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Sample records for joseph m. farley-2 reactor

  1. 75 FR 73135 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... effect radiation exposures to plant workers and members of the public. The proposed action does not... are needed. No effects on the aquatic or terrestrial habitat in the vicinity of the plant, or to... COMMISSION Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment...

  2. IN MEMORIAM Joseph M Marshall (6 September 1943-15 December 2008)

    NASA Astrophysics Data System (ADS)

    2010-11-01

    Joseph M Marshall Joseph M Marshall graduated as BSc Hons. Physics, Sheffield, UK in 1965 and got a PhD degree in Edinburgh in 1970. In the same year he became Research Fellow in the University of Edinburgh, UK, then Lecturer (1974), Senior Lecturer (1981) and Reader (1984) in the University of Abertay Dundee. In 1987 he took the position of Professor of Electronic Materials in the University of Wales Swansea, UK and in 2002 became Emeritus Professor in the same University. His scientific papers (over 180) span three areas: Experimental and theoretical studies of the conductive, photoconductive and other properties of crystalline, polycrystalline, amorphous and organic semiconductors; Computer based numerical modelling of carrier transport and other properties of semiconducting materials and electronic devices; Design, fabrication and characterisation of thin-film sensor devices and systems, for applications in information technology, medicine, automotive industry, etc. He was Member of the Organising Committee of the annual Chelsea Conferences on Amorphous and Liquid Semiconductors (London, UK), Scientific Chairman of the Organising Committee of the 1990-2008 Biennial International Schools on Condensed Matter Physics (Varna, Bulgaria), Finance Chairman of the 1993 International Conference on Amorphous Semiconductors (Cambridge, UK), Co-Director of the 2001 NATO Advanced Study Institute 'Photovoltaic and Photoactive Materials - Properties, Technology and Applications' (Sozopol, Bulgaria) and co-editor of their Proceedings. He was a recipient of the Marin Drinov Medal of the Bulgarian Academy of Sciences (1998) and the Georgi Nadjakov Sign of Honour of the Institute of Solid State Physics (2005).

  3. 99mTc-DMSA Uptake in a Sister Mary Joseph's Nodule From Ovarian Cancer.

    PubMed

    Naddaf, Sleiman; Azzumeea, Fahad; Fahad Alzayed, Mohammed

    2016-12-01

    A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.

  4. 77 FR 14441 - Facility Operating License Amendment From Southern Nuclear Operating, Inc., Joseph M. Farley...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ... Licensing Branch 2-1, Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation, U.S... Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE 7590-01-P ... From the Federal Register Online via the Government Publishing Office NUCLEAR...

  5. Sister Mary Joseph Nodules on 99mTc HYNIC-TOC scintigraphy in patients with neuroendocrine tumors.

    PubMed

    Jing, Hongli; Zhang, Yingqiang; Li, Fang

    2015-02-01

    A Sister Mary Joseph nodule represents an umbilical metastasis, which is more commonly caused by a primary malignancy in gastrointestinal tract or from reproductive system. We report Sister Mary Joseph nodules caused by neuroendocrine tumor and revealed on Tc HYNIC-TOC scintigraphy.

  6. Joseph Ames

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Dr. Joseph Sweetman Ames at his desk at the NACA headquarters. Dr. Ames was a founding member of NACA (National Advisory Committee for Aeronautics), appointed by President Woodrow Wilson in 1915. Ames took on NACA's most challenging assignments but mostly represented physics. He chaired the Foreign Service Committee of the newly-founded National Research Council, oversaw the NACA's patent cross-licensing plan that allowed manufacturers to share technologies. Ames expected the NACA to encourage engineering education. He pressed universities to train more aerodynamicists, then structured NACA to give young engineers on-the-job training. Ames gave the NACA a focused vision that was research-based and decided that aerodynamics was the most important field of endeavor. He championed the work of theorists like Max Munk. The world class wind tunnels at Langley Aeronautical laboratory reflected his vision as well as the faith Congress put in him. Ames became chairman of the NACA main committee in 1927. Two years later he accepted the Collier Trophy on behalf on the NACA. He kept the NACA alive when Herbert Hoover tried to eliminate it and transfer its duties to industry. Ames accepted a nomination by Air Minister Hermann Goring to the Deutsche Akademie der Luftfartforschung. Ames then considered it an honor, many Americans did, and was surprised to learn about the massive Nazi investment in aeronautical infrastructure, then six times larger than the NACA. Ames urged the funding for a second laboratory and expansion of the NACA facilities to prepare for war. A stroke in May 1936 paralyzed the right side of his body. He immediately resigned as chairman of the NACA executive committee and in October 1937 he resigned from the NACA main committee. On June 8, 1944 the NACA officially dedicated its new laboratory in Sunnyvale California to Joseph S. Ames. Ames died in 1943, having never stepped foot in the new laboratory that bears his name; the Ames Aeronautical Laboratory

  7. University Reactor Conversion Lessons Learned Workshop for Texas A&M University Nuclear Science Center Reactor

    SciTech Connect

    Eric C. Woolstenhulme; Dana M. Meyer

    2007-04-01

    The objectives of this meeting were to capture the observations, insights, issues, concerns, and ideas of those involved in the Texas A&M University Nuclear Science Center (TAMU NSC) TRIGA Reactor Conversion so that future efforts can be conducted with greater effectiveness, efficiency, and with fewer challenges. This workshop was held in conjunction with a similar workshop for the University of Florida Reactor Conversion. Some of the generic lessons from that workshop are included in this report for completeness.

  8. Integral fast reactor safety tests M2 and M3 in TREAT

    SciTech Connect

    Robinson, W.R.; Lo, R.K.; Wright, A.E.; Bauer, T.H.; Stanford, G.S.; Morman, J.A.

    1985-11-01

    Transient Reactor Test Facility (TREAT) tests M2 and M3 were performed to obtain information on two key fuel behavior characteristics of transient overpower conditions in metal-fueled fast reactors: the margin to cladding breach and the axial self-extrusion of fuel within intact cladding. Cladding breach depends on penetration of a fuel/cladding eutectic into the cladding as well as on internal pin pressure. Driving forces for fuel extrusion are fission gas, liquid sodium, and volatile fission products trapped within the fuel. Significant fuel extrusion prior to cladding breach would be an important factor in the case for benign termination of unprotected overpower events in a fast reactor. These preliminary tests in the Integral Fast Reactor (IFR) program were done on uranium-5% fissium Experimental Breeder Reactor II Mark-II driver fuel pins having an active fuel column length of 34 cm.

  9. UWTOR-M, a stellarator power reactor utilizing modular coils

    SciTech Connect

    Sviatoslavsky, I.N.; Van Sciver, S.W.; Kulcinski, G.L.

    1981-10-01

    We briefly describe the parametric considerations which led to the UWTOR-M reference design point. The design has 18 twisted coils utilizing a multipolarity of 3, a major radius of 24 m, a coil radius of 4.77 m and a plasma aspect ratio of 14. An assumed ..beta.. of 5% was used. This configuration leads to a rotational transform on the edge of 1.125 giving favorable plasma physics conditions. The natural stellarator divertor is used for impurity control in conjunction with innovative high performance divertor targets. A unique blanket design is proposed which minimizes tritium inventory in the reactor. Finally, since maintainability is a prime consideration, we describe a scheme for servicing the first wall/blanket and other reactor components.

  10. UCN source with superfluid helium at WWR-M reactor

    NASA Astrophysics Data System (ADS)

    Serebrov, A. P.; Lyamkin, V. A.; Fomin, A. K.; Prudnikov, D. V.; Samodurov, O. Yu; Kanin, A. S.

    2017-01-01

    The WWR-M reactor at PNPI is going to be equipped with an ultracold neutron source of high density. Method of UCN production is based on their accumulation in the super fluid helium due to particular qualities of that quantum liquid. The satisfying storage time of UCN at WWR-M reactor in the super fluid helium exists at a temperature below 1.2 K. Our source aims at obtaining a density of UCN equals to 104 n/cm3, two orders of magnitude exceeding that in existing sources presently available in the world. Increase in the density of UCN will raise the accuracy of the measurement of the neutron electric dipole moment (EDM) of an order of magnitude, which is fundamentally important for the problem of CP violation. The most intense sources of UCN allows PNPI become the centre of fundamental researches with ultracold neutrons.

  11. Instructor Interviews Joseph Featherstone.

    ERIC Educational Resources Information Center

    Instructor, 1987

    1987-01-01

    An interview with Joseph Featherstone, a teacher at Michigan State University, reveals his attitudes regarding good teaching. Good teaching is a victory over meaninglessness, giving children the chance to hope and to have faith in their future. (CB)

  12. Modular coil design for UWTOR-M stellarator reactor

    SciTech Connect

    Yuan, K.Y.; Sanders, R.; Sviatoslavsky, I.N.; Van Sciver, S.W.

    1982-12-01

    The latest developments in the conceptual modular coil design for UWTOR-M stellarator reactor are presented. The emphasis in the design is toward the modularity, maintainability and technology feasibility of the discrete windings. The stress and deformation of the coils are calculated and overall compatibility of the various components studied. The results show that all the preliminary design objectives can be met with reaaonable cross sectional dimensions of the magnet structure. Although more refined studies are needed for the structural details, the study indicates that the envisaged design is feasible with moderate extrapolations to the present day technology.

  13. Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.

    PubMed

    Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P

    2016-01-28

    A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  14. Joseph Conrad: International Narrator

    ERIC Educational Resources Information Center

    Walker, George

    2004-01-01

    This article discusses the contribution made by Joseph Conrad's fictional writing to our understanding of cultural awareness. Never comfortable with his adopted English culture, Conrad used his experiences in different parts of the world during his career in the merchant navy to explore in his writing aspects of cultural dissonance and cultural…

  15. Jean Baptiste Joseph Fourier

    NASA Astrophysics Data System (ADS)

    Sterken, C.

    2003-03-01

    This paper gives a short account of some key elements in the life of Jean Baptiste Joseph Fourier (1768-1830), specifically his relation to Napoleon Bonaparte. The mathematical approach to Fourier series and the original scepticism by French mathematicians are briefly illustrated.

  16. Joseph Conrad: International Narrator

    ERIC Educational Resources Information Center

    Walker, George

    2004-01-01

    This article discusses the contribution made by Joseph Conrad's fictional writing to our understanding of cultural awareness. Never comfortable with his adopted English culture, Conrad used his experiences in different parts of the world during his career in the merchant navy to explore in his writing aspects of cultural dissonance and cultural…

  17. Preliminary magnet design for a stellarator fusion reactor. [UWTOR-M reactor

    SciTech Connect

    Van Sciver, S.W.; Derr, J.; Shalil, A.; Sviatoslavsky, I.N.

    1981-09-01

    Conceptual design of the superconducting magnets for a stellarator fusion power reactor UWTOR-M are presented. The emphasis in the magnet design is toward modularity and maintainability by approximating the continuous helical coil geometry with a number of discrete windings. Magnetic field requirements are reasonable (B/sub max/ approximately 10 T) allowing for modest extrapolations of present technology. The unique features of the design are: (1) use of NbTiTa with superfluid helium cooling to achieve high current density cryo-stability; (2) a monolithic conductor, made possible by the lack of pulsed magnetic fields; and (3) an innovative construction technique required by nonaxisymmetric geometry of the magnets. 8 refs.

  18. Measurement of prompt neutron generation time at the VIR-2M pulsed nuclear reactor

    NASA Astrophysics Data System (ADS)

    Glukhov, L. Yu.; Kotkov, S. P.; Kuznetsov, M. S.; Chursin, S. S.

    2016-12-01

    The prompt neutron generation time is measured in the core of the VIR-2M research nuclear reactor. The measurements are performed using the Babala method while the reactor is in the subcritical state. The VIR-2M reactor and the relevant experimental equipment are briefly described, and the experimental procedure and data processing technique are presented. It is shown that the prompt neutron generation time with empty experimental channels is 35 ± 1 μs.

  19. Measurement of prompt neutron generation time at the VIR-2M pulsed nuclear reactor

    SciTech Connect

    Glukhov, L. Yu.; Kotkov, S. P.; Kuznetsov, M. S.; Chursin, S. S.

    2016-12-15

    The prompt neutron generation time is measured in the core of the VIR-2M research nuclear reactor. The measurements are performed using the Babala method while the reactor is in the subcritical state. The VIR-2M reactor and the relevant experimental equipment are briefly described, and the experimental procedure and data processing technique are presented. It is shown that the prompt neutron generation time with empty experimental channels is 35 ± 1 μs.

  20. UWTOR-M, a conceptual design study of a modular stellarator power reactor

    SciTech Connect

    Sviatoslasky, I.N.; Van Sciver, S.W.; Kulcinski, G.L.

    1981-01-01

    A preliminary design of a 5500 MW/sub th/ modular stellarator power reactor, UW-TOR-M, is presented the parametric considerations which led to the UWTOR-M reference design point are briefly describe. A unique blanket design is proposed which minimized tritium inventory in the reactor. Finally, sine maintainability is a prime consideration, a scheme for is described servcing the first wall/blanket and other reactor components.

  1. Joseph Lister's first operation

    PubMed Central

    Richardson, Ruth; Rhodes, Bryan

    2013-01-01

    Joseph Lister was still a medical student in 1851 when he served as house surgeon at University College Hospital, London, under John Erichsen. Here we report the first major operation that Lister accomplished, hitherto apparently missed by biographers. We chart his exemplary dealings with an emergency case of eviscerating stab wound in a woman brought to casualty at night, when he had been in post for less than a month. The case demonstrates Lister's fundamental competence at an early stage in his training. We outline the context of debate and controversy over the repair of lacerated gut at the time, and argue that Lister's period at University College London was profoundly formative.

  2. 2. Historic American Buildings Survey Joseph Hill, Photographer May 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer May 10, 1936 CAST IRON GATE AT 1352 W. Washington Blvd., Chicago - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  3. 6. Historic American Buildings Survey Joseph Hill, Photographer April 1, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Joseph Hill, Photographer April 1, 1936 MANTEL 1352 W. Washington Blvd., Chicago - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  4. Joseph Priestley's Legacy in America.

    ERIC Educational Resources Information Center

    McMeekin, Dorothy

    2001-01-01

    Discusses the life and work of Joseph Priestley, a scientist of the late eighteenth century who was famous for his work in both Europe and America. Includes a description of the Joseph Priestley house, a museum containing some of his scientific equipment and exhibitions relating to his work. (MM)

  5. Joseph Conrad's "Lord Jim": Reconsiderations

    ERIC Educational Resources Information Center

    Al-Haj, Ali Albashir Mohammed

    2014-01-01

    The present study aims at reconsidering critically Joseph Conrad's "Lord Jim." Joseph Conrad is a great master of English prose who writes normally of the sea, of the Eastern islands, of the English character as seen against a background of the exotic or faced with difficulties. The power of Conrad's feelings for Jim, as well as the…

  6. Joseph Priestley's Legacy in America.

    ERIC Educational Resources Information Center

    McMeekin, Dorothy

    2001-01-01

    Discusses the life and work of Joseph Priestley, a scientist of the late eighteenth century who was famous for his work in both Europe and America. Includes a description of the Joseph Priestley house, a museum containing some of his scientific equipment and exhibitions relating to his work. (MM)

  7. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED BETWEEN JOSEPH AND SECOND AVENUE ON MAIN STREET. VIEW LOOKING SOUTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  8. Machado-Joseph disease.

    PubMed

    Sudarsky, L; Coutinho, P

    1995-01-01

    Machado-Joseph disease (MJD) is a form of dominantly-inherited ataxia originally described in people of Azorean and Portuguese descent. The disorder has subsequently been identified in Japan, Brazil, Australia, and China. Average age of onset is 35 to 40. Core features include progressive ataxia, dysarthria, postural instability, nystagmus, eyelid retraction, and facial fasciculations. Dystonia is often prominent in younger patients. Three distinct phenotypes appear to reflect the clinical spectrum of a single mutant gene. Neuropathology involves afferent and efferent cerebellar systems, with preservation of cerebellar cortex and inferior olive. Spinocerebellar pathways, substantia nigra, and cranial nerve motor nuclei are involved. The disorder is due to an unstable CAG repeat on chromosome 14q32.1. A dominantly inherited ataxia (SCA-3) in families of French and German descent has also been linked to this segment of chromosome 14. The relationship between MJD and the other dominant inherited ataxias is discussed.

  9. Joseph Henry and Astronomy

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    2016-01-01

    Joseph Henry (1797-1878) is best known for his work in electromagnetism and as the first secretary of the Smithsonian Institution. But he was also a pioneer solar physicist, an early advocate of US participation in astrophysics, and a facilitator of international cooperation in astronomy. This paper will briefly trace his role in the development of the US astronomical community from the time he taught astronomy at Princeton in the 1830s through his death, focusing on failed efforts to persuade US astronomers and patrons of astronomy that the best path for US astronomy should be astrophysics. He thought that the US could make a more significant contribution to astronomy science by striking out on a less travelled path rather than competing with the established European observatories.

  10. Production of Sn-117m in the BR2 and HFIR Research Reactors

    SciTech Connect

    Ponsard, B.; Srivastava, S.; Garland, M.; Knapp, R.; Mirzadeh, S.; Mausner, L.F.

    2009-07-01

    The BR2 reactor is a 100 MW{sub th} high-flux 'materials testing reactor', which produces a wide range of radioisotopes for various applications in nuclear medicine and industry. Tin-117m ({sup 117m}Sn), a promising radionuclide for therapeutic applications, and its production have been validated in the BR2 reactor. In contrast to therapeutic beta emitters, {sup 117m}Sn decays via isomeric transition with the emission of monoenergetic conversion electrons which are effective for metastatic bone pain palliation and radiosynovectomy with lesser damage to the bone marrow and the healthy tissues. Furthermore, the emitted gamma photons are ideal for imaging and dosimetry.

  11. Conceptual design of a new homogeneous reactor for medical radioisotope Mo-99/Tc-99m production

    NASA Astrophysics Data System (ADS)

    Liem, Peng Hong; Tran, Hoai Nam; Sembiring, Tagor Malem; Arbie, Bakri

    2014-09-01

    To partly solve the global and regional shortages of Mo-99 supply, a conceptual design of a nitrate-fuel-solution based homogeneous reactor dedicated for Mo-99/Tc-99m medical radioisotope production is proposed. The modified LEU Cintichem process for Mo-99 extraction which has been licensed and demonstrated commercially for decades by BATAN is taken into account as a key design consideration. The design characteristics and main parameters are identified and the advantageous aspects are shown by comparing with the BATAN's existing Mo-99 supply chain which uses a heterogeneous reactor (RSG GAS multipurpose reactor).

  12. UWTOR-M - a conceptual design study of a modular stellarator power reactor

    SciTech Connect

    Sviatoslavsky, I.; Van Sciver, S.W.; Kulcinski, G.L.; Anderson, D.T.; Bailey, A.W.; Callen, J.D.; Derr, J.A.; Emmert, G.A.; El-Guebaly, L.; Khalil, A.; Shohet, J.L.; Sze, D.K.; Sanders, R.C.; Tataronis, J.A.

    1981-12-01

    A preliminary design of a 5500 MW/sub th/ modular stellarator power reactor, UWTOR-M, is presented. Discrete twisted coils are used in an l.3 configuration with maintainability as a prime consideration. The natural stellarator divertor is used for impurity control in conjunction with innovative high performance divertor targets. A unique blanket design is proposed which minimizes the overall tritium inventory in the reactor. Finally, a scheme for maintaining the first wall/blanket and other reactor components is discussed. 17 refs.

  13. Joseph (Joe) A. Walker

    NASA Technical Reports Server (NTRS)

    1956-01-01

    In March 1945 Joseph A. Walker joined the National Advisory Committee for Aeronautics' Aircraft Engine Research Laboratory, Cleveland, Ohio, (later NASA's Lewis Research Center, now the Glenn Research Center) as a physicist. He transferred to the NACA High-Speed Flight Research Station, Edwards, California in 1951, as a research pilot. For the next fifteen years Walker served as a pilot at the Edwards flight research facility (today known as NASA's Dryden Flight Research Center) on such projects as the Bell X-1#2 (2 flights, first on August 27, 1951), Bell X-1A (1 flight on July 20, 1955), X-1E (21 flights, first on December 12, 1955), Douglas D-558-I #3 Skystreak (14 flights, first on June 29, 1951), Douglas D-558-II #2 Skyrocket (3 flights, first on April 29, 1955), Douglas D-558-II #3 Skyrocket (2 flights, first on May 7, 1954). On the Douglas X-3, Joe was project pilot and made all 20 flights, the first on August 1, 1954. Joe considered this aircraft the 'worst' plane he ever flew. He flew the Northrup X-4 (2 flights, first on October 18, 1951), Bell X-5 (78 flights, first on January 9, 1952). He also flew programs involving the F-100, F-101, F-102, F-104 and the B-47. Walker made the first NASA flight on the North American X-15 on March 25, 1960. His 25th and final X-15 flight on August 22, 1963, reached 354,200 feet, an unofficial record altitude of almost 67 miles. On October 30, 1964, Walker took the first Bell Lunar Landing Research Vehicle (LLRV) on its maiden flight, reaching a peak altitude of 10 feet and a free flight time of just under one minute. Two LLRV's and three Lunar Landing Training Vehicles developed from them were used to develop piloting and operational techniques for lunar landings. In November, he left the program after 35 flights on the first LLRV. Walker flew chase flights as well as research flights. On June 8, 1966 he was flying chase in NASA's F-104N for the Air Force's experimental bomber, North American XB-70A, when he was fatally

  14. REACTOR

    DOEpatents

    Szilard, L.

    1963-09-10

    A breeder reactor is described, including a mass of fissionable material that is less than critical with respect to unmoderated neutrons and greater than critical with respect to neutrons of average energies substantially greater than thermal, a coolant selected from sodium or sodium--potassium alloys, a control liquid selected from lead or lead--bismuth alloys, and means for varying the quantity of control liquid in the reactor. (AEC)

  15. REACTOR

    DOEpatents

    Christy, R.F.

    1961-07-25

    A means is described for co-relating the essential physical requirements of a fission chain reaction in order that practical, compact, and easily controllable reactors can be built. These objects are obtained by employing a composition of fissionsble isotope and moderator in fluid form in which the amount of fissionsble isotcpe present governs the reaction. The size of the reactor is no longer a critical factor, the new criterion being the concentration of the fissionable isotope.

  16. A molten Salt Am242M Production Reactor for Space Applications

    NASA Technical Reports Server (NTRS)

    Emrich, William

    2005-01-01

    The use of Am242m holds great promise for increasing the efficiency nuclear thermal rocket engines. Because Am242m has the highest fission cross section of any known isotope (1000's of barns), its extremely high reactivity may be used to directly heat a propellant gas with fission fragments. Since this isotope does not occur naturally, it must be bred in special production reactors designed for that purpose. The primary advantage to using molten salt reactors for breeding Am242m is that the reactors can be reprocessed continually yielding a constant rate of production of the isotope. Once built and initially fueled, the reactor will continually breed the additional fuel it needs to remain critical. The only feedstock required is a salt of U238. No enriched fuel is required during normal operation and all fissile material, except the Am242m, is maintained in a closed loop. For a reactor operating at 200 MW several kilograms of Am242m may be bred each year.

  17. REACTOR

    DOEpatents

    Roman, W.G.

    1961-06-27

    A pressurized water reactor in which automatic control is achieved by varying the average density of the liquid moderator-cooiant is patented. Density is controlled by the temperature and power level of the reactor ftself. This control can be effected by the use of either plate, pellet, or tubular fuel elements. The fuel elements are disposed between upper and lower coolant plenum chambers and are designed to permit unrestricted coolant flow. The control chamber has an inlet opening communicating with the lower coolant plenum chamber and a restricted vapor vent communicating with the upper coolant plenum chamber. Thus, a variation in temperature of the fuel elements will cause a variation in the average moderator density in the chamber which directly affects the power level of the reactor.

  18. PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF THE FIRST BANK OF JOSEPH, LOCATED AT THE NORTHEAST CORNER OF SECOND AND MAIN, VIEW LOOKING NORTHEAST. - Joseph Main Street, Between Joseph & Second Avenues, Joseph, Wallowa County, OR

  19. REACTORS

    DOEpatents

    Spitzer, L. Jr.

    1961-10-01

    Thermonuclear reactors, methods, and apparatus are described for controlling and confining high temperature plasma. Main axial confining coils in combination with helical windings provide a rotational transform that avoids the necessity of a figure-eight shaped reactor tube. The helical windings provide a multipolar helical magnetic field transverse to the axis of the main axial confining coils so as to improve the effectiveness of the confining field by counteracting the tendency of the more central lines of force in the stellarator tube to exchange positions with the magnetic lines of force nearer the walls of the tube. (AEC)

  20. 76 FR 11291 - University of New Mexico AGN-201M Reactor Notice of Issuance of Renewed Facility Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ..., New Mexico. The UNMR is a solid homogeneous core research reactor licensed to operate at a steady... Nuclear Regulatory Commission. Jessie Quichocho, Chief, Research and Test Reactors Licensing Branch... COMMISSION University of New Mexico AGN-201M Reactor Notice of Issuance of Renewed Facility Operating...

  1. ASK Talks With Joseph Rothenberg

    NASA Technical Reports Server (NTRS)

    Rothenberg, Joseph

    2002-01-01

    Recently retired NASA administrator Joseph Rothenberg reflects on project management during the Apollo era at the start of his career, as well as the history of, and changes in, project management over his years at NASA. He concludes by describing what he sees as NASA's most important needs in the near future.

  2. Where was Joseph Babinski born?

    PubMed

    Teive, Hélio A G; Munhoz, Renato P; de Souza, Leonardo Cruz

    2011-01-01

    There is controversy in the neurological literature about where Joseph Babinski was born, including a myth propounded by various important authors that he was born in Lima, Peru. However, according to the most consistent biographical data, he was in fact born in Paris, France, and became a medical celebrity there and in Poland as well as around the world.

  3. Renovation status of neutron radiography facility at TRR-1/M1 reactor

    NASA Astrophysics Data System (ADS)

    Picha, R.; Channuie, J.; Liamsuwan, T.; Promping, J.; Ratanatongchai, W.; Wonglee, S.

    2017-06-01

    Thai Research Reactor-1/Modification 1 (TRR-1/M1) at Thailand Institute of Nuclear Technology (TINT) has a beamline facility dedicated for neutron radiography (NR) research. The renovation has been ongoing to enhance the radiation safety and to facilitate research operations of the only reactor NR station in the country. The design of beam shutter and shielding walls has been conducted using Monte Carlo simulations along with attenuation measurements in the lab to ensure the shielding capability of the components and efficient operation. The progress and future plans TINT NR will be presented.

  4. SCC and corrosion evaluations of the F/M steels for a supercritical water reactor

    NASA Astrophysics Data System (ADS)

    Hwang, Seong Sik; Lee, Byung Hak; Kim, Jung Gu; Jang, Jinsung

    2008-01-01

    As one of the Generation IV nuclear reactors, a supercritical water cooled reactor (SCWR) is being considered as a candidate reactor due to its high thermal efficiency and simple reactor design without steam generators and steam separators. For the application of a structural material to a core's internals and a fuel cladding, the material should be evaluated in terms of its corrosion and stress corrosion cracking susceptibility. Stress corrosion cracking and general corrosion tests of ferritic-martensitic (F/M) steels, high Ni alloys and an oxide dispersion strengthened (ODS) alloy were performed. Stress corrosion cracking (SCC) was not observed on the fractured surface of the T 91 steel in the supercritical water at 500, 550 and 600 °C. As the test temperature increased, the ultimate tensile strength (UTS) and yield strength (YS) of T 91 decreased, and a high dissolved oxygen level induced corrosion and low ductility. The F/M steels showed a high corrosion rate whereas the Ni base alloys showed a little corrosion at 500 and 550 °C. Corrosion rate of the F/M steels at 600 °C test was up to three times larger than that at 500 °C. A thin layer composed of Mo and Ni seems to retard the Cr diffusion into the out layer of the corrosion product of T 92 and T 122.

  5. A conversation with Joseph Lau.

    PubMed

    Lau, Joseph; Cappelleri, Joseph C; Ingerick, Meghan

    2015-03-01

    Dr. Joseph Lau is a world-leading expert in meta-analysis and systematic reviews. Currently a professor in the Department of Health Services, Policy and Practice and co-director of the Center for Evidence-based Medicine at Brown University, Professor Lau has applied evidence-based methods to a variety of clinical, biomedical and healthcare topics; has developed reliable and efficient methods and tools to conduct systematic reviews and meta-analyses; and has advanced an understanding on the impact of factors that may contribute to differences of results in scientific studies. His past research includes cumulative meta-analysis of randomized controlled trials, comparison of results from large trials and meta-analyses of small trials, effect of baseline risk in the interpretation of clinical trial results, and empirical evaluation of existing methods of combining data. His current focus is on a Web-based repository of systematic review data, reviews of diagnostic tests, nutrition, clinical practice guidelines, and dissemination of evidence-based methods to varied health-care disciplines. This report is a conversation from an adapted version of an interview, more or less chronologically arranged, between Joseph C. Cappelleri as interviewer and Joseph Lau as interviewee, with Meghan Ingerick recording and transcribing the interview.

  6. Reactor

    DOEpatents

    Evans, Robert M.

    1976-10-05

    1. A neutronic reactor having a moderator, coolant tubes traversing the moderator from an inlet end to an outlet end, bodies of material fissionable by neutrons of thermal energy disposed within the coolant tubes, and means for circulating water through said coolant tubes characterized by the improved construction wherein the coolant tubes are constructed of aluminum having an outer diameter of 1.729 inches and a wall thickness of 0.059 inch, and the means for circulating a liquid coolant through the tubes includes a source of water at a pressure of approximately 350 pounds per square inch connected to the inlet end of the tubes, and said construction including a pressure reducing orifice disposed at the inlet ends of the tubes reducing the pressure of the water by approximately 150 pounds per square inch.

  7. 1. Historic American Buildings Survey Joseph Hill's Photograph Copy of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill's Photograph Copy of Original Photograph May5, 1936 SOUTH ELEVATION 1352 W.WASHINGTON BLVD. -1362 CHICAGO, ILLINOIS. - Chicago Ironwork, William M. Strong Estate (Cast Iron House & Gate), 1352 West Washington Boulevard, Chicago, Cook County, IL

  8. Joseph Kampé de Fériet et la mécanique des fluides en France durant l'entre-deux-guerres

    NASA Astrophysics Data System (ADS)

    Demuro, Antonietta

    2017-08-01

    Up until the twentieth century, fluid mechanics was characterised by a strong division between theory and practice. The formulas of mathematicians and physicists were difficult to apply experimentally and their relevance was neither well accepted nor well understood by engineers. In France, where priority was given to the theoretical aspects of this subject, the creation of several centres of fluid mechanics in the 1930s (Lille, Marseille, Paris and Toulouse) represented an attempt at a rapprochement between fluid mechanics, experimental aerodynamics, and hydrodynamics. The aim was to re-establish France's international profile, which had been lost after 1918. In Lille, the leadership of the ;Institut de mécanique des fluides; (IMFL) was entrusted to Jospeh Kampé de Fériet, who was able to address questions of both theoretical and experimental nature in the context of his work at the IMFL and at the ;Commission de la turbulence atmosphérique;. On the one hand, Kampé de Fériet used a probabilistic approach to give greater mathematical rigour to the statistical theory of turbulence due to Taylor-von Kármán. On the other hand, he played an active part in his group's experimental research on atmospheric turbulence. This paper aims to show in what way Kampé de Fériet's approach to fluid mechanics enabled him to contribute to the international development of the statistical theory of turbulence during the interwar period.

  9. Jay L. King, Joseph D. Huxman, and Orion D. Billeter Assist Pilot Milt Thompson into the M2-F2 Attac

    NASA Technical Reports Server (NTRS)

    1966-01-01

    NASA research pilot Milt Thompson is helped into the cockpit of the M2-F2 lifting body research aircraft at NASA's Flight Research Center (now the Dryden Flight Research Center). The M2-F2 is attached to a wing pylon under the wing of NASA's B-52 mothership. The flight was a captive flight with the pilot on-board. Milt Thompson flew in the lifting body throughout the flight, but it was never dropped from the mothership. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft

  10. Independent Verification of Research Reactor Operation (Analysis of the Georgian IRT-M Reactor by the Isotope Ratio Method)

    SciTech Connect

    Cliff, John B.; Frank, Douglas P.; Gerlach, David C.; Gesh, Christopher J.; Little, Winston W.; Reid, Bruce D.; Tsiklauri, Georgi V.; Abramidze, Sh; Rostomashvili, Z.; Kiknadze, G.; Dzhavakhishvily, O.; Nabakhtiani, G.

    2010-08-11

    The U.S. Department of Energy’s Office of Nonproliferation and International Security (NA-24) develops technologies to aid in implementing international nuclear safeguards. The Isotope Ratio Method (IRM) was successfully developed in 2005 – 2007 by Pacific Northwest National Laboratory (PNNL) and the Republic of Georgia’s Andronikashvili Institute of Physics as a generic technology to verify the declared operation of water-moderated research reactors, independent of spent fuel inventory. IRM estimates the energy produced over the operating lifetime of a fission reactor by measuring the ratios of the isotopes of trace impurity elements in non-fuel reactor components.The Isotope Ratio Method is a technique for estimating the energy produced over the operating lifetime of a fission reactor by measuring the ratios of the isotopes of impurity elements in non-fuel reactor components.

  11. Joseph Priestley and the Psychology of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Joseph Priestley, in his "A Course of Lectures on Oratory and Criticism," developed a psychological theory of style. The "Course" covers three main topics: traditional rhetorical arts of invention, arrangement, and style. Borrowing from the ideas of David Hartley, the association psychologist; Joseph Addison, the aesthetician;…

  12. Astronaut Joseph Kerwin strapped into sleep restraint in crew quarters

    NASA Image and Video Library

    1973-06-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity.

  13. Astronaut Joseph Kerwin strapped into sleep restraint in crew quarters

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, is photographed strapped into the sleep restraint in the crew quarters of the Orbital Workshop of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is wearing the special cap which contains biomedical instrumentation for the M133 Sleep Monitoring Experiment. The purpose of the M133 experiment is to evaluate quantity and quality of sleep during prolonged space flight by the analysis of electroencephalographic (EEG) and electrooculographic (EOG) activity.

  14. Joseph Maxwell on mediumistic personifications.

    PubMed

    Alvarado, Carlos S

    2016-09-01

    The study of mediumship received much impetus from the work of psychical researchers. This included ideas about the phenomena of personation, or changes in attitudes, dispositions and behaviours shown by some mediums that supposedly indicated discarnate action. The aim of this Classic Text is to reprint passages about this topic from the writings of French psychical researcher Joseph Maxwell (1858-1938), which were part of the contributions of some psychical researchers to reconceptualize the manifestations in psychological terms. Maxwell suggested these changes in mediums were a production of their subconscious mind. His ideas are a reflection of previous theorization about secondary personalities and a particular example of the contributions of psychical researchers to understand the psychology of mediumship.

  15. Improvement of 93mNb and 103mRh activity measurement methodology for reactor dosimetry

    NASA Astrophysics Data System (ADS)

    Riffaud, J.; Lépy, M.-C.; Domergue, C.; Philibert, H.; Destouches, C.; Thiollay, N.; Girard, J. M.

    2017-09-01

    Reactor dosimetry is based on the analysis of the activity of irradiated dosimeters, such as 93mNb and 103mRh. The activity measurement of these dosimeters is conventionally performed by X-ray spectrometry, but the low-energy of emitted photons makes it difficult to derive reliable results with low uncertainties. Approaches to improve these characterisations are presented: they include high accuracy efficiency calibration of a HPGe detector using both experiments and Monte Carlo simulation, calculation of corrective factors for the geometry (selfabsorption) and self-fluorescence effects. Improvement of the knowledge of the 103mRh decay scheme is also required and a specific experiment is proposed, including activity measurement of a 103mRh solution by liquid scintillation, and measurement of the photon emission intensities by X-ray spectrometry. A method for calculating coefficients to take into account the self-fluorescence effects in dosimeters is also suggested to improve the uncertainties on activity measurements.

  16. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  17. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  18. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  19. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  20. Joseph Priestley: Docter Phlogiston or Reverend Oxygen?

    PubMed

    Fara, Patricia

    2010-09-01

    In propaganda material, people are often presented in black-and-white terms as either a villain or a hero. Although Joseph Priestley is denigrated for believing in the discredited substance phlogiston, he is also celebrated for discovering oxygen.

  1. Application of cluster analysis and autoregressive neural networks for the noise diagnostics of the IBR-2M reactor

    NASA Astrophysics Data System (ADS)

    Pepelyshev, Yu. N.; Tsogtsaikhan, Ts.; Ososkov, G. A.

    2016-09-01

    The pattern recognition methodologies and artificial neural networks were used widely for the IBR-2M pulsed reactor noise diagnostics. The cluster analysis allows a detailed study of the structure and fast reactivity effects of IBR-2M and nonlinear autoregressive neural network (NAR) with local feedback connection allows predicting slow reactivity effects. In this work we present results of a study on pulse energy noise dynamics and prediction of liquid sodium flow rate through the core of the IBR-2M reactor using cluster analysis and an artificial neural network.

  2. Joseph Mayer and Statistical Mechanics

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    In the January 1937 issue of the Journal of Chemical Physics (Volume 5) there appeared a paper by Joseph Mayer which was the first of a series of articles. It produced great and immediate impact. The title was "The Statistical Mechanics of Condensing Systems. I," the abstract of this paper is given below: It is shown that for a system composed of N identical molecules with mutual potential energy, the assumption that the total potential energy can be expressed as the sum of that between pairs of molecules allows the derivation of simple, accurate formal equations for the thermodynamic properties of the system. Under certain conditions, generally fulfilled at low temperatures, the equations predict a region where the pressure and Gibb's free energy are independent of volume, the characteristic of condensing sytems. The equations permit calculation of the Gibb's free energy of the liquid in equilibrium with the vapor and all the properties of the saturated vapor, but not the volume or volume dependence of the condensed phase...

  3. Joseph Henry and the Telegraph

    NASA Astrophysics Data System (ADS)

    Hochfelder, David

    1997-04-01

    Morse's telegraph rested upon three scientific advances which occured between 1800 and 1830: the development of battery technology, the formulation of laws governing the behavior of electrical components in circuits, and the discovery of electromagnetic phenomena. Joseph Henry was crucial to the development of the early telegraph. His work on electromagnetism made it possible for the electric current to manifest itself as useful mechanical work. Henry developed electromagnets of sufficient lifting power, but which drew relatively small currents; these magnets were the heart of Morse's telegraph receiver. Morse also used electromagnets as relays, which allowed him to transmit signals over great distances. Morse often acknowledged his debt to Henry, and the two enjoyed a cordial working relationship until the mid-1840s. But during the bitter and protracted litigation over Morse's patent, Henry testified (unwillingly, he claimed) against the inventor. This began a lifelong quarrel between the two men, the specifics of which were tedious and petty. In general terms, however, their conflict arose over different notions regarding scientific discovery and technological innovation.

  4. High-density ultracold neutron sources for the WWR-M and PIK reactors

    SciTech Connect

    Serebrov, A. P. Fomin, A. K.; Kharitonov, A. G.; Lyamkin, V. A.; Prudnikov, D. V.; Ivanov, S. A.; Erykalov, A. N.; Onegin, M. S.; Gridnev, K. A.

    2016-01-15

    It is proposed to equip the PIK and WWR-M research reactors at the Petersburg Nuclear Physics Institute (PNPI) with high-density ultracold neutron (UCN) sources, where UCNs will be obtained based on the effect of their accumulation in superfluid helium (due to the specific features of this quantum fluid). The maximum UCN storage time in superfluid helium is obtained at temperatures on the order of 1 K. These sources are expected to yield UCN densities of 10{sup 3}–10{sup 4} cm{sup –3}, i.e., approximately three orders of magnitude higher than the density from existing UCN sources throughout the world. The development of highest intensity UCN sources will make PNPI an international center of fundamental UCN research.

  5. Rethinking Joseph Janangelo's "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts"

    ERIC Educational Resources Information Center

    College Composition and Communication, 2007

    2007-01-01

    This article presents several excerpts from an article written by Joseph Janangelo titled "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts." In his article, Janangelo suggested that Cornell's work and ideas about composing model intelligent ways to composing persuasive nonsequential text. Janangelo also wondered if the use of…

  6. Rethinking Joseph Janangelo's "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts"

    ERIC Educational Resources Information Center

    College Composition and Communication, 2007

    2007-01-01

    This article presents several excerpts from an article written by Joseph Janangelo titled "Joseph Cornell and the Artistry of Composing Persuasive Hypertexts." In his article, Janangelo suggested that Cornell's work and ideas about composing model intelligent ways to composing persuasive nonsequential text. Janangelo also wondered if the use of…

  7. Joseph Conrad's tormented Rescue (fantasy).

    PubMed

    Freedman, William

    2014-02-01

    Joseph Conrad was a notoriously tormented writer for whom the creative act was often a punishment severe enough to drive him into paralyzing depressions that delayed the completion of his novels, sometimes for years. By far the most agonizing of these projects was The Rescue, a novel he began in 1898, abandoned a year later, tried unsuccessfully to continue several times over the next two decades, but was only able to resume in 1918 and to complete, after another tortured two-year struggle, in 1920. An explanation for this incapacity, that is powerfully suggested by the novel's evocative title and perhaps unintentionally ironic subtitle (A Romance of the Shallows) has not yet been explored. Using Freud's 1910 essay on the rescue fantasy, "Contributions to the Psychology of Love: A Special Type of Choice of Object Made by Men," and Emanuel Berman's instructive revision and expansion of the concept in his 2003 American Imago essay, "Ferenczi, Rescue, and Utopia," I argue that a substantial explanation for Conrad's tormented history with The Rescue is ascribable to its quite remarkably faithful treatment of a rescue fantasy with deep and disabling resonance for its author. More specifically, the difficulty was compounded by the novel's dramatization of the soul-crushing conflict between two such fantasies: one in the service of the masculine ideal of unflinching dedication to a heroic purpose, the other promising satisfaction to the equally potent demands of emotional and sexual desire. Features of Conrad's narrative fit so tightly and consistently with the theory as Freud (and Abraham) proposed and as Berman elaborated it that The Rescue offers itself as one of those rare and reinforcing instances wherein the literary text seems to validate the psychoanalytic theory at least as persuasively as the theory "understands" the text.

  8. A 48-month extended fuel cycle for the B and W mPower{sup TM} small modular nuclear reactor

    SciTech Connect

    Erighin, M. A.

    2012-07-01

    The B and W mPower{sup TM} reactor is a small, rail-shippable pressurized water reactor (PWR) with an integral once-through steam generator and an electric power output of 150 MW, which is intended to replace aging fossil power plants of similar output. The core is composed of 69 reduced-height, but otherwise standard, PWR assemblies with the familiar 17 x 17 fuel rod array on a 21.5 cm inter-assembly pitch. The B and W mPower core design and cycle management plan, which were performed using the Studsvik core design code suite, follow the pattern of a typical nuclear reactor fuel cycle design and analysis performed by most nuclear fuel management organizations, such as fuel vendors and utilities. However, B and W is offering a core loading and cycle management plan for four years of continuous power operations without refueling and without the hurdles of chemical shim. (authors)

  9. Diversification of 99Mo/99mTc separation: non–fission reactor production of 99Mo as a strategy for enhancing 99mTc availability.

