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Sample records for juan del ro

  1. Paleogene and Neogene magmatism in the Valle del Cura region: New perspective on the evolution of the Pampean flat slab, San Juan province, Argentina

    NASA Astrophysics Data System (ADS)

    Litvak, Vanesa D.; Poma, Stella; Kay, Suzanne Mahlburg

    2007-09-01

    The Valle del Cura region is characterized by a thick volcanic and volcaniclastic sequence that records the Tertiary arc and backarc magmatic evolution of the Argentine Main Cordillera over the modern Pampean flatslab at 29.5-30°S. During the Eocene, a retroarc basin developed, represented by the Valle del Cura Formation synorogenic volcanosedimentary sequence, which includes rhyolites and dacitic tuffs. These silicic volcanic rocks have weak arc chemical signatures and high lithophile element concentrations and are isotopically enriched relative to the late Oligocene-early Miocene volcanic rocks that followed them. Their chemical characteristics fit with eruption through a thin crust. The Valle de Cura Formation was followed by the Oligocene-early Miocene Doña Ana Group volcanic sequence, which erupted at and near the arc front west of the border with Chile. The Doña Ana Group volcanic rocks have calc-alkaline chemical characteristics consistent with parental magmas forming in a mantle wedge and erupting through a normal thickness crust (35 km). Subsequent shallowing of the downgoing Nazca plate caused the volcanic front to migrate eastward. The volcanic sequences of the middle Miocene Cerro de las Tórtolas Formation erupted at this new arc front, essentially at the Argentine border. Two stages are recognized: an older one (16-14 Ma) in which magmas appear to have erupted through a normal thickness crust (30-35 km) and a younger one (13-10 Ma) in which the steeper REE pattern suggests the magmas last equilibrated with higher pressure residual mineral assemblages in a thicker crust. Isotopic ratios in the younger group are consistent with an increase in original crustal components and crust introduced into the mantle source by forearc subduction erosion. A peak in forearc subduction erosion near 12-10 Ma is consistent with when the main part of the Juan Fernandez Ridge began to subduct beneath the region. In addition to late Miocene Tambo Formation dacitic

  2. 46 CFR 111.105-40 - Additional requirements for RO/RO vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RO/RO vessels. (a) Each RO/RO vessel must meet ABS Steel Vessel Rules (incorporated by reference; see... 1 hazardous location. (c) Where the ventilation requirement of ABS Steel Vessel Rules section...

  3. CoRoTlog

    NASA Astrophysics Data System (ADS)

    Plasson, Ph.

    2006-11-01

    LESIA, in close cooperation with CNES, DLR and IWF, is responsible for the tests and validation of the CoRoT instrument digital process unit which is made up of the BEX and DPU assembly. The main part of the work has consisted in validating the DPU software and in testing the BEX/DPU coupling. This work took more than two years due to the central role of the software tested and its technical complexity. The first task, in the validation process, was to carry out the acceptance tests of the DPU software. These tests consisted in checking each of the 325 requirements identified in the URD (User Requirements Document) and were played in a configuration using the DPU coupled to a BEX simulator. During the acceptance tests, all the transversal functionalities of the DPU software, like the TC/TM management, the state machine management, the BEX driving, the system monitoring or the maintenance functionalities were checked in depth. The functionalities associated with the seismology and exoplanetology processing, like the loading of window and mask descriptors or the configuration of the service execution parameters, were also exhaustively tested. After having validated the DPU software against the user requirements using a BEX simulator, the following step consisted in coupling the DPU and the BEX in order to check that the formed unit worked correctly and met the performance requirements. These tests were conducted in two phases: the first one was devoted to the functional aspects and the tests of interface, the second one to the performance aspects. The performance tests were based on the use of the DPU software scientific services and on the use of full images representative of a realistic sky as inputs. These tests were also based on the use of a reference set of windows and parameters, which was provided by the scientific team and was representative, in terms of load and complexity, of the one that could be used during the observation mode of the CoRoT instrument

  4. Remembering Juan Navia.

    PubMed

    Dasanayake, A P; Li, Y; Maetz, H M; Vermund, S H

    2013-10-01

    Juan Navia died on September 4, 2010. Those who knew him as the director of the University of Alabama's John J. Sparkman Center for International Public Health Education and later the dean of UAB School of Public Health watched him train and shape the next generation of global public health leaders with a kind heart and a firm, but gentle, hand. On this third anniversary of Professor Navia's passing, in response to an invitation from the Journal of Dental Research to write an essay on an educator who influenced the professional trajectories of many people, we have put together an account of some of his contributions and attributes to highlight this remarkable leader's accomplishments in and impact on dental public health and global nutrition.

  5. Conversation with Juan Carlos Negrete.

    PubMed

    Negrete, Juan Carlos

    2013-08-01

    Juan Carlos Negrete is Emeritus Professor of Psychiatry, McGill University; Founding Director, Addictions Unit, Montreal General Hospital; former President, Canadian Society of Addiction Medicine; and former WHO/PAHO Consultant on Alcoholism, Drug Addiction and Mental Health.

  6. Source rock maturation, San Juan sag

    SciTech Connect

    Gries, R.R.; Clayton, J.L.

    1989-09-01

    Kinetic modeling for thermal histories was simulated for seven wells in the San Juan sag honoring measured geochemical data. Wells in the area of Del Norte field (Sec. 9, T40N, R5E), where minor production has been established from an igneous sill reservoir, show that the Mancos Shale source rocks are in the mature oil generation window as a combined result of high regional heat flow and burial by approximately 2,700 m of Oligocene volcanic rocks. Maturation was relatively recent for this area and insignificant during Laramide subsidence. In the vicinity of Gramps field (Sec. 24, T33N, R2E) on the southwest flank of the San Juan sag, these same source rocks are exposed due to erosion of the volcanic cover but appear to have undergone a similar maturation history. At the north and south margins of the sag, two wells (Champlin 34A-13, Sec. 13, T35N, R4.5E; and Champlin 24A-1, Sec. 1, T44N, R5E) were analyzed and revealed that although the regional heat flow was probably similar to other wells, the depth of burial was insufficient to cause maturation (except where intruded by thick igneous sills that caused localized maturation). The Meridian Oil 23-17 South Fork well (Sec. 17, T39N, R4E) was drilled in a deeper part of the San Juan sag, and source rocks were intruded by numerous igneous sills creating a complex maturation history that includes overmature rocks in the lowermost Mancos Shale, possible CO{sub 2} generation from the calcareous Niobrara Member of the Mancos Shale, and mature source rocks in the upper Mancos Shale.

  7. Counseling According to don Juan

    ERIC Educational Resources Information Center

    Pulvino, Charles J.; Lee, James L.

    1975-01-01

    This article specifies a number of precepts put forth by don Juan, a Yaqui Indian sorcerer. It also outlines the consequences of each precept for counselors. The intent is to facilitate the emergence of a new reality for counseling and other helping professions. (Author/BW)

  8. Characterisation of RO fouling in an integrated MBR/RO system for wastewater reuse.

    PubMed

    Moreno, J; Monclús, H; Stefani, M; Cortada, E; Aumatell, J; Adroer, N; De Lamo-Castellví, S; Comas, J

    2013-01-01

    Membrane filtration has gradually gained acceptance as the preferred pre-treatment for reverse osmosis (RO). In this paper, an integrated membrane bioreactor (MBR)/RO system for wastewater reuse treating real sewage water has been evaluated and the RO fouling has been characterised. The MBR achieved low values of organic matter, total nitrogen, PO(4)(3-), total organic carbon, turbidity and conductivity. Filtration with two different RO commercial membranes was performed after the MBR pre-treatment and the same average fouling rate (0.08 bar day(-1)) was noted. These results gained from the characterisation of the high quality MBR/RO permeate show its potential for water reuse. Inorganic precipitation appears to be the predominant form of fouling in the RO membranes. Calcium phosphate and alumino-silicates were identified by a scanning electron microscope combined with an energy dispersive X-ray and polysaccharides, amide and aliphatic structures were detected with attenuated total reflection infrared microspectroscopy.

  9. 77 FR 68146 - Notice of Intent To Prepare an Environmental Impact Statement for the Paseo del Morro National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... National Recreational Trail Extension, San Juan National Historic Site, San Juan, Puerto Rico AGENCY... Environmental Impact Statement for the Paseo del Morro National Recreational Trail Extension (EIS). The EIS will... project are: To create public access to the North Coast of the Old San Juan Islet and create...

  10. Ro(SS-A) and anti-Ro(SS-A): an update.

    PubMed

    Sibilia, J

    1998-01-01

    Anti-Ro/SSA antibodies are the antinuclear antibodies most commonly found in everyday clinical practice and are closely associated with Sjögren's syndrome, systemic lupus erythematosus and neonatal lupus. They play a pathogenic role in a variety of clinical manifestations, including skin lesions and neonatal lupus heart block. Autoantibodies to Ro(SS-A) recognize a ribonucleoprotein complex composed of small single-stranded RNAs (hYRNAs) and of one or more peptides. Four molecular forms of this complex have been differentiated based on the nature of the peptide: a lymphocyte and an erythrocyte Ro with a 60 kDa peptide, a lymphocyte Ro with a 52 kDa peptide and an erythrocyte Ro with a 54 kDa peptide. The Ro complex is found in most tissues and cells (erythrocytes, platelets), with differences in structure and quantity across tissues, species and embryonic development stages. Although its function remains unknown, its ability to bind nucleic acids and the fact that it shares homologies with gene regulation proteins suggest that it may participate in RNA transcription processes. A number of environmental factors (exposure to ultraviolet radiation, viral infections) may cause translocation of the Ro complex to nucleocytoplasmic and membrane sites where it is not normally found, thereby leading to the development of autoimmunity. The structure of the Ro(SS-A)-hYRNA complex and the development of autoimmunity are currently the focus of active research efforts that can be expected to improve our understanding of the clinical manifestations directly related to anti-Ro(SS-A) antibodies.

  11. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: San Juan Harbor, San Juan, PR. 165.754 Section 165.754 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS Specific Regulated Navigation Areas and...

  12. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of...

  13. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of...

  14. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of...

  15. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius

    NASA Astrophysics Data System (ADS)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.

    2009-10-01

    December 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. First CoRoT data are available to the public from the CoRoT archive: http://idoc-corot.ias.u-psud.fr. The complementary observations were obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by NRC in Canada, INSU-CNRS in France, and the University of Hawaii; ESO Telescopes at the La Silla and Paranal Observatories under programme ID 081.C-0413(C), DDT 282.C-5015; the IAC80 telescope operated by the Instituto de Astrofísica de Tenerife at the Observatorio del Teide; the Isaac Newton Telescope (INT), operated on the island of La Palma by the Isaac Newton group in the Spanish Observatorio del Roque de Los Muchachos of the Instituto de Astrofisica de Canarias; and at the Anglo-Australian Telescope that have been funded by the Optical Infrared Coordination network (OPTICON), a major international collaboration supported by the Research Infrastructures Programme of the European Commissions Sixth Framework Programme; Radial-velocity observations were obtained with the SOPHIE spectrograph at the 1.93m telescope of Observatoire de Haute Provence, France.

  16. AstRoMap European Astrobiology Roadmap.

    PubMed

    Horneck, Gerda; Walter, Nicolas; Westall, Frances; Grenfell, John Lee; Martin, William F; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R; Rettberg, Petra; Capria, Maria Teresa

    2016-03-01

    The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems • Research Topic 2: Origins of Organic Compounds in Space • Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life • Research Topic 4: Life and Habitability • Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system.

  17. AstRoMap European Astrobiology Roadmap

    PubMed Central

    Horneck, Gerda; Westall, Frances; Grenfell, John Lee; Martin, William F.; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R.; Rettberg, Petra; Capria, Maria Teresa

    2016-01-01

    Abstract The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems• Research Topic 2: Origins of Organic Compounds in Space• Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life• Research Topic 4: Life and Habitability• Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system. Key Words: Astrobiology roadmap—Europe—Origin and evolution of life—Habitability—Life detection—Life in extreme environments. Astrobiology 16, 201–243. PMID:27003862

  18. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  19. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  20. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  1. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  2. 75 FR 48306 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... comments should be sent to Attn: San Juan National Forest RAC, 15 Burnett Court, Durango, CO...

  3. 76 FR 12692 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... comments should be sent to Attn: San Juan National Forest RAC, 15 Burnett Court, Durango, CO...

  4. 76 FR 40876 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... Sonoran Meeting Rooms. Written comments should be sent to Attn: San Juan National Forest RAC, 15...

  5. Transiting exoplanets from the CoRoT space mission. XXVII. CoRoT-28b, a planet orbiting an evolved star, and CoRoT-29b, a planet showing an asymmetric transit

    NASA Astrophysics Data System (ADS)

    Cabrera, J.; Csizmadia, Sz.; Montagnier, G.; Fridlund, M.; Ammler-von Eiff, M.; Chaintreuil, S.; Damiani, C.; Deleuil, M.; Ferraz-Mello, S.; Ferrigno, A.; Gandolfi, D.; Guillot, T.; Guenther, E. W.; Hatzes, A.; Hébrard, G.; Klagyivik, P.; Parviainen, H.; Pasternacki, Th.; Pätzold, M.; Sebastian, D.; Tadeu dos Santos, M.; Wuchterl, G.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Armstrong, J. D.; Auvergne, M.; Baglin, A.; Barge, P.; Barros, S. C. C.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carpano, S.; Chaffey, C.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Grziwa, S.; Korth, J.; Lammer, H.; Lindsay, C.; Mazeh, T.; Moutou, C.; Ofir, A.; Ollivier, M.; Pallé, E.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.

    2015-07-01

    Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims: We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods: We used the transit light curve to characterize the planetary parameters relative to the stellar parameters. The analysis of HARPS spectra established the planetary nature of the detections, providing their masses. Further photometric and spectroscopic ground-based observations provided stellar parameters (log g, Teff, v sin i) to characterize the host stars. Our model takes the geometry of the transit to constrain the stellar density into account, which when linked to stellar evolutionary models, determines the bulk parameters of the star. Because of the asymmetric shape of the light curve of one of the planets, we had to include the possibility in our model that the stellar surface was not strictly spherical. Results: We present the planetary parameters of CoRoT-28b, a Jupiter-sized planet (mass 0.484 ± 0.087 MJup; radius 0.955 ± 0.066 RJup) orbiting an evolved star with an orbital period of 5.208 51 ± 0.000 38 days, and CoRoT-29b, another Jupiter-sized planet (mass 0.85 ± 0.20 MJup; radius 0.90 ± 0.16 RJup) orbiting an oblate star with an orbital period of 2.850 570 ± 0.000 006 days. The reason behind the asymmetry of the transit shape is not understood at this point. Conclusions: These two new planetary systems have very interesting properties and deserve further study, particularly in the case of the star CoRoT-29. The CoRoT space mission, launched on December 27th 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain. Based on observations obtained with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland

  6. Anti-ENA profiles related with anti-SS-A/Ro. The detection of Ro52 and Ro60 according to the presence of SS-B/La, and ANA pattern and titer.

    PubMed

    González, D Almeida; Rodríguez, C Casañas; Armas, L Magdalena; Varela, A Roces; Rodríguez, I Marcelino; Duarte, M Troche; de León, A Cabrera

    2014-09-01

    Anti-Ro52 (Ro52) and anti-Ro60 (Ro60) antibodies are associated with different clinical entities. We investigated their relationship with the presence of anti-SS-B/La (SSB) antibody, the pattern and titer of antinuclear antibody (ANA), and the variations in antibody profiles related with anti-SS-A/Ro (SSA) positivity. Our aim was to develop a strategy to increase the efficiency of anti-extractable nuclear antigen (ENA) determinations. Statistical analyses were based on the Chi-squared test for categorical variables, the Mann-Whitney U test to compare profiles, and the odds ratio (OR) and 95% confidence interval (95% CI) to estimate the risk of variability. We analyzed 800 SSA-positive samples with Ro52 or Ro60 reactivity. The most frequent profiles were Ro52+Ro60+SSB (n=349, 43.6%); Ro52+Ro60 (n=126, 15.8%); Ro52 (n=121, 15.1%) and Ro60 (n=71, 8.9%). In samples positive only for SSA and an ANA titer ≤1:640, the most likely profile was positivity for either Ro52 or Ro60, whereas when the ANA titer was >1:640, positivity for both Ro52 and Ro60 simultaneously was more likely (p<0.001). In samples positive for both SSA and SSB, the most likely profile was Ro52+Ro60+SSB regardless of the ANA titer (p=0.001). When only SSA was positive and the ANA staining pattern was nucleolar, centromeric or cytoplasmic, Ro52 positivity was most likely (p<0.001). When both SSA and SSB were positive, both Ro52 and Ro60 were likely to be positive regardless of the ANA staining pattern. In 28.7% of the patients the profile was variable. Variability was significantly greater in those with the SSA profile (23/67) than with the SSA+SSB profile (15/105; OR=1.9, 95% CI=1.1-3.3; p=0.025), and the difference in variability was greatest between the Ro52+Ro60 profile (8/23) and the Ro52+Ro60+SSB profile (8/68; OR=4.2, 95% CI=1.9-9.5; p<0.001). We conclude that to increase efficiency in the immunology laboratory, positivity for Ro52 and Ro60 individually or simultaneously can be deduced from SSB

  7. An Introduction to the RoLI[TM

    ERIC Educational Resources Information Center

    Meyer, Jan H. F.

    2004-01-01

    The Reflections on Learning Inventory (RoLI) is an instrument designed to capture variation in students' engagement of learning--typically in a given disciplinary context or topic-specific 'episode'. Although the RoLI has been employed as a research instrument in a number of published studies on the modelling of student learning in higher…

  8. RoMPS concept review automatic control of space robot

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Robot operated Material Processing in Space (RoMPS) experiment is being performed to explore the marriage of two emerging space commercialization technologies: materials processing in microgravity and robotics. This concept review presents engineering drawings and limited technical descriptions of the RoMPS programs' electrical and software systems.

  9. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a Ro-Ro ramp shall be plainly marked with its weight in pounds (kilograms). Alternatively, the cargo stow plan or equivalent record containing the actual gross weight of the load may be used to determine...

  10. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a Ro-Ro ramp shall be plainly marked with its weight in pounds (kilograms). Alternatively, the cargo stow plan or equivalent record containing the actual gross weight of the load may be used to determine...

  11. Recent standardization activities on radio on fiber (RoF)

    NASA Astrophysics Data System (ADS)

    Ogawa, Hiroyo; Kuri, Toshiaki; Kanno, Atsushi; Kawanishi, Tetsuya

    2013-12-01

    The Radio on Fiber (RoF) technologies are unique transmission means of radio analog signals through optical fiber cables. These technologies are currently discussed at international standard organizations such as ITU-T, IEC, APT and IEEE802. This invited paper summarizes RoF standardization activities at those standard organizations.

  12. SyRoTek--Distance Teaching of Mobile Robotics

    ERIC Educational Resources Information Center

    Kulich, M.; Chudoba, J.; Kosnar, K.; Krajnik, T.; Faigl, J.; Preucil, L.

    2013-01-01

    E-learning is a modern and effective approach for training in various areas and at different levels of education. This paper gives an overview of SyRoTek, an e-learning platform for mobile robotics, artificial intelligence, control engineering, and related domains. SyRoTek provides remote access to a set of fully autonomous mobile robots placed in…

  13. 9 years of existence of the site astronomy.ro

    NASA Astrophysics Data System (ADS)

    Haus, Marian

    2013-06-01

    The article represents a history of the Astronomical site: http://www.astronomy.ro and its forum http://www.astronomy.ro/forum/. To the actual moment about 1700 members - amateur astronomers from every where in Romania and outside - contribute to this site and forum. The main areas of interst are: Astronomical Instruments, Astrophotography, Eclipses, Solar Astronomy, Comets, Asteroids and Meteors, Optics.

  14. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a...

  15. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a...

  16. Cesáro partial sums of concave univalent functions

    NASA Astrophysics Data System (ADS)

    Aldawish, Ibtisam; Darus, Maslina

    2014-06-01

    In this article, we consider the Cesáro partial sums of certain concave univalent functions. We studied geometric properties of the Cesáro partial sums of certain concave univalent functions in the open unit disk. Examples are illustrated.

  17. Don Juan and the vision of Vision.

    PubMed

    Smith, C U

    1981-01-01

    Castaneda's well-known sequence of Don Juan books is used as a paradigmatic example of the relativist position. Central to Don Juan's teaching is the problem of perception: the main task, he constantly reiterates, is simply to 'see', to recognise that the commonsense world we customarily perceive is nothing more than a cultural construct. To combat this thoroughgoing relativism a case study is taken from the early history of visual science. In classical antiquity several fundamentally different 'views' (to use Don Juan's term) of how we see contended for approval. It was only at the beginning of the seventeenth century that the 'modern' interpretation was selected. This interpretation was selected, ultimately, because it 'worked'. Reference is made to both Wittgenstein and Marx to support this appeal to praxis. It is argued that through an intricate, complex, and ill-understood process of popularisation our self-image is ultimately grounded in the theories of natural science; and these, in turn, are ultimately grounded in our action in the world of things.

  18. Photometric variability of the Be star CoRoT-ID 102761769

    NASA Astrophysics Data System (ADS)

    Emilio, M.; Andrade, L.; Janot-Pacheco, E.; Baglin, A.; Gutiérrez-Soto, J.; Suárez, J. C.; de Batz, B.; Diago, P.; Fabregat, J.; Floquet, M.; Frémat, Y.; Huat, A. L.; Hubert, A. M.; Espinosa Lara, F.; Leroy, B.; Martayan, C.; Neiner, C.; Semaan, T.; Suso, J.

    2010-11-01

    Context. Classical Be stars are rapid rotators of spectral type late O to early A and luminosity class V-III, which exhibit Balmer emission lines and often a near infrared excess originating in an equatorially concentrated circumstellar envelope, both produced by sporadic mass ejection episodes. The causes of the abnormal mass loss (the so-called Be phenomenon) are as yet unknown. Aims: For the first time, we can now study in detail Be stars outside the Earth's atmosphere with sufficient temporal resolution. We investigate the variability of the Be Star CoRoT-ID 102761769 observed with the CoRoT satellite in the exoplanet field during the initial run. Methods: One low-resolution spectrum of the star was obtained with the INT telescope at the Observatorio del Roque de los Muchachos. A time series analysis was performed using both cleanest and singular spectrum analysis algorithms to the CoRoT light curve. To identify the pulsation modes of the observed frequencies, we computed a set of models representative of CoRoT-ID 102761769 by varying its main physical parameters inside the uncertainties discussed. Results: We found two close frequencies related to the star. They are 2.465 c d-1 (28.5 μHz) and 2.441 c d-1 (28.2 μHz). The precision to which those frequencies were found is 0.018 c d-1 (0.2 μHz). The projected stellar rotation was estimated to be 120 km s-1 from the Fourier transform of spectral lines. If CoRoT-ID 102761769 is a typical Galactic Be star it rotates near the critical velocity. The critical rotation frequency of a typical B5-6 star is about 3.5 c d-1 (40.5 μHz), which implies that the above frequencies are really caused by stellar pulsations rather than star's rotation. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  19. Highlights on Novel Technologies for the Detection of Antibodies to Ro60, Ro52, and SS-B

    PubMed Central

    Infantino, M.; Bentow, C.; Seaman, A.; Benucci, M.; Atzeni, F.; Sarzi-Puttini, P.; Olivito, B.; Meacci, F.; Manfredi, M.; Mahler, M.

    2013-01-01

    Objective. We aimed to compare a chemiluminescent immunoassay (CIA, QUANTA Flash) on BIO-FLASH with a multiplex flow immunoassay (MFI) on BioPlex 2200 for the detection of antibodies to Ro60, Ro52, and SS-B. Methods. The study included 241 samples, from patients suffering from systemic autoimmune diseases (n = 108) as well as disease controls (n = 133). All samples were tested for anti-Ro52, anti-Ro60, and anti-SS-B (La) antibodies on QUANTA Flash (INOVA Diagnostics, San Diego, USA) and BioPlex 2200 (Bio-Rad Laboratories Inc., Hercules, USA). Discrepant samples were tested by two independent methods: BlueDot/ANA and QUANTRIX Microarray (both D-tek, Belgium). Results. The overall qualitative agreements were 95.4% (95% confidence interval, CI 92.0–97.7%) for anti-Ro52, 98.8% (95% CI 96.4–99.7%) for anti-Ro60, and 91.7% (95% CI 87.5–94.9%) for anti-SS-B antibodies. There were 34 discrepant samples among all assays (20 anti-SS-B, 11 anti-Ro52, 3 anti-Ro60). 30/33 of retested samples (by D-tek dot blot) agreed with the QUANTA Flash results. Similar findings were obtained with QUANTRIX Microarray kit. Conclusion. QUANTA Flash and BioPlex 2200 show good qualitative agreement. The clinical performances were similar for anti-Ro52 and anti-Ro60 autoantibodies while differences were observed for anti-SS-B (La) antibodies. PMID:24376466

  20. Correction to Clark and Ro (2014).

    PubMed

    2015-01-01

    Reports an error in "Three-pronged assessment and diagnosis of personality disorder and its consequences: Personality functioning, pathological traits, and psychosocial disability" by Lee Anna Clark and Eunyoe Ro (Personality Disorders: Theory, Research, and Treatment, 2014[Jan], Vol 5[1], 55-69). There was an error in the results. Under the subheading, Personality Traits-Functioning Relations, on page 63, the second, third, and fourth paragraph have been revised. The revisions are included in the erratum. (The following abstract of the original article appeared in record 2014-07188-003.) The alternative dimensional model of personality disorder (PD) in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association, 2013), Section III, has two main criteria: impairment in personality functioning and one or more pathological personality traits. The former is defined as disturbances in self-functioning (viz., identity, self-direction), and/or interpersonal functioning (viz., empathy, intimacy). Distinguishing personality functioning and traits is important conceptually, because simply having extreme traits is not necessarily pathological. However, adding personality functioning to PD diagnosis represents an empirical challenge, because the constructs overlap conceptually. Further, there is debate regarding whether diagnosis of mental disorder requires either distress or disability, concepts that also overlap with maladaptive-range personality traits and personality dysfunction. We investigated interrelations among these constructs using multiple self-report measures of each domain in a mixed community-patient sample (N = 402). We examined the structures of functioning (psychosocial disability and personality) and personality traits, first independently, then jointly. The disability/functioning measures yielded the 3 dimensions we have found previously (Ro & Clark, 2013). Trait measures had a hierarchical structure

  1. [Juan Valverde de Amusco c. 1525-1588 and his vocation for anatomy in the Hispano-Italian Renaissance].

    PubMed

    Hernández-Mansilla, José Miguel

    2015-01-01

    The XVIth century witnessed a glorious period in the progress of some of the basic medical sciences among which anatomy stands out. One of the well-known figures involved in the development of this subject was Juan Valverde de Amusco, a notable Spanish scientist. This research shows the most relevant data currently known on his life, sociocultural environment and his celebrated treaty on anatomy titled: "Historia de la composición del cuerpo humano". (History of the human body).

  2. Chinanteco de San Juan Lealao, Oaxaca (Chinantec of San Juan Lealao, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Chinantec, an indigenous language of Mexico spoken in San Juan Lealao, in the state of Oaxaca. The objective of collecting such a representative sampling of…

  3. Trique de San Juan Copala, Oaxaca (Trique of San Juan Copala, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Trique, an indigenous language of Mexico spoken in San Juan Copala, in the state of Oaxaca. The objective of collecting such a representative sampling of the…

  4. Una Visita al Viejo San Juan (A Visit to Old San Juan).

    ERIC Educational Resources Information Center

    Cabello, Victor; And Others

    Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

  5. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Strait of Juan de Fuca. 80.1385 Section 80.1385 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of...

  6. 77 FR 47358 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... recommendations to the Forest Service concerning projects and funding consistent with Title II of the Act....

  7. Juan's Dilemma: A New Twist on the Old Lemon Battery

    ERIC Educational Resources Information Center

    Hunt, Vanessa; Sorey, Timothy; Balandova, Evguenia; Palmquist, Bruce

    2010-01-01

    When life hands you lemons, make a battery! In this article, the authors describe an activity they refer to as "Juan's Dilemma," an extension of the familiar lemon-battery activity (Goodisman 2001). Juan's Dilemma integrates oxidation and reduction chemistry with circuit theory in a fun, real-world exercise. The authors designed this activity for…

  8. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the...

  9. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the...

  10. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the...

  11. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the...

  12. Assuring the Legacy of the CoRoT Planets

    NASA Astrophysics Data System (ADS)

    Deeg, H. J.; Klagyivik, P.; Alonso, R.; Hoyer, S.

    2015-09-01

    For the long-lasting impact of CoRoT's planet findings, precise knowledge of the times of their transits is of vital importance for any future observing campaigns. Here we give the motivation and first results of a systematic revisit of the transits of most CoRoT planets to refine their ephemeris. As secondary objectives, more precise planet characterisations, from period or transit shape variations on/and from use of a well-defined passband may be obtained.

  13. Transiting exoplanets from the CoRoT space mission. XVII. The hot Jupiter CoRoT-17b: a very old planet

    NASA Astrophysics Data System (ADS)

    Csizmadia, Sz.; Moutou, C.; Deleuil, M.; Cabrera, J.; Fridlund, M.; Gandolfi, D.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Carone, L.; Carpano, S.; Cavarroc, C.; Cochran, W.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Endl, M.; Erikson, A.; Ferraz-Mello, S.; Fruth, Th.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

    2011-07-01

    We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of 2.43 ± 0.30 MJup and a radius of 1.02 ± 0.07 RJup, while its mean density is 2.82 ± 0.38 g/cm3. CoRoT-17b is in a circular orbit with a period of 3.7681 ± 0.0003 days. The host star is an old (10.7 ± 1.0 Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain ~380 earth masses of heavier elements. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  14. VizieR Online Data Catalog: CoRoT/Exoplanet fields with MATISSE (Gazzano+, 2010)

    NASA Astrophysics Data System (ADS)

    Gazzano, J.-C.; de Laverny, P.; Deleuil, M.; Recio-Blanco, A.; Bouchy, F.; Moutou, C.; Bijaoui, A.; Ordenovic, C.; Gandoli, D.; Loeillet, B.

    2010-11-01

    Atomic data modifications from VALD initial request, atmospheric parameters for 1227 CoRoT targets, radial velocity for 1534 CoRoT targets, and Vsini for 1604 CoRoT targets in three CoRoT/Exoplanet fields LRa01, LRc01, and SRc01. The reported uncertainties are only internal errors. (6 data files).

  15. Higher order multi-dimensional extensions of Cesàro theorem

    NASA Astrophysics Data System (ADS)

    Accardi, Luigi; Ji, Un Cig; Saitô, Kimiaki

    2015-12-01

    The Cesàro theorem is extended to the cases: (1) higher order Cesàro mean for sequence (discrete case); and (2) higher order, multi-dimensional and continuous Cesàro mean for functions. Also, we study the Cesàro theorem for the case of positive-order.

  16. Model Simulations of Waves in Hurricane Juan

    NASA Astrophysics Data System (ADS)

    Perrie, W.; Toulany, B.; Padilla-Hernandez, R.; Hu, Y.; Smith, P.; Zhang, W.; Zou, Q.; Ren, X.

    2004-05-01

    Hurricane Juan made landfall at 0300 UTC near Halifax Nova Scotia. This was a category 2 hurricane with winds of 44 m/s, the largest storm to pass over these coastal areas in several decades. Associated high ocean waves were experienced in coastal waters, from Peggy's Cove to Sheet Harbour, growing to epic proportions on the Scotian Shelf, and exceeding the 100-year return wave based on the present climatology. As part of the GoMOOS program (Gulf of Maine Ocean Observing System, www.gomoos.org), winds from the USA Navy COAMPS (Coupled Ocean Atmosphere Model Prediction System) were used to evaluate and compare three widely-used third generation numerical wave models, SWAN, WAM and WaveWatch-III (hereafter WW3) for accuracy, with in situ measurements. Model comparisons consist of a set of composite model systems, respectively nesting WAM, WW3 and SWAN in WAM and WW3. We report results from the intermediate-resolution grid for Hurricane Juan. Wave measurements were made using four operational deep-water buoys (C44258, C44142, C44137, 44005), by a conventional directional wave rider (DWR) moored offshore from Lunenburg Bay, and also by two acoustic Doppler current profiler (ADCP) located (1) near an oil rig on Sable Island Bank, in relatively shallow water, and (2) near the outer boundary of Lunenburg Bay. We discuss the reliability of DWR wave data compared to ADCP wave data. We show that all models provide reliable hindcasts for significant wave height (Hs) and for peak period (Tp) for Juan, although a clear under-estimation of Hs at the peak of the storm is evident, compared to observations. A feature in the COAMPS storm simulation is that the storm track appears to be slightly to the east of that of Quikscat scatterometer data. Comparisons between models and 2-dimensional wave spectra are presented. Preliminary results suggest that the recently released upgrade to the WW3 model shows slightly enhanced skill compared to the other models.

  17. CoRoT: Harvest of the exoplanet program

    NASA Astrophysics Data System (ADS)

    Moutou, Claire; Deleuil, Magali; Guillot, Tristan; Baglin, Annie; Bordé, Pascal; Bouchy, Francois; Cabrera, Juan; Csizmadia, Szilárd; Deeg, Hans J.

    2013-11-01

    One of the objectives of the CoRoT mission is the search for transiting extrasolar planets using high-precision photometry, and the accurate characterization of their fundamental parameters. The CoRoT satellite consecutively observes crowded stellar fields since February 2007, in high-cadence precise photometry; periodic eclipses are detected and analyzed in the stellar light curves. Then complementary observations using ground-based facilities allows establishing the nature of the transiting body and its mass. CoRoT has acquired more than 163,000 light curves and detected about 500 planet candidates. A fraction of them (5%) are confirmed planets whose masses are independently measured. Main highlights of the CoRoT discoveries are: (i) the variety of internal structures in close-in giant planets, (ii) the characterization of the first known transiting rocky planet, CoRoT-7b, and (iii) multiple constraints on the formation, evolution, role of tides in planetary systems.

  18. RadNet Air Data From San Juan, PR

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for San Juan, PR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  19. Evaluation of RO modules for the SSP ETC/LSS.

    NASA Technical Reports Server (NTRS)

    Jasionowski, W. J.; Bambenek, R. A.

    1973-01-01

    During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

  20. Juan-Ron fever: A rare case report.

    PubMed

    Acharya, Sourya; Shukla, Samarth

    2015-01-01

    Juan-Ron fever named after Juan Rosai and Ronald Dorfman is the fever associated with Rosai-Dorfman disease also known as sinus histiocytosis with massive lymphadenopathy (SHML). It is a rare disorder of unknown etiology that is characterized by abundant macrophages in the lymph nodes throughout the body. Usually patient presents with painless lymphadenopathy. We present a case of a 45-year-old male who presented to us with bilateral cervical lymphadenopathy and fever, later on diagnosed to have SHML.

  1. Asteroseismology of OB stars with CoRoT

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Samadi, R.; Miglio, A.; Briquet, M.; Auvergne, M.; Baglin, A.; Baudin, F.; Catala, C.; Michel, E.

    2010-12-01

    The CoRoT satellite is revolutionizing the photometric study of massive O-type and B-type stars. During its long runs, CoRoT observed the entire main sequence B star domain, from typical hot β Cep stars, via cooler hybrid p- and g-mode pulsators to the SPB stars near the edge of the instability strip. CoRoT lowers the sensitivity barrier from the typical mmag-precision reached from the ground, to the μmag-level reached from space. Within the wealth of detected and identified pulsation modes, relations have been found in the form of multiplets, combination of frequencies, and frequency- and period spacings. This wealth of observational evidence is finally providing strong constraints to test current models of the internal structure and pulsations of hot stars. Aside from the expected opacity driven modes with infinite lifetime, other unexpected types of variability are detected in massive stars, such as modes of stochastic nature. The simultaneous observation of all these light curve characteristics implies a challenge for both observational asteroseismology and stellar modelling. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  2. StRoBe: A Classroom-on-Task Measure.

    ERIC Educational Resources Information Center

    Marchant, Gregory J.

    Researchers as well as others evaluating teachers or programs are often interested in the verbal and non-verbal behaviors related to the learning of students in classrooms. The Student Record of Behavior (StRoBe) is a classroom observation instrument designed to provide simple low inference information concerning student behaviors related to…

  3. Removing Arsenic with a Softening/RO Combo

    EPA Science Inventory

    This paper provides a very short summary of the arsenic demonstration program and the limited test results from the point-of-use (POU), reverse osmosis (RO) project in Homedale, ID. Preformance data is presented on the effectiveness of the POU treatment system to remove arseni...

  4. AmeriFlux US-Ro1 Rosemount- G21

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota; Griffis, Timothy [University of Minnesota

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro1 Rosemount- G21. Site Description - This tower is located in a farm field farmed in accordance with the dominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  5. AmeriFlux US-Ro3 Rosemount- G19

    DOE Data Explorer

    Baker, John [USDA-ARS; Griffis, Tim [University of Minnesota

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro3 Rosemount- G19. Site Description - This tower is located in a farm field farmed in accordance with the cominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  6. Isotretinoin (Ro-Accutane) teratogenesis. A case report.

    PubMed

    Giannoulis, C H; Papathanasiou, K; Tantanasis, T H; Vaitsi, V; Tzafettas, I

    2005-01-01

    A case of teratogenesis in a 16-year-old pregnant patient is described. She had been using 60 mg Ro-Accutane daily till the 16th week of gestation. Sonography showed no cephalic skull up to the frontal bone of the fetus. A central lagostroma was also detected.

  7. Empirical Error Analysis of GPS RO Atmospheric Profiles

    NASA Astrophysics Data System (ADS)

    Scherllin-Pirscher, B.; Steiner, A. K.; Foelsche, U.; Kirchengast, G.; Kuo, Y.

    2010-12-01

    In the upper troposphere and lower stratosphere (UTLS) region the radio occultation (RO) technique provides accurate profiles of atmospheric parameters. These profiles can be used in operational meteorology (i.e., numerical weather prediction), atmospheric and climate research. We present results of an empirical error analysis of GPS RO data retrieved at UCAR and at WEGC and compare data characteristics of CHAMP, GRACE-A, and Formosat-3/COSMIC. Retrieved atmospheric profiles of bending angle, refractivity, dry pressure, dry geopotential height, and dry temperature are compared to reference profiles extracted from ECMWF analysis fields. This statistical error characterization yields a combined (RO observational plus ECMWF model) error. We restrict our analysis to the years 2007 to 2009 due to known ECMWF deficiencies prior to 2007 (e.g., deficiencies in the representation of the austral polar vortex or the weak representation of tropopause height variability). The GPS RO observational error is determined by subtracting the estimated ECMWF error from the combined error in terms of variances. Our results indicate that the estimated ECMWF error and the GPS RO observational error are approximately of the same order of magnitude. Differences between different satellites are small below 35 km. The GPS RO observational error features latitudinal and seasonal variations, which are most pronounced at stratospheric altitudes at high latitudes. We present simplified models for the observational error, which depend on a few parameters only (Steiner and Kirchengast, JGR 110, D15307, 2005). These global error models are derived from fitting simple analytical functions to the GPS RO observational error. From the lower troposphere up to the tropopause, the model error decreases closely proportional to an inverse height law. Within a core "tropopause region" of the upper troposphere/lower stratosphere the model error is constant and above this region it increases exponentially with

  8. Cesàro operators on Hardy spaces in the unit ball

    NASA Astrophysics Data System (ADS)

    Guo, Xiaoqin; Ren, Guangbin

    2008-03-01

    This article establishes the boundedness of the generalized Cesàro operator on holomorphic Hardy spaces in the unit ball. The approach consists in writing the generalized Cesàro operator as a composition of certain integral operators.

  9. Comparison of antibody assays for detection of autoantibodies to Ro 52, Ro 60 and La associated with primary Sjögren's syndrome.

    PubMed

    Trier, Nicole Hartwig; Nielsen, Inger Ødum; Friis, Tina; Houen, Gunnar; Theander, Elke

    2016-06-01

    Anti-Ro(52/60) and anti-La constitute the hallmark autoantibodies in primary Sjögren's syndrome, being present in 40-70% of sera. Several anti-Ro/La assays exist, but antibody detection appears to be assay-specific, thus the aim of this study was to compare several anti-Ro/La assays. In total, 96 sera from individuals with primary Sjögren's syndrome and 114 healthy controls were tested for anti-Ro 52/60 and anti-La in 17 immunoassays. Especially the immunoassays used for detection of anti-Ro 52 differed in their sensitivity (48-79%), while only small differences in sensitivities were observed for the anti-Ro 60 (69-77%) anti-La (39-44%) assays. Concordances of 65%, 79% and 73% for the anti-Ro 52, anti-Ro 60 and anti-La assays were found, respectively. The majority of the assays yielded high specificities, primarily ranging from 97 to 100%, except from a single anti-Ro 60 assay, which yielded a specificity of 79%. Occasionally, reactivity levels were increased in a few assays, indicating that false-positive results can be obtained when applying assays of reduced specificity. In general, the commercial assays appeared to perform better than the in-house analyses. When correcting the in-house assays for background reactivity, sensitivities were reduced by approximately 7%, 17%, and 19% for anti-Ro 52, anti-Ro 60 and anti-La assays, respectively, illustrating the pitfalls when applying immunoassays for detection of autoantibodies, which in theory may apply to commercial assays as well. Finally, increased total sensitivities were obtained when combining assays. These studies contribute to clarify the clinical utility of immunoassays for detection of autoantibodies of Ro 52, Ro 60 and La and illustrate that the most efficient strategy to maximize antibody sensitivity is to combine several assays.

  10. Gene encoding human Ro-associated autoantigen Y5 RNA.

    PubMed Central

    Maraia, R; Sakulich, A L; Brinkmann, E; Green, E D

    1996-01-01

    Ro ribonucleoproteins are composed of Y RNAs and the Ro 60 kDa protein. While the Ro 60 kDa protein is implicated in an RNA discard pathway that recognizes 3'-extended 5S rRNAs, the function of Y RNAs remains unknown [O'Brien,C.A. and Wolin,S.L. (1995) Genes Dev. 8,2891-2903]. Y5 RNA occupies a large fraction of Ro 60 kDa protein in human Ro RNPs, contains an atypical 3'-extension not found on other Y RNAs, and constitutes an RNA antigen in certain autoimmune patients [Boulanger et al. (1995) Clin. Exp. Immunol. 99, 29-36]. An overabundance of Y RNA retroposed pseudogenes has previously complicated the isolation of mammalian Y RNA genes. The source gene for Y5 RNA was isolated from human DNA as well as from Galago senegalis DNA. Authenticity of the hY5 RNA gene was demonstrated in vivo and its activity was compared with the hY4 RNA gene that also uses a type 3 promoter for RNA polymerase III. The hY5 RNA gene was subsequently found to reside within a few hundred thousand base pairs of other Y RNA genes and the linear order of the four human Y RNA genes on chromosome 7q36 was determined. Phylogenetic comparative analyses of promoter and RNA structure indicate that the Y5 RNA gene has been subjected to positive selection during primate evolution. Consistent with the proposal of O'Brien and Harley [O'Brian,C.A. and Wolin,S.L. (1992) Gene 116, 285-289], analysis of flanking sequences suggest that the hY5 RNA gene may have originated as a retroposon. PMID:8836182

  11. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  12. 33 CFR 167.1312 - In the Strait of Juan de Fuca: Southern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1312 In the Strait of Juan de Fuca: Southern lanes. In the southern lanes of the Strait of Juan de Fuca, the following...

  13. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  14. 33 CFR 167.1314 - In the Strait of Juan de Fuca: Eastern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1314 In the Strait of Juan de Fuca: Eastern lanes. In the eastern lanes of the Strait of Juan de Fuca, the following are...

  15. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  16. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  17. 33 CFR 167.1313 - In the Strait of Juan de Fuca: Northern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1313 In the Strait of Juan de Fuca: Northern lanes. In the northern lanes of the Strait of Juan de Fuca, the following...

  18. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  19. 33 CFR 167.1314 - In the Strait of Juan de Fuca: Eastern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1314 In the Strait of Juan de Fuca: Eastern lanes. In the eastern lanes of the Strait of Juan de Fuca, the following are...

  20. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  1. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  2. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  3. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  4. 33 CFR 167.1312 - In the Strait of Juan de Fuca: Southern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1312 In the Strait of Juan de Fuca: Southern lanes. In the southern lanes of the Strait of Juan de Fuca, the following...

  5. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  6. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  7. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  8. 33 CFR 167.1313 - In the Strait of Juan de Fuca: Northern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1313 In the Strait of Juan de Fuca: Northern lanes. In the northern lanes of the Strait of Juan de Fuca, the following...

  9. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  10. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  11. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  12. The Forts of Old San Juan: Guardians of the Caribbean. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Weltzin, Rosanna

    The massive masonry defenses of Old San Juan, Puerto Rico, which were begun in the 16th century, exist today as the oldest European-style fortifications within the territory of the United States. This lesson is based on the World Heritage Site nomination file and the National Park Service Handbook, "San Juan: The Forts of Old San Juan."…

  13. Stellar classification of CoRoT targets

    NASA Astrophysics Data System (ADS)

    Damiani, C.; Meunier, J.-C.; Moutou, C.; Deleuil, M.; Ysard, N.; Baudin, F.; Deeg, H.

    2016-11-01

    Context. The CoRoT mission was the first dedicated to the search for exoplanets from space. The CoRoT exoplanet channel observed about 163 600 targets to detect transiting planetary companions. In addition to the search for exoplanets, the extremely precise photometric time series provided by CoRoT for this vast number of stars is an invaluable resource for stellar studies. Because CoRoT targets are faint (11 ≤ r ≤ 16) and close to the galactic plane, only a small subsample has been observed spectroscopically. Consequently, the stellar classification of CoRoT targets required the design of a classification method suited for the needs and time frame of the mission. Aims: We describe the latest classification scheme used to derive the spectral type of CoRoT targets, which is based on broadband multi-colour photometry. We assess the accuracy of this spectral classification for the first time. Methods: We validated the method on simulated data. This allows the quantification of the effect of different sources of uncertainty on the spectral type. Using galaxy population synthesis models, we produced a synthetic catalogue that has the same properties as the CoRoT targets. In this way, we are able to predict typical errors depending on the estimated luminosity class and spectral type. We also compared our results with independent estimates of the spectral type. Cross-checking those results allows us to identify the systematics of the method and to characterise the stellar populations observed by CoRoT. Results: We find that the classification method performs better for stars that were observed during the mission-dedicated photometric ground-based campaigns.The luminosity class is wrong for less than 7% of the targets. Generally, the effective temperature of stars classified as early type (O, B, and A) is overestimated. Conversely, the temperature of stars classified as later type tends to be underestimated. This is mainly due to the adverse effect of interstellar

  14. LOD First Estimates In 7406 SLR San Juan Argentina Station

    NASA Astrophysics Data System (ADS)

    Pacheco, A.; Podestá, R.; Yin, Z.; Adarvez, S.; Liu, W.; Zhao, L.; Alvis Rojas, H.; Actis, E.; Quinteros, J.; Alacoria, J.

    2015-10-01

    In this paper we show results derived from satellite observations at the San Juan SLR station of Felix Aguilar Astronomical Observatory (OAFA). The Satellite Laser Ranging (SLR) telescope was installed in early 2006, in accordance with an international cooperation agreement between the San Juan National University (UNSJ) and the Chinese Academy of Sciences (CAS). The SLR has been in successful operation since 2011 using NAOC SLR software for the data processing. This program was designed to calculate satellite orbits and station coordinates, however it was used in this work for the determination of LOD (Length Of Day) time series and Earth Rotation speed.

  15. Physiography and Quaternary geology of the San Juan Mountains, Colorado

    USGS Publications Warehouse

    Atwood, Wallace W.; Mather, Kirtley F.

    1932-01-01

    appeared from time to time as folios"' of the Geologic Atlas and reports on the economic geology of the mining districts, published by the United States Geological Survey between 1899 and 1910. Gradually the concept of the geologic problems was changed. Instead of considering individual mining districts as the units of investigation it became apparent that the San Juan region must itself be the unit. In 1908 Mr. Cross drafted plans for the completion of the San Juan studies on this enlarged basis. His aim was to arrange for the publication of papers on different subjects rather than one huge monograph on the region as a whole.

  16. THE MASS OF CoRoT-7b

    SciTech Connect

    Hatzes, Artie P.; Wuchterl, Guenther; Fridlund, Malcolm; Gandolfi, Davide; Nachmani, Gil; Mazeh, Tsevi; Valencia, Diana; Hebrard, Guillaume; Borde, Pascal; Carone, Ludmila; Paetzold, Martin; Udry, Stephane; Bouchy, Francois; Deleuil, Magali; Moutou, Claire; Barge, Pierre; Deeg, Hans; Tingley, Brandon; Dvorak, Rudolf; Ferraz-Mello, Sylvio E-mail: malcolm.fridlund@esa.int; and others

    2011-12-10

    The mass of CoRoT-7b, the first transiting super-Earth exoplanet, is still a subject of debate. A wide range of masses have been reported in the literature ranging from as high as 8 M{sub Circled-Plus} to as low as 2.3 M{sub Circled-Plus }. This range in mass is largely due to the activity level of the star that contributes a significant amount of radial velocity (RV) 'jitter' and how the various methods correct this jitter. Although most mass determinations give a density consistent with a rocky planet, the lower value permits a bulk composition that can be up to 50% water. We present an analysis of the CoRoT-7b RV measurements that uses very few and simple assumptions in treating the activity signal. By analyzing those RV data for which multiple measurements were made in a given night, we remove the activity related RV contribution without any a priori model. We argue that the contribution of activity to the final RV curve is negligible and that the K-amplitude due to the planet is well constrained. This yields a mass of 7.42 {+-} 1.21 M{sub Circled-Plus} and a mean density of {rho} = 10.4 {+-} 1.8 gm cm{sup -3}. CoRoT-7b is similar in mass and radius to the second rocky planet to be discovered, Kepler-10b, and within the errors they have identical bulk densities-they are virtual twins. These bulk densities lie close to the density-radius relationship for terrestrial planets similar to what is seen for Mercury. CoRoT-7b and Kepler-10b may have an internal structure more like Mercury than the Earth.

  17. Climate Change detection using GPS RO and CMIP5 data

    NASA Astrophysics Data System (ADS)

    Molodtsov, S.; Kirilenko, A.; Olsen, D.

    2013-12-01

    General circulation models' (GCMs) response to the increase of atmospheric concentration of greenhouse gases (GHG) due to anthropogenic emissions is evident under variety of forcing scenarios. However the investigation of the anthropogenic signal in the real climate system is challenging as it requires long term high accuracy global coverage data. GPS Radio Occultation (GPS RO) technique becomes close to meeting all of these requirements, becoming the benchmark for climate data. We implemented the analysis for upper troposphere - lower stratosphere (UTLS) region between 50°N and 50°S latitudes, where the GPS RO data has higher quality. For observations, we used vertical profiles of temperature and/or geopotential heights from 2001-2008 CHAMP and 2006-2011 COSMIC occultation. GCM trends of the response patterns to the external forcings of respective climate variables were extracted from CMIP 5 GCM runs under representative concentration pathways (RCP) 8.5 and historical climate scenarios, for the same period. Natural variability was calculated using CMIP 5 GCM runs under preindustrial control scenario. The GPS RO data was downloaded from CDAAC website, GCM CMIP 5 data was obtained from Earth System Grid web page. We used optimal fingerprinting method which is generalized multivariate regression adjusted for climate change detection studies. Optimal fingerprinting allows estimating of the climate signal separately from natural climate variability. Following this methodology we applied Empirical Orthogonal Functions to filter observed and modeled data in order to decrease impact of natural variability and maximize the signal to noise ratio. Temperature and geopotential height trends in the simulated and observed climate datasets show similar features of warming of the upper troposphere and cooling of the lower stratosphere in the tropics region. Using optimal fingerprinting we found that the anthropogenic signal emerges from natural variability in GPS RO temperature

  18. On the geometric properties of Cesàro spaces

    NASA Astrophysics Data System (ADS)

    Astashkin, Sergey V.

    2012-04-01

    It is proved that the Cesàro space \\operatorname{Ces}_{p} \\lbrack 0,1 \\rbrack , 1\\le p<\\infty, contains a complemented subspace isomorphic to l^q if and only if either q=1 or q=p. A class of subspaces of this space that contain complemented copies of the space l^p is distinguished. Bibliography: 16 titles.

  19. High performance RO membranes for desalination and wastewater reclamation and their operation results.

    PubMed

    Henmi, M; Fusaoka, Y; Tomioka, H; Kurihara, M

    2010-01-01

    Reverse osmosis (RO) membrane is one of the most powerful tools for solving the global water crisis, and is used in a variety of water treatment scenes such as drinking water purification, waste-water treatment, boiler feed water production, ultra pure water production for semiconductor industry, etc. The desired performance of RO membrane varies according to quality of feed water being treated, and Toray has been developing RO membranes with suitable characteristic for each operating condition. RO membranes for seawater desalination and wastewater reclamation are especially regarded as most promising targets. Recently, high boron removal and energy saving RO membrane for seawater desalination and low fouling RO membrane for wastewater reclamation have been developed. In this paper, the prospect of attaining these renovative RO membrane, and furthermore, job references will be discussed.

  20. Sensitization by SR-2508 plus Ro 03-8799

    SciTech Connect

    Stone, H.B.; Luu, Y.H.; Lam, K.N.

    1986-07-01

    The primary toxicity of Ro 03-8799 is a central nervous system toxicity, whereas that of SR-2508 is a peripheral neuropathy. The feasibility of reducing overall toxicity while maintaining maximal radiosensitization by using the two sensitizers together was tested. The LD50/2 of Ro 03-8799 was 0.68 mg/g body wt (mg/gbw) after intravenous (i.v.) administration, and that of SR-2508 was 4.4 mg/gbw after i.v. administration. When both drugs were given together in equitoxic proportions, the LD50/2 was 0.45 mg of Ro 03-8799 plus 2.9 mg of SR-2508/gbw. These doses are 66% of the respective LD50/2 values of the drugs when given separately. Radiosensitization was evaluated using in vivo-in vitro assays with EMT6/SF tumors in BALB/c mice. At drug doses between 10 and 60% of the LD50/2, sensitization was generally maximal and similar to that from misonidazole, but there was less sensitization below this dose, both with the drugs given separately and together. If chronic toxicities of these drugs overlap as do the acute toxicities there will be little or no additional benefit from using these drugs in combination, compared to using them separately.

  1. Juan Luis Vives: Tradition and Innovation in Renaissance Rhetoric.

    ERIC Educational Resources Information Center

    Abbott, Don Paul

    1986-01-01

    Argues that Juan Luis Vives' efforts to rehabilitate the discipline of discourse may well have been the most original of the sixteenth century, and that his discussion of elecutio (the essence of rhetoric) is considerably more distinguished than that of the better known Peter Ramus. (RS)

  2. Putting Educational Attainment First: An Interview with Juan Sepulveda

    ERIC Educational Resources Information Center

    Carreon, Joe

    2011-01-01

    This article presents an interview with Juan Sepulveda. Sepulveda was appointed by U.S. Secretary of Education Arne Duncan to the position of Executive Director of the White House Initiative on Educational Excellence for Hispanics on May 19, 2009. In this capacity, Sepulveda is responsible for directing the efforts of the White House Initiative in…

  3. Offshore finfish mariculture in the Strait of Juan de Fuca

    SciTech Connect

    Rensel, Jack; Kiefer, Dale; Forster, John R.; Woodruff, Dana L.; Evans, Nathan R.

    2007-10-07

    Finfish mariculture has existed in the U.S. Pacific Northwest for over thirty years, but for the past 15 years most effort has focused on culture of Atlantic salmon in protected, inshore cage sites. The Strait of Juan de Fuca (the "Strait") is a large area with relatively sparce shoreline development and several apparent advantages for mariculture using offshore technology.

  4. San Juan College Task Force on Innovation 1995 Report.

    ERIC Educational Resources Information Center

    Moore, Nelle

    In fall 1994, San Juan College, in New Mexico, established the Task Force on Innovation to examine changes in the paradigm of education and how those changes might affect the college. The Task Force determined that the primary driver of change in education was technology, and specifically the increasing number of means and ease of access to…

  5. Local Control and Self-Determination: The San Juan Case.

    ERIC Educational Resources Information Center

    Garman, Keats; Jack, Donald

    Rapidly increasing Navajo enrollment in San Juan County, Utah, public schools in the 1960's forced the rural school district to improve educational services to a sizable Navajo population while attempting to preserve local control in the face of changing Indian self-determination policy. The district implemented a Curriculum Development Center, a…

  6. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    ERIC Educational Resources Information Center

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in…

  7. [Psychiatric Hospital San Juan de Dios. One hundred years later].

    PubMed

    Cocula-León, Horacio

    2014-01-01

    Mental health and psychiatric diseases have always attracted people's and health authorities' attention due to its magical approach, the lack of knowledge that surrounds them, and, at the same time, the religious fear they provoke. Both have played an important role in the history of humanity, of public health politics, and of physicians. The places where psychiatric patients were treated are of historical interest, because through the historical knowledge we can identify an approach from the science and the health policies that prevailed in each age. At the beginning of the 20th century, it was developed in México a new model of hospital care attention to psychiatric patients. La Casa de Salud San Juan de Dios para Pacientes Alienados is an example; the concept "alienated patients" suggests a social and cultural perspective. This paper presents a chronological type description of one of the major institutions involved in mental health care in México. Similarly, it shows a review of the events that affected the religious order San Juan de Dios from 1901 to 2012, when the hospitaller order was reinstated in México and established the Casa de Salud San Juan de Dios para Pacientes Alienados in the town of Zapopan, Jalisco, institution that exists up to the present day and keeps participating in the mental health care in the state of Jalisco, with the current name of Servicios de Salud San Juan de Dios.

  8. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    SciTech Connect

    Jauharoh, Siti Nur Aisyah; Saegusa, Jun; Sugimoto, Takeshi; Ardianto, Bambang; Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo; Tokuno, Osamu; Nakamachi, Yuji; Kumagai, Shunichi; Kawano, Seiji

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

  9. Dispersion and nonlinear effects in OFDM-RoF system

    NASA Astrophysics Data System (ADS)

    Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

    2010-08-01

    The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

  10. Potential prodrugs of 6-acetylmethylenepenicillanic acid (Ro 15-1903).

    PubMed

    Adam, S; Then, R; Angehrn, P

    1986-06-01

    The synthesis and biological activities of a series of non-classical penicillins are described. These compounds were synthesized by treating the pivaloyloxymethyl ester of 6-acetylmethylenepenicillanic acid (Ro 15-1903) with various nucleophiles. They were found to be less active against the beta-lactamases from Proteus vulgaris 1028, Escherichia coli 1024, Klebsiella pneumoniae NCTC 418 and E. coli RTEM than the parent compound. Nevertheless, synergy with ampicillin against whole bacterial cells producing beta-lactamases was evident, although the single compounds did not exhibit antibacterial properties. With the compounds 2a and 2b, synergistic interaction with ampicillin could also be demonstrated in mice.

