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Sample records for juan del ro

  1. Eighth annual Juan del Regato lecture. Chemical modifiers of radiosensitivity--theory and reality: a review

    SciTech Connect

    Fowler, J.F.

    1985-04-01

    In this review the poor clinical gains from hyperbaric oxygen (HBO) and misonidazole (MISO) are discussed critically. The biggest factor reducing clinical gains is almost certainly reoxygenation. Other possible reasons include vasoconstrictive self-limitation of HBO and neurotoxicity of MISO, so that the radiosensitization of any hypoxic cells in human tumors was not adequate. Nevertheless, there have been some positive clinical results, so that hypoxic cells can sometimes be a problem in some tumors, especially those of the head and neck, even after multiple fraction radiotherapy. While hypoxic cell radioresistance is obviously only one form of radioresistance it is a large factor of resistance when hypoxic cells are present. Current developments are briefly reviewed: the new clinical sensitizers Ro-03-8799 and SR-2508 which should be 3 to 10 times more efficient than MISO if viable hypoxic cells are present; and methods of measuring which human tumors might have significant numbers of hypoxic viable cells. 77 references.

  2. Paleogene and Neogene magmatism in the Valle del Cura region: New perspective on the evolution of the Pampean flat slab, San Juan province, Argentina

    NASA Astrophysics Data System (ADS)

    Litvak, Vanesa D.; Poma, Stella; Kay, Suzanne Mahlburg

    2007-09-01

    The Valle del Cura region is characterized by a thick volcanic and volcaniclastic sequence that records the Tertiary arc and backarc magmatic evolution of the Argentine Main Cordillera over the modern Pampean flatslab at 29.5-30°S. During the Eocene, a retroarc basin developed, represented by the Valle del Cura Formation synorogenic volcanosedimentary sequence, which includes rhyolites and dacitic tuffs. These silicic volcanic rocks have weak arc chemical signatures and high lithophile element concentrations and are isotopically enriched relative to the late Oligocene-early Miocene volcanic rocks that followed them. Their chemical characteristics fit with eruption through a thin crust. The Valle de Cura Formation was followed by the Oligocene-early Miocene Doña Ana Group volcanic sequence, which erupted at and near the arc front west of the border with Chile. The Doña Ana Group volcanic rocks have calc-alkaline chemical characteristics consistent with parental magmas forming in a mantle wedge and erupting through a normal thickness crust (35 km). Subsequent shallowing of the downgoing Nazca plate caused the volcanic front to migrate eastward. The volcanic sequences of the middle Miocene Cerro de las Tórtolas Formation erupted at this new arc front, essentially at the Argentine border. Two stages are recognized: an older one (16-14 Ma) in which magmas appear to have erupted through a normal thickness crust (30-35 km) and a younger one (13-10 Ma) in which the steeper REE pattern suggests the magmas last equilibrated with higher pressure residual mineral assemblages in a thicker crust. Isotopic ratios in the younger group are consistent with an increase in original crustal components and crust introduced into the mantle source by forearc subduction erosion. A peak in forearc subduction erosion near 12-10 Ma is consistent with when the main part of the Juan Fernandez Ridge began to subduct beneath the region. In addition to late Miocene Tambo Formation dacitic

  3. [Patient satisfaction when seen in the Emergency room of San Juan de Dios del Aljarafe Hospital (Spain)].

    PubMed

    Ruiz Romero, V; Fajardo Molina, J; García-Garmendia, J L; Cruz Villalón, F; Rodríguez Ortiz, R; Varela Ruiz, F J

    2011-01-01

    To find out the level of satisfaction of patients seen in the Emergency room of the of San Juan de Dios Hospital, Aljarafe; to identify the determining factors and to define the areas that need improvement and reinforcement in order to improve the quality of care. A telephone survey was carried out between July and September, 2008, containing 44 questions, 2 with a closed response, 3 with yes/no answers and the remaining questions scored based on a Likert type scale of 1 (most negative answer) to 5 (most positive answer). Observations were also recorded. Overall satisfaction was 84.7%: 82% would recommend this Emergency room, and 59.6% considered it better than others. The aspects to be emphasised are: respect (97.6%), cleanliness (97.1%) and intimacy (94.6%). Following these were: the doctor's disposition to listen (93.1%); the preparation of the professionals (from 92.3% for the administration professionals to 88.6% for auxiliary nurses); kindness (from 91.8% for doctors to 89.9% for nurses); and the ease of getting orientated (90%). The information given was evaluated positively by 70.3%, and 87% acknowledged understanding this information. However, 52.4% of patients were satisfied with the information given during triage related to the stay in the emergency room, and, 22.3% as regards the probable waiting period. The satisfaction with the waiting between triage and first medical consultation was higher in the one-two-triage patients and was lower in the four-triage ones; in the waiting between first medical consultation and the discharge, the one-triage patients were more satisfied than the rest. Nevertheless, there were no statistically significant differences with satisfaction with the waiting until the triage. The percentages of satisfaction was greater than 80% in 23 of the 34 items, with certain aspects having a satisfaction rate over 90%: respect, cleanliness, the doctor's predisposition to listen, qualification and kindness of the personnel. On the

  4. 46 CFR 111.105-40 - Additional requirements for RO/RO vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RO/RO vessels. (a) Each RO/RO vessel must meet ABS Steel Vessel Rules (incorporated by reference; see... 1 hazardous location. (c) Where the ventilation requirement of ABS Steel Vessel Rules section...

  5. CoRoTlog

    NASA Astrophysics Data System (ADS)

    Plasson, Ph.

    2006-11-01

    LESIA, in close cooperation with CNES, DLR and IWF, is responsible for the tests and validation of the CoRoT instrument digital process unit which is made up of the BEX and DPU assembly. The main part of the work has consisted in validating the DPU software and in testing the BEX/DPU coupling. This work took more than two years due to the central role of the software tested and its technical complexity. The first task, in the validation process, was to carry out the acceptance tests of the DPU software. These tests consisted in checking each of the 325 requirements identified in the URD (User Requirements Document) and were played in a configuration using the DPU coupled to a BEX simulator. During the acceptance tests, all the transversal functionalities of the DPU software, like the TC/TM management, the state machine management, the BEX driving, the system monitoring or the maintenance functionalities were checked in depth. The functionalities associated with the seismology and exoplanetology processing, like the loading of window and mask descriptors or the configuration of the service execution parameters, were also exhaustively tested. After having validated the DPU software against the user requirements using a BEX simulator, the following step consisted in coupling the DPU and the BEX in order to check that the formed unit worked correctly and met the performance requirements. These tests were conducted in two phases: the first one was devoted to the functional aspects and the tests of interface, the second one to the performance aspects. The performance tests were based on the use of the DPU software scientific services and on the use of full images representative of a realistic sky as inputs. These tests were also based on the use of a reference set of windows and parameters, which was provided by the scientific team and was representative, in terms of load and complexity, of the one that could be used during the observation mode of the CoRoT instrument

  6. Remembering Juan Navia.

    PubMed

    Dasanayake, A P; Li, Y; Maetz, H M; Vermund, S H

    2013-10-01

    Juan Navia died on September 4, 2010. Those who knew him as the director of the University of Alabama's John J. Sparkman Center for International Public Health Education and later the dean of UAB School of Public Health watched him train and shape the next generation of global public health leaders with a kind heart and a firm, but gentle, hand. On this third anniversary of Professor Navia's passing, in response to an invitation from the Journal of Dental Research to write an essay on an educator who influenced the professional trajectories of many people, we have put together an account of some of his contributions and attributes to highlight this remarkable leader's accomplishments in and impact on dental public health and global nutrition.

  7. Conversation with Juan Carlos Negrete.

    PubMed

    Negrete, Juan Carlos

    2013-08-01

    Juan Carlos Negrete is Emeritus Professor of Psychiatry, McGill University; Founding Director, Addictions Unit, Montreal General Hospital; former President, Canadian Society of Addiction Medicine; and former WHO/PAHO Consultant on Alcoholism, Drug Addiction and Mental Health.

  8. Source rock maturation, San Juan sag

    SciTech Connect

    Gries, R.R.; Clayton, J.L.

    1989-09-01

    Kinetic modeling for thermal histories was simulated for seven wells in the San Juan sag honoring measured geochemical data. Wells in the area of Del Norte field (Sec. 9, T40N, R5E), where minor production has been established from an igneous sill reservoir, show that the Mancos Shale source rocks are in the mature oil generation window as a combined result of high regional heat flow and burial by approximately 2,700 m of Oligocene volcanic rocks. Maturation was relatively recent for this area and insignificant during Laramide subsidence. In the vicinity of Gramps field (Sec. 24, T33N, R2E) on the southwest flank of the San Juan sag, these same source rocks are exposed due to erosion of the volcanic cover but appear to have undergone a similar maturation history. At the north and south margins of the sag, two wells (Champlin 34A-13, Sec. 13, T35N, R4.5E; and Champlin 24A-1, Sec. 1, T44N, R5E) were analyzed and revealed that although the regional heat flow was probably similar to other wells, the depth of burial was insufficient to cause maturation (except where intruded by thick igneous sills that caused localized maturation). The Meridian Oil 23-17 South Fork well (Sec. 17, T39N, R4E) was drilled in a deeper part of the San Juan sag, and source rocks were intruded by numerous igneous sills creating a complex maturation history that includes overmature rocks in the lowermost Mancos Shale, possible CO{sub 2} generation from the calcareous Niobrara Member of the Mancos Shale, and mature source rocks in the upper Mancos Shale.

  9. 46 CFR 111.105-40 - Additional requirements for RO/RO vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-40 Additional requirements for RO/RO vessels. (a) Each RO/RO vessel must meet ABS Steel Vessel Rules (incorporated by reference; see... 1 hazardous location. (c) Where the ventilation requirement of ABS Steel Vessel Rules section 4-8-4...

  10. Counseling According to don Juan

    ERIC Educational Resources Information Center

    Pulvino, Charles J.; Lee, James L.

    1975-01-01

    This article specifies a number of precepts put forth by don Juan, a Yaqui Indian sorcerer. It also outlines the consequences of each precept for counselors. The intent is to facilitate the emergence of a new reality for counseling and other helping professions. (Author/BW)

  11. RoKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose.

    PubMed

    Randoux, Marie; Davière, Jean-Michel; Jeauffre, Julien; Thouroude, Tatiana; Pierre, Sandrine; Toualbia, Youness; Perrotte, Justine; Reynoird, Jean-Paul; Jammes, Marie-José; Hibrand-Saint Oyant, Laurence; Foucher, Fabrice

    2014-04-01

    FT/TFL1 family members have been known to be involved in the development and flowering in plants. In rose, RoKSN, a TFL1 homologue, is a key regulator of flowering, whose absence causes continuous flowering. Our objectives are to functionally validate RoKSN and to explore its mode of action in rose. We complemented Arabidopsis tfl1 mutants and ectopically expressed RoKSN in a continuous-flowering (CF) rose. Using different protein interaction techniques, we studied RoKSN interactions with RoFD and RoFT and possible competition. In Arabidopsis, RoKSN complemented the tfl1 mutant by rescuing late flowering and indeterminate growth. In CF roses, the ectopic expression of RoKSN led to the absence of flowering. Different branching patterns were observed and some transgenic plants had an increased number of leaflets per leaf. In these transgenic roses, floral activator transcripts decreased. Furthermore, RoKSN was able to interact both with RoFD and the floral activator, RoFT. Protein interaction experiments revealed that RoKSN and RoFT could compete with RoFD for repression and activation of blooming, respectively. We conclude that RoKSN is a floral repressor and is also involved in the vegetative development of rose. RoKSN forms a complex with RoFD and could compete with RoFT for repression of flowering. © 2013 INRA. New Phytologist © 2013 New Phytologist Trust.

  12. 75 FR 51098 - Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, Island, San Juan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... Fish and Wildlife Service Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, Island, San Juan, Skagit, and Whatcom Counties, WA AGENCY: Fish and Wildlife Service, Interior. ACTION... plan (WSP), and environmental assessment (EA) for Protection Island and San Juan Islands National...

  13. Characterisation of RO fouling in an integrated MBR/RO system for wastewater reuse.

    PubMed

    Moreno, J; Monclús, H; Stefani, M; Cortada, E; Aumatell, J; Adroer, N; De Lamo-Castellví, S; Comas, J

    2013-01-01

    Membrane filtration has gradually gained acceptance as the preferred pre-treatment for reverse osmosis (RO). In this paper, an integrated membrane bioreactor (MBR)/RO system for wastewater reuse treating real sewage water has been evaluated and the RO fouling has been characterised. The MBR achieved low values of organic matter, total nitrogen, PO(4)(3-), total organic carbon, turbidity and conductivity. Filtration with two different RO commercial membranes was performed after the MBR pre-treatment and the same average fouling rate (0.08 bar day(-1)) was noted. These results gained from the characterisation of the high quality MBR/RO permeate show its potential for water reuse. Inorganic precipitation appears to be the predominant form of fouling in the RO membranes. Calcium phosphate and alumino-silicates were identified by a scanning electron microscope combined with an energy dispersive X-ray and polysaccharides, amide and aliphatic structures were detected with attenuated total reflection infrared microspectroscopy.

  14. AST/RO: Submillimeter Astronomy

    NASA Astrophysics Data System (ADS)

    Lane, Adair P.

    1998-05-01

    Submillimeter astronomy can only be pursued from extremely cold and dry sites, where the atmosphere contains a minimal amount of precipitable water. Water vapor measurements at the South Pole, in conjunction with submillimeter skydip measurements, show that the Antarctic Plateau provides the best submillimeter observing conditions on Earth. The 1.7-m diameter telescope of the Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) has been exploiting these conditions for the past 3 years to study atomic carbon (CI) and J=4-3 CO emission in a broad range of physical environments in the Milky Way and Large Magellanic Cloud. We have found from samples of [CI] emission throughout the plane of the Milky Way that [CI] arises primarily in the photodissociated skins of molecular clouds. A detection of the 492 GHz [CI] line in absorption allows the derivation of lower limits for the [CI] column density in cold foreground material in the Galactic disk. Comparison of the absorption data with the low-resolution COBE FIRAS [CI] emission line survey in the Galactic plane indicates that a substantial fraction of the atomic carbon in the interstellar medium has very low excitation and thus may be difficult to detect in emission. Observations of [CI] in the LMC indicate that photodissociation regions are enhanced in this low metallicity system. This research was supported in part by the National Science Foundation under a cooperative agreement with the Center for Astrophysical Research in Antarctica (CARA), grant number NSF OPP 89-20223. CARA is a National Science Foundation Science and Technology Center.

  15. Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies.

    PubMed

    Strandberg, L; Salomonsson, S; Bremme, K; Sonesson, S- E; Wahren-Herlenius, M

    2006-01-01

    Congenital heart block occurs in fetuses of Ro/SSA and La/SSB positive women. To investigate the stability of maternal autoantibody levels during pregnancy, we followed Ro52, Ro60 and La autoantibody IgG level variation and Ro52 subclass profiles longitudinally in selected congenital heart block risk pregnancies. Serum samples were obtained from 12 Ro/La positive women diagnosed with a systemic rheumatic disease and followed on average 60 months (range two to 84) which included 13 pregnancies. Seven children were affected by neonatal lupus, whereof four developed complete congenital heart block. Serum was also collected from the babies at birth. Ro52, Ro60 and La IgG as well as subclass antibodies were analysed by ELISA using recombinant antigens. Six Ro/La negative rheumatic patients were included as controls for antibody levels during pregnancy. Ro52, Ro60 and La IgG levels decreased progressively from early to late pregnancy, significantly for Ro52 and Ro60 (P < 0.01). No peaks or persistent elevation of antibody levels were noted in any of the CHB risk pregnancies. Ro52 IgG1 antibody levels were significantly higher than IgG2 (P < 0.01), IgG3 (P < 0.01) and IgG4 (P < 0.05) levels in the mothers during pregnancy. Ro52 IgG1 and IgG4 levels decreased significantly from early to late pregnancy (P = 0.02), while levels of IgG2 and IgG3 were low and the decrease was not significant. All IgG subclasses were transferred to the children. We conclude that maternal levels of Ro52, Ro60 and La autoantibodies tended rather to decrease than to increase during pregnancy.

  16. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of the...

  17. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of the...

  18. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... following area: (1) The waters around Liquefied Petroleum Gas ships entering San Juan Harbor in an area one... referenced use datum: NAD 83. (2) The waters around Liquefied Petroleum Gas ships departing San Juan Harbor... Petroleum Gas vessels via a marine broadcast Notice to Mariners. (5) Should the actual time of entry of the...

  19. Ro(SS-A) and anti-Ro(SS-A): an update.

    PubMed

    Sibilia, J

    1998-01-01

    Anti-Ro/SSA antibodies are the antinuclear antibodies most commonly found in everyday clinical practice and are closely associated with Sjögren's syndrome, systemic lupus erythematosus and neonatal lupus. They play a pathogenic role in a variety of clinical manifestations, including skin lesions and neonatal lupus heart block. Autoantibodies to Ro(SS-A) recognize a ribonucleoprotein complex composed of small single-stranded RNAs (hYRNAs) and of one or more peptides. Four molecular forms of this complex have been differentiated based on the nature of the peptide: a lymphocyte and an erythrocyte Ro with a 60 kDa peptide, a lymphocyte Ro with a 52 kDa peptide and an erythrocyte Ro with a 54 kDa peptide. The Ro complex is found in most tissues and cells (erythrocytes, platelets), with differences in structure and quantity across tissues, species and embryonic development stages. Although its function remains unknown, its ability to bind nucleic acids and the fact that it shares homologies with gene regulation proteins suggest that it may participate in RNA transcription processes. A number of environmental factors (exposure to ultraviolet radiation, viral infections) may cause translocation of the Ro complex to nucleocytoplasmic and membrane sites where it is not normally found, thereby leading to the development of autoimmunity. The structure of the Ro(SS-A)-hYRNA complex and the development of autoimmunity are currently the focus of active research efforts that can be expected to improve our understanding of the clinical manifestations directly related to anti-Ro(SS-A) antibodies.

  20. Cytoplasmic relocation of Daxx induced by Ro52 and FLASH

    PubMed Central

    Tanaka, Makoto; Kamitani, Tetsu

    2010-01-01

    The RING-finger protein Ro52/TRIM21 is known to be an autoantigen and is recognized by anti-Ro/SSA antibodies, which are commonly found in patients with Sjögren's syndrome and systemic lupus erythematosus. We recently showed that Ro52 is an E3 ubiquitin ligase and localizes to cytoplasmic bodies that are highly motile along the microtubule network. To expand our knowledge of Ro52, we searched partners co-operating with Ro52. We performed a yeast two-hybrid screening of a human brain cDNA library with Ro52 as bait. This screening identified several genes encoding Ro52-interacting proteins, including the apoptosis-related proteins, Daxx and FLASH. Further yeast two-hybrid assays revealed that Daxx binds to the B30.2 domain of Ro52 and that FLASH binds to coiled-coil domains of Ro52 through its death-effector domain-recruiting domain. These results suggest that Ro52, Daxx, and FLASH form heteromeric protein complexes. Indeed, this was supported by results of immunoprecipitation experiments in which we found that Daxx is co-immunoprecipitated with Ro52 in the presence of overexpressed FLASH. Importantly, our fluorescence microscopy revealed that, although Daxx is predominantly located in the nucleus, overexpression of both Ro52 and FLASH leads to relocation of Daxx into the cytoplasm. Thus, Ro52 seems to co-operate with FLASH to induce cytoplasmic localization of Daxx in cells. PMID:20697732

  1. Transiting exoplanets from the CoRoT space mission. VIII. CoRoT-7b: the first super-Earth with measured radius

    NASA Astrophysics Data System (ADS)

    Léger, A.; Rouan, D.; Schneider, J.; Barge, P.; Fridlund, M.; Samuel, B.; Ollivier, M.; Guenther, E.; Deleuil, M.; Deeg, H. J.; Auvergne, M.; Alonso, R.; Aigrain, S.; Alapini, A.; Almenara, J. M.; Baglin, A.; Barbieri, M.; Bruntt, H.; Bordé, P.; Bouchy, F.; Cabrera, J.; Catala, C.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Foing, B.; Fressin, F.; Gandolfi, D.; Gillon, M.; Gondoin, Ph.; Grasset, O.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Renner, S.; Samadi, R.; Shporer, A.; Sotin, Ch.; Tingley, B.; Wuchterl, G.; Adda, M.; Agogu, P.; Appourchaux, T.; Ballans, H.; Baron, P.; Beaufort, T.; Bellenger, R.; Berlin, R.; Bernardi, P.; Blouin, D.; Baudin, F.; Bodin, P.; Boisnard, L.; Boit, L.; Bonneau, F.; Borzeix, S.; Briet, R.; Buey, J.-T.; Butler, B.; Cailleau, D.; Cautain, R.; Chabaud, P.-Y.; Chaintreuil, S.; Chiavassa, F.; Costes, V.; Cuna Parrho, V.; de Oliveira Fialho, F.; Decaudin, M.; Defise, J.-M.; Djalal, S.; Epstein, G.; Exil, G.-E.; Fauré, C.; Fenouillet, T.; Gaboriaud, A.; Gallic, A.; Gamet, P.; Gavalda, P.; Grolleau, E.; Gruneisen, R.; Gueguen, L.; Guis, V.; Guivarc'h, V.; Guterman, P.; Hallouard, D.; Hasiba, J.; Heuripeau, F.; Huntzinger, G.; Hustaix, H.; Imad, C.; Imbert, C.; Johlander, B.; Jouret, M.; Journoud, P.; Karioty, F.; Kerjean, L.; Lafaille, V.; Lafond, L.; Lam-Trong, T.; Landiech, P.; Lapeyrere, V.; Larqué, T.; Laudet, P.; Lautier, N.; Lecann, H.; Lefevre, L.; Leruyet, B.; Levacher, P.; Magnan, A.; Mazy, E.; Mertens, F.; Mesnager, J.-M.; Meunier, J.-C.; Michel, J.-P.; Monjoin, W.; Naudet, D.; Nguyen-Kim, K.; Orcesi, J.-L.; Ottacher, H.; Perez, R.; Peter, G.; Plasson, P.; Plesseria, J.-Y.; Pontet, B.; Pradines, A.; Quentin, C.; Reynaud, J.-L.; Rolland, G.; Rollenhagen, F.; Romagnan, R.; Russ, N.; Schmidt, R.; Schwartz, N.; Sebbag, I.; Sedes, G.; Smit, H.; Steller, M. B.; Sunter, W.; Surace, C.; Tello, M.; Tiphène, D.; Toulouse, P.; Ulmer, B.; Vandermarcq, O.; Vergnault, E.; Vuillemin, A.; Zanatta, P.

    2009-10-01

    December 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. First CoRoT data are available to the public from the CoRoT archive: http://idoc-corot.ias.u-psud.fr. The complementary observations were obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by NRC in Canada, INSU-CNRS in France, and the University of Hawaii; ESO Telescopes at the La Silla and Paranal Observatories under programme ID 081.C-0413(C), DDT 282.C-5015; the IAC80 telescope operated by the Instituto de Astrofísica de Tenerife at the Observatorio del Teide; the Isaac Newton Telescope (INT), operated on the island of La Palma by the Isaac Newton group in the Spanish Observatorio del Roque de Los Muchachos of the Instituto de Astrofisica de Canarias; and at the Anglo-Australian Telescope that have been funded by the Optical Infrared Coordination network (OPTICON), a major international collaboration supported by the Research Infrastructures Programme of the European Commissions Sixth Framework Programme; Radial-velocity observations were obtained with the SOPHIE spectrograph at the 1.93m telescope of Observatoire de Haute Provence, France.

  2. 76 FR 40876 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... Sonoran Meeting Rooms. Written comments should be sent to Attn: San Juan National Forest RAC, 15 Burnett...

  3. 76 FR 12692 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... comments should be sent to Attn: San Juan National Forest RAC, 15 Burnett Court, Durango, CO 81301...

  4. 75 FR 48306 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... comments should be sent to Attn: San Juan National Forest RAC, 15 Burnett Court, Durango, CO 81301...

  5. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  6. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  7. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  8. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Strait of Juan de Fuca. 80.1385... NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of the Strait of Juan de Fuca....

  9. AstRoMap European Astrobiology Roadmap

    PubMed Central

    Horneck, Gerda; Westall, Frances; Grenfell, John Lee; Martin, William F.; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R.; Rettberg, Petra; Capria, Maria Teresa

    2016-01-01

    Abstract The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems• Research Topic 2: Origins of Organic Compounds in Space• Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life• Research Topic 4: Life and Habitability• Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system. Key Words: Astrobiology roadmap—Europe—Origin and evolution of life—Habitability—Life detection—Life in extreme environments. Astrobiology 16, 201–243. PMID:27003862

  10. AstRoMap European Astrobiology Roadmap.

    PubMed

    Horneck, Gerda; Walter, Nicolas; Westall, Frances; Grenfell, John Lee; Martin, William F; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R; Rettberg, Petra; Capria, Maria Teresa

    2016-03-01

    The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems • Research Topic 2: Origins of Organic Compounds in Space • Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life • Research Topic 4: Life and Habitability • Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system.

  11. Juan Carlos D'Olivo: A portrait

    NASA Astrophysics Data System (ADS)

    Aguilar-Arévalo, Alexis A.

    2013-06-01

    This report attempts to give a brief bibliographical sketch of the academic life of Juan Carlos D'Olivo, researcher and teacher at the Instituto de Ciencias Nucleares of UNAM, devoted to advancing the fields of High Energy Physics and Astroparticle Physics in Mexico and Latin America.

  12. Transiting exoplanets from the CoRoT space mission. XXVII. CoRoT-28b, a planet orbiting an evolved star, and CoRoT-29b, a planet showing an asymmetric transit

    NASA Astrophysics Data System (ADS)

    Cabrera, J.; Csizmadia, Sz.; Montagnier, G.; Fridlund, M.; Ammler-von Eiff, M.; Chaintreuil, S.; Damiani, C.; Deleuil, M.; Ferraz-Mello, S.; Ferrigno, A.; Gandolfi, D.; Guillot, T.; Guenther, E. W.; Hatzes, A.; Hébrard, G.; Klagyivik, P.; Parviainen, H.; Pasternacki, Th.; Pätzold, M.; Sebastian, D.; Tadeu dos Santos, M.; Wuchterl, G.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Armstrong, J. D.; Auvergne, M.; Baglin, A.; Barge, P.; Barros, S. C. C.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carpano, S.; Chaffey, C.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Grziwa, S.; Korth, J.; Lammer, H.; Lindsay, C.; Mazeh, T.; Moutou, C.; Ofir, A.; Ollivier, M.; Pallé, E.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.

    2015-07-01

    Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims: We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods: We used the transit light curve to characterize the planetary parameters relative to the stellar parameters. The analysis of HARPS spectra established the planetary nature of the detections, providing their masses. Further photometric and spectroscopic ground-based observations provided stellar parameters (log g, Teff, v sin i) to characterize the host stars. Our model takes the geometry of the transit to constrain the stellar density into account, which when linked to stellar evolutionary models, determines the bulk parameters of the star. Because of the asymmetric shape of the light curve of one of the planets, we had to include the possibility in our model that the stellar surface was not strictly spherical. Results: We present the planetary parameters of CoRoT-28b, a Jupiter-sized planet (mass 0.484 ± 0.087 MJup; radius 0.955 ± 0.066 RJup) orbiting an evolved star with an orbital period of 5.208 51 ± 0.000 38 days, and CoRoT-29b, another Jupiter-sized planet (mass 0.85 ± 0.20 MJup; radius 0.90 ± 0.16 RJup) orbiting an oblate star with an orbital period of 2.850 570 ± 0.000 006 days. The reason behind the asymmetry of the transit shape is not understood at this point. Conclusions: These two new planetary systems have very interesting properties and deserve further study, particularly in the case of the star CoRoT-29. The CoRoT space mission, launched on December 27th 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain. Based on observations obtained with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland

  13. Anti-ENA profiles related with anti-SS-A/Ro. The detection of Ro52 and Ro60 according to the presence of SS-B/La, and ANA pattern and titer.

    PubMed

    González, D Almeida; Rodríguez, C Casañas; Armas, L Magdalena; Varela, A Roces; Rodríguez, I Marcelino; Duarte, M Troche; de León, A Cabrera

    2014-09-01

    Anti-Ro52 (Ro52) and anti-Ro60 (Ro60) antibodies are associated with different clinical entities. We investigated their relationship with the presence of anti-SS-B/La (SSB) antibody, the pattern and titer of antinuclear antibody (ANA), and the variations in antibody profiles related with anti-SS-A/Ro (SSA) positivity. Our aim was to develop a strategy to increase the efficiency of anti-extractable nuclear antigen (ENA) determinations. Statistical analyses were based on the Chi-squared test for categorical variables, the Mann-Whitney U test to compare profiles, and the odds ratio (OR) and 95% confidence interval (95% CI) to estimate the risk of variability. We analyzed 800 SSA-positive samples with Ro52 or Ro60 reactivity. The most frequent profiles were Ro52+Ro60+SSB (n=349, 43.6%); Ro52+Ro60 (n=126, 15.8%); Ro52 (n=121, 15.1%) and Ro60 (n=71, 8.9%). In samples positive only for SSA and an ANA titer ≤1:640, the most likely profile was positivity for either Ro52 or Ro60, whereas when the ANA titer was >1:640, positivity for both Ro52 and Ro60 simultaneously was more likely (p<0.001). In samples positive for both SSA and SSB, the most likely profile was Ro52+Ro60+SSB regardless of the ANA titer (p=0.001). When only SSA was positive and the ANA staining pattern was nucleolar, centromeric or cytoplasmic, Ro52 positivity was most likely (p<0.001). When both SSA and SSB were positive, both Ro52 and Ro60 were likely to be positive regardless of the ANA staining pattern. In 28.7% of the patients the profile was variable. Variability was significantly greater in those with the SSA profile (23/67) than with the SSA+SSB profile (15/105; OR=1.9, 95% CI=1.1-3.3; p=0.025), and the difference in variability was greatest between the Ro52+Ro60 profile (8/23) and the Ro52+Ro60+SSB profile (8/68; OR=4.2, 95% CI=1.9-9.5; p<0.001). We conclude that to increase efficiency in the immunology laboratory, positivity for Ro52 and Ro60 individually or simultaneously can be deduced from SSB

  14. Don Juan and the vision of Vision.

    PubMed

    Smith, C U

    1981-01-01

    Castaneda's well-known sequence of Don Juan books is used as a paradigmatic example of the relativist position. Central to Don Juan's teaching is the problem of perception: the main task, he constantly reiterates, is simply to 'see', to recognise that the commonsense world we customarily perceive is nothing more than a cultural construct. To combat this thoroughgoing relativism a case study is taken from the early history of visual science. In classical antiquity several fundamentally different 'views' (to use Don Juan's term) of how we see contended for approval. It was only at the beginning of the seventeenth century that the 'modern' interpretation was selected. This interpretation was selected, ultimately, because it 'worked'. Reference is made to both Wittgenstein and Marx to support this appeal to praxis. It is argued that through an intricate, complex, and ill-understood process of popularisation our self-image is ultimately grounded in the theories of natural science; and these, in turn, are ultimately grounded in our action in the world of things.

  15. Exoplanet discoveries with the CoRoT space observatory

    NASA Astrophysics Data System (ADS)

    Lammer, H.; Dvorak, R.; Deleuil, M.; Barge, P.; Deeg, H. J.; Moutou, C.; Erikson, A.; Csizmadia, Sz.; Tingley, B.; Bruntt, H.; Havel, M.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barbieri, M.; Benz, W.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cabrera, J.; Carone, L.; Carpano, S.; Ciardi, D.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Gondoin, P.; Guenther, E.; Guillot, T.; den Hartog, R.; Hasiba, J.; Hatzes, A.; Hidas, M.; Hébrard, G.; Jorda, L.; Kabath, P.; Léger, A.; Lister, T.; Llebaria, A.; Lovis, C.; Mayor, M.; Mazeh, T.; Mura, A.; Ollivier, M.; Ottacher, H.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rabus, M.; Rauer, H.; Rouan, D.; Samuel, B.; Schneider, J.; Shporer, A.; Stecklum, B.; Steller, M.; Street, R.; Udry, S.; Weingrill, J.; Wuchterl, G.

    2010-12-01

    The CoRoT space observatory is a project which is led by the French space agency CNES and leading space research institutes in Austria, Brazil, Belgium, Germany and Spain and also the European Space Agency ESA. CoRoT observed since its launch in December 27, 2006 about 100 000 stars for the exoplanet channel, during 150 days uninterrupted high-precision photometry. Since the The CoRoT-team has several exoplanet candidates which are currently analyzed under its study, we report here the discoveries of nine exoplanets which were observed by CoRoT. Discovered exoplanets such as CoRoT-3b populate the brown dwarf desert and close the gap of measured physical properties between usual gas giants and very low mass stars. CoRoT discoveries extended the known range of planet masses down to about 4.8 Earth-masses (CoRoT-7b) and up to 21 Jupiter masses (CoRoT-3b), the radii to about 1.68 × 0.09 R Earth (CoRoT-7b) and up to the most inflated hot Jupiter with 1.49 × 0.09 R Earth found so far (CoRoT-1b), and the transiting exoplanet with the longest period of 95.274 days (CoRoT-9b). Giant exoplanets have been detected at low metallicity, rapidly rotating and active, spotted stars. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planethost-star-metallicity relation then the one found by radial-velocity search programs. Finally the properties of the CoRoT-7b prove that rocky planets with a density close to Earth exist outside the Solar System. Finally the detection of the secondary transit of CoRoT-1b at a sensitivity level of 10-5 and the very clear detection of the "super-Earth" CoRoT-7b at 3.5 × 10-4 relative flux are promising evidence that the space observatory is being able to detect even smaller exoplanets with the size of the Earth.

  16. RoMPS concept review automatic control of space robot

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Robot operated Material Processing in Space (RoMPS) experiment is being performed to explore the marriage of two emerging space commercialization technologies: materials processing in microgravity and robotics. This concept review presents engineering drawings and limited technical descriptions of the RoMPS programs' electrical and software systems.

  17. Cesáro partial sums of concave univalent functions

    NASA Astrophysics Data System (ADS)

    Aldawish, Ibtisam; Darus, Maslina

    2014-06-01

    In this article, we consider the Cesáro partial sums of certain concave univalent functions. We studied geometric properties of the Cesáro partial sums of certain concave univalent functions in the open unit disk. Examples are illustrated.

  18. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a...

  19. 29 CFR 1918.86 - Roll-on roll-off (Ro-Ro) operations (see also § 1918.2, Ro-Ro operations, and § 1918.25).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Ro-Ro operations, and § 1918.25). 9 (a) Traffic control system. An organized system of vehicular and pedestrian traffic control shall be established and maintained at each entrance/exit ramp and on ramps within... their cargo capacities and shall not be overloaded. (h) Cargo weights. Cargo to be handled via a...

  20. Recent standardization activities on radio on fiber (RoF)

    NASA Astrophysics Data System (ADS)

    Ogawa, Hiroyo; Kuri, Toshiaki; Kanno, Atsushi; Kawanishi, Tetsuya

    2013-12-01

    The Radio on Fiber (RoF) technologies are unique transmission means of radio analog signals through optical fiber cables. These technologies are currently discussed at international standard organizations such as ITU-T, IEC, APT and IEEE802. This invited paper summarizes RoF standardization activities at those standard organizations.

  1. An Introduction to the RoLI[TM

    ERIC Educational Resources Information Center

    Meyer, Jan H. F.

    2004-01-01

    The Reflections on Learning Inventory (RoLI) is an instrument designed to capture variation in students' engagement of learning--typically in a given disciplinary context or topic-specific 'episode'. Although the RoLI has been employed as a research instrument in a number of published studies on the modelling of student learning in higher…

  2. SyRoTek--Distance Teaching of Mobile Robotics

    ERIC Educational Resources Information Center

    Kulich, M.; Chudoba, J.; Kosnar, K.; Krajnik, T.; Faigl, J.; Preucil, L.

    2013-01-01

    E-learning is a modern and effective approach for training in various areas and at different levels of education. This paper gives an overview of SyRoTek, an e-learning platform for mobile robotics, artificial intelligence, control engineering, and related domains. SyRoTek provides remote access to a set of fully autonomous mobile robots placed in…

  3. SyRoTek--Distance Teaching of Mobile Robotics

    ERIC Educational Resources Information Center

    Kulich, M.; Chudoba, J.; Kosnar, K.; Krajnik, T.; Faigl, J.; Preucil, L.

    2013-01-01

    E-learning is a modern and effective approach for training in various areas and at different levels of education. This paper gives an overview of SyRoTek, an e-learning platform for mobile robotics, artificial intelligence, control engineering, and related domains. SyRoTek provides remote access to a set of fully autonomous mobile robots placed in…

  4. 9 years of existence of the site astronomy.ro

    NASA Astrophysics Data System (ADS)

    Haus, Marian

    2013-06-01

    The article represents a history of the Astronomical site: http://www.astronomy.ro and its forum http://www.astronomy.ro/forum/. To the actual moment about 1700 members - amateur astronomers from every where in Romania and outside - contribute to this site and forum. The main areas of interst are: Astronomical Instruments, Astrophotography, Eclipses, Solar Astronomy, Comets, Asteroids and Meteors, Optics.

  5. [Juan Valverde de Amusco c. 1525-1588 and his vocation for anatomy in the Hispano-Italian Renaissance].

    PubMed

    Hernández-Mansilla, José Miguel

    2015-01-01

    The XVIth century witnessed a glorious period in the progress of some of the basic medical sciences among which anatomy stands out. One of the well-known figures involved in the development of this subject was Juan Valverde de Amusco, a notable Spanish scientist. This research shows the most relevant data currently known on his life, sociocultural environment and his celebrated treaty on anatomy titled: "Historia de la composición del cuerpo humano". (History of the human body).

  6. Photometric variability of the Be star CoRoT-ID 102761769

    NASA Astrophysics Data System (ADS)

    Emilio, M.; Andrade, L.; Janot-Pacheco, E.; Baglin, A.; Gutiérrez-Soto, J.; Suárez, J. C.; de Batz, B.; Diago, P.; Fabregat, J.; Floquet, M.; Frémat, Y.; Huat, A. L.; Hubert, A. M.; Espinosa Lara, F.; Leroy, B.; Martayan, C.; Neiner, C.; Semaan, T.; Suso, J.

    2010-11-01

    Context. Classical Be stars are rapid rotators of spectral type late O to early A and luminosity class V-III, which exhibit Balmer emission lines and often a near infrared excess originating in an equatorially concentrated circumstellar envelope, both produced by sporadic mass ejection episodes. The causes of the abnormal mass loss (the so-called Be phenomenon) are as yet unknown. Aims: For the first time, we can now study in detail Be stars outside the Earth's atmosphere with sufficient temporal resolution. We investigate the variability of the Be Star CoRoT-ID 102761769 observed with the CoRoT satellite in the exoplanet field during the initial run. Methods: One low-resolution spectrum of the star was obtained with the INT telescope at the Observatorio del Roque de los Muchachos. A time series analysis was performed using both cleanest and singular spectrum analysis algorithms to the CoRoT light curve. To identify the pulsation modes of the observed frequencies, we computed a set of models representative of CoRoT-ID 102761769 by varying its main physical parameters inside the uncertainties discussed. Results: We found two close frequencies related to the star. They are 2.465 c d-1 (28.5 μHz) and 2.441 c d-1 (28.2 μHz). The precision to which those frequencies were found is 0.018 c d-1 (0.2 μHz). The projected stellar rotation was estimated to be 120 km s-1 from the Fourier transform of spectral lines. If CoRoT-ID 102761769 is a typical Galactic Be star it rotates near the critical velocity. The critical rotation frequency of a typical B5-6 star is about 3.5 c d-1 (40.5 μHz), which implies that the above frequencies are really caused by stellar pulsations rather than star's rotation. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  7. Una Visita al Viejo San Juan (A Visit to Old San Juan).

    ERIC Educational Resources Information Center

    Cabello, Victor; And Others

    Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

  8. 78 FR 35593 - Special Local Regulation; Christmas Boat Parade, San Juan Harbor; San Juan, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-13

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulation; Christmas Boat Parade, San... Juan, Puerto Rico during the Christmas Boat Parade, a Boat Parade. The event is scheduled to take place... United States during the Christmas Boat Parade. D. Discussion of Proposed Rule On December 14, 2013, Club...

  9. Chinanteco de San Juan Lealao, Oaxaca (Chinantec of San Juan Lealao, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Chinantec, an indigenous language of Mexico spoken in San Juan Lealao, in the state of Oaxaca. The objective of collecting such a representative sampling of…

  10. Trique de San Juan Copala, Oaxaca (Trique of San Juan Copala, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Trique, an indigenous language of Mexico spoken in San Juan Copala, in the state of Oaxaca. The objective of collecting such a representative sampling of the…

  11. Una Visita al Viejo San Juan (A Visit to Old San Juan).

    ERIC Educational Resources Information Center

    Cabello, Victor; And Others

    Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

  12. 77 FR 47358 - San Juan National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... Forest Service San Juan National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The San Juan National Forest Resource Advisory Council (RAC) will meet in... recommendations to the Forest Service concerning projects and funding consistent with Title II of the Act. The...

  13. Juan's Dilemma: A New Twist on the Old Lemon Battery

    ERIC Educational Resources Information Center

    Hunt, Vanessa; Sorey, Timothy; Balandova, Evguenia; Palmquist, Bruce

    2010-01-01

    When life hands you lemons, make a battery! In this article, the authors describe an activity they refer to as "Juan's Dilemma," an extension of the familiar lemon-battery activity (Goodisman 2001). Juan's Dilemma integrates oxidation and reduction chemistry with circuit theory in a fun, real-world exercise. The authors designed this activity for…

  14. 33 CFR 80.1385 - Strait of Juan de Fuca.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Strait of Juan de Fuca. 80.1385 Section 80.1385 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Thirteenth District § 80.1385 Strait of Juan de Fuca. The 72 COLREGS shall apply on all waters of...

  15. Juan's Dilemma: A New Twist on the Old Lemon Battery

    ERIC Educational Resources Information Center

    Hunt, Vanessa; Sorey, Timothy; Balandova, Evguenia; Palmquist, Bruce

    2010-01-01

    When life hands you lemons, make a battery! In this article, the authors describe an activity they refer to as "Juan's Dilemma," an extension of the familiar lemon-battery activity (Goodisman 2001). Juan's Dilemma integrates oxidation and reduction chemistry with circuit theory in a fun, real-world exercise. The authors designed this activity for…

  16. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the security...

  17. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the security...

  18. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the security...

  19. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. (a.... Coast Guard or U.S. naval vessels. (c) Regulations. (1) No person or vessel may enter into the security...

  20. Correction to Clark and Ro (2014).

    PubMed

    2015-01-01

    Reports an error in "Three-pronged assessment and diagnosis of personality disorder and its consequences: Personality functioning, pathological traits, and psychosocial disability" by Lee Anna Clark and Eunyoe Ro (Personality Disorders: Theory, Research, and Treatment, 2014[Jan], Vol 5[1], 55-69). There was an error in the results. Under the subheading, Personality Traits-Functioning Relations, on page 63, the second, third, and fourth paragraph have been revised. The revisions are included in the erratum. (The following abstract of the original article appeared in record 2014-07188-003.) The alternative dimensional model of personality disorder (PD) in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association, 2013), Section III, has two main criteria: impairment in personality functioning and one or more pathological personality traits. The former is defined as disturbances in self-functioning (viz., identity, self-direction), and/or interpersonal functioning (viz., empathy, intimacy). Distinguishing personality functioning and traits is important conceptually, because simply having extreme traits is not necessarily pathological. However, adding personality functioning to PD diagnosis represents an empirical challenge, because the constructs overlap conceptually. Further, there is debate regarding whether diagnosis of mental disorder requires either distress or disability, concepts that also overlap with maladaptive-range personality traits and personality dysfunction. We investigated interrelations among these constructs using multiple self-report measures of each domain in a mixed community-patient sample (N = 402). We examined the structures of functioning (psychosocial disability and personality) and personality traits, first independently, then jointly. The disability/functioning measures yielded the 3 dimensions we have found previously (Ro & Clark, 2013). Trait measures had a hierarchical structure

  1. CoRoT in Brief

    NASA Astrophysics Data System (ADS)

    Boisnard, L.; Auvergne, M.

    2006-11-01

    The CoRoT Space Telescope is an experiment of astronomy dedicated to stellar seismology and search for extrasolar planets. The mission is led by CNES in association with French laboratories and with a significant international participation: ESA (Science Programme and RSSD/ESTEC, Austria, Belgium, Germany contribute to the payload, whereas Spain and Brazil (who has recently joined the project) contribute to the ground segment. Based on a PROTEUS low earth orbit recurrent platform, the spacecraft has been in development since October 2000 for a launch scheduled in Ocotber 2006. It gives an overview of the experiment, explains where the critical scientific requirements are for payload engineering and describes the cost-effective compromises found for high accuracy photometry in low earth orbit. We run through the different families of perturbations due to the interaction between the spacecraft and its environment and illustrate how some noise contributors, which generate spectral lines likely to be misinterpreted as a component of the star signal, are reduced by design, avoided by an appropriate mission profile or corrected after calibration. We focus on the following technical issues: telescope baffling and orbital drift, pointing stability, optoelectronics thermal regulation, light curve processing

  2. Assuring the Legacy of the CoRoT Planets

    NASA Astrophysics Data System (ADS)

    Deeg, H. J.; Klagyivik, P.; Alonso, R.; Hoyer, S.

    2015-09-01

    For the long-lasting impact of CoRoT's planet findings, precise knowledge of the times of their transits is of vital importance for any future observing campaigns. Here we give the motivation and first results of a systematic revisit of the transits of most CoRoT planets to refine their ephemeris. As secondary objectives, more precise planet characterisations, from period or transit shape variations on/and from use of a well-defined passband may be obtained.

  3. Transiting exoplanets from the CoRoT space mission. XVII. The hot Jupiter CoRoT-17b: a very old planet

    NASA Astrophysics Data System (ADS)

    Csizmadia, Sz.; Moutou, C.; Deleuil, M.; Cabrera, J.; Fridlund, M.; Gandolfi, D.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Carone, L.; Carpano, S.; Cavarroc, C.; Cochran, W.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Endl, M.; Erikson, A.; Ferraz-Mello, S.; Fruth, Th.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

    2011-07-01

    We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of 2.43 ± 0.30 MJup and a radius of 1.02 ± 0.07 RJup, while its mean density is 2.82 ± 0.38 g/cm3. CoRoT-17b is in a circular orbit with a period of 3.7681 ± 0.0003 days. The host star is an old (10.7 ± 1.0 Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain ~380 earth masses of heavier elements. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  4. Metric-driven RoSy field design and remeshing.

    PubMed

    Lai, Yu-Kun; Jin, Miao; Xie, Xuexiang; He, Ying; Palacios, Jonathan; Zhang, Eugene; Hu, Shi-Min; Gu, Xianfeng

    2010-01-01

    Designing rotational symmetry fields on surfaces is an important task for a wide range of graphics applications. This work introduces a rigorous and practical approach for automatic N-RoSy field design on arbitrary surfaces with user-defined field topologies. The user has full control of the number, positions, and indexes of the singularities (as long as they are compatible with necessary global constraints), the turning numbers of the loops, and is able to edit the field interactively. We formulate N-RoSy field construction as designing a Riemannian metric such that the holonomy along any loop is compatible with the local symmetry of N-RoSy fields. We prove the compatibility condition using discrete parallel transport. The complexity of N-RoSy field design is caused by curvatures. In our work, we propose to simplify the Riemannian metric to make it flat almost everywhere. This approach greatly simplifies the process and improves the flexibility such that it can design N-RoSy fields with single singularity and mixed-RoSy fields. This approach can also be generalized to construct regular remeshing on surfaces. To demonstrate the effectiveness of our approach, we apply our design system to pen-and-ink sketching and geometry remeshing. Furthermore, based on our remeshing results with high global symmetry, we generate Celtic knots on surfaces directly.

  5. GCM simulated geopotential heights compared to GPS RO data

    NASA Astrophysics Data System (ADS)

    Molodtsov, S.; Kirilenko, A.; Olsen, D.

    2012-12-01

    Accurate, high-quality, global coverage data is required for global climate monitoring. It also provides possibility of additional validation of the general circulation models (GCMs). GPS Radio occultation (GPS RO) measurements have potential of becoming a new benchmark in data acquisition, providing new high-quality profiles of the parameters of the atmosphere, such as the temperature, water vapor pressure, and geopotential heights. In our study we use GPS RO data with a purpose to test global circulation models (GCMs). We study how climate change signal emerges in the GPS RO data and how these signals are reflected in GCM simulations. We use temperature and geopotential height profiles from 2001-2006 CHAMP and 2006-2011 COMIC acquisitions to validate the output from twelve IPCC AR4 GCMs run under A1B SRES scenario. We found that the 2001-2011 trends of the temperature and geopotential height derived from the IPCC AR4 GCMs show the same pattern with trends derived from GPS RO data - warming of the upper troposphere (UT) and cooling of the lower stratosphere (LS). There is some discrepancy between trends in lower troposphere (LT) between models and GPS RO data: some GCMs show decreasing temperature and geopotential height trends while the GPS RO trends are positive. The statistical analysis of these trends will be reported.

  6. Higher order multi-dimensional extensions of Cesàro theorem

    NASA Astrophysics Data System (ADS)

    Accardi, Luigi; Ji, Un Cig; Saitô, Kimiaki

    2015-12-01

    The Cesàro theorem is extended to the cases: (1) higher order Cesàro mean for sequence (discrete case); and (2) higher order, multi-dimensional and continuous Cesàro mean for functions. Also, we study the Cesàro theorem for the case of positive-order.

  7. VizieR Online Data Catalog: CoRoT/Exoplanet fields with MATISSE (Gazzano+, 2010)

    NASA Astrophysics Data System (ADS)

    Gazzano, J.-C.; de Laverny, P.; Deleuil, M.; Recio-Blanco, A.; Bouchy, F.; Moutou, C.; Bijaoui, A.; Ordenovic, C.; Gandoli, D.; Loeillet, B.

    2010-11-01

    Atomic data modifications from VALD initial request, atmospheric parameters for 1227 CoRoT targets, radial velocity for 1534 CoRoT targets, and Vsini for 1604 CoRoT targets in three CoRoT/Exoplanet fields LRa01, LRc01, and SRc01. The reported uncertainties are only internal errors. (6 data files).

  8. Model Simulations of Waves in Hurricane Juan

    NASA Astrophysics Data System (ADS)

    Perrie, W.; Toulany, B.; Padilla-Hernandez, R.; Hu, Y.; Smith, P.; Zhang, W.; Zou, Q.; Ren, X.

    2004-05-01

    Hurricane Juan made landfall at 0300 UTC near Halifax Nova Scotia. This was a category 2 hurricane with winds of 44 m/s, the largest storm to pass over these coastal areas in several decades. Associated high ocean waves were experienced in coastal waters, from Peggy's Cove to Sheet Harbour, growing to epic proportions on the Scotian Shelf, and exceeding the 100-year return wave based on the present climatology. As part of the GoMOOS program (Gulf of Maine Ocean Observing System, www.gomoos.org), winds from the USA Navy COAMPS (Coupled Ocean Atmosphere Model Prediction System) were used to evaluate and compare three widely-used third generation numerical wave models, SWAN, WAM and WaveWatch-III (hereafter WW3) for accuracy, with in situ measurements. Model comparisons consist of a set of composite model systems, respectively nesting WAM, WW3 and SWAN in WAM and WW3. We report results from the intermediate-resolution grid for Hurricane Juan. Wave measurements were made using four operational deep-water buoys (C44258, C44142, C44137, 44005), by a conventional directional wave rider (DWR) moored offshore from Lunenburg Bay, and also by two acoustic Doppler current profiler (ADCP) located (1) near an oil rig on Sable Island Bank, in relatively shallow water, and (2) near the outer boundary of Lunenburg Bay. We discuss the reliability of DWR wave data compared to ADCP wave data. We show that all models provide reliable hindcasts for significant wave height (Hs) and for peak period (Tp) for Juan, although a clear under-estimation of Hs at the peak of the storm is evident, compared to observations. A feature in the COAMPS storm simulation is that the storm track appears to be slightly to the east of that of Quikscat scatterometer data. Comparisons between models and 2-dimensional wave spectra are presented. Preliminary results suggest that the recently released upgrade to the WW3 model shows slightly enhanced skill compared to the other models.

  9. RadNet Air Data From San Juan, PR

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for San Juan, PR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  10. Availability of hydrologic data in San Juan County, New Mexico

    USGS Publications Warehouse

    Klausing, R.L.; Welder, G.E.

    1984-01-01

    San Juan County, in the northwestern corner of New Mexico, uses surface water from the San Juan, Animas, and La Plata Rivers as a principal source of water for the county, but the water in these streams is fully appropriated. Ground water is present in San Juan County in several bedrock formations and in the alluvium of the river valleys. This report describes the hydrologic data that have been collected in San Juan County, presents examples of the data, shows the locations of the data-collection sites, and indicates where more complete records may be obtained. This data base should be helpful in assessing the quantity, quality, and availability of the county 's water resources. Information collected at 1,877 water wells, 39 streamflow-gaging stations, and 172 springs is presented. The collection sites and geology are shown on a base map with a scale of 1 inch = 2 miles. (USGS).

  11. Clinical and laboratory aspects of Ro/SSA-52 autoantibodies.

    PubMed

    Defendenti, Caterina; Atzeni, Fabiola; Spina, Maria Francesca; Grosso, Silvia; Cereda, Aldo; Guercilena, Giacinto; Bollani, Simona; Saibeni, Simone; Puttini, Piercarlo Sarzi

    2011-01-01

    Anti-Ro/SSA antibodies, which were described for the first time in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS), are the most prevalent extractable nuclear antigen (ENA) specificity identified in laboratories. Two types of anti-Ro/SSA antibodies have been described, anti-SSA-52 kDa (aSSA52) and anti-SSA-60 kDa (aSSA60), each specific to different antigens. Anti-Ro/SSA52 autoantibodies are more frequent than other autoantibodies possibly because of the antigen's accessible and ubiquitous nature. The sites involved and the symptoms associated with these autoantibodies depend on the antigen's structural variability. Isolated congenital complete atrioventricular block (CAVB) shows a close association with maternal anti-Ro/SSA and anti-La/SSB antibodies; the highest relative risks of CAVB are seen in offspring of mothers with antibodies against 52-kDa Ro and 48-kDa La proteins. Anti-Ro/SSA52 antibodies have little impact on adult rheumatic autoimmune diseases or adult cardiac arrhythmias, but the course of autoimmune liver diseases is greatly worsened by their presence, and solid tumours tend to relapse. Their diagnostic role in rheumatic diseases is controversial, although a significant association between isolated anti-Ro/SSA52-kDa positivity and myositis and to a lesser extent with systemic sclerosis (SSc) has been described. However, the majority of the specific diagnosis is mostly based on the simultaneous presence of other autoantibodies that seems diagnostically more relevant.

  12. Juan-Ron fever: A rare case report.

    PubMed

    Acharya, Sourya; Shukla, Samarth

    2015-01-01

    Juan-Ron fever named after Juan Rosai and Ronald Dorfman is the fever associated with Rosai-Dorfman disease also known as sinus histiocytosis with massive lymphadenopathy (SHML). It is a rare disorder of unknown etiology that is characterized by abundant macrophages in the lymph nodes throughout the body. Usually patient presents with painless lymphadenopathy. We present a case of a 45-year-old male who presented to us with bilateral cervical lymphadenopathy and fever, later on diagnosed to have SHML.

  13. SU-E-T-218: The IHE-RO Helper Tool: Demonstrating the Connectivity Issues Solved by IHE-RO.

    PubMed

    Kapoor, Rishabh; Yeung, Daniel; Kumar, Sabari Ajay; Alex, Daley; Kapur, Priyanka; Palta, Jatinder

    2012-06-01

    To develop a Web-based application (IHE-RO Helper) to allow comprehensive review of the interconnectivity and interoperability of various radiotherapy devices established through testing sanctioned by the Integrating Healthcare Enterprise-Radiation Oncology (IHE-RO). IHE-RO is an initiative sponsored by ASTRO to improve the way computer based systems in radiation oncology share information using well-defined data exchange standards (DICOM / HL7). At the IHE-RO Connectathon events over the last 4 years, 11 vendors with 14 different products have successfully tested and identified solutions to connectivity problems in treatment planning, simulation and delivery. Because the test results are highly technical, the interconnectivity issues amongst the RT devices may get overlooked by the end users. The IHE-RO helper tool is designed to operate in simple clinical terms with queries and presentations organized based on treatment techniques and clinical features that are familiar to the practitioners. For example, if you are planning to purchase a treatment planning system capable of generating plans (e.g. Stereotactic treatments) and are concerned whether the TPS can successfully transfer such data to your treatment management system (TMS) and subsequently to your treatment delivery system (TDS), the IHE-RO Helper can identify the connectivity requirements and list vendors that have successfully passed an IHE-RO Connectathon and validated their solution to the specific requirements. The IHE-RO helper tool provides a graphical and textual user interface to effectively demonstrate the solved interconnectivity problems between TPS, TMS and TDS. A report is also provided that explains the interconnectivity problems and its solutions. The IHE-RO helper is an effective tool to clearly identify vendor products that are IHE-RO compliant, thereby encourages vendor participation in testing and validation. Such a tool will be invaluable in procurement of new equipment to ensure a

  14. CoRoT: Harvest of the exoplanet program

    NASA Astrophysics Data System (ADS)

    Moutou, Claire; Deleuil, Magali; Guillot, Tristan; Baglin, Annie; Bordé, Pascal; Bouchy, Francois; Cabrera, Juan; Csizmadia, Szilárd; Deeg, Hans J.

