joseph Loscalzo (M.D., 1978; Ph.D., 1977) is recognized here as a Redox Pioneer because he has published two articles in the field of antioxidant/redox biology that have been cited more than 1,000 times and 22 articles that have been cited more than 100 times. Dr. Loscalzo is known for his seminal contributions to our understanding of the vascular biology of nitric oxide. His initial discovery that the antiplatelet effects of organic nitrates are potentiated by thiols through a mechanism that involved metabolism to S-nitrosothiols was followed by the demonstration that S-nitrosothiols are formed endogenously through S-transnitrosation, stabilize nitric oxide, and facilitate the transport and transfer of nitric oxide between and within cells of the vessel wall. These properties led to the development of S-nitrosothiol–containing pharmacotherapies to treat disease states characterized by nitric oxide deficiency. Dr. Loscalzo's other scientific contributions include identifying the vascular functional consequences of genetic deficiencies of antioxidant enzymes that decrease nitric oxide bioavailability, collectively termed the “oxidative enzymopathies,” and demonstrating the role of mitochondria in modulating the disulfide subproteome, and in redox signaling in hypoxia. He has received numerous awards and honors for his scientific contributions, including election to the Institute of Medicine of the National Academy of Sciences. Antioxid. Redox Signal. 13, 1125–1132. PMID:20443733

  18. Joseph Maxwell on mediumistic personifications.

    PubMed

    Alvarado, Carlos S

    2016-09-01

    The study of mediumship received much impetus from the work of psychical researchers. This included ideas about the phenomena of personation, or changes in attitudes, dispositions and behaviours shown by some mediums that supposedly indicated discarnate action. The aim of this Classic Text is to reprint passages about this topic from the writings of French psychical researcher Joseph Maxwell (1858-1938), which were part of the contributions of some psychical researchers to reconceptualize the manifestations in psychological terms. Maxwell suggested these changes in mediums were a production of their subconscious mind. His ideas are a reflection of previous theorization about secondary personalities and a particular example of the contributions of psychical researchers to understand the psychology of mediumship.

  19. Joseph Mayer and Statistical Mechanics

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    In the January 1937 issue of the Journal of Chemical Physics (Volume 5) there appeared a paper by Joseph Mayer which was the first of a series of articles. It produced great and immediate impact. The title was "The Statistical Mechanics of Condensing Systems. I," the abstract of this paper is given below: It is shown that for a system composed of N identical molecules with mutual potential energy, the assumption that the total potential energy can be expressed as the sum of that between pairs of molecules allows the derivation of simple, accurate formal equations for the thermodynamic properties of the system. Under certain conditions, generally fulfilled at low temperatures, the equations predict a region where the pressure and Gibb's free energy are independent of volume, the characteristic of condensing sytems. The equations permit calculation of the Gibb's free energy of the liquid in equilibrium with the vapor and all the properties of the saturated vapor, but not the volume or volume dependence of the condensed phase...

  20. Joseph Haydn's encephalopathy: new aspects.

    PubMed

    Blahak, Christian; Bäzner, Hansjörg; Hennerici, Michael G

    2015-01-01

    With increasing age, Joseph Haydn complained of progressive forgetfulness preventing him from composing for about the last 8 years of his life. He spent his days more and more inactive and immobilized, suffering from a disabling gait disturbance. Still, most biographers consider diffuse atherosclerosis and congestive heart failure to be reasons for Haydn's medical condition and physical decline during the last years of his life. A more sophisticated and detailed inspection of documents and sources, however, leads to the diagnosis of subcortical vascular encephalopathy (SVE), caused by progressive cerebral small vessel disease. Important features of the disease are mood changes, urinary symptoms, and in particular a characteristic gait disturbance, while dementia is only mild and occurs later in the course. Haydn was severely disabled by the symptoms of SVE for several years and often reported difficulties in the completion of his last oratorio "Die Jahreszeiten" (The Seasons). Subsequently, the disease prevented him from composing another large oratorio, "Das jüngste Gericht" (The last judgement), which had been already drafted. Finally, the progress of SVE stopped his long career as a composer and conductor at the age of 73 years. PMID:25684297

  1. Joseph Haydn's encephalopathy: new aspects.

    PubMed

    Blahak, Christian; Bäzner, Hansjörg; Hennerici, Michael G

    2015-01-01

    With increasing age, Joseph Haydn complained of progressive forgetfulness preventing him from composing for about the last 8 years of his life. He spent his days more and more inactive and immobilized, suffering from a disabling gait disturbance. Still, most biographers consider diffuse atherosclerosis and congestive heart failure to be reasons for Haydn's medical condition and physical decline during the last years of his life. A more sophisticated and detailed inspection of documents and sources, however, leads to the diagnosis of subcortical vascular encephalopathy (SVE), caused by progressive cerebral small vessel disease. Important features of the disease are mood changes, urinary symptoms, and in particular a characteristic gait disturbance, while dementia is only mild and occurs later in the course. Haydn was severely disabled by the symptoms of SVE for several years and often reported difficulties in the completion of his last oratorio "Die Jahreszeiten" (The Seasons). Subsequently, the disease prevented him from composing another large oratorio, "Das jüngste Gericht" (The last judgement), which had been already drafted. Finally, the progress of SVE stopped his long career as a composer and conductor at the age of 73 years.

  2. Joseph Henry and the Telegraph

    NASA Astrophysics Data System (ADS)

    Hochfelder, David

    1997-04-01

    Morse's telegraph rested upon three scientific advances which occured between 1800 and 1830: the development of battery technology, the formulation of laws governing the behavior of electrical components in circuits, and the discovery of electromagnetic phenomena. Joseph Henry was crucial to the development of the early telegraph. His work on electromagnetism made it possible for the electric current to manifest itself as useful mechanical work. Henry developed electromagnets of sufficient lifting power, but which drew relatively small currents; these magnets were the heart of Morse's telegraph receiver. Morse also used electromagnets as relays, which allowed him to transmit signals over great distances. Morse often acknowledged his debt to Henry, and the two enjoyed a cordial working relationship until the mid-1840s. But during the bitter and protracted litigation over Morse's patent, Henry testified (unwillingly, he claimed) against the inventor. This began a lifelong quarrel between the two men, the specifics of which were tedious and petty. In general terms, however, their conflict arose over different notions regarding scientific discovery and technological innovation.

  3. Noah, Joseph and Convex Hulls

    NASA Astrophysics Data System (ADS)

    Watkins, N. W.; Chau, Y.; Chapman, S. C.

    2010-12-01

    The idea of describing animal movement by mathematical models based on diffusion and Brownian motion has a long heritage. It has thus been natural to account for those aspects of motion that depart from the Brownian by the use of models incorporating long memory & subdiffusion (“the Joseph effect”) and/or heavy tails & superdiffusion (“the Noah effect”). My own interest in this problem was originally from a geoscience perspective, and was triggered by the need to model time series in space physics where both effects coincide. Subsequently I have been involved in animal foraging studies [e.g. Edwards et al, Nature, 2007]. I will describe some recent work [Watkins et al, PRE, 2009] which studies how fixed-timestep and variable-timestep formulations of anomalous diffusion are related in the presence of heavy tails and long range memory (stable processes versus the CTRW). Quantities for which different scaling relations are predicted between the two approaches are of particular interest, to aid testability. I will also present some of work in progress on the convex hull of anomalously diffusing walkers, inspired by its possible relevance to the idea of home range in biology, and by Randon-Furling et al’s recent analytical results in the Brownian case [PRL, 2009].

  4. Rethinking Joseph Janangelo's "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts"

    ERIC Educational Resources Information Center

    College Composition and Communication, 2007

    2007-01-01

    This article presents several excerpts from an article written by Joseph Janangelo titled "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts." In his article, Janangelo suggested that Cornell's work and ideas about composing model intelligent ways to composing persuasive nonsequential text. Janangelo also wondered if the use of…

  5. Joseph Conrad's tormented Rescue (fantasy).

    PubMed

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text.

  6. Joseph Conrad's tormented Rescue (fantasy).

    PubMed

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text. PMID:24555549

  7. 6. View northeast of Ten Acre Lot with Joseph Fry ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View northeast of Ten Acre Lot with Joseph Fry Farm complex (center) and Beehive House (right)in the background - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  8. Joseph Rotblat: Influences, Scientific Achievements and Legacy

    ERIC Educational Resources Information Center

    Underwood, Martin

    2008-01-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to…

  9. Content, Joseph Schwab and German "Didaktik"

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This article attempts to extend and deepen the conversation concerning the knowledge-based approach to curriculum espoused by Michael Young in his 2013 "JCS" paper through revisiting the structure of the disciplines thinking of Joseph Schwab and German "Didaktik." It argues that curriculum making requires a theory of knowledge…

  10. Selected Papers of Joseph T. Impellitteri.

    ERIC Educational Resources Information Center

    Baran, Anna DeSantis; Gilli, Angelo C., Sr.

    1975-01-01

    The collection of selected papers of Joseph T. Impellitteri reprints in full, or excerpts from, 46 unpublished position and conference papers, research and program proposals, and project reports, and from 20 published articles, chapters from edited collections, bulletins and special studies which Impellitteri authored or co-authored. The papers…

  11. Joseph Priestley: Docter Phlogiston or Reverend Oxygen?

    PubMed

    Fara, Patricia

    2010-09-01

    In propaganda material, people are often presented in black-and-white terms as either a villain or a hero. Although Joseph Priestley is denigrated for believing in the discredited substance phlogiston, he is also celebrated for discovering oxygen. PMID:20708802

  12. Dan Joseph's contributions to disperse multiphase flow

    NASA Astrophysics Data System (ADS)

    Prosperetti, Andrea

    2012-11-01

    During his distinguished career, Dan Joseph worked on a vast array of problems. One of these, which occupied him off and on over the last two decades of his life, was that of flows with suspended finite-size particles at finite Reynolds numbers. He realized early on that progress in this field had to rely on the insight gained from numerical simulation, an area in which he was a pioneer. On the basis of the early numerical results he recognized the now famous ``drafting, kissing and tumbling'' mechanism of particle-particle interaction, the possibility of fluidization by lift and many others. With a number of colleagues and a series of gifted students he produced a significant body of work summarized in his on-line book Interrogations of Direct Numerical Simulation of Solid-Liquid Flows available from http://www.efluids.com/efluids/books/joseph.htm. This presentation will describe Joseph's contribution to the understanding of disperse multiphase flow and conclude with some examples from the author's recent work in this area. Supported by NSF.

  13. 10. Historic American Buildings Survey Joseph Hill, Photographer May, 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey Joseph Hill, Photographer May, 1936 EAST ELEVATION - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  14. Interview--Cliff Joseph: Art Therapist, Pioneer, Artist.

    ERIC Educational Resources Information Center

    Riley-Hiscox, Anna

    1997-01-01

    Interview of Cliff Joseph, one of the first African Americans to participate in the American Art Therapy Association and to become a registered art therapist and teacher. Details Joseph's impact on art therapy and cultural and social issues, as well as his relationships with other prominent art therapists. (MKA)

  15. Tribes of Men: John Joseph Mathews and Indian Internationalism

    ERIC Educational Resources Information Center

    Lutenski, Emily

    2012-01-01

    In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

  16. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2....

  17. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... yards west of U.S. Highway 98 Bridge over Gulf County Canal. The area is parallel to and 450...

  18. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... yards west of U.S. Highway 98 Bridge over Gulf County Canal. The area is parallel to and 450...

  19. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false St. Joseph Bay, Fla. 110.193a... ANCHORAGE REGULATIONS Anchorage Grounds § 110.193a St. Joseph Bay, Fla. (a) The anchorage grounds—(1... yards west of U.S. Highway 98 Bridge over Gulf County Canal. The area is parallel to and 450...

  20. Jacques Joseph: Father of modern aesthetic surgery

    PubMed Central

    Bhattacharya, Surajit

    2008-01-01

    When we review the history of modern aesthetic surgery, a name that stands out as bright as a beacon and precious as gold is undoubtedly that of Jacques Joseph. A surgeon, par excellence, far ahead of his time, who chose to think out of the box, Joseph, despite all odds set out to give respectability to Aesthetic Surgery without depriving it of any scientific core values. By his words and deeds proved beyond doubt that only the very best in the field of reconstructive surgery, can visualize the hidden perfection in imperfection and formulate a treatment plan and a surgical strategy to achieve that elusive perfection. The rich surgical literature that he has left behind, the wealth of surgical instruments that he had designed and above all a way of thinking that he propagated, that aesthetic surgery is not frivolous but very serious endeavor, and treating the psychology of the patient is as important as treating his disease, undoubtedly makes him the revered ‘Father of Modern Aesthetic Surgery’. PMID:20174541

  1. Jacques Joseph: Father of modern aesthetic surgery.

    PubMed

    Bhattacharya, Surajit

    2008-10-01

    When we review the history of modern aesthetic surgery, a name that stands out as bright as a beacon and precious as gold is undoubtedly that of Jacques Joseph. A surgeon, par excellence, far ahead of his time, who chose to think out of the box, Joseph, despite all odds set out to give respectability to Aesthetic Surgery without depriving it of any scientific core values. By his words and deeds proved beyond doubt that only the very best in the field of reconstructive surgery, can visualize the hidden perfection in imperfection and formulate a treatment plan and a surgical strategy to achieve that elusive perfection. The rich surgical literature that he has left behind, the wealth of surgical instruments that he had designed and above all a way of thinking that he propagated, that aesthetic surgery is not frivolous but very serious endeavor, and treating the psychology of the patient is as important as treating his disease, undoubtedly makes him the revered 'Father of Modern Aesthetic Surgery'.

  2. Joseph F. Poland (1908-1991)

    NASA Astrophysics Data System (ADS)

    Johnson, A. Ivan

    On June 4, 1991, AGU Fellow Joseph Fairfield Poland died in a Sacramento, Calif., hospital at the age of 83 after a long fight with Parkinson's Disease. A recognized expert on land subsidence and a retiree from the U.S. Geological Survey's Water Resources Division, his death occurred only 2 weeks after the end of the 4th International Symposium on Land Subsidence, held in Houston, Tex. Frequently known as “Mr. Land Subsidence,” it was appropriate that the proceedings of that symposium had been dedicated to him.Born in Boston, Poland earned a bachelor's degree in geology from Harvard University in 1929. He was resident geologist for Tropical Oil Company in Colombia from 1929 to 1931. After returning to the United States, Poland earned his master's degree in geology from Stanford University in 1935, taught groundwater hydrology, and consulted on groundwater and geophysical problems in the West and Southwest.

  3. William Thomson and Joseph Janvier Woodward.

    PubMed

    Zimmerman, L E

    1995-01-01

    William Thomson and Joseph Janvier Woodward were two of several exceptionally versatile and highly productive young physicians who volunteered for service with the Union Army at the outbreak of the Civil War, and then were subsequently assigned to the Washington Area where they played significant roles and made major contributions towards the development of the Army Medical Museum. Both pioneered in photomicrography. While Thomson deserves priority, Woodward was the more prolific contributor whose work and publications helped draw attention to the Army Medical Museum as a center for excellence in pathology. After the War Thomson returned to Philadelphia where his interests in photography stimulated his pursuit of optics and eventually his becoming one of the first American physicians to specialize in ophthalmology. He became Professor of Ophthalmology at Jefferson Medical College.

  4. Joseph F. Rychlak (1928-2013).

    PubMed

    Slife, Brent D

    2014-01-01

    Joseph Frank Rychlak was born on December 17, 1928 and passed away on April 16, 2013. Joe's major contributions to psychology vary widely, as mentioned, but they are all carefully connected to a rigorously humanistic understanding of the person. It may be stretching it to use the phrase "one of the last grand theorists" to describe him and his contribution to psychology. There are still many important living theorists in the field. However, it is not an exaggeration to use the term "grand" because Rychlak's work is nothing if not subsuming, spanning not only the personality and psychotherapy literatures but also works on cognition, humanism, and the philosophy of science. Throughout his long and productive examination of these ideas, Joe remained a man of the highest integrity, vision, and caring.

  5. Joseph Hooker: the making of a botanist.

    PubMed

    Endersby, J

    2001-03-01

    Joseph Hooker became one of the most influential botanists of his day. He is best remembered as a friend of Charles Darwin and an early advocate of natural selection. However, after returning to Britain from his first major voyage, Hooker spent years struggling to find a paid position that would allow him to pursue his studies of plant classification and distribution. As he worked to establish himself, he also helped transform the status of botany as a discipline. In all his efforts, Hooker relied on a network of unpaid, colonial collectors, whose often-forgotten contributions to Victorian natural history are vital to the understanding of the professionalization of the sciences in the 19th century.

  6. 12. Historic American Buildings Survey Joseph Hill, Photographer July 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Joseph Hill, Photographer July 10, 1936 SOUTH ELEVATION (Copied from student's drawing, Dept. of Architecture, Armour Institute of Technology. Chicago) - Keating House, U.S. Highway 430, Fayville, Alexander County, IL

  7. 2. Historic American Buildings Survey Joseph Hill, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer May 10, 1936 CAST IRON GATE AT 1352 W. Washington Blvd., Chicago - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  8. 12. Historic American Buildings Survey Joseph Hill, Photographer Spring 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Joseph Hill, Photographer Spring 1937 DETAIL OF CORNICE AND SECOND FLOOR WINDOW TRIM. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  9. 9. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Joseph Hill, Photographer May 1936 PRESENT WEST + SOUTH ELEVATIONS - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  10. 7. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 NORTH ELEVATION - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  11. 15. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Historic American Buildings Survey Joseph Hill, Photographer May 1936 FRONT HALL, INTERIOR DETAIL - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  12. 13. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 TYPICAL WINDOW, EXTERIOR - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  13. 17. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Historic American Buildings Survey Joseph Hill, Photographer May 1936 LIVING ROOM FIREPLACE (RESTORED) - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  14. 4. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH FURNISHED BY THE COMMANDANT, DATE UNKNOWN - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  15. 14. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 MAIN ENTRANCE - EXTERIOR - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  16. 18. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 FIREPLACE IN DINING ROOM, The Davenport House, Rock Island Arsenal - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  17. 11. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 NORTH ELEVATION - DETAIL OF PORTICO - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  18. 1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH LOANED BY THE COMMANDANT, EARLY PHOTO OF HOUSE DATE UNKNOWN. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  19. 16. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 TYPICAL WINDOW, INTERIOR - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  20. 19. Historic American Buildings Survey Joseph Hill, Photographer COL. DAVENPORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Historic American Buildings Survey Joseph Hill, Photographer COL. DAVENPORT Copy of an old photograph loaned by the commandant. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  1. 5. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH LOANED BY THE COMMANDANT. DATE UNKNOWN - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  2. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #12 EARLY RED BRICK HOUSE, Elk and Prospect Sts., Galena, Illinois - Galena Doorways, Red Brick House, Elk & Prospect Streets, Galena, Jo Daviess County, IL

  3. 7. Detail of balcony rail. August 1936. Joseph Hill, photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail of balcony rail. August 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  4. 6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  5. 3. West and south elevations. Joseph Hill, photographer, copied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West and south elevations. Joseph Hill, photographer, copied from photo lent by Evelyn S. Craig. August 1936. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  6. 1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 FIRST ORIGINAL STORE AND POSTOFFICE, COPY OF AN EARLY PHOTOGRAPH. LENT BY EVELYN S. CRAIG - Jansonist Colony, Colony Store & Post Office, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  7. Cholangicarcinoma Presenting as a Sister Mary Joseph Nodule

    PubMed Central

    Rangegowda, Devaraja; Vyas, Tanmay; Grover, Shrruti; Joshi, YK; Sharma, Chhagan; Sahney, Amrish

    2016-01-01

    Sister Mary Joseph nodules represent metastatic cancer of the umbilicus. More than half of these cases are attributable to gastrointestinal malignancies including gastric, colonic, and pancreatic cancer. In addition, gynecologic (ovarian, uterine cancer), unknown primary tumors, and, rarely, bladder or respiratory malignancies may cause umbilical metastasis. We report the case of a Sister Mary Joseph nodule originating from a hilar cholangiocarcinoma. Umbilical nodules should prompt clinical evaluation, as these tumors are usually associated with poor prognosis. PMID:27144207

  8. Joseph Priestley, oxygen, and the enlightenment.

    PubMed

    West, John B

    2014-01-01

    Joseph Priestley (1733–1804) was the first person to report the discovery of oxygen and describe some of its extraordinary properties. As such he merits a special place in the history of respiratory physiology. In addition his descriptions in elegant 18th-century English were particularly arresting, and rereading them never fails to give a special pleasure. The gas was actually first prepared by Scheele (1742–1786) but his report was delayed. Lavoisier (1743–1794) repeated Priestley's initial experiment and went on to describe the true nature of oxygen that had eluded Priestley, who never abandoned the erroneous phlogiston theory. In addition to oxygen, Priestley isolated and characterized seven other gases. However, most of his writings were in theology because he was a conscientious clergyman all his life. Priestley was a product of the Enlightenment and argued that all beliefs should be able to stand the scientific scrutiny of experimental investigations. As a result his extreme liberal views were severely criticized by the established Church of England. In addition he was a supporter of both the French and American Revolutions. Ultimately his political and religious attitudes provoked a riot during which his home and his scientific equipment were destroyed. He therefore emigrated to America in 1794 where his friends included Thomas Jefferson and Benjamin Franklin. He settled in Northumberland, Pennsylvania although his scientific work never recovered from his forced departure. But the descriptions of his experiments with oxygen will always remain a high point in the history of respiratory physiology.

  9. Joseph Henry's Conception of Scientific Knowledge

    NASA Astrophysics Data System (ADS)

    Theerman, Paul

    1997-04-01

    Joseph Henry, America's premier physicist and physics teacher in the mid-nineteenth century, had decided views of scientific knowledge. These were expressed in two ways. First of all, scientific knowledge led to moral betterment. Thus the study of science was a morally good thing. This was not only because it led to the contemplation of God's creation, which was a standard reason justifying the study of science dating from the Scientific Revolution and even earlier. More importantly, the study of science itself was a moral discipline, imparting to scientists the habits and virtues of truthfulness, respect for others, care and diligence, and the discernment of meaningful patterns from experience. The moral ideals of science were expressed most strongly in Henry's upholding the international "Republic of Science"; conversely, cheapening science was a sign of moral failure. Second, for Henry and his generation, science provided a path to sure truth, separate from falsehood of both the politics and the quackery that characterized mid-century public life. Henry promoted this in his championing of the Smithsonian Institution a scientific establishment, against the ideas of others who wanted to make it a literary establishment or a training school for teachers. For Henry, the Smithsonian's scientific reputation would be established by relying on careful peer review in its publications, and supporting established scientists to write authoritative popular works. The purpose of both these activities was to raise the profile of science in the United States and further establish science and the scientific method as a guide to public life.

  10. Joseph Rotblat: influences, scientific achievements and legacy

    NASA Astrophysics Data System (ADS)

    Underwood, Martin

    2008-11-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to science, and in particular to the medical applications of accelerators, radiation and radio-nuclides. In this article his early work and influences in Poland are described. He then joined James Chadwick at Liverpool University and began work on the cyclotron recently constructed there. Rotblat then, together with Chadwick, joined the Manhattan Project. This experience was to shape his life. He stayed at Los Alamos for less than a year before walking out. He was suspected of being a spy. Rotblat then became Professor of Physics at St Bartholomew's Medical College and pioneered the use of a 15 MeV linear accelerator in treatment and research. He made fundamental contributions to understanding the effects of the fallout from nuclear bomb tests. He also, together with Patricia Lindop, made important contributions to understanding the biological effects of radiation.

  11. Joseph Priestley, oxygen, and the enlightenment.

    PubMed

    West, John B

    2014-01-01

    Joseph Priestley (1733–1804) was the first person to report the discovery of oxygen and describe some of its extraordinary properties. As such he merits a special place in the history of respiratory physiology. In addition his descriptions in elegant 18th-century English were particularly arresting, and rereading them never fails to give a special pleasure. The gas was actually first prepared by Scheele (1742–1786) but his report was delayed. Lavoisier (1743–1794) repeated Priestley's initial experiment and went on to describe the true nature of oxygen that had eluded Priestley, who never abandoned the erroneous phlogiston theory. In addition to oxygen, Priestley isolated and characterized seven other gases. However, most of his writings were in theology because he was a conscientious clergyman all his life. Priestley was a product of the Enlightenment and argued that all beliefs should be able to stand the scientific scrutiny of experimental investigations. As a result his extreme liberal views were severely criticized by the established Church of England. In addition he was a supporter of both the French and American Revolutions. Ultimately his political and religious attitudes provoked a riot during which his home and his scientific equipment were destroyed. He therefore emigrated to America in 1794 where his friends included Thomas Jefferson and Benjamin Franklin. He settled in Northumberland, Pennsylvania although his scientific work never recovered from his forced departure. But the descriptions of his experiments with oxygen will always remain a high point in the history of respiratory physiology. PMID:24285268

  12. Toward understanding Machado-Joseph Disease

    PubMed Central

    Costa, Maria do Carmo; Paulson, Henry L.

    2011-01-01

    Machado-Joseph disease (MJD), also known as Spinocerebellar ataxia type 3 (SCA3), is the most common inherited spinocerebellar ataxia and one of many polyglutamine neurodegenerative diseases. In MJD, a CAG repeat expansion encodes an abnormally long polyglutamine (polyQ) tract in the disease protein, ATXN3. Here we review MJD, focusing primarily on the function and dysfunction of ATXN3 and on advances toward potential therapies. ATXN3 is a deubiquitinating enzyme (DUB) whose highly specialized properties suggest that it participates in ubiquitin-dependent proteostasis. By virtue of its interactions with VCP, various ubiquitin ligases and other ubiquitin-linked proteins, ATXN3 may help regulate the stability or activity of many proteins in diverse cellular pathways implicated in proteotoxic stress response, aging, and cell differentiation. Expansion of the polyQ tract in ATXN3 is thought to promote an altered conformation in the protein, leading to changes in interactions with native partners and to the formation of insoluble aggregates. The development of a wide range of cellular and animal models of MJD has been crucial to the emerging understanding of ATXN3 dysfunction upon polyQ expansion. Despite many advances, however, the principal molecular mechanisms by which mutant ATXN3 elicits neurotoxicity remain elusive. In a chronic degenerative disease like MJD, it is conceivable that mutant ATXN3 triggers multiple, interconnected pathogenic cascades that precipitate cellular dysfunction and eventual cell death. A better understanding of these complex molecular mechanisms will be important as scientists and clinicians begin to focus on developing effective therapies for this incurable, fatal disorder. PMID:22133674

  13. Obituary: Richard Joseph Elston, 1960-2004

    NASA Astrophysics Data System (ADS)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  14. [Joseph Toynbee--otologist, scientist, philanthropist].

    PubMed

    Betlejewski, Stanisław; Betlejewski, Andrzej

    2009-01-01

    Joseph Tonbee's life's work may be summarized in the words of William Wilde: "The labours and investigations of Mr. Toynbee have affected more for aural pathology than those of all his predecessors either in England or on the continent". Some idea of the extent of his researches is given by the fact that he dissected some 2.000 ears. These preparations formed the Toynbee Collection in the Museum of the Royal College of Surgeons of England. He wrote the results of his researches in a catalogue that includes the description of 1,659 human ears. This catalogue forms the basis of modern otology for all time. This purely pathological catalogue was completed in 1860 with the publication of a more clinical book, "The Diseases of the Ear: their Nature, Diagnosis and Treatment". Toynbee appears to have been the first to describe the pathological changes in otosclerosis. In his book "Diseases of the Ear" he described the condition clearly, recognizing "anchylosis of the stapes to the fenestra ovalis" in 136 temporal bones. He also aligned the subjective, visual and ausculatory tests for Eustacchian tubal patency which we use today. Adam Politzer wrote: "Toynbee was the first who realized in otology that therapeutic progress depends on the knowledge of anatomy". But Toynbee was also active on other fields. Politzer, in his lecture in Vienna in 1914 said: "Toynbee was as outstanding a savant as he was a philanthropist. In addition to his scientific activity, he considered it a sacred task to dedicate his spare time to the improvement of living and health conditions of the poorer classes." Tragic enough, Toynbee's zeal for clinical experimentation went too far. Seeking to help his patients by devising a treatment to allay their tinnitus, he conceived the idea of introducing a mixture of chloroform and prussic acid into the tympanic cavity by means of Valsalva maneuver. When he made the first trial on July 7, 1866, with himself as a subject, he was found dead on the couch in his

  15. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael P; Springer, Clint

    2013-10-15

    Task A: Examination of the physiological, morphological, and reproductive responses of Panicum virgatum (switchgrass) cultivars identified as potential biofuel producing cultivars as well as naturally-occurring varieties of switchgrass to projected changes in climate for the central portion of the United States. This project was a multi-year project set in a field site located at the Konza Prairie Biological Station near Manhattan, KS USA. At the field site we planted switchgrass collected from regions in Kansas, Oklahoma, and Texas. After a year of establishment we implemented a set of two-year water treatments that examined the responses in physiology, growth and development of switchgrass to predicted changes in precipitation amount for the central United States. After this experiment was completed we performed a second set of experiments that examined the responses of switchgrass physiology, growth, and development to changes in precipitation frequency. We also included in this analysis how genome size of individuals influenced their responses to precipitation frequency changes. Generally, we found switchgrass to be unresponsive to realistic predictions of precipitation changes for the Central Plains of the United States. These studies have provided significant insight into how this important grassland species will respond to future climate change from both an ecological and applied biological perspective. Finally, we provided insight into the mechanism through which this species changes in the face of altered water availability by not supporting the hypothesis that the control of switchgrass responses to changes in precipitation is altered by genome size. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center

  16. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Micahel P.; Springer, Clint J.

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  17. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael; Springer, Clint

    2014-06-18

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  18. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Michael P.; Springer, Clint J.

    2014-06-05

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  19. BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN EMPLOYEE OF REPUBLIC STEEL IN BUFFALO. BRASS STRIP FROM THE SLITTE IS USED ON THE BUFFALO PLANT'S CONTINUOUS SEAMLESS TUBE LINE. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  20. Perils of Accommodation: The Case of Joseph W. Holley

    ERIC Educational Resources Information Center

    O'Brien, Thomas V.

    2007-01-01

    This study examines accommodationism, a tactic of racial uplift used by black school founders and teachers in the Jim Crow South. For founders, accommodationism was a dangerous process of collaboration, resistance, and compromise. The subject under study is Joseph Winthrop Holley. Born in South Carolina, Holley studied in the North at Phillips…

  1. The Contributions of Joseph Sargent Hall to Appalachian Studies.

    ERIC Educational Resources Information Center

    Montgomery, Michael

    The work of Joseph Sargent Hall, a pioneer researcher in Appalachian studies, is chronicled. Hall was hired by the National Park Service in 1937, as a graduate student, to document the lives and lore of older mountain residents allowed to remain in the Great Smoky Mountains after the land was purchased for a national park. His early efforts…

  2. Pioneer in Behavioral Pharmacology: A Tribute to Joseph V. Brady

    ERIC Educational Resources Information Center

    Barrett, James E.

    2008-01-01

    The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner ("conditioned emotional response") procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group…

  3. 1. Historic American Buildings Survey Joseph Hill, Photographer March 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer March 10, 1936 CAST IRON BALCONY RAIL AND WROUGHT IRON WINDOW RAILING 945 NORTH DEARBORN STREET, CHICAGO - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  4. A Vignette of an American Sporting Sculptor: Joseph D. Brown.

    ERIC Educational Resources Information Center

    Field, David A.

    In this lecture, about sixty of the more important small and large sports sculptures and medals of Professor Joseph D. Brown are discussed and illustrated through the use of 35mm color slides. A brief description of the sculptor's life, interests, and philosophy of sport is also given. (MB)

  5. 75 FR 32742 - Action Affecting Export Privileges; Joseph Piquet

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ...: Joseph Piquet 76067-004 currently incarcerated at FDI Miami, Federal Detention Center, P.O. Box 019120... was convicted based on his role in a conspiracy to purchase high-tech military and dual-use electronic... involved in this conspiracy were high power amplifiers designed for use by the U.S. military in...

  6. Joseph Lancaster and the History of Reading Instruction.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Examining the origin and accomplishments of the Lancastrian monitorial system of instruction, this paper discusses the influence of that system on American education. It gives a brief history of how Joseph Lancaster became involved in reading instruction and how he was a pioneer in emphasizing a reading curriculum that was written down. It then…

  7. The Reaches of Conscience: An Interview with Joseph P. Lash.

    ERIC Educational Resources Information Center

    McCaffrey, Patrick

    1984-01-01

    Few people knew Eleanor Roosevelt as well as author Joseph P. Lash, author of the Pulitzer prize-winning "Eleanor and Franklin." In this interview Lash talks about Mrs. Roosevelt's personal characteristics, her educational theories, the role she played in attracting minorities to the Democratic Party, and FDR's influence on her. (RM)

  8. Joseph v. Brady: Synthesis Reunites What Analysis Has Divided

    ERIC Educational Resources Information Center

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found…

  9. Visions and Re-Visions of Charles Joseph Minard.

    ERIC Educational Resources Information Center

    Friendly, Michael

    2002-01-01

    Describes the contributions of Charles Joseph Minard to statistical graphics, noting the time course of his work and providing background on his famous effort, the flow-map depiction of Napoleon's march on Moscow. Explores some modern re-visions of this famous graphic from an information visualization perspective. (SLD)

  10. Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

    Cancer.gov

    Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

  11. Joseph Mallord William Turner: Burning of the Houses of Parliament.

    ERIC Educational Resources Information Center

    Solender, Katherine; Buchanan, Penelope D.

    1989-01-01

    Provides a lesson plan that introduces students in grades seven-nine to artistic depiction of a specific time and place. Explores Joseph Mallord William Turner's "Burning of the Houses of Parliament" as both visual record and emotional interpretation. Lists instructional strategies for description, analysis, interpretation, and judgment. Suggests…

  12. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    ERIC Educational Resources Information Center

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  13. Inside and outside: Boxes Inspired by Joseph Cornell

    ERIC Educational Resources Information Center

    Winters, Laurel

    2009-01-01

    In this article, the author describes an art project inspired by the work of Joseph Cornell. The project called for designing both the outside and the inside of a cigar box according to the student's theme. Thus, students needed to consider the viewer's vantage point with the box both closed and open, general design elements, two-dimensional and…

  14. Interview with Dr Joseph Murray (by Francis L Delmonico).

    PubMed

    Murray, Joseph

    2002-10-01

    The Editors asked Dr Delmonico to interview Dr Joseph Murray, winner of the Nobel prize in Medicine 1990 for performing the first successful renal transplant, to record recollections of the issues of the 1950s, when clinical transplantation was born, on Dr Murray's medical career in transplantation, and on some contemporary issues.

  15. Obituary: Joseph Wyan Chamberlain, 1928-2004

    NASA Astrophysics Data System (ADS)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  16. Obituary: Joseph Wyan Chamberlain, 1928-2004

    NASA Astrophysics Data System (ADS)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  17. Obituary: Richard Joseph Elston, 1960-2004

    NASA Astrophysics Data System (ADS)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  18. Shot noise displaying simultaneously the Noah and Joseph effects

    NASA Astrophysics Data System (ADS)

    Eliazar, Iddo; Klafter, Joseph

    2007-03-01

    Shot noise processes displaying the Noah effect are of infinite variance. Hence the measurement of the correlation structure of such processes—indicating whether the Joseph effect is displayed as well—cannot be conducted via their autocovariance functions (which are undefined). To circumvent this problem, a Poisson-based analysis applicable to shot noise processes with infinite variance, as well as to shot noise processes with divergent noise levels, is developed. A Poissonian autocovariance function, which characterizes the process-distribution of general shot noise processes, is introduced. In particular, this function governs and quantifies the processes’ stationary structure (amplitudal behavior) and correlation structure (temporal behavior). The “Poissonian methodology” developed enables a precise quantitative analysis of shot noise processes displaying simultaneously the Noah and Joseph effects.

  19. Photocopy of photograph (from NBPPNSY, CSF 4036766) Joseph P. Garfinkel, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (from NBP-PNSY, CSF 4036-7-66) Joseph P. Garfinkel, photographer, July 20, 1966 oblique aerial photo taken from an altitude of approximately 6,000 feet; view north of Philadelphia Naval Base and Shipyard. Reserve basin (Haer no. Pa-387-W) is at left center of photograph. - Naval Base Philadelphia-Philadelphia Naval Shipyard, League Island, Philadelphia, Philadelphia County, PA

  20. Joseph Rotblat, the bomb and anomalies from his archive.

    PubMed

    Underwood, Martin C

    2013-06-01

    Professor Sir Joseph Rotblat made significant contributions to nuclear physics and worked on the development of the atomic bomb. He walked out of the Manhattan Project after working there for less than a year, the only scientist to do so. Rotblat gave a comprehensive account of his time at Los Alamos. His Archive is now becoming available and papers contained therein are inconsistent with some aspects of his account. The reasons as to how such anomalies and contradictions could occur are considered.

  1. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  2. Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.

  3. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  4. Family dynamics in biblical times: Joseph as a family psychotherapist.

    PubMed

    Ben-Noun, Liubov Louba

    2003-06-01

    Families have existed for thousands of years and are the most enduring form of small social group. This article discusses the family of Jacob as described in the Bible, and analyses the dynamics of the family system, the relationships between family members and the ways in which they interact and respond to stressful events. Such events disrupted the equilibrium of the family and led to a severe crisis, but this was eventually resolved peacefully and family members were reconciled. The story of Joseph, Jacob's son, unfolds as possibly the earliest description of a psychotherapeutic intervention to resolve a long-standing family crisis.

  5. Joseph V. Brady: Synthesis Reunites What Analysis Has Divided

    PubMed Central

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922–2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found their way into designing environments for astronauts as well as studying drug effects on human social behavior in microenvironments. Brady created translational neurobehavioral science before such a concept existed. One of his most lasting contributions was developing a framework for ethical decision making to protect the rights of the people who participate in scientific research. PMID:23450040

  6. DCEG Symposium to Honor Joseph F. Fraumeni, Jr. | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer On May 6, the Division of Cancer Epidemiology and Genetics (DCEG) will sponsor a symposium to honor 50 years of leadership from its founding director, Joseph F. Fraumeni, Jr., M.D., who stepped down from the position in July 2012. The conference, entitled “Cancer Epidemiology: From Pedigrees to Populations,” will highlight critical findings in cancer epidemiology from the last 50 years, as well as opportunities for future research directions. Long History of Leadership and Discovery

  7. Joseph Harris of Trevecka: Scientist, Artisan, Servant of the Crown

    NASA Astrophysics Data System (ADS)

    Griffiths, M.

    2012-01-01

    A major goal of natural philosophy in the early eighteenth century was the search for accurate positional longitude. This quest demanded the most precise instruments and the most meticulous observations in astronomy and geophysics. Joseph Harris strode across these disciplines making a valuable contribution to the studies of astronomy, navigation, horology and magnetic variation. He later served his country by standardising weights and measures of coinage as Assay Master at the Royal Mint. Yet his prowess is little known or acknowledged. This paper describes and examines his life and roles.

  8. Internment and ministry: A dialogue with Joseph Kitagawa.

    PubMed

    Moss, D M

    1993-09-01

    This dialogue presents a profile of the late Joseph Kitagawa-a renowned scholar of the history of religions (Religionswissenschaft). It focuses on comparative religion and philosophy, as well as several other important issues related to his distinguished career as an Episcopal priest and dean of the Divinity School of the University of Chicago. They are: his experience of American concentration camps during World War II; Christian atheism and new theological models; concepts of time in Oriental and Occidental faiths; depth-psychology and contemporary ministry; and Paul Tillich's significance for the pastoral counseling movement.