  11. Arsenic contamination of natural waters in San Juan and La Pampa, Argentina.

    PubMed

    O'Reilly, J; Watts, M J; Shaw, R A; Marcilla, A L; Ward, N I

    2010-12-01

    Arsenic (As) speciation in surface and groundwater from two provinces in Argentina (San Juan and La Pampa) was investigated using solid phase extraction (SPE) cartridge methodology with comparison to total arsenic concentrations. A third province, Río Negro, was used as a control to the study. Strong cation exchange (SCX) and strong anion exchange (SAX) cartridges were utilised in series for the separation and preservation of arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MA(V)) and dimethylarsinic acid (DMA(V)). Samples were collected from a range of water outlets (rivers/streams, wells, untreated domestic taps, well water treatment works) to assess the relationship between total arsenic and arsenic species, water type and water parameters (pH, conductivity and total dissolved solids, TDS). Analysis of the waters for arsenic (total and species) was performed by inductively coupled plasma mass spectrometry (ICP-MS) in collision cell mode. Total arsenic concentrations in the surface and groundwater from Encon and the San José de Jáchal region of San Juan (north-west Argentina within the Cuyo region) ranged from 9 to 357 μg l(-1) As. Groundwater from Eduardo Castex (EC) and Ingeniero Luiggi (LU) in La Pampa (central Argentina within the Chaco-Pampean Plain) ranged from 3 to 1326 μg l(-1) As. The pH range for the provinces of San Juan (7.2-9.7) and La Pampa (7.0-9.9) are in agreement with other published literature. The highest total arsenic concentrations were found in La Pampa well waters (both rural farms and pre-treated urban sources), particularly where there was high pH (typically > 8.2), conductivity (>2,600 μS cm(-1)) and TDS (>1,400 mg l(-1)). Reverse osmosis (RO) treatment of well waters in La Pampa for domestic drinking water in EC and LU significantly reduced total arsenic concentrations from a range of 216-224 μg l(-1) As to 0.3-0.8 μg l(-1) As. Arsenic species for both provinces were predominantly As(III) and As(V). As

  12. The San Juan Delta, Colombia: tides, circulations, and salt dispersion

    NASA Astrophysics Data System (ADS)

    Restrepo, Juan D.; Kjerfve, Björn

    2002-05-01

    The San Juan River delta (Colombia) with an area of 800 km 2 is the largest delta environment on the Pacific coast of South America. It consists of active distributaries maintained by an average discharge of 2500 m 3 s -1, is tide dominated, and has relatively narrow estuarine mixing zones <17 km wide and typically ˜7 km wide. Water level and current time series in two distributary mouths indicate that the tide is semidiurnal with a form number 0.1-0.2 and a mean range of 3 m. Processes at tidal frequencies explain 75-95% of the water level variability with the remaining low-frequency variability attributed to meteorological forcing and river processes. The tidal phase for the main diurnal and semidiurnal constituents progress from north to south along the coast. Only the southernmost distributary experiences significant tidal asymmetry as a result of strong river discharge and shallow depths. In the northernmost distributary, shallow water constituents are insignificant. Tidal currents were more semidiurnal than the water level, with form number 0.09-0.13. Tidal ellipses indicated that currents were aligned with the channels and mean amplitudes <1 m s -1. In the delta distributaries, circulation modes varied from seaward flow at all depths during intermediate runoff conditions to gravitational circulation during rising and high discharge periods. In San Juan and Chavica distributaries, the currents were ebb-directed, while in Charambirá they were flood-directed. The circulation appears to be controlled by the morphology of the distributaries, which were weakly stratified and only sometimes moderately stratified. The net salt transport was directed seaward in San Juan and Charambirá, and landward at Chavica, indicating an imbalance in the salt budget, and signifying non-steady state behavior. The net longitudinal salt flux in the San Juan delta is largely a balance between ebb-directed advective flux, and flood-directed tidal sloshing. Along the distributary

  13. Conversion of tunneled hemodialysis catheter into HeRO device can provide immediate access for hemodialysis.

    PubMed

    Vasquez, Julio C; DeLaRosa, Jacob; Rahim, Fahim; Rahim, Naeem

    2010-11-01

    Patients with central venous occlusion who are ''tunneled catheter dependent'' are a challenge for hemodialysis access. A relatively new option for them is the hemodialysis reliable outflow (HeRO) device that can be totally implanted subcutaneously. However, patients still require a tunneled hemodialysis catheter that is used until the HeRO device is mature, 4 to 6 weeks later. Here, we describe a conversion of an existing tunneled hemodialysis catheter into a HeRO device, which was combined with a ''self-sealing'' Flixene graft. This allowed almost immediate use of the HeRO device without the need for placement of a catheter.

  14. Removal of organic contaminants by RO and NF membranes

    NASA Technical Reports Server (NTRS)

    Yoon, Yeomin; Lueptow, Richard M.

    2005-01-01

    Rejection characteristics of organic and inorganic compounds were examined for six reverse osmosis (RO) membranes and two nanofiltration (NF) membranes that are commercially available. A batch stirred-cell was employed to determine the membrane flux and the solute rejection for solutions at various concentrations and different pH conditions. The results show that for ionic solutes the degree of separation is influenced mainly by electrostatic exclusion, while for organic solutes the removal depends mainly upon the solute radius and molecular structure. In order to provide a better understanding of rejection mechanisms for the RO and NF membranes, the ratio of solute radius (r(i,s)) to effective membrane pore radius (r(p)) was employed to compare rejections. An empirical relation for the dependence of the rejection of organic compounds on the ratio r(i,s)/r(p) is presented. The rejection for organic compounds is over 75% when r(i,s)/r(p) is greater than 0.8. In addition, the rejection of organic compounds is examined using the extended Nernst-Planck equation coupled with a steric hindrance model. The transport of organic solutes is controlled mainly by diffusion for the compounds that have a high r(i,s)/r(p) ratio, while convection is dominant for compounds that have a small r(i,s)/r(p) ratio. c2005 Elsevier B.V. All rights reserved.

  15. Juan Gabriel and audience interpretation. cultural impressions of effeminacy and sexuality in Mexico.

    PubMed

    Sowards, S K

    2000-01-01

    Juan Gabriel's purported effeminacy and sexuality have made him a controversial subject in Mexico, but still loved by fans. Juan Gabriel, by trying to gain acceptance into Mexican society, has become part of a hybrid culture, between the feminine/masculine and homosexual/bisexual/heterosexual groups. This study focuses on interviews with 20 participants who discuss Juan Gabriel's popularity and sexuality. The findings of the study indicate that Juan Gabriel may be considered by his fans to be effeminate, and consequently homosexual. Even though homophobia is widespread in Mexico, Juan Gabriel's fans tend to ignore or exoticize his sexuality, thus affording his success. It is also possible that Juan Gabriel, consciously or not, uses his controversial sexuality as a way to generate popular interest.

  16. CoRoT 101186644: A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H. J.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

    2013-05-01

    We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (mV = 16) candidate revealed an eclipsing binary composed of a late F-type primary (Teff = 6090 ± 200 K) and a low-mass, dense late M-dwarf secondary on an eccentric (e = 0.4) orbit with a period of ~20.7 days. The M-dwarf has a mass of 0.096 ± 0.011 M⊙, and a radius of 0.104-0.006+0.026 R⊙, which possibly makes it the smallest and densest late M-dwarf reported so far. Unlike the claim that theoretical models predict radii that are 5-15% smaller than measured for low-mass stars, this one seems to have a radius that is consistent and might even be below the radius predicted by theoretical models. Based on observations made with the 1-m telescope at the Wise Observatory, Israel, the Swiss 1.2-m Leonhard Euler telescope at La Silla Observatory, Chile, the IAC-80 telescope at the Observatory del Teide, Canarias, Spain, and the 3.6-m telescope at La Silla Observatory (ESO), Chile (program 184.C-0639).

  17. Oral anatomy in the sixteenth century: Juan Valverde de Amusco.

    PubMed

    López-Valverde, A; Gómez de Diego, R; De Vicente, J

    2013-08-01

    In 1554 Juan Valverde de Amusco, a Spanish anatomist, wrote the History of the composition of the human body, a complete anatomical treatise that took as its model the Vesalius school of thought (La fábrica of Vesalius). Considered one of the most complete anatomical treatises of the Renaissance and one of the most widely read books of the sixteenth century, it was translated into four languages in its day. The first chapter, devoted to bones, provides a meticulously detailed analysis of the bones of the facial structures and of the teeth, their supporting structures, vascularisation and innervation. Juan Valverde de Amusco even describes techniques for reducing mandibular luxations. Even with the imprecise observations typical of the time the treatise must be considered an exceptional document.

  18. Mineralogy from Cores in Prospect Gulch, San Juan County, Colorado

    USGS Publications Warehouse

    Bove, Dana J.; Johnson, Raymond H.; Yager, Douglas B.

    2007-01-01

    In the late nineteenth century, San Juan County, Colorado, was the center of a metal mining boom in the San Juan Mountains. Although most mining activity ceased by the 1990s, the effects of historical mining continue to contribute metals to ground water and surface water. Previous research by the U.S. Geological Survey identified ground-water discharge as a significant pathway for the loading of metals to surface water from both acid-mine drainage and acid-rock drainage. In an effort to understand the ground-water flow system in the upper Animas River watershed, Prospect Gulch was selected for further study because of the amount of previous data provided in and around that particular watershed. In support of this ground-water research effort, data was collected from drill core, which included: (1) detailed descriptions of the subsurface geology and hydrothermal alteration patterns, (2) depth of sulfide oxidation, and (3) quantitative mineralogy.

  19. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward...

  20. Teaching and Communicating Astronomy at Rey Juan Carlos University

    NASA Astrophysics Data System (ADS)

    Hernán-Obispo, M.; Serrano, A.; Aguirre, J.; Martín, P. San

    We present our activities of popularization of Astronomy at Rey Juan Carlos University in Madrid, especially our 30-h workshop for people older than 55 (University for the Elderly) held since the academic year 2002/2003. Our course aims to introduce the basic topics on Astronomy to a group of motivated students who, in most cases, were not able to complete their education in their youth due to the historical environment of Spain in the middle of the twentieth century.

  1. Gas-Phase Ozonolysis of Cycloalkenes: Formation of Highly Oxidized RO2 Radicals and Their Reactions with NO, NO2, SO2, and Other RO2 Radicals.

    PubMed

    Berndt, Torsten; Richters, Stefanie; Kaethner, Ralf; Voigtländer, Jens; Stratmann, Frank; Sipilä, Mikko; Kulmala, Markku; Herrmann, Hartmut

    2015-10-15

    The gas-phase reaction of ozone with C5-C8 cycloalkenes has been investigated in a free-jet flow system at atmospheric pressure and a temperature of 297 ± 1 K. Highly oxidized RO2 radicals bearing at least 5 O atoms in the molecule and their subsequent reaction products were detected in most cases by means of nitrate-CI-APi-TOF mass spectrometry. Starting from a Criegee intermediate after splitting-off an OH-radical, the formation of these RO2 radicals can be explained via an autoxidation mechanism, meaning RO2 isomerization (ROO → QOOH) and subsequently O2 addition (QOOH + O2 → R'OO). Time-dependent RO2 radical measurements concerning the ozonolysis of cyclohexene indicate rate coefficients of the intramolecular H-shifts, ROO → QOOH, higher than 1 s(-1). The total molar yield of highly oxidized products (predominantly RO2 radicals) from C5-C8 cycloalkenes in air is 4.8-6.0% affected with a calibration uncertainty by a factor of about two. For the most abundant RO2 radical from cyclohexene ozonolysis, O,O-C6H7(OOH)2O2 ("O,O" stands for two O atoms arising from the ozone attack), the determination of the rate coefficients of the reaction with NO2, NO, and SO2 yielded (1.6 ± 0.5) × 10(-12), (3.4 ± 0.9) × 10(-11), and <10(-14) cm(3) molecule(-1) s(-1), respectively. The reaction of highly oxidized RO2 radicals with other peroxy radicals (R'O2) leads to detectable accretion products, RO2 + R'O2 → ROOR' + O2, which allows to acquire information on peroxy radicals not directly measurable with the nitrate ionization technique applied here. Additional experiments using acetate as the charger ion confirm conclusively the existence of highly oxidized RO2 radicals and closed-shell products. Other reaction products, detectable with this ionization technique, give a deeper insight in the reaction mechanism of cyclohexene ozonolysis.

  2. San Juan sag: A newly discovered basin beneath San Juan volcanic field of south-central Colorado

    SciTech Connect

    Gries, R.R.

    1989-09-01

    The San Juan sag is a Laramide foreland basin formerly adjacent to and west of the Laramide northern Sangre de Cristo/San Luis highland. Wrench faulting (Eocene ) and rifting (Oligocene and Miocene) split this bounding uplift and formed the San Luis basin adjacent to and east of the sag. Volcanism concealed the San Juan sag with over 10,000 ft of intermediate volcanic deposits, and its presence remained in doubt until oil in the volcanic rocks encouraged exploration for the underlying sedimentary rocks. Drilling through the volcanic field since 1984 has revealed the presence of Paleocene and Eocene( ) clastic sediments, the Cretaceous Lewis, Mancos, and Dakota formations, and the Jurassic Morrison and Junction Creek formations. Additionally, oil and gas shows abound, and minor production has been established. Exploratory drilling and geophysical acquisitions have helped to define basin geometry, reservoir rocks, source rocks, and maturation and burial history.

  3. In vitro activity of RO363, a beta1-adrenoceptor selective agonist.

    PubMed Central

    Iakovidis, D.; Malta, E.; McPherson, G. A.; Raper, C.

    1980-01-01

    1 The beta-adrenoceptor stimulant effects of RO363 and (--)-isoprenaline have been compared in a variety of isolated tissue preparations. 2 RO363 is approximately half as potent as (--)-isoprenaline in tissues where actions are due to beta1-receptor activation (guinea-pig atrial and ileal preparations and ventricular strips from the rabbit, rat and guinea-pig. 3 In uterine and lung strip preparations from the guinea-pig, where responses are due to beta2-receptor stimulation. RO363 is 100 to 350 times less active than (--)-isoprenaline and has a low intrinsic activity. 4 In spontaneously contracted tracheal preparations from the guinea-pig, RO363 is a full agonist and is approximately half as potent as (--)-isoprenaline. These effects of RO363 are due to the activation of a population of beta1-receptors in the tissue since RO363 and (--)-isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations. In addition the Kb values for practolol are similar in all these preparations when RO363 is used as the agonist. 5 The results show that RO363 is a potent and highly selective beta1-receptor agonist. PMID:6103722

  4. Emerging roles for the Ro 60 kDa autoantigen in noncoding RNA metabolism

    PubMed Central

    Sim, Soyeong; Wolin, Sandra L.

    2011-01-01

    All cells contain an enormous variety of ribonucleoprotein complexes that function in diverse processes. Although the mechanisms by which many of these RNPs contribute to cell metabolism are well understood, the roles of others are only now beginning to be revealed. A member of this latter category, the Ro 60 kDa protein and its associated noncoding Y RNAs, was discovered because the protein component is a frequent target of the autoimmune response in patients with the rheumatic diseases systemic lupus erythematosus and Sjögren’s syndrome. Recent studies have shown that Ro is ring-shaped, binds the single-stranded ends of misfolded noncoding RNAs in its central cavity, and may function in noncoding RNA quality control. Although Ro is not present in yeast, many bacterial genomes contain potential Ro orthologs. In the radiation-resistant eubacterium Deinococcus radiodurans, the Ro ortholog functions with exoribonucleases during stress-induced changes in RNA metabolism. Moreover, in both D. radiodurans and animal cells, Ro is involved in the response to multiple types of environmental stress. Finally, Y RNAs can influence the subcellular location of Ro, inhibit access of the central cavity to other RNAs and may also act as binding sites for proteins that influence Ro function. PMID:21823229

  5. TU-CD-BRD-00: Incident Learning / RO-ILS

    SciTech Connect

    2015-06-15

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

  6. High Flux, Fouling Resistant Membranes for RO Pretreatment

    DTIC Science & Technology

    2010-07-30

    hollow-fiber, ultrafiltration membrane. Activities in the second 3 months of the project included: 1. completing the set up of production and lab...develop a fouling resistant, hollow‐fiber,  ultrafiltration  membrane.  Activities in the second 3 months of the project included:  1. completing the set up...of the RO.  However, current commercial  ultrafiltration  and microfiltration  membranes used for RO pre‐treatment are inadequate and subject to fouling

  7. Hydrologic data from wells at or in the vicinity of the San Juan coal mine, San Juan County, New Mexico

    USGS Publications Warehouse

    Stewart, Anne M.; Thomas, Nicole

    2015-01-01

    In 2010, in cooperation with the Mining and Minerals Division (MMD) of the State of New Mexico Energy, Minerals and Natural Resources Department, the U.S. Geological Survey (USGS) initiated a 4-year assessment of hydrologic conditions at the San Juan coal mine (SJCM), located about 14 miles west-northwest of the city of Farmington, San Juan County, New Mexico. The mine produces coal for power generation at the adjacent San Juan Generating Station (SJGS) and stores coal-combustion byproducts from the SJGS in mined-out surface-mining pits. The purpose of the hydrologic assessment is to identify groundwater flow paths away from SJCM coal-combustion-byproduct storage sites that might allow metals that may be leached from coal-combustion byproducts to eventually reach wells or streams after regional dewatering ceases and groundwater recovers to predevelopment levels. The hydrologic assessment, undertaken between 2010 and 2013, included compilation of existing data. The purpose of this report is to present data that were acquired and compiled by the USGS for the SJCM hydrologic assessment.

  8. VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT 2016)

    NASA Astrophysics Data System (ADS)

    COROT Team

    2014-03-01

    CoRoT, a space astronomy mission, has measured photometric micro-variability of stars from minutes to months (up to 150 days) with a high duty cycle (more than 90%). The mission was led by CNES in association with four French laboratories and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite was composed of a PROTEUS platform (the 3rd in the series) and a unique instrument: a stellar rapid photometer. It was launched on December 27th 2006 by a Soyuz Rocket, from Bakonour. The mission has lasted almost 6 years (the nominal 3-year duration and a 3-year extension) and has observed more than 160 000 stars. It stopped sending data on November 2nd 2012. Two regions of the sky were accessible for long period of time: circles of 10 degrees centered on the equator around alpha=06:50 and alpha=18:50. They were called the CoRoT eyes: the "anticenter" and the "center eye" (as they are approximately in these directions). Each pointing covers 1.4x2.8 square degrees within one of those CoRoT eyes. The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transiting in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The "bright star" mode dedicated to very precise seismology of a small sample of bright and closeby stars - The "faint star" mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer. The large amount of data gathered in this mode turned out to be extremely fruitful for many topics of stellar physics. Beyond these two initial objectives, CoRoT data revealed stellar variability associated with various other phenomena: granulation, rotational modulation

  9. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  10. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  11. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  12. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  13. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  14. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  15. 33 CFR 167.1302 - In the approaches to the Strait of Juan de Fuca: Southwestern approach.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Southwestern approach. 167.1302 Section 167.1302 Navigation and Navigable Waters....1302 In the approaches to the Strait of Juan de Fuca: Southwestern approach. In the southwestern approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by...

  16. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  17. 33 CFR 167.1301 - In the approaches to the Strait of Juan de Fuca: Western approach.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Western approach. 167.1301 Section 167.1301 Navigation and Navigable Waters COAST....1301 In the approaches to the Strait of Juan de Fuca: Western approach. In the western approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by a line...

  18. 33 CFR 167.1302 - In the approaches to the Strait of Juan de Fuca: Southwestern approach.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Southwestern approach. 167.1302 Section 167.1302 Navigation and Navigable Waters....1302 In the approaches to the Strait of Juan de Fuca: Southwestern approach. In the southwestern approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by...

  19. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  20. 33 CFR 167.1301 - In the approaches to the Strait of Juan de Fuca: Western approach.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Western approach. 167.1301 Section 167.1301 Navigation and Navigable Waters COAST....1301 In the approaches to the Strait of Juan de Fuca: Western approach. In the western approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by a line...

  1. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  2. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  3. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  4. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  5. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  6. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY.

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  7. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  8. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  9. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  10. 78 FR 61958 - San Juan County Historical Society; Notice of Preliminary Determination of A Qualifying Conduit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-08

    ... Energy Regulatory Commission San Juan County Historical Society; Notice of Preliminary Determination of A..., San Juan County Historical Society filed a notice of intent to construct a qualifying conduit... Historical Society, P.O. Box 154, Silverton, CO 81433, Phone No. (970) 387-5488. FERC Contact: Robert...

  11. Pole of rotating analysis of present-day Juan de Fuca plate motion

    NASA Technical Reports Server (NTRS)

    Nishimura, C.; Wilson, D. S.; Hey, R. N.

    1984-01-01

    Convergence rates between the Juan de Fuca and North American plates are calculated by means of their relative, present-day pole of rotation. A method of calculating the propagation of errors in addition to the instantaneous poles of rotation is also formulated and applied to determine the Euler pole for Pacific-Juan de Fuca. This pole is vectorially added to previously published poles for North America-Pacific and 'hot spot'-Pacific to obtain North America-Juan de Fuca and 'hot spot'-Juan de Fuca, respectively. The errors associated with these resultant poles are determined by propagating the errors of the two summed angular velocity vectors. Under the assumption that hot spots are fixed with respect to a mantle reference frame, the average absolute velocity of the Juan de Puca plate is computed at approximately 15 mm/yr, thereby making it the slowest-moving of the oceanic plates.

  12. Tectonics and evolution of the Juan Fernandez microplate at the Pacific-Nazca-Antarctic triple junction

    NASA Technical Reports Server (NTRS)

    Anderson-Fontana, S.; Larson, R. L.; Engein, J. F.; Lundgren, P.; Stein, S.

    1986-01-01

    Magnetic and bathymetric profiles derived from the R/V Endeavor survey and focal mechanism studies for earthquakes on two of the Juan Fernandez microplate boundaries are analyzed. It is observed that the Nazca-Juan Fernandez pole is in the northern end of the microplate since the magnetic lineation along the East Ridge of the microplate fans to the south. The calculation of the relative motion of the Juan Fernandez-Pacific-Nazca-Antarctic four-plate system using the algorithm of Minster et al. (1974) is described. The development of tectonic and evolutionary models of the region is examined. The tectonic model reveals that the northern boundary of the Juan Fernandez microplate is a zone of compression and that the West Ridge and southwestern boundary are spreading obliquely; the evolutionary model relates the formation of the Juan Fernandez microplate to differential spreading rates at the triple junction.

  13. Rapid field assessment of RO desalination of brackish agricultural drainage water.

    PubMed

    Thompson, John; Rahardianto, Anditya; Gu, Han; Uchymiak, Michal; Bartman, Alex; Hedrick, Marcos; Lara, David; Cooper, Jim; Faria, Jose; Christofides, Panagiotis D; Cohen, Yoram

    2013-05-15

    Rapid field evaluation of RO feed filtration requirements, selection of effective antiscalant type and dose, and estimation of suitable scale-free RO recovery level were demonstrated using a novel approach based on direct observation of mineral scaling and flux decline measurements, utilizing an automated Membrane Monitor (MeMo). The MeMo, operated in a stand-alone single-pass desalting mode, enabled rapid assessment of the adequacy of feed filtration by enabling direct observation of particulate deposition on the membrane surface. The diagnostic field study with RO feed water of high mineral scaling propensity revealed (via direct MeMo observation) that suspended particulates (even for feed water of turbidity <1 NTU) could serve as seeds for promoting surface crystal nucleation. With feed filtration optimized, a suitable maximum RO water recovery, with complete mineral scale suppression facilitated by an effective antiscalant dose, can be systematically and directly identified (via MeMo) in the field for a given feed water quality. Scale-free operating conditions, determined via standalone MeMo rapid diagnostic tests, were shown to be applicable to spiral-would RO system as validated via both flux decline measurements and ex-situ RO plant membrane scale monitoring. It was shown that the present approach is suitable for rapid field assessment of RO operability and it is particularly advantageous when evaluating water sources of composition that may vary both temporally and across the regions of interest.

  14. WARM SPITZER PHOTOMETRY OF THE TRANSITING EXOPLANETS CoRoT-1 AND CoRoT-2 AT SECONDARY ECLIPSE

    SciTech Connect

    Deming, Drake; Knutson, Heather; Agol, Eric; Cowan, Nicolas B.; Desert, Jean-Michel; Charbonneau, David; Burrows, Adam; Fortney, Jonathan J.; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2011-01-10

    We measure secondary eclipses of the hot giant exoplanets CoRoT-1 at 3.6 and 4.5 {mu}m, and CoRoT-2 at 3.6 {mu}m, both using Warm Spitzer. We find that the Warm Spitzer mission is working very well for exoplanet science. For consistency of our analysis we also re-analyze archival cryogenic Spitzer data for secondary eclipses of CoRoT-2 at 4.5 and 8 {mu}m. We compare the total data for both planets, including optical eclipse measurements by the CoRoT mission, and ground-based eclipse measurements at 2 {mu}m, to existing models. Both planets exhibit stronger eclipses at 4.5 than at 3.6 {mu}m, which is often indicative of an atmospheric temperature inversion. The spectrum of CoRoT-1 is best reproduced by a 2460 K blackbody, due either to a high altitude layer that strongly absorbs stellar irradiance, or an isothermal region in the planetary atmosphere. The spectrum of CoRoT-2 is unusual because the 8 {mu}m contrast is anomalously low. Non-inverted atmospheres could potentially produce the CoRoT-2 spectrum if the planet exhibits line emission from CO at 4.5 {mu}m, caused by tidal-induced mass loss. However, the viability of that hypothesis is questionable because the emitting region cannot be more than about 30% larger than the planet's transit radius, based on the ingress and egress times at eclipse. An alternative possibility to account for the spectrum of CoRoT-2 is an additional opacity source that acts strongly at wavelengths less than 5 {mu}m, heating the upper atmosphere while allowing the deeper atmosphere seen at 8 {mu}m to remain cooler. We obtain a similar result as Gillon et al. for the phase of the secondary eclipse of CoRoT-2, implying an eccentric orbit with e cos({omega}) = -0.0030 {+-} 0.0004.

  15. Mediastinal pathology and the contributions of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst. This review recounts his role as one of the principal figures in the surgical pathology of mediastinal diseases.

  16. Sr isotopic variations along the Juan de Fuca Ridge.

    USGS Publications Warehouse

    Eaby, J.; Clague, D.A.; Delaney, J.R.

    1984-01-01

    The Sr isotopic ratios of 39 glass and microcrystalline basalt samples along the Juan de Fuca Ridge and one glass sample from Brown Bear Seamount are at the lower end of the range for normal MORB; the average 87Sr/86Sr ratio is 0.70249 + or - 0.00014 (2sigma ). Although subtle variations exist along the strike of the ridge, the Sr isotopic data do not show systematic variation relative to the proposed Cobb hotspot. The isotopic data are inconsistent with an enriched mantle-plume origin for the Cobb-Eikelberg Seamount chain.-W.H.B.

  17. Gibberellins regulate the transcription of the continuous flowering regulator, RoKSN, a rose TFL1 homologue

    PubMed Central

    Foucher, Fabrice

    2012-01-01

    The role of gibberellins (GAs) during floral induction has been widely studied in the annual plant Arabidopsis thaliana. Less is known about this control in perennials. It is thought that GA is a major regulator of flowering in rose. In spring, low GA content may be necessary for floral initiation. GA inhibited flowering in once-flowering roses, whereas GA did not block blooming in continuous-flowering roses. Recently, RoKSN, a homologue of TFL1, was shown to control continuous flowering. The loss of RoKSN function led to continuous flowering behaviour. The objective of this study was to understand the molecular control of flowering by GA and the involvement of RoKSN in this inhibition. In once-flowering rose, the exogenous application of GA3 in spring inhibited floral initiation. Application of GA3 during a short period of 1 month, corresponding to the floral transition, was sufficient to inhibit flowering. At the molecular level, RoKSN transcripts were accumulated after GA3 treatment. In spring, this accumulation is correlated with floral inhibition. Other floral genes such as RoFT, RoSOC1, and RoAP1 were repressed in a RoKSN-dependent pathway, whereas RoLFY and RoFD repression was RoKSN independent. The RoKSN promoter contained GA-responsive cis-elements, whose deletion suppressed the response to GA in a heterologous system. In summer, once-flowering roses did not flower even after exogenous application of a GA synthesis inhibitor that failed to repress RoKSN. A model is presented for the GA inhibition of flowering in spring mediated by the induction of RoKSN. In summer, factors other than GA may control RoKSN. PMID:23175671

  18. Ceftriaxone (Ro 13-9904) therapy of serious infection.

    PubMed Central

    Bradsher, R W

    1982-01-01

    Ceftriaxone (Ro 13-9904), a newly developed cephalosporin with a long half-life, was evaluated for efficacy and safety in 19 patients with serious infections. Underlying illnesses were present in 16 patients. Ceftriaxone was given intravenously every 12 h. Infections treated included gram-negative bacillary pneumonias (two cases), staphylococcal and streptococcal soft tissue-skeletal infections (six cases), spontaneous peritonitis (two cases), and complicated urinary tract infections (nine cases). Bacteremia was present in three patients. Microbiological and clinical cures were achieved in all but one case, although three patients with urinary infection had recurrences 6 weeks posttherapy. The only failure occurred in a patient with pneumonia who had a Pseudomonas aeruginosa isolated from sputum with an initial minimal inhibitory concentration of 4 micrograms/ml, but after 9 days of therapy, a repeat isolate had a minimal inhibitory concentration of 32 micrograms/ml. The minimal inhibitory concentrations for the other isolates ranged from less than or equal to 0.6 to 8.0 micrograms/ml. The mean peak plasma level of ceftriaxone was 99.9 micrograms/ml. The only side effects noted were drug fever in one patient, phlebitis in two patients, and thrombocytosis in four patients. PMID:6289739

  19. Liquefaction during the 1977 San Juan Province, Argentina earthquake (Ms = 7.4)

    USGS Publications Warehouse

    Youd, T.L.; Keefer, D.K.

    1994-01-01

    Liquefaction effects generated by the 1977 San Juan Province, Argentina, earthquake (Ms = 7.4) are described. The larger and more abundant effects were concentrated in the 60-km long band of the lowlands in the Valle del Bermejo and in an equally long band along the Rio San Juan in the Valle de Tulum. Fissures in the Valle del Bermejo were up to several hundred meters long and up to several meters wide. Sand deposits, from boils that erupted through the fissures, covered areas up to tens of square meters. Fissures generally parallelled nearby stream channels. Because the Valle del Bermejo is undeveloped, these large features caused no damage. Liquefaction in the Valle del Tulum caused important or unusual damage at several localities, including the following five sites: (1) At the Barrio Justo P. Castro, a subdivision of Caucete, liquefaction of subsurface sediments decoupled overlying, unliquefied stiff sediments, producing a form of ground failure called "ground oscillation". The associated differential ground movements pulled apart houses and pavements in extension, while shearing curbs and buckling canal linings in compression at the same locality. (2) At the Escuela Normal, in Caucete, the roof of a 30-m long single-story classroom building shifted westward relative to the foundation. That displacement fractured and tilted columns supporting the roof. The foundation was fractured at several places, leaving open cracks, as wide as 15 mm. The cumulative width of the open cracks was 48 mm, an amount roughly equivalent to the 63 mm of offset between the roof and foundation at the east end of the building. The ground and foundation beneath the building extended (or spread) laterally opening cracks and lengthening the foundation while the roof remained in place. (3) The most spectacular damage to structures at the community of San Martin was the tilting of a 6-m high water tower and the toppling of a nearby pump house into a 1-m deep crater. Similarly, a small

  20. The Fate of the Juan de Fuca Plate

    NASA Astrophysics Data System (ADS)

    Xue, M.; Allen, R. M.

    2006-12-01

    The Juan de Fuca plate is subducting beneath the northwestern United States and southwestern Canada. Although the slab has been imaged to depths of at least ~{400} km beneath Washington and at least ~{200} to 300 km beneath northern Oregon with a dip of ~60° to the east, there is little evidence for a slab east of High Cascades deeper than ~150 km beneath central and ~200 km beneath southern Oregon. To image the slab beneath Oregon, we apply tomography technique using a dataset consisting of our own OATS deployment and all other available data. For the Vs inversion, a total of 95 events with clear S and SKS phases were recorded at 45 stations and a total number of 2148 rays were used. For the Vp inversion, a total of 74 events with clear direct P phase were recorded at 46 stations, and a total number of 2043 rays were used. Our tomographic images clearly show that the Juan de Fuca plate dives into the mantle beneath Oregon and continues east of the High Cascades with a dip of ~50° reaching a depth of ~400 km. The slab does not dip more vertically than its counterparts to north and south, which have a dip of ~60° and ~65° respectively. Resolution tests suggest there is little or no velocity anomaly associated with a slab below ~400 km.

  1. Transiting exoplanets from the CoRoT space mission. VII. The ``hot-Jupiter''-type planet CoRoT-5b

    NASA Astrophysics Data System (ADS)

    Rauer, H.; Queloz, D.; Csizmadia, Sz.; Deleuil, M.; Alonso, R.; Aigrain, S.; Almenara, J. M.; Auvergne, M.; Baglin, A.; Barge, P.; Bordé, P.; Bouchy, F.; Bruntt, H.; Cabrera, J.; Carone, L.; Carpano, S.; de La Reza, R.; Deeg, H. J.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guillot, T.; Guenther, E.; Hatzes, A.; Hébrard, G.; Kabath, P.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Rabus, M.; Renner, S.; Rouan, D.; Shporer, A.; Samuel, B.; Schneider, J.; Triaud, A. H. M. J.; Wuchterl, G.

    2009-10-01

    Aims: The CoRoT space mission continues to photometrically monitor about 12 000 stars in its field-of-view for a series of target fields to search for transiting extrasolar planets ever since 2007. Deep transit signals can be detected quickly in the “alarm-mode” in parallel to the ongoing target field monitoring. CoRoT's first planets have been detected in this mode. Methods: The CoRoT raw lightcurves are filtered for orbital residuals, outliers, and low-frequency stellar signals. The phase folded lightcurve is used to fit the transit signal and derive the main planetary parameters. Radial velocity follow-up observations were initiated to secure the detection and to derive the planet mass. Results: We report the detection of CoRoT-5b, detected during observations of the LRa01 field, the first long-duration field in the galactic anti-center direction. CoRoT-5b is a “hot Jupiter-type” planet with a radius of 1.388+0.046-0.047 R_Jup, a mass of 0.467+0.047-0.024 M_Jup, and therefore, a mean density of 0.217+0.031-0.025 g cm-3. The planet orbits an F9V star of 14.0 mag in 4.0378962 ± 0.0000019 days at an orbital distance of 0.04947+0.00026-0.00029 AU. Observations made with SOPHIE spectrograph at the Observatoire de Haute Provence (07B.PNP.MOUT), France, and HARPS spectrograph at ESO La Silla Observatory (072.C-0488(E), 082.C-0312(A)), and partly based on observations made at the Anglo-Australian Telescope. The CoRoT space mission, launched on December 27, 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.

  2. Roll-On/Roll-Off (RO/RO) Discharge Facility Tests with MV CYGNUS and SS ATLANTIC BEAR (COTS CNO Project 299, DT-IIF-1).

    DTIC Science & Technology

    1983-11-01

    AD-R139 346 ROLL-ON/ROLL-OFF (RO/RO) DISCHARGE FACILITY TESTS NITH 1/1 MY CYGNUS AND SS A..(U) DAVID N TAYLOR NAVAL SHIP RESEARCH AND DEVELOPMENT...MICROCOPY RESOLUTION TEST CHART NATIONA. DUEAU OF STANOAD$S-1963-A •-’ ,jh DAVID W. TAYLOR NAVAL SHIP RMSEARCH AND DEVELOPMENT CENTER ROLL-ON/ROLL...by the David W. Taylor Naval Ship Research and Development Center (DTNSRDC), Mobile Support Systems Office, Code 1190, Task Area Y0816.002 and Work

  3. Transiting exoplanets from the CoRoT space mission. XXV. CoRoT-27b: a massive and dense planet on a short-period orbit

    NASA Astrophysics Data System (ADS)

    Parviainen, H.; Gandolfi, D.; Deleuil, M.; Moutou, C.; Deeg, H. J.; Ferraz-Mello, S.; Samuel, B.; Csizmadia, Sz.; Pasternacki, T.; Wuchterl, G.; Havel, M.; Fridlund, M.; Angus, R.; Tingley, B.; Grziwa, S.; Korth, J.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Baglin, A.; Barros, S. C. C.; Bordé, P.; Bouchy, F.; Cabrera, J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Guillot, T.; Hatzes, A.; Hébrard, G.; Mazeh, T.; Montagnier, G.; Ofir, A.; Ollivier, M.; Pätzold, M.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.

    2014-02-01

    Aims: We report the discovery of a massive and dense transiting planet CoRoT-27b on a 3.58-day orbit around a 4.2 Gyr-old G2 star. The planet candidate was identified from the CoRoT photometry, and was confirmed as a planet with ground-based spectroscopy. Methods: The confirmation of the planet candidate is based on radial velocity observations combined with imaging to rule out blends. The characterisation of the planet and its host star was carried out using a Bayesian approach where all the data (CoRoT photometry, radial velocities, and spectroscopic characterisation of the star) are used jointly. The Bayesian analysis included a study whether the assumption of white normally distributed noise holds for the CoRoT photometry and whether the use of a non-normal noise distribution offers advantages in parameter estimation and model selection. Results: CoRoT-27b has a mass of 10.39 ± 0.55MJup, a radius of 1.01 ± 0.04RJup, a mean density of 12.6-1.67+1.92g cm-3, and an effective temperature of 1500 ± 130 K. The planet orbits around its host star, a 4.2 Gyr-old G2-star with a mass M⋆ = 1.06M⊙ and a radius R⋆ = 1.05R⊙, on a 0.048 ± 0.007 AU orbit of 3.58 days. The radial velocity observations allow us to exclude highly eccentric orbits, namely, e < 0.065 with 99% confidence. Given its high mass and density, theoretical modelling of CoRoT-27b is demanding. We identify two solutions with heavy element mass fractions of 0.11 ± 0.08M⊕ and 0.07 ± 0.06M⊕, but even solutions void of heavy elements cannot be excluded. We carry out a secondary eclipse search from the CoRoT photometry using a method based on Bayesian model selection, but conclude that the noise level is too high to detect eclipses shallower than 9% of the transit depth. Using a non-normal noise model was shown not to affect the parameter estimation results, but led to significant improvement in the sensitivity of the model selection process. The CoRoT space mission, launched on December 27, 2006

  4. Quality of life in functional rhinoplasty: rhinoplasty outcomes evaluation German version (ROE-D).

    PubMed

    Bulut, Olcay Cem; Plinkert, Peter K; Wallner, Frank; Baumann, Ingo

    2016-09-01

    The aim of this study was to validate a German version of the rhinoplasty outcomes evaluation (ROE) questionnaire. A prospective study was conducted and a German translated ROE (ROE-D) questionnaire administered to 100 patients preoperatively, 6 and 12 months postoperatively. The translation was performed according to internationally accepted guidelines. To validate this instrument, we evaluated its reliability, validity and sensitivity. ROE-D was completed by 54 patients after 6 months and by 69 patients 1 year after functional rhinoplasty. Cronbach's α indicated good internal consistency. Reliability was tested with a split-half-reliability, showing significant correlation. Discrimination validity was demonstrated by a comparison with healthy controls. Sensitivity to change showed medium to large effects. ROE-D is a reliable, validated and sensitive German instrument for measuring health-related quality of life in patients after rhinoplasty. The ROE-D focuses mainly on the aesthetic aspects of the rhinoplasty surgery.

  5. Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis

    PubMed Central

    2012-01-01

    Introduction Autoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood. We undertook this study to determine the clinical and serologic associations of anti-Ro52/TRIM21 antibodies in patients with systemic sclerosis (SSc). Methods Detailed clinical data and sera from 963 patients with SSc enrolled in a multicenter cohort study were collected and entered into a central database. Antibodies to Ro52/TRIM21 and other autoantibodies were detected with an addressable laser-bead immunoassay and different enzyme-linked immunosorbent assay (ELISA) systems. Associations between anti-Ro52/TRIM21 antibodies and clinical and other serologic manifestations of SSc were investigated. Results Anti-Ro52/TRIM21 antibodies were present in 20% of SSc patients and overlapped with other main SSc-related antibodies, including anti-centromere (by immunofluorescence and centromere protein (CENP)-A and CENP-B ELISA), anti-topoisomerase I, anti-RNA polymerase III, and anti-Pm/Scl antibodies. Anti-Ro52/TRIM21 antibodies were strongly associated with interstitial lung disease (odds ratio (OR), 1.53; 95% confidence interval (CI), 1.11 to 2.12; P = 0.0091) and overlap syndrome (OR, 2.06; 95% CI, 1.01 to 4.19; P = 0.0059). Conclusions Anti-Ro52/TRIM21 antibodies were the second most common autoantibodies in this SSc cohort. In SSc, anti-Ro52/TRIM21 antibodies may be a marker of interstitial lung disease and overlap syndrome. PMID:22394602

  6. Percutaneous endovascular management of occluded HeRO dialysis access device.

    PubMed

    Vasquez, Julio C; DeLaRosa, Jacob; Leon, Juan J; Rahim, Naeem; Rahim, Fahim

    2010-01-01

    The Hemodialysis Reliable Outflow (HeRO) device is a novel alternative for dialysis access in patients with no suitable veins in the upper extremities. We placed a HeRO device in a 67-year-old woman with end-stage renal disease and 2 months later, it was being used for hemodialysis. After 1 month of uneventful use, the device thrombosed and it was rescued with a percutaneous endovascular approach. The device remains patent 6 months after the intervention.

  7. The influence of antiscalants on biofouling of RO membranes in seawater desalination.

    PubMed

    Sweity, Amer; Oren, Yoram; Ronen, Zeev; Herzberg, Moshe

    2013-06-15

    Antiscalants are surface active polyelectrolyte compounds commonly used in reverse osmosis (RO) desalination processes to avoid membrane scaling. In spite of the significant roles of antiscalants in preventing membrane scaling, they are prone to enhance biofilm growth on RO membranes by either altering membrane surface properties or by serving as nutritional source for microorganisms. In this study, the contribution of antiscalants to membrane biofouling in seawater desalination was investigated. The effects of two commonly used antiscalants, polyphosphonate- and polyacrylate-based, were tested. The effects of RO membrane (DOW-Filmtec SW30 HRLE-400) exposure to antiscalants on its physico-chemical properties were studied, including the consequent effects on initial deposition and growth of the sessile microorganisms on the RO membrane surface. The effects of antiscalants on membrane physico-chemical properties were investigated by filtration of seawater supplemented with the antiscalants through flat-sheet RO membrane and changes in surface zeta potential and hydrophobicity were delineated. Adsorption of antiscalants to polyamide surfaces simulating RO membrane's polyamide layer and their effects on the consequent bacterial adhesion was tested using a quartz crystal microbalance with dissipation monitoring technology (QCM-D) and direct fluorescent microscopy. A significant increase in biofilm formation rate on RO membranes surface was observed in the presence of both types of antiscalants. Polyacrylate-based antiscalant was shown to enhance initial cell attachment as observed with the QCM-D and a parallel plate flow cell, due to rendering the polyamide surface more hydrophobic. Polyphosphonate-based antiscalants also increased biofilm formation rate, most likely by serving as an additional source of phosphorous to the seawater microbial population. A thicker biofilm layer was formed on the RO membrane when the polyacrylate-based antiscalant was used. Following

  8. Planets and Stellar Activity: Hide and Seek in the CoRoT-7 system

    NASA Astrophysics Data System (ADS)

    Haywood, R. D.; Cameron, A. C.; Queloz, D.; Barros, S. C. C.; Deleuil, M.; Fares, R.; Gillon, M.; Hatzes, A.; Lanza, A. F.; Lovis, C.; Moutou, C.; Pepe, F.; Pollacco, D.; Santerne, A.; Ségransan, D.; Unruh, Y.

    2014-01-01

    Since the discovery of the transiting Super-Earth CoRoT-7b, several investigations have been made of the number and precise masses of planets present in the system, but they all yield different results, owing to the star's high level of activity. Radial velocity (RV) variations induced by stellar activity therefore need to be modelled and removed to allow a reliable detection of all planets in the system. We re-observed CoRoT-7 in January 2012 with both HARPS and the CoRoT satellite, so that we now have the benefit of simultaneous RV and photometric data. We fitted the off-transit variations in the CoRoT lightcurve using a harmonic decomposition similar to that implemented in Queloz et al. (2009). This fit was then used to model the stellar RV contribution, according to the methods described by Aigrain et al. (2011). This model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b and CoRoT-7c. We also assess the evidence for the presence of one or two additional planetary companions.

  9. Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease.

    PubMed Central

    Yacyshyn, B R; Pilarski, L M

    1993-01-01

    Crohn's disease is an immunoregulatory disorder of the intestine that can be associated with systemic manifestations. This study analysed B-cell differentiation antigens to identify B-cell subpopulations unique to patients with Crohn's disease. CD45 isoform expression was used as an indicator of B-cell differentiation stage. This work shows that B-cells in blood and gut of patients with Crohn's disease are at an advanced stage of differentiation based on their unusual presentation of transitional (RA+ RO+) and late stage (RO+)CD45 isoforms on lamina propria lymphocytes, whereas normal intestinal lamina propria lymphocytes B-cells express primarily CD45RA. Crohn's disease patients had heightened expression of the CD45RO isoform on CD19+ lamina propria lymphocytes, and was found in a statistically significant proportion of Crohn's peripheral blood mononuclear cells (PBMC) where CD19+ PBMC had an expression pattern affecting an unexpectedly high proportion of these differentiated or late stage CD45RO+ B-cells. The expression of CD45RO varied greatly among CD19+ PBMC from patients with Crohn's disease, so multiple regression analysis was performed between these CD45 isoforms and several clinical parameters. After grouping high and low CD45RO expression on CD19+ B-cells, a significant statistical difference was found between high Crohn's disease activity index (CDAI) and low CDAI Crohn's disease patients respectively. PMID:7506695

  10. Characterisation of residual ionospheric errors in bending angles using GNSS RO end-to-end simulations

    NASA Astrophysics Data System (ADS)

    Liu, C. L.; Kirchengast, G.; Zhang, K. F.; Norman, R.; Li, Y.; Zhang, S. C.; Carter, B.; Fritzer, J.; Schwaerz, M.; Choy, S. L.; Wu, S. Q.; Tan, Z. X.

    2013-09-01

    Global Navigation Satellite System (GNSS) radio occultation (RO) is an innovative meteorological remote sensing technique for measuring atmospheric parameters such as refractivity, temperature, water vapour and pressure for the improvement of numerical weather prediction (NWP) and global climate monitoring (GCM). GNSS RO has many unique characteristics including global coverage, long-term stability of observations, as well as high accuracy and high vertical resolution of the derived atmospheric profiles. One of the main error sources in GNSS RO observations that significantly affect the accuracy of the derived atmospheric parameters in the stratosphere is the ionospheric error. In order to mitigate the effect of this error, the linear ionospheric correction approach for dual-frequency GNSS RO observations is commonly used. However, the residual ionospheric errors (RIEs) can be still significant, especially when large ionospheric disturbances occur and prevail such as during the periods of active space weather. In this study, the RIEs were investigated under different local time, propagation direction and solar activity conditions and their effects on RO bending angles are characterised using end-to-end simulations. A three-step simulation study was designed to investigate the characteristics of the RIEs through comparing the bending angles with and without the effects of the RIEs. This research forms an important step forward in improving the accuracy of the atmospheric profiles derived from the GNSS RO technique.

  11. Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation.

    PubMed

    Meneses, A

    2001-01-08

    The 5-HT(6) receptor antagonist Ro-04-6790 or 8-OH-DPAT injection improved learning consolidation on an autoshaping task, while mCPP, scopolamine and dizocilpine decreased the performance. The effect induced by scopolamine, but not that induced by mCPP, was reversed completely by Ro-04-6790, while dizocilpine effect was antagonized partially. Nevertheless, ritanserin or WAY 100635, but not Ro 04-6790, antagonized the 8-OH-DPAT facilitatory effects on learning consolidation. As WAY 100635 did not modify the Ro 04-6790 facilitatory effect, hence 5-HT(1A), and/or 5-HT(7), but not 5-HT(6), receptors might mediate the 8-OH-DPAT facilitatory effect on learning consolidation. Since, the Ro 04-6790 facilitatory effect was unaffected by 5-HT(1A), 5-HT(2A)/(2B)/(2C), 5-HT(3) or 5-HT(4) receptor blockade, thereby, the facilitatory effect induced by Ro 04-6790 involved specifically 5-HT(6) receptors. Indeed, the present data provide further support to the notion that, 5-HT(6) receptors play a significant part in the learning consolidation under normal and dysfunctional memory conditions.

  12. El círculo meridiano automático de San Fernando - San Juan. Sus primeros pasos en el hemisferio sur

    NASA Astrophysics Data System (ADS)

    Mallamaci, C. C.; Muiños, J. L.; Gallego, M.; Pérez, J. A.; Marmolejo, L.; Navarro, J. L.; Sedeño, J.; Vallejos, M.; Belizón, F.

    Se informa sobre el estado actual del Círculo Meridiano Automático de San Fernando-San Juan. El instrumento (Grubb-Parson, de 178mm de abertura y 2665 mm de distancia focal) es gemelo del que se encuentra en las Islas Canarias, y fue instalado durante los meses de julio y agosto de 1996 en la estación astronómica ``Dr. C.U.Cesco" (El Leoncito, Barreal), a unos 200 km de distancia de la ciudad de San Juan, merced a un Convenio de Cooperación Científica, firmado en 1994 entre el ROA (España) y el OAFA (Argentina). En la actualidad se está llevando a cabo un programa de prueba cuyos resultados preliminares muestran que el telescopio está en buenas condiciones para observar estrellas de hasta magnitud aproximada 14.5, con buenos errores de observación (<0.12" en ascensión recta y declinación).

  13. In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements.

    PubMed

    Hempel, Leonie U; Rathke, Christina; Raja, Sunil Jayaramaiah; Renkawitz-Pohl, Renate

    2006-04-01

    The genes don juan (dj) and don juan like (djl) encode basic proteins expressed in the male germline. Both proteins show a similar expression pattern being localized in the sperm heads during chromatin condensation and along the flagella. Prematurely expressed Don Juan-eGFP and Myc-Don Juan Like localize to the cytoplasm of spermatocytes and in mitochondrial derivatives from the nebenkern stage onward suggesting that both proteins associate with the mitochondria along the flagella in elongated spermatids. Premature expression of Myc-Don Juan Like does not impair spermatogenesis where-as Don Juan-eGFP when prematurely expressed causes male sterility as spermatids fail to individualize. In spite of the sequence identity of 72% on the nucleotide level and 42% on the protein level, the presumptive promoter regions and the untranslated regions of the mRNA are diverged. Our in vivo analysis revealed that don juan and don juan like are transcriptionally and translationally controlled by distinct short cis regulatory regions. Transcription of don juan and don juan like depends on the male germ line specific TAF(II)80, Cannonball (Can). Translational repression elements for both mRNAs are localized in the 5' UTR and are capable to form distinct secondary structures in close proximity to the translational initiation codon.

  14. Bedrock aquifers of eastern San Juan County, Utah

    USGS Publications Warehouse

    Avery, Charles

    1986-01-01

    This study is one of a series of studies appraising the waterbearing properties of the Navajo Sandstone and associated formations in southern Utah.  The stu<¥ area is al:x>dy area is about 4,600 square miles, extending from the Utah-Arizona State line northward to the San Juan-Grand County line and westward from the Utah-Colorado State line to the longitude of about 109°50'.Some of the water-yielding formations are grouped into aquifer systems. The C aquifer is comprised of the DeChelly Sandstone Member of the Cutler Formation.  The P aquifer is comprised of the Cedar Mesa Member of the Cutler Formation and the undifferentiated Cutler Formation. The N aquifer is comprised of the sedimentary section that includes the Wingate Sandstone, Kayenta Formation, Navajo Sandstone, Carmel Formation, and Entrada sandstone.  The M aquifer is comprised of the Bluff Sandstone Member and other sandstone units of the Morrison Formation.  The D aquifer is comprised of the Burro Canyon Formation and Dakota Sandstone.  Discharge from the ground-water reservoir to the San Juan River between gaging stations at Four Corners and Mexican Hat is about 66 cubic feet per second.The N aquifer is the main aquifer in the study area. Recharge by infiltration of precipitation is estimated to be 25,000 acre-feet per year.  A major ground-water divide exists under the broad area east of Monticello.  The thickness of the N aquifer, where the sedimentary section is fully preserved and saturated, generally is 750 to 1,250 feet.   Hydraulic conductivity values obtained from aquifer tests range from 0.02 to 0.34 foot per day.  The total volume of water in transient storage is about 11 million acre-feet. Well discharge somewhat exceeded 2,340 acre-feet during 1981.  Discharge to the San Juan River from the N aquifer is estimated to be 6.9 cubic feet per second. Water quality ranges from a calcium bicarbonate to sodium chloride type water

  15. Increasing RO efficiency by chemical-free ion-exchange and Donnan dialysis: Principles and practical implications.

    PubMed

    Vanoppen, Marjolein; Stoffels, Griet; Demuytere, Célestin; Bleyaert, Wouter; Verliefde, Arne R D

    2015-09-01

    Ion-exchange (IEX) and Donnan dialysis (DD) are techniques which can selectively remove cations, limiting scaling in reverse osmosis (RO). If the RO concentrate could be recycled for regeneration of these pre-treatment techniques, RO recovery could be largely increased without the need for chemical addition or additional technologies. In this study, two different RO feed streams (treated industrial waste water and simple tap water) were tested in the envisioned IEX-RO and DD-RO hybrids including RO concentrate recycling. The efficiency of multivalent cation removal depends mainly on the ratio of monovalent to multivalent cations in the feed stream, influencing the ion-exchange efficiency in both IEX and DD. Since the mono-to-multivalent ratio was very high in the waste water, the RO recovery could potentially be increased to 92%. For the tap water, these high RO recoveries could only be reached by adding additional NaCl, because of the low initial monovalent to multivalent ratio in the feed. In both cases, the IEX-RO hybrid proved to be most cost-efficient, due to the high current cost of the membranes used in DD. The membrane cost would have to decrease from ±300 €/m² to 10-30 €/m² - comparable to current reverse osmosis membranes - to achieve a comparable cost. In conclusion, the recycling of RO concentrate to regenerate ion exchange pre-treatment techniques for RO is an interesting option to increase RO recovery without addition of chemicals, but only at high monovalent/multivalent cation-ratios in the feed stream.

  16. Diagnostic electron microscopy and the influence of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Transmission electron microscopy (TEM) was introduced by Ruska and Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalog the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai and Rodriguez authored an important article, introducing the concept that TEM could be used for the differential diagnosis of histologically similar neoplasms. This publication heralded the steadily increasing application of TEM in anatomic pathology over the following decade, including continuing contributions by Dr. Juan Rosai. This brief review summarizes his influence on clinical electron microscopy, and lists some of the lesions for which that procedure is still a useful means of analysis.

  17. Central San Juan caldera cluster: regional volcanic framework

    USGS Publications Warehouse

    Lipman, Peter W.

    2000-01-01

    Eruption of at least 8800 km3 of dacitic-rhyolitic magma as 9 major ash-slow sheets (individually 150-5000 km3) was accompanied by recurrent caldera subsidence between 28.3 and about 26.5 Ma in the central San Juan Mountains, Colorado. Voluminous andesitic-decitic lavas and breccias were erupted from central volcanoes prior to the ash-flow eruptions, and similar lava eruptions continued within and adjacent to the calderas during the period of explosive volcanism, making the central San Juan caldera cluster an exceptional site for study of caldera-related volcanic processes. Exposed calderas vary in size from 10 to 75 km in maximum diameter, the largest calderas being associated with the most voluminous eruptions. After collapse of the giant La Garita caldera during eruption if the Fish Canyon Tuff at 17.6 Ma, seven additional explosive eruptions and calderas formed inside the La Garita depression within about 1 m.y. Because of the nested geometry, maximum loci of recurrently overlapping collapse events are inferred to have subsided as much as 10-17 km, far deeper than the roof of the composite subvolcanic batholith defined by gravity data, which represents solidified caldera-related magma bodies. Erosional dissection to depths of as much as 1.5 km, although insufficient to reach the subvolcanic batholith, has exposed diverse features of intracaldera ash-flow tuff and interleaved caldera-collapse landslide deposits that accumulated to multikilometer thickness within concurrently subsiding caldera structures. The calderas display a variety of postcollapse resurgent uplift structures, and caldera-forming events produced complex fault geometries that localized late mineralization, including the epithermal base- and precious-metal veins of the well-known Creede mining district. Most of the central San Juan calderas have been deeply eroded, and their identification is dependent on detailed geologic mapping. In contrast, the primary volcanic morphology of the

  18. Sea level Variability and Juan de Fuca Bathymetry

    NASA Astrophysics Data System (ADS)

    Huybers, P. J.; Boulahanis, B.; Proistosescu, C.; Langmuir, C. H.; Carbotte, S. M.; Katz, R. F.