    2013-11-01

    One of the objectives of the CoRoT mission is the search for transiting extrasolar planets using high-precision photometry, and the accurate characterization of their fundamental parameters. The CoRoT satellite consecutively observes crowded stellar fields since February 2007, in high-cadence precise photometry; periodic eclipses are detected and analyzed in the stellar light curves. Then complementary observations using ground-based facilities allows establishing the nature of the transiting body and its mass. CoRoT has acquired more than 163,000 light curves and detected about 500 planet candidates. A fraction of them (5%) are confirmed planets whose masses are independently measured. Main highlights of the CoRoT discoveries are: (i) the variety of internal structures in close-in giant planets, (ii) the characterization of the first known transiting rocky planet, CoRoT-7b, and (iii) multiple constraints on the formation, evolution, role of tides in planetary systems.

  15. CoRoT data reduction by example

    NASA Astrophysics Data System (ADS)

    Weingrill, J.

    2015-02-01

    Data reduction techniques published so far for the CoRoT N2 data product were targeted primarily on the detection of extrasolar planets. Since the whole dataset has been released, specific algorithms are required to process the lightcurves from CoRoT correctly. Though only unflagged datapoints must be chosen for scientific processing, some flags might be reconsidered. The reduction of data along with improving the signal-to-noise ratio can be achieved by applying a one dimensional drizzle algorithm. Gaps can be filled by linear interpolated data without harming the frequency spectrum. Magnitudes derived from the CoRoT color channels might be used to derive additional information about the targets. Depending on the needs, various filters in the frequency domain remove either the red noise background or high frequency noise. The autocorrelation function or the least squares periodogram are appropriate methods to identify periodic signals. The methods described here are not strictly limited to CoRoT data but may also be applied on Kepler data or the upcoming PLATO mission. The CoRoT space mission, launched on 2006 December 27, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain.

  16. 33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to Point 6 at 18°27′46″ N, 066°07′10″ W; then back to shore at the northwest end of the CG facility... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Coast Guard Base... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a...

  17. Evaluation of RO modules for the SSP ETC/LSS.

    NASA Technical Reports Server (NTRS)

    Jasionowski, W. J.; Bambenek, R. A.

    1973-01-01

    During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

  18. Evaluation of RO modules for the SSP ETC/LSS.

    NASA Technical Reports Server (NTRS)

    Jasionowski, W. J.; Bambenek, R. A.

    1973-01-01

    During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

  19. The opacity mechanism in roAp stars

    NASA Astrophysics Data System (ADS)

    Cunha, Margarida S.; Gough, Douglas

    2001-01-01

    In the present paper we present the first results of work whose main goal is to understand the details of the process of high-order mode excitation in roAp stars. Motivated by the work by Balmforth et al. (1999, 2000), according to which convection might be suppressed in the polar regions of roAp stars, we show that in a radiative region the excitation of high-order pulsations takes place in the region of hydrogen ionization, and is the direct consequence of the abrupt change in the opacity derivative κT = (∂lnκ/∂lnT)ρ in these layers.

  20. AmeriFlux US-Ro3 Rosemount- G19

    SciTech Connect

    Baker, John; Griffis, Tim

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro3 Rosemount- G19. Site Description - This tower is located in a farm field farmed in accordance with the cominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  1. AmeriFlux US-Ro1 Rosemount- G21

    SciTech Connect

    Baker, John; Griffis, Tim; Griffis, Timothy

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ro1 Rosemount- G21. Site Description - This tower is located in a farm field farmed in accordance with the dominant farming practice in the region: a corn/soybean rotation with chisel plow tillage in the fall following corn harvest and in the spring following soybeans.

  2. StRoBe: A Classroom-on-Task Measure.

    ERIC Educational Resources Information Center

    Marchant, Gregory J.

    Researchers as well as others evaluating teachers or programs are often interested in the verbal and non-verbal behaviors related to the learning of students in classrooms. The Student Record of Behavior (StRoBe) is a classroom observation instrument designed to provide simple low inference information concerning student behaviors related to…

  3. Asteroseismology of OB stars with CoRoT

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Samadi, R.; Miglio, A.; Briquet, M.; Auvergne, M.; Baglin, A.; Baudin, F.; Catala, C.; Michel, E.

    2010-12-01

    The CoRoT satellite is revolutionizing the photometric study of massive O-type and B-type stars. During its long runs, CoRoT observed the entire main sequence B star domain, from typical hot β Cep stars, via cooler hybrid p- and g-mode pulsators to the SPB stars near the edge of the instability strip. CoRoT lowers the sensitivity barrier from the typical mmag-precision reached from the ground, to the μmag-level reached from space. Within the wealth of detected and identified pulsation modes, relations have been found in the form of multiplets, combination of frequencies, and frequency- and period spacings. This wealth of observational evidence is finally providing strong constraints to test current models of the internal structure and pulsations of hot stars. Aside from the expected opacity driven modes with infinite lifetime, other unexpected types of variability are detected in massive stars, such as modes of stochastic nature. The simultaneous observation of all these light curve characteristics implies a challenge for both observational asteroseismology and stellar modelling. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

  4. Removing Arsenic with a Softening/RO Combo

    EPA Science Inventory

    This paper provides a very short summary of the arsenic demonstration program and the limited test results from the point-of-use (POU), reverse osmosis (RO) project in Homedale, ID. Preformance data is presented on the effectiveness of the POU treatment system to remove arseni...

  5. Removing Arsenic with a Softening/RO Combo

    EPA Science Inventory

    This paper provides a very short summary of the arsenic demonstration program and the limited test results from the point-of-use (POU), reverse osmosis (RO) project in Homedale, ID. Preformance data is presented on the effectiveness of the POU treatment system to remove arseni...

  6. Isotretinoin (Ro-Accutane) teratogenesis. A case report.

    PubMed

    Giannoulis, C H; Papathanasiou, K; Tantanasis, T H; Vaitsi, V; Tzafettas, I

    2005-01-01

    A case of teratogenesis in a 16-year-old pregnant patient is described. She had been using 60 mg Ro-Accutane daily till the 16th week of gestation. Sonography showed no cephalic skull up to the frontal bone of the fetus. A central lagostroma was also detected.

  7. Empirical Error Analysis of GPS RO Atmospheric Profiles

    NASA Astrophysics Data System (ADS)

    Scherllin-Pirscher, B.; Steiner, A. K.; Foelsche, U.; Kirchengast, G.; Kuo, Y.

    2010-12-01

    In the upper troposphere and lower stratosphere (UTLS) region the radio occultation (RO) technique provides accurate profiles of atmospheric parameters. These profiles can be used in operational meteorology (i.e., numerical weather prediction), atmospheric and climate research. We present results of an empirical error analysis of GPS RO data retrieved at UCAR and at WEGC and compare data characteristics of CHAMP, GRACE-A, and Formosat-3/COSMIC. Retrieved atmospheric profiles of bending angle, refractivity, dry pressure, dry geopotential height, and dry temperature are compared to reference profiles extracted from ECMWF analysis fields. This statistical error characterization yields a combined (RO observational plus ECMWF model) error. We restrict our analysis to the years 2007 to 2009 due to known ECMWF deficiencies prior to 2007 (e.g., deficiencies in the representation of the austral polar vortex or the weak representation of tropopause height variability). The GPS RO observational error is determined by subtracting the estimated ECMWF error from the combined error in terms of variances. Our results indicate that the estimated ECMWF error and the GPS RO observational error are approximately of the same order of magnitude. Differences between different satellites are small below 35 km. The GPS RO observational error features latitudinal and seasonal variations, which are most pronounced at stratospheric altitudes at high latitudes. We present simplified models for the observational error, which depend on a few parameters only (Steiner and Kirchengast, JGR 110, D15307, 2005). These global error models are derived from fitting simple analytical functions to the GPS RO observational error. From the lower troposphere up to the tropopause, the model error decreases closely proportional to an inverse height law. Within a core "tropopause region" of the upper troposphere/lower stratosphere the model error is constant and above this region it increases exponentially with

  8. The Forts of Old San Juan: Guardians of the Caribbean. Teaching with Historic Places.

    ERIC Educational Resources Information Center

    Weltzin, Rosanna

    The massive masonry defenses of Old San Juan, Puerto Rico, which were begun in the 16th century, exist today as the oldest European-style fortifications within the territory of the United States. This lesson is based on the World Heritage Site nomination file and the National Park Service Handbook, "San Juan: The Forts of Old San Juan."…

  9. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  10. 33 CFR 167.1312 - In the Strait of Juan de Fuca: Southern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1312 In the Strait of Juan de Fuca: Southern lanes. In the southern lanes of the Strait of Juan de Fuca, the following...

  11. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  12. 33 CFR 167.1314 - In the Strait of Juan de Fuca: Eastern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1314 In the Strait of Juan de Fuca: Eastern lanes. In the eastern lanes of the Strait of Juan de Fuca, the following are...

  13. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  14. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  15. 33 CFR 167.1313 - In the Strait of Juan de Fuca: Northern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1313 In the Strait of Juan de Fuca: Northern lanes. In the northern lanes of the Strait of Juan de Fuca, the following...

  16. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  17. 33 CFR 167.1314 - In the Strait of Juan de Fuca: Eastern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1314 In the Strait of Juan de Fuca: Eastern lanes. In the eastern lanes of the Strait of Juan de Fuca, the following are...

  18. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  19. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  20. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  1. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  2. 33 CFR 167.1312 - In the Strait of Juan de Fuca: Southern lanes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1312 In the Strait of Juan de Fuca: Southern lanes. In the southern lanes of the Strait of Juan de Fuca, the following...

  3. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  4. 33 CFR 167.1310 - In the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Separation Schemes and Precautionary Areas Pacific West Coast § 167.1310 In the Strait of Juan de Fuca: General. The traffic separation scheme in the Strait of Juan de Fuca consists of five parts: the...

  5. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W....

  6. 33 CFR 167.1313 - In the Strait of Juan de Fuca: Northern lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1313 In the Strait of Juan de Fuca: Northern lanes. In the northern lanes of the Strait of Juan de Fuca, the following...

  7. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  8. 33 CFR 167.1311 - In the Strait of Juan de Fuca: Western lanes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1311 In the Strait of Juan de Fuca: Western lanes. In the western lanes of the Strait of Juan de Fuca, the following are...

  9. 33 CFR 167.1300 - In the approaches to the Strait of Juan de Fuca: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Juan de Fuca: General. 167.1300 Section 167.1300 Navigation and Navigable Waters COAST GUARD... approaches to the Strait of Juan de Fuca: General. The traffic separation scheme for the approaches to the Strait of Juan de Fuca consists of three parts: the western approach, the southwestern approach,...

  10. Cesàro operators on Hardy spaces in the unit ball

    NASA Astrophysics Data System (ADS)

    Guo, Xiaoqin; Ren, Guangbin

    2008-03-01

    This article establishes the boundedness of the generalized Cesàro operator on holomorphic Hardy spaces in the unit ball. The approach consists in writing the generalized Cesàro operator as a composition of certain integral operators.

  11. Comparison of antibody assays for detection of autoantibodies to Ro 52, Ro 60 and La associated with primary Sjögren's syndrome.

    PubMed

    Trier, Nicole Hartwig; Nielsen, Inger Ødum; Friis, Tina; Houen, Gunnar; Theander, Elke

    2016-06-01

    Anti-Ro(52/60) and anti-La constitute the hallmark autoantibodies in primary Sjögren's syndrome, being present in 40-70% of sera. Several anti-Ro/La assays exist, but antibody detection appears to be assay-specific, thus the aim of this study was to compare several anti-Ro/La assays. In total, 96 sera from individuals with primary Sjögren's syndrome and 114 healthy controls were tested for anti-Ro 52/60 and anti-La in 17 immunoassays. Especially the immunoassays used for detection of anti-Ro 52 differed in their sensitivity (48-79%), while only small differences in sensitivities were observed for the anti-Ro 60 (69-77%) anti-La (39-44%) assays. Concordances of 65%, 79% and 73% for the anti-Ro 52, anti-Ro 60 and anti-La assays were found, respectively. The majority of the assays yielded high specificities, primarily ranging from 97 to 100%, except from a single anti-Ro 60 assay, which yielded a specificity of 79%. Occasionally, reactivity levels were increased in a few assays, indicating that false-positive results can be obtained when applying assays of reduced specificity. In general, the commercial assays appeared to perform better than the in-house analyses. When correcting the in-house assays for background reactivity, sensitivities were reduced by approximately 7%, 17%, and 19% for anti-Ro 52, anti-Ro 60 and anti-La assays, respectively, illustrating the pitfalls when applying immunoassays for detection of autoantibodies, which in theory may apply to commercial assays as well. Finally, increased total sensitivities were obtained when combining assays. These studies contribute to clarify the clinical utility of immunoassays for detection of autoantibodies of Ro 52, Ro 60 and La and illustrate that the most efficient strategy to maximize antibody sensitivity is to combine several assays.

  12. Common and specific associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies in systemic lupus erythematosus.

    PubMed

    Menéndez, Aurora; Gómez, Jesús; Caminal-Montero, Luis; Díaz-López, José Bernardino; Cabezas-Rodríguez, Iván; Mozo, Lourdes

    2013-01-01

    Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and P = 0.019, resp.) and anti-Ro52/TRIM21 (P = 0.026 and P = 0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P = 0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P = 0.041), mainly with low C4 levels (P = 0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud's phenomenon (P = 0.026) and cytopenia (P = 0.048) and negatively associated with anti-dsDNA (P = 0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P = 0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.

  13. Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection.

    PubMed

    Menéndez, Aurora; Gómez, Jesús; Escanlar, Esther; Caminal-Montero, Luis; Mozo, Lourdes

    2013-02-01

    Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies are not yet fully established. In order to analyse the diagnostic utility of their separate detection, we retrospectively revised the clinical data of 200 anti-SSA/Ro60 and/or anti-Ro52/TRIM21 positive patients identified by line immunoassay during ANA routine detection. Anti-SSA/Ro60 positive patients showed a significantly higher prevalence of autoimmune diseases (AIDs) independently on the presence of anti-Ro52/TRIM21 (OR 3.13, 95% CI 1.10-8.88, p = 0.032). Anti-SSA/Ro60 was independently associated with systemic lupus erythematosus (SLE) when comparing with Sjögren's syndrome (SS) and other systemic AIDs (OR 3.46, 95% CI 1.08-11.06, p = 0.036). The more frequent specificity found in cutaneous lupus erythematosus (CLE) was also anti-SSA/Ro60. In contrast, detection of isolated anti-Ro52/TRIM21 was characteristic of SS (7/35, 20.0%), diffuse cutaneous systemic sclerosis (dcSSc) (3/4, 75.0%), primary biliary cirrhosis (PBC) (4/5, 80.0%) and, specially, of polymyositis/dermatomyositis (PM/DM) (6/6, 100%). In fact, anti-Ro52/TRIM21 was the only antibody detected in 4 out of the 6 PM/DM patients. Malignancies mainly account for the observed high prevalence of mono-specific anti-Ro52/TRIM21 in patients with non-AIDs (10/15, 62.5%). In conclusion, this retrospective study supports the routine distinction of anti-SSA/Ro60 and anti-Ro52/TRIM21 due to their different clinical associations.

  14. Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

    PubMed Central

    Menéndez, Aurora; Gómez, Jesús; Caminal-Montero, Luis; Díaz-López, José Bernardino; Cabezas-Rodríguez, Iván; Mozo, Lourdes

    2013-01-01

    Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and P = 0.019, resp.) and anti-Ro52/TRIM21 (P = 0.026 and P = 0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P = 0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P = 0.041), mainly with low C4 levels (P = 0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud's phenomenon (P = 0.026) and cytopenia (P = 0.048) and negatively associated with anti-dsDNA (P = 0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P = 0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease. PMID:24294139

  15. Gene encoding human Ro-associated autoantigen Y5 RNA.

    PubMed Central

    Maraia, R; Sakulich, A L; Brinkmann, E; Green, E D

    1996-01-01

    Ro ribonucleoproteins are composed of Y RNAs and the Ro 60 kDa protein. While the Ro 60 kDa protein is implicated in an RNA discard pathway that recognizes 3'-extended 5S rRNAs, the function of Y RNAs remains unknown [O'Brien,C.A. and Wolin,S.L. (1995) Genes Dev. 8,2891-2903]. Y5 RNA occupies a large fraction of Ro 60 kDa protein in human Ro RNPs, contains an atypical 3'-extension not found on other Y RNAs, and constitutes an RNA antigen in certain autoimmune patients [Boulanger et al. (1995) Clin. Exp. Immunol. 99, 29-36]. An overabundance of Y RNA retroposed pseudogenes has previously complicated the isolation of mammalian Y RNA genes. The source gene for Y5 RNA was isolated from human DNA as well as from Galago senegalis DNA. Authenticity of the hY5 RNA gene was demonstrated in vivo and its activity was compared with the hY4 RNA gene that also uses a type 3 promoter for RNA polymerase III. The hY5 RNA gene was subsequently found to reside within a few hundred thousand base pairs of other Y RNA genes and the linear order of the four human Y RNA genes on chromosome 7q36 was determined. Phylogenetic comparative analyses of promoter and RNA structure indicate that the Y5 RNA gene has been subjected to positive selection during primate evolution. Consistent with the proposal of O'Brien and Harley [O'Brian,C.A. and Wolin,S.L. (1992) Gene 116, 285-289], analysis of flanking sequences suggest that the hY5 RNA gene may have originated as a retroposon. PMID:8836182

  16. Physiography and Quaternary geology of the San Juan Mountains, Colorado

    USGS Publications Warehouse

    Atwood, Wallace W.; Mather, Kirtley F.

    1932-01-01

    appeared from time to time as folios"' of the Geologic Atlas and reports on the economic geology of the mining districts, published by the United States Geological Survey between 1899 and 1910. Gradually the concept of the geologic problems was changed. Instead of considering individual mining districts as the units of investigation it became apparent that the San Juan region must itself be the unit. In 1908 Mr. Cross drafted plans for the completion of the San Juan studies on this enlarged basis. His aim was to arrange for the publication of papers on different subjects rather than one huge monograph on the region as a whole.

  17. LOD First Estimates In 7406 SLR San Juan Argentina Station

    NASA Astrophysics Data System (ADS)

    Pacheco, A.; Podestá, R.; Yin, Z.; Adarvez, S.; Liu, W.; Zhao, L.; Alvis Rojas, H.; Actis, E.; Quinteros, J.; Alacoria, J.

    2015-10-01

    In this paper we show results derived from satellite observations at the San Juan SLR station of Felix Aguilar Astronomical Observatory (OAFA). The Satellite Laser Ranging (SLR) telescope was installed in early 2006, in accordance with an international cooperation agreement between the San Juan National University (UNSJ) and the Chinese Academy of Sciences (CAS). The SLR has been in successful operation since 2011 using NAOC SLR software for the data processing. This program was designed to calculate satellite orbits and station coordinates, however it was used in this work for the determination of LOD (Length Of Day) time series and Earth Rotation speed.

  18. Stellar classification of CoRoT targets

    NASA Astrophysics Data System (ADS)

    Damiani, C.; Meunier, J.-C.; Moutou, C.; Deleuil, M.; Ysard, N.; Baudin, F.; Deeg, H.

    2016-11-01

    Context. The CoRoT mission was the first dedicated to the search for exoplanets from space. The CoRoT exoplanet channel observed about 163 600 targets to detect transiting planetary companions. In addition to the search for exoplanets, the extremely precise photometric time series provided by CoRoT for this vast number of stars is an invaluable resource for stellar studies. Because CoRoT targets are faint (11 ≤ r ≤ 16) and close to the galactic plane, only a small subsample has been observed spectroscopically. Consequently, the stellar classification of CoRoT targets required the design of a classification method suited for the needs and time frame of the mission. Aims: We describe the latest classification scheme used to derive the spectral type of CoRoT targets, which is based on broadband multi-colour photometry. We assess the accuracy of this spectral classification for the first time. Methods: We validated the method on simulated data. This allows the quantification of the effect of different sources of uncertainty on the spectral type. Using galaxy population synthesis models, we produced a synthetic catalogue that has the same properties as the CoRoT targets. In this way, we are able to predict typical errors depending on the estimated luminosity class and spectral type. We also compared our results with independent estimates of the spectral type. Cross-checking those results allows us to identify the systematics of the method and to characterise the stellar populations observed by CoRoT. Results: We find that the classification method performs better for stars that were observed during the mission-dedicated photometric ground-based campaigns.The luminosity class is wrong for less than 7% of the targets. Generally, the effective temperature of stars classified as early type (O, B, and A) is overestimated. Conversely, the temperature of stars classified as later type tends to be underestimated. This is mainly due to the adverse effect of interstellar

  19. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    ERIC Educational Resources Information Center

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in…

  20. San Juan College Task Force on Innovation 1995 Report.

    ERIC Educational Resources Information Center

    Moore, Nelle

    In fall 1994, San Juan College, in New Mexico, established the Task Force on Innovation to examine changes in the paradigm of education and how those changes might affect the college. The Task Force determined that the primary driver of change in education was technology, and specifically the increasing number of means and ease of access to…

  1. Local Control and Self-Determination: The San Juan Case.

    ERIC Educational Resources Information Center

    Garman, Keats; Jack, Donald

    Rapidly increasing Navajo enrollment in San Juan County, Utah, public schools in the 1960's forced the rural school district to improve educational services to a sizable Navajo population while attempting to preserve local control in the face of changing Indian self-determination policy. The district implemented a Curriculum Development Center, a…

  2. Ladrillo and Tales of Juan Bobo: Puerto Rican Folk Tales.

    ERIC Educational Resources Information Center

    Matos, Reinaldo; Matos, Ana

    These two illustrated elementary readers contain the Spanish and English versions of the Puerto Rican folk tales, "Ladrillo" and "Cuentos de Juan Bobo." They are part of a series of reading materials for elementary-level migrant children. These materials are intended to help the child relate to his culture, develop interest in…

  3. The green areas of San Juan, Puerto Rico

    Treesearch

    O.M. Ramos-Gonzalez

    2014-01-01

    Green areas, also known as green infrastructure or urban vegetation, are vital to urbanites for their critical roles in mitigating urban heat island effects and climate change and for their provision of multiple ecosystem services and aesthetics. Here, I provide a high spatial resolution snapshot of the green cover distribution of the city of San Juan, Puerto Rico, by...

  4. Las Cabezas de San Juan, Nature Reserve (El Faro).

    Treesearch

    P. L. Weaver; J. L. Ram¡rez; J. L. Coll

    1999-01-01

    The 178-hectarea(ha) northeastern tip of Puerto Rico, Which is known locally as "Las Cabezas de San Juan Nature Reserve", is managed by the Puerto Rican Conservation Trust to protect the area's scenic beauty and to provide enviromental education and research opportunities to the island's resident and visitors

  5. Juan Luis Vives: Tradition and Innovation in Renaissance Rhetoric.

    ERIC Educational Resources Information Center

    Abbott, Don Paul

    1986-01-01

    Argues that Juan Luis Vives' efforts to rehabilitate the discipline of discourse may well have been the most original of the sixteenth century, and that his discussion of elecutio (the essence of rhetoric) is considerably more distinguished than that of the better known Peter Ramus. (RS)

  6. Putting Educational Attainment First: An Interview with Juan Sepulveda

    ERIC Educational Resources Information Center

    Carreon, Joe

    2011-01-01

    This article presents an interview with Juan Sepulveda. Sepulveda was appointed by U.S. Secretary of Education Arne Duncan to the position of Executive Director of the White House Initiative on Educational Excellence for Hispanics on May 19, 2009. In this capacity, Sepulveda is responsible for directing the efforts of the White House Initiative in…

  7. Offshore finfish mariculture in the Strait of Juan de Fuca

    SciTech Connect

    Rensel, Jack; Kiefer, Dale; Forster, John R.; Woodruff, Dana L.; Evans, Nathan R.

    2007-10-07

    Finfish mariculture has existed in the U.S. Pacific Northwest for over thirty years, but for the past 15 years most effort has focused on culture of Atlantic salmon in protected, inshore cage sites. The Strait of Juan de Fuca (the "Strait") is a large area with relatively sparce shoreline development and several apparent advantages for mariculture using offshore technology.

  8. [Psychiatric Hospital San Juan de Dios. One hundred years later].

    PubMed

    Cocula-León, Horacio

    2014-01-01

    Mental health and psychiatric diseases have always attracted people's and health authorities' attention due to its magical approach, the lack of knowledge that surrounds them, and, at the same time, the religious fear they provoke. Both have played an important role in the history of humanity, of public health politics, and of physicians. The places where psychiatric patients were treated are of historical interest, because through the historical knowledge we can identify an approach from the science and the health policies that prevailed in each age. At the beginning of the 20th century, it was developed in México a new model of hospital care attention to psychiatric patients. La Casa de Salud San Juan de Dios para Pacientes Alienados is an example; the concept "alienated patients" suggests a social and cultural perspective. This paper presents a chronological type description of one of the major institutions involved in mental health care in México. Similarly, it shows a review of the events that affected the religious order San Juan de Dios from 1901 to 2012, when the hospitaller order was reinstated in México and established the Casa de Salud San Juan de Dios para Pacientes Alienados in the town of Zapopan, Jalisco, institution that exists up to the present day and keeps participating in the mental health care in the state of Jalisco, with the current name of Servicios de Salud San Juan de Dios.

  9. Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: mesoscopic simulation.

    PubMed

    Dai, Xingxing; Shi, Xinyuan; Wang, Yuguang; Qiao, Yanjiang

    2012-10-15

    Ginsenoside Ro (Ro), a natural anionic biosurfactant derived from ginseng, has been found to markedly increase the solubility of saikosaponin a (SSa), which is the active ingredient of Radix Bupleuri. SSa is minimally soluble in water. To determine the mechanism by which Ro solubilizes SSa, the self-assembly behavior of Ro and the phase behavior of blended Ro and SSa systems were studied by mesoscopic dynamics (MesoDyn) and dissipative particle dynamics (DPD) simulations. The simulation results show that Ro can form vesicles via the closure of oblate membranes. At low concentrations, SSa molecules are solubilized in the palisade layer of the Ro vesicles. At high concentrations, they interact with Ro molecules to form mixed vesicles with Ro adsorbing on the surfaces of the vesicles. The evaluation of the SSa solubilization process reveals that, at low concentrations, Ro aggregates preferentially to form vesicles, which then absorb SSa into themselves. However, at high concentrations, SSa first self-aggregates and then dissolves. This is because the solubilization behavior of Ro shifts the precipitation-dissolution equilibrium in the direction of dissolution. These results of the simulations are consistent with those of transmission electron microscopy (TEM) and dynamic light scattering (DLS). Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Climate Change detection using GPS RO and CMIP5 data

    NASA Astrophysics Data System (ADS)

    Molodtsov, S.; Kirilenko, A.; Olsen, D.

    2013-12-01

    General circulation models' (GCMs) response to the increase of atmospheric concentration of greenhouse gases (GHG) due to anthropogenic emissions is evident under variety of forcing scenarios. However the investigation of the anthropogenic signal in the real climate system is challenging as it requires long term high accuracy global coverage data. GPS Radio Occultation (GPS RO) technique becomes close to meeting all of these requirements, becoming the benchmark for climate data. We implemented the analysis for upper troposphere - lower stratosphere (UTLS) region between 50°N and 50°S latitudes, where the GPS RO data has higher quality. For observations, we used vertical profiles of temperature and/or geopotential heights from 2001-2008 CHAMP and 2006-2011 COSMIC occultation. GCM trends of the response patterns to the external forcings of respective climate variables were extracted from CMIP 5 GCM runs under representative concentration pathways (RCP) 8.5 and historical climate scenarios, for the same period. Natural variability was calculated using CMIP 5 GCM runs under preindustrial control scenario. The GPS RO data was downloaded from CDAAC website, GCM CMIP 5 data was obtained from Earth System Grid web page. We used optimal fingerprinting method which is generalized multivariate regression adjusted for climate change detection studies. Optimal fingerprinting allows estimating of the climate signal separately from natural climate variability. Following this methodology we applied Empirical Orthogonal Functions to filter observed and modeled data in order to decrease impact of natural variability and maximize the signal to noise ratio. Temperature and geopotential height trends in the simulated and observed climate datasets show similar features of warming of the upper troposphere and cooling of the lower stratosphere in the tropics region. Using optimal fingerprinting we found that the anthropogenic signal emerges from natural variability in GPS RO temperature

  11. On the geometric properties of Cesàro spaces

    NASA Astrophysics Data System (ADS)

    Astashkin, Sergey V.

    2012-04-01

    It is proved that the Cesàro space \\operatorname{Ces}_{p} \\lbrack 0,1 \\rbrack , 1\\le p<\\infty, contains a complemented subspace isomorphic to l^q if and only if either q=1 or q=p. A class of subspaces of this space that contain complemented copies of the space l^p is distinguished. Bibliography: 16 titles.

  12. THE MASS OF CoRoT-7b

    SciTech Connect

    Hatzes, Artie P.; Wuchterl, Guenther; Fridlund, Malcolm; Gandolfi, Davide; Nachmani, Gil; Mazeh, Tsevi; Valencia, Diana; Hebrard, Guillaume; Borde, Pascal; Carone, Ludmila; Paetzold, Martin; Udry, Stephane; Bouchy, Francois; Deleuil, Magali; Moutou, Claire; Barge, Pierre; Deeg, Hans; Tingley, Brandon; Dvorak, Rudolf; Ferraz-Mello, Sylvio E-mail: malcolm.fridlund@esa.int; and others

    2011-12-10

    The mass of CoRoT-7b, the first transiting super-Earth exoplanet, is still a subject of debate. A wide range of masses have been reported in the literature ranging from as high as 8 M{sub Circled-Plus} to as low as 2.3 M{sub Circled-Plus }. This range in mass is largely due to the activity level of the star that contributes a significant amount of radial velocity (RV) 'jitter' and how the various methods correct this jitter. Although most mass determinations give a density consistent with a rocky planet, the lower value permits a bulk composition that can be up to 50% water. We present an analysis of the CoRoT-7b RV measurements that uses very few and simple assumptions in treating the activity signal. By analyzing those RV data for which multiple measurements were made in a given night, we remove the activity related RV contribution without any a priori model. We argue that the contribution of activity to the final RV curve is negligible and that the K-amplitude due to the planet is well constrained. This yields a mass of 7.42 {+-} 1.21 M{sub Circled-Plus} and a mean density of {rho} = 10.4 {+-} 1.8 gm cm{sup -3}. CoRoT-7b is similar in mass and radius to the second rocky planet to be discovered, Kepler-10b, and within the errors they have identical bulk densities-they are virtual twins. These bulk densities lie close to the density-radius relationship for terrestrial planets similar to what is seen for Mercury. CoRoT-7b and Kepler-10b may have an internal structure more like Mercury than the Earth.

  13. High performance RO membranes for desalination and wastewater reclamation and their operation results.

    PubMed

    Henmi, M; Fusaoka, Y; Tomioka, H; Kurihara, M

    2010-01-01

    Reverse osmosis (RO) membrane is one of the most powerful tools for solving the global water crisis, and is used in a variety of water treatment scenes such as drinking water purification, waste-water treatment, boiler feed water production, ultra pure water production for semiconductor industry, etc. The desired performance of RO membrane varies according to quality of feed water being treated, and Toray has been developing RO membranes with suitable characteristic for each operating condition. RO membranes for seawater desalination and wastewater reclamation are especially regarded as most promising targets. Recently, high boron removal and energy saving RO membrane for seawater desalination and low fouling RO membrane for wastewater reclamation have been developed. In this paper, the prospect of attaining these renovative RO membrane, and furthermore, job references will be discussed.

  14. Discoveries in the Atmospheres of roAp Stars

    NASA Astrophysics Data System (ADS)

    Kurtz, D. W.; Freyhammer, L. M.; Elkin, V. G.; Mathys, G.

    2007-11-01

    We have obtained a large amount of data on over 40 roAp stars and potential roAp stars with the Ultraviolet and Visual Echelle Spectrograph (UVES) on the VLT with time resolution typically around 1 min and radial velocity precision as high as 1 m s-1. Abundance stratification caused by atomic diffusion in the presence of strong global magnetic fields gives promise of three-dimensional maps of the pulsation amplitude and phase, and of the abundance distributions of many ions that may provide the strongest observational tests of atomic diffusion theory. Studies of individual spectral lines and of line profile variability sample the observable atmospheres of roAp stars from continuum optical depth τ5000~1 to as high as τ5000~10-5, revealing fascinating new pulsational behaviour not observed in other types of pulsating stars, including, inter alia, line profile variability in rare earth elements lines interpreted by as evidence for shock waves in the high atmosphere of these stars, an intriguing range of line bisector shapes, and a new pulsational diagnostic for resolved Zeeman components for the most strongly magnetic stars.

  15. Sensitization by SR-2508 plus Ro 03-8799

    SciTech Connect

    Stone, H.B.; Luu, Y.H.; Lam, K.N.

    1986-07-01

    The primary toxicity of Ro 03-8799 is a central nervous system toxicity, whereas that of SR-2508 is a peripheral neuropathy. The feasibility of reducing overall toxicity while maintaining maximal radiosensitization by using the two sensitizers together was tested. The LD50/2 of Ro 03-8799 was 0.68 mg/g body wt (mg/gbw) after intravenous (i.v.) administration, and that of SR-2508 was 4.4 mg/gbw after i.v. administration. When both drugs were given together in equitoxic proportions, the LD50/2 was 0.45 mg of Ro 03-8799 plus 2.9 mg of SR-2508/gbw. These doses are 66% of the respective LD50/2 values of the drugs when given separately. Radiosensitization was evaluated using in vivo-in vitro assays with EMT6/SF tumors in BALB/c mice. At drug doses between 10 and 60% of the LD50/2, sensitization was generally maximal and similar to that from misonidazole, but there was less sensitization below this dose, both with the drugs given separately and together. If chronic toxicities of these drugs overlap as do the acute toxicities there will be little or no additional benefit from using these drugs in combination, compared to using them separately.

  16. Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface*

    PubMed Central

    Espinosa, Alexander; Hennig, Janosch; Ambrosi, Aurélie; Anandapadmanaban, Madhanagopal; Abelius, Martina Sandberg; Sheng, Yi; Nyberg, Filippa; Arrowsmith, Cheryl H.; Sunnerhagen, Maria; Wahren-Herlenius, Marie

    2011-01-01

    Ro52 (TRIM21) is an E3 ligase of the tripartite motif family that negatively regulates proinflammatory cytokine production by ubiquitinating transcription factors of the interferon regulatory factor family. Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52. To address this question, the requirements for Ro52 E3 ligase activity were first analyzed in detail. Scanning a panel of E2 ubiquitin-conjugating enzymes, we found that UBE2D1–4 and UBE2E1–2 supported the E3 ligase activity of Ro52 and that the E3 ligase activity of Ro52 was dependent on its RING domain. We also found that the N-terminal extensions in the class III E2 enzymes affected their interaction with Ro52. Although the N-terminal extension in UBE2E3 made this E2 enzyme unable to function together with Ro52, the N-terminal extensions in UBE2E1 and UBE2E2 allowed for a functional interaction with Ro52. Anti-Ro52-positive patient sera and affinity-purified anti-RING domain autoantibodies inhibited the E3 activity of Ro52 in ubiquitination assays. Using NMR, limited proteolysis, ELISA, and Ro52 mutants, we mapped the interactions between Ro52, UBE2E1, and anti-Ro52 autoantibodies. We found that anti-Ro52 autoantibodies inhibited the E3 ligase activity of Ro52 by sterically blocking the E2/E3 interaction between Ro52 and UBE2E1. Our data suggest that anti-Ro52 autoantibodies binding the RING domain of Ro52 may be actively involved in the pathogenesis of rheumatic autoimmune disease by inhibiting Ro52-mediated ubiquitination. PMID:21862588

  17. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    SciTech Connect

    Jauharoh, Siti Nur Aisyah; Saegusa, Jun; Sugimoto, Takeshi; Ardianto, Bambang; Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo; Tokuno, Osamu; Nakamachi, Yuji; Kumagai, Shunichi; Kawano, Seiji

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

  18. Anti-SLA/LP alone or in combination with anti-Ro52 and fine specificity of anti-Ro52 antibodies in patients with autoimmune hepatitis.

    PubMed

    Zachou, Kalliopi; Gampeta, Stella; Gatselis, Nikolaos K; Oikonomou, Katerina; Goulis, John; Manoussakis, Menelaos N; Renaudineau, Yves; Bogdanos, Dimitrios P; Dalekos, George N

    2015-02-01

    Antibodies (Abs) to soluble liver antigen/liver pancreas (anti-SLA/LP) are considered markers of worse prognosis and outcome in patients with autoimmune hepatitis (AIH) although this assumption has recently been attributed to their frequent co-expression with Abs against Ro52 (anti-Ro52). To assess the clinical significance of anti-SLA/LP Abs alone or in combination with anti-Ro52 in AIH patients and determine the immunodominant Ro52 epitopes according to the anti-SLA/LP status. Twenty-three anti-SLA/LP-positive and 106 anti-SLA/LP-negative AIH patients were included. Anti-SLA/LP were determined by ELISA using recombinant antigen, and confirmed by immunoblot using cytosolic rat liver fraction or HuH-7 extract. Anti-Ro52 Abs were determined by ELISA using recombinant antigen. Epitope mapping was assessed by ELISA using overlapping peptides covering the whole Ro52 protein in 26 AIH patients and 12 patients with Sjögren's syndrome. Anti-SLA/LP positivity was not associated with the clinical, laboratory or histological characteristics of AIH patients. Treatment response, corticosteroid withdrawal, relapse after stopping treatment and outcome, were not associated with the presence of anti-SLA/LP, anti-Ro52 or double reactivity. Moreover, Ro52 epitope mapping revealed new epitopes unique for AIH and independent from anti-SLA/LP positivity. Neither anti-SLA/LP nor anti-Ro52 Abs or their combination could specify a distinct group of AIH patients in terms of clinical characteristics, treatment response and outcome. Further studies are needed to clarify whether the newly discovered immunodominant epitopes of Ro52 antigen which were associated specifically with AIH have any clinical or pathogenetic significance in AIH. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. The San Juan Delta, Colombia: tides, circulations, and salt dispersion

    NASA Astrophysics Data System (ADS)

    Restrepo, Juan D.; Kjerfve, Björn

    2002-05-01

    The San Juan River delta (Colombia) with an area of 800 km 2 is the largest delta environment on the Pacific coast of South America. It consists of active distributaries maintained by an average discharge of 2500 m 3 s -1, is tide dominated, and has relatively narrow estuarine mixing zones <17 km wide and typically ˜7 km wide. Water level and current time series in two distributary mouths indicate that the tide is semidiurnal with a form number 0.1-0.2 and a mean range of 3 m. Processes at tidal frequencies explain 75-95% of the water level variability with the remaining low-frequency variability attributed to meteorological forcing and river processes. The tidal phase for the main diurnal and semidiurnal constituents progress from north to south along the coast. Only the southernmost distributary experiences significant tidal asymmetry as a result of strong river discharge and shallow depths. In the northernmost distributary, shallow water constituents are insignificant. Tidal currents were more semidiurnal than the water level, with form number 0.09-0.13. Tidal ellipses indicated that currents were aligned with the channels and mean amplitudes <1 m s -1. In the delta distributaries, circulation modes varied from seaward flow at all depths during intermediate runoff conditions to gravitational circulation during rising and high discharge periods. In San Juan and Chavica distributaries, the currents were ebb-directed, while in Charambirá they were flood-directed. The circulation appears to be controlled by the morphology of the distributaries, which were weakly stratified and only sometimes moderately stratified. The net salt transport was directed seaward in San Juan and Charambirá, and landward at Chavica, indicating an imbalance in the salt budget, and signifying non-steady state behavior. The net longitudinal salt flux in the San Juan delta is largely a balance between ebb-directed advective flux, and flood-directed tidal sloshing. Along the distributary

  20. Arsenic contamination of natural waters in San Juan and La Pampa, Argentina.

    PubMed

    O'Reilly, J; Watts, M J; Shaw, R A; Marcilla, A L; Ward, N I

    2010-12-01

    Arsenic (As) speciation in surface and groundwater from two provinces in Argentina (San Juan and La Pampa) was investigated using solid phase extraction (SPE) cartridge methodology with comparison to total arsenic concentrations. A third province, Río Negro, was used as a control to the study. Strong cation exchange (SCX) and strong anion exchange (SAX) cartridges were utilised in series for the separation and preservation of arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MA(V)) and dimethylarsinic acid (DMA(V)). Samples were collected from a range of water outlets (rivers/streams, wells, untreated domestic taps, well water treatment works) to assess the relationship between total arsenic and arsenic species, water type and water parameters (pH, conductivity and total dissolved solids, TDS). Analysis of the waters for arsenic (total and species) was performed by inductively coupled plasma mass spectrometry (ICP-MS) in collision cell mode. Total arsenic concentrations in the surface and groundwater from Encon and the San José de Jáchal region of San Juan (north-west Argentina within the Cuyo region) ranged from 9 to 357 μg l(-1) As. Groundwater from Eduardo Castex (EC) and Ingeniero Luiggi (LU) in La Pampa (central Argentina within the Chaco-Pampean Plain) ranged from 3 to 1326 μg l(-1) As. The pH range for the provinces of San Juan (7.2-9.7) and La Pampa (7.0-9.9) are in agreement with other published literature. The highest total arsenic concentrations were found in La Pampa well waters (both rural farms and pre-treated urban sources), particularly where there was high pH (typically > 8.2), conductivity (>2,600 μS cm(-1)) and TDS (>1,400 mg l(-1)). Reverse osmosis (RO) treatment of well waters in La Pampa for domestic drinking water in EC and LU significantly reduced total arsenic concentrations from a range of 216-224 μg l(-1) As to 0.3-0.8 μg l(-1) As. Arsenic species for both provinces were predominantly As(III) and As(V). As

  1. Juan Gabriel and audience interpretation. cultural impressions of effeminacy and sexuality in Mexico.

    PubMed

    Sowards, S K

    2000-01-01

    Juan Gabriel's purported effeminacy and sexuality have made him a controversial subject in Mexico, but still loved by fans. Juan Gabriel, by trying to gain acceptance into Mexican society, has become part of a hybrid culture, between the feminine/masculine and homosexual/bisexual/heterosexual groups. This study focuses on interviews with 20 participants who discuss Juan Gabriel's popularity and sexuality. The findings of the study indicate that Juan Gabriel may be considered by his fans to be effeminate, and consequently homosexual. Even though homophobia is widespread in Mexico, Juan Gabriel's fans tend to ignore or exoticize his sexuality, thus affording his success. It is also possible that Juan Gabriel, consciously or not, uses his controversial sexuality as a way to generate popular interest.

  2. Dispersion and nonlinear effects in OFDM-RoF system

    NASA Astrophysics Data System (ADS)

    Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

    2010-08-01

    The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

  3. Potential prodrugs of 6-acetylmethylenepenicillanic acid (Ro 15-1903).

    PubMed

    Adam, S; Then, R; Angehrn, P

    1986-06-01

    The synthesis and biological activities of a series of non-classical penicillins are described. These compounds were synthesized by treating the pivaloyloxymethyl ester of 6-acetylmethylenepenicillanic acid (Ro 15-1903) with various nucleophiles. They were found to be less active against the beta-lactamases from Proteus vulgaris 1028, Escherichia coli 1024, Klebsiella pneumoniae NCTC 418 and E. coli RTEM than the parent compound. Nevertheless, synergy with ampicillin against whole bacterial cells producing beta-lactamases was evident, although the single compounds did not exhibit antibacterial properties. With the compounds 2a and 2b, synergistic interaction with ampicillin could also be demonstrated in mice.

  4. Arrhythmogenic effects of anti-Ro/SSA antibodies on the adult heart: more than expected?

    PubMed

    Lazzerini, Pietro Enea; Capecchi, Pier Leopoldo; Acampa, Maurizio; Selvi, Enrico; Guideri, Francesca; Bisogno, Stefania; Rossi, Pier Carlo; Galeazzi, Mauro; Pasini, Franco Laghi

    2009-09-01

    The arrhythmogenicity of anti-Ro/SSA antibodies for the foetal heart and their crucial role in the development of congenital heart block is now well established, representing a paradigmatic model of passively acquired autoimmunity. Recently, intriguing data suggest that also the adult heart may represent a possible target of anti-Ro/SSA antibody-mediated autoimmune injury. The prolongation of the QTc interval, possibly resulting from a direct inhibitory interaction between the anti-Ro/SSA antibodies and the potassium current I(Kr) in the heart seems the abnormality more frequently observed in adults with anti-Ro/SSA-positive CTD. Although the possibility that anti-Ro/SSA positivity may be considered a risk factor for arrhythmic sudden death in adults has not been demonstrated as yet, preliminary data suggest a relationship among anti-Ro/SSA antibodies, QTc prolongation, and the prevalence of ventricular arrhythmias, also life threatening, in adult patients.

  5. Mineralogy from Cores in Prospect Gulch, San Juan County, Colorado

    USGS Publications Warehouse

    Bove, Dana J.; Johnson, Raymond H.; Yager, Douglas B.

    2007-01-01

    In the late nineteenth century, San Juan County, Colorado, was the center of a metal mining boom in the San Juan Mountains. Although most mining activity ceased by the 1990s, the effects of historical mining continue to contribute metals to ground water and surface water. Previous research by the U.S. Geological Survey identified ground-water discharge as a significant pathway for the loading of metals to surface water from both acid-mine drainage and acid-rock drainage. In an effort to understand the ground-water flow system in the upper Animas River watershed, Prospect Gulch was selected for further study because of the amount of previous data provided in and around that particular watershed. In support of this ground-water research effort, data was collected from drill core, which included: (1) detailed descriptions of the subsurface geology and hydrothermal alteration patterns, (2) depth of sulfide oxidation, and (3) quantitative mineralogy.

  6. Oral anatomy in the sixteenth century: Juan Valverde de Amusco.

    PubMed

    López-Valverde, A; Gómez de Diego, R; De Vicente, J

    2013-08-01

    In 1554 Juan Valverde de Amusco, a Spanish anatomist, wrote the History of the composition of the human body, a complete anatomical treatise that took as its model the Vesalius school of thought (La fábrica of Vesalius). Considered one of the most complete anatomical treatises of the Renaissance and one of the most widely read books of the sixteenth century, it was translated into four languages in its day. The first chapter, devoted to bones, provides a meticulously detailed analysis of the bones of the facial structures and of the teeth, their supporting structures, vascularisation and innervation. Juan Valverde de Amusco even describes techniques for reducing mandibular luxations. Even with the imprecise observations typical of the time the treatise must be considered an exceptional document.

  7. 33 CFR 110.74c - Bahia de San Juan, PR.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward...

  8. Teaching and Communicating Astronomy at Rey Juan Carlos University

    NASA Astrophysics Data System (ADS)

    Hernán-Obispo, M.; Serrano, A.; Aguirre, J.; Martín, P. San

    We present our activities of popularization of Astronomy at Rey Juan Carlos University in Madrid, especially our 30-h workshop for people older than 55 (University for the Elderly) held since the academic year 2002/2003. Our course aims to introduce the basic topics on Astronomy to a group of motivated students who, in most cases, were not able to complete their education in their youth due to the historical environment of Spain in the middle of the twentieth century.

  9. San Juan Bay Estuary watershed urban forest inventory

    Treesearch

    Thomas J. Brandeis; Francisco J. Escobedo; Christina L. Staudhammer; David J. Nowak; Wayne C. Zipperer

    2014-01-01

    We present information on the urban forests and land uses within the watershed of Puerto Rico’s 21 658-ha San Juan Bay Estuary based on urban forest inventories undertaken in 2001 and 2011. We found 2548 ha of mangrove and subtropical moist secondary forests covering 11.8 percent of the total watershed area in 2011. Red, black, and white mangroves (Rhizophora...

  10. Anti-Ro/SSA antibodies in rheumatoid arthritis: clinical and immunologic associations.

    PubMed

    Cavazzana, I; Franceschini, F; Quinzanini, M; Manera, C; Del Papa, N; Maglione, W; Comina, D; Radice, A; Sinico, R A; Cattaneo, R

    2006-01-01

    To assess the prevalence of anti-Ro/SSA in RA and to analyse clinical and serological features of anti-Ro/SSA positive patients with RA. 195 consecutive patients affected by RA were studied by counterimmunoelectrophoresis and ELISA for the detection of anti-Ro/SSA antibodies. Anti-Ro were found in 12 patients, with a prevalence of 6%. These 12 patients were pooled with other 15 patients known to have anti-Ro/SSA antibodies and RA, in order to evaluate their clinical and laboratory features. Anti-Ro positive patients showed a common pattern of joint involvement at onset and a comparable progression of disease compared to anti-Ro negative subjects. In addition, extra-articular manifestations (such as xerophthalmia, xerostomia, scleritis, oral ulcers and amyloidosis) and peculiar autoantibody profile (hypergammaglobulinemia, anti-dsDNA and AMA) were found significantly associated to anti-Ro/SSA positivity. Even though DMARDs withdrawals were more frequently detected in anti-Ro/SSA patients, especially when using gold salts, no statistical difference between the two groups was detected. In addition, anti-TNFalpha treatment did not cause further progression of autoimmunity neither on laboratory nor on clinical ground. Anti-Ro/SSA can be detected in about 6% of patients affected by RA. These patients presented a peculiar clinical picture characterised by extra-articular manifestations some of which are known to be anti-Ro/SSA correlated, while others are more disease-specific (amyloidosis, episcleritis). Anti-Ro/SSA are significantly associated with other autoantibodies not specific for RA such as anti-dsDNA and AMA. Treatment with anti-TNF drugs did not cause further progression of autoimmunity neither on laboratory nor on clinical ground.

  11. Carbon storage and greenhouse gas fluxes in the San Juan ...

    EPA Pesticide Factsheets

    Mangrove systems are known carbon (C) and greenhouse gas (GHG) sinks, but this function may be affected by global change drivers that include (but are not limited to) eutrophication, climate change, species composition shifts, and hydrological changes. In Puerto Rico’s San Juan Bay Estuary, mangrove wetlands are characterized by anthropogenic impacts, particularly tidal restriction due to infilling of the Martin Pena Canal and eutrophication. The objective of our research is to measure carbon sequestration and carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes in the San Juan Bay Estuary to understand the sustainability and role in global climate of this urban mangrove ecosystem. Cores for C sequestration measurements were collected and GHG fluxes were measured during rainy and dry seasons at 5 sites along a gradient of development and nitrogen loading in the San Juan Bay Estuary. At each site, paired GHG flux measurements were performed for mangrove wetland soil and estuarine water using static and floating chambers. Our results suggest a positive relationship between urban development and CH4 and N2O emissions, and demonstrate that in this system, estuarine waters are a major methane source. In addition to providing characterization of GHG fluxes in an urban subtropical estuary, these data provide a baseline against which future states of the estuary (after planned hydrological restoration has been implemented) may be compared. In Puer

  12. Carbon storage and greenhouse gas fluxes in the San Juan ...

    EPA Pesticide Factsheets

    Mangrove systems are known carbon (C) and greenhouse gas (GHG) sinks, but this function may be affected by global change drivers that include (but are not limited to) eutrophication, climate change, species composition shifts, and hydrological changes. In Puerto Rico’s San Juan Bay Estuary, mangrove wetlands are characterized by anthropogenic impacts, particularly tidal restriction due to infilling of the Martin Pena Canal and eutrophication. The objective of our research is to measure carbon sequestration and carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes in the San Juan Bay Estuary to understand the sustainability and role in global climate of this urban mangrove ecosystem. Cores for C sequestration measurements were collected and GHG fluxes were measured during rainy and dry seasons at 5 sites along a gradient of development and nitrogen loading in the San Juan Bay Estuary. At each site, paired GHG flux measurements were performed for mangrove wetland soil and estuarine water using static and floating chambers. Our results suggest a positive relationship between urban development and CH4 and N2O emissions, and demonstrate that in this system, estuarine waters are a major methane source. In addition to providing characterization of GHG fluxes in an urban subtropical estuary, these data provide a baseline against which future states of the estuary (after planned hydrological restoration has been implemented) may be compared. Thi

  13. Experimental Study of Advanced Treatment of Coking Wastewater Using MBR-RO Combined Process

    NASA Astrophysics Data System (ADS)

    Zhang, Lei; Hwang, Jiannyang; Leng, Ting; Xue, Gaifeng; Chang, Hongbing

    A membrane bioreactor-reverse osmosis (MBR-RO) combined process was used for advanced treatment of coking wastewater from secondary biological treatment. MBR and RO units' treatment efficiency for the pollution removal were conducted, and effects of raw water conductivity and trans-membrane pressure on water yield and desalination rate in RO unit were investigated in detail. The experimental results proved that MBR-RO combined process ran steadily with good treatment effect, which could obtain stable effluent water quality and met the requirement of "Design Criterion of the Industrial Circulating Cooling Water Treatment" (GB 50050-2007).

  14. Conversion of tunneled hemodialysis catheter into HeRO device can provide immediate access for hemodialysis.

    PubMed

    Vasquez, Julio C; DeLaRosa, Jacob; Rahim, Fahim; Rahim, Naeem

    2010-11-01

    Patients with central venous occlusion who are ''tunneled catheter dependent'' are a challenge for hemodialysis access. A relatively new option for them is the hemodialysis reliable outflow (HeRO) device that can be totally implanted subcutaneously. However, patients still require a tunneled hemodialysis catheter that is used until the HeRO device is mature, 4 to 6 weeks later. Here, we describe a conversion of an existing tunneled hemodialysis catheter into a HeRO device, which was combined with a ''self-sealing'' Flixene graft. This allowed almost immediate use of the HeRO device without the need for placement of a catheter.

  15. San Juan sag: A newly discovered basin beneath San Juan volcanic field of south-central Colorado

    SciTech Connect

    Gries, R.R.

    1989-09-01

    The San Juan sag is a Laramide foreland basin formerly adjacent to and west of the Laramide northern Sangre de Cristo/San Luis highland. Wrench faulting (Eocene ) and rifting (Oligocene and Miocene) split this bounding uplift and formed the San Luis basin adjacent to and east of the sag. Volcanism concealed the San Juan sag with over 10,000 ft of intermediate volcanic deposits, and its presence remained in doubt until oil in the volcanic rocks encouraged exploration for the underlying sedimentary rocks. Drilling through the volcanic field since 1984 has revealed the presence of Paleocene and Eocene( ) clastic sediments, the Cretaceous Lewis, Mancos, and Dakota formations, and the Jurassic Morrison and Junction Creek formations. Additionally, oil and gas shows abound, and minor production has been established. Exploratory drilling and geophysical acquisitions have helped to define basin geometry, reservoir rocks, source rocks, and maturation and burial history.

  16. Removal of organic contaminants by RO and NF membranes

    NASA Technical Reports Server (NTRS)

    Yoon, Yeomin; Lueptow, Richard M.

    2005-01-01

    Rejection characteristics of organic and inorganic compounds were examined for six reverse osmosis (RO) membranes and two nanofiltration (NF) membranes that are commercially available. A batch stirred-cell was employed to determine the membrane flux and the solute rejection for solutions at various concentrations and different pH conditions. The results show that for ionic solutes the degree of separation is influenced mainly by electrostatic exclusion, while for organic solutes the removal depends mainly upon the solute radius and molecular structure. In order to provide a better understanding of rejection mechanisms for the RO and NF membranes, the ratio of solute radius (r(i,s)) to effective membrane pore radius (r(p)) was employed to compare rejections. An empirical relation for the dependence of the rejection of organic compounds on the ratio r(i,s)/r(p) is presented. The rejection for organic compounds is over 75% when r(i,s)/r(p) is greater than 0.8. In addition, the rejection of organic compounds is examined using the extended Nernst-Planck equation coupled with a steric hindrance model. The transport of organic solutes is controlled mainly by diffusion for the compounds that have a high r(i,s)/r(p) ratio, while convection is dominant for compounds that have a small r(i,s)/r(p) ratio. c2005 Elsevier B.V. All rights reserved.

  17. Removal of organic contaminants by RO and NF membranes

    NASA Technical Reports Server (NTRS)

    Yoon, Yeomin; Lueptow, Richard M.

    2005-01-01

    Rejection characteristics of organic and inorganic compounds were examined for six reverse osmosis (RO) membranes and two nanofiltration (NF) membranes that are commercially available. A batch stirred-cell was employed to determine the membrane flux and the solute rejection for solutions at various concentrations and different pH conditions. The results show that for ionic solutes the degree of separation is influenced mainly by electrostatic exclusion, while for organic solutes the removal depends mainly upon the solute radius and molecular structure. In order to provide a better understanding of rejection mechanisms for the RO and NF membranes, the ratio of solute radius (r(i,s)) to effective membrane pore radius (r(p)) was employed to compare rejections. An empirical relation for the dependence of the rejection of organic compounds on the ratio r(i,s)/r(p) is presented. The rejection for organic compounds is over 75% when r(i,s)/r(p) is greater than 0.8. In addition, the rejection of organic compounds is examined using the extended Nernst-Planck equation coupled with a steric hindrance model. The transport of organic solutes is controlled mainly by diffusion for the compounds that have a high r(i,s)/r(p) ratio, while convection is dominant for compounds that have a small r(i,s)/r(p) ratio. c2005 Elsevier B.V. All rights reserved.