  9. Professor Joseph Warren Horton (1889-1967): biological engineer.

    PubMed

    Zeitlin, Gerald L

    2005-02-01

    Joseph Warren Horton graduated with a degree in electrical engineering from the Massachusetts Institute of Technology (MIT) in 1914. He became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. In the mid-1930s he was appointed the first leader of the newly created Department of Biological Engineering at MIT and in this position he made major contributions to the application of physics to human physiology, in particular by increasing the safety of explosive inhalational anaesthetic agents.

  10. Joseph Rotblat, the bomb and anomalies from his archive.

    PubMed

    Underwood, Martin C

    2013-06-01

    Professor Sir Joseph Rotblat made significant contributions to nuclear physics and worked on the development of the atomic bomb. He walked out of the Manhattan Project after working there for less than a year, the only scientist to do so. Rotblat gave a comprehensive account of his time at Los Alamos. His Archive is now becoming available and papers contained therein are inconsistent with some aspects of his account. The reasons as to how such anomalies and contradictions could occur are considered. PMID:22190230

  11. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  12. 77 FR 3797 - Joseph Deluca, D.O.; Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Joseph Deluca, D.O.; Dismissal of Proceeding On July 16, 2010, the Deputy Assistant... Joseph Deluca, D.O. (Registrant), of Coral Springs, Florida. The Show Cause Order proposed the...

  13. Leader and Spokesman for a People in Exile: Chief Joseph and the Nez Perce

    ERIC Educational Resources Information Center

    Jain, Samvit

    2009-01-01

    This article discusses Chief Joseph's surrender that marked the beginning of his diplomatic stand for justice in Indian Territory, where his tribe was forcibly exiled in accordance with American Indian policy of the time. Joseph battled for the repatriation of the Nez Perce through protests and other legal means, winning the support of the growing…

  14. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    ERIC Educational Resources Information Center

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl Jung was…

  15. Joseph Rotblat: Moral Dilemmas and the Manhattan Project

    NASA Astrophysics Data System (ADS)

    Veys, Lucy

    2013-12-01

    John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.

  16. Joseph Rotblat and the moral responsibilities of the scientist.

    PubMed

    Underwood, Martin Clifford

    2009-06-01

    Professor Sir Joseph Rotblat was one of the most distinguished scientists and peace campaigners of the post second world war period. He made significant contributions to nuclear physics and worked on the development of the atomic bomb. He then became one of the world's leading researchers into the biological effects of radiation. His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and peace. For this he was awarded the Nobel Peace Prize, together with Pugwash Conferences on Science and World Affairs (that he helped found) in 1995. His work in this area ranked with that of Albert Einstein and Bertrand Russell and this article is an attempt to summarise his life, achievements, but in particular outline his views on the moral responsibilities of the scientist. He is a towering intellectual figure and his contributions to mankind should be better known and more widely understood.

  17. Constructing Joseph Fredericks: competing narratives of a child sex murderer.

    PubMed

    Petrunik, Michael; Weisman, Richard

    2005-01-01

    Joseph Fredericks--one of Canada's most notorious sex offenders--was defined through the institutions that dealt with him from his infancy to his death to the inquest held after his death. In this paper, we locate in historical context and compare the different narratives that were constructed of his life in each of these institutional settings from unwanted child to 'mental defective' to psychiatric offender to criminal recidivist to victim to iconic sexual predator. We show that each of these narratives claimed to capture the essence of Fredericks in terms of what were his core characteristics and what remedies were necessary for the problems he posed only to be superseded by new narratives based on different assumptions. Finally, we show how one of these conceptions of Frederick's essence influenced a shift in Canadian public policy for sex offenders toward the greater emphasis on community protection characteristic of public policy in the United States. PMID:15710450

  18. Pierre-Joseph Macquer: Chemistry in the French Enlightenment.

    PubMed

    Lehman, Christine

    2014-01-01

    Despite recent studies of chemistry courses and of academic research at the beginning of the eighteenth century, the perception of chemistry in the French Enlightenment has often been overshadowed by Lavoisier's works. This article proposes three specific case studies selected from Pierre Joseph Macquer's (1718-84) rich career to show the continuous evolution of chemistry throughout the century: medicinal chemistry through the application of the Comte de La Garaye's metallic salt solutions, the emergence of industrial chemistry through a few of Macquer's evaluations at the Bureau du Commerce, and finally communal academic research through the experiments on diamonds using Tschirnhaus's lens. These examples attempt to illustrate the innovative, creative, dynamic, multicultural, and multifaceted chemistry of the Enlightenment. PMID:26103758

  19. Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "WAHT A GOVERNMENT CANAL AND AN ASSURED WATER SUPPLY WILL DO IN A DESERT AREA IS SHOWN IN THIS AIR VIEW OF A SECTION OF THE YAKIMA FEDERAL RECLAMATION PROJECT IN CENTRAL WASHINGTON. THE MAIN CANAL IS SEEN RUNNING DOWN THE MIDDLE OF THE VALLEY WITH PATCHES OF ORCHARDS AND FIELDS ON EITHER SIDE, BUT ABOVE THE CANAL LINE THE SAGE BRUSH DESERT REMAINS, AS CAN BE SEEN ON THE LEFT. THE YAKIMA PROJECT SUPPORTS MORE THAN 110,000 PEOPLE IN A TERRITORY WHICH WAS DESERT 35 YEARS AGO. MANY OF THE ORIGINAL SETTLERS WHO CAME, LIKE THOSE WHO ARE NOW SETTLING ON THE VALE PROJECT, TO BREAK THE RAW DESERT LAND, ARE STILL LIVING ON THESE NEATLY CHECKERBOARDED FARMS" - Kachess Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

  20. Joseph Lister and the performance of antiseptic surgery

    PubMed Central

    Worboys, Michael

    2013-01-01

    This article highlights a neglected feature of Joseph Lister's work, namely how, in addition to promoting germ theories and the principles of the antiseptic system, he also devoted much time and effort to communicating the performative aspects of antisepsis and of the many other surgical innovations that he developed. Attention to ‘detail’ and striving for ‘improvement’ were crucial to Listerian practice, and he sought to convey his credo in three main ways: first, his publications aimed at ‘bringing the subject out in the same sort of way as it had been worked out by himself’; second, he set out strict protocols and information on materials and methods, yet also encouraged surgeons to improvise; and third, he made himself an exemplar of a new form of professionalism, which made constancy and vigilance in practice a moral duty for surgeons. PMID:24686323

  1. Neurology and surrealism: André Breton and Joseph Babinski.

    PubMed

    Haan, Joost; Koehler, Peter J; Bogousslavsky, Julien

    2012-12-01

    Before he became the initiator of the surrealist movement, André Breton (1896-1966) studied medicine and worked as a student in several hospitals and as a stretcher bearer at the front during World War I. There he became interested in psychiatric diseases such as hysteria and psychosis, which later served as a source of inspiration for his surrealist writings and thoughts, in particular on automatic writing. Breton worked under Joseph Babinski at La Pitié, nearby La Salpêtrière, and became impressed by the 'sacred fever' of the famous neurologist. In this article, we describe the relationship between Breton and Babinski and try to trace back whether not only Breton's psychiatric, but also his neurological experiences, have influenced surrealism. We hypothesize that Breton left medicine in 1920 partly as a consequence of his stay with Babinski. PMID:22685227

  2. Joseph Lister: his contributions to early experimental physiology

    PubMed Central

    Howard, Edward R.

    2013-01-01

    Joseph Lister (1827–1912) acquired a lifelong interest in histology and experimental physiology while a student at University College London between 1848 and 1852. His first two publications in 1853 were histological studies of the contractile tissue of the iris and the skin. Studies of inflammation in 1855 progressed to experiments on the nervous control of arteries, using techniques of peripheral nerve division, spinal cord section and needle stimulation of the brain. This interest in nervous mechanisms led to innovative experiments on gut motility and the autonomic nervous system, from which he inferred that sympathetic nerve control was mediated via intrinsic neuronal plexuses in the gut wall, a mode of action confirmed 100 years later, in 1964–65. It is not generally known that Lister was elected FRS for this early experimental work and that his early commitment to experimental science and microscopy was the background to his later work on the development of surgical antisepsis.

  3. Joseph Gurney Barclay and the 1860 10-inch Cooke refractor

    NASA Astrophysics Data System (ADS)

    Barclay, C. E.

    2006-12-01

    Joseph Gurney Barclay (1816-1898) was a partner in the banking firm of Barclay, Bevan & Co. He was, like his grandfather, Robert Barclay of Clapham, a keen Astronomer who observed regularly at his home Knotts Green House in Leyton, Essex, England, and he was a frequent contributor to the Monthly Notices of the Royal Astronomical Society. Employing professional astronomers, he made many original observations, especially following the acquisition of a 10-inch Cooke refractor in 1860. Gifted to the Radcliffe Observatory, Oxford in 1885, the 'Barclay Equatorial' continued in professional use until 1935 when it was removed to Marlborough College in Wiltshire, England, where it is now in full computerized use following complete restoration.

  4. Pierre-Joseph Macquer: Chemistry in the French Enlightenment.

    PubMed

    Lehman, Christine

    2014-01-01

    Despite recent studies of chemistry courses and of academic research at the beginning of the eighteenth century, the perception of chemistry in the French Enlightenment has often been overshadowed by Lavoisier's works. This article proposes three specific case studies selected from Pierre Joseph Macquer's (1718-84) rich career to show the continuous evolution of chemistry throughout the century: medicinal chemistry through the application of the Comte de La Garaye's metallic salt solutions, the emergence of industrial chemistry through a few of Macquer's evaluations at the Bureau du Commerce, and finally communal academic research through the experiments on diamonds using Tschirnhaus's lens. These examples attempt to illustrate the innovative, creative, dynamic, multicultural, and multifaceted chemistry of the Enlightenment.

  5. Science Advisor and Applied Physicist: Joseph Henry Serves His Country

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    1997-04-01

    When Joseph Henry accepted the postion of secretary of the Smithsonian in 1846, his career changed radically. Although he never ceased thinking of himself as a research scientist and educator, thereafter his chief roles were those of science administrator and advisor to both the executive and legislative branches of the federal government for both science and technology. His effectiveness as an advocate became more important than his skill as an experimental physicist. Even when he entered the laboratory, his role had changed. No longer was he concerned with basic research. As a member of various government boards and committees, Henry spent the last three decades of his life concerned with the application of fundamental knowledge for the improvement of the human condition. This paper will discuss Henry's service on behalf of his country.

  6. Joseph Rotblat and the moral responsibilities of the scientist.

    PubMed

    Underwood, Martin Clifford

    2009-06-01

    Professor Sir Joseph Rotblat was one of the most distinguished scientists and peace campaigners of the post second world war period. He made significant contributions to nuclear physics and worked on the development of the atomic bomb. He then became one of the world's leading researchers into the biological effects of radiation. His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and peace. For this he was awarded the Nobel Peace Prize, together with Pugwash Conferences on Science and World Affairs (that he helped found) in 1995. His work in this area ranked with that of Albert Einstein and Bertrand Russell and this article is an attempt to summarise his life, achievements, but in particular outline his views on the moral responsibilities of the scientist. He is a towering intellectual figure and his contributions to mankind should be better known and more widely understood. PMID:19247813

  7. Joseph's Story: A Case Study of Late-Onset Necrotizing Enterocolitis From Early Birth to Recovery.

    PubMed

    Gephart, Sheila M; Martin, Laura B; Kijewski, Amy; Johnson, Scott R

    2015-01-01

    Although necrotizing enterocolitis (NEC) is often catastrophic among premature infants, most cases occur in the first month after birth. This case study presents Joseph's story about a 24-week surviving twin who developed severe NEC at 5 months of age just days before he was to go home. The purpose of this case study report is to place Joseph and his parents' experience in the context of what is known about NEC risk factors, clinical presentation, and treatment, and then to offer recommendations to healthcare professionals to support families from NEC diagnosis to recovery. Now 5 years old, Joseph continues to manage consequences of NEC including deafness, developmental delay, multiple food allergies, and recurrent gastrointestinal challenges from short gut syndrome. Although NEC struck late and kept Joseph in the neonatal intensive care unit for 228 days, its consequences remain with this resilient child and his family. PMID:26505849

  8. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    SciTech Connect

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  9. 1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, 1936 (Copied from small photo taken by survey members) OLD APARTMENT HOUSE - Jansonist Colony, Old Apartment House, Main Street, Bishop Hill, Henry County, IL

  10. School Public Relations and the Principalship: An Interview with Joseph Murphy.

    ERIC Educational Resources Information Center

    Sweetland, Scott R.; Cybulski, Timonty G.

    2002-01-01

    Interview with Joseph Murphy, professor and head of the Ohio Principals Leadership Academy at The Ohio State University. Murphy answers questions about principal leadership, administrator preparation, and school public relations. (PKP)

  11. The way of sex: Joseph Needham and Jolan Chang.

    PubMed

    Rocha, Leon Antonio

    2012-09-01

    This paper analyses the understandings of Daoist alchemy and Chinese sexuality of Joseph Needham and his friend and correspondent, the Chinese-Swedish writer Jolan Chang (Chang Chung-lan, 1917-2002). Using the extensive correspondence between the two men, as well as Needham's files on "inner alchemy" deposited at the Needham Research Institute, the paper begins with a partial reconstruction of a 1977 symposium, chaired by Needham, to promote Chang's new book, The Tao of Love and Sex: The Ancient Chinese Way to Ecstasy. Needham and Chang's visions of Chinese sex are then read against excerpts from Science and Civilisation in China, specifically Volume V: Chemistry and Chemical Technology, Part 5: Spagyrical Discovery and Invention: Physiological Alchemy (1983). Three inter-related aspects are explored. First, reading Science and Civilisation in China against materials in the Needham archives offers crucial hints to Needham's historiography and historical practice. Second, the way that Daoist regimens came to be actively reconstructed and repackaged as practices concerned with the enhancement of sexual pleasure and intensity. Third, the investigation of the networks and circulations of assumptions, visions, fantasies about "China".

  12. The way of sex: Joseph Needham and Jolan Chang.

    PubMed

    Rocha, Leon Antonio

    2012-09-01

    This paper analyses the understandings of Daoist alchemy and Chinese sexuality of Joseph Needham and his friend and correspondent, the Chinese-Swedish writer Jolan Chang (Chang Chung-lan, 1917-2002). Using the extensive correspondence between the two men, as well as Needham's files on "inner alchemy" deposited at the Needham Research Institute, the paper begins with a partial reconstruction of a 1977 symposium, chaired by Needham, to promote Chang's new book, The Tao of Love and Sex: The Ancient Chinese Way to Ecstasy. Needham and Chang's visions of Chinese sex are then read against excerpts from Science and Civilisation in China, specifically Volume V: Chemistry and Chemical Technology, Part 5: Spagyrical Discovery and Invention: Physiological Alchemy (1983). Three inter-related aspects are explored. First, reading Science and Civilisation in China against materials in the Needham archives offers crucial hints to Needham's historiography and historical practice. Second, the way that Daoist regimens came to be actively reconstructed and repackaged as practices concerned with the enhancement of sexual pleasure and intensity. Third, the investigation of the networks and circulations of assumptions, visions, fantasies about "China". PMID:22652507

  13. Moths on the Flatbed Scanner: The Art of Joseph Scheer.

    PubMed

    Buchmann, Stephen L

    2011-01-01

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale. PMID:26467835

  14. Electrical Enlightenment: Joseph Priestley's Historical and Experimental Studies of Electricity

    NASA Astrophysics Data System (ADS)

    Boantza, Victor

    Joseph Priestley (1733-1804) was one of the most controversial public figures of the eighteenth century. A true Enlightenment polymath, he wrote more than two hundred books, pamphlets, sermons, and essays on subjects ranging from science to politics and from metaphysics to theology. He was a religious dissenter, political radical, vocal supporter of the French Revolution, and lifelong defender of the losing side in the Chemical Revolution. Priestley is best known for having ``discovered'' oxygen in the 1770s and for his lasting contributions to pneumatic chemistry. Yet his first scientific fascination, while teaching at Warrington Academy, was electricity--one of the greatest scientific fads of the Enlightenment. Priestley's work on electricity, both historical and experimental, culminated in his History and Present State of Electricity (1767), which became a standard textbook on the subject for nearly a century, and went through numerous editions and translations. Situating Priestley's electrical investigations against the background of eighteenth-century ideals of scientific theory and practice, especially concerning physics, experimental philosophy, and natural history, illuminates the relations between science, society, and epistemology in the Enlightenment.

  15. Moths on the Flatbed Scanner: The Art of Joseph Scheer

    PubMed Central

    Buchmann, Stephen L.

    2011-01-01

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale. PMID:26467835

  16. Franz Joseph Gall and music: the faculty and the bump.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. PMID:25684283

  17. Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

    PubMed Central

    Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira

    2016-01-01

    Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the ATXN3 gene. This expansion translates into a polyglutamine tract within the ataxin-3 protein that confers a toxic gain-of-function to the mutant protein ataxin-3, contributing to protein misfolding and intracellular accumulation of aggregates and neuronal degeneration. Autophagy impairment has been shown to be one of the mechanisms that contribute for the MJD phenotype. Here we investigated whether this phenotype was present in patient-derived fibroblasts, a common somatic cell type used in the derivation of induced pluripotent stem cells and subsequent differentiation into neurons, for in vitro disease modeling. We generated and studied adult dermal fibroblasts from 5 MJD patients and 4 healthy individuals and we found that early passage MJD fibroblasts exhibited autophagy impairment with an underlying mechanism of decreased autophagosome production. The overexpression of beclin-1 on MJD fibroblasts reverted partially autophagy impairment by increasing the autophagic flux but failed to increase the levels of autophagosome production. Overall, our results provide a well-characterized MJD fibroblast resource for neurodegenerative disease research and contribute for the understanding of mutant ataxin-3 biology and its molecular consequences. PMID:27328712

  18. Franz Joseph Gall and music: the faculty and the bump.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking.

  19. Joseph Barcroft's studies of high-altitude physiology.

    PubMed

    West, John B

    2013-10-15

    Joseph Barcroft (1872-1947) was an eminent British physiologist who made contributions to many areas. Some of his studies at high altitude and related topics are reviewed here. In a remarkable experiment he spent 6 days in a small sealed room while the oxygen concentration of the air gradually fell, simulating an ascent to an altitude of nearly 5,500 m. The study was prompted by earlier reports by J. S. Haldane that the lung secreted oxygen at high altitude. Barcroft tested this by having blood removed from an exposed radial artery during both rest and exercise. No evidence for oxygen secretion was found, and the combination of 6 days incarceration and the loss of an artery was heroic. To obtain more data, Barcroft organized an expedition to Cerro de Pasco, Peru, altitude 4,300 m, that included investigators from both Cambridge, UK and Harvard. Again oxygen secretion was ruled out. The protocol included neuropsychometric measurements, and Barcroft famously concluded that all dwellers at high altitude are persons of impaired physical and mental powers, an assertion that has been hotly debated. Another colorful experiment in a low-pressure chamber involved reducing the pressure below that at the summit of Mt. Everest but giving the subjects 100% oxygen to breathe while exercising as a climber would on Everest. The conclusion was that it would be possible to reach the summit while breathing 100% oxygen. Barcroft was exceptional for his self-experimentation under hazardous conditions.

  20. Notes on Joseph Fraunhofer's honorary Ph.D. degree from Erlangen, 1822 (German Title: Bemerkungen zur Ehrenpromotion Joseph Fraunhofers 1822 in Erlangen )

    NASA Astrophysics Data System (ADS)

    Ventzke, Karl

    In 1822, Joseph Fraunhofer received a honorary Ph.D. degree from Erlangen University. Presumably, this distinction was based on suggestions by Johann Wilhelm Pfaff. Since 1822, Pfaff gave lectures with the inclusion of instruments, which he obtained directly from Fraunhofer, and presumably also included problems of spectral investigation. This contribution analyzes informations which were collected in this regard.

  1. Oral Histories in Meteoritics and Planetary Science - XVII: Joseph Goldstein

    NASA Astrophysics Data System (ADS)

    Sears, Derek W. G.

    2012-05-01

    In this interview, Joseph Goldstein (Fig. 1) recounts how he became interested in meteorites during his graduate studies working with Robert Ogilvie at MIT. By matching the Ni profiles observed across taenite fields in the Widmanstätten structure of iron meteorites with profiles he computed numerically he was able to determine cooling rates as the meteorites cooled through 650-400 °C. Upon graduating, he worked with a team of meteorite researchers led by Lou Walter at Goddard Space Flight Center where for 4 years he attempted to understand metallographic structures by reproducing them in the laboratory. Preferring an academic environment, Joe accepted a faculty position in the rapidly expanding metallurgy department at Lehigh University where he was responsible for their new electron microprobe. He soon became involved in studying the metal from lunar soils and identifying the metallic component from its characteristic iron and nickel compositions. Over the next two decades he refined these studies of Ni diffusion in iron meteorites, particularly the effect of phosphorus in the process, which resulted in superior Fe-Ni-P phase diagrams and improved cooling rates for the iron meteorites. After a period as vice president for research at Lehigh, in 1993 he moved to the University of Massachusetts to serve as dean of engineering, but during these administrative appointments Joe produced a steady stream of scientific results. Joe has served as Councilor, Treasurer, Vice President, and President of the Meteoritical Society. He received the Leonard Medal in 2005, the Sorby Award in 1999, and the Dumcumb Award for in 2008.

  2. Machado-Joseph Disease: from first descriptions to new perspectives

    PubMed Central

    2011-01-01

    Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represents the most common form of SCA worldwide. MJD is an autosomal dominant neurodegenerative disorder of late onset, involving predominantly the cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems; although sharing features with other SCAs, the identification of minor, but more specific signs, facilitates its differential diagnosis. MJD presents strong phenotypic heterogeneity, which has justified the classification of patients into three main clinical types. Main pathological lesions are observed in the spinocerebellar system, as well as in the cerebellar dentate nucleus. MJD's causative mutation consists in an expansion of an unstable CAG tract in exon 10 of the ATXN3 gene, located at 14q32.1. Haplotype-based studies have suggested that two main founder mutations may explain the present global distribution of the disease; the ancestral haplotype is of Asian origin, and has an estimated age of around 5,800 years, while the second mutational event has occurred about 1,400 years ago. The ATXN3 gene encodes for ataxin-3, which is ubiquitously expressed in neuronal and non-neuronal tissues, and, among other functions, is thought to participate in cellular protein quality control pathways. Mutated ATXN3 alleles consensually present about 61 to 87 CAG repeats, resulting in an expanded polyglutamine tract in ataxin-3. This altered protein gains a neurotoxic function, through yet unclear mechanisms. Clinical variability of MJD is only partially explained by the size of the CAG tract, which leaves a residual variance that should be explained by still unknown additional factors. Several genetic tests are available for MJD, and Genetic Counseling Programs have been created to better assist the affected families, namely on what concerns the possibility of pre-symptomatic testing. The main goal of this review was to bring together updated knowledge on MJD, covering

  3. Cytokines in Machado Joseph Disease/Spinocerebellar Ataxia 3.

    PubMed

    da Silva Carvalho, Gerson; Saute, Jonas Alex Morales; Haas, Clarissa Branco; Torrez, Vitor Rocco; Brochier, Andressa Wigner; Souza, Gabriele Nunes; Furtado, Gabriel Vasata; Gheno, Tailise; Russo, Aline; Monte, Thais Lampert; Schumacher-Schuh, Artur; D'Avila, Rui; Donis, Karina Carvalho; Castilhos, Raphael Machado; Souza, Diogo Onofre; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Camey, Suzi; Portela, Luis Valmor; Jardim, Laura Bannach

    2016-08-01

    The aim of the present study is to describe the serum concentrations of a broad spectrum of cytokines in symptomatic and asymptomatic carriers of Machado Joseph disease (SCA3/MJD) CAG expansions. Molecularly confirmed carriers and controls were studied. Age at onset, disease duration, and clinical scales Scale for the Assessment and Rating of Ataxia (SARA), Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), SCA Functional Index (SCAFI), and Composite Cerebellar Functional Score (CCFS) were obtained from the symptomatic carriers. Serum was obtained from all individuals and a cytokine panel "consisted of" eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, monokine induced by gamma interferon (MIG), macrophage inflammatory protein (MIP)-a, MIP-b, regulated on activation, normal T cell expressed and secreted (RANTES) and tumor necrosis factor (TNF)-α was analyzed. In a subgroup of symptomatic carriers, the cytokine panel was repeated after 360 days. Cytokine distribution among groups was studied by discriminant analysis; changes in serum levels after 360 days were studied by generalized estimation equation. Sixty-six symptomatic carriers, 13 asymptomatic carriers, and 43 controls were studied. No differences in cytokine patterns were found between controls and carriers of the CAG expansions or between controls and symptomatic carriers only. In contrast, eotaxin concentrations were significantly higher in asymptomatic than in symptomatic carriers or in controls (p = 0.001, ANCOVA). Eotaxin did not correlate with age, disease duration, CAG expansion, NESSCA score, and SARA score. Among symptomatic carriers, eotaxin dropped after 360 days (p = 0.039, GEE). SCA3/MJD patients presented a benign pattern of

  4. Sister Mary Joseph Nodules on 99mTc HYNIC-TOC scintigraphy in patients with neuroendocrine tumors.

    PubMed

    Jing, Hongli; Zhang, Yingqiang; Li, Fang

    2015-02-01

    A Sister Mary Joseph nodule represents an umbilical metastasis, which is more commonly caused by a primary malignancy in gastrointestinal tract or from reproductive system. We report Sister Mary Joseph nodules caused by neuroendocrine tumor and revealed on Tc HYNIC-TOC scintigraphy.

  5. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  6. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  7. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    PubMed

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  8. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    PubMed

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  9. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  10. 75 FR 63801 - Action Affecting Export Privileges; Joseph Piquet and Related Person Alphatronx, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... individual Joseph Piquet (``Piquet'') on May 28, 2010 (75 FR 32742, June 9, 2010) applicable to Alphatronx... August 12, 2010 (75 FR 50,681 (Aug. 16, 2010)), has continued the Regulations in effect under the... published in the Federal Register on June 9, 2010 at 75 FR 32742, shall be made applicable to...

  11. Joseph Walker, a Black Playwright, Exhorts Counselors and Black People to Deal With Themselves

    ERIC Educational Resources Information Center

    Walker, Joseph

    1976-01-01

    This is an interview with Joseph Walker, black playwright. He attempts to reflect back to the black community their experience in a white controlled world. In this interview, he discusses his views of the black experience, the pressures on man-woman relationships, and the role of black psychiatry. (NG)

  12. Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2009-01-01

    This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

  13. Factors Influencing Nutrient Losses from Agriculture in the St. Joseph River Watershed, Northeast Indiana

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Nutrient losses from agricultural watersheds in Indiana have been implicated in the hypoxic zone in the Gulf of Mexico as well as massive algal blooms in Lake Erie. We monitored water quality from fields and drainage ditches in the St. Joseph River Watershed, Northeast Indiana. The complex ‘pot-ho...

  14. Standards for Upper-Division Colleges, With Special Reference to Joplin and St. Joseph, Missouri.

    ERIC Educational Resources Information Center

    Browne, Richard G.

    In 1965, the legislature of the State of Missouri enacted a bill which provided for the establishment of upper-division programs at the Jasper County (Missouri Southern) and St. Joseph (Missouri Western) Junior Colleges. Under the same bill, the Board of Curators of Missouri University was charged with setting standards to determine the adequacy…

  15. From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2010-01-01

    This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…

  16. 78 FR 66801 - Norfolk Southern Railway Company-Abandonment Exemption-in St. Joseph County, Ind.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in St. Joseph County... 1152 subpart F-Exempt Abandonments to abandon a total of approximately 1.5 miles of rail line located... exemption, any employee adversely affected by the abandonment shall be protected under Oregon Short...

  17. 75 FR 73135 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... licensee), for operation of the Joseph M. Farley Nuclear Plant, Units 1 and 2 (FNP), located in Houston... the FNP from the required implementation date of March 31, 2010, for several new requirements of 10 CFR Part 73. Specifically, FNP would be granted an exemption from being in full compliance...

  18. What's in a Coauthor?: (Re)Locating Joseph Denney in Composition History

    ERIC Educational Resources Information Center

    Davis, Ivan

    2012-01-01

    This article reassesses the Fred Newton Scott and Joseph Villiers Denney collaborative textbook authorship by emphasizing Denney's generally overlooked contributions to that coauthorship and to the field of composition generally. Through an examination of Denney's scholarly work and his personal correspondence with Scott during the period marking…

  19. Conceiving of Concept Maps to Foster Meaningful Learning: An Interview with Joseph D. Novak

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2004-01-01

    Joseph Novak discusses the concept of mapping to capture and archive expert knowledge. He worked in various corporations where he used the concept of mapping for research and development efforts and to create and transfer knowledge and information in corporate environments.

  20. Joseph Woolley--Pioneer of British Naval Education; 1848-1879

    ERIC Educational Resources Information Center

    Dickinson, H. W.

    2007-01-01

    For almost 25 years Joseph Woolley served the Admiralty as a teacher, inspector of schools and as the first Admiralty Director of Education. Despite the fact that Woolley held this post for a decade, that he was the sole occupant in the nineteenth century and that in this capacity he gave evidence to, or was a member of, every government committee…

  1. Highlighting High Performance Buildings: Adam Joseph Lewis Center for Environmental Studies

    SciTech Connect

    2002-11-01

    Oberlin College's Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.

  2. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    ERIC Educational Resources Information Center

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of advertising…

  3. Plight of the Chicago Schools: A Profile of and Interview with the New Superintendent Joseph Hannan.

    ERIC Educational Resources Information Center

    Ogletree, Earl J.

    This paper presents a profile of and an interview with the new superintendent of the Chicago Public Schools, Joseph Hannan. The problems confronting the new superintendent are the same as those faced by the previous superintendent except for the decrease in school enrollment and a financial crisis stemming from a depressed economy. Hannan views…

  4. The Joseph Bellamy House: Great Awakening in Puritan New England. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Pape, Barbara Bradbury

    The small rural town of Bethlehem, Connecticut, contains pristine examples of modest 18th-century houses that surround a charming village green. Opposite the village green, the Reverend Joseph Bellamy's immense white clapboard house rises from a hilltop, an imposing presence that makes the village appear diminutive. The house stands today as a…

  5. Constructing Secret Rooms: Assemblages, Creative Writing, Self-discovery, and the Art of Joseph Cornell.

    ERIC Educational Resources Information Center

    Platt, Thomas Julian

    1998-01-01

    Profiles a course that challenges college seniors to gain new perspectives, skills, experiences, and insights into their own creative and imaginative processes. The course uses the work of Joseph Cornell who constructed enigmatic, box-like assemblages from found objects. Students construct their own boxes and consider future applications of this…

  6. Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma.

    PubMed

    Kirshtein, Boris; Meirovitz, Mihai; Okon, Elimelech; Piura, Benjamin

    2006-01-01

    Umbilical metastasis (Sister Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of Sister Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, Sister Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of Sister Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.

  7. Painting as Rhetorical Performance: Joseph Wright's "An Experiment on a Bird in the Air Pump."

    ERIC Educational Resources Information Center

    Helmers, Marguerite

    2001-01-01

    Explores three broad areas of inquiry: what significance visual images have for rhetorical analysis; how a study of nonverbal material might be conducted; and whether visual explanations depend on the image or the viewer. Argues that viewers understand Joseph Wright's painting "The Air Pump" in terms of its subject, its exhibition space, the…

  8. Astronauts Joseph Allen rides cherry picker over stowage area/work station

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Joseph P. Allen rides a cherry picker over to a stowage area/work station to wrap up extravehicular activity (EVA) duties above Earth. The cherry picker is a union of the mobile foot restraint and the remote manipulator system (RMS), controlled from inside Discovery's cabin. The Westar VI/PAM-D satellite is pictured secured in Discovery's cargo bay.

  9. Toward a Telic Vision of Human Beings: A Dialogue with Joseph F. Rychlak.

    ERIC Educational Resources Information Center

    Howard, George S.

    1987-01-01

    Presents interview with Joseph F. Rychlak on topics of notions of causality in science, relationship of research to practice in humanistic psychology, research evidence for a telic view of human action, counseling active agents, choice and free will, and philosophy of science and humanisitic theory. (ABL)

  10. Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution

    ERIC Educational Resources Information Center

    Clay, Richard

    2008-01-01

    This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…

  11. Recent theoretical chemical dynamics at Rochester in the paths of Joseph O. Hirschfelder

    NASA Technical Reports Server (NTRS)

    George, T. F.; Lam, K.-S.; Bhattacharyya, D. K.; Hutchinson, M.; Zimmerman, I. H.; Devries, P. L.; Yuan, J.-M.

    1982-01-01

    A review of recent theoretical studies of gas-phase molecular rate processes, including various effects of laser radiation, is presented in the context of the extensive and influential work of Joseph O. Hirschfelder during the past half-century. The topics addressed are energy transfer, chemical reactions, unimolecular dissociation, transition states, and bound-continuum interactions.

  12. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    ERIC Educational Resources Information Center

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  13. The Oral History of Evaluation: The Professional Development of Joseph Wholey

    ERIC Educational Resources Information Center

    Miller, Robin Lin; Caracelli, Valerie

    2013-01-01

    Joseph S. Wholey is Professor Emeritus in the University of Southern California's (USC) School of Public Policy, Planning, and Development. He received his BA from Catholic University, Phi Beta Kappa and his MA in mathematics and PhD in philosophy from Harvard University. His work focuses on the use of strategic planning, performance measurement,…

  14. Styles of Halakhic Ruling: A Mapping in Light of Joseph Schwab's Philosophy of Education

    ERIC Educational Resources Information Center

    Rosenak, Avinoam

    2007-01-01

    This article notes a profound connection between the philosophy of Jewish law (halakhah) and the research of meta-halakah on the one hand and the philosophy of education on the other hand. The connection is, in principle, exemplified through an encounter between the educational philosophy of Joseph Schwab and the Jewish law (halakhic responsa…

  15. Psi Chi/APA Edwin B. Newman Graduate Research Award: Joseph H. Hammer

    ERIC Educational Resources Information Center

    American Psychologist, 2009

    2009-01-01

    Joseph H. Hammer, recipient of the Psi Chi/APA Edwin B. Newman Graduate Research Award, is cited for an outstanding research paper whose findings provide important evidence regarding the promise of a male-sensitive approach to mental health marketing and empirically support the inclusion of theory-driven enhancements in group-targeted mental…

  16. An Assessment of the Importance of Joseph Mayer Rice in American Educational Research.

    ERIC Educational Resources Information Center

    Banerji, Madhabi

    Historical accounts of the American public school system vary on whether Joseph Mayer Rice, the 19th century physician-turned-journalist who wrote numerous studies aimed at educational reform, is important in the history of educational research and on the nature of his influence in the field. An examination of the treatment of Rice by educational…

  17. General Education Assessment and Fulfilling the Mercy Mission at the University of Saint Joseph

    ERIC Educational Resources Information Center

    Callahan, Kevin J.

    2014-01-01

    This article describes the processes and procedures the University of Saint Joseph used to conduct a systematic assessment of mission-related student-learning outcomes found in the General Education curriculum, and thus assess how well the institution was fulfilling its Mercy mission. The assessment showed student learning strengths and gaps and…

  18. Joseph Ames's "Typographical Antiquities" and the Antiquarian Tradition

    ERIC Educational Resources Information Center

    Shiner, Elaine

    2013-01-01

    One of the most famous historical documents of English printing is Joseph Ames's "Typographical Antiquities," published in London in 1749. Although Ames referred to his work as a history of printing, the bulk of it is a list of the first printers in England and their works through 1600, with very full bibliographical descriptions…

  19. A Curriculum for Character Education: Joseph Schwab and the Ramah Camps

    ERIC Educational Resources Information Center

    Cohen, Burton; Pereira, Peter; Roby, Thomas; Block, Alan

    2005-01-01

    Joseph Schwab (1909-1988) is known for his scathing critique of curriculum theory and its over reliance on quantitative models derived from social science theories. From the late 1950's through the middle 1960's, Schwab was instrumental to efforts to create a new and more educationally sound curriculum for weekday religious schools in synagogues…

  20. On "Literature Reviews of, and for, Educational Research": A Response to the Critique by Joseph Maxwell

    ERIC Educational Resources Information Center

    Boote, David N.; Beile, Penny

    2006-01-01

    This article is a response to the critique by Joseph Maxwell on the article written by these authors entitled "Scholars Before Researchers: On the Centrality of the Dissertation Literature Review in Research Preparation". Maxwell argues that dissertations should emulate research articles and include a conceptual framework that only discusses…

  1. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.

    PubMed

    Mendonça, Liliana S; Nóbrega, Clévio; Hirai, Hirokazu; Kaspar, Brian K; Pereira de Almeida, Luís

    2015-02-01

    Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments such as gait ataxia, associated with multiple neuropathological changes including mutant ATXN3 inclusions, marked neuronal loss and atrophy of the cerebellum. Thus, an effective treatment of symptomatic patients with Machado-Joseph disease may require cell replacement, which we investigated in this study. For this purpose, we injected cerebellar neural stem cells into the cerebellum of adult Machado-Joseph disease transgenic mice and assessed the effect on the neuropathology, neuroinflammation mediators and neurotrophic factor levels and motor coordination. We found that upon transplantation into the cerebellum of adult Machado-Joseph disease mice, cerebellar neural stem cells differentiate into neurons, astrocytes and oligodendrocytes. Importantly, cerebellar neural stem cell transplantation mediated a significant and robust alleviation of the motor behaviour impairments, which correlated with preservation from Machado-Joseph disease-associated neuropathology, namely reduction of Purkinje cell loss, reduction of cellular layer shrinkage and mutant ATXN3 aggregates. Additionally, a significant reduction of neuroinflammation and an increase of neurotrophic factors levels was observed, indicating that transplantation of cerebellar neural stem cells also triggers important neuroprotective effects. Thus, cerebellar neural stem cells have the potential to be used as a cell replacement and neuroprotective approach for Machado-Joseph disease therapy.

  2. Joseph Hersey Pratt (1872-1956): An early proponent of cognitive-behavioural therapy in America.

    PubMed

    Ambrose, Charles T

    2014-02-01

    The treatment of mild psychoneuroses in America began shifting in the 1950s from Freudian psychoanalysis to various forms of psychotherapy that do not delve into patient's subconscious. Some of the new approaches were termed cognitive, behavioural or cognitive behavioural therapy and in America were practised notably by Joseph Wolpe, Albert Ellis and Aaron T Beck. Modern psychiatric literature makes little mention of two prior innovators in this area - the French neurologist Jules Dejerine and his Boston disciple Joseph H Pratt. In the early 1900s, Dejerine treated patients at La Salpêtrière in Paris using techniques adopted subsequently by Pratt during the 1930s and employed by the trio some decades later. This paper revisits the early history of psychotherapy in America and includes a brief summary of Pratt's medical career.

  3. Estimating vegetation coverage in St. Joseph Bay, Florida with an airborne multispectral scanner

    NASA Technical Reports Server (NTRS)

    Savastano, K. J.; Faller, K. H.; Iverson, R. L.