    2015-12-01

    That deglaciation influences mid-ocean ridge volcanism is well established for Iceland, where depressurization associated with melting a ~2 km ice cap led to order of magnitude increases in volcanism during the last deglaciation. The case was also made that the more subtle ~100 m changes in sea level that accompany glacial cycles have identifiable implications for undersea mid-ocean ridge systems using both models and data from the Australian-Antarctic Ridge (Crowley et al., 2015). Sea level rising at ~1 cm/year during deglaciation leads to an expectation of ~10% decreases in melt production at ridges, given mantle upwelling rates of ˜3 cm/yr at intermediate spreading ridges and mantle density being ~3 times that of seawater. The implications of variations in melt production for bathymetry, however, involve numerous considerations, including whether melt signals are cancelled within the melt column, appreciably alter accretionary or fault processes, and have identifiable surface expressions. Further empirical assessment of bathymetry is thus useful for purposes of confirming patterns and constraining processes. Here we report on spectral analyses of bathymetry recently acquired from the Juan de Fuca ridge between 44°30'N and 45°15'N during the SeaVOICE expedition. Multibeam swath sonar data were acquired with an EM122 sonar insonfiying seafloor to crustal ages of ˜2 ma with 35 m spatial resolution. We examine (1.) the statistical significance of concentrations of bathymetric variability at the 100 ky, 41 ky, and 23 ky periods characteristic of late-Pleistocene sea level variability; (2.) whether sea level responses are primarily at 41 ky periods in crust accreted during the early Pleistocene, when global sea level variations were primarily at this period; and (3.) if sea level responses are superimposed on bathymetry variations or, instead, align with fault features. We also note that Juan de Fuca's proximity to the Cordilleran Ice Sheet implies that regional

  19. The fate of Don Juan: the myth and the man.

    PubMed

    Brockman, D D

    1992-01-01

    The literary character of Don Juan has offered an opportunity to study certain characteristics in an adult man who began a behavior pattern in adolescence that resembled the legendary and mythical Don Juan. Power and dominating control issues were paramount defenses against a narcissistic depression in this man as seen in his relationships with women and in the transference relationship with me. The transference data have been put to use in providing a formulation for an explanation of the phenomena observed. Other clinical data concerning women and some homosexual men are presented in a more abbreviated fashion. This research effort is a retrospective construction of the dynamics that led to this man's neurosis. In my opinion, a self psychological interpretation offers the more felicitous fit than the classic oedipal interpretation. In fact, at first I tried interpretations based on classic oedipal theory--concerning issues of competition with me as father and fear of retaliation and castration--but this strategy resulted in little or no response. More important than symptomatic response, however, the data minimally and weakly supported those interpretations. To be sure, there were and still are competitive and phallic oedipal issues. Moreover, when the patient's mother died, he was drawn into a closer relationship with his father, a relationship accompanied by wishes and fantasies of taking his mother's place. These wishes were quite real, but, as the analysis preceeded, this negative oedipal configuration occupied a much less prominent place in the dynamics. Power and control issues dominated the clinical picture, masking a depression emanating from a deeper narcissistic focus. Interpretation of these narcissistic issues provided my patient with the relief he was seeking, while the main effect of the antidepressant medication was to help him sleep. By giving him something, a deeply seated wish was gratified and was in keeping with an idealized mother

  20. Deglaciation and postglacial timberline in the San Juan Mountains, Colorado

    USGS Publications Warehouse

    Carrara, P.E.; Mode, W.N.; Rubin, M.; Robinson, S.W.

    1984-01-01

    Lake Emma, which no longer exists because of a mining accident, was a tarn in a south-facing cirque near the headwaters of the Animas River in the San Juan Mountains of southwestern Colorado. During the Pinedale glaciation, this area was covered by a large transection glacier centered over the Lake Emma region. Three radiocarbon dates on basal organic sediment from Lake Emma indicate that by ca. 15,000 yr B.P. this glacier, one of the largest in the southern Rocky Mountains, no longer existed. Twenty-two radiocarbon dates on Picea and Abies krummholz fragments in the Lake Emma deposits indicate that from ca. 9600 to 7800 yr B.P., from 6700 to 5600 yr B.P., and at 3100 yr B.P. the krummholz limit was at least 70 m higher than present. These data, in conjunction with Picea:Pinus pollen ratios from both the Lake Emma site and the Hurricane Basin site of J. T. Andrews, P. E. Carrara, F. B. King, and R. Struckenrath (1975, Quaternary Research 5, 173-197) suggest than from ca. 9600 to 3000 yr B.P. timberline in the San Juan Mountains was higher than present. Cooling apparently began ca. 3000 yr B.P. as indicated by decreases in both the percentage of Picea pollen and Picea:Pinus pollen ratios at the Hurricane Basin site (Andrews et al., 1975). Cooling is also suggested by the lack of Picea or Abies fragments younger than 3000 yr B.P. at either the Lake Emma or the Hurricane Basin site. ?? 1984.

  1. Don Juan Basin, Wright Valley, Antarctica: Model for Surface Processes on Mars

    NASA Astrophysics Data System (ADS)

    Englert, P.; Bishop, J. L.; Gibson, E. K.; Patel, S.; Koeberl, C.

    2014-09-01

    Mineral, chemical, and soluble salt composition of drill core samples from Don Juan Basin, Wright Valley, Antarctica, indicate that the formation of the most saline terrestrial pond may include groundwater discharge and near surface flow processes.

  2. Letter to Silverton and San Juan County Regarding Potential Superfund Listing

    EPA Pesticide Factsheets

    Feb. 12, 2016 Update: EPA added a letter to the Town of Silverton and San Juan County regarding the agency’s commitment to the Town and County’s involvement during a potential Superfund listing process.

  3. Juan de Fuca plate: Aseismic subduction at 1. 8 cm/yr

    SciTech Connect

    Acharya, H.

    1981-11-01

    Volcanic activity in the Cascades in historic times suggests that the Juan de Fuca plate is underthrusting aseismically at about 1.8 cm/yr. This rate of underthrusting is identical to the rate computed from sediment studies.

  4. RoBlock: a prototype autonomous manufacturing cell

    NASA Astrophysics Data System (ADS)

    Baekdal, Lars K.; Balslev, Ivar; Eriksen, Rene D.; Jensen, Soren P.; Jorgensen, Bo N.; Kirstein, Brian; Kristensen, Bent B.; Olsen, Martin M.; Perram, John W.; Petersen, Henrik G.; Petersen, Morten L.; Ruhoff, Peter T.; Skjolstrup, Carl E.; Sorensen, Anders S.; Wagenaar, Jeroen M.

    2000-10-01

    RoBlock is the first phase of an internally financed project at the Institute aimed at building a system in which two industrial robots suspended from a gantry, as shown below, cooperate to perform a task specified by an external user, in this case, assembling an unstructured collection of colored wooden blocks into a specified 3D pattern. The blocks are identified and localized using computer vision and grasped with a suction cup mechanism. Future phases of the project will involve other processes such as grasping and lifting, as well as other types of robot such as autonomous vehicles or variable geometry trusses. Innovative features of the control software system include: The use of an advanced trajectory planning system which ensures collision avoidance based on a generalization of the method of artificial potential fields, the use of a generic model-based controller which learns the values of parameters, including static and kinetic friction, of a detailed mechanical model of itself by comparing actual with planned movements, the use of fast, flexible, and robust pattern recognition and 3D-interpretation strategies, integration of trajectory planning and control with the sensor systems in a distributed Java application running on a network of PC's attached to the individual physical components. In designing this first stage, the aim was to build in the minimum complexity necessary to make the system non-trivially autonomous and to minimize the technological risks. The aims of this project, which is planned to be operational during 2000, are as follows: To provide a platform for carrying out experimental research in multi-agent systems and autonomous manufacturing systems, to test the interdisciplinary cooperation architecture of the Maersk Institute, in which researchers in the fields of applied mathematics (modeling the physical world), software engineering (modeling the system) and sensor/actuator technology (relating the virtual and real worlds) could

  5. MBR/RO/ozone processes for TFT-LCD industrial wastewater treatment and recycling.

    PubMed

    Chen, T K; Ni, C H; Chan, Y C; Lu, M C

    2005-01-01

    This research is mainly to explore the treatment capacity for TFT-LCD industrial wastewater recycling by the processes combined with membrane bioreactor (MBR), reverse osmosis (RO) and ozone(O3). The organic wastewater from the TFT-LCD industry was selected as the target. MBR, RO and ozone plants were established for evaluation. An MBR plant consisted of a 2-stage anoxic/aerobic bioreactor and an immersed UF membrane unit was employed. The effluent of MBR was conducted into the RO system then into the ozone system. The RO system consisted of a spiral membrane in the vessel. One bubble column, 75 cm high and diameter 5 cm, were used as the ozonation reactor. On the bottom of ozonation reactor is a porous diffuser for releasing gas, with an aperture of 100 microm (0.1 cm). Over the whole experimental period, the MBR process achieved a satisfactory organic removal. The COD could be removed with an average of over 98.5%. For the TOC item, the average removal efficiency was 97.4%. The stable effluent quality and satisfactory removal performance were ensured by the efficient interception performance of an immersed UF membrane device incorporated with the biological reactor. Moreover, the MBR effluent did not contain any suspended solids and the SDI value was under 3. After the treatment of RO, excellent water quality was found. The water quality of permeate was under 5 mg/I, 2 mg/l and 50 micros/cm for COD, TOC and conductivity respectively. The treated water can be recycled and reused for the cooling tower make-up water or other purposes. After the treatment of ozone, the treated water quality was under 5 mg/l and 0.852 mg/l for COD and TOC respectively. The test results of MBR, MBR/RO and MBR/RO/ozone processes were compared as possible appropriate treatment technologies applied in TFT-LCD industrial wastewater reuse and recycling.

  6. Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

    PubMed

    Klotz, U; Ziegler, G; Rosenkranz, B; Mikus, G

    1986-11-01

    Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subsequently to an oral loading dose (0.54 g ethanol kg-1) ethanol was infused for 4 h (0.15 g ethanol kg-1 h-1) and steady state blood levels between 0.9 to 1.2 g l-1 were reached within 2 h. At steady state and during the elimination phase of ethanol an intravenous bolus of 0.5 mg Ro 15-1788 or placebo was administered in a randomized, double-blind crossover fashion. The marked sedative effects of ethanol as assessed by visual analogue scales (2 to 6 fold increase in the sedation index), and choice reaction time (25 to 40% prolongation) were not affected by Ro 15-1788. However, the pharmaco-EEG indicated that Ro 15-1788 seems to reverse transiently the ethanol-induced changes in total alpha, delta, and slow alpha bands. There was no pharmacokinetic interaction between both agents since elimination of Ro 15-1788 (t1/2 = 1.2 +/- 0.7 h) and of ethanol (0.17 +/- 0.02 g l-1 h-1) were in good agreement with control values. Thus, it could be concluded that Ro 15-1788 might affect for a short while the action of ethanol by interfering with the benzodiazepine receptors.

  7. Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa.

    PubMed

    Santel, A; Blümer, N; Kämpfer, M; Renkawitz-Pohl, R

    1998-11-01

    The Drosophila don juan gene encodes a basic protein (Don Juan protein), which is solely expressed postmeiotically during spermiogenesis in elongated spermatids and in mature sperm. Transgenic expression of a GFP-tagged Don Juan protein (DJ-GFP) in the male germ line showed an association of the fusion protein with the sperm tail. Detailed examination of DJ-GFP localization revealed novel insights into its distinct temporal and spatial distribution along the sperm tail during the last phase of spermatid maturation. Co-localization of DJ-GFP with actin-labeled cysts demonstrated its emergence in elongated spermatids during individualization. Additionally, the endogenous Don Juan protein was detected with epitope-specific antibodies in finally elongated nuclei of spermatids. After completion of nuclear shaping Don Juan is no longer detectable in the sperm heads with the onset of individualization. Mislocalization of the DJ-GFP protein in flagella of a mutant with defective mitochondrial differentiation provides evidence of mitochondrial association of the fusion protein with flagellar mitochondrial arrays. Ectopically expressed DJ-GFP in premeiotic germ cells as well as salivary gland cells confirmed the capability of the fusion protein to associate with mitochondria. Therefore we suppose that Don Juan is a nuclear-encoded, germ-cell specifically expressed mitochondrial protein, which might be involved in the final steps of mitochondrial differentiation within the flagellum.

  8. From CoRoT 102899501 to the Sun. A time evolution model of chromospheric activity on the main sequence

    NASA Astrophysics Data System (ADS)

    Gondoin, P.; Gandolfi, D.; Fridlund, M.; Frasca, A.; Guenther, E. W.; Hatzes, A.; Deeg, H. J.; Parviainen, H.; Eigmüller, P.; Deleuil, M.

    2012-12-01

    , inferred using a parameterization of the stellar rotation period as a function of colour index and time established for the I-sequence of stars in stellar clusters. Conclusions: We conclude that the high magnetic activity level and fast rotation of CoRoT 102899501 are manifestations of its stellar youth consistent with its estimated evolutionary status and with the detection of a strong Li i λ6707.8 Å absorption line in its spectrum. We argue that a magnetic activity level comparable to that observed on CoRot 102899501 could have been present on the Sun at the time of planet formation. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain.Based on observations made with the Anglo-Australian Telescope; the 2.1-m Otto Struve telescope at McDonald Observatory, Texas, USA; the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias, in time allocated by the NOT "Fast-Track" Service Programme, OPTICON, and the Spanish Time Allocation Committee (CAT).The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number RG226604 (OPTICON).

  9. Speckle Imaging of Kepler and CoRoT Exo-planet Transit Candidate Stars

    NASA Astrophysics Data System (ADS)

    Howell, Steve B.; Horch, Elliott; Sherry, William; Ciardi, David

    2010-08-01

    Kepler and CoRoT are complementary space missions dedicated to the detection of exoplanets. The primary science goal of CoRoT is to find Neptune-sized (>3 Earth radii) planets in intermediate orbits, while the prime science goal of Kepler is to find Earth-sized planets (<3 Earth radii) in year-long orbits. Both missions employ the photometric transit method and both spacecraft are performing well with nominal operation of the spacecraft, telescopes, electronics, and instruments. As with ground-based surveys, Kepler and CoRoT candidates need to be screened for background eclipsing binary stars which, when photometrically blended with the primary target, can mimic exo-planetary transits. The list of candidate transiting planets found by Kepler/CoRoT requires follow-up to ascertain probable or certain exo- planet detection. While Earth-sized (and Neptune-sized in long orbital periods) exo-planets can not currently (easily) be confirmed from the ground, many of the false positive eliminations steps can be performed by ground-based observations. Follow-up for Kepler exo-planet candidates is now aimed at Neptune-size and smaller planets in longer period orbits. This proposal aims to obtain high resolution speckle imaging to observe Kepler/CoRoT exo-planet transit candidates in order to eliminate the largest false positive contributor in any transit search - background eclipsing binary stars or faint companion stars.

  10. Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508)

    SciTech Connect

    Maughan, T.S.; Newman, H.F.; Bleehen, N.M.; Ward, R.; Workman, P. )

    1990-05-01

    The hypoxic cell radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole) are under evaluation as single agents (Phase III) and in combination (Phase I). Ro 03-8799 produces an acute, transient central nervous system syndrome, whereas SR 2508 causes cumulative, peripheral neurotoxicity; both effects are dose-limiting. Pharmacokinetic studies have shown the importance of area under the plasma drug concentration versus time curve (AUC) in predicting the risk of peripheral neuropathy. Most patients have very similar pharmacokinetic parameters. This study reports 2/25 patients receiving 0.75 g/m2 Ro 03-8799 plus 2.0 g/m2 SR 2508 who showed significant discrepancies in drug handling. One patient exhibited a markedly elevated AUC and prolonged t1/2 beta for SR 2508 and this was associated with an unusually rapid onset of peripheral neuropathy. A second patient showed normal handling of SR 2508 but prolonged values for both t1/2 alpha and t1/2 beta for Ro 03-8799 and unusually low levels of its N-oxide metabolite. In addition a low peak Ro 03-8799 concentration combined with a very high volume of distribution was found in this patient, leading to a normal AUC value and toxicity profile. Both patients exhibited a relatively low creatinine clearance. The mechanisms which may underlie these findings are discussed, and the importance of pharmacokinetic monitoring in the use of these agents is emphasized.

  11. Data Analysis Provenance: Use Case for Exoplanet Search in CoRoT Database

    NASA Astrophysics Data System (ADS)

    de Souza, L.; Salete Marcon Gomes Vaz, M.; Emílio, M.; Ferreira da Rocha, J. C.; Janot Pacheco, E.; Carlos Boufleur, R.

    2012-09-01

    CoRoT (COnvection Rotation and Planetary Transits) is a mission led by the French national space agency CNES, in collaboration with Austria, Spain, Germany, Belgium and Brazil. The mission priority is dedicated to exoplanet search and stellar seismology. CoRoT light curves database became public after one year of their delivery to the CoRoT Co-Is, following the CoRoT data policy. The CoRoT archive contains thousands of light curves in FITS format. Several exoplanet search algorithms require detrend algorithms to remove both stellar and instrumental signal, improving the chance to detect a transit. Different detrend and transit detection algorithms can be applied to the same database. Tracking the origin of the information and how the data was derived in each level in the data analysis process is essential to allow sharing, reuse, reprocessing and further analysis. This work aims at applying a formalized and codified knowledge model by means of domain ontology. It allows to enrich the data analysis with semantic and standardization. It holds the provenance information in the database for a posteriori recovers by humans or software agents.

  12. Research and development of Ro-boat: an autonomous river cleaning robot

    NASA Astrophysics Data System (ADS)

    Sinha, Aakash; Bhardwaj, Prashant; Vaibhav, Bipul; Mohommad, Noor

    2013-12-01

    Ro-Boat is an autonomous river cleaning intelligent robot incorporating mechanical design and computer vision algorithm to achieve autonomous river cleaning and provide a sustainable environment. Ro-boat is designed in a modular fashion with design details such as mechanical structural design, hydrodynamic design and vibrational analysis. It is incorporated with a stable mechanical system with air and water propulsion, robotic arms and solar energy source and it is proceed to become autonomous by using computer vision. Both "HSV Color Space" and "SURF" are proposed to use for measurements in Kalman Filter resulting in extremely robust pollutant tracking. The system has been tested with successful results in the Yamuna River in New Delhi. We foresee that a system of Ro-boats working autonomously 24x7 can clean a major river in a city on about six months time, which is unmatched by alternative methods of river cleaning.

  13. WE-B-Exhibit Hall-01: Ask the RO-ILS Experts

    SciTech Connect

    Ezzell, G; Sanscrainte, E; Tomlinson, C

    2015-06-15

    Have a question about RO-ILS: Radiation Oncology Incident Learning System™, or interested in learning more? Sponsored by the American Society for Radiation Oncology (ASTRO) and AAPM, RO-ILS is the only medical specialty society-sponsored incident learning system for radiation oncology. It facilitates safer and higher quality care in radiation oncology by providing a mechanism for shared learning in a secure and non-punitive environment. Please join our RO-ILS experts for a question and answer session on Wednesday, July 15th at 8:30 in the Partners in Solutions Room in Exhibit Hall C. Our experts include: Gary Ezzell, PhD, Mayo Clinic Arizona, [Brett Miller, Phillip Beron, and Derek Brown], Emily Sanscrainte from Clarity PSO and Cindy Tomlinson, MPP, ASTRO.

  14. Removal of bisphenol A (BPA) from water by various nanofiltration (NF) and reverse osmosis (RO) membranes.

    PubMed

    Yüksel, Suna; Kabay, Nalan; Yüksel, Mithat

    2013-12-15

    The removal of an endocrine disrupting compound, bisphenol A (BPA), from model solutions by selected nanofiltration (NF) and reverse osmosis (RO) membranes was studied. The commercially available membranes NF 90, NF 270, XLE BWRO, BW 30 (Dow FilmTech), CE BWRO and AD SWRO (GE Osmonics) were used to compare their performances for BPA removal. The water permeability coefficients, rejection of BPA and permeate flux values were calculated for all membranes used. No significant changes in their BPA removal were observed for all tight polyamide based NF and RO membranes tested except for loose NF 270 membrane. The polyamide based membranes exhibited much better performance than cellulose acetate membrane for BPA removal. Almost a complete rejection (≥ 98%) for BPA was obtained with three polyamide based RO membranes (BW 30, XLE BWRO and AD SWRO). But cellulose acetate based CE BWRO membrane offered a low and variable (10-40%) rejection for BPA.

  15. Local rotundity structure of Cesàro-Orlicz sequence spaces

    NASA Astrophysics Data System (ADS)

    Foralewski, Pawel; Hudzik, Henryk; Szymaszkiewicz, Alicja

    2008-09-01

    Some criteria for extreme points and strong U-points in Cesàro-Orlicz spaces are given. In consequence we find a Cesàro-Orlicz sequence space different from c0 which has no extreme points. Some examples show that in these spaces the notion of the strong U-point is essentially stronger than the notion of the extreme point. Various examples presented in this paper show that there are some differences between criteria for extreme points and strong U-points in Orlicz spaces and in Cesàro-Orlicz spaces. We also show that the uniqueness of the local best approximation needs the notion of SU-point, that is, the notion of the extreme point is not strong enough here.

  16. On the spectrum of the Cesàro operator on spaces of analytic functions

    NASA Astrophysics Data System (ADS)

    Persson, Anna-Maria

    2008-04-01

    This paper concerns the Cesàro operator acting on various spaces of analytic functions on the unit disc. The remarkable fact that this operator is subnormal when acting on the Hardy space H2 has lead to extensive studies of its spectral picture on other spaces of this type. We present some of the methods that have been used to obtain information about the spectrum of the Cesàro operator acting on Hardy and Bergman spaces and give a unified approach to these problems which also yields new results in this direction. In particular, we prove that the Cesàro operator is subdecomposable on H1 and on the standard weighted Bergman spaces , [alpha][greater-or-equal, slanted]0.

  17. The study of Be stars with the CoRoT satellite

    NASA Astrophysics Data System (ADS)

    Diago, P. D.; Gutierrez-Soto, J.; Fabregat, J.; Suso, J.; COROT Be Team

    2011-11-01

    The CoRoT space mission, launched in December 2006, is a spacecraft devoted to the study of the stellar interiors and the exo-planet search. Concerning the seismology of the Be stars, the presence of pulsations in late-type Be stars is still a matter of controversy. It constitutes an important issue to establish the relationship between non-radial pulsations and the mass-loss mechanism in Be stars. In this field, the CoRoT satellite is providing data with an unprecedent quality and precision that is confirming non-radial pulsations in Be stars. The CoRoT Be Team is an international collaboration composed by members from France, Spain, Brazil and Belgium and is in charge of the exploitation and analysis of the Be stars data. In this work we present the highlighted results of the observed Be stars by CoRoT and the future prospects of the CoRoT Be Team. These results include the detection of the Be star HD 49 330 during an outburst phase and the measurement of the change in the oscillation spectrum during this rare event. These observations gave insight into the nature of the explosion. It will help to solve a question that has been pending for years: are oscillations the cause of the outbursts? Moreover, for the first time, the CoRoT satellite has detected simultaneously the rotational and the pulsational frequencies for the Be star HD 50 209, which constitutes a proof of the presence of pulsations in the Be stars. %J Highlights of Spanish Astrophysics VI, Proceedings of the IX Scientific Meeting of the Spanish Astronomical Society (SEA), held in Madrid, September 13 - 17, 2010, Eds.: M. R. Zapatero Osorio, J. Gorgas, J. Maiz Apellaniz, J. R. Pardo, and A. Gil de Paz., p. 531-531

  18. Planetary transit candidates in the CoRoT-SRc01 field

    NASA Astrophysics Data System (ADS)

    Erikson, A.; Santerne, A.; Renner, S.; Barge, P.; Aigrain, S.; Alapini, A.; Almenara, J.-M.; Alonso, R.; Auvergne, M.; Baglin, A.; Benz, W.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Cabrera, J.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Deleuil, M.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Ofir, A.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rabus, M.; Rauer, H.; Régulo, C.; Rouan, D.; Samuel, B.; Schneider, J.; Shporer, A.; Tingley, B.; Udry, S.; Wuchterl, G.

    2012-03-01

    Context. The space mission CoRoT is devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. Aims: We present the list of planetary transit candidates detected in the first short run observed by CoRoT that targeted SRc01, towards the Galactic center in the direction of Aquila, which lasted from April to May 2007. Methods: Among the acquired data, we analyzed those for 1269 sources in the chromatic bands and 5705 in the monochromatic band. Instrumental noise and the stellar variability were treated with several detrending tools, to which several transit-search algorithms were subsequently applied. Results: Fifty-one sources were classified as planetary transit candidates and 26 were followed up with ground-based observations. Until now, no planet has been detected in the CoRoT data from the SRc01 field. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with contributions from Austria, Belgium, Brazil, ESA, Germany, and Spain. The CoRoT data are available to the community from the CoRoT archive: http://idoc-corot.ias.u-psud.frBased in part on observations made with the 1.93-m telescope at Observatoire de Haute Provence (CNRS), France (SOPHIE Program 08A.PNP.MOUT).Based in part on observations made with the ESO-3.60-m telescope at La Silla Observatory (ESO), Chile (HARPS Program ESO - 081.C-0388) and with the ESO-VLT telescope at Paranal Observatory (ESO), Chile (FLAMES Program ESO - 081.C-0413).

  19. EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

    SciTech Connect

    Deleuil, M.; Meunier, J. C.; Moutou, C.; Surace, C.; Barbieri, M.; Agneray, F.; Granet, Y.; Guterman, P.; Deeg, H. J.; Almenara, J. M.; Hodgkin, S.

    2009-08-15

    Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic plane around CoRoT pointings, with a total area of 209 deg{sup 2}. This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.

  20. Transiting exoplanets from the CoRoT space mission. XX. CoRoT-20b: A very high density, high eccentricity transiting giant planet

    NASA Astrophysics Data System (ADS)

    Deleuil, M.; Bonomo, A. S.; Ferraz-Mello, S.; Erikson, A.; Bouchy, F.; Havel, M.; Aigrain, S.; Almenara, J.-M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Bordé, P.; Bruntt, H.; Cabrera, J.; Carpano, S.; Cavarroc, C.; Csizmadia, Sz.; Damiani, C.; Deeg, H. J.; Dvorak, R.; Fridlund, M.; Hébrard, G.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Jorda, L.; Léger, A.; Lammer, H.; Mazeh, T.; Moutou, C.; Ollivier, M.; Ofir, A.; Parviainen, H.; Queloz, D.; Rauer, H.; Rodríguez, A.; Rouan, D.; Santerne, A.; Schneider, J.; Tal-Or, L.; Tingley, B.; Weingrill, J.; Wuchterl, G.

    2012-02-01

    We report the discovery by the CoRoT space mission of a new giant planet, CoRoT-20b. The planet has a mass of 4.24 ± 0.23 MJup and a radius of 0.84 ± 0.04 RJup. With a mean density of 8.87 ± 1.10 g cm-3, it is among the most compact planets known so far. Evolutionary models for the planet suggest a mass of heavy elements of the order of 800 M⊕ if embedded in a central core, requiring a revision either of the planet formation models or both planet evolution and structure models. We note however that smaller amounts of heavy elements are expected by more realistic models in which they are mixed throughout the envelope. The planet orbits a G-type star with an orbital period of 9.24 days and an eccentricity of 0.56.The star's projected rotational velocity is vsini = 4.5 ± 1.0 km s-1, corresponding to a spin period of 11.5 ± 3.1 days if its axis of rotation is perpendicular to the orbital plane. In the framework of Darwinian theories and neglecting stellar magnetic breaking, we calculate the tidal evolution of the system and show that CoRoT-20b is presently one of the very few Darwin-stable planets that is evolving toward a triple synchronous state with equality of the orbital, planetary and stellar spin periods. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain.

  1. Transiting exoplanets from the CoRoT space mission. V. CoRoT-Exo-4b: stellar and planetary parameters

    NASA Astrophysics Data System (ADS)

    Moutou, C.; Bruntt, H.; Guillot, T.; Shporer, A.; Guenther, E.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barbieri, M.; Barge, P.; Benz, W.; Bordé, P.; Bouchy, F.; Deeg, H. J.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gillon, M.; Gondoin, P.; Hatzes, A.; Hébrard, G.; Jorda, L.; Kabath, P.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Magain, P.; Mayor, M.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rabus, M.; Rauer, H.; Rouan, D.; Schneider, J.; Udry, S.; Wuchterl, G.

    2008-09-01

    Aims: The CoRoT satellite has announced its fourth transiting planet (Aigrain et al. 2008, A&A, 488, L43) with space photometry. We describe and analyse complementary observations of this system performed to establish the planetary nature of the transiting body and to estimate the fundamental parameters of the planet and its parent star. Methods: We have analysed high precision radial-velocity data, ground-based photometry, and high signal-to-noise ratio spectroscopy. Results: The parent star CoRoT-Exo-4 (2MASS 06484671-0040219) is a late F-type star of mass of 1.16 M⊙ and radius of 1.17 R⊙. The planet has a circular orbit with a period of 9.20205 d. The planet radius is 1.19 R_Jup and the mass is 0.72 M_Jup. It is a gas-giant planet with a “normal” internal structure of mainly H and He. CoRoT-Exo-4b has the second longest period of the known transiting planets. It is an important discovery since it occupies an empty area in the mass-period diagram of transiting exoplanets. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain; and on observations made with the SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07B.MOUT), and the HARPS spectrograph at ESO La Silla Observatory (079.C-0127/F). Table 2 and Fig. 5 are only available in electronic form at http://www.aanda.org

  2. CoRoT archive as a treasury of variable stars

    NASA Astrophysics Data System (ADS)

    Benko, Jozsef M.; Paparo, Margit

    2015-08-01

    The CoRoT satellite supported the scientific community by a huge data base of variable stars. The investigation of RR Lyrae stars (radially pulsating classical variable stars of high amplitude), especially benefit the continuous space data, due to long periodicity. The CoRoT RR Lyrae stars were intensively discussed in numerous papers in the last few years, but the latest runs have not been checked for finding RR Lyrae stars up to now. We found eight new RR Lyrae stars that we investigated for the lately localized characteristics of Blazhko RR Lyrae stars: the period doubling and additional modes. We present the preliminary results here.

  3. Fetal manifestations of maternal anti‐Ro and La antibodies – more than complete heart block

    PubMed Central

    2015-01-01

    Abstract Complete heart block (CHB) is a potentially fatal condition occurring in approximately 1:10000 fetuses. Whilst it is well recognised that maternal anti‐Ro and La antibodies are associated with fetal CHB, there are multiple other manifestations of fetal exposure to these autoantibodies which are not widely appreciated and rarely diagnosed. The importance of identifying affected fetuses lies in the significantly increased risk of recurrence in future pregnancies, and the potential for treatments which may modify this risk. This paper presents several cases to highlight the varying fetal presentations of maternal anti‐Ro and La antibodies. PMID:28191254

  4. Multiple star systems observed with CoRoT and Kepler

    NASA Astrophysics Data System (ADS)

    Southworth, John

    2015-09-01

    The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

  5. Transiting exoplanets from the CoRoT space mission. III. The spectroscopic transit of CoRoT-Exo-2b with SOPHIE and HARPS

    NASA Astrophysics Data System (ADS)

    Bouchy, F.; Queloz, D.; Deleuil, M.; Loeillet, B.; Hatzes, A. P.; Aigrain, S.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Benz, W.; Bordé, P.; Deeg, H. J.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Guillot, T.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Mayor, M.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pepe, F.; Pont, F.; Rauer, H.; Rouan, D.; Schneider, J.; Triaud, A. H. M. J.; Udry, S.; Wuchterl, G.

    2008-05-01

    We report on the spectroscopic transit of the massive hot-Jupiter CoRoT-Exo-2b observed with the high-precision spectrographs SOPHIE and HARPS. By modeling the radial velocity anomaly occurring during the transit due to the Rossiter-McLaughlin (RM) effect, we determine the sky-projected angle between the stellar spin and the planetary orbital axis to be close to zero λ = 7.2 ± 4.5 deg, and we secure the planetary nature of CoRoT-Exo-2b. We discuss the influence of the stellar activity on the RM modeling. Spectral analysis of the parent star from HARPS spectra are presented. Observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07A.MOUT) and HARPS spectrograph at ESO La Silla Observatory (079.C-0127(F)). The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.

  6. Transiting exoplanets from the CoRoT space mission. II. CoRoT-Exo-2b: a transiting planet around an active G star

    NASA Astrophysics Data System (ADS)

    Alonso, R.; Auvergne, M.; Baglin, A.; Ollivier, M.; Moutou, C.; Rouan, D.; Deeg, H. J.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Benz, W.; Bordé, P.; Bouchy, F.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gillon, M.; Gondoin, P.; Guillot, T.; Hatzes, A.; Hébrard, G.; Kabath, P.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Magain, P.; Mayor, M.; Mazeh, T.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rauer, H.; Shporer, A.; Schneider, J.; Stecklum, B.; Udry, S.; Wuchterl, G.

    2008-05-01

    Context: The CoRoT mission, a pioneer in exoplanet searches from space, has completed its first 150 days of continuous observations of ~12 000 stars in the galactic plane. An analysis of the raw data identifies the most promising candidates and triggers the ground-based follow-up. Aims: We report on the discovery of the transiting planet CoRoT-Exo-2b, with a period of 1.743 days, and characterize its main parameters. Methods: We filter the CoRoT raw light curve of cosmic impacts, orbital residuals, and low frequency signals from the star. The folded light curve of 78 transits is fitted to a model to obtain the main parameters. Radial velocity data obtained with the SOPHIE, CORALIE and HARPS spectrographs are combined to characterize the system. The 2.5 min binned phase-folded light curve is affected by the effect of sucessive occultations of stellar active regions by the planet, and the dispersion in the out of transit part reaches a level of 1.09×10-4 in flux units. Results: We derive a radius for the planet of 1.465 ± 0.029 R_Jup and a mass of 3.31 ± 0.16 M_Jup, corresponding to a density of 1.31 ± 0.04 g/cm^3. The large radius of CoRoT-Exo-2b cannot be explained by current models of evolution of irradiated planets. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain; and on observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07 A.MOUT), CORALIE, and HARPS spectrograph at ESO La Silla Observatroy (079.C-0127/F)). Table 2 is only available in electronic form at http://www.aanda.org

  7. San Juan basin faulting - More than meets eye

    SciTech Connect

    Huffman, A.C. Jr.; Taylor, D.J. )

    1989-09-01

    Interpretation of approximately 1,000 mi of seismic lines throughout the San Juan basin, New Mexico, has revealed a rectilinear pattern of high-angle faults with dominant trends of N60-70{degree}W and N30-40{degree}E. Vertical fault separation in the plane of section is commonly 150-250 ft, measured at the top of the basement. Strike-slip movement on many faults is also indicated by the map pattern, but no reliable measurements have yet been made. The authors analysis of the movement history of several faults indicates three significant episodes of movement: Pennsylvanian to Permian, Jurassic to Cretaceous, and early to middle Tertiary. Sense of movement on many of the faults varied episodically so that the present basement offset is actually cumulative offset representing all previous periods of movement. Above Permian strata, actual offset on most faults is not detectable on seismic sections; however, drape and measurable differences in thickness across fault zones are commonly exhibited by Mesozoic rocks.

  8. Basalt Geochemistry of the Endeavour Segment, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Woodcock, J. P.; Gill, J.; Kela, J.; Michael, P.; Ramos, F.

    2006-12-01

    We present new trace element, volatile, isotope, and modeling data for mid-ocean ridge basalts (MORB) from the Endeavour Axial Ridge Volcano (EARV) segment of the Juan de Fuca Ridge. Endeavour MORB are categorized to a first order using K2O/TiO2, with T-MORB = 0.15-0.25, N-MORB lower, and E- MORB higher. Within these groups, there are 2 subgroups of N-MORB and 3 of T-MORB, distinguished by differences in Si8, Fe8, Ti8, and differentiation paths. Liquid lines of descent are best explained by crystallization within the crust at measured water contents (0.2-0.5 wt. %). EARV basalts exhibit spatial heterogeneities that far exceed what can be explained by these fractional crystallization models. Incompatible trace element ratios such as Zr/Nb, La/Yb, and K2O/TiO2 exhibit 3- to 4-fold variations, indicating heterogeneity of source or melting processes. The heterogeneity is observed along axis in samples only tens to hundreds of meters apart and is most prominent along the western wall of the axial valley, suggesting that axial magma chambers may be short-lived. Despite their heterogeneity, axial samples have nearly constant 87Sr/86Sr and ^{143}Nd/^{144}Nd ratios. Pb isotopes are more variable (206Pb/204Pb = 18.35-18.90). The heterogeneity seems unrelated to the chemical influence of a plume or the thermal perturbations of a transform fault.

  9. Fruit and fertility in San Juan de la Manguana.

    PubMed

    Mckenna, N D

    1995-01-01

    Ana Irsa (Nisoris) Aquina, 39, a mother of seven, grandmother, wife, and voluntary community health facilitator, lives in the Dominican Republic. Nisoris counsels women and their partners about reproductive health, provides child survival information to new mothers, and dispenses common remedies for diarrhea and respiratory infections as well as contraceptives (mainly oral contraceptives and condoms). These supplies are financed by Fundacion para el Desarrollo Communitario (FUDECO), a nongovernmental agency which is a member of the Save the Children alliance. FUDECO's work includes the development of water systems, health services, schools, and soil conservation training. Widespread deforestation in the San Juan area has led to a reduction in self-sufficient farming and a lack of nutrition evidenced by an increase in infant blindness caused by Vitamin A deficiency. To combat this situation, FUDECO has taught the women's group led by Nisoris how to use solar power to dry fruits and vegetables to preserve them for consumption beyond their season. The pilot group has in turn taught six other women's groups and conducted informal product sampling and Vitamin A information sessions in the local market. FUDECO provides supplies and technical expertise. The program has been so successful that the women are exploring packaging options so that they can sell the dried produce.

  10. Ro-vibrational Stark effect on H2 and D2 molecules adsorbed in NaA zeolite

    NASA Astrophysics Data System (ADS)

    Bras, N.

    1999-03-01

    In order to explain the induced infrared bands of H2 and D2 adsorbed in NaA zeolites the Stark effect on the ro-vibrational levels of these molecules is considered for electric fields created by various charge distributions. The shift and intensity of the induced ro-vibration transitions are calculated.

  11. Establishment of rock bream Oplegnathus fasciatus embryo (RoBE-4) cells with cytolytic infection of red seabream iridovirus (RSIV).

    PubMed

    Oh, So-Young; Nishizawa, Toyohiko

    2016-12-01

    Red seabream iridovirus (RSIV) is a member of genus Megalocytivirus in the family Iridoviridae. RSIV infection causes significant economic losses of marine-fishes in East Asian countries. Grunt fin (GF) cell line has been commonly used for culturing RSIV. However, it is not suitable for definite evaluation of infectivity titer of RSIV because cells infected with RSIV are not completely cytolysed. Thus, we established a new cell line, RoBE-4, from rock bream (Oplegnathus fasciatus) eyed-egg embryos in this study. Morphologically, RoBE-4 cells were fibroblastic-like. They have been stably grown over two-years with 60 passages using Leibovitz's L-15 medium containing 10% (v/v) fetal bovine serum. RoBE-4 cells infected with RSIV exhibited cytopathic effects (CPE) with cell rounding. They were cytolysed completely after ≥2 weeks of culture. Numerous RSIV particles with icosahedral morphology of approximately 122nm in diameter were observed in cytoplasmic area of infected RoBE-4 cells. The RSIV-suceptibility and amount of extracellular RSIV released by RoBE-4 cells were 100-fold higher than those by GF cells. RSIV cultured with RoBE-4 cells was highly virulent to rock bream in infection experiments. Therefore, using RoBE-4 cells instead of GF cells will enable accurate and sensitive measurement of RSIV infectivity. In addition, RoBE-4 cells might be used to produce RSIV vaccine in the future with significant reduction in cost.

  12. Map Showing Susceptibility to Earthquake-Induced Landsliding, San Juan Metropolitan Area, Puerto Rico

    USGS Publications Warehouse

    Santiago, Marilyn; Larsen, Matthew C.

    2001-01-01

    Analysis of slope angle and rock type using a geographic information system indicates that about 68 percent of the San Juan metropolitan area has low to no susceptibility to earthquake-induced landslides. This is at least partly due to the fact that 45 percent of the San Juan metropolitan area is constructed on slopes of 3 degrees or less, which are too gentle for landslides to occur. The areas with the highest susceptibility to earthquake-induced landslides account for 6 percent of the surface area. Almost one-quarter (24 percent) of the San Juan metropolitan area is moderately susceptible to earthquake-induced landslides. These areas are mainly in the southern portions of the San Juan metropolitan area, where housing development pressures are currently high because of land availability and the esthetics of greenery and hillside views. The combination of new development and moderate earthquake-induced landslide susceptibility indicate that the southern portions of the San Juan metropolitan area are be at greatest risk.

  13. Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

    PubMed Central

    McCauliffe, D P; Lux, F A; Lieu, T S; Sanz, I; Hanke, J; Newkirk, M M; Bachinski, L L; Itoh, Y; Siciliano, M J; Reichlin, M

    1990-01-01

    Ro/SS-A antibodies are found in a number of human autoimmune disorders including Sjogren's syndrome and several systemic lupus erythematosus-related disorders. These heterogeneous autoantibodies are known to recognize several distinct cellular antigens. With synthetic oligonucleotides corresponding to amino acid sequence information we have isolated a full-length cDNA clone which encodes a human Ro ribonucleoprotein autoantigen. The 1,890-base pair clone contains an open reading frame that encodes a 417-amino acid, 48-kD polypeptide that migrates aberrantly at 60 kD by SDS-PAGE. Rabbit antibodies raised against this protein's recently described amino-terminal epitope react with a previously identified 52-kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs. Ultraviolet light cross-linking studies suggest that this Ro protein binds each of the four major human cytoplasmic RNAs. The deduced amino acid sequence is 63% homologous to an Onchocerca volvulus antigen. Southern filter hybridization analysis indicates that this gene is not highly polymorphic and exists as a single copy in the human genome. Chromosomal localization studies place this gene on the short arm of chromosome 19 near the gene encoding the low density lipoprotein receptor. Images PMID:2332496

  14. RO filtration of biologically treated textile and dyeing effluents using ozonation as a pre-treatment.

    PubMed

    Wang, H Y; Guan, Y T; Mizuno, T; Tsuno, H

    2010-01-01

    Bench-scale experiments were conducted to investigate the application of ozonation pre-treatment for biologically treated textile and dyeing wastewater to improve performance of the RO process. Based on ozonation experiments, four specific ozone consumptions (SOC), 0, 0.3, 0.6, 4.0 mg O₃/mg DOC₀ were chosen for study of the effects of ozonation on the reverse osmosis (RO) process. Membrane flux was recorded. Also, the permeate water quality parameters such as TOC, conductivity were analyzed. In addition, fouled membrane cleaning was studied. The study further examined the nature and mechanisms of membrane fouling using scanning electron microscopy (SEM) and the energy dispersive X-ray spectrometer (EDS). The effect of ozonation on RO filtration was found to depend on SOC. The study revealed that significant improvement can be achieved in the efficiency of RO filtration by employing ozonation with 0.6 mg O₃/mg DOC₀ SOC. Although the product water purity slightly decreased, the ozonation pre-treatment showed advantages at 0.6 mg O₃/mg DOC₀ SOC for the following: (i) mitigation of flux decline due to membrane fouling; (ii) improvement in foulants cleanability. In addition, hypotheses were put forward to explain the reasons from the aspect of organic matter characteristics changed by ozonation, such as changing on functional groups and molecular weight of organic matter.

  15. Uncovering the planets and stellar activity of CoRoT-7 using only radial velocities

    NASA Astrophysics Data System (ADS)

    Faria, J. P.; Haywood, R. D.; Brewer, B. J.; Figueira, P.; Oshagh, M.; Santerne, A.; Santos, N. C.

    2016-04-01

    Stellar activity can induce signals in the radial velocities of stars, complicating the detection of orbiting low-mass planets. We present a method to determine the number of planetary signals present in radial-velocity datasets of active stars, using only radial-velocity observations. Instead of considering separate fits with different number of planets, we use a birth-death Markov chain Monte Carlo algorithm to infer the posterior distribution for the number of planets in a single run. In a natural way, the marginal distributions for the orbital parameters of all planets are also inferred. This method is applied to HARPS data of CoRoT-7. We confidently recover the orbits of both CoRoT-7b and CoRoT-7c although the data show evidence for the presence of additional signals. All data and software presented in this article are available online at http://https://github.com/j-faria/exoBD-CoRoT7

  16. Draft Genome Sequence of the Xylella fastidiosa CoDiRO Strain

    PubMed Central

    Chiumenti, Michela; Saponari, Maria; Donvito, Giacinto; Italiano, Alessandro; Loconsole, Giuliana; Boscia, Donato; Cariddi, Corrado; Martelli, Giovanni Paolo; Saldarelli, Pasquale

    2015-01-01

    We determined the draft genome sequence of the Xylella fastidiosa CoDiRO strain, which has been isolated from olive plants in southern Italy (Apulia). It is associated with olive quick decline syndrome (OQDS) and characterized by extensive scorching and desiccation of leaves and twigs. PMID:25676759

  17. RoMPS concept review automatic control of space robot, volume 2

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1991-01-01

    Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form and include: (1) system concept; (2) Hitchhiker Interface Requirements; (3) robot axis control concepts; (4) Autonomous Experiment Management System; (5) Zymate Robot Controller; (6) Southwest SC-4 Computer; (7) oven control housekeeping data; and (8) power distribution.

  18. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension

    PubMed Central

    Guerreso, Kelsey; Conner, Edward Alexander

    2016-01-01

    Introduction There are many different causes of pulmonary hypertension and the pathogenesis of the disease is still being elucidated. Although they are not the most common, autoimmunity and inflammation have been identified as possible causes. No one autoantibody has been identified as the definite cause of pulmonary hypertension. We present a rare association of anti-SSA/Ro antibodies and isolated pulmonary hypertension. Case presentation A 53 year old African American female presented with abdominal pain, nausea, weight loss, dyspnea and fatigue. Upon further exam she was found to have high titers of antinuclear antibodies and anti-SSA/Ro antibodies. This antibody profile would typically be suggestive of Sjögren's Syndrome, which is characterized by dry eyes and poor salivary gland function. However, since this patient did not have any symptoms consistent with the disease a diagnosis of Sjögren's Syndrome could not be made. A combination of laboratory, imaging and diagnostic studies were done that revealed a final diagnosis of pulmonary hypertension. Conclusion It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension. PMID:27222785

  19. CoRoT-2a Magnetic Activity: Hints for Possible Star-Planet Interaction

    NASA Astrophysics Data System (ADS)

    Pagano, Isabella; Lanza, Antonino F.; Leto, Giuseppe; Messina, Sergio; Barge, Pierre; Baglin, Annie

    2009-09-01

    CoRoT-2a is a young (≈0.5 Gyr) G7V star accompanied by a transiting hot-Jupiter, discovered by the CoRoT satellite (Alonso et al. Astron Astrophys 482:L21, 2008; Bouchy et al. Astron Astrophys 482:L25, 2008). An analysis of its photospheric activity, based on spot modelling techniques previously developed by our group for the analysis of the Sun as a star, shows that the active regions on CoRoT-2a arised within two active longitudes separated by about 180° and rotating with periods of 4.5221 and 4.5543 days, respectively, at epoch of CoRoT observations (112 continous days centered at ≈2007.6). We show that the total spotted area oscillates with a period of about 28.9 days, a value close to 10 times the synodic period of the planet with respect to the active longitude pattern rotating in 4.5221 days. Moreover, the variance of the stellar flux is modulated in phase with the planet orbital period. This suggests a possible star-planet magnetic interaction, a phenomenon already seen in other extrasolar planetary systems hosting hot-Jupiters.

  20. Jean Vigo's "Zéro De Conduite" and the Spaces of Revolt

    ERIC Educational Resources Information Center

    Vanobbergen, Bruno; Grosvenor, Ian; Simon, Frank

    2014-01-01

    In this article we will contribute to the contemporary theoretical debate about film by considering, from a history-of-education perspective, the film "Zéro de conduite" by Jean Vigo (1905--1934). This film is classified under the umbrella of "poetic realism": a product of "cinéma de gauche" and an avant-gardist,…

  1. Variation in Herrnstein's ro as a function of alternative reinforcement rate

    PubMed Central

    Dougan, James D.; McSweeney, Frances K.

    1985-01-01

    In a test of Herrnstein's (1970, 1974) equation for simple schedules, 15 pigeons pecked a key that produced food delivered according to variable-interval schedules. One group of birds was water deprived, and food-reinforced key pecking occurred in the presence of free water. Two other groups were not water deprived; water was present for one and absent for the other. As predicted by Herrnstein, the parameter ro was significantly higher in the water-deprived group than in the two nondeprived groups. Contrary to Herrnstein's interpretation of ro, the rate of drinking varied across schedules. Herrnstein's interpretation can be salvaged by considering ro to be an average. However, if ro is an average, the equation is not a good explanation of behavior because this average is not valid until all schedules have been sampled. In addition, low percentages of variance accounted for suggest that Herrnstein's equation may be of limited usefulness even as a descriptive model for these situations. PMID:16812413

  2. Spectral characterization and differential rotation study of active CoRoT stars

    NASA Astrophysics Data System (ADS)

    Nagel, E.; Czesla, S.; Schmitt, J. H. M. M.

    2016-05-01

    The CoRoT space telescope observed nearly 160 000 light curves. Among the most outstanding is that of the young, active planet host star CoRoT-2A. In addition to deep planetary transits, the light curve of CoRoT-2A shows strong rotational variability and a superimposed beating pattern. To study the stars that produce such an intriguing pattern of photometric variability, we identified a sample of eight stars with rotation periods between 0.8 and 11 days and photometric variability amplitudes of up to 7.5%, showing a similar CoRoT light curve. We also obtained high-resolution follow-up spectroscopy with TNG/SARG and carried out a spectral analysis with SME and MOOG. We find that the color dependence of the light curves is consistent with rotational modulation due to starspots and that latitudinal differential rotation provides a viable explanation for the light curves, although starspot evolution is also expected to play an important role. Our MOOG and SME spectral analyses provide consistent results, showing that the targets are dwarf stars with spectral types between F and mid-K. Detectable Li i absorption in four of the targets confirms a low age of 100-400 Myr also deduced from gyrochronology. Our study indicates that the photometric beating phenomenon is likely attributable to differential rotation in fast-rotating stars with outer convection zones.

  3. A New Method for Detecting and Monitoring Atmospheric Natural Hazards with GPS RO

    NASA Astrophysics Data System (ADS)

    Biondi, R.; Steiner, A. K.; Rieckh, T. M.; Kirchengast, G.

    2014-12-01

    Global Positioning System (GPS) Radio Occultation (RO) allows measurements in any meteorological condition, with global coverage, high vertical resolution, and high accuracy. With more than 13 years of data availability, RO also became a fundamental tool for studying climate change. We present here the application of RO for detecting and monitoring tropical cyclones (TCs), deep convective systems (CSs) and volcanic ash clouds (ACs).Deep CSs and TCs play a fundamental role in atmospheric circulation producing vertical transport, redistributing water vapor and trace gases, changing the thermal structure of the Upper Troposphere and Lower Stratosphere (UTLS) and affecting climate through overshooting into the stratosphere. Explosive volcanic eruptions produce large ACs dangerous for the aviation and they can impact climate when the ash is injected into the UTLS.The detection of cloud top height, the determination of cloud extent, the discrimination of ACs from CSs clouds and the detection of overshooting are main challenges for atmospheric natural hazards study. We created a reference atmosphere with a resolution of 5° in latitude and longitude, sampled on a 1° x 1° grid, and a vertical sampling of 100 m. We then compared RO profiles acquired during TCs, CSs and ACs to the reference atmosphere and computed anomaly profiles.CSs, TCs and the ACs leave a clear signature in the atmosphere which can be detected by RO. Using RO temperature and bending angle profiles we gain insight into the vertical thermal structure and developed a new method for detecting the cloud top altitude with high accuracy.We have characterized the TCs by ocean basins and intensities, showing that they have a different thermal structure and reach to different altitudes according to the basin. We provide statistics on overshooting frequency, achieving results consistent with patterns found in the literature and demonstrating that RO is well suited for this kind of study. We have analyzed the

  4. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

    PubMed Central

    Liang, Yayun; Mafuvadze, Benford; Aebi, Johannes D; Hyder, Salman M

    2016-01-01

    Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration); however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4′-[6-(allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071) (RO), which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway), on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ) protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the growth of aggressive castration-resistant human prostate cancer cell xenografts in vivo without any signs of toxicity to experimental animals. Importantly, RO did not reduce the viability of normal prostate cells in vitro. Our study is the first to demonstrate that the cholesterol biosynthesis inhibitor RO effectively suppresses growth of human prostate cancer cells

  5. Occurrence, quality, and use of ground water in Orcas, San Juan, Lopez, and Shaw Islands, San Juan County, Washington

    USGS Publications Warehouse

    Whiteman, K.J.; Molenaar, Dee; Jacoby, J.M.; Bortleson, G.V.

    1983-01-01

    Ground water, which supplies most of San Juan County 's water needs, occurs in both bedrock and glacial drift. Water in the bedrock occurs in fractures in the otherwise dense, poorly permeable rock. Deposits of sand and gravel in the glacial drift provide the best yields to wells drilled into unconsolidated materials. Specific capacities of bedrock wells are typically low, and those of glacial-drift wells considerably higher. Ground water is high in dissolved solids and hardness; 29 of 56 wells sampled had water classified as very hard. Sixteen percent of the 171 ground-water sites tested for indicator bacteria had positive counts of one or more of these bacteria: total coliform , fecal coliform, fecal streptococcus. Nine percent of the 279 wells sampled for chloride in September 1981, appear to be affected by seawater intrusion. All of these wells are located within a mile of the coast; 60 percent of these wells are on Lopez Island. In 1980 an estimated total of 220 million gallons of ground water was withdrawn for all uses. Ninety percent of all ground-water use is for domestic and public supply purposes. Heavy pumpage on northern and southern Lopez Island correlates with areas having high chloride concentrations. (USGS)

  6. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  7. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  8. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  9. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  10. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  11. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  12. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  13. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  14. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  15. 78 FR 28800 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Application for Subzone; Parapiezas Corporation; San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, Puerto Rico; Application for Subzone; Parapiezas Corporation; San Juan, Puerto Rico An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Puerto Rico Trade &...

  16. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  17. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  18. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  19. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  20. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  1. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  2. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  3. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  4. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  5. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sector San Juan Marine Inspection..., DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AREAS, DISTRICTS, SECTORS, MARINE INSPECTION ZONES, AND CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection...

  6. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.

    PubMed

    Debeb, Bisrat G; Cohen, Evan N; Boley, Kimberly; Freiter, Erik M; Li, Li; Robertson, Fredika M; Reuben, James M; Cristofanilli, Massimo; Buchholz, Thomas A; Woodward, Wendy A

    2012-07-01

    Basal breast cancer, common among patients presenting with inflammatory breast cancer (IBC), has been shown to be resistant to radiation and enriched in cancer stem cells. The Notch pathway plays an important role in self-renewal of breast cancer stem cells and contributes to inflammatory signaling which promotes the breast cancer stem cell phenotype. Herein, we inhibited Notch signaling using a gamma secretase inhibitor, RO4929097, in an in vitro model that enriches for cancer initiating cells (3D clonogenic assay) and conventional 2D clonogenic assay to compare the effect on radiosensitization of the SUM149 and SUM190 IBC cell lines. RO4929097 downregulated the Notch target genes Hes1, Hey1, and HeyL, and showed a significant reduction in anchorage independent growth in SUM190 and SUM149. However, the putative self-renewal assay mammosphere formation efficiency was increased with the drug. To assess radiosensitization of putative cancer stem cells, cells were exposed to increasing doses of radiation with or without 1 μM RO4929097 in their standard (2D) and self-renewal enriching (3D) culture conditions. In the conventional 2D clonogenic assay, RO4929097 significantly sensitized SUM190 cells to ionizing radiation and has a modest radiosensitization effect in SUM149 cells. In the 3D clonogenic assays, however, a radioprotective effect was seen in both SUM149 and SUM190 cells at higher doses. Both cell lines express IL-6 and IL-8 cytokines known to mediate the efficacy of Notch inhibition and to promote self-renewal of stem cells. We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-α, a potential mediator of IL-6 and IL-8 production in the microenvironment. These data suggest that additional targeting agents may be required to selectively target IBC stem cells through Notch inhibition, and that evaluation of microenvironmental influences may shed further light on the potential effects of this inhibitor.

  7. A Phase II Study of RO4929097 Gamma-Secretase Inhibitor in Metastatic Melanoma: SWOG 0933

    PubMed Central

    Lee, Sylvia M.; Moon, James; Redman, Bruce G.; Chidiac, Tarek; Flaherty, Lawrence E.; Zha, Yuanyuan; Othus, Megan; Ribas, Antoni; Sondak, Vernon K.

    2014-01-01

    Background Aberrant Notch activation confers a proliferative advantage onto many human tumors, including melanoma. This phase II trial assessed the antitumor activity of RO4929097, a gamma-secretase inhibitor of Notch signaling, on the progression-free and overall survival of patients with advanced melanoma. Methods Chemotherapy-naïve patients with metastatic melanoma of cutaneous or unknown origin were treated with RO4929097 at a dose of 20 mg orally daily, 3 consecutive days per week. A two-step accrual design was used, with an interim analysis on the first 32 patients, and continuation of enrollment if ≥4/32 patients responded. Results Thirty-six patients from 23 institutions were enrolled; 32 patients were evaluable. RO4929097 was well-tolerated, and most toxicities were grade 1 or 2. The most common toxicities were nausea (53%), fatigue (41%), and anemia (22%). There was 1 confirmed partial response lasting 7 months, and 8 patients with stable disease lasting at least through week 12, with one of these continuing for 31 months. The 6-month PFS was 9% (95% CI: 2–22%), and 1-year OS was 50% (95% CI: 32–66%). Peripheral blood T cell assays showed no significant inhibition of IL-2 production, a surrogate pharmacodynamic marker of Notch inhibition, suggesting that the drug levels were insufficient to achieve Notch target inhibition. Conclusions RO4929097 showed minimal clinical activity against metastatic melanoma in this phase II trial, possibly due to inadequate exposure to therapeutic drug levels. While Notch inhibition remains a compelling target in melanoma, our results do not support further investigation of RO4929097 at this dose and schedule. PMID:25250858

  8. Expression of the Memory Marker CD45RO on Helper T Cells in Macaques

    PubMed Central

    Valentine, Michael; Song, Kejing; Maresh, Grace A.; Mack, Heather; Huaman, Maria Cecilia; Polacino, Patricia; Ho, On; Cristillo, Anthony; Kyung Chung, Hye; Hu, Shiu-Lok; Pincus, Seth H.