    PubMed

    Pillai, Maroor R A; Dash, Ashutosh; Knapp, Furn F Russ

    2015-01-01

    This paper discusses the benefits of obtaining (99m)Tc from non-fission reactor-produced low-specific-activity (99)Mo. This scenario is based on establishing a diversified chain of facilities for the distribution of (99m)Tc separated from reactor-produced (99)Mo by (n,γ) activation of natural or enriched Mo. Such facilities have expected lower investments than required for the proposed chain of cyclotrons for the production of (99m)Tc. Facilities can receive and process reactor-irradiated Mo targets then used for extraction of (99m)Tc over a period of 2 wk, with 3 extractions on the same day. Estimates suggest that a center receiving 1.85 TBq (50 Ci) of (99)Mo once every 4 d can provide 1.48-3.33 TBq (40-90 Ci) of (99m)Tc daily. This model can use research reactors operating in the United States to supply current (99)Mo needs by applying natural (nat)Mo targets. (99)Mo production capacity can be enhanced by using (98)Mo-enriched targets. The proposed model reduces the loss of (99)Mo by decay and avoids proliferation as well as waste management issues associated with fission-produced (99)Mo.

  10. 6. View northeast of Ten Acre Lot with Joseph Fry ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View northeast of Ten Acre Lot with Joseph Fry Farm complex (center) and Beehive House (right)in the background - Joseph Fry Farm Landscape, 2153 South County Trail Road (U.S. Route 2), East Greenwich, Kent County, RI

  11. Obituary: Richard Joseph Elston, 1960-2004

    NASA Astrophysics Data System (ADS)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  12. 75 FR 15430 - Chief Joseph Hatchery Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Chinook salmon and will help mitigate for the effects of the Federal Columbia River Power System on fish... Bonneville Power Administration Chief Joseph Hatchery Program AGENCY: Bonneville Power Administration (BPA....gov . FOR FURTHER INFORMATION, CONTACT: Mickey Carter, Bonneville Power Administration--KEC-4, P.O...

  13. Joseph Rotblat: Influences, Scientific Achievements and Legacy

    ERIC Educational Resources Information Center

    Underwood, Martin

    2008-01-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to…

  14. Joseph Rotblat: Influences, Scientific Achievements and Legacy

    ERIC Educational Resources Information Center

    Underwood, Martin

    2008-01-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to…

  15. Content, Joseph Schwab and German "Didaktik"

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This article attempts to extend and deepen the conversation concerning the knowledge-based approach to curriculum espoused by Michael Young in his 2013 "JCS" paper through revisiting the structure of the disciplines thinking of Joseph Schwab and German "Didaktik." It argues that curriculum making requires a theory of knowledge…

  16. Content, Joseph Schwab and German "Didaktik"

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This article attempts to extend and deepen the conversation concerning the knowledge-based approach to curriculum espoused by Michael Young in his 2013 "JCS" paper through revisiting the structure of the disciplines thinking of Joseph Schwab and German "Didaktik." It argues that curriculum making requires a theory of knowledge…

  17. An Interview with Joseph Chilton Pearce.

    ERIC Educational Resources Information Center

    Mercogliano, Chris

    1995-01-01

    Joseph Chilton Pearce, a writer who lectures internationally on child development, discusses the importance of the birth environment on infant development, the negative effects resulting from doctor-assisted births, his experiences in the births of his children, the importance of bonding, and the relationship between childbirth and childhood…

  18. An Interview with Joseph Chilton Pearce.

    ERIC Educational Resources Information Center

    Luvmour, Josette; Luvmour, Ba; Dupler-King, Kathy; Pearce, Joseph Chilton

    1999-01-01

    Author Joseph Chilton discusses parents' roles in child rearing, the importance of nurturing, and how negative and positive childhood experiences affect one's emotional and physical health throughout life. Describes neurocardiology, which is documenting the biological connections between the brain and heart and lifting the wisdom and intelligence…

  19. An Interview with Joseph Chilton Pearce.

    ERIC Educational Resources Information Center

    Luvmour, Josette; Luvmour, Ba; Dupler-King, Kathy; Pearce, Joseph Chilton

    1999-01-01

    Author Joseph Chilton discusses parents' roles in child rearing, the importance of nurturing, and how negative and positive childhood experiences affect one's emotional and physical health throughout life. Describes neurocardiology, which is documenting the biological connections between the brain and heart and lifting the wisdom and intelligence…

  20. An Interview with Joseph Chilton Pearce.

    ERIC Educational Resources Information Center

    Mercogliano, Chris

    1995-01-01

    Joseph Chilton Pearce, a writer who lectures internationally on child development, discusses the importance of the birth environment on infant development, the negative effects resulting from doctor-assisted births, his experiences in the births of his children, the importance of bonding, and the relationship between childbirth and childhood…

  1. DCEG Symposium to Honor Joseph F. Fraumeni, Jr. | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer On May 6, the Division of Cancer Epidemiology and Genetics (DCEG) will sponsor a symposium to honor 50 years of leadership from its founding director, Joseph F. Fraumeni, Jr., M.D., who stepped down from the position in July 2012. The conference, entitled “Cancer Epidemiology: From Pedigrees to Populations,” will highlight critical findings in cancer epidemiology from the last 50 years, as well as opportunities for future research directions. Long History of Leadership and Discovery

  2. DCEG Symposium to Honor Joseph F. Fraumeni, Jr. | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer On May 6, the Division of Cancer Epidemiology and Genetics (DCEG) will sponsor a symposium to honor 50 years of leadership from its founding director, Joseph F. Fraumeni, Jr., M.D., who stepped down from the position in July 2012. The conference, entitled “Cancer Epidemiology: From Pedigrees to Populations,” will highlight critical findings in cancer epidemiology from the last 50 years, as well as opportunities for future research directions. Long History of Leadership and Discovery

  3. Preliminary study of degradation from neutron effects of core-structural materials of Thai Research Reactor TRR-1/M1

    NASA Astrophysics Data System (ADS)

    Ampornrat, P.; Boonsuwan, P.; Sangkaew, S.; Angwongtrakool, T.

    2017-06-01

    Thai research reactor went first critical in 1962. The reactor was converted in 1977 from an MTR-type with high-enriched uranium fuel to a TRIGA-MARK III type using low-enriched uranium fuel, called TRR-1/M1. Since the TRR-1/M1 has been operated for almost 40 years, degradation of reactor structural materials is expected. In this preliminary study, the potential degradation from neutron effects of core-structural materials, e.g., fuel clad (SS304) and core components (Al6061) were studied. Assessment included calculation of neutron energy, flux and fluence in the reactor core to evaluate displacement rate (dpa) and irradiation effects on the material properties. Results showed maximum displacement rates on SS304 was 5.24×10-8 per cm3·sec and on Al6061 was 1.14×10-8 per cm3·sec. The corresponding maximum displacement levels were ∼17 dpa for SS304, and ∼4 dpa for Al6061. At these levels of displacement, it is possible for the materials to result in tensile strength increasing and ductility reduction. Further inspection on the core-structural materials needs to be conducted to validate the assessment results from this study.

  4. Reactor performance of a 750 m(3) anaerobic digestion plant: varied substrate input conditions impacting methanogenic community.

    PubMed

    Wagner, Andreas Otto; Malin, Cornelia; Lins, Philipp; Gstraunthaler, Gudrun; Illmer, Paul

    2014-10-01

    A 750 m(3) anaerobic digester was studied over a half year period including a shift from good reactor performance to a reduced one. Various abiotic parameters like volatile fatty acids (VFA) (formic-, acetic-, propionic-, (iso-)butyric-, (iso-)valeric-, lactic acid), total C, total N, NH4 -N, and total proteins, as well as the organic matter content and dry mass were determined. In addition several process parameters such as temperature, pH, retention time and input of substrate and the concentrations of CH4, H2, CO2 and H2S within the reactor were monitored continuously. The present study aimed at the investigation of the abundance of acetogens and total cell numbers and the microbial methanogenic community as derived from PCR-dHPLC analysis in order to put it into context with the determined abiotic parameters. An influence of substrate quantity on the efficiency of the anaerobic digestion process was found as well as a shift from a hydrogenotrophic in times of good reactor performance towards an acetoclastic dominated methanogenic community in times of reduced reactor performance. After the change in substrate conditions it took the methano-archaeal community about 5-6 weeks to be affected but then changes occurred quickly.

  5. Extension of RAPTOR-M3G to r-θ-z Geometry for Use in Reactor Dosimetry Applications

    NASA Astrophysics Data System (ADS)

    Hunter, Melissa A.; Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3-D Geometries) is a new deterministic radiation transport code that was originally developed for x-y-z geometry. The development of the r-θ-z version of RAPTOR-M3G and its application to determine ex-vessel neutron dosimetry responses in the cavity of a typical 2-loop pressurized water reactor is presented. The neutron dosimetry responses determined from RAPTOR-M3G and TORT 3-D r-θ-z calculations are compared to actual measured responses.

  6. The first critical experiment with a LEU Russian fuel IRT-4M at the training reactor VR-1

    SciTech Connect

    Frybort, Jan

    2008-07-15

    A critical experiment is a standard part of training of students at the Training Reactor VR-1 operated within the Faculty of Nuclear Sciences and Physical Engineering at the Czech Technical University in Prague. In autumn 2005 the HEU fuel IRT-3M with enrichment 36 % {sup 235}U was replaced by the LEU fuel IRT-4M with enrichment 19.7 % {sup 235}U. The fuel replacement at the VR-1 Reactor is a part of an international program RERTR. This Paper presents basic information about preparation for the fuel replacement and approaching of the first critical state with the new zone configuration C1 which replaced B1 core with the old IRT-3M fuel. The whole process was carried out according to the Czech law and the relevant international recommendations. The experience with the VR-1 operation confirms the assumption that the C1 core configuration will be suitable from the point of view of the reactivity balance for the long term safe operation of the Training Reactor VR-1. (author)

  7. An extended conventional fuel cycle for the B and W mPower{sup TM} small modular nuclear reactor

    SciTech Connect

    Scarangella, M. J.

    2012-07-01

    The B and W mPower{sup TM} reactor is a small pressurized water reactor (PWR) with an integral once-through steam generator and a thermal output of about 500 MW; it is intended to replace aging fossil power plants of similar output. The core is composed of 69 reduced-height PWR assemblies with the familiar 17 x 17 fuel rod array. The Babcock and Wilcox Company (B and W) is offering a core loading and cycle management plan for a four-year cycle based on its presumed attractiveness to potential customers. This option is a once-through fuel cycle in which the entire core is discharged and replaced after four years. In addition, a conventional fuel utilization strategy, employing a periodic partial reload and shuffle, was developed as an alternative to the four-year once-through fuel cycle. This study, which was performed using the Studsvik core design code suite, is a typical multi-cycle projection analysis of the type performed by most fuel management organizations such as fuel vendors and utilities. In the industry, the results of such projections are used by the financial arms of these organizations to assist in making long-term decisions. In the case of the B and W mPower reactor, this analysis demonstrates flexibility for customers who consider the once-through fuel cycle unacceptable from a fuel utilization standpoint. As expected, when compared to the once-through concept, reloads of the B and W mPower reactor will achieve higher batch average discharge exposure, will have adequate shut-down margin, and will have a relatively flat hot excess reactivity trend at the expense of slightly increased peaking. (authors)

  8. Operating characteristic analysis of a 400 mH class HTS DC reactor in connection with a laboratory scale LCC type HVDC system

    NASA Astrophysics Data System (ADS)

    Kim, Sung-Kyu; Kim, Kwangmin; Park, Minwon; Yu, In-Keun; Lee, Sangjin

    2015-11-01

    High temperature superconducting (HTS) devices are being developed due to their advantages. Most line commutated converter based high voltage direct current (HVDC) transmission systems for long-distance transmission require large inductance of DC reactor; however, generally, copper-based reactors cause a lot of electrical losses during the system operation. This is driving researchers to develop a new type of DC reactor using HTS wire. The authors have developed a 400 mH class HTS DC reactor and a laboratory scale test-bed for line-commutated converter type HVDC system and applied the HTS DC reactor to the HVDC system to investigate their operating characteristics. The 400 mH class HTS DC reactor is designed using a toroid type magnet. The HVDC system is designed in the form of a mono-pole system with thyristor-based 12-pulse power converters. In this paper, the investigation results of the HTS DC reactor in connection with the HVDC system are described. The operating characteristics of the HTS DC reactor are analyzed under various operating conditions of the system. Through the results, applicability of an HTS DC reactor in an HVDC system is discussed in detail.

  9. Sleep disorders in Machado-Joseph disease.

    PubMed

    Pedroso, José Luiz; Braga-Neto, Pedro; Martinez, Alberto R M; Martins, Carlos R; Rezende Filho, Flávio M; Sobreira-Neto, Manoel A; Prado, Lucila B F; do Prado, Gilmar F; França, Marcondes C; Barsottini, Orlando G P

    2016-11-01

    This article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD). Pathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders. Sleep disorders are frequent in MJD, and include restless legs syndrome, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, insomnia, sleep apnea, periodic limb movements during sleep, parasomnia, and others. Pathophysiological mechanisms related to sleep disorders in Machado-Joseph are complex and poorly understood. Considering that sleep complaints are a treatable condition, recognizing sleep disorders in MJD is relevant.

  10. [Chemistry dictionary of Pierre-Joseph Macquer].

    PubMed

    Viel, Claude

    2004-01-01

    In 1976, Pierre-Joseph Macquer publishes the first edition of his Chemistry dictionary, the first concerning this science. A second edition with many additions has been printed in 1778, bearing in mind the new concepts borned with the chemistry evolution. All chemists are unanimous to salute this monumental and precious work. These different aspects are presented in this Note, near the examination of the exemplary of this dictionary annotated by Jean Hermann, alsatian doctor and naturalist contemporary of Macquer.

  11. A CFD M&S PROCESS FOR FAST REACTOR FUEL ASSEMBLIES

    SciTech Connect

    Kurt D. Hamman; Ray A. Berry

    2008-09-01

    A CFD modeling and simulation process for large-scale problems using an arbitrary fast reactor fuel assembly design was evaluated. Three dimensional flow distributions of sodium for several fast reactor fuel assembly pin spacing configurations were simulated on high performance computers using commercial CFD software. This research focused on 19-pin fuel assembly “benchmark” geometry, similar in design to the Advanced Burner Test Reactor, where each pin is separated by helical wire-wrap spacers. Several two-equation turbulence models including the k-e and SST (Menter) k-? were evaluated. Considerable effort was taken to resolve the momentum boundary layer, so as to eliminate the need for wall functions and reduce computational uncertainty. High performance computers were required to generate the hybrid meshes needed to predict secondary flows created by the wire-wrap spacers; computational meshes ranging from 65 to 85 million elements were common. A general validation methodology was followed, including mesh refinement and comparison of numerical results with empirical correlations. Predictions for velocity, temperature, and pressure distribution are shown. The uncertainty of numerical models, importance of high fidelity experimental data, and the challenges associated with simulating and validating large production-type problems are presented.

  12. Thermal-Hydraulic Simulations of Single Pin and Assembly Sector for IVG- 1M Reactor

    SciTech Connect

    Kraus, A.; Garner, P.; Hanan, N.

    2015-01-15

    Thermal-hydraulic simulations have been performed using computational fluid dynamics (CFD) for the highly-enriched uranium (HEU) design of the IVG.1M reactor at the Institute of Atomic Energy (IAE) at the National Nuclear Center (NNC) in the Republic of Kazakhstan. Steady-state simulations were performed for both types of fuel assembly (FA), i.e. the FA in rows 1 & 2 and the FA in row 3, as well as for single pins in those FA (600 mm and 800 mm pins). Both single pin calculations and bundle sectors have been simulated for the most conservative operating conditions corresponding to the 10 MW output power, which corresponds to a pin unit cell Reynolds number of only about 7500. Simulations were performed using the commercial code STAR-CCM+ for the actual twisted pin geometry as well as a straight-pin approximation. Various Reynolds-Averaged Navier-Stokes (RANS) turbulence models gave different results, and so some validation runs with a higher-fidelity Large Eddy Simulation (LES) code were performed given the lack of experimental data. These singled out the Realizable Two-Layer k-ε as the most accurate turbulence model for estimating surface temperature. Single-pin results for the twisted case, based on the average flow rate per pin and peak pin power, were conservative for peak clad surface temperature compared to the bundle results. Also the straight-pin calculations were conservative as compared to the twisted pin simulations, as expected, but the single-pin straight case was not always conservative with regard to the straight-pin bundle. This was due to the straight-pin temperature distribution being strongly influenced by the pin orientation, particularly near the outer boundary. The straight-pin case also predicted the peak temperature to be in a different location than the twisted-pin case. This is a limitation of the straight-pin approach. The peak temperature pin was in a different location from the peak power pin in every case simulated, and occurred at an

  13. Anaerobic methanethiol degradation in upflow anaerobic sludge bed reactors at high salinity (> or =0.5 M Na(+)).

    PubMed

    van Leerdam, Robin C; de Bok, Frank A M; Lens, Piet N L; Stams, Alfons J M; Janssen, Albert J H

    2007-09-01

    The feasibility of anaerobic methanethiol (MT) degradation at elevated sodium concentrations was investigated in a mesophilic (30 degrees C) lab-scale upflow anaerobic sludge bed (UASB) reactor, inoculated with estuarine sediment originating from the Wadden Sea (The Netherlands). MT was almost completely degraded (>95%) to sulfide, methane and carbon dioxide at volumetric loading rates up to 37 mmol MT x L(-1) x day(-1), 0.5 M sodium (NaCl or NaHCO(3)) and between pH 7.3 and 8.4. Batch experiments revealed that inhibition of MT degradation started at sodium (both NaCl and NaHCO(3)) concentrations exceeding 0.8 M. Sulfide inhibited MT degradation already around 3 mM (pH 8.3).

  14. Astronaut Joseph Kerwin test subject Lower Body Negative Pressure experiment

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, serves as test subject for the Lower Body Negative Pressure Experiment. Astronaut Paul J. Weitz, Skylab 2 pilot, assists Kerwin with the blood pressure cuff. They are in the experiment and work area of the Orbital Workshop crew quarters of the Skylab 1 and 2 space station cluster in Earth orbit. Kerwin is lying in the lower body negative pressure device. The purpose of the M092 experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide inflight data for predicting the degree of orthostatic intolerance and impairment of physical capacity to be expected upon return to Earth environment. The data collected in support of M092 are blood pressure, heart rate, body temperature, vectorcardiogram, LBNPD pressure, leg volume changes, and body weight.

  15. 1. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. VIEW FROM SOUTH-EAST - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL

  16. 2. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. VIEW FROM NORTH-WEST - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL

  17. 3. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. SOUTH ELEVATION (FRONT) - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL

  18. Experiment on search for neutron–antineutron oscillations using a projected UCN source at the WWR-M reactor

    NASA Astrophysics Data System (ADS)

    Fomin, A. K.; Serebrov, A. P.; Zherebtsov, O. M.; Leonova, E. N.; Chaikovskii, M. E.

    2017-01-01

    We propose an experiment on search for neutron–antineutron oscillations based on the storage of ultracold neutrons (UCN) in a material trap. The sensitivity of the experiment mostly depends on the trap size and the amount of UCN in it. In Petersburg Nuclear Physics Institute (PNPI) a high-intensity UCN source is projected at the WWR-M reactor, which must provide UCN density 2-3 orders of magnitude higher than existing sources. The results of simulations of the designed experimental scheme show that the sensitivity can be increased by ∼ 10–40 times compared to sensitivity of previous experiment depending on the model of neutron reflection from walls.

  19. [Joseph Babinski's contribution to neurological symptomatology].

    PubMed

    Furukawa, Tetsuo

    2014-11-01

    Joseph Babinski (1857-1932) was an excellent clinician. André Breton, a French poet, described Babinski's way of clinical examination in his Manifeste du surréalisme (1924), which vividly revealed Babinski's meticulous character. Babinski is well known by his eponymous Babinski reflex. Although some predecessors had described this phenomenon briefly, its meaning was interpreted by Babinski. His contribution to neurological symptomatology was not restricted to his plantar skin reflex, but also to other wide area. In this article, symptoms described by Babinski, i.e. plantar skin reflex, cerebellar symptoms including cerebellar asynergy, adiadochokinesis, dysmetria, cerebellar catalepsy, and rising sign, platysma sign, anosognosia are explained and are critically discussed.

  20. [Joseph Rollet & the shadow of Ricord].

    PubMed

    Chevallier, Jacques

    2010-01-01

    There are three distinguished names in French venereology during the first half of XIXth century: Ricord, Bassereau and Rollet. Ricord is above all a colourful practitioner of fashionable circles and he takes care of a lot of VIP: political people, actors, writers ... With his influence he takes strong opinions but in fact he has only linked gonorrhoea with veneral ulcers. Joseph Rollet head surgeon in the Antiquaille hospital of Lyon, continuing the studies of Bassereau, proves many basic points about venereal diseases often opposed to the theories of Ricord. So theses two scientists too discret or provincial will remain in the shadow of Ricord.

  1. Selection and identification of a bacterial community able to degrade and detoxify m-nitrophenol in continuous biofilm reactors.

    PubMed

    González, Ana J; Fortunato, María S; Papalia, Mariana; Radice, Marcela; Gutkind, Gabriel; Magdaleno, Anahí; Gallego, Alfredo; Korol, Sonia E

    2015-12-01

    Nitroaromatics are widely used for industrial purposes and constitute a group of compounds of environmental concern because of their persistence and toxic properties. Biological processes used for decontamination of nitroaromatic-polluted sources have then attracted worldwide attention. In the present investigation m-nitrophenol (MNP) biodegradation was studied in batch and continuous reactors. A bacterial community able to degrade the compound was first selected from a polluted freshwater stream and the isolates were identified by the analysis of the 16S rRNA gene sequence. The bacterial community was then used in biodegradation assays. Batch experiments were conducted in a 2L aerobic microfermentor at 28 °C and with agitation (200 rpm). The influence of abiotic factors in the biodegradation process in batch reactors, such as initial concentration of the compound and initial pH of the medium, was also studied. Continuous degradation of MNP was performed in an aerobic up-flow fixed-bed biofilm reactor. The biodegradation process was evaluated by determining MNP and ammonium concentrations and chemical oxygen demand (COD). Detoxification was assessed by Vibrio fischeri and Pseudokirchneriella subcapitata toxicity tests. Under batch conditions the bacterial community was able to degrade 0.72 mM of MNP in 32 h, with efficiencies higher than 99.9% and 89.0% of MNP and COD removals respectively and with concomitant release of ammonium. When the initial MNP concentration increased to 1.08 and 1.44 mM MNP the biodegradation process was accomplished in 40 and 44 h, respectively. No biodegradation of the compound was observed at higher concentrations. The community was also able to degrade 0.72 mM of the compound at pH 5, 7 and 9. In the continuous process biodegradation efficiency reached 99.5% and 96.8% of MNP and COD removal respectively. The maximum MNP removal rate was 37.9 gm(-3) day(-1). Toxicity was not detected after the biodegradation process.

  2. Criticality calculations for the VR-1 reactor with IRT-3M-HEU fuel and IRT-4MLEU fuel.

    SciTech Connect

    Hanan, N. A.; Matos, J. E.

    2007-01-17

    At The request of the Czech Technical University in Prague, ANL has performed independent verification calculations using the MCNP Monte Carlo code for three core configurations of the VR-1 reactor: a current core configuration B1 with HEU (36%) IRT-3M fuel assemblies and planned core configurations C1 and C2 with LEU (19.7%) IRT-4M fuel assemblies. Details of these configurations were provided to ANL by CTU. For core configuration B1, criticality calculations were performed for two sets of control rod positions provided to ANL by CTU. For core configurations C1 and C2, criticality calculations were done for cases with all control rods at the top positions, all control rods at the bottom positions, and two critical states of the reactor for different control rod positions. In addition, sensitivity studies for variation of the {sup 235}U mass in each fuel assembly and variation of the fuel meat and cladding thicknesses in each of the fuel tubes were done for the C1 core configuration. Finally the reactivity worth of the individual control rods was calculated for the B1, C1, and C2 core configurations.

  3. Jacques Joseph: Father of modern aesthetic surgery

    PubMed Central

    Bhattacharya, Surajit

    2008-01-01

    When we review the history of modern aesthetic surgery, a name that stands out as bright as a beacon and precious as gold is undoubtedly that of Jacques Joseph. A surgeon, par excellence, far ahead of his time, who chose to think out of the box, Joseph, despite all odds set out to give respectability to Aesthetic Surgery without depriving it of any scientific core values. By his words and deeds proved beyond doubt that only the very best in the field of reconstructive surgery, can visualize the hidden perfection in imperfection and formulate a treatment plan and a surgical strategy to achieve that elusive perfection. The rich surgical literature that he has left behind, the wealth of surgical instruments that he had designed and above all a way of thinking that he propagated, that aesthetic surgery is not frivolous but very serious endeavor, and treating the psychology of the patient is as important as treating his disease, undoubtedly makes him the revered ‘Father of Modern Aesthetic Surgery’. PMID:20174541

  4. Interview--Cliff Joseph: Art Therapist, Pioneer, Artist.

    ERIC Educational Resources Information Center

    Riley-Hiscox, Anna

    1997-01-01

    Interview of Cliff Joseph, one of the first African Americans to participate in the American Art Therapy Association and to become a registered art therapist and teacher. Details Joseph's impact on art therapy and cultural and social issues, as well as his relationships with other prominent art therapists. (MKA)

  5. Tribes of Men: John Joseph Mathews and Indian Internationalism

    ERIC Educational Resources Information Center

    Lutenski, Emily

    2012-01-01

    In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

  6. Tribes of Men: John Joseph Mathews and Indian Internationalism

    ERIC Educational Resources Information Center

    Lutenski, Emily

    2012-01-01

    In this article, the author discusses John Joseph Mathews and Indian internationalism. As an old man, Osage intellectual, writer, and historian, John Joseph Mathews recalled his expatriation from the United States during the 1920s. After growing up in Pawhuska, Oklahoma, seat of the Osage Nation, where he had been born in 1894 to a white mother…

  7. Prototypic Enhanced Risk Monitor Framework and Evaluation - Advanced Reactor Technology Milestone: M3AT-15PN2301054

    SciTech Connect

    Ramuhalli, Pradeep; Hirt, Evelyn H.; Veeramany, Arun; Bonebrake, Christopher A.; Ivans, William J.; Coles, Garill A.; Coble, Jamie B.; Liu, X.; Wootan, David W.; Mitchell, Mark R.; Brass, Mary F.

    2015-09-24

    This research report summaries the development and evaluation of a prototypic enhanced risk monitor (ERM) methodology (framework) that includes alternative risk metrics and uncertainty analysis. This updated ERM methodology accounts for uncertainty in the equipment condition assessment (ECA), the prognostic result, and the probabilistic risk assessment (PRA) model. It is anticipated that the ability to characterize uncertainty in the estimated risk and update the risk estimates in real time based on equipment condition assessment (ECA) will provide a mechanism for optimizing plant performance while staying within specified safety margins. These results (based on impacting active component O&M using real-time equipment condition information) are a step towards ERMs that, if integrated with AR supervisory plant control systems, can help control O&M costs and improve affordability of advanced reactors.

  8. Integral cross section measurement of the U 235 ( n , n ' ) U 235 m reaction in a pulsed reactor

    DOE PAGES

    Bélier, G.; Bond, E. M.; Vieira, D. J.; ...

    2015-04-08

    The integral measurement of the neutron inelastic cross section leading to the 26-minute half-life 235mU isomer in a fission-like neutron spectrum is presented. The experiment has been performed at a pulsed reactor, where the internal conversion decay of the isomer was measured using a dedicated electron detector after activation. The sample preparation, efficiency measurement, irradiation, radiochemistry purification, and isomer decay measurement will be presented. We determined the integral cross section for the ²³⁵U(n,n')235mU reaction to be 1.00±0.13b. This result supports an evaluation performed with TALYS-1.4 code with respect to the isomer excitation as well as the total neutron inelastic scatteringmore » cross section.« less

  9. Application programming interface document for the modernized Transient Reactor Analysis Code (TRAC-M)

    SciTech Connect

    Mahaffy, J.; Boyack, B.E.; Steinke, R.G.

    1998-05-01

    The objective of this document is to ease the task of adding new system components to the Transient Reactor Analysis Code (TRAC) or altering old ones. Sufficient information is provided to permit replacement or modification of physical models and correlations. Within TRAC, information is passed at two levels. At the upper level, information is passed by system-wide and component-specific data modules at and above the level of component subroutines. At the lower level, information is passed through a combination of module-based data structures and argument lists. This document describes the basic mechanics involved in the flow of information within the code. The discussion of interfaces in the body of this document has been kept to a general level to highlight key considerations. The appendices cover instructions for obtaining a detailed list of variables used to communicate in each subprogram, definitions and locations of key variables, and proposed improvements to intercomponent interfaces that are not available in the first level of code modernization.

  10. Joseph F. Poland (1908-1991)

    NASA Astrophysics Data System (ADS)

    Johnson, A. Ivan

    On June 4, 1991, AGU Fellow Joseph Fairfield Poland died in a Sacramento, Calif., hospital at the age of 83 after a long fight with Parkinson's Disease. A recognized expert on land subsidence and a retiree from the U.S. Geological Survey's Water Resources Division, his death occurred only 2 weeks after the end of the 4th International Symposium on Land Subsidence, held in Houston, Tex. Frequently known as “Mr. Land Subsidence,” it was appropriate that the proceedings of that symposium had been dedicated to him.Born in Boston, Poland earned a bachelor's degree in geology from Harvard University in 1929. He was resident geologist for Tropical Oil Company in Colombia from 1929 to 1931. After returning to the United States, Poland earned his master's degree in geology from Stanford University in 1935, taught groundwater hydrology, and consulted on groundwater and geophysical problems in the West and Southwest.

  11. Joseph Boussinesq's legacy in fluid mechanics

    NASA Astrophysics Data System (ADS)

    Darrigol, Olivier

    2017-07-01

    Joseph Boussinesq was the most prolific of all French contributors to nineteenth-century fluid mechanics. His scientific production included a novel theory of solitary waves, the KdV equation for finite deformations of the water surface in an open channel, a systematic study of open channel and pipe flow based on the concept of effective viscosity, pioneering derivations of boundary layers and entrance effects, new exact solutions of the Navier-Stokes equation under geometrically simple boundary conditions, and the 'Boussinesq approximation' for heat convection in a moving fluid under gravity. Although his extraordinary skills were quickly recognized and rewarded, other experts in the field were often unaware even of his most important results and they ended up rediscovering some of them. Boussinesq's unusual background and the resulting peculiarities of his style explain this problematic diffusion. They also account for the richness of his legacy.

  12. The energy release and temperature field in the ultracold neutron source of the WWR-M reactor at the Petersburg Nuclear Physics Institute

    NASA Astrophysics Data System (ADS)

    Serebrov, A. P.; Kislitsin, B. V.; Onegin, M. S.; Lyamkin, V. A.; Prudnikov, D. V.; Ilatovskiy, V. A.; Orlov, S. P.; Kirsanov, G. A.; Fomin, A. K.; Filchenkova, D. V.

    2016-12-01

    Results of calculations of energy releases and temperature fields in the ultracold neutron source under design at the WWR-M reactor are presented. It is shown that, with the reactor power of 18 MW, the power of energy release in the 40-L volume of the source with superfluid helium will amount to 28.5 W, while 356 W will be released in a liquid-deuterium premoderator. The lead shield between the reactor core and the source reduces the radiative heat release by an order of magnitude. A thermal power of 22 kW is released in it, which is removed by passage of water. The distribution of temperatures in all components of the vacuum structure is presented, and the temperature does not exceed 100°C at full reactor power. The calculations performed make it possible to go to design of the source.

  13. The energy release and temperature field in the ultracold neutron source of the WWR-M reactor at the Petersburg Nuclear Physics Institute

    SciTech Connect

    Serebrov, A. P. Kislitsin, B. V.; Onegin, M. S.; Lyamkin, V. A.; Prudnikov, D. V.; Ilatovskiy, V. A.; Orlov, S. P.; Kirsanov, G. A.; Fomin, A. K.; Filchenkova, D. V.

    2016-12-15

    Results of calculations of energy releases and temperature fields in the ultracold neutron source under design at the WWR-M reactor are presented. It is shown that, with the reactor power of 18 MW, the power of energy release in the 40-L volume of the source with superfluid helium will amount to 28.5 W, while 356 W will be released in a liquid-deuterium premoderator. The lead shield between the reactor core and the source reduces the radiative heat release by an order of magnitude. A thermal power of 22 kW is released in it, which is removed by passage of water. The distribution of temperatures in all components of the vacuum structure is presented, and the temperature does not exceed 100°C at full reactor power. The calculations performed make it possible to go to design of the source.

  14. Respirometric response and microbial succession of nitrifying sludge to m-cresol pulses in a sequencing batch reactor.

    PubMed

    Ordaz, Alberto; Sánchez, Mariana; Rivera, Rodrigo; Rojas, Rafael; Zepeda, Alejandro

    2017-02-01

    A nitrifying consortium was kinetically, stoichiometrically and molecularly characterized via the in situ pulse respirometric method and pyrosequencing analysis before and after the addition of m-cresol (25 mg C L(-1)) in a sequencing batch reactor (SBR). Five important kinetic and stoichiometric parameters were determined: the maximum oxygen uptake rate, the maximum nitrification rate, the oxidation yield, the biomass growth yield, and the substrate affinity constant. An inhibitory effect was observed in the nitrification process with a recovery of this by up to eight SBR cycles after m-cresol was added to the system. However, full recovery of the nitrification process was not observed, as the maximum oxygen uptake rate was 25% lower than that of the previous operation without m-cresol addition. Furthermore, the pyrosequencing analyses of the nitrifying consortium after the addition of only two pulses of 25 mg C L(-1) m-cresol showed an important microbial community change represented by a decrease in the nitrifying populations and an increase in the populations degrading phenolic compounds.

  15. Simulation of plasma chemistry in a modified Gaseous Electronics Conference (mGEC) research reactor

    NASA Astrophysics Data System (ADS)

    Sant, Sanket; Joseph, E. A.; Liu, Yonghua; Overzet, L. J.; Zhou, Bao; Goeckner, M. J.

    2002-10-01

    In this paper, we make use of the Hybrid Plasma Equipment Model (HPEM) [1] and Langmuir probes to examine the mGEC. The mGEC was designed to study the interactions of the radicals created in a high density low pressure plasma with the chamber walls. The tool has the ability to change its geometrical structure in various dimensions, allowing us to closely inspect various plasma-wall interactions. This ability can be imperative in deciding the exact wall conditions necessary for optimal yield in a real time process. This paper presents a part of this project by matching Langmuir probe results taken in the mGEC cell when a highly polymerizing gas, CF4, is used to create a high density low pressure plasma. The results are compared to the theoretical results derived from modeling the chamber conditions using the Hybrid plasma equipment model (HPEM). [1] R. Kinder and M.J. Kushner, 'Non-Collisional Heating and Electron Energy Distributions in Magnetically Enhanced Inductively Coupled and Helicon Plasma Sources', J. Appl. Phys. 90, 3699 (2001). This work is supported by a grant from NSF / DOE, CTS-0078669.

  16. 1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 STAIR RAILING, 66 WEST OAK STREET - Chicago Ironwork, 66 West Oak Street (Cast Iron Stair Railing), 66 West Oak Street, Chicago, Cook County, IL

  17. 20. Photocopy of photograph (from Joseph R. Knowland Collection, Oakland, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photocopy of photograph (from Joseph R. Knowland Collection, Oakland, California, c. 1902) EXTERIOR, DETAIL OF BELFRY & CONVENTO, OVERGROWN CONDITIONS, C. 1902 - Mission San Francisco Solano de Sonoma, First & Spain Streets, Sonoma, Sonoma County, CA

  18. 1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH LOANED BY THE COMMANDANT, EARLY PHOTO OF HOUSE DATE UNKNOWN. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  19. 1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 COPIED FROM AN OLD PHOTOGRAPH LOANED BY MRS. NELLY MUNRO - Old Baptist Parsonage, Snyder & Virginia Streets, Sublette, Lee County, IL

  20. 1. Historic American Buildings Survey Copied by Joseph Hill from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Copied by Joseph Hill from an old photograph loaned by Alice Snyder, Galena, Illinois. SOUTH EAST ELEVATION - Grace Episcopal Church, South Prospect Street, Galena, Jo Daviess County, IL

  1. 2. Historic American Buildings Survey Copied by Joseph Hill from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Copied by Joseph Hill from photograph loaned by the Illinois Bell Telephone Co. SOUTH EAST ELEVATION - Grace Episcopal Church, South Prospect Street, Galena, Jo Daviess County, IL

  2. 2. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF AN OLD PHOTOGRAPH LOANED BY THE COMMANDANT, ARSENAL ISLAND 1870 - Rock Island Arsenal, Rock Island, Rock Island County, IL

  3. 1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF PHOTOGRAPH LOANED BY THE COMMANDANT, FORT ARMSTRONG 1819 FROM A MODEL IN ARSENAL MUSEUM - Fort Armstrong, Rock Island, Rock Island County, IL

  4. 19. Historic American Buildings Survey Joseph Hill, Photographer COL. DAVENPORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Historic American Buildings Survey Joseph Hill, Photographer COL. DAVENPORT Copy of an old photograph loaned by the commandant. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  5. 4. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH LOANED BY THE COMMANDANT, FORT ARMSTRONG ARSENAL ISLAND 1819 - Fort Armstrong, Rock Island, Rock Island County, IL

  6. 5. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF OLD PHOTOGRAPH LOANED BY THE COMMANDANT. DATE UNKNOWN - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  7. 1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer May 1936 COPY OF AN OLD PHOTOGRAPH LOANED BY THE COMMANDANT, EARLY BRIDGE ACROSS MISSISSIPPI RIVER, DATE UNKNOWN. - Bridge Spanning Mississippi River, Rock Island, Rock Island County, IL

  8. 1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer October 1936 #12 EARLY RED BRICK HOUSE, Elk and Prospect Sts., Galena, Illinois - Galena Doorways, Red Brick House, Elk & Prospect Streets, Galena, Jo Daviess County, IL

  9. 2. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Joseph Hill, Photographer July 1936 BALCONY RAILING, 945 NO. DEARBORN ST. JUDGE CARPENTER'S HOME - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  10. 3. Historic American Buildings Survey Joseph Hill, Photographer June, 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Joseph Hill, Photographer June, 1936 DETAIL OF BALCONY RAILING, 945 NO. DEARBORN ST. JUDGE CARPENTER'S HOME - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  11. 12. Historic American Buildings Survey Joseph Hill, Photographer July 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Joseph Hill, Photographer July 10, 1936 SOUTH ELEVATION (Copied from student's drawing, Dept. of Architecture, Armour Institute of Technology. Chicago) - Keating House, U.S. Highway 430, Fayville, Alexander County, IL

  12. 18. Historic American Buildings Survey Joseph Hill, Photographer May 26, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Historic American Buildings Survey Joseph Hill, Photographer May 26, 1936 FIREPLACE IN DINING ROOM, The Davenport House, Rock Island Arsenal - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  13. 3. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Joseph Hill, Photographer August 1936 BRONZE TABLET HISTORICAL MARKER - Hobson Grist Mill (Monument & Millstones), DuPage County Pioneer Park, Naperville, Du Page County, IL

  14. 7. Detail of balcony rail. August 1936. Joseph Hill, photographer, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail of balcony rail. August 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  15. 1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 1936 FIRST ORIGINAL STORE AND POSTOFFICE, COPY OF AN EARLY PHOTOGRAPH. LENT BY EVELYN S. CRAIG - Jansonist Colony, Colony Store & Post Office, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  16. 6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Detail of pilaster cap. Aug. 10, 1936. Joseph Hill, photographer, copied from small photo taken by survey member. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  17. 3. West and south elevations. Joseph Hill, photographer, copied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West and south elevations. Joseph Hill, photographer, copied from photo lent by Evelyn S. Craig. August 1936. - Jansonist Colony, Steeple Building, Main & Bishop Hill Streets, Bishop Hill, Henry County, IL

  18. 12. Historic American Buildings Survey Joseph Hill, Photographer Spring 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey Joseph Hill, Photographer Spring 1937 DETAIL OF CORNICE AND SECOND FLOOR WINDOW TRIM. - Rock Island Arsenal, Building No. 346, Davenport Drive, Arsenal Grounds, Rock Island, Rock Island County, IL

  19. 1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer July 1936 FENCE RAILING 1133 WEST WASHINGTON BLVD. - Chicago Ironwork, 1133 West Washington Boulevard (Cast Iron Fence & Railing), 1133 West Washington Boulevard, Chicago, Cook County, IL

  20. 1. Historic American Buildings Survey Joseph Hill, Photographer July, 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer July, 1936 PORCH RAILING, 1149 W. WASHINGTON Blvd. - Chicago Ironwork, 1149 West Washington Boulevard (Cast Iron Stair Railing), 1149 West Washington Boulevard, Chicago, Cook County, IL

  1. 4. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI PHOTOGRAPHER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. HISTORIC AMERICAN BUILDINGS SURVEY JOSEPH T. GOLABOWSKI - PHOTOGRAPHER - APRIL 10, 1934. COLUMN AND PIER DETAIL - LOOKING UP - Presbyterian Church, West Cherry & North Mechanic Streets, Winchester, Scott County, IL

  2. Sewage-sludge-derived carbonaceous materials for catalytic wet hydrogen peroxide oxidation of m-cresol in batch and continuous reactors.

    PubMed

    Yu, Yang; Wei, Huangzhao; Yu, Li; Wang, Wei; Zhao, Ying; Gu, Bin; Sun, Chenglin

    2016-01-01

    In this study, four sewage-sludge-derived carbonaceous materials (SWs) were evaluated for their catalytic wet hydrogen peroxide oxidation (CWPO) performance of m-cresol in batch reactor and continuous reactor, respectively. The SWs were produced by carbonization (SW); carbonization with the addition of CaO (CaO-SW); HNO3 pretreatment (HNO3-SW) and steam activation (Activated-SW). The properties of SW catalysts were assessed by thermogravimetric analysis, Brunauer-Emmett-Teller, Fourier Transform Infrared Spectroscopy, X-ray Fluorescence, Scanning electron microscopy, energy dispersive X-ray analysis and zeta potential. The results showed that SW treated by HNO3 (HNO3-SW) had a high conversion of m-cresol in batch reactor and continuous reactor, respectively. Under the conditions of batch reaction (Cm-cresol = 100 mg L(-1), CH2O2 = 15.7 mmol L(-1), initial pH=7.0, 0.5 g L(-1) catalyst, 80°C, 180 min adsorption and 210 min oxidation), the conversion of m-cresol reached 100% and total organic carbon removal was 67.1%. It had a high catalytic activity and stability on the treatment of m-cresol in CWPO for more than 1100 h. Furthermore, a possible reaction mechanism for the oxidation of m-cresol to 2-methyl-p-benzoquinone by CWPO was proposed.

  3. Proposed Consent Agreement and Final Order: Joseph O’Meara, Joseph O’Meara Living Trust, and Killarney West Golf Course, Inc.

    EPA Pesticide Factsheets

    EPA's proposed Consent Agreement and Final Order in the matter of Joseph O’Meara, Joseph O’Meara Living Trust, and Killarney West Golf Course, Inc. for violations of the Clean Water Act in Hillsboro, Oregon.