    1984-01-01

    A four-channel multispectral scanner (MSS) carried aboard an aircraft was used to collect data along several flight paths over St. Joseph Bay, FL. Various classifications of benthic features were defined from the results of ground-truth observations. The classes were statistically correlated with MSS channel signal intensity using multivariate methods. Application of the classification measures to the MSS data set allowed computer construction of a detailed map of benthic features of the bay. Various densities of segrasses, various bottom types, and algal coverage were distinguished from water of various depths. The areal vegetation coverage of St. Joseph Bay was not significantly different from the results of a survey conducted six years previously, suggesting that seagrasses are a very stable feature of the bay bottom.

  4. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

    PubMed

    Teixeira-Castro, Andreia; Jalles, Ana; Esteves, Sofia; Kang, Soosung; da Silva Santos, Liliana; Silva-Fernandes, Anabela; Neto, Mário F; Brielmann, Renée M; Bessa, Carlos; Duarte-Silva, Sara; Miranda, Adriana; Oliveira, Stéphanie; Neves-Carvalho, Andreia; Bessa, João; Summavielle, Teresa; Silverman, Richard B; Oliveira, Pedro; Morimoto, Richard I; Maciel, Patrícia

    2015-11-01

    Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease.

  5. Treating HIV is rarely an emergency. An interview with Joseph Sonnabend. Interview by Bob Huff.

    PubMed

    Sonnabend, Joseph

    2005-01-01

    Dr. Joseph Sonnabend was one of the earliest AIDS clinicians and researchers. He helped introduce the concept of safer sex and was a pioneer in establishing community-based research. He was mentor to many of the first generation of AIDS activists and is famous among patients for being the first doctor who treated them as equals. He recently retired from medical practice in New York and now lives in London.

  6. Wildlife Habitat Impact Assessment, Chief Joseph Dam Project, Washington : Project Report 1992.

    SciTech Connect

    Kuehn, Douglas; Berger, Matthew

    1992-01-01

    Under the Pacific Northwest Electric Power Planning and Conservation Act of 1980, and the subsequent Northwest Power Planning Council`s Columbia River Basin Fish and Wildlife Program, a wildlife habitat impact assessment and identification of mitigation objectives have been developed for the US Army Corps of Engineer`s Chief Joseph Dam Project in north-central Washington. This study will form the basis for future mitigation planning and implementation.

  7. Arthur Conan Doyle, Joseph Bell, and Sherlock Holmes. A neurologic connection.

    PubMed

    Westmoreland, B F; Key, J D

    1991-03-01

    Neurologists, like physicians in several other medical specialties, can lay claim to Sherlock Holmes as one of their own. This assertion is validated by the number of neurologic conditions, such as seizures, stroke, syncope, encephalopathies, and head trauma, that are mentioned in the stories and novels. In addition, the article reviews the powers of observation and the deductive approach utilized by Conan Doyle and Joseph Bell, the models for Sherlock Holmes, and how these skills can be applied to medical problems.

  8. Machado-Joseph disease in a Nigerian family: mutational origin and review of the literature.

    PubMed

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-02-01

    Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years.

  9. Joseph Warren: a discussion of his life and analysis of his death.

    PubMed

    Holland, Ryan; Sabourin, Victor M; Gandhi, Chirag D; Carmel, Peter W; Prestigiacomo, Charles J

    2015-07-01

    As his fellow soldiers ran past him, Joseph Warren stood bravely on Bunker Hill. It was June 17, 1775, and British troops were fighting the colonists in one of the early battles of the American Revolution. The British had already attempted two major assaults that day, and the third would end with Warren's death. He was a medical doctor, public figure, and general who spent his life and last living moments fighting for freedom for the American colonists. After the battle, there was much confusion about what had happened to Joseph Warren. Some thought he had survived the battle; other accounts differed on how exactly he had died. The details of the events on Bunker Hill remained a mystery until the following year, when Paul Revere helped identify Warren's body by the false teeth that had been implanted years earlier. Warren's remains showed that his head had been struck by a bullet. Analysis of the skull helped to sift through the differing tales of Warren's death and thus unveil the truth about what occurred that day. The smaller bullet wound in the left maxilla suggests that he was not shot while retreating with the rest of the soldiers. The larger exit wound in the right occiput illustrates that the bullet's trajectory crossed the midline of the brain and most likely injured the brainstem. Therefore, contrary to rumors that circulated at the time, Joseph Warren most likely was killed instantly at the Battle of Bunker Hill while heroically facing his enemy.

  10. Machado–Joseph disease in a Nigerian family: mutational origin and review of the literature

    PubMed Central

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-01-01

    Machado–Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years. PMID:24781759

  11. Joseph Warren: a discussion of his life and analysis of his death.

    PubMed

    Holland, Ryan; Sabourin, Victor M; Gandhi, Chirag D; Carmel, Peter W; Prestigiacomo, Charles J

    2015-07-01

    As his fellow soldiers ran past him, Joseph Warren stood bravely on Bunker Hill. It was June 17, 1775, and British troops were fighting the colonists in one of the early battles of the American Revolution. The British had already attempted two major assaults that day, and the third would end with Warren's death. He was a medical doctor, public figure, and general who spent his life and last living moments fighting for freedom for the American colonists. After the battle, there was much confusion about what had happened to Joseph Warren. Some thought he had survived the battle; other accounts differed on how exactly he had died. The details of the events on Bunker Hill remained a mystery until the following year, when Paul Revere helped identify Warren's body by the false teeth that had been implanted years earlier. Warren's remains showed that his head had been struck by a bullet. Analysis of the skull helped to sift through the differing tales of Warren's death and thus unveil the truth about what occurred that day. The smaller bullet wound in the left maxilla suggests that he was not shot while retreating with the rest of the soldiers. The larger exit wound in the right occiput illustrates that the bullet's trajectory crossed the midline of the brain and most likely injured the brainstem. Therefore, contrary to rumors that circulated at the time, Joseph Warren most likely was killed instantly at the Battle of Bunker Hill while heroically facing his enemy. PMID:26126399

  12. A 325-year reconstruction of St. Joseph River streamflow using tree rings

    NASA Astrophysics Data System (ADS)

    Schmidt, Karly R.

    The use of tree ring widths as indicators of water resource availability affords annual-scale resolution in the reconstruction of streamflow prior to the limited instrumental record. While an abundance of streamflow reconstructions have been conducted in the western United States, few have been undertaken in the eastern half of the country. This study aims to enhance understanding of regional hydroclimate in the Great Lakes region by presenting a 325-year streamflow reconstruction for the St. Joseph River, as well as contributing two new tree ring-width chronologies in Indiana and Michigan. A variety of factors potentially influencing the chance of successful streamflow reconstruction are also posited and discussed. A total of 55 tree ring width chronologies from Indiana, Illinois, Michigan, Wisconsin, and Ontario were examined using standard methods in dendrochronology and nested principal component analysis (PCA) to reconstruct St. Joseph River streamflow to 1675 with greater skill than climatology. The resulting overall reconstruction and periods identified as severe droughts and pluvials were in general agreement with other dendroclimatological studies in the eastern U.S. The findings suggest that the instrumental record (beginning in 1924) does not accurately depict long-term streamflow variability of the St. Joseph River. The reconstructed values tend to overestimate the intensity and duration of pluvial periods, but also show that droughts in the region were of similar intensity to those in the more recent past, but were of longer duration. This suggests that water resource managers may need to consider a wider range of variability than previously indicated by the instrumental record.

  13. Uniting Mandelbrot’s Noah and Joseph Effects in Toy Models of Natural Hazard Time Series

    NASA Astrophysics Data System (ADS)

    Credgington, D.; Watkins, N. W.; Chapman, S. C.; Rosenberg, S. J.; Sanchez, R.

    2009-12-01

    The forecasting of extreme events is a highly topical, cross-disciplinary problem. One aspect which is potentially tractable even when the events themselves are stochastic is the probability of a “burst” of a given size and duration, defined as the area between a time series and a constant threshold. Many natural time series depart from the simplest, Brownian, case and in the 1960s Mandelbrot developed the use of fractals to describe these departures. In particular he proposed two kinds of fractal model to capture the way in which natural data is often persistent in time (his “Joseph effect”, common in hydrology and exemplified by fractional Brownian motion) and/or prone to heavy tailed jumps (the “Noah effect”, typical of economic index time series, for which he gave Levy flights as an examplar). Much of the earlier modelling, however, has emphasised one of the Noah and Joseph parameters (the tail exponent mu and one derived from the temporal behaviour such as power spectral beta) at the other one's expense. I will describe work [1] in which we applied a simple self-affine stable model-linear fractional stable motion (LFSM)-which unifies both effects to better describe natural data, in this case from space physics. I will show how we have resolved some contradictions seen in earlier work, where purely Joseph or Noah descriptions had been sought. I will also show recent work [2] using numerical simulations of LFSM and simple analytic scaling arguments to study the problem of the area between a fractional Levy model time series and a threshold. [1] Watkins et al, Space Science Reviews [2005] [2] Watkins et al, Physical Review E [2009

  14. The Forgotten Forefather: Joseph James Kinyoun and the Founding of the National Institutes of Health

    PubMed Central

    Morens, David M.; Fauci, Anthony S.

    2012-01-01

    ABSTRACT In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview examines Joseph James Kinyoun (1860 to 1919), the 1887 founder of a federal Hygienic Laboratory that is considered the direct ancestor of the modern NIH, and explores the development of NIH as it was shaped by, and in turn shaped, the new field of microbiology. PMID:22736540

  15. Li-Fraumeni syndrome: Discovery and future challenges - Joseph Fraumeni Symposium

    Cancer.gov

    In May 2014, NCI’s Division of Cancer Epidemiology and Genetics (DCEG) hosted Cancer Epidemiology: From Pedigrees to Populations, a scientific symposium honoring 50 years of visionary leadership by Dr. Joseph F. Fraumeni, Jr., the founding Director of DCEG. In this video, Dr. Stephen Chanock of NCI provides opening remarks. Dr. David Schottenfeld of the University of Michigan moderates a session on the search for cancer susceptibility genes. Dr. Louise Strong of University of Texas MD Anderson Cancer Center speaks about the discovery and future challenges of Li-Fraumeni syndrome research. For more information on this symposium, visit http://dceg.cancer.gov/news-events/Fraumeni-symposium-speakers.

  16. Decoupling the Stationary Navier-Stokes-Darcy System with the Beavers-Joseph-Saffman Interface Condition

    DOE PAGES

    Cao, Yong; Chu, Yuchuan; He, Xiaoming; Wei, Mingzhen

    2013-01-01

    This paper proposes a domain decomposition method for the coupled stationary Navier-Stokes and Darcy equations with the Beavers-Joseph-Saffman interface condition in order to improve the efficiency of the finite element method. The physical interface conditions are directly utilized to construct the boundary conditions on the interface and then decouple the Navier-Stokes and Darcy equations. Newton iteration will be used to deal with the nonlinear systems. Numerical results are presented to illustrate the features of the proposed method.

  17. [Skull and mandible. On Joseph Beuys' "ancient sled." Medical art history observation].

    PubMed

    Schulz, H

    1999-05-01

    Few people are aware that Joseph Beuys (1921-1986), one of the most important artists at the end of the twentieth century, studied various aspects of the human skull. Beuys used teeth (especially molars), antlers, and horns as organically differentiated formations of solid substances of the viscerocranium, associating them in a very visual way with the "streaming circulation" principle. In addition, in his early drawings, in particular, Beuys replaced the lower jaw with a sledge. The artist has thus created interesting and strange constructions concerned with the structure of the jaw and the craniovertebral transition. Certain characteristic structural elements of sledges show a remarkable formal analogy to the ramus of mandible. The base of the body of mandible becomes a sliding surface, the iron runners of the sledge. Replacing the lower jaw with a sledge raises questions concerning movement and the effect of energy on the skull and on the earth. The artist's understanding of anatomy goes for beyond than that of normal medicine. It is formed by his thinking, his energy plan, and by his own theory of metamorphosis. With his skull and Urschlitten motif, Beuys makes us aware of the transitory layers of consciousness between life and death. "Head" and "sledge" are early forms of sculptural thinking in the work of Joseph Beuys.

  18. Agricultural land use and water quality in the upper St. Joseph River basin, Michigan

    USGS Publications Warehouse

    Cummings, T. Ray

    1978-01-01

    Land use in the upper St. Joseph River basin of south-central Michigan is primarily agricultural. In the 144-square-mile area, the chemical and physical characteristics of water are determined by the climate and soils, as well as by land conservation practices. Municipal waste discharges affect water quality at some locations, as do the larger lakes and ponds. Data indicate that mean discharge from the basin is 135 cubic feet per second. About half this flow is contributed to the St. Joseph River by three major tributaries: Beebe Creek (36 cubic feet per second); Sand Creek (24 cubic feet per second); and Soap Creek (13 cubic feet per second). Runoff from 21 drainage areas delineated for the investigation ranged from 0.22 to 4.07 cubic feet per second per square mile; both the higher and lower values are largely the result of naturally occurring inter- and intrabasin transfers of water.Suspended-sediment concentrations are low throughout the basin, rarely exceeding 100 milligrams per liter. Mean concentrations at four daily sampling stations on the major tributaries and on the St. Joseph River ranged from 9.7 milligrams per liter to 38 milligrams per liter. The maximum sediment yield was 182 pounds per acre per year. Deposition of sediment in five of the 21 areas resulted in a net loss of sediment transported, and thus “negative” yields.Nitrogen and phosphorus concentrations do not vary greatly from site to site. Mean concentrations of total nitrogen at downstream sites on Beebe, Sand, and Soap Creeks, and on the St. Joseph River ranged from 1.5 to 1.8 milligrams per liter. About 90 percent of all nitrogen, and 66 percent of all phosphorus, is transported in solution. Land used principally for agriculture has a mean total nitrogen yield of 4.9 pounds per acre per year and a mean total phosphorus yield of 0.13 pounds per year. A comparison of total nitrogen and total phosphorus yields with type of agricultural use showed few relationships; nitrogen yield

  19. Research Administration in History: The Development of OMB Circular A-110 through Joseph Warner's COGR Subcommittee, 1976-1979

    ERIC Educational Resources Information Center

    Myers, Phillip E.; Smith, Marie F.

    2008-01-01

    Research administrators can be assisted in resolving issues with awareness of the critical period of policy formation divulged in the Joseph Warner Papers. He and his colleagues on the Subcommittee on Grants and Contracts Provisions of COGR adopted the philosophy that research administrators needed flexibility and reduced paperwork and costs.…

  20. 77 FR 61657 - Indiana Northeastern Railroad Company-Abandonment Exemption-In Branch and St. Joseph Counties, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... St. Joseph Counties, MI Indiana Northeastern Railroad Company (IN) has filed a verified notice of... between milepost 81.32 near Coldwater in Branch County, Mich., and milepost 100.69 near Sturgis in St.... Rail Lines, 5 I.C.C. 2d 377 (1989). Any request for a stay should be filed as soon as possible so...

  1. Defining American Heroes: Analyzing the Metamorphosis of the War Hero in Twentieth Century War Films Using Joseph Campbell's, "Hero's Journey."

    ERIC Educational Resources Information Center

    Frith, Luci A.

    In "The Hero's Journey" Joseph Campbell identifies the patterns that inform the myths of the "hero" throughout recorded history. By using Campbell's template, this paper examines how the American war hero is portrayed and has been portrayed in film. The paper states that Americans not only define their war heroes in films but also use these film…

  2. Effects of Agricultural and Conservation Practices on Nutrients Losses from the St. Joseph River Watershed, Northeast Indiana

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Agriculture has been identified as a primary contributor to nutrients that cause algal blooms in the Gulf of Mexico and Lake Erie. Since 2002, we have been monitoring water quality from agricultural drainage ditches in the St. Joseph River watershed to assess the impacts of agricultural and conserva...

  3. A Study of Academic Exercises Used for Teaching Social Studies in English at Saint Joseph Bangna School Thailand

    ERIC Educational Resources Information Center

    McBain, Robert

    2011-01-01

    The purpose of this research was to highlight the problems ESL students faced when studying social studies at Saint Joseph Bangna School. In particular, what improvements could be made to the kinds of academic exercises contained within the books & websites as teaching materials. It was designed around three research questions relating to what…

  4. Use of surface and borehole geophysics to delineate the glacial-drift stratigraphy of northeastern St. Joseph County, Indiana

    USGS Publications Warehouse

    Bayless, E. Randall; Westjohn, David B.; Watson, Lee R.

    1995-01-01

    Inverse models of direct current electrical- resistivity sounding data and normal-resistivity and natural-gamma logs were used to assist delineation of the glacial-drift stratigraphy in a 580-square- kilometer area of northeastern St. Joseph County, Indiana. Unconsolidated deposits in the study area are composed of glacial-drift, including outwash, till, and lacustrine sediments; thicknesses range from about 15 to more than 70 meters. The glacial outwash deposits are mostly composed of sand and gravel and are the primary source of drinking water to northeastern St. Joseph County. The glacial till and glacio-lacustrine deposits contain a larger fraction of clay than the outwash deposits and may retard ground-water flow between shallow and deeper sand and gravel aquifers. Results of the geophysical measurements collected during this study indicate that glacial-drift deposits in the area north and east of the St. Joseph River are mostly composed of sand and gravel with inter-layered clay-rich deposits that are laterally discontinuous. In the area south of the St. Joseph River, the thickness of sand and gravel deposits diminishes, and clay-rich deposits dominate the stratigraphy. The presence of an electrically conductive bedrock, the Ellsworth Shale, beneath the glacial-drift deposits is identified in inverse models of direct current electrical-resistivity sounding data.

  5. Joseph V. Denney, the Land-Grant Mission, and Rhetorical Education at Ohio State: An Institutional History

    ERIC Educational Resources Information Center

    Mendenhall, Annie S.

    2011-01-01

    This essay provides an account of The Ohio State University's (OSU) rhetoric department during the tenure of Joseph Villiers Denney, arguing that he appropriated and repurposed national trends in education and rhetoric in ways that complicate the narrative of rhetoric and composition's decline in the late nineteenth century. In this essay, the…

  6. RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease

    PubMed Central

    Onofre, Isabel; Albuquerque, David; Déglon, Nicole; Pereira de Almeida, Luís

    2014-01-01

    Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene silencing at an early time-point is able to prevent the appearance of motor behavior deficits typical of the disease when initiated before onset of the disease had not been explored. Here, using a lentiviral-mediated allele-specific silencing of mutant ataxin-3 in an early pre-symptomatic cerebellar mouse model of Machado-Joseph disease we show that this strategy hampers the development of the motor and neuropathological phenotypic characteristics of the disease. At the histological level, the RNA-specific silencing of mutant ataxin-3 decreased formation of mutant ataxin-3 aggregates, preserved Purkinje cell morphology and expression of neuronal markers while reducing cell death. Importantly, gene silencing prevented the development of impairments in balance, motor coordination, gait and hyperactivity observed in control mice. These data support the therapeutic potential of RNA interference for Machado-Joseph disease and constitute a proof of principle of the beneficial effects of early allele-specific silencing for therapy of this disease. PMID:25144231

  7. [The three lifes of Doctor Joseph-Ignace Guillotin (1738-1814)].

    PubMed

    Noterman, J

    2011-01-01

    The life of Joseph-Ignace Guillotin can be divided into three periods. The first part of his life consists of his training and his settling as a medical consultant and influential freemason from 1738 to 1788. The second part primarily consists of his political role for a short period during the Revolution (from 1788 to 1791). It was during that time that he proposed a change in the functioning of the General States, a penal Code reform, and the reorganization of the teaching and medical exercice. Finally, during the third period of his life, he focused on promoting vaccination against smallpox and founded with others the present-day Academy of Medicine of Paris.

  8. [Dr. Joseph Chazanowicz (1844-1919) and the National Library in Jerusalem].

    PubMed

    Ohry, Avi

    2014-01-01

    Dr. Joseph Chazanowicz (1844-1919), was a Russian physician, and founder of the Jewish National Library in JerusaLem. After completing his studies at the Jewish school and at the gymnasium of Grodno, Chazanowicz went to Königsberg, Germany to study medicine and finished his studies in 1872. Returning to Russia, he began to practice at Byelostok's Jewish hospital. Chazanowicz founded the Hovevei Ziyyon ["Lovers of Zion"] society and also the Linat Ha-Zedek ("Hospice for the Poor")--caring for the poor. In 1890 he visited Palestine and conceived the idea of founding a library in Jerusalem, together with the B'nai B'rith organization. In 1896 he sent his large collection of books, amounting to nearly 10,000 volumes, to Jerusalem as the beginning of the Abarbanel library. The enlargement of this library and the collection of funds to erect a special building for it became the life-work of Chazanowicz.

  9. Joseph Lovell, MD (1788-1836): First US army surgeon general.

    PubMed

    Craig, Stephen C

    2016-08-01

    Joseph Lovell, trained in medicine at Harvard and in military medicine/surgery by the War of 1812, became the first Surgeon General to sit on the reorganised army staff at the tender age of 29 in 1818. With a keen intellect, medical acumen, and wartime experiences for his tools and a close supporting relationship with Commanding General Jacob Jennings Brown and Secretary of War John C Calhoun (1728-1850), Lovell constructed an efficient and effective organisational and administrative framework for the new Medical Department of the US Army. Moreover, he not only redefined the role of the American military physician but also established the professional dignity, respectability and value of the medical officer among line officers and staff. Lovell's 18-year tenure came to an abrupt end, but the operational framework he created became both foundation and legacy for his successors.

  10. The Wichita Valley irrigation project: Joseph Kemp, boosterism, and conservation in northwest Texas, 1886-1939.

    PubMed

    Anderson, Jahue

    2011-01-01

    This is the story of failure: in this case, an irrigation project that never met its boosters' expectations. Between 1880 and 1930, Wichita Falls entrepreneur Joseph Kemp dreamed of an agrarian Eden on the Texas rolling plains. Kemp promoted reclamation and conservation and envisioned the Big Wichita River Valley as the "Irrigated Valley." But the process of bringing dams and irrigation ditches to the Big Wichita River ignored knowledge of the river and local environment, which ultimately was key to making these complex systems work. The boosters faced serious ecological limitations and political obstacles in their efforts to conquer water, accomplishing only parts of the grandiose vision. Ultimately, salty waters and poor drainage doomed the project. While the livestock industry survived and the oil business thrived in the subsequent decades, the dream of idyllic irrigated farmsteads slowly disappeared.

  11. Sir Edward Appleton and Joseph Priestley: two giants of electrical science

    NASA Astrophysics Data System (ADS)

    Excell, P. S.

    The life of Sir Edward Appleton is reviewed, in commemoration of the recent centenary of his birth. Appleton discovered the ionosphere and devoted much of his life to investigations of its properties, receiving the Nobel Prize for physics as a result. He became a senior government scientist in World War II and afterwards was appointed Vice-Chancellor of Edinburgh University. The influence of his roots in the city of Bradford is emphasized and compared with the case of Joseph Priestley, also born near Bradford some 160 yr earlier. Priestley was a major early investigator of electrical phenomena and compiled a comprehensive treatise on the electrical knowledge of his day. He was the first person to present an experimental proof of the inverse-square law of electrostatic force, although he is usually better remembered as the discoverer of oxygen.

  12. Machado-Joseph disease is genetically different from Holguin dominant ataxia (SCA2)

    SciTech Connect

    Silveria, I.; Manaia, A. Hopital Necker-Enfants Malades, Paris ); Melki, J.; Burlet, P.; Rozet, J.M.; Munnich, A. ); Magarino, C.; Gispert, S. Centro Nacional Genetica Medica, Havana ); Lunkes, A.; Auburger, G. )

    1993-09-01

    Machado-Joseph disease (MJD) and Holguin ataxia (SCA2) are autosomal dominant multisystem degenerations with spinocerebellar involvement that are predominant among people of Portuguese-Azorean and of Cuban descent, respectively. Their clinical distinction may at times be difficult to make in individual patients, due to significant phenotypic overlapping (similar overall age-of-onset and duration of cerebellar ataxia, eye movement, and, often, other common problems). The recent mapping of SCA2 to chromosome 12q provided another candidate region for linkage studies of MJD. Original data on 10 families with Holguin ataxia show that the locus of phenylalanine hydroxylase (PAH) on chromosome 12q is linked to SCA2 at 4 cM and is thus far its closest marker. The exclusion of linkage 15 cM on each side of PAH in 16 families with MJD shows that these two forms of dominant ataxia are genetically distinct and at different chromosomal locations (nonallelic). 20 refs., 2 tabs.

  13. The Wichita Valley irrigation project: Joseph Kemp, boosterism, and conservation in northwest Texas, 1886-1939.

    PubMed

    Anderson, Jahue

    2011-01-01

    This is the story of failure: in this case, an irrigation project that never met its boosters' expectations. Between 1880 and 1930, Wichita Falls entrepreneur Joseph Kemp dreamed of an agrarian Eden on the Texas rolling plains. Kemp promoted reclamation and conservation and envisioned the Big Wichita River Valley as the "Irrigated Valley." But the process of bringing dams and irrigation ditches to the Big Wichita River ignored knowledge of the river and local environment, which ultimately was key to making these complex systems work. The boosters faced serious ecological limitations and political obstacles in their efforts to conquer water, accomplishing only parts of the grandiose vision. Ultimately, salty waters and poor drainage doomed the project. While the livestock industry survived and the oil business thrived in the subsequent decades, the dream of idyllic irrigated farmsteads slowly disappeared. PMID:22180941

  14. Sympathetic science: Charles Darwin, Joseph Hooker, and the passions of Victorian naturalists.

    PubMed

    Endersby, Jim

    2009-01-01

    This essay examines the complex tangle of emotional and scientific attachments that linked Darwin and botanist Joseph Dalton Hooker. Analyzing their roles as husbands, fathers, and novel readers demonstrates that possessing and expressing sympathy was as important for Victorian naturalists as it was for Victorian husbands. Sympathy was a scientific skill that Victorian naturalists regarded as necessary to fully understand the living world; although sympathy became increasingly gendered as feminine over the course of the century, its importance to male naturalists requires us to rethink the ways gender roles were negotiated in Victorian Britain. Botany was, for men like Darwin and Hooker, an acceptably masculine pursuit that nevertheless allowed--and even required--them to be sensitive and sympathetic. PMID:19824199

  15. A life more ordinary: the dull life but interesting times of joseph dalton hooker.

    PubMed

    Endersby, Jim

    2011-01-01

    The life of Joseph Dalton Hooker (1817-1911) provides an invaluable lens through which to view mid-Victorian science. A biographical approach makes it clear that some well-established narratives about this period need revising. For example, Hooker's career cannot be considered an example of the professionalisation of the sciences, given the doubtful respectability of being paid to do science and his reliance on unpaid collectors with pretensions to equal scientific and/or social status. Nor was Hooker's response to Darwin's theories either straightforward or contradictory; it only makes sense as carefully crafted equivocation when seen in the context of his life and career. However, the importance of Hooker's life is ultimately its typicality; what was true of Hooker was true of many other Victorian men of science. PMID:21336663

  16. The fate of the bird specimens from Cook's voyages possessed by Sir Joseph Banks.

    PubMed

    Medway, David G

    2009-10-01

    Joseph Banks possessed the greater part of the zoological specimens collected on James Cook's three voyages round the world (1768-1780). In early 1792, Banks divided his zoological collection between John Hunter and the British Museum. It is probable that those donations together comprised most of the zoological specimens then in the possession of Banks, including such bird specimens as remained of those that had been collected by himself and Daniel Solander on Cook's first voyage, and those that had been presented to him from Cook's second and third voyages. The bird specimens included in the Banks donations of 1792 became part of a series of transactions during the succeeding 53 years which involved the British Museum, the Royal College of Surgeons of England, and William Bullock. It is a great pity that, of the extensive collection of bird specimens from Cook's voyages once possessed by Banks, only two are known with any certainty to survive.

  17. Sympathetic science: Charles Darwin, Joseph Hooker, and the passions of Victorian naturalists.

    PubMed

    Endersby, Jim

    2009-01-01

    This essay examines the complex tangle of emotional and scientific attachments that linked Darwin and botanist Joseph Dalton Hooker. Analyzing their roles as husbands, fathers, and novel readers demonstrates that possessing and expressing sympathy was as important for Victorian naturalists as it was for Victorian husbands. Sympathy was a scientific skill that Victorian naturalists regarded as necessary to fully understand the living world; although sympathy became increasingly gendered as feminine over the course of the century, its importance to male naturalists requires us to rethink the ways gender roles were negotiated in Victorian Britain. Botany was, for men like Darwin and Hooker, an acceptably masculine pursuit that nevertheless allowed--and even required--them to be sensitive and sympathetic.

  18. Cost analysis of magnetic resonance imaging at St. Joseph's Health Centre of London.

    PubMed Central

    Reese, L

    1987-01-01

    In April 1986 St. Joseph's Health Centre of London, Ont., completed 3 years of operating a magnetic resonance imaging unit. The first 2 years were devoted to research and development. From Apr. 1, 1985, to Mar. 31, 1986, the unit operated as the first clinical service unit in Canada. Over the 12 months 1671 patients (an average of 9 patients per 12-hour day) were examined. Studies of the brain (62%) and the spine (21%) accounted for most of the procedures. The operating costs for the year were $892,000; revenues totalled $449,000, for a deficit of $443,000. The average technical cost per patient was $534. Increasing the number of patients examined per year would lower the cost to $431. PMID:3815214

  19. [The life of Joseph Haydn from a medical point of view (author's transl)].

    PubMed

    Franken, F H

    1976-06-25

    Joseph Haydn (1732 to 1809) had hardly been troubled by any illness of note, apart from a chronic nasal polyp until 1799. During the composition of the oratoria "The Seasons" (1799 to 1801), the signs of cerebral arteriosclerosis with cardiac insufficiency made their appearance. Haydn's creative strength subsequently declined rapidly and he was virtually unable to compose any more after he had finished "The Seasons" until his death in 1809. The plan to compose a third oratoria "The Last Judgement" ended abortively. Haydn himself suffered acutely from the inactivity imposed on him by the illness, as documented by various sources. Hadyn remained fully conscious right up to the time of his death, which presumably resulted from cardiac failure. Haydn's grave was ransacked only a few days after the funeral and his skull was snatched. It has been finally restored to his resting place in Eisenstadt only as recently as 1954 after a protracted and devious journey.

  20. A Science Superior to Music: Joseph Sauveur and the Estrangement between Music and Acoustics

    NASA Astrophysics Data System (ADS)

    Fix, Adam

    2015-09-01

    The scientific revolution saw a shift from the natural philosophy of music to the science of acoustics. Joseph Sauveur (1653-1716), an early pioneer in acoustics, determined that science as understood in the eighteenth century could not address the fundamental problems of music, particularly the problem of consonance. Building on Descartes, Mersenne, and Huygens especially, Sauveur drew a sharp divide between sound and music, recognizing the former as a physical phenomenon obeying mechanical and mathematical principles and the latter as an inescapably subjective and unquantifiable perception. While acoustics grew prominent in the Académie des sciences, music largely fell out of the scientific discourse, becoming primarily practiced art rather than natural philosophy. This study illuminates what was considered proper science at the dawn of the Enlightenment and why one particular branch of natural philosophy—music—did not make the cut.

  1. The Interaction of Physics, Mechanics and Mathematics in Joseph Liouville's Research

    NASA Astrophysics Data System (ADS)

    Lützen, Jesper

    As many of his contemporaries did, Joseph Liouville often emphasized the importance of physics for mathematical research. His own works provide a host of examples of interactions between mathematics and physics. This paper analyses some of them. It is shown how Laplacian physics gave rise to Liouville's theory of differentiation of arbitrary order, how Kelvin's research on electrostatics gave rise to Liouville's theorem about conformal mappings and how the theory of heat conduction gave rise to Sturm-Liouville theory. It will be shown how the problem of the shape of the planets was an important inspiration for Liouville's far reaching studies of Lamé functions and spectral theory of a particular type of integral operators. Finally the interactions between Liouville's work on mechanics and differential geometry will be discussed.

  2. A life more ordinary: the dull life but interesting times of joseph dalton hooker.

    PubMed

    Endersby, Jim

    2011-01-01

    The life of Joseph Dalton Hooker (1817-1911) provides an invaluable lens through which to view mid-Victorian science. A biographical approach makes it clear that some well-established narratives about this period need revising. For example, Hooker's career cannot be considered an example of the professionalisation of the sciences, given the doubtful respectability of being paid to do science and his reliance on unpaid collectors with pretensions to equal scientific and/or social status. Nor was Hooker's response to Darwin's theories either straightforward or contradictory; it only makes sense as carefully crafted equivocation when seen in the context of his life and career. However, the importance of Hooker's life is ultimately its typicality; what was true of Hooker was true of many other Victorian men of science.

  3. Sir Joseph Barcroft: one victorian physiologist's contributions to a half century of discovery.

    PubMed

    Longo, Lawrence D

    2016-03-01

    During the first half of the 20th Century, Joseph Barcroft, KBE, FRS of Cambridge University became a world leader in respiratory physiology. He determined the role of neural stimulation in the oxygen consumption of several organs, established many of the factors that regulate the binding of oxygen to haemoglobin, explored the determinants of a human's acclimatization to high altitude and developed the field of fetal cardiovascular physiology. Chair of the Cambridge Department of Physiology from 1925 to 1937, he served as a consultant and member of many UK governmental committees. During World War I, he led a British research unit exploring the effects of poisonous gases on pulmonary function and related problems. In addition to his almost 300 publications, several of his monographs are considered as classics. PMID:25929679

  4. Review of the hydrologic data-collection network in the St Joseph River basin, Indiana

    USGS Publications Warehouse

    Crompton, E.J.; Peters, J.G.; Miller, R.L.; Stewart, J.A.; Banaszak, K.J.; Shedlock, R.J.

    1986-01-01

    The St. Joseph River Basin data-collection network in the St. Joseph River for streamflow, lake, ground water, and climatic stations was reviewed. The network review included only the 1700 sq mi part of the basin in Indiana. The streamflow network includes 11 continuous-record gaging stations and one partial-record station. Based on areal distribution, lake effect , contributing drainage area, and flow-record ratio, six of these stations can be used to describe regional hydrology. Gaging stations on lakes are used to collect long-term lake-level data on which to base legal lake levels, and to monitor lake-level fluctuations after legal levels are established. More hydrogeologic data are needed for determining the degree to which grouhd water affects lake levels. The current groundwater network comprises 15 observation wells and has four purposes: (1) to determine the interaction between groundwater and lakes; (2) to measure changes in groundwater levels near irrigation wells; (3) to measure water levels in wells at special purpose sites; and (4) to measure long-term changes in water levels in areas not affected by pumping. Seven wells near three lakes have provided sufficient information for correlating water levels in wells and lakes but are not adequate to quantify the effect of groundwater on lake levels. Water levels in five observation wells located in the vicinity of intensive irrigation are not noticeably affected by seasonal withdrawals. The National Weather Sevice operates eight climatic stations in the basin primarily to characterize regional climatic conditions and to aid in flood forecasting. The network meets network-density guidelines established by the World Meterological Organization for collection of precipitation and evaporation data but not guidelines suggested by the National Weather Service for density of precipitation gages in areas of significant convective rainfalls. (Author 's abstract)

  5. A short biography of Joseph Fourier and historical development of Fourier series and Fourier transforms

    NASA Astrophysics Data System (ADS)

    Debnath, Lokenath

    2012-07-01

    The profound study of nature is the most fertile source of mathematical discoveries. Not only does this study, by offering a definite goal to research, have the advantage of excluding vague questions and futile calculations, but it is also a sure means of moulding analysis itself, and discerning those elements in it which it is still essential to know and which science ought to conserve. These fundamental elements are those which recur in all natural phenomena. Joseph Fourier pure mathematics enables us to discover the concepts and laws connecting them, which gives us the key to the understanding of the phenomena of nature. Albert Einstein This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made to his splendid research contributions to mathematical physics, pure and applied mathematics and his unprecedented public service accomplishments in the history of France. This is followed by historical comments about the significant and major impact of Fourier analysis on mathematical physics, probability and mathematical statistics, mathematical economics and many areas of pure and applied mathematics including geometry, harmonic analysis, signal analysis, wave propagation and wavelet analysis. Special attention is also given to the Fourier integral formula, Brownian motion and stochastic processes and many examples of applications including isoparametric inequality, everywhere continuous but nowhere differentiable functions, Heisenberg uncertainty principle, Dirichlets' theorem on primes in

  6. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2000 Annual Report.

    SciTech Connect

    Crossley, Brian; Lockwood, Jr., Neil W.; McLellan, Jason G.

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  7. Joseph Black, carbon dioxide, latent heat, and the beginnings of the discovery of the respiratory gases.

    PubMed

    West, John B

    2014-06-15

    The discovery of carbon dioxide by Joseph Black (1728-1799) marked a new era of research on the respiratory gases. His initial interest was in alkalis such as limewater that were thought to be useful in the treatment of renal stone. When he studied magnesium carbonate, he found that when this was heated or exposed to acid, a gas was evolved that he called "fixed air" because it had been combined with a solid material. He showed that the new gas extinguished a flame, that it could not support life, and that it was present in gas exhaled from the lung. Within a few years of his discovery, hydrogen, nitrogen, and oxygen were also isolated. Thus arguably Black's work started the avalanche of research on the respiratory gases carried out by Priestley, Scheele, Lavoisier, and Cavendish. Black then turned his attention to heat and he was the first person to describe latent heat, that is the heat added or lost when a liquid changes its state, for example when water changes to ice or steam. Latent heat is a key concept in thermal physiology because of the heat lost when sweat evaporates. Black was a friend of the young James Watt (1736-1819) who was responsible for the development of early steam engines. Watt was puzzled why so much cooling was necessary to condense steam into water, and Black realized that the answer was the latent heat. The resulting improvements in steam engines ushered in the Industrial Revolution.

  8. Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease

    PubMed Central

    Esteves, Sofia; Duarte-Silva, Sara; Naia, Luana; Neves-Carvalho, Andreia; Teixeira-Castro, Andreia; Rego, Ana Cristina; Silva-Fernandes, Anabela; Maciel, Patrícia

    2015-01-01

    Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a compound with known neuroprotection activity, and previously shown to be effective in cell, fly and nematode models of MJD. We show that chronic VPA treatment in the CMVMJD135 mouse model had limited effects in the motor deficits of these mice, seen mostly at late stages in the motor swimming, beam walk, rotarod and spontaneous locomotor activity tests, and did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions. However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects, confirming target engagement. In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeutics. PMID:26505994

  9. Pierre-Joseph Macquer an eighteenth-century artisanal-scientific expert.

    PubMed

    Lehman, Christine

    2012-07-01

    Pierre-Joseph Macquer (1718-1784) is well known as one of the major chemists in the eighteenth century as a theoretician and a teacher. He is also known for his works on dyeing. This paper presents a new face of Macquer. He proposed a theory on mordants in dyeing as early as 1775. Besides his activity at the Académie des sciences, he played an important role in Government as the commissioner of dyeing from 1766 where he established close links with artisan inventors. Académicien chimiste at the royal Manufactory of Sèvres from 1757, he was also the inventor of French porcelain. His notebooks show his organization, method, courage, passion and obstinacy in the search for the paste for hard porcelain. He also proposed an interpretation of its formation. Macquer was both a theoretician and a practical expert in dyeing as well as in porcelain making. He managed to bridge the gap between science and art.