    2013-01-01

    Background In humans it has been reported that a major site of the latent reservoir of HIV is within CD4+ T cells expressing the memory marker CD45RO, defined by the mAb UCHL1. There are conflicting reports regarding the expression of this antigen in macaques, the most relevant animal species for studying HIV pathogenesis and testing new therapies. There is now a major effort to eradicate HIV reservoirs and cure the infection. One approach is to eliminate subsets of cells housing the latent reservoir, using UCHL1 to target these cells. So that such studies may be performed in macaques, it is essential to determine expression of CD45RO. Methods We have used immunofluorescence and flow cytometry to study cell surface expression of CD45RO on lymphocytes from PBMC, lymphoid, and GI organs of rhesus, pigtailed, and cynomolgus macaques. Both direct and indirect immunofluorescence experiments were performed. Findings CD45RO is expressed on a subset of CD4+ lymphocytes of all pigtailed, a fraction of rhesus, and neither of the cynomolgus macaques studied. The binding of UCHL1 to macaque cells was of lower avidity than to human cells. This could be overcome by forming UCHL1 multimers. Directly conjugating fluors to UCHL1 can inhibit UCHL1 binding to macaque cells. Patterns of UCHL1 expression differ somewhat in macaques and humans, and from that of other memory markers often used in macaques. Conclusions CD45RO, defined with mAb UCHL1, is well expressed on CD4+ cells in pigtailed macaques. Using tissues recovered from latently infected pigtailed macaques we are determining whether UCHL1, or other memory markers, can define the cellular locus of the reservoir. The low avidity of this interaction could limit the utility of UCHL1, in its conventional form, to eliminate cells in vivo and test this approach in macaque models of HIV infection. PMID:24023920

  9. The Juan non-LTR retrotransposon in mosquitoes: genomic impact, vertical transmission and indications of recent and widespread activity

    PubMed Central

    Biedler, James K; Tu, Zhijian

    2007-01-01

    Background In contrast to DNA-mediated transposable elements (TEs), retrotransposons, particularly non-long terminal repeat retrotransposons (non-LTRs), are generally considered to have a much lower propensity towards horizontal transfer. Detailed studies on site-specific non-LTR families have demonstrated strict vertical transmission. More studies are needed with non-site-specific non-LTR families to determine whether strict vertical transmission is a phenomenon related to site specificity or a more general characteristic of all non-LTRs. Juan is a Jockey clade non-LTR retrotransposon first discovered in mosquitoes that is widely distributed in the mosquito family Culicidae. Being a non-site specific non-LTR, Juan offers an opportunity to further investigate the hypothesis that non-LTRs are genomic elements that are primarily vertically transmitted. Results Systematic analysis of the ~1.3 Gbp Aedes aegypti (Ae. aegypti) genome sequence suggests that Juan-A is the only Juan-type non-LTR in Aedes aegypti. Juan-A is highly reiterated and comprises approximately 3% of the genome. Using minimum cutoffs of 90% length and 70% nucleotide (nt) identity, 663 copies were found by BLAST using the published Juan-A sequence as the query. All 663 copies are at least 95% identical to Juan-A, while 378 of these copies are 99% identical to Juan-A, indicating that the Juan-A family has been transposing recently in evolutionary history. Using the 0.34 Kb 5' UTR as the query, over 2000 copies were identified that may contain internal promoters, leading to questions on the genomic impact of Juan-A. Juan sequences were obtained by PCR, library screening, and database searches for 18 mosquito species of six genera including Aedes, Ochlerotatus, Psorophora, Culex, Deinocerites, and Wyeomyia. Comparison of host and Juan phylogenies shows overall congruence with few exceptions. Conclusion Juan-A is a major genomic component in Ae. aegypti and it has been retrotransposing recently in

  10. A jewel in the desert: BHP Billiton's San Juan underground mine

    SciTech Connect

    Buchsbaum, L.

    2007-12-15

    The Navajo Nation is America's largest native American tribe by population and acreage, and is blessed with large tracks of good coal deposits. BHP Billiton's New Mexico Coal Co. is the largest in the Navajo regeneration area. The holdings comprise the San Juan underground mine, the La Plata surface mine, now in reclamation, and the expanding Navajo surface mine. The article recounts the recent history of the mines. It stresses the emphasis on sensitivity to and helping to sustain tribal culture, and also on safety. San Juan's longwall system is unique to the nation. It started up as an automated system from the outset. Problems caused by hydrogen sulfide are being tackled. San Juan has a bleederless ventilation system to minimise the risk of spontaneous combustion of methane and the atmospheric conditions in the mine are heavily monitored, especially within the gob areas. 3 photos.

  11. Segmented Subduction Across the Juan De Fuca Plate: Challenges in Imaging with an Amphibious Array

    NASA Astrophysics Data System (ADS)

    Hawley, W. B.; Allen, R. M.

    2014-12-01

    The Cascadia Initiative (CI) is an amphibious array spanning the Juan de Fuca plate from formation at the ridge to the destruction of the slab in the mantle beneath western North America. This ambitions project has occupied over 300 onshore and offshore sites, providing an unprecedented opportunity to understand the dynamics of oceanic plates. The CI project is now in its fourth and final year of deployment. Here we present constraints on the structure of the Juan de Fuca plate and its interaction with western North America. We identify segmentation along the Cascadia subduction zone that can be traced back onto the Juan de Fuca plate prior to subduction. These results give insight into the life cycle of oceanic plates, from their creation at a mid-ocean ridge to their subduction and subsequent recycling into the mantle.

  12. Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR

    PubMed Central

    Morin, Cory W.; Monaghan, Andrew J.; Hayden, Mary H.; Barrera, Roberto; Ernst, Kacey

    2015-01-01

    Meteorological factors influence dengue virus ecology by modulating vector mosquito population dynamics, viral replication, and transmission. Dynamic modeling techniques can be used to examine how interactions among meteorological variables, vectors and the dengue virus influence transmission. We developed a dengue fever simulation model by coupling a dynamic simulation model for Aedes aegypti, the primary mosquito vector for dengue, with a basic epidemiological Susceptible-Exposed-Infectious-Recovered (SEIR) model. Employing a Monte Carlo approach, we simulated dengue transmission during the period of 2010–2013 in San Juan, PR, where dengue fever is endemic. The results of 9600 simulations using varied model parameters were evaluated by statistical comparison (r2) with surveillance data of dengue cases reported to the Centers for Disease Control and Prevention. To identify the most influential parameters associated with dengue virus transmission for each period the top 1% of best-fit model simulations were retained and compared. Using the top simulations, dengue cases were simulated well for 2010 (r2 = 0.90, p = 0.03), 2011 (r2 = 0.83, p = 0.05), and 2012 (r2 = 0.94, p = 0.01); however, simulations were weaker for 2013 (r2 = 0.25, p = 0.25) and the entire four-year period (r2 = 0.44, p = 0.002). Analysis of parameter values from retained simulations revealed that rain dependent container habitats were more prevalent in best-fitting simulations during the wetter 2010 and 2011 years, while human managed (i.e. manually filled) container habitats were more prevalent in best-fitting simulations during the drier 2012 and 2013 years. The simulations further indicate that rainfall strongly modulates the timing of dengue (e.g., epidemics occurred earlier during rainy years) while temperature modulates the annual number of dengue fever cases. Our results suggest that meteorological factors have a time-variable influence on dengue transmission relative to other important

  13. Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR.

    PubMed

    Morin, Cory W; Monaghan, Andrew J; Hayden, Mary H; Barrera, Roberto; Ernst, Kacey

    2015-08-01

    Meteorological factors influence dengue virus ecology by modulating vector mosquito population dynamics, viral replication, and transmission. Dynamic modeling techniques can be used to examine how interactions among meteorological variables, vectors and the dengue virus influence transmission. We developed a dengue fever simulation model by coupling a dynamic simulation model for Aedes aegypti, the primary mosquito vector for dengue, with a basic epidemiological Susceptible-Exposed-Infectious-Recovered (SEIR) model. Employing a Monte Carlo approach, we simulated dengue transmission during the period of 2010-2013 in San Juan, PR, where dengue fever is endemic. The results of 9600 simulations using varied model parameters were evaluated by statistical comparison (r2) with surveillance data of dengue cases reported to the Centers for Disease Control and Prevention. To identify the most influential parameters associated with dengue virus transmission for each period the top 1% of best-fit model simulations were retained and compared. Using the top simulations, dengue cases were simulated well for 2010 (r2 = 0.90, p = 0.03), 2011 (r2 = 0.83, p = 0.05), and 2012 (r2 = 0.94, p = 0.01); however, simulations were weaker for 2013 (r2 = 0.25, p = 0.25) and the entire four-year period (r2 = 0.44, p = 0.002). Analysis of parameter values from retained simulations revealed that rain dependent container habitats were more prevalent in best-fitting simulations during the wetter 2010 and 2011 years, while human managed (i.e. manually filled) container habitats were more prevalent in best-fitting simulations during the drier 2012 and 2013 years. The simulations further indicate that rainfall strongly modulates the timing of dengue (e.g., epidemics occurred earlier during rainy years) while temperature modulates the annual number of dengue fever cases. Our results suggest that meteorological factors have a time-variable influence on dengue transmission relative to other important

  14. Prevalence of the Metabolic Syndrome in San Juan, Puerto Rico

    PubMed Central

    Pérez, Cynthia M.; Guzmán, Manuel; Ortiz, Ana P.; Estrella, Mayra; Valle, Yari; Pérez, Naydi; Haddock, Lillian; Suárez, Erick

    2009-01-01

    Objective The metabolic syndrome is associated with a high risk of diabetes and cardiovascular disease, and Hispanics in the United States have higher rates than do other ethnic groups. We assessed the prevalence of the metabolic syndrome and its individual components in Puerto Rican adults. Methods We conducted a cross-sectional study that used a probability cluster design to select a sample of households of the San Juan metropolitan area from 2005 through 2007. A total of 859 persons aged 21–79 years completed a face-to-face interview, blood pressure and waist circumference measurements, and blood sampling. Our primary outcome measure was metabolic syndrome as defined by the updated NCEP-ATP criteria. Results Prevalence of the metabolic syndrome was 43.3%; 45.3% for men and 42.2% for women (P>.05). Prevalence significantly rose with age, from 12.8% among participants aged 21–29 years to 58.2% for participants aged 70–79 years (P<.001). Corresponding increases in the prevalence of the metabolic syndrome in both men and women were also observed; the prevalence peaked in men aged 50–59 years (62.6%) and in women aged 70–79 years (65.2%). Elevated glucose (49.8%) and abdominal obesity (49.0%) were the most common components of the metabolic syndrome, followed by elevated blood pressure (46.1%), reduced high-density lipoprotein cholesterol (46.0%), and elevated triglycerides (31.3%). Substantial variations were found between men and women in the prevalence of individual components. Conclusions Puerto Ricans have a high prevalence of the metabolic syndrome. This health disparity has implications for diabetes and cardiovascular prevention programs. PMID:19157247

  15. Diagnosing a male hysteric: Don Juan-type.

    PubMed

    Lubbe, Trevor

    2003-08-01

    The aim of this paper is to provide a clinical account of a male hysteric, Don Juan-type, taken from the early stages of treatment. The patient presented with a relationship problem but there soon emerged a form of compulsive sexuality or hypersexuality in his love relations that became a central feature of the clinical picture. This hypersexuality expressed itself in a compulsive need to stage, or to stage-manage, interpersonal scenaria of a sexual or sexualised nature. These scenaria, which were repeated in different variations and with different personnel, are seen by the author as a dramatisation of the primal scene with the patient taking up the position of the oedipal father. Explanations for the disappearance of male hysteria are given, including a new theory which claims that an imbalance in psychoanalytic theory itself led to the feminisation of hysteria. This critique allows certain forms of hypersexuality in men to be promoted as a form of hysteria, the most common example being Don Juanism-a form of compulsive sexuality that encompasses normative, conversion and character features. The paper also examines the male hysteric's developmental agenda. What the patient's compulsive sexual tableaux exposed was that he had never faced a separation that was not a triangular experience. This meant that his separations were experienced as two developmental agonies telescoped into one-separation (pre-oedipal) and exclusion (early oedipal). This combination, the author suggests, is so frightening in a particular group of men as to explain the choice of hysteria as opposed to some other choice of neurosis.

  16. The Yale/San Juan Southern Proper Motion Program

    NASA Astrophysics Data System (ADS)

    van Altena, W. F.; Girard, T. M.; Platais, I.; Kozhurina-Platais, V.; Ostheimer, J.; Lopez, C. E.; Mendez, R. A.

    1999-09-01

    The SPM is based on photographic plates taken at our observatory at El Leoncito, Argentina and will yield absolute proper motions and positions to magnitude B 19 for approximately 1 million stars south of declination -20 degrees. The SPM is a joint program between the Yale Southern Observatory and the Universidad Nacional de San Juan, Argentina. The SPM Catalog 2.0 provides positions, absolute proper motions, and photographic BV photometry for over 320,000 stars and galaxies. All objects contained in the SPM 1.0 Catalog (the South Galactic Pole region) are also included in this version. Note that SPM 1.0 has been replaced by SPM 1.1 which has slightly different astrometry (mostly proper motions) due to refinement of the magnitude equation correction in the SPM 2.0 Catalog. The Catalog covers an area of 3700 square degrees in an irregularly bounded band between declinations of -43 and -22 degrees, but excluding fields in the plane of the Milky Way. Stars cover the magnitude range 5 < V < 18.5. The standard errors for the best measured stars are as follows: 20 mas for positions in each coordinate; 2 mas/yr for absolute proper motions and 0.05 mag in B and V bandpasses. In addition to the Catalog, a list of CCD calibrating sequences in BV is provided. It contains 7783 stars. The new feature of the Catalog is an extensive list of cross-identifications with external special catalogs which include all major astrometric catalogs and a large number of astrophysically interesting objects. The Catalog is available on the WWW at http://www.astro.yale.edu/astrom/. Our web-site contains several useful plots showing the sky coverage, error distribution, a quick comparison with the Hipparcos proper motions, etc.

  17. Laramide tectonic evolution of San Juan sag, Colorado: Implications of Animas and Blanco basin formations

    SciTech Connect

    Brister, B.S. )

    1989-09-01

    The lower member of the Animas Formation (McDermott Member) is a volcaniclastic sequence derived from a north-northwest source (San Juan-La Plata area). It consists of purple andesitic debris flows, green fan-delta sandstones and mud rocks, and dark gray conglomerates with clast compositions indicating that the Precambrian core of the source uplift was exposed. The upper member is a sand-dominated alluvial plain sequence deposited by southwest-flowing braided streams. It includes green-gray-brown carbonaceous mudstones and pebbly sandstones containing clasts of mudstone, andesite, and detritus from Precambrian and Mesozoic sources in the Brazos-San Luis uplift to the east and northeast. by the end of Animas deposition, the San Juan sag (then a northeastern extension of the San Juan basin) was a broad, southwest-plunging synclinal downwarp bounded by hogback monoclines to the north and east. An erosional period followed Animas deposition; the greatest thickness of Animas was preserved along the axis of this synclinal feature. Bright-red sandy mudstones and yellow-gray pebbly sandstones and cobble conglomerates comprise the proximal alluvial-fan deposits of the Blanco Basin Formation. They unconformably overlie Precambrian through Paleocene rocks and clast compositions reflect these sources. Renewed uplift and segmentation of the Brazos-San Luis uplift resulted in the shedding of detritus southwestward into the San Juan sag and eastward into a narrow, asymmetrical, north-trending wrench basin within the uplift. Following Blanco Basin deposition, the last Laramide event is represented by the separation of the San Juan sag from the San Juan basin by uplift of the Archuleta anticlinorium.

  18. Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    NASA Astrophysics Data System (ADS)

    Rouan, D.; Parviainen, H.; Moutou, C.; Deleuil, M.; Fridlund, M.; Ofir, A.; Havel, M.; Aigrain, S.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cabrera, J.; Cavarroc, C.; Csizmadia, Sz.; Deeg, H. J.; Diaz, R. F.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Gandolfi, D.; Gillon, M.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Samuel, B.; Santerne, A.; Schneider, J.; Tingley, B.; Wuchterl, G.

    2012-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search for possible background eclipsing binaries conducted at CFHT and OGS concluded with a very low risk of false positives. The usual techniques of combining RV and transit data simultaneously were used to derive stellar and planetary parameters. The planet has a mass of Mp = 2.8 ± 0.3 MJup, a radius of Rpl= 1.05 ± 0.13RJup, a density of ≈ 3 g cm-3. RV data also clearly reveal a nonzero eccentricity of e = 0.16 ± 0.02. The planet orbits a mature G0 main sequence star of V = 15.5 mag, with a mass M⋆ = 1.14 ± 0.08 M⊙, a radius R ⋆ = 1. 61 ± 0.18 R⊙ and quasi-solarabundances. The age of the system is evaluated to be 7 Gyr, not far from the transition to subgiant, in agreement with the rather large stellar radius. The two features of a significant eccentricity of the orbit and of a fairly high density are fairly uncommon for a hot Jupiter. The high density is, however, consistent with a model of contraction of a planet at this mass, given the age of the system. On the other hand, at such an age, circularization is expected to be completed. In fact, we show that for this planetary mass and orbital distance, any initial eccentricity should not totally vanish after 7 Gyr, as long as the tidal quality factor Qp is more than a few 105, a value that is the lower bound of the usually expected range. Even if CoRoT-23b features a density and an eccentricity that are atypical of a hot Jupiter, it is thus not an enigmatic object. The CoRoT space mission, launched on 27 December 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. First CoRoT data are available to the public from the CoRoT archive: http

  19. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

    SciTech Connect

    Espinosa, Alexander; Oke, Vilija; Elfving, Ase; Nyberg, Filippa; Covacu, Ruxandra; Wahren-Herlenius, Marie

    2008-12-10

    Patients with the systemic autoimmune diseases Sjoegrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1. While Ro52 and UBE2D1 are cytoplasmic proteins, UBE2E1 is localized to the nucleus. Here, we investigate how domains of human Ro52 regulate its intracellular localization. By expressing fluorescently labeled Ro52 and Ro52 mutants in HeLa cells, an intact coiled-coil domain was found to be necessary for the cytoplasmic localization of Ro52. The amino acids 381-470 of the B30.2 region were essential for translocation into the nucleus. Furthermore, after exposure of HeLa cells to the inflammatory mediator nitric oxide (NO), Ro52 translocated to the nucleus. A nuclear localization of Ro52 in inflamed tissue expressing inducible NO synthetase (iNOS) from cutaneous lupus patients was observed by immunohistochemistry and verified in NO-treated cultures of patient-derived primary keratinocytes. Our results show that the localization of Ro52 is regulated by endogenous sequences, and that nuclear translocation is induced by an inflammatory mediator. This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus.

  20. [The medical world of Juan Gil de Zamora's Historia Naturalis (ca. 1275-1296)].

    PubMed

    García Ballester, L; Domínguez, A

    1994-01-01

    The article describes the authors and works which were quoted by the Franciscan Juan Gil de Zamora in his Historia naturalis, a scientific encyclopaedia written between c. 1275 and before 1296, probably in the Franciscan monastery of Zamora (Kingdom of Castille). Juan Gil made wide use of the Avicenna's Canon, Gilbertus de Aquila (Anglicus)'s Compendium medicine, and Salernitan medical literature. His work contributed to the diffusion of these medical authors and works throughout the Christian intellectual milieu of late medieval Castille. This diffusion was not without problems.

  1. The Problem of Longitude in the 18th Century: Jorge Juan, Antonio de Ulloa and the Expedition of the Paris Academy of Sciences to the Kingdom of Peru

    NASA Astrophysics Data System (ADS)

    Gutiérrez, Manuel Pérez

    2015-05-01

    Jorge Juan and Antonio de Ulloa, naval officers of the Spanish Navy in the Midshipmen's Royal Academy were appointed to take part in one of the most important scientific expeditions of the 18th century. The question of the shape of the Earth, of vital importance for navigation, was solved by the Paris Academy of Sciences by request of Louis XV of France in 1735. The aim was to determine the form of the ellipsoid that Newton had described in the 17th century for any spherical and homogeneous body in rotation about an axis. Two expeditions were prepared for the geodetic measures of meridian arc both in high latitudes (Lapland, Finland) and in the equatorial zone (the Kingdom of Peru); Pierre Louis Maupertuis took charge of the northern expedition whereas the second one was charged to La Condamine, along with Jorge Juan and Antonio de Ulloa. The results obtained by the Spaniards were gathered in a publication: Observaciones astronómicas y físicas hechas en los Reinos del Perú. In it, they dedicate a chapter to the determination of astronomic longitude with the only technology that was providing certain precision at the moment: the simultaneous observation of the same astronomic phenomenon in two different places. Specifically, they explain in detail in Book III: Las Observaciones de la Inmersiones y Emersiones de los satélites de Júpiter, como asimismo de los eclipses de Luna; de las cuales de deduce la Longitud de los Lugares, incluyendo las correcciones a efectuar por la variación de la declinación diaria del Sol.

  2. Tectonic and unroofing history of Neogene Manantiales foreland basin deposits, Cordillera Frontal (32°30'S), San Juan Province, Argentina

    NASA Astrophysics Data System (ADS)

    Pérez, Daniel J.

    2001-12-01

    The Miocene Manantiales foreland basin is located in Cordillera Frontal of San Juan, between 32°30' and 33°S. The unroofing study of the synorogenic Miocene deposits provides information about the structural evolution of Cordón de La Ramada fold-and-thrust belt. These Tertiary deposits are represented by the Chinches Formation and comprise seven members (Tc0-Tc6). They are the result of the uplift of Mesozoic sequences that crop out in La Ramada fold-and-thrust belt of the Cordillera Principal. Quaternary deposits unconformably overlying the Chinches Formation are composed of granitic and rhyolitic blocks, and represent the final uplift of the Cordón del Espinacito and a series of out-of-sequence thrusts. The unroofing studies also provide sufficient information to establish the out-of-sequence timing of the deformation at this latitude. Initial deposition of the Tertiary deposits can be dated at about 20 Ma, or early Miocene. Andesitic lavas dated in 9.2±0.3, 10.7±0.7, and 12.7±0.7 Ma unconformably overlie the structure of La Ramada fold-and-thrust belt. These facts constrain the uplift of the High Andes between 20 and 10 Ma at this latitude. The unconformity between Tertiary and Quaternary deposits suggests final uplift during Pliocene-Pleistocene times.

  3. Chronic ethanol administration increases the binding of sup 3 H Ro-15-4513 in primary cultured spinal cord neurons

    SciTech Connect

    Mlatre, M.; Ticku, M.K. )

    1989-02-09

    Ro 15-4513 (ethyl-8-azido-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo (1,5{alpha}), (1,4) benzodiazepine-3-carboxylate) is reported to be a selective ethanol antagonist in biochemical and behavioral studies. The effect of chronic ethanol treatment on the binding of ({sup 3}H)Ro 15-4513 was investigated in cultured spinal cord neurons, which are shown to possess all the elements of GABA benzodiazepine receptor complex. Chronic ethanol treatment (50 mM for 6 hr, 12 hr, 18 hr, 3 days, and 5{sub 3} days) produced an increase in the specific binding of ({sub 3}H)Ro 15-4513. The increase in binding in these neurons was due to an increase in the number (B{sub max}) of receptor sites. This effect was specific for Ro 15-4513, since identical ethanol treatment did not alter the binding of benzodiazepine antagonist ({sup 3}H)Ro 15-1788 or agonist ({sup 3}H)flunitrazepam or inverse agonist ({sup 3}H)methyl-{beta}-carboline-3-carboxylate. Similar results have been reported following chronic ethanol treatment to rats. These results suggest that the Ro 15-4513 binding sites on the oligomeric GABA receptor complex are altered following chronic ethanol administration, and support the notion of a unique role of Ro 15-4513 as an ethanol antagonist.

  4. Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys

    PubMed Central

    Zelenock, Kathy A.; Lindsey, Angela M.; Sulima, Agnieszka; Rice, Kenner C.; Prinssen, Eric P.; Wichmann, Jürgen; Woods, James H.

    2016-01-01

    Nociceptin/orphanin FQ receptor (NOP) agonists have been reported to produce antinociceptive effects in rhesus monkeys with comparable efficacy to μ-opioid receptor (MOP) agonists, but without their limiting side effects. There are also known to be species differences between rodents and nonhuman primates (NHPs) in the behavioral effects of NOP agonists. The aims of this study were the following: 1) to determine if the NOP agonist Ro 64-6198 could be trained as a discriminative stimulus; 2) to evaluate its pharmacological selectivity as a discriminative stimulus; and 3) to establish the order of potency with which Ro 64-6198 produces discriminative stimulus effects compared with analgesic effects in NHPs. Two groups of rhesus monkeys were trained to discriminate either fentanyl or Ro 64-6198 from vehicle. Four monkeys were trained in the warm-water tail-withdrawal procedure to measure antinociception. Ro 64-6198 produced discriminative stimulus effects that were blocked by the NOP antagonist J-113397 and not by naltrexone. The discriminative stimulus effects of Ro 64-6198 partially generalized to diazepam, but not to fentanyl, SNC 80, ketocyclazocine, buprenorphine, phencyclidine, or chlorpromazine. Fentanyl produced stimulus effects that were blocked by naltrexone and not by J-113397, and Ro 64-6198 did not produce fentanyl-appropriate responding in fentanyl-trained animals. In measures of antinociception, fentanyl, but not Ro 64-6198, produced dose-dependent increases in tail-withdrawal latency. Together, these results demonstrate that Ro 64-6198 produced stimulus effects in monkeys that are distinct from other opioid receptor agonists, but may be somewhat similar to diazepam. In contrast to previous findings, Ro 64-6198 did not produce antinociception in the majority of animals tested even at doses considerably greater than those that produced discriminative stimulus effects. PMID:26801398

  5. Improved variability classification of CoRoT targets with Giraffe spectra

    NASA Astrophysics Data System (ADS)

    Sarro, L. M.; Debosscher, J.; Neiner, C.; Bello-García, A.; González-Marcos, A.; Prendes-Gero, B.; Ordieres, J.; León, G.; Aerts, C.; de Batz, B.

    2013-02-01

    Aims: We present an improved method for automated stellar variability classification, using fundamental parameters derived from high resolution spectra, with the goal to improve the variability classification obtained using information derived from CoRoT light curves only. Although we focus on Giraffe spectra and CoRoT light curves in this work, the methods are much more widely applicable. Methods: In order to improve the variability classification obtained from the photometric time series, only rough estimates of the stellar physical parameters (Teff and log (g)) are needed because most variability types that overlap in the space of time series parameters, are well separated in the space of physical parameters (e.g. γ Dor/SPB or δ Sct/β Cep). In this work, several state-of-the-art machine learning techniques are combined to estimate these fundamental parameters from high resolution Giraffe spectra. Next, these parameters are used in a multi-stage Gaussian-Mixture classifier to perform an improved supervised variability classification of CoRoT light curves. The variability classifier can be used independently of the regression module that estimates the physical parameters, so that non-spectroscopic estimates derived e.g. from photometric colour indices can be used instead. Results: Teff and log (g) are derived from Giraffe spectra, for 6832 CoRoT targets. The use of those parameters in addition to information extracted from the CoRoT light curves, significantly improves the results of our previous automated stellar variability classification. Several new pulsating stars are identified with high confidence levels, including hot pulsators such as SPB and β Cep, and several γ Dor-δ Sct hybrids. From our samples of new γ Dor and δ Sct stars, we find strong indications that the instability domains for both types of pulsators are larger than previously thought. The CoRoT space mission, launched on 27 December 2006, has been developed and is operated by CNES, with

  6. [Dietary prescriptions for the elites of the kingdom of Navarre in the 16th century: the cases of Juan Rena and Juan de Alarcón].

    PubMed

    Serrano Larráyoz, Fernando

    2014-01-01

    The aim of this article is to present and analyse four dietary prescriptions from the 16th century prepared for Juan Rena, a cleric of Venetian origin, and his servant Juan de Alarcón, which are kept at the Archivo General de Navarra. These documents demonstrate the interest of the patients and physicians in dietetics, understood as a group of health and hygienic measures based on the Galenic res naturales and res non naturales. These four prescriptions are closely related to the ad personam or consilia health regimens, which represent a genre of medical literature whose significance in Renaissance Spain has received little attention. The cases studied reveal the high esteem in which the elites held the possession of therapeutic resources adapted to their individual needs, which were compiled and copied for personal use.

  7. PCR amplification of RoTat 1.2 VSG gene in Trypanosoma evansi isolates in Kenya.

    PubMed

    Ngaira, J M; Njagi, E N M; Ngeranwa, J J N; Olembo, N K

    2004-02-26

    A direct card agglutination test for Trypanosoma evansi, CATT/T. evansi based on the predominant variable antigen-type (pVAT) RoTat 1.2 was evaluated previously in the field in Isiolo District, Kenya. Sixteen out of 51 (31.4%) parasitologically positive camels were negative by the antibody detection test. In the present study, trypanosomes isolated from the camels were analysed in an attempt to determine the cause of the false negative results of CATT/T. evansi. A total of 20 field isolates comprised 16 stocks from camels that were negative by CATT/T. evansi, and 4 from CATT/T. evansi-positive camels. In addition, 15 known T. evansi and four T. brucei were used as reference. Purified DNA samples were tested using an established RoTat 1.2-based polymerase chain reaction (PCR) that yields a 488 bp product for the specific detection of T. evansi. Antibodies to RoTat 1.2 variant surface glycoprotein (VSG) were used in Western blotting to detect RoTat 1.2 VSG linear epitopes. Results of PCR and Western blot showed that the 16 stocks isolated from CATT/T. evansi-negative camels fell into three groups. In Group 1, both the RoTat 1.2 VSG gene and the VSG were absent in three stocks. In five trypanosome stocks in Group 2, the RoTat 1.2 VSG gene was detected, but Western blot was negative indicating absence of the expressed VSG. Five other stocks containing the RoTat 1.2 VSG gene were also in this group. The RoTat 1.2 VSG gene was detected and Western blot was positive in all four trypanosome stocks in Group 3. All four stocks from CATT/T. evansi-positive camels contained the RoTat 1.2 VSG gene and the expressed VSG. The reference T. evansi KETRI 2479 lacked the RoTat 1.2 VSG gene and there was no immune reactivity detected by Western blot. The rest of the reference T. evansi stocks examined contained the RoTat 1.2 VSG gene. All the four T. brucei samples examined were negative by PCR and Western blot. In conclusion, this study showed that the RoTat 1.2 VSG gene was absent

  8. Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital

    SciTech Connect

    Hoffman, P.L.; Tabakoff, B.; Szabo, G.; Suzdak, P.D.; Paul, S.M.

    1987-08-03

    The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the incoordinating effect of ethanol in mice, as measured on an accelerating Rotarod. This effect was blocked by benzodiazepine receptor antagonists. In contrast, Ro15-4513 had no effect on ethanol-induced hypothermia in mice. However, Ro15-4513 reversed the hypothermic effect of pentobarbital, and, at higher dose, also reversed the incoordinating effect of pentobarbital in mice. The data support the hypothesis that certain of the pharmacological effects of ethanol are mediated by actions at the GABA-benzodiazepine receptor-coupled chloride channel. 35 references, 2 figures.

  9. Understanding nuclear motions in molecules: Derivation of Eckart frame ro-vibrational Hamiltonian operators via a gateway Hamiltonian operator

    SciTech Connect

    Szalay, Viktor

    2015-05-07

    A new ro-vibrational Hamiltonian operator, named gateway Hamiltonian operator, with exact kinetic energy term, T-hat, is presented. It is in the Eckart frame and it is of the same form as Watson’s normal coordinate Hamiltonian. However, the vibrational coordinates employed are not normal coordinates. The new Hamiltonian is shown to provide easy access to Eckart frame ro-vibrational Hamiltonians with exact T-hat given in terms of any desired set of vibrational coordinates. A general expression of the Eckart frame ro-vibrational Hamiltonian operator is given and some of its properties are discussed.

  10. Holocene compression in the Acequión valley (Andes Precordillera, San Juan province, Argentina): Geomorphic, tectonic, and paleoseismic evidence

    NASA Astrophysics Data System (ADS)

    Audemard, M.; Franck, A.; Perucca, L.; Laura, P.; Pantano, Ana; Avila, Carlos R.; Onorato, M. Romina; Vargas, Horacio N.; Alvarado, Patricia; Viete, Hewart

    2016-04-01

    The Matagusanos-Maradona-Acequión Valley sits within the Andes Precordillera fold-thrust belt of western Argentina. It is an elongated topographic depression bounded by the roughly N-S trending Precordillera Central and Oriental in the San Juan Province. Moreover, it is not a piggy-back basin as we could have expected between two ranges belonging to a fold-thrust belt, but a very active tectonic corridor coinciding with a thick-skinned triangular zone, squeezed between two different tectonic domains. The two domains converge, where the Precordillera Oriental has been incorporated to the Sierras Pampeanas province, becoming the western leading edge of the west-verging broken foreland Sierras Pampeanas domain. This latter province has been in turn incorporated into the active deformation framework of the Andes back-arc at these latitudes as a result of enhanced coupling between the converging plates due to the subduction of the Juan Fernández ridge that flattens the Nazca slab under the South American continent. This study focuses on the neotectonics of the southern tip of this N-S elongated depression, known as Acequión (from the homonym river that crosses the area), between the Del Agua and Los Pozos rivers. This depression dies out against the transversely oriented Precordillera Sur, which exhibits a similar tectonic style as Precordillera Occidental and Central (east-verging fold-thrust belt). This contribution brings supporting evidence of the ongoing deformation during the Late Pleistocene and Holocene of the triangular zone bounded between the two leading and converging edges of Precordillera Central and Oriental thrust fronts, recorded in a multi-episodic lake sequence of the Acequión and Nikes rivers. The herein gathered evidence comprise Late Pleistocene-Holocene landforms of active thrusting, fault kinematics (micro-tectonic) data and outcrop-scale (meso-tectonic) faulting and folding of recent lake and alluvial sequences. In addition, seismically

  11. BEER analysis of Kepler and CoRoT light curves. III. Spectroscopic confirmation of seventy new beaming binaries discovered in CoRoT light curves

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Faigler, S.; Mazeh, T.

    2015-08-01

    Context. The BEER algorithm searches stellar light curves for the BEaming, Ellipsoidal, and Reflection photometric modulations that are caused by a short-period companion. These three effects are typically of very low amplitude and can mainly be detected in light curves from space-based photometers. Unlike eclipsing binaries, these effects are not limited to edge-on inclinations. Aims: Applying the algorithm to wide-field photometric surveys such as CoRoT and Kepler offers an opportunity to better understand the statistical properties of short-period binaries. It also widens the window for detecting intrinsically rare systems, such as short-period brown-dwarf and massive-planetary companions to main-sequence stars. Methods: Applying the search to the first five long-run center CoRoT fields, we identified 481 non-eclipsing candidates with periodic flux amplitudes of 0.5-87 mmag. Optimizing the Anglo-Australian-Telescope pointing coordinates and the AAOmega fiber-allocations with dedicated softwares, we acquired six spectra for 231 candidates and seven spectra for another 50 candidates in a seven-night campaign. Analysis of the red-arm AAOmega spectra, which covered the range of 8342-8842 Å, yielded a radial-velocity precision of ~1 km s-1. Spectra containing lines of more than one star were analyzed with the two-dimensional correlation algorithm TODCOR. Results: The measured radial velocities confirmed the binarity of seventy of the BEER candidates - 45 single-line binaries, 18 double-line binaries, and 7 diluted binaries. We show that red giants introduce a major source of false candidates and demonstrate a way to improve BEER's performance in extracting higher fidelity samples from future searches of CoRoT light curves. The periods of the confirmed binaries span a range of 0.3-10 days and show a rise in the number of binaries per ΔlogP toward longer periods. The estimated mass ratios of the double-line binaries and the mass ratios assigned to the single

  12. Arrachements des épines iliaques antéro-supérieures et antéro-inférieures chez l'adolescent sportifs: à propos de deux cas

    PubMed Central

    Louaste, Jamal; Cherrad, Taoufik; Rachid, Khalid

    2015-01-01

    Les arrachements des épines iliaques antéro-supérieures et antéro-inférieures sont des entités rares qui touchent surtout l'enfant et l'adolescent. Elles se voient généralement lors d'une activité sportive. Le tableau clinique est dominé par une douleur brutale et importante de la hanche de type mécanique. Alors que le diagnostic est confirmé par les examens radiologiques. Nous rapportons deux cas de fractures arrachement des épines iliaques l'une antéro-supérieure et l'autre antéro-inférieure. PMID:26985274

  13. Side band suppression for wide band optical RoF systems

    NASA Astrophysics Data System (ADS)

    Abir, Hraghi; Ben Abid, Samir; Menif, Mourad

    2015-05-01

    In this paper, we propose a flexible monocycle generator that is based on multi-tonal excitation of a dual-arm MZM. The proposed generator permits the generation of different waveforms, such as Gaussian, first order Gaussian derivative, sinusoidal, cosine and sinc pulses. We exploit the proposed generator in order to generate the International Telecommunication Union-Radiocommunication( ITU-R) recommended channelization which contains four carrier frequencies, spaced by 2.16 GHz (58.32 GHz, 60.48 GHz, 62.64 GHz and 64.80 GHz). This millimeter waves (mmwaves) have attracted a great deal of attention in the Radio over Fiber (RoF) systems. The main challenge of the RoF system is to provide higher bands and increase significantly data rate with using millimeter-wave (mm-wave) band.

  14. Magnetic order on a frustrated lattice due to orbital degrees of freedom in RO2 hyperoxides

    NASA Astrophysics Data System (ADS)

    Oleś, Andrzej M.; Wohlfeld, Krzysztof; Daghofer, Maria

    2012-02-01

    The alkali RO2 hyperoxides (R=Rb,Cs,K) crystallize in a frustrated bct lattice. Nevertheless, all of the members of the family of alkali RO2 hyperoxides have long range layered C-type antiferromagnetic (C-AF) order at low temperature. We show that including the almost degenerate p-orbital degrees of freedom in a realistic spin-orbital model can resolve this contradiction [1]. Although a priori the orbital degrees of freedom do not remove frustration in spin system, we show that the anomalously large interorbital hopping together with the orbital order induced by the lattice stabilize the C-AF order in this class of compounds, in agreement with generalized Goodenough-Kanamori rules formulated here. [4pt] [1] K. Wohlfeld, M. Daghofer, and A.M. Ole's, EPL 96, 27001 (2011).

  15. Aspects of the Eckart frame ro-vibrational kinetic energy operator

    NASA Astrophysics Data System (ADS)

    Szalay, Viktor

    2015-08-01

    A most decisive part of developing the Eckart frame ro-vibrational kinetic energy operator (KEO) in terms of curvilinear internal coordinates is the introduction of vibrational displacements obeying the Eckart conditions. It is examined here, how such displacements may be constructed by orthogonal and nonorthogonal transformations, and how they can be employed in developing the KEO. In particular, it is shown analytically, by term by term comparison, that the Eckart KEOs obtained by employing Pickett's method and the gateway Hamiltonian method are equivalent. That is, although it may appear in the form of very different expressions, the general, exact ro-vibrational Eckart frame KEO is unique. As side result, it has been shown that the simple formula of the pseudo-potential derived by Watson for the exact KEO given in normal coordinates applies to any Eckart frame KEO, irrespective of the choice of the vibrational coordinates.

  16. Simple and reconfigured single-sideband OFDM RoF system.

    PubMed

    Xu, Yuming; Li, Xinying; Yu, Jianjun; Chang, Gee-Kung

    2016-10-03

    We propose a simple and reconfigured dispersion-tolerant single sideband (SSB) orthogonal frequency division multiplexing (OFDM) radio over fiber (RoF) system enabled by digital signal processing (DSP), one in-phase/quadrature (I/Q) modulator and direct-detection. The generated radio frequency (RF) is based on DSP and the frequency can be flexibly adjusted, which can be employed in the future software-defined radio access network (RAN). Based on our proposed system, we have experimentally demonstrated 16-ary quadrature amplitude modulation (16QAM) 21.87-Gb/s 21-GHz and 38-GHz SSB-OFDM RoF signal generation and transmission over 80-km single-mode fiber (SMF), respectively.

  17. Stellar parameters for stars of the CoRoT exoplanet field

    NASA Astrophysics Data System (ADS)

    Cortés, C.; Maciel, S. C.; Vieira, S.; Ferreira Lopes, C. E.; Leão, I. C.; de Oliveira, G. P.; Correia, C.; Canto Martins, B. L.; Catelan, M.; De Medeiros, J. R.

    2015-09-01

    Context. Spectroscopic observations represent a fundamental step in the physical characterization of stars and, in particular, in the precise location of stars in the HR diagram. Rotation is also a key parameter, impacting stellar properties and evolution, which modulates the interior and manifests itself on the surface of stars. To date, the lack of analysis based on large samples has prevented our understanding of the real impact of stellar parameters and rotation on the stellar evolution as well as on the behavior of surface abundances. The space missions, CoRoT and Kepler, are providing us with rotation periods for thousands of stars, thus enabling a robust assessment of the behavior of rotation for different populations and evolutionary stages. For these reasons, the follow-up programs are fundamental to increasing the returns of these space missions. An analysis that combines spectroscopic data and rotation/modulation periods obtained from these space missions provides the basis for establishing the evolutionary behavior of the angular momentum of solar-like stars at different evolutionary stages, and the relation of rotation with other relevant physical and chemical parameters. Aims: To support the computation and evolutionary interpretation of periods associated with the rotational modulation, oscillations, and variability of stars located in the CoRoT fields, we are conducting a spectroscopic survey for stars located in the fields already observed by the satellite. These observations allow us to compute physical and chemical parameters for our stellar sample. Methods: Using spectroscopic observations obtained with UVES/VLT and Hydra/Blanco, and based on standard analysis techniques, we computed physical and chemical parameters (Teff, log (g), [Fe/H], vmic, vrad, vsin (i), and A(Li)) for a large sample of CoRoT targets. Results: We provide physical and chemical parameters for a sample comprised of 138 CoRoT targets. Our analysis shows the stars in our

  18. Membrane autopsy based bio-fouling investigation of distillery spent wash RO treatment plant.

    PubMed

    Sharma, Pinki; Joshi, Himanshu

    2014-01-01

    In this paper, a thorough investigation has been done to evaluate the effects of different pollutants on membrane performance by autopsy. Autopsy was performed on fresh and fouled reverse osmosis (RO) membrane elements from a distillery spent wash treatment plant by different analyses, such as field emission scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy and X-ray diffraction, to identify the cause of poor performance of an RO plant. Results obtained from the analysis of membranes indicate that a mixture of colloids and organic matters (polysaccharides and amines) along with the presence of multivalent ions (Ca, Mg, Fe and SO4) causes membrane fouling, which in turn affects membrane performance. Possible measures to improve treated effluent quality and mitigate fouling have been suggested for this particular case study.

  19. Thematic trip: "Save Roşia MontanÄă"

    NASA Astrophysics Data System (ADS)

    Eugenia, Marcu

    2015-04-01

    The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

  20. Preliminary data report for the San Juan Basin-Crownpoint surveillance study

    USGS Publications Warehouse

    Frenzel, Peter F.; Craigg, Steven D.; Padgett, Elizabeth T.

    1981-01-01

    Geohydrologic data that may be used to predict the effects of mining on Navajo water resources in the San Juan structural basin are reported as well as the current availability of data from other government agencies. Emphasis is on the vicinity of Crownpoint, New Mexico. (USGS)

  1. 77 FR 33239 - Prairie Stewardship Plan/Environmental Impact Statement, San Juan Island National Historical Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... National Park Service Prairie Stewardship Plan/Environmental Impact Statement, San Juan Island National Historical Park AGENCY: National Park Service, Interior. ACTION: Notice of Intent to Prepare an Environmental... Park Service (NPS) is initiating the preparation of an Environmental Impact Statement (EIS) for...

  2. Juan Rulfo and Machado de Assis: Toward an Integrated New Narrative

    ERIC Educational Resources Information Center

    Wiseman, David P.; Krause, James R.

    2016-01-01

    Despite apparent connections between Brazilian and Spanish American narratives, comparative scholarship has only recently begun to investigate actively these important points of contact. In this study, we introduce a vital crossover between the two traditions, involving Juan Rulfo and Joaquim Maria Machado de Assis. Rulfo's outspoken affinity for…

  3. San Juan School Evaluation. Research and Evaluation Report Series No. 27.

    ERIC Educational Resources Information Center

    Bureau of Indian Affairs (Dept. of Interior), Albuquerque, NM.

    The San Juan School (Espanola, New Mexico) was evaluated by a team from the Bureau of Indian Affairs' Central Office staff in Albuquerque. Team members assisted the Division of Program Review as representatives from other divisions, using the expertise in their respective fields. The methodology and techniques, which were left to the evaluator's…

  4. Seismic Anisotropy below the Juan De Fuca Plate: Results from the Cascadia Initiative

    NASA Astrophysics Data System (ADS)

    Martin-Short, R.; Allen, R. M.; Bastow, I. D.

    2014-12-01

    Investigation of seismic anisotropy using shear wave splitting is typically used to infer information about asthenospheric flow geometry. In order to understand how such flow varies below the Juan de Fuca plate and is affected by its subduction along the Cascadia forearc, stacked splitting results are determined for 90 offshore and 27 onshore broadband seismometers. These instruments were deployed as part of phases one and two of the Cascadia Initiative, which is an ongoing effort to understand tectonic processes in the Pacific Northwest. The onshore results conform to those of previous studies, suggesting a uniformly trench-perpendicular flow field and thus implying a thick layer of material entrained beneath the slab. The offshore results offer suggestions about how the orientation of asthenospheric flow evolves across the width of the Juan de Fuca plate, and are unique in that they document variation in anisotropy from the ridge to the trench. The results indicate ridge-perpendicular flow geometry close to the Juan de Fuca ridge, which appears to rotate towards the direction of absolute plate motion as one moves towards the trench. As suggested by the latest tomographic images the subducting Juan de Fuca plate is segmented, with 'gaps' between the segments. These gaps may act as channels for the flow of mantle material.

  5. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    ERIC Educational Resources Information Center

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  6. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... yards around all cruise ships entering, departing, moored or anchored in the Port of San Juan, Puerto Rico. The security zone for a cruise ship entering port is activated when the vessel is one mile north... scheduled arrivals and departures of cruise ships via a broadcast notice to mariners. (c) Definition....

  7. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... yards around all cruise ships entering, departing, moored or anchored in the Port of San Juan, Puerto Rico. The security zone for a cruise ship entering port is activated when the vessel is one mile north... scheduled arrivals and departures of cruise ships via a broadcast notice to mariners. (c) Definition....

  8. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... yards around all cruise ships entering, departing, moored or anchored in the Port of San Juan, Puerto Rico. The security zone for a cruise ship entering port is activated when the vessel is one mile north... scheduled arrivals and departures of cruise ships via a broadcast notice to mariners. (c) Definition....

  9. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... yards around all cruise ships entering, departing, moored or anchored in the Port of San Juan, Puerto Rico. The security zone for a cruise ship entering port is activated when the vessel is one mile north... scheduled arrivals and departures of cruise ships via a broadcast notice to mariners. (c) Definition....

  10. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... yards around all cruise ships entering, departing, moored or anchored in the Port of San Juan, Puerto Rico. The security zone for a cruise ship entering port is activated when the vessel is one mile north... scheduled arrivals and departures of cruise ships via a broadcast notice to mariners. (c) Definition....

  11. Mediated Debate, Historical Framing, and Public Art: The Juan de Onate Controversy in El Paso

    ERIC Educational Resources Information Center

    Perez, Frank G.; Ortega, Carlos F.

    2008-01-01

    In 1988, the El Paso, Texas, city council accepted a proposal to build twelve statues of historically important individuals as part of a downtown revitalization initiative. Juan de Onate was selected as the centerpiece statue of the XII Travelers Memorial of the Southwest. The decision to honor the Spanish colonizer triggered a local controversy…

  12. 77 FR 52310 - Expansion of Foreign-Trade Zone 61, San Juan, Puerto Rico

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 61, San Juan, Puerto Rico Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the...

  13. U.S. EPA Statement on San Juan River Data from Gold King Mine Release

    EPA Pesticide Factsheets

    SHIPROCK, NEW MEXICO - Today, U.S. EPA released additional water quality data from Aug. 7 to Aug. 9, 2015, on the San Juan River between Farmington and Shiprock, New Mexico. The August 7 data was collected for baseline purposes to understand river c

  14. 77 FR 61632 - Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan Island National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... terminates on the southeastern tip of San Juan Island, is threatened by coastal erosion at the base of the... from further consideration (including armoring the base of the slope in lieu of road realignment.... Since measurements began in 2002, erosion has moved approximately 14 feet closer to the guard rail...

  15. San Juan, Puerto Rico Agrees to Make Investments in Clean Water

    EPA Pesticide Factsheets

    (New York, N.Y.) Under a settlement with the U.S. Department of Justice and the U.S. Environmental Protection Agency, the Municipality of San Juan has agreed to make substantial upgrades to its storm sewer systems throughout the city. The upgrades and rela

  16. Detection of new pulsations in the roAp star HD 177765

    NASA Astrophysics Data System (ADS)

    Holdsworth, Daniel L.

    2016-10-01

    We report the discovery of 2 previously undetected pulsation frequencies in the known roAp star HD 177765. Photometric observations by the Kepler space telescope during K2 Campaign 7 show low-amplitude pulsations (4-11 micro mag) previously unseen in photometry. We show the pulsations to be stable over the observation period, and demonstrate that the separation of the frequencies is not representative of the large frequency separation quantity needed to perform asteroseismic analysis.

  17. Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

    SciTech Connect

    Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.

    1989-04-01

    The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone.

  18. VizieR Online Data Catalog: CoRoT 105906206 frequencies analysis (da Silva+, 2014)

    NASA Astrophysics Data System (ADS)

    da Silva, R.; Maceroni, C.; Gandolfi, D.; Lehmann, H.; Hatzes, A. P.

    2014-03-01

    The file frequenc.dat contains the table with 220 frequencies, amplitudes, and phases, together with their uncertainties, derived for the light curve of CoRoT 105906206 with pulsations only (after subtracting the best binary model). The uncertainties are the formal values computed using equations (4), (10), and (11) of Montgomery & O'Donoghue (1999DSSN...13...28M). (1 data file).

  19. Exploring the Helium Core of the δ Scuti Star CoRoT 102749568 with Asteroseismology

    NASA Astrophysics Data System (ADS)

    Chen, Xinghao; Li, Yan; Lin, Guifang; Chen, Yanhui; Guo, Junjun

    2017-01-01

    Based on regularities in rotational splitting, we seek possible multiplets for the observed frequencies of CoRoT 102749568. There are 21 sets of multiplets identified, including four sets of multiplets with l = 1, nine sets of multiplets with l = 2, and eight sets of multiplets with l = 3. In particular, there are three complete triplets (f10, f12, f14), (f31, f34, f35), and (f41, f43, f44). The rotational period of CoRoT 102749568 is estimated to be {1.34}-0.05+0.04 days. When doing model fittings, three l = 1 modes (f12, f34, and f43) and the radial first overtone f13 are used. Our results shows that the three nonradial modes (f12, f34, and f43) are mixed modes, which mainly provide constraints on the helium core. The radial first overtone f13 mainly provides constraint on the stellar envelope. Hence the size of the helium core of CoRoT 102749568 is determined to be {M}{He} = 0.148 ± 0.003 M⊙ and {R}{He} = 0.0581 ± 0.0007 R⊙. The fundamental parameters of CoRoT 102749568 are determined to be M = 1.54 ± 0.03 M⊙, Z=0.006, {f}{ov}=0.004+/- 0.002, {log} g=3.696+/- 0.003, {T}{eff}=6886+/- 70 K, R = 2.916 ± 0.039 R⊙, and L = 17.12 ± 1.13 L⊙.

  20. Raman investigation of ro-vibrational modes of interstitial H2 in Si

    NASA Astrophysics Data System (ADS)

    Koch, S. G.; Lavrov, E. V.; Weber, J.

    2012-08-01

    A Raman scattering study of ro-vibrational transitions Q(J) of the interstitial H2 in Si is presented. It is shown that the Q(2) mode of para hydrogen is coupled to the TAX phonon of Si. The mode appears in the spectra at temperatures above 200 K. The results presented also suggest that the Q(3) transition of ortho hydrogen is resonantly coupled to the OΓ phonon.

  1. Benzodiazepine receptor binding in vivo with (/sup 3/)-Ro 15-1788

    SciTech Connect

    Goeders, N.E.; Kuhar, M.J.

    1985-07-29

    In vivo benzodiazepine receptor binding has generally been studied by ex vivo techniques. In this investigation, the authors identify the conditions where (/sup 3/H)-Ro 15-1788 labels benzodiazepine receptors by true in vivo binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. (/sup 3/H)-Flunitrazepam and (/sup 3/H)-clonazepam did not exhibit useful in vivo receptor binding. 39 references, 5 figures, 1 table.

  2. CoRoT observations of the young open cluster Dolidze 25

    NASA Astrophysics Data System (ADS)

    Ripepi, V.; Leccia, S.; Baglin, A.; Ruoppo, A.; Bernabei, S.; Zwintz, K.; Cusano, F.; Gandolfi, D.; Guenter, E. W.; Alencar, S.; Marconi, M.; Monteiro, M. J. P. F. G.; Palla, F.; Alcalá, J. M.; Boehm, T.; Catala, C.; Chavero, C.; Corradi, W. S.; Degl'Innocenti, S.; de La Reza, R.; Deluil, M.; Favata, F.; Fernandez, M.; Gregorio-Hetem, J.; Lepine, J. D. R.; Pinheiro, F. J. G.; Prada Moroni, P. G.; Quast, G.; Torres, C. A. O.; Weiss, W.

    2010-07-01

    We present some preliminary results based on the CoRoT observations of the young distant cluster Dolidze 25. The light curve for the 28 stars observed by the satellite have been analyzed and the relevant periodogram presented. As a result we have found two binary, three Pulsating Be, three SPB, two Spotted and one ellipsoidal variables. Noteworthy, we have also identified one PMS δ Scuti candidate.

  3. Antiscalant removal in accelerated desupersaturation of RO concentrate via chemically-enhanced seeded precipitation (CESP).

    PubMed

    McCool, Brian C; Rahardianto, Anditya; Cohen, Yoram

    2012-09-01

    An experimental study was carried out to demonstrate and quantify the feasibility of antiscalant (AS) removal from brackish water RO concentrate of high gypsum scaling propensity via lime treatment prior to seeded gypsum precipitation. Based on studies with model solutions, it was shown that sufficient AS removal (up to ∼90%) from RO concentrate is feasible via a lime treatment step (at a dose significantly lower than that required for conventional lime softening) to enable effective subsequent seeded gypsum precipitation. This two-step chemically-enhanced seeded precipitation (CESP) treatment of primary RO concentrate is suitable as an intermediate concentrate demineralization (ICD) stage for high recovery desalting employing secondary RO desalination. Analysis of gypsum precipitation and lime treatment kinetic data suggests that, after adequate CaCO(3) precipitation has been induced for effective AS scavenging, CaSO(4) desupersaturation can be achieved via seeded gypsum precipitation without retardation due to seed poisoning by AS. Also, the lime dose required to prevent seed poisoning during subsequent gypsum desupersaturation via seeded gypsum precipitation can be adequately assessed with a precipitation kinetics model that considers AS seed poisoning based on a Langmuir adsorption isotherm. The degree of AS removal after lime treatment increased linearly with the logarithm of the single lime dose additions. Staged lime dosing (i.e., multiple lime additions), however, removed a higher degree of AS relative to an equivalent single lime dose addition since a higher driving force for CaCO(3) precipitation could be maintained over the course of the lime treatment period.

  4. Growth conditions, compact perturbations and operator subdecomposability, with applications to generalized Cesàro operators

    NASA Astrophysics Data System (ADS)

    Miller, T. L.; Miller, V. G.; Neumann, M. M.

    2005-01-01

    We adapt recent results of Albrecht and Ricker to obtain conditions under which growth constraints on the left resolvent of a Banach space operator are preserved under suitable perturbations. As an application, we establish Bishop's property ([beta]) for certain generalized Cesàro operators on the classical Hardy spaces Hp, 1

  5. Learning to Improve E-mail Classification with numéro interactive

    NASA Astrophysics Data System (ADS)

    Jones, Dean M.

    This paper describes some of the ways in which we use artificial intelligence technologies in numéro interactive, a Customer Interaction Management system. In particular, we focus on the classification of e-mail messages into one of multiple business categories. We describe different features that are extracted from e-mail messages to help in this classification, and the improvement in the overall classification accuracy that results from the use of each kind of feature.

  6. Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR-RO.

    PubMed

    Dolar, Davor; Gros, Meritxell; Rodriguez-Mozaz, Sara; Moreno, Jordi; Comas, Joaquim; Rodriguez-Roda, Ignasi; Barceló, Damià

    2012-11-15

    The presence of emerging contaminants in the aquatic environment and their potential effects on living organisms has become an issue of growing concern. Among emerging contaminants, pharmaceuticals may enter the aquatic environment due to their high consumption and their incomplete removal in conventional municipal wastewater treatment plants (WWTPs). The main goal of this study was the assessment of the removal efficiency of pharmaceuticals found in municipal wastewater of a coastal WWTP (Castell-Platja d'Aro, Spain) using an integrated pilot scale membrane system (MBR-RO). Twenty multiple-class pharmaceuticals (including psychiatric drugs, macrolide antibiotics, β-blockers, sulfonamide and fluoroquinolone antibiotics, histamine H2 receptor antagonists, anti-inflammatories, nitroimidazole, β-agonist and antiplatelet agent) were measured in real influent with the lowest average concentration for psychiatric drugs (0.017 μg L(-1)) to the highest for macrolide antibiotics (2.02 μg L(-1)). Although some contaminants were in relatively high concentrations (even up to 2.90 μg L(-1) in the case of ofloxacin). The combination of MBR and RO treatment showed excellent overall removal of target emerging contaminants with removal rates above 99% for all of them. For some compounds (metronidazole, hydrocodone, codein, ranitidine) MBR provided high removal efficiency (up to 95%). Additionally RO membrane showed removal rates always higher than 99%.

  7. THE CoRoT DISCOVERY OF A UNIQUE TRIPLE-MODE CEPHEID IN THE GALAXY

    SciTech Connect

    Poretti, E.; Baglin, A.; Weiss, W. W.

    2014-11-10

    The exploitation of the CoRoT treasure of stars observed in the exoplanetary field allowed the detection of a unusual triple-mode Cepheid in the Milky Way, CoRoT 0223989566. The two modes with the largest amplitudes and a period ratio of 0.80 are identified with the first (P {sub 1} = 1.29 days) and second (P {sub 2} = 1.03 days) radial overtones. The third period, which has the smallest amplitude but is able to produce combination terms with the other two, is the longest one (P {sub 3} = 1.89 days). The ratio of 0.68 between the first-overtone period and the third period is the unusual feature. Its identification with the fundamental radial or a nonradial mode is discussed with respect to similar cases in the Magellanic Clouds. In both cases, the period triplet and the respective ratios make the star unique in our Galaxy. The distance derived from the period-luminosity relation and the galactic coordinates put CoRoT 0223989566 in the metal-rich environment of the ''outer arm'' of the Milky Way.