  4. Proposed Penalty Against Joseph O’Meara, Joseph O’Meara Living Trust, and Killarney West Golf Course, Inc. for Clean Water Act Violations

    EPA Pesticide Factsheets

    Public notice of EPA's proposed penalty against Joseph O’Meara, Joseph O’Meara Living Trust, and Killarney West Golf Course, Inc. for violations of the Clean Water Act at their facility in Hillsboro, Oregon.

  5. Association between Machado-Joseph disease and oxidative stress biomarkers.

    PubMed

    Pacheco, Laura Segabinazzi; da Silveira, Aron Ferreira; Trott, Alexis; Houenou, Lucien J; Algarve, Thaís Doeler; Belló, Caroline; Lenz, Adriano Flesch; Mânica-Cattani, Maria Fernanda; da Cruz, Ivana Beatrice Mânica

    2013-10-09

    Spinocerebellar ataxia type 3, also called Machado-Joseph disease (MJD), is an hereditary autosomal dominant neurodegenerative disease that affects the cerebellum and its afferent and efferent connections. Since the mechanism by which mutant ataxin-3 eventually leads to neuronal death is poorly understood, additional investigations to clarify the biological alterations related to Machado-Joseph disease are necessary. Recent investigations suggest that oxidative stress may contribute significantly to Machado-Joseph disease. We compared markers of oxidative stress between Machado-Joseph disease and healthy control subjects. The results showed that Machado-Joseph patients have higher catalase levels and lower thiol protein levels compared to control subjects. The peripheral blood lymphocyes of MJD patients also showed higher levels of DNA damage by the comet assay than control subjects. Our results corroborate the hypothesis that the oxidative stress is associated with MJD patients. However, whether strategies to increase cellular antioxidative capacity may be effective therapies for the treatment of Machado-Joseph disease is an open question. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Joseph Rotblat: influences, scientific achievements and legacy

    NASA Astrophysics Data System (ADS)

    Underwood, Martin

    2008-11-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to science, and in particular to the medical applications of accelerators, radiation and radio-nuclides. In this article his early work and influences in Poland are described. He then joined James Chadwick at Liverpool University and began work on the cyclotron recently constructed there. Rotblat then, together with Chadwick, joined the Manhattan Project. This experience was to shape his life. He stayed at Los Alamos for less than a year before walking out. He was suspected of being a spy. Rotblat then became Professor of Physics at St Bartholomew's Medical College and pioneered the use of a 15 MeV linear accelerator in treatment and research. He made fundamental contributions to understanding the effects of the fallout from nuclear bomb tests. He also, together with Patricia Lindop, made important contributions to understanding the biological effects of radiation.

  7. Joseph Priestley, oxygen, and the enlightenment.

    PubMed

    West, John B

    2014-01-01

    Joseph Priestley (1733–1804) was the first person to report the discovery of oxygen and describe some of its extraordinary properties. As such he merits a special place in the history of respiratory physiology. In addition his descriptions in elegant 18th-century English were particularly arresting, and rereading them never fails to give a special pleasure. The gas was actually first prepared by Scheele (1742–1786) but his report was delayed. Lavoisier (1743–1794) repeated Priestley's initial experiment and went on to describe the true nature of oxygen that had eluded Priestley, who never abandoned the erroneous phlogiston theory. In addition to oxygen, Priestley isolated and characterized seven other gases. However, most of his writings were in theology because he was a conscientious clergyman all his life. Priestley was a product of the Enlightenment and argued that all beliefs should be able to stand the scientific scrutiny of experimental investigations. As a result his extreme liberal views were severely criticized by the established Church of England. In addition he was a supporter of both the French and American Revolutions. Ultimately his political and religious attitudes provoked a riot during which his home and his scientific equipment were destroyed. He therefore emigrated to America in 1794 where his friends included Thomas Jefferson and Benjamin Franklin. He settled in Northumberland, Pennsylvania although his scientific work never recovered from his forced departure. But the descriptions of his experiments with oxygen will always remain a high point in the history of respiratory physiology.

  8. [Bioethical arguments in Joseph Ratzinger's thinking].

    PubMed

    Martínez-Carbonell López, Alfonso

    2014-01-01

    In the dense theological thought of Joseph Ratzinger before his election as pope, we find fundamental contributions to contemporary bioethics. Starting from the assumption of the close relationship between faith and science he incorporates a necessary theological dimension in the bioethical dialogue that illuminates and clarifies the answers to the real questions raised in bioethical actions. On the one hand, there is the question of the origin of man that is understood as God's creation as opposed to a purely biological origin to which a modern pseudoscientific stance wants to confine it. On the other hand, there is the question about man's identity, which is understood as the image of God, from which stems the inviolable dignity and sacredness of human life, overcoming scientistic materialism. Finally, we find the question of how to treat the ″other″, even the embryo, as a result of its lofty dignity, analyzing the ethical and legal consequences that exude from their nature and are summarized in the duty to protect and respect the other which the law should protect against the abuse of those who are stronger.

  9. Joseph Henry's Conception of Scientific Knowledge

    NASA Astrophysics Data System (ADS)

    Theerman, Paul

    1997-04-01

    Joseph Henry, America's premier physicist and physics teacher in the mid-nineteenth century, had decided views of scientific knowledge. These were expressed in two ways. First of all, scientific knowledge led to moral betterment. Thus the study of science was a morally good thing. This was not only because it led to the contemplation of God's creation, which was a standard reason justifying the study of science dating from the Scientific Revolution and even earlier. More importantly, the study of science itself was a moral discipline, imparting to scientists the habits and virtues of truthfulness, respect for others, care and diligence, and the discernment of meaningful patterns from experience. The moral ideals of science were expressed most strongly in Henry's upholding the international "Republic of Science"; conversely, cheapening science was a sign of moral failure. Second, for Henry and his generation, science provided a path to sure truth, separate from falsehood of both the politics and the quackery that characterized mid-century public life. Henry promoted this in his championing of the Smithsonian Institution a scientific establishment, against the ideas of others who wanted to make it a literary establishment or a training school for teachers. For Henry, the Smithsonian's scientific reputation would be established by relying on careful peer review in its publications, and supporting established scientists to write authoritative popular works. The purpose of both these activities was to raise the profile of science in the United States and further establish science and the scientific method as a guide to public life.

  10. 2016 Inspection and Annual Site Status Report for the Site A/Plot M, Illinois, Decommissioned Reactor Site July 2016

    SciTech Connect

    Murl, Jeffrey; Miller, Michele

    2016-07-01

    The Site A/Plot M, Illinois, Decommissioned Reactor Site was inspected on May 17, 2016. The site, located within Cook County forest preserve that is open to the public, was found to be in good condition with one exception. Erosion on top of the grass-covered mound at Plot M continues to be a concern as presented in previous inspections. Ruts form in the soil on top of Plot M as a result of bike traffic using the open field as a pass thru between established bike trails within the forest preserve. Argonne National Laboratory (ANL) who is contracted directly from U.S. Department of Energy (DOE) has filled in the ruts with top soil and reseeding remains an ongoing process. Reseeded areas from 2015 are progressing nicely. No cause for a follow-up inspection was identified. In 2015, ANL plugged and abandoned 8 of 25 monitoring wells (BH41, BH51, BH52, BH54, DH9, DH10, DH13, and DH17). The 17 groundwater monitoring wells remaining at the site were inspected to confirm that they were locked and in good condition. Preliminary environmental monitoring results for 2015 are provided in a draft report titled Surveillance of Site A and Plot M, Report for 2015, prepared by ANL. The report also contains results of an independent analysis conducted by the Illinois Emergency Management Agency on some of the samples collected by ANL in 2015. The draft report states that the results of the surveillance program continue to indicate that the impact of radioactivity at Site A/Plot M is very low and does not endanger the health of those living in the area or visiting the site. The ANL monitoring report will be made available to the public on the DOE Office of Legacy Management public website when it is issued as final. A new county forest preserve campsite opened in 2015 at Bull Frog Lake, which is east of Plot M. Hiking trails connect Bull Frog Lake with Site A/Plot M. The site might receive more traffic from forest preserve visitors now that this new campsite is opened.

  11. Biomass granulation in an upflow anaerobic sludge blanket reactor treating 500 m(3)/day low-strength sewage and post treatment in high-rate algal pond.

    PubMed

    Chatterjee, Pritha; Ghangrekar, M M

    2017-09-01

    A pilot-scale upflow anaerobic sludge blanket-moving bed biofilm (UASB-MBB) reactor followed by a high-rate algal pond (HRAP) was designed and operated to remove organic matter, nutrients and pathogens from sewage and to facilitate reuse. For an influent chemical oxygen demand (COD) concentration of 233 ± 20 mg/L, final effluent COD was 50 ± 6 mg/L. Successful biomass granulation was observed in the sludge bed of the upflow anaerobic sludge blanket (UASB) reactor after 5 months of operation. Ammonia removal in HRAP was 85.1 ± 2.4% with average influent and effluent ammonia nitrogen concentrations of 20 ± 3 mg/L and 3 ± 1 mg/L, respectively. Phosphate removal after treatment in the HRAP was 91 ± 1%. There was a 2-3 log scale pathogen removal after treatment in HRAP with most probable number (MPN) of the final effluent being 600-800 per 100 mL, which is within acceptable standards for surface irrigation. The blackwater after treatment in UASB-MBBR-HRAP is being reused for gardening and landscaping. This proper hydro-dynamically designed UASB reactor demonstrated successful granulation and moving bed media improved sludge retention in UASB reactor. This combination of UASB-MBB reactor followed by HRAP demonstrated successful sewage treatment for a year covering all seasons.

  12. Accumulation of radioactive corrosion products on steel surfaces of VVER type nuclear reactors. I. 110mAg

    NASA Astrophysics Data System (ADS)

    Hirschberg, Gábor; Baradlai, Pál; Varga, Kálmán; Myburg, Gerrit; Schunk, János; Tilky, Péter; Stoddart, Paul

    Formation, presence and deposition of corrosion product radionuclides (such as 60Co, 51Cr, 54Mn, 59Fe and/or 110mAg) in the primary circuits of water-cooled nuclear reactors (PWRs) throw many obstacles in the way of normal operation. During the course of the work presented in this series, accumulations of such radionuclides have been studied at austenitic stainless steel type 08X18H10T (GOST 5632-61) surfaces (this austenitic stainless steel corresponds to AISI 321). Comparative experiments have been performed on magnetite-covered carbon steel (both materials are frequently used in some Soviet VVER type PWRs). For these laboratory-scale investigations a combination of the in situ radiotracer `thin gap' method and voltammetry is considered to be a powerful tool due to its high sensitivity towards the detection of the submonolayer coverages of corrosion product radionuclides. An independent technique (XPS) is also used to characterize the depth distribution and chemical state of various contaminants in the passive layer formed on austenitic stainless steel. In the first part of the series the accumulation of 110mAg has been investigated. Potential dependent sorption of Ag + ions (cementation) is found to be the predominant process on austenitic steel, while in the case of magnetite-covered carbon steel the silver species are mainly depleted in the form of Ag 2O. The XPS depth profile of Ag gives an evidence about the embedding of metallic silver into the entire passive layer of the austenitic stainless steel studied.

  13. Development of a hybrid microbial fuel cell (MFC) and fuel cell (FC) system for improved cathodic efficiency and sustainability: the M2FC reactor.

    PubMed

    Eom, Heonseop; Chung, Kyungmi; Kim, Ilgook; Han, Jong-In

    2011-10-01

    In an effort to improve the efficiency and sustainability of microbial fuel cell (MFC) technology, a novel MFC reactor, the M2FC, was constructed by combining a ferric-based MFC with a ferrous-based fuel cell (FC). In this M2FC reactor, ferric ion, the catholyte in the MFC component, is regenerated by the FC system with the generation of additional electricity. When the MFC component was operated separately, the electricity generation was maintained for only 98 h due to the depletion of ferric ion in the catholyte. In combination with the fuel cell, however, the production of power was sustained because ferric ion was continually replenished from ferrous ion in the FC component. Moreover, the regeneration process of ferric ion by the FC produced additional energy. The M2FC reactor yielded a power density of up to 2 W m(-2) (or time-averaged value of approximately 650 mW m(-2)), density up to 20 times (or approximately six times based on time-averaged value) higher than the corresponding MFC system.

  14. Clinical evaluation of oropharyngeal dysphagia in Machado-Joseph disease.

    PubMed

    Corrêa, Sabrina Mello Alves; Felix, Valter Nilton; Gurgel, Jonas Lírio; Sallum, Rubens A A; Cecconello, Ivan

    2010-01-01

    In Machado-Joseph disease, poor posture, dystonia and peripheral neuropathy are extremely predisposing to oropharyngeal dysphagia, which is more commonly associated with muscular dystrophy. To evaluate the clinical characteristics of oropharyngeal dysphagia in Machado-Joseph disease patients. Forty individuals participated in this study, including 20 with no clinical complaints and 20 dysphagic patients with Machado-Joseph disease of clinical type 1, who were all similar in terms of gender distribution, average age, and cognitive function. The medical history of each patient was reviewed and each subject underwent a clinical evaluation of deglutition. At the end, the profile of dysphagia in patients with Machado-Joseph disease was classified according to the Severity Scale of Dysphagia, as described by O'Neil and collaborators. Comparison between dysphagic patients and controls did not reveal many significant differences with respect to the clinical evaluation of the oral phase of deglutition, since afflicted patients only demonstrated deficits related to the protrusion, retraction and tonus of the tongue. However, several significant differences were observed with respect to the pharyngeal phase. Dysphagic patients presented pharyngeal stasis during deglutition of liquids and solids, accompanied by coughing and/or choking as well as penetration and/or aspiration; these signs were absent in the controls. Oropharyngeal dysphagia is part of the Machado-Joseph disease since the first neurological manifestations. There is greater involvement of the pharyngeal phase, in relation to oral phase of the deglutition. The dysphagia of these patients is classified between mild and moderate.

  15. The use of MOX caramel fuel mixed with (241)Am, (242m)Am and (243)Am as burnable absorber actinides for the MTR research reactors.

    PubMed

    Shaaban, Ismail; Albarhoum, Mohamad

    2017-07-01

    The MOX (UO2&PuO2) caramel fuel mixed with (241)Am, (242m)Am and (243)Am as burnable absorber actinides was proposed as a fuel of the MTR-22MW reactor. The MCNP4C code was used to simulate the MTR-22MW reactor and estimate the criticality and the neutronic parameters, and the power peaking factors before and after replacing its original fuel (U3O8-Al) by the MOX caramel fuel mixed with (241)Am, (242m)Am and (243)Am actinides. The obtained results of the criticality, the neutronic parameters, and the power peaking factors for the MOX caramel fuel mixed with (241)Am, (242m)Am and (243)Am actinides were compared with the same parameters of the U3O8-Al original fuel and a maximum difference is -6.18% was found. Additionally, by recycling 2.65% and 2.71% plutonium and (241)Am, (242m)Am and (243)Am actinides in the MTR-22MW reactor, the level of (235)U enrichment is reduced from 4.48% to 3% and 2.8%, respectively. This also results in the reduction of the (235)U loading by 32.75% and 37.22% for the 2.65%, the 2.71% plutonium and (241)Am, (242m)Am and (243)Am actinides, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Heat production in depth up to 2500m via in situ combustion of methane using a counter-current heat-exchange reactor

    NASA Astrophysics Data System (ADS)

    Schicks, Judith Maria; Spangenberg, Erik; Giese, Ronny; Heeschen, Katja; Priegnitz, Mike; Luzi-Helbing, Manja; Thaler, Jan; Abendroth, Sven; Klump, Jens

    2014-05-01

    In situ combustion is a well-known method used for exploitation of unconventional oil deposits such as heavy oil/bitumen reservoirs where the required heat is produced directly within the oil reservoir by combustion of a small percentage of the oil. A new application of in situ combustion for the production of methane from hydrate-bearing sediments was tested at pilot plant scale within the first phase of the German national gas hydrate project SUGAR. The applied method of in situ combustion was a flameless, catalytic oxidation of CH4 in a counter-current heat-exchange reactor with no direct contact between the catalytic reaction zone and the reservoir. The catalyst permitted a flameless combustion of CH4 with air to CO2 and H2O below the auto-ignition temperature of CH4 in air (868 K) and outside the flammability limits. This led to a double secured application of the reactor. The relatively low reaction temperature allowed the use of cost-effective standard materials for the reactor and prevented NOx formation. Preliminary results were promising and showed that only 15% of the produced CH4 was needed to be catalytically burned to provide enough heat to dissociate the hydrates in the environment and release CH4. The location of the heat source right within the hydrate-bearing sediment is a major advantage for the gas production from natural gas hydrates as the heat is generated where it is needed without loss of energy due to transportation. As part of the second period of the SUGAR project the reactor prototype of the first project phase was developed further to a borehole tool. The dimensions of this counter-current heat-exchange reactor are about 540 cm in length and 9 cm in diameter. It is designed for applications up to depths of 2500 m. A functionality test and a pressure test of the reactor were successfully carried out in October 2013 at the continental deep drilling site (KTB) in Windischeschenbach, Germany, in 600 m depth and 2000 m depth, respectively

  17. [Joseph Toynbee--otologist, scientist, philanthropist].

    PubMed

    Betlejewski, Stanisław; Betlejewski, Andrzej

    2009-01-01

    Joseph Tonbee's life's work may be summarized in the words of William Wilde: "The labours and investigations of Mr. Toynbee have affected more for aural pathology than those of all his predecessors either in England or on the continent". Some idea of the extent of his researches is given by the fact that he dissected some 2.000 ears. These preparations formed the Toynbee Collection in the Museum of the Royal College of Surgeons of England. He wrote the results of his researches in a catalogue that includes the description of 1,659 human ears. This catalogue forms the basis of modern otology for all time. This purely pathological catalogue was completed in 1860 with the publication of a more clinical book, "The Diseases of the Ear: their Nature, Diagnosis and Treatment". Toynbee appears to have been the first to describe the pathological changes in otosclerosis. In his book "Diseases of the Ear" he described the condition clearly, recognizing "anchylosis of the stapes to the fenestra ovalis" in 136 temporal bones. He also aligned the subjective, visual and ausculatory tests for Eustacchian tubal patency which we use today. Adam Politzer wrote: "Toynbee was the first who realized in otology that therapeutic progress depends on the knowledge of anatomy". But Toynbee was also active on other fields. Politzer, in his lecture in Vienna in 1914 said: "Toynbee was as outstanding a savant as he was a philanthropist. In addition to his scientific activity, he considered it a sacred task to dedicate his spare time to the improvement of living and health conditions of the poorer classes." Tragic enough, Toynbee's zeal for clinical experimentation went too far. Seeking to help his patients by devising a treatment to allay their tinnitus, he conceived the idea of introducing a mixture of chloroform and prussic acid into the tympanic cavity by means of Valsalva maneuver. When he made the first trial on July 7, 1866, with himself as a subject, he was found dead on the couch in his

  18. A comparison of rat SPECT images obtained using 99mTc derived from 99Mo produced by an electron accelerator with that from a reactor

    NASA Astrophysics Data System (ADS)

    Galea, R.; Wells, R. G.; Ross, C. K.; Lockwood, J.; Moore, K.; Harvey, J. T.; Isensee, G. H.

    2013-05-01

    Recent shortages of molybdenum-99 (99Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce 99Mo from which technetium-99m (99mTc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced 99mTc with those obtained using 99mTc from a commercial generator were compared. Disks of 100Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of 99Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the 99mTc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using 99mTc from a standard reactor 99Mo generator. The efficiency of 99Mo-99mTc separation was typically greater than 90%. This study demonstrated the delivery of 99mTc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced 99mTc were comparable. High-power electron accelerators are an attractive option for producing 99Mo on a national scale.

  19. A comparison of rat SPECT images obtained using (99m)Tc derived from 99Mo produced by an electron accelerator with that from a reactor.

    PubMed

    Galea, R; Wells, R G; Ross, C K; Lockwood, J; Moore, K; Harvey, J T; Isensee, G H

    2013-05-07

    Recent shortages of molybdenum-99 ((99)Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce (99)Mo from which technetium-99m ((99m)Tc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced (99m)Tc with those obtained using (99m)Tc from a commercial generator were compared. Disks of (100)Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of (99)Mo per disk. After target dissolution, a NorthStar ARSII unit was used to separate the (99m)Tc, which was subsequently used to tag pharmaceuticals suitable for cardiac and bone imaging. SPECT images were acquired for three rats and compared to images for the same three rats obtained using (99m)Tc from a standard reactor (99)Mo generator. The efficiency of (99)Mo-(99m)Tc separation was typically greater than 90%. This study demonstrated the delivery of (99m)Tc from the end of beam to the end user of approximately 30 h. Images obtained using the heart and bone scanning agents using reactor and linac-produced (99m)Tc were comparable. High-power electron accelerators are an attractive option for producing (99)Mo on a national scale.

  20. Saint Joseph's University Institute for Environmental Stewardship

    SciTech Connect

    McCann, Micahel P.; Springer, Clint J.

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in terms of

  1. [Joseph Carey Merrick the man in the flannel mask].

    PubMed

    Rimar, Yossi

    2007-02-01

    Joseph Carey Merrick was born like all other children in his time, yet his life story was unlike those of other people due to an odd disfiguring disease that devastated his appearance. Despite his personal and social handicap caused by his deformity, Joseph Merrick did his best to survive the challenges of every-day living in a hostile and unsympathetic world. This is the story of a man who had to cover his face from the crows behind a mask, a man whose bones have yet to find eternal peace. This is the story of the "elephant man".

  2. Component-Level Prognostics Health Management Framework for Passive Components - Advanced Reactor Technology Milestone: M2AT-15PN2301043

    SciTech Connect

    Ramuhalli, Pradeep; Roy, Surajit; Hirt, Evelyn H.; Prowant, Matthew S.; Pitman, Stan G.; Tucker, Joseph C.; Dib, Gerges; Pardini, Allan F.

    2015-06-19

    This report describes research results to date in support of the integration and demonstration of diagnostics technologies for prototypical advanced reactor passive components (to establish condition indices for monitoring) with model-based prognostics methods. Achieving this objective will necessitate addressing several of the research gaps and technical needs described in previous technical reports in this series.

  3. Joseph Ames's "Typographical Antiquities" and the Antiquarian Tradition

    ERIC Educational Resources Information Center

    Shiner, Elaine

    2013-01-01

    One of the most famous historical documents of English printing is Joseph Ames's "Typographical Antiquities," published in London in 1749. Although Ames referred to his work as a history of printing, the bulk of it is a list of the first printers in England and their works through 1600, with very full bibliographical descriptions for…

  4. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    ERIC Educational Resources Information Center

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  5. Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

    Cancer.gov

    Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

  6. Using Joseph Campbell to Improve Students' Response to Literature.

    ERIC Educational Resources Information Center

    Barnum, Carol M.

    1992-01-01

    Shows how teachers can use the videotapes and writings of Joseph Campbell to help students see patterns in literature and respond personally to it. Presents Campbell's explanation of the monomyth of the hero's journey, and discusses three works in which the pattern is present. (SR)

  7. Perils of Accommodation: The Case of Joseph W. Holley

    ERIC Educational Resources Information Center

    O'Brien, Thomas V.

    2007-01-01

    This study examines accommodationism, a tactic of racial uplift used by black school founders and teachers in the Jim Crow South. For founders, accommodationism was a dangerous process of collaboration, resistance, and compromise. The subject under study is Joseph Winthrop Holley. Born in South Carolina, Holley studied in the North at Phillips…

  8. 1. Historic American Buildings Survey Joseph Hill, Photographer March 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer March 10, 1936 CAST IRON BALCONY RAIL AND WROUGHT IRON WINDOW RAILING 945 NORTH DEARBORN STREET, CHICAGO - Chicago Ironwork, Judge Carpenter House (Cast Iron Balcony Railing), 945 North Dearborn Street, Chicago, Cook County, IL

  9. Wesley Joseph McJulien: Leader, Teacher, and Media Pioneer.

    ERIC Educational Resources Information Center

    Wennberg, Hans-Erik

    2000-01-01

    Provides a profile of Wesley Joseph McJulien, an instructional technologist who provided leadership to the field throughout his professional career. Highlights include his educational background, teaching career in higher education, presidency of the Association for Educational Communications and Technology (AECT), and his role as spokesperson for…

  10. Interview with Dr Joseph Murray (by Francis L Delmonico).

    PubMed

    Murray, Joseph

    2002-10-01

    The Editors asked Dr Delmonico to interview Dr Joseph Murray, winner of the Nobel prize in Medicine 1990 for performing the first successful renal transplant, to record recollections of the issues of the 1950s, when clinical transplantation was born, on Dr Murray's medical career in transplantation, and on some contemporary issues.

  11. BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BRASS MILL #72 SLITTER, OPERATED BY JOSEPH WAGNER, FORMERLY AN EMPLOYEE OF REPUBLIC STEEL IN BUFFALO. BRASS STRIP FROM THE SLITTE IS USED ON THE BUFFALO PLANT'S CONTINUOUS SEAMLESS TUBE LINE. - American Brass Foundry, 70 Sayre Street, Buffalo, Erie County, NY

  12. Pioneer in Behavioral Pharmacology: A Tribute to Joseph V. Brady

    ERIC Educational Resources Information Center

    Barrett, James E.

    2008-01-01

    The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner ("conditioned emotional response") procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group…

  13. Inside and outside: Boxes Inspired by Joseph Cornell

    ERIC Educational Resources Information Center

    Winters, Laurel

    2009-01-01

    In this article, the author describes an art project inspired by the work of Joseph Cornell. The project called for designing both the outside and the inside of a cigar box according to the student's theme. Thus, students needed to consider the viewer's vantage point with the box both closed and open, general design elements, two-dimensional and…

  14. Perils of Accommodation: The Case of Joseph W. Holley

    ERIC Educational Resources Information Center

    O'Brien, Thomas V.

    2007-01-01

    This study examines accommodationism, a tactic of racial uplift used by black school founders and teachers in the Jim Crow South. For founders, accommodationism was a dangerous process of collaboration, resistance, and compromise. The subject under study is Joseph Winthrop Holley. Born in South Carolina, Holley studied in the North at Phillips…

  15. Visions and Re-Visions of Charles Joseph Minard.

    ERIC Educational Resources Information Center

    Friendly, Michael

    2002-01-01

    Describes the contributions of Charles Joseph Minard to statistical graphics, noting the time course of his work and providing background on his famous effort, the flow-map depiction of Napoleon's march on Moscow. Explores some modern re-visions of this famous graphic from an information visualization perspective. (SLD)

  16. Visions and Re-Visions of Charles Joseph Minard.

    ERIC Educational Resources Information Center

    Friendly, Michael

    2002-01-01

    Describes the contributions of Charles Joseph Minard to statistical graphics, noting the time course of his work and providing background on his famous effort, the flow-map depiction of Napoleon's march on Moscow. Explores some modern re-visions of this famous graphic from an information visualization perspective. (SLD)

  17. Joseph Lancaster and the History of Reading Instruction.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    Examining the origin and accomplishments of the Lancastrian monitorial system of instruction, this paper discusses the influence of that system on American education. It gives a brief history of how Joseph Lancaster became involved in reading instruction and how he was a pioneer in emphasizing a reading curriculum that was written down. It then…

  18. Pioneer in Behavioral Pharmacology: A Tribute to Joseph V. Brady

    ERIC Educational Resources Information Center

    Barrett, James E.

    2008-01-01

    The contributions of Joseph V. Brady to behavioral pharmacology span more than 50 years and range from early studies using the Estes-Skinner ("conditioned emotional response") procedure to examine drug effects and various physiological processes in experimental animals to the implementation of mobile methadone treatment services and to small group…

  19. Using Joseph Campbell to Improve Students' Response to Literature.

    ERIC Educational Resources Information Center

    Barnum, Carol M.

    1992-01-01

    Shows how teachers can use the videotapes and writings of Joseph Campbell to help students see patterns in literature and respond personally to it. Presents Campbell's explanation of the monomyth of the hero's journey, and discusses three works in which the pattern is present. (SR)

  20. Joseph v. Brady: Synthesis Reunites What Analysis Has Divided

    ERIC Educational Resources Information Center

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found…

  1. [The umbilical metastasis. Sister Mary Joseph and her time].

    PubMed

    Trebing, D; Göring, H-D

    2004-02-01

    Although Baluff in 1854 and Nelaton in 1860 had already described umbilical metastases, the best known description of the metastasis of carcinomas to this site as "trouser button navel" was published in 1928 by William James Mayo (1861-1939), son of William Worrall Mayo (1815-1911), the founder of the Mayo Clinic in Rochester, Minnesota, This phenomenon is supposed to have been pointed out to Mayo by his long-serving head surgical nurse Sister Mary Joseph (1856-1939). The English surgeon Hamilton Bailey, in his famous textbook "Physical Signs in Clinical Surgery" in 1949, coined the term "Sister Joseph's nodule" for an umbilical metastasis. The expression has become widely accepted and used. Sister Mary Joseph, daughter of Irish immigrants, belonged to the 3rd order of the Holy Francis, was distinguished for her skills, intelligence and devotion to nursing which was also her calling. She worked for many decades at the world-famous Mayo Clinic and taught generations of young nurses. In recent years, the original surgical building at Saint Mary's Hospital has been named "Joseph Building" in her memory. Among the numerous eponyms occurring in the dermatology and the medicine, the association with the name of a nurse represents beyond doubt a special feature.

  2. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    ERIC Educational Resources Information Center

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  3. Sister Mary Joseph's nodule that originated from lung adenocarcinoma.

    PubMed

    Haruki, Tomohiro; Nakamura, Hiroshige; Kubouchi, Yasuaki; Taniguchi, Yuji; Miwa, Ken; Adachi, Yoshin; Fujioka, Shinji; Ito, Hisao

    2011-03-01

    Umbilical metastasis of cancer, known as Sister Mary Joseph's nodule (SMJN), is a rare phenomenon. It is usually due to intraabdominal malignancies and is quite rare from lung cancer. Here we describe a case of SMJN that originated from advanced lung adenocarcinoma. SMJN should be noted as an important sign of some hidden malignancy including lung cancer.

  4. Joseph v. Brady: Synthesis Reunites What Analysis Has Divided

    ERIC Educational Resources Information Center

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found…

  5. Astronaut Joseph Kerwin forms perfect sphere with water droplet

    NASA Image and Video Library

    1973-06-01

    SL2-X9-730 (1 June 1973) --- Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, forms a perfect sphere by blowing water droplets from a straw in zero-gravity. He is in the crew quarters of the Skylab Orbital Workshop. Photo credit: NASA

  6. Transient analyses for the Uzbekistan VVR-SM reactor with IRT-3M HEU fuel and IRT-4M LEU fuel : ANL independent verification results.

    SciTech Connect

    Garner, P. L.; Hanan, N. A.; Nuclear Engineering Division

    2007-09-24

    Calculations have been performed for postulated transients in the VVR-SM Reactor at the Institute of Nuclear Physics (INP) of the Academy of Sciences in the Republic of Uzbekistan. (The reactor designation in Cyrillic is BBP-CM; transliterating characters to English gives VVRSM but translating words gives WWR-SM.) These calculations have been performed at the request of staff of the INP who are performing similar calculations. The transients considered were established during working meetings between Argonne National Laboratory (ANL) and INP staff during summer 2006 [Ref. 1], subsequent email correspondence, and subsequent staff visits. Calculations were performed for the current high-enriched uranium (HEU) core, the proposed low-enriched uranium (LEU) core, and one mixed HEU-LEU core during the transition. These calculations have been performed independently from those being performed by INP and serve as one step in the verification process.

  7. Obituary: Joseph Wyan Chamberlain, 1928-2004

    NASA Astrophysics Data System (ADS)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  8. PREFACE: SANS-YuMO User Meeting at the Start-up of Scientific Experiments on the IBR-2M Reactor: Devoted to the 75th anniversary of Yu M Ostanevich's birth

    NASA Astrophysics Data System (ADS)

    Gordely, Valentin; Kuklin, Alexander; Balasoiu, Maria

    2012-03-01

    The Second International Workshop 'SANS-YuMO User Meeting at the Start-up of Scientific Experiments on the IBR-2M Reactor', devoted to the 75th anniversary of the birth of Professor Yu M Ostanevich (1936-1992), an outstanding neutron physicist and the founder of small-angle neutron scattering (field, group, and instrument) at JINR FLNPh, was held on 27-30 May at the Frank Laboratory of Neutron Physics. The first Workshop was held in October 2006. Research groups from different neutron centers, universities and research institutes across Europe presented more than 35 oral and poster presentations describing scientific and methodological results. Most of them were obtained with the help of the YuMO instrument before the IBR-2 shutdown in 2006. For the last four years the IBR-2 reactor has been shut down for refurbishment. At the end of 2010 the physical launch of the IBR-2M reactor was finally realized. Nowadays the small-angle neutron scattering (SANS) technique is applied to a wide range of scientific problems in condensed matter, soft condensed matter, biology and nanotechnology, and despite the fact that there are currently over 30 SANS instruments in operation worldwide at both reactor and spallation sources, the demand for beam-time is considerably higher than the time available. It must be remembered, however, that as the first SANS machine on a steady-state reactor was constructed at the Institute Laue Langevin, Grenoble, the first SANS instrument on a 'white' neutron pulsed beam was accomplished at the Joint Institute for Nuclear Research at the IBR-30 reactor, beamline N5. During the meeting Yu M Ostanevich's determinative and crucial contribution to the construction of spectrometers at the IBR-2 high-pulsed reactor was presented, as well as his contribution to the development of the time-of-flight (TOF) small-angle scattering technique, and a selection of other scientific areas. His leadership and outstanding scientific achievements in applications of the

  9. Space reactors

    NASA Astrophysics Data System (ADS)

    Ranken, W. A.

    1983-01-01

    Progress in design studies and technology for the SP-100 Project - successor to the Space Power Advanced Reactor (SPAR) Project - is reported for the period October 1, 1981 to March 31, 1982. The basis for selecting a high-temperature, UO2-fueled, heat-pipe-cooled reactor with a thermoelectric conversion system as the 100/kW-sub e/ reference design has been reviewed. Although no change has been made in the general concept, design studies have been done to investigate various reactor/conversion system coupling methods and core design modifications. Thermal and mechanical finite element modeling and three dimensional Monte Carlo analysis of a core with individual finned fuel elements are reported. Studies of unrestrained fuel irradiation data are discussed that are relevant both to the core modeling work and to the design and fabrication of the first in-pile irradiation test, which is also reported. Work on lithium-filled core heat pipe development is described, including the attainment of 15.6 kW/sub t/ operation at 1525 K for a 2-m-long heat pipe with a 15.7-mm outside diameter. The successful operation of a 5.5-m-long, lightweight potassium/titanium heat pipe at 760 K is described, and test results of a thermoelectric module with GaP-modified SiGe thermoelectric elements are presented.

  10. Fast Reactors

    NASA Astrophysics Data System (ADS)

    Esposito, S.; Pisanti, O.

    The following sections are included: * Elementary Considerations * The Integral Equation to the Neutron Distribution * The Critical Size for a Fast Reactor * Supercritical Reactors * Problems and Exercises

  11. Experimental Design for Evaluating Selected Nondestructive Measurement Technologies - Advanced Reactor Technology Milestone: M3AT-16PN2301043

    SciTech Connect

    Ramuhalli, Pradeep; Hirt, Evelyn H.; Pitman, Stan G.; Dib, Gerges; Roy, Surajit; Good, Morris S.; Walker, Cody M.

    2016-07-16

    The harsh environments in advanced reactors (AdvRx) increase the possibility of degradation of safety-critical passive components, and therefore pose a particular challenge for deployment and extended operation of these concepts. Nondestructive evaluation technologies are an essential element for obtaining information on passive component condition in AdvRx, with the development of sensor technologies for nondestructively inspecting AdvRx passive components identified as a key need. Given the challenges posed by AdvRx environments and the potential needs for reducing the burden posed by periodic in-service inspection of hard-to-access and hard-to-replace components, a viable solution may be provided by online condition monitoring of components. This report identifies the key challenges that will need to be overcome for sensor development in this context, and documents an experimental plan for sensor development, test, and evaluation. The focus of initial research and development is on sodium fast reactors, with the eventual goal of the research being developing the necessary sensor technology, quantifying sensor survivability and long-term measurement reliability for nondestructively inspecting critical components. Materials for sensor development that are likely to withstand the harsh environments are described, along with a status on the fabrication of reference specimens, and the planned approach for design and evaluation of the sensor and measurement technology.

  12. Joseph Rotblat, the bomb and anomalies from his archive.

    PubMed

    Underwood, Martin C

    2013-06-01

    Professor Sir Joseph Rotblat made significant contributions to nuclear physics and worked on the development of the atomic bomb. He walked out of the Manhattan Project after working there for less than a year, the only scientist to do so. Rotblat gave a comprehensive account of his time at Los Alamos. His Archive is now becoming available and papers contained therein are inconsistent with some aspects of his account. The reasons as to how such anomalies and contradictions could occur are considered.

  13. Chief Joseph Dam, Columbia River, Washington, Community Impact Reports,

    DTIC Science & Technology

    1980-05-01

    Corps of Engineers. . e . .. . UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (Wh.n Data Entered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS R PEFORE... CLASSIFICATION OF THIS PAGE (WIhwnt ata Ent .rd) CHIEF JOSEPH DAM COMMUNITY IMPACT REPORTS TABLE OF CONTENTS PRE-CONSTRUCTION ANALYSIS PUBLISHED...pool 10 feet to elevation 956 feet. Planned construction will temporarily occur in three stages : (1) phasing- in of construction activities in late 1974

  14. Science, alchemy and light: paintings by Joseph Wright of Derby.

    PubMed

    Dominiczak, Marek H

    2002-01-01

    This article considers two paintings by the English painter, Joseph Wright of Derby (1734-97), 'An Experiment on a Bird in the Air Pump' and 'The Alchemist in Search of the Philosopher's Stone' as painterly reflections on the early industrial culture. Particularly interesting in the "Experiment on a Bird" is the broad spectrum of spectator's reactions to the experiment; this can be related to the contemporary debate on the contextualization of science.

  15. Photocopy of photograph (from NBPPNSY, CSF 4036766) Joseph P. Garfinkel, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of photograph (from NBP-PNSY, CSF 4036-7-66) Joseph P. Garfinkel, photographer, July 20, 1966 oblique aerial photo taken from an altitude of approximately 6,000 feet; view north of Philadelphia Naval Base and Shipyard. Reserve basin (Haer no. Pa-387-W) is at left center of photograph. - Naval Base Philadelphia-Philadelphia Naval Shipyard, League Island, Philadelphia, Philadelphia County, PA

  16. Astronaut Paul Weitz gets physical examination from Astronaut Joseph Kerwin

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Astronaut Paul J. Weitz, Skylab 2 pilot, gets a physical examination by a fellow crewman during the 28-day Skylab 2 mission. Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot and a doctor of medicine, uses a stethoscope to check the Weitz's heartbeat. They are in the Orbital Workshop crew quarters of the Skylab 1 and 2 space station in Earth orbit. This photograph was taken by Charles Conrad Jr., Skylab 2 commander.

  17. Umbilical metastasis (Sister Joseph's nodule) from carcinoma of the vagina.

    PubMed

    Bakri, Y N; Subhi, J; Hashim, E; Senoussi, M

    1991-01-01

    A case is reported of a squamous cell carcinoma of the vagina with metastasis to the umbilicus (Sister Mary Joseph's nodule). Systemic cisplatinum chemotherapy resulted in partial response, however, the "nodule" was a sign of poor prognosis and indicative of short-term survival. To the best of our knowledge, this is the first report of umbilical metastasis from a primary carcinoma of the vagina.

  18. In praise of Joseph Priestley - the particle physicist!

    NASA Astrophysics Data System (ADS)

    Jones, G. T.

    1991-05-01

    Joseph Priestley (1733 - 1804), known more as a chemist, made important contributions to the evolution of our view of the structure of matter. To commemorate the notorious Birmingham riots of July 1791, during which his house was burnt and his work destroyed, and following which he left England for the United States after three years in London, this article highlights his major contribution to what we now call particle physics

  19. STS-97 Crew Interview: Joseph Tanner, MS1

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The STS-97 Mission Specialist Joseph Tanner is seen being interviewed. He answers questions about his inspiration to become an astronaut, his career path, and his training. He gives details on the mission's goals and significance, its payload, the rendez-vous with the International Space Station (ISS), and what it will be like to work knowing there is already a crew on board the ISS.

  20. NEUTRONIC REACTOR

    DOEpatents

    Fermi, E.; Zinn, W.H.; Anderson, H.L.

    1958-09-16

    Means are presenied for increasing the reproduction ratio of a gaphite- moderated neutronic reactor by diminishing the neutron loss due to absorption or capture by gaseous impurities within the reactor. This means comprised of a fluid-tight casing or envelope completely enclosing the reactor and provided with a valve through which the casing, and thereby the reactor, may be evacuated of atmospheric air.

  1. Hybrid reactors. [Fuel cycle

    SciTech Connect

    Moir, R.W.

    1980-09-09

    The rationale for hybrid fusion-fission reactors is the production of fissile fuel for fission reactors. A new class of reactor, the fission-suppressed hybrid promises unusually good safety features as well as the ability to support 25 light-water reactors of the same nuclear power rating, or even more high-conversion-ratio reactors such as the heavy-water type. One 4000-MW nuclear hybrid can produce 7200 kg of /sup 233/U per year. To obtain good economics, injector efficiency times plasma gain (eta/sub i/Q) should be greater than 2, the wall load should be greater than 1 MW.m/sup -2/, and the hybrid should cost less than 6 times the cost of a light-water reactor. Introduction rates for the fission-suppressed hybrid are usually rapid.

  2. Determination of neutron flux density distribution in the core with LEU fuel IRT-4M at the training reactor VR-1

    SciTech Connect

    Huml, O.

    2008-07-15

    The objective of this work was to determine the neutron flux density distribution in various places of the training reactor VR-1 Sparrow. This experiment was performed on the new core design C1, composed of the new low-enriched uranium fuel cells IRT-4M (19.7 %). This fuel replaced the old high-enriched uranium fuel IRT-3M (36 %) within the framework of the RERTR Program in September 2005. The measurement used the neutron activation analysis method with gold wires. The principle of this method consists in neutron capture in a nucleus of the material forming the activation detector. This capture can change the nucleus in a radioisotope, whose activity can be measured. The absorption cross-section values were evaluated by MCNP computer code. The gold wires were irradiated in seven different positions in the core C1. All irradiations were performed at reactor power level 1E8 (1 kW{sub therm}). The activity of segments of irradiated wires was measured by special automatic device called 'Drat' (Wire in English). (author)

  3. Superfund Record of Decision (EPA Region 10): Joseph Forest Products, Wallowa County, OR. (First remedial action), September 1992. Final report

    SciTech Connect

    Not Available

    1992-09-30

    The 18-acre Joseph Forest Products (JFP) site is a wood-processing facility in the City of Joseph, Wallowa County, Oregon. Land use in the area is predominantly industrial and agricultural. The City of Enterprise uses two springs located 4,000 feet from JFP to serve as its municipal water supply. In 1974, and again from 1977 to 1985, Joseph Forest Products, Inc., used the site as a lumber mill, processing wood into lumber products. The selected remedial action for the site includes demolishing contaminated onsite structures, including the process, storage, and mixing tanks, and the wooden structures and concrete slabs, followed by offsite disposal; decontaminating the concrete drip pad and tanks, followed by recycling or offsite disposal of debris; excavating surface and subsurface soil, with screening and segregation of hazardous waste for offsite disposal, with stabilization, if necessary, prior to disposal at appropriate facilities; backfilling any excavated areas; removing asbestos from the facility, with offsite disposal; removing underground storage tanks and any associated contaminated soil, with scrapping or offsite disposal; monitoring ground water; and implementing institutional controls, including deed and land use restrictions or environmental notices. The estimated capital cost for this remedial action is $550,000, with an annual O M cost of $24,000 for 3 years.