  10. Joseph John Thomson's models of matter and radiation in the early 1890s.

    PubMed

    Bordoni, Stefano

    In the late nineteenth century, Joseph John Thomson moved away from Maxwell's specific theoretical models of matter and energy, even though he continued to rely on the general framework of Maxwell's electromagnetic theory. In his 1893 book, he accomplished the conceptual drift towards a discrete model for matter, electricity, and fields. In Thomson's model, energy was linked to tubes of force, in particular to the aether contained in them and surrounding them: the energy was the kinetic energy of aether, of both a rotational and translational kind. Starting from Maxwell's electromagnetic fields, namely stresses propagating through a continuous solid medium, Thomson arrived at a representation of fields as a sea of discrete units carrying energy and momentum. He tried to transform Maxwell's theory into a unified picture in which atomic models of matter stood beside atomic models of fields. In 1904 his interpretation of X-rays was based on the integration between two complementary features of electromagnetic radiation, the continuity and the discreteness, and on some kind of fibrous aether. In recent secondary literature, the problematic conceptual link between J. J. Thomson's theory and contemporary theories on electromagnetic radiation has been underestimated. On the contrary, in the first half of the twentieth century, some physicists inquired into that link, and a widespread debate emerged, misunderstandings included.

  11. Joseph Black, carbon dioxide, latent heat, and the beginnings of the discovery of the respiratory gases.

    PubMed

    West, John B

    2014-06-15

    The discovery of carbon dioxide by Joseph Black (1728-1799) marked a new era of research on the respiratory gases. His initial interest was in alkalis such as limewater that were thought to be useful in the treatment of renal stone. When he studied magnesium carbonate, he found that when this was heated or exposed to acid, a gas was evolved that he called "fixed air" because it had been combined with a solid material. He showed that the new gas extinguished a flame, that it could not support life, and that it was present in gas exhaled from the lung. Within a few years of his discovery, hydrogen, nitrogen, and oxygen were also isolated. Thus arguably Black's work started the avalanche of research on the respiratory gases carried out by Priestley, Scheele, Lavoisier, and Cavendish. Black then turned his attention to heat and he was the first person to describe latent heat, that is the heat added or lost when a liquid changes its state, for example when water changes to ice or steam. Latent heat is a key concept in thermal physiology because of the heat lost when sweat evaporates. Black was a friend of the young James Watt (1736-1819) who was responsible for the development of early steam engines. Watt was puzzled why so much cooling was necessary to condense steam into water, and Black realized that the answer was the latent heat. The resulting improvements in steam engines ushered in the Industrial Revolution. PMID:24682452

  12. Joseph Erlanger (1874-1965): the cardiovascular investigator who won a Nobel Prize in neurophysiology.

    PubMed

    Breathnach, Caoimhghín S; Moynihan, John B

    2014-11-01

    Born in San Francisco in 1874 into the family of German immigrants in which he was the only one to proceed beyond elementary education, Joseph Erlanger graduated from the University of California (Berkeley) in 1894. He was about to enter the local Cooper Medical School when he was told that the new medical school in Johns Hopkins University (Baltimore) aimed to surpass all others, and there he graduated and was later coached for a career in academic life by William H Howell (1860-1945). In due course he held the Chairs of Physiology in the University of Wisconsin (Madison) and Washington University at St Louis, Missouri. He showed that the Bundle of His is indeed the functional link between the atria and the ventricles in the mammalian heart and that the Korotkoff sounds are produced by a 'breaker' phenomenon resulting from instability of the pulse wave in a partially occluded artery. With Herbert S Gasser (1888-1963) he was awarded the Nobel Prize in 1944 for their work on action currents in peripheral nerve fibres. The history of science occupied him during his retirement. He died at St Louis in 1965. PMID:24585622

  13. Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14

    SciTech Connect

    George-Hyslop, P. St.; McLachlan, D.R.C.; Lang, A.E.; Wherrett, J.R.; Rogaeva, E.; Tsuda, T.; Rogaev, E.I.; Liang, Y.; Huterer, J.; Kennedy, J. )

    1994-07-01

    A locus for Machado-Joseph disease (MJD) has recently been mapped to a 30-cM region of chromosome 14q in five pedigrees of Japanese descent. MJD is a clinically pleomorphic neurodegenerative disease that was originally described in subjects of Azorean descent. In light of the nonallelic heterogeneity in other inherited spinocerebellar ataxias, the authors were interested to determine if the MJD phenotype in Japanese and Azorean pedigrees arose from mutations at the same locus. They provide evidence that MJD in five pedigrees of Azorean descent is also linked to chromosome 14q in an 18-cM region between the markers D14S67 and AACT (multipoint lod score +7.00 near D14S81). They also report molecular evidence for homozygosity at the MJD locus in an MJD-affected subject with severe, early-onset symptoms. These observations confirm the initial report of linkage of MJD to chromosome 14; suggest that MJD in Japanese and Azorean subjects may represent allelic or identical mutations at the same locus; and provide one possible explanation (MJD gene dosage) for the observed phenotypic heterogeneity in this disease. 22 refs., 3 figs., 1 tab.

  14. Strong linkage disequilibrium and haplotype analysis in Japanese pedigrees with Machado-Joseph disease

    SciTech Connect

    Endo, Kotaro; Tanaka, Hajime; Saito, Masaaki

    1996-09-20

    To identify the markers tightly linked to Machado-Joseph disease (MJD) and to investigate whether a limited number of ancestral chromosomes are shared by Japanese MJD pedigrees, a detailed linkage analysis employing D14S55, D14S48, D14S67, D14S291, D14S280, AFM343vf1, D14S81, D14S265, D14S62, and D14S65 was performed. The results of multipoint linkage analysis as well as detection of critical recombination events indicate that the gene for MJD is localized in a 4-cM region between D14S280-D14S81. We found strong linkage disequilibria at AFM343vf1 and D14S81, and association of a few common haplotypes with MJD. These results indicate that there is an obvious founder effect in Japanese MJD and suggest the possibility of the existence of predisposing haplotypes which are prone to expansions of CAG repeats. 47 refs., 3 figs., 2 tabs.

  15. War, sanity, and the Nazi mind: the last passion of Joseph Jastrow.

    PubMed

    Behrens, Peter J

    2009-11-01

    The career of Joseph Jastrow (1863-1944) spanned more than 50 years in service to psychology. For 40 years he represented academic psychology at the University of Wisconsin as chair of the psychology department (1886 to 1927), but also was never far from popularizing psychology through books, articles, public lectures, newspaper columns, and finally radio lectures (e.g., Jastrow, 1900, 1935b). Providing a scientific and progressive psychology for the general public was always a strong penchant for Jastrow on several subjects, such as spiritualism (Jastrow, 1911) and effective living (Jastrow, 1935b). About 1939, while he was well into his 70s, his efforts focused on exposing the menace that Adolf Hitler and Nazism posed, so he undertook to enlist prominent editors to publish his work, Hitler: Mask and Myth, as articles or a book. He was not successful in gaining support for the project. His failing can be understood from the perspectives of the American market for Hitler material, the shortcomings of the manuscript, and how he represented psychology to the American public. PMID:20509353

  16. Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer.

    PubMed

    Calongos, Giannina; Ogino, Mai; Kinuta, Takatoshi; Hori, Masateru; Mori, Tatsuo

    2016-01-01

    A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology. After surgery, the patient received chemotherapy with paclitaxel, carboplatin, and bevacizumab; however paclitaxel allergy was observed. As a result, chemotherapy continued with carboplatin and bevacizumab every three weeks for a total of 6 courses. Currently, she is still undergoing treatment with bevacizumab and CA125 levels have been progressively decreasing. SMJN is a rare umbilical metastasis which needs to be considered as a differential diagnosis in the presence of an umbilical tumor for prompt treatment initiation. PMID:27635270

  17. War, sanity, and the Nazi mind: the last passion of Joseph Jastrow.

    PubMed

    Behrens, Peter J

    2009-11-01

    The career of Joseph Jastrow (1863-1944) spanned more than 50 years in service to psychology. For 40 years he represented academic psychology at the University of Wisconsin as chair of the psychology department (1886 to 1927), but also was never far from popularizing psychology through books, articles, public lectures, newspaper columns, and finally radio lectures (e.g., Jastrow, 1900, 1935b). Providing a scientific and progressive psychology for the general public was always a strong penchant for Jastrow on several subjects, such as spiritualism (Jastrow, 1911) and effective living (Jastrow, 1935b). About 1939, while he was well into his 70s, his efforts focused on exposing the menace that Adolf Hitler and Nazism posed, so he undertook to enlist prominent editors to publish his work, Hitler: Mask and Myth, as articles or a book. He was not successful in gaining support for the project. His failing can be understood from the perspectives of the American market for Hitler material, the shortcomings of the manuscript, and how he represented psychology to the American public.

  18. Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine.

    PubMed

    Brown, M S; Goldstein, J L

    1996-02-01

    When Michael S. Brown, MD and Joseph L. Goldstein, MD first met as interns at the Massachusetts General Hospital in 1966, they could hardly have imagined that their careers would continue to be intertwined some 30 years later. It was shortly following their arrival as clinical associates at the National Institutes of Health in 1968 that the pair developed an interest in abnormalities of cholesterol metabolism. Bolstered by epidemiologic data that showed elevated cholesterol levels in many patients with myocardial infarction, Brown and Goldstein, who relocated to the University of Texas Southwestern Medical Center in 1972, began a search for receptors important in cholesterol homeostasis. These studies, performed in their early stages while juggling clinical duties at Parkland Hospital, culminated in a series of scientific achievements which merited among other honors the Hazen Award in 1982, the Lasker Award in 1985, and the Nobel Prize in Medicine in 1985. Today, as Regental Professors of the University of Texas, Brown and Goldstein head a laboratory group which continues to test the cutting edge of medical research. Although impressed with the pace of technological advances in biology, the declining role of clinically oriented physicians in biomedical research troubles the pair. Interviewed in their library in Dallas, Brown and Goldstein spoke about the complicated balance of science, medicine, and education necessary to produce another generation of successful investigators.

  19. Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.

    PubMed

    Esteves, Sofia; Duarte-Silva, Sara; Naia, Luana; Neves-Carvalho, Andreia; Teixeira-Castro, Andreia; Rego, Ana Cristina; Silva-Fernandes, Anabela; Maciel, Patrícia

    2015-01-01

    Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a compound with known neuroprotection activity, and previously shown to be effective in cell, fly and nematode models of MJD. We show that chronic VPA treatment in the CMVMJD135 mouse model had limited effects in the motor deficits of these mice, seen mostly at late stages in the motor swimming, beam walk, rotarod and spontaneous locomotor activity tests, and did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions. However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects, confirming target engagement. In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeutics. PMID:26505994

  20. Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer

    PubMed Central

    Ogino, Mai; Kinuta, Takatoshi; Hori, Masateru; Mori, Tatsuo

    2016-01-01

    A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology. After surgery, the patient received chemotherapy with paclitaxel, carboplatin, and bevacizumab; however paclitaxel allergy was observed. As a result, chemotherapy continued with carboplatin and bevacizumab every three weeks for a total of 6 courses. Currently, she is still undergoing treatment with bevacizumab and CA125 levels have been progressively decreasing. SMJN is a rare umbilical metastasis which needs to be considered as a differential diagnosis in the presence of an umbilical tumor for prompt treatment initiation. PMID:27635270

  1. Correlation between CAG Repeat Length and Clinical Features in Machado-Joseph Disease

    PubMed Central

    Maciel, Patrícia; Gaspar, Claudia; DeStefano, Anita L.; Silveira, Isabel; Coutinho, Paula; Radvany, João; Dawson, David M.; Sudarsky, Lewis; Guimarães, João; Loureiro, Jose E. L.; Nezarati, Marjan M.; Corwin, Lee I.; Lopes-Cendes, Iscia; Rooke, Karen; Rosenberg, Roger; MacLeod, Patrick; Farrer, Lindsay A.; Sequeiros, Jorge; Rouleau, Guy A.

    1995-01-01

    Machado-Joseph disease (MJD) is associated with the expansion of a CAG trinucleotide repeat in a novel gene on 14q32.1. We confirmed the presence of this expansion in 156 MJD patients from 33 families of different geographic origins: 15 Portuguese Azorean, 2 Brazilian, and 16 North American of Portuguese Azorean descent. Normal chromosomes contain between 12 and 37 CAG repeats in the MJD gene, whereas MJD gene carriers have alleles within the expanded range of 62–84 CAG units. The distribution of expanded alleles and the gap between normal and expanded allele sizes is either inconsistent with a premutation hypothesis or most (if not all) of the alleles we studied descend from a common ancestor. There is a strong correlation between the expanded repeat size and the age at onset of the disease as well as the clinical presentation. There is mild instability of the CAG tract length with transmission of the expanded alleles; both increase and decrease in size between parents and progeny occur, with larger variations in male than in female transmissions. Together, these effects can partly explain the variability of age at onset and of phenotypic features in MJD; however, other modifying factors must exist. ImagesFigure 3 PMID:7611296

  2. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2002 Annual Report.

    SciTech Connect

    Connor, Jason M.; McLellan, Jason G.; Butler, Chris

    2003-09-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  3. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2001 Annual Report.

    SciTech Connect

    Connor, Jason M.; McLellan, Jason G.; O'Connor, Dick

    2003-01-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power Planning Council (NPPC). The NPPC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPPC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area and the Columbia Basin Blocked Area Management Plan (1998

  4. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2002-2003 Annual Report.

    SciTech Connect

    Connor, Jason M.; McLellan, Jason G.; Butler, Chris

    2006-02-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  5. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2003-2004 Annual Report.

    SciTech Connect

    Connor, Jason M.; McLellan, Jason G.; Butler, Chris

    2005-11-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  6. Genetic counseling and presymptomatic testing programs for Machado-Joseph Disease: lessons from Brazil and Portugal

    PubMed Central

    Schuler-Faccini, Lavínia; Osorio, Claudio Maria; Romariz, Flavia; Paneque, Milena; Sequeiros, Jorge; Jardim, Laura Bannach

    2014-01-01

    Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most common form of spinocerebellar ataxia (SCA) worldwide. Diagnostic genetic testing is available to detect the disease-causing mutation by direct sizing of the CAG repeat tract in the ataxin 3 gene. Presymptomatic testing (PST) can be used to identify persons at risk of developing the disease. Genetic counseling provides patients with information about the disease, genetic risks, PST, and the decision-making process. In this study, we present the protocol used in PST for MJD and the relevant observations from two centers: Brazil (Porto Alegre) and Portugal (Porto). We provide a case report that illustrates the significant ethical and psychological issues related to PST in late-onset neurological disorders. In both centers, counseling and PST are performed by a multidisciplinary team, and genetic testing is conducted at the same institutions. From 1999 to 2012, 343 individuals sought PST in Porto Alegre; 263 (77%) of these individuals were from families with MJD. In Porto, 1,530 individuals sought PST between 1996 and 2013, but only 66 (4%) individuals were from families with MJD. In Brazil, approximately 50% of the people seeking PST eventually took the test and received their results, whereas 77% took the test in Portugal. In this case report, we highlight several issues that might be raised by the consultand and how the team can extract significant information. Literature about PST testing for MJD and other SCAs is scarce, and we hope this report will encourage similar studies and enable the implementation of PST protocols in other populations, mainly in Latin America. PMID:24764760

  7. Sir Joseph Barcroft, Cambridge placental and fetal research (1933-1966) and inter-generational Science.

    PubMed

    Boyd, Robert; Boyd, C A Richard

    2010-01-01

    The nature of Cambridge (UK) placental and fetal research in the middle third of the twentieth century is reviewed on the basis of published literature and personal recollection. Joseph Barcroft is a central figure who came to fetal research late in an extremely productive career which is briefly sketched. Contemporaneous Cambridge academics in the field included J.D. Boyd (the authors father), J. Hammond, F.H.A. Marshall, R.A. McCance, J. Needham, A.S. Parkes and Elsie Widdowson. The then current Cambridge academic geography is explained and features of its scientific life such as funding, institutional structure and ethos, teaching and clinical duties, domestic and gender roles, and political context, including war and empire, are briefly considered. The testing of research findings against general principles and use of quantitative thinking are identified as important features. Intergenerational connections, often within individual families, are identified as a striking feature. The long-term impact of Cambridge work of this period; locally, in current trophoblast and feto-placental genetic research, in Oxford in probably influencing G.S. Dawes research leadership, and internationally, especially through D.H. Barron, and through him to the Denver School, is considered. That human placental and embryological specimens collected by J.D. Boyd have received a new lease of life as the "Boyd Collection", including use by Allen Enders is noted. Mechanisms for the maintenance of scientific quality and productivity during the period, mainly through the scientist himself relying on an internalised sense of "obligation", are contrasted with those current in the UK and more widely; formal peer-review at frequent intervals, with subsequent allocation of short-term funding. The strengths and weaknesses of each are considered.

  8. Chief Joseph Kokanee Enhancement Project : Confederated Tribes of the Colville Reservaton 1997 Annual Report.

    SciTech Connect

    LeCaire, Richard

    1998-01-01

    In the early 1980's the Confederated Tribes of the Colville Reservation, the Spokane Tribe of Indians and the Washington Dept. of Fish and Wildlife developed a management plan for Lake Roosevelt on the restoration and enhancement of kokanee salmon populations using hatchery out plants and the restoration of natural spawning runs. The plan was incorporated into the Northwest Power Planning Council (NPPC) in their 1987 Columbia Basin Fish and Wildlife program as partial mitigation for hydropower caused fish losses resulting from the construction of Grand Coulee Dam. The Chief Joseph Kokanee Enhancement Project, as part of a basin wide effort, is evaluating the status of the natural production kokanee in streams tributary to Lakes Roosevelt and Rufus Woods and is examining entrainment through Grand Coulee Dam. The goal of this project is the protection and enhancement of the natural production kokanee in these two lakes. The project is currently collecting data under four phases or parts. Since 1991, Lake Whatcom Washington origin kokanee have been planted in considerable numbers into the waters of Lake Roosevelt. A natural production kokanee fishery has persisted in the lake since the early 1970's(Cash, 1995), (Scholz, 1991). Historical information alludes to wild Kokanee production in the San Poil River, Nespelem River, Big Sheep Creek, Ora-Pa-Ken Creek, Deep Creek and Onion Creeks. The genetic makeup of the fish within the fishery is unknown, as is their contribution to the fishery. The level of influence by the hatchery out planted stock on wild fish stocks is unknown as well. Project outcomes will indicate the genetic fitness for inclusion of natural production kokanee stocks into current Bonneville Power Administration funded hatchery programs. Other findings may determine contribution/interaction of/between wild/hatchery kokanee stocks found in the waters of Lake Franklin D. Roosevelt.

  9. Spinocerebellar ataxia type 3/Machado-Joseph disease starting before adolescence.

    PubMed

    Donis, Karina Carvalho; Saute, Jonas Alex Morales; Krum-Santos, Ana Carolina; Furtado, Gabriel Vasata; Mattos, Eduardo Preusser; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Jardim, Laura Bannach

    2016-04-01

    Onset of Machado-Joseph disease (SCA3/MJD) before adolescence has been rarely reported. This study aims to describe a cohort of SCA3/MJD with onset before 12 years of age, comparing their disease progression with the progression observed in patients with usual disease onset. We identified all cases from our cohort whose onset was before adolescence. After consent, patients were examined with clinical scales Scale for the Assessment and Rating of Ataxia (SARA) and Neurological Examination Score for Spinocerebellar Ataxia (NESSCA). Gender, age, age at onset, disease duration, CAG expanded repeats, transmitting parent, and anticipation of cases with infantile and adult onset were studied. Progression of NESSCA and SARA scores was estimated through a mixed model, and was compared with a historical group with onset after adolescence. Between 2000 and 2014, 461 symptomatic individuals from our region were diagnosed as SCA3/MJD. Onset of eight cases (2.2%), all heterozygotes, was before adolescence: seven were females (p = 0.054). CAG expanded repeats--75 ± 3 versus 84 ± 4--and anticipations--7 ± 9.7 versus 14.4 ± 7.2 years--were different between early childhood and adult onset groups (p < 0.03). The median survival of early childhood onset group was 23 years of age. The annual progression of SARA--2.3 and 0.6 points/year (p = 0.001)--and NESSCA--2.04 and 0.88 points/year (p = 0.043)--was faster in childhood than in adult onset group. Onset of SCA3/MJD before adolescence was related to larger expanded CAG repeats in heterozygosis; females seemed to be at higher risk. Disease progression was faster than in SCA3/MJD starting after 12 years.

  10. Cerebellar cognitive affective syndrome in Machado Joseph disease: core clinical features.

    PubMed

    Braga-Neto, Pedro; Pedroso, José Luiz; Alessi, Helena; Dutra, Lívia Almeida; Felício, André Carvalho; Minett, Thaís; Weisman, Patrícia; Santos-Galduroz, Ruth F; Bertolucci, Paulo Henrique F; Gabbai, Alberto Alain; Barsottini, Orlando Graziani Povoas

    2012-06-01

    The cerebellum is no longer considered a purely motor control device, and convincing evidence has demonstrated its relationship to cognitive and emotional neural circuits. The aims of the present study were to establish the core cognitive features in our patient population and to determine the presence of Cerebellar Cognitive Affective Syndrome (CCAS) in this group. We recruited 38 patients with spinocerebellar ataxia type 3 (SCA3) or Machado–Joseph disease (MJD)-SCA3/MJD and 31 controls. Data on disease status were recorded (disease duration, age, age at onset, ataxia severity, and CAG repeat length). The severity of cerebellar symptoms was measured using the International Cooperative Ataxia Rating Scale and the Scale for the Assessment and Rating of Ataxia. The neuropsychological assessment consisted of the Mini-Mental State Examination, Clock Drawing Test, Wechsler Adult Intelligence Scale, Rey–Osterrieth Complex Figure, Wisconsin Card Sorting Test, Stroop Color–Word Test, Trail-Making Test, Verbal Paired Associates, and verbal fluency tests. All subjects were also submitted to the Hamilton Anxiety Scale and Beck Depression Inventory. After controlling for multiple comparisons, spatial span, picture completion, symbol search, Stroop Color–Word Test, phonemic verbal fluency, and Trail-Making Tests A and B were significantly more impaired in patients with SCA3/MJD than in controls. Executive and visuospatial functions are impaired in patients with SCA3/MJD, consistent with the symptoms reported in the CCAS. We speculate on a possible role in visual cortical processing degeneration and executive dysfunction in our patients as a model to explain their main cognitive deficit. PMID:21975858

  11. Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.

    PubMed

    Matos, Carlos A; de Macedo-Ribeiro, Sandra; Carvalho, Ana Luísa

    2011-09-15

    Polyglutamine (polyQ) diseases are a group of nine neurodegenerative disorders caused by an unstable CAG expansion in the codifying region of their respective associated genes. However, each polyQ disease displays a different symptomatic and pathoanatomic profile and the proteins involved share no homology outside the polyQ tract. This suggests that the other regions of the proteins and the cellular functions they mediate are important in defining disease progression and specificity. Machado-Joseph disease (MJD), the most common form of spinocerebellar ataxia worldwide, is a progressive and ultimately fatal neurodegenerative disorder caused by polyQ expansion in ataxin-3 (atx3), a conserved and ubiquitous protein known to bind polyubiquitin chains and to function as a deubiquitinating enzyme. Atx3 has been linked to protein homeostasis maintenance, transcription, cytoskeleton regulation and myogenesis, but its precise biologic function remains a mystery, limiting the understanding of the mechanisms by which the mutated protein leads to the selective neuronal death profile observed in MJD patients. A number of recent evidence support the idea that the toxic entities behind neuronal demise may be either the dysfunctional expanded atx3 or the soluble amyloid-like oligomers formed by self-assembly of the aggregation-prone mutated protein. Expanded atx3 pathogenicity is likely the result of a series of events implicating both atx3 dysfunction and aggregation, possibly involving both full-length atx3 and polyQ-containing fragments that may act as seeds for protein aggregation. A deeper understanding of polyQ protein biology, the way the expansion alters their features, and the consequences of these changes for cell functioning and survival are sure to be of critical importance for developing future treatment of polyQ diseases.

  12. [An autopsied case of type 2 Machado-Joseph's disease or spino-pontine degeneration].

    PubMed

    Iwabuchi, K; Nagatomo, H; Tanabe, T; Sakai, H; Yagishita, S

    1993-08-01

    The authors present the clinico-pathological findings in a member of a family residing in Akita Prefecture located in the north-eastern region of Japan. Four members in three generations of the family developed ataxia. The autopsied patient was a 42-year-old woman, who, at the age of 25, had developed progressive cerebellar ataxia with pyramidal spasticity and increased deep tendon reflexes predominant in the lower extremities. However, she retained fine movement of the hands and fingers and showed no dysarthria until the age of 35. She could no longer walk unassisted at 38 years old. She showed cerebellar ataxia in both hands and legs, dysarthria, bulging eyes, progressive extraoculomotor palsy with nystagmus, bradykinesia, sensory disturbance, and dystonia in the face, upper extremities, and fingers. Deep tendon reflexes were decreased, especially in the lower extremities. Subacute generalized muscular atrophy developed at the age of 39. She became bedridden and died of pneumonia. The clinical diagnosis was Type-2 of the entity known in Japan as Machado-Joseph disease. At neuropathological examination, the brain weight was 1,250 g. The spinocerebellar system including Clarke's column and the spinocerebellar tracts were degenerated, but the cerebellar cortex and inferior olivary nucleus were spared. Slight-to-moderate degeneration was observed in the pontocerebellar system. In the dentate nucleus, most of the neurons showed what is known in Japan as "grumose degeneration", but there was no neuronal loss or gliosis. The hilus of the dentate nucleus and the superior cerebellar peduncle were intact.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Ataxin-3 and Its E3 Partners: Implications for Machado–Joseph Disease

    PubMed Central

    Durcan, Thomas M.; Fon, Edward A.

    2013-01-01

    Machado–Joseph disease (MJD) is the most common dominant inherited ataxia worldwide, caused by an unstable CAG trinucleotide expansion mutation within the SCA3 gene resulting in an expanded polyglutamine tract within the ataxin-3 protein. Ataxin-3 functions as a deubiquitinating enzyme (DUB), within the Ub system and whilst many DUBs are known to partner with and deubiquitinate specific E3-Ub ligases, ataxin-3 had no identified E3 partner until recent studies implicated parkin and CHIP, two neuroprotective E3 ligases. MJD often presents with symptoms of Parkinson disease (PD), which led to identification of parkin as a novel E3-Ub ligase whose activity was regulated by ataxin-3-mediated deubiquitination. Findings from these studies also revealed an unexpected convergence upon the E2-Ub-conjugating enzyme in the regulation of an E3/DUBenzyme pair. Moreover, mutant but not wild-type ataxin-3 promotes the clearance of parkin via the autophagy pathway, raising the intriguing possibility that increased turnover of parkin may contribute to the pathogenesis of MJD and help explain some of the Parkinsonian features in MJD. In addition to parkin, the U-box E3 ligase CHIP, a neuroprotective E3 implicated in protein quality control, was identified as a second E3 partner of ataxin-3, with ataxin-3 regulating the ability of CHIP to ubiquitinate itself. Indeed, ataxin-3 not only deubiquitinated CHIP, but also trimmed Ub conjugates on CHIP substrates, thereby regulating the length of Ub chains. Interestingly, when expanded ataxin-3 was present, CHIP levels were also reduced in the brains of MJD transgenic mice, raising the possibility that loss of one or both E3 partners may be a contributing factor in the pathogenesis of SCA3. In this review we discuss the implications from these studies and describe the importance of these findings in helping us understand the molecular processes involved in SCA3 and other neurodegenerative disorders. PMID:23653622

  14. Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

    PubMed Central

    Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira

    2013-01-01

    Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly-inherited neurodegenerative disorder caused by the over-repetition of a CAG codon in the MJD1 gene. This expansion translates into a polyglutamine tract that confers a toxic gain-of-function to the mutant protein – ataxin-3, leading to neurodegeneration in specific brain regions, with particular severity in the cerebellum. No treatment able to modify the disease progression is available. However, gene silencing by RNA interference has shown promising results. Therefore, in this study we investigated whether lentiviral-mediated allele-specific silencing of the mutant ataxin-3 gene, after disease onset, would rescue the motor behavior deficits and neuropathological features in a severely impaired transgenic mouse model of MJD. For this purpose, we injected lentiviral vectors encoding allele-specific silencing-sequences (shAtx3) into the cerebellum of diseased transgenic mice expressing the targeted C-variant of mutant ataxin-3 present in 70% of MJD patients. This variation permits to discriminate between the wild-type and mutant forms, maintaining the normal function of the wild-type allele and silencing only the mutant form. Quantitative analysis of rotarod performance, footprint and activity patterns revealed significant and robust alleviation of gait, balance (average 3-fold increase of rotarod test time), locomotor and exploratory activity impairments in shAtx3-injected mice, as compared to control ones injected with shGFP. An important improvement of neuropathology was also observed, regarding the number of intranuclear inclusions, calbindin and DARPP-32 immunoreactivity, fluorojade B and Golgi staining and molecular and granular layers thickness. These data demonstrate for the first time the efficacy of gene silencing in blocking the MJD-associated motor-behavior and neuropathological abnormalities after the onset of the disease, supporting the use of this strategy

  15. From Dodge City to Emerald City: The Importance of Joseph E. Zins' Work in Teacher Education Programs--A Commentary on "The Scientific Base Linking Social and Emotional Learning to School Success," a Chapter by Joseph E. Zins, Michelle R. Bloodworth, Roger P. Weissberg, and Herbert J. Walberg

    ERIC Educational Resources Information Center

    Carlson, David Lee

    2007-01-01

    This commentary argues that Joseph Zins' work can contribute and enhance university-based teacher preparation programs. Focusing on secondary English Education, it examines how SEL competencies can improve the curricula and field experiences to support pre-service teachers.

  16. Medicine and music: a note on John Hunter (1728-93) and Joseph Haydn (1732-1809).

    PubMed

    Fu, Louis

    2010-05-01

    Joseph Haydn was a central figure in the development and growth of the European classical musical tradition in its transition from the Baroque period. John Hunter as the Founder of Scientific Surgery was a dominant figure in 18th-century British medical science. Anne Hunter née Home (1742-1821) was in her own right a figure of some eminence in the literary circles of 18th-century London. Attracted to the burgeoning medical and musical scenes of London, John Hunter married Anne Home and became a famous surgeon; Haydn became acquainted with the Hunters. The people, the opportunities and the circumstances had coincided. PMID:20519713

  17. Medicine and music: a note on John Hunter (1728-93) and Joseph Haydn (1732-1809).

    PubMed

    Fu, Louis

    2010-05-01

    Joseph Haydn was a central figure in the development and growth of the European classical musical tradition in its transition from the Baroque period. John Hunter as the Founder of Scientific Surgery was a dominant figure in 18th-century British medical science. Anne Hunter née Home (1742-1821) was in her own right a figure of some eminence in the literary circles of 18th-century London. Attracted to the burgeoning medical and musical scenes of London, John Hunter married Anne Home and became a famous surgeon; Haydn became acquainted with the Hunters. The people, the opportunities and the circumstances had coincided.

  18. Surgical pathology in the era of the Civil War: the remarkable life and accomplishments of Joseph Janvier Woodward, MD.

    PubMed

    Rapkiewicz, Amy V; Hawk, Alan; Noe, Adrienne; Berman, David M

    2005-10-01

    Joseph Janvier Woodward was an assistant surgeon in the US Army during the Civil War, coauthored the definitive works on the mortality and morbidity of that war, attended at the autopsy of President Lincoln, and attended President Garfield after he was shot. He revolutionized the field of photomicroscopy and was one of the first pathologists to use aniline dyes as tissue stains. Yet despite the occasional biographical sketch every few decades, he is largely unknown today. Herein, we review his contributions to surgical pathology and medicine and present modern-day photomicrographs of 140-year-old slides from Woodward's original collection. PMID:16196522

  19. Franz Joseph Gall on greatness in the fine arts: A collaboration of multiple cortical faculties of mind.

    PubMed

    Eling, Paul; Finger, Stanley

    2015-10-01

    Although Franz Joseph Gall (1758-1828) is well known for his organology, i.e., his theory of cortical localization of function largely derived from skull features, little has been written about his ideas pertaining to specific faculties other than speech, and even less attention has been drawn to how the individual faculties might work together in specific situations. Our focus shall be on how Franz Joseph Gall viewed the fine arts, with special emphasis on what one must possess to be outstanding in this field, which he associated with perceiving and understanding relationships, and several higher faculties of mind, including color, "constructiveness," locality, and recognizing people. How these faculties are utilized, he tells us, will vary with whether an artist does portraits, landscapes, historical scenes, still life compositions, etc., as well as with the selected medium (e.g., oil paints, sketching on paper, stones to be carved). To put Gall's thoughts about the fine arts in context, brief mention will be made of his scientific career, his guiding philosophy, the questions he most wanted to answer, what he construed as "evidence," how he eliminated the soul or "controller" from his system, and how he presented his work to the public. Some comparisons will be made to what he wrote about having a talent for music. PMID:26188788

  20. Joseph Priestley across Theology, Education, and Chemistry: An Interdisciplinary Case Study in Epistemology with a Focus on the Science Education Context

    ERIC Educational Resources Information Center

    de Berg, Kevin C.

    2011-01-01

    This paper discusses the findings of a search for the intellectual tools used by Joseph Priestley (1733-1804) in his chemistry, education, and theology documents. Priestley's enquiring democratic view of knowledge was applicable in all three areas and constitutes a significant part of his lifework. Current epistemological issues in science…

  1. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west...

  2. The Chicago Board of Education Desegregation Policies and Practices [1975-1985]: A Historical Examination of the Administrations of Superintendents Dr. Joseph P. Hannon and Dr. Ruth Love

    ERIC Educational Resources Information Center

    James, Michael

    2009-01-01

    The purpose of this study will be to examine the policies and practices of two distinguished superintendents of the Chicago Public Schools: Dr. Joseph P. Hannon and the first African American female Superintendent Dr. Ruth Love. Hannon's four year administration extended from 1975 through 1979. Love's administration encompassed the years 1980…

  3. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west...

  4. Telegram from Senator Joseph McCarthy to President Harry S. Truman. The Constitution Community: Postwar United States (1945 to Early 1970s).

    ERIC Educational Resources Information Center

    Gray, Tom

    As soon as World War II ended, the United States and the Soviet Union began a struggle for supremacy. It was against the backdrop of the Cold War that the threat of internal subversion and external attack began to preoccupy Congress. On February 9, 1950, Senator Joseph McCarthy gave a speech in Wheeling, West Virginia, where he claimed to have in…

  5. Close but No Cigar (Yet): A Commentary on "Has Consultation Achieved Its Primary Prevention Potential?," an Article by Joseph E. Zins

    ERIC Educational Resources Information Center

    Love, Kelly Brey

    2007-01-01

    More than a decade ago, Joseph Zins (1995) hypothesized that consultation had the power to prevent children from developing academic, social, emotional, and related problems. To date, empirical research has yet to fully validate its value. This commentary discusses the potential benefit of consultation as a preventive measure, identifies ways to…

  6. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    NASA Astrophysics Data System (ADS)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  7. The role of the patient's remembered history and unconscious past in the evolution of Betty Joseph's 'Here and now' clinical technique (1959-1989).

    PubMed

    Aguayo, Joseph

    2011-10-01

    The author historicizes one aspect of Betty Joseph's ongoing technical contributions in terms of its originating London kleinian context. Early on she drew upon both the patient's remembered history and unconscious past, linking these experiences in past-to-present transference interpretations in order to effect psychic change. In evolving the technique of 'here and now' analysis, Joseph came to emphasize a communicative definition of projective and introjective identification as well as the significance of enactments while marginalizing the use of part-object anatomical interpretative language. She gradually set aside directly linking the patient's past with the present, compelled now by making direct contact with her patients. She now tracked how difficult patients acted in and responded to interpretations from moment to moment. The author maintains that the explicit and implicit conceptual work of Wilfred Bion as well as Joseph's continuous group workshop for analysts led to an increased understanding of the patient's projective impact on the analyst's countertransference responses, and thereby increased the analyst's capacity with 'difficult to treat' narcissistic spectrum patients described by her colleague, Herbert Rosenfeld. In recent work, while Joseph continues to elucidate what patients recall about their early past, she formats her understanding in terms of a direct analysis of the structure of the patient's projected internal object relations in the transference. The analyst works with the patient's communications and enactments, with a greater emphasis on a more 'inside-to-outside' understanding of transference in contrast to the earlier 'past-to-present' work associated with both Freud and Klein. This investigation concludes with one example of Betty Joseph's significant impact on contemporary kleinian technique by taking up some of Michael Feldman's work. Now the analyst listens to the 'past presented,' the patient's projected internal world, as well

  8. Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

    PubMed Central

    Cunha-Santos, Janete; Duarte-Neves, Joana; Carmona, Vitor; Guarente, Leonard; Pereira de Almeida, Luís; Cavadas, Cláudia

    2016-01-01

    Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression. In this study we find that caloric restriction dramatically rescues the motor incoordination, imbalance and the associated neuropathology in transgenic MJD mice. We further show that caloric restriction rescues SIRT1 levels in transgenic MJD mice, whereas silencing SIRT1 is sufficient to prevent the beneficial effects on MJD pathology. In addition, the re-establishment of SIRT1 levels in MJD mouse model, through the gene delivery approach, significantly ameliorates neuropathology, reducing neuroinflammation and activating autophagy. Furthermore, the pharmacological activation of SIRT1 with resveratrol significantly reduces motor incoordination of MJD mice. The pharmacological SIRT1 activation could provide important benefits to treat MJD patients. PMID:27165717

  9. A question of merit: John Hutton Balfour, Joseph Hooker and the 'concussion' over the Edinburgh chair of botany.

    PubMed

    Bellon, Richard

    2005-03-01

    In 1845, Robert Graham's death created a vacancy for the traditionally dual appointment to the University of Edinburgh's chair of botany and the Regius Keepership of the Edinburgh Royal Botanic Garden. John Hutton Balfour and Joseph Hooker emerged as the leading candidates. The contest quickly became embroiled in long running controversies over the nature and control of Scottish university education at a time of particular social and political tension after a recent schism in Church of Scotland. The politics of the appointment were complicated by the fact that the Edinburgh Town Council (which preferred Balfour) chose the chair while the keepership was under the patronage of the Westminster government (which preferred Hooker). Balfour eventually emerged triumphant after a bitter campaign marked on all sides by intense politicking. The struggle to replace Graham provides a case study in how Victorian men of science adapted their aspirations to the practical realities of life in industrial, reforming, imperial, multinational Britain.

  10. 'God grant it may do good two all': the madhouse practice of Joseph Mason, 1738-79.

    PubMed

    Smith, Leonard

    2016-06-01

    Private madhouses made a significant contribution to the development of psychiatric practices in eighteenth-century England. Joseph Mason of Bristol, proprietor of a madhouse at Stapleton and then at nearby Fishponds, was part of a dynasty of successful and respected mad-doctors. A deeply religious man, his Christian ethics constituted the guiding force in his work with patients and interactions with their relatives. He was also an astute man of business, who recognized that comfortable domestic surroundings and the achievement of recoveries would enhance his reputation and attract lucrative middle-class custom. His treatment approaches, illustrated in a 1763 diary, were eclectic and pragmatic, comprising various medicines, dietary regulation, graded social interactions, and the cultivation of individualized therapeutic relationships with his patients. PMID:26837815

  11. 'God grant it may do good two all': the madhouse practice of Joseph Mason, 1738-79.