  18. The CoRoT Mission - Status and Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fridlund, M.

    2007-08-01

    The CoRoT (Convection, Rotation and planetary Transits) space mission is the first dedicated space mission designed to search for exo-planets akin to our own. It is a joint effort by France, Austria Belgium, Brazil, Germany, Spain and the European Space Agency. It is specifically designed to search for exo-planets much smaller than hitherto discovered. It was launched in December 2006 on a mission lasting not less than 3 years. Verification and first operations have proven the mission to superceed all expectations. This is of course most relevant in the fact that planets as small as our own Earth are detectable. In this presentation we describe the experiences of the first 6 mo0nths of the mission, the actual status of the mission, the supporting ground based program, and what we expect in the near future. After giving examples of data relevant to the topic of this session, we turn to describing the expected impact of the results of CoRoT on future endeavours such as KEPLER, Extremely Large Telescopes (ELT's) and ultimately Darwin.

  19. A New Mapping Function Based on GNSS-RO observations

    NASA Astrophysics Data System (ADS)

    Benedetto, Catia; Rosciano, Elisa; Vespe, Francesco; Vizziello, Giuseppe

    2015-04-01

    The coordinates of a static Global Navigation Satellite System (GNSS) station placed on the ground are estimated together with the delay suffered by the incoming satellite signals through the atmosphere. The tropospheric delay (TD) is shaped as the product of the zenith delay (ZTD) times a mapping function (MF) depending on the sine of elevation angles. In processing chain, ZTD is just estimated together with the coordinates; while the MF is modelled apart, in an independent way, by using atmospheric profiles retrieved with balloon observations ( RAOB) as done for the Niell MF (1996) or provided by climate or Numerical Weather Prediction (NWP) models as in the Vienna MFs. The several space missions devoted to GNSS-RO (e.g. COSMIC-FORMOSAT, METOP, CHAMP, GRACE end others) are providing a huge amount of data which makes worthwhile to be attempted the reconstruction of a new mapping function based on such kind of data. Thus we have built the "Matera" MF ( MTMF) based just on GNSS-RO observations. The new MTMF will be applied to a network of EUREF GNSS stations in the Mediterranean area. Formal errors and repeatability of ZTD and coordinates estimated with the MTMF will be compared with those achieved applying other MF. In validation activities we plan to use the Bernese software.

  20. CoRoT 101186644: A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H. J.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

    2013-05-01

    We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (mV = 16) candidate revealed an eclipsing binary composed of a late F-type primary (Teff = 6090 ± 200 K) and a low-mass, dense late M-dwarf secondary on an eccentric (e = 0.4) orbit with a period of ~20.7 days. The M-dwarf has a mass of 0.096 ± 0.011 M⊙, and a radius of 0.104-0.006+0.026 R⊙, which possibly makes it the smallest and densest late M-dwarf reported so far. Unlike the claim that theoretical models predict radii that are 5-15% smaller than measured for low-mass stars, this one seems to have a radius that is consistent and might even be below the radius predicted by theoretical models. Based on observations made with the 1-m telescope at the Wise Observatory, Israel, the Swiss 1.2-m Leonhard Euler telescope at La Silla Observatory, Chile, the IAC-80 telescope at the Observatory del Teide, Canarias, Spain, and the 3.6-m telescope at La Silla Observatory (ESO), Chile (program 184.C-0639).

  1. Hydrologic data from wells at or in the vicinity of the San Juan coal mine, San Juan County, New Mexico

    USGS Publications Warehouse

    Stewart, Anne M.; Thomas, Nicole

    2015-01-01

    In 2010, in cooperation with the Mining and Minerals Division (MMD) of the State of New Mexico Energy, Minerals and Natural Resources Department, the U.S. Geological Survey (USGS) initiated a 4-year assessment of hydrologic conditions at the San Juan coal mine (SJCM), located about 14 miles west-northwest of the city of Farmington, San Juan County, New Mexico. The mine produces coal for power generation at the adjacent San Juan Generating Station (SJGS) and stores coal-combustion byproducts from the SJGS in mined-out surface-mining pits. The purpose of the hydrologic assessment is to identify groundwater flow paths away from SJCM coal-combustion-byproduct storage sites that might allow metals that may be leached from coal-combustion byproducts to eventually reach wells or streams after regional dewatering ceases and groundwater recovers to predevelopment levels. The hydrologic assessment, undertaken between 2010 and 2013, included compilation of existing data. The purpose of this report is to present data that were acquired and compiled by the USGS for the SJCM hydrologic assessment.

  2. Anti-SSA/Ro52 autoantibodies in scleroderma: results of an observational, cross-sectional study.

    PubMed

    Sánchez-Montalvá, A; Fernández-Luque, A; Simeón, C P; Fonollosa-Plà, V; Marín, A; Guillén, A; Vilardell, M

    2014-01-01

    To date, the diagnostic utility of anti-SSA/Ro52 autoantibodies in scleroderma and the association of them with certain clinical manifestations, particularly inflammatory myositis, are still controversial. This paper aims to assess the correlation between the presence of anti-SSA/Ro52 antibodies and the demographic, clinical and prognosis characteristics of patients with systemic sclerosis (SSc). This is a retrospective, cross-sectional and observational study in patients with SSc. Baseline demographic and clinical characteristics were recorded. Presence of anti-SSA/Ro52, anti-SSA/Ro, anti-SSB/La, snRNP/Sm, anti-centromere, anti-Scl-70 and anti-PM-Scl were analysed by immunoblot, and antinuclear antibodies (ANA) by indirect immunofluorescence. Statistical analysis was performed with PASW Statics 18 software. A total of 132 consecutive patients with analysis of anti-SSA/Ro52 antibodies were selected from a Spanish cohort of 408 patients with SSc, 87.1% of them being women. About half of patients had the limited form (51.5%), followed by diffused form (18.9%), sclerosis sine scleroderma (22.7%), and pre-scleroderma (6.8%). Prevalence of anti-SSA/Ro52 was 35.6%. No association between anti-SSA/Ro52 and clinical manifestations was found, while detection of anti-SSA/Ro52 was significantly associated with the presence of anti-Ro. The results of our study show that anti-SSA/Ro52 antibodies are often found in SSc patients. No clinical manifestations, including inflammatory myopathy, were related with anti-SSA/Ro antibodies.

  3. Voice disorders in the Metropolitan Area of San Juan, Puerto Rico: profiles of occupational groups.

    PubMed

    Villanueva-Reyes, Albert

    2011-01-01

    Approximately 28,000,000 workers in the United States experience voice problems everyday. In general, voice problems are very common, but they are more frequent among certain occupational groups. Descriptive cross-sectional study. We analyzed 129 available records of voice-disordered cases reported during the period of 2000-2005 from the Corporación del Fondo del Seguro del Estado in the Metropolitan Areas of Puerto Rico of Bayamón, San Juan, and Carolina. The following variables were studied: sex, age, occupation, possible job hazards, diagnosis, and type of treatment. Measures of central tendency, including percentage frequencies, were used. The findings revealed that 81% of all the cases of voice disorders available during the study period were females. The average age at diagnosis for different voice disorders was 42 years (± 10 years). Vocal problems were reported with a higher frequency by teachers at the elementary and high school levels (72%). The most common complaints were job-related voice overuse (30%) and excessive dust at the workplace. The most frequent medical diagnoses related to voice disorders were rhynopharyngitis (27%), several types of laryngitis (21%), and laryngopharyngitis (10%). The most frequent treatment modality for laryngeal disease and voice problems was the prescription of medication. The most relevant factor of voice disorders for professional voice users is the vocal overload during their job. It is advisable to implement voice disorder-prevention programs for teachers because of the high rate of vocal dysfunction among these professionals. Copyright © 2011 The Voice Foundation. Published by Mosby, Inc. All rights reserved.

  4. Gas-Phase Ozonolysis of Cycloalkenes: Formation of Highly Oxidized RO2 Radicals and Their Reactions with NO, NO2, SO2, and Other RO2 Radicals.

    PubMed

    Berndt, Torsten; Richters, Stefanie; Kaethner, Ralf; Voigtländer, Jens; Stratmann, Frank; Sipilä, Mikko; Kulmala, Markku; Herrmann, Hartmut

    2015-10-15

    The gas-phase reaction of ozone with C5-C8 cycloalkenes has been investigated in a free-jet flow system at atmospheric pressure and a temperature of 297 ± 1 K. Highly oxidized RO2 radicals bearing at least 5 O atoms in the molecule and their subsequent reaction products were detected in most cases by means of nitrate-CI-APi-TOF mass spectrometry. Starting from a Criegee intermediate after splitting-off an OH-radical, the formation of these RO2 radicals can be explained via an autoxidation mechanism, meaning RO2 isomerization (ROO → QOOH) and subsequently O2 addition (QOOH + O2 → R'OO). Time-dependent RO2 radical measurements concerning the ozonolysis of cyclohexene indicate rate coefficients of the intramolecular H-shifts, ROO → QOOH, higher than 1 s(-1). The total molar yield of highly oxidized products (predominantly RO2 radicals) from C5-C8 cycloalkenes in air is 4.8-6.0% affected with a calibration uncertainty by a factor of about two. For the most abundant RO2 radical from cyclohexene ozonolysis, O,O-C6H7(OOH)2O2 ("O,O" stands for two O atoms arising from the ozone attack), the determination of the rate coefficients of the reaction with NO2, NO, and SO2 yielded (1.6 ± 0.5) × 10(-12), (3.4 ± 0.9) × 10(-11), and <10(-14) cm(3) molecule(-1) s(-1), respectively. The reaction of highly oxidized RO2 radicals with other peroxy radicals (R'O2) leads to detectable accretion products, RO2 + R'O2 → ROOR' + O2, which allows to acquire information on peroxy radicals not directly measurable with the nitrate ionization technique applied here. Additional experiments using acetate as the charger ion confirm conclusively the existence of highly oxidized RO2 radicals and closed-shell products. Other reaction products, detectable with this ionization technique, give a deeper insight in the reaction mechanism of cyclohexene ozonolysis.

  5. The CoRoT transit candidate catalog

    NASA Astrophysics Data System (ADS)

    Aigrain, S.; Deleuil, M.

    2013-09-01

    We present a full catalog of all the candidate transiting planets identified by the CoRoT space mission during its first 5 years of operations, including homogeneously derived transit parameters, validation diagnostics and a summary of the outcome of follow-up observations, where available.The catalog includes confirmed planets, clear false alarms (mainly blended or grazing eclipsing binaries), but also dozens of unconfirmed cases, where the follow-up was either inconclusive (hot stars, fast rotators) or incomplete (owing to limited telescope time and the relatively faint nature of the CoRoT targets). The catalog is intended primarily as a resource for the community, for example as a starting point for completeness and population studies. The candidate detection and selection processes have evolved significantly over the course of the mission. Several teams independently analyse the light curves from each observing run, searching for transits and providing ranked candidate lists, which are subsequently merged and ranked manually. This enables the use of some specialist methods, which are better suited to the detection of only certain types of transits, but makes it difficult to provide an overall assessment of the sensitivity of the mission to transits of different depths and periods. However, we note the transit search methods used by the different teams have gradually converged since launch, and there are now fewer teams actively involved in the transit search, with more overlap between the resulting candidate lists. For each CoRoT observing run, one team member coordinates the selection of candidates for followup, with input from the other team members. The set of criteria used to perform this selection have also evolved over the years, becoming more homogeneous. In particular, the light curve fitting tools used to produce the transit parameters and other diagnostics, which are included in the present catalog, are now routinely used to validate candidates and

  6. Emerging roles for the Ro 60 kDa autoantigen in noncoding RNA metabolism

    PubMed Central

    Sim, Soyeong; Wolin, Sandra L.

    2011-01-01

    All cells contain an enormous variety of ribonucleoprotein complexes that function in diverse processes. Although the mechanisms by which many of these RNPs contribute to cell metabolism are well understood, the roles of others are only now beginning to be revealed. A member of this latter category, the Ro 60 kDa protein and its associated noncoding Y RNAs, was discovered because the protein component is a frequent target of the autoimmune response in patients with the rheumatic diseases systemic lupus erythematosus and Sjögren’s syndrome. Recent studies have shown that Ro is ring-shaped, binds the single-stranded ends of misfolded noncoding RNAs in its central cavity, and may function in noncoding RNA quality control. Although Ro is not present in yeast, many bacterial genomes contain potential Ro orthologs. In the radiation-resistant eubacterium Deinococcus radiodurans, the Ro ortholog functions with exoribonucleases during stress-induced changes in RNA metabolism. Moreover, in both D. radiodurans and animal cells, Ro is involved in the response to multiple types of environmental stress. Finally, Y RNAs can influence the subcellular location of Ro, inhibit access of the central cavity to other RNAs and may also act as binding sites for proteins that influence Ro function. PMID:21823229

  7. endo-Cyclization of unsaturated RO2 radicals from the gas-phase ozonolysis of cyclohexadienes.

    PubMed

    Richters, Stefanie; Pfeifle, Mark; Olzmann, Matthias; Berndt, Torsten

    2017-04-06

    Unsaturated RO2 radicals from the ozonolysis of cyclodienes can readily undergo an endo-cyclization step under atmospheric conditions forming a new ring-containing RO2 radical after further O2 addition. This path represents an extension of the atmospheric autoxidation scheme forming highly oxidized multifunctional organic compounds (HOMs). HOMs play an important role for Earth's organic aerosol burden.

  8. In vitro activity of RO363, a beta1-adrenoceptor selective agonist.

    PubMed Central

    Iakovidis, D.; Malta, E.; McPherson, G. A.; Raper, C.

    1980-01-01

    1 The beta-adrenoceptor stimulant effects of RO363 and (--)-isoprenaline have been compared in a variety of isolated tissue preparations. 2 RO363 is approximately half as potent as (--)-isoprenaline in tissues where actions are due to beta1-receptor activation (guinea-pig atrial and ileal preparations and ventricular strips from the rabbit, rat and guinea-pig. 3 In uterine and lung strip preparations from the guinea-pig, where responses are due to beta2-receptor stimulation. RO363 is 100 to 350 times less active than (--)-isoprenaline and has a low intrinsic activity. 4 In spontaneously contracted tracheal preparations from the guinea-pig, RO363 is a full agonist and is approximately half as potent as (--)-isoprenaline. These effects of RO363 are due to the activation of a population of beta1-receptors in the tissue since RO363 and (--)-isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations. In addition the Kb values for practolol are similar in all these preparations when RO363 is used as the agonist. 5 The results show that RO363 is a potent and highly selective beta1-receptor agonist. PMID:6103722

  9. High Flux, Fouling Resistant Membranes for RO Pretreatment

    DTIC Science & Technology

    2010-07-30

    technology and manufacture a hollow‐fiber  module that may be used for pretreatment to the  reverse   osmosis  unit in the Navy  desalination  system...project objective is to develop low‐maintenance, high‐flux, low‐fouling water filtration modules for  reverse   osmosis  (RO) pre‐treatment in order to... Reverse   Osmosis  unit (NSRO) where  cartridge filters are the pretreatment prior to single pass  reverse   osmosis .  The NSRO system was  designed in the

  10. TU-CD-BRD-00: Incident Learning / RO-ILS

    SciTech Connect

    2015-06-15

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

  11. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY.

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  12. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  13. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  14. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  15. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  16. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Security Zone; San Juan, Puerto Rico. (a) Location. Moving and fixed security zones are established 50... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; San Juan, Puerto Rico. 165.758 Section 165.758 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

  17. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Security Zone; San Juan, Puerto Rico. (a) Location. Moving and fixed security zones are established 50... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; San Juan, Puerto Rico. 165.758 Section 165.758 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

  18. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Security Zone; San Juan, Puerto Rico. (a) Location. Moving and fixed security zones are established 50... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; San Juan, Puerto Rico. 165.758 Section 165.758 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

  19. 33 CFR 165.758 - Security Zone; San Juan, Puerto Rico.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Security Zone; San Juan, Puerto Rico. (a) Location. Moving and fixed security zones are established 50... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; San Juan, Puerto Rico. 165.758 Section 165.758 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...

  20. 78 FR 61958 - San Juan County Historical Society; Notice of Preliminary Determination of A Qualifying Conduit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-08

    ... Energy Regulatory Commission San Juan County Historical Society; Notice of Preliminary Determination of A..., San Juan County Historical Society filed a notice of intent to construct a qualifying conduit... Historical Society, P.O. Box 154, Silverton, CO 81433, Phone No. (970) 387-5488. FERC Contact: Robert...

  1. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  2. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  3. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  4. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY.

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  5. 33 CFR 110.240 - San Juan Harbor, P.R.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Juan Harbor, P.R. 110.240 Section 110.240 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.240 San Juan Harbor, P.R. (a) The anchorage...

  6. 77 FR 61632 - Final Environmental Impact Statement for Cattle Point Road Relocation, San Juan Island National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... bluff erosion that threatens a segment of the Cattle Point Road located in San Juan Island National... terminates on the southeastern tip of San Juan Island, is threatened by coastal erosion at the base of the... erosion continues unabated, the roadway eventually may fail, disrupting vehicular access to these areas...

  7. CHARACTERIZING THE ORGANIC MATTER IN SURFACE SEDIMENTS FROM THE SAN JUAN BAY ESTUARY

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  8. Characterizing the Organic Matter in Surface Sediments from the San Juan Bay Estuary,

    EPA Science Inventory

    The San Juan Bay Estuary (SJBE) is located on the north coast of Puerto Rico and includes the San Juan Bay, San José Lagoon, La Torrecilla Lagoon and Piñones Lagoon, as well as the Martín Peña and the Suárez Canals. The SJBE watershed has the highest...

  9. 78 FR 48185 - Notice of Intent To Contract for Hydroelectric Power Development on the San Juan-Chama Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ..., 4P10000] Notice of Intent To Contract for Hydroelectric Power Development on the San Juan-Chama Project..., select lessee, and contract for hydroelectric power development on the San Juan-Chama Project. SUMMARY... development of hydroelectric power on the San Juan-Chama Project at any or all of the conduit locations...

  10. 75 FR 41819 - Reorganization/Expansion of Foreign-Trade Zone 61 San Juan, Puerto Rico, Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Foreign-Trade Zones Board Reorganization/Expansion of Foreign-Trade Zone 61 San Juan, Puerto Rico, Area...), the Foreign-Trade Zones Board (the Board) adopts the following Order: Whereas, the Puerto Rico Trade... (proposed Sites 14, 15 and 16) in the San Juan, Puerto Rico, area within and adjacent to the San Juan...

  11. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  12. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  13. 33 CFR 167.1302 - In the approaches to the Strait of Juan de Fuca: Southwestern approach.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Southwestern approach. 167.1302 Section 167.1302 Navigation and Navigable Waters....1302 In the approaches to the Strait of Juan de Fuca: Southwestern approach. In the southwestern approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by...

  14. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  15. 33 CFR 167.1301 - In the approaches to the Strait of Juan de Fuca: Western approach.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Western approach. 167.1301 Section 167.1301 Navigation and Navigable Waters COAST....1301 In the approaches to the Strait of Juan de Fuca: Western approach. In the western approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by a line...

  16. 33 CFR 167.1302 - In the approaches to the Strait of Juan de Fuca: Southwestern approach.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Southwestern approach. 167.1302 Section 167.1302 Navigation and Navigable Waters....1302 In the approaches to the Strait of Juan de Fuca: Southwestern approach. In the southwestern approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by...

  17. 33 CFR 167.1315 - In the Strait of Juan de Fuca: Precautionary area “PA.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false In the Strait of Juan de Fuca... Traffic Separation Schemes and Precautionary Areas Pacific West Coast § 167.1315 In the Strait of Juan de Fuca: Precautionary area “PA.” In the Strait of Juan de Fuca, precautionary area “PA” is...

  18. 33 CFR 167.1301 - In the approaches to the Strait of Juan de Fuca: Western approach.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Western approach. 167.1301 Section 167.1301 Navigation and Navigable Waters COAST....1301 In the approaches to the Strait of Juan de Fuca: Western approach. In the western approach to the Strait of Juan de Fuca, the following are established: (a) A separation zone bounded by a line...

  19. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  20. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  1. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  2. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Zone and Captain of the Port Zone. 3.35-25 Section 3.35-25 Navigation and Navigable Waters COAST GUARD... CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection Zone and Captain of the Port Zone. Sector San Juan's office is located in San Juan, PR. The boundaries...

  3. Arrhythmogenicity of Anti-Ro/SSA Antibodies in Patients With Torsades de Pointes.

    PubMed

    Lazzerini, Pietro Enea; Yue, Yuankun; Srivastava, Ujala; Fabris, Frank; Capecchi, Pier Leopoldo; Bertolozzi, Iacopo; Bacarelli, Maria Romana; Morozzi, Gabriella; Acampa, Maurizio; Natale, Mariarita; El-Sherif, Nabil; Galeazzi, Mauro; Laghi-Pasini, Franco; Boutjdir, Mohamed

    2016-04-01

    In patients with autoimmune disease, anti-Ro/SSA antibodies (anti-Ro/SSA) are responsible for a novel autoimmune-associated long-QT syndrome by targeting the hERG potassium channel and inhibiting the related current (IKr). Because anti-Ro/SSA are also present in a significant proportion of healthy subjects and may be associated with torsades de pointes (TdP) arrhythmia, we tested the hypothesis that anti-Ro/SSA may represent a silent risk factor in patients developing TdP. Twenty-five consecutive patients who experienced TdP were prospectively collected independent of ongoing therapies and concomitant diseases. Anti-Ro/SSA were detected by fluoroenzyme immunoassay, immuno-Western blotting, and line-blot immunoassay. Purified IgGs from anti-Ro/SSA-positive and anti-Ro/SSA-negative patients were tested on IKr using HEK293 cells stably expressing the hERG channel. As expected, in TdP patients, many known corrected QT interval-prolonging risk factors were simultaneously present, including hypokalemia that was the most common (52%). Anti-Ro/SSA were present in 60% of the subjects, mostly the anti-Ro/SSA-52-kD subtype detected by immuno-Western blotting only. A history of autoimmune disease was found in only 2 of anti-Ro/SSA-positive patients. Experimental data demonstrated that purified anti-Ro/SSA-positive IgGs significantly inhibited IKr and cross reacted with hERG-channel proteins. Moreover, anti-Ro/SSA-positive sera exhibited high reactivity with a peptide corresponding to the hERG-channel pore-forming region. Anti-Ro/SSA may represent a clinically silent novel risk factor for TdP development via an autoimmune-mediated electrophysiological interference with the hERG channel. We propose that TdP patients may benefit from specific anti-Ro/SSA testing even in the absence of autoimmune diseases as immunomodulating therapies may be effective in shortening corrected QT interval and reducing TdP recurrence risk. © 2016 American Heart Association, Inc.

  4. Transiting exoplanets from the CoRoT space mission. XXVI. CoRoT-24: a transiting multiplanet system

    NASA Astrophysics Data System (ADS)

    Alonso, R.; Moutou, C.; Endl, M.; Almenara, J.-M.; Guenther, E. W.; Deleuil, M.; Hatzes, A.; Aigrain, S.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cavarroc, C.; Cabrera, J.; Carpano, S.; Csizmadia, Sz.; Cochran, W. D.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Fruth, T.; Gandolfi, D.; Gillon, M.; Grziwa, S.; Guillot, T.; Hébrard, G.; Jorda, L.; Léger, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ofir, A.; Ollivier, M.; Pasternacki, T.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tadeu dos Santos, M.; Tingley, B.; Titz-Weider, R.; Weingrill, J.; Wuchterl, G.

    2014-07-01

    We present the discovery of a candidate multiply transiting system, the first one found in the CoRoT mission. Two transit-like features with periods of 5.11 and 11.76 d are detected in the CoRoT light curve around a main sequence K1V star of r = 15.1. If the features are due to transiting planets around the same star, these would correspond to objects of 3.7 ± 0.4 and 5.0 ± 0.5 R⊕ , respectively. Several radial velocities serve to provide an upper limit of 5.7 M⊕ for the 5.11 d signal and to tentatively measure a mass of 28+11-11 M⊕ for the object transiting with a 11.76 d period. These measurements imply low density objects, with a significant gaseous envelope. The detailed analysis of the photometric and spectroscopic data serves to estimate the probability that the observations are caused by transiting Neptune-sized planets as much as over 26 times higher than a blend scenario involving only one transiting planet and as much as over 900 times higher than a scenario involving two blends and no planets. The radial velocities show a long-term modulation that might be attributed to a 1.5 MJup planet orbiting at 1.8 AU from the host, but more data are required to determine the precise orbital parameters of this companion. The CoRoT space mission, launched on 27 December 2006, has been developed and is operated by the CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Program), Germany, and Spain. Some of the observations were made with the HARPS spectrograph at ESO La Silla Observatory (184.C-0639) and with the HIRES spectrograph at the Keck Telescope (N035Hr, N143Hr 260 and N095Hr). Partly based on observations obtained at ESO Paranal Observatory, Chile (086.C-0235(A) and B).Tables 2-4 and Fig. 12 are available in electronic form at http://www.aanda.org

  5. Tectonics and evolution of the Juan Fernandez microplate at the Pacific-Nazca-Antarctic triple junction

    NASA Technical Reports Server (NTRS)

    Anderson-Fontana, S.; Larson, R. L.; Engein, J. F.; Lundgren, P.; Stein, S.

    1986-01-01

    Magnetic and bathymetric profiles derived from the R/V Endeavor survey and focal mechanism studies for earthquakes on two of the Juan Fernandez microplate boundaries are analyzed. It is observed that the Nazca-Juan Fernandez pole is in the northern end of the microplate since the magnetic lineation along the East Ridge of the microplate fans to the south. The calculation of the relative motion of the Juan Fernandez-Pacific-Nazca-Antarctic four-plate system using the algorithm of Minster et al. (1974) is described. The development of tectonic and evolutionary models of the region is examined. The tectonic model reveals that the northern boundary of the Juan Fernandez microplate is a zone of compression and that the West Ridge and southwestern boundary are spreading obliquely; the evolutionary model relates the formation of the Juan Fernandez microplate to differential spreading rates at the triple junction.

  6. Pole of rotating analysis of present-day Juan de Fuca plate motion

    NASA Technical Reports Server (NTRS)

    Nishimura, C.; Wilson, D. S.; Hey, R. N.

    1984-01-01

    Convergence rates between the Juan de Fuca and North American plates are calculated by means of their relative, present-day pole of rotation. A method of calculating the propagation of errors in addition to the instantaneous poles of rotation is also formulated and applied to determine the Euler pole for Pacific-Juan de Fuca. This pole is vectorially added to previously published poles for North America-Pacific and 'hot spot'-Pacific to obtain North America-Juan de Fuca and 'hot spot'-Juan de Fuca, respectively. The errors associated with these resultant poles are determined by propagating the errors of the two summed angular velocity vectors. Under the assumption that hot spots are fixed with respect to a mantle reference frame, the average absolute velocity of the Juan de Puca plate is computed at approximately 15 mm/yr, thereby making it the slowest-moving of the oceanic plates.

  7. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal

    PubMed Central

    Keiser, Jennifer; Panic, Gordana; Vargas, Mireille; Wang, Chunkai; Dong, Yuxiang; Gautam, Nagsen; Vennerstrom, Jonathan L.

    2015-01-01

    Objectives Praziquantel is the only drug available for the treatment of schistosomiasis and the state of the exhausted drug discovery pipeline is alarming. We restarted investigations on the abandoned antischistosomal Ro 13-3978, an aryl hydantoin discovered in the early 1980s by Hoffmann La-Roche. Methods Newly transformed schistosomula and adult Schistosoma mansoni were studied in the presence of Ro 13-3978 in vitro. The metabolic stability of Ro 13-3978 was determined in vitro using human and mouse liver S9 fractions. Dose–response relationship, stage specificity, hepatic shift and scanning electron microscopy studies were carried out in S. mansoni-infected mice. In addition, efficacy experiments were conducted in rodents infected with Echinostoma caproni and Fasciola hepatica as well as in S. mansoni-infected immunocompromised nude (Foxn1nu) mice. Results Ro 13-3978 showed minor in vitro activity and no damage to the tegument was found. No cytotoxicity was detected for Ro 13-3978. Ro 13-3978 was metabolically stable. ED50 values of 138.9 and 14.6 mg/kg were calculated for the treatment of juvenile and adult S. mansoni infections, respectively, with a single oral dose of Ro 13-3978. SEM studies revealed severe damage to the worms 48 h post-treatment of infected mice. A single oral dose of Ro 13-3978 (100 mg/kg) administered to S. mansoni-infected (Foxn1nu) mice reduced the worm burden by 88%. Ro 13-3978 was not active against E. caproni and F. hepatica in vivo. Conclusions Ro 13-3978 has excellent antischistosomal properties in vivo. Structure–activity relationship studies with the aryl hydantoins have been launched in order to elucidate active pharmacophores, further investigate the mechanism of action and to identify a derivative with minimal antiandrogenic effects. PMID:25691324

  8. Sr isotopic variations along the Juan de Fuca Ridge.

    USGS Publications Warehouse

    Eaby, J.; Clague, D.A.; Delaney, J.R.

    1984-01-01

    The Sr isotopic ratios of 39 glass and microcrystalline basalt samples along the Juan de Fuca Ridge and one glass sample from Brown Bear Seamount are at the lower end of the range for normal MORB; the average 87Sr/86Sr ratio is 0.70249 + or - 0.00014 (2sigma ). Although subtle variations exist along the strike of the ridge, the Sr isotopic data do not show systematic variation relative to the proposed Cobb hotspot. The isotopic data are inconsistent with an enriched mantle-plume origin for the Cobb-Eikelberg Seamount chain.-W.H.B.

  9. Mediastinal pathology and the contributions of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst. This review recounts his role as one of the principal figures in the surgical pathology of mediastinal diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Juan Valverde de Hamusco's unauthorized reproduction of a brain dissection by Andreas Vesalius.

    PubMed

    Lanska, Douglas J; Lanska, John R

    2013-02-26

    The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la composicion del cuerpo humano (1556). Illustrations of the brain dissection in the Fabrica were obtained in digital form, resized, and arranged in a comparable montage to that presented by Valverde. Computer manipulations were used to assess image correspondence. The Valverde illustrations are approximately half the size and are mirror images of those in the Fabrica, but otherwise show the same dissection stages, and identical transverse brain levels and structures. The Valverde illustrations lack shadowing and show minor variations in perspective and fine details (e.g., branching pattern of the middle meningeal artery) from those in the Fabrica. Craftsmen under the direction of Valverde copied the woodcut prints in the Fabrica in close but approximate form by freehand engraving onto copper plates. Differences in the sizes of the images, and in perspective and fine detail, preclude direct tracing of images as the means of copying. Because engravings are in effect "flipped over" to make further prints, subsequent prints made from Valverde's copperplate engravings are mirror images of the prints in Vesalius' Fabrica.

  11. VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT 2016)

    NASA Astrophysics Data System (ADS)

    COROT Team

    CoRoT, a space astronomy mission, has measured photometric micro-variability of stars from minutes to months (up to 150 days) with a high duty cycle (more than 90%). The mission was led by CNES in association with four French laboratories and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite was composed of a PROTEUS platform (the 3rd in the series) and a unique instrument: a stellar rapid photometer. It was launched on December 27th 2006 by a Soyuz Rocket, from Baikonour. The mission has lasted almost 6 years (the nominal 3-year duration and a 3-year extension) and has observed more than 160 000 stars. It stopped sending data on November 2nd 2012. Two regions of the sky were accessible for long period of time: circles of 10 degrees centered on the equator around alpha=06:50 and alpha=18:50. They were called the CoRoT eyes: the "anticenter" and the "center eye" (as they are approximately in these directions). Each pointing covers 1.4x2.8 square degrees within one of those CoRoT eyes. The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transit" in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The "bright star" mode dedicated to very precise seismology of a small sample of bright and closeby stars - The "faint star" mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer. The large amount of data gathered in this mode turned out to be extremely fruitful for many topics of stellar physics. Beyond these two initial objectives, CoRoT data revealed stellar variability associated with various other phenomena: granulation, rotational modulation by

  12. Liquefaction during the 1977 San Juan Province, Argentina earthquake (Ms = 7.4)

    USGS Publications Warehouse

    Youd, T.L.; Keefer, D.K.

    1994-01-01

    Liquefaction effects generated by the 1977 San Juan Province, Argentina, earthquake (Ms = 7.4) are described. The larger and more abundant effects were concentrated in the 60-km long band of the lowlands in the Valle del Bermejo and in an equally long band along the Rio San Juan in the Valle de Tulum. Fissures in the Valle del Bermejo were up to several hundred meters long and up to several meters wide. Sand deposits, from boils that erupted through the fissures, covered areas up to tens of square meters. Fissures generally parallelled nearby stream channels. Because the Valle del Bermejo is undeveloped, these large features caused no damage. Liquefaction in the Valle del Tulum caused important or unusual damage at several localities, including the following five sites: (1) At the Barrio Justo P. Castro, a subdivision of Caucete, liquefaction of subsurface sediments decoupled overlying, unliquefied stiff sediments, producing a form of ground failure called "ground oscillation". The associated differential ground movements pulled apart houses and pavements in extension, while shearing curbs and buckling canal linings in compression at the same locality. (2) At the Escuela Normal, in Caucete, the roof of a 30-m long single-story classroom building shifted westward relative to the foundation. That displacement fractured and tilted columns supporting the roof. The foundation was fractured at several places, leaving open cracks, as wide as 15 mm. The cumulative width of the open cracks was 48 mm, an amount roughly equivalent to the 63 mm of offset between the roof and foundation at the east end of the building. The ground and foundation beneath the building extended (or spread) laterally opening cracks and lengthening the foundation while the roof remained in place. (3) The most spectacular damage to structures at the community of San Martin was the tilting of a 6-m high water tower and the toppling of a nearby pump house into a 1-m deep crater. Similarly, a small

  13. Anti-SSA Ro52/Ro60 antibody testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA.

    PubMed

    Mekinian, Arsène; Nicaise-Roland, Pascale; Chollet-Martin, Sylvie; Fain, Olivier; Crestani, Bruno

    2013-12-01

    The objective of this study was to assess the diagnostic value of anti-Ro52/60 antibodies by immunodot in patients with suspected SS. All patients between 2008 and 2012 with suspected SS without anti-SSA/SSB antibodies by ELISA and who had a determination of anti-SSA (Ro52/Ro60) antibodies by immunodot (Euroimmun, Germany) were retrospectively analysed. Eighty-four patients (median age 62 years; males 35 cases) were included. Forty-five patients had associated interstitial lung disease (ILD). American-European Consensus Group (AECG) criteria for SS were fulfilled in 10 patients (12%) with a positive salivary gland biopsy, and among them 2 patients had anti-Ro52 antibodies by dot (20%). Among 74 patients with a negative salivary gland biopsy, 16 (22%) had anti-Ro52/60 antibodies and 10 (14%) fulfilled AECG criteria when including Ro52/60 antibodies. A comparison of patients with and without anti-Ro52/60 antibodies revealed no differences, except gamma globulin levels and more frequent steroid use in patients with anti-Ro52/60 antibodies (P < 0.05). In 45 patients with ILD and dry eye/mouth syndrome, 10 (22%) had positive anti-Ro52/60 antibodies. In these patients 2 (4%) fulfilled AECG criteria without anti-Ro52/60 antibodies vs 4 (8%) patients if anti-Ro52/60 antibodies were included. In patients with dry eye/mouth syndrome without anti-SSA/SSB antibodies by ELISA, the detection of anti-Ro52/Ro60 antibodies by dot could help in the diagnosis of SS. In patients with ILD, the lower frequency of a Chisholm score ≥3 enhances the interest of anti-Ro52/Ro60 screening.

  14. The Fate of the Juan de Fuca Plate

    NASA Astrophysics Data System (ADS)

    Xue, M.; Allen, R. M.

    2006-12-01

    The Juan de Fuca plate is subducting beneath the northwestern United States and southwestern Canada. Although the slab has been imaged to depths of at least ~{400} km beneath Washington and at least ~{200} to 300 km beneath northern Oregon with a dip of ~60° to the east, there is little evidence for a slab east of High Cascades deeper than ~150 km beneath central and ~200 km beneath southern Oregon. To image the slab beneath Oregon, we apply tomography technique using a dataset consisting of our own OATS deployment and all other available data. For the Vs inversion, a total of 95 events with clear S and SKS phases were recorded at 45 stations and a total number of 2148 rays were used. For the Vp inversion, a total of 74 events with clear direct P phase were recorded at 46 stations, and a total number of 2043 rays were used. Our tomographic images clearly show that the Juan de Fuca plate dives into the mantle beneath Oregon and continues east of the High Cascades with a dip of ~50° reaching a depth of ~400 km. The slab does not dip more vertically than its counterparts to north and south, which have a dip of ~60° and ~65° respectively. Resolution tests suggest there is little or no velocity anomaly associated with a slab below ~400 km.

  15. San Juan Basin contains large reserves of nonassociated gas

    SciTech Connect

    Rice, D.D.; Threlkeld, C.N.

    1983-03-07

    Approximately 23 trillion CF of nonassociated gas occurs in the underpressured, low-permeability reservoirs in the essentially structureless low part of the central San Juan basin in northwestern New Mexico and southwestern Colorado. Characteristics and distribution of natural gas and associated hydrocarbons (oil and condensate) for all producing units indicate an increased level of maturation to the northeast: (1) Pennsylvania production is limited mostly to the Four Corners platform, where oil production changes in a northeasterly direction to isotopically heavy dry gas with H/sub 2/S and CO/sub 2/, (2) hydrocarbon production from the Dakota sandstone displays a northeast change from oil to wet gas and condensate to dry gas, (3) the Tocito sandstone Lentil of Mancos shale is a major producer of oil and associated gas in the basin, (4) the Mesaverde contains large quantities of nonassociated gas generated mainly from nonmarine source rocks, and (5) Pictured Cliffs gases (probably derived from associated coalbeds) are isotopically heavier and chemically drier than gases from the underlying Mesaverde group and produced very little condensate. Significant reserves of nonassociated gas remain in the San Juan basin - the primary targets for future exploration will be the coalbeds in the Fruitland formation, channel sandstones and coalbeds in the Menefee formation, and low-permeability sandstones in all units at the north end of the basin.

  16. Tumor-infiltrating CD45RO(+) Memory T Lymphocytes Predict Favorable Clinical Outcome in Solid Tumors.

    PubMed

    Hu, Guoming; Wang, Shimin

    2017-09-04

    The prognostic role of tumor-infiltrating CD45RO(+) memory T lymphocytes (CD45RO(+) T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO(+) T cells in human solid tumors. We found that CD45RO(+) T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, CD45RO(+) T cell infiltration significantly improved 1-year, 3-year and 5-year OS in colorectal, gastric and esophageal cancer, but only 5-year OS in hepatocellular carcinoma. And these cells were positively associated with 1-year, 3-year and 5-year DFS in hepatocellular, colorectal and esophageal cancer. In addition, high density of intratumoral CD45RO(+) T cells inversely correlated with TNM stage of solid tumor. In conclusion, CD45RO(+) memory T lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances.

  17. Experimental results from RO-PRO: a next generation system for low-energy desalination.

    PubMed

    Achilli, Andrea; Prante, Jeri L; Hancock, Nathan T; Maxwell, Eric B; Childress, Amy E

    2014-06-03

    A pilot system was designed and constructed to evaluate reverse osmosis (RO) energy reduction that can be achieved using pressure-retarded osmosis (PRO). The RO-PRO experimental system is the first known system to utilize energy from a volume of water transferred from atmospheric pressure to elevated pressure across a semipermeable membrane to prepressurize RO feedwater. In other words, the system demonstrated that pressure could be exchanged between PRO and RO subsystems. Additionally, the first experimental power density data for a RO-PRO system is now available. Average experimental power densities for the RO-PRO system ranged from 1.1 to 2.3 W/m2. This is higher than previous river-to-sea PRO pilot systems (1.5 W/m2) and closer to the goal of 5 W/m2 that would make PRO an economically feasible technology. Furthermore, isolated PRO system testing was performed to evaluate PRO element performance with higher cross-flow velocities and power densities exceeding 8 W/m2 were achieved with a 28 g/L NaCl draw solution. From this empirical data, inferences for future system performance can be drawn that indicate future RO-PRO systems may reduce the specific energy requirements for desalination by ∼1 kWh/m3.

  18. Rapid field assessment of RO desalination of brackish agricultural drainage water.

    PubMed

    Thompson, John; Rahardianto, Anditya; Gu, Han; Uchymiak, Michal; Bartman, Alex; Hedrick, Marcos; Lara, David; Cooper, Jim; Faria, Jose; Christofides, Panagiotis D; Cohen, Yoram

    2013-05-15

    Rapid field evaluation of RO feed filtration requirements, selection of effective antiscalant type and dose, and estimation of suitable scale-free RO recovery level were demonstrated using a novel approach based on direct observation of mineral scaling and flux decline measurements, utilizing an automated Membrane Monitor (MeMo). The MeMo, operated in a stand-alone single-pass desalting mode, enabled rapid assessment of the adequacy of feed filtration by enabling direct observation of particulate deposition on the membrane surface. The diagnostic field study with RO feed water of high mineral scaling propensity revealed (via direct MeMo observation) that suspended particulates (even for feed water of turbidity <1 NTU) could serve as seeds for promoting surface crystal nucleation. With feed filtration optimized, a suitable maximum RO water recovery, with complete mineral scale suppression facilitated by an effective antiscalant dose, can be systematically and directly identified (via MeMo) in the field for a given feed water quality. Scale-free operating conditions, determined via standalone MeMo rapid diagnostic tests, were shown to be applicable to spiral-would RO system as validated via both flux decline measurements and ex-situ RO plant membrane scale monitoring. It was shown that the present approach is suitable for rapid field assessment of RO operability and it is particularly advantageous when evaluating water sources of composition that may vary both temporally and across the regions of interest.

  19. WARM SPITZER PHOTOMETRY OF THE TRANSITING EXOPLANETS CoRoT-1 AND CoRoT-2 AT SECONDARY ECLIPSE

    SciTech Connect

    Deming, Drake; Knutson, Heather; Agol, Eric; Cowan, Nicolas B.; Desert, Jean-Michel; Charbonneau, David; Burrows, Adam; Fortney, Jonathan J.; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P.; Lewis, Nikole K.

    2011-01-10

    We measure secondary eclipses of the hot giant exoplanets CoRoT-1 at 3.6 and 4.5 {mu}m, and CoRoT-2 at 3.6 {mu}m, both using Warm Spitzer. We find that the Warm Spitzer mission is working very well for exoplanet science. For consistency of our analysis we also re-analyze archival cryogenic Spitzer data for secondary eclipses of CoRoT-2 at 4.5 and 8 {mu}m. We compare the total data for both planets, including optical eclipse measurements by the CoRoT mission, and ground-based eclipse measurements at 2 {mu}m, to existing models. Both planets exhibit stronger eclipses at 4.5 than at 3.6 {mu}m, which is often indicative of an atmospheric temperature inversion. The spectrum of CoRoT-1 is best reproduced by a 2460 K blackbody, due either to a high altitude layer that strongly absorbs stellar irradiance, or an isothermal region in the planetary atmosphere. The spectrum of CoRoT-2 is unusual because the 8 {mu}m contrast is anomalously low. Non-inverted atmospheres could potentially produce the CoRoT-2 spectrum if the planet exhibits line emission from CO at 4.5 {mu}m, caused by tidal-induced mass loss. However, the viability of that hypothesis is questionable because the emitting region cannot be more than about 30% larger than the planet's transit radius, based on the ingress and egress times at eclipse. An alternative possibility to account for the spectrum of CoRoT-2 is an additional opacity source that acts strongly at wavelengths less than 5 {mu}m, heating the upper atmosphere while allowing the deeper atmosphere seen at 8 {mu}m to remain cooler. We obtain a similar result as Gillon et al. for the phase of the secondary eclipse of CoRoT-2, implying an eccentric orbit with e cos({omega}) = -0.0030 {+-} 0.0004.

  20. Gibberellins regulate the transcription of the continuous flowering regulator, RoKSN, a rose TFL1 homologue

    PubMed Central

    Foucher, Fabrice

    2012-01-01

    The role of gibberellins (GAs) during floral induction has been widely studied in the annual plant Arabidopsis thaliana. Less is known about this control in perennials. It is thought that GA is a major regulator of flowering in rose. In spring, low GA content may be necessary for floral initiation. GA inhibited flowering in once-flowering roses, whereas GA did not block blooming in continuous-flowering roses. Recently, RoKSN, a homologue of TFL1, was shown to control continuous flowering. The loss of RoKSN function led to continuous flowering behaviour. The objective of this study was to understand the molecular control of flowering by GA and the involvement of RoKSN in this inhibition. In once-flowering rose, the exogenous application of GA3 in spring inhibited floral initiation. Application of GA3 during a short period of 1 month, corresponding to the floral transition, was sufficient to inhibit flowering. At the molecular level, RoKSN transcripts were accumulated after GA3 treatment. In spring, this accumulation is correlated with floral inhibition. Other floral genes such as RoFT, RoSOC1, and RoAP1 were repressed in a RoKSN-dependent pathway, whereas RoLFY and RoFD repression was RoKSN independent. The RoKSN promoter contained GA-responsive cis-elements, whose deletion suppressed the response to GA in a heterologous system. In summer, once-flowering roses did not flower even after exogenous application of a GA synthesis inhibitor that failed to repress RoKSN. A model is presented for the GA inhibition of flowering in spring mediated by the induction of RoKSN. In summer, factors other than GA may control RoKSN. PMID:23175671

  1. El círculo meridiano automático de San Fernando - San Juan. Sus primeros pasos en el hemisferio sur

    NASA Astrophysics Data System (ADS)

    Mallamaci, C. C.; Muiños, J. L.; Gallego, M.; Pérez, J. A.; Marmolejo, L.; Navarro, J. L.; Sedeño, J.; Vallejos, M.; Belizón, F.

    Se informa sobre el estado actual del Círculo Meridiano Automático de San Fernando-San Juan. El instrumento (Grubb-Parson, de 178mm de abertura y 2665 mm de distancia focal) es gemelo del que se encuentra en las Islas Canarias, y fue instalado durante los meses de julio y agosto de 1996 en la estación astronómica ``Dr. C.U.Cesco" (El Leoncito, Barreal), a unos 200 km de distancia de la ciudad de San Juan, merced a un Convenio de Cooperación Científica, firmado en 1994 entre el ROA (España) y el OAFA (Argentina). En la actualidad se está llevando a cabo un programa de prueba cuyos resultados preliminares muestran que el telescopio está en buenas condiciones para observar estrellas de hasta magnitud aproximada 14.5, con buenos errores de observación (<0.12" en ascensión recta y declinación).

  2. Ceftriaxone (Ro 13-9904) therapy of serious infection.

    PubMed Central

    Bradsher, R W

    1982-01-01

    Ceftriaxone (Ro 13-9904), a newly developed cephalosporin with a long half-life, was evaluated for efficacy and safety in 19 patients with serious infections. Underlying illnesses were present in 16 patients. Ceftriaxone was given intravenously every 12 h. Infections treated included gram-negative bacillary pneumonias (two cases), staphylococcal and streptococcal soft tissue-skeletal infections (six cases), spontaneous peritonitis (two cases), and complicated urinary tract infections (nine cases). Bacteremia was present in three patients. Microbiological and clinical cures were achieved in all but one case, although three patients with urinary infection had recurrences 6 weeks posttherapy. The only failure occurred in a patient with pneumonia who had a Pseudomonas aeruginosa isolated from sputum with an initial minimal inhibitory concentration of 4 micrograms/ml, but after 9 days of therapy, a repeat isolate had a minimal inhibitory concentration of 32 micrograms/ml. The minimal inhibitory concentrations for the other isolates ranged from less than or equal to 0.6 to 8.0 micrograms/ml. The mean peak plasma level of ceftriaxone was 99.9 micrograms/ml. The only side effects noted were drug fever in one patient, phlebitis in two patients, and thrombocytosis in four patients. PMID:6289739

  3. Magnetic Field Modeling of the Northern Juan De Fuca and Explorer Plates

    DTIC Science & Technology

    1993-07-01

    THE i NORTHERN JUAN DE FUCA AND EXPLORER PLATES I I JOHN M. QUINN DONALD L. SHIEL DTIC "ELECTE 1AU 18 1994U s.I GD SI q •-(494-26093I...concerns a low-level Project MAGNET survey of the northern Juan de Fuca and Explorer Plates , a region of intense scientific interest due to its volcanic...Juan de Fuca and Explorer Plates 5. AUTHOR(S) John H. Quinn Donald L. Shiel 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING

  4. Bedrock aquifers of eastern San Juan County, Utah

    USGS Publications Warehouse

    Avery, Charles

    1986-01-01

    This study is one of a series of studies appraising the waterbearing properties of the Navajo Sandstone and associated formations in southern Utah.  The stu<¥ area is al:x>dy area is about 4,600 square miles, extending from the Utah-Arizona State line northward to the San Juan-Grand County line and westward from the Utah-Colorado State line to the longitude of about 109°50'.Some of the water-yielding formations are grouped into aquifer systems. The C aquifer is comprised of the DeChelly Sandstone Member of the Cutler Formation.  The P aquifer is comprised of the Cedar Mesa Member of the Cutler Formation and the undifferentiated Cutler Formation. The N aquifer is comprised of the sedimentary section that includes the Wingate Sandstone, Kayenta Formation, Navajo Sandstone, Carmel Formation, and Entrada sandstone.  The M aquifer is comprised of the Bluff Sandstone Member and other sandstone units of the Morrison Formation.  The D aquifer is comprised of the Burro Canyon Formation and Dakota Sandstone.  Discharge from the ground-water reservoir to the San Juan River between gaging stations at Four Corners and Mexican Hat is about 66 cubic feet per second.The N aquifer is the main aquifer in the study area. Recharge by infiltration of precipitation is estimated to be 25,000 acre-feet per year.  A major ground-water divide exists under the broad area east of Monticello.  The thickness of the N aquifer, where the sedimentary section is fully preserved and saturated, generally is 750 to 1,250 feet.   Hydraulic conductivity values obtained from aquifer tests range from 0.02 to 0.34 foot per day.  The total volume of water in transient storage is about 11 million acre-feet. Well discharge somewhat exceeded 2,340 acre-feet during 1981.  Discharge to the San Juan River from the N aquifer is estimated to be 6.9 cubic feet per second. Water quality ranges from a calcium bicarbonate to sodium chloride type water

  5. Transiting exoplanets from the CoRoT space mission. VII. The ``hot-Jupiter''-type planet CoRoT-5b

    NASA Astrophysics Data System (ADS)

    Rauer, H.; Queloz, D.; Csizmadia, Sz.; Deleuil, M.; Alonso, R.; Aigrain, S.; Almenara, J. M.; Auvergne, M.; Baglin, A.; Barge, P.; Bordé, P.; Bouchy, F.; Bruntt, H.; Cabrera, J.; Carone, L.; Carpano, S.; de La Reza, R.; Deeg, H. J.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guillot, T.; Guenther, E.; Hatzes, A.; Hébrard, G.; Kabath, P.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Rabus, M.; Renner, S.; Rouan, D.; Shporer, A.; Samuel, B.; Schneider, J.; Triaud, A. H. M. J.; Wuchterl, G.

    2009-10-01

    Aims: The CoRoT space mission continues to photometrically monitor about 12 000 stars in its field-of-view for a series of target fields to search for transiting extrasolar planets ever since 2007. Deep transit signals can be detected quickly in the “alarm-mode” in parallel to the ongoing target field monitoring. CoRoT's first planets have been detected in this mode. Methods: The CoRoT raw lightcurves are filtered for orbital residuals, outliers, and low-frequency stellar signals. The phase folded lightcurve is used to fit the transit signal and derive the main planetary parameters. Radial velocity follow-up observations were initiated to secure the detection and to derive the planet mass. Results: We report the detection of CoRoT-5b, detected during observations of the LRa01 field, the first long-duration field in the galactic anti-center direction. CoRoT-5b is a “hot Jupiter-type” planet with a radius of 1.388+0.046-0.047 R_Jup, a mass of 0.467+0.047-0.024 M_Jup, and therefore, a mean density of 0.217+0.031-0.025 g cm-3. The planet orbits an F9V star of 14.0 mag in 4.0378962 ± 0.0000019 days at an orbital distance of 0.04947+0.00026-0.00029 AU. Observations made with SOPHIE spectrograph at the Observatoire de Haute Provence (07B.PNP.MOUT), France, and HARPS spectrograph at ESO La Silla Observatory (072.C-0488(E), 082.C-0312(A)), and partly based on observations made at the Anglo-Australian Telescope. The CoRoT space mission, launched on December 27, 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.

  6. In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements.

    PubMed

    Hempel, Leonie U; Rathke, Christina; Raja, Sunil Jayaramaiah; Renkawitz-Pohl, Renate

    2006-04-01

    The genes don juan (dj) and don juan like (djl) encode basic proteins expressed in the male germline. Both proteins show a similar expression pattern being localized in the sperm heads during chromatin condensation and along the flagella. Prematurely expressed Don Juan-eGFP and Myc-Don Juan Like localize to the cytoplasm of spermatocytes and in mitochondrial derivatives from the nebenkern stage onward suggesting that both proteins associate with the mitochondria along the flagella in elongated spermatids. Premature expression of Myc-Don Juan Like does not impair spermatogenesis where-as Don Juan-eGFP when prematurely expressed causes male sterility as spermatids fail to individualize. In spite of the sequence identity of 72% on the nucleotide level and 42% on the protein level, the presumptive promoter regions and the untranslated regions of the mRNA are diverged. Our in vivo analysis revealed that don juan and don juan like are transcriptionally and translationally controlled by distinct short cis regulatory regions. Transcription of don juan and don juan like depends on the male germ line specific TAF(II)80, Cannonball (Can). Translational repression elements for both mRNAs are localized in the 5' UTR and are capable to form distinct secondary structures in close proximity to the translational initiation codon.

  7. Roll-On/Roll-Off (RO/RO) Discharge Facility Tests with MV CYGNUS and SS ATLANTIC BEAR (COTS CNO Project 299, DT-IIF-1).

    DTIC Science & Technology

    1983-11-01

    AD-R139 346 ROLL-ON/ROLL-OFF (RO/RO) DISCHARGE FACILITY TESTS NITH 1/1 MY CYGNUS AND SS A..(U) DAVID N TAYLOR NAVAL SHIP RESEARCH AND DEVELOPMENT...MICROCOPY RESOLUTION TEST CHART NATIONA. DUEAU OF STANOAD$S-1963-A •-’ ,jh DAVID W. TAYLOR NAVAL SHIP RMSEARCH AND DEVELOPMENT CENTER ROLL-ON/ROLL...by the David W. Taylor Naval Ship Research and Development Center (DTNSRDC), Mobile Support Systems Office, Code 1190, Task Area Y0816.002 and Work

  8. Transiting exoplanets from the CoRoT space mission. XXV. CoRoT-27b: a massive and dense planet on a short-period orbit

    NASA Astrophysics Data System (ADS)

    Parviainen, H.; Gandolfi, D.; Deleuil, M.; Moutou, C.; Deeg, H. J.; Ferraz-Mello, S.; Samuel, B.; Csizmadia, Sz.; Pasternacki, T.; Wuchterl, G.; Havel, M.; Fridlund, M.; Angus, R.; Tingley, B.; Grziwa, S.; Korth, J.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Baglin, A.; Barros, S. C. C.; Bordé, P.; Bouchy, F.; Cabrera, J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Guillot, T.; Hatzes, A.; Hébrard, G.; Mazeh, T.; Montagnier, G.; Ofir, A.; Ollivier, M.; Pätzold, M.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.

    2014-02-01

    Aims: We report the discovery of a massive and dense transiting planet CoRoT-27b on a 3.58-day orbit around a 4.2 Gyr-old G2 star. The planet candidate was identified from the CoRoT photometry, and was confirmed as a planet with ground-based spectroscopy. Methods: The confirmation of the planet candidate is based on radial velocity observations combined with imaging to rule out blends. The characterisation of the planet and its host star was carried out using a Bayesian approach where all the data (CoRoT photometry, radial velocities, and spectroscopic characterisation of the star) are used jointly. The Bayesian analysis included a study whether the assumption of white normally distributed noise holds for the CoRoT photometry and whether the use of a non-normal noise distribution offers advantages in parameter estimation and model selection. Results: CoRoT-27b has a mass of 10.39 ± 0.55MJup, a radius of 1.01 ± 0.04RJup, a mean density of 12.6-1.67+1.92g cm-3, and an effective temperature of 1500 ± 130 K. The planet orbits around its host star, a 4.2 Gyr-old G2-star with a mass M⋆ = 1.06M⊙ and a radius R⋆ = 1.05R⊙, on a 0.048 ± 0.007 AU orbit of 3.58 days. The radial velocity observations allow us to exclude highly eccentric orbits, namely, e < 0.065 with 99% confidence. Given its high mass and density, theoretical modelling of CoRoT-27b is demanding. We identify two solutions with heavy element mass fractions of 0.11 ± 0.08M⊕ and 0.07 ± 0.06M⊕, but even solutions void of heavy elements cannot be excluded. We carry out a secondary eclipse search from the CoRoT photometry using a method based on Bayesian model selection, but conclude that the noise level is too high to detect eclipses shallower than 9% of the transit depth. Using a non-normal noise model was shown not to affect the parameter estimation results, but led to significant improvement in the sensitivity of the model selection process. The CoRoT space mission, launched on December 27, 2006

  9. Quality of life in functional rhinoplasty: rhinoplasty outcomes evaluation German version (ROE-D).

    PubMed

    Bulut, Olcay Cem; Plinkert, Peter K; Wallner, Frank; Baumann, Ingo

    2016-09-01

    The aim of this study was to validate a German version of the rhinoplasty outcomes evaluation (ROE) questionnaire. A prospective study was conducted and a German translated ROE (ROE-D) questionnaire administered to 100 patients preoperatively, 6 and 12 months postoperatively. The translation was performed according to internationally accepted guidelines. To validate this instrument, we evaluated its reliability, validity and sensitivity. ROE-D was completed by 54 patients after 6 months and by 69 patients 1 year after functional rhinoplasty. Cronbach's α indicated good internal consistency. Reliability was tested with a split-half-reliability, showing significant correlation. Discrimination validity was demonstrated by a comparison with healthy controls. Sensitivity to change showed medium to large effects. ROE-D is a reliable, validated and sensitive German instrument for measuring health-related quality of life in patients after rhinoplasty. The ROE-D focuses mainly on the aesthetic aspects of the rhinoplasty surgery.