  4. Professor Joseph Warren Horton (1889-1967): biological engineer.

    PubMed

    Zeitlin, Gerald L

    2005-02-01

    Joseph Warren Horton graduated with a degree in electrical engineering from the Massachusetts Institute of Technology (MIT) in 1914. He became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. In the mid-1930s he was appointed the first leader of the newly created Department of Biological Engineering at MIT and in this position he made major contributions to the application of physics to human physiology, in particular by increasing the safety of explosive inhalational anaesthetic agents.

  5. Joseph Harris of Trevecka: Scientist, Artisan, Servant of the Crown

    NASA Astrophysics Data System (ADS)

    Griffiths, M.

    2012-01-01

    A major goal of natural philosophy in the early eighteenth century was the search for accurate positional longitude. This quest demanded the most precise instruments and the most meticulous observations in astronomy and geophysics. Joseph Harris strode across these disciplines making a valuable contribution to the studies of astronomy, navigation, horology and magnetic variation. He later served his country by standardising weights and measures of coinage as Assay Master at the Royal Mint. Yet his prowess is little known or acknowledged. This paper describes and examines his life and roles.

  6. ASTRONAUT KERWIN, JOSEPH P. - EXTRAVEHICULAR ACTIVITY (EVA) - SKYLAB (SL)-2

    NASA Image and Video Library

    1973-06-01

    S73-27562 (June 1973) --- Scientist-astronaut Joseph P. Kerwin, Skylab 2 science pilot, performs extravehicular activity (EVA) at the Skylab 1 and 2 space station cluster in Earth orbit, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the station. Kerwin is just outside the Airlock Module. Kerwin assisted astronaut Charles Conrad Jr., Skylab 2 commander, during the successful EVA attempt to free the stuck solar array system wing on the Orbital Workshop. Photo credit: NASA

  7. Astronaut Joseph R. Tanner works with PCG experiment on middeck

    NASA Image and Video Library

    1994-11-14

    On the Space Shuttle Atlantis' mid-deck, astronaut Joseph R. Tanner, mission specialist, works at area amidst several lockers onboard the Shuttle which support the Protein Crystal Growth (PCG) experiment. This particular section is called the Crystal Observation System, housed in the Thermal Enclosure System (COS/TES). Together with the Vapor Diffusion Apparatus (VDA), housed in a Single Locker Thermal Enclosure (SLTES) which is out of frame, the Cos/TES represents the continuing research into the structures of proteins and other macromolecules such as viruses.

  8. Joseph V. Brady: Synthesis Reunites What Analysis Has Divided

    PubMed Central

    Thompson, Travis

    2012-01-01

    Joseph V. Brady (1922–2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found their way into designing environments for astronauts as well as studying drug effects on human social behavior in microenvironments. Brady created translational neurobehavioral science before such a concept existed. One of his most lasting contributions was developing a framework for ethical decision making to protect the rights of the people who participate in scientific research. PMID:23450040

  9. BOILING REACTORS

    DOEpatents

    Untermyer, S.

    1962-04-10

    A boiling reactor having a reactivity which is reduced by an increase in the volume of vaporized coolant therein is described. In this system unvaporized liquid coolant is extracted from the reactor, heat is extracted therefrom, and it is returned to the reactor as sub-cooled liquid coolant. This reduces a portion of the coolant which includes vaporized coolant within the core assembly thereby enhancing the power output of the assembly and rendering the reactor substantially self-regulating. (AEC)

  10. HEU Measurements of Holdup and Recovered Residue in the Deactivation and Decommissioning Activities of the 321-M Reactor Fuel Fabrication Facility at the Savannah River Site

    SciTech Connect

    DEWBERRY, RAYMOND; SALAYMEH, SALEEM R.; CASELLA, VITO R.; MOORE, FRANK S.

    2005-03-11

    This paper contains a summary of the holdup and material control and accountability (MC&A) assays conducted for the determination of highly enriched uranium (HEU) in the deactivation and decommissioning (D&D) of Building 321-M at the Savannah River Site (SRS). The 321-M facility was the Reactor Fuel Fabrication Facility at SRS and was used to fabricate HEU fuel assemblies, lithium-aluminum target tubes, neptunium assemblies, and miscellaneous components for the SRS production reactors. The facility operated for more than 35 years. During this time thousands of uranium-aluminum-alloy (U-Al) production reactor fuel tubes were produced. After the facility ceased operations in 1995, all of the easily accessible U-Al was removed from the building, and only residual amounts remained. The bulk of this residue was located in the equipment that generated and handled small U-Al particles and in the exhaust systems for this equipment (e.g., Chip compactor, casting furnaces, log saw, lathes A & B, cyclone separator, Freon{trademark} cart, riser crusher, ...etc). The D&D project is likely to represent an important example for D&D activities across SRS and across the Department of Energy weapons complex. The Savannah River National Laboratory was tasked to conduct holdup assays to quantify the amount of HEU on all components removed from the facility prior to placing in solid waste containers. The U-235 holdup in any single component of process equipment must not exceed 50 g in order to meet the container limit. This limit was imposed to meet criticality requirements of the low level solid waste storage vaults. Thus the holdup measurements were used as guidance to determine if further decontamination of equipment was needed to ensure that the quantity of U-235 did not exceed the 50 g limit and to ensure that the waste met the Waste Acceptance Criteria (WAC) of the solid waste storage vaults. Since HEU is an accountable nuclear material, the holdup assays and assays of recovered

  11. NEUTRONIC REACTOR

    DOEpatents

    Daniels, F.

    1959-10-27

    A reactor in which at least a portion of the moderator is in the form of movable refractory balls is described. In addition to their moderating capacity, these balls may serve as carriers for fissionable material or fertile material, or may serve in a coolant capacity to remove heat from the reactor. A pneumatic system is used to circulate the balls through the reactor.

  12. NUCLEAR REACTOR

    DOEpatents

    Treshow, M.

    1961-09-01

    A boiling-water nuclear reactor is described wherein control is effected by varying the moderator-to-fuel ratio in the reactor core. This is accomplished by providing control tubes containing a liquid control moderator in the reactor core and providing means for varying the amount of control moderatcr within the control tubes.

  13. Response of the St. Joseph River to lake level changes during the last 12,000 years in the Lake Michigan basin

    USGS Publications Warehouse

    Kincare, K.A.

    2007-01-01

    The water level of the Lake Michigan basin is currently 177 m above sea level. Around 9,800 14C years B.P., the lake level in the Lake Michigan basin had dropped to its lowest level in prehistory, about 70 m above sea level. This low level (Lake Chippewa) had profound effects on the rivers flowing directly into the basin. Recent studies of the St. Joseph River indicate that the extreme low lake level rejuvenated the river, causing massive incision of up to 43 m in a valley no more than 1.6 km wide. The incision is seen 25 km upstream of the present shoreline. As lake level rose from the Chippewa low, the St. Joseph River lost competence and its estuary migrated back upstream. Floodplain and channel sediments partially refilled the recently excavated valley leaving a distinctly non-classical morphology of steep sides with a broad, flat bottom. The valley walls of the lower St. Joseph River are 12-18 m tall and borings reveal up to 30 m of infill sediment below the modern floodplain. About 3 ?? 108 m3 of sediment was removed from the St. Joseph River valley during the Chippewa phase lowstand, a massive volume, some of which likely resides in a lowstand delta approximately 30 km off-shore in Lake Michigan. The active floodplain below Niles, Michigan, is inset into an upper terrace and delta graded to the Calumet level (189 m) of Lake Chicago. In the lower portion of the terrace stratigraphy a 1.5-2.0 m thick section of clast-supported gravel marks the entry of the main St. Joseph River drainage above South Bend, Indiana, into the Lake Michigan basin. This gravel layer represents the consolidation of drainage that probably occurred during final melting out of ice-marginal kettle chains allowing stream piracy to proceed between Niles and South Bend. It is unlikely that the St. Joseph River is palimpsest upon a bedrock valley. The landform it cuts across is a glaciofluvial-deltaic feature rather than a classic unsorted moraine that would drape over pre-glacial topography

  14. Carl Sagan and Joseph Shklovsky: Intelligent Life in the Universe

    NASA Astrophysics Data System (ADS)

    Kurt, Vladimir

    J. S. Shklovsky and Carl Sagan played an outstanding role in modern astronomy. Their names are well known not only to professional astronomers, but also to millions of educated people in many countries, which are interested in modern state of science research. Among these trends of modern science, which are difficult to define, are such problems, as the creation of Solar system, the origin of life on Earth, the evolution of living organisms on Earth from the simplest viruses to Homo Sapiens, the evolution of intelligence and technology. Finally, both outstanding scientists were deeply interested in the problem of SETI (Search Extraterrestrial Intelligence), i.e. search of extraterrestrial civilizations and methods of making contacts with them. And both scientists were high professionals in their fields. Joseph Shklovsky was a theoretical astronomer in all fields of modern astronomy (geophysics and physics of the upper atmosphere of the Earth, Sun and Solar Corona, Interplanetary Medium and Solar Wind, Interstellar Medium, Supernova and their remnants, the Galaxy and galaxies, Quasars and Cosmology). There is hardly a field in modern astrophysics (except perhaps the theory of the interior structure of stars), where Joseph Shklovsky has not l a bright stamp of his talent…

  15. CONVECTION REACTOR

    DOEpatents

    Hammond, R.P.; King, L.D.P.

    1960-03-22

    An homogeneous nuclear power reactor utilizing convection circulation of the liquid fuel is proposed. The reactor has an internal heat exchanger looated in the same pressure vessel as the critical assembly, thereby eliminating necessity for handling the hot liquid fuel outside the reactor pressure vessel during normal operation. The liquid fuel used in this reactor eliminates the necessity for extensive radiolytic gas rocombination apparatus, and the reactor is resiliently pressurized and, without any movable mechanical apparatus, automatically regulates itself to the condition of criticality during moderate variations in temperature snd pressure and shuts itself down as the pressure exceeds a predetermined safe operating value.

  16. Research reactors

    SciTech Connect

    Tonneson, L.C.; Fox, G.J.

    1996-04-01

    There are currently 284 research reactors in operation, and 12 under construction around the world. Of the operating reactors, nearly two-thirds are used exclusively for research, and the rest for a variety of purposes, including training, testing, and critical assembly. For more than 50 years, research reactor programs have contributed greatly to the scientific and educational communities. Today, six of the world`s research reactors are being shut down, three of which are in the USA. With government budget constraints and the growing proliferation concerns surrounding the use of highly enriched uranium in some of these reactors, the future of nuclear research could be impacted.

  17. Leader and Spokesman for a People in Exile: Chief Joseph and the Nez Perce

    ERIC Educational Resources Information Center

    Jain, Samvit

    2009-01-01

    This article discusses Chief Joseph's surrender that marked the beginning of his diplomatic stand for justice in Indian Territory, where his tribe was forcibly exiled in accordance with American Indian policy of the time. Joseph battled for the repatriation of the Nez Perce through protests and other legal means, winning the support of the growing…

  18. Leader and Spokesman for a People in Exile: Chief Joseph and the Nez Perce

    ERIC Educational Resources Information Center

    Jain, Samvit

    2009-01-01

    This article discusses Chief Joseph's surrender that marked the beginning of his diplomatic stand for justice in Indian Territory, where his tribe was forcibly exiled in accordance with American Indian policy of the time. Joseph battled for the repatriation of the Nez Perce through protests and other legal means, winning the support of the growing…

  19. NATURAL BIOATTENUATION OF TRICHLOROETHENE AT THE ST. JOSEPH, MICHIGAN SUPERFUND SITE

    EPA Science Inventory

    Data from the St. Joseph, Michigan, Superfund Site were used in a peer-reviewed video entitled "Natural Bioattenuation of Trichloroethene at the St. Joseph, Michigan Superfund Site." Computer visualizations of the data set show how trichloroethene, or TCE, can degrade under natu...

  20. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    ERIC Educational Resources Information Center

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…

  1. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    ERIC Educational Resources Information Center

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…

  2. 78 FR 50098 - Notice of Inventory Completion: St. Joseph County Sheriff's Department, Centreville, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ..., MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The St. Joseph County Sheriff's..., Centreville, MI 49032, telephone (269) 467-9045. SUPPLEMENTARY INFORMATION: Notice is here given in accordance.... The human remains were removed from Section 27, Leonidas Township, St. Joseph County, MI. This...

  3. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba (Petitioners...

  4. The Chief Joseph Hatchery Program 2014 Annual Report

    USGS Publications Warehouse

    Pearl, Andrea; Laramie, Matthew; Baldwin, Casey; Rohrback, John; Phillips, Pat

    2017-01-01

    The Chief Joseph Hatchery Program is comprised of both operations and maintenance of the Chief Joseph Hatchery, located near Bridgeport, Washington and the monitoring and evaluation of natural- and hatchery-origin Chinook salmon in the Okanogan Subbasin. In 2014, the Chief Joseph Hatchery released 44,267 yearling and 186,050 subyearling integrated Chinook from the Omak acclimation pond, and 265,656 subyearling segregated Chinook from the hatchery. Full production potential was not met at the hatchery for brood year 2014 because of higher than anticipated pre-spawn mortality in the broodstock. The total Chinook spawn in 2014 included, 132 hatcheryorigin Spring Chinook (66 male, 66 female)(21% of full program), 498 natural-origin summer/fall Chinook (250 male, 248 female)(83% of full program), and 453 hatcheryorigin Summer/Fall Chinook (223 male, 230 female)(92%). Two hundred thousand Spring Chinook parr were received in late October at the Riverside Acclimation Pond from the Winthrop National Fish Hatchery (100% of full production). These fish will be released in the spring of 2015 and mark the beginning of implementation of the non-essential experimental population under section 10(j) of the Endangered Species Act. Monitoring and evaluation consist primarily of operating rotary screw traps on the Okanogan River to monitor juvenile production and outmigration, beach seining and PIT tagging operations at the confluence of the Okanogan and Columbia Rivers, the operation of an adult pilot weir on the Okanogan River, and redd and carcass surveys on the Okanogan and Similkameen rivers. In 2014, the rotary screw traps captured 22,073 natural-origin Chinook, and estimated total juvenile outmigration was 3,265,309 (95% C. I. = 1,809,367- 4,721,251). Via the beach seine, 9,133 juvenile Chinook were captured, and 8,226 were released with an implanted PIT tag. 2,324 adult Chinook were encountered in the weir trap, of which 318 were hatchery-origin and 2,006 were natural

  5. NEUTRONIC REACTOR

    DOEpatents

    Fraas, A.P.; Mills, C.B.

    1961-11-21

    A neutronic reactor in which neutron moderation is achieved primarily in its reflector is described. The reactor structure consists of a cylindrical central "island" of moderator and a spherical moderating reflector spaced therefrom, thereby providing an annular space. An essentially unmoderated liquid fuel is continuously passed through the annular space and undergoes fission while contained therein. The reactor, because of its small size, is particularly adapted for propulsion uses, including the propulsion of aircraft. (AEC)

  6. Joseph Gurney Barclay and the 1860 10-inch Cooke refractor

    NASA Astrophysics Data System (ADS)

    Barclay, C. E.

    2006-12-01

    Joseph Gurney Barclay (1816-1898) was a partner in the banking firm of Barclay, Bevan & Co. He was, like his grandfather, Robert Barclay of Clapham, a keen Astronomer who observed regularly at his home Knotts Green House in Leyton, Essex, England, and he was a frequent contributor to the Monthly Notices of the Royal Astronomical Society. Employing professional astronomers, he made many original observations, especially following the acquisition of a 10-inch Cooke refractor in 1860. Gifted to the Radcliffe Observatory, Oxford in 1885, the 'Barclay Equatorial' continued in professional use until 1935 when it was removed to Marlborough College in Wiltshire, England, where it is now in full computerized use following complete restoration.

  7. Neurology and surrealism: André Breton and Joseph Babinski.

    PubMed

    Haan, Joost; Koehler, Peter J; Bogousslavsky, Julien

    2012-12-01

    Before he became the initiator of the surrealist movement, André Breton (1896-1966) studied medicine and worked as a student in several hospitals and as a stretcher bearer at the front during World War I. There he became interested in psychiatric diseases such as hysteria and psychosis, which later served as a source of inspiration for his surrealist writings and thoughts, in particular on automatic writing. Breton worked under Joseph Babinski at La Pitié, nearby La Salpêtrière, and became impressed by the 'sacred fever' of the famous neurologist. In this article, we describe the relationship between Breton and Babinski and try to trace back whether not only Breton's psychiatric, but also his neurological experiences, have influenced surrealism. We hypothesize that Breton left medicine in 1920 partly as a consequence of his stay with Babinski.

  8. Opportunity View of Private Joseph Field on Mars

    NASA Image and Video Library

    2016-12-07

    This image of a target called "Private Joseph Field" combines four images from the microscopic imager on the robotic arm of NASA's Mars Exploration Rover Opportunity, with enhanced color information added from the rover's panoramic camera. This target is within the "Marathon Valley" area of the western rim of Endeavour Crater. The component images were taken on May 29, 2016, during the 4,389th Martian day, or sol, of Opportunity's work on Mars. The mosaic shows an area spanning about 2 inches (5 centimeters). Geochemical data indicate the presence of magnesium and iron sulfates at this location, most likely corresponding to the white pebble visible near the center of the image. These sulfates may have formed by the interaction of acidic fluids with the rocks along the rim of Endeavour crater. http://photojournal.jpl.nasa.gov/catalog/PIA21142

  9. Joseph Rotblat: Moral Dilemmas and the Manhattan Project

    NASA Astrophysics Data System (ADS)

    Veys, Lucy

    2013-12-01

    John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.

  10. [François Joseph Double and auscultation].

    PubMed

    Suspène, Michel

    2007-01-01

    François-Joseph Double, co-founder of the Académie de Médecine, was one of those doctors who, right at the beginning of the nineteenth century, developped the accurate observation of the clinical signs of illness, which called earlier practice into question. This led him to study the unaided auscultation of respiratory and cardiac ailments. Shortly before Laennec's fundamental discovery of aided auscultation, Double was describing different sorts of sounds such as those which would later be called tubal breathing, and pulmonary rales or crackles; listening to the heart, he concentrated on problems of the beat, on unusual sounds but did not know how to link them to any specific ailment. The fact that his findings precede those of Laennec have not allowed him the recognition that his pioneering work deserves.

  11. Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of photograph, Joseph Yolo, photographer, 1936 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "WAHT A GOVERNMENT CANAL AND AN ASSURED WATER SUPPLY WILL DO IN A DESERT AREA IS SHOWN IN THIS AIR VIEW OF A SECTION OF THE YAKIMA FEDERAL RECLAMATION PROJECT IN CENTRAL WASHINGTON. THE MAIN CANAL IS SEEN RUNNING DOWN THE MIDDLE OF THE VALLEY WITH PATCHES OF ORCHARDS AND FIELDS ON EITHER SIDE, BUT ABOVE THE CANAL LINE THE SAGE BRUSH DESERT REMAINS, AS CAN BE SEEN ON THE LEFT. THE YAKIMA PROJECT SUPPORTS MORE THAN 110,000 PEOPLE IN A TERRITORY WHICH WAS DESERT 35 YEARS AGO. MANY OF THE ORIGINAL SETTLERS WHO CAME, LIKE THOSE WHO ARE NOW SETTLING ON THE VALE PROJECT, TO BREAK THE RAW DESERT LAND, ARE STILL LIVING ON THESE NEATLY CHECKERBOARDED FARMS" - Kachess Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

  12. Astronaut Joseph Tanner is assisted into his EMU during training

    NASA Image and Video Library

    1994-08-01

    S94-40048 (1 August 1994) --- Astronaut Joseph R. Tanner, mission specialist, is assisted by Boeing suit expert Steve Voyles as he prepares to be submerged in a 25-feet deep pool at the Johnson Space Center's (JSC) Weightless Environment Training Facility (WET-F). Though no extravehicular activity (EVA) is planned for the mission, at least two astronauts are trained to perform tasks that would require a space walk in the event of failure of remote systems. In November, Tanner will join four other NASA astronauts and a European mission specialist for a week and a half in space aboard the Space Shuttle Atlantis. The flight will support the Atmospheric Laboratory for Applications and Science (ATLAS-3) mission.

  13. Joseph Rotblat and the moral responsibilities of the scientist.

    PubMed

    Underwood, Martin Clifford

    2009-06-01

    Professor Sir Joseph Rotblat was one of the most distinguished scientists and peace campaigners of the post second world war period. He made significant contributions to nuclear physics and worked on the development of the atomic bomb. He then became one of the world's leading researchers into the biological effects of radiation. His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and peace. For this he was awarded the Nobel Peace Prize, together with Pugwash Conferences on Science and World Affairs (that he helped found) in 1995. His work in this area ranked with that of Albert Einstein and Bertrand Russell and this article is an attempt to summarise his life, achievements, but in particular outline his views on the moral responsibilities of the scientist. He is a towering intellectual figure and his contributions to mankind should be better known and more widely understood.

  14. Science Advisor and Applied Physicist: Joseph Henry Serves His Country

    NASA Astrophysics Data System (ADS)

    Rothenberg, Marc

    1997-04-01

    When Joseph Henry accepted the postion of secretary of the Smithsonian in 1846, his career changed radically. Although he never ceased thinking of himself as a research scientist and educator, thereafter his chief roles were those of science administrator and advisor to both the executive and legislative branches of the federal government for both science and technology. His effectiveness as an advocate became more important than his skill as an experimental physicist. Even when he entered the laboratory, his role had changed. No longer was he concerned with basic research. As a member of various government boards and committees, Henry spent the last three decades of his life concerned with the application of fundamental knowledge for the improvement of the human condition. This paper will discuss Henry's service on behalf of his country.

  15. Pierre-Joseph Macquer: Chemistry in the French Enlightenment.

    PubMed

    Lehman, Christine

    2014-01-01

    Despite recent studies of chemistry courses and of academic research at the beginning of the eighteenth century, the perception of chemistry in the French Enlightenment has often been overshadowed by Lavoisier's works. This article proposes three specific case studies selected from Pierre Joseph Macquer's (1718-84) rich career to show the continuous evolution of chemistry throughout the century: medicinal chemistry through the application of the Comte de La Garaye's metallic salt solutions, the emergence of industrial chemistry through a few of Macquer's evaluations at the Bureau du Commerce, and finally communal academic research through the experiments on diamonds using Tschirnhaus's lens. These examples attempt to illustrate the innovative, creative, dynamic, multicultural, and multifaceted chemistry of the Enlightenment.

  16. Joseph Lister: his contributions to early experimental physiology

    PubMed Central

    Howard, Edward R.

    2013-01-01

    Joseph Lister (1827–1912) acquired a lifelong interest in histology and experimental physiology while a student at University College London between 1848 and 1852. His first two publications in 1853 were histological studies of the contractile tissue of the iris and the skin. Studies of inflammation in 1855 progressed to experiments on the nervous control of arteries, using techniques of peripheral nerve division, spinal cord section and needle stimulation of the brain. This interest in nervous mechanisms led to innovative experiments on gut motility and the autonomic nervous system, from which he inferred that sympathetic nerve control was mediated via intrinsic neuronal plexuses in the gut wall, a mode of action confirmed 100 years later, in 1964–65. It is not generally known that Lister was elected FRS for this early experimental work and that his early commitment to experimental science and microscopy was the background to his later work on the development of surgical antisepsis.

  17. Joseph Lister and the performance of antiseptic surgery

    PubMed Central

    Worboys, Michael

    2013-01-01

    This article highlights a neglected feature of Joseph Lister's work, namely how, in addition to promoting germ theories and the principles of the antiseptic system, he also devoted much time and effort to communicating the performative aspects of antisepsis and of the many other surgical innovations that he developed. Attention to ‘detail’ and striving for ‘improvement’ were crucial to Listerian practice, and he sought to convey his credo in three main ways: first, his publications aimed at ‘bringing the subject out in the same sort of way as it had been worked out by himself’; second, he set out strict protocols and information on materials and methods, yet also encouraged surgeons to improvise; and third, he made himself an exemplar of a new form of professionalism, which made constancy and vigilance in practice a moral duty for surgeons. PMID:24686323

  18. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    NASA Astrophysics Data System (ADS)

    Matthews, Michael R.

    2009-06-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of photosynthesis (or the ‘restoration of air’ as it was called at the time); finally the paper indicates ways in which Priestley’s work on photosynthesis can be utilised in the school classroom to advance the understanding of scientific subject matter, to promote an understanding of the nature of scientific procedure and methodology, and finally to evaluate some basic tenets of the European Enlightenment that Priestley so passionately advocated.

  19. Sister Mary Joseph's nodule as initial pancreatic cancer manifestation.

    PubMed

    Vallejo Bernad, Cristina; Casamayor Franco, María Carmen; Hakim Alonso, Sofía

    2017-02-01

    We report the case of an 85-year-old female patient who presented with umbilical pain associated with an indurated growth, the whole being apparently consistent with incarcerated umbilical hernia, which prompted an urgent surgical procedure for its removal. The pathology study revealed dermal infiltration by a malignancy. Gland tumor cells expressed an immunohistochemical profile initially consistent with a pancreatic origin. In view of these findings a CT scan was performed, which revealed a pancreatic tail tumor as well as multiple hepatic metastasis. Skin metastasis is a rare sign usually reflecting a carcinoma of unknown origin. Umbilical skin metastasis, called Sister Mary Joseph´s nodule, reflect an intra-abdominal tumor, being pancreatic cancer strange.

  20. REACTOR COOLING

    DOEpatents

    Quackenbush, C.F.

    1959-09-29

    A nuclear reactor with provisions for selectively cooling the fuel elements is described. The reactor has a plurality of tubes extending throughout. Cylindrical fuel elements are disposed within the tubes and the coolant flows through the tubes and around the fuel elements. The fuel elements within the central portion of the reactor are provided with roughened surfaces of material. The fuel elements in the end portions of the tubes within the reactor are provlded with low conduction jackets and the fuel elements in the region between the central portion and the end portions are provided with smooth surfaces of high heat conduction material.

  1. Determination of kinetic parameters in the biosorption of Cr (VI) on immobilized Bacillus cereus M(1)(16) in a continuous packed bed column reactor.

    PubMed

    Maiti, Soumen K; Bera, Debabrata; Chattopadhyay, Parimal; Ray, Lalitagauri

    2009-11-01

    Due to technological advancement, environment suffers from untreated toxic heavy metal bearing effluent coming from different industries. Chromium (VI) is one of those heavy metals having adverse impact on ecological balance, human, and plant health because of its carcinogenic properties. Biosorption is presented as an alternative to traditional technologies which are costly and inefficient for treatment of industrial wastes containing low amount of heavy metals. In this study, bioremediation of Cr (VI) ions by immobilized Bacillus cereus M(1) (16) was investigated in a laboratory scale packed bed up-flow column reactor. The effect of important parameters, such as the inlet flow rate, influent concentration, and effective bed height, has been studied. External mass transfer, surface adsorption, and intrabead mass transfer were also studied to conclude the rate limiting step for removal of Cr (VI) and to determine the process parameters which are important for biosorption optimization. The external mass transfer coefficient was calculated at different flow rates (6.51 x 10(-2) to 7.58 x 10(-2) cm/min). Using the model, the surface adsorption rate constant (k(ad)) and the intrabead mass transfer coefficient (k (i)) were predicted as 0.0267 x 10(-3) and 0.7465 x 10(-3) l/g/min, respectively. Both are much lower than the external mass transfer coefficient (k(e)). The surface adsorption phenomenon is acting as the rate-limiting step due to its high resistance for removal of Cr (VI).

  2. High-Throughput Synthesis of Lignin Particles (∼30 nm to ∼2 μm) via Aerosol Flow Reactor: Size Fractionation and Utilization in Pickering Emulsions.

    PubMed

    Ago, Mariko; Huan, Siqi; Borghei, Maryam; Raula, Janne; Kauppinen, Esko I; Rojas, Orlando J

    2016-09-07

    An aerosol flow reactor was used for the first time for high-throughput, high yield synthesis of spherical lignin particles with given inherent hydrophilicity, depending on the precursor biomolecule. In situ fractionation via Berner type impactor afforded populations with characteristic sizes ranging from ∼30 nm to 2 μm. The as-produced, dry lignin particles displayed excellent mechanical integrity, even after redispersion under high shear in either mineral oil or water. They were effective in the stabilization of oil-in-water (O/W) Pickering emulsions with tunable droplet size, depending on the dimension of the lignin particles used for emulsification. The emulsion stability correlated with particle concentration as well as the respective lignin type. For the O/W emulsions stabilized with the more hydrophilic lignin particles, negligible changes in phase separation via Ostwald ripening and coalescence were observed over a period of time of more than two months. Together with the fact that the lignin particle concentrations used in emulsification were as low as 0.1%, our results reveal a remarkable ability to endow emulsified systems with high colloidal stability. Overall, we offer a new, high-yield, scalable nanomanufacturing approach to producing dry spherical lignin particles with size control and high production capacity. A number of emerging applications for these organic particles can be envisioned and, as a proof-of-concept, we illustrate here surfactant-free emulsification.

  3. NEUTRONIC REACTOR

    DOEpatents

    Wigner, E.P.

    1958-04-22

    A nuclear reactor for isotope production is described. This reactor is designed to provide a maximum thermal neutron flux in a region adjacent to the periphery of the reactor rather than in the center of the reactor. The core of the reactor is generally centrally located with respect tn a surrounding first reflector, constructed of beryllium. The beryllium reflector is surrounded by a second reflector, constructed of graphite, which, in tune, is surrounded by a conventional thermal shield. Water is circulated through the core and the reflector and functions both as a moderator and a coolant. In order to produce a greatsr maximum thermal neutron flux adjacent to the periphery of the reactor rather than in the core, the reactor is designed so tbat the ratio of neutron scattering cross section to neutron absorption cross section averaged over all of the materials in the reflector is approximately twice the ratio of neutron scattering cross section to neutron absorption cross section averaged over all of the material of the core of the reactor.

  4. Reactor building

    SciTech Connect

    Hista, J. C.

    1984-09-18

    Reactor building comprising a vessel shaft anchored in a slab which is peripherally locked. This reactor building comprises a confinement enclosure within which are positioned internal structures constituted by an internal structure floor, a vessel shaft, a slab being positioned between the general floor and the internal structure floor, the vesse

  5. NEUTRONIC REACTOR

    DOEpatents

    Metcalf, H.E.; Johnson, H.W.

    1961-04-01

    BS>A nuclear reactor incorporating fuel rods passing through a moderator and including tubes of a material of higher Thermal conductivity than the fuel in contact with the fuel is described. The tubes extend beyond the active portion of the reactor into contant with a fiuld coolant.

  6. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    SciTech Connect

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  7. STS-51A mission specialist Joseph P. Allen during WETF training

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Portrait view of STS-51A mission specialist Joseph P. Allen during training in the Weightless Environment Training Facility (WETF). He is wearing the extravehicular mobility unit (EMU) minus the helmet.

  8. Mission Specialst Joseph P. Allen ready for launch of STS-5

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Mission Specialst Joseph P. Allen, fully suited in his Shuttle constant wear garment and 'wired' for monitoring (note sensors on face and head), seems ready for launch in his seat in the middeck area of the Space Shuttle Columbia.

  9. 1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Joseph Hill, Photographer August 10th, 1936 (Copied from small photo taken by survey members) OLD APARTMENT HOUSE - Jansonist Colony, Old Apartment House, Main Street, Bishop Hill, Henry County, IL

  10. Compact Reactor

    NASA Astrophysics Data System (ADS)

    Williams, Pharis E.

    2007-01-01

    Weyl's Gauge Principle of 1929 has been used to establish Weyl's Quantum Principle (WQP) that requires that the Weyl scale factor should be unity. It has been shown that the WQP requires the following: quantum mechanics must be used to determine system states; the electrostatic potential must be non-singular and quantified; interactions between particles with different electric charges (i.e. electron and proton) do not obey Newton's Third Law at sub-nuclear separations, and nuclear particles may be much different than expected using the standard model. The above WQP requirements lead to a potential fusion reactor wherein deuterium nuclei are preferentially fused into helium nuclei. Because the deuterium nuclei are preferentially fused into helium nuclei at temperatures and energies lower than specified by the standard model there is no harmful radiation as a byproduct of this fusion process. Therefore, a reactor using this reaction does not need any shielding to contain such radiation. The energy released from each reaction and the absence of shielding makes the deuterium-plus-deuterium-to-helium (DDH) reactor very compact when compared to other reactors, both fission and fusion types. Moreover, the potential energy output per reactor weight and the absence of harmful radiation makes the DDH reactor an ideal candidate for space power. The logic is summarized by which the WQP requires the above conditions that make the prediction of DDH possible. The details of the DDH reaction will be presented along with the specifics of why the DDH reactor may be made to cause two deuterium nuclei to preferentially fuse to a helium nucleus. The presentation will also indicate the calculations needed to predict the reactor temperature as a function of fuel loading, reactor size, and desired output and will include the progress achieved to date.

  11. Compact Reactor

    SciTech Connect

    Williams, Pharis E.

    2007-01-30

    Weyl's Gauge Principle of 1929 has been used to establish Weyl's Quantum Principle (WQP) that requires that the Weyl scale factor should be unity. It has been shown that the WQP requires the following: quantum mechanics must be used to determine system states; the electrostatic potential must be non-singular and quantified; interactions between particles with different electric charges (i.e. electron and proton) do not obey Newton's Third Law at sub-nuclear separations, and nuclear particles may be much different than expected using the standard model. The above WQP requirements lead to a potential fusion reactor wherein deuterium nuclei are preferentially fused into helium nuclei. Because the deuterium nuclei are preferentially fused into helium nuclei at temperatures and energies lower than specified by the standard model there is no harmful radiation as a byproduct of this fusion process. Therefore, a reactor using this reaction does not need any shielding to contain such radiation. The energy released from each reaction and the absence of shielding makes the deuterium-plus-deuterium-to-helium (DDH) reactor very compact when compared to other reactors, both fission and fusion types. Moreover, the potential energy output per reactor weight and the absence of harmful radiation makes the DDH reactor an ideal candidate for space power. The logic is summarized by which the WQP requires the above conditions that make the prediction of DDH possible. The details of the DDH reaction will be presented along with the specifics of why the DDH reactor may be made to cause two deuterium nuclei to preferentially fuse to a helium nucleus. The presentation will also indicate the calculations needed to predict the reactor temperature as a function of fuel loading, reactor size, and desired output and will include the progress achieved to date.

  12. Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR)

    SciTech Connect

    A. Joseph Palmer; Gerry L. McCormick; Shannon J. Corrigan

    2010-06-01

    2010 International Congress on Advances in Nuclear Power Plants (ICAPP’10) ANS Annual Meeting Imbedded Topical San Diego, CA June 13 – 17, 2010 Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR) Author: A. Joseph Palmer, Mechanical Engineer, Irradiation Test Programs, 208-526-8700, Joe.Palmer@INL.gov Affiliation: Idaho National Laboratory P.O. Box 1625, MS-3840 Idaho Falls, ID 83415 INL/CON-10-17680 ABSTRACT Most test reactors are equipped with shuttle facilities (sometimes called rabbit tubes) whereby small capsules can be inserted into the reactor and retrieved during power operations. With the installation of Hydraulic Shuttle Irradiation System (HSIS) this capability has been restored to the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). The general design and operating principles of this system were patterned after the hydraulic rabbit at Oak Ridge National Laboratory’s (ORNL) High Flux Isotope Reactor (HFIR), which has operated successfully for many years. Using primary coolant as the motive medium the HSIS system is designed to simultaneously transport fourteen shuttle capsules, each 16 mm OD x 57 mm long, to and from the B-7 position of the reactor. The B-7 position is one of the higher flux positions in the reactor with typical thermal and fast (>1 Mev) fluxes of 2.8E+14 n/cm2/sec and 1.9E+14 n/cm2/sec respectively. The available space inside each shuttle is approximately 14 mm diameter x 50 mm long. The shuttle containers are made from titanium which was selected for its low neutron activation properties and durability. Shuttles can be irradiated for time periods ranging from a few minutes to several months. The Send and Receive Station (SRS) for the HSIS is located 2.5 m deep in the ATR canal which allows irradiated shuttles to be easily moved from the SRS to a wet loaded cask, or transport pig. The HSIS system first irradiated (empty) shuttles in September 2009 and has since completed

  13. NUCLEAR REACTOR

    DOEpatents

    Moore, R.V.; Bowen, J.H.; Dent, K.H.

    1958-12-01

    A heterogeneous, natural uranium fueled, solid moderated, gas cooled reactor is described, in which the fuel elements are in the form of elongated rods and are dlsposed within vertical coolant channels ln the moderator symmetrically arranged as a regular lattice in groups. This reactor employs control rods which operate in vertical channels in the moderator so that each control rod is centered in one of the fuel element groups. The reactor is enclosed in a pressure vessel which ls provided with access holes at the top to facilitate loading and unloadlng of the fuel elements, control rods and control rod driving devices.

  14. Flattened facial colliculus on magnetic resonance imaging in Machado-Joseph disease.

    PubMed

    Ogawa, Yoshitsugu; Ito, Shoichi; Makino, Takahiro; Kanai, Kazuaki; Arai, Kimihito; Kuwabara, Satoshi

    2012-07-01

    Atrophy of the pontine tegmentum and facial colliculus is a characteristic pathological feature of Machado-Joseph disease. We assessed whether this finding can be detected by conventional brain magnetic resonance imaging. A total of 17 patients with genetically confirmed Machado-Joseph disease, 15 disease controls (spinocerebellar ataxia type 6 and dentatorubral-pallidoluysian atrophy), and 17 normal subjects were examined using a 1.5-Tesla magnetic resonance imaging scanner. The widths of the facial colliculus, pontine tegmentum, and pontine base and the area of the fourth ventricle were measured on axial T2-weighted imaging. Pathological examination was performed in 9 Machado-Joseph disease patients. In addition, visual inspection of the facial colliculus was evaluated by receiver operating characteristic analysis. The width of the facial colliculus was significantly smaller in Machado-Joseph disease patients (0.37 ± 0.16 mm; mean ± standard deviation) than in normal subjects (0.73 ± 0.30 mm; P < .01), whereas the width of the pontine tegmentum was smaller in both Machado-Joseph disease (4.85 ± 0.58 mm) and dentatorubral-pallidoluysian atrophy (4.72 ± 0.59) patients than in normal subjects (6.35 ± 0.74 mm; P < .01). Visual evaluation of the facial colliculus showed sufficient area under the receiver operating characteristic curves to differentiate Machado-Joseph disease from dentatorubral-pallidoluysian atrophy (0.78) and spinocerebellar ataxia type 6 (0.87). Pathological evaluation showed significant atrophy of the facial colliculus in all Machado-Joseph disease patients. Atrophy of the facial colliculus is a feasible magnetic resonance imaging finding for diagnosing Machado-Joseph disease, and it is easily found as a flattening of the fourth ventricular floor. Copyright © 2012 Movement Disorder Society.

  15. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.

    PubMed

    Kanai, Kazuaki; Kuwabara, Satoshi; Arai, Kimihito; Sung, Jia-Ying; Ogawara, Kazue; Hattori, Takamichi

    2003-04-01

    Machado-Joseph disease is one of the most common hereditary spinocerebellar degenerative disorders with a wide range of clinical manifestations. Pathology studies have shown mild to moderate loss of anterior horn cells and, in terms of spinal pathology, Machado-Joseph disease is regarded as a type of lower motoneuron disease. Muscle cramps are often associated with lower motoneuron disorders, but features of cramps in Machado-Joseph disease patients have never been studied. We investigated the incidence and nature of muscle cramps in Machado-Joseph disease patients, the excitability properties of motor axons [strength-duration time constant (tau(SD)), threshold electrotonus, refractoriness and supernormality] using threshold tracking and the effects of mexiletine hydrochloride on those cramps. Of 20 consecutive patients, 16 (80%) had frequent, severe muscle cramps in the legs, trunk or arms that disturbed their daily activities. The frequency of pathological muscle cramps was similar to that for patients with amyotrophic lateral sclerosis (68%) and higher than those for patients with spinal muscular atrophy (33%) or peripheral axonal neuropathy (24%). Threshold-tracking studies showed that tau(SD), which in part reflects Na(+) conductance at the resting membrane potential, was significantly greater in the Machado-Joseph disease patients than in normal subjects; severe muscle cramps were associated with a longer tau(SD). Threshold electrotonus, refractoriness and supernormality were not significantly different between Machado-Joseph disease patients and normal subjects. Eight Machado-Joseph disease patients with severe cramps, who received mexiletine treatment, experienced nearly complete relief with a partial normalization of tau(SD) (P = 0.08). Muscle cramps are a very frequent and disabling factor in Machado-Joseph disease. Pathological muscle cramps responded well to mexiletine treatment, and this is consistent with the hypothesis that they are caused by an

  16. Neurophysiological studies and non-motor symptoms prior to ataxia in a patient with machado-joseph disease: trying to understand the natural history of brain degeneration.

    PubMed

    Pedroso, José Luiz; Bor-Seng-Shu, Edson; Braga-Neto, Pedro; Ribeiro, Rodrigo Souza; Bezerra, Márcio Luiz Escorcio; do Prado, Lucila B F; Batista, Ilza Rosa; Alessi, Helena; Teixeira, Manoel Jacobsen; Manzano, Gilberto Mastrocola; do Prado, Gilmar Fernandes; Barsottini, Orlando Graziani Povoas

    2014-08-01

    Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia. In this neurological disease, anatomical, physiological, clinical, and functional neuroimaging demonstrate a degenerative process besides the cerebellum. We performed neurophysiological and neuroimaging studies-polysomnography, transcranial sonography, vestibular-evoked myogenic potential, single-photon emission computed tomography (SPECT) with (99m)Tc-TRODAT-1, and a formal neuropsychological evaluation in a patient with sleep complaints and positive testing for Machado-Joseph disease, without cerebellar atrophy, ataxia, or cognitive complaints. Polysomnography disclosed paradoxical high amplitude of submental muscle, characterizing REM sleep without atonia phenomenon. Transcranial sonography showed hyperechogenicity of the substantia nigra. There was an absence of vestibular-evoked myogenic potentials on both sides in the patient under study, in opposite to 20 healthy subjects. Brain imaging SPECT with (99m)Tc-TRODAT-1 demonstrated a significant lower DAT density than the average observed in six healthy controls. Electroneuromyography was normal. Neuropsychological evaluation demonstrated visuospatial and memory deficits. Impairment of midbrain cholinergic and pontine noradrenergic systems, dysfunction of the pre-synaptic nigrostriatal system, changes in echogenicity of the substantia nigra, and damage to vestibulo-cervical pathways are supposed to occur previous to cerebellar involvement in Machado-Joseph disease.

  17. NEUTRONIC REACTOR

    DOEpatents

    Fermi, E.

    1960-04-01

    A nuclear reactor is described consisting of blocks of graphite arranged in layers, natural uranium bodies disposed in holes in alternate layers of graphite blocks, and coolant tubes disposed in the layers of graphite blocks which do not contain uranium.