    PubMed

    Smith, Leonard

    2016-06-01

    Private madhouses made a significant contribution to the development of psychiatric practices in eighteenth-century England. Joseph Mason of Bristol, proprietor of a madhouse at Stapleton and then at nearby Fishponds, was part of a dynasty of successful and respected mad-doctors. A deeply religious man, his Christian ethics constituted the guiding force in his work with patients and interactions with their relatives. He was also an astute man of business, who recognized that comfortable domestic surroundings and the achievement of recoveries would enhance his reputation and attract lucrative middle-class custom. His treatment approaches, illustrated in a 1763 diary, were eclectic and pragmatic, comprising various medicines, dietary regulation, graded social interactions, and the cultivation of individualized therapeutic relationships with his patients.

  12. Response of the St. Joseph River to lake level changes during the last 12,000 years in the Lake Michigan basin

    USGS Publications Warehouse

    Kincare, K.A.

    2007-01-01

    The water level of the Lake Michigan basin is currently 177 m above sea level. Around 9,800 14C years B.P., the lake level in the Lake Michigan basin had dropped to its lowest level in prehistory, about 70 m above sea level. This low level (Lake Chippewa) had profound effects on the rivers flowing directly into the basin. Recent studies of the St. Joseph River indicate that the extreme low lake level rejuvenated the river, causing massive incision of up to 43 m in a valley no more than 1.6 km wide. The incision is seen 25 km upstream of the present shoreline. As lake level rose from the Chippewa low, the St. Joseph River lost competence and its estuary migrated back upstream. Floodplain and channel sediments partially refilled the recently excavated valley leaving a distinctly non-classical morphology of steep sides with a broad, flat bottom. The valley walls of the lower St. Joseph River are 12-18 m tall and borings reveal up to 30 m of infill sediment below the modern floodplain. About 3 ?? 108 m3 of sediment was removed from the St. Joseph River valley during the Chippewa phase lowstand, a massive volume, some of which likely resides in a lowstand delta approximately 30 km off-shore in Lake Michigan. The active floodplain below Niles, Michigan, is inset into an upper terrace and delta graded to the Calumet level (189 m) of Lake Chicago. In the lower portion of the terrace stratigraphy a 1.5-2.0 m thick section of clast-supported gravel marks the entry of the main St. Joseph River drainage above South Bend, Indiana, into the Lake Michigan basin. This gravel layer represents the consolidation of drainage that probably occurred during final melting out of ice-marginal kettle chains allowing stream piracy to proceed between Niles and South Bend. It is unlikely that the St. Joseph River is palimpsest upon a bedrock valley. The landform it cuts across is a glaciofluvial-deltaic feature rather than a classic unsorted moraine that would drape over pre-glacial topography

  13. Public health assessment for petitioned public health assessment, Union Carbide (Byers Warehouse), St. Joseph, Buchanan County, Missouri, Region 7. Final report

    SciTech Connect

    Not Available

    1993-05-04

    In response to a petition from a St. Joseph, Missouri resident, the Agency for Toxic Substances and Disease Registry (ATSDR) conducted a public health assessment of the Union Carbide (Byers Warehouse) site in St. Joseph, Missouri. The basement of Byers Warehouse was used by Vulcan Chemicals to store ethylene dibromide (EDB), chloroform, and carbon tetrachloride (CCI4). The first and second floors were used by Union Carbide to store 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 2,4-dichlorophenoxyacetic acid (2,4-D), and 2,4,5-trichlorophenoxyproprionic acid (2,4,5-TP). The Byers Warehouse (Union Carbide) Petition site is not a current public health hazard. That conclusion is based on the complete removal of the toxic substances stored in the warehouse, and the lack of any current or future completed exposure pathways. Past storage of herbicides and other chemical products represented a public health hazard.

  14. "If I only touch her cloak": the Sisters of Charity of St. Joseph in New Orleans hospital, 1834-1860.

    PubMed

    Kong, Hyejung Grace; Kim, Ock-Joo

    2015-04-01

    This study is about the Sisters of Charity of St. Joseph in New Orleans' Charity Hospital during the years between 1834 and 1860. The Sisters of Charity of St. Joseph was founded in 1809 by Saint Elizabeth Ann Bailey Seton (first native-born North American canonized in 1975) in Emmitsburg, Maryland. Seton's Sisters of Charity was the first community for religious women to be established in the United States and was later incorporated with the French Daughters of Charity of St. Vincent de Paul in 1850. A call to work in New Orleans' Charity Hospital in the 1830s meant a significant achievement for the Sisters of Charity, since it was the second oldest continuously operating public hospitals in the United States until 2005, bearing the same name over the decades. In 1834, Sister Regina Smith and other sisters were officially called to Charity Hospital, in order to supersede the existing "nurses, attendants, and servants," and take a complete charge of the internal management of Charity Hospital. The existing scholarship on the history of hospitals and Catholic nursing has not integrated the concrete stories of the Sisters of Charity into the broader histories of institutionalized medicine, gender, and religion. Along with a variety of primary sources, this study primarily relies on the Charity Hospital History Folder stored at the Daughters of Charity West Center Province Archives. Located in the "Queen city of the South," Charity Hospital was the center of the southern medical profession and the world's fair of people and diseases. Charity Hospital provided the sisters with a unique situation that religion and medicine became intertwined. The Sisters, as nurses, constructed a new atmosphere of caring for patients and even their families inside and outside the hospital, and built their own separate space within the hospital walls. As hospital managers, the Sisters of Charity were put in complete charge of the hospital, which was never seen in other hospitals. By

  15. Atrazine concentrations in stream water and streambed sediment pore water in the St. Joseph and Galien River basins, Michigan and Indiana, May 2001-September 2003

    USGS Publications Warehouse

    Duris, Joseph W.; Reeves, Howard W.; Kiesler, James L.

    2005-01-01

    The U.S. Geological Survey (USGS) sampled multiple stream sites across the St. Joseph and Galien River Basins to detect and quantify the herbicide atrazine using a field enzyme-linked immunosorbent assay (ELISA) triazine test. In May 2001, July 2001, April 2002, August 2002, August 2003 and September 2003, composite samples were collected across streams at USGS streamflow-gaging stations. Concentrations and instantaneous loading for atrazine sampled in stream water throughout the St. Joseph River and Galien River Basins in Michigan and Indiana ranged from nondetection (< 0.05 part per billion (ppb)) with an associated load less than 0.001 kilogram per day (kg/d) to 6 ppb and a maximum load of 10 kg/d. Atrazine concentrations were highest in May 2001 just after the planting season. The lowest concentration was found in April 2002 just before planting. Atrazine concentrations in streambed-sediment pore water were not spatially connected with atrazine concentrations in stream-water samples. This study showed that atrazine concentrations were elevated from May to July in the St. Joseph and Galien River Basins. At many sites, concentrations exceeded the level that has been shown to feminize frog populations (0.2 ppb). There were 8 sites where concentrations exceeded 0.2 ppb atrazine in May 2001 and July 2001.

  16. Joseph A. Burton Forum Award Talk: Remembering our Humanity: the deep impact of the Russell-Einstein Manifesto

    NASA Astrophysics Data System (ADS)

    Lewis, Patricia M.

    2009-05-01

    ``There lies before us, if we choose, continual progress in happiness, knowledge, and wisdom. Shall we, instead, choose death, because we cannot forget our quarrels? We appeal as human beings to human beings: Remember your humanity, and forget the rest.'' Days before his death, Albert Einstein joined Bertrand Russell and other notable scientists and philosophers in issuing a statement calling for the abolition of war and for governments to ``find peaceful means for the settlement of all matters of dispute between them." As a first step, they called for the renunciation of nuclear weapons. The initiative led to the establishment of the Pugwash Conferences on Science and World Affairs, which bring together influential scholars and public figures concerned with reducing the danger of armed conflict and seeking cooperative solutions for global problems. The Russell-Einstein Manifesto has had a major impact on the way in which people discuss the issues of peace and war. The paper traces the growing awareness of the meaning of war, ways in which violent conflict can be prevented, particularly in the nuclear age, and the humanitarian imperative for so doing. From the Russell-Einstein Manifesto, London, 9 July 1955, signed also by Max Born, Percy W. Bridgman, Leopold Infeld, Frederic Joliot-Curie, Herman J. Muller, Linus Pauling, Cecil F. Powell, Joseph Rotblat and Hideki Yukawa

  17. An innovative model of diabetes care and delivery: the St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP).

    PubMed

    Reichert, Sonja M; Harris, Stewart; Harvey, Betty

    2014-06-01

    The majority of diabetes care in Canada is provided within the primary healthcare setting. It is delivered in a variety of models ranging from the physician working in a solo fee-for-service practice to an interprofessional team setting with specialist collaboration. To augment diabetes-related health services, the Ontario government has provided substantial funding to support community diabetes education programs. These models and initiatives are improving diabetes outcomes, and continued evolution of these programs can provide even greater outcomes. The St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP) is an innovative model that incorporates multidisciplinary allied health professionals together with physician support to provide care for more than 3000 patients in London, Ontario, Canada. It embodies the Canadian Diabetes Association (CDA)'s Organizations of Care recommendations to combine patient education and self-management with active medical support at each clinic encounter, all while embodying the tenets of primary care. A brief review of primary healthcare reform is provided to explain how the SJHC PCDSP combines features of current models in a unique format so as to deliver exceptional patient care. By providing a detailed description of the services delivered at the SJHC PCDSP, it is hoped that both specialists and primary care providers consider using and adapting approaches to diabetes management based on this innovative model to optimize their practices. PMID:24909092

  18. Joseph S. Weiner and the foundation of post-WW II human biology in the United Kingdom.

    PubMed

    Little, Michael A; Collins, Kenneth J

    2012-01-01

    Both the United States and the United Kingdom experienced a transformation in the science of physical anthropology from the period before World War II until the post-war period. In the United States, Sherwood L. Washburn is credited with being a leading figure in this transformation. In the United Kingdom, two individuals were instrumental in bringing about a similar change in the profession. These were Joseph S. Weiner at the University of Oxford and Nigel Barnicot at the University of London, with Weiner playing the principal role as leader in what Washburn called the "New Physical Anthropology," that is, the application of evolutionary theory, the de-emphasis on race classification, and the application of the scientific method and experimental approaches to problem solving. Weiner's contributions to physical anthropology were broad-based--climatic and work physiology, paleoanthropology, and human variation--in what became known as human biology in the U.K. and human adaptability internationally. This biographical essay provides evidence for the significant influence of J.S. Weiner on the post-war development of human biology (biological or physical anthropology) inthe U.K. PMID:23124506

  19. Spinocerebellar ataxia type 3/Machado-Joseph disease: segregation patterns and factors influencing instability of expanded CAG transmissions.

    PubMed

    Souza, G N; Kersting, N; Krum-Santos, A C; Santos, A S P; Furtado, G V; Pacheco, D; Gonçalves, T A; Saute, J A; Schuler-Faccini, L; Mattos, E P; Saraiva-Pereira, M L; Jardim, L B

    2016-08-01

    Controversies about Mendelian segregation and CAG expansion (CAGexp) instabilities during meiosis in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) need clarification. Additional evidence about these issues was obtained from the cohort of all SCA3/MJD individuals living in South Brazil. A survey was carried out to update information registered since 2001. Deaths were checked with the Public Information System, and data was made anonymous. Anticipation and delta-CAGexp from parent-offspring pairs, and delta-CAGexp between siblings were obtained. One hundred and fifty-nine families (94% of the entire registry) were retrieved, comprising 3725 living individuals as of 2015, 625 of these being symptomatic. Minimal prevalence was 6:100,000. Carriers of a CAGexp represented 65.6% of sibs in the genotyped offspring (p < 0.001). Median instability was larger among paternal than maternal transmissions, and instabilities correlated with anticipation (r = 0.38; p = 0.001). Age of the parent correlated to delta-CAGexp among 115 direct parent-offspring CAGexp transmissions (ρ = 0.23, p = 0.014). In 98 additional kindreds, the delta-CAGexp between 269 siblings correlated with their delta-of-age (ρ = 0.27, p < 0.0001). SCA3/MJD was associated with a segregation distortion favoring the expanded allele in our cohort. Instability of expansion during meiosis was weakly influenced by the age of the transmitting parent at the time of conception. PMID:26693702

  20. Moral absolutism and the double-effect exception: reflections on Joseph Boyle's Who is entitled to double effect?

    PubMed

    Donagan, A

    1991-10-01

    Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human goods may not be intentionally violated, cannot dispense with such exceptions, although he rightly rejects some widely held views about what they are. By contrast, Kantian absolutist theory, which derives from the principle that lawful freedom must not be violated, has a corollary--that it is a duty, where possible, to coerce those who try to violate lawful freedom--which makes superfluous many of the double-effect exceptions Boyle allows. Other implications of the two theories are contrasted. Inter alia, it is argued that, in Boyle's theory, that a violation of a fundamental human good can be viewed as a cost proportionate to a benefit obtained, cannot yield a double-effect exception to the prohibition of intentionally violating that good, because paying a cost cannot be unintentional.

  1. Moral absolutism and the double-effect exception: reflections on Joseph Boyle's Who is entitled to double effect?

    PubMed

    Donagan, A

    1991-10-01

    Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human goods may not be intentionally violated, cannot dispense with such exceptions, although he rightly rejects some widely held views about what they are. By contrast, Kantian absolutist theory, which derives from the principle that lawful freedom must not be violated, has a corollary--that it is a duty, where possible, to coerce those who try to violate lawful freedom--which makes superfluous many of the double-effect exceptions Boyle allows. Other implications of the two theories are contrasted. Inter alia, it is argued that, in Boyle's theory, that a violation of a fundamental human good can be viewed as a cost proportionate to a benefit obtained, cannot yield a double-effect exception to the prohibition of intentionally violating that good, because paying a cost cannot be unintentional. PMID:1779209

  2. Spinocerebellar ataxia type 3/Machado-Joseph disease: segregation patterns and factors influencing instability of expanded CAG transmissions.

    PubMed

    Souza, G N; Kersting, N; Krum-Santos, A C; Santos, A S P; Furtado, G V; Pacheco, D; Gonçalves, T A; Saute, J A; Schuler-Faccini, L; Mattos, E P; Saraiva-Pereira, M L; Jardim, L B

    2016-08-01

    Controversies about Mendelian segregation and CAG expansion (CAGexp) instabilities during meiosis in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) need clarification. Additional evidence about these issues was obtained from the cohort of all SCA3/MJD individuals living in South Brazil. A survey was carried out to update information registered since 2001. Deaths were checked with the Public Information System, and data was made anonymous. Anticipation and delta-CAGexp from parent-offspring pairs, and delta-CAGexp between siblings were obtained. One hundred and fifty-nine families (94% of the entire registry) were retrieved, comprising 3725 living individuals as of 2015, 625 of these being symptomatic. Minimal prevalence was 6:100,000. Carriers of a CAGexp represented 65.6% of sibs in the genotyped offspring (p < 0.001). Median instability was larger among paternal than maternal transmissions, and instabilities correlated with anticipation (r = 0.38; p = 0.001). Age of the parent correlated to delta-CAGexp among 115 direct parent-offspring CAGexp transmissions (ρ = 0.23, p = 0.014). In 98 additional kindreds, the delta-CAGexp between 269 siblings correlated with their delta-of-age (ρ = 0.27, p < 0.0001). SCA3/MJD was associated with a segregation distortion favoring the expanded allele in our cohort. Instability of expansion during meiosis was weakly influenced by the age of the transmitting parent at the time of conception.

  3. An innovative model of diabetes care and delivery: the St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP).

    PubMed

    Reichert, Sonja M; Harris, Stewart; Harvey, Betty

    2014-06-01

    The majority of diabetes care in Canada is provided within the primary healthcare setting. It is delivered in a variety of models ranging from the physician working in a solo fee-for-service practice to an interprofessional team setting with specialist collaboration. To augment diabetes-related health services, the Ontario government has provided substantial funding to support community diabetes education programs. These models and initiatives are improving diabetes outcomes, and continued evolution of these programs can provide even greater outcomes. The St. Joseph's Primary Care Diabetes Support Program (SJHC PCDSP) is an innovative model that incorporates multidisciplinary allied health professionals together with physician support to provide care for more than 3000 patients in London, Ontario, Canada. It embodies the Canadian Diabetes Association (CDA)'s Organizations of Care recommendations to combine patient education and self-management with active medical support at each clinic encounter, all while embodying the tenets of primary care. A brief review of primary healthcare reform is provided to explain how the SJHC PCDSP combines features of current models in a unique format so as to deliver exceptional patient care. By providing a detailed description of the services delivered at the SJHC PCDSP, it is hoped that both specialists and primary care providers consider using and adapting approaches to diabetes management based on this innovative model to optimize their practices.

  4. Effects of agricultural irrigation on water resources in the St. Joseph River basin, Indiana, and implications for aquifer yield

    USGS Publications Warehouse

    Peters, J.G.; Renn, D.E.

    1988-01-01

    During the past decade, the acreage of irrigated agricultural land in Indiana has tripled, causing public concern about competition for water and resulting in several State laws for regulating water withdrawals. The St. Joseph River basin represents less than one-tenth of the area of the State, but it contains one-third of the State 's irrigated land. Irrigated land in the basin is composed of permeable soils that are underlain by productive glacial aquifers. A computer model was used to analyze the effects of maximum irrigation withdrawals on aquifer drawdown and streamflow in a 16.5 sq mi area of intensive irrigation. Simulation of maximum pumping resulted in predicted aquifer drawdowns of one-fourth of the total available drawdown. Flow in a nearby stream was decreased by 40%. Areas of most intensive irrigation in the basin also are areas that have productive aquifers and well-sustained streamflows. Aquifer yield is based on the concept of capture - the volume of increased recharge to the aquifer or decreased discharge from the aquifer that results from pumping. The high rates of capture for aquifers in the basin supply ample water for present (1982) irrigation and for substantial future development. (USGS)

  5. Integrating Strategic and Operational Decision Making Using Data-Driven Dashboards: The Case of St. Joseph Mercy Oakland Hospital.

    PubMed

    Jack Weiner; Balijepally, Venugopal; Tanniru, Mohan

    2015-01-01

    Hospitals have invested and continue to invest heavily in building information systems to support operations at various levels of administration. These systems generate a lot of data but fail to effectively convert these data into actionable information for decision makers. Such ineffectiveness often is attributed to a lack of alignment between strategic planning and information technology (IT) initiatives supporting operational goals. We present a case study that illustrates how the use of digital dashboards at St. Joseph Mercy Oakland (SJMO) Hospital in Pontiac, Michigan, was instrumental in supporting such an alignment. Driven by a focus on key performance indicators (KPIs), dashboard applications also led to other tangible and intangible benefits. An ability to track KPIs over time and against established targets, with drill-down capabilities, allowed leadership to hold staff members accountable for achieving their performance targets. By displaying the dashboards in prominent locations (such as operational unit floors, the physicians' cafeteria, and nursing stations), SJMO ushered in transparency in the planning and monitoring processes. The need to develop KPI metrics and drive data collection efforts became ingrained in the work ethos of people at every level of the organization. Although IT-enabled dashboards have been instrumental in supporting this cultural transformation, the focus of investment was the ability of technology to make collective vision and action the responsibility of all stakeholders.

  6. Integrating Strategic and Operational Decision Making Using Data-Driven Dashboards: The Case of St. Joseph Mercy Oakland Hospital.

    PubMed

    Jack Weiner; Balijepally, Venugopal; Tanniru, Mohan

    2015-01-01

    Hospitals have invested and continue to invest heavily in building information systems to support operations at various levels of administration. These systems generate a lot of data but fail to effectively convert these data into actionable information for decision makers. Such ineffectiveness often is attributed to a lack of alignment between strategic planning and information technology (IT) initiatives supporting operational goals. We present a case study that illustrates how the use of digital dashboards at St. Joseph Mercy Oakland (SJMO) Hospital in Pontiac, Michigan, was instrumental in supporting such an alignment. Driven by a focus on key performance indicators (KPIs), dashboard applications also led to other tangible and intangible benefits. An ability to track KPIs over time and against established targets, with drill-down capabilities, allowed leadership to hold staff members accountable for achieving their performance targets. By displaying the dashboards in prominent locations (such as operational unit floors, the physicians' cafeteria, and nursing stations), SJMO ushered in transparency in the planning and monitoring processes. The need to develop KPI metrics and drive data collection efforts became ingrained in the work ethos of people at every level of the organization. Although IT-enabled dashboards have been instrumental in supporting this cultural transformation, the focus of investment was the ability of technology to make collective vision and action the responsibility of all stakeholders. PMID:26554142

  7. Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease.

    PubMed

    Tan, Chun-Feng; Yamada, Mitsunori; Toyoshima, Yasuko; Yokoseki, Akio; Miki, Yukari; Hoshi, Yasuhiro; Kaneko, Hiroyuki; Ikeuchi, Takeshi; Onodera, Osamu; Kakita, Akiyoshi; Takahashi, Hitoshi

    2009-10-01

    Pathological transactivation-responsive DNA-binding protein 43 (TDP-43) has been identified as a component of ubiquitinated inclusions in frontotemporal lobar degeneration with motor neuron disease, as well as in sporadic and some forms of familial amyotrophic lateral sclerosis. To clarify whether pathological TDP-43 is present in other neurodegenerative diseases involving the motor neuron system, we immunohistochemically examined the brain and spinal cord affected by two CAG repeat (polyglutamine) diseases, Machado-Joseph disease (MJD) and spinal and bulbar muscular atrophy (SBMA), using polyclonal antibody against TDP-43. In all the MJD cases, TDP-43-immunoreactive (ir) neuronal cytoplasmic inclusions (NCIs), although few in number, were found only in the lower motor neurons in the brainstem and spinal cord. TDP-43-ir NCIs appeared as linear wisp-like, skein-like, or thick, somewhat rod-like bodies. These inclusions were also visualized with antibodies against phosphoserines 409 and 410 of TDP-43, and ubiquitin, but were not recognized by antibody against expanded polyglutamine stretches or ataxin-3. The ultrastructure of the TDP-43-ir NCIs was similar to that of the inclusions seen in sporadic ALS, consisting of bundles of parallel filaments. None of the SBMA cases showed abnormal TDP-43 immunoreactivity in any of the regions examined. Immunoblot analysis failed to recognize hyperphosphorylated TDP-43 at ~23 kDa in two MJD cases examined. However, the immunohistochemical findings strongly suggested that in MJD, in addition to the polyglutamine-dependent disease process, TDP-43-related pathogenesis is associated with degeneration and death of the lower motor neurons. PMID:19526244

  8. [Pierre-Joseph Duhem (1758-1807), doctor regicide, and other National Convention physician-deputies vis-a-vis the lawsuit of Louis XVI].

    PubMed

    Dupont, Geneviève; Lellouch, Alain; Olry, Régis

    2006-01-01

    On January 16, 1793, seven hundred aud forty nine deputies of the National Convention are called on to express their opinion by word of mouth about this question: "What penalty Louis, former king of the French, brought upon himself ?" Among these deputies, 47 are or were physicians : 22 vote for death without delay, 3 for suspended death sentence, 20 for indulgence (imprisonment till the peace and banishment thereafter), and 2 refuse to vote. This paper aims at summarizing the attitude of the physicians-deputies, and more specifically those of Pierre-Joseph Duhem, at the time of one of the most famous trials of the history of France.

  9. The cosmic child: The artwork of Joseph Cornell and a type of unusual sensibility, or thinking inside the box: the mind that channels infinity.

    PubMed

    Scheftel, Susan

    2009-01-01

    This paper explores the unique mind of the twentieth- century American artist Joseph Cornell, known for his boxes and collages made with "found" materials. The author interpolates reflections upon Cornell with vignettes from the treatment of a young child, speculating that certain individuals may possess a constellation of vulnerabilities/sensitivities that constitute what is referred to as a "cosmic" sensibility. It is suggested that such an orientation can lead variously to anxieties and separation problems, as well as (or in addition to) intellectual and/or artistic giftedness. The outcome of such dynamics would depend on a complex interplay of temperament, circumstance, and relational attunement.

  10. [Pierre-Joseph Duhem (1758-1807), doctor regicide, and other National Convention physician-deputies vis-a-vis the lawsuit of Louis XVI].

    PubMed

    Dupont, Geneviève; Lellouch, Alain; Olry, Régis

    2006-01-01

    On January 16, 1793, seven hundred aud forty nine deputies of the National Convention are called on to express their opinion by word of mouth about this question: "What penalty Louis, former king of the French, brought upon himself ?" Among these deputies, 47 are or were physicians : 22 vote for death without delay, 3 for suspended death sentence, 20 for indulgence (imprisonment till the peace and banishment thereafter), and 2 refuse to vote. This paper aims at summarizing the attitude of the physicians-deputies, and more specifically those of Pierre-Joseph Duhem, at the time of one of the most famous trials of the history of France. PMID:17152600

  11. Machado-Joseph Disease

    MedlinePlus

    ... for drunkenness, difficulty with speech and swallowing, involuntary eye movements, double vision, and frequent urination. Some individuals also ... color and/or contrast, and inability to control eye movements. Is there any treatment? MJD is incurable, but ...

  12. Machado-Joseph Disease

    MedlinePlus

    ... for drunkenness, difficulty with speech and swallowing, impaired eye movements sometimes accompanied by double vision or bulging eyes, ... color and/or contrast, and inability to control eye movements. Some individuals also experience prominent Parkinson’s disease-like ...

  13. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2002-2003 Annual Report.

    SciTech Connect

    Johnson, R.; McKinstry, C.; Simmons, C.

    2003-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the second year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The 2002 study period extended from May 18 through July 30. The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. The prototype system consisted of six strobe lights affixed to an aluminum frame suspended vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, were aimed to illuminate a specific region directly upstream of the barge. Three light level treatments were used: 6 of 6 lights on, 3 of 6 lights on, and all lights off. These three treatment conditions were applied for an entire 24-hr day and were randomly assigned within a 3-day block throughout the study period. A seven-transducer splitbeam

  14. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2004-2005 Annual Report.

    SciTech Connect

    Johnson, R.; McKinstry, C.; Cook, C.

    2005-02-01

    This report documents a four-year study(a) to assess the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss) at the entrance to the forebay of the third powerplant at Grand Coulee Dam. The work was conducted for the Bonneville Power Administration, U.S. Department of Energy, by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). In this report, emphasis is placed on the methodology and results associated with the fourth project year and compared with findings from the previous years to provide an overall project summary. Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power and Conservation Council Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph dams on the Columbia River (Figure S.1). A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish, including kokanee and rainbow trout, were entrained annually at Grand Coulee Dam. Analysis of the data found that 85% of the total entrainment occurred at the dam's third powerplant. Because these entrainment rates represent a significant loss to the tribal fisheries upstream of the dam, they have been judged unacceptable to fishery managers responsible for perpetuating the fishery in Lake Roosevelt. In an effort to reduce fish entrainment rates, the scope of work for the Chief Joseph Kokanee Enhancement Project was modified in 2001 to include a multiyear study of the efficacy of using strobe lights to deter fish from entering the third powerplant forebay. Pacific Northwest National Laboratory initiated the four-year study in collaboration with Colville Tribal

  15. Chemical composition of root aroma of Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter, an endemic and endangered ethnomedicinal plant from Western Ghats, India.

    PubMed

    Verma, Ram S; Mishra, Priyanka; Kumar, Amit; Chauhan, Amit; Padalia, Rajendra C; Sundaresan, Velusamy

    2014-01-01

    Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter, which belongs to the family Apocynaceae, is a perennial under shrub, endemic to southern Western Ghats, India. The highly aromatic tuberous roots of the D. arayalpathra are used as an effective remedy for peptic ulcer, cancer-like afflictions and as rejuvenating tonic by native tribes. The objective of this study was to characterise the root aroma of D. arayalpathra for possible industrial applications. Hydrodistilled volatile oil of the roots was analysed by gas chromatography-flame ionisation detector and gas chromatography-mass spectrometry. The volatile oil was characterised by the presence of higher amount of an industrially important flavour molecule, 2-hydroxy-4-methoxybenzaldehyde (96.8%) along with some other minor or trace constituents. Owing to characteristic vanillin-like flavour, the root oil of the D. arayalpathra can be explored as a potential substitute of vanillin-aroma in the flavour industry. PMID:24841455

  16. Chemical and biological conditions in Bald Eagle Creek and prognosis of trophic characteristics of Foster Joseph Sayers Reservoir, Centre County, Pennsylvania

    USGS Publications Warehouse

    Flippo, Herbert N.

    1970-01-01

    Foster Joseph Sayers. Reservoir will b.e impounded on moderately fertile soils; however, its water source, Bald Eagle Creek, is a bicarbonate-water stream that is over~y-enriched with nutrients. About 650 of the 1,730 acres to be inundated in summer are subject to infestation with aquatic weeds. Nuisance algal "blooms" are expected to occur in summer. The reservoir will stratify in early summer and water · releas·ed for conservation purposes and acid neutralization will consist mostly of hypolimnetic water. This water will be nearly depleted in. dissolved oxygen and will, at times, contain relatively high concentrations of heavy metallic ions and hydrogen:!sulfide.

  17. The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814–1869) in January 1843

    PubMed Central

    Jansen, T. C.; van der Hoven, B.; Bakker, J.

    2007-01-01

    Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742–1786) in 1780. The German physician–chemist Johann Joseph Scherer (1841–1869) demonstrated the occurrence of lactic acid in human blood under pathological conditions in 1843 and 1851. In this article we honour the forgotten observations by Scherer and describe the influence of Scherer's finding on further research on lactic acid at the end of the 19th century. We conclude that Scherer's 1843 case reports should be cited as the first description of lactic acid in human blood after death and also as the first demonstration of lactic acid as a pathological finding in septic and haemorrhagic shock. Carl Folwarczny was, in 1858, the first to demonstrate lactic acid in blood in a living patient. PMID:17661014

  18. The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina.

    PubMed

    Mooney, Stephen J; Knox, Justin; Morabia, Alfredo

    2014-08-01

    As pellagra reached epidemic proportions in the United States in the early 20th century, 2 teams of investigators assessed its incidence in cotton mill villages in South Carolina. The first, the Thompson-McFadden Commission, concluded that pellagra was likely infectious. The second, a Public Health Service investigation led by Joseph Goldberger, concluded that pellagra was caused by a dietary deficiency. In this paper, we recount the history of the 2 investigations and consider how the differences between the 2 studies' designs, measurements, analyses, and interpretations led to different conclusions. Because the novel dietary assessment strategy was a key feature of the Public Health Service's study design, we incorporated simulated measurement error in a reanalysis of the Public Health Service's data to assess whether this specific difference affected the divergent conclusions.

  19. Chief Joseph Kokanee Enhancement Project : Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grond Coulee Dam Third Powerplant Forebay.

    SciTech Connect

    Simmons, M.A.; McKinstry, C.A.; Simmons, C.S.

    2002-01-01

    Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council's (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC's Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the first year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory (PNNL). The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. Analysis of the effect of strobe lights on the distribution (numbers) and behavior of kokanee and rainbow trout was based on 51, 683 fish targets detected during the study period (June 30 through August 1, 2001). Study findings include the following: (1) Analysis of the count data indicated that significantly more fish were present when the lights were on compared to off. This was true for both the 24-hr tests as well as the 1-hr tests. Powerplant discharge, distance from lights, and date were significant factors in the analysis. (2) Behavioral results indicated that fish within 14 m of the lights were trying to avoid the lights by swimming across the lighted region or

  20. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2003-2004 Annual Report.

    SciTech Connect

    Simmons, M.; McKinstry, C.; Cook, C.

    2004-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish were entrained annually at Grand Coulee Dam. Analysis of the entrainment data found that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the third year of the strobe light study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The objective of the study is to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout under field conditions. The prototype system consists of six strobe lights affixed to an aluminum frame suspended 15 m vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, illuminate a region directly upstream of the barge. The 2003 study period extended from June 16 through August 1. Three light treatments were used: all six lights on for 24 hours, all lights off for 24 hours, and three of six lights cycled on and off every hour for 24 hours. These three treatment conditions were assigned randomly within a

  1. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    PubMed

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  2. Marked phenotypic heterogeneity associated with expansion of a CAG repeat sequence at the spinocerebellar ataxia 3/Machado-Joseph disease locus

    SciTech Connect

    Cancel, G.; Abbas, N.; Stevanin, G.

    1995-10-01

    The spinocerebellar ataxia 3 locus (SCA3) for type I autosomal dominant cerebellar ataxia (ADCA type I), a clinically and genetically heterogeneous group of neurodegenerative disorders, has been mapped to chromosome 14q32.1. ADCA type I patients from families segregating SCA3 share clinical features in common with those with Machado-Joseph disease (MJD), the gene of which maps to the same region. We show here that the disease gene segregating in each of three French ADCA type I kindreds and in a French family with neuropathological findings suggesting the ataxochoreic form of dentatorubropallidoluysian atrophy carries an expanded CAG repeat sequence located at the same locus as that for MJD. Analysis of the mutation in these families shows a strong negative correlation between size of the expanded CAG repeat and age at onset of clinical disease. Instability of the expanded triplet repeat was not found to be affected by sex of the parent transmitting the mutation. Evidence was found for somatic and gonadal mosaicism for alleles carrying expanded trinucleotide repeats. 36 refs., 5 figs., 2 tabs.

  3. Marked Phenotypic Heterogeneity Associated with Expansion of a CAG Repeat Sequence at the Spinocerebellar Ataxia 3/Machado-Joseph Disease Locus

    PubMed Central

    Cancel, Géraldine; Abbas, Nacer; Stevanin, Giovanni; Dürr, Alexandra; Chneiweiss, Hervé; Néri, Christian; Duyckaerts, Charles; Penet, Christiane; Cann, Howard M.; Agid, Yves; Brice, Alexis

    1995-01-01

    The spinocerebellar ataxia 3 locus (SCA3) for type I autosomal dominant cerebellar ataxia (ADCA type I), a clinically and genetically heterogeneous group of neuro-degenerative disorders, has been mapped to chromosome 14q32.1. ADCA type I patients from families segregating SCA3 share clinical features in common with those with Machado-Joseph disease (MJD), the gene of which maps to the same region. We show here that the disease gene segregating in each of three French ADCA type I kindreds and in a French family with neuropatho-logical findings suggesting the ataxochoreic form of dentatorubropallidoluysian atrophy carries an expanded CAG repeat sequence located at the same locus as that for MJD. Analysis of the mutation in these families shows a strong negative correlation between size of the expanded CAG repeat and age at onset of clinical disease. Instability of the expanded triplet repeat was not found to be affected by sex of the parent transmitting the mutation. Evidence was found for somatic and gonadal mosaicism for alleles carrying expanded trinucleotide repeats. ImagesFigure 3Figure 5 PMID:7573040

  4. The (CAG)n tract of Machado–Joseph Disease gene (ATXN3): a comparison between DNA and mRNA in patients and controls

    PubMed Central

    Bettencourt, Conceição; Santos, Cristina; Montiel, Rafael; Kay, Teresa; Vasconcelos, João; Maciel, Patrícia; Lima, Manuela

    2010-01-01

    Machado–Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder of late onset (occurring at a mean age of 40.2 years). The clinical manifestation of MJD is dependent on the presence of an expansion of the (CAG)n motif within exon 10 of the ATXN3 gene, located at 14q32.1. The variance in onset of MJD is only partially correlated (∼50–80%) with the extension of the CAG tract in genomic DNA (gDNA). The main aim of this work was to determine whether there are discrepancies in the size of the (CAG)n tract between gDNA and mRNA, and to establish whether there is a better association between age at onset and repeat size at the mRNA level. We typed gDNA and cDNA samples for the (CAG)n tract totalizing 108 wild-type and 52 expanded ATXN3 alleles. In wild-type alleles no differences were found between gDNA and cDNA. In expanded alleles, the CAG repeat size in gDNA was not always directly transcribed into the mRNA; on average there were differences of +1 repeat at the cDNA level. The slight discrepancies obtained were insufficient to cause significant differences in the distribution of the expanded alleles, and therefore no improvement in onset variance explanation was obtained with mRNA. PMID:19935829

  5. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    PubMed

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance. PMID:27364256

  6. Treating Palliative Care Patients with Pain with the Body Tambura: A Prospective Case Study at St. Joseph's Hospice for Dying destitute in Dindigul South India

    PubMed Central

    Dietrich, Cordula; Teut, M; Samwel, Kakuko Lopoyetum; Narayanasamy, S; Rathapillil, T; Thathews, G

    2015-01-01

    Background: The Body Tambura is a recently invented stringed instrument that is used for receptive music therapy designed to be placed and attached on the human body. The aim of this study was to record perceived effects of a treatment with the Body Tambura on palliative care patients with special reference to pain. Materials and Methods: A prospective case study was carried out with patients of St. Joseph's Hospice for Dying Destitute in Dindigul/South India. Patients were treated with a treatment after baseline assessment and also on the next day. Outcomes were measured quantitatively by using a numeric rating scale (0–10, 10 maximum intensity of pain felt) at baseline, directly after treatment, and the day after the treatment to determine the intensity of the pain. Results: Ten patients (five women and five men) participated in the study. The majority described the therapy as a pleasant experience. The pain intensity at baseline was reduced from 8.3 ± standard deviation (SD) 1.16 to 4.6 ± 1.52 at day 1 and from 4.6 ± 2.07 to 2.4 ± 1.58 at day 2. Conclusion: A clinically relevant pain reduction was described as short time outcome; the therapy was received and perceived well. Forthcoming research should include a control group, randomization, a larger number of participants, and a longer period of treatment. PMID:26009680

  7. Spinocerebellar ataxia type 1 and Machado-Joseph disease: Incidence of CAG expansions among adult-onset ataxia patients from 311 families with dominant, recessive, or sporadic ataxia

    SciTech Connect

    Ranum, L.P.W.; Gomez, C.; Orr, H.T.

    1995-09-01

    The ataxias are a complex group of diseases with both environmental and genetic causes. Among the autosomal dominant forms of ataxia the genes for two, spinocerebellar ataxia type 1 (SCA1) and Machado-Joseph disease (MJD), have been isolated. In both of these disorders the molecular basis of disease is the expansion of an unstable CAG trinucleotide repeat. To assess the frequency of the SCA1 and MJD trinucleotide repeat expansions among individuals diagnosed with ataxia, we have collected DNA from individuals representing 311 families with adult-onset ataxia of unknown etiology and screened these samples for trinucleotide repeat expansions within the SCA1 and MJD genes. Within this group there are 149 families with dominantly inherited ataxia. Of these, 3% have SCA1 trinucleotide repeat expansions, whereas 21% were positive for the MJD trinucleotide expansion. Thus, together SCA1 and MJD represent 24% of the autosomal dominant ataxias in our group, and the frequency of MJD is substantially greater than that of SCA1. For the 57 patients with MJD trinucleotide repeat expansions, a strong inverse correlation between CAG repeat size and age at onset was observed (r = -.838). Among the MJD patients, the normal and affected ranges of CAG repeat size are 14-40 and 68-82 repeats, respectively. For SCA1 the normal and affected ranges are much closer, containing 19-38 and 40-81 CAG repeats, respectively. 30 refs., 1 fig., 3 tabs.

  8. Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.