  10. Nonvariational Orbital Optimization Techniques for the AP1roG Wave Function.

    PubMed

    Boguslawski, Katharina; Tecmer, Paweł; Bultinck, Patrick; De Baerdemacker, Stijn; Van Neck, Dimitri; Ayers, Paul W

    2014-11-11

    We introduce new nonvariational orbital optimization schemes for the antisymmetric product of one-reference orbital geminal (AP1roG) wave function (also known as pair-coupled cluster doubles) that are extensions to our recently proposed projected seniority-two (PS2-AP1roG) orbital optimization method [ J. Chem. Phys. 2014 , 140 , 214114 )]. These approaches represent less stringent approximations to the PS2-AP1roG ansatz and prove to be more robust approximations to the variational orbital optimization scheme than PS2-AP1roG. The performance of the proposed orbital optimization techniques is illustrated for a number of well-known multireference problems: the insertion of Be into H2, the automerization process of cyclobutadiene, the stability of the monocyclic form of pyridyne, and the aromatic stability of benzene.

  11. Anti-Ro/SSA antibodies are associated with severe mitral valve regurgitation in patients with systemic lupus erythematosus.

    PubMed

    Higuera-Ortiz, Violeta; Mora-Arias, Tania; Castillo-Martinez, Diana; Amezcua-Guerra, Luis M

    2017-05-01

    To assess whether anti-Ro/SSA antibodies are associated with cardiac valve disease in lupus. A single-center, medical chart review was performed. Lupus patients were divided according to its anti-Ro/SSA status and subgroups were compared for valvular abnormalities and other characteristics. Dependence of anti-Ro/SSA reactivity to anti-Ro52/TRIM21 antibodies was also evaluated. Eighty-nine lupus patients were analyzed. The most common valvular abnormalities were tricuspid (60%), mitral (41%) and pulmonary (14%) regurgitation. Thirty-six patients were positive and 53 negative for anti-Ro/SSA antibodies. In patients positive to anti-Ro/SSA, a difference was noted for anti-dsDNA (67 versus 45%; p = 0.04) and anti-La/SSB (19 versus 2%; p = 0.004) antibodies. An association between anti-Ro/SSA antibodies and severe mitral regurgitation was observed; indeed, 4/15 patients with anti-Ro/SSA and mitral regurgitation had severe forms of valvulopathy as compared to only 1/22 patients with mitral regurgitation but negative to such antibody (27 versus 5%; p = 0.02). Anti-Ro/SSA antibodies significantly elevated the risk of severe mitral regurgitation (OR = 5). Anti-Ro52/TRIM21 levels (103 ± 29 versus 42 ± 43 U/mL; p = 0.03) and anti-Ro52/TRIM21: anti-Ro/SSA ratios (0.88 ± 0.02 versus 0.35 ± 0.37; p = 0.03) were higher in patients with mitral valve regurgitation than in those with no valvulopathy. Anti-Ro/SSA antibodies, mainly against Ro52/TRIM21 antigens, may be pathologically involved in lupus-associated mitral valve regurgitation.

  12. The influence of antiscalants on biofouling of RO membranes in seawater desalination.

    PubMed

    Sweity, Amer; Oren, Yoram; Ronen, Zeev; Herzberg, Moshe

    2013-06-15

    Antiscalants are surface active polyelectrolyte compounds commonly used in reverse osmosis (RO) desalination processes to avoid membrane scaling. In spite of the significant roles of antiscalants in preventing membrane scaling, they are prone to enhance biofilm growth on RO membranes by either altering membrane surface properties or by serving as nutritional source for microorganisms. In this study, the contribution of antiscalants to membrane biofouling in seawater desalination was investigated. The effects of two commonly used antiscalants, polyphosphonate- and polyacrylate-based, were tested. The effects of RO membrane (DOW-Filmtec SW30 HRLE-400) exposure to antiscalants on its physico-chemical properties were studied, including the consequent effects on initial deposition and growth of the sessile microorganisms on the RO membrane surface. The effects of antiscalants on membrane physico-chemical properties were investigated by filtration of seawater supplemented with the antiscalants through flat-sheet RO membrane and changes in surface zeta potential and hydrophobicity were delineated. Adsorption of antiscalants to polyamide surfaces simulating RO membrane's polyamide layer and their effects on the consequent bacterial adhesion was tested using a quartz crystal microbalance with dissipation monitoring technology (QCM-D) and direct fluorescent microscopy. A significant increase in biofilm formation rate on RO membranes surface was observed in the presence of both types of antiscalants. Polyacrylate-based antiscalant was shown to enhance initial cell attachment as observed with the QCM-D and a parallel plate flow cell, due to rendering the polyamide surface more hydrophobic. Polyphosphonate-based antiscalants also increased biofilm formation rate, most likely by serving as an additional source of phosphorous to the seawater microbial population. A thicker biofilm layer was formed on the RO membrane when the polyacrylate-based antiscalant was used. Following

  13. Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis

    PubMed Central

    2012-01-01

    Introduction Autoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood. We undertook this study to determine the clinical and serologic associations of anti-Ro52/TRIM21 antibodies in patients with systemic sclerosis (SSc). Methods Detailed clinical data and sera from 963 patients with SSc enrolled in a multicenter cohort study were collected and entered into a central database. Antibodies to Ro52/TRIM21 and other autoantibodies were detected with an addressable laser-bead immunoassay and different enzyme-linked immunosorbent assay (ELISA) systems. Associations between anti-Ro52/TRIM21 antibodies and clinical and other serologic manifestations of SSc were investigated. Results Anti-Ro52/TRIM21 antibodies were present in 20% of SSc patients and overlapped with other main SSc-related antibodies, including anti-centromere (by immunofluorescence and centromere protein (CENP)-A and CENP-B ELISA), anti-topoisomerase I, anti-RNA polymerase III, and anti-Pm/Scl antibodies. Anti-Ro52/TRIM21 antibodies were strongly associated with interstitial lung disease (odds ratio (OR), 1.53; 95% confidence interval (CI), 1.11 to 2.12; P = 0.0091) and overlap syndrome (OR, 2.06; 95% CI, 1.01 to 4.19; P = 0.0059). Conclusions Anti-Ro52/TRIM21 antibodies were the second most common autoantibodies in this SSc cohort. In SSc, anti-Ro52/TRIM21 antibodies may be a marker of interstitial lung disease and overlap syndrome. PMID:22394602

  14. Percutaneous endovascular management of occluded HeRO dialysis access device.

    PubMed

    Vasquez, Julio C; DeLaRosa, Jacob; Leon, Juan J; Rahim, Naeem; Rahim, Fahim

    2010-01-01

    The Hemodialysis Reliable Outflow (HeRO) device is a novel alternative for dialysis access in patients with no suitable veins in the upper extremities. We placed a HeRO device in a 67-year-old woman with end-stage renal disease and 2 months later, it was being used for hemodialysis. After 1 month of uneventful use, the device thrombosed and it was rescued with a percutaneous endovascular approach. The device remains patent 6 months after the intervention.

  15. Association of anti-Ro/SSA antibody with response to biologics in patients with rheumatoid arthritis.

    PubMed

    Hagiwara, Shinya; Tsuboi, Hiroto; Honda, Fumika; Takahashi, Hidenori; Kurata, Izumi; Ohyama, Ayako; Yagishita, Mizuki; Abe, Saori; Kurashima, Yuko; Kaneko, Syunta; Kawaguchi, Hoshimi; Takahashi, Hiroyuki; Ebe, Hiroshi; Yokosawa, Masahiro; Asashima, Hiromitsu; Hirota, Tomoya; Umeda, Naoto; Kondo, Yuya; Matsumoto, Isao; Sumida, Takayuki

    2016-11-01

    To compare the effectiveness of three different biologics in anti-Ro/SSA antibody-positive and antibody-negative patients with rheumatoid arthritis (RA). The study subjects were 110 biologics naïve patients with RA who started treatment with biologics and examined for anti-Ro/SSA antibody between December 2003 and March 2014. For patients treated with intravenous infliximab (IFX), tocilizumab (TCZ), or abatacept (ABT), we compared the clinical characteristics and changes in composite disease activity index, such as DAS28, SDAI, and CDAI, for 12 months in anti-Ro/SSA antibody-positive and antibody-negative patients. We examined 59 patients (nine were positive and 50 were negative for anti-Ro/SSA antibody) treated with IFX, 27 patients (5 positive and 22 negative) treated with TCZ, and 24 patients (13 positive and 11 negative) treated with ABT. For patients treated with IFX, parameters of disease activity did not change significantly from baseline in anti-Ro/SSA antibody-positive patients, whereas they improved in antibody-negative patients. On the other hand, treatment with TCZ and ABT significantly decreased disease activity, relative to baseline, in both anti-Ro/SSA antibody-positive and antibody-negative patients. Anti-Ro/SSA antibody-positive patients treated with IFX showed higher frequency of HACA and seroconversion of ANA, and lower serum TGF-β levels. Positivity to anti-Ro/SSA in RA seems to confer resistance to IFX via production of HACA and ANA, and low serum TGF-β levels, but not to TCZ and ABT.

  16. Distribution of hydrothermal manganese over the Juan de Fuca Ridge

    SciTech Connect

    Jones, C.J.; Johnson, H.P.; Delaney, J.R.

    1981-08-01

    Bottom waters from five hydrographic stations, spaced equally along a 400-km section of the Juan de Fuca Ridge north of the Blanco Fracture Zone, contain anomalously high concentrations of total dissolvable manganese (TDM). The two bottom-most bottles from each hydrocast (approx. 100 to 200 m above bottom) range from 8.3 to 108.9 nmol kg/sup -1/ with a median value of 12.0 nmol kg/sup -1/. This median is nearly a factor of 10 higher than similar near bottom samples obtained from two off-axis locations. Analogy to work on the East Pacific Rise implies that hydrothermal activity along the ridge axis is contributing substantially to the manganese content of the water column in this portion of the northeastern Pacific.

  17. Central San Juan caldera cluster: Regional volcanic framework

    USGS Publications Warehouse

    Lipman, Peter W.

    2000-01-01

    Eruption of at least 8800 km3 of dacitic-rhyolitic magma as 9 major ash-slow sheets (individually 150-5000 km3) was accompanied by recurrent caldera subsidence between 28.3 and about 26.5 Ma in the central San Juan Mountains, Colorado. Voluminous andesitic-decitic lavas and breccias were erupted from central volcanoes prior to the ash-flow eruptions, and similar lava eruptions continued within and adjacent to the calderas during the period of explosive volcanism, making the central San Juan caldera cluster an exceptional site for study of caldera-related volcanic processes. Exposed calderas vary in size from 10 to 75 km in maximum diameter, the largest calderas being associated with the most voluminous eruptions. After collapse of the giant La Garita caldera during eruption if the Fish Canyon Tuff at 17.6 Ma, seven additional explosive eruptions and calderas formed inside the La Garita depression within about 1 m.y. Because of the nested geometry, maximum loci of recurrently overlapping collapse events are inferred to have subsided as much as 10-17 km, far deeper than the roof of the composite subvolcanic batholith defined by gravity data, which represents solidified caldera-related magma bodies. Erosional dissection to depths of as much as 1.5 km, although insufficient to reach the subvolcanic batholith, has exposed diverse features of intracaldera ash-flow tuff and interleaved caldera-collapse landslide deposits that accumulated to multikilometer thickness within concurrently subsiding caldera structures. The calderas display a variety of postcollapse resurgent uplift structures, and caldera-forming events produced complex fault geometries that localized late mineralization, including the epithermal base- and precious-metal veins of the well-known Creede mining district. Most of the central San Juan calderas have been deeply eroded, and their identification is dependent on detailed geologic mapping. In contrast, the primary volcanic morphology of the

  18. CHAMA-SOUTHERN SAN JUAN MOUNTAINS WILDERNESS STUDY AREA, COLORADO.

    USGS Publications Warehouse

    Brock, Maurice R.; Lindquist, Alec E.

    1984-01-01

    A mineral survey of the Chama-southern San Juan Mountains Wilderness study area in Colorado revealed demonstrated coal resources in an area of substantiated coal resource potential and areas of probable resource potential for petroleum and metals including molydenum, copper, zinc, lead, and silver. The coal deposit that underlies the northwestern part of the study area at its westernmost extension requires further study for a more accurate determination of the coal resources that underlie the area. Drilling also is required to determine depth, magnitude, and tenor of the postulated porphyry deposit containing copper and molybdenum in the northernmost part of the study area. Geophysical surveys and detailed geologic mapping in advance of drilling are needed in the areas delineated as having potential for oil and gas resources.

  19. Diagnostic electron microscopy and the influence of Dr. Juan Rosai.

    PubMed

    Wick, Mark R

    2016-09-01

    Transmission electron microscopy (TEM) was introduced by Ruska and Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalog the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai and Rodriguez authored an important article, introducing the concept that TEM could be used for the differential diagnosis of histologically similar neoplasms. This publication heralded the steadily increasing application of TEM in anatomic pathology over the following decade, including continuing contributions by Dr. Juan Rosai. This brief review summarizes his influence on clinical electron microscopy, and lists some of the lesions for which that procedure is still a useful means of analysis.

  20. Sea level Variability and Juan de Fuca Bathymetry

    NASA Astrophysics Data System (ADS)

    Huybers, P. J.; Boulahanis, B.; Proistosescu, C.; Langmuir, C. H.; Carbotte, S. M.; Katz, R. F.

    2015-12-01

    That deglaciation influences mid-ocean ridge volcanism is well established for Iceland, where depressurization associated with melting a ~2 km ice cap led to order of magnitude increases in volcanism during the last deglaciation. The case was also made that the more subtle ~100 m changes in sea level that accompany glacial cycles have identifiable implications for undersea mid-ocean ridge systems using both models and data from the Australian-Antarctic Ridge (Crowley et al., 2015). Sea level rising at ~1 cm/year during deglaciation leads to an expectation of ~10% decreases in melt production at ridges, given mantle upwelling rates of ˜3 cm/yr at intermediate spreading ridges and mantle density being ~3 times that of seawater. The implications of variations in melt production for bathymetry, however, involve numerous considerations, including whether melt signals are cancelled within the melt column, appreciably alter accretionary or fault processes, and have identifiable surface expressions. Further empirical assessment of bathymetry is thus useful for purposes of confirming patterns and constraining processes. Here we report on spectral analyses of bathymetry recently acquired from the Juan de Fuca ridge between 44°30'N and 45°15'N during the SeaVOICE expedition. Multibeam swath sonar data were acquired with an EM122 sonar insonfiying seafloor to crustal ages of ˜2 ma with 35 m spatial resolution. We examine (1.) the statistical significance of concentrations of bathymetric variability at the 100 ky, 41 ky, and 23 ky periods characteristic of late-Pleistocene sea level variability; (2.) whether sea level responses are primarily at 41 ky periods in crust accreted during the early Pleistocene, when global sea level variations were primarily at this period; and (3.) if sea level responses are superimposed on bathymetry variations or, instead, align with fault features. We also note that Juan de Fuca's proximity to the Cordilleran Ice Sheet implies that regional

  1. The fate of Don Juan: the myth and the man.

    PubMed

    Brockman, D D

    1992-01-01

    The literary character of Don Juan has offered an opportunity to study certain characteristics in an adult man who began a behavior pattern in adolescence that resembled the legendary and mythical Don Juan. Power and dominating control issues were paramount defenses against a narcissistic depression in this man as seen in his relationships with women and in the transference relationship with me. The transference data have been put to use in providing a formulation for an explanation of the phenomena observed. Other clinical data concerning women and some homosexual men are presented in a more abbreviated fashion. This research effort is a retrospective construction of the dynamics that led to this man's neurosis. In my opinion, a self psychological interpretation offers the more felicitous fit than the classic oedipal interpretation. In fact, at first I tried interpretations based on classic oedipal theory--concerning issues of competition with me as father and fear of retaliation and castration--but this strategy resulted in little or no response. More important than symptomatic response, however, the data minimally and weakly supported those interpretations. To be sure, there were and still are competitive and phallic oedipal issues. Moreover, when the patient's mother died, he was drawn into a closer relationship with his father, a relationship accompanied by wishes and fantasies of taking his mother's place. These wishes were quite real, but, as the analysis preceeded, this negative oedipal configuration occupied a much less prominent place in the dynamics. Power and control issues dominated the clinical picture, masking a depression emanating from a deeper narcissistic focus. Interpretation of these narcissistic issues provided my patient with the relief he was seeking, while the main effect of the antidepressant medication was to help him sleep. By giving him something, a deeply seated wish was gratified and was in keeping with an idealized mother

  2. Deglaciation and postglacial timberline in the San Juan Mountains, Colorado

    USGS Publications Warehouse

    Carrara, P.E.; Mode, W.N.; Rubin, M.; Robinson, S.W.

    1984-01-01

    Lake Emma, which no longer exists because of a mining accident, was a tarn in a south-facing cirque near the headwaters of the Animas River in the San Juan Mountains of southwestern Colorado. During the Pinedale glaciation, this area was covered by a large transection glacier centered over the Lake Emma region. Three radiocarbon dates on basal organic sediment from Lake Emma indicate that by ca. 15,000 yr B.P. this glacier, one of the largest in the southern Rocky Mountains, no longer existed. Twenty-two radiocarbon dates on Picea and Abies krummholz fragments in the Lake Emma deposits indicate that from ca. 9600 to 7800 yr B.P., from 6700 to 5600 yr B.P., and at 3100 yr B.P. the krummholz limit was at least 70 m higher than present. These data, in conjunction with Picea:Pinus pollen ratios from both the Lake Emma site and the Hurricane Basin site of J. T. Andrews, P. E. Carrara, F. B. King, and R. Struckenrath (1975, Quaternary Research 5, 173-197) suggest than from ca. 9600 to 3000 yr B.P. timberline in the San Juan Mountains was higher than present. Cooling apparently began ca. 3000 yr B.P. as indicated by decreases in both the percentage of Picea pollen and Picea:Pinus pollen ratios at the Hurricane Basin site (Andrews et al., 1975). Cooling is also suggested by the lack of Picea or Abies fragments younger than 3000 yr B.P. at either the Lake Emma or the Hurricane Basin site. ?? 1984.

  3. CoRoT-7b: SUPER-EARTH OR SUPER-Io?

    SciTech Connect

    Barnes, Rory; Kaib, Nathan A.; Raymond, Sean N.; Greenberg, Richard; Jackson, Brian

    2010-02-01

    CoRoT-7b, a planet about 70% larger than the Earth orbiting a Sun-like star, is the first-discovered rocky exoplanet, and hence has been dubbed a 'super-Earth'. Some initial studies suggested that since the planet is so close to its host star, it receives enough insolation to partially melt its surface. However, these past studies failed to take into consideration the role that tides may play in this system. Even if the planet's eccentricity has always been zero, we show that tidal decay of the semimajor axis could have been large enough that the planet formed on a wider orbit which received less insolation. Moreover, CoRoT-7b could be tidally heated at a rate that dominates its geophysics and drives extreme volcanism. In this case, CoRoT-7b is a 'super-Io' that, like Jupiter's volcanic moon, is dominated by volcanism and rapid resurfacing. Such heating could occur with an eccentricity of just 10{sup -5}. This small value could be driven by CoRoT-7c if its own eccentricity is larger than {approx}10{sup -4}. CoRoT-7b may be the first of a class of planetary super-Ios likely to be revealed by the CoRoT and Kepler spacecraft.

  4. Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation.

    PubMed

    Meneses, A

    2001-01-08

    The 5-HT(6) receptor antagonist Ro-04-6790 or 8-OH-DPAT injection improved learning consolidation on an autoshaping task, while mCPP, scopolamine and dizocilpine decreased the performance. The effect induced by scopolamine, but not that induced by mCPP, was reversed completely by Ro-04-6790, while dizocilpine effect was antagonized partially. Nevertheless, ritanserin or WAY 100635, but not Ro 04-6790, antagonized the 8-OH-DPAT facilitatory effects on learning consolidation. As WAY 100635 did not modify the Ro 04-6790 facilitatory effect, hence 5-HT(1A), and/or 5-HT(7), but not 5-HT(6), receptors might mediate the 8-OH-DPAT facilitatory effect on learning consolidation. Since, the Ro 04-6790 facilitatory effect was unaffected by 5-HT(1A), 5-HT(2A)/(2B)/(2C), 5-HT(3) or 5-HT(4) receptor blockade, thereby, the facilitatory effect induced by Ro 04-6790 involved specifically 5-HT(6) receptors. Indeed, the present data provide further support to the notion that, 5-HT(6) receptors play a significant part in the learning consolidation under normal and dysfunctional memory conditions.

  5. Characterisation of residual ionospheric errors in bending angles using GNSS RO end-to-end simulations

    NASA Astrophysics Data System (ADS)

    Liu, C. L.; Kirchengast, G.; Zhang, K. F.; Norman, R.; Li, Y.; Zhang, S. C.; Carter, B.; Fritzer, J.; Schwaerz, M.; Choy, S. L.; Wu, S. Q.; Tan, Z. X.

    2013-09-01

    Global Navigation Satellite System (GNSS) radio occultation (RO) is an innovative meteorological remote sensing technique for measuring atmospheric parameters such as refractivity, temperature, water vapour and pressure for the improvement of numerical weather prediction (NWP) and global climate monitoring (GCM). GNSS RO has many unique characteristics including global coverage, long-term stability of observations, as well as high accuracy and high vertical resolution of the derived atmospheric profiles. One of the main error sources in GNSS RO observations that significantly affect the accuracy of the derived atmospheric parameters in the stratosphere is the ionospheric error. In order to mitigate the effect of this error, the linear ionospheric correction approach for dual-frequency GNSS RO observations is commonly used. However, the residual ionospheric errors (RIEs) can be still significant, especially when large ionospheric disturbances occur and prevail such as during the periods of active space weather. In this study, the RIEs were investigated under different local time, propagation direction and solar activity conditions and their effects on RO bending angles are characterised using end-to-end simulations. A three-step simulation study was designed to investigate the characteristics of the RIEs through comparing the bending angles with and without the effects of the RIEs. This research forms an important step forward in improving the accuracy of the atmospheric profiles derived from the GNSS RO technique.

  6. Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease.

    PubMed Central

    Yacyshyn, B R; Pilarski, L M

    1993-01-01

    Crohn's disease is an immunoregulatory disorder of the intestine that can be associated with systemic manifestations. This study analysed B-cell differentiation antigens to identify B-cell subpopulations unique to patients with Crohn's disease. CD45 isoform expression was used as an indicator of B-cell differentiation stage. This work shows that B-cells in blood and gut of patients with Crohn's disease are at an advanced stage of differentiation based on their unusual presentation of transitional (RA+ RO+) and late stage (RO+)CD45 isoforms on lamina propria lymphocytes, whereas normal intestinal lamina propria lymphocytes B-cells express primarily CD45RA. Crohn's disease patients had heightened expression of the CD45RO isoform on CD19+ lamina propria lymphocytes, and was found in a statistically significant proportion of Crohn's peripheral blood mononuclear cells (PBMC) where CD19+ PBMC had an expression pattern affecting an unexpectedly high proportion of these differentiated or late stage CD45RO+ B-cells. The expression of CD45RO varied greatly among CD19+ PBMC from patients with Crohn's disease, so multiple regression analysis was performed between these CD45 isoforms and several clinical parameters. After grouping high and low CD45RO expression on CD19+ B-cells, a significant statistical difference was found between high Crohn's disease activity index (CDAI) and low CDAI Crohn's disease patients respectively. PMID:7506695

  7. Letter to Silverton and San Juan County Regarding Potential Superfund Listing

    EPA Pesticide Factsheets

    Feb. 12, 2016 Update: EPA added a letter to the Town of Silverton and San Juan County regarding the agency’s commitment to the Town and County’s involvement during a potential Superfund listing process.

  8. Juan de Fuca plate: Aseismic subduction at 1. 8 cm/yr

    SciTech Connect

    Acharya, H.

    1981-11-01

    Volcanic activity in the Cascades in historic times suggests that the Juan de Fuca plate is underthrusting aseismically at about 1.8 cm/yr. This rate of underthrusting is identical to the rate computed from sediment studies.

  9. Don Juan Basin, Wright Valley, Antarctica: Model for Surface Processes on Mars

    NASA Astrophysics Data System (ADS)

    Englert, P.; Bishop, J. L.; Gibson, E. K.; Patel, S.; Koeberl, C.

    2014-09-01

    Mineral, chemical, and soluble salt composition of drill core samples from Don Juan Basin, Wright Valley, Antarctica, indicate that the formation of the most saline terrestrial pond may include groundwater discharge and near surface flow processes.

  10. Hydrologic data for the San Juan and Animas River valleys in the Farmington, Aztec, Bloomfield, and Cedar Hill areas, San Juan County, New Mexico

    USGS Publications Warehouse

    McAda, D.P.; Shelton, S.G.

    1987-01-01

    In July 1985, the U.S. Geological Survey initiated a three-year study in San Juan County, New Mexico, to determine the concentrations of chemical constituents in the groundwater in the San Juan and Animas River valleys and to determine the direction and rate of groundwater flow and its relation to river stage. The study was conducted in cooperation with the San Juan County Commission and the New Mexico Oil Conservation Division. The data that was collected during the first 1-1/2 yr of the study is completed. The report includes well records for 51 wells and water levels from 23 wells, hydrographs from four observation wells and one river stage site, and available chemical analyses from 50 wells and 14 surface water sites. Water samples from six wells and one surface-water site were analyzed for purgeable organic chemicals; none were detected. (Lantz-PTT)

  11. Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa.

    PubMed

    Santel, A; Blümer, N; Kämpfer, M; Renkawitz-Pohl, R

    1998-11-01

    The Drosophila don juan gene encodes a basic protein (Don Juan protein), which is solely expressed postmeiotically during spermiogenesis in elongated spermatids and in mature sperm. Transgenic expression of a GFP-tagged Don Juan protein (DJ-GFP) in the male germ line showed an association of the fusion protein with the sperm tail. Detailed examination of DJ-GFP localization revealed novel insights into its distinct temporal and spatial distribution along the sperm tail during the last phase of spermatid maturation. Co-localization of DJ-GFP with actin-labeled cysts demonstrated its emergence in elongated spermatids during individualization. Additionally, the endogenous Don Juan protein was detected with epitope-specific antibodies in finally elongated nuclei of spermatids. After completion of nuclear shaping Don Juan is no longer detectable in the sperm heads with the onset of individualization. Mislocalization of the DJ-GFP protein in flagella of a mutant with defective mitochondrial differentiation provides evidence of mitochondrial association of the fusion protein with flagellar mitochondrial arrays. Ectopically expressed DJ-GFP in premeiotic germ cells as well as salivary gland cells confirmed the capability of the fusion protein to associate with mitochondria. Therefore we suppose that Don Juan is a nuclear-encoded, germ-cell specifically expressed mitochondrial protein, which might be involved in the final steps of mitochondrial differentiation within the flagellum.

  12. Increasing RO efficiency by chemical-free ion-exchange and Donnan dialysis: Principles and practical implications.

    PubMed

    Vanoppen, Marjolein; Stoffels, Griet; Demuytere, Célestin; Bleyaert, Wouter; Verliefde, Arne R D

    2015-09-01

    Ion-exchange (IEX) and Donnan dialysis (DD) are techniques which can selectively remove cations, limiting scaling in reverse osmosis (RO). If the RO concentrate could be recycled for regeneration of these pre-treatment techniques, RO recovery could be largely increased without the need for chemical addition or additional technologies. In this study, two different RO feed streams (treated industrial waste water and simple tap water) were tested in the envisioned IEX-RO and DD-RO hybrids including RO concentrate recycling. The efficiency of multivalent cation removal depends mainly on the ratio of monovalent to multivalent cations in the feed stream, influencing the ion-exchange efficiency in both IEX and DD. Since the mono-to-multivalent ratio was very high in the waste water, the RO recovery could potentially be increased to 92%. For the tap water, these high RO recoveries could only be reached by adding additional NaCl, because of the low initial monovalent to multivalent ratio in the feed. In both cases, the IEX-RO hybrid proved to be most cost-efficient, due to the high current cost of the membranes used in DD. The membrane cost would have to decrease from ±300 €/m² to 10-30 €/m² - comparable to current reverse osmosis membranes - to achieve a comparable cost. In conclusion, the recycling of RO concentrate to regenerate ion exchange pre-treatment techniques for RO is an interesting option to increase RO recovery without addition of chemicals, but only at high monovalent/multivalent cation-ratios in the feed stream.

  13. MBR/RO/ozone processes for TFT-LCD industrial wastewater treatment and recycling.

    PubMed

    Chen, T K; Ni, C H; Chan, Y C; Lu, M C

    2005-01-01

    This research is mainly to explore the treatment capacity for TFT-LCD industrial wastewater recycling by the processes combined with membrane bioreactor (MBR), reverse osmosis (RO) and ozone(O3). The organic wastewater from the TFT-LCD industry was selected as the target. MBR, RO and ozone plants were established for evaluation. An MBR plant consisted of a 2-stage anoxic/aerobic bioreactor and an immersed UF membrane unit was employed. The effluent of MBR was conducted into the RO system then into the ozone system. The RO system consisted of a spiral membrane in the vessel. One bubble column, 75 cm high and diameter 5 cm, were used as the ozonation reactor. On the bottom of ozonation reactor is a porous diffuser for releasing gas, with an aperture of 100 microm (0.1 cm). Over the whole experimental period, the MBR process achieved a satisfactory organic removal. The COD could be removed with an average of over 98.5%. For the TOC item, the average removal efficiency was 97.4%. The stable effluent quality and satisfactory removal performance were ensured by the efficient interception performance of an immersed UF membrane device incorporated with the biological reactor. Moreover, the MBR effluent did not contain any suspended solids and the SDI value was under 3. After the treatment of RO, excellent water quality was found. The water quality of permeate was under 5 mg/I, 2 mg/l and 50 micros/cm for COD, TOC and conductivity respectively. The treated water can be recycled and reused for the cooling tower make-up water or other purposes. After the treatment of ozone, the treated water quality was under 5 mg/l and 0.852 mg/l for COD and TOC respectively. The test results of MBR, MBR/RO and MBR/RO/ozone processes were compared as possible appropriate treatment technologies applied in TFT-LCD industrial wastewater reuse and recycling.

  14. Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

    PubMed

    Klotz, U; Ziegler, G; Rosenkranz, B; Mikus, G

    1986-11-01

    Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subsequently to an oral loading dose (0.54 g ethanol kg-1) ethanol was infused for 4 h (0.15 g ethanol kg-1 h-1) and steady state blood levels between 0.9 to 1.2 g l-1 were reached within 2 h. At steady state and during the elimination phase of ethanol an intravenous bolus of 0.5 mg Ro 15-1788 or placebo was administered in a randomized, double-blind crossover fashion. The marked sedative effects of ethanol as assessed by visual analogue scales (2 to 6 fold increase in the sedation index), and choice reaction time (25 to 40% prolongation) were not affected by Ro 15-1788. However, the pharmaco-EEG indicated that Ro 15-1788 seems to reverse transiently the ethanol-induced changes in total alpha, delta, and slow alpha bands. There was no pharmacokinetic interaction between both agents since elimination of Ro 15-1788 (t1/2 = 1.2 +/- 0.7 h) and of ethanol (0.17 +/- 0.02 g l-1 h-1) were in good agreement with control values. Thus, it could be concluded that Ro 15-1788 might affect for a short while the action of ethanol by interfering with the benzodiazepine receptors.

  15. Relation of Sensory Peripheral Neuropathy in Sjögren Syndrome to anti-Ro/SSA

    PubMed Central

    Scofield, Amanda K.; Radfar, Lida; Ice, John; Vista, Evan; Anaya, Juan-Manuel; Houston, Glen; Lewis, David; Stone, Donald U.; Chodosh, James; Hefner, Kimberly; Lessard, Christopher J.; Moser, Kathy L.; Scofield, R. Hal

    2013-01-01

    Background Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods Eight-eight patients attending a dry eyes-dry mouth clinic were classified as primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ2=8.46, p=0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) of these had neuropathy (χ2 =5.587, p=0.018 compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusion Sensory peripheral neuropathy is common among patients with Sjögren syndrome, and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion. PMID:22955477

  16. Investigating the Relationship between Fin and Blue Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2011-09-30

    Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography...OBJECTIVES We are continuing a study of seismic and bio-acoustical data sets from the Juan de Fuca Ridge with the following three objectives for FY2011...Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

  17. Investigating the Relationship Between Fin and Blue Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2009-09-30

    Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography University...We are conducting a retrospective study using existing seismic and bio-acoustical data sets from the Juan de Fuca Ridge with the following four...Investigating The Relationship Between Fin And Blue Whale Locations, Zooplankton Concentrations And Hydrothermal Venting On The Juan de Fuca Ridge 5a. CONTRACT

  18. Investigating the Relationship Between Fin and Blue Whale Locations, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2008-01-01

    Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography University of Washington Box...between whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de Fuca Ridge with the long-term goal of understanding...conducting a retrospective study using existing seismic and bio-acoustical data sets from the Juan de Fuca Ridge with the following four objectives

  19. RoBlock: a prototype autonomous manufacturing cell

    NASA Astrophysics Data System (ADS)

    Baekdal, Lars K.; Balslev, Ivar; Eriksen, Rene D.; Jensen, Soren P.; Jorgensen, Bo N.; Kirstein, Brian; Kristensen, Bent B.; Olsen, Martin M.; Perram, John W.; Petersen, Henrik G.; Petersen, Morten L.; Ruhoff, Peter T.; Skjolstrup, Carl E.; Sorensen, Anders S.; Wagenaar, Jeroen M.

    2000-10-01

    RoBlock is the first phase of an internally financed project at the Institute aimed at building a system in which two industrial robots suspended from a gantry, as shown below, cooperate to perform a task specified by an external user, in this case, assembling an unstructured collection of colored wooden blocks into a specified 3D pattern. The blocks are identified and localized using computer vision and grasped with a suction cup mechanism. Future phases of the project will involve other processes such as grasping and lifting, as well as other types of robot such as autonomous vehicles or variable geometry trusses. Innovative features of the control software system include: The use of an advanced trajectory planning system which ensures collision avoidance based on a generalization of the method of artificial potential fields, the use of a generic model-based controller which learns the values of parameters, including static and kinetic friction, of a detailed mechanical model of itself by comparing actual with planned movements, the use of fast, flexible, and robust pattern recognition and 3D-interpretation strategies, integration of trajectory planning and control with the sensor systems in a distributed Java application running on a network of PC's attached to the individual physical components. In designing this first stage, the aim was to build in the minimum complexity necessary to make the system non-trivially autonomous and to minimize the technological risks. The aims of this project, which is planned to be operational during 2000, are as follows: To provide a platform for carrying out experimental research in multi-agent systems and autonomous manufacturing systems, to test the interdisciplinary cooperation architecture of the Maersk Institute, in which researchers in the fields of applied mathematics (modeling the physical world), software engineering (modeling the system) and sensor/actuator technology (relating the virtual and real worlds) could

  20. From CoRoT 102899501 to the Sun. A time evolution model of chromospheric activity on the main sequence

    NASA Astrophysics Data System (ADS)

    Gondoin, P.; Gandolfi, D.; Fridlund, M.; Frasca, A.; Guenther, E. W.; Hatzes, A.; Deeg, H. J.; Parviainen, H.; Eigmüller, P.; Deleuil, M.

    2012-12-01

    , inferred using a parameterization of the stellar rotation period as a function of colour index and time established for the I-sequence of stars in stellar clusters. Conclusions: We conclude that the high magnetic activity level and fast rotation of CoRoT 102899501 are manifestations of its stellar youth consistent with its estimated evolutionary status and with the detection of a strong Li i λ6707.8 Å absorption line in its spectrum. We argue that a magnetic activity level comparable to that observed on CoRot 102899501 could have been present on the Sun at the time of planet formation. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain.Based on observations made with the Anglo-Australian Telescope; the 2.1-m Otto Struve telescope at McDonald Observatory, Texas, USA; the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias, in time allocated by the NOT "Fast-Track" Service Programme, OPTICON, and the Spanish Time Allocation Committee (CAT).The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number RG226604 (OPTICON).

  1. The end stage of dialysis access: femoral graft or HeRO vascular access device.

    PubMed

    Kudlaty, Elizabeth A; Pan, Jeanne; Allemang, Matthew T; Kendrick, Daniel E; Kashyap, Vikram S; Wong, Virginia L

    2015-01-01

    Maintaining and establishing vascular access in end-stage renal disease (ESRD) patients is complicated when they are poor candidates for traditional upper extremity access. Our objective was to compare our experience with 2 alternative dialysis accesses, the femoral arteriovenous graft (fAVG) and the Hemodialysis Reliable Outflow (HeRO), in patients with limited remaining options. A single institution, retrospective review of ESRD patients with fAVG or HeRO placed between May 2009 and February 2013 was performed. Adult patients were selected by reviewing all arteriovenous grafts placed at a single institution. Patient demographics, medical history, access characteristics, and outcomes were recorded from both institutional and dialysis center databases. Data were evaluated using Fisher's exact test, unpaired t-test for continuous variables, log-rank test, and univariate analysis. A total of 56 accesses in 43 unique patients met these criteria: 35 fAVG and 21 HeRO; with 1 HeRO patient lost immediately to follow-up. Clinical variables were similar except the HeRO group had more diabetic patients (60% HeRO, 22.9% fAVG; P = 0.01). The average number of years on hemodialysis was 7.0 ± 1.0 for fAVG and 5.7 ± 0.9 for HeRO (P = 0.41). Primary patency was 40.5%, 18.7%, and 14.9% for fAVG and 29.0%, 29.0%, and 0% for HeRO at 6 months, 12 months, and 2 years (P = 0.67), respectively. Assisted primary patency was also similar, with 43.8%, 29.4%, and 13.8% for fAVG and 34.8%, 34.8%, and 17.4% for HeRO at 6 months, 12 months, and 2 years (P = 0.81), respectively. Secondary patency was 62.6%, 50.6%, 19.3% for fAVG and 68.0%, 53.5%, 38.3% for HeRO at 6 months, 12 months, and 2 years (P = 0.69), respectively. Average number of interventions to maintain patency for fAVG was 1.1 ± 1.47 and 1.65 ± 2.52 for HeRO (P = 0.35). Infectious complications occurred in 29% of fAVG and 15% of HeRO (P = 0.33). Patients who received either fAVG or HeRO experience poor access patency. ESRD

  2. Linc-RoR promotes c-Myc expression through hnRNP I and AUF1

    PubMed Central

    Huang, Jianguo; Zhang, Ali; Ho, Tsui-Ting; Zhang, Ziqiang; Zhou, Nanjiang; Ding, Xianfeng; Zhang, Xu; Xu, Min; Mo, Yin-Yuan

    2016-01-01

    Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in humans and it has also been implicated in tumorigenesis. However, the underlying mechanism of Linc-RoR-mediated gene expression in cancer is poorly understood. The present study demonstrates that Linc-RoR plays an oncogenic role in part through regulation of c-Myc expression. Linc-RoR knockout (KO) suppresses cell proliferation and tumor growth. In particular, Linc-RoR KO causes a significant decrease in c-Myc whereas re-expression of Linc-RoR in the KO cells restores the level of c-Myc. Mechanistically, Linc-RoR interacts with heterogeneous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1), respectively, with an opposite consequence to their interaction with c-Myc mRNA. While Linc-RoR is required for hnRNP I to bind to c-Myc mRNA, interaction of Linc-RoR with AUF1 inhibits AUF1 to bind to c-Myc mRNA. As a result, Linc-RoR may contribute to the increased stability of c-Myc mRNA. Although hnRNP I and AUF1 can interact with many RNA species and regulate their functions, with involvement of Linc-RoR they would be able to selectively regulate mRNA stability of specific genes such as c-Myc. Together, these results support a role for Linc-RoR in c-Myc expression in part by specifically enhancing its mRNA stability, leading to cell proliferation and tumorigenesis. PMID:26656491

  3. Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508)

    SciTech Connect

    Maughan, T.S.; Newman, H.F.; Bleehen, N.M.; Ward, R.; Workman, P. )

    1990-05-01

    The hypoxic cell radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole) are under evaluation as single agents (Phase III) and in combination (Phase I). Ro 03-8799 produces an acute, transient central nervous system syndrome, whereas SR 2508 causes cumulative, peripheral neurotoxicity; both effects are dose-limiting. Pharmacokinetic studies have shown the importance of area under the plasma drug concentration versus time curve (AUC) in predicting the risk of peripheral neuropathy. Most patients have very similar pharmacokinetic parameters. This study reports 2/25 patients receiving 0.75 g/m2 Ro 03-8799 plus 2.0 g/m2 SR 2508 who showed significant discrepancies in drug handling. One patient exhibited a markedly elevated AUC and prolonged t1/2 beta for SR 2508 and this was associated with an unusually rapid onset of peripheral neuropathy. A second patient showed normal handling of SR 2508 but prolonged values for both t1/2 alpha and t1/2 beta for Ro 03-8799 and unusually low levels of its N-oxide metabolite. In addition a low peak Ro 03-8799 concentration combined with a very high volume of distribution was found in this patient, leading to a normal AUC value and toxicity profile. Both patients exhibited a relatively low creatinine clearance. The mechanisms which may underlie these findings are discussed, and the importance of pharmacokinetic monitoring in the use of these agents is emphasized.

  4. Transpiration Rate for Chile Peppers Irrigated with Brackish Groundwater and ro Concentrate

    NASA Astrophysics Data System (ADS)

    Shukla, M. K.; Baath, G.

    2016-12-01

    Fresh water availability is declining in most of the semi-arid and arid regions across the world including southwestern United States. Use of marginal quality groundwater has been increasing for sustaining agriculture in these arid regions. Reverse Osmosis (RO) can treat brackish groundwater but the possibility of using RO concentrate for irrigation needs further exploration. This greenhouse study evaluates the transpiration rate, water use, leaching fraction and yield responses of five selected chile pepper (Capsicum annuum) cultivars irrigated with natural brackish groundwater and RO concentrate. The four saline water treatments used for irrigation were tap water of EC 0.6 (control), ground water of EC 3 and 5 dS/m and RO concentrate of EC 8 dS/m. The transpiration of all chile peppers cultivars decreased and leaching fraction increased with increasing irrigation water salinity. Based on the water use efficiency (WUEY) of selected chile pepper cultivars, brackish water of EC ≤ 3 dS/m can be used for irrigation. The average yield of chile peppers was stable up to a saturated soil paste extract electrical conductivity (ECe) of about 2 dS/m, although further increases in ECe resulted in an exponential yield decline. This study showed that yield reductions in chile peppers irrigated with Ca rich brackish groundwater were less than those reported using NaCl dominant saline solution studies. Environmentally safe reuse of RO concentrate could stimulate implementation of inland desalination in water scarce areas and increase greenhouse chile pepper cultivation.

  5. Speckle Imaging of Kepler and CoRoT Exo-planet Transit Candidate Stars

    NASA Astrophysics Data System (ADS)

    Howell, Steve B.; Horch, Elliott; Sherry, William; Ciardi, David

    2010-08-01

    Kepler and CoRoT are complementary space missions dedicated to the detection of exoplanets. The primary science goal of CoRoT is to find Neptune-sized (>3 Earth radii) planets in intermediate orbits, while the prime science goal of Kepler is to find Earth-sized planets (<3 Earth radii) in year-long orbits. Both missions employ the photometric transit method and both spacecraft are performing well with nominal operation of the spacecraft, telescopes, electronics, and instruments. As with ground-based surveys, Kepler and CoRoT candidates need to be screened for background eclipsing binary stars which, when photometrically blended with the primary target, can mimic exo-planetary transits. The list of candidate transiting planets found by Kepler/CoRoT requires follow-up to ascertain probable or certain exo- planet detection. While Earth-sized (and Neptune-sized in long orbital periods) exo-planets can not currently (easily) be confirmed from the ground, many of the false positive eliminations steps can be performed by ground-based observations. Follow-up for Kepler exo-planet candidates is now aimed at Neptune-size and smaller planets in longer period orbits. This proposal aims to obtain high resolution speckle imaging to observe Kepler/CoRoT exo-planet transit candidates in order to eliminate the largest false positive contributor in any transit search - background eclipsing binary stars or faint companion stars.

  6. Data Analysis Provenance: Use Case for Exoplanet Search in CoRoT Database

    NASA Astrophysics Data System (ADS)

    de Souza, L.; Salete Marcon Gomes Vaz, M.; Emílio, M.; Ferreira da Rocha, J. C.; Janot Pacheco, E.; Carlos Boufleur, R.

    2012-09-01

    CoRoT (COnvection Rotation and Planetary Transits) is a mission led by the French national space agency CNES, in collaboration with Austria, Spain, Germany, Belgium and Brazil. The mission priority is dedicated to exoplanet search and stellar seismology. CoRoT light curves database became public after one year of their delivery to the CoRoT Co-Is, following the CoRoT data policy. The CoRoT archive contains thousands of light curves in FITS format. Several exoplanet search algorithms require detrend algorithms to remove both stellar and instrumental signal, improving the chance to detect a transit. Different detrend and transit detection algorithms can be applied to the same database. Tracking the origin of the information and how the data was derived in each level in the data analysis process is essential to allow sharing, reuse, reprocessing and further analysis. This work aims at applying a formalized and codified knowledge model by means of domain ontology. It allows to enrich the data analysis with semantic and standardization. It holds the provenance information in the database for a posteriori recovers by humans or software agents.

  7. Anti-Ro/SSA antibodies and cardiac arrhythmias in the adult: facts and hypotheses.

    PubMed

    Lazzerini, P E; Capecchi, P L; Laghi-Pasini, F

    2010-09-01

    It is well established that the passive trans-placental passage of anti-Ro/SSA antibodies from mother to foetus is associated with the risk to develop an uncommon syndrome named neonatal lupus (NLE), where the congenital heart block represents the most severe clinical feature. Recent evidence demonstrated that also adult heart, classically considered invulnerable to the anti-Ro/SSA antibodies, may represent a target of the arrhythmogenicity of these autoantibodies. In particular, the prolongation of the QTc interval appears the most frequent abnormality observed in adults with circulating anti-Ro/SSA antibodies, with some data suggesting an association with an increased risk of ventricular arrhythmias, also life threatening. Moreover, even though the association between anti-Ro/SSA antibodies and conduction disturbances is undoubtedly less evident in adults than in infants, from the accurate dissection of the literature data the possibility arises that sometimes also the adult cardiac conduction tissue may be affected by such antibodies. The exact arrhythmogenic mechanisms involved in foetus/newborns and adults, respectively, have not been completely clarified as yet. However, increasing evidence suggests that anti-Ro/SSA antibodies may trigger rhythm disturbances through an inhibiting cross-reaction with several cardiac ionic channels, particularly the calcium channels (L-type and T-type), but also the potassium channel hERG, whose different expression and involvement in the cardiac electrophysiology during lifespan might account for the occurrence of age-related differences.

  8. The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma

    PubMed Central

    Segura, Miguel F.; Medicherla, Ratna; Haimovic, Adele; Menendez, Silvia; Shang, Shulian; Pavlick, Anna; Shao, Yongzhao; Darvishian, Farbod; Boylan, John F.; Osman, Iman; Hernando, Eva

    2011-01-01

    Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097, a novel inhibitor of gamma secretase, which is a key component of the enzymatic complex that cleaves and activates NOTCH. The effects of RO4929097 on the oncogenic and stem cell properties of a panel of melanoma cell lines were tested both in vitro and in vivo, using xenograft models. In human primary melanoma cell lines, RO4929097 decreased the levels of NOTCH transcriptional target HES1. This was accompanied by reduced proliferation and impaired ability to form colonies in soft agar and to organize in tridimensional spheres. Moreover, RO4929097 affected the growth of human primary melanoma xenograft in NOD/SCID/IL2gammaR-/- mice and inhibited subsequent tumor formation in a serial xenotransplantation model, suggesting that inhibition of NOTCH signaling suppresses the tumor initiating potential of melanoma cells. In addition, RO4929097 decreased tumor volume and blocked the invasive growth pattern of metastatic melanoma cell lines in vivo. Finally, increased gene expression of NOTCH signaling components correlated with shorter post recurrence survival in metastatic melanoma cases. Our data support NOTCH inhibition as a promising therapeutic strategy against melanoma. PMID:21980408

  9. Foulant Analysis of Three RO Membranes Used in Treating Simulated Brackish Water of the Iraqi Marshes

    PubMed Central

    Sachit, Dawood Eisa; Veenstra, John N.

    2017-01-01

    In this work, three different types of Reverse Osmosis (RO) (Thin-Film Composite (SE), Cellulose Acetate (CE), and Polyamide (AD)) were used to perform foulant analysis (autopsy) study on the deposited materials from three different simulated brackish surface feed waters. The brackish surface water qualities represented the water quality in Iraqi marshes. The main foulants from the simulated feed waters were characterized by using Scanning Electron Microscope (SEM) images and Energy-Dispersive X-ray Spectroscopy (EDXS) spectra. The effect of feed water temperatures (37 °C and 11 °C) on the formation of the fouled material deposited on the membrane surface was examined in this study. Also, pretreatment by a 0.1 micron microfiltration (MF) membrane of the simulated feed water in advance of the RO membrane on the precipitated material on the membrane surface was investigated. Finally, Fourier Transform Infrared Spectroscopy (FTIR) analysis was used to identify the functional groups of the organic matter deposited on the RO membrane surfaces. The SEM images and EDSX spectra suggested that the fouled material was mainly organic matter, and the major crystal deposited on the RO membrane was calcium carbonate (CaCO3). The FTIR spectra of the fouled RO membranes suggested that the constituents of the fouled material included aliphatic and aromatic compounds. PMID:28406468

  10. RO-ILS: Radiation Oncology Incident Learning System: A report from the first year of experience.

    PubMed

    Hoopes, David J; Dicker, Adam P; Eads, Nadine L; Ezzell, Gary A; Fraass, Benedick A; Kwiatkowski, Theresa M; Lash, Kathy; Patton, Gregory A; Piotrowski, Tom; Tomlinson, Cindy; Ford, Eric C

    2015-01-01

    Incident learning is a critical tool to improve patient safety. The Patient Safety and Quality Improvement Act of 2005 established essential legal protections to allow for the collection and analysis of medical incidents nationwide. Working with a federally listed patient safety organization (PSO), the American Society for Radiation Oncology and the American Association of Physicists in Medicine established RO-ILS: Radiation Oncology Incident Learning System (RO-ILS). This paper provides an overview of the RO-ILS background, development, structure, and workflow, as well as examples of preliminary data and lessons learned. RO-ILS is actively collecting, analyzing, and reporting patient safety events. As of February 24, 2015, 46 institutions have signed contracts with Clarity PSO, with 33 contracts pending. Of these, 27 sites have entered 739 patient safety events into local database space, with 358 events (48%) pushed to the national database. To establish an optimal safety culture, radiation oncology departments should establish formal systems for incident learning that include participation in a nationwide incident learning program such as RO-ILS. Copyright © 2015 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

  11. 78 FR 19103 - Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Spanish Navy School Ship San Sebastian El.... Add Sec. 165.T07-0166 to read as follows: Sec. 165.T07-0166 Safety Zone, Spanish Navy School Ship San.... SUMMARY: The Coast Guard is establishing a temporary moving safety zone on the waters of Bahia de San Juan...

  12. Distribution of geothermal fields on the Juan De Fuca ridge

    SciTech Connect

    Crane, K.; Aikman F. III; Embley, R.; Hammond, S.; Malahoff, A.; Lupton, J.

    1985-01-10

    Near bottom water temperatures were mapped along 400 km of the strike of the Juan de Fuca Ridge as part of a combined Sea MARC/Seabeam experiment to image the variability of morphology and structure along a spreading center segment. The water temperature data collected by a continuously towed thermistor chain, in addition to salinity data, indicate that there are four geothermal areas spaced at distances of 100 km from each other south of the Cobb propagator and one field just to the north of the propagator on the Endeavor Ridge segment. Each thermal region is located above a morphological dome on the spreading center. These domes are an average of 100--200 m shallower than the rest of the axis. The structure of bottom water suggests that the geothermal regions are on average 20 km long and that the heat from these fields raises the temperature in the water column by a minimum of 0.06/sup 0/C up to 300 m above the bottom. Two simple models are used to estimate the heat flux associated with these features.

  13. San Juan basin faulting - More than meets eye

    SciTech Connect

    Huffman, A.C. Jr.; Taylor, D.J. )

    1989-09-01

    Interpretation of approximately 1,000 mi of seismic lines throughout the San Juan basin, New Mexico, has revealed a rectilinear pattern of high-angle faults with dominant trends of N60-70{degree}W and N30-40{degree}E. Vertical fault separation in the plane of section is commonly 150-250 ft, measured at the top of the basement. Strike-slip movement on many faults is also indicated by the map pattern, but no reliable measurements have yet been made. The authors analysis of the movement history of several faults indicates three significant episodes of movement: Pennsylvanian to Permian, Jurassic to Cretaceous, and early to middle Tertiary. Sense of movement on many of the faults varied episodically so that the present basement offset is actually cumulative offset representing all previous periods of movement. Above Permian strata, actual offset on most faults is not detectable on seismic sections; however, drape and measurable differences in thickness across fault zones are commonly exhibited by Mesozoic rocks.

  14. Basalt Geochemistry of the Endeavour Segment, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Woodcock, J. P.; Gill, J.; Kela, J.; Michael, P.; Ramos, F.

    2006-12-01

    We present new trace element, volatile, isotope, and modeling data for mid-ocean ridge basalts (MORB) from the Endeavour Axial Ridge Volcano (EARV) segment of the Juan de Fuca Ridge. Endeavour MORB are categorized to a first order using K2O/TiO2, with T-MORB = 0.15-0.25, N-MORB lower, and E- MORB higher. Within these groups, there are 2 subgroups of N-MORB and 3 of T-MORB, distinguished by differences in Si8, Fe8, Ti8, and differentiation paths. Liquid lines of descent are best explained by crystallization within the crust at measured water contents (0.2-0.5 wt. %). EARV basalts exhibit spatial heterogeneities that far exceed what can be explained by these fractional crystallization models. Incompatible trace element ratios such as Zr/Nb, La/Yb, and K2O/TiO2 exhibit 3- to 4-fold variations, indicating heterogeneity of source or melting processes. The heterogeneity is observed along axis in samples only tens to hundreds of meters apart and is most prominent along the western wall of the axial valley, suggesting that axial magma chambers may be short-lived. Despite their heterogeneity, axial samples have nearly constant 87Sr/86Sr and ^{143}Nd/^{144}Nd ratios. Pb isotopes are more variable (206Pb/204Pb = 18.35-18.90). The heterogeneity seems unrelated to the chemical influence of a plume or the thermal perturbations of a transform fault.

  15. Fruit and fertility in San Juan de la Manguana.

    PubMed

    Mckenna, N D

    1995-01-01

    Ana Irsa (Nisoris) Aquina, 39, a mother of seven, grandmother, wife, and voluntary community health facilitator, lives in the Dominican Republic. Nisoris counsels women and their partners about reproductive health, provides child survival information to new mothers, and dispenses common remedies for diarrhea and respiratory infections as well as contraceptives (mainly oral contraceptives and condoms). These supplies are financed by Fundacion para el Desarrollo Communitario (FUDECO), a nongovernmental agency which is a member of the Save the Children alliance. FUDECO's work includes the development of water systems, health services, schools, and soil conservation training. Widespread deforestation in the San Juan area has led to a reduction in self-sufficient farming and a lack of nutrition evidenced by an increase in infant blindness caused by Vitamin A deficiency. To combat this situation, FUDECO has taught the women's group led by Nisoris how to use solar power to dry fruits and vegetables to preserve them for consumption beyond their season. The pilot group has in turn taught six other women's groups and conducted informal product sampling and Vitamin A information sessions in the local market. FUDECO provides supplies and technical expertise. The program has been so successful that the women are exploring packaging options so that they can sell the dried produce.