  18. NEUTRONIC REACTORS

    DOEpatents

    Wigner, E.P.

    1960-11-22

    A nuclear reactor is described wherein horizontal rods of thermal- neutron-fissionable material are disposed in a body of heavy water and extend through and are supported by spaced parallel walls of graphite.

  19. NEUTRONIC REACTOR

    DOEpatents

    Anderson, H.L.

    1960-09-20

    A nuclear reactor is described comprising fissionable material dispersed in graphite blocks, helium filling the voids of the blocks and the spaces therebetween, and means other than the helium in thermal conductive contact with the graphite for removing heat.

  20. Reactor apparatus

    DOEpatents

    Echtler, J. Paul

    1981-01-01

    A reactor apparatus for hydrocracking a polynuclear aromatic hydrocarbonaceous feedstock to produce lighter hydrocarbon fuels by contacting the hydrocarbonaceous feedstock with hydrogen in the presence of a molten metal halide catalyst.

  1. Chemical Reactors.

    ERIC Educational Resources Information Center

    Kenney, C. N.

    1980-01-01

    Describes a course, including content, reading list, and presentation on chemical reactors at Cambridge University, England. A brief comparison of chemical engineering education between the United States and England is also given. (JN)

  2. NEUTRONIC REACTOR

    DOEpatents

    Hurwitz, H. Jr.; Brooks, H.; Mannal, C.; Payne, J.H.; Luebke, E.A.

    1959-03-24

    A reactor of the heterogeneous, liquid cooled type is described. This reactor is comprised of a central region of a plurality of vertically disposed elongated tubes surrounded by a region of moderator material. The central region is comprised of a central core surrounded by a reflector region which is surrounded by a fast neutron absorber region, which in turn is surrounded by a slow neutron absorber region. Liquid sodium is used as the primary coolant and circulates through the core which contains the fuel elements. Control of the reactor is accomplished by varying the ability of the reflector region to reflect neutrons back into the core of the reactor. For this purpose the reflector is comprised of moderator and control elements having varying effects on reactivity, the control elements being arranged and actuated by groups to give regulation, shim, and safety control.

  3. Reactor Engineering

    NASA Astrophysics Data System (ADS)

    Lema, Juan M.; López, Carmen; Eibes, Gemma; Taboada-Puig, Roberto; Moreira, M. Teresa; Feijoo, Gumersindo

    In this chapter, the engineering aspects of processes catalyzed by peroxidases will be presented. In particular, a discussion of the existing technologies that utilize peroxidases for different purposes, such as the removal of recalcitrant compounds or the synthesis of polymers, is analyzed. In the first section, the essential variables controlling the process will be investigated, not only those that are common in any enzymatic system but also those specific to peroxidative reactions. Next, different reactor configurations and operational modes will be proposed, emphasizing their suitability and unsuitability for different systems. Finally, two specific reactors will be described in detail: enzymatic membrane reactors and biphasic reactors. These configurations are especially valuable for the treatment of xenobiotics with high and poor water solubility, respectively.

  4. NUCLEAR REACTOR

    DOEpatents

    Miller, H.I.; Smith, R.C.

    1958-01-21

    This patent relates to nuclear reactors of the type which use a liquid fuel, such as a solution of uranyl sulfate in ordinary water which acts as the moderator. The reactor is comprised of a spherical vessel having a diameter of about 12 inches substantially surrounded by a reflector of beryllium oxide. Conventionnl control rods and safety rods are operated in slots in the reflector outside the vessel to control the operation of the reactor. An additional means for increasing the safety factor of the reactor by raising the ratio of delayed neutrons to prompt neutrons, is provided and consists of a soluble sulfate salt of beryllium dissolved in the liquid fuel in the proper proportion to obtain the result desired.

  5. NUCLEAR REACTOR

    DOEpatents

    Sherman, J.; Sharbaugh, J.E.; Fauth, W.L. Jr.; Palladino, N.J.; DeHuff, P.G.

    1962-10-23

    A nuclear reactor incorporating seed and blanket assemblies is designed. Means are provided for obtaining samples of the coolant from the blanket assemblies and for varying the flow of coolant through the blanket assemblies. (AEC)

  6. REACTOR SHIELD

    DOEpatents

    Wigner, E.P.; Ohlinger, L.E.; Young, G.J.; Weinberg, A.M.

    1959-02-17

    Radiation shield construction is described for a nuclear reactor. The shield is comprised of a plurality of steel plates arranged in parallel spaced relationship within a peripheral shell. Reactor coolant inlet tubes extend at right angles through the plates and baffles are arranged between the plates at right angles thereto and extend between the tubes to create a series of zigzag channels between the plates for the circulation of coolant fluid through the shield. The shield may be divided into two main sections; an inner section adjacent the reactor container and an outer section spaced therefrom. Coolant through the first section may be circulated at a faster rate than coolant circulated through the outer section since the area closest to the reactor container is at a higher temperature and is more radioactive. The two sections may have separate cooling systems to prevent the coolant in the outer section from mixing with the more contaminated coolant in the inner section.

  7. Strabismus and Micro-Opsoclonus in Machado-Joseph Disease.

    PubMed

    Ghasia, Fatema F; Wilmot, George; Ahmed, Anwar; Shaikh, Aasef G

    2016-08-01

    We describe novel deficits of gaze holding and ocular alignment in patients with spinocerebellar ataxia type 3, also known as Machado-Joseph disease (MJD). Twelve MJD patients were studied. Clinical assessments and quantitative ocular alignment measures were performed. Eye movements were quantitatively assessed with corneal curvature tracker and video-oculography. Strabismus was seen in ten MJD patients. Four patients had mild to moderate intermittent exotropia, three had esotropia, one had skew deviation, one had hypotropia, and one patient had moderate exophoria. Three strabismic patients had V-pattern. Near point of convergence was normal in two out of three patients with exotropia. Gaze holding deficits were also common. Eight patients had gaze-evoked nystagmus, and five had micro-opsoclonus. Other ocular motor deficits included saccadic dysmetria in eight patients, whereas all had saccadic interruption of smooth pursuit. Strabismus and micro-opsoclonus are common in MJD. Coexisting ophthalmoplegia or vergence abnormalities in our patients with exotropia that comprised 50 % of the cohort could not explain the type of strabismus in our patients. Therefore, it is possible that involvement of the brainstem, the deep cerebellar nuclei, and the superior cerebellar peduncle are the physiological basis for exotropia in these patients. Micro-opsoclonus was also common in MJD. Brainstem and deep cerebellar nuclei lesion also explains micro-opsoclonus, whereas brainstem deficits can describe slow saccades seen in our patients with MJD.

  8. Executive and emotional dysfunction in Machado-Joseph disease.

    PubMed

    Zawacki, Tricia M; Grace, Janet; Friedman, Joseph H; Sudarsky, Lewis

    2002-09-01

    Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia. Few studies have examined the neuropsychological and neurobehavioral profiles of patients with MJD. In this study, six individuals with MJD were given a battery of neuropsychological tests. Relative impairments on timed verbal attention tasks and verbal fluency (Stroop, Oral Symbol Digit Modalities, and Controlled Oral Word Association Test) were found. Other executive impairments also were seen on the Wisconsin Card Sorting Test, independent of motor dysfunction severity. Moderate- to severe levels of depressive symptoms were endorsed by four of the six patients, and caregivers observed increased apathy in the patients. Impaired executive and emotional functioning in MJD does not appear to be related to ataxia severity. These patients did not meet the criteria for dementia. General cognitive abilities, language, list learning, story recall, and untimed tasks of attention were within normal limits. Impaired executive abilities and emotional functioning in MJD patients is consistent with disruption of frontal-subcortical systems. Copyright 2002 Movement Disorder Society.

  9. Joseph Carpue's file drawer experiment - A murder mystery from 1801.

    PubMed

    Freshwater, M Felix

    2015-12-01

    Today unpublished or "file drawer" experiments are the impetus for trial registration and reporting of all results. In 1801, Joseph Carpue, the father of modern plastic surgery, did a file drawer experiment for Benjamin West, who was President of the Royal Academy of Arts. George III had commissioned West to create the largest stained glass window ever created whose theme, the Crucifixion, was based upon Michelangelo's drawing. Subsequently, West suffered a series of political, professional and economic setbacks. In the summer of 1801, West's project was delayed. By the fall, West hoped that independent scientific confirmation of his design could salvage the project. West approached Carpue who obtained a murderer's fresh corpse that he crucified and documented the results with plaster casts created by sculptor Thomas Banks. Carpue's experiment showed that West's window design wrongly depicted the Crucifixion because West had posed the hands and shoulders incorrectly. West died in 1820 without ever being associated with Carpue's experiment. Carpue's obituary in The Lancet in 1846 contained Carpue's handwritten note that described the experiment but not West's Royal commission. As no records or publications associate the cast with West project, this can be considered to be a file drawer experiment. After 1801, West made further drawings of the Crucifixion that showed the figures in the same position as the cast. Nineteenth century auction catalogues suggest that West made a corrected Crucifixion painting, but its current location remains a mystery.

  10. Profile: Joseph Marek: 2016-17 ASCP President.

    PubMed

    Bloom, Marlene Z

    It was four months in Alaska, in the middle of winter, that changed Joseph Marek's view of what it means to be a pharmacist. Marek was on his last rotation in pharmacy school when he experienced the kind of practice that he wanted for himself. He found that kind of practice as a consultant pharmacist, and next month, Marek, 49, will become the 2016-2017 president of the American Society of Consulting Pharmacists. Working at the Public Health Service (PHS) in the Arctic Circle in 1990, he dispensed and carried out clinical duties with the chief pharmacist and provided care to the native Inuit population through the Indian Health Service. "PHS had a walk-in clinic where the physicians worked closely with the pharmacist to do medication management for the patients," he said. The pharmacists also provided medications to the surrounding villages (50,000 square miles) and had to coordinate the dispensing/delivery of these medications when the physicians visited them. "The doctors highly valued the pharmacists' clinical knowledge, and it was a great environment to learn how to collaborate with the medical/health care team to benefit the Inuits," he said. "Everyone worked together and you could see the outcomes quickly."

  11. Electrical Enlightenment: Joseph Priestley's Historical and Experimental Studies of Electricity

    NASA Astrophysics Data System (ADS)

    Boantza, Victor

    Joseph Priestley (1733-1804) was one of the most controversial public figures of the eighteenth century. A true Enlightenment polymath, he wrote more than two hundred books, pamphlets, sermons, and essays on subjects ranging from science to politics and from metaphysics to theology. He was a religious dissenter, political radical, vocal supporter of the French Revolution, and lifelong defender of the losing side in the Chemical Revolution. Priestley is best known for having ``discovered'' oxygen in the 1770s and for his lasting contributions to pneumatic chemistry. Yet his first scientific fascination, while teaching at Warrington Academy, was electricity--one of the greatest scientific fads of the Enlightenment. Priestley's work on electricity, both historical and experimental, culminated in his History and Present State of Electricity (1767), which became a standard textbook on the subject for nearly a century, and went through numerous editions and translations. Situating Priestley's electrical investigations against the background of eighteenth-century ideals of scientific theory and practice, especially concerning physics, experimental philosophy, and natural history, illuminates the relations between science, society, and epistemology in the Enlightenment.

  12. Moths on the Flatbed Scanner: The Art of Joseph Scheer

    PubMed Central

    Buchmann, Stephen L.

    2011-01-01

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale. PMID:26467835

  13. The way of sex: Joseph Needham and Jolan Chang.

    PubMed

    Rocha, Leon Antonio

    2012-09-01

    This paper analyses the understandings of Daoist alchemy and Chinese sexuality of Joseph Needham and his friend and correspondent, the Chinese-Swedish writer Jolan Chang (Chang Chung-lan, 1917-2002). Using the extensive correspondence between the two men, as well as Needham's files on "inner alchemy" deposited at the Needham Research Institute, the paper begins with a partial reconstruction of a 1977 symposium, chaired by Needham, to promote Chang's new book, The Tao of Love and Sex: The Ancient Chinese Way to Ecstasy. Needham and Chang's visions of Chinese sex are then read against excerpts from Science and Civilisation in China, specifically Volume V: Chemistry and Chemical Technology, Part 5: Spagyrical Discovery and Invention: Physiological Alchemy (1983). Three inter-related aspects are explored. First, reading Science and Civilisation in China against materials in the Needham archives offers crucial hints to Needham's historiography and historical practice. Second, the way that Daoist regimens came to be actively reconstructed and repackaged as practices concerned with the enhancement of sexual pleasure and intensity. Third, the investigation of the networks and circulations of assumptions, visions, fantasies about "China". Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

    PubMed Central

    Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira

    2016-01-01

    Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the ATXN3 gene. This expansion translates into a polyglutamine tract within the ataxin-3 protein that confers a toxic gain-of-function to the mutant protein ataxin-3, contributing to protein misfolding and intracellular accumulation of aggregates and neuronal degeneration. Autophagy impairment has been shown to be one of the mechanisms that contribute for the MJD phenotype. Here we investigated whether this phenotype was present in patient-derived fibroblasts, a common somatic cell type used in the derivation of induced pluripotent stem cells and subsequent differentiation into neurons, for in vitro disease modeling. We generated and studied adult dermal fibroblasts from 5 MJD patients and 4 healthy individuals and we found that early passage MJD fibroblasts exhibited autophagy impairment with an underlying mechanism of decreased autophagosome production. The overexpression of beclin-1 on MJD fibroblasts reverted partially autophagy impairment by increasing the autophagic flux but failed to increase the levels of autophagosome production. Overall, our results provide a well-characterized MJD fibroblast resource for neurodegenerative disease research and contribute for the understanding of mutant ataxin-3 biology and its molecular consequences. PMID:27328712

  15. Franz Joseph Gall and music: the faculty and the bump.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking.

  16. NEUTRONIC REACTORS

    DOEpatents

    Vernon, H.C.

    1959-01-13

    A neutronic reactor of the heterogeneous, fluid cooled tvpe is described. The reactor is comprised of a pressure vessel containing the moderator and a plurality of vertically disposed channels extending in spaced relationship through the moderator. Fissionable fuel material is placed within the channels in spaced relationship thereto to permit circulation of the coolant fluid. Separate means are provided for cooling the moderator and for circulating a fluid coolant thru the channel elements to cool the fuel material.

  17. NUCLEAR REACTOR

    DOEpatents

    Anderson, C.R.

    1962-07-24

    A fluidized bed nuclear reactor and a method of operating such a reactor are described. In the design means are provided for flowing a liquid moderator upwardly through the center of a bed of pellets of a nentron-fissionable material at such a rate as to obtain particulate fluidization while constraining the lower pontion of the bed into a conical shape. A smooth circulation of particles rising in the center and falling at the outside of the bed is thereby established. (AEC)

  18. NUCLEAR REACTOR

    DOEpatents

    Breden, C.R.; Dietrich, J.R.

    1961-06-20

    A water-soluble non-volatile poison may be introduced into a reactor to nullify excess reactivity. The poison is removed by passing a side stream of the water containing the soluble poison to an evaporation chamber. The vapor phase is returned to the reactor to decrease the concentration of soluble poison and the liquid phase is returned to increase the concentration of soluble poison.

  19. Constraints on the Chief Joseph Dike Swarm of the Columbia River Flood Basalts from the legacy dataset of William H. Taubeneck

    NASA Astrophysics Data System (ADS)

    Nasholds, M. W.; Karlstrom, L.; Morriss, M. C.

    2016-12-01

    The Chief Joseph dike swarm, spanning northeastern OR, southeastern WA, and parts of western ID, is one of the primary dike swarms feeding the mid-Miocene Columbia River Basalt Group (CRBG) (e.g. Reidel et al. 2013). William H. Taubeneck (1923-2016) mapped these and other CRBG feeder dikes over 40 years, generating an expansive dataset with locations and characteristics of dike segments, primarily centered within the Wallowa Mountains, extending as far north as Lewiston, ID, and as far south as Farewell Bend, OR. Taubeneck is credited with originally defining the Chief Joseph swarm, but his data was not made available until his death. Using ArcMap, we are in the process of digitizing, field checking, and making available relevant data from Taubeneck's annotated maps and notebooks. We extract dike locations, orientations, thicknesses, and host rock characteristics. We present an overview of the Taubeneck data, relating to Chief Joseph dikes in WA, ID, and newer field measurements in the Wallowas, OR. Strikes of the 4410 dike segments range from NNW to NNE, with outliers that define smaller clusters with distinct orientations. The dikes have primarily near-vertical dips, paleo-depths ranging from 2 km to 0.3 km, and limited observations indicate widths from <5 m to 40 m. A majority of dikes are exposed in uplifted granites of the Wallowa batholith and metamorphosed host: 1606 dikes occur in quartz diorite, 60 occur in the Hurwal Formation, 139 occur in metavolcanics, while 401 occur in CRBG basalt. The other 2204 dikes are not in the Chief Joseph area. There does not seem to be a significant relation between host rock composition and dike orientation, although wall rock interactions are more dramatic in non-granitic Tertiary rocks. This dataset may provide further insight into both dike emplacement dynamics and the plumbing system of the CRBG.

  20. NUCLEAR REACTOR

    DOEpatents

    Grebe, J.J.

    1959-07-14

    High temperature reactors which are uniquely adapted to serve as the heat source for nuclear pcwered rockets are described. The reactor is comprised essentially of an outer tubular heat resistant casing which provides the main coolant passageway to and away from the reactor core within the casing and in which the working fluid is preferably hydrogen or helium gas which is permitted to vaporize from a liquid storage tank. The reactor core has a generally spherical shape formed entirely of an active material comprised of fissile material and a moderator material which serves as a diluent. The active material is fabricated as a gas permeable porous material and is interlaced in a random manner with very small inter-connecting bores or capillary tubes through which the coolant gas may flow. The entire reactor is divided into successive sections along the direction of the temperature gradient or coolant flow, each section utilizing materials of construction which are most advantageous from a nuclear standpoint and which at the same time can withstand the operating temperature of that particular zone. This design results in a nuclear reactor characterized simultaneously by a minimum critiral size and mass and by the ability to heat a working fluid to an extremely high temperature.

  1. Research reactors - an overview

    SciTech Connect

    West, C.D.

    1997-03-01

    A broad overview of different types of research and type reactors is provided in this paper. Reactor designs and operating conditions are briefly described for four reactors. The reactor types described include swimming pool reactors, the High Flux Isotope Reactor, the Mark I TRIGA reactor, and the Advanced Neutron Source reactor. Emphasis in the descriptions is placed on safety-related features of the reactors. 7 refs., 7 figs., 2 tabs.

  2. NEUTRONIC REACTOR

    DOEpatents

    Ohlinger, L.A.; Wigner, E.P.; Weinberg, A.M.; Young, G.J.

    1958-09-01

    This patent relates to neutronic reactors of the heterogeneous water cooled type, and in particular to a fuel element charging and discharging means therefor. In the embodiment illustrated the reactor contains horizontal, parallel coolant tubes in which the fuel elements are disposed. A loading cart containing a magnzine for holding a plurality of fuel elements operates along the face of the reactor at the inlet ends of the coolant tubes. The loading cart is equipped with a ram device for feeding fuel elements from the magazine through the inlot ends of the coolant tubes. Operating along the face adjacent the discharge ends of the tubes there is provided another cart means adapted to receive irradiated fuel elements as they are forced out of the discharge ends of the coolant tubes by the incoming new fuel elements. This cart is equipped with a tank coataining a coolant, such as water, into which the fuel elements fall, and a hydraulically operated plunger to hold the end of the fuel element being discharged. This inveation provides an apparatus whereby the fuel elements may be loaded into the reactor, irradiated therein, and unloaded from the reactor without stopping the fiow of the coolant and without danger to the operating personnel.

  3. Oral Histories in Meteoritics and Planetary Science - XVII: Joseph Goldstein

    NASA Astrophysics Data System (ADS)

    Sears, Derek W. G.

    2012-05-01

    In this interview, Joseph Goldstein (Fig. 1) recounts how he became interested in meteorites during his graduate studies working with Robert Ogilvie at MIT. By matching the Ni profiles observed across taenite fields in the Widmanstätten structure of iron meteorites with profiles he computed numerically he was able to determine cooling rates as the meteorites cooled through 650-400 °C. Upon graduating, he worked with a team of meteorite researchers led by Lou Walter at Goddard Space Flight Center where for 4 years he attempted to understand metallographic structures by reproducing them in the laboratory. Preferring an academic environment, Joe accepted a faculty position in the rapidly expanding metallurgy department at Lehigh University where he was responsible for their new electron microprobe. He soon became involved in studying the metal from lunar soils and identifying the metallic component from its characteristic iron and nickel compositions. Over the next two decades he refined these studies of Ni diffusion in iron meteorites, particularly the effect of phosphorus in the process, which resulted in superior Fe-Ni-P phase diagrams and improved cooling rates for the iron meteorites. After a period as vice president for research at Lehigh, in 1993 he moved to the University of Massachusetts to serve as dean of engineering, but during these administrative appointments Joe produced a steady stream of scientific results. Joe has served as Councilor, Treasurer, Vice President, and President of the Meteoritical Society. He received the Leonard Medal in 2005, the Sorby Award in 1999, and the Dumcumb Award for in 2008.

  4. Strong linkage disequilibrium and haplotype analysis in Japanese pedigrees with Machado-Joseph disease

    SciTech Connect

    Endo, Kotaro; Tanaka, Hajime; Saito, Masaaki

    1996-09-20

    To identify the markers tightly linked to Machado-Joseph disease (MJD) and to investigate whether a limited number of ancestral chromosomes are shared by Japanese MJD pedigrees, a detailed linkage analysis employing D14S55, D14S48, D14S67, D14S291, D14S280, AFM343vf1, D14S81, D14S265, D14S62, and D14S65 was performed. The results of multipoint linkage analysis as well as detection of critical recombination events indicate that the gene for MJD is localized in a 4-cM region between D14S280-D14S81. We found strong linkage disequilibria at AFM343vf1 and D14S81, and association of a few common haplotypes with MJD. These results indicate that there is an obvious founder effect in Japanese MJD and suggest the possibility of the existence of predisposing haplotypes which are prone to expansions of CAG repeats. 47 refs., 3 figs., 2 tabs.

  5. Machado-Joseph disease in Brazil: from the first descriptions to the emergence as the most common spinocerebellar ataxia.

    PubMed

    Pedroso, José Luiz; Braga-Neto, Pedro; Radvany, João; Barsottini, Orlando Graziani Povoas

    2012-08-01

    Machado-Joseph disease is an autosomal dominant inherited disorder of Azorean ancestry firstly described in 1972. Since then, several Brazilian researchers have studied clinical and genetic issues related to the disease. Nowadays, Machado-Joseph disease is considered the most common spinocerebellar ataxia worldwide. Machado-Joseph disease still has no specific therapy to arrest progression, but the unclear pathophysiological mechanism, features related to genetic characteristics, phenotype variability, apparently global involvement of the nervous system in the disease and the therapeutic challenges continue to attract investigators in the field of spinocerebellar ataxias. Brazilian researchers have distinguished themselves in the ongoing investigation seeking new knowledge about Machado-Joseph disease.

  6. EBT reactor analysis

    SciTech Connect

    Uckan, N. A.; Jaeger, E. F.; Santoro, R. T.; Spong, D. A.; Uckan, T.; Owen, L. W.; Barnes, J. M.; McBride, J. B.

    1983-08-01

    This report summarizes the results of a recent ELMO Bumpy Torus (EBT) reactor study that includes ring and core plasma properties with consistent treatment of coupled ring-core stability criteria and power balance requirements. The principal finding is that constraints imposed by these coupling and other physics and technology considerations permit a broad operating window for reactor design optimization. Within this operating window, physics and engineering systems analysis and cost sensitivity studies indicate that reactors with <..beta../sub core/> approx. 6 to 10%, P approx. 1200 to 1700 MW(e), wall loading approx. 1.0 to 2.5 MW/m/sup 2/, and recirculating power fraction (including ring-sustaining power and all other reactors auxiliaries) approx. 10 to 15% are possible. A number of concept improvements are also proposed that are found to offer the potential for further improvement of the reactor size and parameters. These include, but are not limited to, the use of: (1) supplementary coils or noncircular mirror coils to improve magnetic geometry and reduce size, (2) energetic ion rings to improve ring power requirements, (3) positive potential to enhance confinement and reduce size, and (4) profile control to improve stability and overall fusion power density.

  7. NUCLEAR REACTOR

    DOEpatents

    Christy, R.F.

    1958-07-15

    A nuclear reactor of the homogeneous liquid fuel type is described wherein the fissionable isotope is suspended or dissolved in a liquid moderator such as water. The reactor core is comprised essentially of a spherical vessel for containing the reactive composition surrounded by a reflector, preferably of beryllium oxide. The reactive composition may be an ordinary water solution of a soluble salt of uranium, the quantity of fissionable isotope in solution being sufficient to provide a critical mass in the vessel. The liquid fuel is stored in a tank of non-crtttcal geometry below the reactor vessel and outside of the reflector and is passed from the tank to the vessel through a pipe connecting the two by air pressure means. Neutron absorbing control and safety rods are operated within slots in the reflector adjacent to the vessel.

  8. NEUTRONIC REACTOR

    DOEpatents

    Metcalf, H.E.

    1957-10-01

    A reactor of the type which preferably uses plutonium as the fuel and a liquid moderator, preferably ordinary water, and which produces steam within the reactor core due to the heat of the chain reaction is described. In the reactor shown the fuel elements are essentially in the form of trays and are ventically stacked in spaced relationship. The water moderator is continuously supplied to the trays to maintain a constant level on the upper surfaces of the fuel element as it is continually evaporated by the heat. The steam passes out through the spaces between the fuel elements and is drawn off at the top of the core. The fuel elements are clad in aluminum to prevent deterioration thereof with consequent contamimation of the water.

  9. REACTOR CONTROL

    DOEpatents

    Fortescue, P.; Nicoll, D.

    1962-04-24

    A control system employed with a high pressure gas cooled reactor in which a control rod is positioned for upward and downward movement into the neutron field from a position beneath the reactor is described. The control rod is positioned by a coupled piston cylinder releasably coupled to a power drive means and the pressurized coolant is directed against the lower side of the piston. The coolant pressure is offset by a higher fiuid pressure applied to the upper surface of the piston and means are provided for releasing the higher pressure on the upper side of the piston so that the pressure of the coolant drives the piston upwardly, forcing the coupled control rod into the ncutron field of the reactor. (AEC)

  10. NEUTRONIC REACTORS

    DOEpatents

    Wigner, E.P.; Young, G.J.

    1958-10-14

    A method is presented for loading and unloading rod type fuel elements of a neutronic reactor of the heterogeneous, solld moderator, liquid cooled type. In the embodiment illustrated, the fuel rods are disposed in vertical coolant channels in the reactor core. The fuel rods are loaded and unloaded through the upper openings of the channels which are immersed in the coolant liquid, such as water. Unloading is accomplished by means of a coffer dam assembly having an outer sleeve which is placed in sealing relation around the upper opening. A radiation shield sleeve is disposed in and reciprocable through the coffer dam sleeve. A fuel rod engaging member operates through the axial bore in the radiation shield sleeve to withdraw the fuel rod from its position in the reactor coolant channel into the shield, the shield snd rod then being removed. Loading is accomplished in the reverse procedure.

  11. Bioconversion reactor

    DOEpatents

    McCarty, Perry L.; Bachmann, Andre

    1992-01-01

    A bioconversion reactor for the anaerobic fermentation of organic material. The bioconversion reactor comprises a shell enclosing a predetermined volume, an inlet port through which a liquid stream containing organic materials enters the shell, and an outlet port through which the stream exits the shell. A series of vertical and spaced-apart baffles are positioned within the shell to force the stream to flow under and over them as it passes from the inlet to the outlet port. The baffles present a barrier to the microorganisms within the shell causing them to rise and fall within the reactor but to move horizontally at a very slow rate. Treatment detention times of one day or less are possible.

  12. Catalytic reactor

    SciTech Connect

    Aaron, Timothy Mark; Shah, Minish Mahendra; Jibb, Richard John

    2009-03-10

    A catalytic reactor is provided with one or more reaction zones each formed of set(s) of reaction tubes containing a catalyst to promote chemical reaction within a feed stream. The reaction tubes are of helical configuration and are arranged in a substantially coaxial relationship to form a coil-like structure. Heat exchangers and steam generators can be formed by similar tube arrangements. In such manner, the reaction zone(s) and hence, the reactor is compact and the pressure drop through components is minimized. The resultant compact form has improved heat transfer characteristics and is far easier to thermally insulate than prior art compact reactor designs. Various chemical reactions are contemplated within such coil-like structures such that as steam methane reforming followed by water-gas shift. The coil-like structures can be housed within annular chambers of a cylindrical housing that also provide flow paths for various heat exchange fluids to heat and cool components.

  13. POWER REACTOR

    DOEpatents

    Zinn, W.H.

    1958-07-01

    A fast nuclear reactor system ls described for producing power and radioactive isotopes. The reactor core is of the heterogeneous, fluid sealed type comprised of vertically arranged elongated tubular fuel elements having vertical coolant passages. The active portion is surrounded by a neutron reflector and a shield. The system includes pumps and heat exchangers for the primary and secondary coolant circuits. The core, primary coolant pump and primary heat exchanger are disposed within an irapenforate tank which is filled with the primary coolant, in this case a liquid metal such as Na or NaK, to completely submerge these elements. The tank is completely surrounded by a thick walled concrete shield. This reactor system utilizes enriched uranium or plutonium as the fissionable material, uranium or thorium as a diluent and thorium or uranium containing less than 0 7% of the U/sup 235/ isotope as a fertile material.

  14. NEUTRONIC REACTOR

    DOEpatents

    Fermi, E.; Szilard, L.

    1957-09-24

    Reactors of the type employing plates of natural uranium in a moderator are discussed wherein the plates are um-formly disposed in parallel relationship to each other thereby separating the moderator material into distinct and individual layers. Each plate has an uninterrupted sunface area substantially equal to the cross-sectional area of the active portion of the reactor, the particular size of the plates and the volume ratio of moderator to uranium required to sustain a chain reaction being determinable from the known purity of these materials and other characteristics such as the predictable neutron losses due to the formation of radioactive elements of extremely high neutron capture cross section.

  15. NEUTRONIC REACTOR

    DOEpatents

    Wigner, E.P.; Weinberg, A.W.; Young, G.J.

    1958-04-15

    A nuclear reactor which uses uranium in the form of elongated tubes as fuel elements and liquid as a coolant is described. Elongated tubular uranium bodies are vertically disposed in an efficient neutron slowing agent, such as graphite, for example, to form a lattice structure which is disposed between upper and lower coolant tanks. Fluid coolant tubes extend through the uranium bodies and communicate with the upper and lower tanks and serve to convey the coolant through the uranium body. The reactor is also provided with means for circulating the cooling fluid through the coolant tanks and coolant tubes, suitable neutron and gnmma ray shields, and control means.

  16. Nonmotor and extracerebellar features in Machado-Joseph disease: a review.

    PubMed

    Pedroso, José Luiz; França, Marcondes C; Braga-Neto, Pedro; D'Abreu, Anelyssa; Saraiva-Pereira, Maria Luiza; Saute, Jonas A; Teive, Hélio A; Caramelli, Paulo; Jardim, Laura Bannach; Lopes-Cendes, Iscia; Barsottini, Orlando Graziani P

    2013-08-01

    Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia worldwide, and the high frequency of nonmotor manifestations in Machado-Joseph disease demonstrates how variable is the clinical expression of this single genetic entity. Anatomical, physiological, clinical, and functional neuroimaging data reinforce the idea of a degenerative process involving extracerebellar regions of the nervous system in Machado-Joseph disease. Brain imaging and neuropathologic studies have revealed atrophy of the pons, basal ganglia, midbrain, medulla oblongata, multiple cranial nerve nuclei, and thalamus and of the frontal, parietal, temporal, occipital, and limbic lobes. This review provides relevant information about nonmotor manifestations and extracerebellar symptoms in Machado-Joseph disease. The main nonmotor manifestations of Machado-Joseph disease described in previous data and discussed in this article are: sleep disorders, cognitive and affective disturbances, psychiatric symptoms, olfactory dysfunction, peripheral neuropathy, pain, cramps, fatigue, nutritional problems, and dysautonomia. In addition, we conducted a brief discussion of noncerebellar motor manifestations, highlighting movement disorders. © 2013 Movement Disorder Society. Copyright © 2013 Movement Disorder Society.

  17. Neutronic reactor

    DOEpatents

    Carleton, John T.

    1977-01-25

    A graphite-moderated nuclear reactor includes channels between blocks of graphite and also includes spacer blocks between adjacent channeled blocks with an axis of extension normal to that of the axis of elongation of the channeled blocks to minimize changes in the physical properties of the graphite as a result of prolonged neutron bombardment.

  18. Sonochemical Reactors.

    PubMed

    Gogate, Parag R; Patil, Pankaj N

    2016-10-01

    Sonochemical reactors are based on the generation of cavitational events using ultrasound and offer immense potential for the intensification of physical and chemical processing applications. The present work presents a critical analysis of the underlying mechanisms for intensification, available reactor configurations and overview of the different applications exploited successfully, though mostly at laboratory scales. Guidelines have also been presented for optimum selection of the important operating parameters (frequency and intensity of irradiation, temperature and liquid physicochemical properties) as well as the geometric parameters (type of reactor configuration and the number/position of the transducers) so as to maximize the process intensification benefits. The key areas for future work so as to transform the successful technique at laboratory/pilot scale into commercial technology have also been discussed. Overall, it has been established that there is immense potential for sonochemical reactors for process intensification leading to greener processing and economic benefits. Combined efforts from a wide range of disciplines such as material science, physics, chemistry and chemical engineers are required to harness the benefits at commercial scale operation.

  19. NEUTRONIC REACTORS

    DOEpatents

    Anderson, H.L.

    1958-10-01

    The design of control rods for nuclear reactors are described. In this design the control rod consists essentially of an elongated member constructed in part of a neutron absorbing material and having tube means extending therethrough for conducting a liquid to cool the rod when in use.

  20. NEUTRONIC REACTOR

    DOEpatents

    Creutz, E.C.; Ohlinger, L.A.; Weinberg, A.M.; Wigner, E.P.; Young, G.J.

    1959-10-27

    BS>A reactor cooled by water, biphenyl, helium, or other fluid with provision made for replacing the fuel rods with the highest plutonium and fission product content without disassembling the entire core and for promptly cooling the rods after their replacement in order to prevent build-up of heat from fission product activity is described.

  1. Neutronic reactor

    DOEpatents

    Wende, Charles W. J.

    1976-08-17

    A safety rod for a nuclear reactor has an inner end portion having a gamma absorption coefficient and neutron capture cross section approximately equal to those of the adjacent shield, a central portion containing materials of high neutron capture cross section and an outer end portion having a gamma absorption coefficient at least equal to that of the adjacent shield.

  2. Machado-Joseph Disease: from first descriptions to new perspectives

    PubMed Central

    2011-01-01

    Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represents the most common form of SCA worldwide. MJD is an autosomal dominant neurodegenerative disorder of late onset, involving predominantly the cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems; although sharing features with other SCAs, the identification of minor, but more specific signs, facilitates its differential diagnosis. MJD presents strong phenotypic heterogeneity, which has justified the classification of patients into three main clinical types. Main pathological lesions are observed in the spinocerebellar system, as well as in the cerebellar dentate nucleus. MJD's causative mutation consists in an expansion of an unstable CAG tract in exon 10 of the ATXN3 gene, located at 14q32.1. Haplotype-based studies have suggested that two main founder mutations may explain the present global distribution of the disease; the ancestral haplotype is of Asian origin, and has an estimated age of around 5,800 years, while the second mutational event has occurred about 1,400 years ago. The ATXN3 gene encodes for ataxin-3, which is ubiquitously expressed in neuronal and non-neuronal tissues, and, among other functions, is thought to participate in cellular protein quality control pathways. Mutated ATXN3 alleles consensually present about 61 to 87 CAG repeats, resulting in an expanded polyglutamine tract in ataxin-3. This altered protein gains a neurotoxic function, through yet unclear mechanisms. Clinical variability of MJD is only partially explained by the size of the CAG tract, which leaves a residual variance that should be explained by still unknown additional factors. Several genetic tests are available for MJD, and Genetic Counseling Programs have been created to better assist the affected families, namely on what concerns the possibility of pre-symptomatic testing. The main goal of this review was to bring together updated knowledge on MJD, covering

  3. Cytokines in Machado Joseph Disease/Spinocerebellar Ataxia 3.

    PubMed

    da Silva Carvalho, Gerson; Saute, Jonas Alex Morales; Haas, Clarissa Branco; Torrez, Vitor Rocco; Brochier, Andressa Wigner; Souza, Gabriele Nunes; Furtado, Gabriel Vasata; Gheno, Tailise; Russo, Aline; Monte, Thais Lampert; Schumacher-Schuh, Artur; D'Avila, Rui; Donis, Karina Carvalho; Castilhos, Raphael Machado; Souza, Diogo Onofre; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Camey, Suzi; Portela, Luis Valmor; Jardim, Laura Bannach

    2016-08-01

    The aim of the present study is to describe the serum concentrations of a broad spectrum of cytokines in symptomatic and asymptomatic carriers of Machado Joseph disease (SCA3/MJD) CAG expansions. Molecularly confirmed carriers and controls were studied. Age at onset, disease duration, and clinical scales Scale for the Assessment and Rating of Ataxia (SARA), Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), SCA Functional Index (SCAFI), and Composite Cerebellar Functional Score (CCFS) were obtained from the symptomatic carriers. Serum was obtained from all individuals and a cytokine panel "consisted of" eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, monokine induced by gamma interferon (MIG), macrophage inflammatory protein (MIP)-a, MIP-b, regulated on activation, normal T cell expressed and secreted (RANTES) and tumor necrosis factor (TNF)-α was analyzed. In a subgroup of symptomatic carriers, the cytokine panel was repeated after 360 days. Cytokine distribution among groups was studied by discriminant analysis; changes in serum levels after 360 days were studied by generalized estimation equation. Sixty-six symptomatic carriers, 13 asymptomatic carriers, and 43 controls were studied. No differences in cytokine patterns were found between controls and carriers of the CAG expansions or between controls and symptomatic carriers only. In contrast, eotaxin concentrations were significantly higher in asymptomatic than in symptomatic carriers or in controls (p = 0.001, ANCOVA). Eotaxin did not correlate with age, disease duration, CAG expansion, NESSCA score, and SARA score. Among symptomatic carriers, eotaxin dropped after 360 days (p = 0.039, GEE). SCA3/MJD patients presented a benign pattern of

  4. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  5. 77 FR 61657 - Indiana Northeastern Railroad Company-Abandonment Exemption-In Branch and St. Joseph Counties, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... St. Joseph Counties, MI Indiana Northeastern Railroad Company (IN) has filed a verified notice of.... Joseph County, Mich. (the Line). The Line traverses United States Postal Service Zip Codes 49036, 49028... .'' Decided: October 2, 2012. By the Board, Rachel D. Campbell, Director, Office of Proceedings. Derrick A...

  6. NUCLEAR REACTOR

    DOEpatents

    Grebe, J.J.

    1959-12-15

    A reactor which is particularly adapted tu serve as a heat source for a nuclear powered alrcraft or rocket is described. The core of this reactor consists of a porous refractory modera;or body which is impregnated with fissionable nuclei. The core is designed so that its surface forms tapered inlet and outlet ducts which are separated by the porous moderator body. In operation a gaseous working fluid is circulated through the inlet ducts to the surface of the moderator, enters and passes through the porous body, and is heated therein. The hot gas emerges into the outlet ducts and is available to provide thrust. The principle advantage is that tremendous quantities of gas can be quickly heated without suffering an excessive pressure drop.

  7. REACTOR UNLOADING

    DOEpatents

    Leverett, M.C.

    1958-02-18

    This patent is related to gas cooled reactors wherein the fuel elements are disposed in vertical channels extending through the reactor core, the cooling gas passing through the channels from the bottom to the top of the core. The invention is a means for unloading the fuel elements from the core and comprises dump values in the form of flat cars mounted on wheels at the bottom of the core structure which support vertical stacks of fuel elements. When the flat cars are moved, either manually or automatically, for normal unloading purposes, or due to a rapid rise in the reproduction ratio within the core, the fuel elements are permtted to fall by gravity out of the core structure thereby reducing the reproduction ratio or stopping the reaction as desired.

  8. NEUTRONIC REACTOR

    DOEpatents

    Wade, E.J.

    1958-09-16

    This patent relates to a reflector means for a neutronic reactor. A reflector comprised of a plurality of vertically movable beryllium control members is provided surrounding the sides of the reactor core. An absorber of fast neutrons comprised of natural uramum surrounds the reflector. An absorber of slow neutrons surrounds the absorber of fast neutrons and is formed of a plurality of beryllium blocks having natural uranium members distributcd therethrough. in addition, a movable body is positioned directly below the core and is comprised of a beryllium reflector and an absorbing member attached to the botiom thereof, the absorbing member containing a substance selected from the goup consisting of natural urantum and Th/sup 232/.

  9. REACTOR MONITORING

    DOEpatents

    Bugbee, S.J.; Hanson, V.F.; Babcock, D.F.

    1959-02-01

    A neutron density inonitoring means for reactors is described. According to this invention a tunnel is provided beneath and spaced from the active portion of the reactor and extends beyond the opposite faces of the activc portion. Neutron beam holes are provided between the active portion and the tunnel and open into the tunnel near the middle thereof. A carriage operates back and forth in the tunnel and is adapted to convey a neutron detector, such as an ion chamber, and position it beneath one of the neutron beam holes. This arrangement affords convenient access of neutron density measuring instruments to a location wherein direct measurement of neutron density within the piles can be made and at the same time affords ample protection to operating personnel.

  10. Nuclear reactor

    DOEpatents

    Wade, Elman E.

    1979-01-01

    A nuclear reactor including two rotatable plugs and a positive top core holddown structure. The top core holddown structure is divided into two parts: a small core cover, and a large core cover. The small core cover, and the upper internals associated therewith, are attached to the small rotating plug, and the large core cover, with its associated upper internals, is attached to the large rotating plug. By so splitting the core holddown structures, under-the-plug refueling is accomplished without the necessity of enlarging the reactor pressure vessel to provide a storage space for the core holddown structure during refueling. Additionally, the small and large rotating plugs, and their associated core covers, are arranged such that the separation of the two core covers to permit rotation is accomplished without the installation of complex lifting mechanisms.

  11. NUCLEAR REACTOR

    DOEpatents

    Treshow, M.

    1958-08-19

    A neuclear reactor is described of the heterogeneous type and employing replaceable tubular fuel elements and heavy water as a coolant and moderator. A pluraltty of fuel tubesa having their axes parallel, extend through a tank type pressure vessel which contatns the liquid moderator. The fuel elements are disposed within the fuel tubes in the reaetive portion of the pressure vessel during normal operation and the fuel tubes have removable plug members at each end to permit charging and discharging of the fuel elements. The fuel elements are cylindrical strands of jacketed fissionable material having helical exterior ribs. A bundle of fuel elements are held within each fuel tube with their longitudinal axes parallel, the ribs serving to space them apart along their lengths. Coolant liquid is circulated through the fuel tubes between the spaced fuel elements. Suitable control rod and monitoring means are provided for controlling the reactor.