    PubMed

    Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P

    2016-01-28

    A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed. PMID:26601773

  9. Application of the FluEgg model to predict transport of Asian carp eggs in the Saint Joseph River (Great Lakes tributary)

    USGS Publications Warehouse

    Garcia, Tatiana; Murphy, Elizabeth A.; Jackson, P. Ryan; Garcia, Marcelo H.

    2015-01-01

    The Fluvial Egg Drift Simulator (FluEgg) is a three-dimensional Lagrangian model that simulates the movement and development of Asian carp eggs until hatching based on the physical characteristics of the flow field and the physical and biological characteristics of the eggs. This tool provides information concerning egg development and spawning habitat suitability including: egg plume location, egg vertical and travel time distribution, and egg-hatching risk. A case study of the simulation of Asian carp eggs in the Lower Saint Joseph River, a tributary of Lake Michigan, is presented. The river hydrodynamic input for FluEgg was generated in two ways — using hydroacoustic data and using HEC-RAS model data. The HEC-RAS model hydrodynamic input data were used to simulate 52 scenarios covering a broad range of flows and water temperatures with the eggs at risk of hatching ranging from 0 to 93% depending on river conditions. FluEgg simulations depict the highest percentage of eggs at risk of hatching occurs at the lowest discharge and at peak water temperatures. Analysis of these scenarios illustrates how the interactive relation among river length, hydrodynamics, and water temperature influence egg transport and hatching risk. An improved version of FluEgg, which more realistically simulates dispersion and egg development, is presented. Also presented is a graphical user interface that facilitates the use of FluEgg and provides a set of post-processing analysis tools to support management decision-making regarding the prevention and control of Asian carp reproduction in rivers with or without Asian carp populations.

  10. Psychological Well-Being and Family Satisfaction Levels Five Years After Being Confirmed as a Carrier of the Machado-Joseph Disease Mutation

    PubMed Central

    Gonzalez, Carlos; Gomes, Elisabete; Kazachkova, Nadiya; Bettencourt, Conceição; Raposo, Mafalda; Kay, Teresa Taylor; MacLeod, Patrick; Vasconcelos, João

    2012-01-01

    The present study on long-term outcome of presymptomatic testing for Machado-Joseph disease (MJD) aimed to evaluate the psychological well-being and the familial satisfaction of subjects that 5 years prior received an unfavorable result in the predictive testing (PT). The study included 47 testees of Azorean origin (23 from the island of Flores and 24 from S. Miguel) that completed the fourth evaluation session of the MJD protocol, and undertook a neurological examination at the moment of participation in the study. Nearly 50% of testees were symptomatic at the time of the study. Psychological well-being of the 47 participants was evaluated using the Psychological General Well-Being Index (PGWB). The family satisfaction scale by adjectives was applied to obtain information on family dynamics. The average PGWB score of the total participants was of 73.3, a value indicative of psychological well-being. Nearly half of the testees presented scores indicating psychological well-being, whereas scores indicating moderate (28.9%) or severe (23.7%) stress were found in the remaining. The average score in the PGWB scale was lower in symptomatic than in asymptomatic subjects; moreover, the distinct distribution of the well-being categories seen in the two groups shows an impact of the appearance of first symptoms on the psychological state. Motives for undertaking the test, provided 5 years prior, failed to show an impact in well-being. The average score for familial satisfaction was of 134, a value compatible with high familial satisfaction, which represented the most frequent category (59.6%). Results demonstrate that well-being and family satisfaction need to be monitored in confirmed carriers of the MJD mutation. The inclusion of acceptance studies, after PT, as well as the development of acceptance training actions, should be of major importance to anticipate the possibility of psychological damage. PMID:23153003

  11. Non-Mendelian transmission in dentatorubral-pallidolysian atrophy and Machado-Joseph disease: The mutant allele is preferentially transmitted in male meiosis

    SciTech Connect

    Ikeuchi, Takeshi; Igarashi, Shuichi; Takiyama, Yoshihisa; Onodera, Osamu

    1996-04-01

    Autosomal dominant dentatorubral-pallidoluysian atrophy (DRPLA) and Machado-Joseph disease (MJD) are neurodegenerative disorders caused by CAG trinucleotide repeat expansions. An inverse correlation of age at onset with the length of the expanded CAG trinucleotide repeats has been demonstrated, and the intergenerational instability of the length of the CAG trinucleotide repeats, which is more prominent in paternal than in maternal transmissions, has been shown to underlie the basic mechanisms of anticipation in DRPLA and MJD. Our previous observations on DRPLA and MJD pedigrees, as well as a review of the literature, have suggested that the numbers of affected offspring exceed those of unaffected offspring, which is difficult to explain by the Mendelian principle of random segregation of alleles. In the present study, we analyzed the segregation patterns in 211 transmissions in 24 DRPLA pedigrees and 80 transmissions in 7 MJD pedigrees, with the diagnoses confirmed by molecular testing. Significant distortions in favor of transmission of the mutant alleles were found in male meiosis, where the mutant alleles were transmitted to 62% of all offspring in DRPLA ({chi}{sup 2} = 7.69; P < .01) and 73% in MJD ({chi}{sup 2} = 6.82; P < .01). The results were consistent with meiotic drive in DRPLA and MJD. Since more prominent meiotic instability of the length of the CAG trinucleotide repeats is observed in male meiosis than in female meiosis and meiotic drive is observed only in male meiosis, these results raise the possibility that a common molecular mechanism underlies the meiotic drive and the meiotic instability in male meiosis. 23 refs., 1 tab.

  12. Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.

    PubMed

    Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P

    2016-01-28

    A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed.

  13. Late-Quaternary morphostratigraphy of Lake St-Joseph (southeastern Canadian Shield): Evolution from a semi-enclosed glacimarine basin to a postglacial lake

    NASA Astrophysics Data System (ADS)

    Normandeau, Alexandre; Lajeunesse, Patrick; Philibert, Geneviève

    2013-09-01

    This paper reports and describes multibeam echosounder, subbottom profiler and sediment sampling data collected in Lake St-Joseph (southern Québec), a formerly glacimarine sedimentary basin that has been glacio-isostatically uplifted to form a small lake. Its study provides a unique opportunity for investigating changes in sedimentary environments from a glacial sea to a postglacial lake. Multibeam bathymetry allows the observation of two basins separated by a bathymetric ridge and of mass movement deposits in both basins. High resolution seismic stratigraphy reveals the presence of seven seismic units. These seven units relate to the advance and retreat of the Laurentide ice-sheet over the region. Following ice-retreat, transparent (U3) and high amplitude reflection (U4) units were deposited during the Champlain Sea invasion. The transparent unit likely represents a rapidly retreating glacier, which allowed the deposition of massive silt and clay, whereas the high amplitude reflectors, which are internally composed of transparent to chaotic lenses, are interpreted as the result of a deceleration of ice-retreat or a stabilization of the glacier and of glacio-isostatic rebound. Overlying the Champlain Sea sediments, a unit composed of smaller laminations (U5) suggests that it was deposited during the marine to lacustrine transition, in a paraglacial environment. This is supported by its presence in the northern basin, where the Rivière-aux-Pins mouth is located and its absence in the southern basin, where no river is observed. The bathymetric ridge between the two basins thus limited sediment transport. Following the complete retreat of the Champlain Sea, organic-rich sediments (U7) were deposited in the lake. In the northern basin, the presence of the Rivière-aux-Pins allowed their deposition in the form of rhythmites whereas the absence of rivers in the southern basin resulted in the deposition of an acoustically transparent unit. A mass movement (U6

  14. Larmor, Joseph (1857-1942)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Physicist, born in Magheragall, County Antrim, Ireland, became Lucasian professor in Cambridge, working on electricity, dynamics and thermodynamics, and especially the ether, the postulated material which pervades space and in which electromagnetic radiation travels. Finding no evidence that the ether existed, he was led to some of the results inherent in EINSTEIN's theory of relativity, giving a...

  15. An Interview with Joseph Jastrab.

    ERIC Educational Resources Information Center

    Schneider, Bruce

    1998-01-01

    An interview with a counselor who leads wilderness vision-quests discusses risk-taking as an element of adolescent development, the development of a fear of death, recognition of the universal nature of that fear, the lack of rites of passage in modern society, and the ways in which wilderness experiences can foster self-discovery and spiritual…

  16. Cultivating Fertile Grounds: Enhancing and Extending the Scientific Base of Social and Emotional Learning--A Commentary on "The Scientific Base Linking Social and Emotional Learning to School Success," a Chapter by Joseph E. Zins, Michelle R. Bloodworth, Roger P. Weissberg, and Herbert J. Walberg

    ERIC Educational Resources Information Center

    Manz, Patricia H.

    2007-01-01

    Joseph Zins was a forerunner in empirically demonstrating the interrelationship of SEL interventions and school success. This commentary highlights his perspectives on the accumulating body of evidence for the academic gains that have been associated with various SEL interventions and aims to show how new research methodologies can further extend…

  17. Talking the Higgs Boson with Dr. Joseph Incandela: Third Lecture in the DOE Science Speaker Series (includes opening remarks from Dr. Bill Brinkman and introduction by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Incandela, Joseph

    2012-09-14

    In July of 2012, scientists leading two different research teams, working independently of each other, announced that they had almost certain proof of the long-sought Higgs boson. Though Cern did not call the discovery "official", many physicists conceded the evidence was now so compelling they had surely found the missing particle. The formal confirmation will come over the next few months of further investigation. The experiments are taking place at the Large Hadron Collider (LHC), and this third lecture in the DOE Science Speaker Series is given by one of those announcing scientists in July. He is Dr. Joseph Incandela, the current spokesperson for the Compact Muon Solenoid (CMS) Experiment at CERN. He was heavily involved in the search for the top quark at Fermi and is from the University of California, Santa Barbara. The title he gives his presentation is "Searching for the genetic code of our universe: Discovery at the LHC."

  18. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grand Coulee Dam Third Powerplant Forebay, 2005-2006 Annual Report.

    SciTech Connect

    Simmons, M.; Johnson, Robert; McKinstry, C.

    2006-03-01

    The construction of Grand Coulee and Chief Joseph dams on the Columbia River resulted in the complete extirpation of the anadromous fishery upstream of these structures. Today, this area is totally dependent upon resident fish resources to support local fisheries. The resident fishing is enhanced by an extensive stocking program for target species in the existing fishery, including kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss). The kokanee fishery in Lake Roosevelt has not been meeting the return goals set by fisheries managers despite the stocking program. Investigations of physical and biological factors that could affect the kokanee population found predation and entrainment had a significant impact on the fish population. In 1999 and 2000, walleye (Sander vitreum) consumed between 15% and 9%, respectively, of the hatchery kokanee within 41 days of their release, while results from a study in the late 1990s estimated that entrainment at Grand Coulee Dam could account for up to 30% of the total mortality of the stocked fish. To address the entrainment loss, the Bonneville Power Administration commissioned a study to determine if fish would avoid areas illuminated by strobe lights in the forebay of the third powerplant. This work was conducted by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). From 2002 through 2004, six strobe lights were suspended in the center of the opening to the third powerplant forebay during summer months. Results from those studies indicated that fish appeared to be attracted to the illuminated area but only at night and when flow conditions within the third powerplant forebay were minimal. However, small but consistent results from these studies indicated that under high flow conditions, fish might be avoiding the lights. The 2005 study was designed to examine whether, under high flow conditions near the penstock

  19. Using 3D Acoustic Telemetry to Assess the Response of Resident Salmonids to Strobe Lights in Lake Roosevelt, Washington; Chief Joseph Kokanee Enhancement Feasibility Study, Annual Report 2001-2002.

    SciTech Connect

    Perry, Russlee; Farley, M.; Hansen, Gabriel

    2003-01-01

    In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse. In response to finding high entrainment at Grand Coulee Dam, the Independent Scientific Review Panel (ISRP) recommended investigating the use of strobe lights to repel fish from the forebay of the third powerhouse. Therefore, our study focused on the third powerhouse and how strobe lights affected fish behavior in this area. The primary objective of our study was to assess the behavioral response of kokanee and rainbow trout to strobe lights using 3D acoustic telemetry, which yields explicit spatial locations of fish in three dimensions. Our secondary objectives were to (1) use a 3D acoustic system to mobile track tagged fish in the forebay and upriver of Grand Coulee Dam and (2) determine the feasibility of detecting fish using a hydrophone mounted in the tailrace of the third powerhouse. Within the fixed hydrophone array located in the third powerhouse cul-de-sac, we detected 50 kokanee and 30 rainbow trout, accounting for 47% and 45% respectively, of the fish released. Kokanee had a median residence time of 0.20 h and rainbow trout had a median residence time of 1.07 h. We detected more kokanee in the array at night compared to the day, and we detected more rainbow trout during the day compared to the night. In general, kokanee and rainbow trout approached along the eastern shore and the relative frequency of kokanee and rainbow trout detections was highest along the eastern shoreline of the 3D array. However, because we

  20. [Paskal Joseph Ritter von Ferro, the Reformer of the Austrian Public Health. On the occasion of the 200th anniversary of his death in consequence of the battle of Wagram against Napoleon].

    PubMed

    Flamm, Heinz

    2009-01-01

    Paskal Joseph Ferro, born on June 5th, 1753 in Bonn, Germany, in the course of his military service as a surgeon graduated medicine in 1777 in Strasbourg and Vienna. Here initially he worked as a private physician in a hospital. In 1785 he became an assistant to the leading municipal physician, in 1793 he was appointed director of the district hospitals and in 1793 medical official in charge of Lower Austria. In 1795 Ferro was the first on the now created position of "Protomedicus" (director of the health administration) of an Austrian country. His most important acts were the creation of the first medical cold water bath in Austria, the foundation of institutions for the salvation of casualties, the introduction of rooms to lay out the dead in the communities, the organization of dispersed health regulations and their publications for common knowledge and especially the introduction of the smallpox vaccination in 1799 first time outside the UK. After the battle of Wagram (north to Vienna) in the Napoleonic war (July 6th, 1809) he had to care for the wounded and 56,000 dead soldiers on the battle field. In this action he contracted typhoid fever and consequently died on August 21st, 1809.

  1. Linkage disequilibrium at the Machado-Joseph disease spinal cerebellar ataxia 3 locus: Evidence for a common founder effect in French and Portuguese-Brazilian families as well as a second ancestral Portuguese-Azorean mutation

    SciTech Connect

    Stevanin, G.; Cancel, G.; Didierjean, O.

    1995-11-01

    Spinal cerebellar ataxia 3 (SCA3) is a genetic subtype of the type I autosomal dominant cerebellar ataxias (ADCA type I), a clinically and genetically heterogeneous group of neurological disorders. SCA3 was mapped in French families to chromosome 14q24.3-qter in the same region as the gene for Machado-Joseph disease (MJD), which was classified as a form of ADCA type I on the basis of similarities in the clinical presentation of individual patients. The MJD gene was recently identified in Japanese kindreds, and the mutation was characterized as an unstable CAG repeat that is expanded in affected individuals. The same mutation is observed in families of Portuguese-Azorean ancestry, as well as in French SCA3 kindreds. In other disorders caused by unstable and expanded triplet repeats, such as fragile X syndrome (FRA-X), myotonic dystrophy (MD), Huntington disease (HD), and SCA1, linkage disequilibrium (LD) between the mutation and closely linked polymorphic markers was detected, suggesting that there were only one or a few founders or predisposing haplotypes. In the present study, 29 families of different geographical origins were tested for LD between the MJD/SCA3 mutation and four flanking microsatellite markers. 27 refs., 2 tabs.

  2. OMICS and 21st century brain surgery from education to practice: James Rutka of the University of Toronto interviewed by Joseph B. Martin (Boston) and Türker Kılıç (İstanbul).

    PubMed

    Rutka, James; Martin, Joseph; Kılıç, Türker

    2014-12-01

    The Science-in-Backstage interviews aim to share experiences by global medical and life sciences thought leaders on emergent technologies and novel scientific, medical, and educational practices, situating them in both a historical and contemporary science context so as to "look into the biotechnology and innovation futures" reflexively and intelligently. OMICS systems diagnostics and personalized medicine are greatly impacting brain surgery, not to forget the training of the next generation of neurosurgeons. What do the futures hold for the practice of, and education in 21(st) century brain surgery in the age of OMICS systems science, personalized medicine, and the use of simulation in surgeon training? James Rutka is a clinician scientist and a world leader in diagnosis and treatment of brain tumors. He is Professor and Chair of the Department of Surgery at the Faculty of Medicine, University of Toronto, a President Emeritus of the American Association of Neurological Surgeons, and Editor-in-Chief of the Journal of Neurosurgery. Professor Rutka was interviewed for the global medical, biotechnology, and life sciences readership of the OMICS: A Journal of Integrative Biology to speak on these pressing questions in his personal capacity as an independent senior scholar. The issues debated in the present interview are of broad relevance for 21(st) century surgery and postgenomics medicine. The interviewers were Professor Joseph B. Martin, Harvard Medical School Dean Emeritus in Boston and Joint Dean of Medicine at Bahçeşehir University in İstanbul, and the author of "Alfalfa to Ivy: Memoir of a Harvard Medical School Dean," and Professor Türker Kılıç, Dean of Medicine at Bahçeşehir University in İstanbul, and an elected member of the Turkish Academy of Sciences. PMID:25401980

  3. Intergenerational instability of the CAG repeat of the gene for Machado-Joseph disease (MJD1) is affected by the genotype of the normal chromosome: implications for the molecular mechanisms of the instability of the CAG repeat.

    PubMed

    Igarashi, S; Takiyama, Y; Cancel, G; Rogaeva, E A; Sasaki, H; Wakisaka, A; Zhou, Y X; Takano, H; Endo, K; Sanpei, K; Oyake, M; Tanaka, H; Stevanin, G; Abbas, N; Dürr, A; Rogaev, E I; Sherrington, R; Tsuda, T; Ikeda, M; Cassa, E; Nishizawa, M; Benomar, A; Julien, J; Weissenbach, J; Wang, G X; Agid, Y; St George-Hyslop, P H; Brice, A; Tsuji, S

    1996-07-01

    Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by unstable expansion of a CAG repeat in the MJD1 gene at 14q32.1. To identify elements affecting the intergenerational instability of the CAG repeat, we investigated whether the CGG/GGG polymorphism at the 3' end of the CAG repeat affects intergenerational instability of the CAG repeat. The [expanded (CAG)n-CGG]/[normal (CAG)n-GGG] haplotypes were found to result in significantly greater instability of the CAG repeat compared to the [expanded (CAG)n-CGG]/[normal (CAG)n-CGG] or [expanded (CAG)nGGG]/[normal (CAG)n-GGG] haplotypes. Multiple stepwise logistic regression analysis revealed that the relative risk for a large intergenerational change in the number of CAG repeat units (< -2 or > 2) is 7.7-fold (95% CI: 2.5-23.9) higher in the case of paternal transmission than in that of maternal transmission and 7.4-fold (95% CI: 2.4-23.3) higher in the case of transmission from a parent with the [expanded (CAG)n-CGG]/[normal (CAG)n-GGG] haplotypes than in that of transmission from a parent with the [expanded (CAG)n-CGG]/[normal (CAG)n-CGG] or [expanded (CAG)n-GGG]/[normal (CAG)n-GGG] haplotypes. The combination of paternal transmission and the [expanded (CAG)n-CGG]/[normal (CAG)n-GGG] haplotypes resulted in a 75.2-fold (95% CI: 9.0-625.0) increase in the relative risk compared with that of maternal transmission and the [expanded (CAG)n-CGG]/[normal (CAG)n-CGG] or [expanded (CAG)n-GGG]/[normal (CAG)n-GGG] haplotypes. The results suggest that an inter-allelic interaction is involved in the intergenerational instability of the expanded CAG repeat. PMID:8817326

  4. Delisle, Joseph-Nicolas (fl. eighteenth century)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    French astronomer, member of the Académie, hired CHARLES MESSIER as a draftsman, and as a recorder of astronomical observations. Visited ISAAC NEWTON in London in 1724. Calculated the return path for HALLEY's Comet in 1758-9 and published a map which guided the recovery search, showing the predicted path of return calculated at 10 day intervals. Messier, as his observing assistant, was set to obs...

  5. An Interview with Sir Keith Joseph.

    ERIC Educational Resources Information Center

    Special Education: Forward Trends, 1983

    1983-01-01

    The interview with Britain's Secretary of State for Education focuses on special education policies, includng such topics as the role of microelectronics, parent participation, services for integrated students, and curriculum development for children with moderate learning difficultties. (CL)

  6. Joseph Tofte Bruns: Wrestling with Big Ideas

    ERIC Educational Resources Information Center

    Cosier, Kimberly

    2010-01-01

    Joe Bruns is currently a student in the Post-Baccalaureate Teacher Certification Program at the University of Wisconsin-Milwaukee. The series of work featured in this interview centers on the idea of relationships. Joe explores collective and implicated relationship to the work of Felix Gonzalez-Torres through the reuse of paper taken from…

  7. Joseph Henry and the American Philosophical Society

    ERIC Educational Resources Information Center

    Gross, Walter E.

    1972-01-01

    A study of the extent to which Henry was affiliated with the Society and its influence on his work including his evolving relationship with the Society in the scope of the changing nature of American scientific institutions. (DF)

  8. Inflammation, suppuration, putrefaction, fermentation: Joseph Lister's microbiology

    PubMed Central

    Richardson, Ruth

    2013-01-01

    This paper focuses on Lister's inaugural lecture at King's College, London, in October 1877. As the new Professor of Clinical Surgery, Lister had much to report, including impressively high survival rates from complex operations previously regarded as foolhardy. Instead, he chose to address the processes of fermentation in wine, blood and milk. His reasons are not obvious to a modern audience, just as they probably were not to those who heard him in the Great Hall at King's. Having brought microbiological apparatus from his laboratory to the lecture theatre and presented proof of bacterial variety and specificity, Lister publicly demonstrated the creation of the first pure bacterial culture in the history of microbiology. It was an ingenious and well-thought-out strategy designed to generate a frame of mind among his new colleagues and future students, receptive to the causative role of bacteria in septic diseases. His timing was impeccable.

  9. Mapping of the gene for Machado-Joseph disease within a 3.6-cM interval flanked by D14S291/D14S280 and D14S81, on the basis of studies of linkage and linkage disequilibrium in 24 Japanese families

    SciTech Connect

    Sasaki, Hidenao; Ihara, Tatsuo; Wakisaka, Akemi; Takada, Akio; Yoshiki, Takashi; Hamada, Takeshi; Suzuki, Yoshihiro; Iwabuchi, Kiyoshi; Onari, Keiko; Tada, Jyoji

    1995-01-01

    The gene locus of Machado-Joseph disease (MJD) has recently been mapped within a 29-cM subregion of 14q chromosome. We did a linkage study of 24 multigenerational MJD Japanese pedigrees, in an attempt to narrow the candidate region of this gene. Pairwise and multipoint linkage analysis, together with haplotype segregation analysis, led to the conclusion that the MJD gene is located at the 6.8-cM interval between D14S256 and D14S81 (Z{sub max} = 24.78, multipoint linkage analysis). D14S291 and D14S280, located at the center of this interval, showed no obligate recombination with the MJD gene (Z{sub max} = 5.93 for D14S291 and 9.99 for D14S280). A weak, but significant, linkage disequilibrium of MJD gene was noted with D14S81 (P<.05) but not with D14S291 or D14S280. These results suggest that a 3.6-cM interval flanked by D14S291/D14S280 and D14S81 is the most likely location of the MJD gene and that it is closest to D14S81. 33 refs., 4 figs., 6 tabs.

  10. Joseph Godwin Greenfield: The father of neuropathology (1884-1958)

    PubMed Central

    Bhattacharyya, Kalyan B.; Rai, Saurabh

    2015-01-01

    The systematic study of neuropathology was initiated by Godwin Greenfield in the early part of the 20th century. He worked at the National Hospital, Queen Square, London for the major period of his life and worked on various subjects like cerebrospinal fluid, intracranial tumours, cerebellar ataxias, dystrophia myotonica, disseminated sclerosis, subacute combined degeneration of the spinal cord, and the like. After his retirement he visited the National Institute of Neurological Diseases and Blindness in Bethesda, Maryland, USA, from time to time and there he died suddenly from myocardial infarction. PMID:26425005

  11. Ground-water quality in northeastern St. Joseph County, Indiana

    USGS Publications Warehouse

    Fenelon, J.M.; Bayless, E. Randall; Watson, Lee R.

    1995-01-01

    No industrial organic compounds were detected in the water samples. Four pesticides - alachlor, carbofuran, metolachlor, and triazines - were detected in water samples; the highest pesticide concentration in a water sample was 1.0 microgram per liter of alachlor.

  12. More than a Metaphor: The Education of Joseph Knecht

    ERIC Educational Resources Information Center

    Roberts, Peter

    2008-01-01

    Education is a key theme in Hermann Hesse's final novel, "The Glass Bead Game". The book begins with a narrator's introduction, in which the Glass Bead Game is described as a way of playing with the total contents of culture--of drawing connections between disciplines, knowledge and values. The main part of the novel is devoted to the life of…

  13. The Life and Work of Joseph Fraunhofer (1787-1826)

    ERIC Educational Resources Information Center

    Leitner, Alfred

    1975-01-01

    Describes Fraunhofer's scientific career as a glass and lens maker, a discoverer of dark lines in the solar spectrum, a corrector of lens aberration, and investigator of diffraction. Gives biographical data and anecdotes. Includes a bibliography, mainly of German sources. (GH)

  14. 33 CFR 117.651 - St. Joseph River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from three minutes before to three minutes after the hour and half hour, and the draw of the Bicentennial bridge need be opened only from three minutes before to three minutes after the quarter and...

  15. [Was Louis-Joseph Proust (1754-1826) a pharmacist?].

    PubMed

    Fournier, J

    1999-01-01

    Proust's first formulation of the law of definite proportions was published in a paper on iron oxides (1794). He spent the major part of his professional life in Spain, where he contracted to take a teaching and searching position. He was apprenticed to his father to study pharmacy, and he studied chemistry with Hilaire-Marin Rouelle. His early interrupted education is shown through his abilities as an analyst, the persons with whom he was in communication, his share in manufacturers' assays and his researches towards health and food chemistry. More fundamental was his belief in natural principles of order as representative of the thought of the ideologues.

  16. Shapes and Spaces: Inside Joseph Lancaster's Monitorial "Laboratory."

    ERIC Educational Resources Information Center

    Newman, Neville F.

    1998-01-01

    Examines the nature of discipline in the monitorial school by referencing Lancaster's original school model. Illustrates how classroom design can impact discipline. Explores two of Lancaster's topics, looking at influences the British monitorial school had on its North American counterpart. (AS)

  17. A King over Egypt, Which Knew Not Joseph.

    ERIC Educational Resources Information Center

    Coffman, William E.

    1993-01-01

    Although it is true that today's education needs improvement, schools today are not all bad. The opinions of the following five experts, whose views are worth hearing are introduced: (1) Thomas Hopkins; (2) Ralph Tyler; (3) E. F. Lindquist; (4) Walter Cook; and (5) Harold Benjamin. (SLD)

  18. Joseph F. Keithley Award: Force microscopy with subatomic spatial resolution

    NASA Astrophysics Data System (ADS)

    Giessibl, Franz

    2014-03-01

    For a long time, atomic force microscopy has been inferior to the scanning tunneling microscope (STM) in its spatial resolution, partially because measurements of small forces are more challenging than measurements of small currents. With the introduction of frequency modulation force microscopy, the static deflection measurement of a cantilever under a tip-sample force was replaced by a frequency measurement of an oscillating cantilever induced by an average force gradient. Atomic resolution of the challenging silicon reconstruction by frequency modulation atomic force microscopy has been demonstrated in 1995 using a silicon cantilever with a stiffness of k = 17 N/m and an oscillation amplitude of A = 34 nm. In 1996, a quartz cantilever (``qPlus sensor''), originally built from a quartz tuning fork from a wristwatch, has been proposed. At k = 1800 N/m, this quartz sensor is 100 times stiffer than the original Si cantilever, allowing stable oscillation amplitudes down to fractions of an atomic diameter. It has a high Q factor, simple piezoelectric readout, little frequency variation with temperature and allows to simply mount metal tips as used in STM. The demonstration of high spatial resolution, the detection of very small forces, the capability to perform simultaneous STM and AFM as well as the ease of use of the qPlus sensor has led to its adaptation in leading scanning probe microscopy laboratories worldwide as well as in a growing number of commercial scanning probe instruments.

  19. The alleged poisoning of Joseph Stalin: proof beyond reasonable doubt?

    PubMed

    Quigley, James; Keating, Áine

    2013-12-01

    The name "Ioseb Besarionis dze Dzhugashvili" is as unassuming as it is unknown. It is the birth name of the brutal dictator who changed the face of Europe and whose actions still influence our lives today. Stalin, the man responsible for the slaughter of over twenty million of his own Soviet citizens and yet, the man who transformed the USSR from the feudalistic society of the Tsar's to a twentieth century military powerhouse that was instrumental in the defeat of Nazi Germany. Known as "Koba" to his friends, he cultivated a cult of personality where he was, and to a certain extent still is, admired in Russia and the former Soviet states. This paper will look at the following questions: why when he fell gravely ill did his comrades wait so long before seeking medical assistance? why were there omissions in the final post mortem report?, and why did one his closest lieutenants boast so openly about having murdered him.

  20. Joseph A. Burton Forum Award: Some Nuclear Weapons Dilemmas

    NASA Astrophysics Data System (ADS)

    May, Michael

    2014-03-01

    Nuclear weapons pose a combination of political and ethical dilemmas the solution to which has not been found. On one hand, in the view of both US government leaders and US allies, nuclear deterrence continues to play an essential part in the US role as the ultimate source of military strength for the alliances among the major democratic countries. It also continues to be in demand by countries that believe themselves to be isolated and threatened. On the other hand, nuclear weapons, besides being effective deterrents, can cause unprecedented loss of life and risk the demise of civilizations. No ban or technical precaution could prevent the rebuilding of nuclear weapons in a crisis. No diplomatic arrangement to date has erased the threat of invasion and war in the world. Only the abandonment of war and the threat of war as instruments of policy can make nuclear weapons obsolete. The slow, halting, risky road to that end remains the only hope for a world in which lasting solutions to the nuclear dilemmas are possible.

  1. Joseph eleve des poissons au Gabon. Guide pour l'elevage des poissons (Joseph Raises Fish in Gabon. Guide for Raising Fish).

    ERIC Educational Resources Information Center

    Needham, Scott

    A guide, in French, to raising fish for food and profit is designed to instruct and encourage Gabonese natives to establish family fisheries. It describes and illustrates in story form the process used to plan the fishery, clear the land, seek help from an agricultural agent, create a dam, make compost, plan and build the pond, feed the fish,…

  2. Development of the EURITRACK tagged neutron inspection system

    NASA Astrophysics Data System (ADS)

    Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Mercier, E.; Sannie, G.; Viesti, G.; Nebbia, G.; Pesente, S.; Lunardon, M.; Moretto, S.; Fabris, D.; Zenoni, A.; Bonomi, G.; Donzella, A.; Fontana, A.; Boghen, G.; Valkovic, V.; Sudac, D.; Moszynski, M.; Batsch, T.; Gierlik, M.; Woski, D.; Klamra, W.; Isaksson, P.; Le Tourneur, P.; Lhuissier, M.; Colonna, A.; Tintori, C.; Peerani, P.; Sequeira, V.; Salvato, M.

    2007-08-01

    The EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project is part of the 6th European Union Framework Program. It aims at developing a Tagged Neutron Inspection System (TNIS) to detect illicit materials, such as explosives and narcotics, in cargo containers. Fast neutron induced reactions produce specific gamma-rays used to determine the chemical composition of the inspected material. The associated particle technique is employed to precisely locate the interaction points of the neutrons. A new deuterium-tritium neutron generator has been developed, including a pixelized alpha particle detector. The TNIS also comprises high-efficiency fast neutron and gamma-ray detectors, a dedicated front-end electronics and an integrated software to entirely drive the system and automatically process the data. Most components have been integrated during last months at Institute Ruder Boskovic, in Zagreb, Croatia. An overview of the TNIS and of its preliminary performances is presented.

  3. 76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... does business. See Scott Sandarg, DMD, 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA... hearing, at which he may ultimately prevail. See, e.g., Bourne Pharmacy, 72 FR 18,273, 18,274 (2007); Agostino Carlucci, M.D., 49 FR 33,184, 33,184-85 (1984). Rather, what matters--as DEA has repeatedly...

  4. The Honors Program in English at Central High School, St. Joseph, Missouri.

    ERIC Educational Resources Information Center

    Frazier, Virginia F.

    High school honors programs can help meet the needs of students who have an extra measure of intellectual ability and the desire to learn in depth, become independent, and pursue special interests. This paper points out how little is done nationwide to help gifted students and urges schools to institute honors programs. It then describes an…

  5. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... millimeters); (iii) The barge is empty and thoroughly cleaned of all debris, excessive rust, scale, mud, and... surveyor determines that sufficient cause exists, the surveyor may require that the barge be drydocked...

  6. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... millimeters); (iii) The barge is empty and thoroughly cleaned of all debris, excessive rust, scale, mud, and... surveyor determines that sufficient cause exists, the surveyor may require that the barge be drydocked...

  7. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... millimeters); (iii) The barge is empty and thoroughly cleaned of all debris, excessive rust, scale, mud, and... surveyor determines that sufficient cause exists, the surveyor may require that the barge be drydocked...

  8. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... millimeters); (iii) The barge is empty and thoroughly cleaned of all debris, excessive rust, scale, mud, and... surveyor determines that sufficient cause exists, the surveyor may require that the barge be drydocked...

  9. 46 CFR 45.183 - Load line requirements for the St. Joseph and Muskegon routes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... millimeters); (iii) The barge is empty and thoroughly cleaned of all debris, excessive rust, scale, mud, and... surveyor determines that sufficient cause exists, the surveyor may require that the barge be drydocked...

  10. Joseph Conrad's Empathy for Exploited Africans in "The Heart of Darkness."

    ERIC Educational Resources Information Center

    Farley, Ena L.

    1990-01-01

    Seemingly contradictory positions of J. Conrad as both a racist and an opponent of race-based imperial practices are discussed with reference to "The Heart of Darkness." It is argued that Conrad made a conscious effort to shake off the racial theories of the time and to deplore imperial racism. (SLD)

  11. REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3).

    PubMed

    Friedman, Joseph H; Fernandez, Hubert H; Sudarsky, Lewis R

    2003-12-01

    We reported previously that behavior suggestive of rapid eye movement sleep behavior disorder (RBD) was markedly increased in a small population of SCA-3 patients. We, therefore, asked patients and nonpatient attendees at an SCA-3 annual clinic to complete a questionnaire soliciting RBD-like behavior. Our results support the previous observation that RBD-like behaviors are significantly increased in SCA-3. PMID:14673890

  12. Food for thought: what Jim Joseph taught me about aging and nutrition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Motor and cognitive behavioral deficits occur in senescence, and in cases of severe deficits, hospitalization and/or custodial care would be a likely outcome. Unless some way is found to reduce these age-related decrements in neuronal function, health care costs will continue to rise exponentially. ...

  13. Avoiding the Hazards of Educators--A Response to Joseph Agassi.

    ERIC Educational Resources Information Center

    Sassower, Raphael

    1985-01-01

    Questions of originality and applicability do not detract from Agassi's pedagogical ideas. If there is anything educators can contribute to society, it is to help develop young critical minds that will challenge dogmas so as to find improved ones. (MT)

  14. ihear[R] Internet Therapy Program: A Program by St. Joseph Institute for the Deaf

    ERIC Educational Resources Information Center

    Broekelmann, Cheryl

    2012-01-01

    The ihear[R] Internet Therapy Program (ihear) provides effective, individualized, and interactive therapy that is tailored to each child's specific needs through a secure, high-quality Internet connection. The program brings listening and spoken language services directly to schools and families. The foundation for ihear is based on the St. Joseph…

  15. 78 FR 50098 - Notice of Inventory Completion: St. Joseph County Sheriff's Department, Centreville, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... detailed assessment of the human remains was made by the Michigan State University Forensic Anthropology... were transferred to the Michigan State University Forensic Anthropology Department where they were... American based on evaluation by the Michigan State University Forensic Anthropology Department. Pursuant...

  16. 78 FR 73749 - Proposed Amendment of Class D Airspace; St. Joseph, MO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... read as follows: ] Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class D Airspace; St....

  17. Joseph Constantine Carpue and the Bicentennial of the Birth of Modern Plastic Surgery

    PubMed Central

    Freshwater, M. Felix

    2015-01-01

    September 2014 marked the bicentennial of the birth of modern plastic surgery. It was then that Carpue began a prospective observational study of nasal reconstruction that culminated in his 1816 monograph, which caused an explosion of interest in reconstructive surgery throughout Europe. In conducting his study, Carpue demonstrated ethical standards and the power of planning a procedure. His methods to document his results accurately would remain unsurpassed until photography was adopted at the end of the 19th century. Carpue took an apocryphal story of surgery performed in India more than twenty years earlier and transformed it into the beginning of modern plastic surgery. He succeeded in a number of unrecognized tasks that are themselves landmarks not only in plastic surgical history, but surgical history: devising the first prospective observational study, using exclusion criteria, maintaining appropriate patient confidentiality, setting a standard for preoperative disclosure and ethical approval over a century before these measures were codified, having independent documentation of his preoperative and postoperative findings, devising a method to objectively monitor and document the forehead flap, and describing the potential value of tissue expansion. He shared his experience by publishing his results and by lecturing in Europe. His contemporaries recognized him for his contributions and he was honored by election to the Royal Society. Carpue launched the modern era of plastic surgery in an ethical, logical, and objective manner. While plastic surgery has changed in the last two centuries, the principles that Carpue followed remain valid. PMID:25795909

  18. A bill for the relief of Joseph Gabra and Sharon Kamel.

    THOMAS, 113th Congress

    Sen. Feinstein, Dianne [D-CA

    2013-03-18

    03/18/2013 Read twice and referred to the Committee on the Judiciary. (text of measure as introduced: CR S1898-1899) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  19. A bill for the relief of Joseph Gabra and Sharon Kamel.

    THOMAS, 112th Congress

    Sen. Feinstein, Dianne [D-CA

    2011-03-02

    03/02/2011 Read twice and referred to the Committee on the Judiciary. (text of measure as introduced: CR S1137) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. A Study of Ideational Metafunction in Joseph Conrad's "Heart of Darkness": A Critical Discourse Analysis

    ERIC Educational Resources Information Center

    Alaei, Mahya; Ahangari, Saeideh

    2016-01-01

    The linguistic study of literature or critical analysis of literary discourse is no different from any other textual description; it is not a new branch or a new level or a new kind of linguistics but the application of existing theories and methods (Halliday, 2002). This study intends to determine how ideology or opinion is expressed in Joseph…

  1. 77 FR 14441 - Facility Operating License Amendment From Southern Nuclear Operating, Inc., Joseph M. Farley...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ... ``Begin Web- based ADAMS Search.'' For problems with ADAMS, please contact the NRC's Public Document Room... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR... documents over the internet, or in some cases to mail copies on electronic storage media. Participants...

  2. Joseph Henry and John Henry Lefroy A common 19th century vision of auroral research

    NASA Astrophysics Data System (ADS)

    Silverman, S. M.

    Research on solar-terrestrial relationships today relies primarily on in situ space data. These data, however, cover only a short period of about 30 years. Many solar and related phenomena vary on much longer time scales. For the study of these, parameters such as sunspots, magnetic activity, auroral occurrence, or other proxy data are required. Historical records of aurora are particularly useful in this connection.