  16. WE-B-Exhibit Hall-01: Ask the RO-ILS Experts

    SciTech Connect

    Ezzell, G; Sanscrainte, E; Tomlinson, C

    2015-06-15

    Have a question about RO-ILS: Radiation Oncology Incident Learning System™, or interested in learning more? Sponsored by the American Society for Radiation Oncology (ASTRO) and AAPM, RO-ILS is the only medical specialty society-sponsored incident learning system for radiation oncology. It facilitates safer and higher quality care in radiation oncology by providing a mechanism for shared learning in a secure and non-punitive environment. Please join our RO-ILS experts for a question and answer session on Wednesday, July 15th at 8:30 in the Partners in Solutions Room in Exhibit Hall C. Our experts include: Gary Ezzell, PhD, Mayo Clinic Arizona, [Brett Miller, Phillip Beron, and Derek Brown], Emily Sanscrainte from Clarity PSO and Cindy Tomlinson, MPP, ASTRO.

  17. Local rotundity structure of Cesàro-Orlicz sequence spaces

    NASA Astrophysics Data System (ADS)

    Foralewski, Pawel; Hudzik, Henryk; Szymaszkiewicz, Alicja

    2008-09-01

    Some criteria for extreme points and strong U-points in Cesàro-Orlicz spaces are given. In consequence we find a Cesàro-Orlicz sequence space different from c0 which has no extreme points. Some examples show that in these spaces the notion of the strong U-point is essentially stronger than the notion of the extreme point. Various examples presented in this paper show that there are some differences between criteria for extreme points and strong U-points in Orlicz spaces and in Cesàro-Orlicz spaces. We also show that the uniqueness of the local best approximation needs the notion of SU-point, that is, the notion of the extreme point is not strong enough here.

  18. On the spectrum of the Cesàro operator on spaces of analytic functions

    NASA Astrophysics Data System (ADS)

    Persson, Anna-Maria

    2008-04-01

    This paper concerns the Cesàro operator acting on various spaces of analytic functions on the unit disc. The remarkable fact that this operator is subnormal when acting on the Hardy space H2 has lead to extensive studies of its spectral picture on other spaces of this type. We present some of the methods that have been used to obtain information about the spectrum of the Cesàro operator acting on Hardy and Bergman spaces and give a unified approach to these problems which also yields new results in this direction. In particular, we prove that the Cesàro operator is subdecomposable on H1 and on the standard weighted Bergman spaces , [alpha][greater-or-equal, slanted]0.

  19. A simple method for the biochemical purification of Ro/SS-A antigen.

    PubMed

    Wu, D H; Tavoni, A; Garzelli, C; Neri, R; Vitali, C; Bombardieri, S

    1989-07-26

    In the present study, Ro/SS-A antigen has been isolated from human spleen by a two-step procedure. In the first step most of the non-antigenic material was removed by means of ammonium sulphate precipitation and ion exchange chromatography. The final purification was obtained by passing the Ro/SS-A-containing fractions twice through a Mono Q ion exchange fast protein liquid chromatography (FPLC) column. The purified antigen showed identical immunoreactivity with crude material on CIE and was composed of two polypeptides with a molecular weight of approximately 60,000 and 55,000 respectively on SDS-PAGE, both reacting on Western blotting with a panel of anti-Ro/SS-A antisera. This system permits milligrams of highly purified antigen to be obtained from grams of human spleen.

  20. Research and development of Ro-boat: an autonomous river cleaning robot

    NASA Astrophysics Data System (ADS)

    Sinha, Aakash; Bhardwaj, Prashant; Vaibhav, Bipul; Mohommad, Noor

    2013-12-01

    Ro-Boat is an autonomous river cleaning intelligent robot incorporating mechanical design and computer vision algorithm to achieve autonomous river cleaning and provide a sustainable environment. Ro-boat is designed in a modular fashion with design details such as mechanical structural design, hydrodynamic design and vibrational analysis. It is incorporated with a stable mechanical system with air and water propulsion, robotic arms and solar energy source and it is proceed to become autonomous by using computer vision. Both "HSV Color Space" and "SURF" are proposed to use for measurements in Kalman Filter resulting in extremely robust pollutant tracking. The system has been tested with successful results in the Yamuna River in New Delhi. We foresee that a system of Ro-boats working autonomously 24x7 can clean a major river in a city on about six months time, which is unmatched by alternative methods of river cleaning.

  1. Planets and stellar activity: hide and seek in the CoRoT-7 system

    NASA Astrophysics Data System (ADS)

    Haywood, R. D.; Collier Cameron, A.; Queloz, D.; Barros, S. C. C.; Deleuil, M.; Fares, R.; Gillon, M.; Lanza, A. F.; Lovis, C.; Moutou, C.; Pepe, F.; Pollacco, D.; Santerne, A.; Ségransan, D.; Unruh, Y. C.

    2014-09-01

    Since the discovery of the transiting super-Earth CoRoT-7b, several investigations have yielded different results for the number and masses of planets present in the system, mainly owing to the star's high level of activity. We re-observed CoRoT-7 in 2012 January with both HARPS and CoRoT, so that we now have the benefit of simultaneous radial-velocity and photometric data. This allows us to use the off-transit variations in the star's light curve to estimate the radial-velocity variations induced by the suppression of convective blueshift and the flux blocked by starspots. To account for activity-related effects in the radial velocities which do not have a photometric signature, we also include an additional activity term in the radial-velocity model, which we treat as a Gaussian process with the same covariance properties (and hence the same frequency structure) as the light curve. Our model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b and CoRoT-7c. We measure the masses of planets b and c to be 4.73 ± 0.95 and 13.56 ± 1.08 M⊕, respectively. The density of CoRoT-7b is (6.61 ± 1.72)(Rp/1.58 R⊕)-3 g cm-3, which is compatible with a rocky composition. We search for evidence of an additional planet d, identified by previous authors with a period close to 9 d. We are not able to confirm the existence of a planet with this orbital period, which is close to the second harmonic of the stellar rotation at ˜7.9 d. Using Bayesian model selection, we find that a model with two planets plus activity-induced variations is most favoured.

  2. The study of Be stars with the CoRoT satellite

    NASA Astrophysics Data System (ADS)

    Diago, P. D.; Gutierrez-Soto, J.; Fabregat, J.; Suso, J.; COROT Be Team

    2011-11-01

    The CoRoT space mission, launched in December 2006, is a spacecraft devoted to the study of the stellar interiors and the exo-planet search. Concerning the seismology of the Be stars, the presence of pulsations in late-type Be stars is still a matter of controversy. It constitutes an important issue to establish the relationship between non-radial pulsations and the mass-loss mechanism in Be stars. In this field, the CoRoT satellite is providing data with an unprecedent quality and precision that is confirming non-radial pulsations in Be stars. The CoRoT Be Team is an international collaboration composed by members from France, Spain, Brazil and Belgium and is in charge of the exploitation and analysis of the Be stars data. In this work we present the highlighted results of the observed Be stars by CoRoT and the future prospects of the CoRoT Be Team. These results include the detection of the Be star HD 49 330 during an outburst phase and the measurement of the change in the oscillation spectrum during this rare event. These observations gave insight into the nature of the explosion. It will help to solve a question that has been pending for years: are oscillations the cause of the outbursts? Moreover, for the first time, the CoRoT satellite has detected simultaneously the rotational and the pulsational frequencies for the Be star HD 50 209, which constitutes a proof of the presence of pulsations in the Be stars. %J Highlights of Spanish Astrophysics VI, Proceedings of the IX Scientific Meeting of the Spanish Astronomical Society (SEA), held in Madrid, September 13 - 17, 2010, Eds.: M. R. Zapatero Osorio, J. Gorgas, J. Maiz Apellaniz, J. R. Pardo, and A. Gil de Paz., p. 531-531

  3. EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

    SciTech Connect

    Deleuil, M.; Meunier, J. C.; Moutou, C.; Surace, C.; Barbieri, M.; Agneray, F.; Granet, Y.; Guterman, P.; Deeg, H. J.; Almenara, J. M.; Hodgkin, S.

    2009-08-15

    Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic plane around CoRoT pointings, with a total area of 209 deg{sup 2}. This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.

  4. Planetary transit candidates in the CoRoT-SRc01 field

    NASA Astrophysics Data System (ADS)

    Erikson, A.; Santerne, A.; Renner, S.; Barge, P.; Aigrain, S.; Alapini, A.; Almenara, J.-M.; Alonso, R.; Auvergne, M.; Baglin, A.; Benz, W.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Cabrera, J.; Carone, L.; Carpano, S.; Csizmadia, Sz.; Deleuil, M.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Ofir, A.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rabus, M.; Rauer, H.; Régulo, C.; Rouan, D.; Samuel, B.; Schneider, J.; Shporer, A.; Tingley, B.; Udry, S.; Wuchterl, G.

    2012-03-01

    Context. The space mission CoRoT is devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. Aims: We present the list of planetary transit candidates detected in the first short run observed by CoRoT that targeted SRc01, towards the Galactic center in the direction of Aquila, which lasted from April to May 2007. Methods: Among the acquired data, we analyzed those for 1269 sources in the chromatic bands and 5705 in the monochromatic band. Instrumental noise and the stellar variability were treated with several detrending tools, to which several transit-search algorithms were subsequently applied. Results: Fifty-one sources were classified as planetary transit candidates and 26 were followed up with ground-based observations. Until now, no planet has been detected in the CoRoT data from the SRc01 field. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with contributions from Austria, Belgium, Brazil, ESA, Germany, and Spain. The CoRoT data are available to the community from the CoRoT archive: http://idoc-corot.ias.u-psud.frBased in part on observations made with the 1.93-m telescope at Observatoire de Haute Provence (CNRS), France (SOPHIE Program 08A.PNP.MOUT).Based in part on observations made with the ESO-3.60-m telescope at La Silla Observatory (ESO), Chile (HARPS Program ESO - 081.C-0388) and with the ESO-VLT telescope at Paranal Observatory (ESO), Chile (FLAMES Program ESO - 081.C-0413).

  5. A Review on the Hemodialysis Reliable Outflow (HeRO) Graft for Haemodialysis Vascular Access.

    PubMed

    Al Shakarchi, J; Houston, J G; Jones, R G; Inston, N

    2015-07-01

    With improved dialysis survival there are increasing numbers of patients who have exhausted definitive access options due to central venous stenosis and are maintaining dialysis on a central venous catheter. The Hemodialysis Reliable Outflow (HeRO) allows an alternative by providing a definitive access solution. The aim of this study is to systematically review the published outcomes of the HeRO graft and discuss the role in complex haemodialysis patients. Electronic databases were searched for studies assessing the use of the HeRO graft for dialysis in accordance with PRISMA published up to December 31 2014. The primary outcomes for this study were 1-year primary and secondary patency rates. Secondary outcomes were rates of dialysis access associated steal syndrome, HeRO-related bacteraemia rates and rates of interventions. Following strict inclusion/exclusion criteria, eight studies including 409 patients were included in our review. Primary and secondary pooled patency rates in this complex cohort of dialysis patients were found to be 21.9% (9.6-37.2%) and 59.4% (39.4-78%). The rate of dialysis access associated steal syndrome was low at 6.3% (1-14.7%) as was the range of HeRO-related bacteraemia (0.13-0.7 events per 1000 days). This literature review shows that the HeRO graft is an acceptable option for complex dialysis patients who are catheter dependent. Owing to device availability, published data are predominantly North American and further longer-term studies in other populations may be necessary. In this challenging patient group, randomized controlled trials are required to allow comparisons with alternative access options. Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  6. Map Showing Susceptibility to Earthquake-Induced Landsliding, San Juan Metropolitan Area, Puerto Rico

    USGS Publications Warehouse

    Santiago, Marilyn; Larsen, Matthew C.

    2001-01-01

    Analysis of slope angle and rock type using a geographic information system indicates that about 68 percent of the San Juan metropolitan area has low to no susceptibility to earthquake-induced landslides. This is at least partly due to the fact that 45 percent of the San Juan metropolitan area is constructed on slopes of 3 degrees or less, which are too gentle for landslides to occur. The areas with the highest susceptibility to earthquake-induced landslides account for 6 percent of the surface area. Almost one-quarter (24 percent) of the San Juan metropolitan area is moderately susceptible to earthquake-induced landslides. These areas are mainly in the southern portions of the San Juan metropolitan area, where housing development pressures are currently high because of land availability and the esthetics of greenery and hillside views. The combination of new development and moderate earthquake-induced landslide susceptibility indicate that the southern portions of the San Juan metropolitan area are be at greatest risk.

  7. Transiting exoplanets from the CoRoT space mission. XVIII. CoRoT-18b: a massive hot Jupiter on a prograde, nearly aligned orbit

    NASA Astrophysics Data System (ADS)

    Hébrard, G.; Evans, T. M.; Alonso, R.; Fridlund, M.; Ofir, A.; Aigrain, S.; Guillot, T.; Almenara, J. M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cabrera, J.; Carone, L.; Carpano, S.; Cavarroc, C.; Csizmadia, Sz.; Deeg, H. J.; Deleuil, M.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Gandolfi, D.; Gibson, N.; Gillon, M.; Guenther, E.; Hatzes, A.; Havel, M.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Mazeh, T.; Moutou, C.; Ollivier, M.; Parviainen, H.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Wuchterl, G.

    2011-09-01

    We report the detection of CoRoT-18b, a massive hot Jupiter transiting in front of its host star with a period of 1.9000693 ± 0.0000028 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite combined with spectroscopic and photometric ground-based follow-up observations. The planet has a mass Mp = 3.47 ± 0.38 MJup, a radius Rp = 1.31 ± 0.18 RJup, and a density ρp = 2.2 ± 0.8 g cm-3. It orbits a G9V star with a mass M⋆ = 0.95 ± 0.15 M⊙, a radius R⋆ = 1.00 ± 0.13 R⊙, and arotation period Prot = 5.4 ± 0.4 days. The age of the system remains uncertain, with stellar evolution models pointing either to a few tens Ma or several Ga, while gyrochronology and lithium abundance point towards ages of a few hundred Ma. This mismatch potentially points to a problem in our understanding of the evolution of young stars, with possibly significant implications for stellar physics and the interpretation of inferred sizes of exoplanets around young stars. We detected the Rossiter-McLaughlin anomaly in the CoRoT-18 system thanks to the spectroscopic observation of a transit. We measured the obliquity ψ = 20° ± 20° (sky-projected value λ = -10° ± 20°), indicating that the planet orbits in the same way as the star is rotating and that this prograde orbit is nearly aligned with the stellar equator. The CoRoT space mission, launched on 2006 December 27, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain.Table 2 is available in electronic form at http://www.aanda.org

  8. Transiting exoplanets from the CoRoT space mission. V. CoRoT-Exo-4b: stellar and planetary parameters

    NASA Astrophysics Data System (ADS)

    Moutou, C.; Bruntt, H.; Guillot, T.; Shporer, A.; Guenther, E.; Aigrain, S.; Almenara, J. M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barbieri, M.; Barge, P.; Benz, W.; Bordé, P.; Bouchy, F.; Deeg, H. J.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gillon, M.; Gondoin, P.; Hatzes, A.; Hébrard, G.; Jorda, L.; Kabath, P.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Magain, P.; Mayor, M.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rabus, M.; Rauer, H.; Rouan, D.; Schneider, J.; Udry, S.; Wuchterl, G.

    2008-09-01

    Aims: The CoRoT satellite has announced its fourth transiting planet (Aigrain et al. 2008, A&A, 488, L43) with space photometry. We describe and analyse complementary observations of this system performed to establish the planetary nature of the transiting body and to estimate the fundamental parameters of the planet and its parent star. Methods: We have analysed high precision radial-velocity data, ground-based photometry, and high signal-to-noise ratio spectroscopy. Results: The parent star CoRoT-Exo-4 (2MASS 06484671-0040219) is a late F-type star of mass of 1.16 M⊙ and radius of 1.17 R⊙. The planet has a circular orbit with a period of 9.20205 d. The planet radius is 1.19 R_Jup and the mass is 0.72 M_Jup. It is a gas-giant planet with a “normal” internal structure of mainly H and He. CoRoT-Exo-4b has the second longest period of the known transiting planets. It is an important discovery since it occupies an empty area in the mass-period diagram of transiting exoplanets. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain; and on observations made with the SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07B.MOUT), and the HARPS spectrograph at ESO La Silla Observatory (079.C-0127/F). Table 2 and Fig. 5 are only available in electronic form at http://www.aanda.org

  9. Transiting exoplanets from the CoRoT space mission. XX. CoRoT-20b: A very high density, high eccentricity transiting giant planet

    NASA Astrophysics Data System (ADS)

    Deleuil, M.; Bonomo, A. S.; Ferraz-Mello, S.; Erikson, A.; Bouchy, F.; Havel, M.; Aigrain, S.; Almenara, J.-M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Bordé, P.; Bruntt, H.; Cabrera, J.; Carpano, S.; Cavarroc, C.; Csizmadia, Sz.; Damiani, C.; Deeg, H. J.; Dvorak, R.; Fridlund, M.; Hébrard, G.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Jorda, L.; Léger, A.; Lammer, H.; Mazeh, T.; Moutou, C.; Ollivier, M.; Ofir, A.; Parviainen, H.; Queloz, D.; Rauer, H.; Rodríguez, A.; Rouan, D.; Santerne, A.; Schneider, J.; Tal-Or, L.; Tingley, B.; Weingrill, J.; Wuchterl, G.

    2012-02-01

    We report the discovery by the CoRoT space mission of a new giant planet, CoRoT-20b. The planet has a mass of 4.24 ± 0.23 MJup and a radius of 0.84 ± 0.04 RJup. With a mean density of 8.87 ± 1.10 g cm-3, it is among the most compact planets known so far. Evolutionary models for the planet suggest a mass of heavy elements of the order of 800 M⊕ if embedded in a central core, requiring a revision either of the planet formation models or both planet evolution and structure models. We note however that smaller amounts of heavy elements are expected by more realistic models in which they are mixed throughout the envelope. The planet orbits a G-type star with an orbital period of 9.24 days and an eccentricity of 0.56.The star's projected rotational velocity is vsini = 4.5 ± 1.0 km s-1, corresponding to a spin period of 11.5 ± 3.1 days if its axis of rotation is perpendicular to the orbital plane. In the framework of Darwinian theories and neglecting stellar magnetic breaking, we calculate the tidal evolution of the system and show that CoRoT-20b is presently one of the very few Darwin-stable planets that is evolving toward a triple synchronous state with equality of the orbital, planetary and stellar spin periods. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain.

  10. Multiple star systems observed with CoRoT and Kepler

    NASA Astrophysics Data System (ADS)

    Southworth, John

    2015-09-01

    The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

  11. Fetal manifestations of maternal anti‐Ro and La antibodies – more than complete heart block

    PubMed Central

    2015-01-01

    Abstract Complete heart block (CHB) is a potentially fatal condition occurring in approximately 1:10000 fetuses. Whilst it is well recognised that maternal anti‐Ro and La antibodies are associated with fetal CHB, there are multiple other manifestations of fetal exposure to these autoantibodies which are not widely appreciated and rarely diagnosed. The importance of identifying affected fetuses lies in the significantly increased risk of recurrence in future pregnancies, and the potential for treatments which may modify this risk. This paper presents several cases to highlight the varying fetal presentations of maternal anti‐Ro and La antibodies. PMID:28191254

  12. How to separate the low amplitude delta Scuti variation in CoRoT data unambigousely?

    NASA Astrophysics Data System (ADS)

    Benko, Jozsef M.; Paparo, Margit

    2015-08-01

    Rich regular frequency patterns were found in the Fourier spectra of low-amplitude Delta Scuti stars observed by CoRoT satellite. The CoRoT observations are, however, influenced by the disturbing effect of the SAA. The effect is marginal for high amplitude variable stars but it could be dangerous in the case of low amplitude variables, especially if the frequency range of the intrinsic variation overlaps the instrumental frequencies. Systematic tests were carried out both on synthetic and real data. Our aim was to determine a limit amplitude above which we were sure that the frequency pattern belonged to the stars.

  13. Galactic Archaeology with CoRoT and APOGEE: Creating mock observations from a chemodynamical model

    NASA Astrophysics Data System (ADS)

    Anders, F.; Chiappini, C.; Rodrigues, T. S.; Piffl, T.; Mosser, B.; Miglio, A.; Montalbán, J.; Girardi, L.; Minchev, I.; Valentini, M.; Steinmetz, M.

    2016-09-01

    In a companion paper, we have presented the combined asteroseismic-spectroscopic dataset obtained from CoRoT light curves and APOGEE infra-red spectra for 606 solar-like oscillating red giants in two fields of the Galactic disc (CoRoGEE). We have measured chemical abundance patterns, distances, and ages of these field stars which are spread over a large radial range of the Milky Way's disc. Here we show how to simulate this dataset using a chemodynamical Galaxy model. We also demonstrate how the observation procedure influences the accuracy of our estimated ages.

  14. CoRoT archive as a treasury of variable stars

    NASA Astrophysics Data System (ADS)

    Benko, Jozsef M.; Paparo, Margit

    2015-08-01

    The CoRoT satellite supported the scientific community by a huge data base of variable stars. The investigation of RR Lyrae stars (radially pulsating classical variable stars of high amplitude), especially benefit the continuous space data, due to long periodicity. The CoRoT RR Lyrae stars were intensively discussed in numerous papers in the last few years, but the latest runs have not been checked for finding RR Lyrae stars up to now. We found eight new RR Lyrae stars that we investigated for the lately localized characteristics of Blazhko RR Lyrae stars: the period doubling and additional modes. We present the preliminary results here.

  15. Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives.

    PubMed

    Santos-Pardo, Irene; Villuendas, Roger; Salvador-Corres, Iñaki; Martínez-Morillo, Melania; Olivé, Alejandro; Bayes-Genis, Antoni

    2015-04-01

    Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies. Copyright © 2014. Published by Elsevier Ireland Ltd.

  16. Beta2-glycoprotein-I and Protection from Anti-SSA/Ro 60 Associated Cardiac Manifestations of Neonatal Lupus

    PubMed Central

    Reed, Joanne H.; Clancy, Robert M.; Purcell, Anthony W.; Kim, Mimi Y.; Gordon, Tom P.; Buyon, Jill P.

    2011-01-01

    One mechanism to molecularly explain the strong association of maternal anti-Ro60 antibodies with cardiac disease in neonatal lupus (NL) is that these antibodies initiate injury by binding to apoptotic cardiomyocytes in the fetal heart. Previous studies have demonstrated that beta2-glycoprotein I (β2GPI) interacts with Ro60 on the surface of apoptotic Jurkat cells and prevents binding of anti-Ro60 IgG. Accordingly, the current study was initiated to test two complementary hypotheses a) competition between β2GPI and maternal anti-Ro60 antibodies for binding apoptotic induced surface translocated Ro60 occurs on human fetal cardiomyocytes and b) circulating levels of β2GPI influence injury in anti-Ro60 exposed fetuses. Initial flow cytometry experiments conducted on apoptotic human fetal cardiomyocytes demonstrated dose-dependent binding of β2GPI. In competitive inhibition experiments, β2GPI prevented opsonisation of apoptotic cardiomyocytes by maternal anti-Ro60 IgG. ELISA was used to quantify β2GPI in umbilical cord blood from 97 neonates exposed to anti-Ro60 antibodies, 53 with cardiac NL and 44 with no cardiac disease. β2GPI levels were significantly lower in neonates with cardiac NL. Plasmin-mediated cleavage of β2GPI prevented binding to Ro60 and promoted the formation of pathogenic anti-Ro60 IgG-apoptotic cardiomyocyte complexes. In aggregate these data suggest that intact β2GPI in the fetal circulation may be a novel cardioprotective factor in anti-Ro60-exposed pregnancies. PMID:21602492

  17. Transiting exoplanets from the CoRoT space mission. III. The spectroscopic transit of CoRoT-Exo-2b with SOPHIE and HARPS

    NASA Astrophysics Data System (ADS)

    Bouchy, F.; Queloz, D.; Deleuil, M.; Loeillet, B.; Hatzes, A. P.; Aigrain, S.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Benz, W.; Bordé, P.; Deeg, H. J.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Guillot, T.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Magain, P.; Mayor, M.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pepe, F.; Pont, F.; Rauer, H.; Rouan, D.; Schneider, J.; Triaud, A. H. M. J.; Udry, S.; Wuchterl, G.

    2008-05-01

    We report on the spectroscopic transit of the massive hot-Jupiter CoRoT-Exo-2b observed with the high-precision spectrographs SOPHIE and HARPS. By modeling the radial velocity anomaly occurring during the transit due to the Rossiter-McLaughlin (RM) effect, we determine the sky-projected angle between the stellar spin and the planetary orbital axis to be close to zero λ = 7.2 ± 4.5 deg, and we secure the planetary nature of CoRoT-Exo-2b. We discuss the influence of the stellar activity on the RM modeling. Spectral analysis of the parent star from HARPS spectra are presented. Observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07A.MOUT) and HARPS spectrograph at ESO La Silla Observatory (079.C-0127(F)). The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany, and Spain.

  18. Occurrence, quality, and use of ground water in Orcas, San Juan, Lopez, and Shaw Islands, San Juan County, Washington

    USGS Publications Warehouse

    Whiteman, K.J.; Molenaar, Dee; Jacoby, J.M.; Bortleson, G.V.

    1983-01-01

    Ground water, which supplies most of San Juan County 's water needs, occurs in both bedrock and glacial drift. Water in the bedrock occurs in fractures in the otherwise dense, poorly permeable rock. Deposits of sand and gravel in the glacial drift provide the best yields to wells drilled into unconsolidated materials. Specific capacities of bedrock wells are typically low, and those of glacial-drift wells considerably higher. Ground water is high in dissolved solids and hardness; 29 of 56 wells sampled had water classified as very hard. Sixteen percent of the 171 ground-water sites tested for indicator bacteria had positive counts of one or more of these bacteria: total coliform , fecal coliform, fecal streptococcus. Nine percent of the 279 wells sampled for chloride in September 1981, appear to be affected by seawater intrusion. All of these wells are located within a mile of the coast; 60 percent of these wells are on Lopez Island. In 1980 an estimated total of 220 million gallons of ground water was withdrawn for all uses. Ninety percent of all ground-water use is for domestic and public supply purposes. Heavy pumpage on northern and southern Lopez Island correlates with areas having high chloride concentrations. (USGS)

  19. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a) The...

  20. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a) The...

  1. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a) The...

  2. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a) The...

  3. 33 CFR 3.35-25 - Sector San Juan Marine Inspection Zone and Captain of the Port Zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sector San Juan Marine Inspection..., DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AREAS, DISTRICTS, SECTORS, MARINE INSPECTION ZONES, AND CAPTAIN OF THE PORT ZONES Seventh Coast Guard District § 3.35-25 Sector San Juan Marine Inspection...

  4. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  5. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  6. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  7. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  8. 78 FR 28800 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Application for Subzone; Parapiezas Corporation; San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, Puerto Rico; Application for Subzone; Parapiezas Corporation; San Juan, Puerto Rico An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Puerto Rico Trade & Export Company, grantee of FTZ 61, requesting special...

  9. Friday Harbor Marina Expansion Study--San Juan Island, Washington: Final Detailed Project Report and Environmental Assessment.

    DTIC Science & Technology

    1981-04-01

    Juan Marina Inc. Don F. Brown Self Steve F. Brown San Juan Marina Inc. Thoms Chittenden Self Alex D. Crichton Self Alan C,-mings KGMI-Bellingham Lois...Self Susan E. Risser Self Noble W. Starr Self Thomas C. Starr Self Corinne R. Towne Se"I Michael P. Vouri Bellingham Marine Industries June M. Vynne Self

  10. Continuing Investigations of the Relationship between Fin Whales, Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge

    DTIC Science & Technology

    2012-09-30

    detect fin whale calls along the tracks, and analyzed the results for call characteristics, calling patterns, swimming patterns, net seasonal migration ... Whales , Zooplankton Concentrations and Hydrothermal Venting on the Juan de Fuca Ridge William S. D. Wilcock School of Oceanography...We are investigating the potential correlation between fin whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de

  11. Continuing Investigations of the Relationship Between Fin Whales, Zooplankton Concentrations and Hydrothermal Venting on the Juan De Fuca Ridge

    DTIC Science & Technology

    2013-09-30

    Fin Whales , Zooplankton Concentrations and Hydrothermal Venting on the Juan De Fuca Ridge William S. D. Wilcock School of Oceanography...are investigating the potential correlation between fin whale tracks, enhanced zooplankton concentrations and hydrothermal vents above the Juan de...Fuca Ridge. Our goal is to understand the influences of globally distributed hydrothermal plumes on the trophic ecology of the deep ocean

  12. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  13. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  14. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and...

  15. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use,...

  16. 33 CFR 334.1180 - Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. 334.1180 Section 334.1180 Navigation and Navigable... REGULATIONS § 334.1180 Strait of Juan de Fuca, Wash.; air-to-surface weapon range, restricted area. (a)...

  17. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  18. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  19. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  20. 33 CFR 167.1303 - In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Juan de Fuca: Precautionary area âJF.â 167.1303 Section 167.1303 Navigation and Navigable Waters....1303 In the approaches to the Strait of Juan de Fuca: Precautionary area “JF.” In the approaches to the Strait of Juan de Fuca, precautionary area “JF” is established and is bounded by a line connecting...

  1. The Juan non-LTR retrotransposon in mosquitoes: genomic impact, vertical transmission and indications of recent and widespread activity

    PubMed Central

    Biedler, James K; Tu, Zhijian

    2007-01-01

    Background In contrast to DNA-mediated transposable elements (TEs), retrotransposons, particularly non-long terminal repeat retrotransposons (non-LTRs), are generally considered to have a much lower propensity towards horizontal transfer. Detailed studies on site-specific non-LTR families have demonstrated strict vertical transmission. More studies are needed with non-site-specific non-LTR families to determine whether strict vertical transmission is a phenomenon related to site specificity or a more general characteristic of all non-LTRs. Juan is a Jockey clade non-LTR retrotransposon first discovered in mosquitoes that is widely distributed in the mosquito family Culicidae. Being a non-site specific non-LTR, Juan offers an opportunity to further investigate the hypothesis that non-LTRs are genomic elements that are primarily vertically transmitted. Results Systematic analysis of the ~1.3 Gbp Aedes aegypti (Ae. aegypti) genome sequence suggests that Juan-A is the only Juan-type non-LTR in Aedes aegypti. Juan-A is highly reiterated and comprises approximately 3% of the genome. Using minimum cutoffs of 90% length and 70% nucleotide (nt) identity, 663 copies were found by BLAST using the published Juan-A sequence as the query. All 663 copies are at least 95% identical to Juan-A, while 378 of these copies are 99% identical to Juan-A, indicating that the Juan-A family has been transposing recently in evolutionary history. Using the 0.34 Kb 5' UTR as the query, over 2000 copies were identified that may contain internal promoters, leading to questions on the genomic impact of Juan-A. Juan sequences were obtained by PCR, library screening, and database searches for 18 mosquito species of six genera including Aedes, Ochlerotatus, Psorophora, Culex, Deinocerites, and Wyeomyia. Comparison of host and Juan phylogenies shows overall congruence with few exceptions. Conclusion Juan-A is a major genomic component in Ae. aegypti and it has been retrotransposing recently in

  2. Transiting exoplanets from the CoRoT space mission. II. CoRoT-Exo-2b: a transiting planet around an active G star

    NASA Astrophysics Data System (ADS)

    Alonso, R.; Auvergne, M.; Baglin, A.; Ollivier, M.; Moutou, C.; Rouan, D.; Deeg, H. J.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Benz, W.; Bordé, P.; Bouchy, F.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gillon, M.; Gondoin, P.; Guillot, T.; Hatzes, A.; Hébrard, G.; Kabath, P.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Magain, P.; Mayor, M.; Mazeh, T.; Pätzold, M.; Pepe, F.; Pont, F.; Queloz, D.; Rauer, H.; Shporer, A.; Schneider, J.; Stecklum, B.; Udry, S.; Wuchterl, G.

    2008-05-01

    Context: The CoRoT mission, a pioneer in exoplanet searches from space, has completed its first 150 days of continuous observations of ~12 000 stars in the galactic plane. An analysis of the raw data identifies the most promising candidates and triggers the ground-based follow-up. Aims: We report on the discovery of the transiting planet CoRoT-Exo-2b, with a period of 1.743 days, and characterize its main parameters. Methods: We filter the CoRoT raw light curve of cosmic impacts, orbital residuals, and low frequency signals from the star. The folded light curve of 78 transits is fitted to a model to obtain the main parameters. Radial velocity data obtained with the SOPHIE, CORALIE and HARPS spectrographs are combined to characterize the system. The 2.5 min binned phase-folded light curve is affected by the effect of sucessive occultations of stellar active regions by the planet, and the dispersion in the out of transit part reaches a level of 1.09×10-4 in flux units. Results: We derive a radius for the planet of 1.465 ± 0.029 R_Jup and a mass of 3.31 ± 0.16 M_Jup, corresponding to a density of 1.31 ± 0.04 g/cm^3. The large radius of CoRoT-Exo-2b cannot be explained by current models of evolution of irradiated planets. Based on observations obtained with CoRoT, a space project operated by the French Space Agency, CNES, with participation of the Science Programme of ESA, ESTEC/RSSD, Austria, Belgium, Brazil, Germany and Spain; and on observations made with SOPHIE spectrograph at Observatoire de Haute Provence, France (PNP.07 A.MOUT), CORALIE, and HARPS spectrograph at ESO La Silla Observatroy (079.C-0127/F)). Table 2 is only available in electronic form at http://www.aanda.org

  3. Geology of the Cedar Mesa-Boundary Butte area, San Juan County, Utah

    USGS Publications Warehouse

    O'Sullivan, Robert B.

    1965-01-01

    The Cedar Mesa-Boundary Butte area lies within the Colorado Plateau and includes about 650 square miles in southern San Juan County, Utah. Altitudes ranges from 3,890 feet on the westward-flowing San Juan River, the major and only perennial stream, to more than 6,400 feet on Cedar Mesa in the northwest. Bare rocks, high mesas, sheer cliffs, and deep canyons characterize the area. Comb Ridge, a prominent hogback of eastward-dipping rocks, trends north through the middle part of the area and is the most conspicuous topographic feature. The only permanent settlements are Bluff in the east and Mexican Hat in the west, both on the San Juan River.

  4. A jewel in the desert: BHP Billiton's San Juan underground mine

    SciTech Connect

    Buchsbaum, L.

    2007-12-15

    The Navajo Nation is America's largest native American tribe by population and acreage, and is blessed with large tracks of good coal deposits. BHP Billiton's New Mexico Coal Co. is the largest in the Navajo regeneration area. The holdings comprise the San Juan underground mine, the La Plata surface mine, now in reclamation, and the expanding Navajo surface mine. The article recounts the recent history of the mines. It stresses the emphasis on sensitivity to and helping to sustain tribal culture, and also on safety. San Juan's longwall system is unique to the nation. It started up as an automated system from the outset. Problems caused by hydrogen sulfide are being tackled. San Juan has a bleederless ventilation system to minimise the risk of spontaneous combustion of methane and the atmospheric conditions in the mine are heavily monitored, especially within the gob areas. 3 photos.

  5. Segmented Subduction Across the Juan De Fuca Plate: Challenges in Imaging with an Amphibious Array

    NASA Astrophysics Data System (ADS)

    Hawley, W. B.; Allen, R. M.

    2014-12-01

    The Cascadia Initiative (CI) is an amphibious array spanning the Juan de Fuca plate from formation at the ridge to the destruction of the slab in the mantle beneath western North America. This ambitions project has occupied over 300 onshore and offshore sites, providing an unprecedented opportunity to understand the dynamics of oceanic plates. The CI project is now in its fourth and final year of deployment. Here we present constraints on the structure of the Juan de Fuca plate and its interaction with western North America. We identify segmentation along the Cascadia subduction zone that can be traced back onto the Juan de Fuca plate prior to subduction. These results give insight into the life cycle of oceanic plates, from their creation at a mid-ocean ridge to their subduction and subsequent recycling into the mantle.

  6. The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

    PubMed Central

    Zhang, Ali; Zhou, Nanjiang; Huang, Jianguo; Liu, Qian; Fukuda, Koji; Ma, Ding; Lu, Zhaohui; Bai, Cunxue; Watabe, Kounosuke; Mo, Yin-Yuan

    2013-01-01

    It is well known that upon stress, the level of the tumor suppressor p53 is remarkably elevated. However, despite extensive studies, the underlying mechanism involving important inter-players for stress-induced p53 regulation is still not fully understood. We present evidence that the human lincRNA-RoR (RoR) is a strong negative regulator of p53. Unlike MDM2 that causes p53 degradation through the ubiquitin-proteasome pathway, RoR suppresses p53 translation through direct interaction with the heterogeneous nuclear ribonucleoprotein I (hnRNP I). Importantly, a 28-base RoR sequence carrying hnRNP I binding motifs is essential and sufficient for p53 repression. We further show that RoR inhibits p53-mediated cell cycle arrest and apoptosis. Finally, we demonstrate a RoR-p53 autoregulatory feedback loop where p53 transcriptionally induces RoR expression. Together, these results suggest that the RoR-hnRNP I-p53 axis may constitute an additional surveillance network for the cell to better respond to various stresses. PMID:23208419

  7. Ro-vibrational Stark effect on H2 and D2 molecules adsorbed in NaA zeolite

    NASA Astrophysics Data System (ADS)

    Bras, N.

    1999-03-01

    In order to explain the induced infrared bands of H2 and D2 adsorbed in NaA zeolites the Stark effect on the ro-vibrational levels of these molecules is considered for electric fields created by various charge distributions. The shift and intensity of the induced ro-vibration transitions are calculated.

  8. Establishment of rock bream Oplegnathus fasciatus embryo (RoBE-4) cells with cytolytic infection of red seabream iridovirus (RSIV).

    PubMed

    Oh, So-Young; Nishizawa, Toyohiko

    2016-12-01

    Red seabream iridovirus (RSIV) is a member of genus Megalocytivirus in the family Iridoviridae. RSIV infection causes significant economic losses of marine-fishes in East Asian countries. Grunt fin (GF) cell line has been commonly used for culturing RSIV. However, it is not suitable for definite evaluation of infectivity titer of RSIV because cells infected with RSIV are not completely cytolysed. Thus, we established a new cell line, RoBE-4, from rock bream (Oplegnathus fasciatus) eyed-egg embryos in this study. Morphologically, RoBE-4 cells were fibroblastic-like. They have been stably grown over two-years with 60 passages using Leibovitz's L-15 medium containing 10% (v/v) fetal bovine serum. RoBE-4 cells infected with RSIV exhibited cytopathic effects (CPE) with cell rounding. They were cytolysed completely after ≥2 weeks of culture. Numerous RSIV particles with icosahedral morphology of approximately 122nm in diameter were observed in cytoplasmic area of infected RoBE-4 cells. The RSIV-suceptibility and amount of extracellular RSIV released by RoBE-4 cells were 100-fold higher than those by GF cells. RSIV cultured with RoBE-4 cells was highly virulent to rock bream in infection experiments. Therefore, using RoBE-4 cells instead of GF cells will enable accurate and sensitive measurement of RSIV infectivity. In addition, RoBE-4 cells might be used to produce RSIV vaccine in the future with significant reduction in cost.

  9. Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR

    PubMed Central

    Morin, Cory W.; Monaghan, Andrew J.; Hayden, Mary H.; Barrera, Roberto; Ernst, Kacey

    2015-01-01

    Meteorological factors influence dengue virus ecology by modulating vector mosquito population dynamics, viral replication, and transmission. Dynamic modeling techniques can be used to examine how interactions among meteorological variables, vectors and the dengue virus influence transmission. We developed a dengue fever simulation model by coupling a dynamic simulation model for Aedes aegypti, the primary mosquito vector for dengue, with a basic epidemiological Susceptible-Exposed-Infectious-Recovered (SEIR) model. Employing a Monte Carlo approach, we simulated dengue transmission during the period of 2010–2013 in San Juan, PR, where dengue fever is endemic. The results of 9600 simulations using varied model parameters were evaluated by statistical comparison (r2) with surveillance data of dengue cases reported to the Centers for Disease Control and Prevention. To identify the most influential parameters associated with dengue virus transmission for each period the top 1% of best-fit model simulations were retained and compared. Using the top simulations, dengue cases were simulated well for 2010 (r2 = 0.90, p = 0.03), 2011 (r2 = 0.83, p = 0.05), and 2012 (r2 = 0.94, p = 0.01); however, simulations were weaker for 2013 (r2 = 0.25, p = 0.25) and the entire four-year period (r2 = 0.44, p = 0.002). Analysis of parameter values from retained simulations revealed that rain dependent container habitats were more prevalent in best-fitting simulations during the wetter 2010 and 2011 years, while human managed (i.e. manually filled) container habitats were more prevalent in best-fitting simulations during the drier 2012 and 2013 years. The simulations further indicate that rainfall strongly modulates the timing of dengue (e.g., epidemics occurred earlier during rainy years) while temperature modulates the annual number of dengue fever cases. Our results suggest that meteorological factors have a time-variable influence on dengue transmission relative to other important

  10. The Yale/San Juan Southern Proper Motion Program

    NASA Astrophysics Data System (ADS)

    van Altena, W. F.; Girard, T. M.; Platais, I.; Kozhurina-Platais, V.; Ostheimer, J.; Lopez, C. E.; Mendez, R. A.

    1999-09-01

    The SPM is based on photographic plates taken at our observatory at El Leoncito, Argentina and will yield absolute proper motions and positions to magnitude B 19 for approximately 1 million stars south of declination -20 degrees. The SPM is a joint program between the Yale Southern Observatory and the Universidad Nacional de San Juan, Argentina. The SPM Catalog 2.0 provides positions, absolute proper motions, and photographic BV photometry for over 320,000 stars and galaxies. All objects contained in the SPM 1.0 Catalog (the South Galactic Pole region) are also included in this version. Note that SPM 1.0 has been replaced by SPM 1.1 which has slightly different astrometry (mostly proper motions) due to refinement of the magnitude equation correction in the SPM 2.0 Catalog. The Catalog covers an area of 3700 square degrees in an irregularly bounded band between declinations of -43 and -22 degrees, but excluding fields in the plane of the Milky Way. Stars cover the magnitude range 5 < V < 18.5. The standard errors for the best measured stars are as follows: 20 mas for positions in each coordinate; 2 mas/yr for absolute proper motions and 0.05 mag in B and V bandpasses. In addition to the Catalog, a list of CCD calibrating sequences in BV is provided. It contains 7783 stars. The new feature of the Catalog is an extensive list of cross-identifications with external special catalogs which include all major astrometric catalogs and a large number of astrophysically interesting objects. The Catalog is available on the WWW at http://www.astro.yale.edu/astrom/. Our web-site contains several useful plots showing the sky coverage, error distribution, a quick comparison with the Hipparcos proper motions, etc.

  11. Diagnosing a male hysteric: Don Juan-type.

    PubMed

    Lubbe, Trevor

    2003-08-01

    The aim of this paper is to provide a clinical account of a male hysteric, Don Juan-type, taken from the early stages of treatment. The patient presented with a relationship problem but there soon emerged a form of compulsive sexuality or hypersexuality in his love relations that became a central feature of the clinical picture. This hypersexuality expressed itself in a compulsive need to stage, or to stage-manage, interpersonal scenaria of a sexual or sexualised nature. These scenaria, which were repeated in different variations and with different personnel, are seen by the author as a dramatisation of the primal scene with the patient taking up the position of the oedipal father. Explanations for the disappearance of male hysteria are given, including a new theory which claims that an imbalance in psychoanalytic theory itself led to the feminisation of hysteria. This critique allows certain forms of hypersexuality in men to be promoted as a form of hysteria, the most common example being Don Juanism-a form of compulsive sexuality that encompasses normative, conversion and character features. The paper also examines the male hysteric's developmental agenda. What the patient's compulsive sexual tableaux exposed was that he had never faced a separation that was not a triangular experience. This meant that his separations were experienced as two developmental agonies telescoped into one-separation (pre-oedipal) and exclusion (early oedipal). This combination, the author suggests, is so frightening in a particular group of men as to explain the choice of hysteria as opposed to some other choice of neurosis.

  12. Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR.

    PubMed

    Morin, Cory W; Monaghan, Andrew J; Hayden, Mary H; Barrera, Roberto; Ernst, Kacey

    2015-08-01

    Meteorological factors influence dengue virus ecology by modulating vector mosquito population dynamics, viral replication, and transmission. Dynamic modeling techniques can be used to examine how interactions among meteorological variables, vectors and the dengue virus influence transmission. We developed a dengue fever simulation model by coupling a dynamic simulation model for Aedes aegypti, the primary mosquito vector for dengue, with a basic epidemiological Susceptible-Exposed-Infectious-Recovered (SEIR) model. Employing a Monte Carlo approach, we simulated dengue transmission during the period of 2010-2013 in San Juan, PR, where dengue fever is endemic. The results of 9600 simulations using varied model parameters were evaluated by statistical comparison (r2) with surveillance data of dengue cases reported to the Centers for Disease Control and Prevention. To identify the most influential parameters associated with dengue virus transmission for each period the top 1% of best-fit model simulations were retained and compared. Using the top simulations, dengue cases were simulated well for 2010 (r2 = 0.90, p = 0.03), 2011 (r2 = 0.83, p = 0.05), and 2012 (r2 = 0.94, p = 0.01); however, simulations were weaker for 2013 (r2 = 0.25, p = 0.25) and the entire four-year period (r2 = 0.44, p = 0.002). Analysis of parameter values from retained simulations revealed that rain dependent container habitats were more prevalent in best-fitting simulations during the wetter 2010 and 2011 years, while human managed (i.e. manually filled) container habitats were more prevalent in best-fitting simulations during the drier 2012 and 2013 years. The simulations further indicate that rainfall strongly modulates the timing of dengue (e.g., epidemics occurred earlier during rainy years) while temperature modulates the annual number of dengue fever cases. Our results suggest that meteorological factors have a time-variable influence on dengue transmission relative to other important

  13. Prevalence of the Metabolic Syndrome in San Juan, Puerto Rico

    PubMed Central

    Pérez, Cynthia M.; Guzmán, Manuel; Ortiz, Ana P.; Estrella, Mayra; Valle, Yari; Pérez, Naydi; Haddock, Lillian; Suárez, Erick

    2009-01-01

    Objective The metabolic syndrome is associated with a high risk of diabetes and cardiovascular disease, and Hispanics in the United States have higher rates than do other ethnic groups. We assessed the prevalence of the metabolic syndrome and its individual components in Puerto Rican adults. Methods We conducted a cross-sectional study that used a probability cluster design to select a sample of households of the San Juan metropolitan area from 2005 through 2007. A total of 859 persons aged 21–79 years completed a face-to-face interview, blood pressure and waist circumference measurements, and blood sampling. Our primary outcome measure was metabolic syndrome as defined by the updated NCEP-ATP criteria. Results Prevalence of the metabolic syndrome was 43.3%; 45.3% for men and 42.2% for women (P>.05). Prevalence significantly rose with age, from 12.8% among participants aged 21–29 years to 58.2% for participants aged 70–79 years (P<.001). Corresponding increases in the prevalence of the metabolic syndrome in both men and women were also observed; the prevalence peaked in men aged 50–59 years (62.6%) and in women aged 70–79 years (65.2%). Elevated glucose (49.8%) and abdominal obesity (49.0%) were the most common components of the metabolic syndrome, followed by elevated blood pressure (46.1%), reduced high-density lipoprotein cholesterol (46.0%), and elevated triglycerides (31.3%). Substantial variations were found between men and women in the prevalence of individual components. Conclusions Puerto Ricans have a high prevalence of the metabolic syndrome. This health disparity has implications for diabetes and cardiovascular prevention programs. PMID:19157247

  14. Laramide tectonic evolution of San Juan sag, Colorado: Implications of Animas and Blanco basin formations

    SciTech Connect

    Brister, B.S. )

    1989-09-01

    The lower member of the Animas Formation (McDermott Member) is a volcaniclastic sequence derived from a north-northwest source (San Juan-La Plata area). It consists of purple andesitic debris flows, green fan-delta sandstones and mud rocks, and dark gray conglomerates with clast compositions indicating that the Precambrian core of the source uplift was exposed. The upper member is a sand-dominated alluvial plain sequence deposited by southwest-flowing braided streams. It includes green-gray-brown carbonaceous mudstones and pebbly sandstones containing clasts of mudstone, andesite, and detritus from Precambrian and Mesozoic sources in the Brazos-San Luis uplift to the east and northeast. by the end of Animas deposition, the San Juan sag (then a northeastern extension of the San Juan basin) was a broad, southwest-plunging synclinal downwarp bounded by hogback monoclines to the north and east. An erosional period followed Animas deposition; the greatest thickness of Animas was preserved along the axis of this synclinal feature. Bright-red sandy mudstones and yellow-gray pebbly sandstones and cobble conglomerates comprise the proximal alluvial-fan deposits of the Blanco Basin Formation. They unconformably overlie Precambrian through Paleocene rocks and clast compositions reflect these sources. Renewed uplift and segmentation of the Brazos-San Luis uplift resulted in the shedding of detritus southwestward into the San Juan sag and eastward into a narrow, asymmetrical, north-trending wrench basin within the uplift. Following Blanco Basin deposition, the last Laramide event is represented by the separation of the San Juan sag from the San Juan basin by uplift of the Archuleta anticlinorium.

  15. The Problem of Longitude in the 18th Century: Jorge Juan, Antonio de Ulloa and the Expedition of the Paris Academy of Sciences to the Kingdom of Peru

    NASA Astrophysics Data System (ADS)

    Gutiérrez, Manuel Pérez

    2015-05-01

    Jorge Juan and Antonio de Ulloa, naval officers of the Spanish Navy in the Midshipmen's Royal Academy were appointed to take part in one of the most important scientific expeditions of the 18th century. The question of the shape of the Earth, of vital importance for navigation, was solved by the Paris Academy of Sciences by request of Louis XV of France in 1735. The aim was to determine the form of the ellipsoid that Newton had described in the 17th century for any spherical and homogeneous body in rotation about an axis. Two expeditions were prepared for the geodetic measures of meridian arc both in high latitudes (Lapland, Finland) and in the equatorial zone (the Kingdom of Peru); Pierre Louis Maupertuis took charge of the northern expedition whereas the second one was charged to La Condamine, along with Jorge Juan and Antonio de Ulloa. The results obtained by the Spaniards were gathered in a publication: Observaciones astronómicas y físicas hechas en los Reinos del Perú. In it, they dedicate a chapter to the determination of astronomic longitude with the only technology that was providing certain precision at the moment: the simultaneous observation of the same astronomic phenomenon in two different places. Specifically, they explain in detail in Book III: Las Observaciones de la Inmersiones y Emersiones de los satélites de Júpiter, como asimismo de los eclipses de Luna; de las cuales de deduce la Longitud de los Lugares, incluyendo las correcciones a efectuar por la variación de la declinación diaria del Sol.

  16. [The medical world of Juan Gil de Zamora's Historia Naturalis (ca. 1275-1296)].

    PubMed

    García Ballester, L; Domínguez, A

    1994-01-01

    The article describes the authors and works which were quoted by the Franciscan Juan Gil de Zamora in his Historia naturalis, a scientific encyclopaedia written between c. 1275 and before 1296, probably in the Franciscan monastery of Zamora (Kingdom of Castille). Juan Gil made wide use of the Avicenna's Canon, Gilbertus de Aquila (Anglicus)'s Compendium medicine, and Salernitan medical literature. His work contributed to the diffusion of these medical authors and works throughout the Christian intellectual milieu of late medieval Castille. This diffusion was not without problems.

  17. RoMPS concept review automatic control of space robot, volume 2

    NASA Technical Reports Server (NTRS)

    Dobbs, M. E.

    1991-01-01

    Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form and include: (1) system concept; (2) Hitchhiker Interface Requirements; (3) robot axis control concepts; (4) Autonomous Experiment Management System; (5) Zymate Robot Controller; (6) Southwest SC-4 Computer; (7) oven control housekeeping data; and (8) power distribution.

  18. Draft Genome Sequence of the Xylella fastidiosa CoDiRO Strain

    PubMed Central

    Chiumenti, Michela; Saponari, Maria; Donvito, Giacinto; Italiano, Alessandro; Loconsole, Giuliana; Boscia, Donato; Cariddi, Corrado; Martelli, Giovanni Paolo; Saldarelli, Pasquale

    2015-01-01

    We determined the draft genome sequence of the Xylella fastidiosa CoDiRO strain, which has been isolated from olive plants in southern Italy (Apulia). It is associated with olive quick decline syndrome (OQDS) and characterized by extensive scorching and desiccation of leaves and twigs. PMID:25676759

  19. Erratum dans le numéro de mai-juin 1988

    NASA Astrophysics Data System (ADS)

    Erratum dans le numéro de mai-juin 1988: Dans l'article sur les étoiles à baryum: p. 74, 2e colonne (après la première formule), il faut lire «A est la masse atomique» au lieu de «nombre atomique»

  20. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension

    PubMed Central

    Guerreso, Kelsey; Conner, Edward Alexander

    2016-01-01

    Introduction There are many different causes of pulmonary hypertension and the pathogenesis of the disease is still being elucidated. Although they are not the most common, autoimmunity and inflammation have been identified as possible causes. No one autoantibody has been identified as the definite cause of pulmonary hypertension. We present a rare association of anti-SSA/Ro antibodies and isolated pulmonary hypertension. Case presentation A 53 year old African American female presented with abdominal pain, nausea, weight loss, dyspnea and fatigue. Upon further exam she was found to have high titers of antinuclear antibodies and anti-SSA/Ro antibodies. This antibody profile would typically be suggestive of Sjögren's Syndrome, which is characterized by dry eyes and poor salivary gland function. However, since this patient did not have any symptoms consistent with the disease a diagnosis of Sjögren's Syndrome could not be made. A combination of laboratory, imaging and diagnostic studies were done that revealed a final diagnosis of pulmonary hypertension. Conclusion It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension. PMID:27222785

  1. CoRoT-2a Magnetic Activity: Hints for Possible Star-Planet Interaction

    NASA Astrophysics Data System (ADS)

    Pagano, Isabella; Lanza, Antonino F.; Leto, Giuseppe; Messina, Sergio; Barge, Pierre; Baglin, Annie

    2009-09-01

    CoRoT-2a is a young (≈0.5 Gyr) G7V star accompanied by a transiting hot-Jupiter, discovered by the CoRoT satellite (Alonso et al. Astron Astrophys 482:L21, 2008; Bouchy et al. Astron Astrophys 482:L25, 2008). An analysis of its photospheric activity, based on spot modelling techniques previously developed by our group for the analysis of the Sun as a star, shows that the active regions on CoRoT-2a arised within two active longitudes separated by about 180° and rotating with periods of 4.5221 and 4.5543 days, respectively, at epoch of CoRoT observations (112 continous days centered at ≈2007.6). We show that the total spotted area oscillates with a period of about 28.9 days, a value close to 10 times the synodic period of the planet with respect to the active longitude pattern rotating in 4.5221 days. Moreover, the variance of the stellar flux is modulated in phase with the planet orbital period. This suggests a possible star-planet magnetic interaction, a phenomenon already seen in other extrasolar planetary systems hosting hot-Jupiters.

  2. Jean Vigo's "Zéro De Conduite" and the Spaces of Revolt

    ERIC Educational Resources Information Center

    Vanobbergen, Bruno; Grosvenor, Ian; Simon, Frank

    2014-01-01

    In this article we will contribute to the contemporary theoretical debate about film by considering, from a history-of-education perspective, the film "Zéro de conduite" by Jean Vigo (1905--1934). This film is classified under the umbrella of "poetic realism": a product of "cinéma de gauche" and an avant-gardist,…

  3. Comparative in vitro activity of Ro 09-1428, a novel cephalosporin with a catechol moiety.

    PubMed

    Qadri, S M; Ayub, A; Ueno, Y; Saldin, H

    1992-01-01

    The in vitro activity of Ro 09-1428, a new parenteral cephalosporin, was compared with that of other beta-lactams and aminoglycosides in 1230 clinical isolates from 1028 consecutive patients. Using an agar dilution method, the drugs were tested against 625 isolates of Enterobacteriaceae, 68 Pseudomonas aeruginosa, 36 Xanthomonas maltophilia, 20 Aeromonas hydrophila, 54 Acinetobacter, 373 staphylococci, and 54 strains of enterococci. More than 98% of Enterobacteriaceae were susceptible to Ro 09-1428, with a minimal inhibitory concentration of less than 0.03 to 4.0 micrograms/ml. Ro 09-1428 also inhibited 99% and 72% of the clinical isolates of P aeruginosa and X maltophilia, respectively. All isolates of methicillin-susceptible Staphylococcus aureus (MSSA) were susceptible to this cephalosporin. However, only 46% of the 54 strains of enterococci exhibited in vitro susceptibility. Ro 09-1428 was found to be superior or comparable to most penicillins, cephalosporins, and aminoglycosides against both gram-negative bacteria and MSSA.

  4. Uncovering the planets and stellar activity of CoRoT-7 using only radial velocities

    NASA Astrophysics Data System (ADS)

    Faria, J. P.; Haywood, R. D.; Brewer, B. J.; Figueira, P.; Oshagh, M.; Santerne, A.; Santos, N. C.

    2016-04-01

    Stellar activity can induce signals in the radial velocities of stars, complicating the detection of orbiting low-mass planets. We present a method to determine the number of planetary signals present in radial-velocity datasets of active stars, using only radial-velocity observations. Instead of considering separate fits with different number of planets, we use a birth-death Markov chain Monte Carlo algorithm to infer the posterior distribution for the number of planets in a single run. In a natural way, the marginal distributions for the orbital parameters of all planets are also inferred. This method is applied to HARPS data of CoRoT-7. We confidently recover the orbits of both CoRoT-7b and CoRoT-7c although the data show evidence for the presence of additional signals. All data and software presented in this article are available online at http://https://github.com/j-faria/exoBD-CoRoT7

  5. 77 FR 33127 - Airworthiness Directives; HPH s. r.o. Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; HPH s. r.o. Sailplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice... continuing airworthiness information (MCAI) originated by an aviation authority of another country to...