  12. Evaluation of in-vessel corium retention through external reactor vessel cooling for integral reactor

    SciTech Connect

    Park, R. J.; Lee, J. R.; Kim, S. B.; Jin, Y.; Kim, H. Y.

    2012-07-01

    In-vessel corium retention through external reactor vessel cooling (IVR-ERVC) for a small integral reactor has been evaluated to determine the thermal margin for the prevention of a reactor vessel failure. A thermal load analysis from the corium pool to the outer reactor vessel wall in the lower plenum of the reactor vessel has been performed to determine the heat flux distribution. The critical heat flux (CHF) on the outer reactor vessel wall has been determined to fix the maximum heat removal rate through the external coolant between the outer reactor vessel and the insulation of the reactor vessel. Finally, the thermal margin has been evaluated by comparison of the thermal load with the maximum heat removal rate of the CHF on the outer reactor vessel wall. The maximum heat flux from the corium pool to the outer reactor vessel is estimated at approximately 0.25 MW/m{sup 2} in the metallic layer because of the focusing effect. The CHF of the outer reactor vessel is approximately 1.1 MW/m{sup 2} because of a two phase natural circulation mass flow. Since the thermal margin for the IVR-ERVC is sufficient, the reactor vessel integrity is maintained during a severe accident of a small integral reactor. (authors)

  13. Neutronic reactor

    DOEpatents

    Lewis, Warren R.

    1978-05-30

    A graphite-moderated, water-cooled nuclear reactor including a plurality of rectangular graphite blocks stacked in abutting relationship in layers, alternate layers having axes which are normal to one another, alternate rows of blocks in alternate layers being provided with a channel extending through the blocks, said channeled blocks being provided with concave sides and having smaller vertical dimensions than adjacent blocks in the same layer, there being nuclear fuel in the channels.

  14. NUCLEAR REACTORS

    DOEpatents

    Long, E.; Ashby, J.W.

    1958-09-16

    ABS>A graphite moderator structure is presented for a nuclear reactor compriscd of an assembly of similarly orientated prismatic graphite blocks arranged on spaced longitudinal axes lying in common planes wherein the planes of the walls of the blocks are positioned so as to be twisted reintive to the planes of said axes so thatthe unlmpeded dtrect paths in direction wholly across the walls of the blocks are limited to the width of the blocks plus spacing between the blocks.

  15. NUCLEAR REACTOR

    DOEpatents

    Grebe, J.J.

    1961-01-24

    A core structure for neutronic reactors adapted for the propulsion of aircraft and rockets is offered. The core is designed for cooling by gaseous media, and comprises a plurality of hollow tapered tubular segments of a porous moderating material impregniated with fissionable fuel nested about a common axis. Alternate ends of the segments are joined. In operation a coolant gas passes through the porous structure and is heated.

  16. NUCLEAR REACTORS

    DOEpatents

    Koch, L.J.; Rice, R.E. Jr.; Denst, A.A.; Rogers, A.J.; Novick, M.

    1961-12-01

    An active portion assembly for a fast neutron reactor is described wherein physical distortions resulting in adverse changes in the volume-to-mass ratio are minimized. A radially expandable locking device is disposed within a cylindrical tube within each fuel subassembly within the active portion assembly, and clamping devices expandable toward the center of the active portion assembly are disposed around the periphery thereof. (AEC)

  17. Oscillating liquid flow ICF Reactor

    SciTech Connect

    Petzoldt, R.W.

    1990-12-14

    Oscillating liquid flow in a falling molten salt inertial confinement fusion reactor is predicted to rapidly clear driver beam paths of residual liquid droplets. Oscillating flow will also provide adequate neutron and x-ray protection for the reactor structure with a short (2-m) fall distance permitting an 8 Hz repetition rate. A reactor chamber configuration is presented with specific features to clear the entire heavy-ion beam path of splashed molten salt. The structural components, including the structure between beam ports, are shielded. 3 refs., 12 figs.

  18. REACTOR CONTROL

    DOEpatents

    Ruano, W.J.

    1957-12-10

    This patent relates to nuclear reactors of the type which utilize elongited rod type fuel elements immersed in a liquid moderator and shows a design whereby control of the chain reaction is obtained by varying the amount of moderator or reflector material. A central tank for containing liquid moderator and fuel elements immersed therein is disposed within a surrounding outer tank providing an annular space between the two tanks. This annular space is filled with liquid moderator which functions as a reflector to reflect neutrons back into the central reactor tank to increase the reproduction ratio. Means are provided for circulating and cooling the moderator material in both tanks and additional means are provided for controlling separately the volume of moderator in each tank, which latter means may be operated automatically by a neutron density monitoring device. The patent also shows an arrangement for controlling the chain reaction by injecting and varying an amount of poisoning material in the moderator used in the reflector portion of the reactor.

  19. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    PubMed

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  20. Calculation of the temperature in the container unit with a modified design for the production of 99Mo at the VVR-Ts research reactor facility (IVV.10M)

    NASA Astrophysics Data System (ADS)

    Kazantsev, A. A.; Sergeev, V. V.; Kochnov, O. Yu.

    2015-12-01

    The temperature regime is calculated for two different designs of containers with uranium-bearing material for the upgraded VVR-Ts research reactor facility (IVV.10M). The containers are to be used in the production of 99Mo. It is demonstrated that the modification of the container design leads to a considerable temperature reduction and an increase in the near-wall boiling margin and allows one to raise the amount of material loaded into the container. The calculations were conducted using the international thermohydraulic contour code TRAC intended to analyze the technical safety of water-cooled nuclear power units.

  1. Whole genome sequence of Clostridium bornimense strain M2/40 isolated from a lab-scale mesophilic two-phase biogas reactor digesting maize silage and wheat straw.

    PubMed

    Hahnke, Sarah; Wibberg, Daniel; Tomazetto, Geizecler; Pühler, Alfred; Klocke, Michael; Schlüter, Andreas

    2014-08-20

    The bacterium Clostridium bornimense M2/40 is a mesophilic, anaerobic bacterium isolated from a two-phase biogas reactor continuously fed with maize silage and 5% wheat straw. Grown on glucose, it produced H2, CO2, formiate, lactate and propionate as the main fermentation products, of which some compounds serve as substrates for methanogenic Archaea to form methane. Here, the whole genome sequence of the bacterium consisting of two circular replicons is reported. This genome information provides the basis for further studies addressing metabolic features of the isolate and its role in anaerobic biomass degradation.

  2. Calculation of the temperature in the container unit with a modified design for the production of {sup 99}Mo at the VVR-Ts research reactor facility (IVV.10M)

    SciTech Connect

    Kazantsev, A. A.; Sergeev, V. V.; Kochnov, O. Yu.

    2015-12-15

    The temperature regime is calculated for two different designs of containers with uranium-bearing material for the upgraded VVR-Ts research reactor facility (IVV.10M). The containers are to be used in the production of {sup 99}Mo. It is demonstrated that the modification of the container design leads to a considerable temperature reduction and an increase in the near-wall boiling margin and allows one to raise the amount of material loaded into the container. The calculations were conducted using the international thermohydraulic contour code TRAC intended to analyze the technical safety of water-cooled nuclear power units.

  3. A Study of the Engraving of the M855 5.56-mm Projectile

    DTIC Science & Technology

    2009-03-01

    A Study of the Engraving of the M855 5.56-mm Projectile by Joseph South, Aristedes Yiournas, Jordan Wagner, John Brown, and Robert Kaste...ARL-TR-4743 March 2009 A Study of the Engraving of the M855 5.56-mm Projectile Joseph South, Aristedes Yiournas, Jordan Wagner, John Brown...approach to evaluate the effect of engraving on the M855 projectile as a function of propellant charge. The result of this combined approach is the

  4. Hydrologic and water-quality characteristics of a Wetland receiving wastewater effluent in St. Joseph, Minnesota

    USGS Publications Warehouse

    Brown, Rob G.; Stark, James R.

    1989-01-01

    Hydrologic and water-quality characteristics were determined for a wetland being used for tertiary treatment of wastewater in St. Joseph, Minnesota. The wetland consists of spruce-tamarack fen and a cattail marsh, with the wastewater being discharged into the fen, and the fen draining into the marsh. The wetland is underlain by flat-lying glacial outwash that ranges from 0 to greater than 20 m in thickness. Horizontal ground-water movement in the outwash aquifer is toward the wetland from the south, east, and west. There is a strong upward vertical hydraulic gradient (about 0.1) in the ground-water flow system beneath and around the wetland. Regionally, the glacial-outwash aquifer is unconfined, but it is confined or partly confined locally by peat deposits under the wetland. Analysis of the hydrologic balance of the fen from October 1985 through September 1986 indicates that the inflow was 44 percent ground water, 38 percent wastewater, 11 percent runoff (storm sewer), and 7 percent precipitation. The fen outflow was 93 percent surface water and 7 percent evapotranspiration. Inflow to the marsh was 74 percent surface water, 21 percent ground water, and 5 percent precipitation. Outflow from the marsh was 94 percent surface water and 6 percent evapotranspiration. Wastewater contributed 74,996, and 81 percent of the total suspended solids, total phosphorus, and total ammonia plus organic nitrogen in the fen, respectively. Other chemical inputs were from the storm sewer, ground water, and atmospheric deposition. The fen was found to retain 34, 14, and 14 percent of the suspended solids, total phosphorus, and total ammonia plus organic nitrogen, respectively. The marsh retained 44, 18, and 22 percent of these three constituents, respectively.

  5. Further refinement of the locus for Machado-Joseph disease (MJD) gene

    SciTech Connect

    Endo, K.; Tanaka, H.; Takiyama, Y.

    1994-09-01

    Machado-Joseph disease (MJD) is an autosomal dominant, multi-system, neurodegenerative disorder involving predominantly cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems. We have discovered that the gene for MJD is mapped to chromosome 14q24.3-32.1 in a region of 29 cM between D14S53 and D14S45 using 7 microsatellite DNA markers. To further characterize the candidate region for MJD gene, we analyzed 80 individuals including 35 affected members from 5 Japanese MJD families (3 families are pathologically proven and 2 families are diagnosed based on the clinical manifestations), using 10 new microsatellite DNA markers (D14S76, D14S61, D14S59, D14S67, D14S291, D14S280, D14S81, D14S265, D14S62, and D14S65) in the region defined by previous linkage analysis. High lod scores of 9.227, 3.5207, 9.0320, and 6.7032 were obtained at D14S48, D14S291, D14S280, and D14S81 at recombination fractions of 0.00, 0.05, 0.01, and 0.05, respectively. We have observed recombination events at D14S291 and D14S81 in affected individuals while no recombination events were observed at D14S280. The results indicate that the gene for MJD is likely to be located in the region of 4CM between D14S291 and D14S81. The identification of multiple informative flanking markers should facilitate positional cloning of the gene for MJD.

  6. Cognitive deficits in Machado-Joseph disease correlate with hypoperfusion of visual system areas.

    PubMed

    Braga-Neto, Pedro; Dutra, Lívia Almeida; Pedroso, José Luiz; Felício, André C; Alessi, Helena; Santos-Galduroz, Ruth F; Bertolucci, Paulo Henrique F; Castiglioni, Mário Luiz V; Bressan, Rodrigo Affonseca; de Garrido, Griselda Esther Jara; Barsottini, Orlando Graziani Povoas; Jackowski, Andrea

    2012-12-01

    Cognitive and olfactory impairments have previously been demonstrated in patients with spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD)-SCA3/MJD. We investigated changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) imaging in a cohort of Brazilian patients with SCA3/MJD. The aim of the present study was to evaluate the correlation among rCBF, cognitive deficits, and olfactory dysfunction in SCA3/MJD. Twenty-nine genetically confirmed SCA3/MJD patients and 25 control subjects were enrolled in the study. The severity of cerebellar symptoms was measured using the International Cooperative Ataxia Rating Scale and the Scale for the Assessment and Rating of Ataxia. Psychiatric symptoms were evaluated by the Hamilton Anxiety Scale and Beck Depression Inventory. The neuropsychological assessment consisted of Spatial Span, Symbol Search, Picture Completion, the Stroop Color Word Test, Trail Making Test (TMT), and Phonemic Verbal Fluency. Subjects were also submitted to odor identification evaluation using the 16-item Sniffin' Sticks. SPECT was performed using ethyl cysteine dimer labeled with technetium-99m. SCA3/MJD patients showed reduced brain perfusion in the cerebellum, temporal, limbic, and occipital lobes compared to control subjects (pFDR <0.001). A significant positive correlation was found between the Picture Completion test and perfusion of the left parahippocampal gyrus and basal ganglia in the patient group as well as a negative correlation between the TMT part A and bilateral thalamus perfusion. The visuospatial system is affected in patients with SCA3/MJD and may be responsible for the cognitive deficits seen in this disease.

  7. Highlighting High Performance Buildings: Adam Joseph Lewis Center for Environmental Studies

    SciTech Connect

    2002-11-01

    Oberlin College's Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.

  8. General Education Assessment and Fulfilling the Mercy Mission at the University of Saint Joseph

    ERIC Educational Resources Information Center

    Callahan, Kevin J.

    2014-01-01

    This article describes the processes and procedures the University of Saint Joseph used to conduct a systematic assessment of mission-related student-learning outcomes found in the General Education curriculum, and thus assess how well the institution was fulfilling its Mercy mission. The assessment showed student learning strengths and gaps and…

  9. Archaeological Investigations at Site 45-DO-326, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1984-01-01

    idetmlifil by blak niaber) Cultural Resources, Washington Microblades Columbia River rrehistory Cascade Phase Chief Joseph Dam Project Archaeology Frenchman ...Stone tool manufacture, primarily as part of a generalized flake tool Industry utilizing imported cryptocrystalline stones, was relatively consistent...unifacial or bifacial edge on a cryptocrystalline tool likely evidences light cutting or scraping use on a soft, elastic material. However, smoothing

  10. The Joseph Bellamy House: Great Awakening in Puritan New England. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Pape, Barbara Bradbury

    The small rural town of Bethlehem, Connecticut, contains pristine examples of modest 18th-century houses that surround a charming village green. Opposite the village green, the Reverend Joseph Bellamy's immense white clapboard house rises from a hilltop, an imposing presence that makes the village appear diminutive. The house stands today as a…

  11. Joseph Walker, a Black Playwright, Exhorts Counselors and Black People to Deal With Themselves

    ERIC Educational Resources Information Center

    Walker, Joseph

    1976-01-01

    This is an interview with Joseph Walker, black playwright. He attempts to reflect back to the black community their experience in a white controlled world. In this interview, he discusses his views of the black experience, the pressures on man-woman relationships, and the role of black psychiatry. (NG)

  12. Cervical and ocular vestibular evoked potentials in Machado-Joseph disease: Functional involvement of otolith pathways.

    PubMed

    Ribeiro, Rodrigo Souza; Pereira, Melissa Marques; Pedroso, José Luiz; Braga-Neto, Pedro; Barsottini, Orlando Graziani Povoas; Manzano, Gilberto Mastrocola

    2015-11-15

    Machado-Joseph disease is defined as an autosomal dominant ataxic disorder caused by degeneration of the cerebellum and its connections and is associated with a broad range of clinical symptoms. The involvement of the vestibular system is responsible for several symptoms and signs observed in the individuals affected by the disease. We measured cervical and ocular vestibular evoked myogenic potentials in a sample of Machado-Joseph disease patients in order to assess functional pathways involved. Bilateral measures of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP) were obtained from 14 symptomatic patients with genetically proven Machado-Joseph disease and compared with those from a control group of 20 healthy subjects. Thirteen (93%) patients showed at least one abnormal test result; oVEMP and cVEMP responses were absent in 17/28 (61%) and 11/28 (39%) measures, respectively; and prolonged latency of cVEMP was found in 3/28 (11%) measures. Of the 13 patients with abnormal responses, 9/13 (69%) patients showed discordant abnormal responses: four with absent oVEMP and present cVEMP, two with absent cVEMP and present oVEMP, and three showed unilateral prolonged cVEMP latencies. Both otolith-related vestibulocollic and vestibulo-ocular pathways are severely affected in Machado-Joseph disease patients evaluated by VEMPs. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. The Plight of the American Writer and Joseph Brodsky in Exile.

    ERIC Educational Resources Information Center

    Updike, John; Jacoby, Susan

    1994-01-01

    Two articles originally published in the 1970s are reprinted. The first argues that the American writer no longer knows what is expected of him and has difficulty engaging in conversation with the reader. The second examines the work and teaching of Joseph Brodsky, a Russian poet, while in the United States. (MSE)

  14. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    ERIC Educational Resources Information Center

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  15. Assessing conservation effects on water quality in the St. Joseph River Watershed

    USDA-ARS?s Scientific Manuscript database

    Agriculture is a major contributor to non-point source pollution of streams, rivers and lakes. The St. Joseph River is a major drinking water source in northeastern Indiana that has been contaminated by chemicals in runoff. A Source Water Protection Initiative project began in 2002, with the focus ...

  16. Astronaut Joseph P. Allen on flight deck taking photographs of the earth

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Astronaut Joseph P. Allen, STS-5 mission specialist, lets a spot-meter float free during a period devoted to out the window photographs of the Earth from the orbiting Columbia. Allen is on the flight deck positioned behind the pilot's station.

  17. Conceiving of Concept Maps to Foster Meaningful Learning: An Interview with Joseph D. Novak

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2004-01-01

    Joseph Novak discusses the concept of mapping to capture and archive expert knowledge. He worked in various corporations where he used the concept of mapping for research and development efforts and to create and transfer knowledge and information in corporate environments.

  18. Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2006-01-01

    This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

  19. Exceptional Scholarship and Democratic Agendas: Interviews with John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni

    ERIC Educational Resources Information Center

    Mullen, Carol A.

    2009-01-01

    This portraiture study of four exceptional scholars in education--John Goodlad, John Hoyle, Joseph Murphy, and Thomas Sergiovanni--provides insight into their scholarly work and life habits, direction and aspirations, assessment and analysis of major trends in the profession, and advice for aspiring leaders and academics. Telephone interviews with…

  20. Joseph Schwab, Self-Study of Teaching and Teacher Education Practices Proponent? A Personal Perspective

    ERIC Educational Resources Information Center

    Craig, Cheryl J.

    2008-01-01

    The field of self-study of teaching and teacher education practices, like a number of other areas of inquiry, appears negligent in paying intellectual debt to Joseph Schwab who revolutionalized the fields of curriculum and teaching in the 1970s with his ideas about the practical. In this article, I trace my personal journey of coming to know…

  1. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    ERIC Educational Resources Information Center

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of…

  2. Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution

    ERIC Educational Resources Information Center

    Clay, Richard

    2008-01-01

    This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…

  3. Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution

    ERIC Educational Resources Information Center

    Clay, Richard

    2008-01-01

    This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…

  4. From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2010-01-01

    This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…

  5. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    ERIC Educational Resources Information Center

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  6. Recent theoretical chemical dynamics at Rochester in the paths of Joseph O. Hirschfelder

    NASA Technical Reports Server (NTRS)

    George, T. F.; Lam, K.-S.; Bhattacharyya, D. K.; Hutchinson, M.; Zimmerman, I. H.; Devries, P. L.; Yuan, J.-M.

    1982-01-01

    A review of recent theoretical studies of gas-phase molecular rate processes, including various effects of laser radiation, is presented in the context of the extensive and influential work of Joseph O. Hirschfelder during the past half-century. The topics addressed are energy transfer, chemical reactions, unimolecular dissociation, transition states, and bound-continuum interactions.

  7. What's in a Coauthor?: (Re)Locating Joseph Denney in Composition History

    ERIC Educational Resources Information Center

    Davis, Ivan

    2012-01-01

    This article reassesses the Fred Newton Scott and Joseph Villiers Denney collaborative textbook authorship by emphasizing Denney's generally overlooked contributions to that coauthorship and to the field of composition generally. Through an examination of Denney's scholarly work and his personal correspondence with Scott during the period marking…

  8. Reflections on Preparing Educators to Evaluate the Efficacy of Educational Technology: An Interview with Joseph South

    ERIC Educational Resources Information Center

    Bull, Glen; Spector, J. Michael; Persichitte, Kay; Meiers, Ellen

    2017-01-01

    Joseph South, an educational researcher, technology consultant, and former director of the U.S. Office of Educational Technology participated in a research initiative on Educational Technology Efficacy Research organized by the Jefferson Education Accelerator, Digital Promise, and the Curry School of Education at the University of Virginia. The…

  9. What's in a Coauthor?: (Re)Locating Joseph Denney in Composition History

    ERIC Educational Resources Information Center

    Davis, Ivan

    2012-01-01

    This article reassesses the Fred Newton Scott and Joseph Villiers Denney collaborative textbook authorship by emphasizing Denney's generally overlooked contributions to that coauthorship and to the field of composition generally. Through an examination of Denney's scholarly work and his personal correspondence with Scott during the period marking…

  10. A Curriculum for Character Education: Joseph Schwab and the Ramah Camps

    ERIC Educational Resources Information Center

    Cohen, Burton; Pereira, Peter; Roby, Thomas; Block, Alan

    2005-01-01

    Joseph Schwab (1909-1988) is known for his scathing critique of curriculum theory and its over reliance on quantitative models derived from social science theories. From the late 1950's through the middle 1960's, Schwab was instrumental to efforts to create a new and more educationally sound curriculum for weekday religious schools in synagogues…

  11. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  12. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    ERIC Educational Resources Information Center

    Cooke, Bill

    2010-01-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious…

  13. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    ERIC Educational Resources Information Center

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  14. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    ERIC Educational Resources Information Center

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of…

  15. Joseph Priestley Is the Focus as Modern Chemistry Celebrates Its Second Century

    ERIC Educational Resources Information Center

    Bernheim, Robert A.; Olofson, Roy A.

    1974-01-01

    This article describes a meeting in 1874, seen to be the origin of the American Chemical Society, which commemorated the 100th anniversary of Joseph Priestley's discovery of oxygen. The remainder of the article is concerned with Priestley's scientific contributions and their implications. (DT)

  16. The Oral History of Evaluation: The Professional Development of Joseph Wholey

    ERIC Educational Resources Information Center

    Miller, Robin Lin; Caracelli, Valerie

    2013-01-01

    Joseph S. Wholey is Professor Emeritus in the University of Southern California's (USC) School of Public Policy, Planning, and Development. He received his BA from Catholic University, Phi Beta Kappa and his MA in mathematics and PhD in philosophy from Harvard University. His work focuses on the use of strategic planning, performance measurement,…

  17. Astronauts Joseph Allen rides cherry picker over stowage area/work station

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Joseph P. Allen rides a cherry picker over to a stowage area/work station to wrap up extravehicular activity (EVA) duties above Earth. The cherry picker is a union of the mobile foot restraint and the remote manipulator system (RMS), controlled from inside Discovery's cabin. The Westar VI/PAM-D satellite is pictured secured in Discovery's cargo bay.

  18. An Assessment of the Importance of Joseph Mayer Rice in American Educational Research.

    ERIC Educational Resources Information Center

    Banerji, Madhabi

    Historical accounts of the American public school system vary on whether Joseph Mayer Rice, the 19th century physician-turned-journalist who wrote numerous studies aimed at educational reform, is important in the history of educational research and on the nature of his influence in the field. An examination of the treatment of Rice by educational…

  19. From Chemical Analysis to Analyzing Chemical Education: An Interview with Joseph J. Lagowski

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2010-01-01

    This interview provides glimpses of Joseph J. Lagowski and his life from the time he played with a Gilbert chemistry set, to his tenure at The University of Texas at Austin. His initial interest in chemistry was further nurtured and developed thanks to an excellent high school teacher. In the interview, Lagowski discusses his research in…

  20. Painting as Rhetorical Performance: Joseph Wright's "An Experiment on a Bird in the Air Pump."

    ERIC Educational Resources Information Center

    Helmers, Marguerite

    2001-01-01

    Explores three broad areas of inquiry: what significance visual images have for rhetorical analysis; how a study of nonverbal material might be conducted; and whether visual explanations depend on the image or the viewer. Argues that viewers understand Joseph Wright's painting "The Air Pump" in terms of its subject, its exhibition space, the…

  1. Nuclear Reactors. Revised.

    ERIC Educational Resources Information Center

    Hogerton, John F.

    This publication is one of a series of information booklets for the general public published by the United States Atomic Energy Commission. Among the topics discussed are: How Reactors Work; Reactor Design; Research, Teaching, and Materials Testing; Reactors (Research, Teaching and Materials); Production Reactors; Reactors for Electric Power…

  2. Nuclear reactor

    DOEpatents

    Pennell, William E.; Rowan, William J.

    1977-01-01

    A nuclear reactor in which the core components, including fuel-rod assemblies, control-rod assemblies, fertile rod-assemblies, and removable shielding assemblies, are supported by a plurality of separate inlet modular units. These units are referred to as inlet module units to distinguish them from the modules of the upper internals of the reactor. The modular units are supported, each removable independently of the others, in liners in the supporting structure for the lower internals of the reactor. The core assemblies are removably supported in integral receptacles or sockets of the modular units. The liners, units, sockets and assmblies have inlet openings for entry of the fluid. The modular units are each removably mounted in the liners with fluid seals interposed between the opening in the liner and inlet module into which the fluid enters and the upper and lower portion of the liner. Each assembly is similarly mounted in a corresponding receptacle with fluid seals interposed between the openings where the fluid enters and the lower portion of the receptacle or fitting closely in these regions. As fluid flows along each core assembly a pressure drop is produced along the fluid so that the fluid which emerges from each core assembly is at a lower pressure than the fluid which enters the core assembly. However because of the seals interposed in the mountings of the units and assemblies the pressures above and below the units and assemblies are balanced and the units are held in the liners and the assemblies are held in the receptacles by their weights as they have a higher specific gravity than the fluid. The low-pressure spaces between each module and its liner and between each core assembly and its module is vented to the low-pressure regions of the vessel to assure that fluid which leaks through the seals does not accumulate and destroy the hydraulic balance.

  3. Distribution and relative abundance of fishes in littoral areas of Chief Joseph Reservoir, Columbia River

    USGS Publications Warehouse

    Gadomski, Dena M.; Venditti, David A.; Robinson, T. Craig; Beeman, John W.; Maule, Alec G.

    2004-01-01

    We surveyed fish assemblages in littoral areas of Chief Joseph Reservoir of the upper Columbia River to aid in understanding this ecosystem. Fish distributions and abundances were examined during April-July 1999 in relation to environmental conditions in the reservoir. We also compared the fish assemblages in Chief Joseph reservoir in 1999 to a past study conducted during 1974-1975, and to assemblages in other areas of the Columbia River. During 67 hr of electrofishing and 78 beach seine hauls in Chief Joseph Reservoir, 7460 fishes representing 8 families were collected. The majority of the catch was native – northern pikeminnow; redside shiners; longnose, bridgelip, and largescale suckers; and sculpins. The most abundant introduced species was walleye, and one species, rainbow trout, was mostly of net-pen origin. Larger sizes of suckers and northern pikeminnow were most abundant in the upper reservoir, likely due to upstream spawning migrations. The lower reservoir contained greater abundances of smaller fishes, and this area had lower flows, smaller substrates, and more complex shorelines that offered these fishes refugia. Only adult suckers displayed significant differences in abundances related to substrate. The relative abundances of species appeared to have changed since the 1970s, when the dominant fishes were northern pikeminnow, peamouth, largescale suckers, and walleye. Fish assemblage differences between Chief Joseph Reservoir and lower Columbia River reservoirs were also evident due to the morphology of the reservoir, its more northerly location, and the lack of fish passage facilities at Chief Joseph Dam. Our study is one of the few descriptions of fishes in the upper Columbia Rivers.

  4. NUCLEAR REACTORS

    DOEpatents

    Long, E.; Ashley, J.W.

    1958-12-16

    A graphite moderator structure is described for a gas-cooled nuclear reactor having a vertical orlentation wherein the structure is physically stable with regard to dlmensional changes due to Wigner growth properties of the graphite, and leakage of coolant gas along spaces in the structure is reduced. The structure is comprised of stacks of unlform right prismatic graphite blocks positioned in layers extending in the direction of the lengths of the blocks, the adjacent end faces of the blocks being separated by pairs of tiles. The blocks and tiles have central bores which are in alignment when assembled and are provided with cooperatlng keys and keyways for physical stability.

  5. ELECTRONUCLEAR REACTOR

    DOEpatents

    Lawrence, E.O.; McMillan, E.M.; Alvarez, L.W.

    1960-04-19

    An electronuclear reactor is described in which a very high-energy particle accelerator is employed with appropriate target structure to produce an artificially produced material in commercial quantities by nuclear transformations. The principal novelty resides in the combination of an accelerator with a target for converting the accelerator beam to copious quantities of low-energy neutrons for absorption in a lattice of fertile material and moderator. The fertile material of the lattice is converted by neutron absorption reactions to an artificially produced material, e.g., plutonium, where depleted uranium is utilized as the fertile material.

  6. REACTOR COMPONETN

    DOEpatents

    Creutz, E.C.

    1959-10-27

    A reactor fuel element comprised of a slug of fissionable material disposed in a sheath of corrosion resistantmaterial is described. The sheath is in the form of a tubular container closed at one end and is in tight-fitting engagement with the peripheral sunface of the slug. An inner cap is insented into the open end of the sheath against the slug, which end is then bent around the inner cap and welded thereto. An outer cap is then welded around its peripheny to the bent portion of the container.

  7. Photocatalytic reactor

    DOEpatents

    Bischoff, B.L.; Fain, D.E.; Stockdale, J.A.D.

    1999-01-19

    A photocatalytic reactor is described for processing selected reactants from a fluid medium comprising at least one permeable photocatalytic membrane having a photocatalytic material. The material forms an area of chemically active sites when illuminated by light at selected wavelengths. When the fluid medium is passed through the illuminated membrane, the reactants are processed at these sites separating the processed fluid from the unprocessed fluid. A light source is provided and a light transmitting means, including an optical fiber, for transmitting light from the light source to the membrane. 4 figs.

  8. Search for sterile neutrinos at reactors

    NASA Astrophysics Data System (ADS)

    Yasuda, Osamu

    2011-09-01

    The sensitivity to the sterile neutrino mixing at very short baseline reactor neutrino experiments is investigated. In the case of conventional (thermal neutron) reactors it is found that the sensitivity is lost for ∆ m 2 ≳ 1 eV2 due to smearing of the reactor core size. On the other hand, in the case of an experimental fast neutron reactor Joyo, because of its small size, sensitivity to sin2 2 θ 14 can be as good as 0.03 for ∆ m 2 ˜ several eV2 with the Bugey-like detector setup.

  9. 76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... whether his licenses should be suspended or revoked, DEA lacks authority to revoke his registration... requires, as a condition of obtaining a registration, that a practitioner be ``authorized to dispense... 21 U.S.C. 824(a)(3), Congress expressly authorized the revocation of a DEA registration issued to...

  10. Three Experts on Quality Management: Philip B. Crosby, W. Edwards Deming, Joseph M. Juran

    DTIC Science & Technology

    1992-07-01

    Vilfredo Pareto . Pareto Juran targets training toward quality management prac- conducted studies of wealth distribution. He found that tices and...15 11. The Pareto diagram ........................................................................................... 16 12...taught the Japanre, among other things, Demning continues as a consultant and also conducts about the Pareto principle, which he popularized as the

  11. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.

    PubMed

    Mendonça, Liliana S; Nóbrega, Clévio; Hirai, Hirokazu; Kaspar, Brian K; Pereira de Almeida, Luís

    2015-02-01

    Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments such as gait ataxia, associated with multiple neuropathological changes including mutant ATXN3 inclusions, marked neuronal loss and atrophy of the cerebellum. Thus, an effective treatment of symptomatic patients with Machado-Joseph disease may require cell replacement, which we investigated in this study. For this purpose, we injected cerebellar neural stem cells into the cerebellum of adult Machado-Joseph disease transgenic mice and assessed the effect on the neuropathology, neuroinflammation mediators and neurotrophic factor levels and motor coordination. We found that upon transplantation into the cerebellum of adult Machado-Joseph disease mice, cerebellar neural stem cells differentiate into neurons, astrocytes and oligodendrocytes. Importantly, cerebellar neural stem cell transplantation mediated a significant and robust alleviation of the motor behaviour impairments, which correlated with preservation from Machado-Joseph disease-associated neuropathology, namely reduction of Purkinje cell loss, reduction of cellular layer shrinkage and mutant ATXN3 aggregates. Additionally, a significant reduction of neuroinflammation and an increase of neurotrophic factors levels was observed, indicating that transplantation of cerebellar neural stem cells also triggers important neuroprotective effects. Thus, cerebellar neural stem cells have the potential to be used as a cell replacement and neuroprotective approach for Machado-Joseph disease therapy.

  12. Hybrid adsorptive membrane reactor

    NASA Technical Reports Server (NTRS)

    Tsotsis, Theodore T. (Inventor); Sahimi, Muhammad (Inventor); Fayyaz-Najafi, Babak (Inventor); Harale, Aadesh (Inventor); Park, Byoung-Gi (Inventor); Liu, Paul K. T. (Inventor)

    2011-01-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  13. Hybrid adsorptive membrane reactor

    DOEpatents

    Tsotsis, Theodore T [Huntington Beach, CA; Sahimi, Muhammad [Altadena, CA; Fayyaz-Najafi, Babak [Richmond, CA; Harale, Aadesh [Los Angeles, CA; Park, Byoung-Gi [Yeosu, KR; Liu, Paul K. T. [Lafayette Hill, PA

    2011-03-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  14. Assessment of torsatrons as reactors

    SciTech Connect

    Lyon, J.F. ); Painter, S.L. )

    1992-12-01

    Stellarators have significant operational advantages over tokamaks as ignited steady-state reactors because stellarators have no dangerous disruptions and no need for continuous current drive or power recirculated to the plasma, both easing the first wall, blanket, and shield design; less severe constraints on the plasma parameters and profiles; and better access for maintenance. This study shows that a reactor based on the torsatron configuration (a stellarator variant) could also have up to double the mass utilization efficiency (MUE) and a significantly lower cost of electricity (COE) than a conventional tokamak reactor (ARIES-I) for a range of assumptions. Torsatron reactors can have much smaller coil systems than tokamak reactors because the coils are closer to the plasma and they have a smaller cross section (higher average current density because of the lower magnetic field). The reactor optimization approach and the costing and component models are those used in the current stage of the ARIES-I tokamak reactor study. Typical reactor parameters for a 1-GW(e) Compact Torsatron reactor example are major radius R[sub 0] = 6.6-8.8 m, on-axis magnetic field B[sup 0] = 4.8-7.5 T, B[sub max] (on coils) = 16 T, MUE 140-210 kW(e)/tonne, and COE (in constant 1990 dollars) = 67-79 mill/kW(e)h. The results are relatively sensitive to assumptions on the level of confinement improvement and the blanket thickness under the inboard half of the helical windings but relatively insensitive to other assumptions.

  15. Transcranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): a cross-sectional study.

    PubMed

    Pedroso, José Luiz; Bor-Seng-Shu, Edson; Felício, Andre Carvalho; Braga-Neto, Pedro; Teixeira, Manoel Jacobsen; Barsottini, Orlando Graziani

    2011-10-24

    Few studies on transcranial brain sonography have been performed in hereditary and non-hereditary ataxias. The objective of the present study was to report transcranial brain sonography findings in a sample of clinically and molecularly proven Machado-Joseph disease patients and to compare these data against those of an age- and gender-matched control group. A cross-sectional study on transcranial brain sonography was conducted in 30 Machado-Joseph disease patients. Transcranial brain sonography was performed by an experienced sonographer blinded to the clinical, genetic, and neuroimaging data. The results were compared with those of a control group of 44 healthy subjects matched for age and gender. The sonographic findings were also correlated with clinical features and genetic data in Machado-Joseph disease group. A significantly higher frequency of substantia nigra and lenticular nucleus hyperechogenicity was found in the Machado-Joseph disease group compared to an age- and gender-matched healthy control group (p<0.001). The substantia nigra echogenic area proved to be the best predictor for differentiating cases from controls. Third and lateral ventricles were significantly larger in the Machado-Joseph disease patients than in the control subjects. No significant correlations were found between transcranial brain sonography findings and Machado-Joseph disease demographic/clinical data. Transcranial brain sonography findings in Machado-Joseph disease patients differed significantly to those in age- and gender-matched controls. Substantia nigra hyperechogenicity occurred frequently in Machado-Joseph disease patients and was found to be the best predictor for differentiating cases from controls. Additionally, this data describes the occurrence of brain atrophy in Machado-Joseph disease group. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  16. Control Means for Reactor

    DOEpatents

    Manley, J. H.

    1961-06-27

    An apparatus for controlling a nuclear reactor includes a tank just below the reactor, tubes extending from the tank into the reactor, and a thermally expansible liquid neutron absorbent material in the tank. The liquid in the tank is exposed to a beam of neutrons from the reactor which heats the liquid causing it to expand into the reactor when the neutron flux in the reactor rises above a predetermincd danger point. Boron triamine may be used for this purpose.

  17. NEUTRONIC REACTOR

    DOEpatents

    Stewart, H.B.

    1958-12-23

    A nuclear reactor of the type speclfically designed for the irradiation of materials is discussed. In this design a central cyllndrical core of moderating material ls surrounded by an active portlon comprlsed of an annular tank contalning fissionable material immersed ln a liquid moderator. The active portion ls ln turn surrounded by a reflector, and a well ls provided in the center of the core to accommodate the materlals to be irradiated. The over-all dimensions of the core ln at least one plane are equal to or greater than twice the effective slowing down length and equal to or less than twlce the effective diffuslon length for neutrons in the core materials.

  18. NEUTRONIC REACTOR

    DOEpatents

    Daniels, F.

    1962-12-18

    A power plant is described comprising a turbine and employing round cylindrical fuel rods formed of BeO and UO/sub 2/ and stacks of hexagonal moderator blocks of BeO provided with passages that loosely receive the fuel rods so that coolant may flow through the passages over the fuels to remove heat. The coolant may be helium or steam and fiows through at least one more heat exchanger for producing vapor from a body of fluid separate from the coolant, which fluid is to drive the turbine for generating electricity. By this arrangement the turbine and directly associated parts are free of particles and radiations emanating from the reactor. (AEC)

  19. NEUTRONIC REACTOR

    DOEpatents

    McGarry, R.J.

    1958-04-22

    Fluid-cooled nuclear reactors of the type that utilize finned uranium fuel elements disposed in coolant channels in a moderater are described. The coolant channels are provided with removable bushings composed of a non- fissionable material. The interior walls of the bushings have a plurality of spaced, longtudinal ribs separated by grooves which receive the fins on the fuel elements. The lands between the grooves are spaced from the fuel elements to form flow passages, and the size of the now passages progressively decreases as the dlstance from the center of the core increases for the purpose of producing a greater cooling effect at the center to maintain a uniform temperature throughout the core.

  20. Nuclear reactor neutron shielding

    DOEpatents

    Speaker, Daniel P; Neeley, Gary W; Inman, James B

    2017-09-12

    A nuclear reactor includes a reactor pressure vessel and a nuclear reactor core comprising fissile material disposed in a lower portion of the reactor pressure vessel. The lower portion of the reactor pressure vessel is disposed in a reactor cavity. An annular neutron stop is located at an elevation above the uppermost elevation of the nuclear reactor core. The annular neutron stop comprises neutron absorbing material filling an annular gap between the reactor pressure vessel and the wall of the reactor cavity. The annular neutron stop may comprise an outer neutron stop ring attached to the wall of the reactor cavity, and an inner neutron stop ring attached to the reactor pressure vessel. An excore instrument guide tube penetrates through the annular neutron stop, and a neutron plug comprising neutron absorbing material is disposed in the tube at the penetration through the neutron stop.

  1. Summary Describing Integration of ERM Methodology into Supervisory Control Framework with Software Package Documentation; Advanced Reactor Technology Milestone: M4AT-16PN2301052

    SciTech Connect

    Ramuhalli, Pradeep; Hirt, Evelyn H.; Dib, Gerges; Veeramany, Arun; Bonebrake, Christopher A.; Roy, Surajit

    2016-09-20

    This project involved the development of enhanced risk monitors (ERMs) for active components in Advanced Reactor (AdvRx) designs by integrating real-time information about equipment condition with risk monitors. Health monitoring techniques in combination with predictive estimates of component failure based on condition and risk monitors can serve to indicate the risk posed by continued operation in the presence of detected degradation. This combination of predictive health monitoring based on equipment condition assessment and risk monitors can also enable optimization of maintenance scheduling with respect to the economics of plant operation. This report summarizes PNNL’s multi-year project on the development and evaluation of an ERM concept for active components while highlighting FY2016 accomplishments. Specifically, this report provides a status summary of the integration and demonstration of the prototypic ERM framework with the plant supervisory control algorithms being developed at Oak Ridge National Laboratory (ORNL), and describes additional case studies conducted to assess sensitivity of the technology to different quantities. Supporting documentation on the software package to be provided to ONRL is incorporated in this report.

  2. Reactor and method of operation

    DOEpatents

    Wheeler, John A.

    1976-08-10

    A nuclear reactor having a flattened reactor activity curve across the reactor includes fuel extending over a lesser portion of the fuel channels in the central portion of the reactor than in the remainder of the reactor.

  3. Nuclear reactor

    DOEpatents

    Yant, Howard W.; Stinebiser, Karl W.; Anzur, Gregory C.

    1977-01-01

    A nuclear reactor, particularly a liquid-metal breeder reactor, whose upper internals include outlet modules for channeling the liquid-metal coolant from selected areas of the outlet of the core vertically to the outlet plenum. The modules are composed of a highly-refractory, high corrosion-resistant alloy, for example, INCONEL-718. Each module is disposed to confine and channel generally vertically the coolant emitted from a subplurality of core-component assemblies. Each module has a grid with openings, each opening disposed to receive the coolant from an assembly of the subplurality. The grid in addition serves as a holdown for the assemblies of the corresponding subplurality preventing their excessive ejection upwardly from the core. In the region directly over the core the outlet modules are of such peripheral form that they nest forming a continuum over the core-component assemblies whose outlet coolant they confine. Each subassembly includes a chimney which confines the coolant emitted by its corresponding subassemblies to generally vertical flow between the outlet of the core and the outlet plenum. Each subplurality of assemblies whose emitted coolant is confined by an outlet module includes assemblies which emit lower-temperature coolant, for example, a control-rod assembly, or fertile assemblies, and assemblies which emit coolant of substantially higher temperature, for example, fuel-rod assemblies. The coolants of different temperatures are mixed in the chimneys reducing the effect of stripping (hot-cold temperature fluctuations) on the remainder of the upper internals which are composed typically of AISI-304 or AISI-316 stainless steel.

  4. Complete genome analysis of Clostridium bornimense strain M2/40(T): A new acidogenic Clostridium species isolated from a mesophilic two-phase laboratory-scale biogas reactor.