  8. Ro-vibrational excitation, alignment and orientation distributions of fast non-dissociatively scattered molecules

    NASA Astrophysics Data System (ADS)

    Harder, R.; Snowdon, K. J.

    1997-12-01

    The ro-vibrational distribution of fast diatomic molecules scattered from an uncorrugated surface under strongly dissipative glancing incidence conditions is calculated. The classical trajectory simulation includes potential surface switching associated with hot-electron scattering processes. Both ro-vibrational excitation and strong alignment of the classical angular momentum vector in the surface plane ("cartwheel motion") are observed, independent of the occurrence of potential surface switching. Ro-vibrational excitation is enhanced strongly by transitions between potential surfaces. The resultant larger proportion of molecules in highly rotationally excited states leads to a higher fraction of cartwheel-aligned molecules in the scattered molecule ensemble. The molecules which dissociate in the simulation are characterised by surface normal peaked internuclear axis orientation distributions. This is in agreement with the results of recent experiments [A. Nesbitt et al., Surf. Sci. 331-333 (1995) 321]. We observe, in addition, an enhanced rotational population of "topspin" oriented molecules, which arises from differences in the surface parallel oriented friction forces acting on each atom of the molecule. Glancing incidence scattering from well-prepared close-packed metal surfaces would appear to provide an efficient, general method to obtain a beam of preferentially aligned fast neutral diatomic molecules.

  9. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    NASA Astrophysics Data System (ADS)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  10. Threshold scaling limits of RO concentrates flowing in a long waste disposal pipeline.

    PubMed

    Semiat, R; Hasson, D; Zelmanov, G; Hemo, I

    2004-01-01

    Disposal of RO concentrates emanating from inland brackish water desalination plants presents a difficult environmental problem. The solution adopted by Mekorot--the National Water Company of Israel--is to construct a 30 km waste disposal pipeline for collecting concentrates emanating from several RO desalination plants and discharging them into the sea. The discharged concentrates are highly supersaturated with respect to CaCO3. Scale precipitation during concentrate flow through the RO module is inhibited by the presence of anti-scalants. The retention time of the concentrate solution in the discharge pipe will exceed 100 hours. This raises the issue of the risk of scale precipitation in the discharge pipe that could impair its proper functioning. The aim of the present study was to provide data for guiding the design and operation of the disposal pipeline. The extent of the induction period prior to the onset of precipitation was measured in a pilot plant simulating flow of concentrate solutions dosed with anti-scalants. The parameters investigated were the scaling potential, the anti-scalant concentration and the presence of a mixture of several anti-scalants. The results of this study provide threshold scaling limits under various conditions.

  11. [Demographic profile of Boróro Indians from Mato Grosso State, Brazil, 1993-1996].

    PubMed

    Souza, Luciene Guimarães de; Pagliaro, Heloisa; Santos, Ricardo Ventura

    2009-02-01

    This paper analyzes the demographic profile of the Boróro Indians from Mato Grosso State, Brazil, from 1993 to 1996. Data came from annual collection and registration of vital statistics conducted by the health service in three villages (Garças, Meruri, and Morada dos Boróro). The average annual population growth rate was 2.4%. Nearly half (44%) of the population was younger than 15 years (median 16 years). The crude birth rate was 30.9 per 1,000 and the crude death rate 7.3 per 1,000 inhabitants. The infant mortality rate was high (58.8 per thousand live births), probably resulting from precarious health conditions in the villages. The results showed that women married younger than men and that there were numerous unmarried adult men (26.7%) and women (13.3%), as compared to data from other indigenous groups. The total fertility rate of Boróro women was 4.3, quite low compared to other indigenous communities in Brazil. The study emphasizes the importance of systematically collecting and analyzing demographic data on indigenous populations.

  12. On Cesàro Limit Distribution of a Class of Permutative Cellular Automata

    NASA Astrophysics Data System (ADS)

    Maass, Alejandro; Martinez, Servet

    1998-01-01

    We study Cesàro means (time averages) of the evolution measures of the class of permutative cellular automata over {0, 1}ℕ defined by (\\varphi _B x)_n = x_{n{kern 1pt} {kern 1pt} + {kern 1pt} {kern 1pt} R} + Pi _{j{kern 1pt} {kern 1pt} = {kern 1pt} {kern 1pt} 0}^{R{kern 1pt} {kern 1pt} - {kern 1pt} {kern 1pt} 1} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} (1 + b_j + x_{n{kern 1pt} {kern 1pt} + {kern 1pt} {kern 1pt} j} ) where B= b 0 ⋯ b R-1is an aperiodic block in {0, 1} R and operations are taken mod 2. If the initial measure is Bernoulli, we prove that the limit of the Cesàro mean of the first column distribution exists. When R = 1 and B = 1, φ B is the mod 2 sum automaton. For this automaton we show that the limit is the (1/2, 1/2(-Bernoulli measure, and if the initial measure is Markov, we show that the limit of Cesàro mean of the one-site distribution is equidistributed.

  13. Tropical temperature variability and Kelvin-wave activity in the UTLS from GPS RO measurements

    NASA Astrophysics Data System (ADS)

    Scherllin-Pirscher, Barbara; Randel, William J.; Kim, Joowan

    2017-01-01

    Tropical temperature variability over 10-30 km and associated Kelvin-wave activity are investigated using GPS radio occultation (RO) data from January 2002 to December 2014. RO data are a powerful tool for quantifying tropical temperature oscillations with short vertical wavelengths due to their high vertical resolution and high accuracy and precision. Gridded temperatures from GPS RO show the strongest variability in the tropical tropopause region (on average 3 K2). Large-scale zonal variability is dominated by transient sub-seasonal waves (2 K2), and about half of sub-seasonal variance is explained by eastward-traveling Kelvin waves with periods of 4 to 30 days (1 K2). Quasi-stationary waves associated with the annual cycle and interannual variability contribute about a third (1 K2) to total resolved zonal variance. Sub-seasonal waves, including Kelvin waves, are highly transient in time. Above 20 km, Kelvin waves are strongly modulated by the quasi-biennial oscillation (QBO) in stratospheric zonal winds, with enhanced wave activity during the westerly shear phase of the QBO. In the tropical tropopause region, however, peaks of Kelvin-wave activity are irregularly distributed in time. Several peaks coincide with maxima of zonal variance in tropospheric deep convection, but other episodes are not evidently related. Further investigations of convective forcing and atmospheric background conditions are needed to better understand variability near the tropopause.

  14. RoCoMAR: robots' controllable mobility aided routing and relay architecture for mobile sensor networks.

    PubMed

    Le, Duc Van; Oh, Hoon; Yoon, Seokhoon

    2013-07-05

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

  15. Stratigraphic relationships of Cretaceous and early Tertiary rocks of a part of northwestern San Juan basin

    USGS Publications Warehouse

    Baltz, Elmer Harold

    1953-01-01

    The Bridge Timber Mountain area in south-central La Plata County, southwestern Colorado lies mostly in the northwestern part of the Central San Juan Basin but contains a segment of the bounding Hogback 'monocline' and Four-Corners platform. The area contains rocks of late Cretaceous through early Eocene age, as well as Pliocene, Pleistocene, and Recent terrace and pediment gravels. The Pictured Cliffs sandstone of late Montana age is the latest marine formation present. Retreat of the Cretaceous seas from the area marked the beginning of Laramide orogenic activity and the earliest stages of deformation which produced the modern San Juan Basin. The Fruitland formation and Kirtland shale were deposited in brackish water and on coastal plains left by the retreating Cretaceous sea. Beds of the Farmington sandstone member and upper shale member of the Kirtland shale show evidence of a new source of sediments to the north or northeast distinct from the southwestern source area of older Cretaceous rocks. The McDermott 'formation', composed mainly of volcanic debris, is considered to be a local lower member of the Animas formation. Beds of the upper member of the Animas formation of Cretaceous and Paleocene age are considered to extend entirely across the area and into New Mexico. Overstep of higher sandstone and shale beds of the upper member across lower conglomeratic beds shows that folding on the Hogback 'monocline' began during deposition of the upper member. Beds of the upper member of the Animas formation grade laterally southward into Paleocene beds of the Nacimiento formation, but upper Nacimiento beds overstep folded beds of the Animas formation on the Hogback 'monocline' at the north end of Bridge Timber Mountain. The San Jose formation of Paleocene and Eocene age is conformable with the Nacimiento formation except at the north end of Bridge Timber Mountain where upper San Jose beds overstep all older tilted beds down to the Fruitland formation. The heavy

  16. Pre-Clinical studies of Notch Signaling Inhibitor RO4929097 in Inflammatory Breast Cancer Cells

    PubMed Central

    Debeb, Bisrat G.; Cohen, Evan N.; Boley, Kimberly; Freiter, Erik M.; Li, Li; Robertson, Fredika M.; Reuben, James M.; Cristofanilli, Massimo; Buchholz, Thomas A.; Woodward, Wendy A.

    2015-01-01

    Basal breast cancer, common among patients presenting with inflammatory breast cancer, has been shown to be resistant to radiation and enriched in cancer stem cells. The Notch pathway plays an important role in self-renewal of breast cancer stem cells and contributes to inflammatory signaling that promotes the breast cancer stem cell phenotype. Herein we inhibited Notch signaling using a gamma secretase inhibitor, RO4929097, in an in vitro model that enriches for cancer initiating cells (3D clonogenic assay) and conventional 2D clonogenic assay to compare the effect on radiosensitization of the SUM149 and SUM190 inflammatory breast cancer (IBC) cell lines. RO4929097 downregulated the Notch target genes Hes1, Hey1 and HeyL and showed a significant reduction in anchorage independent growth in SUM190 and SUM149. However, the putative self-renewal assay mammosphere formation efficiency was increased with the drug. To assess radiosensitization of putative cancer stem cells, cells were exposed to increasing doses of radiation with or without 1uM RO4929097 in their standard (2D) and self-renewal enriching (3D) culture conditions. In the conventional 2D clonogenic assay, RO4929097 significantly sensitized SUM190 cells to ionizing radiation and has a modest radiosensitization effect in SUM149 cells. In the 3D clonogenic assays, however, a radioprotective effect was seen in both SUM149 and SUM190 cells at higher doses. Both cell lines express IL-6 and IL-8, cytokines known to mediate the efficacy of notch inhibition and to promote self-renewal of stem cells. We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-α, a potential mediator of IL-6 and IL-8 production in the microenvironment. These data suggest additional targeting agents may be required to selectively target IBC stem cells through notch inhibition, and that evaluation of microenvironmental influences may shed further light on the potential effects of this

  17. Galactic archaeology with asteroseismology and spectroscopy: Red giants observed by CoRoT and APOGEE

    NASA Astrophysics Data System (ADS)

    Anders, F.; Chiappini, C.; Rodrigues, T. S.; Miglio, A.; Montalbán, J.; Mosser, B.; Girardi, L.; Valentini, M.; Noels, A.; Morel, T.; Johnson, J. A.; Schultheis, M.; Baudin, F.; de Assis Peralta, R.; Hekker, S.; Themeßl, N.; Kallinger, T.; García, R. A.; Mathur, S.; Baglin, A.; Santiago, B. X.; Martig, M.; Minchev, I.; Steinmetz, M.; da Costa, L. N.; Maia, M. A. G.; Allende Prieto, C.; Cunha, K.; Beers, T. C.; Epstein, C.; García Pérez, A. E.; García-Hernández, D. A.; Harding, P.; Holtzman, J.; Majewski, S. R.; Mészáros, Sz.; Nidever, D.; Pan, K.; Pinsonneault, M.; Schiavon, R. P.; Schneider, D. P.; Shetrone, M. D.; Stassun, K.; Zamora, O.; Zasowski, G.

    2017-01-01

    With the advent of the space missions CoRoT and Kepler, it has recently become feasible to determine precise asteroseismic masses and relative ages for large samples of red giant stars. We present the CoRoGEE dataset, obtained from CoRoT light curves for 606 red giants in two fields of the Galactic disc that have been co-observed by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). We used the Bayesian parameter estimation code PARAM to calculate distances, extinctions, masses, and ages for these stars in a homogeneous analysis, resulting in relative statistical uncertainties of ≲2% in distance, 4% in radius, 9% in mass and 25% in age. We also assessed systematic age uncertainties stemming from different input physics and mass loss. We discuss the correlation between ages and chemical abundance patterns of field stars over a broad radial range of the Milky Way disc (5 kpc RoGEE observations of a chemodynamical Milky Way disc model indicate that the number of high-metallicity stars in the outer disc is too high to be accounted for even by the strong radial mixing present in the model. The mock observations also show that the age distribution of the [α/Fe]-enhanced sequence in the CoRoGEE inner-disc field is much broader than expected from a combination of radial mixing and observational errors. We suggest that a thick-disc/bulge component that formed stars for more than 3 Gyr may account for these discrepancies. Our results are subject to future improvements due to (a) the still low statistics, because our sample had to be

  18. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo.

    PubMed

    Lewis, E J; Bishop, J; Bottomley, K M; Bradshaw, D; Brewster, M; Broadhurst, M J; Brown, P A; Budd, J M; Elliott, L; Greenham, A K; Johnson, W H; Nixon, J S; Rose, F; Sutton, B; Wilson, K

    1997-06-01

    1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respectively). The compound is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). 2. Ro 32-3555 inhibited interleukin-1 alpha (IL-1 alpha)-induced cartilage collagen degradation in vitro in bovine nasal cartilage explants (IC50 = 60 nM). 3. Ro 32-3555 was well absorbed in rats when administered orally. Systemic exposure was dose related, with an oral bioavailability of 26% at a dose of 25 mg kg-1. 4. Ro 32-3555 prevented granuloma-induced degradation of bovine nasal cartilage cylinders implanted subcutaneously into rats (ED50 = 10 mg kg-1, twice daily, p.o.). 5. Ro 32-3555 dosed once daily for 14 days at 50 mg kg-1, p.o., inhibited degradation of articular cartilage in a rat monoarthritis model induced by an intra-articular injection of Propionibacterium acnes. 6. Ro 32-3555 is a potential therapy for the treatment of the chronic destruction of articulating cartilage in both rheumatoid and osteoarthritis.

  19. Evaluation of the ethanol antagonist' Ro15-4513 on cardiovascular and metabolic responses induced by ethanol

    SciTech Connect

    Lerner, M.R.; Gauvin, D.V.; Holloway, F.A.; Wilson, M.F.; Brackett, D.J. Veterans Affairs Medical Center, Oklahoma City, OK )

    1992-02-26

    The putative ethanol antagonist Ro15-4513 has been reported to attenuate many behavioral responses induced by ethanol, including motor coordination, narcosis, ethanol self administration and intake, and anticonvulsant actions. This study was designed to study the effect of Ro15-4513 on cardiovascular and metabolic responses elicited by intragastric ethanol in conscious rats. Four groups of rats were catheterized under enflurane anesthesia and allowed to regain consciousness. Each group was given either 3.2, 10.0, or 32.0 mg/kg Ro15-4513 or equivalent Tween (i.p.) following ethanol. Ro15-4513 had no effect at any concentration on the decreases in mean arterial pressure, cardiac output, central venous pressure, respiration rate, and cardiac stroke volume and the increases in systemic vascular resistance, heart rate, and glucose evoked by the ethanol challenge. Blood alcohol concentrations measured throughout the study were not affected by any concentration of Ro15-4513. These data suggest that even though Ro15-4513 has significant effects on behavioral responses induced by ethanol it has no effect on the cardiovascular and metabolic responses elicited during ethanol intoxication.

  20. Standard and Short RoM Isokinetic Testing: Comparative Analysis in Identifying Submaximal Shoulder External Rotator Effort.

    PubMed

    Pujol, Eduard; Chaler, Joaquim; Sucarrats, Laura; López, Inés; Zeballos, Blanca; Garreta, Roser; Dvir, Zeevi

    2017-01-31

    An isokinetic-related parameter termed the difference between eccentric-concentric strength ratios at two distinct test velocities (DEC) based on 60° (standard) range of motion (RoM) has been proven to be highly efficient detecting feigned muscular efforts. This study aimed to verify whether a DEC derived from a much shorter test RoM (20°) was equally useful than a long RoM-derived one. Eighteen healthy men (32.4 ± 6.4 years old) took part in a study focusing on shoulder external rotation isokinetic strength. Participants performed a genuine shoulder external rotator maximal effort (eight pairs of concentric and eccentric contractions at high and low velocities at short and long RoM) and then instructed to feign maximal effort. Contraction velocities were adjusted accordingly by applying a 1:4 gradient and peak moments registered. Both condition DEC was then calculated by subtracting the eccentric and concentric strength ratios at low velocities from those at high velocities. DEC scores in the feigned effort were significantly higher than maximal effort ones in both conditions in men. It enabled the setting of specific cutoff levels for separating the efforts. Both approaches revealed a coincident sensitivity (78%) whereas short RoM showed an even higher specificity: 88% versus 78%. Thus, the short RoM protocol provides clinically acceptable detection power.

  1. The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.

    PubMed Central

    Simons, F H; Rutjes, S A; van Venrooij, W J; Pruijn, G J

    1996-01-01

    Ro RNPs are evolutionarily conserved ribonucleoprotein particles that consist of a small RNA, known as Y RNA, associated with several proteins, such as La, Ro60, and Ro52. The Y RNAs (Y1-Y5), which are transcribed by RNA polymerase III, have been shown to reside almost exclusively in the cytoplasm as Ro RNPs. To obtain more insight into the nuclear export pathway of Y RNAs, hY1 RNA export was studied in Xenopus laevis oocytes. Injection of various hY1 RNA mutants showed that an intact Ro60 binding site is a prerequisite for nuclear export, whereas the presence of an intact La binding site resulted in strong nuclear retention of hY1 RNA. Competition studies with various classes of RNAs indicated that, in addition to Ro60, another titratable factor was necessary for nuclear export of hY1 RNA. This factor appears also to be involved in nuclear export of tRNA. Because export of hY1 RNA could not be blocked by a synthetic peptide containing the recently identified nuclear export signal of the HIV-1 Rev protein, nuclear export of hY1 RNA does not seem to be dependent on a Rev-like nuclear export signal. PMID:8608450

  2. Determination of the in vivo redox potential using roGFP and fluorescence spectra obtained from one-wavelength excitation

    NASA Astrophysics Data System (ADS)

    Wierer, S.; Elgass, K.; Bieker, S.; Zentgraf, U.; Meixner, A. J.; Schleifenbaum, F.

    2011-02-01

    The analysis of molecular processes in living (plant) cells such as signal transduction, DNA replication, carbon metabolism and senescence has been revolutionized by the use of green fluorescent protein (GFP) and its variants as specific cellular markers. Many cell biological processes are accompanied by changes in the intracellular redox potential. To monitor the redox potential, a redox-sensitive mutant of GFP (roGFP) was created, which shows changes in its optical properties in response to changes in the redox state of its surrounding medium. For a quantitative analysis in living systems, it is essential to know the optical properties of roGFP in vitro. Therefore, we applied spectrally resolved fluorescence spectroscopy on purified roGFP exposed to different redox potentials to determine shifts in both the absorption and the emission spectra of roGFP. Based on these in vitro findings, we introduce a new approach using one-wavelength excitation to use roGFP for the in vivo analysis of cell biological processes. We demonstrate the ability this technique by investigating chloroplast-located Grx1-roGFP2 expressing Arabidopsis thaliana cells as example for dynamically moving intracellular compartments. This is not possible with the two-wavelength excitation technique established so far, which hampers a quantitative analysis of highly mobile samples due to the time delay between the two measurements and the consequential displacement of the investigated area.

  3. The CoRoT B-type binary HD 50230: a prototypical hybrid pulsator with g-mode period and p-mode frequency spacings⋆

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Michel, E.; Briquet, M.; Pápics, P. I.; Amado, P.; Mathias, P.; Poretti, E.; Rainer, M.; Lombaert, R.; Hillen, M.; Morel, T.; Auvergne, M.; Baglin, A.; Baudin, F.; Catala, C.; Samadi, R.

    2012-06-01

    Context. B-type stars are promising targets for asteroseismic modelling, since their frequency spectrum is relatively simple. Aims: We deduce and summarise observational constraints for the hybrid pulsator, HD 50230, earlier reported to have deviations from a uniform period spacing of its gravity modes. The combination of spectra and a high-quality light curve measured by the CoRoT satellite allow a combined approach to fix the position of HD 50230 in the HR diagram. Methods: To describe the observed pulsations, classical Fourier analysis was combined with short-time Fourier transformations and frequency spacing analysis techniques. Visual spectra were used to constrain the projected rotation rate of the star and the fundamental parameters of the target. In a first approximation, the combined information was used to interpret multiplets and spacings to infer the true surface rotation rate and a rough estimate of the inclination angle. Results: We identify HD 50230 as a spectroscopic binary and characterise the two components. We detect the simultaneous presence of high-order g modes and low-order p and g-modes in the CoRoT light curve, but were unable to link them to line profile variations in the spectroscopic time series. We extract the relevant information from the frequency spectrum, which can be used for seismic modelling, and explore possible interpretations of the pressure mode spectrum. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. Based on observations made with the ESO telescopes at La Silla Observatory under the ESO Large Programme LP182.D-0356, and on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, and on observations obtained with the HERMES

  4. HD 50844: a new look at δ Scuti stars from CoRoT space photometry

    NASA Astrophysics Data System (ADS)

    Poretti, E.; Michel, E.; Garrido, R.; Lefèvre, L.; Mantegazza, L.; Rainer, M.; Rodríguez, E.; Uytterhoeven, K.; Amado, P. J.; Martín-Ruiz, S.; Moya, A.; Niemczura, E.; Suárez, J. C.; Zima, W.; Baglin, A.; Auvergne, M.; Baudin, F.; Catala, C.; Samadi, R.; Alvarez, M.; Mathias, P.; Paparò, M.; Pápics, P.; Plachy, E.

    2009-10-01

    Context: Aims: This work presents the results obtained by CoRoT on HD 50844, the only δ Sct star observed in the CoRoT initial run (57.6 d). The aim of these CoRoT observations was to investigate and characterize for the first time the pulsational behaviour of a δ Sct star, when observed at a level of precision and with a much better duty cycle than from the ground. Methods: The 140 016 datapoints were analysed using independent approaches (SigSpec software and different iterative sine-wave fittings) and several checks performed (splitting of the timeseries in different subsets, investigation of the residual light curves and spectra). A level of 10-5 mag was reached in the amplitude spectra of the CoRoT timeseries. The space monitoring was complemented by ground-based high-resolution spectroscopy, which allowed the mode identification of 30 terms. Results: The frequency analysis of the CoRoT timeseries revealed hundreds of terms in the frequency range 0-30 d-1. All the cross-checks confirmed this new result. The initial guess that δ Sct stars have a very rich frequency content is confirmed. The spectroscopic mode identification gives theoretical support since very high-degree modes (up to ℓ=14) are identified. We also prove that cancellation effects are not sufficient in removing the flux variations associated to these modes at the noise level of the CoRoT measurements. The ground-based observations indicate that HD 50844 is an evolved star that is slightly underabundant in heavy elements, located on the Terminal Age Main Sequence. Probably due to this unfavourable evolutionary status, no clear regular distribution is observed in the frequency set. The predominant term (f_1=6.92 d-1) has been identified as the fundamental radial mode combining ground-based photometric and spectroscopic data. Conclusions: The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria

  5. CoRoT light curves of Blazhko RR Lyrae stars. Evidence of a strong correlation between phase and amplitude modulations of CoRoT ID 0105288363

    NASA Astrophysics Data System (ADS)

    Chadid, M.; Perini, C.; Bono, G.; Auvergne, M.; Baglin, A.; Weiss, W. W.; Deboscher, J.

    2011-03-01

    Context. The CoRoT - Convection Rotation and planetary Transits - space mission provides a unique opportunity to monitor RR Lyrae stars with excellent time-sampling, unprecedented photometric precision, and a long time base of 150 days. Aims: The pulsation characteristics of RR Lyrae stars rely on robust physics, but we still lack a firm quantitative understanding of the physical mechanisms driving the Blazhko modulation and the long-term changes in their pulsation behavior. We use the high-precision space data of an unknown RR Lyrae star CoRoT ID 0105288363 observed during a second long run centered on the Galaxy - LRc02 -, to improve our understanding of the pulsation properties of RR Lyrae stars. Methods: The CoRoT data were corrected using a jump and trend filtering code. We applied different period-finding techniques including Period04, MuFrAn, PDM, and SigSpec. Amplitude and phase modulation were investigated using an analytical function method as well as traditional O-C diagrams. Results: For the first time, we detect significant cycle-to-cycle changes in the Blazhko modulation, which appear to be analogous to those predicted by Stothers - owing to the suppression of turbulent convection - to explain this phenomenon. We discuss the clear correlations between the phase and the amplitude of the bump, and the skewness and acuteness of the light curve during different Blazhko cycles. We find that these quantities are strongly anticorrelated with the fundamental pulsation period. This provides a strong support to the slow convective cycle model suggested by Stothers. We also detect a long-term modulation period in the maximum brightness spectrum. A more extended coverage of the long-term modulation is required to constrain its period. Seventh-order side peaks of the pulsation multiplet structure are also visible with the left-side peak amplitudes being higher than those of the right. This has never previously been detected. Future theoretical investigations are

  6. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. (a) A line drawn from...

  7. Investigating the Relationship between Fin and Blue Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2011-09-30

    Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography...We are investigating the potential correlation between fin whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de...the location of hydrothermal vents 2. Determine whale call counts for ocean bottom seismometers deployed at mid-plate locations on the Explorer and

  8. Continuing Investigations of the Relationship between Fin Whales, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2012-09-30

    Whales, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography...We are investigating the potential correlation between fin whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de...concentrations within the water column above the hydrothermal vents . Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for

  9. Investigating the Relationship Between Fin and Blue Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2009-09-30

    Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography University...are investigating the potential correlation between whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de Fuca...preferentially found above the hydrothermal vent fields where the bio-acoustical data show that the zooplankton concentrations are higher at all depths. 3

  10. Origin of rhyolite by crustal melting and the nature of parental magmas in the Oligocene Conejos Formation, San Juan Mountains, Colorado, USA

    NASA Astrophysics Data System (ADS)

    Parker, D. F.; Ghosh, A.; Price, C. W.; Rinard, B. D.; Cullers, R. L.; Ren, M.

    2005-01-01

    Four closely spaced volcanoes (Summer Coon; Twin Mountains; Del Norte; Carnero Creek) form the east-central cluster of Conejos volcanic centers. These Conejos rocks range from high-K basaltic andesite to rhyolite, with andesite volumetrically the most abundant. Summer Coon and Twin Mountains are composite volcanoes. The Del Norte and Carnero Creek volcanoes are deeply eroded dacite shields. Rhyolite (10% of our Conejos analyses but a much smaller percentage by volume) is only known from Summer Coon and Twin Mountains volcanoes, although high-SiO 2 dacite occurs in the Del Norte volcano. The younger Hinsdale Formation contains a related series ranging from transitional basalt to high-K andesite; we use Hinsdale Formation analyses to represent Conejos parental magmas. Conejos and Hinsdale magmas evolved through AFC processes: Basalt, after interacting with lower crust, assimilated low K/Rb crust, similar in some ways to Taylor and McLennan (Taylor, S.R., and McLennan, S.M., 1985, The continental crust: its composition and evolution. Oxford, Blackwell Scientific.) model upper crust; main series basaltic andesite fractionated to high-K andesite; rhyolite was produced by melting of high K/Ba upper crustal rocks similar to granite gneiss known from inclusions and basement outcrops. Some rhyolite may have been back-mixed into fractionating andesite and dacite. Field evidence for assimilation includes sanidinite-facies, partially melted, gneiss blocks up to 1 m in diameter. Temperature estimates (1100-900 ° C) from two-pyroxene equilibria are consistent with this interpretation, as are the sparsely porphyritic nature of the most-evolved rhyolites and the absence of phenocrystic alkali feldspar. Our study supports the conclusions of previous workers on AFC processes in similar, but generally more mafic, Conejos magmas of the southeastern San Juan Mountains. Our results, however, emphasize the importance of crustal melting in the generation of Conejos rhyolite. We further

  11. Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating.

    PubMed

    Schreiber, Rudy; Vivian, Jef; Hedley, Linda; Szczepanski, Krystine; Secchi, Rob L; Zuzow, Marcus; van Laarhoven, Susanne; Moreau, Jean-Luc; Martin, James R; Sik, Ayhan; Blokland, Arjan

    2007-03-01

    Serotonin(6) (5-HT(6)) receptors are almost exclusively located in the central nervous system. High expression in the hippocampus, nucleus accumbens and striatum is consistent with a potential role in cognition and psychosis. The availability of potent, selective and brain-penetrating 5-HT(6) antagonists such as RO4368554 allows further characterization of the role of the 5-HT(6) receptor in these processes. Herein, we tested RO4368554 in several cognition tasks, as well as sensorimotor gating tests. Using scopolamine-impaired and unimpaired adult male rats, RO4368554 was given in novel object discrimination, social recognition, social discrimination, Morris water maze, passive avoidance and autoshaping procedures. RO4368554 reversed the effects of scopolamine in novel object discrimination (active doses in mg/kg, i.p., 3, 10), social recognition (3, 10), social discrimination (1, 3, 10) and passive avoidance (10, 30 i.p. and 100 p.o.) tasks. In unimpaired rats, RO4368554 enhanced object discrimination (3, 10; 4-h forgetting interval) and autoshaping learning (3), but was inactive in a water maze task (doses tested: 1-10 mg/kg, i.p.). In tests sensitive to antipsychotics, RO4368554 did not reverse sensorimotor gating deficits induced by the psychostimulants dizocilpine and amphetamine (doses tested: 1-30 mg/kg, i.p.) or neonatal lesion of the ventral hippocampus (1-10 mg/kg, i.p.). In conclusion, RO4368554 enhanced learning and memory processes in unimpaired and scopolamine-impaired rats, supporting the notion that the cognitive enhancing effects of 5-HT(6) receptor antagonists involve modulation of cholinergic neurotransmission.

  12. Characterization and biotoxicity assessment of dissolved organic matter in RO concentrate from a municipal wastewater reclamation reverse osmosis system.

    PubMed

    Sun, Ying-Xue; Gao, Yue; Hu, Hong-Ying; Tang, Fang; Yang, Zhe

    2014-12-01

    Reverse osmosis (RO) concentrate from municipal wastewater reclamation reverse osmosis (mWRRO) system containing organic compounds may associate with toxic risk, and its discharge might pose an environmental risk. To identify a basis for the selection of feasible technology in treating RO concentrates, the characteristics and biotoxicity of different fractions of dissolved organic matter (DOM) in RO concentrates from an mWRRO system were investigated. The results indicated that the hydrophilic neutrals (HIN), hydrophobic acids (HOA) and hydrophobic bases (HOB) accounted for 96% of the dissolved organic carbon (DOC) of the total DOM in the RO concentrate. According to the SEC chromatograph detected at 254 nm wavelength of UV, the DOM with molecular weight (MW) 1-3 kDa accounted for the majority of the basic and neutral fractions. The fluorescence spectra of the excitation emission matrix (EEM) indicated that most aromatic proteins, humic/fulvic acid-like and soluble microbial by-product-like substances existed in the fractions HOA and hydrophobic neutrals (HON). The genotoxicity and anti-estrogenic activity of the RO concentrate were 1795.6 ± 57.2 μg 4-NQOL(-1) and 2.19 ± 0.05 mg TAM L(-1), respectively. The HIN, HOA, and HOB contributed to the genotoxicity of the RO concentrate, and the HIN was with the highest genotoxic level of 1007.9 ± 94.8 μg 4-NQOL(-1). The HOA, HON, and HIN lead to the total anti-estrogenic activity of the RO concentrate, and HOA occupied approximately 60% of the total, which was 1.3 ± 0.17 mg TAM L(-1).

  13. Surface display of roGFP for monitoring redox status of extracellular microenvironments in Shewanella oneidensis biofilms.

    PubMed

    Sivakumar, Krishnakumar; Mukherjee, Manisha; Cheng, Hsin-I; Zhang, Yingdan; Ji, Lianghui; Cao, Bin

    2015-03-01

    Biofilms are the most ubiquitous and resilient form of microbial life on earth. One most important feature of a biofilm is the presence of a self-produced matrix, which creates highly heterogeneous and dynamic microenvironments within biofilms. Redox status in biofilm microenvironments plays a critical role in biofilm development and function. However, there is a lack of non-intrusive tools to quantify extracellular redox status of microenvironments within a biofilm matrix. In this study, using Shewanella oneidensis as a model organism, we demonstrated a novel approach to monitor extracellular redox status in biofilm microenvironments. Specifically, we displayed a redox sensitive fluorescence protein roGFP onto the cell surface of S. oneidensis by fusing it to the C-terminus of BpfA, a large surface protein, and used the surface displayed roGFP as a sensor to quantify the extracellular redox status in the matrix of S. oneidensis biofilms. The fusion of roGFP into BpfA has no negative impacts on cell growth and biofilm formation. Upon exposure to oxidizing agents such as H2 O2 , Ag(+) , and SeO3 (2-) , S. oneidensis BpfA-roGFP cells exhibited a characteristic fluorescence of roGFP. Proteinase treatment assay and super-resolution structured illumination microscopy confirmed the surface localization of BpfA-roGFP. We further used the surface displayed roGFP monitored the extracellular redox status in the matrix at different depths of a biofilm exposed to H2 O2 . This study provides a novel approach to non-invasively monitor extracellular redox status in microenvironments within biofilms, which can be used to understand redox responses of biofilms to environmental perturbations.

  14. Five Years of the RoBOT "Rocks Beneath Our Toes" High School Outreach Program

    NASA Astrophysics Data System (ADS)

    Baxter, E. F.

    2011-12-01

    The "Rocks Beneath Our Toes" or RoBOT Program began in 2006 as part of an NSF CAREER award through the Geochemistry and Petrology Program. The educational outreach program engages Boston area high school students in a hands on study of rocks and minerals collected in their communities. The goal is to provide high school students a unique window into modern scientific methods of geochemistry and mineralogy and create a higher level of interest and awareness of geoscience amongst Massachusetts secondary school students who are less often exposed to earth science coursework. Beginning with a joint field trip to sampling sites identified by participants, high school students work with Boston University undergraduates enrolled in Mineralogy to analyze their samples in thin section. During the field trip, each BU undergraduate is paired with a high school student. The assignment of student pairings (started in year 2) dramatically increased student interactions and enjoyment. The program culminates with a visit by the high school group to tour BU's lab facilities and work with the undergraduates using the petrographic microscopes to explore their rock. At this visit, BU undergraduates present their semester's work in one-on-one powerpoint presentations from which discussion and microscope work follow. Thus far, >50 high school students, >40 undergraduates, and 7 high school educators were involved in the program. This included participants from three different suburban Boston area high schools and with students enrolled in the BU "Upward Bound" program: an existing program designed to enhance educational opportunities for Boston inner city high school students. Participant reviews indicate great success in achieving the program's goals. Notably, both BU undergraduates and high school students rated the opportunities for interaction with eachother among the best aspects of RoBOT. On a scale of 1 to 10, BU undergraduates rated the following four categories highest

  15. New RoF-PON architecture using polarization multiplexed wireless MIMO signals for NG-PON

    NASA Astrophysics Data System (ADS)

    Elmagzoub, M. A.; Mohammad, Abu Bakar; Shaddad, Redhwan Q.; Al-Gailani, Samir A.

    2015-06-01

    Next-generation access networks require provision of wireless services and high data rate to meet the huge demands for mobility and multiple services. Moreover, reusing the currently deployed optical distribution networks (ODNs) is highly beneficial and cost effective for providing the new high data rate wireless demands. In this paper, bidirectional radio over fiber passive optical network (RoF-PON) capable of handling multiple-input-multiple-output (MIMO) streams at low cost, high spectral efficiency and backward compatibility with currently deployed PON, is proposed. To the best of our knowledge, all the existing RoF MIMO solutions have not considered compatibility with currently deployed ODNs. Eight laser diodes (LDs) at the central office (CO) are enough for the whole system, instead of having LD or optical transmitter at each remote antenna unit (RAU), which makes a colorless and cost-effective RAU. Twenty four wavelengths are generated using optical comb technique. Each two 16-QAM MIMO signals that have the same carrier frequency in the downstream (DS) transmission are optically combined using polarization-division-multiplexing (PDM), where each two upstream (US) MIMO signals are time division multiplexed. The PDM configuration doubles spectral efficiency with a power penalty of only 1.5 dB. The proposed architecture is a bidirectional asymmetric RoF-PON with total 40/10 Gb/s for DS/US transmission. Even after transmission over 20 km SMF and splitting ratio of 32, acceptable transmission performance and widely separated constellation diagrams for the 16-QAM signals are achieved, with bit error rate (BER) of 10-6 for DS signals and 10-3 for the US signals which can be reduced down to 10-6 by using forward error correction (FEC).

  16. Potential Return on Investment (RoI) on web-based diabetes education in UK.

    PubMed

    Shabestari, Omid; Roudsari, Abdul

    2009-01-01

    The incidence of diabetes mellitus is growing in the UK. As most diabetes care is performed by the patients themselves, structured education is one way to encourage their responsible participation in delivering effective care. Continuous e-learning by Internet has proven to be a useful method of diabetes education. "Return on Investment" (RoI) can be used as an indicator of the cost-benefit of web-based education. RoI is the ratio of money gained or lost on an investment relative to the amount of money invested. This report uses system dynamics modeling to predict the flow of patients in the educational system and the cost of their care. The analysis compared traditional and web-based education. Separate models were developed for each educational method and simulated until 2020 in one year intervals. The population of diabetic patients was adjusted at each cycle according to anticipated incidence and mortality rates. The population of educated diabetic patients was based on the educational capacity and literacy limits of each method. A report by the National Health Service (NHS) was used to calculate the cost of care by considering the cost difference between uneducated and educated patients. By 2020 with an annual rate of inflation of 3%, the annual cost of care is projected to increase to pound 3.67 billion for the traditional model as compared to pound 3.39 billion for the web-based model. RoI is estimated to be a ratio of 32.33. Investment in web-based diabetes education is not only a health benefit but also a reduction in care cost.

  17. Rotation period distribution of CoRoT and Kepler Sun-like stars

    NASA Astrophysics Data System (ADS)

    Leão, I. C.; Pasquini, L.; Ferreira Lopes, C. E.; Neves, V.; Valcarce, A. A. R.; de Oliveira, L. L. A.; Freire da Silva, D.; de Freitas, D. B.; Canto Martins, B. L.; Janot-Pacheco, E.; Baglin, A.; De Medeiros, J. R.

    2015-10-01

    Aims: We study the distribution of the photometric rotation period (Prot), which is a direct measurement of the surface rotation at active latitudes, for three subsamples of Sun-like stars: one from CoRoT data and two from Kepler data. For this purpose, we identify the main populations of these samples and interpret their main biases specifically for a comparison with the solar Prot. Methods: Prot and variability amplitude (A) measurements were obtained from public CoRoT and Kepler catalogs, which were combined with public data of physical parameters. Because these samples are subject to selection effects, we computed synthetic samples with simulated biases to compare with observations, particularly around the location of the Sun in the Hertzsprung-Russel (HR) diagram. Publicly available theoretical grids and empirical relations were used to combine physical parameters with Prot and A. Biases were simulated by performing cutoffs on the physical and rotational parameters in the same way as in each observed sample. A crucial cutoff is related with the detectability of the rotational modulation, which strongly depends on A. Results: The synthetic samples explain the observed Prot distributions of Sun-like stars as having two main populations: one of young objects (group I, with ages younger than ~1 Gyr) and another of main-sequence and evolved stars (group II, with ages older than ~1 Gyr). The proportions of groups I and II in relation to the total number of stars range within 64-84% and 16-36%, respectively. Hence, young objects abound in the distributions, producing the effect of observing a high number of short periods around the location of the Sun in the HR diagram. Differences in the Prot distributions between the CoRoT and Kepler Sun-like samples may be associated with different Galactic populations. Overall, the synthetic distribution around the solar period agrees with observations, which suggests that the solar rotation is normal with respect to Sun

  18. Reassessing the radial-velocity evidence for planets around CoRoT-7

    NASA Astrophysics Data System (ADS)

    Pont, Frédéric; Aigrain, Suzanne; Zucker, Shay

    2011-03-01

    CoRoT-7 is an 11 th magnitude K-star whose light curve shows transits with a depth of 0.3 mmag and a period of 0.854 d, superimposed on variability at the 1 per cent level, due to the modulation of evolving active regions with the star's 23-d rotation period. In this paper, we revisit the published HARPS radial-velocity (RV) measurements of the object, which were previously used to estimate the companion mass, but have been the subject of ongoing debate. We build a realistic model of the star's activity during the HARPS observations, by fitting simultaneously the linewidth (as measured by the width of the cross-correlation function) and the line bisector, and use it to evaluate the contribution of activity to the RV variations. The data show clear evidence of errors above the level of the formal uncertainties, which are accounted for neither by activity nor by any plausible planet model and which increase rapidly with a decreasing signal-to-noise ratio (S/N) of the spectra. We cite evidence of similar systematics in mid-S/N spectra of other targets obtained with HARPS and other high-precision RV spectrographs, and discuss possible sources. Allowing for these, we re-evaluate the semi-amplitude of the CoRoT-7b signal, finding Kb= 1.6 ± 1.3 m s-1, a tentative detection with a much reduced significance (1.2σ) compared to previous estimates. We also argue that the combined presence of activity and additional errors precludes a meaningful search for additional low-mass companions, despite previous claims to the contrary. Taken at face value, our analysis points to a lower density for CoRoT-7b, the 1σ mass range spanning 1-4 M ⊕ and allowing for a wide range of bulk compositions. In particular, an ice-rich composition is compatible with the RV constraints. More generally, this study highlights the importance of a realistic treatment of both activity and uncertainties, particularly in the medium S/N regime, which applies to most small planet candidates from CoRoT and

  19. roAp stars: surface lithium abundance distribution and magnetic field configuration

    NASA Astrophysics Data System (ADS)

    Polosukhina, N.; Shulyak, D.; Shavrina, A.; Lyashko, D.; Drake, N. A.; Glagolevski, Yu.; Kudryavtsev, D.; Smirnova, M.

    2014-08-01

    High-resolution spectra obtained with the 6m BTA telescope, Russia, and with HARPS and VLT/UVES telescopes at ESO, Chile, were used for Doppler Imaging analysis of two roAp stars, HD 12098 and HD 60435, showing strong and variable Li resonance line in their spectra. We found that Li has highly inhomogeneous distribution on the surfaces of these stars. We compared our results with previously obtained Doppler Imaging mapping of two CP2 stars, HD 83368 and HD 3980, and discuss the correlation between the position of the high Li-abundance spots and magnetic field.

  20. SPM4: The Yale/San-Juan Southern Proper Motion survey: 100 million absolute proper motions

    NASA Astrophysics Data System (ADS)

    van Altena, W. F.; Girard, T. M.; Casetti, D. I.; Vieira, K.; López, C. E.; Castillo, D.; Monet, D.; Zacharias, N.; Korchagin, V. I.; Platais, I.; Lee, Y. S.; Beers, T. C.; Herrera, D.

    The Yale/San Juan Southern Proper Motion SPM4 Catalog is the culmi- nation of a highly successful 47-year collaboration between the National University of San Juan (UNSJ) and the Yale Southern Observatory (YSO). The SPM4 Catalog contains absolute proper motions, celestial coordinates, blue and visual passband photometry for 103,319,647 stars and galaxies be- tween the south celestial pole and -20 degrees declination. The Catalog is roughly complete to V=17.5 and the precision of its positions and absolute proper motions is approximately 30 to 150 mas and 2 to 10 mas/yr, respec- tively. It is based on photographic and CCD observations taken with the Yale Southern Observatory's double-astrograph at the Cesco Observatory in El Leoncito, Argentina.

  1. ["Is it an animal inside? "Melanie Klein's unpublished Don Juan Paper (1939)].

    PubMed

    Frank, Claudia

    2008-01-01

    Klein had been asked to contribute an article to the birthday number of the International Journal for Jones. The author outlines how she hurriedly wrote a text about Don Juan which, however, was rejected by the editor. Essential parts of it are presented in German translation. The manuscript is discussed in the context of Klein's published work as well as of the relevant contemporary literature. In Klein's view, Don Juan's genitality is determined by oral impulses and fears. By his manic acting out he attempts to ward off a depressive break-down. The paper ends with some reflections about why Klein--ontrary to her intention--failed to revise her manuscript for later publication.

  2. Abiotic nitrous oxide emission from the hypersaline Don Juan Pond in Antarctica

    NASA Astrophysics Data System (ADS)

    Samarkin, Vladimir A.; Madigan, Michael T.; Bowles, Marshall W.; Casciotti, Karen L.; Priscu, John C.; McKay, Christopher P.; Joye, Samantha B.

    2010-05-01

    Nitrous oxide is a potent atmospheric greenhouse gas that contributes to ozone destruction. Biological processes such as nitrification and denitrification are thought to drive nitrous oxide production in soils, which comprise the largest source of nitrous oxide to the atmosphere. Here we present measurements of the concentration and isotopic composition of nitrous oxide in soil pore spaces in samples taken near Don Juan Pond, a metabolically dormant hypersaline pond in Southern Victoria Land, Antarctica in 2006, 2007 and 2008, together with in situ fluxes of nitrous oxide from the soil to the atmosphere. We find fluxes of nitrous oxide that rival those measured in fertilized tropical soils. Laboratory experiments-in which nitrite-rich brine was reacted with a variety of minerals containing Fe(II)-reveal a new mechanism of abiotic water-rock reaction that could support nitrous oxide fluxes at Don Juan Pond. Our findings illustrate a dynamic and unexpected link between the geosphere and atmosphere.

  3. Further paleomagnetic results for the San Juan volcanic field of southern Colorado

    USGS Publications Warehouse

    Beck, M.E.; Sheriff, S.D.; Diehl, J.F.; Hailwood, E.A.; Lipman, P.W.

    1977-01-01

    Combining paleomagnetic data for 17 new sites from the northwest portion of the (Oligocene) San Juan volcanic field of southern Colorado with data for 29 sites previously published yields a paleomagnetic pole at 85??N, 114??E (with a 95% confidence circle of 7.5?? radius). A further combination of the San Juan data with the results of other studies on rocks of Oligocene age from tectonically stable parts of North America gives a mid-Tertiary reference pole located at 81??N, 132.5??E, with a confidence circle of approximately 4??. Mid-Tertiary paleomagnetic poles for the western edge of the continent diverge markedly from this reference pole. ?? 1977.

  4. Impacts of Urbanization in the Coastal Tropical City of San Juan, Puerto Rico

    NASA Technical Reports Server (NTRS)

    Comarazamy, Daniel E.; Gonzalez, Jorge E.; Luvall, Jeffrey C.; Rickman, Douglass

    2007-01-01

    Urban sprawl in tropical locations is rapidly accelerating and it is more evident in islands where a large percentage of the population resides along the coasts. This paper focuses on the analysis of the impacts of land use and land cover for urbanization in the tropical coastal city of San Juan, in the Caribbean island of Puerto Rico. A mesoscale numerical model, the Regional Atmospheric Modeling System (RAMS), is used to study the impacts of land use for urbanization in the environment including specific characteristics of the urban heat island in the San Juan Metropolitan Area (SJMA), one of the most noticeable urban cores of the Caribbean. The research also makes use of the observations obtained during the airborne San Juan Atlas Mission. Surface and raw insonde data from the mission are used to validate the atmospheric model yielding satisfactory results. Airborne high resolution remote sensing data are used to update the model's surface characteristics in order to obtain a more accurate and detailed configuration of the SJMA and perform a climate impact analysis based on land cover/land use (LCLU) changes. The impact analysis showed that the presence of the urban landscape of San Juan has an impact reflected in higher air temperatures over the area occupied by the city, with positive values of up to 2.5 degrees C, for the simulations that have specified urban LCLU indexes in the model's bottom boundary. One interesting result of the impact analysis was the finding of a precipitation disturbance shown as a difference in total accumulated rainfall between the present urban landscape and with a potential natural vegetation, apparently induced by the presence of the urban area. Results indicate that the urban-enhanced cloud formation and precipitation development occur mainly downwind of the city, including the accumulated precipitation. This spatial pattern can be explained by the presence of a larger urbanized area in the southwest sector of the city, and of

  5. Reflections on Don Juan and on the utility of the unhappy love affair.

    PubMed

    Bergel, Ernest

    2011-12-01

    Based on an unusual clinical experience of a teenage boy in child psychotherapy, two conclusions are proposed: (1) that the extremely unhappy, early love affairs that occur in most men's lives serve a valuable function in helping them separate from their mothers sufficiently to be able to realistically relate to appropriate marriage partners, and (2) that some Don Juans start new relationships in order to break them off, rather than the reverse.

  6. Transform push, oblique subduction resistance, and intraplate stress of the Juan de Fuca plate

    USGS Publications Warehouse

    Wang, K.; He, J.; Davis, E.E.

    1997-01-01

    The Juan de Fuca plate is a small oceanic plate between the Pacific and North America plates. In the southernmost region, referred to as the Gorda deformation zone, the maximum compressive stress a, constrained by earthquake focal mechanisms is N-S. Off Oregon, and possibly off Washington, NW trending left-lateral faults cutting the Juan de Fuca plate indicate a a, in a NE-SW to E-W direction. The magnitude of differential stress increases from north to south; this is inferred from the plastic yielding and distribution of earthquakes throughout the Gorda deformation zone. To understand how tectonic forces determine the stress field of the Juan de Fuca plate, we have modeled the intraplate stress using both elastic and elastic-perfectly plastic plane-stress finite element models. We conclude that the right-lateral shear motion of the Pacific and North America plates is primarily responsible for the stress pattern of the Juan de Fuca plate. The most important roles are played by a compressional force normal to the Mendocino transform fault, a result of the northward push by the Pacific plate and a horizontal resistance operating against the northward, or margin-parallel, component of oblique subduction. Margin-parallel subduction resistance results in large N-S compression in the Gorda deformation zone because the force is integrated over the full length of the Cascadia subduction zone. The Mendocino transform fault serves as a strong buttress that is very weak in shear but capable of transmitting large strike-normal compressive stresses. Internal failure of the Gorda deformation zone potentially places limits on the magnitude of the fault-normal stresses being transmitted and correspondingly on the magnitude of strike-parallel subduction resistance. Transform faults and oblique subduction zones in other parts of the world can be expected to transmit and create stresses in the same manner. Copyright 1997 by the American Geophysical Union.

  7. The paradigm of paraglacial megafans of the San Juan river basin, Central Andes, Argentina

    NASA Astrophysics Data System (ADS)

    Suvires, Graciela M.

    2014-11-01

    The spatial distribution and several morphometric characteristics of the Quaternary alluvial fans of the San Juan River, in the province of San Juan, at the Central and Western part of Argentina, have been studied to classify them as paraglacial megafans, as well to ratify its depositional environmental conditions. The high sedimentary load exported by San Juan river from the Central Andes to the foreland depressions is estimated about 3,682,200 hm3. The large alluvial fans of Ullum-Zonda and Tulum valleys were deposited into deep tectonic depressions, during the Upper Pleistocene deglaciation stages. The outcome of collecting remotely sensed data, map and DEM data, geophysical data and much fieldwork gave access to morphometric, morphographic and morphogenetic data of these alluvial fans. The main drainage network was mapped on processed images using QGis (vers.2.0.1). Several fan morphometric parameters were measured, such as the size, the shape, the thickness, the surface areas and the sedimentary volume of exported load. The analyzed fans were accumulated in deep tectonic depressions, where the alluvium fill reaches 700 to 1200 m thick. Such fans do not reach the large size that other world megafans have, and this is due to tectonic obstacles, although the sedimentary fill average volume surpasses 514,000 hm3. The author proposes to consider Ullum-Zonda and Tulum alluvial fans as paraglacial megafans. According to the stratigraphic relationships of the tropical South American Rivers, the author considers that the San Juan paraglacial megafans would have occurred in the period before 24 ka BP , possibly corresponding to Middle Pleniglacial (ca 65-24ka BP). They record colder and more humid conditions compared with the present arid and dry conditions.

  8. Juan Ruiz De Alarcón: Impairment as Empowerment in Early Modern Spain

    ERIC Educational Resources Information Center

    Clark, Gloria Bodtorf

    2016-01-01

    Juan Ruiz de Alarcón, a seventeenth-century writer and native of New Spain, so excelled at the craft of writing "comedias" that he is recognized as one of the great writers of early modern Spain. In his personal life Ruiz de Alarcón struggled with a significant bodily impairment, a large hump on both his back and front, which made him…

  9. Temporal Geochemistry Data from Five Springs in the Cement Creek Watershed, San Juan County, Colorado

    USGS Publications Warehouse

    Johnson, Raymond H.; Wirt, Laurie; Leib, Kenneth J.

    2008-01-01

    Temporal data from five springs in the Cement Creek watershed, San Juan County, Colorado provide seasonal geochemical data for further research in the formation of ferricretes. In addition, these data can be used to help understand the ground-water flow system. The resulting data demonstrate the difficulty in gathering reliable seasonal data from springs, show the unique geochemistry of each spring due to local geology, and provide seasonal trends in geochemistry for Tiger Iron Spring.

  10. Geologic map of the Cochetopa Park and North Pass Calderas, northeastern San Juan Mountains, Colorado

    USGS Publications Warehouse

    Lipman, Peter W.

    2012-01-01

    The San Juan Mountains in southwestern Colorado have long been known as a site of exceptionally voluminous mid-Tertiary volcanism, including at least 22 major ignimbrite sheets (each 150-5,000 km3) and associated caldera structures active at 33-23 Ma. Recent volcanologic and petrologic studies in the San Juan region have focused mainly on several ignimbrite-caldera systems: the southeastern area (Platoro complex), western calderas (Uncompahgre-Silverton-Lake City), and the central cluster (La Garita-Creede calderas). Far less studied has been the northeastern San Juan region, which occupies a transition between earlier volcanism in central Colorado and large-volume younger ignimbrite-caldera foci farther south and west. The present map is based on new field coverage of volcanic rocks in seventeen 7.5' quadrangles in northeastern parts of the volcanic field, high-resolution age determinations for 120 new sites, and petrologic studies involving several hundred new chemical analyses. This mapping and the accompanying lab results (1) document volcanic evolution of the previously unrecognized North Pass caldera and the morphologically beautifully preserved but enigmatic Cochetopa basin, including unique features not previously described from ignimbrite calderas elsewhere; (2) provide evidence for a more rapid recurrence of large ignimbrite eruptions than previously known elsewhere; (3) quantify the regional time-space-volume progression from the earlier Sawatch magmatic trend southward into the San Juan region; and (4) permit more rigorous comparison between the broad mid-Tertiary magmatic belt in the western U.S. Cordillera and the type continental-margin arc volcanism in the central Andes.

  11. No spreading across the southern Juan de Fuca ridge axial cleft during 1994-1996

    USGS Publications Warehouse

    Chadwell, C.D.; Hildebrand, J.A.; Spiess, Fred N.; Morton, J.L.; Normark, W.R.; Reiss, C.A.

    1999-01-01

    Direct-path acoustic measurements between seafloor transponders observed no significant extension (-10 ?? 14 mm/yr) from August 1994 to September 1996 at the southern Juan de Fuca Ridge (44??40' N and 130??20' W). The acoustic path for the measurement is a 691-m baseline straddling the axial cleft, which bounds the Pacific and Juan de Fuca plates. Given an expected full-spreading rate of 56 mm/yr, these data suggest that extension across this plate boundary occurs episodically within the narrow (~1 km) region of the axial valley floor, and that active deformation is occurring between the axial cleft and the plate interior. A cleft-parallel 714-m baseline located 300 m to the west of the cleft on the Pacific plate monitored system performance and, as expected, observed no motion (+5??7 mm/yr) between the 1994 and 1996 surveys.Direct-path acoustic measurements between seafloor transponders observed no significant extension (-10 ?? 14 mm/yr) from August 1994 to September 1996 at the southern Juan de Fuca Ridge (44??40 minutes N and 130??20 minutes W). The acoustic path for the measurement is a 691-m baseline straddling the axial cleft, which bounds the Pacific and Juan de Fuca plates. Given an expected full-spreading rate of 56 mm/yr, these data suggest that extension across this plate boundary occurs episodically within the narrow (approx. 1 km) region of the axial valley floor, and that active deformation is occurring between the axial cleft and the plate interior. A cleft-parallel 714-m baseline located 300 m to the west of the cleft on the Pacific plate monitored system performance and, as expected, observed no motion (+5 ?? 7 mm/yr) between the 1994 and 1996 surveys.

  12. Juan César García: social medicine as project and endeavor.

    PubMed

    Nunes, Everardo Duarte

    2015-01-01

    This paper analyses some aspects of the trajectory of the Argentinian physician and sociologist Juan César García (1932-1984) in the field of Latin American Social Medicine. Three dimensions constituting his basic orientations are highlighted: the elaboration of systematic and reflective social thought; a critical attitude in questioning teaching and professional practices; a commitment to the institutionalization and dissemination of health knowledge.

  13. Li and Ag Co-Doped ZnO Photocatalyst for Degradation of RO 4 Dye Under Solar Light Irradiation.

    PubMed

    Dhatshanamurthi, P; Shanthi, M

    2016-06-01

    The synthesis of Li doped Ag-ZnO (Li-Ag-ZnO) has been successfully achieved by a sonochemically assisted precipitation-decomposition method. The synthesized catalyst was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDS), diffuse reflectance spectra (DRS), photoluminescence spectra (PL), X-ray photoelectron spectra (XPS) and BET surface area measurements. The photocatalytic activity of Li-Ag-ZnO was investigated for the degradation of Reactive orange 4 (RO 4) dye in aqueous solution under solar light irradiation. Co-dopants shift the absorbance of ZnO to the visible region. Li-Ag-ZnO is found to be more efficient than Ag-ZnO, Li-ZnO, commercial ZnO and prepared ZnO at pH 7 for the mineralization of RO 4 dye under solar light irradiation. The influences of operational parameters such as the amount of photocatalyst, dye concentration, initial pH on photo-mineralization of RO 4 have been analyzed. The mineralization of RO 4 dye has been confirmed by COD measurements. A degradation mechanism is proposed for the degradation of RO 4 under solar light. The catalyst was found to be more stable and reusable.