  6. Highly Oxidized RO2 Radicals and Consecutive Products from the Ozonolysis of Three Sesquiterpenes.

    PubMed

    Richters, Stefanie; Herrmann, Hartmut; Berndt, Torsten

    2016-03-01

    The formation of highly oxidized multifunctional organic compounds (HOMs) from the ozonolysis of three sesquiterpenes, α-cedrene, β-caryophyllene, and α-humulene, was investigated for the first time. Sesquiterpenes contribute 2.4% to the global carbon emission of biogenic volatile organic compounds (BVOCs) and can be responsible for up to 70% of the regional BVOC emissions. HOMs were detected with chemical ionization-atmospheric pressure interface-time-of-flight mass spectrometry and nitrate and acetate ionization. Acetate ions were more sensitive toward highly oxidized RO2 radicals containing a single hydroperoxide moiety. Under the chosen reaction conditions, product formation was dominated by highly oxidized RO2 radicals which react with NO, NO2, HO2, and other RO2 radicals under atmospheric conditions. The ozonolysis of sesquiterpenes resulted in molar HOM yields of 0.6% for α-cedrene (acetate), 1.8% for β-caryophyllene (acetate), and 1.4% for α-humulene (nitrate) afflicted with an uncertainty factor of 2. Molar yields of highly oxidized RO2 radicals were identical with HOM yields measuring the corresponding closed-shell products. HOM formation from ozonolysis of α-cedrene was explained by an autoxidation mechanism initiated by ozone attack at the double bond similar to that found in the ozonolysis of cyclohexene and limonene.

  7. RO filtration of biologically treated textile and dyeing effluents using ozonation as a pre-treatment.

    PubMed

    Wang, H Y; Guan, Y T; Mizuno, T; Tsuno, H

    2010-01-01

    Bench-scale experiments were conducted to investigate the application of ozonation pre-treatment for biologically treated textile and dyeing wastewater to improve performance of the RO process. Based on ozonation experiments, four specific ozone consumptions (SOC), 0, 0.3, 0.6, 4.0 mg O₃/mg DOC₀ were chosen for study of the effects of ozonation on the reverse osmosis (RO) process. Membrane flux was recorded. Also, the permeate water quality parameters such as TOC, conductivity were analyzed. In addition, fouled membrane cleaning was studied. The study further examined the nature and mechanisms of membrane fouling using scanning electron microscopy (SEM) and the energy dispersive X-ray spectrometer (EDS). The effect of ozonation on RO filtration was found to depend on SOC. The study revealed that significant improvement can be achieved in the efficiency of RO filtration by employing ozonation with 0.6 mg O₃/mg DOC₀ SOC. Although the product water purity slightly decreased, the ozonation pre-treatment showed advantages at 0.6 mg O₃/mg DOC₀ SOC for the following: (i) mitigation of flux decline due to membrane fouling; (ii) improvement in foulants cleanability. In addition, hypotheses were put forward to explain the reasons from the aspect of organic matter characteristics changed by ozonation, such as changing on functional groups and molecular weight of organic matter.

  8. HD 12098 a new far-northern roAp star

    NASA Astrophysics Data System (ADS)

    Girish, V.; Joshi, S.; Seetha, S.; Ashoka, B. N.; Martinez, P.; Chaubey, U. S.; Gupta, S. K.; Kurtz, D. W.; Sagar, R.

    2001-09-01

    The rapidly oscillating Ap (roAp) stars are cool, magnetic, chemically peculiar stars which pulsate in non-radial p-modes in the period range 4-16 min and have Johnson B amplitudes less than 8 mmag. "The NainiTal-Cape survey" to search for and study new roAp stars in the northern hemisphere was initiated in 1998 in collaboration between ISAC & UPSO from India and SAAO & UCT from South Africa. HD12098 is the first roAp star discovered in this survey and also the first far northern hemisphere roAp star. During the initial observations the star showed modulation in the pulsation amplitude indicating the multi-periodicity of pulsations. The multi-periodicity may be either due to the excitation of different modes or due to the rotation of the star. In order to resolve these frequencies HD12098 was observed extensively in October 2000. The preliminary results of these observations are presented here.

  9. Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

    PubMed Central

    McCauliffe, D P; Lux, F A; Lieu, T S; Sanz, I; Hanke, J; Newkirk, M M; Bachinski, L L; Itoh, Y; Siciliano, M J; Reichlin, M

    1990-01-01

    Ro/SS-A antibodies are found in a number of human autoimmune disorders including Sjogren's syndrome and several systemic lupus erythematosus-related disorders. These heterogeneous autoantibodies are known to recognize several distinct cellular antigens. With synthetic oligonucleotides corresponding to amino acid sequence information we have isolated a full-length cDNA clone which encodes a human Ro ribonucleoprotein autoantigen. The 1,890-base pair clone contains an open reading frame that encodes a 417-amino acid, 48-kD polypeptide that migrates aberrantly at 60 kD by SDS-PAGE. Rabbit antibodies raised against this protein's recently described amino-terminal epitope react with a previously identified 52-kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs. Ultraviolet light cross-linking studies suggest that this Ro protein binds each of the four major human cytoplasmic RNAs. The deduced amino acid sequence is 63% homologous to an Onchocerca volvulus antigen. Southern filter hybridization analysis indicates that this gene is not highly polymorphic and exists as a single copy in the human genome. Chromosomal localization studies place this gene on the short arm of chromosome 19 near the gene encoding the low density lipoprotein receptor. Images PMID:2332496

  10. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension.

    PubMed

    Guerreso, Kelsey; Conner, Edward Alexander

    2016-01-01

    There are many different causes of pulmonary hypertension and the pathogenesis of the disease is still being elucidated. Although they are not the most common, autoimmunity and inflammation have been identified as possible causes. No one autoantibody has been identified as the definite cause of pulmonary hypertension. We present a rare association of anti-SSA/Ro antibodies and isolated pulmonary hypertension. A 53 year old African American female presented with abdominal pain, nausea, weight loss, dyspnea and fatigue. Upon further exam she was found to have high titers of antinuclear antibodies and anti-SSA/Ro antibodies. This antibody profile would typically be suggestive of Sjögren's Syndrome, which is characterized by dry eyes and poor salivary gland function. However, since this patient did not have any symptoms consistent with the disease a diagnosis of Sjögren's Syndrome could not be made. A combination of laboratory, imaging and diagnostic studies were done that revealed a final diagnosis of pulmonary hypertension. It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension.

  11. Spectral characterization and differential rotation study of active CoRoT stars

    NASA Astrophysics Data System (ADS)

    Nagel, E.; Czesla, S.; Schmitt, J. H. M. M.

    2016-05-01

    The CoRoT space telescope observed nearly 160 000 light curves. Among the most outstanding is that of the young, active planet host star CoRoT-2A. In addition to deep planetary transits, the light curve of CoRoT-2A shows strong rotational variability and a superimposed beating pattern. To study the stars that produce such an intriguing pattern of photometric variability, we identified a sample of eight stars with rotation periods between 0.8 and 11 days and photometric variability amplitudes of up to 7.5%, showing a similar CoRoT light curve. We also obtained high-resolution follow-up spectroscopy with TNG/SARG and carried out a spectral analysis with SME and MOOG. We find that the color dependence of the light curves is consistent with rotational modulation due to starspots and that latitudinal differential rotation provides a viable explanation for the light curves, although starspot evolution is also expected to play an important role. Our MOOG and SME spectral analyses provide consistent results, showing that the targets are dwarf stars with spectral types between F and mid-K. Detectable Li i absorption in four of the targets confirms a low age of 100-400 Myr also deduced from gyrochronology. Our study indicates that the photometric beating phenomenon is likely attributable to differential rotation in fast-rotating stars with outer convection zones.

  12. Variation in Herrnstein's ro as a function of alternative reinforcement rate

    PubMed Central

    Dougan, James D.; McSweeney, Frances K.

    1985-01-01

    In a test of Herrnstein's (1970, 1974) equation for simple schedules, 15 pigeons pecked a key that produced food delivered according to variable-interval schedules. One group of birds was water deprived, and food-reinforced key pecking occurred in the presence of free water. Two other groups were not water deprived; water was present for one and absent for the other. As predicted by Herrnstein, the parameter ro was significantly higher in the water-deprived group than in the two nondeprived groups. Contrary to Herrnstein's interpretation of ro, the rate of drinking varied across schedules. Herrnstein's interpretation can be salvaged by considering ro to be an average. However, if ro is an average, the equation is not a good explanation of behavior because this average is not valid until all schedules have been sampled. In addition, low percentages of variance accounted for suggest that Herrnstein's equation may be of limited usefulness even as a descriptive model for these situations. PMID:16812413

  13. Ro/SSA autoantibody-positive pregnancy: reactions to serial fetal Doppler echocardiographic surveillance.

    PubMed

    Tingström, J; Hjelmstedt, A; Welin Henriksson, E; Sonesson, S-E; Wahren-Herlenius, M

    2015-12-01

    The risk for congenital heart block (CHB) associated with maternal Ro/SSA autoantibodies is low, but the possibility of treating early stages of disease has seen the introduction of Doppler echocardiographic surveillance programs with serial examinations during the CHB susceptibility weeks of pregnancy. The aim of the present study was to understand how Ro/SSA autoantibody-positive women having undergone Doppler echocardiographic surveillance programs and giving birth to children without CHB experienced their pregnancy and frequent ultrasound examinations. A validated questionnaire based on data from an interview-study was distributed to Ro/SSA-positive women supervised with Doppler examinations during their pregnancy (n = 100). The response rate was 79%. The majority of the women (61%) reported that the increased number of ultrasound examinations influenced their pregnancy, but in a positive way, with qualified information and additional support from health care personnel in conjunction with the examinations. Further, the visits to the clinic provided opportunities to see the ultrasound picture of the expected infant. However, one-third of the women also reported stress in relation to the examinations. Fetal echocardiographic surveillance holds many and predominantly positive effects for Ro/SSA-positive women during pregnancy in addition to the medical advantages. © The Author(s) 2015.

  14. Tectonic and unroofing history of Neogene Manantiales foreland basin deposits, Cordillera Frontal (32°30'S), San Juan Province, Argentina

    NASA Astrophysics Data System (ADS)

    Pérez, Daniel J.

    2001-12-01

    The Miocene Manantiales foreland basin is located in Cordillera Frontal of San Juan, between 32°30' and 33°S. The unroofing study of the synorogenic Miocene deposits provides information about the structural evolution of Cordón de La Ramada fold-and-thrust belt. These Tertiary deposits are represented by the Chinches Formation and comprise seven members (Tc0-Tc6). They are the result of the uplift of Mesozoic sequences that crop out in La Ramada fold-and-thrust belt of the Cordillera Principal. Quaternary deposits unconformably overlying the Chinches Formation are composed of granitic and rhyolitic blocks, and represent the final uplift of the Cordón del Espinacito and a series of out-of-sequence thrusts. The unroofing studies also provide sufficient information to establish the out-of-sequence timing of the deformation at this latitude. Initial deposition of the Tertiary deposits can be dated at about 20 Ma, or early Miocene. Andesitic lavas dated in 9.2±0.3, 10.7±0.7, and 12.7±0.7 Ma unconformably overlie the structure of La Ramada fold-and-thrust belt. These facts constrain the uplift of the High Andes between 20 and 10 Ma at this latitude. The unconformity between Tertiary and Quaternary deposits suggests final uplift during Pliocene-Pleistocene times.

  15. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

    PubMed Central

    Liang, Yayun; Mafuvadze, Benford; Aebi, Johannes D; Hyder, Salman M

    2016-01-01

    Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration); however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4′-[6-(allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071) (RO), which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway), on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ) protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the growth of aggressive castration-resistant human prostate cancer cell xenografts in vivo without any signs of toxicity to experimental animals. Importantly, RO did not reduce the viability of normal prostate cells in vitro. Our study is the first to demonstrate that the cholesterol biosynthesis inhibitor RO effectively suppresses growth of human prostate cancer cells

  16. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells.

    PubMed

    Liang, Yayun; Mafuvadze, Benford; Aebi, Johannes D; Hyder, Salman M

    2016-01-01

    Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration); however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylamino)hexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071) (RO), which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway), on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ) protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the growth of aggressive castration-resistant human prostate cancer cell xenografts in vivo without any signs of toxicity to experimental animals. Importantly, RO did not reduce the viability of normal prostate cells in vitro. Our study is the first to demonstrate that the cholesterol biosynthesis inhibitor RO effectively suppresses growth of human prostate cancer cells. Our

  17. A New Method for Detecting and Monitoring Atmospheric Natural Hazards with GPS RO

    NASA Astrophysics Data System (ADS)

    Biondi, R.; Steiner, A. K.; Rieckh, T. M.; Kirchengast, G.

    2014-12-01

    Global Positioning System (GPS) Radio Occultation (RO) allows measurements in any meteorological condition, with global coverage, high vertical resolution, and high accuracy. With more than 13 years of data availability, RO also became a fundamental tool for studying climate change. We present here the application of RO for detecting and monitoring tropical cyclones (TCs), deep convective systems (CSs) and volcanic ash clouds (ACs).Deep CSs and TCs play a fundamental role in atmospheric circulation producing vertical transport, redistributing water vapor and trace gases, changing the thermal structure of the Upper Troposphere and Lower Stratosphere (UTLS) and affecting climate through overshooting into the stratosphere. Explosive volcanic eruptions produce large ACs dangerous for the aviation and they can impact climate when the ash is injected into the UTLS.The detection of cloud top height, the determination of cloud extent, the discrimination of ACs from CSs clouds and the detection of overshooting are main challenges for atmospheric natural hazards study. We created a reference atmosphere with a resolution of 5° in latitude and longitude, sampled on a 1° x 1° grid, and a vertical sampling of 100 m. We then compared RO profiles acquired during TCs, CSs and ACs to the reference atmosphere and computed anomaly profiles.CSs, TCs and the ACs leave a clear signature in the atmosphere which can be detected by RO. Using RO temperature and bending angle profiles we gain insight into the vertical thermal structure and developed a new method for detecting the cloud top altitude with high accuracy.We have characterized the TCs by ocean basins and intensities, showing that they have a different thermal structure and reach to different altitudes according to the basin. We provide statistics on overshooting frequency, achieving results consistent with patterns found in the literature and demonstrating that RO is well suited for this kind of study. We have analyzed the

  18. [The life of Dr. RO Kishun, a reflection of modern Korean medical history of the borders].

    PubMed

    Shin, Young-Jeon; Park, Se-Hong

    2009-06-01

    RO Kishun was born on February 2, 1893 in Ongjin County, Hwanghae Province of Joseon Korea. He graduated from the Medical Training Center, a campus associated with the Joseon Government-General Hospital, in 1915, and from Kyushu Imperial University School of Medicine in 1917. He continued his medical study at the university in 1929, majoring in biochemistry, and earned a doctorate in medicine in 1932. Dr. RO, one of the earliest pioneers in Korean biochemistry, was active in his research, publishing four studies in the Japanese Journal of Biochemistry between 1931 and 1932. After returning from Japan in 1932, Dr. RO opened a medical practice in Mokpo and Busan, port cities situated on the southern tip of Korea. Later in 1936, he moved north to Manchuria (northeast China) to practice medicine at the International Hospital in Mukden (present-day Shenyang). He also served as president of Tumen Public Hospital between 1942 and 1946. When Japan signed unconditional surrender bringing World War II to an end, Dr. RO relocated to Yanbian and began providing medical training to ethnic Koreans. In October 1946, he was appointed dean of the First Branch School of China Medical University in Longjing, and in October 1948 the first dean of Yanbian Medical School, the predecessor of Yanbian University College of Medicine. Dr. RO dedicated his life to medical practice, teaching and training students, and mentoring younger faculty. A brilliant clinician, he also inspired and helped his colleagues with his outstanding ability to diagnose and treat patients. He was one of the founding members of Yanbian University College of Medicine. RO Kishun died on June 7, 1957 at age 64. Ethnic Koreans hailed him as Sinui (literally, the physician of God), and a bronze statue of himself was erected in front of the medical college in 1988. Dr. RO's life brings modern historians' attention to the issue of determining geographical territories and nationality, in that his life unfolded at the

  19. [Detection of anti-SSA/Ro antibody by ELISA, double immunodiffusion, and immunoblotting: a comparative study].

    PubMed

    Tong, Sheng-quan; Shi, Qun; Wen, Xiao-hong; Gan, Xiao-dan; Shi, Yan-ping; Zhao, Yan; Zeng, Xiao-feng; Zhang, Feng-chun; Dong, Yi

    2006-09-19

    To compare the specificity and sensitivity of ELISA, double immunodiffusion (ID), and immunoblotting (IB) in detection of anti-SSA/Ro antibodies in the sera of patients with connective tissue disease (CTD). ELISA, double ID, and IB were used to detect the serum levels of anti-SSA/Ro antibodies in 7736 patients undergoing screening of CTD, 122 healthy blood donors, and 166 CTD patients positive in antinuclear antibody (ANA) and/or anti-extractable nuclear antigen (ENA). (1) The sera of the 122 healthy blood donors were all negative in anti-SSA/Ro antibodies by these three methods. (2) 1085 of the 7736 sera undergoing screening of CTD were positive in the anti-SSA/R0 antibody of the relative molecular quantity of 52,000. Ninety-two of the 1085 patient, ANA and/or anti-ENA negative, were all confirmed by ELISA and ID to be negative in anti-SSA/R0 antibodies. And 993 of these 1085 patients were positive in ANA and/or anti-ENA antibody, 917 of which were shown to be anti-SSA/R0 antibodies positive by ELISA (92.3%, 917/993), and 860 of which were shown to be anti-SSA/R0 antibodies positive by ID (86.6%, 860/993). (3) The prevalence rates of anti-SSA/Ro antibodies in the 166 CTD patients detected by ELISA, ID, and IB respectively were 76.5% (127/166), 65.1% (108/166), and 49.4% (82/166) respectively. (4) 127 of the 166 sera of the CTD group were anti-SSA/Ro antibody positive By ELISA, and 108 of the 166 sera were anti-SSA/R0 antibody positive by ID, with a coincidence rate of ELISA and ID of 88.6% (147/166), and there was a significant difference in positive rate of anti-SSA/Ro antibody between these two methods (P < 0.001). 81 of the 166 CTD sera were anti-SSA/Ro antibody positive with a positive rate of 63.8%. The coincidence rate of ID and IB was 75.9% (126/166) and there was a significant difference in positive rate of anti-SSA/Ro antibody between ID and IB methods too (P < 0.001). (5) Spearman's rank correlation study showed that the correlation coefficient between

  20. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.

    PubMed

    Debeb, Bisrat G; Cohen, Evan N; Boley, Kimberly; Freiter, Erik M; Li, Li; Robertson, Fredika M; Reuben, James M; Cristofanilli, Massimo; Buchholz, Thomas A; Woodward, Wendy A

    2012-07-01

    Basal breast cancer, common among patients presenting with inflammatory breast cancer (IBC), has been shown to be resistant to radiation and enriched in cancer stem cells. The Notch pathway plays an important role in self-renewal of breast cancer stem cells and contributes to inflammatory signaling which promotes the breast cancer stem cell phenotype. Herein, we inhibited Notch signaling using a gamma secretase inhibitor, RO4929097, in an in vitro model that enriches for cancer initiating cells (3D clonogenic assay) and conventional 2D clonogenic assay to compare the effect on radiosensitization of the SUM149 and SUM190 IBC cell lines. RO4929097 downregulated the Notch target genes Hes1, Hey1, and HeyL, and showed a significant reduction in anchorage independent growth in SUM190 and SUM149. However, the putative self-renewal assay mammosphere formation efficiency was increased with the drug. To assess radiosensitization of putative cancer stem cells, cells were exposed to increasing doses of radiation with or without 1 μM RO4929097 in their standard (2D) and self-renewal enriching (3D) culture conditions. In the conventional 2D clonogenic assay, RO4929097 significantly sensitized SUM190 cells to ionizing radiation and has a modest radiosensitization effect in SUM149 cells. In the 3D clonogenic assays, however, a radioprotective effect was seen in both SUM149 and SUM190 cells at higher doses. Both cell lines express IL-6 and IL-8 cytokines known to mediate the efficacy of Notch inhibition and to promote self-renewal of stem cells. We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-α, a potential mediator of IL-6 and IL-8 production in the microenvironment. These data suggest that additional targeting agents may be required to selectively target IBC stem cells through Notch inhibition, and that evaluation of microenvironmental influences may shed further light on the potential effects of this inhibitor.

  1. A Phase II Study of RO4929097 Gamma-Secretase Inhibitor in Metastatic Melanoma: SWOG 0933

    PubMed Central

    Lee, Sylvia M.; Moon, James; Redman, Bruce G.; Chidiac, Tarek; Flaherty, Lawrence E.; Zha, Yuanyuan; Othus, Megan; Ribas, Antoni; Sondak, Vernon K.

    2014-01-01

    Background Aberrant Notch activation confers a proliferative advantage onto many human tumors, including melanoma. This phase II trial assessed the antitumor activity of RO4929097, a gamma-secretase inhibitor of Notch signaling, on the progression-free and overall survival of patients with advanced melanoma. Methods Chemotherapy-naïve patients with metastatic melanoma of cutaneous or unknown origin were treated with RO4929097 at a dose of 20 mg orally daily, 3 consecutive days per week. A two-step accrual design was used, with an interim analysis on the first 32 patients, and continuation of enrollment if ≥4/32 patients responded. Results Thirty-six patients from 23 institutions were enrolled; 32 patients were evaluable. RO4929097 was well-tolerated, and most toxicities were grade 1 or 2. The most common toxicities were nausea (53%), fatigue (41%), and anemia (22%). There was 1 confirmed partial response lasting 7 months, and 8 patients with stable disease lasting at least through week 12, with one of these continuing for 31 months. The 6-month PFS was 9% (95% CI: 2–22%), and 1-year OS was 50% (95% CI: 32–66%). Peripheral blood T cell assays showed no significant inhibition of IL-2 production, a surrogate pharmacodynamic marker of Notch inhibition, suggesting that the drug levels were insufficient to achieve Notch target inhibition. Conclusions RO4929097 showed minimal clinical activity against metastatic melanoma in this phase II trial, possibly due to inadequate exposure to therapeutic drug levels. While Notch inhibition remains a compelling target in melanoma, our results do not support further investigation of RO4929097 at this dose and schedule. PMID:25250858

  2. Expression of the Memory Marker CD45RO on Helper T Cells in Macaques

    PubMed Central

    Valentine, Michael; Song, Kejing; Maresh, Grace A.; Mack, Heather; Huaman, Maria Cecilia; Polacino, Patricia; Ho, On; Cristillo, Anthony; Kyung Chung, Hye; Hu, Shiu-Lok; Pincus, Seth H.

    2013-01-01

    Background In humans it has been reported that a major site of the latent reservoir of HIV is within CD4+ T cells expressing the memory marker CD45RO, defined by the mAb UCHL1. There are conflicting reports regarding the expression of this antigen in macaques, the most relevant animal species for studying HIV pathogenesis and testing new therapies. There is now a major effort to eradicate HIV reservoirs and cure the infection. One approach is to eliminate subsets of cells housing the latent reservoir, using UCHL1 to target these cells. So that such studies may be performed in macaques, it is essential to determine expression of CD45RO. Methods We have used immunofluorescence and flow cytometry to study cell surface expression of CD45RO on lymphocytes from PBMC, lymphoid, and GI organs of rhesus, pigtailed, and cynomolgus macaques. Both direct and indirect immunofluorescence experiments were performed. Findings CD45RO is expressed on a subset of CD4+ lymphocytes of all pigtailed, a fraction of rhesus, and neither of the cynomolgus macaques studied. The binding of UCHL1 to macaque cells was of lower avidity than to human cells. This could be overcome by forming UCHL1 multimers. Directly conjugating fluors to UCHL1 can inhibit UCHL1 binding to macaque cells. Patterns of UCHL1 expression differ somewhat in macaques and humans, and from that of other memory markers often used in macaques. Conclusions CD45RO, defined with mAb UCHL1, is well expressed on CD4+ cells in pigtailed macaques. Using tissues recovered from latently infected pigtailed macaques we are determining whether UCHL1, or other memory markers, can define the cellular locus of the reservoir. The low avidity of this interaction could limit the utility of UCHL1, in its conventional form, to eliminate cells in vivo and test this approach in macaque models of HIV infection. PMID:24023920

  3. [Neonatal lupus and maternofetal transmission of anti-SSA/Ro and anti-SSB/La antibodies].

    PubMed

    Feki, S; Turki, A; Frikha, F; Hachicha, H; Walha, L; Gargouri, A; Bahloul, Z; Masmoudi, H

    2015-02-01

    Neonatal lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro (60 and 52kDa) or anti-SSB/La antibodies. The aim of this study was to evaluate the clinical and biological profile of NL at the neonatal unit of Sfax, Tunisia, over a 10-year period. Six mother-NB pairs (two sets of twins and two sisters) had positive ANA by transplacental transmission during the study period. The ANA pattern was speckled and the NBs' sera titer was half that of their mothers'. Anti-SSA, anti-Ro52, and anti-SSB were found in 100%, 33%, and 50% of the mothers' sera, respectively. The transmission of anti-SSA was observed in four pregnancies out of six, anti-Ro52 in two pregnancies out of two, and anti-SSB in one pregnancy out of three. The patients' clinical records showed that two NBs had a congenital heart block: one with anti-SSA, whose mother had Sjögren syndrome, and another with anti-SSA, anti-SSB, anti-Ro52, and anti-mitochondrial antibodies (M2 type), whose mother had no diagnosis at the child's birth (cutaneous erythema and positive ANA with the same profile). Cutaneous signs (erythema, petechia) were described in three NBs out of six. The two sets of fraternal twins had cutaneous signs with the same ANA titer and profile (no anti-SSA transmission from their mother with lupus and anti-phospholipid syndrome). The two sisters' (two pregnancies 3 years apart) mother had Sjögren syndrome, one of them had heart block with positive anti-SSA, and the other was asymptomatic with anti-SSA and anti-Ro52. The same mother had a history of three pregnancies with two NBs who died of heart block. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  4. Prolonged corrected QT interval in anti-Ro/SSA-positive adults with systemic lupus erythematosus.

    PubMed

    Bourré-Tessier, Josiane; Clarke, Ann E; Huynh, Thao; Bernatsky, Sasha; Joseph, Lawrence; Belisle, Patrick; Pineau, Christian A

    2011-07-01

    To examine whether anti-Ro/SSA antibodies are associated with an increased risk of corrected QT (QTc) prolongation, and to study the stability of this relationship over time. Patients fulfilling the American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE) were invited to undergo a 12-lead resting electrocardiogram (EKG) in the pilot phase of our project, performed between February 2002 and March 2005. The same study population was used to perform a second similar analysis with a larger sample between April 2005 and May 2007. Multivariate logistic regression models were fit to estimate the cross-sectional association between anti-Ro/SSA and other demographic and clinical variables on QTc prolongation. The other potentially associated factors examined included age, sex, disease duration, lupus activity (Systemic Lupus Erythematosus Disease Activity Index 2000 update), damage (Systemic Lupus International Collaborating Clinics/ACR Damage Index), potassium and magnesium levels, and medications with the potential to prolong the QTc interval. Cross-sectional analysis of the pilot data (n = 150 patients) showed an association of prolonged QTc with the presence of anti-Ro/SSA (adjusted odds ratio [OR] 12.6; 95% confidence interval [95% CI] 2.3, 70.7). In the second larger study (n = 278), the association was replicated, with a narrower 95% CI (adjusted OR 5.1; 95% CI 1.5, 17.4). In the 118 patients with 2 EKG assessments, the results were consistent over time. Anti-Ro/SSA was associated with QTc prolongation in both our pilot data and a larger SLE cohort sample. Patients positive for anti-Ro/SSA may benefit from EKG testing and appropriate counseling should be considered for those identified with QTc prolongation. Copyright © 2011 by the American College of Rheumatology.

  5. [Dietary prescriptions for the elites of the kingdom of Navarre in the 16th century: the cases of Juan Rena and Juan de Alarcón].

    PubMed

    Serrano Larráyoz, Fernando

    2014-01-01

    The aim of this article is to present and analyse four dietary prescriptions from the 16th century prepared for Juan Rena, a cleric of Venetian origin, and his servant Juan de Alarcón, which are kept at the Archivo General de Navarra. These documents demonstrate the interest of the patients and physicians in dietetics, understood as a group of health and hygienic measures based on the Galenic res naturales and res non naturales. These four prescriptions are closely related to the ad personam or consilia health regimens, which represent a genre of medical literature whose significance in Renaissance Spain has received little attention. The cases studied reveal the high esteem in which the elites held the possession of therapeutic resources adapted to their individual needs, which were compiled and copied for personal use.

  6. Anti-Ro/SSA-associated corrected QT interval prolongation in adults: the role of antibody level and specificity.

    PubMed

    Lazzerini, Pietro Enea; Capecchi, Pier Leopoldo; Acampa, Maurizio; Morozzi, Gabriella; Bellisai, Francesca; Bacarelli, Maria Romana; Dragoni, Saverio; Fineschi, Irene; Simpatico, Antonella; Galeazzi, Mauro; Laghi-Pasini, Franco

    2011-10-01

    Recent evidence suggests that anti-Ro/SSA antibodies, strongly associated with the development of congenital heart block, may also be arrhythmogenic for the adult heart. In fact, anti-Ro/SSA-positive patients with connective tissue disease (CTD) frequently display corrected QT (QTc) prolongation associated with an increase in ventricular arrhythmias. However, QTc prolongation prevalence markedly differs throughout the studies (10-60%), but the reason why is not yet clear. The aim of this study was to evaluate whether anti-Ro/SSA-associated QTc prolongation in adult patients with CTD is related to antibody level and specificity. Forty-nine adult patients with CTD underwent a resting 12-lead electrocardiogram recording to measure QTc interval, and a venous withdrawal to determine anti-Ro/SSA antibody level and specificity (anti-Ro/SSA 52 kd and anti-Ro/SSA 60 kd) by immunoenzymatic methods and Western blotting. In our population, a direct correlation was demonstrated between anti-Ro/SSA 52-kd level and QTc duration (r = 0.38, P = 0.007), patients with a prolonged QTc had higher levels of anti-Ro/SSA 52 kd with respect to those with a normal QTc (P = 0.003), and patients with a moderate to high level (≥50 units/ml) of anti-Ro/SSA 52 kd showed a longer QTc interval (P = 0.008) and a higher QTc prolongation prevalence (P = 0.008) than those with a low positive/negative level (<50 units/ml). On the contrary, no association was found between QTc and anti-Ro/SSA 60-kd level. In anti-Ro/SSA-positive adult patients with CTD, the occurrence of QTc prolongation seems strictly dependent on the anti-Ro/SSA 52-kd level. This finding, possibly explaining the different QTc prolongation prevalence reported, strengthens the hypothesis that an extremely specific autoimmune cross-reaction is responsible for the anti-Ro/SSA-dependent interference on ventricular repolarization. Copyright © 2011 by the American College of Rheumatology.

  7. A deeper view of the CoRoT-9 planetary system. A small non-zero eccentricity for CoRoT-9b likely generated by planet-planet scattering

    NASA Astrophysics Data System (ADS)

    Bonomo, A. S.; Hébrard, G.; Raymond, S. N.; Bouchy, F.; Lecavelier des Etangs, A.; Bordé, P.; Aigrain, S.; Almenara, J.-M.; Alonso, R.; Cabrera, J.; Csizmadia, Sz.; Damiani, C.; Deeg, H. J.; Deleuil, M.; Díaz, R. F.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Guenther, E.; Guillot, T.; Hatzes, A.; Izidoro, A.; Lovis, C.; Moutou, C.; Ollivier, M.; Pätzold, M.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.

    2017-07-01

    CoRoT-9b is one of the rare long-period (P = 95.3 days) transiting giant planets with a measured mass known to date. We present a new analysis of the CoRoT-9 system based on five years of radial-velocity (RV) monitoring with HARPS and three new space-based transits observed with CoRoT and Spitzer. Combining our new data with already published measurements we redetermine the CoRoT-9 system parameters and find good agreement with the published values. We uncover a higher significance for the small but non-zero eccentricity of CoRoT-9b () and find no evidence for additional planets in the system. We use simulations of planet-planet scattering to show that the eccentricity of CoRoT-9b may have been generated by an instability in which a 50 M⊕ planet was ejected from the system. This scattering would not have produced a spin-orbit misalignment, so we predict that the CoRoT-9b orbit should lie within a few degrees of the initial plane of the protoplanetary disk. As a consequence, any significant stellar obliquity would indicate that the disk was primordially tilted.

  8. Holocene compression in the Acequión valley (Andes Precordillera, San Juan province, Argentina): Geomorphic, tectonic, and paleoseismic evidence

    NASA Astrophysics Data System (ADS)

    Audemard, M.; Franck, A.; Perucca, L.; Laura, P.; Pantano, Ana; Avila, Carlos R.; Onorato, M. Romina; Vargas, Horacio N.; Alvarado, Patricia; Viete, Hewart

    2016-04-01

    The Matagusanos-Maradona-Acequión Valley sits within the Andes Precordillera fold-thrust belt of western Argentina. It is an elongated topographic depression bounded by the roughly N-S trending Precordillera Central and Oriental in the San Juan Province. Moreover, it is not a piggy-back basin as we could have expected between two ranges belonging to a fold-thrust belt, but a very active tectonic corridor coinciding with a thick-skinned triangular zone, squeezed between two different tectonic domains. The two domains converge, where the Precordillera Oriental has been incorporated to the Sierras Pampeanas province, becoming the western leading edge of the west-verging broken foreland Sierras Pampeanas domain. This latter province has been in turn incorporated into the active deformation framework of the Andes back-arc at these latitudes as a result of enhanced coupling between the converging plates due to the subduction of the Juan Fernández ridge that flattens the Nazca slab under the South American continent. This study focuses on the neotectonics of the southern tip of this N-S elongated depression, known as Acequión (from the homonym river that crosses the area), between the Del Agua and Los Pozos rivers. This depression dies out against the transversely oriented Precordillera Sur, which exhibits a similar tectonic style as Precordillera Occidental and Central (east-verging fold-thrust belt). This contribution brings supporting evidence of the ongoing deformation during the Late Pleistocene and Holocene of the triangular zone bounded between the two leading and converging edges of Precordillera Central and Oriental thrust fronts, recorded in a multi-episodic lake sequence of the Acequión and Nikes rivers. The herein gathered evidence comprise Late Pleistocene-Holocene landforms of active thrusting, fault kinematics (micro-tectonic) data and outcrop-scale (meso-tectonic) faulting and folding of recent lake and alluvial sequences. In addition, seismically

  9. Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    NASA Astrophysics Data System (ADS)

    Rouan, D.; Parviainen, H.; Moutou, C.; Deleuil, M.; Fridlund, M.; Ofir, A.; Havel, M.; Aigrain, S.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cabrera, J.; Cavarroc, C.; Csizmadia, Sz.; Deeg, H. J.; Diaz, R. F.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Gandolfi, D.; Gillon, M.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Samuel, B.; Santerne, A.; Schneider, J.; Tingley, B.; Wuchterl, G.

    2012-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search for possible background eclipsing binaries conducted at CFHT and OGS concluded with a very low risk of false positives. The usual techniques of combining RV and transit data simultaneously were used to derive stellar and planetary parameters. The planet has a mass of Mp = 2.8 ± 0.3 MJup, a radius of Rpl= 1.05 ± 0.13RJup, a density of ≈ 3 g cm-3. RV data also clearly reveal a nonzero eccentricity of e = 0.16 ± 0.02. The planet orbits a mature G0 main sequence star of V = 15.5 mag, with a mass M⋆ = 1.14 ± 0.08 M⊙, a radius R ⋆ = 1. 61 ± 0.18 R⊙ and quasi-solarabundances. The age of the system is evaluated to be 7 Gyr, not far from the transition to subgiant, in agreement with the rather large stellar radius. The two features of a significant eccentricity of the orbit and of a fairly high density are fairly uncommon for a hot Jupiter. The high density is, however, consistent with a model of contraction of a planet at this mass, given the age of the system. On the other hand, at such an age, circularization is expected to be completed. In fact, we show that for this planetary mass and orbital distance, any initial eccentricity should not totally vanish after 7 Gyr, as long as the tidal quality factor Qp is more than a few 105, a value that is the lower bound of the usually expected range. Even if CoRoT-23b features a density and an eccentricity that are atypical of a hot Jupiter, it is thus not an enigmatic object. The CoRoT space mission, launched on 27 December 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. First CoRoT data are available to the public from the CoRoT archive: http

  10. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

    SciTech Connect

    Espinosa, Alexander; Oke, Vilija; Elfving, Ase; Nyberg, Filippa; Covacu, Ruxandra; Wahren-Herlenius, Marie

    2008-12-10

    Patients with the systemic autoimmune diseases Sjoegrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1. While Ro52 and UBE2D1 are cytoplasmic proteins, UBE2E1 is localized to the nucleus. Here, we investigate how domains of human Ro52 regulate its intracellular localization. By expressing fluorescently labeled Ro52 and Ro52 mutants in HeLa cells, an intact coiled-coil domain was found to be necessary for the cytoplasmic localization of Ro52. The amino acids 381-470 of the B30.2 region were essential for translocation into the nucleus. Furthermore, after exposure of HeLa cells to the inflammatory mediator nitric oxide (NO), Ro52 translocated to the nucleus. A nuclear localization of Ro52 in inflamed tissue expressing inducible NO synthetase (iNOS) from cutaneous lupus patients was observed by immunohistochemistry and verified in NO-treated cultures of patient-derived primary keratinocytes. Our results show that the localization of Ro52 is regulated by endogenous sequences, and that nuclear translocation is induced by an inflammatory mediator. This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus.

  11. Water column hydrothermal plumes on the Juan de Fuca Ridge

    SciTech Connect

    Lupton, J.E. )

    1990-08-10

    Hydrographic surveys on the Juan de Fuca Ridge (JdFR) carried out from 1980 to 1987 show a complex pattern of {sup 3}He and Mn-rich water column plumes produced by venting from several submarine hot spring areas. In the vicinity of Axial Volcano at latitude 46{degree}N, distinct plumes were detected in 1980, 1982, and 1983 with {sup 3}He signatures up to {delta}({sup 3}He) = 64% at {approximately} 1,500 m depth at distances of {approximately} 10 km from the seamount summit. However, the same plumes had no detectable thermal signature, a paradox which is attributed to the high {sup 3}He/heat ratios and low salinities of the fluids venting within the caldera of Axial Volcano. Profiles directly over the seamount show hydrothermal {sup 3}He in the water column up to 300 m above the caldera floor, with the {sup 3}He signal increasing with depth to very high and uniform ratios of {delta}({sup 3}He) = 108-150% below the {approximately} 1,500-m caldera sill depth. Another apparent locus of hydrothermal input is Helium Basin, a depression on the northeast flank of Axial Volcano which had {delta}({sup 3}He) = 51% when first sampled in 1980. However, subsequent hydrocasts into Helium Basin in 1982 and 1983 yielded lower helium enrichments, suggesting either a decrease in hydrothermal input or flushing of the basin via a mixing event. To the south of Axial Volcano, high {delta}({sup 3}He) values of {approximately} 40% observed over the ridge axis at 45{degree}18{prime}N and 45{degree}39{prime}N indicate venting on this previously unexplored section of the ridge. The water column plumes over the US Geological Survey vent site at {approximately} 44{degree}40{prime}N on the southern JdFR have very high Mn/{sup 3}He ratios of 4,600 mol/cm{sup 3}, an apparently unique characteristic which can be used to distinguish these plumes from those originating at other JdFR vent fields.

  12. Analysis of Pn Anisotropy Beneath the Juan de Fuca Plate

    NASA Astrophysics Data System (ADS)

    VanderBeek, B. P.; Toomey, D. R.

    2016-12-01

    We use Pn phases from 40 earthquakes located along the Blanco Transform Fault and the northern Juan de Fuca (JdF) Ridge to constrain the magnitude and orientation of shallow mantle anisotropy beneath the JdF plate. Data are recorded on the year 3 deployment of Cascadia Initiative ocean bottom seismometers (OBSs) and a complimentary array of OBSs located along the Blanco Transform Fault. Nearly 1000 hand-picked Pn arrivals provide complete coverage of the JdF plate. Using a subset of our Pn dataset, we relocated the Blanco events used in this study. Mantle velocities are computed from Pn delay times using the updated source parameters. We find that the best-fit fast-axis azimuth of shallow mantle anisotropy is 92 ± 1°, with a magnitude of 4 ± 1% and a mean velocity of 7.8 km/s (Fig. 1). The observed orientation of anisotropy is rotated 11° counterclockwise to the mean paleo-spreading direction sampled by our dataset. Our results compliment previous measurements of shallow mantle anisotropy beneath the JdF Ridge [VanderBeek et al., 2016] and asthenospheric anisotropy beneath the JdF plate [Bodmer et al., 2015]. Together, these observations provide constraints on mantle deformation across multiple scales and depths. Surprisingly, the seismically inferred orientations of mantle divergence beneath the JdF Ridge and the direction of asthenospheric flow beneath the plate interior from SKS splitting are rotated ahead of recent clockwise changes in JdF plate motion. In comparison, Pn anisotropy averaged across the JdF plate trends between the inferred directions of mantle flow at the ridge and beneath the plate interior. Our results indicate that shallow mantle anisotropy continues to evolve off-axis as the mantle flow field transitions from divergence near the ridge to simple shear that is more closely aligned with absolute plate motion. Moreover, all measurements of anisotropy across the JdF plate indicate that asthenospheric flow is driven by more than plate motion.

  13. Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.

    PubMed

    Martínez-Sánchez, Nuria; Pérez-Pinto, Sergio; Robles-Marhuenda, Ángel; Arnalich-Fernández, Francisco; Martín Cameán, María; Hueso Zalvide, Edurne; Bartha, Jose Luis

    2017-04-01

    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed. Forty-two anti-Ro/SSA antibodies positive pregnant women that were referred to our hospital between 2011 and 2015. Data about pregnancy follow-up and outcomes were prospectively recorded from electronic databases. Data included demographic characteristics of the patients and their diseases (type, treatments, profile of anti-Ro/SSA, and antiphospholipid antibodies), pregnancy complications (CHB, preeclampsia, preterm delivery), ultrasound examinations and conditions, and mode of delivery. Maternal age was 35.22 ± 3.42 years and most of them were either SLE (n = 16, 40%) or Sjögren syndrome (n = 15, 37.5%). The rest of them were asymptomatic carriers (n = 8; 20%), and there was only one case of rheumatoid arthritis (n = 1; 2.5%). The incidence of anti-Ro52 and anti-Ro60 positive was n = 13, 82.4% and n = 16, 100%, respectively. Anti-La/SSB antibodies were present in n = 17, 48,6% of the patients. Half of the patients were taking hydroxycloroquine (n = 18, 45%). Seven pregnancies were complicated by fetal anti-Ro-related cardiac disease (17.9%) including four cases (57.1%) of second-degree heart block, two cases of third degree heart block (28.6%) and one case (14.3%) of intense and diffuse hyperechogenicity in atrioventricular valves without heart block. Gestational age at diagnosis of these conditions was 23.2 ± 3.5 weeks. One of the 18 patients having hydroxychloroquine (5.6%) compared with the six of them in women not having this medication (6

  14. Preliminary data report for the San Juan Basin-Crownpoint surveillance study

    USGS Publications Warehouse

    Frenzel, Peter F.; Craigg, Steven D.; Padgett, Elizabeth T.

    1981-01-01

    Geohydrologic data that may be used to predict the effects of mining on Navajo water resources in the San Juan structural basin are reported as well as the current availability of data from other government agencies. Emphasis is on the vicinity of Crownpoint, New Mexico. (USGS)

  15. Juan Rulfo and Machado de Assis: Toward an Integrated New Narrative

    ERIC Educational Resources Information Center

    Wiseman, David P.; Krause, James R.

    2016-01-01

    Despite apparent connections between Brazilian and Spanish American narratives, comparative scholarship has only recently begun to investigate actively these important points of contact. In this study, we introduce a vital crossover between the two traditions, involving Juan Rulfo and Joaquim Maria Machado de Assis. Rulfo's outspoken affinity for…

  16. 77 FR 33239 - Prairie Stewardship Plan/Environmental Impact Statement, San Juan Island National Historical Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... National Park Service Prairie Stewardship Plan/Environmental Impact Statement, San Juan Island National Historical Park AGENCY: National Park Service, Interior. ACTION: Notice of Intent to Prepare an Environmental.... SUMMARY: Pursuant to the National Environmental Policy Act of 1969, 42 U.S.C. 4332(2)(C), the National...

  17. Hurricane recovery at Cabezas de San Juan, Puerto Rico, and research opportunities at Conservation Trust Reserves

    Treesearch

    Peter L. Weaver; Elizabeth Padilla Rodriguez

    2009-01-01

    The Cabezas de San Juan Natural Reserve (El Faro), an exposed peninsular area located in the Subtropical dry forest of northeastern Puerto Rico, was impacted by hurricanes Hugo (1989) and Georges (1998). From 1998 to 2008, a 0.10 ha plot was used to assess forest structure, species composition, and stem growth. During post-hurricane recovery, stem density, tree height...

  18. U.S. EPA Statement on San Juan River Data from Gold King Mine Release

    EPA Pesticide Factsheets

    SHIPROCK, NEW MEXICO - Today, U.S. EPA released additional water quality data from Aug. 7 to Aug. 9, 2015, on the San Juan River between Farmington and Shiprock, New Mexico. The August 7 data was collected for baseline purposes to understand river c

  19. 76 FR 70703 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Application for Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... Foreign-Trade Zones Board Foreign-Trade Zone 61--San Juan, Puerto Rico; Application for Expansion An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Puerto Rico Trade and..., Puerto Rico. The application was submitted pursuant to the provisions of the Foreign-Trade Zones Act, as...

  20. Lightcurves from the Archive: 1090 Sumida, 2284 San Juan, and 3493 Stepanov

    NASA Astrophysics Data System (ADS)

    Lang, Kim

    2017-01-01

    Three asteroids were observed briefly between other projects in 2015 March and April. The lightcurves of 1090 Sumida and 3493 Stepanov shows amplitudes of A = 0.30 and A = 0.95 mag. For 2284 San Juan, a synodic period of P = 9.18 h and amplitude of A = 0.69 mag were found.

  1. Seismic refraction studies in the San Juan Basin, Northwest New Mexico

    USGS Publications Warehouse

    Evans, D.H.; Jaksha, L.H.

    1984-01-01

    The U.S. Geological Survey is studying some of the features of the earth's crust in the San Juan Basin region, northwest New Mexico. As a part of this study seismic refraction-reflection measurements were made in and around the basin using explosions and earthquakes as energy sources. Record sections and traveltime tables were derived from the measurements.

  2. Mediated Debate, Historical Framing, and Public Art: The Juan de Onate Controversy in El Paso

    ERIC Educational Resources Information Center

    Perez, Frank G.; Ortega, Carlos F.

    2008-01-01

    In 1988, the El Paso, Texas, city council accepted a proposal to build twelve statues of historically important individuals as part of a downtown revitalization initiative. Juan de Onate was selected as the centerpiece statue of the XII Travelers Memorial of the Southwest. The decision to honor the Spanish colonizer triggered a local controversy…

  3. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    ERIC Educational Resources Information Center

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  4. San Juan, Puerto Rico Agrees to Make Investments in Clean Water

    EPA Pesticide Factsheets

    (New York, N.Y.) Under a settlement with the U.S. Department of Justice and the U.S. Environmental Protection Agency, the Municipality of San Juan has agreed to make substantial upgrades to its storm sewer systems throughout the city. The upgrades and rela

  5. 77 FR 52310 - Expansion of Foreign-Trade Zone 61, San Juan, Puerto Rico

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 61, San Juan, Puerto Rico Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign...

  6. Mediated Debate, Historical Framing, and Public Art: The Juan de Onate Controversy in El Paso

    ERIC Educational Resources Information Center

    Perez, Frank G.; Ortega, Carlos F.

    2008-01-01

    In 1988, the El Paso, Texas, city council accepted a proposal to build twelve statues of historically important individuals as part of a downtown revitalization initiative. Juan de Onate was selected as the centerpiece statue of the XII Travelers Memorial of the Southwest. The decision to honor the Spanish colonizer triggered a local controversy…

  7. 75 FR 54377 - Cattle Point Road Relocation; Draft Environmental Impact Statement; San Juan Island National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... environmental impact statement (DEIS) for alternatives designed to respond to coastal bluff erosion which... on the southeastern tip of San Juan Island is threatened by coastal erosion at the base of the slope... Conservation Area, managed by the Washington Department of Natural Resources (DNR). If erosion continues...

  8. Juan Rulfo and Machado de Assis: Toward an Integrated New Narrative

    ERIC Educational Resources Information Center

    Wiseman, David P.; Krause, James R.

    2016-01-01

    Despite apparent connections between Brazilian and Spanish American narratives, comparative scholarship has only recently begun to investigate actively these important points of contact. In this study, we introduce a vital crossover between the two traditions, involving Juan Rulfo and Joaquim Maria Machado de Assis. Rulfo's outspoken affinity for…

  9. Seismic Anisotropy below the Juan De Fuca Plate: Results from the Cascadia Initiative

    NASA Astrophysics Data System (ADS)

    Martin-Short, R.; Allen, R. M.; Bastow, I. D.

    2014-12-01

    Investigation of seismic anisotropy using shear wave splitting is typically used to infer information about asthenospheric flow geometry. In order to understand how such flow varies below the Juan de Fuca plate and is affected by its subduction along the Cascadia forearc, stacked splitting results are determined for 90 offshore and 27 onshore broadband seismometers. These instruments were deployed as part of phases one and two of the Cascadia Initiative, which is an ongoing effort to understand tectonic processes in the Pacific Northwest. The onshore results conform to those of previous studies, suggesting a uniformly trench-perpendicular flow field and thus implying a thick layer of material entrained beneath the slab. The offshore results offer suggestions about how the orientation of asthenospheric flow evolves across the width of the Juan de Fuca plate, and are unique in that they document variation in anisotropy from the ridge to the trench. The results indicate ridge-perpendicular flow geometry close to the Juan de Fuca ridge, which appears to rotate towards the direction of absolute plate motion as one moves towards the trench. As suggested by the latest tomographic images the subducting Juan de Fuca plate is segmented, with 'gaps' between the segments. These gaps may act as channels for the flow of mantle material.

  10. Tiffany Diamonds and Classical Music as Influences on the Performance of "Don Juan in Hell".

    ERIC Educational Resources Information Center

    Johnson, Jim

    This paper analyzes Paul Gregory's 1951 production of "Don Juan in Hell," now considered to be a seminal work in the development of professional and educational readers theatre. The paper contends that the production, which presented a nondramatic work without the usual emphasis on design and spectacle, forced a reexamination of the role…

  11. 78 FR 72060 - Chimney Rock National Monument Management Plan; San Juan National Forest; Colorado

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Chimney Rock National Monument Management Plan; San Juan National...) to establish management direction for the land and resources within Chimney Rock National Monument... establishing Chimney Rock National Monument (the Monument) requires preparation of a management plan. The...

  12. Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study.

    PubMed

    Brucato, A; Doria, A; Frassi, M; Castellino, G; Franceschini, F; Faden, D; Pisoni, M Pia; Solerte, L; Muscarà, M; Lojacono, A; Motta, M; Cavazzana, I; Ghirardello, A; Vescovi, F; Tombini, V; Cimaz, R; Gambari, P F; Meroni, P L; Canesi, B; Tincani, A

    2002-01-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus but are also considered a possible cause for unexplained pregnancy loss and adverse pregnancy outcome. In a large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic lupus erythematosus (SLE)) during their 122 pregnancies and 107 anti-Ro/SSA negative women (58 SLE) (140 pregnancies). Anti-Ro/SSA antibodies were tested by immunoblot and counterimunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of pregnancy loss (9.9 vs 18.6%), preterm birth (21.3 vs 13.9%), cesarean sections (49.2 vs 53.4%), premature rupture of membranes (4.9 vs 8.1%), preeclampsia (6.6 vs 8%), intrauterine growth retardation (0 vs 2.3%)and newborns small for gestational age (11.5 vs 5.8%) were similar in anti-Ro/SSA positive and negative SLE mothers; findings were similar in non-SLE women. Two cases of congenital heart block were observed out of 100 anti-Ro/SSA positive women. In conclusion, anti-Ro/SSA antibodies are responsible for congenital heart block but do not affect other pregnancy outcomes, both in SLE and in non-SLE women. The general outcome of these pregnancies is now very good, ifprospectively followed by multidisciplinary teams with ample experience in this field.

  13. Chronic ethanol administration increases the binding of sup 3 H Ro-15-4513 in primary cultured spinal cord neurons

    SciTech Connect

    Mlatre, M.; Ticku, M.K. )

    1989-02-09

    Ro 15-4513 (ethyl-8-azido-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo (1,5{alpha}), (1,4) benzodiazepine-3-carboxylate) is reported to be a selective ethanol antagonist in biochemical and behavioral studies. The effect of chronic ethanol treatment on the binding of ({sup 3}H)Ro 15-4513 was investigated in cultured spinal cord neurons, which are shown to possess all the elements of GABA benzodiazepine receptor complex. Chronic ethanol treatment (50 mM for 6 hr, 12 hr, 18 hr, 3 days, and 5{sub 3} days) produced an increase in the specific binding of ({sub 3}H)Ro 15-4513. The increase in binding in these neurons was due to an increase in the number (B{sub max}) of receptor sites. This effect was specific for Ro 15-4513, since identical ethanol treatment did not alter the binding of benzodiazepine antagonist ({sup 3}H)Ro 15-1788 or agonist ({sup 3}H)flunitrazepam or inverse agonist ({sup 3}H)methyl-{beta}-carboline-3-carboxylate. Similar results have been reported following chronic ethanol treatment to rats. These results suggest that the Ro 15-4513 binding sites on the oligomeric GABA receptor complex are altered following chronic ethanol administration, and support the notion of a unique role of Ro 15-4513 as an ethanol antagonist.

  14. Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L).

    PubMed

    Zhang, Jing; Fang, Lei; Zhu, Xuguo; Qiao, Yiting; Yu, Mei; Wang, Lu; Chen, Yuan; Yin, Wu; Hua, Zi-Chun

    2012-05-01

    Ro52/SSA is an autoantigen that presents in patients with SS (Sjögren's syndrome) and SLE (systemic lupus erythematosus). It increases cell death and redistributes itself to apoptotic blebs, but its pro-apoptotic function has not been completely identified. Overexpression of Ro52/SSA promoted cell apoptosis induced by DR (death receptor) in caspase-8-dependent manner. Ro52/SSA expression down-regulated c-FLIP(L) [cellular (Fas-associated death domain)-like interleukin 1β-converting enzyme-inhibitory protein long form] expression, and Ro52/SSA siRNAs (small interfering RNAs) increased c-FLIP(L) production, indicating that Ro52/SSA plays a role in c-FLIP(L) regulation. Ro52/SSA negatively regulated c-FLIP(L) transcriptional level probably by suppressing NF-κB (nuclear factor κB) signalling. The data suggest that Ro52/SSA is involved in DR-mediated apoptosis by regulating c-FLIP(L).

  15. Characterization of the Discriminative Stimulus Effects of a NOP Receptor Agonist Ro 64-6198 in Rhesus Monkeys

    PubMed Central

    Zelenock, Kathy A.; Lindsey, Angela M.; Sulima, Agnieszka; Rice, Kenner C.; Prinssen, Eric P.; Wichmann, Jürgen; Woods, James H.