    PubMed

    Tomazetto, Geizecler; Hahnke, Sarah; Koeck, Daniela E; Wibberg, Daniel; Maus, Irena; Pühler, Alfred; Klocke, Michael; Schlüter, Andreas

    2016-08-20

    Taxonomic and functional profiling based on metagenome analyses frequently revealed that members of the class Clostridia dominate biogas reactor communities and perform different essential metabolic pathways in the biogas fermentation process. Clostridium bornimense strain M2/40(T) was recently isolated from a mesophilic two-phase lab-scale biogas reactor continuously fed with maize silage and wheat straw. The genome of the strain was completely sequenced and manually annotated to reconstruct its metabolic potential regarding carbohydrate active enzyme production and fermentation of organic compounds for consolidated biofuel production from biomass. The C. bornimense M2/40(T) genome consists of a chromosome (2,917,864bp in size) containing 2613 protein coding sequences, and a 699,161bp chromid (secondary replicon) harboring 680 coding sequences. Both replicons feature very similar GC-contents of approximately 29%. The complex genome comprises three prophage regions, two CRISPR-cas systems and a putative cellulosomal gene cluster that is located on the second replicon (chromid) of the strain. The overexpressed glycosyl hydrolases (GH) CelK (GH9) and CelA (GH48) encoded in the cellulosomal gene cluster were shown to be active on the substrates xylan and xyloglucan whereas XghA (GH74) is highly active on xyloglucan. Reconstruction of fermentation pathways from genome sequence data revealed that strain M2/40(T) encodes all enzymes for hydrogen, acetate, formate, lactate, butyrate, and ethanol production, leading to the classification of the isolate as acidogenic bacterium. Phylogenetic analyses uncovered that the closest characterized relative of C. bornimense is C. cellulovorans. Comparative analyses of the C. bornimense and C. cellulovorans genomes revealed considerable rearrangements within their chromosomes suggesting that both species evolved separately for a relatively long period of time and adapted to specific tasks within microbial consortia responsible for

  5. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

    PubMed

    Teixeira-Castro, Andreia; Jalles, Ana; Esteves, Sofia; Kang, Soosung; da Silva Santos, Liliana; Silva-Fernandes, Anabela; Neto, Mário F; Brielmann, Renée M; Bessa, Carlos; Duarte-Silva, Sara; Miranda, Adriana; Oliveira, Stéphanie; Neves-Carvalho, Andreia; Bessa, João; Summavielle, Teresa; Silverman, Richard B; Oliveira, Pedro; Morimoto, Richard I; Maciel, Patrícia

    2015-11-01

    Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease.

  6. [Joseph Willot, pharmacist, and his fighter activities during the 1st war].

    PubMed

    Bonnemain, Bruno

    2008-05-01

    Joseph Willot was pharmacist (PhD), professor of pharmaceutical chemistry at the Catholic University of Lille (France), but also pharmacist in town and industrial pharmacist. Born in 1876, he was invited by Firmin Dubar, business man from Roubaix, and Mr Pinte, priest and teacher of chemistry at the technical Institute in the same town, to joint them in 1914, under the German Occupation, in order to diffuse information from the free part of France. This diffusion is going very soon to be under the format of an underground journal which had several successive names (L'Oiseau de France, La Patience...) until the network was discovered in 1916. Joseph Willot and his two partners were then deported in Germany. The present article wants to remind the history of this pharmacist from the professional viewpoint as well as for his fighter activities and his influence later on.

  7. Joseph Hersey Pratt (1872-1956): An early proponent of cognitive-behavioural therapy in America.

    PubMed

    Ambrose, Charles T

    2014-02-01

    The treatment of mild psychoneuroses in America began shifting in the 1950s from Freudian psychoanalysis to various forms of psychotherapy that do not delve into patient's subconscious. Some of the new approaches were termed cognitive, behavioural or cognitive behavioural therapy and in America were practised notably by Joseph Wolpe, Albert Ellis and Aaron T Beck. Modern psychiatric literature makes little mention of two prior innovators in this area - the French neurologist Jules Dejerine and his Boston disciple Joseph H Pratt. In the early 1900s, Dejerine treated patients at La Salpêtrière in Paris using techniques adopted subsequently by Pratt during the 1930s and employed by the trio some decades later. This paper revisits the early history of psychotherapy in America and includes a brief summary of Pratt's medical career.

  8. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

    PubMed Central

    Teixeira-Castro, Andreia; Kang, Soosung; da Silva Santos, Liliana; Silva-Fernandes, Anabela; Neto, Mário F.; Brielmann, Renée M.; Bessa, Carlos; Duarte-Silva, Sara; Miranda, Adriana; Oliveira, Stéphanie; Neves-Carvalho, Andreia; Bessa, João; Summavielle, Teresa; Silverman, Richard B.; Oliveira, Pedro; Morimoto, Richard I.

    2015-01-01

    Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease. PMID:26373603

  9. Reactor safety method

    DOEpatents

    Vachon, Lawrence J.

    1980-03-11

    This invention relates to safety means for preventing a gas cooled nuclear reactor from attaining criticality prior to start up in the event the reactor core is immersed in hydrogenous liquid. This is accomplished by coating the inside surface of the reactor coolant channels with a neutral absorbing material that will vaporize at the reactor's operating temperature.

  10. Wildlife Habitat Impact Assessment, Chief Joseph Dam Project, Washington : Project Report 1992.

    SciTech Connect

    Kuehn, Douglas; Berger, Matthew

    1992-01-01

    Under the Pacific Northwest Electric Power Planning and Conservation Act of 1980, and the subsequent Northwest Power Planning Council`s Columbia River Basin Fish and Wildlife Program, a wildlife habitat impact assessment and identification of mitigation objectives have been developed for the US Army Corps of Engineer`s Chief Joseph Dam Project in north-central Washington. This study will form the basis for future mitigation planning and implementation.

  11. Asian origin for the worldwide-spread mutational event in Machado-Joseph disease.

    PubMed

    Martins, Sandra; Calafell, Francesc; Gaspar, Claudia; Wong, Virginia C N; Silveira, Isabel; Nicholson, Garth A; Brunt, Ewout R; Tranebjaerg, Lisbeth; Stevanin, Giovanni; Hsieh, Mingli; Soong, Bing-Wen; Loureiro, Leal; Dürr, Alexandra; Tsuji, Shoji; Watanabe, Mitsunori; Jardim, Laura B; Giunti, Paola; Riess, Olaf; Ranum, Laura P W; Brice, Alexis; Rouleau, Guy A; Coutinho, Paula; Amorim, António; Sequeiros, Jorge

    2007-10-01

    Machado-Joseph disease is the most frequent dominant ataxia worldwide. Despite its frequency and presence in many populations, only 2 founder mutations have been suggested to explain its current geographic distribution. To trace back in history the main mutational events in Machado-Joseph disease, we aimed to assess ancestral haplotypes and population backgrounds, to date the mutations, and to trace the routes and time of introduction of the founder haplotypes in different populations. We studied 264 families with Machado-Joseph disease from 20 different populations. Six intragenic single-nucleotide polymorphisms were used to determine ancestral mutational events; 4 flanking short tandem repeats were used to construct extended haplotypes and measure accumulation of genetic diversity over time within each lineage. The worldwide-spread lineage, TTACAC, had its highest diversity in the Japanese population, where we identified the ancestral short tandem repeat-based haplotype. Accumulated variability suggested a postneolithic mutation, about 5774 +/- 1116 years old, with more recent introductions in North America, Germany, France, Portugal, and Brazil. As to the second mutational event, in the GTGGCA lineage, only 7 families (of 71 families) did not have Portuguese ancestry, although gene diversity was again smaller in Portuguese families (0.44) than in non-Portuguese families (0.93). The worldwide-spread mutation may have first occurred in Asia and later been diffused throughout Europe, with a founder effect accounting for its high prevalence in Portugal; the other Machado-Joseph disease lineage is more recent, about 1416 +/- 434 years old, and its dispersion may be explained mainly by recent Portuguese emigration.

  12. Archaeological Investigations at Site 45-OK-258, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1985-01-01

    neceeeary and Identify by block number) Cultural Resources, Washington Frenchman Springs Phase Columbia River rrehistory Cayuse Phase Chief Joseph Dam... Cryptocrystalline (CCS) materials, including jasper, chalcedony, petrified wood, and opal, make up slightly over 80% of all artifacts, and quartzite objects...of them were of cryptocrystalline - - material, while roughly 50% of the debitage was coarse quartzite. This distinguishes this bone layer from that of

  13. Archaeological Investigations at Site 45-DO-282, Chief Joseph Dam Project, Washington

    DTIC Science & Technology

    1984-01-01

    Columbia River rrehistory Cascade Phase Chief Joseph Dam Project Archaeology Frenchman Springs Phase Settlement and Subsistence Patterns Southern...majority of object types with cortex are cryptocrystalline concholdal flakes (73%) (Table 3-10). Cryptocrystaillne chunks comprise 5.7% and non...object types. Weight, length, thickness and weight measurements taken on concholdal flakes reflect the use of cryptocrystalline stones for most tool forms

  14. Archaeological Investigations at Sites 45-OK-250 and 45-OK-4, Chief Joseph Dam Project, Washington.

    DTIC Science & Technology

    1984-01-01

    River rrehistory Frenchman Springs Phase Chief Jos.eph Dam Project Archaeology Archaeobotany Settlement and Subsistence Patterns Nespelem Indians... Cryptocrystalline artifacts by zone, 45-OK-250 and 45-OK-4 .. .... ......... ......... .... 55 Table 3-4. Quartz ite arti facts by zone, 45-OK-250 and... Cryptocrystalline artifacts by zone, 45-OK-250 and 45-OK-4. 274 Table B-4. Quartzite artifacts by zone, 45-OK-250 and 45-OK-4 .. .. ... 276 Table B-5. Basalt

  15. Arthur Conan Doyle, Joseph Bell, and Sherlock Holmes. A neurologic connection.

    PubMed

    Westmoreland, B F; Key, J D

    1991-03-01

    Neurologists, like physicians in several other medical specialties, can lay claim to Sherlock Holmes as one of their own. This assertion is validated by the number of neurologic conditions, such as seizures, stroke, syncope, encephalopathies, and head trauma, that are mentioned in the stories and novels. In addition, the article reviews the powers of observation and the deductive approach utilized by Conan Doyle and Joseph Bell, the models for Sherlock Holmes, and how these skills can be applied to medical problems.

  16. Astronaut Joseph P. Allen, STS-5 crew member, in front of open hatch

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Astronaut Joseph P. Allen, right, STS-5 mission specialist, slips on jacket portion of his Shuttle constant-wear garment in the White room at Launch Pad 39A at the Kennedy Space Center (KSC). Astronaut William B. Lenoir, STS-5's other mission specialist, left, waits to enter the Columbia, whose open hatch is at center. Electrodes on Allen's face and head are for monitoring his reflexes during launch.

  17. Astronaut Joseph Kerwin during EVA at Skylab 1 and 2 space station cluster

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin, Skylab 2 science pilot, performs extravehicular activity (EVA) at the Skylab 1 and 2 space station cluster in Earth orbit, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the station. Kerwin is just outside the Airlock Module. Kerwin assisted Astronaut Charles Conrad Jr., Skylab 2 commander, during the successful EVA attempt to free the stuck solar array system wing on the Orbital Workshop.

  18. Irish links of the multinational chemist Joseph Black (1728-1799).

    PubMed

    Breathnach, C S

    1999-10-01

    Joseph Black (1728-1799) is remembered for his discovery of carbon dioxide and his characterisation of latent heat and specific heat. He was a chemist by chance, a physicist by inclination, and a physician by necessity. His discovery of carbon dioxide was as important for biology as it was for chemistry, and his work on heat laid a sound foundation for the study of temperature regulation in man and animals.

  19. The Life and Work of Joseph Plateau: Father of Film and Discoverer of Surface Tension

    NASA Astrophysics Data System (ADS)

    Wautier, Kristel; Jonckheere, Alexander; Segers, Danny

    2012-09-01

    In 1835 Joseph Plateau (1801-1883) was appointed Professor of Physics and Applied Physics at Ghent University, Belgium. By then he was well known for his groundbreaking work on the aftereffect of light on the human retina, and he would go on to become the first person to produce moving images, for which he is considered to be the Father of Film. His greatest scientific achievement, however, was his discovery of surface tension.

  20. Explosive demolition of K East Reactor Stack

    ScienceCinema

    None

    2016-07-12

    Using $420,000 in Recovery Act funds, the Department of Energy and contractor CH2M HILL Plateau Remediation Company topped off four months of preparations when they safely demolished the exhaust stack at the K East Reactor and equipment inside the reactor building on July 23, 2010.

  1. Explosive demolition of K East Reactor Stack

    SciTech Connect

    2010-07-26

    Using $420,000 in Recovery Act funds, the Department of Energy and contractor CH2M HILL Plateau Remediation Company topped off four months of preparations when they safely demolished the exhaust stack at the K East Reactor and equipment inside the reactor building on July 23, 2010.

  2. Machado–Joseph disease in a Nigerian family: mutational origin and review of the literature

    PubMed Central

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-01-01

    Machado–Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years. PMID:24781759

  3. Machado-Joseph disease in a Nigerian family: mutational origin and review of the literature.

    PubMed

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-02-01

    Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years.

  4. Nuclear reactor

    DOEpatents

    Thomson, Wallace B.

    2004-03-16

    A nuclear reactor comprising a cylindrical pressure vessel, an elongated annular core centrally disposed within and spaced from the pressure vessel, and a plurality of ducts disposed longitudinally of the pressure vessel about the periphery thereof, said core comprising an annular active portion, an annular reflector just inside the active portion, and an annular reflector just outside the active a portion, said annular active portion comprising rectangular slab, porous fuel elements radially disposed around the inner reflector and extending the length of the active portion, wedge-shaped, porous moderator elements disposed adjacent one face of each fuel element and extending the length of the fuel element, the fuel and moderator elements being oriented so that the fuel elements face each other and the moderator elements do likewise, adjacent moderator elements being spaced to provide air inlet channels, and adjacent fuel elements being spaced to provide air outlet channels which communicate with the interior of the peripheral ducts, and means for introducing air into the air inlet channels which passes through the porous moderator elements and porous fuel elements to the outlet channel.

  5. Experiment for search for sterile neutrino at SM-3 reactor

    NASA Astrophysics Data System (ADS)

    Serebrov, A. P.; Ivochkin, V. G.; Samoylov, R. M.; Fomin, A. K.; Zinoviev, V. G.; Neustroev, P. V.; Golovtsov, V. L.; Gruzinsky, N. V.; Solovey, V. A.; Cherniy, A. V.; Zherebtsov, O. M.; Martemyanov, V. P.; Zinoev, V. G.; Tarasenkov, V. G.; Aleshin, V. I.; Petelin, A. L.; Pavlov, S. V.; Izhutov, A. L.; Sazontov, S. A.; Ryazanov, D. K.; Gromov, M. O.; Afanasiev, V. V.; Matrosov, L. N.; Matrosova, M. Yu.

    2016-11-01

    In connection with the question of possible existence of sterile neutrino the laboratory on the basis of SM-3 reactor was created to search for oscillations of reactor antineutrino. A prototype of a neutrino detector with scintillator volume of 400 l can be moved at the distance of 6-11 m from the reactor core. The measurements of background conditions have been made. It is shown that the main experimental problem is associated with cosmic radiation background. Test measurements of dependence of a reactor antineutrino flux on the distance from a reactor core have been made. The prospects of search for oscillations of reactor antineutrino at short distances are discussed.

  6. Skin Injuries Reduce Survival and Modulate Corticosterone, C-Reactive Protein, Complement Component 3, IgM, and Prostaglandin E2 after Whole-Body Reactor-Produced Mixed Field (n + γ-Photons) Irradiation

    PubMed Central

    Kiang, Juliann G.; Ledney, G. David

    2013-01-01

    Skin injuries such as wounds or burns following whole-body γ-irradiation (radiation combined injury (RCI)) increase mortality more than whole-body γ-irradiation alone. Wound-induced decreases in survival after irradiation are triggered by sustained activation of inducible nitric oxide synthase pathways, persistent alteration of cytokine homeostasis, and increased susceptibility to systemic bacterial infection. Among these factors, radiation-induced increases in interleukin-6 (IL-6) concentrations in serum were amplified by skin wound trauma. Herein, the IL-6-induced stress proteins including C-reactive protein (CRP), complement 3 (C3), immunoglobulin M (IgM), and prostaglandin E2 (PGE2) were evaluated after skin injuries given following a mixed radiation environment that might be found after a nuclear incident. In this report, mice received 3 Gy of reactor-produced mixed field (n + γ-photons) radiations at 0.38 Gy/min followed by nonlethal skin wounding or burning. Both wounds and burns reduced survival and increased CRP, C3, and PGE2 in serum after radiation. Decreased IgM production along with an early rise in corticosterone followed by a subsequent decrease was noted for each RCI situation. These results suggest that RCI-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival. Agents inhibiting these responses may prove to be therapeutic for RCI and improve related survival. PMID:24175013

  7. Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation.

    PubMed

    Kiang, Juliann G; Ledney, G David

    2013-01-01

    Skin injuries such as wounds or burns following whole-body γ-irradiation (radiation combined injury (RCI)) increase mortality more than whole-body γ-irradiation alone. Wound-induced decreases in survival after irradiation are triggered by sustained activation of inducible nitric oxide synthase pathways, persistent alteration of cytokine homeostasis, and increased susceptibility to systemic bacterial infection. Among these factors, radiation-induced increases in interleukin-6 (IL-6) concentrations in serum were amplified by skin wound trauma. Herein, the IL-6-induced stress proteins including C-reactive protein (CRP), complement 3 (C3), immunoglobulin M (IgM), and prostaglandin E2 (PGE2) were evaluated after skin injuries given following a mixed radiation environment that might be found after a nuclear incident. In this report, mice received 3 Gy of reactor-produced mixed field (n + γ-photons) radiations at 0.38 Gy/min followed by nonlethal skin wounding or burning. Both wounds and burns reduced survival and increased CRP, C3, and PGE2 in serum after radiation. Decreased IgM production along with an early rise in corticosterone followed by a subsequent decrease was noted for each RCI situation. These results suggest that RCI-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival. Agents inhibiting these responses may prove to be therapeutic for RCI and improve related survival.

  8. Water quality and discharge data for St. Joseph Bay, Florida, 1997-98

    USGS Publications Warehouse

    Berndt, M.P.; Franklin, M.A.

    1999-01-01

    Historical data were compiled on water quality and water levels for the St. Joseph Bay area to assess quality of possible sources of land-derived water into the Bay. Ground-water quality data were compiled from Florida Department of Environmental Protection and surface-water quality data were compiled from U.S.Geological Survey files. Water-quality and water-level data were measured during two sample collection periods in October 1997 and March 1998 to determine water-quality and discharge rates in St. Joseph Bay under two sets of flow conditions. Measurements in the Bay included water level, temperature, pH, specific conductance, dissolved oxygen, and turbidity. Median pH in water from the surficial, intermediate and Floridan aquifer systems ranged from 4.8 to 7.8, and median specific conductance values were less than 500 microsiemens per centimeter. Median nutrient concentrations-- nitrate plus nitrite, ammonia and phosphorus--in the three aquifers were less than 0.5 milligrams per liter. The median pH was 7.0 and the median specific conductance was 81 microsiemens per centimeter for two samples from the Chipola River distribution canal. Water level data were obtained for several wells near St. Joseph Bay but only two wells yielded sufficient data to plot hydrographs. Measurements in St. Joseph Bay during the October and March collection periods were similar for pH and turbidity but differed for temperature, specific conductance and dissolved oxygen. The median temperature was 20.6 degrees Celsius in October and 15.4 degrees Celsius in March, median specific conductance was 39,500 microsiemens per centimeter in October and 43,300 microsiemens per centimeter in March, and median dissolved oxygen was 7.6 milligrams per liter in October and 8.3 milligrams per liter in March. The range in water levels over a tidal cycle in St. Joseph Bay on October 29, 1997 was about 1 foot. During a 24-hour tidal cycle on October 29, 1997, estimated hourly discharge varied from

  9. Accelerator based fusion reactor

    NASA Astrophysics Data System (ADS)

    Liu, Keh-Fei; Chao, Alexander Wu

    2017-08-01

    A feasibility study of fusion reactors based on accelerators is carried out. We consider a novel scheme where a beam from the accelerator hits the target plasma on the resonance of the fusion reaction and establish characteristic criteria for a workable reactor. We consider the reactions d+t\\to n+α,d+{{}3}{{H}\\text{e}}\\to p+α , and p+{{}11}B\\to 3α in this study. The critical temperature of the plasma is determined from overcoming the stopping power of the beam with the fusion energy gain. The needed plasma lifetime is determined from the width of the resonance, the beam velocity and the plasma density. We estimate the critical beam flux by balancing the energy of fusion production against the plasma thermo-energy and the loss due to stopping power for the case of an inert plasma. The product of critical flux and plasma lifetime is independent of plasma density and has a weak dependence on temperature. Even though the critical temperatures for these reactions are lower than those for the thermonuclear reactors, the critical flux is in the range of {{10}22}-{{10}24}~\\text{c}{{\\text{m}}-2}~{{\\text{s}}-1} for the plasma density {ρt}={{10}15}~\\text{c}{{\\text{m}}-3} in the case of an inert plasma. Several approaches to control the growth of the two-stream instability are discussed. We have also considered several scenarios for practical implementation which will require further studies. Finally, we consider the case where the injected beam at the resonance energy maintains the plasma temperature and prolongs its lifetime to reach a steady state. The equations for power balance and particle number conservation are given for this case.

  10. Continuous steroid biotransformations in microchannel reactors.

    PubMed

    Marques, Marco P C; Fernandes, Pedro; Cabral, Joaquim M S; Znidaršič-Plazl, Polona; Plazl, Igor

    2012-01-15

    The use of microchannel reactor based technologies within the scope of bioprocesses as process intensification and production platforms is gaining momentum. Such trend can be ascribed a particular set of characteristics of microchannel reactors, namely the enhanced mass and heat transfer, combined with easier handling and smaller volumes required, as compared to traditional reactors. In the present work, a continuous production process of 4-cholesten-3-one by the enzymatic oxidation of cholesterol without the formation of any by-product was assessed. The production was carried out within Y-shaped microchannel reactors in an aqueous-organic two-phase system. Substrate was delivered from the organic phase to aqueous phase containing cholesterol oxidase and the product formed partitions back to the organic phase. The aqueous phase was then forced through a plug-flow reactor, containing immobilized catalase. This step aimed at the reduction of hydrogen peroxide formed as a by-product during cholesterol oxidation, to avoid cholesterol oxidase deactivation due to said by-product. This setup was compared with traditional reactors and modes of operation. The results showed that microchannel reactor geometry outperformed traditional stirred tank and plug-flow reactors reaching similar conversion yields at reduced residence time. Coupling the plug-flow reactor containing catalase enabled aqueous phase reuse with maintenance of 30% catalytic activity of cholesterol oxidase while eliminating hydrogen peroxide. A final production of 36 m of cholestenone was reached after 300 hours of operation.

  11. ATFSR: a small torsatron reactor

    SciTech Connect

    Houlberg, W.A.; Lacatski, J.T.; Uckan, N.A.

    1985-01-01

    A small (average minor radius anti a approx. = 1 m), moderate-aspect-ratio torsatron reactor based on the Advanced Toroidal Facility (ATF) is proposed as a starting point for improved stellarator reactor designs. The major limitation of the compact size is the lack of space under the helical coils for the blanket and shield. Neoclassical confinement models for helically trapped particles show that a large electric potential (radial electric field) is necessary to achieve ignition in a device of this size, although high-Q operation is still attainable with more modest potentials.

  12. Tokamak reactor studies

    SciTech Connect

    Baker, C.C.

    1981-01-01

    This paper presents an overview of tokamak reactor studies with particular attention to commercial reactor concepts developed within the last three years. Emphasis is placed on DT fueled reactors for electricity production. A brief history of tokamak reactor studies is presented. The STARFIRE, NUWMAK, and HFCTR studies are highlighted. Recent developments that have increased the commercial attractiveness of tokamak reactor designs are discussed. These developments include smaller plant sizes, higher first wall loadings, improved maintenance concepts, steady-state operation, non-divertor particle control, and improved reactor safety features.

  13. The Story of Joseph from the Koran. Lessons from ORIAS Institute on History through Literature in the 6th Grade/7th Grade Core Classrooms, 1998-2000.

    ERIC Educational Resources Information Center

    Michalak, Laurence

    This lesson about Islam and the Koran is intended for grade 6 or 7 core classrooms. The lesson plan uses the story of Joseph (not Joseph, the father of Jesus, but Joseph who was abandoned by his brothers in a pit) as told in the Koran. The lesson plan does not provide a translation of the story but indicates where one can be found on the Internet.…

  14. Antineutrino monitoring of thorium reactors

    NASA Astrophysics Data System (ADS)

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-01

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg of 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. A rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.

  15. Antineutrino monitoring of thorium reactors

    SciTech Connect

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-30

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg of 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. In conclusion, a rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.

  16. Antineutrino monitoring of thorium reactors

    DOE PAGES

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-30

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg ofmore » 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. In conclusion, a rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.« less

  17. Antineutrino monitoring of thorium reactors

    SciTech Connect

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-30

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg of 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. In conclusion, a rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.

  18. Antineutrino monitoring of thorium reactors

    SciTech Connect

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-28

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg of 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. A rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.

  19. Antineutrino monitoring of thorium reactors

    DOE PAGES

    Akindele, Oluwatomi A.; Bernstein, Adam; Norman, Eric B.

    2016-09-28

    Various groups have demonstrated that antineutrino monitoring can be successful in assessing the plutonium content in water-cooled nuclear reactors for nonproliferation applications. New reactor designs and concepts incorporate nontraditional fuel types and chemistry. Understanding how these properties affect the antineutrino emission from a reactor can extend the applicability of antineutrino monitoring. Thorium molten salt reactors breed 233U, that if diverted constitute a direct use material as defined by the International Atomic Energy Agency (IAEA). The antineutrino spectrum from the fission of 233U has been estimated for the first time, and the feasibility of detecting the diversion of 8 kg ofmore » 233U, within a 30 day timeliness goal has been evaluated. The antineutrino emission from a thorium reactor operating under normal conditions is compared to a diversion scenario by evaluating the daily antineutrino count rate and the energy spectrum of the detected antineutrinos at a 25 m standoff. It was found that the diversion of a significant quantity of 233U could not be detected within the current IAEA timeliness detection goal using either tests. A rate-time based analysis exceeded the timeliness goal by 23 days, while a spectral based analysis exceeds this goal by 31 days.« less

  20. Characterization and application of a miniature 10 mL stirred-tank bioreactor, showing scale-down equivalence with a conventional 7 L reactor.

    PubMed

    Betts, Jonathan I; Doig, Steven D; Baganz, Frank

    2006-01-01

    The aim of this study was to characterize the engineering environment of an instrumented 10 mL miniature stirred-tank bioreactor and evaluate its potential as a scale-down device for microbial fermentation processes. Miniature bioreactors such as the one detailed in this work have been developed by several research groups and companies and seek to address the current bottleneck at the screening stage of bioprocess development. The miniature bioreactor was characterized in terms of overall volumetric oxygen transfer coefficient and mixing time over a wide range of impeller speeds. Power input to the miniature bioreactor was directly measured, and from this the power number of each impeller was calculated and specific power input estimated, allowing the performance of the miniature bioreactor to be directly compared with that of a conventional 7 L bioreactor. The capability of the miniature bioreactor to carry out microbial fermentations was also investigated. Replicate batch fermentations of Escherichia coli DH5alpha producing plasmid DNA were performed at equal specific power input, under fully aerobic and oxygen-limiting conditions. The results showed a high degree of equivalence between the two scales with regard to growth and product kinetics. This was underlined by the equal maximum specific growth rate and equal specific DNA product yield on biomass obtained at the two scales of operation, demonstrating the feasibility of scaling down to 10 mL on the basis of equivalent specific power input.

  1. Hybrid plasmachemical reactor

    SciTech Connect

    Lelevkin, V. M. Smirnova, Yu. G.; Tokarev, A. V.

    2015-04-15

    A hybrid plasmachemical reactor on the basis of a dielectric barrier discharge in a transformer is developed. The characteristics of the reactor as functions of the dielectric barrier discharge parameters are determined.

  2. Attrition reactor system

    SciTech Connect

    Scott, Charles D.; Davison, Brian H.

    1993-01-01

    A reactor vessel for reacting a solid particulate with a liquid reactant has a centrifugal pump in circulatory flow communication with the reactor vessel for providing particulate attrition, resulting in additional fresh surface where the reaction can occur.

  3. Attrition reactor system

    SciTech Connect

    Scott, C.D.; Davison, B.H.

    1993-09-28

    A reactor vessel for reacting a solid particulate with a liquid reactant has a centrifugal pump in circulatory flow communication with the reactor vessel for providing particulate attrition, resulting in additional fresh surface where the reaction can occur. 2 figures.

  4. Period meter for reactors

    DOEpatents

    Rusch, Gordon K.

    1976-01-06

    An improved log N amplifier type nuclear reactor period meter with reduced probability for noise-induced scrams is provided. With the reactor at low power levels a sampling circuit is provided to determine the reactor period by measuring the finite change in the amplitude of the log N amplifier output signal for a predetermined time period, while at high power levels, differentiation of the log N amplifier output signal provides an additional measure of the reactor period.

  5. NEUTRONIC REACTOR POWER PLANT

    DOEpatents

    Metcalf, H.E.

    1962-12-25

    This patent relates to a nuclear reactor power plant incorporating an air-cooled, beryllium oxide-moderated, pebble bed reactor. According to the invention means are provided for circulating a flow of air through tubes in the reactor to a turbine and for directing a sidestream of the circu1ating air through the pebble bed to remove fission products therefrom as well as assist in cooling the reactor. (AEC)

  6. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.

    PubMed

    Nascimento-Ferreira, Isabel; Santos-Ferreira, Tiago; Sousa-Ferreira, Lígia; Auregan, Gwennaëlle; Onofre, Isabel; Alves, Sandro; Dufour, Noëlle; Colomer Gould, Veronica F; Koeppen, Arnulf; Déglon, Nicole; Pereira de Almeida, Luís

    2011-05-01

    Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 misfolding, intracellular accumulation of aggregates and neuronal degeneration. Here we investigated the implication of autophagy, the major pathway for organelle and protein turnover, in the accumulation of mutant ataxin-3 aggregates and neurodegeneration found in Machado-Joseph disease and we assessed whether specific stimulation of this pathway could mitigate the disease. Using tissue from patients with Machado-Joseph disease, transgenic mice and a lentiviral-based rat model, we found an abnormal expression of endogenous autophagic markers, accumulation of autophagosomes and decreased levels of beclin-1, a crucial protein in the early nucleation step of autophagy. Lentiviral vector-mediated overexpression of beclin-1 led to stimulation of autophagic flux, mutant ataxin-3 clearance and overall neuroprotective effects in neuronal cultures and in a lentiviral-based rat model of Machado-Joseph disease. These data demonstrate that autophagy is a key degradation pathway, with beclin-1 playing a significant role in alleviating Machado-Joseph disease pathogenesis.

  7. Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.

    PubMed

    Raposo, Mafalda; Bettencourt, Conceição; Maciel, Patrícia; Gao, Fuying; Ramos, Amanda; Kazachkova, Nadiya; Vasconcelos, João; Kay, Teresa; Rodrigues, Ana João; Bettencourt, Bruno; Bruges-Armas, Jácome; Geschwind, Daniel; Coppola, Giovanni; Lima, Manuela

    2015-06-01

    Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3. Previous studies on cell and animal models have suggested that mutated ataxin-3 is involved in transcriptional dysregulation. Starting with a whole-transcriptome profiling of peripheral blood samples from patients and controls, we aimed to confirm abnormal expression profiles in Machado-Joseph disease and to identify promising up-regulated genes as potential candidate biomarkers of disease status. The Illumina Human V4-HT12 array was used to measure transcriptome-wide gene expression in peripheral blood samples from 12 patients and 12 controls. Technical validation and validation in an independent set of samples were performed by quantitative real-time polymerase chain reaction (PCR). Based on the results from the microarray, twenty six genes, found to be up-regulated in patients, were selected for technical validation by quantitative real-time PCR (validation rate of 81% for the up-regulation trend). Fourteen of these were further tested in an independent set of 42 patients and 35 controls; 10 genes maintained the up-regulation trend (FCGR3B, CSR2RA, CLC, TNFSF14, SLA, P2RY13, FPR2, SELPLG, YIPF6, and GPR96); FCGR3B, P2RY13, and SELPLG were significantly up-regulated in patients when compared with controls. Our findings support the hypothesis that mutated ataxin-3 is associated with transcription dysregulation, detectable in peripheral blood cells. Furthermore, this is the first report suggesting a pool of up-regulated genes in Machado-Joseph disease that may have the potential to be used for fine phenotyping of this disease. © 2015 International Parkinson and Movement Disorder Society. © 2015 International Parkinson and Movement Disorder Society.

  8. A 325-year reconstruction of St. Joseph River streamflow using tree rings

    NASA Astrophysics Data System (ADS)

    Schmidt, Karly R.

    The use of tree ring widths as indicators of water resource availability affords annual-scale resolution in the reconstruction of streamflow prior to the limited instrumental record. While an abundance of streamflow reconstructions have been conducted in the western United States, few have been undertaken in the eastern half of the country. This study aims to enhance understanding of regional hydroclimate in the Great Lakes region by presenting a 325-year streamflow reconstruction for the St. Joseph River, as well as contributing two new tree ring-width chronologies in Indiana and Michigan. A variety of factors potentially influencing the chance of successful streamflow reconstruction are also posited and discussed. A total of 55 tree ring width chronologies from Indiana, Illinois, Michigan, Wisconsin, and Ontario were examined using standard methods in dendrochronology and nested principal component analysis (PCA) to reconstruct St. Joseph River streamflow to 1675 with greater skill than climatology. The resulting overall reconstruction and periods identified as severe droughts and pluvials were in general agreement with other dendroclimatological studies in the eastern U.S. The findings suggest that the instrumental record (beginning in 1924) does not accurately depict long-term streamflow variability of the St. Joseph River. The reconstructed values tend to overestimate the intensity and duration of pluvial periods, but also show that droughts in the region were of similar intensity to those in the more recent past, but were of longer duration. This suggests that water resource managers may need to consider a wider range of variability than previously indicated by the instrumental record.

  9. NUCLEAR REACTOR CONTROL SYSTEM

    DOEpatents

    Epler, E.P.; Hanauer, S.H.; Oakes, L.C.

    1959-11-01

    A control system is described for a nuclear reactor using enriched uranium fuel of the type of the swimming pool and other heterogeneous nuclear reactors. Circuits are included for automatically removing and inserting the control rods during the course of normal operation. Appropriate safety circuits close down the nuclear reactor in the event of emergency.

  10. Improved vortex reactor system

    DOEpatents

    Diebold, James P.; Scahill, John W.

    1995-01-01

    An improved vortex reactor system for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor.

  11. Advanced Test Reactor Tour

    SciTech Connect

    Miley, Don

    2011-01-01

    The Advanced Test Reactor at Idaho National Laboratory is the foremost nuclear materials test reactor in the world. This virtual tour describes the reactor, how experiments are conducted, and how spent nuclear fuel is handled and stored. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  12. Advanced Test Reactor Tour

    ScienceCinema

    Miley, Don

    2016-07-12

    The Advanced Test Reactor at Idaho National Laboratory is the foremost nuclear materials test reactor in the world. This virtual tour describes the reactor, how experiments are conducted, and how spent nuclear fuel is handled and stored. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  13. NEUTRONIC REACTOR SHIELDING

    DOEpatents

    Borst, L.B.

    1961-07-11

    A special hydrogenous concrete shielding for reactors is described. In addition to Portland cement and water, the concrete essentially comprises 30 to 60% by weight barytes aggregate for enhanced attenuation of fast neutrons. The biological shields of AEC's Oak Ridge Graphite Reactor and Materials Testing Reactor are particular embodiments.

  14. High solids fermentation reactor

    DOEpatents

    Wyman, Charles E.; Grohmann, Karel; Himmel, Michael E.; Richard, Christopher J.

    1993-01-01

    A fermentation reactor and method for fermentation of materials having greater than about 10% solids. The reactor includes a rotatable shaft along the central axis, the shaft including rods extending outwardly to mix the materials. The reactor and method are useful for anaerobic digestion of municipal solid wastes to produce methane, for production of commodity chemicals from organic materials, and for microbial fermentation processes.

  15. High solids fermentation reactor

    DOEpatents

    Wyman, Charles E.; Grohmann, Karel; Himmel, Michael E.; Richard, Christopher J.

    1993-03-02

    A fermentation reactor and method for fermentation of materials having greater than about 10% solids. The reactor includes a rotatable shaft along the central axis, the shaft including rods extending outwardly to mix the materials. The reactor and method are useful for anaerobic digestion of municipal solid wastes to produce methane, for production of commodity chemicals from organic materials, and for microbial fermentation processes.

  16. Efficient Silicon Reactor

    NASA Technical Reports Server (NTRS)

    Bates, H. E.; Hill, D. M.; Jewett, D. N.

    1983-01-01

    High-purity silicon efficiently produced and transferred by continuous two-cycle reactor. New reactor operates in relatively-narrow temperature rate and uses large surfaces area to minimize heat expenditure and processing time in producing silicon by hydrogen reduction of trichlorosilane. Two cycles of reactor consists of silicon production and removal.

  17. The Forgotten Forefather: Joseph James Kinyoun and the Founding of the National Institutes of Health

    PubMed Central

    Morens, David M.; Fauci, Anthony S.

    2012-01-01

    ABSTRACT In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview examines Joseph James Kinyoun (1860 to 1919), the 1887 founder of a federal Hygienic Laboratory that is considered the direct ancestor of the modern NIH, and explores the development of NIH as it was shaped by, and in turn shaped, the new field of microbiology. PMID:22736540

  18. Machado-Joseph disease in New England: clinical description and distinction from the olivopontocerebellar atrophies.

    PubMed

    Sudarsky, L; Corwin, L; Dawson, D M

    1992-01-01

    Experience is described in 25 patients from southern New England with Machado-Joseph Disease, examined serially at annual screening clinics. The disorder is dominantly inherited, with a wide range of phenotypic variation. Core clinical features described include ataxia, nystagmus, dysarthria, facial fasciculations, and lid retraction, producing a characteristic staring expression. In addition, young onset patients have spasticity, extrapyramidal rigidity, and dystonic manifestations. Late onset patients often have distal atrophy and sensory loss. Postural instability is often an early feature. We discuss the distinction of this entity from the olivopontocerebellar atrophies.

  19. Excerpts from Joseph Stiglitz's speech to the World Bank, April 1999.

    PubMed

    Scher, A; Baxandall, P

    2000-01-01

    The Journal has published several articles critical of the World Bank and the International Monetary Fund. These articles have shown the damage caused by the neoliberal policies advocated by these agencies to the health and quality of life of the people in countries where such policies are carried out. Published here are excerpts of a speech given by Joseph Stiglitz, senior economist of the World Bank, in which he finally recognizes the damage these policies have caused in Russia, where life expectancy has fallen quite dramatically during the years of neoliberal reform. The question triggered by his speech is why the World Bank continues its neoliberal policies.

  20. Joseph Igersheimer (1879-1965): a visionary ophthalmologist and his contributions before and after exile.

    PubMed

    Namal, Arin; Reisman, Arnold

    2007-11-01

    While in forced exile from Nazi Germany between 1933 and 1939, Joseph Igersheimer was the architect of modern ophthalmology in Turkey. Earlier he was a pioneer in addressing the impact of syphilis on eyesight. He was the first to use arsphenamine in the treatment of syphilis of the eye and the first to operate on retinal detachment by closing the holes. In 1939 he joined Tufts University's Medical School and became a major contributor to America's ophthalmology. By the time of his retirement, over 2000 American ophthalmologists had listened to his lectures.

  1. Li-Fraumeni syndrome: Discovery and future challenges - Joseph Fraumeni Symposium

    Cancer.gov

    In May 2014, NCI’s Division of Cancer Epidemiology and Genetics (DCEG) hosted Cancer Epidemiology: From Pedigrees to Populations, a scientific symposium honoring 50 years of visionary leadership by Dr. Joseph F. Fraumeni, Jr., the founding Director of DCEG. In this video, Dr. Stephen Chanock of NCI provides opening remarks. Dr. David Schottenfeld of the University of Michigan moderates a session on the search for cancer susceptibility genes. Dr. Louise Strong of University of Texas MD Anderson Cancer Center speaks about the discovery and future challenges of Li-Fraumeni syndrome research. For more information on this symposium, visit http://dceg.cancer.gov/news-events/Fraumeni-symposium-speakers.

  2. Decoupling the Stationary Navier-Stokes-Darcy System with the Beavers-Joseph-Saffman Interface Condition

    DOE PAGES

    Cao, Yong; Chu, Yuchuan; He, Xiaoming; ...

    2013-01-01

    This paper proposes a domain decomposition method for the coupled stationary Navier-Stokes and Darcy equations with the Beavers-Joseph-Saffman interface condition in order to improve the efficiency of the finite element method. The physical interface conditions are directly utilized to construct the boundary conditions on the interface and then decouple the Navier-Stokes and Darcy equations. Newton iteration will be used to deal with the nonlinear systems. Numerical results are presented to illustrate the features of the proposed method.

  3. Johann Joseph Oppel (1855) on Geometrical–Optical Illusions: A Translation and Commentary

    PubMed Central

    Todorović, Dejan; Phillips, David; Lingelbach, Bernd

    2017-01-01

    The term geometrical–optical illusions was coined by Johann Joseph Oppel (1815–1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel’s article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them. PMID:28694957

  4. Joseph Lister (1827-1912): a pioneer of antiseptic surgery remembered a century after his death.

    PubMed

    Jessney, Benn

    2012-08-01

    Joseph Lister was a remarkable British surgeon who pioneered principles of antisepsis. He died 100 years ago after devoting his life to developing and promoting safe, antiseptic surgery. In the 1800 s as many as 80% of all operations resulted in infection but many people refused to accept the true nature of infection, believing instead that the deaths were coincidental. Lister became familiar with the work of Pasteur while working in Glasgow. He recognized the truth in Pasteur's work and in 1867 Lister published his landmark paper 'On the Antiseptic Principle in the Practice of Surgery' in the British Medical Journal. It proved to be a turning point in healthcare.

  5. Cascade ICF power reactor

    SciTech Connect

    Hogan, W.J.; Pitts, J.H.

    1986-05-20

    The double-cone-shaped Cascade reaction chamber rotates at 50 rpm to keep a blanket of ceramic granules in place against the wall as they slide from the poles to the exit slots at the equator. The 1 m-thick blanket consists of layers of carbon, beryllium oxide, and lithium aluminate granules about 1 mm in diameter. The x rays and debris are stopped in the carbon granules; the neutrons are multiplied and moderated in the BeO and breed tritium in the LiAlO/sub 2/. The chamber wall is made up of SiO tiles held in compression by a network of composite SiC/Al tendons. Cascade operates at a 5 Hz pulse rate with 300 MJ in each pulse. The temperature in the blanket reaches 1600 K on the inner surface and 1350 K at the outer edge. The granules are automatically thrown into three separate vacuum heat exchangers where they give up their energy to high pressure helium. The helium is used in a Brayton cycle to obtain a thermal-to-electric conversion efficiency of 55%. Studies have been done on neutron activation, debris recovery, vaporization and recondensation of blanket material, tritium control and recovery, fire safety, and cost. These studies indicate that Cascade appears to be a promising ICF reactor candidate from all standpoints. At the 1000 MWe size, electricity could be made for about the same cost as in a future fission reactor.