  14. Refractory depression: mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: protocol for randomised trial

    PubMed Central

    Lynch, T R; Whalley, B; Hempel, R J; Byford, S; Clarke, P; Clarke, S; Kingdon, D; O'Mahen, H; Russell, I T; Shearer, J; Stanton, M; Swales, M; Watkins, A; Remington, B

    2015-01-01

    Introduction Only 30–40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression. Methods and analysis REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective. Ethics and dissemination The National Research Ethics Service (NRES) Committee South Central – Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146. Trial registration number ISRCTN85784627. PMID:26187121

  15. The study of CD20 and CD45.Ro antibodies in the inflammatory infiltrate involved in acne and seborrheic dermatitis.

    PubMed

    Ianoşi, Simona; Stoicescu, Irina; Ianoşi, G; Neagoe, Daniela; Georgescu, Claudia Valentina

    2007-01-01

    The aim of our study was to evaluate the role of CD20 and CD45.Ro antibodies in acne and seborrheic dermatitis. A number of 20 patients with papular, pustular or nodular acne and another 20 patients with seborrheic dermatitis were available for our study. We removed bioptic material from all of them and we perform histochemical and immunohistochemical processing within the Laboratory of Histology, Histopathology and Immunohistochemistry of the University of Medicine and Pharmacy of Craiova. In acne, we could reveal a positive CD45.Ro immunomarking in rare lymphoid cells situated in the middle derma at a distance from the affected pilosebaceous follicle and in the inflammatory infiltrate subepidermically, and also a negative immunomarking in the inflammatory cells from the proximity of the affected pilosebaceous follicle. In patients with seborrheic dermatitis we noticed a positive immunomarking infiltrate of the papillary derma and a positive immunomarking of membrane for CD45.Ro in many lymphoid cells of the inflammatory infiltrate situated in the papillary derma predominantly disposed perivasculary. Conclusions. The absence of the cells marked with CD45.Ro in the proximity of the pilosebaceous follicle interested in acne excludes the direct participation of B- and T-lymphocytes in the perifollicular inflammatory process, though the T-lymphocytes can be revealed in a small number at a distance from the affected follicle. The inflammatory infiltrate from the seborrheic dermatitis proved to be rich in positive CD45.Ro cells and poorer in positive CD20 cells.

  16. A new approach for determination of fouling potential by colloidal nanoparticles during reverse osmosis (RO) membrane filtration of seawater

    NASA Astrophysics Data System (ADS)

    Park, Ji Yeon; Lim, Sungil; Park, Kihong

    2013-04-01

    A direct measurement of number concentration of colloidal nanoparticles (15-450 nm) in water was made with the membrane filtration-differential mobility analyzer technique, and its corresponding flux decline rate (FDR) was determined by laboratory-scale RO fouling test unit using varying number concentrations of silica nanoparticles in artificial seawaters. This relationship was used to predict fouling potential of colloidal nanoparticles in reverse osmosis (RO) membrane process of seawaters in RO plant. It was found that the FDR linearly increased with the increasing number of colloidal nanoparticles for the given concentration range and that the relationship between the number concentration and the FDR also depended on RO membrane surface properties. Data for estimated FDR values for natural seawaters after pretreatment showed a clear difference among samples, which is contrary to the pre-existing index such as silt density index and modified fouling index. Our data suggest that measurement of colloidal nanoparticles is useful for selection of proper pretreatment and successful operation of RO membrane process along with other particle fouling predictors accounting for large particles (>450 nm).

  17. BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data

    PubMed Central

    Narasimhan, Vagheesh; Danecek, Petr; Scally, Aylwyn; Xue, Yali; Tyler-Smith, Chris; Durbin, Richard

    2016-01-01

    Summary: Runs of homozygosity (RoHs) are genomic stretches of a diploid genome that show identical alleles on both chromosomes. Longer RoHs are unlikely to have arisen by chance but are likely to denote autozygosity, whereby both copies of the genome descend from the same recent ancestor. Early tools to detect RoH used genotype array data, but substantially more information is available from sequencing data. Here, we present and evaluate BCFtools/RoH, an extension to the BCFtools software package, that detects regions of autozygosity in sequencing data, in particular exome data, using a hidden Markov model. By applying it to simulated data and real data from the 1000 Genomes Project we estimate its accuracy and show that it has higher sensitivity and specificity than existing methods under a range of sequencing error rates and levels of autozygosity. Availability and implementation: BCFtools/RoH and its associated binary/source files are freely available from https://github.com/samtools/BCFtools. Contact: vn2@sanger.ac.uk or pd3@sanger.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online. PMID:26826718

  18. Carbon Isotopic tests on the Origins of the Shuram Anomaly from the San Juan Fm., Peru

    NASA Astrophysics Data System (ADS)

    Hodgin, E. B.

    2015-12-01

    Carbon isotope anomalies are associated with perturbations to the carbon cycle that offer insight into the geochemical evolution of the Earth. The largest Carbon isotope anomaly in earth history is the Shuram, which remains poorly understood in spite of being linked to the oxygenation of earth, the rise of metazoans, and a complete reorganization of the carbon cycle. From a basin transect of the carbonate-dominated San Juan Formation in southern Peru, we present evidence for the first clear example of the Shuram isotope anomaly in South America. Unique to this succession are ~140 meters of organic-rich black shale within the anomaly, containing as much as 4% TOC. Preliminary data from the organic-rich black shales of the San Juan Fm. confirm that δ13Corg is relatively invariant and does not covary with δ13Ccarb. These observations are consistent with other Shuram sections and support various models: an exogenous carbon source, an enlarged dissolved organic carbon pool, as well as authigenic carbonate production in organic-rich anoxic sediments. Critical tests of these models have been complicated by a paucity of organics in Shuram facies worldwide. Further analyses of the robust organics from the Shuram facies of the San Juan Fm. therefore hold promise in shedding light on the origin of the Shuram isotope anomaly and critical earth history events to which it has been linked.

  19. Assessing Climate Variability Effects on Dengue Incidence in San Juan, Puerto Rico

    PubMed Central

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E.; Otis, Daniel; McCarthy, Matthew J.; Peña-Orellana, Marisol

    2014-01-01

    We test the hypothesis that climate and environmental conditions are becoming favorable for dengue transmission in San Juan, Puerto Rico. Sea Level Pressure (SLP), Mean Sea Level (MSL), Wind, Sea Surface Temperature (SST), Air Surface Temperature (AST), Rainfall, and confirmed dengue cases were analyzed. We evaluated the dengue incidence and environmental data with Principal Component Analysis, Pearson correlation coefficient, Mann-Kendall trend test and logistic regressions. Results indicated that dry days are increasing and wet days are decreasing. MSL is increasing, posing higher risk of dengue as the perimeter of the San Juan Bay estuary expands and shorelines move inland. Warming is evident with both SST and AST. Maximum and minimum air surface temperature extremes have increased. Between 1992 and 2011, dengue transmission increased by a factor of 3.4 (95% CI: 1.9–6.1) for each 1 °C increase in SST. For the period 2007–2011 alone, dengue incidence reached a factor of 5.2 (95% CI: 1.9–13.9) for each 1 °C increase in SST. Teenagers are consistently the age group that suffers the most infections in San Juan. Results help understand possible impacts of different climate change scenarios in planning for social adaptation and public health interventions. PMID:25216253

  20. Geologic map of the central San Juan caldera cluster, southwestern Colorado

    USGS Publications Warehouse

    Lipman, Peter W.

    2006-01-01

    The San Juan Mountains are the largest erosional remnant of a composite volcanic field that covered much of the southern Rocky Mountains in middle Tertiary time. The San Juan field consists mainly of intermediate-composition lavas and breccias, erupted about 35-30 Ma from scattered central volcanoes (Conejos Formation) and overlain by voluminous ash-flow sheets erupted from caldera sources. In the central San Juan Mountains, eruption of at least 8,800 km3 of dacitic-rhyolitic magma as nine major ash flow sheets (individually 150-5,000 km3) was accompanied by recurrent caldera subsidence between 28.3 Ma and about 26.5 Ma. Voluminous andesitic-dacitic lavas and breccias erupted from central volcanoes prior to the ash-flow eruptions, and similar lava eruptions continued within and adjacent to the calderas during the period of more silicic explosive volcanism. Exposed calderas vary in size from 10 to 75 km in maximum dimension; the largest calderas are associated with the most voluminous eruptions.

  1. Mantle flow geometry from ridge to trench beneath the Gorda-Juan de Fuca plate system

    NASA Astrophysics Data System (ADS)

    Martin-Short, Robert; Allen, Richard M.; Bastow, Ian D.; Totten, Eoghan; Richards, Mark A.

    2015-12-01

    Tectonic plates are underlain by a low-viscosity mantle layer, the asthenosphere. Asthenospheric flow may be induced by the overriding plate or by deeper mantle convection. Shear strain due to this flow can be inferred using the directional dependence of seismic wave speeds--seismic anisotropy. However, isolation of asthenospheric signals is challenging; most seismometers are located on continents, whose complex structure influences the seismic waves en route to the surface. The Cascadia Initiative, an offshore seismometer deployment in the US Pacific Northwest, offers the opportunity to analyse seismic data recorded on simpler oceanic lithosphere. Here we use measurements of seismic anisotropy across the Juan de Fuca and Gorda plates to reconstruct patterns of asthenospheric mantle shear flow from the Juan de Fuca mid-ocean ridge to the Cascadia subduction zone trench. We find that the direction of fastest seismic wave motion rotates with increasing distance from the mid-ocean ridge to become aligned with the direction of motion of the Juan de Fuca Plate, implying that this plate influences mantle flow. In contrast, asthenospheric mantle flow beneath the Gorda Plate does not align with Gorda Plate motion and instead aligns with the neighbouring Pacific Plate motion. These results show that asthenospheric flow beneath the small, slow-moving Gorda Plate is controlled largely by advection due to the much larger, faster-moving Pacific Plate.

  2. Assessing climate variability effects on dengue incidence in San Juan, Puerto Rico.

    PubMed

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E; Otis, Daniel; McCarthy, Matthew J; Peña-Orellana, Marisol

    2014-09-11

    We test the hypothesis that climate and environmental conditions are becoming favorable for dengue transmission in San Juan, Puerto Rico. Sea Level Pressure (SLP), Mean Sea Level (MSL), Wind, Sea Surface Temperature (SST), Air Surface Temperature (AST), Rainfall, and confirmed dengue cases were analyzed. We evaluated the dengue incidence and environmental data with Principal Component Analysis, Pearson correlation coefficient, Mann-Kendall trend test and logistic regressions. Results indicated that dry days are increasing and wet days are decreasing. MSL is increasing, posing higher risk of dengue as the perimeter of the San Juan Bay estuary expands and shorelines move inland. Warming is evident with both SST and AST. Maximum and minimum air surface temperature extremes have increased. Between 1992 and 2011, dengue transmission increased by a factor of 3.4 (95% CI: 1.9-6.1) for each 1 °C increase in SST. For the period 2007-2011 alone, dengue incidence reached a factor of 5.2 (95% CI: 1.9-13.9) for each 1 °C increase in SST. Teenagers are consistently the age group that suffers the most infections in San Juan. Results help understand possible impacts of different climate change scenarios in planning for social adaptation and public health interventions.

  3. Oil-bearing sediments beneath San Juan volcanics - Colorado's newest frontier

    SciTech Connect

    Gries, R.R.

    1985-05-01

    During the Tertiary, the western part of the northern Sange de Cristo Range dropped 16,000 ft (4877 m) to become what is now known as the San Luis basin. The foreland basin formerly adjacent to and west of the range remained intact but was subsequently concealed by 10,000 ft (3048 m) of volcanic deposits. The existence of this concealed basin, a northeastern arm of the San Juan basin, was first suggested by Vincent Kelly who named it the San Juan sag. Oil, which was generated in the underlying Mancos Shale, migrated upward into vesicles and fractures in volcanic rocks. In at least two places, oil is currently seeping onto the volcanic surface or into overlying soil. These oil occurrences encouraged geologic and geophysical exploration and have led to confirmation by drilling that the basin exists. Porous reservoirs in both tertiary sedimentary rocks and volcanic rocks overlie a 2000 ft (610 m) Cretaceous Mancos Shale source rock. Within the Mancos Shale are fractured reservoirs, volcanic sills that have reservoir potential where fractured or porous, and stray sandstones. The Dakota Formation underlies the Mancos Shale and is about 200 ft (61 m) thick in this area. In addition, the Jurassic section has potential for source rocks in the Todilto Formation and reservoir rocks in the Entrada and Junction Creek Sandstones. The San Juan sag, a newly discovered basin of 2600 miS (6734 kmS) is a frontier for Colorado oil and gas exploration.

  4. Transport of surface waters from the Juan de Fuca eddy region to the Washington coast

    NASA Astrophysics Data System (ADS)

    MacFadyen, Amoreena; Hickey, Barbara M.; Foreman, Michael G. G.

    2005-10-01

    A seasonal cold eddy located off the mouth of the Strait of Juan de Fuca has been implicated as an initiation site for toxic HABs affecting the Washington coast. To investigate the fate of eddy waters, a diagnostic finite element circulation model was developed for this region and the northern Washington shelf. The model was based on hydrographic data from several cruises in the summer of 1998, a year in which record levels of toxin were measured in razor clams at Washington beaches. Additional model forcing included tides and surface wind stress typical of fair weather/upwelling conditions or fall storms. The model showed strong retention in the eddy and a preferred southeastward trajectory for model drifters leaving the eddy. ARGOS-tracked drifters released in the vicinity of the eddy in the summers of 2001 through 2003 were consistent with model results generated with 1998 data demonstrating the robust nature of the large-scale currents in this region. Model and true drifter results show that the Juan de Fuca eddy is an important source region for PNW shelf waters. Furthermore, both model and true drifters moved onshore during storms suggesting that surface waters of the Juan de Fuca eddy can impact the Washington coast.

  5. Juan de Fuca slab geometry and its relation to Wadati-Benioff zone seismicity

    USGS Publications Warehouse

    McCrory, Patricia A.; Blair, J. Luke; Waldhause, Felix; Oppenheimer, David H.

    2012-01-01

    A new model of the subducted Juan de Fuca plate beneath western North America allows first-order correlations between the occurrence of Wadati-Benioff zone earthquakes and slab geometry, temperature, and hydration state. The geo-referenced 3D model, constructed from weighted control points, integrates depth information from earthquake locations and regional seismic velocity studies. We use the model to separate earthquakes that occur in the Cascadia forearc from those that occur within the underlying Juan de Fuca plate and thereby reveal previously obscured details regarding the spatial distribution of earthquakes. Seismicity within the slab is most prevalent where the slab is warped beneath northwestern California and western Washington suggesting that slab flexure, in addition to expected metamorphic dehydration processes, promotes earthquake occurrence within the subducted oceanic plate. Earthquake patterns beneath western Vancouver Island are consistent with slab dehydration processes. Conversely, the lack of slab earthquakes beneath western Oregon is consistent with an anhydrous slab. Double-differenced relocated seismicity resolves a double seismic zone within the slab beneath northwestern California that strongly constrains the location of the plate interface and delineates a cluster of seismicity 10 km above the surface that includes the 1992 M7.1 Mendocino earthquake. We infer that this earthquake ruptured a surface within the Cascadia accretionary margin above the Juan de Fuca plate. We further speculate that this earthquake is associated with a detached fragment of former Farallon plate. Other subsurface tectonic elements within the forearc may have the potential to generate similar damaging earthquakes.

  6. Fission-track dating of the tectonic development of the San Juan Islands, Washington.

    USGS Publications Warehouse

    Johnson, S.Y.; Zimmerman, R.A.; Naeser, C.W.; Whetten, J.T.

    1986-01-01

    Previous geological studies have indicated that the major thrusting event in the San Juan Islands was of late-early to late Cretaceous age. Geochronological data are consistent with these prior inferences and confirm that thrusting occurred between approx 105 and 75 m.y. Reset zircon fission-track dates indicate the possible presence of a reversed geothermal gradient in the Decatur terrain, the uppermost preserved thrust plate. If present, this gradient was probably produced by conductive heating, and possibly by shear heating associated with a now-eroded overlying thrust plate and thrust fault. Thrusting in the southern San Juan Islands was accompanied by uplift and resetting of apatite dates. The Haro formation, the Spieden group, and their basement (probably the Wrangellia terrain) did not experience this uplift and probably acted as a 'backstop' to thrusting. Uplift of the southern San Juan Islands was, therefore, probably mainly accommodated on the Haro fault. The Nanaimo basin formed in the foreland of this advancing thrust system, probably as a response to thrust-related loading. Eastern exposures of the Nanaimo group were uplifted prior to deposition of the Middle and Upper Eocene Padden member of the Chucknaut formation, perhaps along a reactivated Haro fault system. -J.M.H.

  7. Sediment-bound trace metals in Golfe-Juan Bay, northwestern Mediterranean: Distribution, availability and toxicity.

    PubMed

    Tiquio, Ma Gregoria Joanne; Hurel, Charlotte; Marmier, Nicolas; Taneez, Mehwish; Andral, Bruno; Jordan, Norbert; Francour, Patrice

    2017-03-18

    The concentration, potential mobility, cation exchange capacity and toxicity of eight sediment-bound metals in Golfe-Juan Bay, France were examined. Results revealed significant spatial gradient of metal contamination along Golfe-Juan coast. The distribution and concentration of the metals appear to be influenced by the geochemical properties of the sediment, proximity to anthropogenic sources and general water circulation in the bay. The portion of trace metals found in the exchangeable, carbonate, oxidizable and reducible fractions of the sediment constitute 31%-58% of the total sediment-bound trace metal content, suggesting significant potential for remobilization of metals into the water column. Pb and Ni content of the sediment exceed the limits of the French marine sediment quality. Whole sediment extracts showed acute toxicity to marine rotifers. This study concludes that monitoring and management of sediment-bound trace metals in Golfe-Juan Bay are important so as not to underestimate their availability and risk to the marine ecosystems.

  8. The San Juan Canyon, southeastern Utah: A geographic and hydrographic reconnaissance

    USGS Publications Warehouse

    Miser, Hugh D.

    1924-01-01

    This report, which describes the San Juan Canyon, San Juan River and the tributary streams and the geography and to some extent the geology of the region, presents information obtained by me during the descent of the river with the Trimble party in 1921. The exploration of the canyon, which was financed jointly by the United States Geological Survey and the Southern California Edison Co., had as its primary object the mapping and study of the San Juan in connection with proposed power and storage projects along this and Colorado rivers.1 The exploration party was headed by K. W. Thimble, topographic engineer of the United States Geological Survey. Other members of the party were Robert N. Allen, Los Angeles, Calif., recorder; H. E. Blake, jr., Monticello, Utah, and Hugh Hyde, Salt Lake City, Utah, rodmen; Bert Loper, Green River, Utah, boatman; Heber Christensen, Moab, Utah, cook; and H. D. Miser, geologist. Wesley Oliver, of Mexican Hat, Utah, served as packer for the party and brought mail and provisions by pack train twice a month to specified accessible places west of Goodridge.

  9. Ab initio ro-vibronic spectroscopy of SiCCl (X{sup ~2}Π)

    SciTech Connect

    Brites, Vincent; Mitrushchenkov, Alexander O.; Léonard, Céline; Peterson, Kirk A.

    2014-07-21

    The full dimensional potential energy surfaces of the {sup 2}A{sup ′} and {sup 2}A{sup ′′} electronic components of X{sup ~2}Π SiCCl have been computed using the explicitly correlated coupled cluster method, UCCSD(T)-F12b, combined with a composite approach taking into account basis set incompleteness, core-valence correlation, scalar relativity, and higher order excitations. The spin-orbit and dipole moment surfaces have also been computed ab initio. The ro-vibronic energy levels and absorption spectrum at 5 K have been determined from variational calculations. The influence of each correction on the fundamental frequencies is discussed. An assignment is proposed for bands observed in the LIF experiment of Smith et al. [J. Chem. Phys. 117, 6446 (2002)]. The overall agreement between the experimental and calculated ro-vibronic levels is better than 7 cm{sup −1} which is comparable with the 10–20 cm{sup −1} resolution of the emission spectrum.

  10. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis.

    PubMed Central

    Fitzgerald, T J

    1992-01-01

    Cefetamet pivoxil (Ro 15-8075) is a newly developed, expanded-spectrum cephalosporin that is orally active. In vitro, the active form, cefetamet (Ro 15-8074), at a concentration of 0.05 micrograms/ml killed and lysed Treponema pallidum. Rabbit serum did not diminish its effectiveness. The antibiotic rapidly entered the circulation following intramuscular injection into rabbits, attaining its highest levels of 24 to 37 micrograms/ml within 10 to 30 min. Animals were infected intradermally with T. pallidum and then treated with different doses of cefetamet. Accelerated healing was detected following treatment with 15 and 30 mg/kg of body weight. The antibiotic was also effective in killing organisms that had disseminated to distant tissues. In three separate sets of experiments, rabbits were infected with treponemes and then treated with cefetamet intramuscularly at 1, 15, or 30 mg/kg as follows: (i) after lesions had just become clinically apparent, (ii) after lesions were enlarged and well developed, or (iii) prior to the appearance of clinical lesions. Antibiotic effectiveness was determined by sacrificing the animals 1 week after antibiotic treatment and examining splenic tissue for residual, disseminated treponemes. Cefetamet was treponemicidal in all three situations. Maximum effects occurred when the antibiotic was injected before lesions had become clinically apparent (incubation period). These results suggest that cefetamet pivoxil might be useful for treating syphilitic infections. PMID:1622168

  11. Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases

    PubMed Central

    Navarro-Gonzálvez, José Antonio; Rodríguez-Lozano, Beatriz

    2017-01-01

    The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time. PMID:28210273

  12. Overlap of Doxycycline Fluorescence with that of the Redox-Sensitive Intracellular Reporter roGFP.

    PubMed

    Khader, Heba; Solodushko, Victor; Al-Mehdi, Abu Bakr; Audia, Jonathon; Fouty, Brian

    2014-03-01

    Tetracycline-inducible systems allow for either suppression or induction of transgene expression to facilitate studies of cell physiology. Doxycycline is a preferred inducer for these gene expression systems due to its membrane permeability; however, the heterocyclic structure of doxycycline exhibits fluorogenic properties that can potentially bias measurement of other fluorochromes. Thus the simultaneous use of tetracycline-inducible systems and fluorescent proteins as reporter genes or as intracellular biosensors may lead to potentially confounding results. Herein, using cells which co-express the ratiometric redox sensitive intracellular reporter, roGFP, and a tetracycline-inducible reporter plasmid encoding the reporter gene, mCherry, as a model system, we describe the overlapping intracellular fluorescent signals between doxycycline and commonly used intracellular fluorescent probes. In our cells, the addition of doxycycline to cells caused a dose- and time-dependent increase in cell fluorescence with 405 nm excitation which overlapped with that of the oxidized configuration of roGFP. Incubating cells in concentrations of doxycycline less than 1 μg/mL and removing doxycycline from the media 60 min before performing experiments eliminated fluorescence interference while still maintaining maximal reporter transgene activation.

  13. RO concentrate minimization by electrodialysis: techno-economic analysis and environmental concerns.

    PubMed

    Zhang, Yang; Ghyselbrecht, Karel; Vanherpe, Ruben; Meesschaert, Boudewijn; Pinoy, Luc; Van der Bruggen, Bart

    2012-09-30

    This paper presents a systematic techno-economical analysis and an environmental impact evaluation of a reverse osmosis (RO) concentrate treatment process using electrodialysis (ED) in view of environmental management of brine discharges. The concentrate originates from a secondary effluent treated by RO. Without any treatment, the concentrate would have to be discharged; this is compared in this study to the costs and benefits of an effective treatment method in a pilot scale ED plant. A technical analysis was done both on lab scale and pilot scale for the determination of operational and maintenance costs for the ED installation at the required conditions of process performance and safety. Subsequently, an economical analysis was done to calculate the cost of the different parts of the ED system. It was shown that an operational cost of 0.19 EUR m(-3) can be achieved, assuming that the ED concentrate is to decarbonated at pH 6.0 to prevent membrane scaling. Finally, environmental impact issues were calculated and discussed for the overall system. Results imply that if renewable energy is applied for the ED power source, CO(2) emission from membrane processes can be much less than from the conventional treatment methods.

  14. Simultaneous manipulation and observation of multiple ro-vibrational eigenstates in solid para-hydrogen

    NASA Astrophysics Data System (ADS)

    Katsuki, Hiroyuki; Ohmori, Kenji

    2016-09-01

    We have experimentally performed the coherent control of delocalized ro-vibrational wave packets (RVWs) of solid para-hydrogen (p-H2) by the wave packet interferometry (WPI) combined with coherent anti-Stokes Raman scattering (CARS). RVWs of solid p-H2 are delocalized in the crystal, and the wave function with wave vector k ˜ 0 is selectively excited via the stimulated Raman process. We have excited the RVW twice by a pair of femtosecond laser pulses with delay controlled by a stabilized Michelson interferometer. Using a broad-band laser pulse, multiple ro-vibrational states can be excited simultaneously. We have observed the time-dependent Ramsey fringe spectra as a function of the inter-pulse delay by a spectrally resolved CARS technique using a narrow-band probe pulse, resolving the different intermediate states. Due to the different fringe oscillation periods among those intermediate states, we can manipulate their amplitude ratio by tuning the inter-pulse delay on the sub-femtosecond time scale. The state-selective manipulation and detection of the CARS signal combined with the WPI is a general and efficient protocol for the control of the interference of multiple quantum states in various quantum systems.

  15. Isolated anti-Ro/SSA thrombocytopenia: a rare feature of neonatal lupus.

    PubMed

    Ayadi, Imene Dahmane; Ben Hamida, Emira; Boukhris, Mohamed Riadh; Bezzine, Ahlem; Chaouachi, Sihem; Marrakchi, Zahra

    2015-01-01

    We report a rare case of isolated thrombocytopenia related to anti-Ro/SSA antibodies. The mother was followed for unlabeled familial thrombocytopenia. The mother had positive anti-Ro/SSA antibodies. She was asymptomatic without skin lesions or other criteria neither of systemic lupus erythematosus nor other connective tissue disease. Pregnancy was uneventful. The postnatal examination was normal. On the first day of life, blood cells count showed thrombocytopenia at 40 x 10(9)/L. Within the second day of life, platelet level dropped to 20 x 10(9)/L. The management of thrombocytopenia included platelet transfusion and human immunoglobulin infusion. On the fifth day of life, there has been a drop in platelet count to 10 x 10(9)/L requiring renewed platelet transfusion and human immunoglobulin infusion. On the 10(th) of life platelets rate was stable around 60 x 10(9)/L. The infant had no evidence of cardiac, dermatologic or hepatobilary involvement initially or throughout follow up.

  16. Tailoring the structure of thin film nanocomposite membranes to achieve seawater RO membrane performance.

    PubMed

    Lind, Mary Laura; Eumine Suk, Daniel; Nguyen, The-Vinh; Hoek, Eric M V

    2010-11-01

    Herein we report on the formation and characterization of pure polyamide thin film composite (TFC) and zeolite-polyamide thin film nanocomposite (TFN) reverse osmosis (RO) membranes. Four different physical-chemical post-treatment combinations were applied after the interfacial polymerization reaction to change the molecular structure of polyamide and zeolite-polyamide thin films. Both TFC and TFN hand-cast membranes were more permeable, hydrophilic, and rough than a commercial seawater RO membrane. Salt rejection by TFN membranes was consistently below that of hand-cast TFC membranes; however, two TFN membranes exhibited 32 g/L NaCl rejections above 99.4%, which was better than the commercial membrane under the test conditions employed. The nearly defect-free TFN films that produced such high rejections were achieved only with wet curing, regardless of other post-treatments. Polyamide films formed in the presence of zeolite nanoparticles were less cross-linked than similarly cast pure polyamide films. At the very low nanoparticle loadings evaluated, differences between pure polyamide and zeolite-polyamide membrane water and salt permeability correlated weakly with extent of cross-linking of the polyamide film, which suggests that defects and molecular-sieving largely govern transport through zeolite-polyamide thin film nanocomposite membranes.

  17. Transiting exoplanets from the CoRoT space mission. XI. CoRoT-8b: a hot and dense sub-Saturn around a K1 dwarf

    NASA Astrophysics Data System (ADS)

    Bordé, P.; Bouchy, F.; Deleuil, M.; Cabrera, J.; Jorda, L.; Lovis, C.; Csizmadia, S.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Benz, W.; Bonomo, A. S.; Bruntt, H.; Carone, L.; Carpano, S.; Deeg, H.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E.; Guillot, T.; Guterman, P.; Hatzes, A.; Havel, M.; Hébrard, G.; Lammer, H.; Léger, A.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pepe, F.; Ollivier, M.; Queloz, D.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.; Tingley, B.; Udry, S.; Weingrill, J.; Wuchterl, G.

    2010-09-01

    Aims: We report the discovery of CoRoT-8b, a dense small Saturn-class exoplanet that orbits a K1 dwarf in 6.2 days, and we derive its orbital parameters, mass, and radius. Methods: We analyzed two complementary data sets: the photometric transit curve of CoRoT-8b as measured by CoRoT and the radial velocity curve of CoRoT-8 as measured by the HARPS spectrometer. Results: We find that CoRoT-8b is on a circular orbit with a semi-major axis of 0.063 ± 0.001 AU. It has a radius of 0.57 ± 0.02 RJ, a mass of 0.22 ± 0.03 MJ, and therefore a mean density of 1.6 ± 0.1 g cm-3. Conclusions: With 67% of the size of Saturn and 72% of its mass, CoRoT-8b has a density comparable to that of Neptune (1.76 g cm-3). We estimate its content in heavy elements to be 47-63 {M}_⊕, and the mass of its hydrogen-helium envelope to be 7-23 {M}_⊕. At 0.063 AU, the thermal loss of hydrogen of CoRoT-8b should be no more than 0.1% over an assumed integrated lifetime of 3 Ga. Observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07B.MOUT), and the HARPS spectrograph at ESO La Silla Observatory (081.C-0388 and 083.C-0186). The CoRoT space mission, launched on December 27, 2006, has been developed and is operated by the CNES with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.Both data sets are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/520/A66

  18. Divergent Ridge Features on the Juan de Fuca and Gorda Ridges

    NASA Astrophysics Data System (ADS)

    Eaton, M. E.; Sautter, L.; Steele, M.

    2014-12-01

    Multibeam data collected using a Kongsberg EM122 sonar system on the NOAA ship R/V Marcus G. Langseth led by chief scientist Douglas Toomey (University of Oregon) in 2009 and with a Simrad EM302 sonar system on two NOAA ship Okeanos Explorer cruises led by chief scientists James Gardner (University of New Hampshire) and Catalina Martinez (University of Rhode Island) in 2009 show the morphology of the Juan de Fuca and Gorda Ridges, as well as the Blanco and Mendocino Fracture Zones. These ridges and fracture zones comprise the divergent plate boundary of the eastern edge of the Pacific Plate and the western edges of the Juan de Fuca and Gorda Plates. Both plates are being subducted beneath the western edge of the North American Plate. CARIS HIPS 8.1 software was used to process the multibeam data and create bathymetric images. The ridge axes, located off the coast of Washington and Oregon (USA) adjacent to the Cascadia Basin, indicate obvious signs of spreading, due to the series of faults and rocky ridges aligned parallel to the plate boundaries. Fault and ridge orientations are used to compare the direction of seafloor spreading, and indicate that both the Juan de Fuca Plate and Gorda Plate are spreading in a southeastern direction. Younger ridges from the Gorda Ridge system mapped in the study run parallel to the boundary, however older ridges do not show the same orientation, indicating a change in spreading direction. The presence of hydrothermal vents along the Juan de Fuca Ridge is also evidence of the active boundary, as the vent chimneys are composed of minerals and metals precipitated from the hot water heated by magma from beneath the spreading seafloor. In this study, the data are used to compare and contrast earthquake seismicity and ridge morphologies at a depth range of approximately 762 to 2134 meters. The diverging Pacific, Juan de Fuca, and Gorda Plates along with the San Andreas Fault have potential to increase seismic and volcanic activity around

  19. A Single-Chip Speech Dialogue Module and Its Evaluation on a Personal Robot, PaPeRo-Mini

    NASA Astrophysics Data System (ADS)

    Sato, Miki; Iwasawa, Toru; Sugiyama, Akihiko; Nishizawa, Toshihiro; Takano, Yosuke

    This paper presents a single-chip speech dialogue module and its evaluation on a personal robot. This module is implemented on an application processor that was developed primarily for mobile phones to provide a compact size, low power-consumption, and low cost. It performs speech recognition with preprocessing functions such as direction-of-arrival (DOA) estimation, noise cancellation, beamforming with an array of microphones, and echo cancellation. Text-to-speech (TTS) conversion is also equipped with. Evaluation results obtained on a new personal robot, PaPeRo-mini, which is a scale-down version of PaPeRo, demonstrate an 85% correct rate in DOA estimation, and as much as 54% and 30% higher speech recognition rates in noisy environments and during robot utterances, respectively. These results are shown to be comparable to those obtained by PaPeRo.

  20. Computing Ro in a population with heterogeneity in sexual activity and proportionate mixing using a STM-solver

    NASA Astrophysics Data System (ADS)

    Gutierrez A., Natalia A.

    2014-06-01

    A model to determinate the reproductive basic number, detonated Ro, for the case of population with heterogeneity in sexual activity and proportionate mixing is solved using computer algebra and SMT solvers. Specifically Maple and Z3 were used. The code for the solution of the model was written in Z3-Python, but it can also be played by Z3-SMT-Lib. Ro represents an algebraic synthesis of every epidemiological parameter. Numerical simulations were done to prove the effectiveness of the model and the code. The algebraic structure of Ro suggests the possible control measurements that should be implemented to avoid the propagation of the sexual transmitted diseases. The obtained results are important on the computational epidemiology field. As a future investigation, it is suggested to apply the STM solvers to analyze models for other kinds of epidemic diseases.

  1. Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.

    PubMed

    Thiébot, M H; Childs, M; Soubrié, P; Simon, P

    1983-03-18

    The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding for food, reflect the anxiolytic property of benzodiazepines. The amnesic-like effect of diazepam was also investigated. Ro 15-1788 (in doses ranging from 4 to 16 mg/kg p.o.) completely reversed diazepam (2 mg/kg)-induced release of behavior in both punishment and non-reward procedures. In contrast, Ro 15-1788 reduced but did not completely abolish diazepam-induced amnesia. These data suggest that the anticonflict and anti-frustration effects of benzodiazepines probably involve similar receptor types which nevertheless differ from those chiefly implicated in the amnesic-like activity of benzodiazepines.

  2. Benzodiazepine receptor inverse agonists. beta. -CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice

    SciTech Connect

    Belzung, C.; Misslin, R.; Vogel, E.

    1988-01-01

    The antagonistic effects of the benzodiazepine receptor inverse agonist ..beta..-CCM and of the partial inverse agonist RO 15-3505 on the anxiolytic properties of ethanol in mice confronted with a light/dark choice procedure and with the staircase test were investigated. Both drugs reversed the effects of ethanol on some of the behavioral parameters, but ..beta..-CCM alone elicited anxiogenic intrinsic effects. RO-3505 induced seizures in mice treated with a subconvulsant dose of pentylenetetrazole, the most efficient doses being 3 and 6 mg/kg. These data indicate that ..beta..-CCM and RO 15-3505 can reverse some of the anxiolytic effects of ethanol, acting probably to oppose GABA function via the benzodiazepine receptor.

  3. Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist

    SciTech Connect

    Akech, Jacqueline; Roy, Somdutta Sinha; Das, Salil K. . E-mail: sdas@mmc.edu

    2005-07-22

    Changes in phospholipid and fatty acid profile are hallmarks of cancer progression. Increase in peripheral benzodiazepine receptor expression has been implicated in breast cancer. The benzodiazepine, Ro5-4864, increases cell proliferation in some breast cancer cell lines. Biosynthesis of phosphatidylcholine (PC) has been identified as a marker for cells proliferating at high rates. Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC. We have addressed here whether Ro5-4864 facilitates some cancer causing mechanisms in breast cancer. We report that cell proliferation increases exponentially in aggressive breast cancer cell lines 11-9-1-4 and BT-549 when treated with nanomolar concentrations of Ro5-4864. This increase is seen within 24 h of treatment, consistent with the cell doubling time in these cells. Ro5-4864 also upregulates c-fos expression in breast cancer cell lines 11-9-1-4 and BT-549, while expression in non-tumorigenic cell line MCF-12A was either basal or slightly downregulated. We further examined the expression of the CPT gene in breast cancer (11-9-1-4, BT-549) and non-tumorigenic cell lines (MCF-12A, MCF-12F). We found that the CPT gene is overexpressed in breast cancer cell lines compared to the non-tumorigenic cell lines. Furthermore, the activity of CPT in forming PC is increased in the breast cancer cell lines cultured for 24 h. Additionally, we examined the CPT activity in the presence of nanomolar concentrations of Ro5-4864. Biosynthesis of PC was increased in breast cancer cell lines upon treatment. We therefore propose that Ro5-4864 facilitates PC formation, a process important in membrane biogenesis for proliferating cells.

  4. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

    PubMed Central

    Blandin, Gaetan; Verliefde, Arne R.D.; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-01-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling. PMID:27376337

  5. Efficiently Combining Water Reuse and Desalination through Forward Osmosis-Reverse Osmosis (FO-RO) Hybrids: A Critical Review.

    PubMed

    Blandin, Gaetan; Verliefde, Arne R D; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-07-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  6. The PA endonuclease inhibitor RO-7 protects mice from lethal challenge with influenza A or B viruses.

    PubMed

    Jones, Jeremy C; Marathe, Bindumadhav M; Vogel, Peter; Gasser, Rodolfo; Najera, Isabel; Govorkova, Elena A

    2017-02-13

    Current influenza treatment relies on a single class of antiviral drugs, the neuraminidase inhibitors (NAIs), raising concern over the potential emergence of resistant variants and necessitating the development of novel drugs. In recent years, investigational inhibitors targeting the endonuclease activity of the influenza acidic polymerase (PA) protein have yielded encouraging results, although there are only limited data on their in vivo efficacy. Here, we examined the antiviral potential of the PA endonuclease inhibitor RO-7 in prophylactic and therapeutic regimens in BALB/c mice inoculated with influenza A/California/04/2009 (H1N1)pdm09 or B/Brisbane/60/2008 viruses, which represent currently circulating antigenic variants. RO-7 was administered to mice intraperitoneally twice daily at dosages of 6, 15, or 30 mg/kg/day for 5 days, starting 4 h before or 24 or 48 h after virus inoculation, and showed no adverse effects. Prophylactic administration completely protected mice from lethal infection by influenza A or B virus. The level of therapeutic protection conferred depended upon the time of treatment initiation and RO-7 dosage, resulting in 60%-100% and 80%-100% survival with influenza A and B viruses, respectively. RO-7 treatment significantly decreased virus titers in the lung and lessened the extent and severity of lung damage. No PA endonuclease-inhibitor resistance was observed in viruses isolated from lungs of RO-7-treated mice, and the viruses remained susceptible to the drug at nanomolar concentrations in phenotypic assays. These in vivo efficacy results further highlight the potential of RO-7 for development as antiviral therapy for influenza A and B virus infections.

  7. Lichen scléro-atrophique extra-génital: à propos d’un cas

    PubMed Central

    Zemmez, Youssef; Amraoui, Mohammed El; Bouhamidi, Ahmed; Azhari, Jaouad El; Ismaili, Nadia; Benzekri, Laila; Meziane, Mariame; Hassam, Badreddine; Senouci, Karima

    2016-01-01

    Le lichen scléro-atrophique est une dermatose inflammatoire d'évolution chronique, avec un tropisme particulier pour les muqueuses génitales externes, l'atteinte cutanée isolée reste rare. Nous rapportons un cas de lichen scléro-atrophique chez une femme avec atteinte purement cutanée soulignant ainsi l'intérêt d'évoquer ce diagnostic en absence d'une atteinte génitale évidente. PMID:28292152

  8. Juan de Fuca Plate Ridge-to-Trench Experiment: initial results from active source seismic imaging of the Juan de Fuca plate and Cascadia fore-arc (Invited)

    NASA Astrophysics Data System (ADS)

    Carbotte, S. M.; Canales, J.; Carton, H. D.; Han, S.; Gibson, J. C.; Janiszewski, H. A.; Horning, G.; Nedimovic, M. R.; Abers, G. A.; Trehu, A. M.

    2013-12-01

    Active source seismic data were acquired during the Juan de Fuca Ridge-to-Trench experiment (June-July 2012) to characterize the evolution and structure of the Juan de Fuca plate from formation at the ridge, through evolution in the plate interior, to subduction at the Cascadia trench. The survey provides plate-scale images of the sediments, crust, and shallowest mantle along two ridge-perpendicular transects, one extending from Axial seamount to the Oregon margin near Hydrate Ridge and the other from near Endeavour segment to Grays Harbor offshore Washington. In addition, a 450 km long trench-parallel line ~10 km seaward of the Cascadia deformation front was acquired to characterize variations in plate structure along the margin. Coincident long-streamer (8 km) multi-channel seismic (MCS) and wide-angle ocean bottom seismometer (OBS) data were collected along each transect. Using these data, our current investigations focus on the properties of the thick sediment blanket covering the Juan de Fuca plate and evidence for fluid flow at the deformation front, crustal structure within the plate interior and near the deformation front, and tracking the downgoing plate beneath the margin. Highlights include the discovery of numerous pockmarks on the seafloor providing evidence of active fluid flow up to 60 km west of the deformation front. Along the Oregon transect, a bright decollement horizon is imaged at ~1sec twtt above basement whereas at the Washington margin, protothrusts of the deformation front reach to the top of the oceanic crust. Variations in sediment properties are documented within the margin-parallel transect with changes in the stratigraphic level of decollement. While crustal thickness is quite uniform along the margin (~ 6 km), variations in crustal reflectivity and in shallowest mantle velocities are observed over ~30-50 km length scales that could be related to structural variations in the Cascadia subduction zone. Further landward, the top of the

  9. Transiting exoplanets from the CoRoT space mission. XXI. CoRoT-19b: a low density planet orbiting an old inactive F9V-star

    NASA Astrophysics Data System (ADS)

    Guenther, E. W.; Díaz, R. F.; Gazzano, J.-C.; Mazeh, T.; Rouan, D.; Gibson, N.; Csizmadia, Sz.; Aigrain, S.; Alonso, R.; Almenara, J. M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Cabrera, J.; Carone, L.; Carpano, S.; Cavarroc, C.; Deeg, H. J.; Deleuil, M.; Dreizler, S.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Lammer, H.; Léger, A.; Moutou, C.; Nortmann, L.; Ollivier, M.; Ofir, A.; Pasternacki, Th.; Pätzold, M.; Parviainen, H.; Queloz, D.; Rauer, H.; Samuel, B.; Santerne, A.; Schneider, J.; Tal-Or, L.; Tingley, B.; Weingrill, J.; Wuchterl, G.

    2012-01-01

    Context. Observations of transiting extrasolar planets are of key importance to our understanding of planets because their mass, radius, and mass density can be determined. These measurements indicate that planets of similar mass can have very different radii. For low-density planets, it is generally assumed that they are inflated owing to their proximity to the host-star. To determine the causes of this inflation, it is necessary to obtain a statistically significant sample of planets with precisely measured masses and radii. Aims: The CoRoT space mission allows us to achieve a very high photometric accuracy. By combining CoRoT data with high-precision radial velocity measurements, we derive precise planetary radii and masses. We report the discovery of CoRoT-19b, a gas-giant planet transiting an old, inactive F9V-type star with a period of four days. Methods: After excluding alternative physical configurations mimicking a planetary transit signal, we determine the radius and mass of the planet by combining CoRoT photometry with high-resolution spectroscopy obtained with the echelle spectrographs SOPHIE, HARPS, FIES, and SANDIFORD. To improve the precision of its ephemeris and the epoch, we observed additional transits with the TRAPPIST and Euler telescopes. Using HARPS spectra obtained during the transit, we then determine the projected angle between the spin of the star and the orbit of the planet. Results: We find that the host star of CoRoT-19b is an inactive F9V-type star close to the end of its main-sequence life. The host star has a mass M∗ = 1.21 ± 0.05 M⊙ and radius R∗ = 1.65 ± 0.04 R⊙. The planet has a mass of MP = 1.11 ± 0.06 MJup and radius of RP = 1.29 ± 0.03 RJup. The resulting bulk density is only ρ = 0.71 ± 0.06 g cm-3, which is much lower than that for Jupiter. Conclusions: The exoplanet CoRoT-19b is an example of a giant planet of almost the same mass as Jupiter but a ≈30% larger radius. The CoRoT space mission, launched on

  10. 78 FR 37788 - In the Matter of: Juan Ricardo Puente-Paez, Inmate Number #05086-379, FCI McDowell, Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Bureau of Industry and Security In the Matter of: Juan Ricardo Puente-Paez, Inmate Number 05086-379, FCI..., Juan Ricardo Puente-Paez (``Puente-Paez'') was convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). Specifically, Puente-Paez was convicted...

  11. Estimates of ground-water recharge from precipitation to glacial-deposit and bedrock aquifers on Lopez, San Juan, Orcas, and Shaw islands, San Juan County, Washington

    USGS Publications Warehouse

    Orr, Laura A.; Bauer, Henry H.; Wayenberg, Judith A.

    2002-01-01

    An important source of fresh water on Lopez, San Juan, Orcas, and Shaw Islands in San Juan County off the northwestern coast of Washington is glacial-deposit and bedrock aquifers. Two methods were used to estimate recharge from precipitation to the water tables on the islands. A daily near-surface water-balance method, the Deep Percolation Model (DPM), was used to simulate water budgets for the period October 1, 1996, through September 30, 1998 (water years 1997-98) for six small drainage basins?three on Lopez Island and one each on San Juan, Orcas, and Shaw Islands. The calibrated soil and subsoil parameters from the DPM for each small basin were then used in island-wide applications of the DPM where the direct runoff component (which is not available on an island-wide basis) was simulated, rather than input, and calibration was not required. A spatial distribution of annual recharge was simulated for each island, with island averages of: Lopez Island, 2.49 inches per year; San Juan Island, 1.99 inches per year; Orcas Island, 1.46 inches per year; and Shaw Island, 1.44 inches per year.A chloride mass-balance method that requires measurements of atmospheric chloride deposition, precipitation, streamflow, and chloride concentrations in ground water was used to estimate recharge to the glacial-deposit aquifers of Lopez Island. Only average recharge could be estimated using this method rather than area-specific recharge. Average recharge for Lopez Island estimated by this method was only 0.63 inch per year. The range of chloride concentrations in ground-water samples from selected wells indicates that the average recharge in areas of glacial deposits is between 0.29 and 1.95 inches per year. Recharge simulated using the DPM for two drainage basins on Lopez Island overlain by glacial deposits are 2.76 and 2.64 inches per year. Sources of chloride in ground water other than from the atmosphere would cause the recharge estimated by the chloride mass-balance method to be

  12. Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

    PubMed Central

    2016-01-01

    The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antiandrogenic drug nilutamide. Building on the known SAR of this compound series, we now describe a number of analogs of 1 designed to maximize structural diversity guided by incorporation of substructures and functional groups known to diminish ligand–androgen receptor interactions. These analogs had calculated polar surface area (PSA), measured LogD7.4, aqueous kinetic solubility, and estimated plasma protein binding values in ranges predictive of good ADME profiles. The principal SAR insight was that the hydantoin core of 1 is required for high antischistosomal activity. We identified several compounds with high antischistosomal efficacy that were less antiandrogenic than 1. These data provide direction for the ongoing optimization of antischistosomal hydantoins. PMID:27933964

  13. High-efficiency optical coupling single-sideband modulation for OFDM-RoF-PON systems

    NASA Astrophysics Data System (ADS)

    Xue, Xuwei; Ji, Wei; Kang, Zhaoyuan; Huang, Kangrui; Li, Xiao

    2015-12-01

    We report on an OFDM-RoF-PON system based on novel optical coupling single-sideband (O-SSB) modulation for one wavelength carrying one baseband and two radio frequency (RF) signals. The impact of nonlinear distortion consisting of harmonic distortion (HD) and intermodulation distortion (IMD) in this system is theoretically investigated. Transmission over 0 km and 40 km of standard single mode fiber is successfully demonstrated and it is indicated that modulation index 0.6 is more adapted to O-SSB modulation. The error vector magnitude (EVM) of system based on O-SSB modulation after transmission over 40 km is <0.1. For O-SSB modulation, bit error rate (BER) after 40 km transmission is below forward error correction (FEC) limit of 10-3.

  14. Pharmacokinetics of Ro 03-8799 in mice bearing melanosarcoma: comparison with tumors without melanin

    SciTech Connect

    Laurent, F.; Canal, P.; Soula, G.

    1989-04-01

    The pharmacokinetics of Ro 03-8799 has been studied in melanic and non-melanic tumor bearing mice after iv administration of 150 mg/kg. The peak concentration in B16 melanosarcoma tumor reached 152 micrograms/g, that is 7.6-fold higher than the plasma concentration at the same time. This concentration is 3-times greater than that obtained in the tumor of mice bearing non-melanic sarcoma (DB16) or Lewis lung carcinoma (3LL). The exposure of B16 tumor (AUC) is respectively 15-times and 11-times higher than the 3LL and the DB16 ones. These experimental data confirm that this 2-nitro-imidazol compound has an important affinity for melanin and suggest that it might be used as a radiosensitizer for the treatment of malignant melanoma.

  15. Looking for planetary candidates in the CoRoT Long Run LRc10

    NASA Astrophysics Data System (ADS)

    Zannoni, A.; Borsa, F.; Poretti, E.; Lodato, G.; Rainer, M.; Frustagli, G.

    We analysed the public data of the CoRoT Long Run LRc10 looking for planetary candidates. In a first step we removed outliers and trends caused by stellar activity and instrumental problems. Then we applied the Box-fitting Least Squares (BLS) algorithm to detect periodic decreases in luminosity. From all the significative transit detections, we selected the ones that passed different checks. For the 7 planetary candidates found, we applied a new ``ad hoc'' normalization and fitted the orbital parameters, to verify their reliability. Using the stellar temperature information, we could estimate the dimensions that the candidates should have if confirmed. Our research method demonstrated to be sensitive to candidates with hypothetic dimension up to ˜3.5 REarth on stars of mag V≃14.

  16. Variational Calculations of Ro-Vibrational Energy Levels and Transition Intensities for Tetratomic Molecules

    NASA Technical Reports Server (NTRS)

    Schwenke, David W.; Langhoff, Stephen R. (Technical Monitor)

    1995-01-01

    A description is given of an algorithm for computing ro-vibrational energy levels for tetratomic molecules. The expressions required for evaluating transition intensities are also given. The variational principle is used to determine the energy levels and the kinetic energy operator is simple and evaluated exactly. The computational procedure is split up into the determination of one dimensional radial basis functions, the computation of a contracted rotational-bending basis, followed by a final variational step coupling all degrees of freedom. An angular basis is proposed whereby the rotational-bending contraction takes place in three steps. Angular matrix elements of the potential are evaluated by expansion in terms of a suitable basis and the angular integrals are given in a factorized form which simplifies their evaluation. The basis functions in the final variational step have the full permutation symmetries of the identical particles. Sample results are given for HCCH and BH3.

  17. Ro-vibrational averaging of the isotropic hyperfine coupling constant for the methyl radical

    SciTech Connect

    Adam, Ahmad Y.; Jensen, Per; Yachmenev, Andrey; Yurchenko, Sergei N.

    2015-12-28

    We present the first variational calculation of the isotropic hyperfine coupling constant of the carbon-13 atom in the CH{sub 3} radical for temperatures T = 0, 96, and 300 K. It is based on a newly calculated high level ab initio potential energy surface and hyperfine coupling constant surface of CH{sub 3} in the ground electronic state. The ro-vibrational energy levels, expectation values for the coupling constant, and its temperature dependence were calculated variationally by using the methods implemented in the computer program TROVE. Vibrational energies and vibrational and temperature effects for coupling constant are found to be in very good agreement with the available experimental data. We found, in agreement with previous studies, that the vibrational effects constitute about 44% of the constant’s equilibrium value, originating mainly from the large amplitude out-of-plane bending motion and that the temperature effects play a minor role.

  18. A hybrid ED/RO process for TDS reduction of produced waters

    SciTech Connect

    Tsai, S.P.; Datta, R.; Frank, J.R.

    1995-12-31

    Large volumes of produced waters are generated from natural gas production. In the United States the prevailing management practice for produced waters is deep well injection, but this practice is costly. Therefore minimizing the need for deep well injection is desirable. A major treatment issue for produced waters is the reduction of total dissolved solids (TDS), which consist mostly of inorganic salts. A hybrid electrodialysis/reverse-osmosis (ED/RO) treatment process is being developed to concentrate the salts in produced waters and thereby reduce the volume of brine that needs to be managed for disposal. The desalted water can be used beneficially or discharged. In this study, laboratory feasibility experiments were conducted by using produced waters from multiple sites. A novel-membrane configuration approach to prevent fouling and scale formation was developed and demonstrated. Results of laboratory experiments and plans for field demonstration are discussed.

  19. Constructing generalized Cesàro formulas for finite plane strains

    NASA Astrophysics Data System (ADS)

    Georgievskii, D. V.

    2014-05-01

    The problem of finding the displacement vector from a system of nonlinear differential equations which includes displacement gradient components is studied. Expressions on the right side of this system for certain parameter values have the kinematic sense of Lagrange and Euler finite strain tensors. The task is to construct generalized Cesàro formulas for finite strains. The construction of the solution consists of two stages (algebraic and differential), and the second is performed for space whose dimension is greater than or equal to two. An algorithm for the inversion of the original system is proposed, and analytical constructions for the case of two-dimensional space are performed. The problem is solved at the first (algebraic) stage, i.e., an exact analytical expression for the displacement vector components is derived through the known finite strain tensor and an unknown scalar function having the kinematic sense of rotation. Necessary conditions for the existence of this relationship are formulated.

  20. Doppler mapping of four roAp stars with anomalous lithium abundance

    NASA Astrophysics Data System (ADS)

    Polosukhina, N.; Shulyak, D.; Shavrina, A.; Lyashko, D.; Drake, N.; Glagolevsky, Y.; Kudryavtsev, D.; Smirnova, M.

    2014-11-01

    We present the first results from Doppler Imaging of two roAp stars, HD 12098 and HD 60435, that show strong and variable Li lines in their spectra. High-resolution spectra were obtained with the Russian 6-m BTA telescope, and with the HARPS and VLT/UVES instruments at ESO. We derived the surface abundance distribution of Li and Pr and analysed the correlation between the positions of the Li-abundance spots and magnetic field. We compare our results with Doppler Imaging mapping previously obtained for two CP2 stars, HD 83668 and HD 3980, and discuss the common properties of the locations of the ``Li spots'' on the surfaces of magnetic chemically peculiar A-type stars.

  1. The CoRoT and Kepler Revolution in Stellar Variability Studies

    NASA Astrophysics Data System (ADS)

    Degroote, Pieter; Debosscher, Jonas

    2012-04-01

    Space-based observations of variable stars have revolutionized the field of variability studies. Dedicated satellites such as the CoRoT and Kepler missions have duty cycles which are unachievable from the ground, and effectively solve many of the aliasing problems prevalent in ground-based observation campaigns. Moreover, the location above the Earth's atmosphere eliminates a major source of scatter prevalent in observations from the ground. These two major improvements in instrumentation have triggered significant increases in our knowledge of the stars, but in order to reap the full benefits they are also obliging the community to adopt more efficient techniques for handling, analysing and interpreting the vast amounts of new, high-precision data in an effective yet comprehensive manner. This workshop heard an outline of the history and development of asteroseismology, and descriptions of the two space missions (CoRoT and Kepler) which have been foremost in accelerating those recent developments. Informal discussions on numerous points peppered the proceedings, and involved the whole audience at times. The conclusions which the workshop reached have been distilled into a list of seven recommendations (Section 5) for the asteroseismology community to study and absorb. In fact, while addressing activities (such as stellar classification or analysing and modelling light curves) that could be regarded as specific to the community in question, the recommendations include advice on matters such as improving communication, incorporating trans-disciplinary knowledge and involving the non-scientific public that are broad enough to serve as guidelines for the astrophysical community at large.

  2. The CoRoT satellite in flight: description and performance

    NASA Astrophysics Data System (ADS)

    Auvergne, M.; Bodin, P.; Boisnard, L.; Buey, J.-T.; Chaintreuil, S.; Epstein, G.; Jouret, M.; Lam-Trong, T.; Levacher, P.; Magnan, A.; Perez, R.; Plasson, P.; Plesseria, J.; Peter, G.; Steller, M.; Tiphène, D.; Baglin, A.; Agogué, P.; Appourchaux, T.; Barbet, D.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Boumier, P.; Bonneau, F.; Briet, R.; Butler, B.; Cautain, R.; Chiavassa, F.; Costes, V.; Cuvilho, J.; Cunha-Parro, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Docclo, A.; Drummond, R.; Dupuis, O.; Exil, G.; Fauré, C.; Gaboriaud, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gueguen, L.; Guivarc'h, V.; Guterman, P.; Hasiba, J.; Huntzinger, G.; Hustaix, H.; Imbert, C.; Jeanville, G.; Johlander, B.; Jorda, L.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafond, L.; Lapeyrere, V.; Landiech, P.; Larqué, T.; Laudet, P.; Le Merrer, J.; Leporati, L.; Leruyet, B.; Levieuge, B.; Llebaria, A.; Martin, L.; Mazy, E.; Mesnager, J.-M.; Michel, J.-P.; Moalic, J.-P.; Monjoin, W.; Naudet, D.; Neukirchner, S.; Nguyen-Kim, K.; Ollivier, M.; Orcesi, J.-L.; Ottacher, H.; Oulali, A.; Parisot, J.; Perruchot, S.; Piacentino, A.; Pinheiro da Silva, L.; Platzer, J.; Pontet, B.; Pradines, A.; Quentin, C.; Rohbeck, U.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Samadi, R.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Smit, H.; Sunter, W.; Tello, M.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Wallner, R.; Waultier, G.; Zanatta, P.