  3. A new understanding of the first electromagnetic machine: Joseph Henry's vibrating motor

    NASA Astrophysics Data System (ADS)

    Littman, Michael G.; Stern, Lucas E.

    2011-02-01

    In 1831, Henry invented a battery-powered rocking-beam motor that he later described as the first electromagnetic machine. He repeatedly modified the design over his career, but only one version of a motor actually constructed by Henry is known to exist. This version is in a collection of Henry instruments at Princeton University. We found that the Princeton motor cannot have operated in the form that was displayed as early as 1884. We found evidence in several historical documents and in the instrument itself that the field magnet shown with the motor is a mistake. Instead of a single horizontal bar magnet, the motor was designed to use two elliptical magnets. We presume the error was made by whoever assembled the first public display. We modeled the dynamics of Henry's vibrating motor and compared our results to the operation of a replica motor. Modeling provides insight into how the motor is able to vibrate indefinitely even in the presence of energy loss due to friction.

  4. Seagrass resource assessment using remote sensing methods in St. Joseph Sound and Clearwater Harbor, Florida, USA.

    PubMed

    Meyer, Cynthia A; Pu, Ruiliang

    2012-01-01

    In the event of a natural or anthropogenic disturbance, environmental resource managers require a reliable tool to quickly assess the spatial extent of potential damage to the seagrass resource. The temporal availability of the Landsat 5 Thematic Mapper (TM) imagery provided a suitable option to detect and assess damage of the submerged aquatic vegetation (SAV). This study examined Landsat TM imagery classification techniques to create two-class (SAV presence/absence) and three-class (SAV estimated coverage) SAV maps of the seagrass resource. The Mahalanobis Distance method achieved the highest overall accuracy (86%) and validation accuracy (68%) for delineating the seagrass resource (two-class SAV map). The Maximum Likelihood method achieved the highest overall accuracy (74%) and validation accuracy (70%) for delineating the seagrass resource three-class SAV map. The Landsat 5 TM imagery classification provided a seagrass resource map product with similar accuracy to the aerial photointerpretation maps (validation accuracy 71%). The results support the application of remote sensing methods to analyze the spatial extent of the seagrass resource.

  5. Anatomy of an Article: A Film by Sylwester Zabielski and a Case Study by Joseph Janangelo

    ERIC Educational Resources Information Center

    Zabielski, Sylwester; Janagelo, Joseph; Pearson, Jonathan; Hanlon-Baker, Patti; Greer, Jane

    2011-01-01

    This webtext examines the ways that Jonathan Pearson, a recent graduate of The University of Missouri-Kansas City, revised one of his essays to turn it from a seminar paper into a published scholarly article. The project covers a time period from 2004 to 2010 and documents the article's most important streams of input. Those streams include the…

  6. A Review of Joseph J. Mangano's Study on the Variation in Thyroid Cancer Incidence.

    PubMed

    Giardina, Paul A; Laurita, Matthew J; Shah, Shikhar K

    2015-09-01

    Researchers have attempted to link incidences of papillary thyroid cancer with radioiodine releases from nuclear power plants. Thyroid cancer detection rates are examined together with overall population exposure to ionizing radiation and actual radioiodine releases from the Indian Point Energy Center to determine if a causal relationship exists. A critical review of the statistical analyses used in previous papers is then presented. PMID:26222221

  7. Characteristics, transport, and yield of sediment in Juday Creek, St. Joseph County, Indiana, 1993-94

    USGS Publications Warehouse

    Fowler, K.K.; Wilson, J.T.

    1995-01-01

    Surveys of the instream pond determined that the volume of sediment delivered to the pond from April 1993 to April 1994 was approximately 26,500 cubic feet. The average volume weight of the sediment was determined to be 102 pounds per cubic foot. The sediment yield for the upper reach of Juday Creek from April 1993 to April 1994 was estimated to be 48 tons per square mile.

  8. Joseph A. Burton Forum Award Talk: Science and Subversion -- Experiences from Pakistan

    NASA Astrophysics Data System (ADS)

    Hoodbhoy, Pervez

    2010-02-01

    How may one exorcise the twin demons that plague human society: irrational beliefs derived from faith, and of violence and militarism? The hope for a better future goes something like this: if a society is convinced that it must develop science because it wants technology, then the teaching of science is allowed even in societies where the scientific method is not wholly welcome. Therefore, because critical inquiry is its basic tool, science can be a Trojan Horse that silently subverts and ultimately helps to win the battle for secular humanism and peace. To what extent are such hopes realistic? I shall draw upon my experiences in Pakistan to argue that good science teaching may indeed be our best bet. The battle for a peaceful, non-nuclear world will also require both a greater public understanding of science, and a commitment to work against prejudices induced by religious faith and nationhood. )

  9. Confluence: Synthesizing the Insights of Joseph Chilton Pearce and Natural Learning Rhythms.

    ERIC Educational Resources Information Center

    Luvmour, Josette; Luvmour, Ba

    1999-01-01

    A theory of childhood development posits an unseen pattern that contains the laws and principles determining the child's nature. An environment that provides attunement to this pattern allows the child profound spiritual awareness, within the limits of the developmental moment. Four stages of development are presented with their attributes,…

  10. Herbicide Losses in the Saint Joseph River Watershed: Impacts of Hydrology and Land Management

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Herbicide losses from row crop agriculture represent potential human health hazards, and are a major focus of the Conservation Effects Assessment Project (CEAP). Atrazine, simazine, alachlor, acetochlor, metolachlor, and glyphosate were monitored in tile-fed drainage ditches draining to a drinking ...

  11. Joseph A. Burton Forum Award Lecture: Managing Nuclear and Biological Risks: Building Resilience through International Cooperation

    NASA Astrophysics Data System (ADS)

    Pregenzer, Arian

    2012-03-01

    International technical cooperation has long been an important nonproliferation strategy, especially since the 1990s when cooperative threat reduction (CTR) to prevent theft or illicit transfer of nuclear weapons, material and expertise in the former Soviet Union became a keystone of U.S. policy. The CTR approach expanded to include engagement with scientists and engineers with expertise relevant to biological and chemical weapons, and continued in the 2000s with efforts in Iraq and Libya, and cooperation with a wide range of countries on export control and nuclear and biological security. In general, the goal of such efforts has been to prevent proliferation or WMD terrorism. In most cases, the United States (or the West) defines the threat, and then funds partner countries to implement solutions. This presentation will argue that the future requires a new approach. Nuclear capabilities are more widely available than ever before, repercussions of the A.Q. Khan network continue to unfurl, and countries such as the DPRK engage in illicit cooperation. In addition, there has been a global boom in biotechnology with many nations, particularly across South and East Asia, investing in the biotech industry as a source of fuels, food, and materials for their rapidly expanding populations. Compared to the 1990s, today's threat is more diffuse, and the line between legitimate and illegitimate technical capability is no longer so clear. In addition, the West has many fewer resources to invest due to the global economic downturn. In this environment, full commitment of all countries that benefit from nuclear and biological advances will be required to assure the safety and security of all. Technical cooperation can continue to play an important role, but with some significant changes: First, challenges should be defined from a local perspective to ensure full commitment and participation. Second, the goal of cooperation should shift from preventing specific threats to building general capabilities to respond to a broad range of challenges as they arise. Finally, the funding model for technical cooperation should move from contractual arrangements to mutual investment and partnership, with regional approaches encouraged to add credibility, increase available resources, and help to ensure broad support.

  12. Electron Resonance Decay into a Biological Function: Decrease in Viability of E. coli Transformed by Plasmid DNA Irradiated with 0.5-18 eV Electrons.

    PubMed

    Kouass Sahbani, S; Cloutier, P; Bass, A D; Hunting, D J; Sanche, L

    2015-10-01

    Transient negative ions (TNIs) are ubiquitous in electron-molecule scattering at low electron impact energies (0-20 eV) and are particularly effective in damaging large biomolecules. Because ionizing radiation generates mostly 0-20 eV electrons, TNIs are expected to play important roles in cell mutagenesis and death during radiotherapeutic cancer treatment, although this hypothesis has never been directly verified. Here, we measure the efficiency of transforming E. coli bacteria by inserting into the cells, pGEM-3ZfL(-) plasmid DNA that confers resistance to the antibiotic ampicillin. Before transformation, plasmids are irradiated with electrons of specific energies between 0.5 and 18 eV. The loss of transformation efficiency plotted as a function of irradiation energy reveals TNIs at 5.5 and 9.5 eV, corresponding to similar states observed in the yields of DNA double strand breaks. We show that TNIs are detectable in the electron-energy dependence of a biological process and can decrease cell viability.

  13. [Exploring Current Problems and Corresponding Strategies for Evaluation of Innovative Medical Devices in China].

    PubMed

    Du, Ranran; Ouyang, Zhaolian; Li, Yang; Yang, Yuan; Yang, Guozhong; Chi, Hui

    2015-03-01

    Through the analysis of the current status and problems of innovative medical devices evaluation, tnis paper discussed the strategies of evaluation, and ultimately raises the frame of evaluation, so as to provide reference for scientific evaluation of medical devices in China.

  14. Nerve-responsive troponin I slow promoter does not respond to unloading

    NASA Technical Reports Server (NTRS)

    Criswell, D. S.; Hodgson, V. R.; Hardeman, E. C.; Booth, F. W.

    1998-01-01

    We examined the regulation of the troponin I slow (TnIs) promoter during skeletal muscle unloading-induced protein isoform transition, by using a transgenic mouse line harboring the -4,200 to +12 base pairs region of the human TnIs promoter. Eighteen female transgenic mice ( approximately 30 g body mass) were randomly divided into two groups: weight-bearing (WB) controls (n = 9) and hindlimb unloaded (HU; n = 9). The HU mice were tail suspended for 7 days. Body mass was unchanged in the WB group but was reduced (-6%; P < 0.05) after the HU treatment. Absolute soleus muscle mass (-25%) and soleus mass relative to body mass (-16%) were both lower (P < 0.05) in the HU group compared with the WB mice. Northern blot analyses indicate that 7 days of HU result in a 64% decrease (P < 0.05) in the abundance of endogenous TnIs mRNA (microg/mg muscle) in the mouse soleus. Furthermore, there is a trend for the abundance of the fast troponin I mRNA to be increased (+34%). Analysis of transgenic chloramphenicol acetyltransferase activity in the soleus muscle revealed no difference (P > 0.05) between WB and HU groups. We conclude that additional elements are necessary for the TnIs gene to respond to an unloading-induced, slow-to-fast isoform transition stimulus.

  15. GENERAL VIEW OF MAIN STREET (HIGHWAY 82), LOOKING NORTH, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF MAIN STREET (HIGHWAY 82), LOOKING NORTH, WITH THE FIRST BANK OF JOSEPH IN THE FOREGROUND, RIGHT OF CENTER. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  16. TOPOGRAPHIC VIEW OF MAIN STREET LOOKING NORTHEAST, WITH THE FIRST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TOPOGRAPHIC VIEW OF MAIN STREET LOOKING NORTHEAST, WITH THE FIRST BANK OF JOSEPH IN THE FOREGROUND, AND THE SCHLUER BUILDING NEAR THE CENTER OF FRAME. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  17. Eponymous doctors associated with Edinburgh, Part 2--David Bruce, John Cheyne, William Stokes, Alexander Monro Secundus, Joseph Gamgee.

    PubMed

    Doyle, D

    2006-12-01

    This, the second in a three-paper series with this title, looks at famous doctors who trained in Edinburgh and their eponyms. With one possible exception, none seems to have sought the eponym, nor awarded it to themselves, nor used it for self-promotion. Unlike those in the first paper, all eponyms in this paper are still in use and their brevity is in contrast to the lengthy description needed if the eponym is not used. Examples are Cheyne-Stokes respiration, Stokes-Adam attacks, Brucellosis and Gamgee dressing. Monro Secundus is included because of his vehement defence of his professional reputation and research findings when he suspected others of trying to detract credit from him, a characteristic seldom reported for the others. PMID:17526135

  18. Arsenic and Old Mustard: Chemical Problems of Old Arsenical and 'Mustard' Munitions (Joseph F. Bunnett and Marian Mikotajczyk, Eds.)

    NASA Astrophysics Data System (ADS)

    Garrett, Benjamin

    1999-10-01

    What do Knute Rockne, Notre Dame's famed football coach, and Lewisite, a chemical warfare agent dubbed "the dew of death", have in common? Both owe their discovery to Father Julius Arthur Nieuwland.1 Rockne's legacy lives on in the Fighting Irish and their tradition of excellence on the gridiron. Lewisite, together with other arsenical- and mustard-type chemical warfare agents, provide a legacy that lives on, too, but with less cheerful consequences. The book Arsenic and Old Mustard: Chemical Problems of Old Arsenical and 'Mustard' Munitions makes clear the challenges faced in dealing with those consequences. This book documents the proceedings of a workshop devoted to arsenical- and mustard-type chemical warfare agents and their associated munitions. The workshop, held in Poland in 1996, included nine lectures, eight posters, and three discussion groups; and the contents of all these are presented. Major support for the workshop came from the Scientific Affairs Division of NATO as part of on ongoing series of meetings, cooperative research projects, and related efforts dealing with problems leftover from the Cold War and, in the case of the arsenicals and mustards, from conflicts dating to World War I. These problems can be seen in contemporary accounts, including a January 1999 news report that the U.S. Department of Defense intends to survey Washington, DC, areas near both American University and the Catholic University of America (CUA), site of the original synthesis of Lewisite, for chemical warfare agents and other materials disposed at the end of World War I.2 The first nine chapters of the book present the workshop's lectures. Of these, readers interested in chemical weapon destruction might find especially useful the first chapter, in which Ron Mansley of the Organisation for the Prohibition of Chemical Weapons presents a scholarly overview covering historical aspects of the arsenicals and mustards; their production and use; prospective destruction technologies; and international obligations attendant to the Chemical Weapons Convention, which entered into force in 1997. Hermann Martens's presentation of German arsenical and mustard munitions and of technical approaches to their destruction is similarly detailed, thorough, and engaging. W. R. Cullen's chapter "Arsenic in the Environment" and Shigeru Maeda's chapter "Biotransformation of Arsenic in Freshwater Organisms" help place the problems associated with the arsenicals in their environmental context and, hence, should appeal to a large audiencenot merely those specialists dealing with chemical weapon destruction. The reports of the three discussion groupsYperite,3 Arsenicals, and Recovered Munitionsprovide useful summaries of current knowledge and needs for additional research. The Arsenicals report observes that "destruction of arsenical agents appears to have received little attention." This situation may change if searches in Washington, DC, should uncover caches of old arsenicals at CUA and, especially, when the governments of the People's Republic of China and Japan agree on funding for destruction of the chemical munitions Japan caused to be abandoned on what is now the territory of the PRC. A conservative estimate is that there are 2,000,000 of these abandoned munitions, most of them being arsenicals and mustards.4 Notes and References 1. Nieuwland (1878-1936) hired Rockne in 1914 as a chemistry instructor. According to Father Nieuwland, Rockne owed much of his prowess as one of the greatest coaches of all time to his training in chemistry, which taught him the method of reasoning (Ind. Eng. Chem. New Ed., April 20, 1931). W. Lee Lewis, Lewisite's eponym, credits Nieuwland's unpublished dissertation as the source for his 1918 synthesis (Lewis, W. L.; Perkins, G. A. The beta-Chlorovinyl Chloroarsines; Ind. Eng. Chem. 1923, 15, 290-295). Lewisite itself is actually the group of mono-, di-, and tri-substituted 2-chloroethenyl derivatives of arsenic(III) chloride. 2. Vogel, S. Search to Resume near AU for WWI Chemicals; Washington Post, January 24, 1999, page C01. 3. Yperite is a trivial name for sulfur mustard or bis(2-chloroethyl) sulfide. The name honors Ypres, Belgium, where the Germans first used sulfur mustard as a chemical weapon on July 12, 1917. 4. Zhao, L. Two Scenes of Poisonous Shells Left Over by Japan in Dunhua, Jilin Province; presented at the Fifth International Symposium on Sino-Japan relations over the past 100 years, Changchun, PRC, September 23-29, 1998.

  19. Expanding Concepts in Mental Retardation; Scientific Symposium of the Joseph P. Kennedy, Jr., Foundation (3rd, Boston, Massachusetts, 1966).

    ERIC Educational Resources Information Center

    Jervis, George A., Ed.

    The genetics of mental retardation are discussed in terms of geographical isolates, prospects for prevention of trisomic conditions, population genetics, and cytogenetics of Down's syndrome; problems of neurogenesis described are anabolic pathways of galactose and glucose metabolism, abnormal cell migrations in developing brains, and genetic…

  20. Decalepisarayalpathra (J. Joseph & V. Chandras.) Venter, an endemic and endangered ethno medicinal plant from Western Ghats, India.

    PubMed

    Verma, Sunil K; Sarkar, Manoj K

    2015-01-01

    Decalepis arayalpatra is an endemic and critically endangered plant of India. May 2014 issue of Natural Products Research publishes the findings of R. S. Verma et al. on the chemical composition of D. arayalpatra. This study was conducted to characterise the root aroma of this plant for possible industrial applications. The authors suggest that due to its peculiar vanilla flavour, the plant could be explored as a potential substitute of vanillin-aroma in the flavour industry. Owing to the fact that D. arayalpatra is a critically endangered plant species, and its habitat is now limited to only the protected areas and reserve forest in southern part of India, and that collecting any plant from such reserve forests for commercial activities is illegal as per the law of the country, this specific conclusion of the authors is totally un-substantiated by the law of land, hence, calls for further review. PMID:25133451

  1. 75 FR 76052 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Units 1 and 2; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... environment (75 FR 73135, dated November 29, 2010). This exemption is effective upon issuance. Dated at.... Farley Nuclear Plant, Units 1 and 2 (FNP). The licenses provide, among other things, that the facility is... consistent with the approach set forth by the Commission as discussed in the June 4, 2009, letter....

  2. "Pedagogy, Identity and the Construction of a Theory of Symbolic Control": Basil Bernstein Questioned by Joseph Solomon.

    ERIC Educational Resources Information Center

    Bernstein, Basil; Solomon, Joseph

    1999-01-01

    Provides background information on Basil Bernstein and his theory of symbolic control and cultural production. Presents an interview with Bernstein addressing such topics as the concept of "pedagogy" and its role in his theory, "boundaries" as a conceptual key in his theory, and transformation of his theory. (CMK)

  3. A Historical Survey of the Contributions of Francois-Joseph Servois to the Development of the Rigorous Calculus

    ERIC Educational Resources Information Center

    Petrilli, Salvatore John, Jr.

    2009-01-01

    Historians of mathematics considered the nineteenth century to be the Golden Age of mathematics. During this time period many areas of mathematics, such as algebra and geometry, were being placed on rigorous foundations. Another area of mathematics which experienced fundamental change was analysis. The drive for rigor in calculus began in 1797…

  4. 77 FR 49835 - Order Prohibiting Involvement in NRC-Licensed Activities; In the Matter of Mr. Joseph Quintanilla

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit and serve all... were inside the darkroom). This conflicted with the inspector's observations that both men were in the... not wearing it during radiography. This conflicted with the inspector's observation that...

  5. MOOCs and Joseph Lancaster: Lessons from a Two-Hundred Year Precedent in Mass Learning on a Global Scale

    ERIC Educational Resources Information Center

    Stevenson, William R., III

    2015-01-01

    Over the past three years, Massive Open Online Courses, or MOOCs, have spanned the globe, educating millions with the potential to reach millions more. Taught by leading academics from top institutions, the courses are as complete as those offered in traditional settings; yet, in being web-based and tuition free, they disregard long-standing…

  6. Tropic Trappings in Mel Gibson's "Apocalypto" and Joseph Nicolar's "The Life and Traditions of the Red Man"

    ERIC Educational Resources Information Center

    Kolodny, Annette

    2008-01-01

    With its roots in ancient rhetoric and medieval liturgy, the term "trope" now refers to a figure of speech that organizes a set of complex ideas into a kind of linguistic shorthand. A trope is thus a phrase or image that conveys more than its literal meaning. In this article, two tropes are pertinent: the "pastoral" and the "fortunate fall." The…

  7. Description and comparison of selected models for hydrologic analysis of ground-water flow, St Joseph River basin, Indiana

    USGS Publications Warehouse

    Peters, J.G.

    1987-01-01

    The Indiana Department of Natural Resources (IDNR) is developing water-management policies designed to assess the effects of irrigation and other water uses on water supply in the basin. In support of this effort, the USGS, in cooperation with IDNR, began a study to evaluate appropriate methods for analyzing the effects of pumping on ground-water levels and streamflow in the basin 's glacial aquifer systems. Four analytical models describe drawdown for a nonleaky, confined aquifer and fully penetrating well; a leaky, confined aquifer and fully penetrating well; a leaky, confined aquifer and partially penetrating well; and an unconfined aquifer and partially penetrating well. Analytical equations, simplifying assumptions, and methods of application are described for each model. In addition to these four models, several other analytical models were used to predict the effects of ground-water pumping on water levels in the aquifer and on streamflow in local areas with up to two pumping wells. Analytical models for a variety of other hydrogeologic conditions are cited. A digital ground-water flow model was used to describe how a numerical model can be applied to a glacial aquifer system. The numerical model was used to predict the effects of six pumping plans in 46.5 sq mi area with as many as 150 wells. Water budgets for the six pumping plans were used to estimate the effect of pumping on streamflow reduction. Results of the analytical and numerical models indicate that, in general, the glacial aquifers in the basin are highly permeable. Radial hydraulic conductivity calculated by the analytical models ranged from 280 to 600 ft/day, compared to 210 and 360 ft/day used in the numerical model. Maximum seasonal pumping for irrigation produced maximum calculated drawdown of only one-fourth of available drawdown and reduced streamflow by as much as 21%. Analytical models are useful in estimating aquifer properties and predicting local effects of pumping in areas with simple lithology and boundary conditions and with few pumping wells. Numerical models are useful in regional areas with complex hydrogeology with many pumping wells and provide detailed water budgets useful for estimating the sources of water in pumping simulations. Numerical models are useful in constructing flow nets. The choice of which type of model to use is also based on the nature and scope of questions to be answered and on the degree of accuracy required. (Author 's abstract)

  8. Remarks of Joseph A. Califano, Jr., Secretary of Health, Education, and Welfare before the 1977 NRA National Conference

    ERIC Educational Resources Information Center

    Califano, Joseph A., Jr.

    1977-01-01

    Focuses on (1) some steps that President Carter and the Department of Health, Education, and Welfare (DHEW) have taken to serve handicapped Americans, (2) new efforts that are underway in DHEW, such as closed captioning for the deaf, and (3) future effectiveness of rehabilitation programs in light of inflated expenses for health and hospital care.…

  9. Experiments in Physical Chemistry, Sixth Edition (by David P. Shoemaker, Carl W. Garland, and Joseph W. Nibler)

    NASA Astrophysics Data System (ADS)

    Feigerle, Charles S.

    1997-05-01

    McGraw-Hill: New York, 1996. xii + 778 pp. ISBN 0-07-057074-4. Experiments in Physical Chemistry has long been one of the best textbooks available for undergraduate courses in physical chemistry laboratory. The present edition follows a similar format as previous editions, consisting of (i) a series of introductory sections dealing with common aspects of all experiments, such as recording of data, report writing, data and error analysis, and the use of computer software to aide in these, (ii) 48 experiments spanning 12 fundamental areas, and (iii) a series of resource chapters providing an introduction to electronics, instruments, techniques, and procedures commonly utilized in the performance of experiments in physical chemistry. Some needed changes have been incorporated in this edition, most notably the addition of sections that recognize the increased role of computers in modern experimentation. In particular, the section on computer software has been expanded and moved ahead of the experiments. The use of word processing, spreadsheets, and symbolic mathematics programs is emphasized, with examples using some of the most popular commercial programs. Three new experiments have been added and a fourth substantially modified. Each of the 44 other experiments has undergone some review and modernization, and a much-needed section on safety issues has been added to each. A resource chapter on computer interfacing, treating data types, programming languages and interfacing has been added. Examples are given for programming RS-232 communication and analog/digital interface boards using visual basic routines. I recommend this book be given serious consideration as a text for a one- or two-semester course in physical chemistry laboratory. The approach to experimentation in physical chemistry, the experiments, and the techniques that are described can form a solid basis for such a course. My one criticism is that the text offers only a limited number of laser-based experiments. This represents a minor drawback to an overall strong text, since those who wish to emphasize the use of lasers can easily supplement the choice of experiments from the numerous alternatives available in the literature.

  10. Providing Worker Education and Building the Labor Movement: The Joseph S. Murphy Institute of City University of New York

    ERIC Educational Resources Information Center

    D'Amico, Deborah

    2011-01-01

    To provide equitable access to formal, nonformal and workplace learning, experts urge community, business, education and government partnerships. While membership in unions continues to decline and "opportunities for entry-level workers to become skilled workers is lessening," the partnership described in this article shows that it is possible to…

  11. Joseph F. Keithley Award For Advances in Measurement Science: Resonant Ultrasound Spectroscopy: An Odyssey in Measurement Science

    NASA Astrophysics Data System (ADS)

    Migliori, Albert

    Perhaps the speeds of sound, or, equivalently, the elastic moduli are some of the most fundamental attributes of a solid, connecting to fundamental physics, metallurgy, non-destructive testing, and more. Unlike most of the quantities used to characterize condensed matter, the elastic moduli are fourth-rank tensors containing a wealth of detail, directional information, and consistency constraints that provide some of the most revealing probes of solids. We describe here the current state of the art in one method, Resonant Ultrasound Spectroscopy, where the mechanical resonances of a specimen of regular shape (easy to measure) are analyzed (difficult computational problem) to obtain the full elastic tensor. With modern advances in electronics and analysis, fractions of a part per million changes in elastic moduli are detectable providing new and important insight into grand challenges in condensed matter physics. This work was supported as part of the Materials Science of Actinides, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award # DE-SC0001089.

  12. Scanning Cargo Containers with Tagged Neutrons

    NASA Astrophysics Data System (ADS)

    Viesti, G.; Botosso, C.; Fabris, D.; Lunardon, M.; Moretto, S.; Nebbia, G.; Pesente, S.; Zenoni, A.; Donzella, A.; Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Sannie, G.; Valkovic, V.; Sudac, D.; Nad, K.; Peerani, P.; Sequeira, V.; Salvato, M.; Moszynski, M.; Gierlik, M.; Klamra, W.; Le Tourneur, P.; Lhuissier, M.; Colonna, A.; Tintori, C.

    2007-10-01

    A new Tagged Neutron Inspection System (TNIS) able to detect illicit materials such as explosives and narcotics in cargo containers has been developed within the EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project. After the R&D phase, the inspection portal has been installed and commissioned at the Rijeka seaport in Croatia, where it has been operated in connection with the existing X-ray scanner for a first two-month demonstration campaign. Results obtained are presented and discussed in this paper.

  13. Scanning Cargo Containers with Tagged Neutrons

    SciTech Connect

    Viesti, G.; Botosso, C.; Fabris, D.; Lunardon, M.; Moretto, S.; Nebbia, G.; Pesente, S.; Zenoni, A.; Donzella, A.; Perot, B.; Carasco, C.; Bernard, S.; Mariani, A.; Szabo, J.-L.; Sannie, G.; Valkovic, V.; Sudac, D.; Nad, K.; Peerani, P.; Sequeira, V.

    2007-10-26

    A new Tagged Neutron Inspection System (TNIS) able to detect illicit materials such as explosives and narcotics in cargo containers has been developed within the EURopean Illicit TRAfficing Countermeasures Kit (EURITRACK) project. After the R and D phase, the inspection portal has been installed and commissioned at the Rijeka seaport in Croatia, where it has been operated in connection with the existing X-ray scanner for a first two-month demonstration campaign. Results obtained are presented and discussed in this paper.

  14. ELEVATION VIEW OF THE BARNARD BUILDING AND FIRST NATIONAL BANK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ELEVATION VIEW OF THE BARNARD BUILDING AND FIRST NATIONAL BANK BUILDING, LOCATED AT 012-014 MAIN STREET, VIEW LOOKING EAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  15. 77 FR 47864 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... CONTACT: Mr. Joseph R. Levine at the Bureau of Safety and Environmental Enforcement, 381 Elden Street... joseph.levine@bsee.gov . SUPPLEMENTARY INFORMATION: OESC consists of representatives from...

  16. To designate the facility of the United States Postal Service located at 6300 N. Northwest Highway in Chicago, Illinois, as the "Officer Joseph P. Cali Post Office Building".

    THOMAS, 112th Congress

    Rep. Quigley, Mike [D-IL-5

    2016-07-07

    09/21/2016 Received in the Senate and Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  17. Joseph F. Keithley Award For Advances in Measurement Science Lecture: Thermophotonic and Photoacoustic Radar Imaging Methods for Biomedical and Dental Imaging

    NASA Astrophysics Data System (ADS)

    Mandelis, Andreas

    2012-02-01

    In the first part of this presentation I will introduce thermophotonic radar imaging principles and techniques using chirped or binary-phase-coded modulation, methods which can break through the maximum detection depth/depth resolution limitations of conventional photothermal waves. Using matched-filter principles, a methodology enabling parabolic diffusion-wave energy fields to exhibit energy localization akin to propagating hyperbolic wave-fields has been developed. It allows for deconvolution of individual responses of superposed axially discrete sources, opening a new field: depth-resolved thermal coherence tomography. Several examples from dental enamel caries diagnostic imaging to metal subsurface defect thermographic imaging will be discussed. The second part will introduce the field of photoacoustic radar (or sonar) biomedical imaging. I will report the development of a novel biomedical imaging system that utilizes a continuous-wave laser source with a custom intensity modulation pattern, ultrasonic phased array for signal detection and processing coupled with a beamforming algorithm for reconstruction of photoacoustic correlation images. Utilization of specific chirped modulation waveforms (``waveform engineering'') achieves dramatic signal-to-noise-ratio increase and improved axial resolution over pulsed laser photoacoustics. The talk will conclude with aspects of instrumental sensitivity of the PA Radar to optical contrast using cancerous breast tissue-mimicking phantoms, super paramagnetic iron oxide nanoparticles as contrast enhancement agents and in-vivo tissue samples.

  18. Applying Motivational Interviewing to School-Based Consultation: A Commentary on "Has Consultation Achieved Its Primary Prevention Potential?," an Article by Joseph E. Zins

    ERIC Educational Resources Information Center

    Blom-Hoffman, Jessica; Rose, Gary S.

    2007-01-01

    Despite a decade of advances since Zins' 1995 article on prevention, much work lies ahead to make prevention everyday consultation activities for school psychologists. To foster prevention efforts, this commentary discusses how motivational interviewing in school-based consultation (a) might peak consultees' initial interest in change, and (b)…

  19. Towards a Social History of Technological Ideas: Joseph Black, James Watt, and the Separate Condenser. An Occasional Paper on Man/Society/Technology.

    ERIC Educational Resources Information Center

    Donovan, Arthur

    This seminar paper explores the role that historians of technology can play in the reevaluation of the relationship between technical and social change. Historians of technology need to ask questions about the nontechnological aspects of society which have influenced technical change in the past. In the realm of ideas, historians should check…

  20. Joseph A. Burton Forum Award Talk: How a Physics Education has Influenced Practice and Graduate Education in Technically-Focused Quantitative Policy Analysis

    NASA Astrophysics Data System (ADS)

    Granger Morgan, M.

    2011-04-01

    In a book for the general public published a year before his death, Carl Sagan wrote, "Every time a scientific paper presents a bit of data, it's accompanied by an error bar---a quiet but instant reminder that no knowledge is complete or perfect." For those of us educated in experimental natural science such an observation seems so obvious as to hardly need saying. Yet when, after completing a PhD in experimental radio physics, I began to work on problems in environmental and energy risk and policy analysis in the early 1970s, I was amazed to find that the characterization and treatment of uncertainty was almost completely lacking in the analysis of that day. In the first part of this talk, I will briefly summarize how I, and a number of my physics-educated colleagues, have worked to rectify this situation. Doctoral education in the Department of Engineering and Public Policy (EPP) at Carnegie Mellon University has also been shaped by a number of ideas and problem-solving styles that derive from physics. These have been strengthened considerably through integration with a number of ideas from experimental social science -- a field that too many in physics ignore or even belittle. In the second part of the talk, I will describe the PhD program in EPP, talk a bit about some of its unique features, and describe a few of the problems we address.

  1. Chief Joseph Kokanee Enhancement Project; Characterization of Pump Flow at the Grand Coulee Dam Pumping Station for Fish Passage, 2004-2005 Final Report.

    SciTech Connect

    Carlson, T.; Duncan, J.; Johnson, R.

    2005-03-01

    This report describes a study conducted by Pacific Northwest National Laboratory (PNNL) for the Bonneville Power Administration to characterize the conditions fish experience when entrained in pump flow at the Grand Coulee Dam. PNNL conducted field studies at Grand Coulee Dam in 2004 using the Sensor Fish to measure the acceleration and pressure conditions that might be experienced by fish that pass through pumps at Grand Coulee Dam's Pump-Generating Plant and are transported up into the feeder canal leading to Banks Lake. The probability that fish would be struck by the Pump-Generating Plant's new nine-bladed turbines was also estimated. Our measurements showed relatively low turbulence except in the immediate vicinity of the runner environment. The lowest and highest pressures experienced by the Sensor Fish were 6.4 and 155 psi (the pressure gauge saturated at 155 psi). The probability of strike was also calculated, based on the average length of hatchery-reared juvenile kokanee (land-locked sockeye). Strike probabilities ranged from 0.0755 for 2.36-inch fish to 0.3890 for 11.8-inch fish. The probability of strike estimates indicate that the majority (77%) of recently released hatchery kokanee would be carried through the test pump without being struck and most likely with low risk of injury resulting from pressure and turbulence exposure. Of the 23% that might be struck it is expected that 60% would arrive in Banks Lake without visible external injuries. Thus more than 90% of entrained fish could be expected to arrive in Banks Lake without significant injury, assuming that no kokanee were injured or killed by pressure exposure during passage.

  2. What if Educational Inquiry Were Neither a Social Science nor a Humanities Field? Revisiting Joseph Schawb's "The Practical" in the Aftermath of the Science Wars

    ERIC Educational Resources Information Center

    Donmoyer, Robert

    2014-01-01

    The recent debates about what constitutes scientific research in Education, on the one hand, and the so-called "paradigm wars" that got played out in the final quarter of the 20th century, on the other, are more similar than different. At the center of both controversies was the relative worth of quantitative and qualitative research…

  3. To designate the United States courthouse located at 700 Grant Street in Pittsburgh, Pennsylvania, as the "Joseph F. Weis Jr. United States Courthouse".

    THOMAS, 113th Congress

    Rep. Doyle, Michael F. [D-PA-14

    2014-07-17

    12/09/2014 Received in the Senate and Read twice and referred to the Committee on Environment and Public Works. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  4. Remarks of Secretary Joseph A. Califano, Jr., Department of Health, Education, and Welfare to the American Federation of Teachers 62nd Annual Convention.

    ERIC Educational Resources Information Center

    Califano, Joseph A., Jr.

    The role and responsibility of the public schools and teachers are described with special emphasis on urban education. The advances that have been made in dealing with disadvantaged youth as well as the problems remaining are pointed out. Sources and uses of federal aid are discussed, but a warning is issued on the dangers of overdependence on the…

  5. Address by Joseph A. Califano, Jr., Secretary of Health, Education, and Welfare Before the National Interagency Council on Smokinq and Health.

    ERIC Educational Resources Information Center

    Califano, Joseph A.

    The Secretary of Health, Education, and Welfare outlines new government antismoking policies and programs, with emphasis on education and information dissemination, regulatory action, financial and other incentives, and research efforts. (MJB)

  6. Remarks of Joseph A. Califano, Jr., Secretary of Health, Education, and Welfare, Before the College Entrance Examination Board Annual Meeting, San Francisco, California, Monday, October 24, 1977.

    ERIC Educational Resources Information Center

    Califano, Joseph A., Jr.

    Recognizing the lack of public confidence in the schools, public officials and educators should discuss the proper use and limitations of competency testing and the implementation of national tests. Competency tests should be used for diagnosis, for certifying that students possess basic skills, and for public awareness. They should not be the…

  7. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Gulf of Mexico south and west of....670 Section 334.670 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west...

  8. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Gulf of Mexico south and west of....670 Section 334.670 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west...

  9. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Gulf of Mexico south and west of....670 Section 334.670 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west...

  10. Chief Joseph Kokanee Enhancement Project -- Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grand Coulee Dam Third Powerplant Forebay

    SciTech Connect

    Simmons, Mary Ann; Johnson, Robert L.; McKinstry, Craig A.; Anglea, Steven M.; Simmons, Carver S.; Thorsten, Susan L.; Lecaire, R; Francis, S

    2002-01-29

    This report describes the work conducted during the first year of a long-term study to assess the efficacy of a prototype strobe light system in eliciting a negative phototactic response in kokanee and rainbow trout. The strobe light system is being evaluated as a means to prevent entrainment (and subsequent loss) of fish at the entrance to the forebay adjacent to the third powerplant at Grand Coulee Dam. Pacific Northwest National Laboratory and the Colville Confederated Tribes are collaborating on the three-year study being conducted for the Bonneville Power Administration and the Northwest Power Planning Council.

  11. Investigation of the radiological safety concerns and medical history of the late Joseph T. Harding, former employee of the Paducah Gaseous Diffusion Plant

    SciTech Connect

    Vallario, E.J.; Wolfe, H.R.

    1981-03-01

    An ex-employee's claims that inadequate enforcement of radiation safety regulations allowed excess radiation exposure thereby causing his deteriorating health was not substantiated by a thorough investigation.

  12. Sir Francis Joseph Campbell and His Family: The First Family in Professional Services for People Who Are Blind or Visually Impaired

    ERIC Educational Resources Information Center

    Welsh, Richard L.

    2008-01-01

    The author discusses the pivotal roles of Sir Francis Campbell (1832-1914) and members of his family, especially his son Charles Campbell, in the evolution of the blindness field to a professional and reason-based service.

  13. "The Best Interests of the Child: The Least Detrimental Alternative" by Joseph Goldstein, Albert J. Solnit, Sonja Goldstein, and the late Anna Freud. Book Review.

    ERIC Educational Resources Information Center

    Garfinkel, Renee

    1998-01-01

    Reviews Goldstein and others' work concerning identification of the least harmful alternative in complex child custody situations. Notes that the book's major assumption is that children's needs are paramount and families are inviolate except in extreme cases. Maintains that the book has clear assumptions and values, recommendations following…

  14. 75 FR 50010 - Atchison Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc.), CityFed Financial Corp., Divine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ..., Inc. (n/k/a Enivid, Inc.), Genesis Worldwide, Inc., Hampton Consulting Corp., and Jake's Pizza... accurate information concerning the securities of Jake's Pizza International, Inc. because it has not...