    2016-01-01

    Nociceptin/orphanin FQ receptor (NOP) agonists have been reported to produce antinociceptive effects in rhesus monkeys with comparable efficacy to μ-opioid receptor (MOP) agonists, but without their limiting side effects. There are also known to be species differences between rodents and nonhuman primates (NHPs) in the behavioral effects of NOP agonists. The aims of this study were the following: 1) to determine if the NOP agonist Ro 64-6198 could be trained as a discriminative stimulus; 2) to evaluate its pharmacological selectivity as a discriminative stimulus; and 3) to establish the order of potency with which Ro 64-6198 produces discriminative stimulus effects compared with analgesic effects in NHPs. Two groups of rhesus monkeys were trained to discriminate either fentanyl or Ro 64-6198 from vehicle. Four monkeys were trained in the warm-water tail-withdrawal procedure to measure antinociception. Ro 64-6198 produced discriminative stimulus effects that were blocked by the NOP antagonist J-113397 and not by naltrexone. The discriminative stimulus effects of Ro 64-6198 partially generalized to diazepam, but not to fentanyl, SNC 80, ketocyclazocine, buprenorphine, phencyclidine, or chlorpromazine. Fentanyl produced stimulus effects that were blocked by naltrexone and not by J-113397, and Ro 64-6198 did not produce fentanyl-appropriate responding in fentanyl-trained animals. In measures of antinociception, fentanyl, but not Ro 64-6198, produced dose-dependent increases in tail-withdrawal latency. Together, these results demonstrate that Ro 64-6198 produced stimulus effects in monkeys that are distinct from other opioid receptor agonists, but may be somewhat similar to diazepam. In contrast to previous findings, Ro 64-6198 did not produce antinociception in the majority of animals tested even at doses considerably greater than those that produced discriminative stimulus effects. PMID:26801398

  16. Stratigraphic relationships of Cretaceous and early Tertiary rocks of a part of northwestern San Juan basin

    USGS Publications Warehouse

    Baltz, Elmer Harold

    1953-01-01

    The Bridge Timber Mountain area in south-central La Plata County, southwestern Colorado lies mostly in the northwestern part of the Central San Juan Basin but contains a segment of the bounding Hogback 'monocline' and Four-Corners platform. The area contains rocks of late Cretaceous through early Eocene age, as well as Pliocene, Pleistocene, and Recent terrace and pediment gravels. The Pictured Cliffs sandstone of late Montana age is the latest marine formation present. Retreat of the Cretaceous seas from the area marked the beginning of Laramide orogenic activity and the earliest stages of deformation which produced the modern San Juan Basin. The Fruitland formation and Kirtland shale were deposited in brackish water and on coastal plains left by the retreating Cretaceous sea. Beds of the Farmington sandstone member and upper shale member of the Kirtland shale show evidence of a new source of sediments to the north or northeast distinct from the southwestern source area of older Cretaceous rocks. The McDermott 'formation', composed mainly of volcanic debris, is considered to be a local lower member of the Animas formation. Beds of the upper member of the Animas formation of Cretaceous and Paleocene age are considered to extend entirely across the area and into New Mexico. Overstep of higher sandstone and shale beds of the upper member across lower conglomeratic beds shows that folding on the Hogback 'monocline' began during deposition of the upper member. Beds of the upper member of the Animas formation grade laterally southward into Paleocene beds of the Nacimiento formation, but upper Nacimiento beds overstep folded beds of the Animas formation on the Hogback 'monocline' at the north end of Bridge Timber Mountain. The San Jose formation of Paleocene and Eocene age is conformable with the Nacimiento formation except at the north end of Bridge Timber Mountain where upper San Jose beds overstep all older tilted beds down to the Fruitland formation. The heavy

  17. Limits to the presence of transiting circumbinary planets in CoRoT Data

    NASA Astrophysics Data System (ADS)

    Klagyivik, P.; Deeg, H. J.; Cabrera, J.; Csizmadia, Sz.; Almenara, J. M.

    2017-06-01

    Aims: During its flight phase, from 2007-2012, the CoRoT mission delivered light curves for over 2000 eclipsing binaries. Data from the Kepler mission have proven the existence of several transiting circumbinary planets. While light curves from CoRoT typically have lower precision and shorter coverage, the number of CoRoT targets is similar to that of Kepler and some of the known circumbinary planets could potentially be detected in CoRoT data as well. The aim of this work was to reanalyse the entire CoRoT Data set to search for the presence of circumbinary planets and to derive limits on the abundances of such planets. Methods: We developed a code that removes the signatures of eclipsing binaries from the light curves, and searches for quasi-periodic, transit-like features in the light curves after removal of binary eclipses and instrumental features. The code requires little information on sample systems and can also be used for other space missions, such as Kepler, K2, TESS, and PLATO. The code is broad in the requirements leading to detections, but was tuned to deliver an amount of detections that are manageable in a subsequent, mainly visual, assessment of their origin. Results: We identified three planet candidates in the CoRoT sample whose transits would have arisen from a single pass across the central binary; however, no candidates with transit events from multiple planetary orbits remained. We calculated the upper limits for the number of Jupiter, Saturn-, and Neptune-sized planets in co-planar orbits for different orbital period ranges. We found that there are much fewer giant planets in short periodic orbits around close binary systems than around single stars. Full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A117

  18. Improved variability classification of CoRoT targets with Giraffe spectra

    NASA Astrophysics Data System (ADS)

    Sarro, L. M.; Debosscher, J.; Neiner, C.; Bello-García, A.; González-Marcos, A.; Prendes-Gero, B.; Ordieres, J.; León, G.; Aerts, C.; de Batz, B.

    2013-02-01

    Aims: We present an improved method for automated stellar variability classification, using fundamental parameters derived from high resolution spectra, with the goal to improve the variability classification obtained using information derived from CoRoT light curves only. Although we focus on Giraffe spectra and CoRoT light curves in this work, the methods are much more widely applicable. Methods: In order to improve the variability classification obtained from the photometric time series, only rough estimates of the stellar physical parameters (Teff and log (g)) are needed because most variability types that overlap in the space of time series parameters, are well separated in the space of physical parameters (e.g. γ Dor/SPB or δ Sct/β Cep). In this work, several state-of-the-art machine learning techniques are combined to estimate these fundamental parameters from high resolution Giraffe spectra. Next, these parameters are used in a multi-stage Gaussian-Mixture classifier to perform an improved supervised variability classification of CoRoT light curves. The variability classifier can be used independently of the regression module that estimates the physical parameters, so that non-spectroscopic estimates derived e.g. from photometric colour indices can be used instead. Results: Teff and log (g) are derived from Giraffe spectra, for 6832 CoRoT targets. The use of those parameters in addition to information extracted from the CoRoT light curves, significantly improves the results of our previous automated stellar variability classification. Several new pulsating stars are identified with high confidence levels, including hot pulsators such as SPB and β Cep, and several γ Dor-δ Sct hybrids. From our samples of new γ Dor and δ Sct stars, we find strong indications that the instability domains for both types of pulsators are larger than previously thought. The CoRoT space mission, launched on 27 December 2006, has been developed and is operated by CNES, with

  19. New coupled-particle light-scattering assay for detection of Ro/SSA (52 and 60 kilodaltons) and La/SSB autoantibodies in connective tissue diseases.

    PubMed

    Bizzaro, N; Bonelli, F; Tonutti, E; Tozzoli, R; Villalta, D

    2001-09-01

    The diagnostic and analytical performance of the coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated. The antigens were obtained by recombinant DNA procedures to include the most immunogenic epitopes for each protein by using a prokaryotic expression system. Serum samples from 151 patients with connective tissue diseases and 52 control subjects (including patients with viral infections, patients with Lyme disease, and healthy subjects) were studied. Sensitivities for detection of anti-Ro/SSA and anti-La/SSB were 88.2 and 95.2%, respectively; specificities were 97.6 and 98.1%, respectively. The intra-assay coefficient of variation (CV) ranged from 4.3 to 10.9% for anti-Ro/SSA and from 2.8 to 12.5% for anti-La/SSB; interassay CVs ranged from 6.5 to 13.2% and from 8.2 to 14.5%, respectively. Among the anti-Ro/SSA-positive samples, Ro60 was recognized by 66% of the test sera and Ro52 was recognized by 95% of the test sera. Thirty-four percent of the Ro/SSA-positive sera were reactive only with the Ro52 antigen, indicating that anti-Ro52 is the most common antibody specificity recognized by anti-Ro/SSA autoantibodies. No differences were found between the prevalences of anti-Ro60 and anti-Ro52 in relation to systemic lupus erythematosus or Sjögren's syndrome. The results of the present study indicate that this new immunoassay is an efficient diagnostic tool for the detection of anti-Ro/SSA and anti-La/SSB antibodies in patients with autoimmune disorders.

  20. New Coupled-Particle Light-Scattering Assay for Detection of Ro/SSA (52 and 60 Kilodaltons) and La/SSB Autoantibodies in Connective Tissue Diseases

    PubMed Central

    Bizzaro, Nicola; Bonelli, Fabrizio; Tonutti, Elio; Tozzoli, Renato; Villalta, Danilo

    2001-01-01

    The diagnostic and analytical performance of the coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated. The antigens were obtained by recombinant DNA procedures to include the most immunogenic epitopes for each protein by using a prokaryotic expression system. Serum samples from 151 patients with connective tissue diseases and 52 control subjects (including patients with viral infections, patients with Lyme disease, and healthy subjects) were studied. Sensitivities for detection of anti-Ro/SSA and anti-La/SSB were 88.2 and 95.2%, respectively; specificities were 97.6 and 98.1%, respectively. The intra-assay coefficient of variation (CV) ranged from 4.3 to 10.9% for anti-Ro/SSA and from 2.8 to 12.5% for anti-La/SSB; interassay CVs ranged from 6.5 to 13.2% and from 8.2 to 14.5%, respectively. Among the anti-Ro/SSA-positive samples, Ro60 was recognized by 66% of the test sera and Ro52 was recognized by 95% of the test sera. Thirty-four percent of the Ro/SSA-positive sera were reactive only with the Ro52 antigen, indicating that anti-Ro52 is the most common antibody specificity recognized by anti-Ro/SSA autoantibodies. No differences were found between the prevalences of anti-Ro60 and anti-Ro52 in relation to systemic lupus erythematosus or Sjögren's syndrome. The results of the present study indicate that this new immunoassay is an efficient diagnostic tool for the detection of anti-Ro/SSA and anti-La/SSB antibodies in patients with autoimmune disorders. PMID:11527804

  1. Umbilical Cord Blood Levels of Maternal Antibodies Reactive with p200 and Full Length Ro52 in the Assessment of Risk for Cardiac Manifestations of Neonatal Lupus

    PubMed Central

    Reed, Joanne H.; Clancy, Robert M.; Lee, Kristen H.; Saxena, Amit; Izmirly, Peter M.; Buyon, Jill P.

    2012-01-01

    Objective Maternal anti-Ro autoantibodies associate with cardiac manifestations of neonatal lupus (cardiac NL), yet only 2% of women with this reactivity have an affected child. Identification of a more specific marker would channel intense monitoring to fetuses at greater risk. This study aims to determine whether autoantibodies against Ro52 amino acids 200–239 (p200) confer added risk over autoantibodies to full length Ro52, Ro60 or La. Methods/Results Anti-Ro-exposed pregnancies resulting in cardiac NL or no cardiac manifestations were identified from the Research Registry for Neonatal Lupus and PR Interval and Dexamethasone Evaluation. Umbilical cord (n=123) and maternal (n=115) samples were evaluated by ELISA. The frequencies of p200, Ro52, Ro60 and La autoantibodies were not significantly different between affected and unaffected children. However, neonatal anti-Ro52 and Ro60 titers were highest in cardiac NL and their unaffected siblings compared to unaffected neonates without a cardiac NL sibling. Although both maternal anti-Ro52 and p200 autoantibodies were less than 50% specific for cardiac NL, anti-p200 was the least likely of the Ro autoantibodies to be false positive in mothers who have never had an affected child. Titers of anti-Ro52 and p200 did not differ during a cardiac NL or unaffected pregnancy from the same mother. Conclusion Maternal reactivity to p200 does not confer an added risk to fetal conduction defects over full length Ro52 or Ro60 autoantibodies. Mothers who may never be at risk for having an affected child have lower anti-Ro60 titers and may require less stringent echocardiographic monitoring compared to women with high titer autoantibodies. PMID:22511615

  2. Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital

    SciTech Connect

    Hoffman, P.L.; Tabakoff, B.; Szabo, G.; Suzdak, P.D.; Paul, S.M.

    1987-08-03

    The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the incoordinating effect of ethanol in mice, as measured on an accelerating Rotarod. This effect was blocked by benzodiazepine receptor antagonists. In contrast, Ro15-4513 had no effect on ethanol-induced hypothermia in mice. However, Ro15-4513 reversed the hypothermic effect of pentobarbital, and, at higher dose, also reversed the incoordinating effect of pentobarbital in mice. The data support the hypothesis that certain of the pharmacological effects of ethanol are mediated by actions at the GABA-benzodiazepine receptor-coupled chloride channel. 35 references, 2 figures.

  3. PCR amplification of RoTat 1.2 VSG gene in Trypanosoma evansi isolates in Kenya.

    PubMed

    Ngaira, J M; Njagi, E N M; Ngeranwa, J J N; Olembo, N K

    2004-02-26

    A direct card agglutination test for Trypanosoma evansi, CATT/T. evansi based on the predominant variable antigen-type (pVAT) RoTat 1.2 was evaluated previously in the field in Isiolo District, Kenya. Sixteen out of 51 (31.4%) parasitologically positive camels were negative by the antibody detection test. In the present study, trypanosomes isolated from the camels were analysed in an attempt to determine the cause of the false negative results of CATT/T. evansi. A total of 20 field isolates comprised 16 stocks from camels that were negative by CATT/T. evansi, and 4 from CATT/T. evansi-positive camels. In addition, 15 known T. evansi and four T. brucei were used as reference. Purified DNA samples were tested using an established RoTat 1.2-based polymerase chain reaction (PCR) that yields a 488 bp product for the specific detection of T. evansi. Antibodies to RoTat 1.2 variant surface glycoprotein (VSG) were used in Western blotting to detect RoTat 1.2 VSG linear epitopes. Results of PCR and Western blot showed that the 16 stocks isolated from CATT/T. evansi-negative camels fell into three groups. In Group 1, both the RoTat 1.2 VSG gene and the VSG were absent in three stocks. In five trypanosome stocks in Group 2, the RoTat 1.2 VSG gene was detected, but Western blot was negative indicating absence of the expressed VSG. Five other stocks containing the RoTat 1.2 VSG gene were also in this group. The RoTat 1.2 VSG gene was detected and Western blot was positive in all four trypanosome stocks in Group 3. All four stocks from CATT/T. evansi-positive camels contained the RoTat 1.2 VSG gene and the expressed VSG. The reference T. evansi KETRI 2479 lacked the RoTat 1.2 VSG gene and there was no immune reactivity detected by Western blot. The rest of the reference T. evansi stocks examined contained the RoTat 1.2 VSG gene. All the four T. brucei samples examined were negative by PCR and Western blot. In conclusion, this study showed that the RoTat 1.2 VSG gene was absent

  4. Understanding nuclear motions in molecules: Derivation of Eckart frame ro-vibrational Hamiltonian operators via a gateway Hamiltonian operator

    SciTech Connect

    Szalay, Viktor

    2015-05-07

    A new ro-vibrational Hamiltonian operator, named gateway Hamiltonian operator, with exact kinetic energy term, T-hat, is presented. It is in the Eckart frame and it is of the same form as Watson’s normal coordinate Hamiltonian. However, the vibrational coordinates employed are not normal coordinates. The new Hamiltonian is shown to provide easy access to Eckart frame ro-vibrational Hamiltonians with exact T-hat given in terms of any desired set of vibrational coordinates. A general expression of the Eckart frame ro-vibrational Hamiltonian operator is given and some of its properties are discussed.

  5. BEER analysis of Kepler and CoRoT light curves. III. Spectroscopic confirmation of seventy new beaming binaries discovered in CoRoT light curves

    NASA Astrophysics Data System (ADS)

    Tal-Or, L.; Faigler, S.; Mazeh, T.

    2015-08-01

    Context. The BEER algorithm searches stellar light curves for the BEaming, Ellipsoidal, and Reflection photometric modulations that are caused by a short-period companion. These three effects are typically of very low amplitude and can mainly be detected in light curves from space-based photometers. Unlike eclipsing binaries, these effects are not limited to edge-on inclinations. Aims: Applying the algorithm to wide-field photometric surveys such as CoRoT and Kepler offers an opportunity to better understand the statistical properties of short-period binaries. It also widens the window for detecting intrinsically rare systems, such as short-period brown-dwarf and massive-planetary companions to main-sequence stars. Methods: Applying the search to the first five long-run center CoRoT fields, we identified 481 non-eclipsing candidates with periodic flux amplitudes of 0.5-87 mmag. Optimizing the Anglo-Australian-Telescope pointing coordinates and the AAOmega fiber-allocations with dedicated softwares, we acquired six spectra for 231 candidates and seven spectra for another 50 candidates in a seven-night campaign. Analysis of the red-arm AAOmega spectra, which covered the range of 8342-8842 Å, yielded a radial-velocity precision of ~1 km s-1. Spectra containing lines of more than one star were analyzed with the two-dimensional correlation algorithm TODCOR. Results: The measured radial velocities confirmed the binarity of seventy of the BEER candidates - 45 single-line binaries, 18 double-line binaries, and 7 diluted binaries. We show that red giants introduce a major source of false candidates and demonstrate a way to improve BEER's performance in extracting higher fidelity samples from future searches of CoRoT light curves. The periods of the confirmed binaries span a range of 0.3-10 days and show a rise in the number of binaries per ΔlogP toward longer periods. The estimated mass ratios of the double-line binaries and the mass ratios assigned to the single

  6. Arrachements des épines iliaques antéro-supérieures et antéro-inférieures chez l'adolescent sportifs: à propos de deux cas

    PubMed Central

    Louaste, Jamal; Cherrad, Taoufik; Rachid, Khalid

    2015-01-01

    Les arrachements des épines iliaques antéro-supérieures et antéro-inférieures sont des entités rares qui touchent surtout l'enfant et l'adolescent. Elles se voient généralement lors d'une activité sportive. Le tableau clinique est dominé par une douleur brutale et importante de la hanche de type mécanique. Alors que le diagnostic est confirmé par les examens radiologiques. Nous rapportons deux cas de fractures arrachement des épines iliaques l'une antéro-supérieure et l'autre antéro-inférieure. PMID:26985274

  7. Stellar parameters for stars of the CoRoT exoplanet field

    NASA Astrophysics Data System (ADS)

    Cortés, C.; Maciel, S. C.; Vieira, S.; Ferreira Lopes, C. E.; Leão, I. C.; de Oliveira, G. P.; Correia, C.; Canto Martins, B. L.; Catelan, M.; De Medeiros, J. R.

    2015-09-01

    Context. Spectroscopic observations represent a fundamental step in the physical characterization of stars and, in particular, in the precise location of stars in the HR diagram. Rotation is also a key parameter, impacting stellar properties and evolution, which modulates the interior and manifests itself on the surface of stars. To date, the lack of analysis based on large samples has prevented our understanding of the real impact of stellar parameters and rotation on the stellar evolution as well as on the behavior of surface abundances. The space missions, CoRoT and Kepler, are providing us with rotation periods for thousands of stars, thus enabling a robust assessment of the behavior of rotation for different populations and evolutionary stages. For these reasons, the follow-up programs are fundamental to increasing the returns of these space missions. An analysis that combines spectroscopic data and rotation/modulation periods obtained from these space missions provides the basis for establishing the evolutionary behavior of the angular momentum of solar-like stars at different evolutionary stages, and the relation of rotation with other relevant physical and chemical parameters. Aims: To support the computation and evolutionary interpretation of periods associated with the rotational modulation, oscillations, and variability of stars located in the CoRoT fields, we are conducting a spectroscopic survey for stars located in the fields already observed by the satellite. These observations allow us to compute physical and chemical parameters for our stellar sample. Methods: Using spectroscopic observations obtained with UVES/VLT and Hydra/Blanco, and based on standard analysis techniques, we computed physical and chemical parameters (Teff, log (g), [Fe/H], vmic, vrad, vsin (i), and A(Li)) for a large sample of CoRoT targets. Results: We provide physical and chemical parameters for a sample comprised of 138 CoRoT targets. Our analysis shows the stars in our

  8. Thematic trip: "Save Roşia MontanÄă"

    NASA Astrophysics Data System (ADS)

    Eugenia, Marcu

    2015-04-01

    The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

  9. Simple and reconfigured single-sideband OFDM RoF system.

    PubMed

    Xu, Yuming; Li, Xinying; Yu, Jianjun; Chang, Gee-Kung

    2016-10-03

    We propose a simple and reconfigured dispersion-tolerant single sideband (SSB) orthogonal frequency division multiplexing (OFDM) radio over fiber (RoF) system enabled by digital signal processing (DSP), one in-phase/quadrature (I/Q) modulator and direct-detection. The generated radio frequency (RF) is based on DSP and the frequency can be flexibly adjusted, which can be employed in the future software-defined radio access network (RAN). Based on our proposed system, we have experimentally demonstrated 16-ary quadrature amplitude modulation (16QAM) 21.87-Gb/s 21-GHz and 38-GHz SSB-OFDM RoF signal generation and transmission over 80-km single-mode fiber (SMF), respectively.

  10. Membrane autopsy based bio-fouling investigation of distillery spent wash RO treatment plant.

    PubMed

    Sharma, Pinki; Joshi, Himanshu

    2014-01-01

    In this paper, a thorough investigation has been done to evaluate the effects of different pollutants on membrane performance by autopsy. Autopsy was performed on fresh and fouled reverse osmosis (RO) membrane elements from a distillery spent wash treatment plant by different analyses, such as field emission scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy and X-ray diffraction, to identify the cause of poor performance of an RO plant. Results obtained from the analysis of membranes indicate that a mixture of colloids and organic matters (polysaccharides and amines) along with the presence of multivalent ions (Ca, Mg, Fe and SO4) causes membrane fouling, which in turn affects membrane performance. Possible measures to improve treated effluent quality and mitigate fouling have been suggested for this particular case study.

  11. Side band suppression for wide band optical RoF systems

    NASA Astrophysics Data System (ADS)

    Abir, Hraghi; Ben Abid, Samir; Menif, Mourad

    2015-05-01

    In this paper, we propose a flexible monocycle generator that is based on multi-tonal excitation of a dual-arm MZM. The proposed generator permits the generation of different waveforms, such as Gaussian, first order Gaussian derivative, sinusoidal, cosine and sinc pulses. We exploit the proposed generator in order to generate the International Telecommunication Union-Radiocommunication( ITU-R) recommended channelization which contains four carrier frequencies, spaced by 2.16 GHz (58.32 GHz, 60.48 GHz, 62.64 GHz and 64.80 GHz). This millimeter waves (mmwaves) have attracted a great deal of attention in the Radio over Fiber (RoF) systems. The main challenge of the RoF system is to provide higher bands and increase significantly data rate with using millimeter-wave (mm-wave) band.

  12. Magnetic order on a frustrated lattice due to orbital degrees of freedom in RO2 hyperoxides

    NASA Astrophysics Data System (ADS)

    Oleś, Andrzej M.; Wohlfeld, Krzysztof; Daghofer, Maria

    2012-02-01

    The alkali RO2 hyperoxides (R=Rb,Cs,K) crystallize in a frustrated bct lattice. Nevertheless, all of the members of the family of alkali RO2 hyperoxides have long range layered C-type antiferromagnetic (C-AF) order at low temperature. We show that including the almost degenerate p-orbital degrees of freedom in a realistic spin-orbital model can resolve this contradiction [1]. Although a priori the orbital degrees of freedom do not remove frustration in spin system, we show that the anomalously large interorbital hopping together with the orbital order induced by the lattice stabilize the C-AF order in this class of compounds, in agreement with generalized Goodenough-Kanamori rules formulated here. [4pt] [1] K. Wohlfeld, M. Daghofer, and A.M. Ole's, EPL 96, 27001 (2011).

  13. [Oral treatment of severe psoriasis with a new aromatic retinoid (Ro 10-9359) (author's transl)].

    PubMed

    Guilhou, J J; Malbos, S; Meynadier, J

    1978-10-01

    The aromatic retinoic acid derivative Ro 10-9359 was administered orally to 25 severe psoriatic patients (14 with generalized plaques, 7 erythrodermic, 4 pustular). The initial dose was 25 mg/20 kg body weight daily for 4 weeks; afterwards the same posology was given every other day during several months (Max : 18 months). Excellent results were obtained in 16 patients (64 p. 100) particularly in severe erythrodermic and pustular psoriasis. However, under follow-up therapy relapses sometimes occurred leading to temporary resumption of initial posology. The most important side effects are cheilitis, palmoplantar scaling with thinning of the skin, hyperhidrosis and diffuse hair loss. A slight increase of transaminases and of alkaline phosphatases was found in a few patients. The Ro 10-9359 compound is a very useful new therapy of severe psoriasis.

  14. Aspects of the Eckart frame ro-vibrational kinetic energy operator.

    PubMed

    Szalay, Viktor

    2015-08-14

    A most decisive part of developing the Eckart frame ro-vibrational kinetic energy operator (KEO) in terms of curvilinear internal coordinates is the introduction of vibrational displacements obeying the Eckart conditions. It is examined here, how such displacements may be constructed by orthogonal and nonorthogonal transformations, and how they can be employed in developing the KEO. In particular, it is shown analytically, by term by term comparison, that the Eckart KEOs obtained by employing Pickett's method and the gateway Hamiltonian method are equivalent. That is, although it may appear in the form of very different expressions, the general, exact ro-vibrational Eckart frame KEO is unique. As side result, it has been shown that the simple formula of the pseudo-potential derived by Watson for the exact KEO given in normal coordinates applies to any Eckart frame KEO, irrespective of the choice of the vibrational coordinates.

  15. ASTRO APEx(®) and RO-ILS™ are applicable to medical malpractice in radiation oncology.

    PubMed

    Zaorsky, Nicholas G; Ricco, Anthony G; Churilla, Thomas M; Horwitz, Eric M; Den, Robert B

    2016-11-01

    To analyze malpractice trials in radiation oncology and assess how ASTRO APEx(®) and RO-ILS™ apply to such cases. The Westlaw database was reviewed using PICOS/PRISMA methods. Fisher's exact and Mann-Whitney U tests were used to find factors associated with outcomes. Of 34 cases identified, external beam was used in 26 (77%). The most common factors behind malpractice were excessive toxicity (80%) and lack of informed consent (66%). ASTRO APEx pillars and ROI-LS had applicability to all but one case. Factors favoring the defendant included statute of limitations (odds ratio: 8.1; 95% CI: 1.3-50); those favoring the plaintiff included patient death (odds ratio: 0.7; 95% CI: 0.54-0.94). APEx and RO-ILS are applicable to malpractice trials in radiation oncology.

  16. Aspects of the Eckart frame ro-vibrational kinetic energy operator

    NASA Astrophysics Data System (ADS)

    Szalay, Viktor

    2015-08-01

    A most decisive part of developing the Eckart frame ro-vibrational kinetic energy operator (KEO) in terms of curvilinear internal coordinates is the introduction of vibrational displacements obeying the Eckart conditions. It is examined here, how such displacements may be constructed by orthogonal and nonorthogonal transformations, and how they can be employed in developing the KEO. In particular, it is shown analytically, by term by term comparison, that the Eckart KEOs obtained by employing Pickett's method and the gateway Hamiltonian method are equivalent. That is, although it may appear in the form of very different expressions, the general, exact ro-vibrational Eckart frame KEO is unique. As side result, it has been shown that the simple formula of the pseudo-potential derived by Watson for the exact KEO given in normal coordinates applies to any Eckart frame KEO, irrespective of the choice of the vibrational coordinates.

  17. Antiscalant removal in accelerated desupersaturation of RO concentrate via chemically-enhanced seeded precipitation (CESP).

    PubMed

    McCool, Brian C; Rahardianto, Anditya; Cohen, Yoram

    2012-09-01

    An experimental study was carried out to demonstrate and quantify the feasibility of antiscalant (AS) removal from brackish water RO concentrate of high gypsum scaling propensity via lime treatment prior to seeded gypsum precipitation. Based on studies with model solutions, it was shown that sufficient AS removal (up to ∼90%) from RO concentrate is feasible via a lime treatment step (at a dose significantly lower than that required for conventional lime softening) to enable effective subsequent seeded gypsum precipitation. This two-step chemically-enhanced seeded precipitation (CESP) treatment of primary RO concentrate is suitable as an intermediate concentrate demineralization (ICD) stage for high recovery desalting employing secondary RO desalination. Analysis of gypsum precipitation and lime treatment kinetic data suggests that, after adequate CaCO(3) precipitation has been induced for effective AS scavenging, CaSO(4) desupersaturation can be achieved via seeded gypsum precipitation without retardation due to seed poisoning by AS. Also, the lime dose required to prevent seed poisoning during subsequent gypsum desupersaturation via seeded gypsum precipitation can be adequately assessed with a precipitation kinetics model that considers AS seed poisoning based on a Langmuir adsorption isotherm. The degree of AS removal after lime treatment increased linearly with the logarithm of the single lime dose additions. Staged lime dosing (i.e., multiple lime additions), however, removed a higher degree of AS relative to an equivalent single lime dose addition since a higher driving force for CaCO(3) precipitation could be maintained over the course of the lime treatment period.

  18. CoRoT observations of the young open cluster Dolidze 25

    NASA Astrophysics Data System (ADS)

    Ripepi, V.; Leccia, S.; Baglin, A.; Ruoppo, A.; Bernabei, S.; Zwintz, K.; Cusano, F.; Gandolfi, D.; Guenter, E. W.; Alencar, S.; Marconi, M.; Monteiro, M. J. P. F. G.; Palla, F.; Alcalá, J. M.; Boehm, T.; Catala, C.; Chavero, C.; Corradi, W. S.; Degl'Innocenti, S.; de La Reza, R.; Deluil, M.; Favata, F.; Fernandez, M.; Gregorio-Hetem, J.; Lepine, J. D. R.; Pinheiro, F. J. G.; Prada Moroni, P. G.; Quast, G.; Torres, C. A. O.; Weiss, W.

    2010-07-01

    We present some preliminary results based on the CoRoT observations of the young distant cluster Dolidze 25. The light curve for the 28 stars observed by the satellite have been analyzed and the relevant periodogram presented. As a result we have found two binary, three Pulsating Be, three SPB, two Spotted and one ellipsoidal variables. Noteworthy, we have also identified one PMS δ Scuti candidate.

  19. Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

    SciTech Connect

    Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.

    1989-04-01

    The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone.

  20. Learning to Improve E-mail Classification with numéro interactive

    NASA Astrophysics Data System (ADS)

    Jones, Dean M.

    This paper describes some of the ways in which we use artificial intelligence technologies in numéro interactive, a Customer Interaction Management system. In particular, we focus on the classification of e-mail messages into one of multiple business categories. We describe different features that are extracted from e-mail messages to help in this classification, and the improvement in the overall classification accuracy that results from the use of each kind of feature.

  1. Growth conditions, compact perturbations and operator subdecomposability, with applications to generalized Cesàro operators

    NASA Astrophysics Data System (ADS)

    Miller, T. L.; Miller, V. G.; Neumann, M. M.

    2005-01-01

    We adapt recent results of Albrecht and Ricker to obtain conditions under which growth constraints on the left resolvent of a Banach space operator are preserved under suitable perturbations. As an application, we establish Bishop's property ([beta]) for certain generalized Cesàro operators on the classical Hardy spaces Hp, 1

  2. Detection of new pulsations in the roAp star HD 177765

    NASA Astrophysics Data System (ADS)

    Holdsworth, Daniel L.

    2016-10-01

    We report the discovery of 2 previously undetected pulsation frequencies in the known roAp star HD 177765. Photometric observations by the Kepler space telescope during K2 Campaign 7 show low-amplitude pulsations (4-11 micro mag) previously unseen in photometry. We show the pulsations to be stable over the observation period, and demonstrate that the separation of the frequencies is not representative of the large frequency separation quantity needed to perform asteroseismic analysis.

  3. Raman investigation of ro-vibrational modes of interstitial H2 in Si

    NASA Astrophysics Data System (ADS)

    Koch, S. G.; Lavrov, E. V.; Weber, J.

    2012-08-01

    A Raman scattering study of ro-vibrational transitions Q(J) of the interstitial H2 in Si is presented. It is shown that the Q(2) mode of para hydrogen is coupled to the TAX phonon of Si. The mode appears in the spectra at temperatures above 200 K. The results presented also suggest that the Q(3) transition of ortho hydrogen is resonantly coupled to the OΓ phonon.

  4. Benzodiazepine receptor binding in vivo with (/sup 3/)-Ro 15-1788

    SciTech Connect

    Goeders, N.E.; Kuhar, M.J.

    1985-07-29

    In vivo benzodiazepine receptor binding has generally been studied by ex vivo techniques. In this investigation, the authors identify the conditions where (/sup 3/H)-Ro 15-1788 labels benzodiazepine receptors by true in vivo binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. (/sup 3/H)-Flunitrazepam and (/sup 3/H)-clonazepam did not exhibit useful in vivo receptor binding. 39 references, 5 figures, 1 table.

  5. THE FUTURE OF THE SUN: AN EVOLVED SOLAR TWIN REVEALED BY CoRoT

    SciTech Connect

    Do Nascimento, J.-D. Jr.; Da Costa, J. S.; Castro, M.; Takeda, Y.; Melendez, J.

    2013-07-10

    The question of whether the Sun is peculiar within the class of solar-type stars has been the subject of active investigation over the past three decades. Although several solar twins have been found with stellar parameters similar to those of the Sun (albeit in a range of Li abundances and with somewhat different compositions), their rotation periods are unknown, except for 18 Sco, which is younger than the Sun and with a rotation period shorter than solar. It is difficult to obtain rotation periods for stars of solar age from ground-based observations, as a low-activity level implies a shallow rotational modulation of their light curves. CoRoT has provided space-based long time series from which the rotation periods of solar twins as old as the Sun could be estimated. Based on high-signal-to-noise, high-resolution spectroscopic observations gathered at the Subaru Telescope, we show that the star CoRoT ID 102684698 is a somewhat evolved solar twin with a low Li abundance. Its rotation period is 29 {+-} 5 days, compatible with its age (6.7 Gyr) and low lithium content, A{sub Li} {approx}< 0.85 dex. Interestingly, our CoRoT solar twin seems to have enhanced abundances of the refractory elements with respect to the Sun, a typical characteristic of most nearby twins. With a magnitude V {approx_equal} 14.1, ID 102684698 is the first solar twin revealed by CoRoT, the farthest field solar twin so far known, and the only solar twin older than the Sun for which a rotation period has been determined.

  6. The acoustic cut-off frequency of roAp stars

    NASA Astrophysics Data System (ADS)

    Audard, N.; Kupka, F.; Morel, P.; Provost, J.; Weiss, W. W.

    1998-07-01

    Some of the rapidly oscillating (roAp) stars, have frequencies which are larger than the acoustic cut-off frequency determined from published stellar models which usually assume a grey atmosphere. As the cut-off frequency depends on the T(tau ) relation, we have computed models and adiabatic frequencies for pulsating Ap stars with more realistic atmospheres which include a frequency dependent treatment of radiative transfer, take blanketing effects into account, and which have a better treatment of the radiative pressure. In addition, we are using opacity distribution functions specific to the atmospheric composition. With these improvements over the classical stellar models the theoretical acoustic cut-off frequency for roAp stars are increased by about 200 mu Hz, which brings them close to the observations. We restrict the comparison of our computations with observations to those two `pathological' roAp stars for which more reliable astrophysical parameters are available, HD 24712 and alpha Cir, and comment briefly on a third one, HD 134214. For alpha Cir we find models which have indeed a cut-off frequency beyond the largest observed frequency and which are well within the Teff - L/L_⊙ error box. For HD 24712 only models which are hotter by about 100 K and less luminous by nearly 10% than what is actually the most probable value derived by spectroscopy would have an acoustic cut-off frequency large enough. HD 134214 fits our models best, however, the error box for Teff - L/L_⊙ is the largest of all three stars. One may thus speculate that the old controversy about a mismatch between observed largest frequencies and theoretical cut-off frequencies of roAp star models is resolved. Based on hipparcos data.

  7. VizieR Online Data Catalog: CoRoT 105906206 frequencies analysis (da Silva+, 2014)

    NASA Astrophysics Data System (ADS)

    da Silva, R.; Maceroni, C.; Gandolfi, D.; Lehmann, H.; Hatzes, A. P.

    2014-03-01

    The file frequenc.dat contains the table with 220 frequencies, amplitudes, and phases, together with their uncertainties, derived for the light curve of CoRoT 105906206 with pulsations only (after subtracting the best binary model). The uncertainties are the formal values computed using equations (4), (10), and (11) of Montgomery & O'Donoghue (1999DSSN...13...28M). (1 data file).

  8. The experiences of pregnancy in women with SSA/Ro52 autoantibodies.

    PubMed

    Tingström, Joanna; Barimani, Mia; Sonesson, Sven-Erik; Wahren-Herlenius, Marie; Henriksson, Elisabet Welin

    2010-12-01

     Congenital heart block may develop in the foetus during pregnancy in SSA/Ro52 autoantibody-positive women. The aim of this study was to investigate how women with SSA/Ro52 autoantibodies experience their pregnancy in terms of the risk of developing foetal heart block, and in undergoing serial ultrasound Doppler echocardiography to detect early signs of congenital heart block.  Data were collected through individual semi-structured interviews with SSA/Ro52-positive women post-pregnancy (n = 14). The interviews were audio-taped, transcribed verbatim and analysed according to qualitative content analysis.  Three categories emerged from the responses: information, emotional response and support. The information received prior to and during early pregnancy was focused on the need for attending a specialized antenatal clinic, and information on the risk for congenital heart block was scarce or missing. During gestational weeks 18-24, when the ultrasound/Doppler examinations were performed, all women described increased stress. However, the interaction with the caregivers made the women feel more safe and secure. Several women also said that they did not emotionally acknowledge the pregnancy until after gestational week 24. None had been offered psychological support.  There is a need for structured information and organized programmes for the surveillance of women who are SSA/Ro52 positive during their pregnancy. Further, offering psychological support to the women and their families to manage the stress and to facilitate the early attachment to the child should be considered. Copyright © 2010 John Wiley & Sons, Ltd.

  9. Exploring the Helium Core of the δ Scuti Star CoRoT 102749568 with Asteroseismology

    NASA Astrophysics Data System (ADS)

    Chen, Xinghao; Li, Yan; Lin, Guifang; Chen, Yanhui; Guo, Junjun

    2017-01-01

    Based on regularities in rotational splitting, we seek possible multiplets for the observed frequencies of CoRoT 102749568. There are 21 sets of multiplets identified, including four sets of multiplets with l = 1, nine sets of multiplets with l = 2, and eight sets of multiplets with l = 3. In particular, there are three complete triplets (f10, f12, f14), (f31, f34, f35), and (f41, f43, f44). The rotational period of CoRoT 102749568 is estimated to be {1.34}-0.05+0.04 days. When doing model fittings, three l = 1 modes (f12, f34, and f43) and the radial first overtone f13 are used. Our results shows that the three nonradial modes (f12, f34, and f43) are mixed modes, which mainly provide constraints on the helium core. The radial first overtone f13 mainly provides constraint on the stellar envelope. Hence the size of the helium core of CoRoT 102749568 is determined to be {M}{He} = 0.148 ± 0.003 M⊙ and {R}{He} = 0.0581 ± 0.0007 R⊙. The fundamental parameters of CoRoT 102749568 are determined to be M = 1.54 ± 0.03 M⊙, Z=0.006, {f}{ov}=0.004+/- 0.002, {log} g=3.696+/- 0.003, {T}{eff}=6886+/- 70 K, R = 2.916 ± 0.039 R⊙, and L = 17.12 ± 1.13 L⊙.

  10. Threshold scaling limits of RO concentrates flowing in a long waste disposal pipeline.

    PubMed

    Semiat, R; Hasson, D; Zelmanov, G; Hemo, I

    2004-01-01

    Disposal of RO concentrates emanating from inland brackish water desalination plants presents a difficult environmental problem. The solution adopted by Mekorot--the National Water Company of Israel--is to construct a 30 km waste disposal pipeline for collecting concentrates emanating from several RO desalination plants and discharging them into the sea. The discharged concentrates are highly supersaturated with respect to CaCO3. Scale precipitation during concentrate flow through the RO module is inhibited by the presence of anti-scalants. The retention time of the concentrate solution in the discharge pipe will exceed 100 hours. This raises the issue of the risk of scale precipitation in the discharge pipe that could impair its proper functioning. The aim of the present study was to provide data for guiding the design and operation of the disposal pipeline. The extent of the induction period prior to the onset of precipitation was measured in a pilot plant simulating flow of concentrate solutions dosed with anti-scalants. The parameters investigated were the scaling potential, the anti-scalant concentration and the presence of a mixture of several anti-scalants. The results of this study provide threshold scaling limits under various conditions.

  11. Foam-Mat Freeze-Drying of Bifidobacterium longum RO175: Viability and Refrigerated Storage Stability.

    PubMed

    Izquierdo-López, Danilo; Goulet, Jacques; Ratti, Cristina

    2017-01-01

    Foaming as a pretreatment was used prior to freeze-drying of Bifidobacterium longum RO175 to investigate the potential acceleration of the drying rate and increase in microorganism viability after the process. A study on storage of foamed and nonfoamed freeze-dried products at 4 °C completed this study. B. longum RO175 in foamed medium could be freeze-dried in 1/7 to 1/4 of the time required for nonfoamed suspensions. In addition, foamed suspensions presented higher viability immediately after freeze-drying (13.6% compared to 12.81 % or 11.46%, depending on the cryoprotective media). Refrigerated storage led to a reduction in B. longum RO175 viability for all tested protective agents (foamed and nonfoamed). No correlation between glass transition temperature and stability of probiotic powders was observed during storage. In addition, lower viability after 56 d of storage was observed for foamed materials, probably due to foam porous structure and higher hygroscopicity, and oxygen presence and moisture pickup during storage. © 2016 Institute of Food Technologists®.

  12. Quantum scattering calculations for ro-vibrational de-excitation of CO by hydrogen atoms

    NASA Astrophysics Data System (ADS)

    Song, Lei; Balakrishnan, N.; van der Avoird, Ad; Karman, Tijs; Groenenboom, Gerrit C.

    2015-05-01

    We present quantum-mechanical scattering calculations for ro-vibrational relaxation of carbon monoxide (CO) in collision with hydrogen atoms. Collisional cross sections of CO ro-vibrational transitions from v = 1, j = 0 - 30 to v' = 0, j' are calculated using the close coupling method for collision energies between 0.1 and 15 000 cm-1 based on the three-dimensional potential energy surface of Song et al. [J. Phys. Chem. A 117, 7571 (2013)]. Cross sections of transitions from v = 1, j ≥ 3 to v' = 0, j' are reported for the first time at this level of theory. Also calculations by the more approximate coupled states and infinite order sudden (IOS) methods are performed in order to test the applicability of these methods to H-CO ro-vibrational inelastic scattering. Vibrational de-excitation rate coefficients of CO (v = 1) are presented for the temperature range from 100 K to 3000 K and are compared with the available experimental and theoretical data. All of these results and additional rate coefficients reported in a forthcoming paper are important for including the effects of H-CO collisions in astrophysical models.

  13. [Demographic profile of Boróro Indians from Mato Grosso State, Brazil, 1993-1996].

    PubMed

    Souza, Luciene Guimarães de; Pagliaro, Heloisa; Santos, Ricardo Ventura

    2009-02-01

    This paper analyzes the demographic profile of the Boróro Indians from Mato Grosso State, Brazil, from 1993 to 1996. Data came from annual collection and registration of vital statistics conducted by the health service in three villages (Garças, Meruri, and Morada dos Boróro). The average annual population growth rate was 2.4%. Nearly half (44%) of the population was younger than 15 years (median 16 years). The crude birth rate was 30.9 per 1,000 and the crude death rate 7.3 per 1,000 inhabitants. The infant mortality rate was high (58.8 per thousand live births), probably resulting from precarious health conditions in the villages. The results showed that women married younger than men and that there were numerous unmarried adult men (26.7%) and women (13.3%), as compared to data from other indigenous groups. The total fertility rate of Boróro women was 4.3, quite low compared to other indigenous communities in Brazil. The study emphasizes the importance of systematically collecting and analyzing demographic data on indigenous populations.

  14. Ro-vibrational excitation, alignment and orientation distributions of fast non-dissociatively scattered molecules

    NASA Astrophysics Data System (ADS)

    Harder, R.; Snowdon, K. J.

    1997-12-01

    The ro-vibrational distribution of fast diatomic molecules scattered from an uncorrugated surface under strongly dissipative glancing incidence conditions is calculated. The classical trajectory simulation includes potential surface switching associated with hot-electron scattering processes. Both ro-vibrational excitation and strong alignment of the classical angular momentum vector in the surface plane ("cartwheel motion") are observed, independent of the occurrence of potential surface switching. Ro-vibrational excitation is enhanced strongly by transitions between potential surfaces. The resultant larger proportion of molecules in highly rotationally excited states leads to a higher fraction of cartwheel-aligned molecules in the scattered molecule ensemble. The molecules which dissociate in the simulation are characterised by surface normal peaked internuclear axis orientation distributions. This is in agreement with the results of recent experiments [A. Nesbitt et al., Surf. Sci. 331-333 (1995) 321]. We observe, in addition, an enhanced rotational population of "topspin" oriented molecules, which arises from differences in the surface parallel oriented friction forces acting on each atom of the molecule. Glancing incidence scattering from well-prepared close-packed metal surfaces would appear to provide an efficient, general method to obtain a beam of preferentially aligned fast neutral diatomic molecules.

  15. Influence of surface properties of RO membrane on membrane fouling for treating textile secondary effluent.

    PubMed

    Yin, Zhonglong; Yang, Cheng; Long, Chao; Li, Aimin

    2017-07-01

    Reverse osmosis (RO) is a promising technology for treating and reusing textile secondary effluent (SE). To better understand the effect of membrane surface properties on membrane fouling, the performances of three commercial polyamide thin-film composite RO membranes (BW30-4040, CPA2-4040, and RE-4040-FEN) with different roughness and hydrophilicity were investigated for treating textile SE. The RO membranes were characterized by ATR-FTIR, SEM, AFM, and contact angle, respectively. The results showed that the flux increased with an increase in the surface hydrophilicity of membrane. CPA2-4040 had the highest hydrophilic surface and thus the largest initial flux. There was a strong correlation between the membrane fouling and the surface roughness; the fouling increased with an increase in the surface roughness. The roughest surface of CPA2-4040 led to the most significantly flux decline. However, the fouling reversibility was not related directly to surface roughness. BW30-4040 with the secondary roughness and the most hydrophobic surface had the highest fouling reversibility. This was mainly due to the primary hydrophilicity of textile SE in nature. Fluorescence excitation-emission matrix (EEM) showed that hydrophilic neutral protein-like matters and soluble microbial products (SMP) were the main foulants, thus stronger affinity with hydrophilic surface of membrane. Graphical abstract ᅟ.

  16. Tropical temperature variability and Kelvin-wave activity in the UTLS from GPS RO measurements

    NASA Astrophysics Data System (ADS)

    Scherllin-Pirscher, Barbara; Randel, William J.; Kim, Joowan

    2017-01-01

    Tropical temperature variability over 10-30 km and associated Kelvin-wave activity are investigated using GPS radio occultation (RO) data from January 2002 to December 2014. RO data are a powerful tool for quantifying tropical temperature oscillations with short vertical wavelengths due to their high vertical resolution and high accuracy and precision. Gridded temperatures from GPS RO show the strongest variability in the tropical tropopause region (on average 3 K2). Large-scale zonal variability is dominated by transient sub-seasonal waves (2 K2), and about half of sub-seasonal variance is explained by eastward-traveling Kelvin waves with periods of 4 to 30 days (1 K2). Quasi-stationary waves associated with the annual cycle and interannual variability contribute about a third (1 K2) to total resolved zonal variance. Sub-seasonal waves, including Kelvin waves, are highly transient in time. Above 20 km, Kelvin waves are strongly modulated by the quasi-biennial oscillation (QBO) in stratospheric zonal winds, with enhanced wave activity during the westerly shear phase of the QBO. In the tropical tropopause region, however, peaks of Kelvin-wave activity are irregularly distributed in time. Several peaks coincide with maxima of zonal variance in tropospheric deep convection, but other episodes are not evidently related. Further investigations of convective forcing and atmospheric background conditions are needed to better understand variability near the tropopause.

  17. Removal of bisphenol A (BPA) from water by various nanofiltration (NF) and reverse osmosis (RO) membranes.

    PubMed

    Yüksel, Suna; Kabay, Nalan; Yüksel, Mithat

    2013-12-15

    The removal of an endocrine disrupting compound, bisphenol A (BPA), from model solutions by selected nanofiltration (NF) and reverse osmosis (RO) membranes was studied. The commercially available membranes NF 90, NF 270, XLE BWRO, BW 30 (Dow FilmTech), CE BWRO and AD SWRO (GE Osmonics) were used to compare their performances for BPA removal. The water permeability coefficients, rejection of BPA and permeate flux values were calculated for all membranes used. No significant changes in their BPA removal were observed for all tight polyamide based NF and RO membranes tested except for loose NF 270 membrane. The polyamide based membranes exhibited much better performance than cellulose acetate membrane for BPA removal. Almost a complete rejection (≥ 98%) for BPA was obtained with three polyamide based RO membranes (BW 30, XLE BWRO and AD SWRO). But cellulose acetate based CE BWRO membrane offered a low and variable (10-40%) rejection for BPA. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. On Cesàro Limit Distribution of a Class of Permutative Cellular Automata

    NASA Astrophysics Data System (ADS)

    Maass, Alejandro; Martinez, Servet

    1998-01-01

    We study Cesàro means (time averages) of the evolution measures of the class of permutative cellular automata over {0, 1}ℕ defined by (\\varphi _B x)_n = x_{n{kern 1pt} {kern 1pt} + {kern 1pt} {kern 1pt} R} + Pi _{j{kern 1pt} {kern 1pt} = {kern 1pt} {kern 1pt} 0}^{R{kern 1pt} {kern 1pt} - {kern 1pt} {kern 1pt} 1} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} {kern 1pt} (1 + b_j + x_{n{kern 1pt} {kern 1pt} + {kern 1pt} {kern 1pt} j} ) where B= b 0 ⋯ b R-1is an aperiodic block in {0, 1} R and operations are taken mod 2. If the initial measure is Bernoulli, we prove that the limit of the Cesàro mean of the first column distribution exists. When R = 1 and B = 1, φ B is the mod 2 sum automaton. For this automaton we show that the limit is the (1/2, 1/2(-Bernoulli measure, and if the initial measure is Markov, we show that the limit of Cesàro mean of the one-site distribution is equidistributed.

  19. Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR-RO.

    PubMed

    Dolar, Davor; Gros, Meritxell; Rodriguez-Mozaz, Sara; Moreno, Jordi; Comas, Joaquim; Rodriguez-Roda, Ignasi; Barceló, Damià

    2012-11-15

    The presence of emerging contaminants in the aquatic environment and their potential effects on living organisms has become an issue of growing concern. Among emerging contaminants, pharmaceuticals may enter the aquatic environment due to their high consumption and their incomplete removal in conventional municipal wastewater treatment plants (WWTPs). The main goal of this study was the assessment of the removal efficiency of pharmaceuticals found in municipal wastewater of a coastal WWTP (Castell-Platja d'Aro, Spain) using an integrated pilot scale membrane system (MBR-RO). Twenty multiple-class pharmaceuticals (including psychiatric drugs, macrolide antibiotics, β-blockers, sulfonamide and fluoroquinolone antibiotics, histamine H2 receptor antagonists, anti-inflammatories, nitroimidazole, β-agonist and antiplatelet agent) were measured in real influent with the lowest average concentration for psychiatric drugs (0.017 μg L(-1)) to the highest for macrolide antibiotics (2.02 μg L(-1)). Although some contaminants were in relatively high concentrations (even up to 2.90 μg L(-1) in the case of ofloxacin). The combination of MBR and RO treatment showed excellent overall removal of target emerging contaminants with removal rates above 99% for all of them. For some compounds (metronidazole, hydrocodone, codein, ranitidine) MBR provided high removal efficiency (up to 95%). Additionally RO membrane showed removal rates always higher than 99%.

  20. THE CoRoT DISCOVERY OF A UNIQUE TRIPLE-MODE CEPHEID IN THE GALAXY

    SciTech Connect

    Poretti, E.; Baglin, A.; Weiss, W. W.

    2014-11-10

    The exploitation of the CoRoT treasure of stars observed in the exoplanetary field allowed the detection of a unusual triple-mode Cepheid in the Milky Way, CoRoT 0223989566. The two modes with the largest amplitudes and a period ratio of 0.80 are identified with the first (P {sub 1} = 1.29 days) and second (P {sub 2} = 1.03 days) radial overtones. The third period, which has the smallest amplitude but is able to produce combination terms with the other two, is the longest one (P {sub 3} = 1.89 days). The ratio of 0.68 between the first-overtone period and the third period is the unusual feature. Its identification with the fundamental radial or a nonradial mode is discussed with respect to similar cases in the Magellanic Clouds. In both cases, the period triplet and the respective ratios make the star unique in our Galaxy. The distance derived from the period-luminosity relation and the galactic coordinates put CoRoT 0223989566 in the metal-rich environment of the ''outer arm'' of the Milky Way.

  1. RoCoMAR: Robots' Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

    PubMed Central

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2013-01-01

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay. PMID:23881134

  2. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    NASA Astrophysics Data System (ADS)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  3. Pregnancy Outcomes in Patients with Autoimmune Diseases and Anti-Ro/SSA Antibodies

    PubMed Central

    Cimaz, Rolando; Caporali, Roberto; Ramoni, Véronique; Buyon, Jill

    2013-01-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB), neonatal transient skin rash, hematological and hepatic abnormalities), but do not negatively affects other gestational outcomes, and the general outcome of these pregnancies is now good, when followed by experienced multidisciplinary teams. The prevalence of CHB, defined as an atrioventricular block diagnosed in utero, at birth, or within the neonatal period (0–27 days after birth), in the offspring of an anti-Ro/SSA-positive women is 1–2%, of neonatal lupus rash around 10–20%, while laboratory abnormalities in asymptomatic babies can be detected in up to 27% of cases. The risk of recurrence of CHB is ten times higher. Most of the mothers are asymptomatic at delivery and are identified only by the birth of an affected child. Half of these asymptomatic women develop symptoms of a rheumatic disease, most commonly arthralgias and xerophtalmia, but few develop lupus nephritis. A standard therapy for CHB is still matter of investigation, although fluorinated corticosteroids have been reported to be effective for associated cardiomyopathy. Serial echocardiograms and obstetric sonograms, performed at least every 1–2 weeks starting from the 16th week of gestational age, are recommended in anti-Ro/SSA-positive pregnant women to detect early fetal abnormalities that might be a target of preventive therapy. PMID:20012231

  4. A full-duplex WDM-RoF system based on tunable optical frequency comb generator

    NASA Astrophysics Data System (ADS)

    Zhang, Chan; Ning, TiGang; Li, Jing; Pei, Li; Li, Chao; Ma, Shaoshuo

    2015-06-01

    A prototype of full-duplex wavelength-division-multiplexing-based radio-over-fiber (WDM-RoF) system using a single continuous wave (CW) laser at central station (CS) is proposed and investigated. In the proposal, the tunable optical frequency comb (OFC) generator is performed by cascading an electro-absorption modulator (EAM), a phase modulator (PM) and a Mach-Zehnder intensity modulator (IM). Then the proposed OFC is used as the source of WDM-RoF network. The base station (BS) is simplified by using central carrier along with downlink multi-frequency millimeter-wave signals (MMWs). In the scheme, we obtain 21 comb lines within 0.2 dB power deviation with an interval about 10 GHz. Then we apply it to a bidirectional 1:7 WDM-RoF cellular network. For the downlink, three MMWs with frequencies of 40 GHz, 60 GHz and 80 GHz are obtained. For the uplink, 7 WDM channels carrying upstream signal are converted simultaneously. Both down and uplink delivery over 20 km transmission with less than 1 dB power penalty, which shows high spectral-efficiency and good performance over long-distance delivery.

  5. Isoprene NO3 Oxidation Products from the RO2 + HO2 Pathway.

    PubMed

    Schwantes, Rebecca H; Teng, Alexander P; Nguyen, Tran B; Coggon, Matthew M; Crounse, John D; St Clair, Jason M; Zhang, Xuan; Schilling, Katherine A; Seinfeld, John H; Wennberg, Paul O

    2015-10-08

    We describe the products of the reaction of the hydroperoxy radical (HO(2)) with the alkylperoxy radical formed following addition of the nitrate radical (NO(3)) and O(2) to isoprene. NO(3) adds preferentially to the C(1) position of isoprene (>6 times more favorably than addition to C(4)), followed by the addition of O(2) to produce a suite of nitrooxy alkylperoxy radicals (RO(2)). At an RO(2) lifetime of ∼30 s, δ-nitrooxy and β-nitrooxy alkylperoxy radicals are present in similar amounts. Gas-phase product yields from the RO(2) + HO(2) pathway are identified as 0.75-0.78 isoprene nitrooxy hydroperoxide (INP), 0.22 methyl vinyl ketone (MVK) + formaldehyde (CH(2)O) + hydroxyl radical (OH) + nitrogen dioxide (NO(2)), and 0-0.03 methacrolein (MACR) + CH(2)O + OH + NO(2). We further examined the photochemistry of INP and identified propanone nitrate (PROPNN) and isoprene nitrooxy hydroxyepoxide (INHE) as the main products. INHE undergoes similar heterogeneous chemistry as isoprene dihydroxy epoxide (IEPOX), likely contributing to atmospheric secondary organic aerosol formation.

  6. Quantum scattering calculations for ro-vibrational de-excitation of CO by hydrogen atoms

    SciTech Connect

    Song, Lei; Avoird, Ad van der; Karman, Tijs; Groenenboom, Gerrit C.; Balakrishnan, N.

    2015-05-28

    We present quantum-mechanical scattering calculations for ro-vibrational relaxation of carbon monoxide (CO) in collision with hydrogen atoms. Collisional cross sections of CO ro-vibrational transitions from v = 1, j = 0 − 30 to v′ = 0, j′ are calculated using the close coupling method for collision energies between 0.1 and 15 000 cm{sup −1} based on the three-dimensional potential energy surface of Song et al. [J. Phys. Chem. A 117, 7571 (2013)]. Cross sections of transitions from v = 1, j ≥ 3 to v′ = 0, j′ are reported for the first time at this level of theory. Also calculations by the more approximate coupled states and infinite order sudden (IOS) methods are performed in order to test the applicability of these methods to H–CO ro-vibrational inelastic scattering. Vibrational de-excitation rate coefficients of CO (v = 1) are presented for the temperature range from 100 K to 3000 K and are compared with the available experimental and theoretical data. All of these results and additional rate coefficients reported in a forthcoming paper are important for including the effects of H–CO collisions in astrophysical models.