    2009-10-01

    Context: CoRoT is a space telescope dedicated to stellar seismology and the search for extrasolar planets. The mission is led by the CNES in association with French laboratories and has a large international participation. The European Space Agency (ESA), Austria, Belgium, and Germany contribute to the payload, and Spain and Brazil contribute to the ground segment. Development of the spacecraft, which is based on a PROTEUS low earth orbit (LEO) recurrent platform, commenced in October 2000, and the satellite was launched on December 27, 2006. Aims: The instrument and platform characteristics prior to launch have been described in ESA publication (SP-1306). In the present paper we explain the behaviour in flight, based on raw and corrected data. Methods: Five runs have been completed since January 2007. The data used here are essentially those acquired during the commissioning phase and from a long run that lasted 146 days. These enable us to give a complete overview of the instrument and platform behaviour for all environmental conditions. The ground based data processing is not described in detail because the most important method has been published elsewhere. Results: We show that the performance specifications are easily satisfied when the environmental conditions are favourable. Most of the perturbations, hence data corrections, are related to LEO perturbations: high energy particles inside the South Atlantic Anomaly (SAA), eclipses and temperature variations, and line of sight fluctuations due to the attitude control system. Straylight due to the reflected light from the earth, which is controlled by the telescope and baffle design, appears to be negligible. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with contributions from Austria, Belgium, Brazil, ESA, Germany and Spain. Four French laboratories associated with the CNRS (LESIA, LAM, IAS, OMP) collaborate with CNES on the satellite development. The

  3. RoHS regulated substances in mixed plastics from waste electrical and electronic equipment.

    PubMed

    Wäger, Patrick A; Schluep, Mathias; Müller, Esther; Gloor, Rolf

    2012-01-17

    The disposal and recovery of plastics from waste electrical and electronic equipment (WEEE) are of considerable importance, both from an environmental and an economic perspective. This paper presents the results of a study investigating current concentrations of hazardous substances in mixed plastics from WEEE and their implications for an environmentally sound recovery. The study included 53 sampling campaigns for mixed plastics from WEEE. The samples were analyzed with regard to heavy metals (cadmium, chromium, mercury, and lead) and flame retardants (PentaBDE, OctaBDE, DecaBDE, DecaBB) regulated in the RoHS Directive. Besides these substances, other brominated flame retardants known to occur in electronics (HBCD, TBBPA) as well as the total bromine and phosphorus contents were considered. Results show that no mixed plastics fraction from WEEE is completely free from substances regulated in the RoHS Directive. The lowest number and average concentrations were found in flat screen monitors. The highest concentrations were found in mixed plastics from CRT monitors and TVs. Mixed plastics fractions with high average concentrations of heavy metals originate from the treatment of small household appliances (cadmium), ICT equipment (lead), and consumer equipment (lead). Mixed plastics fractions with high average concentrations of brominated flame retardants mainly originate from the treatment of small household appliances for high temperature applications (DecaBDE), CRT monitors (OctaBDE and DecaBDE) and consumer equipment (DecaBDE), in particular CRT TVs (DecaBDE). To avoid a dissipation of hazardous substances into plastics and the environment, it is recommended that mixed plastics from WEEE are subject to a strict quality management.

  4. Presenting new exoplanet candidates for the CoRoT chromatic light curves

    NASA Astrophysics Data System (ADS)

    Boufleur, Rodrigo; Emilio, Marcelo; Andrade, Laerte; Janot-Pacheco, Eduardo; De La Reza, Ramiro

    2015-08-01

    One of the most promising topics of modern Astronomy is the discovery and characterization of extrasolar planets due to its importance for the comprehension of planetary formation and evolution. Missions like MOST (Microvariability and Oscillations of Stars Telescope) (Walker et al., 2003) and especially the satellites dedicated to the search for exoplanets CoRoT (Convection, Rotation and planetary Transits) (Baglin et al., 1998) and Kepler (Borucki et al., 2003) produced a great amount of data and together account for hundreds of new discoveries. An important source of error in the search for planets with light curves obtained from space observatories are the displacements occuring in the data due to external causes. This artificial charge generation phenomenon associated with the data is mainly caused by the impact of high energy particles onto the CCD (Pinheiro da Silva et al. 2008), although other sources of error, not as well known also need to be taken into account. So, an effective analysis of the light curves depends a lot on the mechanisms employed to deal with these phenomena. To perform our research, we developed and applied a different method to fix the light curves, the CDAM (Corot Detrend Algorithm Modified), inspired by the work of Mislis et al. (2012). The paradigms were obtained using the BLS method (Kovács et al., 2002). After a semiautomatic pre-analysis associated with a visual inspection of the planetary transits signatures, we obtained dozens of exoplanet candidates in very good agreement with the literature and also new unpublished cases. We present the study results and characterization of the new cases for the chromatic channel public light curves of the CoRoT satellite.

  5. A 60GHz RoF(radio-over-fiber) transmission system based on PM modulator

    NASA Astrophysics Data System (ADS)

    Wang, Xin; Liu, Yi; Wang, Wen-Ting

    2016-11-01

    As one of the most important applications of microwave photonic ROF (Radio over Fiber) system which combines the advantages of optical communication and wireless communication is a good candidate for broadband mobile Communication In this paper, we built and simulation a 60GHz RoF(Radio-over-Fiber) transmission system based on PM modulator. First, we introduce the PM-IM(Phase modulation to intensity modulation) modulation mechanisms by the breaking the phase balanced approach. This method solves the problem that the constant envelope (phase modulation signal) generated by the phase modulator can not be directly detected by a photo detector. A standard single-mode fiber (SMF) is connected input to the F-P(Fabry-Perot) optical filter, which is to achieve the PM-IM modulation conversion by changing the wavelength of the laser or the frequency of the modulation factor of the F-P optical filter to adapt to different fiber lengths and the signal transmission rate. These two methods which changing the phase relationship between the optical carrier and the optical side band can realize the ideal phase transition to obtain efficient and low loss modulation conversion. Finally, the simulation results show that different fiber lengths and the signal transmission rate configuration of different wavelength of the laser or the frequency of the modulation factor of the F-P optical filter, the BER performance and the eye diagram of the 60GHz RoF transmission system signals have been improved based on these PM-IM modulation methods.

  6. A self-consistent chemically stratified atmosphere model for the roAp star 10 Aquilae

    NASA Astrophysics Data System (ADS)

    Nesvacil, N.; Shulyak, D.; Ryabchikova, T. A.; Kochukhov, O.; Akberov, A.; Weiss, W.

    2013-04-01

    Context. Chemically peculiar A-type (Ap) stars are a subgroup of the CP2 stars that exhibit anomalous overabundances of numerous elements, e.g. Fe, Cr, Sr, and rare earth elements. The pulsating subgroup of Ap stars, the roAp stars, present ideal laboratories to observe and model pulsational signatures, as well as the interplay of the pulsations with strong magnetic fields and vertical abundance gradients. Aims: Based on high-resolution spectroscopic observations and observed stellar energy distributions, we construct a self-consistent model atmosphere for the roAp star 10 Aquilae (HD 176232). It accounts for modulations of the temperature-pressure structure caused by vertical abundance gradients. We demonstrate that such an analysis can be used to determine precisely the fundamental atmospheric parameters required for pulsation modelling. Methods: Average abundances were derived for 56 species. For Mg, Si, Ca, Cr, Fe, Co, Sr, Pr, and Nd, vertical stratification profiles were empirically derived using the DDAFit minimisation routine together with the magnetic spectrum synthesis codeSynthmag. Model atmospheres were computed with the LLmodels code, which accounts for the individual abundances and stratification of chemical elements. Results: For the final model atmosphere, Teff = 7550 K and log (g) = 3.8 were adopted. While Mg, Si, Co, and Cr exhibit steep abundance gradients, Ca, Fe, and Sr showed much wider abundance gradients between logτ5000 = -1.5 and 0.5. Elements Mg and Co were found to be the least stratified, while Ca and Sr showed strong depth variations in abundance of up to ≈ 6 dex. Table 4 and Figs. 10-12 are available in electronic form at http://www.aanda.org

  7. The CoRoT chemical peculiar target star HD 49310

    NASA Astrophysics Data System (ADS)

    Paunzen, E.; Fröhlich, H.-E.; Netopil, M.; Weiss, W. W.; Lüftinger, T.

    2015-02-01

    Context. The magnetic chemically peculiar (CP) stars of the upper main sequence are well-suited laboratories for investigating the influence of local magnetic fields on the stellar surface because they produce inhomogeneities (spots) that can be investigated in detail as the star rotates. Aims: We studied the inhomogeneous surface structure of the CP2 star HD 49310 based on high-quality CoRoT photometry obtained during 25 days. The data have nearly no gaps. This analysis is similar to a spectroscopic Doppler-imaging analysis, but it is not a tomographic method. Methods: We performed detailed light-curve fitting in terms of stationary circular bright spots. Furthermore, we derived astrophysical parameters with which we located HD 49310 within the Hertzsprung-Russell diagram. We also investigated the possible connection of this star to the nearby young open cluster NGC 2264. Results: With a Bayesian technique, we produced a surface map that shows six bright spots. After removing some artefacts, the residuals of the observed and synthetic photometric data are ± 0.123 mmag. The rotational period of the star is P = 1.91909 ± 0.00001 days. Our photometric observations therefore cover about 13 full rotational cycles. Three spots are very large with diameters of ≃ 40deg. The spots are brighter by 40% than the unperturbed stellar photosphere. Conclusions: HD 49310 is a classical silicon (CP2) star with a mass of about 3 M⊙. It is not a member of NGC 2264. Our analysis shows the potential of using high-quality photometric data to analyse the surface structure of CP stars. A comprehensive analysis of similar archival data, preferrably from space missions, would contribute significantly to our understanding of surface phenomena of CP stars and their temporal evolution. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  8. Microbial and Mineral Descriptions of the Interior Habitable Zones of Active Hydrothermal Chimneys from the Endeavour Segment, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Holden, J. F.; Lin, T.; Ver Eecke, H. C.; Breves, E.; Dyar, M. D.; Jamieson, J. W.; Hannington, M. D.; Butterfield, D. A.; Bishop, J. L.; Lane, M. D.

    2013-12-01

    Actively venting hydrothermal chimneys and their associated hydrothermal fluids were collected from the Endeavour Segment, Juan de Fuca Ridge to determine the mineralogy, chemistry and microbial community composition of their interiors. To characterize the mineralogy, Mössbauer, FTIR, VNIR and thermal emission spectroscopies were used for the first time on this type of sample in addition to thin-section petrography, x-ray diffraction and elemental analyses. A chimney from the Bastille edifice was Fe-sulfide rich and composed primarily of chalcopyrite, marcasite-sphalerite, and pyrrhotite while chimneys from the Dante and Hot Harold edifices were Fe-sulfide poor and composed primarily of anhydrite. The bulk emissivity and reflectance spectroscopies corroborated well with the petrography and XRD analyses. The microbial community in the interior of Bastille was most closely related to mesophilic-to-thermophilic anaerobes of the deltaproteobacteria and hyperthermophilic archaea while those in the interiors of Dante and Hot Harold were most closely related to mesophilic-to-thermophilic aerobes of the beta-, gamma- and epsilonproteobacteria. The fluid temperatures (282-321°C) and chemistries of the three chimneys were very similar suggesting that differences in mineralogy and microbial community compositions were more dependent on fluid flow characteristics and paragenesis within the chimney. Thin-section petrography of the interior of another hydrothermal chimney collected from the Dante edifice (emitting 336°C fluid) shows a thin coat of Fe3+ oxide associated with amorphous silica on the exposed outer surfaces of pyrrhotite, sphalerite and chalcopyrite in pore spaces, along with anhydrite precipitation in the pores that is indicative of seawater ingress. The Fe-sulfide minerals were likely oxidized to ferrihydrite with increasing pH and Eh due to cooling and seawater exposure, providing reactants for bioreduction. Culture-based most-probable-number estimates of

  9. Effects of a D2 receptor agonist RO 41-9067 alone and with clonidine on sleep parameters in the rat.

    PubMed

    Python, A; de Saint Hilaire, Z; Gaillard, J M

    1996-02-01

    The effects of RO 41-9067, a D2 dopamine receptors agonist, on different sleep parameters were studied in the rat. RO 41-9067 dose dependently decreased paradoxical sleep, and only at the higher dose increased waking during the light period. In contrast, the higher dose of RO 41-9067 increased paradoxical sleep and decreased waking during the dark period. Finally, the combination of RO 41-9067 and clonidine significantly prevent the decrease of total sleep time and paradoxical sleep found after clonidine alone. These results, compared with those of classical D2 dopamine receptors agonists, suggest an action for RO 41-9067 on D2 dopamine receptors depending on the cerebral structure, a different action particularly on the striatum and/or on the structures responsible for paradoxical sleep. An active role for D2 dopamine receptors and an interaction between noradrenergic and dopaminergic systems in the regulation of sleep is proposed.

  10. Temporal Spectral Analysis of Be stars observed with CoRoT satellite

    NASA Astrophysics Data System (ADS)

    Emilio, Marcelo; Janot Pacheco, Eduardo; Andrade, Laerte

    . Nevertheless, to measure frequencies with great accuracy in stars requires both high photometric precision and high time-frequency resolution. The CoRoT (Convection, Rotation and planetary Transits) satellite opens for the first time in history the possibility of fulfilling this goal. CoRoT is an experiment of astronomy dedicated to seismology and the detection of extrasolar planet transits. It was launched on December 2006 in an inertial polar orbit at an altitude of 897 mathrm{km}. The instrument is fed by a phi=27 textrm{cm} telescope. Its scientific program is three-fold consisting of: (1) The seismology core program (SISMO), which concerns the seismic study of ˜10 bright (6RoT ID 102761769 observed by CoRoT satellite. We found two close frequencies related to the .CoRoT ID 102761769 star. They are 2.465 c d(-1) (28.5 mathrm{mu Hz}) and 2.441 c d(-1) (28.2 mathrm{mu Hz}). The precision to which those frequencies were found is 0.018 c d(-1) (0.2 mathrm{mu Hz}). The projected stellar rotation was estimated to be 120 km s(-1) from the Fourier transform of spectral lines. If CoRoT-ID 102761769 is a typical Galactic Be star it rotates near the critical velocity. The critical rotation frequency of a typical B5-6 star is about 3.5 c d(-1) (40.5 mathrm{mu Hz}), which implies that the above frequencies are really caused by stellar pulsations rather than star's rotation. HD 171219 frequencies 1.113, 1.130, 1.146 c * d(-1) form a triplet with the

  11. Geochronology and geology of late Oligocene through Miocene volcanism and mineralization in the western San Juan Mountains, Colorado

    USGS Publications Warehouse

    Bove, Dana J.; Hon, Ken; Budding, Karin E.; Slack, John F.; Snee, Lawrence W.; Yeoman, Ross A.

    2001-01-01

    This paper presents 25 new 40Ar/39Ar dates from the main calc-alkaline ash-flow sheets and related younger plutons of the western San Juan volcanic field, the ash-flow sheets of the Lake City caldera cycle, and veins and other altered rocks in the Lake City region. The goal of the study was to produce similar quality 40Ar/39Ar ages to those currently published for the eastern and central San Juan Mountains. These new data provide a much more precise chronological framework for interpreting durations of events and their relationship to mineralization than do previously published conventional K-Ar dates for the western San Juan Mountains.

  12. Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306.

    PubMed

    Zhou, Xuefei; Liu, Xiangrui; Zhao, Bingxiang; Liu, Xin; Zhu, Dingcheng; Qiu, Nasha; Zhou, Quan; Piao, Ying; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing

    2016-07-28

    Successful transfection of plasmid DNA (pDNA) requires intranuclear internalization of pDNA effectively and the nuclear envelope appears to be one of the critical intracellular barriers for polymer mediated pDNA delivery. Polyethylenimine (PEI), as the classic cationic polymer, compact the negatively charged pDNA tightly and make up stable polyplexes. The polyplexes are too large to enter the nuclear through nuclear pores and it is believed that the nuclear envelope breakdown in mitosis could facilitate the nuclear entry of polyplexes. To jump the nuclear envelope barrier, we used a selective and reversible CDK1 inhibitor RO-3306 to control the G2/M transition of the cell cycle and increased the proportion of mitotic cells which have disappeared nuclear envelope during transfection. Herein, we show that RO-3306 remarkably increases the transfection efficiency of PEI polyplexes through enhanced nuclear localization of PEI and pDNA. However, RO-3306 is less effective to the charge-reversal polymer poly[(2-acryloyl)ethyl(p-boronic acid benzyl)diethylammonium bromide] (B-PDEAEA) which responses to cellular stimuli and releases free pDNA in cytoplasm. Our findings not only offer new opportunities for improving non-viral based gene delivery but also provide theoretical support for the rational design of novel functional polymers for gene delivery. We also report current data showing that RO-3306 synergizes TRAIL gene induced apoptosis in cancer cells.

  13. 77 FR 1707 - National Toxicology Program (NTP) Final Process for Preparation of the Report on Carcinogens (RoC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... available on the NTP Web site ( http://ntp.niehs.nih.gov/go/rocprocess ) or by contacting Dr. Ruth Lunn (see...) on December 15, 2011 ( http://ntp.niehs.nih.gov/go/9741 ). The NTP now announces the final process....gov/go/rocprocess ) or by contacting Dr. Lunn (see ADDRESSES). Background Information on the RoC...

  14. Behaviour of RO98pHt polyamide membrane in reverse osmosis and low reverse osmosis conditions for phenol removal.

    PubMed

    Hidalgo, A M; León, G; Gómez, M; Murcia, M D; Gómez, E; Gómez, J L

    2011-10-01

    Phenolic compounds and their derivatives are very common pollutants in wastewaters. Among the methods described for their removal, pressure-driven membrane processes are considered as a reliable alternative. Our research group has previously studied phenol removal in reverse osmosis (RO) conditions and obtained very low rejection percentages. Subsequently, when low reverse osmosis (LRO) conditions were studied, the organic rejection percentages improved. To further our knowledge in this respect, the main objective of this work was to study the behaviour of the polyamide thin-film composite membrane RO98pHt used for phenol removal in RO and LRO conditions. The influence of different operating pressures, phenol feed concentrations and pH on permeate flux and phenol rejection was studied. Low reverse osmosis conditions led to higher phenol rejection percentages in all the assayed conditions, suggesting that other factors related to the molecular characteristics of the organic molecules, such as solubility, acidity and hydrogen bonding capacity, play an important role in the rejection percentage attained. As expected, permeate flux was greater in RO conditions.

  15. The CoRoT-GES Collaboration: Improving red giants spectroscopic surface gravitity and abundances with asteroseismology

    NASA Astrophysics Data System (ADS)

    Valentini, M.; Chiappini, C.; Miglio, A.; Montalbán, J.; Rodrigues, T.; Mosser, B.; Anders, F.; the CoRoT RG Group; GES Consortium, the

    2016-09-01

    Nowadays large spectroscopic surveys, like the Gaia-ESO Survey (GES), provide unique stellar databases for better investigating the formation and evolution of our Galaxy. Great attention must be paid to the accuracy of the basic stellar properties derived: large uncertainties in stellar parameters lead to large uncertainties in abundances, distances and ages. Asteroseismology has a key role in this context: when seismic information is combined with information derived from spectroscopic analysis, highly precise constraints on distances, masses, extinction and ages of red giants can be obtained. In the light of this promising joint action, we started the CoRoT-GES collaboration. We present a set of 1111 CoRoT stars, observed by GES from December 2011 to July 2014, these stars belong to the CoRoT field LRc01, pointing at the inner Galactic disk. Among these stars, 534 have reliable global seismic parameters. By combining seismic informations and spectroscopy, we derived precise stellar parameters, ages, kinematic and orbital parameters and detailed element abundances for this sample of stars. We also show that, thanks to asteroseismology, we are able to obtain a higher precision than what can be achieved by the standard spectroscopic means. This sample of CoRoT red giants, spanning Galactocentric distances from 5 to 8 kpc and a wide age interval (1-13 Gyr), provides us a representative sample for the inner disk population.

  16. Measuring E(GSH) and H2O2 with roGFP2-based redox probes.

    PubMed

    Morgan, Bruce; Sobotta, Mirko C; Dick, Tobias P

    2011-12-01

    Redox biochemistry plays an important role in a wide range of cellular events. However, investigation of cellular redox processes is complicated by the large number of cellular redox couples, which are often not in equilibrium with one another and can vary significantly between subcellular compartments and cell types. Further, it is becoming increasingly clear that different redox systems convey different biological information; thus it makes little sense to talk of an overall "cellular redox state". To gain a more differentiated understanding of cellular redox biology, quantitative, redox couple-specific, in vivo measurements are necessary. Unfortunately our ability to investigate specific redox couples or redox-reactive molecules with the necessary degree of spatiotemporal resolution is very limited. The development of genetically encoded redox biosensors offers a promising new way to investigate redox biology. Recently developed redox-sensitive green fluorescent proteins (roGFPs), genetically fused to redox-active proteins, allow rapid equilibration of the roGFP moiety with a specific redox couple. Two probes based on this principle are now available: Grx1-roGFP2 for the measurement of glutathione redox potential (E(GSH)) and roGFP2-Orp1 for measuring changes in H(2)O(2) concentration. Here we provide a detailed protocol for the use of these probes in both yeast and mammalian systems using either plate-reader- or microscopy-based measurements.

  17. Downregulation of (3H)Ro5-4864 binding sites after exposure to peripheral-type benzodiazepines in vitro

    SciTech Connect

    Johnson, M.D.; Wang, J.K.; Morgan, J.I.; Spector, S.

    1986-09-01

    Peripheral-type benzodiazepine (BZD) binding sites undergo a rapid and pronounced downregulation after exposure to these compounds in vitro. Friend erythroleukemia cells were incubated with micromolar concentrations of BZD after which they were washed thoroughly and the binding of the specific peripheral-type BZD radioligand (/sup 3/H)Ro5-4864 was determined. Exposure to the peripheral-type BZD Ro7-3351 decreased the number of (/sup 3/H)Ro5-4864 binding sites from 324 to 41 fmol/10(6) cells with no change in affinity. Downregulation appears to require active cellular processes because it is blocked when exposure to BZD is at 4/sup 0/C rather than at 37/sup 0/C. Furthermore, whereas (/sup 3/H)Ro5-4864 binding is decreased substantially in membrane preparations made from downregulated cells, it is not altered when membrane preparations from control cells are exposed to BZD. The time course of downregulation is quite rapid, as it occurs within minutes. In contrast, the return of sites requires days and there is a close relationship between return of sites and growth of new cells. The ability of BZDs to downregulate correlates more closely with affinity for the peripheral-type site than with biological activity. The ability to undergo downregulation is characteristic of receptors and its occurrence suggests that peripheral-type BZD binding sites are functional receptors.

  18. Finest light curve details, physical parameters, and period fluctuations of CoRoT RR Lyrae stars

    NASA Astrophysics Data System (ADS)

    Benkő, J. M.; Szabó, R.; Derekas, A.; Sódor, Á.

    2016-12-01

    The CoRoT satellite supplied the scientific community with a huge data base of variable stars. Among them the RR Lyrae stars have intensively been discussed in numerous papers in the last few years, but the latest runs have not been checked to find RR Lyrae stars up to now. Our main goal was to fill this gap and complete the CoRoT RR Lyrae sample. We found nine unstudied RR Lyrae stars. Seven of them are new discoveries. We identified three new Blazhko stars. The Blazhko effect shows non-strictly repetitive nature for all stars. The frequency spectrum of the Blazhko star CoRoT 104948132 contains second overtone frequency with the highest known period ratio. The harmonic amplitude and phase declines with the harmonic order were studied for non-Blazhko stars. We found a period dependent but similar shape amplitude decline for all stars. We discovered significant random period fluctuation for one of the two oversampled target, CM Ori. After a successful transformation of the CoRoT band parameters to the Johnson V values we estimated the basic physical properties such as mass, luminosity, metallicity. The sample can be divided into two subgroups with respect to the metallicity but otherwise the physical parameters are in the canonical range of RR Lyrae stars.

  19. Beneficial phosphate recovery from reverse osmosis (RO) concentrate of an integrated membrane system using polymeric ligand exchanger (PLE).

    PubMed

    Kumar, Manish; Badruzzaman, Mohammad; Adham, Samer; Oppenheimer, Joan

    2007-05-01

    Phosphorus (P) discharge to surface water is a major environmental problem. Wastewater treatment is targeted towards removal of this nutrient to prevent degradation of surface water. Integrated membrane systems (IMS) are increasingly being considered for wastewater reclamation, and provide excellent removal of P compounds. However, reverse osmosis (RO), which forms an integral part of these IMSs, concentrates most dissolved substances including P-species such as phosphates in the RO waste stream. In this study, removal of phosphate from this stream using polymeric ligand exchange (PLE) resins was investigated. Further, the possibility of phosphate recovery through struvite (MgNH(4)PO(4).6H(2)O) precipitation was tested. Struvite has been promoted as a slow release fertilizer in recent years. This study demonstrates that PLEs can be successfully used to remove phosphate from RO-concentrate, and to recover more than 85% of the adsorbed phosphorus from the exhausted media and precipitated as a beneficial product (struvite). The approach, presented in this study, suggests advantages of providing economic benefit from a waste product (RO) while avoiding phosphorus discharge to the environment.

  20. Dengue Fever Trends and Climate Change in San Juan, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Muller-Karger, F. E.; Mendez-Lazaro, P.; Otis, D. B.; McCarthy, M.; Pena-Orellana, M.

    2014-12-01

    Climate change has important implications for public health. We developed and tested the hypothesis that conditions for dengue fever transmission in San Juan (Puerto Rico, USA) are becoming favorable as a result of meteorological drivers being modified with climate change. Sea level pressure, mean sea level (MSL), wind, sea surface temperature (SST), air surface temperature (AST), rainfall, and confirmed dengue cases were variables examined over the past 30 years, or longer for some variables. Statistical tools used included Principal Component Analysis, Pearson correlation coefficient, Mann-Kendall trend tests, and logistic regressions. Results show that dry days are increasing and that wet days are decreasing. MSL is steadily increasing, which increases the risk of dengue cases along the coast, as the perimeter of the San Juan Bay estuary expands and the shoreline moves inland. Warming is evident in both SST and AST. Maximum and minimum air surface temperature extremes have also increased. Incidence of dengue is accelerating along with environmental change. For example, between 2000-2011, dengue transmission increased by a factor of 3.4 (95% CI: 1.9-6.1) for each 1ºC increase in SST. Between 2007 and 2011, this risk factor increased to 5.2 (95% CI: 1.9-13.9) for every 1ºC increase in SST. An important but difficult to examine problem is how social and economic factors affect such dengue fever transmission rates in light of environmental change. A concern is that the patterns observed in San Juan are representative of potential incidence of dengue virus in other parts of the island of Puerto Rico and in other Caribbean nations. These results help understand patterns of disease spreading, and allow public health officials to evaluate scenarios and interventions intended to mitigate the impacts of climate change.

  1. A heat vulnerability index to improve urban public health management in San Juan, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E.; Otis, Daniel; McCarthy, Matthew J.; Rodríguez, Ernesto

    2017-02-01

    Increased frequency and length of high heat episodes are leading to more cardiovascular issues and asthmatic responses among the population of San Juan, the capital of the island of Puerto Rico, USA. An urban heat island effect, which leads to foci of higher temperatures in some urban areas, can raise heat-related mortality. The objective of this research is to map the risk of high temperature in particular locations by creating heat maps of the city of San Juan. The heat vulnerability index (HVI) maps were developed using images collected by satellite-based remote sensing combined with census data. Land surface temperature was assessed using images from the Thermal Infrared Sensor flown on Landsat 8. Social determinants (e.g., age, unemployment, education and social isolation, and health insurance coverage) were analyzed by census tract. The data were examined in the context of land cover maps generated using products from the Puerto Rico Terrestrial Gap Analysis Project (USDA Forest Service). All variables were set in order to transform the indicators expressed in different units into indices between 0 and 1, and the HVI was calculated as sum of score. The tract with highest index was considered to be the most vulnerable and the lowest to be the least vulnerable. Five vulnerability classes were mapped (very high, high, moderate, low, and very low). The hottest and the most vulnerable tracts corresponded to highly built areas, including the Luis Munoz International Airport, seaports, parking lots, and high-density residential areas. Several variables contributed to increased vulnerability, including higher rates of the population living alone, disabilities, advanced age, and lack of health insurance coverage. Coolest areas corresponded to vegetated landscapes and urban water bodies. The urban HVI map will be useful to health officers, emergency preparedness personnel, the National Weather Service, and San Juan residents, as it helps to prepare for and to mitigate

  2. A heat vulnerability index to improve urban public health management in San Juan, Puerto Rico.

    PubMed

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E; Otis, Daniel; McCarthy, Matthew J; Rodríguez, Ernesto

    2017-02-17

    Increased frequency and length of high heat episodes are leading to more cardiovascular issues and asthmatic responses among the population of San Juan, the capital of the island of Puerto Rico, USA. An urban heat island effect, which leads to foci of higher temperatures in some urban areas, can raise heat-related mortality. The objective of this research is to map the risk of high temperature in particular locations by creating heat maps of the city of San Juan. The heat vulnerability index (HVI) maps were developed using images collected by satellite-based remote sensing combined with census data. Land surface temperature was assessed using images from the Thermal Infrared Sensor flown on Landsat 8. Social determinants (e.g., age, unemployment, education and social isolation, and health insurance coverage) were analyzed by census tract. The data were examined in the context of land cover maps generated using products from the Puerto Rico Terrestrial Gap Analysis Project (USDA Forest Service). All variables were set in order to transform the indicators expressed in different units into indices between 0 and 1, and the HVI was calculated as sum of score. The tract with highest index was considered to be the most vulnerable and the lowest to be the least vulnerable. Five vulnerability classes were mapped (very high, high, moderate, low, and very low). The hottest and the most vulnerable tracts corresponded to highly built areas, including the Luis Munoz International Airport, seaports, parking lots, and high-density residential areas. Several variables contributed to increased vulnerability, including higher rates of the population living alone, disabilities, advanced age, and lack of health insurance coverage. Coolest areas corresponded to vegetated landscapes and urban water bodies. The urban HVI map will be useful to health officers, emergency preparedness personnel, the National Weather Service, and San Juan residents, as it helps to prepare for and to mitigate

  3. Marine Biodiversity in Juan Fernández and Desventuradas Islands, Chile: Global Endemism Hotspots

    PubMed Central

    Friedlander, Alan M.; Ballesteros, Enric; Caselle, Jennifer E.; Gaymer, Carlos F.; Palma, Alvaro T.; Petit, Ignacio; Varas, Eduardo; Muñoz Wilson, Alex; Sala, Enric

    2016-01-01

    The Juan Fernández and Desventuradas islands are among the few oceanic islands belonging to Chile. They possess a unique mix of tropical, subtropical, and temperate marine species, and although close to continental South America, elements of the biota have greater affinities with the central and south Pacific owing to the Humboldt Current, which creates a strong biogeographic barrier between these islands and the continent. The Juan Fernández Archipelago has ~700 people, with the major industry being the fishery for the endemic lobster, Jasus frontalis. The Desventuradas Islands are uninhabited except for a small Chilean military garrison on San Félix Island. We compared the marine biodiversity of these islands across multiple taxonomic groups. At San Ambrosio Island (SA), in Desventuradas, the laminarian kelp (Eisenia cokeri), which is limited to Desventuradas in Chile, accounted for >50% of the benthic cover at wave exposed areas, while more sheltered sites were dominated by sea urchin barrens. The benthos at Robinson Crusoe Island (RC), in the Juan Fernández Archipelago, comprised a diverse mix of macroalgae and invertebrates, a number of which are endemic to the region. The biomass of commercially targeted fishes was >2 times higher in remote sites around RC compared to sheltered locations closest to port, and overall biomass was 35% higher around SA compared to RC, likely reflecting fishing effects around RC. The number of endemic fish species was extremely high at both islands, with 87.5% of the species surveyed at RC and 72% at SA consisting of regional endemics. Remarkably, endemics accounted for 99% of the numerical abundance of fishes surveyed at RC and 96% at SA, which is the highest assemblage-level endemism known for any individual marine ecosystem on earth. Our results highlight the uniqueness and global significance of these biodiversity hotspots exposed to very different fishing pressures. PMID:26734732

  4. Quantification of Methane and Ethane Emissions from the San Juan Basin

    NASA Astrophysics Data System (ADS)

    Smith, M. L.; Kort, E. A.; Karion, A.; Sweeney, C.; Gvakharia, A.

    2015-12-01

    Methane (CH4), a potent greenhouse gas, and the primary component of natural gas, is emitted from areas of high fossil fuel production and processing. Recently, persistent and large methane emissions (~0.59 Tg yr-1) from the four corners area of the United States have been identified using satellite (SCIAMACHY) observations taken over the years 2003 to 2009. These emissions appear to be the largest CH4 anomaly (positive deviation above background values) in the contiguous U.S., and exceed bottom-up inventory estimates for the area by 1.8 to 3.5 times. The majority of emissions sources expected to contribute to this anomalous CH4 signal are located in the San Juan basin of New Mexico, and include harvesting and processing of natural gas, coal, and coalbed CH4. The magnitude of CH4 emissions from the San Juan basin have not yet been directly quantified using airborne measurements. Additionally, changing fossil fuel-related activities in the basin may have altered the magnitude of CH4 emissions compared to estimates derived from 2003-2009 satellite measurements. Here, we present in-situ airborne observations of CH4 over the San Juan basin, which allow tight quantification of CH4 fluxes using the mass balance method. Observations over the basin were taken for multiple wind directions on multiple days in April, 2015 to obtain a robust estimate of CH4 emissions. The flux of ethane (C2H6), the second most abundant component of natural gas and a tracer species indicative of fossil-derived CH4, was also quantified. Substantial C2H6 emissions may affect regional air quality and chemistry through its influence on tropospheric ozone production.

  5. Regional acoustic imagery and detailed geophysical studies of northern Juan de Fuca Ridge

    SciTech Connect

    Davis, E.E.; Currie, R.G.; Villinger, H.; Goodfellow, W.D.; Hussong, D.M.; Ryan, W.B.F.; Hammond, S.R.

    1986-07-01

    Acoustic image and high-resolution swath mapping studies have been conducted over the northern Juan de Fuca Ridge system from the central Juan de Fuca Ridge at lat. 46/sup 0/N to the triple junction of the ridge with the Queen Charlotte Islands continental margin at lat. 52/sup 0/N. Results of the surveys have been published as 1:250,000 compilations and 1:50,000 detailed sheets of acoustic image mosaics and 10-m contour bathymetric maps. Of particular interest is the information that influences processes of hydrothermal mineralization. In general, little direct information is present in the imagery; only the exact location and nature of the currently active rift axis are seen. However, this information is important, since the along-strike variations in crestal morphology, the recency and level of volcanic activity, and the degree of post-volcanic extension must be known in order to understand any hydrothermal system observed along the axis. An exceptional case has been studied in detail at the northern Juan de Fuca Ridge, lat. 49/sup 0/30'N, where Pleistocene turbidite sediments bury the axial valley, and structures suspected to be of hydrothermal origin were observed in the acoustic imagery over faults that bound the valley. Subsequent higher resolution acoustic imagery, seismic reflection profiling, and heat-flow studies indicated that the features were of hydrothermal origin. A 2.5-m piston core sample of massive sulfides from one of the structures confirmed this speculation. The setting in which these relatively large (500-m diameter, 60-m surficial relief, 350-m relief above basement) structures occur is remarkably similar to that where large sediment-hosted sulfide deposits are found on land, although they do not know what the bulk composition of the structures is, and thus whether the analogy is complete.

  6. Applications of geographic information systems (GIS) to exploration studies in the San Juan basin, New Mexico

    SciTech Connect

    Miller, B.M. )

    1990-05-01

    The US Geological Survey (USGS) is currently applying geographic information systems (GIS) technology to develop a geologic knowledge base that will provide the framework for an integrated basin analysis for the San Juan basin. GIS technology involves the integration of mapping and data-base functions that enable the user to integrate and manipulate spatial (coordinate) data with attribute (thematic) data in order to combine complex geographic, geologic, and geophysical data sets into resultant overlay and composite maps and to conduct multivariate exploratory data analysis and have access to a variety of options for analyzing these databases. The San Juan basin, a 13,500-mi{sup 2} Laramide structural basin in northwestern New Mexico, was chosen for the pilot project. The basin encompasses a maximum of over 15,000 ft of Paleozoic to Eocene sedimentary rock and contains economic deposits of natural gas, oil, coal, and uranium. Successful exploration in this basin requires an understanding of the complex stratigraphy and structural geology controlling the distribution of these resources. GIS technology applied to the San Juan basin includes both surface and subsurface data sets that establish a three-dimensional perspective of the basin's fundamental stratigraphic and structural framework and aid in the identification of its temporal and tectonic relationships relative to origin and occurrence of its resources. Among the digital data bases used for surface mapping is the US GeoData system from the USGS's national mapping program, which includes digital elevation models (DEM) for terrain elevations: digital line graphs (DLG) for planimetric information on boundaries, transportation, hydrography, and the US Public Land Survey system; and land use and land cover (LULC) data. Additional data bases used for surface mapping include surficial geology, locations of oil and gas wells, well status, and oil and gas fields.

  7. Hydrothermal venting on the Juan de Fuca Ridge over the last 600,000 years

    NASA Astrophysics Data System (ADS)

    Costa, K.; McManus, J. F.; Winckler, G.; Huybers, P. J.; Langmuir, C. H.; Giosan, L.; Middleton, J. L.; Mukhopadhyay, S.

    2015-12-01

    Mid-ocean ridges provide a unique chemical, physical, and biological environment on the seafloor. They are a significant source of dissolved Fe, a critical micronutrient in the ocean, and they are a primary source of CO2 from the mantle, Earth's largest carbon reservoir. Although more than a hundred modern hydrothermal systems have been discovered, few records of their variation through geological time have been obtained. Sediments near ocean ridges hold the potential to provide such records, and here we investigate sediments near the Juan de Fuca Ridge through continuous XRF scans coupled with oxygen isotope temporal constraints to explore hydrothermal activity over the past 600,000 years. These are the first records over multiple glacial-interglacial cycles and permit investigation of potential feedbacks between glacial-interglacial climate change and hydrothermal activity. Today, hydrothermal activity on the Juan de Fuca Ridge is characterized by hydrothermal particles with high concentrations of Fe, Cu, and Zn (Feely et. al., 1987). Over longer time scales, Fe concentrations are positively correlated with Ti (r2≥0.75), so that the dominant variability in Fe is due to the input of lithogenic material. Additional Fe inputs from hydrothermal activity increase the Fe/Ti ratio above the lithogenic value of 11.7 wt%/wt%. Intense hydrothermal activity (Fe/Ti > 25 wt%/wt%) is observed on the Juan de Fuca Ridge from ~375-430ka, and less intense but still elevated hydrothermal activity (Fe/Ti > 17 wt%/wt%) recurs at near 100kyr cyclicity, from 80-120ka, 180-220ka, 290-330ka, and 470-520ka. These time periods correspond to times of sea level fall owing to expanding ice volume, supporting a link between sea level changes and ridge crest activity

  8. Marine Biodiversity in Juan Fernández and Desventuradas Islands, Chile: Global Endemism Hotspots.

    PubMed

    Friedlander, Alan M; Ballesteros, Enric; Caselle, Jennifer E; Gaymer, Carlos F; Palma, Alvaro T; Petit, Ignacio; Varas, Eduardo; Muñoz Wilson, Alex; Sala, Enric

    2016-01-01

    The Juan Fernández and Desventuradas islands are among the few oceanic islands belonging to Chile. They possess a unique mix of tropical, subtropical, and temperate marine species, and although close to continental South America, elements of the biota have greater affinities with the central and south Pacific owing to the Humboldt Current, which creates a strong biogeographic barrier between these islands and the continent. The Juan Fernández Archipelago has ~700 people, with the major industry being the fishery for the endemic lobster, Jasus frontalis. The Desventuradas Islands are uninhabited except for a small Chilean military garrison on San Félix Island. We compared the marine biodiversity of these islands across multiple taxonomic groups. At San Ambrosio Island (SA), in Desventuradas, the laminarian kelp (Eisenia cokeri), which is limited to Desventuradas in Chile, accounted for >50% of the benthic cover at wave exposed areas, while more sheltered sites were dominated by sea urchin barrens. The benthos at Robinson Crusoe Island (RC), in the Juan Fernández Archipelago, comprised a diverse mix of macroalgae and invertebrates, a number of which are endemic to the region. The biomass of commercially targeted fishes was >2 times higher in remote sites around RC compared to sheltered locations closest to port, and overall biomass was 35% higher around SA compared to RC, likely reflecting fishing effects around RC. The number of endemic fish species was extremely high at both islands, with 87.5% of the species surveyed at RC and 72% at SA consisting of regional endemics. Remarkably, endemics accounted for 99% of the numerical abundance of fishes surveyed at RC and 96% at SA, which is the highest assemblage-level endemism known for any individual marine ecosystem on earth. Our results highlight the uniqueness and global significance of these biodiversity hotspots exposed to very different fishing pressures.

  9. Impacts of Urbanization in the Coastal Tropical City of San Juan, Puerto Rico

    NASA Technical Reports Server (NTRS)

    Comarazamy, Daniel E.; Gonzalez, Jorge E.; Luvall, Jeffrey C.; Rickman, Douglas L.; Mulero, Pedro J.

    2007-01-01

    Urban sprawl in tropical locations is rapidly accelerating and it is more evident in islands where a large percentage of the population resides along the coasts. This paper focuses on the analysis of the impacts of land use and land cover for urbanization in the tropical coastal city of San Juan, in the Caribbean island of Puerto Rico. A mesoscale numerical model, the Regional Atmospheric Modeling System (RAMS), is used to study the impacts of land use for urbanization in the environment including specific characteristics of the urban heat island in the San Juan Metropolitan Area (SJMA), one of the most noticeable urban cores of the Caribbean. The research also makes use of the observations obtained during the airborne San Juan Atlas Mission. Surface and rawinsonde data from the mission are used to validate the atmospheric model yielding satisfactory results. Airborne high resolution remote sensing data are used to update the model's surface characteristics in order to obtain a more accurate and detailed configuration of the SJMA and perform a climate impact analysis based on land cover/land use (LCLU) changes. The impact analysis showed that the presence of the urban landscape of San Juan has an impact reflected in higher air temperatures over the area occupied by the city, with positive values of up to 2.5 C, for the simulations that have specified urban LCLU indexes in the model's bottom boundary. One interesting result of the impact analysis was the finding of a precipitation disturbance shown as a difference in total accumulated rainfall between the present urban landscape and with a potential natural vegetation, apparently induced by the presence of the urban area. Results indicate that the urban enhanced cloud formation and precipitation development occur mainly downwind of the city, including the accumulated precipitation. This spatial pattern can be explained by the presence of a larger urbanized area in the southwest sector of the city, and of the

  10. Effects of Hydrostatic Pressure on Growth of Hyperthermophilic Archaebacteria from the Juan de Fuca Ridge †

    PubMed Central

    Reysenbach, Anna-Louise; Deming, Jody W.

    1991-01-01

    Two new strains (AL1 and AL2) of hyperthermophilic, sulfur-reducing, heterotrophic archaebacteria from high-temperature (350°C) vents on the Juan de Fuca Ridge were highly barotolerant at their optimal growth temperatures (90 and 100°C, respectively). A trend towards barophily at pressures greater than those encountered in situ at the sea floor was demonstrated for the more extremely thermophilic strain (AL2), implying an ability to thrive in (unexplored) habitats well below accessible vent formations. PMID:16348469

  11. Geochemical variability of natural soils and reclaimed minespoil soils in the San Juan Basin, New Mexico

    USGS Publications Warehouse

    Gough, L.P.; Severson, R.C.

    1981-01-01

    An inventory of total-and extractable-element concentrations in soils was made for three areas of the San Juan Basin in New Mexico: (1) the broad area likely to be affected by energy-related development. (2) an area of soils considered to have potential for use as topsoil in mined-land reclamation. and (3) an area of the San Juan coal mine that has been regraded. topsoiled, and revegetated. Maps made of concentrations of 16 elements in area 1 soils show no gradational pattern across the region. Further. these maps do not correspond to those showing geology or soil types. Sodic or saline problems, and a possible but unproven deficiency of zinc available to plants. may make some of the soils in this area undesirable for use as topsoil in mined-land reclamation. Taxonomic great groups of soil in this area cannot be distinguished because each great group tends to have a large within-group variability if compared to the between-group variability. In area 2 the major soils sampled were of the Sheppard. Shiprock. and Doak association. These soils are quite uniform in chemical composition and are not greatly saline or sodic. As in area 1 soils. zinc deficiency may cause a problem in revegetating most of these soils. It is difficult to distinguish soil taxonomic families by using their respective chemical compositions. because of small between-family variability. Topsoil from a reclaimed area of the San Juan mine (area 3) most closely resembles the chemical composition of natural C horizons of soil from area 1. Spoil material that has not been topsoiled is likely to cause sodic-and saline-related problems in revegetation and may cause boron toxicity in plants. Topsoiling has apparently ameliorated these potential problems for plant growth on mine spoil. Total and extractable concentrations for elements and other parameters for each area of the San Juan Basin provide background information for the evaluation of the chemical quality of soils in each area.

  12. [Study of prevalence of pain at the Juan Canalejo Hospital in La Coruña].

    PubMed

    Valero, J; Palacios, P; Vazquez-Barro, A; Lopez-Suso, E; Carpintero, D

    1995-12-01

    A study of prevalence of pain conducted in 812 patients admitted in the Juan Canalejo Hospital in La Coruña (Spain). This is primarily an adult hospital. Of the 650 patients whose replies were deemed valid, 35.69% were suffering pain. Other findings were that the sociocultural level of the patients affected their assessment of pain and that 46.12% of those who were suffering pain were not receiving analgesics at that time. Magnesium dipyrone, a combination of paracetamol and codeine and morphine were the most commonly used drugs, although there was clearunderuse of analgesic.

  13. [Urban demography and marriage age in nineteenth-century Puerto Rico: the case of San Juan].

    PubMed

    Matos Rodriguez, F V

    1998-01-01

    "This paper analyses the age at first marriage among the racial groups in San Juan, the capital of Puerto Rico, during the first half of [the] XIX century, using censuses of population.... We also give a short panorama of the demographic transformations experienced by the city during the same period. Over all we explain the change from a context where women and [non whites] were the majority until a new context [in the]1850 decade, where the majority was composed [of] men and [whites]." (EXCERPT)

  14. [Dr. Juan Ramon Beltran and his contribution to the School of Dentistry].

    PubMed

    Zarranz, A

    1999-01-01

    He was in charge of the course of Legal Dentistry at the School of Dentistry from 1929 through 1932. He prepared the study program for this subject, basing it on the experience he had gained as professor in Legal Medicine at the Faculty of Medical Sciences in Buenos Aires. He published the book "Medicina Legal para la ensenanza de la Odontologia Legal y Social" (1932), and its second edition included an important contribution made by Dr. Juan Ubaldo Carrea, Main Professor of Orthodontics with Legal Dentistry at this school

  15. San Juan single-well seismic data analysis and modeling study

    SciTech Connect

    Daley, Tom; Wu, C.; Harris, J.M.; Daley, T.M.; Majer, E.L.

    2004-02-26

    The authors analyze single-well seismic data from the San Juan basin in Northwest New Mexico. The consistently observable events are tube-waves: direct, reflected and multiple tube-waves can be explained by the formation properties and survey geometry except for an anomalous zone with low velocity, high amplitude and horizontal polarization. To aid the data analysis, forward modeling using a variable-grid finite-difference parallel code is performed. The numerical result confirms the identified events in the field observations.

  16. The fate of the Juan de Fuca plate: Implications for a Yellowstone plume head

    NASA Astrophysics Data System (ADS)

    Xue, Mei; Allen, Richard M.

    2007-12-01

    Beneath the Pacific Northwest the Juan de Fuca plate, a remnant of the Farallon plate, continues subducting beneath the North American continent. To the east of the Cascadia subduction zone lies the Yellowstone Hotspot Track. The origins of this track can be traced back to the voluminous basaltic outpourings in the Columbia Plateau around 17 Ma. If these basalts are the result of a large melting anomaly rising through the mantle to the base of the North American continent, such as a mantle plume head, the anomaly would need to punch through the subducting Juan de Fuca slab. Here, we use teleseismic body-wave travel-time tomography to investigate the fate of the subducted slab and its possible interaction with a plume head. Our dataset is derived from the Oregon Array for Teleseismic Study (OATS) deployment in Oregon and all other available seismic data in this region during the same period. In our JdF07 models, we image the subducted Juan de Fuca plate in the mantle east of the Cascades beneath Oregon, where the slab has not been imaged before, to a depth of 400 km but no deeper. The slab dips ˜ 50°E and has a thickness of ˜ 75 km. Immediately beneath the slab, we image a low velocity layer with a similar geometry to the slab and extending down to at least ˜ 575 km depth in the V s model. The total length of the high velocity slab is ˜ 660 km, about 180 km longer than the estimated length of slab subducted since 17 Ma. Assuming similar slab geometry to today, this 180 km length of slab would reach ˜ 60 km depth, comparable to the thickness of continental lithosphere. We propose that the absence of the slab below 400 km today is due to the arrival of the Yellowstone plume head ˜ 17 Ma, which destroyed the Juan de Fuca slab at depths greater than the thickness of the continental lithosphere. Given this scenario, the low velocity anomaly beneath the slab is likely the remnant plume head material which has been pulled down by traction with the subducting plate

  17. Isotopic evidence of Holocene climatic change in the San Juan Mountains, Colorado

    USGS Publications Warehouse

    Friedman, I.; Carrara, P.; Gleason, J.

    1988-01-01

    The ??D of cellulose from 14C-dated wood, collected in the San Juan Mountains of southwestern Colorado, decreased by about 45??? from 9600 to 3100 yr B.P. and an additional 25??? to the present. The wood samples are from trees that grew above present-day tree line and reflect a time of warmer average summer temperatures. These changes in ??D are interpreted to indicate a major change during the Holocene in the sources of moisture, in the seasonality of precipitation, or in both. ?? 1988.

  18. The expression of RoTat 1.2 variable surface glycoprotein (VSG) in Trypanosoma evansi and T. equiperdum.

    PubMed

    Claes, F; Verloo, D; De Waal, D T; Majiwa, P A O; Baltz, T; Goddeeris, B M; Büscher, P

    2003-10-20

    In order to define whether the variable antigenic type RoTat 1.2 is restricted to Trypansoma evansi and could be used as antigen in serological tests to differentiate T. evansi from Trypansoma equiperdum, the appearance of RoTat 1.2-specific antibodies in rabbits, experimentally infected with T. evansi and T. equiperdum, respectively, was analyzed. Ten strains of T. evansi and 11 strains of T. equiperdum originating from Asia, Europe, Africa and Latin America were tested. Rabbit pre-infection sera and sera of days 7, 14, 25, 35 post-infection (p.i.) were analyzed for the presence of antibodies reactive with RoTat 1.2 in immune trypanolysis, ELISA/T. evansi and CATT/T. evansi. Within the duration of the infection (maximum 35 days), all T. evansi as well as 9 out of 11 T. equiperdum infected rabbits became positive in all these tests. The rabbits infected with T. equiperdum OVI (South Africa) and BoTat 1.1 (Morocco) remained negative in the immune trypanolysis test although the latter rabbit became positive in the CATT/T. evansi and ELISA/T. evansi. On the contrary, both rabbits were positive in immune trypanolysis when tested against their respective infecting population. From these data, we conclude that most T. equiperdum strains express isoVATs of RoTat 1.2. This explains, in part, why antibody tests based on T. evansi RoTat 1.2 cannot reliably distinguish between infections caused by T. evansi and those caused by T. equiperdum unless it can be proven that most described T. equiperdum are actually misclassified T. evansi.

  19. Water reuse: >90% water yield in MBR/RO through concentrate recycling and CO2 addition as scaling control.

    PubMed

    Joss, Adriano; Baenninger, Claudia; Foa, Paolo; Koepke, Stephan; Krauss, Martin; McArdell, Christa S; Rottermann, Karin; Wei, Yuansong; Zapata, Ana; Siegrist, Hansruedi

    2011-11-15

    Over 1.5 years continuous piloting of a municipal wastewater plant upgraded with a double membrane system (ca. 0.6 m(3) d(-1) of product water produced) have demonstrated the feasibility of achieving high water quality with a water yield of 90% by combining a membrane bioreactor (MBR) with a submerged ultrafiltration membrane followed by a reverse osmosis membrane (RO). The novelty of the proposed treatment scheme consists of the appropriate conditioning of MBR effluent prior to the RO and in recycling the RO concentrates back to the biological unit. All the 15 pharmaceuticals measured in the influent municipal sewage were retained below 100 ng L(-1), a proposed quality parameter, and mostly below detection limits of 10 ng L(-1). The mass balance of the micropollutants shows that these are either degraded or discharged with the excess concentrate, while only minor quantities were found in the excess sludge. The micropollutant load in the concentrate can be significantly reduced by ozonation. A low treated water salinity (<10 mM inorganic salts; 280 ± 70 μS cm(-1)) also confirms that the resulting product has a high water quality. Solids precipitation and inorganic scaling are effectively mitigated by lowering the pH in the RO feed water with CO(2) conditioning, while the concentrate from the RO is recycled to the biological unit where CO(2) is stripped by aeration. This causes precipitation to occur in the bioreactor bulk, where it is much less of a process issue. SiO(2) is the sole exception. Equilibrium modeling of precipitation reactions confirms the effectiveness of this scaling-mitigation approach for CaCO(3) precipitation, calcium phosphate and sulfate minerals.

  20. Low-amplitude variations detected by CoRoT in the B8IIIe star HD 175869

    NASA Astrophysics Data System (ADS)

    Gutiérrez-Soto, J.; Floquet, M.; Samadi, R.; Neiner, C.; Garrido, R.; Fabregat, J.; Frémat, Y.; Diago, P. D.; Huat, A.-L.; Leroy, B.; Emilio, M.; Hubert, A.-M.; Andrade, O. Thizy L.; de Batz, B.; Janot-Pacheco, E.; Espinosa Lara, F.; Martayan, C.; Semaan, T.; Suso, J.; Auvergne, M.; Chaintreuil, S.; Michel, E.; Catala, C.

    2009-10-01

    Context: The origin of the short-term variability in Be stars remains a matter of controversy. Pulsations and rotational modulation are the components of the favored hypothesis. Aims: We present our analysis of CoRoT data of the B8IIIe star HD 175869 observed during the first short run in the center direction (SRC1). Methods: We review both the instrumental effects visible in the CoRoT light curve and the analysis methods used by the CoRoT Be team. We applied these methods to the CoRoT light curve of the star HD 175869. A search for line-profile variations in the spectroscopic data was also performed. We also searched for a magnetic field, by applying the LSD technique to spectropolarimetric data. Results: The light curve exhibits low-amplitude variations of the order of 300 μmag with a double wave shape. A frequency within the range determined for the rotational frequency and 6 of its harmonics are detected. The main frequency and its first harmonic exhibit amplitude variations of a few days. Other significant frequencies of low-amplitude from 25 to a few μmag are also found. The analysis of line profiles from ground-based spectroscopic data does not detect any variation. In addition, no Zeeman signature was found. Conclusions: Inhomogeneities caused by stellar activity in or just above the photosphere are proposed to produce the photometric variability detected by CoRoT in the Be star HD 175869. The hypothesis that non-radial pulsations are the origin of these variations cannot be excluded.

  1. Comparative clustering analysis of variable stars in the Hipparcos, OGLE Large Magellanic Cloud, and CoRoT exoplanet databases

    NASA Astrophysics Data System (ADS)

    Sarro, L. M.; Debosscher, J.; Aerts, C.; López, M.

    2009-10-01

    Context: Discovery of new variability classes in large surveys using multivariate statistics techniques such as clustering, relies heavily on the correct understanding of the distribution of known classes as point processes in parameter space. Aims: Our objective is to analyze the correspondence between the classical stellar variability types and the clusters found in the distribution of light curve parameters and colour indices of stars in the CoRoT exoplanet sample. The final aim is to help in the identification on new types of variability by first identifying the well known variables in the CoRoT sample. Methods: We apply unsupervised classification algorithms to identify clusters of variable stars from modes of the probability density distribution. We use reference variability databases (Hipparcos and OGLE) as a framework to calibrate the clustering methodology. Furthermore, we use the results from supervised classification methods to interpret the resulting clusters. Results: We interpret the clusters in the Hipparcos and OGLE LMC databases in terms of large-amplitude radial pulsators in the classical instability strip and of various types of eclipsing binaries. The Hipparcos data also provide clear distributions for low-amplitude nonradial pulsators. We show that the preselection of targets for the CoRoT exoplanet programme results in a completely different probability density landscape than the OGLE data, the interpretation of which involves mainly classes of low-amplitude variability in main-sequence stars. Our findings will be incorporated to improve the supervised classification used in the CoRoT catalogue production, once the existence of new classes or subtypes will be confirmed from complementary spectroscopic observations. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  2. SEISMICITY AND VOLCANISM IN THE PACIFIC NORTHWEST: EVIDENCE FOR THE SEGMENTATION OF THE JUAN DE FUCA PLATE.

    USGS Publications Warehouse

    Weaver, Craig S.; Michaelson, Caryl A.

    1985-01-01

    The distributions of earthquakes and late Cenozoic and Quaternary volcanism in Washington and northern Oregon change markedly across two northeast-striking lines, one near Mount Rainier and one near Mount Hood. On the basis of these observations and a comparison with the Nazoa subduction zone, we propose that the Juan de Fuca subduction zone is divided into two segments. Landward of the coastal thrust zone, we suggest the Juan de Fuca plate dips more steeply beneath the southern segment than beneath the northern segment. Refs.

  3. Geology, thermal maturation, and source rock geochemistry in a volcanic covered basin: San Juan sag, south-central Colorado

    USGS Publications Warehouse

    Gries, R.R.; Clayton, J.L.; Leonard, C.

    1997-01-01

    The San Juan sag, concealed by the vast San Juan volcanic field of south-central Colorado, has only recently benefited from oil and gas wildcat drilling and evaluations. Sound geochemical analyses and maturation modeling are essential elements for successful exploration and development. Oil has been produced in minor quantities from an Oligocene sill in the Mancos Shale within the sag, and major oil and gas production occurs from stratigraphically equivalent rocks in the San Juan basin to the south-west and in the Denver basin to the northeast. The objectives of this study were to identify potential source rocks, assess thermal maturity, and determine hydrocarbon-source bed relationships. Source rocks are present in the San Juan sag in the upper and lower Mancos Shale (including the Niobrara Member), which consists of about 666 m (2184 ft) of marine shale with from 0.5 to 3.1 wt. % organic carbon. Pyrolysis yields (S1 + S2 = 2000-6000 ppm) and solvent extraction yields (1000-4000 ppm) indicate that some intervals within the Mancos Shale are good potential source rocks for oil, containing type II organic matter, according to Rock-Eval pyrolysis assay. Oils produced from the San Juan sag and adjacent part of the San Juan basin are geochemically similar to rock extracts obtained from these potential source rock intervals. Based on reconstruction of the geologic history of the basin integrated with models of organic maturation, we conclude that most of the source rock maturation occurred in the Oligocene and Miocene. Little to no maturation took place during Laramide subsidence of the basin, when the Animas and Blanco Basin formations were deposited. The timing of maturation is unlike that of most Laramide basins in the Rocky Mountain region, where maturation occurred as a result of Paleocene and Eocene basin fill. The present geothermal gradient in the San Juan sag is slightly higher (average 3.5??C/100 m; 1.9??F/100 ft) than the regional average for southern Rocky

  4. Propagation as a mechanism of reorientation of the Juan de Fuca ridge

    NASA Technical Reports Server (NTRS)

    Wilson, D. S.; Hey, R. N.; Nishimura, C.