  6. Neutrino-4 experiment on the search for a sterile neutrino at the SM-3 reactor

    SciTech Connect

    Serebrov, A. P. Ivochkin, V. G.; Samoylov, R. M.; Fomin, A. K.; Zinoviev, V. G.; Neustroev, P. V.; Golovtsov, V. L.; Gruzinsky, N. V.; Solovey, V. A.; Chernyi, A. V.; Zherebtsov, O. M.; Martemyanov, V. P.; Tsinoev, V. G.; Tarasenkov, V. G.; Aleshin, V. I.; Petelin, A. L.; Pavlov, S. V.; Izhutov, A. L.; Sazontov, S. A.; Ryazanov, D. K.; and others

    2015-10-15

    In view of the possibility of the existence of a sterile neutrino, test measurements of the dependence of the reactor antineutrino flux on the distance from the reactor core has been performed on SM-2 reactor with the Neutrino-2 detector model in the range of 6–11 m. Prospects of the search for reactor antineutrinos at short distances have been discussed.

  7. Reactor vessel support system

    DOEpatents

    Golden, Martin P.; Holley, John C.

    1982-01-01

    A reactor vessel support system includes a support ring at the reactor top supported through a box ring on a ledge of the reactor containment. The box ring includes an annular space in the center of its cross-section to reduce heat flow and is keyed to the support ledge to transmit seismic forces from the reactor vessel to the containment structure. A coolant channel is provided at the outside circumference of the support ring to supply coolant gas through the keyways to channels between the reactor vessel and support ledge into the containment space.

  8. Nuclear reactor overflow line

    DOEpatents

    Severson, Wayne J.

    1976-01-01

    The overflow line for the reactor vessel of a liquid-metal-cooled nuclear reactor includes means for establishing and maintaining a continuous bleed flow of coolant amounting to 5 to 10% of the total coolant flow through the overflow line to prevent thermal shock to the overflow line when the reactor is restarted following a trip. Preferably a tube is disposed concentrically just inside the overflow line extending from a point just inside the reactor vessel to an overflow tank and a suction line is provided opening into the body of liquid metal in the reactor vessel and into the annulus between the overflow line and the inner tube.

  9. Thorium fueled reactor

    NASA Astrophysics Data System (ADS)

    Sipaun, S.

    2017-01-01

    Current development in thorium fueled reactors shows that they can be designed to operate in the fast or thermal spectrum. The thorium/uranium fuel cycle converts fertile thorium-232 into fissile uranium-233, which fissions and releases energy. This paper analyses the characteristics of thorium fueled reactors and discusses the thermal reactor option. It is found that thorium fuel can be utilized in molten salt reactors through many configurations and designs. A balanced assessment on the feasibility of adopting one reactor technology versus another could lead to optimized benefits of having thorium resource.

  10. Mechanical cutting of irradiated reactor internal components

    SciTech Connect

    Anderson, Michael G.

    2008-01-15

    Mechanical cutting methods to volume reduce and package reactor internal components are now a viable solution for stakeholders challenged with the retirement of first generation nuclear facilities. The recent completion of the removal of the Reactor Vessel Internals (RVI) from within the Sacramento Municipal Utility District's (SMUD) Rancho Seco Nuclear Power Plant demonstrates that unlike previous methods, inclusive of plasma arc and abrasive water-jet cutting, mechanical cutting minimizes exposure to workers, costly water cleanup, and excessive secondary waste generation. Reactor internal components were segmented, packaged, and removed from the reactor building for shipment or storage, allowing the reactor cavity to be drained and follow-on reactor segmentation activities to proceed in the dry state. Area exposure rates at the work positions during the segmentation process were generally 1 mR per hr. Radiological exposure documented for the underwater segmentation processes totaled 13 person rem. The reactor internals weighing 343,000 pounds were segmented into over 200 pieces for maximum shipping package efficiency and produced 5,600 lb of stainless steel chips and shavings which were packaged in void spaces of existing disposal containers, therefore creating no additional disposal volume. Because no secondary waste was driven into suspension in the reactor cavity water, the water was free released after one pass through a charcoal bed and ion exchange filter system. Mechanical cutting techniques are capable of underwater segmentation of highly radioactive components on a large scale. This method minimized radiological exposure and costly water cleanup while creating no secondary waste.

  11. High temperature reactors

    NASA Astrophysics Data System (ADS)

    Dulera, I. V.; Sinha, R. K.

    2008-12-01

    With the advent of high temperature reactors, nuclear energy, in addition to producing electricity, has shown enormous potential for the production of alternate transport energy carrier such as hydrogen. High efficiency hydrogen production processes need process heat at temperatures around 1173-1223 K. Bhabha Atomic Research Centre (BARC), is currently developing concepts of high temperature reactors capable of supplying process heat around 1273 K. These reactors would provide energy to facilitate combined production of hydrogen, electricity, and drinking water. Compact high temperature reactor is being developed as a technology demonstrator for associated technologies. Design has been also initiated for a 600 MWth innovative high temperature reactor. High temperature reactor development programme has opened new avenues for research in areas like advanced nuclear fuels, high temperature and corrosion resistant materials and protective coatings, heavy liquid metal coolant technologies, etc. The paper highlights design of these reactors and their material related requirements.

  12. Spinning fluids reactor

    DOEpatents

    Miller, Jan D; Hupka, Jan; Aranowski, Robert

    2012-11-20

    A spinning fluids reactor, includes a reactor body (24) having a circular cross-section and a fluid contactor screen (26) within the reactor body (24). The fluid contactor screen (26) having a plurality of apertures and a circular cross-section concentric with the reactor body (24) for a length thus forming an inner volume (28) bound by the fluid contactor screen (26) and an outer volume (30) bound by the reactor body (24) and the fluid contactor screen (26). A primary inlet (20) can be operatively connected to the reactor body (24) and can be configured to produce flow-through first spinning flow of a first fluid within the inner volume (28). A secondary inlet (22) can similarly be operatively connected to the reactor body (24) and can be configured to produce a second flow of a second fluid within the outer volume (30) which is optionally spinning.

  13. Reactor water cleanup system

    DOEpatents

    Gluntz, Douglas M.; Taft, William E.

    1994-01-01

    A reactor water cleanup system includes a reactor pressure vessel containing a reactor core submerged in reactor water. First and second parallel cleanup trains are provided for extracting portions of the reactor water from the pressure vessel, cleaning the extracted water, and returning the cleaned water to the pressure vessel. Each of the cleanup trains includes a heat exchanger for cooling the reactor water, and a cleaner for cleaning the cooled reactor water. A return line is disposed between the cleaner and the pressure vessel for channeling the cleaned water thereto in a first mode of operation. A portion of the cooled water is bypassed around the cleaner during a second mode of operation and returned through the pressure vessel for shutdown cooling.

  14. Reactor water cleanup system

    DOEpatents

    Gluntz, D.M.; Taft, W.E.

    1994-12-20

    A reactor water cleanup system includes a reactor pressure vessel containing a reactor core submerged in reactor water. First and second parallel cleanup trains are provided for extracting portions of the reactor water from the pressure vessel, cleaning the extracted water, and returning the cleaned water to the pressure vessel. Each of the cleanup trains includes a heat exchanger for cooling the reactor water, and a cleaner for cleaning the cooled reactor water. A return line is disposed between the cleaner and the pressure vessel for channeling the cleaned water thereto in a first mode of operation. A portion of the cooled water is bypassed around the cleaner during a second mode of operation and returned through the pressure vessel for shutdown cooling. 1 figure.

  15. Mutational origin of Machado-Joseph disease in the Australian Aboriginal communities of Groote Eylandt and Yirrkala.

    PubMed

    Martins, Sandra; Soong, Bing-Wen; Wong, Virginia C N; Giunti, Paola; Stevanin, Giovanni; Ranum, Laura P W; Sasaki, Hidenao; Riess, Olaf; Tsuji, Shoji; Coutinho, Paula; Amorim, António; Sequeiros, Jorge; Nicholson, Garth A

    2012-06-01

    To determine whether the presence of Machado-Joseph disease (MJD, also spinocerebellar ataxia type 3 [SCA3]) among Australian aborigines was caused by a new mutational event or by the introduction of expanded alleles from other populations. We sequenced a region of 4 kilobases (kb), encompassing the CAG repeat within the ATXN3 gene, in 2 affected Australian aboriginal families and compared them with the Joseph and Machado lineages described before. Full-extended haplotypes (including also more distant single-nucleotide polymorphisms and flanking short tandem repeats) were assessed by segregation and allele-specific amplification. A phylogenetic tree was inferred from genetic distances, and age of the Australasian Joseph-derived lineage was estimated. The aboriginal communities of Groote Eylandt and Yirrkala, in the Northern Territories, Australia (local ethics institutional permission was granted, and both community and individual informed consent was obtained). A convenience sample of 19 patients and unaffected relatives, from 2 Australian aboriginal families affected with MJD; 40 families with MJD of multiethnic origins and 50 unrelated Asian control subjects. The 2 aboriginal families shared the same full haplotype, including 20 single-nucleotide polymorphisms:TTGATCGAGC-(CAG)(Exp)-CACCCAGCGC, that is, the Joseph lineage with a G variant in rs56268847.Among 33 families with the Joseph lineage, this derived haplotype was found only in 5 of 16 Taiwanese, all 3 Indian,and 1 of 3 Japanese families analyzed. A related-extended MJD haplotype shared by Australian aborigines and some Asian families (a Joseph-derived lineage) suggests a common ancestor for all, dating back more than 7000 years.

  16. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

    PubMed

    Nóbrega, Clévio; Carmo-Silva, Sara; Albuquerque, David; Vasconcelos-Ferreira, Ana; Vijayakumar, Udaya-Geetha; Mendonça, Liliana; Hirai, Hirokazu; de Almeida, Luís Pereira

    2015-12-01

    Machado-Joseph disease is a progressive neurodegenerative disorder associated with the polyQ-expanded ataxin-3 (encoded by ATXN3), for which no therapy is available. With the aim of clarifying the mechanism of neurodegeneration, we hypothesized that the abnormally long polyQ tract would interact aberrantly with ataxin-2 (encoded by ATXN2), another polyQ protein whose function has recently been linked to translational regulation. Using patient's samples and cellular and animal's models we found that in Machado-Joseph disease: (i) ataxin-2 levels are reduced; and (ii) its subcellular localization is changed towards the nucleus. Restoring ataxin-2 levels by lentiviral-mediated overexpression: (i) reduced mutant ataxin-3 levels; and (ii) rescued behaviour defects and neuropathology in a transgenic mouse model of Machado-Joseph disease. Conversely (i) mutating the ataxin-2 motif that enables binding to its natural interactor and translation activator poly(A)-binding protein; or (ii) overexpressing poly(A)-binding protein, had opposite effects, increasing mutant ataxin-3 translation and aggregation. This work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease. Re-establishment of ataxin-2 levels reduces mutant ataxin-3 and alleviates Machado-Joseph disease pathogenesis opening a new avenue for therapeutic intervention in this and potentially other polyQ disorders. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.

    PubMed

    Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís

    2013-07-01

    Machado-Joseph disease or spinocerebellar ataxia type 3, the most common dominantly-inherited spinocerebellar ataxia, results from translation of the polyglutamine-expanded and aggregation prone ataxin 3 protein. Clinical manifestations include cerebellar ataxia and pyramidal signs and there is no therapy to delay disease progression. Beclin 1, an autophagy-related protein and essential gene for cell survival, is decreased in several neurodegenerative disorders. This study aimed at evaluating if lentiviral-mediated beclin 1 overexpression would rescue motor and neuropathological impairments when administered to pre- and post-symptomatic lentiviral-based and transgenic mouse models of Machado-Joseph disease. Beclin 1-mediated significant improvements in motor coordination, balance and gait with beclin 1-treated mice equilibrating longer periods in the Rotarod and presenting longer and narrower footprints. Furthermore, in agreement with the improvements observed in motor function beclin 1 overexpression prevented neuronal dysfunction and neurodegeneration, decreasing formation of polyglutamine-expanded aggregates, preserving Purkinje cell arborization and immunoreactivity for neuronal markers. These data show that overexpression of beclin 1 in the mouse cerebellum is able to rescue and hinder the progression of motor deficits when administered to pre- and post-symptomatic stages of the disease.

  18. Iterative CT reconstruction with small pixel size: distance-driven forward projector versus Joseph's

    NASA Astrophysics Data System (ADS)

    Hahn, K.; Rassner, U.; Davidson, H. C.; Schöndube, H.; Stierstorfer, K.; Hornegger, J.; Noo, F.

    2015-03-01

    Over the last few years, iterative reconstruction methods have become an important research topic in x-ray CT imaging. This effort is motivated by increasing evidence that such methods may enable significant savings in terms of dose imparted to the patient. Conceptually, iterative reconstruction methods involve two important ingredients: the statistical model, which includes the forward projector, and a priori information in the image domain, which is expressed using a regularizer. Most often, the image pixel size is chosen to be equal (or close) to the detector pixel size (at field-of-view center). However, there are applications for which a smaller pixel size is desired. In this investigation, we focus on reconstruction with a pixel size that is twice smaller than the detector pixel size. Using such a small pixel size implies a large increase in computational effort when using the distance-driven method for forward projection, which models the detector size. On the other hand, the more efficient method of Joseph will create imbalances in the reconstruction of each pixel, in the sense that there will be large differences in the way each projection contributes to the pixels. The purpose of this work is to evaluate the impact of these imbalances on image quality in comparison with utilization of the distance-driven method. The evaluation involves computational effort, bias and noise metrics, and LROC analysis using human observers. The results show that Joseph's method largely remains attractive.

  19. [A missing name in the history of chagasic megaesophagus: Joseph Cooper Reinhardt (1809/10-1873)].

    PubMed

    Meneghelli, U G; de Rezende, J M; Troncon, L E; Madrid, N; de Moura, M L

    1998-01-01

    The book entitled "Brazil and the Brasilians", written by the Reverends Kidder and Fletcher and firstly published in the United States in 1857, reports the travels of these two missionaries throughout Brazil and includes a section entitled "A new disease". This section contains data regarding the clinical picture, the natural history and the epidemiology of a commom disease in Brazilian hinterland, which was known as "mal de engasgo". These informations were collected in 1855 by Rev. Fletcher from an anonymous North American physician, who worked in Limeira, State of São Paulo, and is called in the book merely as "Dr.-". The present work reports the results of an investigation carried out aiming at the identification of "Dr.-" and discloses documental evidence that "Dr.-" was actually Dr. Joseph Cooper Reinhardt (1809/10-1883). Dr. Reinhardt worked for many years in the citites of Limeira and Campinas, State of São Paulo, and probably had an extensive knowledge regarding the main features of this particular disease, which would be known, nearly 100 years later, as chagasic megaesophagus. The authors point out that, from now on, any account of the history of chagasic megaesophagus must include the name of Dr. Joseph Cooper Reinhardt.

  20. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection.

    PubMed

    Koob, George F

    2017-04-01

    W. Horsley Gantt and Joseph V. Brady laid a rich foundation for understanding the concept of emotion, derived from 2 prominent traditions of physiology and psychology: classic conditioning and operant conditioning, respectively. This framework guided my fierce interest in motivation in general and the interaction between reward and stress, which began at John Hopkins with my thesis work under the guidance of Drs. Zoltan Annau, Solomon Synder, and Joseph Brady, among many others. Using the study of the neurobiology of addiction as a framework, I argue that drug addiction not only involves positive reinforcement associated with the rewarding effects of drugs of abuse but also involves another major source of reinforcement, specifically negative reinforcement driven by negative emotional states (termed the "dark side" of addiction). Excessive activation of the brain reward systems leads to antireward or a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of the brain stress systems, both of which may be neurobiologically linked. Understanding the neuroplasticity of the neurocircuitry that comprises the negative reinforcement associated with addiction is a key to understanding negative emotional states in general and their pathophysiology.

  1. Agricultural land use and water quality in the upper St. Joseph River basin, Michigan

    USGS Publications Warehouse

    Cummings, T. Ray

    1978-01-01

    Land use in the upper St. Joseph River basin of south-central Michigan is primarily agricultural. In the 144-square-mile area, the chemical and physical characteristics of water are determined by the climate and soils, as well as by land conservation practices. Municipal waste discharges affect water quality at some locations, as do the larger lakes and ponds. Data indicate that mean discharge from the basin is 135 cubic feet per second. About half this flow is contributed to the St. Joseph River by three major tributaries: Beebe Creek (36 cubic feet per second); Sand Creek (24 cubic feet per second); and Soap Creek (13 cubic feet per second). Runoff from 21 drainage areas delineated for the investigation ranged from 0.22 to 4.07 cubic feet per second per square mile; both the higher and lower values are largely the result of naturally occurring inter- and intrabasin transfers of water.Suspended-sediment concentrations are low throughout the basin, rarely exceeding 100 milligrams per liter. Mean concentrations at four daily sampling stations on the major tributaries and on the St. Joseph River ranged from 9.7 milligrams per liter to 38 milligrams per liter. The maximum sediment yield was 182 pounds per acre per year. Deposition of sediment in five of the 21 areas resulted in a net loss of sediment transported, and thus “negative” yields.Nitrogen and phosphorus concentrations do not vary greatly from site to site. Mean concentrations of total nitrogen at downstream sites on Beebe, Sand, and Soap Creeks, and on the St. Joseph River ranged from 1.5 to 1.8 milligrams per liter. About 90 percent of all nitrogen, and 66 percent of all phosphorus, is transported in solution. Land used principally for agriculture has a mean total nitrogen yield of 4.9 pounds per acre per year and a mean total phosphorus yield of 0.13 pounds per year. A comparison of total nitrogen and total phosphorus yields with type of agricultural use showed few relationships; nitrogen yield

  2. Sustainable Planning Practices in St. Joseph Watershed as a Mixed Land-Use Watershed to Reduce the Risk of Chemical Impairment of Surface Water Supplies

    USDA-ARS?s Scientific Manuscript database

    Increased population growth in St. Joseph Watershed and the mix of land-use with urban and agricultural production brings about chemical impairment of metropolitan drinking water supplies. Furthermore, the St. Joseph Watershed is not only a drinking water supply, but also it provides water for recre...

  3. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334... Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. (a... the Commanding Officer, Tyndall Air Force Base, Florida, and such agencies as he may designate.......

  4. 75 FR 50010 - Atchison Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc.), CityFed Financial Corp., Divine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... COMMISSION Atchison Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc.), CityFed Financial Corp., Divine, Inc. (n/k/a Enivid, Inc.), Genesis Worldwide, Inc., Hampton Consulting Corp., and Jake's Pizza... Casting Corp. (n/k/a Bradken-Atchison/St. Joseph, Inc.) because it has not filed any periodic...

  5. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2002-2003 Annual Report.

    SciTech Connect

    Johnson, R.; McKinstry, C.; Simmons, C.

    2003-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the second year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The 2002 study period extended from May 18 through July 30. The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. The prototype system consisted of six strobe lights affixed to an aluminum frame suspended vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, were aimed to illuminate a specific region directly upstream of the barge. Three light level treatments were used: 6 of 6 lights on, 3 of 6 lights on, and all lights off. These three treatment conditions were applied for an entire 24-hr day and were randomly assigned within a 3-day block throughout the study period. A seven-transducer splitbeam

  6. ETF reactor design status

    SciTech Connect

    Sager, P.H.

    1981-04-01

    Conceptual design studies of a tokamak Engineering Test Facility (ETF) are being carried out as a joint laboratory--industry effort at the ETF Design Center at Oak Ridge National Laboratory (ORNL). Designs are being developed for two reactors, one with a bundle divertor and one with a poloidal divertor. These machines, which are designed for ignition and a burn time of 100 s, both have a major radius of 5.4 m, a plasma minor radius of 1.3 m, and a D-shaped plasma elongation ratio of 1.6. The plasma chamber must be conditioned at 10/sup -7/ Torr (10/sup -5/ Pa). During the 13 s dwell between burns, the chamber must be pumped down from 3 x 10/sup -4/ to 3 x 10/sup -5/ Torr. In the design with the bundle divertor, four pairs of compound cryopumps, each pump with a 4 m/sup 2/ cryosorption pumping surface, are installed to pump down the plasma chamber. In the design with the poloidal divertor, the plasma chamber is evacuated with the ten pairs of compound cryopumps, each pump with a cryosorption pumping surface of 13 m/sup 2/, installed to handle the divertor load. In both cases the pumps are installed in pairs so that one set can be regenerated while the other set is on-line.

  7. ETF reactor design status

    SciTech Connect

    Sager, P.H.

    1980-01-01

    Conceptual design studies of a tokamak Engineering Test Facility (ETF) are being carried out as a joint laboratory-industry effort at the ETF Design Center at Oak Ridge National Laboratory (ORNL). Designs are being developed for two reactors, one with a bundle divertor and one with a poloidal divertor. These machines, which are designed for ignition and a burn time of 100 s, both have a major radius of 5.4 m, a plasma minor radius of 1.3 m, and a D-shaped plasma elongation of 1.6. The plasma chamber must be conditioned at 10/sup -7/ torr. During the 35-s dwell between burns, the chamber must be pumped down from 5 x 10/sup -3/ torr to 3 x 10/sup -5/ torr. In the design with the bundle divertor four pairs of compound cryopumps, each pump with a 2-m/sup 2/ cryosorption pumping surface, are installed to pump down the plasma chamber. In the design with the poloidal divertor the plasma chamber is evacuated with the ten pairs of compound cryopumps, each pump with a cryosorption pumping surface of 4.32 m/sup 2/, installed to handle the divertor load. In both cases the pumps are installed in pairs so that one set can be regenerated while the other set is on-line.

  8. Neutron fluxes in test reactors

    SciTech Connect

    Youinou, Gilles Jean-Michel

    2017-01-01

    Communicate the fact that high-power water-cooled test reactors such as the Advanced Test Reactor (ATR), the High Flux Isotope Reactor (HFIR) or the Jules Horowitz Reactor (JHR) cannot provide fast flux levels as high as sodium-cooled fast test reactors. The memo first presents some basics physics considerations about neutron fluxes in test reactors and then uses ATR, HFIR and JHR as an illustration of the performance of modern high-power water-cooled test reactors.

  9. Hot Gas Desulfurization Using Transport Reactors

    SciTech Connect

    Moorehead, E.L.

    1996-12-31

    Sierra Pacific Power Company is building a 100 MW, IGCC power plant based on KRW fluid bed gasifier technology that utilizes transport reactors for hot gas desulfurization and sorbent regeneration. Use of a transport absorber avoids the need for pre-filtration of dust-laden gasifier effluent, while a transport regenerator allows for the use of 100% air without the need for heat exchange equipment. Selection of transport reactors for hot gas desulfurization using a proprietary sorbent, based on testing performed in a transport reactor test unit (TRTU) at the M. W. Kellogg Technology Development Center and in a fixed bed reactor at Morgantown Energy Technology Center (METC), is outlined. The results obtained in these two test facilities and reasons for selecting transport reactors for the IGCC power plant in preference to either fixed bed or fluidized bed reactors are discussed. This paper reviews the evolution of the hot gas desulfurization system designs and includes selected results on H{sub 2}S absorption and regeneration of sulfided sorbent over several absorption/regeneration cycles conducted in the TRTU and the METC fixed bed reactor. The original design for the Sierra Pacific Project was based on fixed bed reactors with zinc ferrite as the sorbent. Owing to the high steam requirements of this sorbent, zinc titanate was selected and tested in a fixed bed reactor and was found unacceptable due to loss of strength on cyclic absorption/regeneration operation. Another sorbent evaluated was Z-Sorb{reg_sign}, a proprietary sorbent developed by Phillips Petroleum Company, was found to have excellent sulfur capacity, structural strength and regenerability. Steam was found unsuitable as fixed bed regenerator diluent, this results in a requirement for a large amount of inert gas, whereas a transport regenerator requires no diluent. The final Sierra design features transport reactors for both desulfurization and regeneration steps using neat air. 3 refs., 3 figs., 2 tabs.

  10. Using 3D acoustic telemetry to assess the response of resident salmonids to strobe lights in Lake Roosevelt, Washington: Chief Joseph Kokanee Enhancement Feasibility Study, 2001-2002 annual report

    USGS Publications Warehouse

    Perry, R.W.; Farley, M.J.; Hansen, G.S.; Shurtleff, D.J.; Rondorf, D.W.; LeCaire, R.

    2003-01-01

    In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse.

  11. HORIZONTAL BOILING REACTOR SYSTEM

    DOEpatents

    Treshow, M.

    1958-11-18

    Reactors of the boiling water type are described wherein water serves both as the moderator and coolant. The reactor system consists essentially of a horizontal pressure vessel divided into two compartments by a weir, a thermal neutronic reactor core having vertical coolant passages and designed to use water as a moderator-coolant posltioned in one compartment, means for removing live steam from the other compartment and means for conveying feed-water and water from the steam compartment to the reactor compartment. The system further includes auxiliary apparatus to utilize the steam for driving a turbine and returning the condensate to the feed-water inlet of the reactor. The entire system is designed so that the reactor is self-regulating and has self-limiting power and self-limiting pressure features.

  12. High energy reactor neutrinos

    NASA Astrophysics Data System (ADS)

    Raper, Neill

    We present the first measurement of a nonzero reactor neutrino flux with energies above 8 MeV. Measurements are taken with the Daya Bay Reactor Neutrino Experiments detectors, using the Guangdong Nuclear Power Station as a source. Disagreement between data and theory regarding rate and shape of reactor neutrino spectra have made the need for direct measurement clear. Data are especially useful at high energies, where far fewer isotopes contribute. Neutrino candidates are correlated to reactor power and reactor power is extrapolated to zero in order to separate neutrino events from background. We find evidence of reactor neutrinos up to ˜12.5 MeV at 1.92 sigma above 0 and include a survey of isotopes likely to be contributing neutrinos in this energy range.

  13. Flood-inundation maps for the St. Joseph River at Elkhart, Indiana

    USGS Publications Warehouse

    Martin, Zachary W.

    2017-02-01

    Digital flood-inundation maps for a 6.6-mile reach of the St. Joseph River at Elkhart, Indiana, were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at https://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind. Real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at https://waterdata.usgs.gov/nwis or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS site EKMI3).Flood profiles were computed for the stream reach by means of a one-dimensional, step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current stage-discharge rating at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind., and the documented high-water marks from the flood of March 1982. The hydraulic model was then used to compute six water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 23.0 ft (the NWS “action stage”) to 28.0 ft, which is the highest stage interval of the current USGS stage-discharge rating curve and 1 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar] data having a 0.49-ft root mean squared error and 4.9-ft horizontal resolution, resampled to a 10-ft grid) to delineate the area flooded at each stage.The availability of these maps, along with Internet information

  14. Improved vortex reactor system

    DOEpatents

    Diebold, J.P.; Scahill, J.W.

    1995-05-09

    An improved vortex reactor system is described for affecting fast pyrolysis of biomass and Refuse Derived Fuel (RDF) feed materials comprising: a vortex reactor having its axis vertically disposed in relation to a jet of a horizontally disposed steam ejector that impels feed materials from a feeder and solids from a recycle loop along with a motive gas into a top part of said reactor. 12 figs.

  15. The Integral Fast Reactor

    SciTech Connect

    Chang, Y.I.

    1988-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics. 3 refs., 4 figs., 1 tab.

  16. NEUTRONIC REACTOR CONTROL

    DOEpatents

    Dreffin, R.S.

    1959-12-15

    A control means for a nuclear reactor is described. Particularly a device extending into the active portion of the reactor consisting of two hollow elements coaxially disposed and forming a channel therebetween, the cross sectional area of the channel increasing from each extremity of the device towards the center thereof. An element of neutron absorbing material is slidably positionable within the inner hollow element and a fluid reactor poison is introduced into the channel defined by the two hollow elements.

  17. NEUTRONIC REACTOR SYSTEM

    DOEpatents

    Goett, J.J.

    1961-01-24

    A system is described which includes a neutronic reactor containing a dispersion of fissionable material in a liquid moderator as fuel and a conveyor to which a portion of the dispersion may be passed and wherein the self heat of the slurry evaporates the moderator. Means are provided for condensing the liquid moderator and returning it to the reactor and for conveying the dried fissionable material away from the reactor.

  18. FLOW SYSTEM FOR REACTOR

    DOEpatents

    Zinn, W.H.

    1963-06-11

    A reactor is designed with means for terminating the reaction when returning coolant is below a predetermined temperature. Coolant flowing from the reactor passes through a heat exchanger to a lower reservoir, and then circulates between the lower reservoir and an upper reservoir before being returned to the reactor. Means responsive to the temperature of the coolant in the return conduit terminate the chain reaction when the temperature reaches a predetermined minimum value. (AEC)

  19. University Reactor Sharing Program

    SciTech Connect

    Dr. W.D. Reece

    1999-09-01

    The University Reactor Sharing Program provides funding for reactor experimentation to institutions that do not normally have access to a research reactor. Research projects supported by the program include items such as dating geological material to producing high current super conducting magnets. The funding also gives small colleges and universities the opportunity to use the facility for teaching courses in nuclear processes; specifically neutron activation analysis and gamma spectroscopy.

  20. A Special Needs Post-High School Program at St. Joseph College: "If They Could See Me Now..."

    ERIC Educational Resources Information Center

    Nardone, Alex; McGrath, Glenn

    This collection of materials describes a collaborative program between the West Hartford (Connecticut) Public Schools and St. Joseph College (Connecticut) to prepare special needs students who have completed high school for transition to employment and community living. The program is intended to provide meaningful integration of special needs…

  1. RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.

    PubMed

    Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Déglon, Nicole; de Almeida, Luís Pereira

    2014-01-01

    Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene silencing at an early time-point is able to prevent the appearance of motor behavior deficits typical of the disease when initiated before onset of the disease had not been explored. Here, using a lentiviral-mediated allele-specific silencing of mutant ataxin-3 in an early pre-symptomatic cerebellar mouse model of Machado-Joseph disease we show that this strategy hampers the development of the motor and neuropathological phenotypic characteristics of the disease. At the histological level, the RNA-specific silencing of mutant ataxin-3 decreased formation of mutant ataxin-3 aggregates, preserved Purkinje cell morphology and expression of neuronal markers while reducing cell death. Importantly, gene silencing prevented the development of impairments in balance, motor coordination, gait and hyperactivity observed in control mice. These data support the therapeutic potential of RNA interference for Machado-Joseph disease and constitute a proof of principle of the beneficial effects of early allele-specific silencing for therapy of this disease.

  2. Effects of Agricultural and Conservation Practices on Nutrients Losses from the St. Joseph River Watershed, Northeast Indiana

    USDA-ARS?s Scientific Manuscript database

    Agriculture has been identified as a primary contributor to nutrients that cause algal blooms in the Gulf of Mexico and Lake Erie. Since 2002, we have been monitoring water quality from agricultural drainage ditches in the St. Joseph River watershed to assess the impacts of agricultural and conserva...

  3. The Integration of Listening Skills as a Complement to Speaking Skills in the St. Joseph's College Core I Program.

    ERIC Educational Resources Information Center

    Cappuccilli, Ralph M.

    James Kinneavy's "Theory of Discourse," already being used as the model for the writing assignments in the curriculum at St. Joseph's College, can also be used as the model for listening and speaking assignments. This proposed project would incorporate the following four-step procedure: (1) determining what is necessary in preparing…

  4. Howard Joseph McKee, Jr., Winnebago Traditionalist. With Teacher's Guide. Native Americans of the Twentieth Century.

    ERIC Educational Resources Information Center

    Minneapolis Public Schools, MN.

    A biography for elementary school students describes Howard Joseph McKee, Jr, an American Indian elder who teaches the Winnebago language and is developing a system for translating it into English. Mr. McKee's photograph and a map of Nebraska reservations are included. A teaching guide following the bibliography contains learning objectives and…

  5. Use of surface and borehole geophysics to delineate the glacial-drift stratigraphy of northeastern St. Joseph County, Indiana

    USGS Publications Warehouse

    Bayless, E. Randall; Westjohn, David B.; Watson, Lee R.

    1995-01-01

    Inverse models of direct current electrical- resistivity sounding data and normal-resistivity and natural-gamma logs were used to assist delineation of the glacial-drift stratigraphy in a 580-square- kilometer area of northeastern St. Joseph County, Indiana. Unconsolidated deposits in the study area are composed of glacial-drift, including outwash, till, and lacustrine sediments; thicknesses range from about 15 to more than 70 meters. The glacial outwash deposits are mostly composed of sand and gravel and are the primary source of drinking water to northeastern St. Joseph County. The glacial till and glacio-lacustrine deposits contain a larger fraction of clay than the outwash deposits and may retard ground-water flow between shallow and deeper sand and gravel aquifers. Results of the geophysical measurements collected during this study indicate that glacial-drift deposits in the area north and east of the St. Joseph River are mostly composed of sand and gravel with inter-layered clay-rich deposits that are laterally discontinuous. In the area south of the St. Joseph River, the thickness of sand and gravel deposits diminishes, and clay-rich deposits dominate the stratigraphy. The presence of an electrically conductive bedrock, the Ellsworth Shale, beneath the glacial-drift deposits is identified in inverse models of direct current electrical-resistivity sounding data.

  6. [Joseph Crofts, et al., Plaintiffs, vs. Board of Governors of California Community Colleges, et al., Defendants. Consent Decree.

    ERIC Educational Resources Information Center

    District Court, San Francisco, CA. Northern District of California.

    A consent decree between Joseph Crofts, et al., and the Board of Governors of California Community Colleges terminating litigation regarding alleged patterns and practices of discrimination in employment and education against persons of Spanish heritage at Contra Costa College is presented. The decree outlines provisions to be followed under the…

  7. RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease

    PubMed Central

    Onofre, Isabel; Albuquerque, David; Déglon, Nicole; Pereira de Almeida, Luís

    2014-01-01

    Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene silencing at an early time-point is able to prevent the appearance of motor behavior deficits typical of the disease when initiated before onset of the disease had not been explored. Here, using a lentiviral-mediated allele-specific silencing of mutant ataxin-3 in an early pre-symptomatic cerebellar mouse model of Machado-Joseph disease we show that this strategy hampers the development of the motor and neuropathological phenotypic characteristics of the disease. At the histological level, the RNA-specific silencing of mutant ataxin-3 decreased formation of mutant ataxin-3 aggregates, preserved Purkinje cell morphology and expression of neuronal markers while reducing cell death. Importantly, gene silencing prevented the development of impairments in balance, motor coordination, gait and hyperactivity observed in control mice. These data support the therapeutic potential of RNA interference for Machado-Joseph disease and constitute a proof of principle of the beneficial effects of early allele-specific silencing for therapy of this disease. PMID:25144231

  8. Research Administration in History: The Development of OMB Circular A-110 through Joseph Warner's COGR Subcommittee, 1976-1979

    ERIC Educational Resources Information Center

    Myers, Phillip E.; Smith, Marie F.

    2008-01-01

    Research administrators can be assisted in resolving issues with awareness of the critical period of policy formation divulged in the Joseph Warner Papers. He and his colleagues on the Subcommittee on Grants and Contracts Provisions of COGR adopted the philosophy that research administrators needed flexibility and reduced paperwork and costs.…

  9. Defining American Heroes: Analyzing the Metamorphosis of the War Hero in Twentieth Century War Films Using Joseph Campbell's, "Hero's Journey."

    ERIC Educational Resources Information Center

    Frith, Luci A.

    In "The Hero's Journey" Joseph Campbell identifies the patterns that inform the myths of the "hero" throughout recorded history. By using Campbell's template, this paper examines how the American war hero is portrayed and has been portrayed in film. The paper states that Americans not only define their war heroes in films but…

  10. Howard Joseph McKee, Jr., Winnebago Traditionalist. With Teacher's Guide. Native Americans of the Twentieth Century.

    ERIC Educational Resources Information Center

    Minneapolis Public Schools, MN.

    A biography for elementary school students describes Howard Joseph McKee, Jr, an American Indian elder who teaches the Winnebago language and is developing a system for translating it into English. Mr. McKee's photograph and a map of Nebraska reservations are included. A teaching guide following the bibliography contains learning objectives and…

  11. Pressurized fluidized bed reactor

    DOEpatents

    Isaksson, Juhani

    1996-01-01

    A pressurized fluid bed reactor power plant includes a fluidized bed reactor contained within a pressure vessel with a pressurized gas volume between the reactor and the vessel. A first conduit supplies primary gas from the gas volume to the reactor, passing outside the pressure vessel and then returning through the pressure vessel to the reactor, and pressurized gas is supplied from a compressor through a second conduit to the gas volume. A third conduit, comprising a hot gas discharge, carries gases from the reactor, through a filter, and ultimately to a turbine. During normal operation of the plant, pressurized gas is withdrawn from the gas volume through the first conduit and introduced into the reactor at a substantially continuously controlled rate as the primary gas to the reactor. In response to an operational disturbance of the plant, the flow of gas in the first, second, and third conduits is terminated, and thereafter the pressure in the gas volume and in the reactor is substantially simultaneously reduced by opening pressure relief valves in the first and third conduits, and optionally by passing air directly from the second conduit to the turbine.

  12. Remote Reactor Monitoring

    SciTech Connect

    Bernstein, Adam; Dazeley, Steve; Dobie, Doug; Marleau, Peter; Brennan, Jim; Gerling, Mark; Sumner, Matthew; Sweany, Melinda

    2014-10-21

    The overall goal of the WATCHMAN project is to experimentally demonstrate the potential of water Cerenkov antineutrino detectors as a tool for remote monitoring of nuclear reactors. In particular, the project seeks to field a large prototype gadolinium-doped, water-based antineutrino detector to demonstrate sensitivity to a power reactor at ~10 kilometer standoff using a kiloton scale detector. The technology under development, when fully realized at large scale, could provide remote near-real-time information about reactor existence and operational status for small operating nuclear reactors out to distances of many hundreds of kilometers.

  13. Pressurized fluidized bed reactor

    DOEpatents

    Isaksson, J.

    1996-03-19

    A pressurized fluid bed reactor power plant includes a fluidized bed reactor contained within a pressure vessel with a pressurized gas volume between the reactor and the vessel. A first conduit supplies primary gas from the gas volume to the reactor, passing outside the pressure vessel and then returning through the pressure vessel to the reactor, and pressurized gas is supplied from a compressor through a second conduit to the gas volume. A third conduit, comprising a hot gas discharge, carries gases from the reactor, through a filter, and ultimately to a turbine. During normal operation of the plant, pressurized gas is withdrawn from the gas volume through the first conduit and introduced into the reactor at a substantially continuously controlled rate as the primary gas to the reactor. In response to an operational disturbance of the plant, the flow of gas in the first, second, and third conduits is terminated, and thereafter the pressure in the gas volume and in the reactor is substantially simultaneously reduced by opening pressure relief valves in the first and third conduits, and optionally by passing air directly from the second conduit to the turbine. 1 fig.

  14. HOMOGENEOUS NUCLEAR POWER REACTOR

    DOEpatents

    King, L.D.P.

    1959-09-01

    A homogeneous nuclear power reactor utilizing forced circulation of the liquid fuel is described. The reactor does not require fuel handling outside of the reactor vessel during any normal operation including complete shutdown to room temperature, the reactor being selfregulating under extreme operating conditions and controlled by the thermal expansion of the liquid fuel. The liquid fuel utilized is a uranium, phosphoric acid, and water solution which requires no gus exhaust system or independent gas recombining system, thereby eliminating the handling of radioiytic gas.

  15. Membrane reactors at Degussa.

    PubMed

    Wöltinger, Jens; Karau, Andreas; Leuchtenberger, Wolfgang; Drauz, Karlheinz

    2005-01-01

    The review covers the development of membrane reactor technologies at Degussa for the synthesis of fine chemicals. The operation of fed-batch or continuous biocatalytic processes in the enzyme membrane reactor (EMR) is well established at Degussa. Degussa has experience of running EMRs from laboratory gram scale up to a production scale of several hundreds of tons per year. The transfer of the enzyme membrane reactor from biocatalysis to chemical catalysis in the chemzyme membrane reactor (CMR) is discussed. Various homogeneous catalysts have been investigated in the CMR, and the scope and limitation of this new technique is discussed.

  16. 75 FR 28074 - Advisory Committee on Reactor Safeguards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... COMMISSION Advisory Committee on Reactor Safeguards In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS... Accidental Radionuclide Releases.'' 10:15 a.m.-12 p.m.: Status of Risk-Informing Guidance of New...

  17. 75 FR 21046 - Advisory Committee on Reactor Safeguards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... COMMISSION Advisory Committee on Reactor Safeguards In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS... discussions with the NRC Chairman to discuss topics of mutual interest. 1 p.m.-4 p.m.: Boiling Water...

  18. St. Joseph River at Elkhart, Indiana, flood-inundation HEC-RAS Model

    USGS Publications Warehouse

    Martin, Zachary W.

    2017-01-01

    Digital flood-inundation maps for a 6.6-mile reach of the St. Joseph River at Elkhart, Indiana were created by the U.S. Geological Survey (USGS) in cooperation with the Indiana Office of Community and Rural Affairs. The flood-inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind. Near-real-time stages at this streamgage may be obtained on the Internet from the USGS National Water Information System at http://waterdata.usgs.gov/ or the National Weather Service (NWS) Advanced Hydrologic Prediction Service at http:/water.weather.gov/ahps/, which also forecasts flood hydrographs at this site (NWS site EKMI3). Flood profiles were computed for the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind., reach by means of a one-dimensional step-backwater hydraulic modeling software developed by the U.S. Army Corps of Engineers. The hydraulic model was calibrated using the current stage-discharge rating at the USGS streamgage 04101000, St. Joseph River at Elkhart, Ind. The hydraulic model was then used to compute 6 water-surface profiles for flood stages at 1-foot (ft) intervals referenced to the streamgage datum ranging from 23.0 ft (the NWS “action stage”) to 28.0 ft, which is the highest stage interval of the current USGS stage-discharge rating curve and 1 ft higher than the NWS “major flood stage.” The simulated water-surface profiles were then combined with a Geographic Information System digital elevation model (derived from light detection and ranging [lidar]) data having a 0.49-ft root mean squared error and 4.9-ft horizontal resolution) to delineate the area flooded at each stage. The availability of these maps, along with Internet information regarding current stage from the USGS streamgage

  19. On the origins of organology: Franz Joseph Gall and a girl named Bianchi.

    PubMed

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2017-01-01

    Franz Joseph Gall (1758-1828) introduced a new theory of mind and brain at the end of the eighteenth century, which he referred to as organology, dealing with mental functions and their cortical localizations. Gall wrote that observations regarding the verbal learning capacities of his schoolmates brought about his new way of thinking. This widely accepted view, however, requires qualification. Although Gall's experiences and observations as a schoolboy were relevant, especially for his craniology, these childhood memories might have been recalled and reinterpreted after he had started to think about the faculties of mind-specifically after he had met Bianchi, a 5-year-old girl with a special talent for music.

  20. A kind of Mozart of medicine: Joseph Plenck (1735-1807).

    PubMed

    Holubar, Karl

    2003-12-01

    This is a tribute to one of the fathers of modern European dermatology and venereology, Dr Joseph Plenck, the Viennese protodermatologist of two hundred years ago, 1735-1807, who was professor and secretary of the Imperial Medical Josephine Academy, where today is the Institute for the history of medicine. Plenck introduced the systematization of dermatovenereological diseases based on their paradigmatic differences, which is deemed as "the only (system) with pretensions to accuracy". A man of diversified interests and a fruitful author, he wrote many treatises covering various fields from dermatology, venereology, and dentistry to surgery, obstetrics, anatomy, pediatrics, pharmacology, and botany. This remarkable physician definitely left a deep trace in the history of dermatology and venereology, and marked the transition from text-based to visually dependent culture in the field of dermatovenereology.