  15. Troubles de l'hémostase en réanimation chirurgicale de l'Hôpital Universitaire Joseph Ravoahangy Andrianavalona Antananarivo

    PubMed Central

    Rasoamampianina, Lalaina Elianah; Rafanomezantsoa, Toky Andriamahefa; Rakotondrainibe, Aurélia; Rajaonera, Andriambelo Tovohery; Randriamanantany, Zely Arivelo; Alson, Olivat Rakoto; Raveloson, Nasolotsiry Enintsoa

    2015-01-01

    Les troubles de l'hémostase sont fréquemment observés en réanimation. L'objectif de cette étude est d'en déterminer l'incidence, les étiologies et la prise en charge pour en diminuer le risque de morbi-mortalité. Etude rétrospective sur une période de huit mois en réanimation chirurgicale du CHUA HUJRA. Les dossiers étudiés étaient ceux contenant tous les premiers bilans d'hémostase lors de l'admission du patient en réanimation, avec un âge supérieur à 15 ans. Etaient exclus les dossiers des post opérés (malade ayant subi une intervention chirurgicale). Les dossiers retenus pour l'étude étaient ceux qui ont présenté une ou plusieurs anomalies au niveau du bilan d'hémostase. Cent cinquante-cinq dossiers ont été colligés dont 20,64% ont présenté un trouble de l'hémostase. Les patients de sexe féminin (53,12%) étaient les plus concernés, avec une population âgée en moyenne de 49±19 ans. Trois patients (9,37%) ont présenté une notion de diathèse hémorragique à l'interrogatoire. Les différents troubles de l'hémostase étaient: une diminution du taux de prothrombine (100%), un taux de céphaline activé allongé (78,12%), un international normalized ratio élevé (43,75%) et des thrombopénies (40,62%). Chez 3,12% de ces cas, des accidents hémorragiques ont survenu. La plupart de ces troubles de l'hémostase étaient présents au décours d'hémorragies digestives (46,87%) dont la prise en charge était constituée par l'administration de vitamine K1 (68,75%) et de transfusion de plasma frais congelé (65,62%). D'autres pathologies ont été également incriminées. Une incidence de 15,62% de mortalité a été retrouvée. L'existence des troubles de l'hémostase en réanimation constitue un facteur pronostique imposant un dépistage et une prise en charge précoces et adéquats pour pouvoir en réduire le taux de mortalité. PMID:26848361

  16. A resolution to authorize representation by the Senate Legal Counsel in the case of Common Cause, et al. v. Joseph R. Biden, et al.

    THOMAS, 112th Congress

    Sen. Reid, Harry [D-NV

    2012-06-06

    06/06/2012 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S3799; text as passed Senate: CR S3799; text of measure as introduced: CR S3783) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  17. Timeless and Timely Advice: A Commentary on "Consultation to Facilitate Planned Organizational Change in Schools," an Article by Joseph E. Zins and Robert J. Illback

    ERIC Educational Resources Information Center

    Hazel, Cynthia E.

    2007-01-01

    This commentary on Zins and Illback's (1995) article, Consultation to Facilitate Planned Organizational Change in Schools, argues that the authors provided a solid foundation for well-planned, proactive, sustainable, internally-driven systemic change in schools that has yet to be widely realized. Their school organizational change model and more…

  18. Making a Difference in Research and Practice: A Commentary on "Consulting to Facilitate Planned Organizational Change in Schools," an Article by Joseph E. Zins and Robert J. Illback

    ERIC Educational Resources Information Center

    Flaspohler, Paul D.

    2007-01-01

    Zins and Illback observed in 1995 that planned organizational change processes were neglected in practice, training, and research. In the decade following publication of their article, implementation of processes and structures of planned organizational change increased dramatically. Schools and school districts continue to face increased…

  19. Imaging transcription in vivo: distinct regulatory effects of fast and slow activity patterns on promoter elements from vertebrate troponin I isoform genes

    PubMed Central

    Rana, Zaheer A; Gundersen, Kristian; Buonanno, Andres; Vullhorst, Detlef

    2005-01-01

    Firing patterns typical of slow motor units activate genes for slow isoforms of contractile proteins, but it remains unclear if there is a distinct pathway for fast isoforms or if their expression simply occurs in the absence of slow activity. Here we first show that denervation in adult soleus and EDL muscles reverses the postnatal increase in expression of troponin I (TnI) isoforms, suggesting that high-level transcription of both genes in mature muscles is under neural control. We then use a combination of in vivo transfection, live muscle imaging and fluorescence quantification to investigate the role of patterned electrical activity in the transcriptional control of troponin I slow (TnIs) and fast (TnIf) regulatory sequences by directly stimulating denervated muscles with pattern that mimic fast and slow motor units. Rat soleus muscles were electroporated with green fluorescent protein (GFP) reporter constructs harbouring 2.7 and 2.1 kb of TnIs and TnIf regulatory sequences, respectively. One week later, electrodes were implanted and muscles stimulated for 12 days. The change in GFP fluorescence of individual muscle fibres before and after the stimulation was used as a measure for transcriptional responses to different patterns of action potentials. Our results indicate that the response of TnI promoter sequences to electrical stimulation is consistent with the regulation of the endogenous genes. The TnIf and TnIs enhancers were activated by matching fast and slow activity patterns, respectively. Removal of nerve-evoked activity by denervation, or stimulation with a mismatching pattern reduced transcriptional activity of both enhancers. These results strongly suggest that distinct signalling pathways couple both fast and slow patterns of activity to enhancers that regulate transcription from the fast and slow troponin I isoforms. PMID:15528243

  20. 75 FR 47891 - Notice of Intent to Rule on Request to Release Airport Property at the Dubois Regional Airport...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ...-aeronautical airport property to Joseph and Rosemary Barber. Also, Joseph and Rosemary Barber desire to... Rosemary Barber. The ROW continues to be needed by Joseph and Rosemary Barber to access SR 830 from their property. Therefore, the Authority desires to convey their half of the former ROW to Joseph and...

  1. Amend the title so as to read: `Condemning Joseph Kony and the Lord's Resistance Army for committing crimes against humanity and mass atrocities, and supporting ongoing efforts by the United States Government and governments and regional organizations in central Africa to remove Joseph Kony and Lord's Resistance Army commanders from the battlefield.'.

    THOMAS, 112th Congress

    Sen. Coons, Christopher A. [D-DE

    2012-03-21

    08/02/2012 Resolution agreed to in Senate with an amendment and an amendment to the Title and an amended preamble by Unanimous Consent. (text: CR S6009-6010) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  2. 2250-MHz High Efficiency Microwave Power Amplifier (HEMPA)

    NASA Technical Reports Server (NTRS)

    Sims, W. Herbert; Bell, Joseph L. (Technical Monitor)

    2001-01-01

    Tnis paper will focus on developing an exotic switching technique that enhances the DC-to-RF conversion efficiency of microwave power amplifiers. For years, switching techniques implemented in the 10 kHz to 30 MHz region have resulted in DC-to-RF conversion efficiencies of 90-95-percent. Currently amplifier conversion efficiency, in the 2-3 GHz region approaches, 10-20-percent. Using a combination of analytical modeling and hardware testing, a High Efficiency Microwave Power Amplifier was built that demonstrated conversion efficiencies four to five times higher than current state of the art.

  3. 75 FR 3904 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... Denney, Assistant Vice President) 1 Memorial Drive, Kansas City, Missouri 64198-0001: 1. Verlyn Joseph Herman, Jr., and Aaron Joseph Herman, both of Norton, Kansas; as members of a family group acting...

  4. Photographic copy of photograph (circa 1927) (original print in possession ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph (circa 1927) (original print in possession of Brunner and Brunner, Architect and Engineers, Inc., St. Joseph, Missouri) VIEW OF SOUTHEAST CORNER - Old City Auditorium, 404-424 North Fourth Street, Saint Joseph, Buchanan County, MO

  5. Photocopy of photograph (original print in possession of Brunner and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (original print in possession of Brunner and Brunner, Architect and Engineers, Inc., St. Joseph, Missouri). Photographer unknown. VIEW OF EAST FRONT BEFORE ALTERATIONS - Old City Auditorium, 404-424 North Fourth Street, Saint Joseph, Buchanan County, MO

  6. 76 FR 64372 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... 20240. FOR FURTHER INFORMATION CONTACT: Mr. Joseph R. Levine at the Bureau of Safety and Environmental... or by electronic mail at joseph.levine@bsee.gov . SUPPLEMENTARY INFORMATION: OESC consists...

  7. 77 FR 75444 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ...., Washington, DC 20240. FOR FURTHER INFORMATION CONTACT: Mr. Joseph R. Levine at the Bureau of Safety and... (703) 787-1033 or by electronic mail at joseph.levine@bsee.gov . SUPPLEMENTARY INFORMATION:...

  8. 7. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer July 1966 CANDLE FACTORY ON STARBUCK COURT BEHIND JOSEPH STARBUCK HOUSE - Joseph Starbuck House, 4 New Dollar Lane, Nantucket, Nantucket County, MA

  9. 9. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer July 1966 INTERIOR OF CANDLE FACTORY BEHIND JOSEPH STARBUCK HOUSE - Joseph Starbuck House, 4 New Dollar Lane, Nantucket, Nantucket County, MA

  10. 8. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Cortlandt V. D. Hubbard, Photographer July 1966 CANDLE FACTORY ON STARBUCK COURT BEHIND JOSEPH STARBUCK HOUSE - Joseph Starbuck House, 4 New Dollar Lane, Nantucket, Nantucket County, MA

  11. 1. Historic American Buildings Survey E. W. Russell, Photographer, February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey E. W. Russell, Photographer, February 6, 1936 WROUGHT IRON FENCE AND GATE WITH CAST IRON ORNAMENTS, 251 Saint Joseph Street - 251 Saint Joseph Street (Iron Fence & Gate), Mobile, Mobile County, AL

  12. Managing Restored Wetlands in the Sacramento-San Joaquin Delta to Reduce Methane Emissions and Increase Carbon Uptake Laurie Koteen, Sara Knox, Cove Sturtevant, Joseph Verfaillie, Jaclyn Hatala, Dennis Baldocchi

    NASA Astrophysics Data System (ADS)

    Koteen, L. E.; Knox, S. H.; Sturtevant, C. S.; Verfaillie, J. G.; Matthes, J. H.; Baldocchi, D. D.

    2013-12-01

    The Sacramento-San Joaquin Delta of California is a region transformed by more than a century of agricultural practices. Beginning in the 19th century, substantial regions were first drained of water and then converted to cropland in order to take advantage of the area's rich peatland soils. In the intervening time period, soil oxidation and subsidence have led to huge peat losses of up to 10 m in some places, and river water now threatens to topple the levees that were erected to keep fields from flooding. Within this region, we have been monitoring greenhouse gas exchange of several agricultural sites, a degraded pasture, and two restored wetlands. Of these land use types, restoration of wetlands is of particular interest to Delta managers as these sites attain many of the region's most pressing ecological goals, including improved water quality, increased wildlife habitat, and soil accretion. In our current investigation, we hope to assess if wetland management activities can be implemented to achieve greenhouse gas management goals as well. While we find that the restored wetlands are able to take up and store a substantial amount of carbon via rapid growth rates, they also emit methane; a greenhouse gas 25 times more potent than CO¬2. We are currently in the process of implementing two management activities with the goals of reducing methane emissions and increasing carbon uptake. Evidence from the wetland literature indicates that periodic lowering of the water table below the soil surface can reduce wetland methane emissions by: 1. Reintroducing oxygen into the soil column. This both supports growth of the methanotrophic bacteria that consume methane produced in the anaerobic zones of the soil column, and suppresses the methanogens that produce it. 2. Re-oxidization of formerly reduced compounds in the soil, (i.e. NO3-, SO42-) which can serve as alternative terminal electron acceptors of the decomposition byproducts (i.e. H2 and acetate) that lead to methane formation. Under these conditions, it becomes more energetically favorable for alternative chemical transformations to occur in which CO2 and not CH4¬ is released. A second management activity would be implemented to see if wetland carbon uptake could be increased. As wetlands mature, perennial wetland vegetation often develops a significant thatch layer which can reduce photosynthesis of growing shoots by blocking radiation from leaf surfaces. Here we propose to remove the stalks of established vegetation. This would serve two goals: 1. Decomposing vegetation would be incorporated into the soil, leading to soil accretion, and 2. Thatch removal would liberate fledgling shoots, potentially increasing carbon uptake through subsequent seasons. A third investigation would compare CO2 and CH4 fluxes at an existing tower atop low salinity sediments with a new tower where site salinity is relatively high. This effort would inform new site selection efforts for wetland restoration projects. Sites located closer to the San Francisco Bay Area are tidally-influenced, and therefore have higher salinity than the impounded freshwater systems of our current study within the Delta region.

  13. To designate the facility of the United States Postal Service located at 113 West Jackson Street in Rich Square, North Carolina, as the "Chief Joseph E. White, Jr. Post Office Building".

    THOMAS, 113th Congress

    Rep. Butterfield, G. K. [D-NC-1

    2014-07-17

    11/18/2014 Received in the Senate and Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  14. Book Review: True genius: the life and science of John Bardeen. Lillian Hoddeson and Vicki Daitch, Joseph Henry Press, Washington, DC, 2002, 467pp., US 27.95, ISBN 0309084083

    NASA Astrophysics Data System (ADS)

    Ambegaokar, Vinay

    Chapters 2-16 of this work contain a meticulously researched recreation of the life and scientific career of John Bardeen, the only person to be awarded two Nobel Prizes in physics. The book-which has taken over a decade to complete-is based on all available archival sources, as well as extensive oral interviews with family, friends, and colleagues. It captures very well the heritage, values, passions, and personality of its hero. It also provides a broad yet detailed view of his scientific creations. He is fortunate indeed to have had such fine and dedicated biographers engaged in what they describe as a labor of love.

  15. Thoughts on "Reconsidering the Washington-Du Bois Debate: Two Black Colleges in 1910-1911" and Thoughts on "Liberalism at the Crossroads: Jimmy Carter, Joseph Califano, and Public College Desegregation."

    ERIC Educational Resources Information Center

    Edwards, Anthony

    These two papers offer critiques of two essays that appeared in "Essays in Twentieth-Century Southern Education: Exceptionalism and its Limits," edited by Wayne J. Urban. The first paper examines Linda Buchanan and Philo Hutcheson's interpretation of the debate which underscored the well-known conflict between Booker T. Washington-W.E.B. DuBois…

  16. To designate the facility of the United States Postal Service located at 1 Walter Hammond Place in Waldwick, New Jersey, as the "Staff Sergeant Joseph D'Augustine Post Office Building".

    THOMAS, 113th Congress

    Rep. Garrett, Scott [R-NJ-5

    2013-04-10

    06/18/2014 Received in the Senate and Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  17. Celebrating the 200th Anniversary of the Emigration of Joseph Priestley. Abstracts and Program for the Biennial Conference on Chemical Education (13th, Lewisburg, PA, July 31-August 4, 1994).

    ERIC Educational Resources Information Center

    American Chemical Society, Easton, PA. Div. of Chemical Education.

    Included in this proceedings are: (1) letters to conferees; (2) conference chairpersons; (3) symposia listing; (4) chemical demonstrations, listing and abstracts; (5) "birds-of-a-feather" sessions, listing and abstracts (informal sessions providing an opportunities for people with similar interests to meet); (6) workshop listings; (7) symposia…

  18. 31 CFR 359.3 - What special terms do I need to know to understand this part?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in definitive form registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe.” In the... security registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe SSN 987-65-4321.” In... registered “John Doe SSN 123-45-6789 or Joseph Doe.” In this example, John Doe and Joseph Doe are...

  19. 31 CFR 359.3 - What special terms do I need to know to understand this part?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in definitive form registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe.” In the... security registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe SSN 987-65-4321.” In... registered “John Doe SSN 123-45-6789 or Joseph Doe.” In this example, John Doe and Joseph Doe are...

  20. 31 CFR 359.3 - What special terms do I need to know to understand this part?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in definitive form registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe.” In the... security registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe SSN 987-65-4321.” In... registered “John Doe SSN 123-45-6789 or Joseph Doe.” In this example, John Doe and Joseph Doe are...

  1. 31 CFR 359.3 - What special terms do I need to know to understand this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in definitive form registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe.” In the... security registered “John Doe SSN 123-45-6789 POD (payable on death to) Joseph Doe SSN 987-65-4321.” In... registered “John Doe SSN 123-45-6789 or Joseph Doe.” In this example, John Doe and Joseph Doe are...

  2. 18. A VIEW EAST, SHOWING THE HEAVILY WOODED BANKS OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. A VIEW EAST, SHOWING THE HEAVILY WOODED BANKS OF THE ST. JOSEPH RIVER. THIS IS TYPICAL OF THE RIVERSIDE ENVIRONMENT OF THE BRIDGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  3. 20. A PHOTO IMAGE OF THE NORTH BANK OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. A PHOTO IMAGE OF THE NORTH BANK OF THE ST. JOSEPH'S RIVER IN THE VICINITY OF THE BRIDGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  4. 75 FR 51506 - Iowa Disaster Number IA-00026

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... following areas as adversely affected by the disaster. Primary Counties: Black Hawk, Boone, Buchanan... Federal Domestic Assistance Numbers 59002 and 59008) Joseph P. Loddo, Acting Associate Administrator...

  5. 75 FR 51507 - Iowa Disaster #IA-00024

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... and Economic Injury Loans): Black Hawk, Cherokee, Clayton, Decatur, Delaware, Dubuque, Fayette... economic injury is 122800. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) Joseph P....

  6. 77 FR 20647 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    .... Joseph R. Levine at the Bureau of Safety and Environmental Enforcement, 381 Elden Street, Herndon....levine@bsee.gov . SUPPLEMENTARY INFORMATION: OESC consists of representatives from industry,...

  7. 78 FR 14071 - Notice of Appointment of Members to the National Agricultural Research, Extension, Education, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Retailing and Marketing Interests,'' Nancy Childs, Professor of Food Marketing, Saint Joseph's University, Haub School of Business, Philadelphia, PA; Category S. ``Food and Fiber Processors,'' Julia Sabin,...

  8. 3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey J. Alexander, Photographer, 1971 DETAIL, ENTRANCE STOOP (LION FIGURE) - Joseph Beale House, 2301 Massachusetts Avenue, Northwest, Washington, District of Columbia, DC

  9. 77 FR 16316 - Kentucky Disaster Number KY-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ...: Jefferson, Switzerland. Kentucky: Bourbon, Clark, Fleming, Gallatin, Henry, Lewis, Nicholas, Owen, Pike... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) Joseph P. Loddo,...

  10. 7 CFR 1033.2 - Mideast marketing area.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., Delaware, Elkhart, Fayette, Fountain, Franklin, Fulton, Grant, Hamilton, Hancock, Hendricks, Henry, Howard..., Pulaski, Putnam, Randolph, Ripley, Rush, Shelby, St. Joseph, Starke, Steuben, Switzerland,...

  11. 78 FR 34701 - Illinois Disaster Number IL-00041

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ...: Primary Counties: (Physical Damage and Economic Injury Loans): Brown, Calhoun, Clark, Douglas, Henry, Pike... 59002 and 59008) Joseph P. Loddo, Associate Administrator for Disaster Assistance. BILLING CODE...

  12. 78 FR 34702 - North Dakota Disaster #ND-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ..., Cass, Cavalier, Eddy, Foster, McHenry, Pembina, Ramsey, Renville, Richland, Rolette, Towner, Traill... 135976. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) Joseph P. Loddo,...

  13. 7 CFR 1033.2 - Mideast marketing area.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Delaware, Elkhart, Fayette, Fountain, Franklin, Fulton, Grant, Hamilton, Hancock, Hendricks, Henry, Howard..., Pulaski, Putnam, Randolph, Ripley, Rush, Shelby, St. Joseph, Starke, Steuben, Switzerland,...

  14. 77 FR 41874 - Florida Disaster #FL-00071

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ..., Jefferson, Leon, Liberty, Nassau, Pinellas, Polk, Putnam, Sumter, Suwannee, Union. Georgia: Charlton, Clinch... and 59008) Joseph P. Loddo, Acting Associate Administrator for Disaster Assistance. BILLING CODE...

  15. 6. AN IMAGE LOOKING NORTH ALONG THE BRIDGE SIDEWALK, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. AN IMAGE LOOKING NORTH ALONG THE BRIDGE SIDEWALK, SHOWING THE CONCRETE BALUSTRADES, LAMP STANDARDS AND ASPHALT ROADWAY. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  16. 75 FR 3246 - Notice of Public Meeting: Northeast California Resource Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... California District manager, (530) 221-1743; or BLM Public Affairs Officer Joseph J. Fontana, (530) 252-5332... Reinvestment and Recovery Act projects, an activity update for the Black Rock Desert-High Rock Canyon-Emigrant... accommodations, should contact the BLM as provided above. Dated: January 12, 2010. Joseph J. Fontana,...

  17. 78 FR 2687 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... County Black, L.A., Rice Milling Association Inc. Office, 508 S. Monroe St., DeWitt, 12001229 Columbia... Orleans, 12001241 MISSOURI Buchanan County Ryan Block, (St. Joseph MPS (AD)) 1137-1141 Frederick Ave., Saint Joseph, 12001242 St. Louis Independent city Alligator Oil Clothing Company Building,...

  18. 77 FR 16073 - Investigations Regarding Certifications of Eligibility To Apply For Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... 81360 Robert Bosch, LLC (Union).. St. Joseph, MI........ 02/24/12 02/23/12 81361 The State Journal... Corporation Princeton, NJ......... 02/28/12 02/28/12 (State/One-Stop). 81376 Stanley Black and Decker, Townson.../12 Stop). 81386 W Scott & Co. (Workers).... St. Joseph, MO........ 03/02/12 03/01/12 81387...

  19. Teaching Invisible Culture: Classroom Practice and Theory.

    ERIC Educational Resources Information Center

    Lo Bianco, Joseph, Ed.; Crozet, Chantal, Ed.

    This collection of papers discusses what researchers and classroom teachers think and do about culture in language education. There are nine chapters in two parts. Part 1, "Culture Theory," includes the following: (1) "Common Themes" (Joseph Lo Bianco); (2) "Culture: Visible, Invisible and Multiple" (Joseph Lo Bianco); and (3) "A Conceptual…

  20. Some Radical Educational Networks of the Late Eighteenth Century and Their Influence.

    ERIC Educational Resources Information Center

    Watts, Ruth

    1998-01-01

    Examines the work of 18th-century educational reformer Anna Barbauld. Traces her links to other radical reform circles including the dissenting academy of Warrington, radical circles in East Anglia, Stoke Newington, the publisher Joseph Johnson, and Joseph and Mary Priestly. Discusses the impact of these groups on early 19th-century education.…

  1. Photographic copy of photograph of the Architect's rendering of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph of the Architect's rendering of the proposed Auditorium Building (1904-05) (original photograph in possession of Brunner and Brunner, Architect and Engineers, Inc., St. Joseph, Missouri) VIEW OF SOUTHEAST CORNER - Old City Auditorium, 404-424 North Fourth Street, Saint Joseph, Buchanan County, MO

  2. Photographic copy of the original construction drawing, dated November 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of the original construction drawing, dated November 10, 1904, from the linens in possession of Brunner and Brunner, Architects and Engineers, Inc., St. Joseph, Missouri FOURTH STREET ELEVATION - Old City Auditorium, 404-424 North Fourth Street, Saint Joseph, Buchanan County, MO

  3. 78 FR 65305 - Coleman Hydro, LLC; Notice of Application Ready for Environmental Analysis and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ...-6152; email_ gsense@cableone.net. i. FERC Contact: Joseph Hassell at (202) 502-8079; or email at joseph... Commission's eFiling system at http://www.ferc.gov/docs-filing/efiling.asp . Commenters can submit brief....gov/docs-filing/ecomment.asp . You must include your name and contact information at the end of...

  4. Perspectives on Ethnicity in New Orleans.

    ERIC Educational Resources Information Center

    Cooke, John, Ed.

    This pamphlet contains several essays on the culture and ethnic groups of New Orleans, Louisiana. Included are: (11 a discussion by Joseph Logsdon on the uniqueness of New Orleans culture, marked by its cuisine, interethnic mixtures, and its politics; (2) an article on theories of ethnicity and neo ethnicity, by Joseph V. Guillotte, III; (3) a…

  5. Returning to the Reservation: Experiences of a First Year Native American Teacher.

    ERIC Educational Resources Information Center

    Blasi, MaryJane W.

    A case study of the experiences of a Native American teacher (Joseph) during his first year of teaching examined the transition from the idealistic world of college to the stark realities of actual teaching. Data were gathered through bimonthly semistructured interviews, classroom observations, and telephone communication. Joseph picked a…

  6. Pilates and Mindfulness: A Qualitative Study

    ERIC Educational Resources Information Center

    Adams, Marianne; Caldwell, Karen; Atkins, Laurie; Quin, Rebecca

    2012-01-01

    The Pilates method as Joseph Hubertus Pilates originally defined it in the early 1920s, was called "Contrology," or the art of control, based on the ideal of attaining a complete coordination of body, mind, and spirit. Joseph Pilates's early writings emphasized the value of controlling the body rather than attending to the process of body…

  7. 12. A SIMILAR VIEW TO IN6804, TAKEN FARTHER DOWNRIVER FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. A SIMILAR VIEW TO IN-68-04, TAKEN FARTHER DOWNRIVER FROM THE SOUTH BANK. THIS VIEW SHOWS THE GRACEFUL OPEN WORK OF THE SPANDRELS, UNDER THE BRIDGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  8. 78 FR 33893 - Proposed Collection; Comment Request for Form 5306-A

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ..., 2013 to be assured of consideration. ADDRESSES: Direct all written comments to R. Joseph Durbala...: 5306-A. Abstract: This form is used by banks, credit unions, insurance companies, and trade or...: May 29, 2013. R. Joseph Durbala, IRS Supervisory Tax Analyst. BILLING CODE 4830-01-P...

  9. 4. THIS VIEW SHOWS PORTIONS OF THE EAST FACADE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. THIS VIEW SHOWS PORTIONS OF THE EAST FACADE OF THE SOUTH CAUSEWAY, AS WELL AS THE THREE OPEN ARCHES OF THE BRIDGE. LOOKING NORTHWEST FROM THE SOUTH BANK OF THE RIVER. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  10. 5. AN IMAGE LOOKING SOUTH ALONG THE SIDEWALK OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. AN IMAGE LOOKING SOUTH ALONG THE SIDEWALK OF THE BRIDGE, SHOWING THE MARINA ON THE FAR BANK, TO THE RIGHT. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  11. 14. PHOTO LOOKING SOUTH FROM HIGH GROUND ON THE NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. PHOTO LOOKING SOUTH FROM HIGH GROUND ON THE NORTH BANK OF THE RIVER. CONCRETE DETERIORATION IS QUITE APPARENT IN THIS IMAGE. - County Line Bridge, Spanning St. Joseph River at State Route 219, 0.6 mile south of U.S. Route 20, Osceola, St. Joseph County, IN

  12. 78 FR 9453 - Proposed Collection; Comment Request for Information Collection Tools

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... to R. Joseph Durbala, Internal Revenue Service, room 6129, 1111 Constitution Avenue NW., Washington...) estimates of capital or start-up costs and costs of operation, maintenance, and purchase of services to provide information. Approved: February 4, 2013. R. Joseph Durbala, IRS Reports Clearance Officer....

  13. 75 FR 51533 - Proposed Collection; Comment Request for Form 14134 and Form 14135

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... directed to R. Joseph Durbala, (202) 622-3634, at Internal Revenue Service, room 6129, 1111 Constitution... of operation, maintenance, and purchase of services to provide information. Approved: August 13, 2010. R. Joseph Durbala, IRS Tax Analyst. BILLING CODE 4830-01-P...

  14. 4. Detail view north of stone wall opening between Five ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Detail view north of stone wall opening between Five Acre Lot (foreground) and Ten Acre Lot (background) with Joseph Fry Farm complex beyond - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  15. 7. Detail view north of stone wall and wood gate ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail view north of stone wall and wood gate between Ten Acre Lot (foreground) and Barn Meadow (background) with Joseph Fry Farm complex beyond - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  16. 1. View north from StanleyBostitch property toward southern boundary/stone wall ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View north from Stanley-Bostitch property toward southern boundary/stone wall of Joseph Fry Farm with South County Trail/Route 2 to the east (right) - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  17. Composing Self on Narrative Landscapes of Sexual Difference: A Story of Wisdom and Resilience

    ERIC Educational Resources Information Center

    Estefan, Andrew; Roughley, Robert A.

    2013-01-01

    This study draws upon recent narrative inquiry research that explored the resilience experiences of 6 young same-sex-attracted men and women (4 men, 2 women; age range = 21-27). This article elucidates the story of one participant, Joseph, a 25-year-old Canadian man. As we conducted the research, Joseph's story stood out for us as having something…

  18. Interventions for Increasing the Academic Engagement of Students with Autism Spectrum Disorders in Inclusive Classrooms

    ERIC Educational Resources Information Center

    Goodman, Gay; Williams, Cathy M.

    2007-01-01

    Joseph, a student with autism in Ms. Mendez's inclusion kindergarten class, experienced difficulty attending during group activities. He spent a significant amount of time looking at his hands and quoting parts of his favorite videos. Attempts to engage Joseph resulted in vocal protests and, at times, mild aggression. Ms. Mendez realized that she…

  19. 77 FR 25437 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... collections, as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3507(a)(1)(D... FURTHER INFORMATION CONTACT: Requests for additional information should be directed to Joseph Durbala, (202) 435-7893, at the Consumer Financial Protection Bureau, (Attention: Joseph Durbala, PRA...

  20. 76 FR 11240 - Qualified Hydro 34, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ...) of the Federal Power Act (FPA), proposing to study the feasibility of the Foster Joseph Sayers Dam Hydroelectric Project to be located on Bald Eagle Creek in the vicinity of Liberty Township in Centre County... Engineers' Foster Joseph Sayers Dam and would consist of the following: (1) One vertical Kaplan turbine...

  1. Nature, Nurture, and Attention Deficit Hyperactivity Disorder.

    ERIC Educational Resources Information Center

    Faraone, Stephen V.; Biederman, Joseph

    2000-01-01

    Comments on Joseph's review of the genetics of attention deficit disorder, demonstrating errors of scientific logic and oversight of relevant research in Joseph's argument. Argues for the validity of twin studies in supporting a genetic link for ADHD and for the complementary role of nature and nurture in the etiology of the disorder. (JPB)

  2. Exchange Programs. Observations on International Educational, Cultural, and Training Exchange Programs. Testimony before the Subcommittee on International Operations, Committee on Foreign Affairs, House of Representatives. Statement of Joseph E. Kelley, Director-in-Charge, International Affairs Issues, National Security and International Affairs Division.

    ERIC Educational Resources Information Center

    Kelley, Joseph E.

    This document reports testimony at a Congressional hearing held to elicit information on international exchange programs. The testimony describes the international exchange and training or cultural programs funded partially or fully by the U.S. Government, using the 1990 report of the U.S. Information Agency (USIA). The information survey included…

  3. Microbial Extracellular Enzyme Activity and Community Assembly Processes Post Fire Disturbance Amanda Labrado, University of Texas at El Paso; Emily B. Graham, University of Colorado Boulder; Joseph E. Knelman, University of Colorado Boulder; Scott Ferrenberg, University of Colorado Boulder; Diana R. Nemergut, University of Colorado Boulder

    NASA Astrophysics Data System (ADS)

    Labrdo, A.; Knelman, J. E.; Graham, E. B.; Ferrenberg, S.; Nemergut, D. R.

    2013-12-01

    Microbes control major biogeochemical cycles and can directly impact the carbon, nitrogen, and phosphorus pools and fluxes of soils. However, many questions remain regarding when and where data on microbial community structure are necessary to accurately predict biogeochemical processes. In particular, it is unknown how shifts in microbial assembly processes may relate to changes in the relationship between community structure and ecosystem function. Here, we examine soil microbial community assembly processes and extracellular enzyme activity (EEA) at 4-weeks and 16-weeks after the Fourmile Canyon Fire in Boulder, CO in order to determine the effects of disturbance on community assembly and EEA. Microbial community structure was determined from 16S rRNA gene pyrosequencing, edaphic properties were determined using standard biogeochemical assays, and extracellular enzyme activity for β-1, 4-glucosidase (BG) and β-1, 4-N-acetylglucosaminidase (NAG) enzymes were determined using fluorimetric assays. Stepwise linear regressions were used to determine the effects of microbial community structure and edaphic factors on EEA. We determined that in 4-week post fire samples EEA was only correlated with microbial predictors. However, we observed a shift with 16-week samples in which EEA was significantly related to edaphic predictors. Null derivation analysis of community assembly revealed that communities in the 4-week samples were more neutrally assembled than communities in the 16-week samples. Together, these results support a conceptual model in which the relationship between edaphic factors and ecosystem processes is somewhat decoupled in more neutrally assembled communities, and data on microbial community structure is important to most accurately predict function.

  4. A resolution commending the African Union for committing to a coordinated military response, comprised of 5,000 troops from Uganda, the Central African Republic, the Democratic Republic of Congo, and South Sudan, in order to fortify ongoing efforts to arrest Joseph Kony and senior commanders of the Lord's Resistance Army and to stop the crimes against humanity and mass atrocities committed by them.

    THOMAS, 112th Congress

    Sen. Landrieu, Mary L. [D-LA

    2012-03-29

    03/29/2012 Referred to the Committee on Foreign Relations. (text of measure as introduced: CR S2257-2258) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. Empirical Evidence of Social and Emotional Learning's Influence on School Success: A Commentary on "Building Academic Success on Social and Emotional Learning: What Does the Research Say?," a Book Edited by Joseph E. Zins, Roger P. Weissberg, Margaret C. Wang, and Herbert J. Walberg

    ERIC Educational Resources Information Center

    Taylor, Rebecca D.; Dymnicki, Allison B.

    2007-01-01

    In Building Academic Success on Social and Emotional Learning: What does the Research Say? Zins and his colleagues presented a new way to conceptualize the impact of social and emotional learning programs on students' school success by broadening the concept to include students' attitudes, behaviors, and performance. To build on Zins' ideas, we…

  6. Irradiation of 4''x4'' NaI(Tl) detector by the 14 MeV neutrons.

    PubMed

    Sudac, D; Valkovic, V

    2010-01-01

    Within the EURopean Illicit TRAfficking Countermeasures Kit (EURITRACK) project, a new Tagged Neutron Inspection System (TNIS) has been developed and installed in the Port of Rijeka in Croatia. The system was based on the examination of sea containers with the 14 MeV neutron beam. During the operation the characteristic gamma rays were produced and measured by several 5''x5''x10'' NaI(Tl) detectors. During this procedure some of the detectors were exposed to an intensive neutron beam radiation. It was necessary to check for possible radiation damage of the NaI(Tl) scintillator during the gamma detector selection phase of the project. The 4''x4'' NaI(Tl) detector was exposed to 14 MeV neutrons for 20 h. From the presented results on energy resolution and activation measurements it could be concluded that there are no significant differences in energy resolution before and after the irradiation by 4.7x10(11) of 14 MeV neutrons. The only problem could be the high level of medium and long term induced activity in the energy region below 2 MeV.

  7. The other Dr Hooker: William Dawson Hooker (1816-40).

    PubMed

    Lambert, Harold

    2011-11-01

    William Hooker and his son Joseph were famous as botanists and as the creators of the Royal Botanic Gardens in Kew. Joseph was famous also as the friend and mentor of Charles Darwin. But there was another brother, a little older than Joseph, also a doctor and naturalist. He went to Jamaica in the interests of his health and soon died there of yellow fever. His life was short and tragic with a medical conundrum at its end but its story also illustrates many of the beliefs and concerns that preoccupied doctors in this early Victorian era. It also illustrates the close relationship between medicine and botany that prevailed then.

  8. 10. VIEW TO EAST SHOWING FIREPLACE AND PORTION OF CHIMNEY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW TO EAST SHOWING FIREPLACE AND PORTION OF CHIMNEY BREAST IN AREA FORMERLY A PARLOR IN THE NORTHEAST PORTION OF THE FIRST FLOOR. - Joseph D. Reinboth House, 412-414 Cooper Street, Camden, Camden County, NJ

  9. 6. Historic American Buildings Survey Verlin Berry, Photographer October 19, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Verlin Berry, Photographer October 19, 1977 123 NORTH MAIN STREET, DETAIL OF EXTERIOR WITH ORNAMENTAL 'K' INSIGNIA ON 123 - 121-125 North Main Street (Commercial Building), Mishawaka, St. Joseph County, IN

  10. 4. Historic American Buildings Survey (Fed.) Stanley P. Mixon. Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey (Fed.) Stanley P. Mixon. Photographer Mar. 26, 1940 (A) EXT. GEN. VIEW FROM SOUTHEAST - General Joseph Walker House, 2175 Elm Street, Stratford, Fairfield County, CT

  11. 6. Historic American Buildings Survey (Fed.) Stanley P. Mixon. Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey (Fed.) Stanley P. Mixon. Photographer Mar. 26, 1940 (B) EXT. DETAIL ENTRANCE DOORWAY - General Joseph Walker House, 2175 Elm Street, Stratford, Fairfield County, CT

  12. 7. Historic American Buildings Survey Carl Magro, Photographer May 1936, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Carl Magro, Photographer May 1936, Copied by Joseph Hill. VALVE CONTROL LEVERS ON WEST GATE - Illinois & Michigan Canal, Locks & Lockhouse, Channahon, Will County, IL

  13. 7. Historic American Buildings Survey, 1966, INTERIOR, DETAIL OF MANTEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, 1966, INTERIOR, DETAIL OF MANTEL WITH PICTURES OF RECENTLY DECEASED IN PILASTERS, IN NORTHEAST ROOM, FIRST FLOOR. - Joseph Morse House, State Route 26 & Mill Street, Eaton, Madison County, NY

  14. 49 CFR Appendix B to Part 194 - High Volume Areas

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... River Jenks, OK. Arkansas River Little Rock, AR. Black Warrior River Moundville, AL. Black Warrior River.... Joseph, MO. Missouri River Weldon Springs, MO. Missouri River New Frankfort, MO. Naches River...

  15. 49 CFR Appendix B to Part 194 - High Volume Areas

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... River Jenks, OK. Arkansas River Little Rock, AR. Black Warrior River Moundville, AL. Black Warrior River.... Joseph, MO. Missouri River Weldon Springs, MO. Missouri River New Frankfort, MO. Naches River...

  16. Success to the Third Degree.

    ERIC Educational Resources Information Center

    Joiner, Lottie L.

    2001-01-01

    Tasha Inniss, Sherry Scott Joseph, and Kimberly Weems discuss the challenges and successes of becoming the first African American women to receive doctorates in mathematics from the University of Maryland-College Park. (EV)

  17. 49 CFR Appendix B to Part 194 - High Volume Areas

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... River Jenks, OK. Arkansas River Little Rock, AR. Black Warrior River Moundville, AL. Black Warrior River.... Joseph, MO. Missouri River Weldon Springs, MO. Missouri River New Frankfort, MO. Naches River...

  18. 49 CFR Appendix B to Part 194 - High Volume Areas

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... River Jenks, OK. Arkansas River Little Rock, AR. Black Warrior River Moundville, AL. Black Warrior River.... Joseph, MO. Missouri River Weldon Springs, MO. Missouri River New Frankfort, MO. Naches River...

  19. 49 CFR Appendix B to Part 194 - High Volume Areas

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... River Jenks, OK. Arkansas River Little Rock, AR. Black Warrior River Moundville, AL. Black Warrior River.... Joseph, MO. Missouri River Weldon Springs, MO. Missouri River New Frankfort, MO. Naches River...

  20. NOAA Looks for Advice to Make Its Data Easier to Use

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2014-03-01

    "There is no sector in American business that wouldn't like to have better environmental information," said Joseph Klimavicz, chief information officer for the National Oceanic and Atmospheric Administration (NOAA).