    1984-01-01

    A revised model is presented of the tectonic evolution of the Juan de Fuca ridge by propagating rifting. The new model has three different relative rotation poles, covering the time intervals 17.0-8.5 Ma, 8.5-5.0 Ma, and 5.0 Ma to the present. The rotation pole shifts at 8.5 and 5.0 Ma imply clockwise shifts in the direction of relative motion of 10 deg to 15 deg. At each of these shifts, the pattern of propagation reorganizes, and the new ridges formed by propagation are at an orientation closer to orthogonal to the new direction of motion than the orientation of the preexisting ridges. The model, containing a total of seven propagation sequences, shows excellent agreement with the isochrons inferred from the magnetic anomaly data, except in areas complicated by the separate Explorer and Gorda plates. The agreement between model and data near the Explorer plate breaks down abruptly at an age of about 5 Ma, indicating that the probable cause of the rotation pole shift at that time was the separation of the Explorer plate from the Juan de Fuca plate.

  5. Tomographic imaging of the Cascadia subduction zone: Constraints on the Juan de Fuca slab

    NASA Astrophysics Data System (ADS)

    Chen, Chuanxu; Zhao, Dapeng; Wu, Shiguo

    2015-04-01

    We used 40,343 P-wave arrival times from 1883 local earthquakes and 105,455 P-wave arrivals from 6361 teleseismic events to study the detailed structure of the Cascadia subduction zone. We conducted tomographic inversions using a starting velocity model which includes the high-velocity subducting Juan de Fuca slab as a priori information. A number of such slab-constrained inversions are conducted by changing the slab thickness and the velocity contrast between the slab and the surrounding mantle. Our optimal 3-D velocity model fits the data much better than that determined by an inversion with a 1-D homogeneous starting model. Our results show that the subducting Juan de Fuca slab has a thickness of 30-50 km and a P-wave velocity of 1-3% higher than that of the surrounding mantle. Beneath the northern and southern parts of the Cascadia, P-wave velocity is lower in the slab and along the slab interface, which may reflect a more hydrated slab and more active slab dehydration there. The lateral velocity variations may indicate different degrees of slab dehydration and forearc mantle serpentinization. The segmentation in episodic tremor and slip (ETS) is also spatially coincident with the velocity heterogeneities, indicating that the ETS occurrence and recurrence interval are controlled by fluid activity in and around the mantle wedge corner.

  6. Progressive migration and anagenesis in Drimys confertifolia of the Juan Fernández Archipelago, Chile.

    PubMed

    López-Sepúlveda, Patricio; Takayama, Koji; Greimler, Josef; Crawford, Daniel J; Peñailillo, Patricio; Baeza, Marcelo; Ruiz, Eduardo; Kohl, Gudrun; Tremetsberger, Karin; Gatica, Alejandro; Letelier, Luis; Novoa, Patricio; Novak, Johannes; Stuessy, Tod F

    2015-01-01

    A common mode of speciation in oceanic islands is by anagenesis, wherein an immigrant arrives and through time transforms by mutation, recombination, and drift into a morphologically and genetically distinct species, with the new species accumulating a high level of genetic diversity. We investigate speciation in Drimys confertifolia, endemic to the two major islands of the Juan Fernández Archipelago, Chile, to determine genetic consequences of anagenesis, to examine relationships among populations of D. confertifolia and the continental species D. winteri and D. andina, and to test probable migration routes between the major islands. Population genetic analyses were conducted using AFLPs and nuclear microsatellites of 421 individuals from 42 populations from the Juan Fernández islands and the continent. Drimys confertifolia shows a wide genetic variation within populations on both islands, and values of genetic diversity within populations are similar to those found within populations of the continental progenitor. The genetic results are compatible with the hypothesis of high levels of genetic variation accumulating within anagenetically derived species in oceanic islands, and with the concept of little or no geographical partitioning of this variation over the landscape. Analysis of the probability of migration within the archipelago confirms colonization from the older island, Robinson Crusoe, to the younger island Alejandro Selkirk.

  7. Vacuolate-attached filaments: highly productive Ridgeia piscesae epibionts at the Juan de Fuca hydrothermal vents.

    PubMed

    Kalanetra, Karen M; Nelson, Douglas C

    2010-01-01

    Vacuolate sulfur bacteria with high morphological similarity to vacuolate-attached filaments previously described from shallow hydrothermal vents (White Point, CA) were found at deep-sea hydrothermal vents. These filamentous bacteria grow in dense mats that cover surfaces and potentially provide a significant source of organic carbon where they occur. Vacuolate-attached filaments were collected near vents at the Clam Bed site of the Endeavour Segment of the Juan de Fuca Ridge and from the sediment surface at Escanaba Trough on the Gorda Ridge. A phylogenetic analysis comparing their 16S rRNA gene sequences to those collected from the shallow White Point site showed that all vacuolate-attached filament sequences form a monophyletic group within the vacuolate sulfur-oxidizing bacteria clade in the gamma proteobacteria. Abundance of the attached filaments was quantified over the length of the exterior surface of the tubes of Ridgeia piscesae worms collected from the Clam Bed site at Juan de Fuca yielding a per worm average of 0.070 ± 0.018 cm(3) (n = 4). In agreement with previous results for White Point filaments, anion measurements by ion chromatography showed no detectable internal nitrate concentrations above ambient seawater (n = 9). For one R. piscesae tube worm "bush" at the Easter Island vent site, potential gross epibiont productivity is estimated to be 15 to 45× the net productivity of the worms.

  8. A Geo-referenced 3D model of the Juan de Fuca Slab and associated seismicity

    USGS Publications Warehouse

    Blair, J.L.; McCrory, P.A.; Oppenheimer, D.H.; Waldhauser, F.

    2011-01-01

    We present a Geographic Information System (GIS) of a new 3-dimensional (3D) model of the subducted Juan de Fuca Plate beneath western North America and associated seismicity of the Cascadia subduction system. The geo-referenced 3D model was constructed from weighted control points that integrate depth information from hypocenter locations and regional seismic velocity studies. We used the 3D model to differentiate earthquakes that occur above the Juan de Fuca Plate surface from earthquakes that occur below the plate surface. This GIS project of the Cascadia subduction system supersedes the one previously published by McCrory and others (2006). Our new slab model updates the model with new constraints. The most significant updates to the model include: (1) weighted control points to incorporate spatial uncertainty, (2) an additional gridded slab surface based on the Generic Mapping Tools (GMT) Surface program which constructs surfaces based on splines in tension (see expanded description below), (3) double-differenced hypocenter locations in northern California to better constrain slab location there, and (4) revised slab shape based on new hypocenter profiles that incorporate routine depth uncertainties as well as data from new seismic-reflection and seismic-refraction studies. We also provide a 3D fly-through animation of the model for use as a visualization tool.

  9. Sub-Seafloor Carbon Dioxide Storage Potential on the Juan de Fuca Plate, Western North America

    SciTech Connect

    Jerry Fairley; Robert Podgorney

    2012-11-01

    The Juan de Fuca plate, off the western coast of North America, has been suggested as a site for geological sequestration of waste carbon dioxide because of its many attractive characteristics (high permeability, large storage capacity, reactive rock types). Here we model CO2 injection into fractured basalts comprising the upper several hundred meters of the sub-seafloor basalt reservoir, overlain with low-permeability sediments and a large saline water column, to examine the feasibility of this reservoir for CO2 storage. Our simulations indicate that the sub-seafloor basalts of the Juan de Fuca plate may be an excellent CO2 storage candidate, as multiple trapping mechanisms (hydrodynamic, density inversions, and mineralization) act to keep the CO2 isolated from terrestrial environments. Questions remain about the lateral extent and connectivity of the high permeability basalts; however, the lack of wells or boreholes and thick sediment cover maximize storage potential while minimizing potential leakage pathways. Although promising, more study is needed to determine the economic viability of this option.

  10. Cancer screening participation: comparative willingness of San Juan Puerto Ricans versus New York City Puerto Ricans.

    PubMed Central

    Claudio, Cristina; Katz, Ralph V.; Green, B. Lee; Kressin, Nancy R.; Wang, Min Qi; Russell, Stefanie L.

    2007-01-01

    OBJECTIVES: The specific aim of this study was to determine the self-reported likelihood of New York Puerto Ricans (NYPR) and San Juan Puerto Ricans (SJPR) to participate in: 10 site-specific cancer screenings, cancer-screenings conducted by different specific persons/agencies and cancer-screening under specific conditions of what one was asked to do as a part of cancer screening. METHODS: The Cancer Screening Questionnaire (CSQ) was administered via random-digit-dial telephone interviews to 154 adults living in San Juan, PR and 155 in New York, NY. RESULTS: Although the self-reported willingness to participate across the 10 site-specific cancer screening exams was consistently high in both cities, SJPR had higher rates, as compared to NYPR for all 10 site-specific cancer screening exams in the unadjusted analyses. A similar pattern was observed regarding the influence of both "who conducts the cancer-screening exam" and "what one is asked to do in a cancer-screening exam" as factors in the willingness to participate in such exams. Adjusted multivariate analysis showed that the odds of SJPR participating in skin cancer screening as compared to NYPR, were three-fold higher to participate in skin cancer screening and were two-fold higher to participate in a cancer screening where they have to be interviewed about their alcohol habits. These two observed differences might reflect the effect of acculturation in the NYPR. PMID:17534012

  11. Modelling aftershock migration and afterslip of the San Juan Bautista, California, earthquake of October 3, 1972

    USGS Publications Warehouse

    Wesson, R.L.

    1987-01-01

    The San Juan Bautista earthquake of October 3, 1972 (ML = 4.8), located along the San Andreas fault in central California, initiated an aftershock sequence characterized by a subtle, but perceptible, tendency for aftershocks to spread to the northwest and southeast along the fault zone. The apparent dimension of the aftershock zone along strike increased from about 7-10 km within a few days of the earthquake, to about 20 km eight months later. In addition, the mainshock initiated a period of accelerated fault creep, which was observed at 2 creep meters situated astride the trace of the San Andreas fault within about 15 km of the epicenter of the mainshock. The creep rate gradually returned to the preearthquake rate after about 3 yrs. Both the spreading of the aftershocks and the rapid surface creep are interpreted as reflecting a period of rapid creep in the fault zone representing the readjustment of stress and displacement following the failure of a "stuck" patch or asperity during the San Juan Bautista earthquake. Numerical calculations suggest that the behavior of the fault zone is consistent with that of a material characterized by a viscosity of about 3.6??1014 P, although the real rheology is likely to be more complicated. In this model, the mainshock represents the failure of an asperity that slips only during earthquakes. Aftershocks represent the failure of second-order asperities which are dragged along by the creeping fault zone. ?? 1987.

  12. Pb, Sr, and Nd isotopes in basalts and sulfides from the Juan de Fuca Ridge

    SciTech Connect

    Hegner, E.; Tatsumoto, M.

    1987-10-10

    Pb, Sr, Nd isotopes of seven basalt glasses collected by the submersible Alvin from the southern Juan de Fuca Ridge (SJFR) are almost identical (/sup 206/Pb//sup 204/Pbapprox.18.45, /sup 207/Pb//sup 204/Pbapprox.15.47, /sup 208/Pb//sup 204/Pbapprox.37.81, /sup 87/Sr//sup 86/Srapprox.0.70249, /sup 143/Nd//sup 144/Ndapprox.0.51315). Whereas all basalts appear cogenetic, four of the samples have uniform abundances of U, Th, Rb, Nd, Sm, Pb, and Sr, indicating that they are also comagmatic. Two basalt glasses dredged previously at the SJFR have similar isotopic compositions but higher concentrations of U, Th, and Pb. The /sup 206/Pb//sup 204/Pb ratios are intermediate between generally less radiogenic ridge basalts from south of the Juan de Fuca Ridge (JFR) and often more radiogenic basalts from the northern JFR and NE Pacific seamounts. Sr and Nd isotopic compositions closely resemble data of other ridge basalts from the northernmost East Pacific Rise and are intermediate between isotopically more diverse seamount basalts produced nearby.

  13. Application of an area of review variance methodology to the San Juan Basin, New Mexico

    SciTech Connect

    Dunn-Norman, S.; Warner, D.L.; Koederitz, L.F.; Laudon, R.C.

    1995-12-01

    When the Underground Injection Control (UIC) Regulations were promulgated in 1980, existing Class II Injection wells operating at the time were excluded from Area of Review (AOR) requirements. EPA has expressed its intent to revise the regulations to include the requirement for AOR`s for such wells, but it is expected that oil and gas producing states will be allowed to adopt a variance strategy for these wells. An AOR variance methodology has been developed under sponsorship of the American Petroleum Institute. The general concept of the variance methodology is a systematic evaluation of basic variance criteria that were agreed to by a Federal Advisory Committee. These criteria include absence of USDWs, lack of positive flow potential from the petroleum reservoir into the overlying USDWs, mitigating geological factors, and other evidence. The AOR variance methodology has been applied to oilfields in the San Juan Basin, New Mexico. This paper details results of these analyses, particularly with respect to the opportunity for variance for injection fields in the San Juan Basin.

  14. Imaging the Juan de Fuca plate beneath southern Oregon using teleseismic P wave residuals

    USGS Publications Warehouse

    Harris, R.A.; Iyer, H.M.; Dawson, P.B.

    1991-01-01

    Images the Juan de Fuca plate in southern Oregon using seismic tomography. P wave travel time residuals from a 366-km-long seismic array operated in southern Oregon in 1982 are inverted. The southeast striking array extended from the Coast ranges to the Modoc Plateau and crossed the High Cascades at Crater Lake, Oregon. Three features under the array were imaged: one high-velocity zone and two low-velocity zones. The high-velocity zone is 3-4% faster than the surrounding upper mantle. It dips steeply at 65?? to the east beneath the Cascade Range and extends down to at least 200 km. It is proposed that this high-velocity feature is subducted Juan de Fuca plate. Two low-velocity zones were also imaged, both of which are 3-4% slower than the surrounding earth structure. The southeastern low-velocity zone may be caused by partially molten crust underlying the Crater Lake volcano region. -from Authors

  15. Dinosaur Footprints in Lower Cretaceous Beds in San Juan Raya, Southern Mexico and the Paleoenvironmental Implications

    NASA Astrophysics Data System (ADS)

    Aceves, D.

    2008-12-01

    Dinosaur footprints were traced at San Juan Raya, an important site in Mexico, a world fossil site. This site is found at South-west of the State of Puebla, within the Biosphere Reserve of Tehuacan-Cuitcatlán, to the southwest of the Tehuacan valley. These footprints were recorded by tracing them on transparent paper at Barranca Agua Nueva, at point 18°18.56´N 97°37´W. Using Jacob´s staff a stratigraphic register was generated from 50 m ascending and descending in stratigraphically direction from the bed where footprints were founded. Bivalbes, nerineas, shell fragments, and trigonias were founded in this sequence as well as cross bedding of clays and fine grain sand, some which display ripples. Fifty two footprints were recorded and five different tracks identified, observing two different sizes. The tracks of dinosaur footprints present the common Teropode ichnites. The succession where dinosaur footprints have been found, are interpreted as a peritidal environment. This investigation contributes to an eco-tourism project of San Juan Raya.

  16. The intrinsic and interactive effects of RO 15-4513 and ethanol on locomotor activity, body temperature, and blood glucose concentration

    SciTech Connect

    Wood, A.L.; Healey, P.A.; Menendez, J.A.; Verne, S.L.; Atrens, D.M. )

    1989-01-01

    The ability of the putative ethanol antagonist RO 15-4513 to antagonize ethanol-induced hypoactivity, hypothermia and hyperglycemia was investigated in rats. Although RO 15-4513 produced hypoactivity by itself, it attenuated ethanol-induced hypoactivity. This antagonism suggests that ethanol-induced hypoactivity is mediated by the GABA-benzodiazepine receptor complex which is thought to be the site of action of RO 15-4513. In contrast, although RO 15-4513 produced hypothermia by itself, it had no significant effect on ethanol-induced hypothermia. This suggests that the hypothermic effect of ethanol is not mediated by the GABA-benzodiazepine receptor complex. The fact that RO 15-4513, ethanol and the vehicle all produced hyperglycemia suggests a common stress effect and does not permit any firm conclusions to be drawn as to the interaction between ethanol and RO 15-4513 in modulating glycemic responses. These data indicate that the ethanol antagonism of RO 15-4513 is primarily confined to ethanol's behavioral effects and that ethanol's behavioral and physiological effects are mediated by neurochemically distinct mechanisms.

  17. Receptor binding characterization of the benzodiazepine radioligand sup 125 I-Ro16-0154: Potential probe for SPECT (Single Photon Emission Computed Tomography) brain imaging

    SciTech Connect

    Johnson, E.W.; Woods, S.W.; Zoghbi, S.; Baldwin, R.M.; Innis, R.B. ); McBride, B.J. )

    1990-01-01

    The binding of an iodinated benzodiazepine (BZ) radioligand has been characterized, particularly in regard to its potential use as a neuroreceptor brain imaging agent with SPECT (Single Photon Emission Computed Tomography). Ro16-0154 is an iodine-containing BZ antagonist and a close analog of Ro15-1788. In tissue homogenates prepared from human and monkey brain, the binding of {sup 125}I-labeled Ro16-0154 was saturable, of high affinity, and had high ratios of specific to non-specific binding. Physiological concentrations of NaCl enhanced specific binding approximately 15% compared to buffer without this salt. Kinetic studies of association and dissociation demonstrated a temperature dependent decrease in affinity with increasing temperature. Drug displacement studies confirmed that {sup 125}I-Ro16-0154 binds to the central type BZ receptor: binding is virtually identical to that of {sup 3}H-Ro15-1788 except that {sup 125}I-Ro16-0154 shows an almost 10 fold higher affinity at 37{degree}C. These in vitro results suggest that {sup 123}I-labeled Ro16-0154 shows promise as a selective, high affinity SPECT probe of the brain's BZ receptor.

  18. SDN based millimetre wave radio over fiber (RoF) network

    NASA Astrophysics Data System (ADS)

    Amate, Ahmed; Milosavljevic, Milos; Kourtessis, Pandelis; Robinson, Matthew; Senior, John M.

    2015-01-01

    This paper introduces software-defined, millimeter Wave (mm-Wave) networks with Radio over Fiber (RoF) for the delivery of gigabit connectivity required to develop fifth generation (5G) mobile. This network will enable an effective open access system allowing providers to manage and lease the infrastructure to service providers through unbundling new business models. Exploiting the inherited benefits of RoF, complete base station functionalities are centralized at the edges of the metro and aggregation network, leaving remote radio heads (RRHs) with only tunable filtering and amplification. A Software Defined Network (SDN) Central Controller (SCC) is responsible for managing the resource across several mm-Wave Radio Access Networks (RANs) providing a global view of the several network segments. This ensures flexible resource allocation for reduced overall latency and increased throughput. The SDN based mm-Wave RAN also allows for inter edge node communication. Therefore, certain packets can be routed between different RANs supported by the same edge node, reducing latency. System level simulations of the complete network have shown significant improvement of the overall throughput and SINR for wireless users by providing effective resource allocation and coordination among interfering cells. A new Coordinated Multipoint (CoMP) algorithm exploiting the benefits of the SCC global network view for reduced delay in control message exchange is presented, accounting for a minimum packet delay and limited Channel State Information (CSI) in a Long Term Evolution-Advanced (LTE-A), Cloud RAN (CRAN) configuration. The algorithm does not require detailed CSI feedback from UEs but it rather considers UE location (determined by the eNB) as the required parameter. UE throughput in the target sector is represented using a Cumulative Distributive Function (CDF). The drawn characteristics suggest that there is a significant 60% improvement in UE cell edge throughput following the

  19. Chemistry of silica scale mitigation for RO desalination with particular reference to remote operations.

    PubMed

    Milne, Nicholas A; O'Reilly, Tom; Sanciolo, Peter; Ostarcevic, Eddy; Beighton, Mark; Taylor, Kelvin; Mullett, Mark; Tarquin, Anthony J; Gray, Stephen R

    2014-11-15

    Silica scaling in reverse osmosis of groundwater is a significant issue in water stressed areas due to the limitations that scaling imposes on water recovery. While calcium and magnesium scaling potential can be significantly reduced by the use of ion exchange or other softening processes, the silica scaling potential typically remains. Improving the recovery of reverse osmosis by limiting the potential for silica scale is important in ensuring maximum water recovery. This is particularly important for mining and natural gas industries that are located in remote regions. The remote nature of these sites imposes three major restrictions on the silica scale mitigation process. Firstly, the generation of poorly dewaterable sludges must be avoided. Also, the quality of any reverse osmosis (RO) permeate must be able to meet the end use requirements, particularly for boilers. Finally, silica removal should not impact upon other potentially useful or valuable components within the brine, and should not make the disposal of the unusable waste brine components more difficult. Reduction of scaling potential can be achieved in three main ways: operating RO at high pH after hardness has been removed, operating at low pH, and reducing the silica concentration either in pretreatment or by using an interstage technique. Operating at high pH has the initial requirement of hardness removal to prevent scaling and this could be an issue on some sites. Hardness removal operations that use ion exchange resins may be challenged by water chemistry and the operational costs associated with high chemical regeneration costs. Operating at low pH may be more desirable than high pH operation as this can help to reduce the risk of scale formation from calcium or magnesium salts. The drawback comes from the cost of acid, particularly for high-alkalinity waters. There are numerous silica removal techniques including chemical dosing of lime, or aluminium or iron salts, electrocoagulation

  20. AST/RO Observations of CO J=7-6 Emission from the Galactic Center

    NASA Astrophysics Data System (ADS)

    Kim, S.; Martin, C. L.; Stark, A. A.; Lane, A. P.

    2000-12-01

    We present a map of the Galactic Center region in the CO J=7-6 transition observed with the Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) located at Amundsen-Scott South Pole Station. Emission from the 809 GHz J=7-6 transition of 12CO was mapped over the region -2.7 < l < 3.6, -1.0 < b < 1.0, on a 1' grid with a spatial resolution of ~ 85''. The CO J=4-3 and [CI] emissions from this region have been mapped with AST/RO by Martin et al. (2001) and Ojha et al. (2000). These two spectral lines are distributed throughout the Galactic Center region in a manner almost identical to that of CO J=1-0; the CO(4-3)/ CO(1-0) line ratio and the [CI]/CO line ratios are remarkably uniform across a wide variety of Galactic Center features. In contrast, the CO J=7-6 emission from the Galactic Center region is confined to the Sgr A and Sgr B2 complexes. The implication is that the photon-dominated regions surrounding the Galactic Center are remarkably similar in mean density and kinetic temperature at n = 3000 cm-3 and T = 35 K, except for the two special regions Sgr A and Sgr B2, which are denser. The CO(7-6)/CO(4-3) line temperature ratios near Sgr B2 are similar to those observed in the nuclear region of the starburst galaxy M82 (Mao et al. 2000), while the CO(7-6)/CO(4-3) line temperature ratios around Sgr A are a factor of three lower than those near Sgr B2. The CO(7-6)/CO(4-3) line ratio in the Galactic Center region as a whole is at least an order of magnitude less than that in a comparable region near the center of M82. This research was supported in part by the National Science Foundation under a cooperative agreement with the Center for Astrophysical Research in Antarctica (CARA), grant number NSF OPP 89-20223. CARA is a National Science Foundation Science and Technology Center.

  1. Disentangling planetary and stellar activity features in the CoRoT-2 light curve

    NASA Astrophysics Data System (ADS)

    Bruno, G.; Deleuil, M.; Almenara, J.-M.; Barros, S. C. C.; Lanza, A. F.; Montalto, M.; Boisse, I.; Santerne, A.; Lagrange, A.-M.; Meunier, N.

    2016-11-01

    Aims: Stellar activity is an important source of systematic errors and uncertainties in the characterization of exoplanets. Most of the techniques used to correct for this activity focus on an ad hoc data reduction. Methods: We have developed a software for the combined fit of transits and stellar activity features in high-precision long-duration photometry. Our aim is to take advantage of the modelling to derive correct stellar and planetary parameters, even in the case of strong stellar activity. Results: We use an analytic approach to model the light curve. The code KSint, modified by adding the evolution of active regions, is implemented into our Bayesian modelling package PASTIS. The code is then applied to the light curve of CoRoT-2. The light curve is divided in segments to reduce the number of free parameters needed by the fit. We perform a Markov chain Monte Carlo analysis in two ways. In the first, we perform a global and independent modelling of each segment of the light curve, transits are not normalized and are fitted together with the activity features, and occulted features are taken into account during the transit fit. In the second, we normalize the transits with a model of the non-occulted activity features, and then we apply a standard transit fit, which does not take the occulted features into account. Conclusions: Our model recovers the activity features coverage of the stellar surface and different rotation periods for different features. We find variations in the transit parameters of different segments and show that they are likely due to the division applied to the light curve. Neglecting stellar activity or even only bright spots while normalizing the transits yields a 1.2σ larger and 2.3σ smaller transit depth, respectively. The stellar density also presents up to 2.5σ differences depending on the normalization technique. Our analysis confirms the inflated radius of the planet (1.475 ± 0.031RJ) found by other authors. We show that

  2. Variational Calculations of IR Ro-Vibrational Spectra for Nitric Acid

    NASA Astrophysics Data System (ADS)

    Pavlyuchko, A. I.; Yurchenko, S. N.; Tennyson, J.

    2013-09-01

    To model the atmospheric composition of the potentially habitable planets, it is essential to have comprehensive data on the spectroscopic properties of the main molecular absorbers. This is especially true in the infrared region which is dominated by transitions of polyatomic molecules [1]. Nitric acid (HNO3) is an important constituent of the Earth atmosphere where it is a prominent bio-signature. Here we present simulations of the absorption spectra for HNO3. We have developed a variational method to solve the ro-vibrational Schrödinger equation for a general polyatomic molecule. The ro-vibrational Hamiltonian is given by [2] where the internal curvilinear vibrational coordinates qi are used to represent the displacements of the bond lengths and bond angles, ?ij(q) are elements of the matrix of the kinematic coefficients, t is the determinant of this matrix, 'a are the Euler angles, and μab(q) is the inverse matrix of the tensor of inertia. The potential energy function, V (q), is given by a fourthorder polynomial expansion in terms of Morse variables xi = 1 - e-iqi for the stretching coordinates and xi = qi for the bending coordinates. The dipole moment of the molecule is presented in the form of a Taylor series of the 2nd order in terms of qi. The parameters of the potential energy and the dipole moment functions of HNO3 were calculated by the quantum chemical method at the CCSD(T)/aug-cc-pVQZ level of theory. With this potential energy function, agreement between the calculated and experimental fundamental frequencies of vibrations is within 5 cm -1. The harmonic part of the potential function was then optimized by fitting to the experimental fundamental frequencies and used to simulate the IR spectra of HNO3. The results are in good agreement with the experimental data. The figure shows an example of the simulated spectra of HNO3 in the area of the strong Fermi resonance between the -5 and 2-9 bands along with an experimental counterpart. The resulting

  3. The roAp star α Circinus as seen by BRITE-Constellation

    NASA Astrophysics Data System (ADS)

    Weiss, W. W.; Fröhlich, H.-E.; Pigulski, A.; Popowicz, A.; Huber, D.; Kuschnig, R.; Moffat, A. F. J.; Matthews, J. M.; Saio, H.; Schwarzenberg-Czerny, A.; Grant, C. C.; Koudelka, O.; Lüftinger, T.; Rucinski, S. M.; Wade, G. A.; Alves, J.; Guedel, M.; Handler, G.; Mochnacki, St.; Orleanski, P.; Pablo, B.; Pamyatnykh, A.; Ramiaramanantsoa, T.; Rowe, J.; Whittaker, G.; Zawistowski, T.; Zocłońska, E.; Zwintz, K.

    2016-04-01

    We report on an analysis of high-precision, multi-colour photometric observations of the rapidly-oscillating Ap (roAp) star α Cir. These observations were obtained with the BRITE-Constellation, which is a coordinated mission of five nanosatellites that collects continuous millimagnitude-precision photometry of dozens of bright stars for up to 180 days at a time in two colours (≈Johnson B and R). BRITE stands for BRight Target Explorer. The object α Cir is the brightest roAp star and an ideal target for such investigations, facilitating the determination of oscillation frequencies with high resolution. This star is bright enough for complementary interferometry and time-resolved spectroscopy. Four BRITE satellites observed α Cir for146 d or 33 rotational cycles. Phasing the photometry according to the 4.4790 d rotational period reveals qualitatively different light variations in the two photometric bands. The phased red-band photometry is in good agreement with previously-published WIRE data, showing a light curve symmetric about phase 0.5 with a strong contribution from the first harmonic. The phased blue-lband data, in contrast, show an essentially sinusoidal variation. We model both light curves with Bayesian Photometric Imaging, which suggests the presence of two large-scale, photometrically bright (relative to the surrounding photosphere) spots. We also examine the high-frequency pulsation spectrum as encoded in the BRITE photometry. Our analysis establishes the stability of the main pulsation frequency over the last ≈20 yr, confirms the presence of frequency f7, which was not detected (or the mode not excited) prior to 2006, and excludes quadrupolar modes for the main pulsation frequency. Based on data collected by the BRITE-Constellation satellite mission, built, launched and operated thanks to support from the Austrian Aeronautics and Space Agency, the University of Vienna, the Canadian Space Agency (CSA), the Foundation for Polish Science

  4. Standardization of vitrinite reflectance measurements in shale petroleum systems: How accurate are my Ro data?

    USGS Publications Warehouse

    Hackley, Paul C.

    2014-01-01

    Vitrinite reflectance generally is considered the most robust thermal maturity parameter available for application to hydrocarbon exploration and petroleum system evaluation. However, until 2011 there was no standardized methodology available to provide guidelines for vitrinite reflectance measurements in shale. Efforts to correct this deficiency resulted in publication of ASTM D7708-11: Standard test method for microscopical determination of the reflectance of vitrinite dispersed in sedimentary rocks. In 2012-2013, an interlaboratory exercise was conducted to establish precision limits for the measurement technique. Six samples, representing a wide variety of shale, were tested in duplicate by 28 analysts in 22 laboratories from 14 countries. Samples ranged from immature to overmature (Ro 0.31-1.53%), from organic-rich to organic-lean (1-22 wt.% total organic carbon), and contained Type I (lacustrine), Type II (marine), and Type III (terrestrial) kerogens. Repeatability values (difference between repetitive results from same operator, same conditions) ranged from 0.03-0.11% absolute reflectance, whereas reproducibility values (difference between results obtained on same test material by different operators, different laboratories) ranged from 0.12-0.54% absolute reflectance. Repeatability and reproducibility degraded consistently with increasing maturity and decreasing organic content. However, samples with terrestrial kerogens (Type III) fell off this trend, showing improved levels of reproducibility due to higher vitrinite content and improved ease of identification. Operators did not consistently meet the reporting requirements of the test method, indicating that a common reporting template is required to improve data quality. The most difficult problem encountered was the petrographic distinction of solid bitumens and low-reflecting inert macerals from vitrinite when vitrinite occurred with reflectance ranges overlapping the other components. Discussion among

  5. Inhibitory Effects of Cytosolic Ca2+ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets

    PubMed Central

    Kwon, Hyuk-Woo; Shin, Jung-Hae; Lee, Dong-Ha; Park, Hwa-Jin

    2015-01-01

    Intracellular Ca2+ ([Ca2+]i) is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca2+-antagonistic effect of ginsenoside Ro (G-Ro), an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca2+]i, which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI) (Ser1756) to inhibit [Ca2+]i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser1756) by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa), indicating inhibition of Ca2+ influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP3RI (Ser1756) phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa) to decrease thrombin-elevated [Ca2+]i, which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca2+-antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease. PMID:26355658

  6. Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen.

    PubMed Central

    Ben-Chetrit, E; Gandy, B J; Tan, E M; Sullivan, K F

    1989-01-01

    SS-A/Ro is a nucleocytoplasmic ribonucleoprotein (RNP) particle that is a common target of autoimmune response in Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). Previously, SS-A/Ro has been shown to be composed of at least two polypeptide antigens of 60 and 52 kD noncovalently associated with a set of small RNAs, designated Y1-Y5. A serum from an SS patient was selected to screen a lambda gt11 cDNA library constructed from human T cell lymphoblastic leukemia (MOLT-4) mRNA. An immunoreactive clone was isolated that possessed a 1.8-kb cDNA insert. In vitro transcription and translation of the cDNA resulted in the synthesis of a 57.5-kD polypeptide which was specifically immunoprecipitated by SS-A/Ro antisera. The identity of the cDNA encoded protein as the 60-kD SS-A/Ro antigen was established by proteolytic peptide mapping of the cDNA-encoded protein and the 60-kD HeLa cell antigen. The sequence of the cDNA shows that the 60-kD SS-A/Ro protein possesses both RNA binding protein consensus sequences and a single zinc-finger motif. Recombinant SS-A/Ro antigen produced in bacteria proved to be a sensitive and specific reagent for detection of anti-SS-A/Ro antibodies in patient sera. The availability of the 60-kD SS-A/Ro cDNA will enable detailed analysis of the molecular structure and function of the SS-A/Ro RNP particle and its role in autoimmune pathology. Images PMID:2649513

  7. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    NASA Astrophysics Data System (ADS)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  8. Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes.

    PubMed

    Bollag, W B; Ducote, J; Harmon, C S

    1993-03-01

    We have investigated the effects of Ro 31-7549, a selective protein kinase C (PKC) inhibitor, on DNA synthesis and proliferation in two primary mouse epidermal keratinocyte culture systems. In differentiating keratinocytes incubated in medium containing 10% serum and high calcium (approximately 0.5 mM), Ro 31-7549 blocked the inhibitory effect of the phorbol ester 12-0-tetradecanoyl-13-acetate (TPA) (a PKC activator) on keratinocyte DNA synthesis at 24 h [50% maximal response concentration (EC50) = 1 microM], consistent with inhibition of PKC-mediated differentiation. Continuous treatment of the differentiative culture system with the PKC inhibitor resulted in a marked (fourfold) stimulation of [3H]thymidine incorporation at day 7 of exposure, with an EC50 of 0.25 microM. The potencies of these effects of Ro 31-7549 are comparable to that reported for inhibition of TPA-induced platelet 47-kD protein phosphorylation [50% inhibitory concentration (IC50) = 4.4 microM]. The time course of [3H]thymidine incorporation indicated that Ro 31-7549 did not directly stimulate DNA synthesis but instead prevented the loss of proliferative capacity associated with continued culture in this medium. Maximal stimulation (2.6 times) of DNA synthesis was observed on day 4, whereas DNA synthesis at day 1 was unaffected. In a highly proliferative culture system using serum-free medium containing 25 microM calcium, TPA dose-dependently inhibited proliferation with an IC50 of approximately 0.3 mM. This antiproliferative effect of TPA was largely reversed by 0.1 microM Ro 31-7549. In the proliferative culture system, 0.75 microM Ro 31-7549 also essentially reversed the inhibition of proliferation caused by switching to high (1.0 mM) calcium. These results suggest that the loss of proliferative capacity in differentiating epidermal keratinocyte cultures may be mediated, at least in part, by PKC.

  9. Revisiting CoRoT RR Lyrae stars: detection of period doubling and temporal variation of additional frequencies

    NASA Astrophysics Data System (ADS)

    Szabó, R.; Benkő, J. M.; Paparó, M.; Chapellier, E.; Poretti, E.; Baglin, A.; Weiss, W. W.; Kolenberg, K.; Guggenberger, E.; Le Borgne, J.-F.

    2014-10-01

    Context. High-precision, space-based photometric missions like CoRoT and Kepler have revealed new and surprising phenomena in classical variable stars. Such discoveries were the period doubling in RR Lyrae stars and the frequent occurrence of additional periodicities some of which can be explained by radial overtone modes, but others are discordant with the radial eigenfrequency spectrum. Aims: We search for signs of period doubling in CoRoT RR Lyrae stars. The occurrence of this dynamical effect in modulated RR Lyrae stars might help us to gain more information about the mysterious Blazhko effect. The temporal variability of the additional frequencies in representatives of all subtypes of RR Lyrae stars is also investigated. Methods: We preprocess CoRoT light curves by applying trend and jump correction and outlier removal. Standard Fourier technique is used to analyze the frequency content of our targets and follow the time-dependent phenomena. Results: The most comprehensive collection of CoRoT RR Lyrae stars, including new discoveries is presented and analyzed. We found alternating maxima and in some cases half-integer frequencies in four CoRoT Blazhko RR Lyrae stars, as clear signs of the presence of period doubling. This reinforces that period doubling is an important ingredient for understanding the Blazhko effect - a premise we derived previously from the Kepler RR Lyrae sample. As expected, period doubling is detectable only for short time intervals in most modulated RRab stars. Our results show that the temporal variability of the additional frequencies in all RR Lyrae subtypes is ubiquitous. The ephemeral nature and the highly variable amplitude of these variations suggest a complex underlying dynamics of and an intricate interplay between radial and possibly nonradial modes in RR Lyrae stars. The omnipresence of additional modes in all types of RR Lyrae - except in non-modulated RRab stars - implies that asteroseismology of these objects should be

  10. Accretion dynamics and disk evolution in NGC 2264: a study based on CoRoT photometric observations

    NASA Astrophysics Data System (ADS)

    Alencar, S. H. P.; Teixeira, P. S.; Guimarães, M. M.; McGinnis, P. T.; Gameiro, J. F.; Bouvier, J.; Aigrain, S.; Flaccomio, E.; Favata, F.

    2010-09-01

    Context. The young cluster NGC 2264 was observed with the CoRoT satellite for 23 days uninterruptedly in March 2008 with unprecedented photometric accuracy. We present the first results of our analysis of the accreting population belonging to the cluster as observed by CoRoT. Aims: We search for possible light curve variability of the same nature as that observed in the classical T Tauri star AA Tau, which was attributed to a magnetically controlled inner disk warp. The inner warp dynamics is supposed to be directly associated with the interaction between the stellar magnetic field and the inner disk region. Methods: We analyzed the CoRoT light curves of 83 previously known classical T Tauri stars that belong to NGC 2264 classifying them according to their light-curve morphology. We also studied the CoRoT light-curve morphology as a function of a Spitzer-based classification of the star-disk systems. Results: The classification derived on the basis of the CoRoT light-curve morphology agrees very well with the Spitzer IRAC-based classification of the systems. The percentage of AA Tau-like light curves decreases as the inner disk dissipates, from 40% ± 10% in systems with thick inner disks to 36% ± 16% in systems with anemic disks and zero in naked photosphere systems. Indeed, 91% ± 29% of the CTTS with naked photospheres exhibit pure spot-like variability, while only 18% ± 7% of the thick disk systems do so, presumably those seen at low inclination and thus free of variable obscuration. Conclusions: AA Tau-like light curves are found to be fairly common, with a frequency of at least ~30 to 40% in young stars with inner dusty disks. The temporal evolution of the light curves indicates that the structure of the inner disk warp, located close to the corotation radius and responsible for the obscuration episodes, varies over a timescale of a few (~1-3) rotational periods. This probably reflects the highly dynamical nature of the star-disk magnetospheric interaction

  11. Errores sistemáticos del Catálogo Fundamental FK5, deducidos de las observaciones con Astrolabio Fotoeléctrico PAII, en el Hemisferio Sur

    NASA Astrophysics Data System (ADS)

    Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.; González, A.; Gómez, G.

    Se dan los resultados obtenidos de los Errores Sistemáticos del Catálogo Fundamental FK5, Δ α δ, Δ α α, Δ δ α y Δ δ δ, derivados de las observaciones estelares con el Astrolabio Fotoeléctrico PAII del Observatorio de Beijing instalado en el Observatorio Astronómico ``Félix Aguilar'' de San Juan, de acuerdo al Proyecto de Colaboración entre los observatorios de San Juan, Beijing y La Plata. Se han usado los residuos seleccionados de 11000 estrellas aproximadamente, derivados de más de 400000 pasajes estelares en 1550 días, desde Febrero de 1992 a Marzo de 1997. La precisión media de los residuos es de 0,"043.

  12. 77 FR 75145 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Application for Subzone; Sea World, Inc.; Guaynabo, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, Puerto Rico; Application for Subzone; Sea World... for the facility of Sea World, Inc., located in Guaynabo, Puerto Rico. The application was...

  13. 77 FR 63289 - Foreign-Trade Zone 61-San Juan, PR, Application for Subzone, Coamo Property & Investments, LLC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, PR, Application for Subzone, Coamo Property & Investments, LLC, Coamo, PR An application has been submitted to the Foreign-Trade Zones Board (the Board) by... for the facility of Coamo Property & Investments, LLC, located in Coamo, Puerto Rico. The...

  14. Diversity and Abundance of Ammonia-Oxidizing Archaea in Hydrothermal Vent Chimneys of the Juan de Fuca Ridge▿ †

    PubMed Central

    Wang, Shufang; Xiao, Xiang; Jiang, Lijing; Peng, Xiaotong; Zhou, Huaiyang; Meng, Jun; Wang, Fengping

    2009-01-01

    The abundance and diversity of archaeal ammonia monooxygenase subunit A (amoA) genes from hydrothermal vent chimneys at the Juan de Fuca Ridge were investigated. The majority of the retrieved archaeal amoA sequences exhibited identities of less than 95% to those in the GenBank database. Novel ammonia-oxidizing archaea may exist in the hydrothermal vent environments. PMID:19395559

  15. Sequence Stratigraphy of the Dakota Sandstone, Eastern San Juan Basin, New Mexico, and its Relationship to Reservoir Compartmentalization

    SciTech Connect

    Varney, Peter J.

    2002-04-23

    This research established the Dakota-outcrop sequence stratigraphy in part of the eastern San Juan Basin, New Mexico, and relates reservoir quality lithologies in depositional sequences to structure and reservoir compartmentalization in the South Lindrith Field area. The result was a predictive tool that will help guide further exploration and development.

  16. Geology, thermal maturation, and source rock geochemistry in a volcanic covered basin: San Juan sag, south-central Colorado

    SciTech Connect

    Gries, R.R.; Clayton, J.L.; Leonard, C.

    1997-07-01

    The San Juan sag, concealed by the vast San Juan volcanic field of south-central Colorado, has only recently benefited from oil and gas wildcat drilling and evaluations. Sound geochemical analyses and maturation modeling are essential elements for successful exploration and development. Oil has been produced in minor quantities from an Oligocene sill in the Mancos Shale within the sag, and major oil and gas production occurs from stratigraphically equivalent rocks in the San Juan basin to the southwest and in the Denver basin to the northeast. The objectives of this study were to identify potential source rocks, assess thermal maturity, and determine hydrocarbon-source bed relationships. Source rocks are present in the San Juan sag in the upper and lower Mancos Shale (including the Niobrara Member), which consists of about 666 m (2184 ft) of marine shale with from 0.5 to 3.1 wt. % organic carbon. Pyrolysis yields (S{sub 1} + S{sub 2} = 2000-6000 ppm) and solvent extraction yields (1000-4000 ppm) indicate that some intervals within the Mancos Shale are good potential source rocks for oil, containing type II organic matter, according to Rock-Eval pyrolysis assay.

  17. U.S. EPA Releases Monitoring Plan to Evaluate Conditions in the Animas and San Juan Rivers

    EPA Pesticide Factsheets

    WASHINGTON - The U.S. Environmental Protection Agency today released its final monitoring plan for the Animas and San Juan rivers following the Aug. 5, 2015, Gold King Mine incident. The agency also posted on its Gold King Mine website the results o

  18. Juan de Zumarraga; First Bishop of Mexico. The Tinker Pamphlet Series for the Teaching of Mexican American Heritage.

    ERIC Educational Resources Information Center

    Miller, Hubert J.

    The decades of the 1530's and 1540's witnessed the founding of Hispanic colonial institutions, many of which with modifications continue today. Among the most lasting of these has been the Church. This is part of Juan de Zumarraga's (Mexico's first archbishop) legacy, not only the setting up of ecclesiastical administration but also the prelate's…

  19. Culturally Responsive Instruction Leaves No Child Behind: The Story of Juan, a Pacific Island Special Needs Student

    ERIC Educational Resources Information Center

    Stoicovy, Catherine Eileen; Fee, Richard; Fee, Julie

    2012-01-01

    The purpose of this qualitative case study is to explore the use of retelling as a culturally responsive literacy strategy for Juan, a Pacific Island (Chamorro) special needs student on the island of Guam. Data were collected from the following sources: (1) participant-observation (2) fieldnotes (3) audiotaped recordings of students' oral…

  20. 76 FR 23191 - Traffic Separation Schemes: In the Strait of Juan de Fuca and Its Approaches; in Puget Sound and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... SECURITY Coast Guard 33 CFR Part 167 RIN 1625-AA48 Traffic Separation Schemes: In the Strait of Juan de... without change its November 19, 2010, interim rule codifying traffic separation schemes in the Strait of..., and the Strait of Georgia. The Coast Guard established these traffic separation schemes...

  1. 75 FR 70818 - Traffic Separation Schemes: In the Strait of Juan de Fuca and Its Approaches; in Puget Sound and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... SECURITY Coast Guard 33 CFR Part 167 RIN 1625-AA48 Traffic Separation Schemes: In the Strait of Juan de... this interim rule with request for comments, the Coast Guard codifies traffic separation schemes in the..., Boundary Pass, and the Strait of Georgia. These traffic separation schemes (TSSs) were validated by a...

  2. EPA Data Shows Water Quality in San Juan River in the Navajo Nation Back to Pre-Event Levels

    EPA Pesticide Factsheets

    DURANGO, CO - Based on U.S. Environmental Protection Agency (EPA) surface water data collected following the August 5, 2015 Gold King Mine release, San Juan River water quality in Navajo Nation has returned to pre-event conditions. This determinatio

  3. AgRISTARS: Renewable resources inventory. Land information support system implementation plan and schedule. [San Juan National Forest pilot test

    NASA Technical Reports Server (NTRS)

    Yao, S. S. (Principal Investigator)

    1981-01-01

    The planning and scheduling of the use of remote sensing and computer technology to support the land management planning effort at the national forests level are outlined. The task planning and system capability development were reviewed. A user evaluation is presented along with technological transfer methodology. A land management planning pilot test of the San Juan National Forest is discussed.

  4. Writing Virtue and Indigenous Rights: Juan Bautista De Pomar and the "Relación de Texcoco"

    ERIC Educational Resources Information Center

    Espericueta, José

    2015-01-01

    In his "Relación de Texcoco," Juan Bautista de Pomar (c. 1535-90) takes a political and moral stance against Spanish colonialism in Texcoco and the entire viceroyalty of New Spain. Responding to the "Instrucción y memoria's" (1577) request for information about the history and cultural practices of local populations, Pomar…

  5. 77 FR 63290 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Authorization of Production Activity, Pfizer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, Puerto Rico; Authorization of Production Activity, Pfizer Pharmaceuticals, LLC (Subzone 61A), (Ibuprofen Pharmaceutical Products), Guayama,...

  6. 75 FR 62112 - Intent To Prepare an Environmental Impact Statement (EIS) for the San Juan Creek and Tributaries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... Orange County, Feasibility Study. The purpose of this feasibility study is to evaluate flood risk... interim watershed feasibility study was prepared in August 2002. This study will incorporate the prior... San Juan Creek and Tributaries Flood Risk Management Study, Orange County, CA AGENCY: Department...

  7. 33 CFR 161.55 - Vessel Traffic Service Puget Sound and the Cooperative Vessel Traffic Service for the Juan de...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Island, due west to the U.S. Territorial Sea Boundary; thence northward along the U.S. Territorial Sea Boundary to its intersection with the U.S./Canada International Boundary; thence east along the U.S./Canada International Boundary through the waters known as the Strait of Juan de Fuca, Haro Strait, Boundary Pass,...

  8. 33 CFR 161.55 - Vessel Traffic Service Puget Sound and the Cooperative Vessel Traffic Service for the Juan de...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Island, due west to the U.S. Territorial Sea Boundary; thence northward along the U.S. Territorial Sea Boundary to its intersection with the U.S./Canada International Boundary; thence east along the U.S./Canada International Boundary through the waters known as the Strait of Juan de Fuca, Haro Strait, Boundary Pass,...

  9. 33 CFR 161.55 - Vessel Traffic Service Puget Sound and the Cooperative Vessel Traffic Service for the Juan de...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Island, due west to the U.S. Territorial Sea Boundary; thence northward along the U.S. Territorial Sea Boundary to its intersection with the U.S./Canada International Boundary; thence east along the U.S./Canada International Boundary through the waters known as the Strait of Juan de Fuca, Haro Strait, Boundary Pass,...

  10. 33 CFR 161.55 - Vessel Traffic Service Puget Sound and the Cooperative Vessel Traffic Service for the Juan de...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Island, due west to the U.S. Territorial Sea Boundary; thence northward along the U.S. Territorial Sea Boundary to its intersection with the U.S./Canada International Boundary; thence east along the U.S./Canada International Boundary through the waters known as the Strait of Juan de Fuca, Haro Strait, Boundary Pass,...

  11. 33 CFR 161.55 - Vessel Traffic Service Puget Sound and the Cooperative Vessel Traffic Service for the Juan de...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Island, due west to the U.S. Territorial Sea Boundary; thence northward along the U.S. Territorial Sea Boundary to its intersection with the U.S./Canada International Boundary; thence east along the U.S./Canada International Boundary through the waters known as the Strait of Juan de Fuca, Haro Strait, Boundary Pass,...

  12. 78 FR 38359 - Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... approved a Record of Decision for the Final Environmental Impact Statement for the relocation of the Cattle... National Park Service Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island...: Notice of Record of Decision. SUMMARY: Pursuant to Sec. 102(2)(C) of the National Environmental...

  13. Incorporating Ecosystem Services into Community-level Decision-Making: A San Juan, Puerto Rico Case Study

    EPA Science Inventory

    EPA’s Office of Research and Development’s Sustainable and Healthy Communities Research Program is developing tools and approaches to incorporate ecosystem goods and services concepts into community-level decision-making. The San Juan Community Study is one of a serie...

  14. Towards a National Hazard Map of Landslides: Juan de Grijalva, Chiapas, and Mitlatongo, Oaxaca, two catastrophic landslides on southeastern of Mexico

    NASA Astrophysics Data System (ADS)

    Dominguez-M, L.; Castañeda, A.; Ramirez, A.; González, A. E.

    2013-05-01

    and represent two of the most outstanding and representative events in southeastern Mexico. Domínguez L., 2008 "El deslizamiento del 4 de noviembre de 2007 en la comunidad Juan de Grijalva, municipio de Ostuacán, Chiapas, y su relación con el Frente Frio no. 4" Report prepared to the General Coordination of Civil Protection, Ministry of the Interior, Mexico Centro Nacional de Prevención de Desastres, 2009 "Características e impacto socioeconómico de los principales desastres ocurridos en la República Mexicana en el año 2007" Socieconomic Impact by Disasters in Mexico Serie, National System of Civil Protection, Ministry of the Interior, Mexico. Domínguez L., 2011 "Deslizamiento de suelos y rocas en las comunidades de Santiago Mitlatongo, municipio de Nochixtlán, y Santa Cruz Mitlatongo, municipio de Magdalena Jaltepec, Oaxaca" Report prepared to the General Coordination of Civil Protection, Ministry of the Interior, Mexico.

  15. New RO TFC Membranes by Interfacial Polymerization in n-Dodecane with Various co-Solvents

    PubMed Central

    Al-Hobaib, Abdullah Sulaiman; Al-Suhybani, Mohammed Sulaiman; Al-Sheetan, Khalid Mohammed; Mousa, Hasan; Shaik, Mohammed Rafi

    2016-01-01

    The objective of this research is to prepare and characterize a new and highly efficient polyamide TFC RO membrane by interfacial polymerization in dodecane solvent mixed with co-solvents. Three co-solvents were tested namely; acetone, ethyl acetate, and diethyl ether of concentration of 0.5, 1, 2, 3, and 5 wt %. The modified membranes were characterized by SEM, EDX, AFM and contact angle techniques. The results showed that addition of co-solvent results in a decrease in the roughness, pore size and thickness of the produced membranes. However, as the concentration of the co-solvent increases the pore size of the membranes gets larger. Among the three co-solvents tested, acetone was found to result in membranes with the largest pore size and contact angle followed by diethyl ether then ethyl acetate. Measured contact angle increases as the concentration of the co-solvent increases reaching a constant value except for ethyl acetate where it was found to drop. Investigating flux and salt rejection by the formulated membranes showed that higher flux was attained when acetone was used as a co-solvent followed by diethyl ether then ethyl acetate. However, the highest salt rejection was achieved with diethyl ether. PMID:27136591

  16. AST/RO Observations of CO (J=7-6) Emission in NGC 6334

    NASA Astrophysics Data System (ADS)

    Kim, S.; Lane, A. P.; Stark, A. A.; Martin, C. L.; Narayanan, D.; Yan, M.

    2002-05-01

    We present maps of the massive, southern star-forming region NGC6334 in the CO (J=7-6), CO (J=4-3), and 809 GHz [CI] transitions. These lines were observed with the Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) located at Amundsen-Scott South Pole Station. We find two high-excitation CO components on either side of the X-ray emission peak mapped with ASCA (Sekimoto et al. 2000). Our Large Velocity Gradient (LVG) excitation analysis of the line intensity ratios indicates that the photon-dominated regions in NGC6334 have densities of n(H2) ~ 10(3.9-4.2) cm-3 and kinetic temperatures of T{ k} ~ 25-55 K. With these physical parameters in conjunction with our previously observed 492 GHz [CI] line map, we will discuss a thermal chemical photodissociation model of gas clouds around star forming sites in NGC 6334. This research was supported by the National Science Foundation under a cooperative agreement with the Center for Astrophysical Research in Antarctica (CARA), grant NSF OPP 89-20223. CARA is a National Science Foundation Science and Technology Center.

  17. New RO TFC Membranes by Interfacial Polymerization in n-Dodecane with Various co-Solvents.

    PubMed

    Al-Hobaib, Abdullah Sulaiman; Al-Suhybani, Mohammed Sulaiman; Al-Sheetan, Khalid Mohammed; Mousa, Hasan; Shaik, Mohammed Rafi

    2016-04-29

    The objective of this research is to prepare and characterize a new and highly efficient polyamide TFC RO membrane by interfacial polymerization in dodecane solvent mixed with co-solvents. Three co-solvents were tested namely; acetone, ethyl acetate, and diethyl ether of concentration of 0.5, 1, 2, 3, and 5 wt %. The modified membranes were characterized by SEM, EDX, AFM and contact angle techniques. The results showed that addition of co-solvent results in a decrease in the roughness, pore size and thickness of the produced membranes. However, as the concentration of the co-solvent increases the pore size of the membranes gets larger. Among the three co-solvents tested, acetone was found to result in membranes with the largest pore size and contact angle followed by diethyl ether then ethyl acetate. Measured contact angle increases as the concentration of the co-solvent increases reaching a constant value except for ethyl acetate where it was found to drop. Investigating flux and salt rejection by the formulated membranes showed that higher flux was attained when acetone was used as a co-solvent followed by diethyl ether then ethyl acetate. However, the highest salt rejection was achieved with diethyl ether.

  18. The ro-vibrational `conveyor belt' for all-optical lasing during laser filamentation in Nitrogen

    NASA Astrophysics Data System (ADS)

    Ivanov, Misha; Richter, Maria; Morales, Felipe; Smirnova, Olga

    2016-05-01

    Inducing and controlling lasing in the open air is an intriguing challenge. Recent experiments on laser filamentation in the air have demonstrated generation of population inversion and lasing on the 391 nm line in the nitrogen ion, which corresponds to the transition between its second excited B2Σu+ and the ground X2Σg+ electronic states. Importantly, lasing at this transition appears to be a very general effect, arising during filamentation of virtually any incident radiation, from visible to mid-infrared. We analyze the possible mechanisms that can be responsible for the generation of the population inversion between the B2Σu+ and X2Σg+ states of N2+,focusing on the interplay between tunnel ionization of neutral nitrogen to different electronic states, ultrafast laser driven electronic excitations in the ion, molecular vibrations, laser induced alignment and rotations. We show how the strong laser field creates a ro-vibrational `conveyor belt' carrying the population away from the ground electronic state X2Σg+ and enabling population inversion in B2Σu+ . We show that this mechanism is robust with respect to the incident laser wavelength, and analyze its optimization with respect to the fundamental wavelength and pulse duration.

  19. Thermal maturity patterns in New York State using CAI and %Ro

    USGS Publications Warehouse

    Weary, D.J.; Ryder, R.T.; Nyahay, R.E.

    2001-01-01

    New conodont alteration index (CAI) and vitrinite reflectance (%Ro) data collected from drill holes in the Appalachian basin of New York State allow refinement of thermal maturity maps for Ordovician and Devonian rocks. CAI isotherms on the new maps show a pattern that approximates that published by Harris et al. (1978) in eastern and western New York, but it differs in central New York, where the isotherms are shifted markedly westward by more than 100 km and are more tightly grouped. This close grouping of isograds reflects a steeper thermal gradient than previously noted by Harris et al. (1978) and agrees closely with the abrupt west-to-east increase in thermal maturity across New York noted by Johnsson (1986). These data show, in concordance with previous studies, that thermal maturity levels in these rocks are higher than can be explained by simple burial heating beneath the present thickness of overburden. The Ordovician and Devonian rocks of the Appalachian Basin in New York must have been buried by very thick post-Devonian sediments (4-6 km suggested by Sarwar and Friedman 1995) or were exposed to a higher-than-normal geothermal flux caused by crustal extension, or a combination of the two.

  20. Synergies of CoRoT asteroseismology and APOGEE spectroscopy -- Applications to Galactic Archaeology

    NASA Astrophysics Data System (ADS)

    Anders, Friedrich; Chiappini, Cristina; Silva Rodrigues, Thaíse; Miglio, Andrea; Montalbàn, Josefina; Mosser, Benoit; Girardi, Leo; Valentini, Marica; Steinmetz, Matthias

    2015-08-01

    We present the first coherent dataset of 678 solar-like oscillating CoRoT red-giant stars located in two fields of the Galactic disc which have been followed up spectroscopically by the Apache Point Observatory Galactic Evolution Experiment (APOGEE).For the first time in a homogeneous analysis, ages and chemical abundance patterns of field stars have been measured over a largeradial range of the Milky Way's disc (4.5 kpc