  7. [Anti- SSA/Ro and Anti-SSB/ La Antibodies in Patients with Yusho].

    PubMed

    Tsuji, Hiroshi

    2015-05-01

    To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), anti-SSA/Ro and anti-SSB/La antibodies were studied in serum of 213 patients with Yusho and 63 control subjects in 2013. Anti-SSA/Ro antibodies were found in 4.2% (9/213) of patients with Yusho and 1.6% (1/63) of control subjects. The prevalence rates of anti-SSA/Ro antibodies in Yusho patients were not associated with blood PCB concentration or blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) concentration. Anti-SSB/La antibodies were found in 1.4% (3/213) of patients of Yusho, but none of controls. Furthermore, high concentrations of PCB and 2,3,4,7,8-PeCDF were present in Yusho patients with anti-SSB/La antibodies. We conclude that anti-SSB/La antibody is present in patients with Yusho, and it may be associated with PCB and 2,3,4,7,8-PeCDF in the blood.

  8. RoCoMAR: robots' controllable mobility aided routing and relay architecture for mobile sensor networks.

    PubMed

    Le, Duc Van; Oh, Hoon; Yoon, Seokhoon

    2013-07-05

    In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

  9. The relationship between anti-Ro (SS-A) antibody-positive Sjögren's syndrome and anti-Ro (SS-A) antibody-positive lupus erythematosus.

    PubMed

    Provost, T T; Talal, N; Harley, J B; Reichlin, M; Alexander, E

    1988-01-01

    Ten Ro(SS-A) antibody-positive patients with Sjögren's syndrome and lupus erythematosus are described. These patients have a disease process characterized by the frequent appearance of annular polycyclic lupus lesions of subacute cutaneous lupus erythematosus (SCLE), as well as neurologic and pulmonary disease. The Ro(SS-A) antibody-positive patients may have Sjögren's syndrome for many years and then suddenly develop lupus erythematosus, and vice versa. These studies demonstrate that the patient with Ro(SS-A) antibody may exhibit a dynamic clinical disease expression over time and that there is a closer pathologic relationship between Sjögren's syndrome and SCLE in these patients with Ro(SS-A)-antibody than has previously been appreciated. Furthermore, Ro(SS-A)-positive patients with Sjögren's syndrome and lupus erythematosus appear to have a much more guarded prognosis than those Ro(SS-A)-positive lupus patients described under the classifications of antinuclear antibody-negative lupus erythematosus and SCLE.

  10. A comparison of propranolol and compound RO3-4787 in the treatment of arterial hypertension in man.

    PubMed

    George, C F; Lewis, P J; Steiner, J A; Dollery, C T

    1975-06-01

    1. The effects of propranolol and RO3-4787, a new beta-adrenoceptor antagonist with a partial agonist activity, have been studied in a blind, cross-over comparison with placebo. 2. In ten patients who completed the study, the two drugs produced a similar reduction in blood pressure; the reduction in heart rate with propranolol was significantly (P less than 0.001) greater than that produced by RO3-4787. 3. Plasma renin activity averaged 4.13 +/- 1.37 ng h-1 ml-1 on placebo, fell to 3.64 +/- 1.47 ng h-1 ml-1 on propranolol and to 2.50 +/- 1.39 ng h-1 ml-1 on RO3-4787. 4. No correlation was demonstrable between the log plasma concentration of either propranolol or RO3-4787 and change in blood pressure.

  11. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts.

    PubMed Central

    Garcia, S; Nascimento, J H; Bonfa, E; Levy, R; Oliveira, S F; Tavares, A V; de Carvalho, A C

    1994-01-01

    In this study, IgG fractions from sera of SLE patients with anti-Ro/SSA or anti-Ro/SSA and anti-La/SSB activity were tested in Langendorff preparations of adult rabbit hearts, aiming to reproduce the cardiac manifestations observed in neonatal lupus in an experimental model. The hearts were perfused with normal Tyrode's solution for 30 min, followed by perfusion with Tyrode's containing 0.3 mg/ml of anti-Ro/SSA- (or anti-Ro/La-) positive IgG (nine sera), anti-ribonucleoprotein (RNP)-positive IgG (five sera), or IgG fractions from normal donors (five sera). In one third of the experiments done with anti-Ro/La-positive IgG, heart block was observed. With the remaining fractions, a decrease in heart rate of 17.1% was observed, but normal sinus rhythm was maintained. The IgG fractions with anti-RNP activity (five experiments) and from normal sera (six experiments) reduced heart rates by 12.9 and 3.3%, respectively, but heart block was not observed. To further characterize the cellular mechanisms involved in the conduction disturbances observed in the whole rabbit hearts, we conducted experiments with ventricular myocytes isolated from young rabbit hearts, studied by whole cell patch-clamp technique. In these experiments, the slow inward currents were analyzed during the superfusion of the cell with normal Tyrode's solution and 5 min after superfusion with Tyrode's solution containing 0.3 mg/ml of anti-Ro/SSA- (or anti-Ro/La-) positive IgG (five sera), anti-RNP-positive IgG (three sera), or IgG from normal donors (four sera). Resting and action potential amplitudes were not affected by any of the sera used. The anti-Ro/SSA IgG fraction induced a mean reduction in the peak slow inward current of 31.6%. IgG fractions with anti-RNP activity reduced slow inward current by 4.4%, whereas IgG fractions from normal donors increased this current by 3.3%. IgG-free fractions from sera of patients with anti-Ro/SSA activity did not alter the peak slow inward current. These results

  12. Enzymatic cleaning of biofouled thin-film composite reverse osmosis (RO) membrane operated in a biofilm membrane reactor.

    PubMed

    Khan, Mohiuddin; Danielsen, Steffen; Johansen, Katja; Lorenz, Lindsey; Nelson, Sara; Camper, Anne

    2014-02-01

    Application of environmentally friendly enzymes to remove thin-film composite (TFC) reverse osmosis (RO) membrane biofoulants without changing the physico-chemical properties of the RO surface is a challenging and new concept. Eight enzymes from Novozyme A/S were tested using a commercially available biofouling-resistant TFC polyamide RO membrane (BW30, FilmTech Corporation, Dow Chemical Co.) without filtration in a rotating disk reactor system operated for 58 days. At the end of the operation, the accumulated biofoulants on the TFC RO surfaces were treated with the three best enzymes, Subtilisin protease and lipase; dextranase; and polygalacturonase (PG) based enzymes, at neutral pH (~7) and doses of 50, 100, and 150 ppm. Contact times were 18 and 36 h. Live/dead staining, epifluorescence microscopy measurements, and 5 μm thick cryo-sections of enzyme and physically treated biofouled membranes revealed that Subtilisin protease- and lipase-based enzymes at 100 ppm and 18 h contact time were optimal for removing most of the cells and proteins from the RO surface. Culturable cells inside the biofilm declined by more than five logs even at the lower dose (50 ppm) and shorter incubation period (18 h). Subtilisin protease- and lipase-based enzyme cleaning at 100 ppm and for 18 h contact time restored the hydrophobicity of the TFC RO surface to its virgin condition while physical cleaning alone resulted in a 50° increase in hydrophobicity. Moreover, at this optimum working condition, the Subtilisin protease- and lipase-based enzyme treatment of biofouled RO surface also restored the surface roughness measured with atomic force microscopy and the mass percentage of the chemical compositions on the TFC surface estimated with X-ray photoelectron spectroscopy to its virgin condition. This novel study will encourage the further development and application of enzymes to remove biofoulants on the RO surface without changing its surface properties.

  13. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

    NASA Technical Reports Server (NTRS)

    Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard

    2010-01-01

    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

  14. A search for pulsations in the HgMn star HD 45975 with CoRoT photometry and ground-based spectroscopy

    NASA Astrophysics Data System (ADS)

    Morel, T.; Briquet, M.; Auvergne, M.; Alecian, G.; Ghazaryan, S.; Niemczura, E.; Fossati, L.; Lehmann, H.; Hubrig, S.; Ulusoy, C.; Damerdji, Y.; Rainer, M.; Poretti, E.; Borsa, F.; Scardia, M.; Schmid, V. S.; Van Winckel, H.; De Smedt, K.; Pápics, P. I.; Gameiro, J. F.; Waelkens, C.; Fagas, M.; Kamiński, K.; Dimitrov, W.; Baglin, A.; Michel, E.; Dumortier, L.; Frémat, Y.; Hensberge, H.; Jorissen, A.; Van Eck, S.

    2014-01-01

    The existence of pulsations in HgMn stars is still being debated. To provide the first unambiguous observational detection of pulsations in this class of chemically peculiar objects, the bright star HD 45975 was monitored for nearly two months by the CoRoT satellite. Independent analyses of the light curve provide evidence of monoperiodic variations with a frequency of 0.7572 d-1 and a peak-to-peak amplitude of ~2800 ppm. Multisite, ground-based spectroscopic observations overlapping the CoRoT observations show the star to be a long-period, single-lined binary. Furthermore, with the notable exception of mercury, they reveal the same periodicity as in photometry in the line moments of chemical species exhibiting strong overabundances (e.g., Mn and Y). In contrast, lines of other elements do not show significant variations. As found in otherHgMn stars, the pattern of variability consists in an absorption bump moving redwards across the line profiles. We argue that the photometric and spectroscopic changes are more consistent with an interpretation in terms of rotational modulation of spots at the stellar surface. In this framework, the existence of pulsations producing photometric variations above the ~50 ppm level is unlikely in HD 45975. This provides strong constraints on the excitation/damping of pulsation modes in this HgMn star. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. This work is based on observations collected at La Silla and Paranal Observatories, ESO (Chile), with the HARPS and UVES spectrographs at the 3.6-m and very large telescopes, under programmes LP185.D-0056 and 287.D-5066. It is also based on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias

  15. The CoRoT B-type binary HD 50230: a prototypical hybrid pulsator with g-mode period and p-mode frequency spacings⋆

    NASA Astrophysics Data System (ADS)

    Degroote, P.; Aerts, C.; Michel, E.; Briquet, M.; Pápics, P. I.; Amado, P.; Mathias, P.; Poretti, E.; Rainer, M.; Lombaert, R.; Hillen, M.; Morel, T.; Auvergne, M.; Baglin, A.; Baudin, F.; Catala, C.; Samadi, R.

    2012-06-01

    Context. B-type stars are promising targets for asteroseismic modelling, since their frequency spectrum is relatively simple. Aims: We deduce and summarise observational constraints for the hybrid pulsator, HD 50230, earlier reported to have deviations from a uniform period spacing of its gravity modes. The combination of spectra and a high-quality light curve measured by the CoRoT satellite allow a combined approach to fix the position of HD 50230 in the HR diagram. Methods: To describe the observed pulsations, classical Fourier analysis was combined with short-time Fourier transformations and frequency spacing analysis techniques. Visual spectra were used to constrain the projected rotation rate of the star and the fundamental parameters of the target. In a first approximation, the combined information was used to interpret multiplets and spacings to infer the true surface rotation rate and a rough estimate of the inclination angle. Results: We identify HD 50230 as a spectroscopic binary and characterise the two components. We detect the simultaneous presence of high-order g modes and low-order p and g-modes in the CoRoT light curve, but were unable to link them to line profile variations in the spectroscopic time series. We extract the relevant information from the frequency spectrum, which can be used for seismic modelling, and explore possible interpretations of the pressure mode spectrum. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. Based on observations made with the ESO telescopes at La Silla Observatory under the ESO Large Programme LP182.D-0356, and on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, and on observations obtained with the HERMES

  16. Pre-Clinical studies of Notch Signaling Inhibitor RO4929097 in Inflammatory Breast Cancer Cells

    PubMed Central

    Debeb, Bisrat G.; Cohen, Evan N.; Boley, Kimberly; Freiter, Erik M.; Li, Li; Robertson, Fredika M.; Reuben, James M.; Cristofanilli, Massimo; Buchholz, Thomas A.; Woodward, Wendy A.

    2015-01-01

    Basal breast cancer, common among patients presenting with inflammatory breast cancer, has been shown to be resistant to radiation and enriched in cancer stem cells. The Notch pathway plays an important role in self-renewal of breast cancer stem cells and contributes to inflammatory signaling that promotes the breast cancer stem cell phenotype. Herein we inhibited Notch signaling using a gamma secretase inhibitor, RO4929097, in an in vitro model that enriches for cancer initiating cells (3D clonogenic assay) and conventional 2D clonogenic assay to compare the effect on radiosensitization of the SUM149 and SUM190 inflammatory breast cancer (IBC) cell lines. RO4929097 downregulated the Notch target genes Hes1, Hey1 and HeyL and showed a significant reduction in anchorage independent growth in SUM190 and SUM149. However, the putative self-renewal assay mammosphere formation efficiency was increased with the drug. To assess radiosensitization of putative cancer stem cells, cells were exposed to increasing doses of radiation with or without 1uM RO4929097 in their standard (2D) and self-renewal enriching (3D) culture conditions. In the conventional 2D clonogenic assay, RO4929097 significantly sensitized SUM190 cells to ionizing radiation and has a modest radiosensitization effect in SUM149 cells. In the 3D clonogenic assays, however, a radioprotective effect was seen in both SUM149 and SUM190 cells at higher doses. Both cell lines express IL-6 and IL-8, cytokines known to mediate the efficacy of notch inhibition and to promote self-renewal of stem cells. We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-α, a potential mediator of IL-6 and IL-8 production in the microenvironment. These data suggest additional targeting agents may be required to selectively target IBC stem cells through notch inhibition, and that evaluation of microenvironmental influences may shed further light on the potential effects of this

  17. Galactic archaeology with asteroseismology and spectroscopy: Red giants observed by CoRoT and APOGEE

    NASA Astrophysics Data System (ADS)

    Anders, F.; Chiappini, C.; Rodrigues, T. S.; Miglio, A.; Montalbán, J.; Mosser, B.; Girardi, L.; Valentini, M.; Noels, A.; Morel, T.; Johnson, J. A.; Schultheis, M.; Baudin, F.; de Assis Peralta, R.; Hekker, S.; Themeßl, N.; Kallinger, T.; García, R. A.; Mathur, S.; Baglin, A.; Santiago, B. X.; Martig, M.; Minchev, I.; Steinmetz, M.; da Costa, L. N.; Maia, M. A. G.; Allende Prieto, C.; Cunha, K.; Beers, T. C.; Epstein, C.; García Pérez, A. E.; García-Hernández, D. A.; Harding, P.; Holtzman, J.; Majewski, S. R.; Mészáros, Sz.; Nidever, D.; Pan, K.; Pinsonneault, M.; Schiavon, R. P.; Schneider, D. P.; Shetrone, M. D.; Stassun, K.; Zamora, O.; Zasowski, G.

    2017-01-01

    With the advent of the space missions CoRoT and Kepler, it has recently become feasible to determine precise asteroseismic masses and relative ages for large samples of red giant stars. We present the CoRoGEE dataset, obtained from CoRoT light curves for 606 red giants in two fields of the Galactic disc that have been co-observed by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). We used the Bayesian parameter estimation code PARAM to calculate distances, extinctions, masses, and ages for these stars in a homogeneous analysis, resulting in relative statistical uncertainties of ≲2% in distance, 4% in radius, 9% in mass and 25% in age. We also assessed systematic age uncertainties stemming from different input physics and mass loss. We discuss the correlation between ages and chemical abundance patterns of field stars over a broad radial range of the Milky Way disc (5 kpc RoGEE observations of a chemodynamical Milky Way disc model indicate that the number of high-metallicity stars in the outer disc is too high to be accounted for even by the strong radial mixing present in the model. The mock observations also show that the age distribution of the [α/Fe]-enhanced sequence in the CoRoGEE inner-disc field is much broader than expected from a combination of radial mixing and observational errors. We suggest that a thick-disc/bulge component that formed stars for more than 3 Gyr may account for these discrepancies. Our results are subject to future improvements due to (a) the still low statistics, because our sample had to be

  18. Evaluation of the ethanol antagonist' Ro15-4513 on cardiovascular and metabolic responses induced by ethanol

    SciTech Connect

    Lerner, M.R.; Gauvin, D.V.; Holloway, F.A.; Wilson, M.F.; Brackett, D.J. Veterans Affairs Medical Center, Oklahoma City, OK )

    1992-02-26

    The putative ethanol antagonist Ro15-4513 has been reported to attenuate many behavioral responses induced by ethanol, including motor coordination, narcosis, ethanol self administration and intake, and anticonvulsant actions. This study was designed to study the effect of Ro15-4513 on cardiovascular and metabolic responses elicited by intragastric ethanol in conscious rats. Four groups of rats were catheterized under enflurane anesthesia and allowed to regain consciousness. Each group was given either 3.2, 10.0, or 32.0 mg/kg Ro15-4513 or equivalent Tween (i.p.) following ethanol. Ro15-4513 had no effect at any concentration on the decreases in mean arterial pressure, cardiac output, central venous pressure, respiration rate, and cardiac stroke volume and the increases in systemic vascular resistance, heart rate, and glucose evoked by the ethanol challenge. Blood alcohol concentrations measured throughout the study were not affected by any concentration of Ro15-4513. These data suggest that even though Ro15-4513 has significant effects on behavioral responses induced by ethanol it has no effect on the cardiovascular and metabolic responses elicited during ethanol intoxication.

  19. Determination of the in vivo redox potential using roGFP and fluorescence spectra obtained from one-wavelength excitation

    NASA Astrophysics Data System (ADS)

    Wierer, S.; Elgass, K.; Bieker, S.; Zentgraf, U.; Meixner, A. J.; Schleifenbaum, F.

    2011-02-01

    The analysis of molecular processes in living (plant) cells such as signal transduction, DNA replication, carbon metabolism and senescence has been revolutionized by the use of green fluorescent protein (GFP) and its variants as specific cellular markers. Many cell biological processes are accompanied by changes in the intracellular redox potential. To monitor the redox potential, a redox-sensitive mutant of GFP (roGFP) was created, which shows changes in its optical properties in response to changes in the redox state of its surrounding medium. For a quantitative analysis in living systems, it is essential to know the optical properties of roGFP in vitro. Therefore, we applied spectrally resolved fluorescence spectroscopy on purified roGFP exposed to different redox potentials to determine shifts in both the absorption and the emission spectra of roGFP. Based on these in vitro findings, we introduce a new approach using one-wavelength excitation to use roGFP for the in vivo analysis of cell biological processes. We demonstrate the ability this technique by investigating chloroplast-located Grx1-roGFP2 expressing Arabidopsis thaliana cells as example for dynamically moving intracellular compartments. This is not possible with the two-wavelength excitation technique established so far, which hampers a quantitative analysis of highly mobile samples due to the time delay between the two measurements and the consequential displacement of the investigated area.

  20. Standard and Short RoM Isokinetic Testing: Comparative Analysis in Identifying Submaximal Shoulder External Rotator Effort.

    PubMed

    Pujol, Eduard; Chaler, Joaquim; Sucarrats, Laura; López, Inés; Zeballos, Blanca; Garreta, Roser; Dvir, Zeevi

    2017-01-31

    An isokinetic-related parameter termed the difference between eccentric-concentric strength ratios at two distinct test velocities (DEC) based on 60° (standard) range of motion (RoM) has been proven to be highly efficient detecting feigned muscular efforts. This study aimed to verify whether a DEC derived from a much shorter test RoM (20°) was equally useful than a long RoM-derived one. Eighteen healthy men (32.4 ± 6.4 years old) took part in a study focusing on shoulder external rotation isokinetic strength. Participants performed a genuine shoulder external rotator maximal effort (eight pairs of concentric and eccentric contractions at high and low velocities at short and long RoM) and then instructed to feign maximal effort. Contraction velocities were adjusted accordingly by applying a 1:4 gradient and peak moments registered. Both condition DEC was then calculated by subtracting the eccentric and concentric strength ratios at low velocities from those at high velocities. DEC scores in the feigned effort were significantly higher than maximal effort ones in both conditions in men. It enabled the setting of specific cutoff levels for separating the efforts. Both approaches revealed a coincident sensitivity (78%) whereas short RoM showed an even higher specificity: 88% versus 78%. Thus, the short RoM protocol provides clinically acceptable detection power.

  1. The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.

    PubMed

    Simons, F H; Rutjes, S A; van Venrooij, W J; Pruijn, G J

    1996-03-01

    Ro RNPs are evolutionarily conserved ribonucleoprotein particles that consist of a small RNA, known as Y RNA, associated with several proteins, such as La, Ro60, and Ro52. The Y RNAs (Y1-Y5), which are transcribed by RNA polymerase III, have been shown to reside almost exclusively in the cytoplasm as Ro RNPs. To obtain more insight into the nuclear export pathway of Y RNAs, hY1 RNA export was studied in Xenopus laevis oocytes. Injection of various hY1 RNA mutants showed that an intact Ro60 binding site is a prerequisite for nuclear export, whereas the presence of an intact La binding site resulted in strong nuclear retention of hY1 RNA. Competition studies with various classes of RNAs indicated that, in addition to Ro60, another titratable factor was necessary for nuclear export of hY1 RNA. This factor appears also to be involved in nuclear export of tRNA. Because export of hY1 RNA could not be blocked by a synthetic peptide containing the recently identified nuclear export signal of the HIV-1 Rev protein, nuclear export of hY1 RNA does not seem to be dependent on a Rev-like nuclear export signal.

  2. The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.

    PubMed Central

    Simons, F H; Rutjes, S A; van Venrooij, W J; Pruijn, G J

    1996-01-01

    Ro RNPs are evolutionarily conserved ribonucleoprotein particles that consist of a small RNA, known as Y RNA, associated with several proteins, such as La, Ro60, and Ro52. The Y RNAs (Y1-Y5), which are transcribed by RNA polymerase III, have been shown to reside almost exclusively in the cytoplasm as Ro RNPs. To obtain more insight into the nuclear export pathway of Y RNAs, hY1 RNA export was studied in Xenopus laevis oocytes. Injection of various hY1 RNA mutants showed that an intact Ro60 binding site is a prerequisite for nuclear export, whereas the presence of an intact La binding site resulted in strong nuclear retention of hY1 RNA. Competition studies with various classes of RNAs indicated that, in addition to Ro60, another titratable factor was necessary for nuclear export of hY1 RNA. This factor appears also to be involved in nuclear export of tRNA. Because export of hY1 RNA could not be blocked by a synthetic peptide containing the recently identified nuclear export signal of the HIV-1 Rev protein, nuclear export of hY1 RNA does not seem to be dependent on a Rev-like nuclear export signal. PMID:8608450

  3. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo.

    PubMed

    Lewis, E J; Bishop, J; Bottomley, K M; Bradshaw, D; Brewster, M; Broadhurst, M J; Brown, P A; Budd, J M; Elliott, L; Greenham, A K; Johnson, W H; Nixon, J S; Rose, F; Sutton, B; Wilson, K

    1997-06-01

    1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respectively). The compound is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). 2. Ro 32-3555 inhibited interleukin-1 alpha (IL-1 alpha)-induced cartilage collagen degradation in vitro in bovine nasal cartilage explants (IC50 = 60 nM). 3. Ro 32-3555 was well absorbed in rats when administered orally. Systemic exposure was dose related, with an oral bioavailability of 26% at a dose of 25 mg kg-1. 4. Ro 32-3555 prevented granuloma-induced degradation of bovine nasal cartilage cylinders implanted subcutaneously into rats (ED50 = 10 mg kg-1, twice daily, p.o.). 5. Ro 32-3555 dosed once daily for 14 days at 50 mg kg-1, p.o., inhibited degradation of articular cartilage in a rat monoarthritis model induced by an intra-articular injection of Propionibacterium acnes. 6. Ro 32-3555 is a potential therapy for the treatment of the chronic destruction of articulating cartilage in both rheumatoid and osteoarthritis.

  4. Origin of rhyolite by crustal melting and the nature of parental magmas in the Oligocene Conejos Formation, San Juan Mountains, Colorado, USA

    NASA Astrophysics Data System (ADS)

    Parker, D. F.; Ghosh, A.; Price, C. W.; Rinard, B. D.; Cullers, R. L.; Ren, M.

    2005-01-01

    Four closely spaced volcanoes (Summer Coon; Twin Mountains; Del Norte; Carnero Creek) form the east-central cluster of Conejos volcanic centers. These Conejos rocks range from high-K basaltic andesite to rhyolite, with andesite volumetrically the most abundant. Summer Coon and Twin Mountains are composite volcanoes. The Del Norte and Carnero Creek volcanoes are deeply eroded dacite shields. Rhyolite (10% of our Conejos analyses but a much smaller percentage by volume) is only known from Summer Coon and Twin Mountains volcanoes, although high-SiO 2 dacite occurs in the Del Norte volcano. The younger Hinsdale Formation contains a related series ranging from transitional basalt to high-K andesite; we use Hinsdale Formation analyses to represent Conejos parental magmas. Conejos and Hinsdale magmas evolved through AFC processes: Basalt, after interacting with lower crust, assimilated low K/Rb crust, similar in some ways to Taylor and McLennan (Taylor, S.R., and McLennan, S.M., 1985, The continental crust: its composition and evolution. Oxford, Blackwell Scientific.) model upper crust; main series basaltic andesite fractionated to high-K andesite; rhyolite was produced by melting of high K/Ba upper crustal rocks similar to granite gneiss known from inclusions and basement outcrops. Some rhyolite may have been back-mixed into fractionating andesite and dacite. Field evidence for assimilation includes sanidinite-facies, partially melted, gneiss blocks up to 1 m in diameter. Temperature estimates (1100-900 ° C) from two-pyroxene equilibria are consistent with this interpretation, as are the sparsely porphyritic nature of the most-evolved rhyolites and the absence of phenocrystic alkali feldspar. Our study supports the conclusions of previous workers on AFC processes in similar, but generally more mafic, Conejos magmas of the southeastern San Juan Mountains. Our results, however, emphasize the importance of crustal melting in the generation of Conejos rhyolite. We further

  5. HD 50844: a new look at δ Scuti stars from CoRoT space photometry

    NASA Astrophysics Data System (ADS)

    Poretti, E.; Michel, E.; Garrido, R.; Lefèvre, L.; Mantegazza, L.; Rainer, M.; Rodríguez, E.; Uytterhoeven, K.; Amado, P. J.; Martín-Ruiz, S.; Moya, A.; Niemczura, E.; Suárez, J. C.; Zima, W.; Baglin, A.; Auvergne, M.; Baudin, F.; Catala, C.; Samadi, R.; Alvarez, M.; Mathias, P.; Paparò, M.; Pápics, P.; Plachy, E.

    2009-10-01

    Context: Aims: This work presents the results obtained by CoRoT on HD 50844, the only δ Sct star observed in the CoRoT initial run (57.6 d). The aim of these CoRoT observations was to investigate and characterize for the first time the pulsational behaviour of a δ Sct star, when observed at a level of precision and with a much better duty cycle than from the ground. Methods: The 140 016 datapoints were analysed using independent approaches (SigSpec software and different iterative sine-wave fittings) and several checks performed (splitting of the timeseries in different subsets, investigation of the residual light curves and spectra). A level of 10-5 mag was reached in the amplitude spectra of the CoRoT timeseries. The space monitoring was complemented by ground-based high-resolution spectroscopy, which allowed the mode identification of 30 terms. Results: The frequency analysis of the CoRoT timeseries revealed hundreds of terms in the frequency range 0-30 d-1. All the cross-checks confirmed this new result. The initial guess that δ Sct stars have a very rich frequency content is confirmed. The spectroscopic mode identification gives theoretical support since very high-degree modes (up to ℓ=14) are identified. We also prove that cancellation effects are not sufficient in removing the flux variations associated to these modes at the noise level of the CoRoT measurements. The ground-based observations indicate that HD 50844 is an evolved star that is slightly underabundant in heavy elements, located on the Terminal Age Main Sequence. Probably due to this unfavourable evolutionary status, no clear regular distribution is observed in the frequency set. The predominant term (f_1=6.92 d-1) has been identified as the fundamental radial mode combining ground-based photometric and spectroscopic data. Conclusions: The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria

  6. CoRoT light curves of Blazhko RR Lyrae stars. Evidence of a strong correlation between phase and amplitude modulations of CoRoT ID 0105288363

    NASA Astrophysics Data System (ADS)

    Chadid, M.; Perini, C.; Bono, G.; Auvergne, M.; Baglin, A.; Weiss, W. W.; Deboscher, J.

    2011-03-01

    Context. The CoRoT - Convection Rotation and planetary Transits - space mission provides a unique opportunity to monitor RR Lyrae stars with excellent time-sampling, unprecedented photometric precision, and a long time base of 150 days. Aims: The pulsation characteristics of RR Lyrae stars rely on robust physics, but we still lack a firm quantitative understanding of the physical mechanisms driving the Blazhko modulation and the long-term changes in their pulsation behavior. We use the high-precision space data of an unknown RR Lyrae star CoRoT ID 0105288363 observed during a second long run centered on the Galaxy - LRc02 -, to improve our understanding of the pulsation properties of RR Lyrae stars. Methods: The CoRoT data were corrected using a jump and trend filtering code. We applied different period-finding techniques including Period04, MuFrAn, PDM, and SigSpec. Amplitude and phase modulation were investigated using an analytical function method as well as traditional O-C diagrams. Results: For the first time, we detect significant cycle-to-cycle changes in the Blazhko modulation, which appear to be analogous to those predicted by Stothers - owing to the suppression of turbulent convection - to explain this phenomenon. We discuss the clear correlations between the phase and the amplitude of the bump, and the skewness and acuteness of the light curve during different Blazhko cycles. We find that these quantities are strongly anticorrelated with the fundamental pulsation period. This provides a strong support to the slow convective cycle model suggested by Stothers. We also detect a long-term modulation period in the maximum brightness spectrum. A more extended coverage of the long-term modulation is required to constrain its period. Seventh-order side peaks of the pulsation multiplet structure are also visible with the left-side peak amplitudes being higher than those of the right. This has never previously been detected. Future theoretical investigations are

  7. Nontronite from a low-temperature hydrothermal system on the Juan de Fuca Ridge

    USGS Publications Warehouse

    Murnane, R.; Clague, D.A.

    1983-01-01

    A deposit of Fe-rich, Al-poor, hydrothermal nontronite was recovered from the Juan de Fuca Ridge. Analyses show the deposit to be mineralogically and chemically similar to nontronite described at other oceanic localities. The deposit is located near the tip of a propagating segment of the Juan de Fuca Ridge. Rare earth elements and Sr isotopes indicate that the nontronite precipitated from seawater. A formation temperature of 57??C is suggested by oxygen isotopic composition. The low-temperature nontronite deposits apparently form from newly established hydrothermal systems associated with the propagating rift segment. More mature hydrothermal systems that deposit sulfide on the seafloor may develop from these low-temperature systems. ?? 1983.

  8. SPM4: The Yale/San-Juan Southern Proper Motion survey: 100 million absolute proper motions

    NASA Astrophysics Data System (ADS)

    van Altena, W. F.; Girard, T. M.; Casetti, D. I.; Vieira, K.; López, C. E.; Castillo, D.; Monet, D.; Zacharias, N.; Korchagin, V. I.; Platais, I.; Lee, Y. S.; Beers, T. C.; Herrera, D.

    The Yale/San Juan Southern Proper Motion SPM4 Catalog is the culmi- nation of a highly successful 47-year collaboration between the National University of San Juan (UNSJ) and the Yale Southern Observatory (YSO). The SPM4 Catalog contains absolute proper motions, celestial coordinates, blue and visual passband photometry for 103,319,647 stars and galaxies be- tween the south celestial pole and -20 degrees declination. The Catalog is roughly complete to V=17.5 and the precision of its positions and absolute proper motions is approximately 30 to 150 mas and 2 to 10 mas/yr, respec- tively. It is based on photographic and CCD observations taken with the Yale Southern Observatory's double-astrograph at the Cesco Observatory in El Leoncito, Argentina.

  9. ["Is it an animal inside? "Melanie Klein's unpublished Don Juan Paper (1939)].

    PubMed

    Frank, Claudia

    2008-01-01

    Klein had been asked to contribute an article to the birthday number of the International Journal for Jones. The author outlines how she hurriedly wrote a text about Don Juan which, however, was rejected by the editor. Essential parts of it are presented in German translation. The manuscript is discussed in the context of Klein's published work as well as of the relevant contemporary literature. In Klein's view, Don Juan's genitality is determined by oral impulses and fears. By his manic acting out he attempts to ward off a depressive break-down. The paper ends with some reflections about why Klein--ontrary to her intention--failed to revise her manuscript for later publication.

  10. Abiotic nitrous oxide emission from the hypersaline Don Juan Pond in Antarctica

    NASA Astrophysics Data System (ADS)

    Samarkin, Vladimir A.; Madigan, Michael T.; Bowles, Marshall W.; Casciotti, Karen L.; Priscu, John C.; McKay, Christopher P.; Joye, Samantha B.

    2010-05-01

    Nitrous oxide is a potent atmospheric greenhouse gas that contributes to ozone destruction. Biological processes such as nitrification and denitrification are thought to drive nitrous oxide production in soils, which comprise the largest source of nitrous oxide to the atmosphere. Here we present measurements of the concentration and isotopic composition of nitrous oxide in soil pore spaces in samples taken near Don Juan Pond, a metabolically dormant hypersaline pond in Southern Victoria Land, Antarctica in 2006, 2007 and 2008, together with in situ fluxes of nitrous oxide from the soil to the atmosphere. We find fluxes of nitrous oxide that rival those measured in fertilized tropical soils. Laboratory experiments-in which nitrite-rich brine was reacted with a variety of minerals containing Fe(II)-reveal a new mechanism of abiotic water-rock reaction that could support nitrous oxide fluxes at Don Juan Pond. Our findings illustrate a dynamic and unexpected link between the geosphere and atmosphere.

  11. Further paleomagnetic results for the San Juan volcanic field of southern Colorado

    USGS Publications Warehouse

    Beck, M.E.; Sheriff, S.D.; Diehl, J.F.; Hailwood, E.A.; Lipman, P.W.

    1977-01-01

    Combining paleomagnetic data for 17 new sites from the northwest portion of the (Oligocene) San Juan volcanic field of southern Colorado with data for 29 sites previously published yields a paleomagnetic pole at 85??N, 114??E (with a 95% confidence circle of 7.5?? radius). A further combination of the San Juan data with the results of other studies on rocks of Oligocene age from tectonically stable parts of North America gives a mid-Tertiary reference pole located at 81??N, 132.5??E, with a confidence circle of approximately 4??. Mid-Tertiary paleomagnetic poles for the western edge of the continent diverge markedly from this reference pole. ?? 1977.

  12. Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated with positive pregnancy outcomes in women at risk of congenital heart block.

    PubMed

    Tonello, Marta; Hoxha, Ariela; Mattia, Elena; Zambon, Alessandra; Visentin, Silvia; Cerutti, Alessia; Ghirardello, Anna; Milanesi, Ornella; Ruffatti, Amelia

    2017-05-01

    Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study. Anti-Ro52, anti-Ro60, anti-p200, and anti-La antibodies were assayed using home-made ELISA assays. Isolated antibody positivity was found in 25 women (15.3%), while multiple antibody positivity in 138 (84.7%). Twenty-four developed CHB, and the 139 had a favorable pregnancy outcome. The prevalence of isolated anti-Ro/SSA 60 kd antibodies was significantly higher (p < 0.046) as the prevalence of lower mean antibody titers (p < 0.0001) in the later group. Confirmation of these results by large-scale studies could lead clinicians to recommend less stringent fetal echocardiography monitoring in women with isolated anti-Ro/SSA 60 kd antibodies.

  13. Elevated IL-1β levels in anti-Ro/SSA connective tissue diseases patients with prolonged corrected QTc interval.

    PubMed

    Pisoni, Cecilia N; Reina, Silvia; Arakaki, Diego; Eimon, Alicia; Carrizo, Carolina; Borda, Enri

    2015-01-01

    Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) have increased IL-1β levels. IL-1β and other pro-inflammatory cytokines have a modulating activity on cardiac ion channels and have been associated with increased arrhythmic risk in rheumatoid arthritis patients. Likewise, adult patients with connective tissue diseases (CTDs) may have prolonged QTc intervals associated with the presence of anti-Ro/SSA antibodies. Our objective was to evaluate the presence of serum IL-1β in subjects with CTDs, in relation to the presence of anti-Ro/SSA antibodies and QTc interval duration. 12-lead electrocardiograms (ECG) were performed and blood was withdrawn, measuring electrolytes, IL-1β anti-Ro/SSA antibodies by ELISA in 73 patients with CTDs. 55 patients were anti-Ro/SSA positive and 18 were anti-Ro/SSA negative. Patients with anti-Ro/SSA positive antibodies had a significantly greater median IL-1β serum level: 7.29 (range: 0.17-17.3 pg/ml) compared to patients with anti-Ro/SSA negative antibodies whose median was: 1.67 (range 0.55-4.12 pg/ml) p<0.001. The mean QTc interval values obtained in both groups were not significantly different (417.7±23.1 vs. 414.7±21.2, p=0.63). The QTc interval was prolonged in 11 (20%) patients, who were all anti-Ro/SSA positive versus 0 (0 %) in anti-Ro/SSA negative patients p=0.05. Median IL-1β levels were: 8.7 (range: 2.69-15.1 pg/ml) in patients with prolonged QTc interval versus median: 5.0 (range: 0.17-17.3 pg/ml) in those with normal QTc interval values (<440ms) p=0.006. IL-1β is elevated in patients with CTDs that have both anti-Ro/SSA antibodies and prolonged QTc intervals.

  14. View of sand dunes in the San Juan Province of Western Argentina

    NASA Image and Video Library

    1975-07-20

    AST-27-2341 (20 July 1975) --- A near vertical view of sand dunes in the San Juan Province of Western Argentina, as photographed from the Apollo spacecraft in Earth orbit during the joint U.S.-USSR Apollo-Soyuz Test Project mission. The picture was taken at an altitude of 220 kilometers (136 statute miles) with a 70mm Hasselblad camera using medium-speed Ektachrome QX-807 type film.

  15. Juan César García: social medicine as project and endeavor.

    PubMed

    Nunes, Everardo Duarte

    2015-01-01

    This paper analyses some aspects of the trajectory of the Argentinian physician and sociologist Juan César García (1932-1984) in the field of Latin American Social Medicine. Three dimensions constituting his basic orientations are highlighted: the elaboration of systematic and reflective social thought; a critical attitude in questioning teaching and professional practices; a commitment to the institutionalization and dissemination of health knowledge.

  16. No spreading across the southern Juan de Fuca ridge axial cleft during 1994-1996

    USGS Publications Warehouse

    Chadwell, C.D.; Hildebrand, J.A.; Spiess, Fred N.; Morton, J.L.; Normark, W.R.; Reiss, C.A.

    1999-01-01

    Direct-path acoustic measurements between seafloor transponders observed no significant extension (-10 ?? 14 mm/yr) from August 1994 to September 1996 at the southern Juan de Fuca Ridge (44??40' N and 130??20' W). The acoustic path for the measurement is a 691-m baseline straddling the axial cleft, which bounds the Pacific and Juan de Fuca plates. Given an expected full-spreading rate of 56 mm/yr, these data suggest that extension across this plate boundary occurs episodically within the narrow (~1 km) region of the axial valley floor, and that active deformation is occurring between the axial cleft and the plate interior. A cleft-parallel 714-m baseline located 300 m to the west of the cleft on the Pacific plate monitored system performance and, as expected, observed no motion (+5??7 mm/yr) between the 1994 and 1996 surveys.Direct-path acoustic measurements between seafloor transponders observed no significant extension (-10 ?? 14 mm/yr) from August 1994 to September 1996 at the southern Juan de Fuca Ridge (44??40 minutes N and 130??20 minutes W). The acoustic path for the measurement is a 691-m baseline straddling the axial cleft, which bounds the Pacific and Juan de Fuca plates. Given an expected full-spreading rate of 56 mm/yr, these data suggest that extension across this plate boundary occurs episodically within the narrow (approx. 1 km) region of the axial valley floor, and that active deformation is occurring between the axial cleft and the plate interior. A cleft-parallel 714-m baseline located 300 m to the west of the cleft on the Pacific plate monitored system performance and, as expected, observed no motion (+5 ?? 7 mm/yr) between the 1994 and 1996 surveys.

  17. Effects of hydrostatic pressure on growth of hyperthermophilic archaebacteria from the juan de fuca ridge.

    PubMed

    Reysenbach, A L; Deming, J W

    1991-04-01

    Two new strains (AL1 and AL2) of hyperthermophilic, sulfur-reducing, heterotrophic archaebacteria from high-temperature (350 degrees C) vents on the Juan de Fuca Ridge were highly barotolerant at their optimal growth temperatures (90 and 100 degrees C, respectively). A trend towards barophily at pressures greater than those encountered in situ at the sea floor was demonstrated for the more extremely thermophilic strain (AL2), implying an ability to thrive in (unexplored) habitats well below accessible vent formations.

  18. Juan Ruiz De Alarcón: Impairment as Empowerment in Early Modern Spain

    ERIC Educational Resources Information Center

    Clark, Gloria Bodtorf

    2016-01-01

    Juan Ruiz de Alarcón, a seventeenth-century writer and native of New Spain, so excelled at the craft of writing "comedias" that he is recognized as one of the great writers of early modern Spain. In his personal life Ruiz de Alarcón struggled with a significant bodily impairment, a large hump on both his back and front, which made him…

  19. Temporal Geochemistry Data from Five Springs in the Cement Creek Watershed, San Juan County, Colorado

    USGS Publications Warehouse

    Johnson, Raymond H.; Wirt, Laurie; Leib, Kenneth J.

    2008-01-01

    Temporal data from five springs in the Cement Creek watershed, San Juan County, Colorado provide seasonal geochemical data for further research in the formation of ferricretes. In addition, these data can be used to help understand the ground-water flow system. The resulting data demonstrate the difficulty in gathering reliable seasonal data from springs, show the unique geochemistry of each spring due to local geology, and provide seasonal trends in geochemistry for Tiger Iron Spring.

  20. Geologic map of the Cochetopa Park and North Pass Calderas, northeastern San Juan Mountains, Colorado

    USGS Publications Warehouse

    Lipman, Peter W.

    2012-01-01

    The San Juan Mountains in southwestern Colorado have long been known as a site of exceptionally voluminous mid-Tertiary volcanism, including at least 22 major ignimbrite sheets (each 150-5,000 km3) and associated caldera structures active at 33-23 Ma. Recent volcanologic and petrologic studies in the San Juan region have focused mainly on several ignimbrite-caldera systems: the southeastern area (Platoro complex), western calderas (Uncompahgre-Silverton-Lake City), and the central cluster (La Garita-Creede calderas). Far less studied has been the northeastern San Juan region, which occupies a transition between earlier volcanism in central Colorado and large-volume younger ignimbrite-caldera foci farther south and west. The present map is based on new field coverage of volcanic rocks in seventeen 7.5' quadrangles in northeastern parts of the volcanic field, high-resolution age determinations for 120 new sites, and petrologic studies involving several hundred new chemical analyses. This mapping and the accompanying lab results (1) document volcanic evolution of the previously unrecognized North Pass caldera and the morphologically beautifully preserved but enigmatic Cochetopa basin, including unique features not previously described from ignimbrite calderas elsewhere; (2) provide evidence for a more rapid recurrence of large ignimbrite eruptions than previously known elsewhere; (3) quantify the regional time-space-volume progression from the earlier Sawatch magmatic trend southward into the San Juan region; and (4) permit more rigorous comparison between the broad mid-Tertiary magmatic belt in the western U.S. Cordillera and the type continental-margin arc volcanism in the central Andes.

  1. Impacts of Urbanization in the Coastal Tropical City of San Juan, Puerto Rico

    NASA Technical Reports Server (NTRS)

    Comarazamy, Daniel E.; Gonzalez, Jorge E.; Luvall, Jeffrey C.; Rickman, Douglass

    2007-01-01

    Urban sprawl in tropical locations is rapidly accelerating and it is more evident in islands where a large percentage of the population resides along the coasts. This paper focuses on the analysis of the impacts of land use and land cover for urbanization in the tropical coastal city of San Juan, in the Caribbean island of Puerto Rico. A mesoscale numerical model, the Regional Atmospheric Modeling System (RAMS), is used to study the impacts of land use for urbanization in the environment including specific characteristics of the urban heat island in the San Juan Metropolitan Area (SJMA), one of the most noticeable urban cores of the Caribbean. The research also makes use of the observations obtained during the airborne San Juan Atlas Mission. Surface and raw insonde data from the mission are used to validate the atmospheric model yielding satisfactory results. Airborne high resolution remote sensing data are used to update the model's surface characteristics in order to obtain a more accurate and detailed configuration of the SJMA and perform a climate impact analysis based on land cover/land use (LCLU) changes. The impact analysis showed that the presence of the urban landscape of San Juan has an impact reflected in higher air temperatures over the area occupied by the city, with positive values of up to 2.5 degrees C, for the simulations that have specified urban LCLU indexes in the model's bottom boundary. One interesting result of the impact analysis was the finding of a precipitation disturbance shown as a difference in total accumulated rainfall between the present urban landscape and with a potential natural vegetation, apparently induced by the presence of the urban area. Results indicate that the urban-enhanced cloud formation and precipitation development occur mainly downwind of the city, including the accumulated precipitation. This spatial pattern can be explained by the presence of a larger urbanized area in the southwest sector of the city, and of

  2. Transform push, oblique subduction resistance, and intraplate stress of the Juan de Fuca plate

    USGS Publications Warehouse

    Wang, K.; He, J.; Davis, E.E.

    1997-01-01

    The Juan de Fuca plate is a small oceanic plate between the Pacific and North America plates. In the southernmost region, referred to as the Gorda deformation zone, the maximum compressive stress a, constrained by earthquake focal mechanisms is N-S. Off Oregon, and possibly off Washington, NW trending left-lateral faults cutting the Juan de Fuca plate indicate a a, in a NE-SW to E-W direction. The magnitude of differential stress increases from north to south; this is inferred from the plastic yielding and distribution of earthquakes throughout the Gorda deformation zone. To understand how tectonic forces determine the stress field of the Juan de Fuca plate, we have modeled the intraplate stress using both elastic and elastic-perfectly plastic plane-stress finite element models. We conclude that the right-lateral shear motion of the Pacific and North America plates is primarily responsible for the stress pattern of the Juan de Fuca plate. The most important roles are played by a compressional force normal to the Mendocino transform fault, a result of the northward push by the Pacific plate and a horizontal resistance operating against the northward, or margin-parallel, component of oblique subduction. Margin-parallel subduction resistance results in large N-S compression in the Gorda deformation zone because the force is integrated over the full length of the Cascadia subduction zone. The Mendocino transform fault serves as a strong buttress that is very weak in shear but capable of transmitting large strike-normal compressive stresses. Internal failure of the Gorda deformation zone potentially places limits on the magnitude of the fault-normal stresses being transmitted and correspondingly on the magnitude of strike-parallel subduction resistance. Transform faults and oblique subduction zones in other parts of the world can be expected to transmit and create stresses in the same manner. Copyright 1997 by the American Geophysical Union.

  3. Reflections on Don Juan and on the utility of the unhappy love affair.

    PubMed

    Bergel, Ernest

    2011-12-01

    Based on an unusual clinical experience of a teenage boy in child psychotherapy, two conclusions are proposed: (1) that the extremely unhappy, early love affairs that occur in most men's lives serve a valuable function in helping them separate from their mothers sufficiently to be able to realistically relate to appropriate marriage partners, and (2) that some Don Juans start new relationships in order to break them off, rather than the reverse.

  4. Juan Ruiz De Alarcón: Impairment as Empowerment in Early Modern Spain

    ERIC Educational Resources Information Center

    Clark, Gloria Bodtorf

    2016-01-01

    Juan Ruiz de Alarcón, a seventeenth-century writer and native of New Spain, so excelled at the craft of writing "comedias" that he is recognized as one of the great writers of early modern Spain. In his personal life Ruiz de Alarcón struggled with a significant bodily impairment, a large hump on both his back and front, which made him…

  5. Impacts of Urbanization in the Coastal Tropical City of San Juan, Puerto Rico

    NASA Technical Reports Server (NTRS)

    Comarazamy, Daniel E.; Gonzalez, Jorge E.; Luvall, Jeffrey C.; Rickman, Douglass

    2007-01-01

    Urban sprawl in tropical locations is rapidly accelerating and it is more evident in islands where a large percentage of the population resides along the coasts. This paper focuses on the analysis of the impacts of land use and land cover for urbanization in the tropical coastal city of San Juan, in the Caribbean island of Puerto Rico. A mesoscale numerical model, the Regional Atmospheric Modeling System (RAMS), is used to study the impacts of land use for urbanization in the environment including specific characteristics of the urban heat island in the San Juan Metropolitan Area (SJMA), one of the most noticeable urban cores of the Caribbean. The research also makes use of the observations obtained during the airborne San Juan Atlas Mission. Surface and raw insonde data from the mission are used to validate the atmospheric model yielding satisfactory results. Airborne high resolution remote sensing data are used to update the model's surface characteristics in order to obtain a more accurate and detailed configuration of the SJMA and perform a climate impact analysis based on land cover/land use (LCLU) changes. The impact analysis showed that the presence of the urban landscape of San Juan has an impact reflected in higher air temperatures over the area occupied by the city, with positive values of up to 2.5 degrees C, for the simulations that have specified urban LCLU indexes in the model's bottom boundary. One interesting result of the impact analysis was the finding of a precipitation disturbance shown as a difference in total accumulated rainfall between the present urban landscape and with a potential natural vegetation, apparently induced by the presence of the urban area. Results indicate that the urban-enhanced cloud formation and precipitation development occur mainly downwind of the city, including the accumulated precipitation. This spatial pattern can be explained by the presence of a larger urbanized area in the southwest sector of the city, and of

  6. The paradigm of paraglacial megafans of the San Juan river basin, Central Andes, Argentina

    NASA Astrophysics Data System (ADS)

    Suvires, Graciela M.

    2014-11-01

    The spatial distribution and several morphometric characteristics of the Quaternary alluvial fans of the San Juan River, in the province of San Juan, at the Central and Western part of Argentina, have been studied to classify them as paraglacial megafans, as well to ratify its depositional environmental conditions. The high sedimentary load exported by San Juan river from the Central Andes to the foreland depressions is estimated about 3,682,200 hm3. The large alluvial fans of Ullum-Zonda and Tulum valleys were deposited into deep tectonic depressions, during the Upper Pleistocene deglaciation stages. The outcome of collecting remotely sensed data, map and DEM data, geophysical data and much fieldwork gave access to morphometric, morphographic and morphogenetic data of these alluvial fans. The main drainage network was mapped on processed images using QGis (vers.2.0.1). Several fan morphometric parameters were measured, such as the size, the shape, the thickness, the surface areas and the sedimentary volume of exported load. The analyzed fans were accumulated in deep tectonic depressions, where the alluvium fill reaches 700 to 1200 m thick. Such fans do not reach the large size that other world megafans have, and this is due to tectonic obstacles, although the sedimentary fill average volume surpasses 514,000 hm3. The author proposes to consider Ullum-Zonda and Tulum alluvial fans as paraglacial megafans. According to the stratigraphic relationships of the tropical South American Rivers, the author considers that the San Juan paraglacial megafans would have occurred in the period before 24 ka BP , possibly corresponding to Middle Pleniglacial (ca 65-24ka BP). They record colder and more humid conditions compared with the present arid and dry conditions.

  7. Stellar Ro

    NASA Astrophysics Data System (ADS)

    Featherstone, Nicholas

    2017-05-01

    Our understanding of the interior dynamics that give rise to a stellar dynamo draws heavily from investigations of similar dynamics in the solar context. Unfortunately, an outstanding gap persists in solar dynamo theory. Convection, an indispensable component of the dynamo, occurs in the midst of rotation, and yet we know little about how the influence of that rotation manifests across the broad range of convective scales present in the Sun. We are nevertheless well aware that the interaction of rotation and convection profoundly impacts many aspects of the dynamo, including the meridional circulation, the differential rotation, and the helicity of turbulent EMF. The rotational constraint felt by solar convection ultimately hinges on the characteristic amplitude of deep convective flow speeds, and such flows are difficult to measure helioseismically. Those measurements of deep convective power which do exist disagree by orders of magnitude, and until this disagreement is resolved, we are left with the results of models and those less ambiguous measurements derived from surface observations of solar convection. I will present numerical results from a series of nonrotating and rotating convection simulations conducted in full 3-D spherical geometry. This presentation will focus on how convective spectra differ between the rotating and non-rotating models and how that behavior changes as simulations are pushed toward more turbulent and/or more rotationally-constrained regimes. I will discuss how the surface signature of rotationally-constrained interior convection might naturally lead to observable signatures in the surface convective pattern, such as supergranulation and a dearth of giant cells.

  8. Mantle flow geometry from ridge to trench beneath the Gorda-Juan de Fuca plate system

    NASA Astrophysics Data System (ADS)

    Martin-Short, Robert; Allen, Richard M.; Bastow, Ian D.; Totten, Eoghan; Richards, Mark A.

    2015-12-01

    Tectonic plates are underlain by a low-viscosity mantle layer, the asthenosphere. Asthenospheric flow may be induced by the overriding plate or by deeper mantle convection. Shear strain due to this flow can be inferred using the directional dependence of seismic wave speeds--seismic anisotropy. However, isolation of asthenospheric signals is challenging; most seismometers are located on continents, whose complex structure influences the seismic waves en route to the surface. The Cascadia Initiative, an offshore seismometer deployment in the US Pacific Northwest, offers the opportunity to analyse seismic data recorded on simpler oceanic lithosphere. Here we use measurements of seismic anisotropy across the Juan de Fuca and Gorda plates to reconstruct patterns of asthenospheric mantle shear flow from the Juan de Fuca mid-ocean ridge to the Cascadia subduction zone trench. We find that the direction of fastest seismic wave motion rotates with increasing distance from the mid-ocean ridge to become aligned with the direction of motion of the Juan de Fuca Plate, implying that this plate influences mantle flow. In contrast, asthenospheric mantle flow beneath the Gorda Plate does not align with Gorda Plate motion and instead aligns with the neighbouring Pacific Plate motion. These results show that asthenospheric flow beneath the small, slow-moving Gorda Plate is controlled largely by advection due to the much larger, faster-moving Pacific Plate.

  9. Fission-track dating of the tectonic development of the San Juan Islands, Washington.

    USGS Publications Warehouse

    Johnson, S.Y.; Zimmerman, R.A.; Naeser, C.W.; Whetten, J.T.

    1986-01-01

    Previous geological studies have indicated that the major thrusting event in the San Juan Islands was of late-early to late Cretaceous age. Geochronological data are consistent with these prior inferences and confirm that thrusting occurred between approx 105 and 75 m.y. Reset zircon fission-track dates indicate the possible presence of a reversed geothermal gradient in the Decatur terrain, the uppermost preserved thrust plate. If present, this gradient was probably produced by conductive heating, and possibly by shear heating associated with a now-eroded overlying thrust plate and thrust fault. Thrusting in the southern San Juan Islands was accompanied by uplift and resetting of apatite dates. The Haro formation, the Spieden group, and their basement (probably the Wrangellia terrain) did not experience this uplift and probably acted as a 'backstop' to thrusting. Uplift of the southern San Juan Islands was, therefore, probably mainly accommodated on the Haro fault. The Nanaimo basin formed in the foreland of this advancing thrust system, probably as a response to thrust-related loading. Eastern exposures of the Nanaimo group were uplifted prior to deposition of the Middle and Upper Eocene Padden member of the Chucknaut formation, perhaps along a reactivated Haro fault system. -J.M.H.

  10. Assessing Climate Variability Effects on Dengue Incidence in San Juan, Puerto Rico

    PubMed Central

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E.; Otis, Daniel; McCarthy, Matthew J.; Peña-Orellana, Marisol

    2014-01-01

    We test the hypothesis that climate and environmental conditions are becoming favorable for dengue transmission in San Juan, Puerto Rico. Sea Level Pressure (SLP), Mean Sea Level (MSL), Wind, Sea Surface Temperature (SST), Air Surface Temperature (AST), Rainfall, and confirmed dengue cases were analyzed. We evaluated the dengue incidence and environmental data with Principal Component Analysis, Pearson correlation coefficient, Mann-Kendall trend test and logistic regressions. Results indicated that dry days are increasing and wet days are decreasing. MSL is increasing, posing higher risk of dengue as the perimeter of the San Juan Bay estuary expands and shorelines move inland. Warming is evident with both SST and AST. Maximum and minimum air surface temperature extremes have increased. Between 1992 and 2011, dengue transmission increased by a factor of 3.4 (95% CI: 1.9–6.1) for each 1 °C increase in SST. For the period 2007–2011 alone, dengue incidence reached a factor of 5.2 (95% CI: 1.9–13.9) for each 1 °C increase in SST. Teenagers are consistently the age group that suffers the most infections in San Juan. Results help understand possible impacts of different climate change scenarios in planning for social adaptation and public health interventions. PMID:25216253

  11. The San Juan Canyon, southeastern Utah: A geographic and hydrographic reconnaissance

    USGS Publications Warehouse

    Miser, Hugh D.

    1924-01-01

    This report, which describes the San Juan Canyon, San Juan River and the tributary streams and the geography and to some extent the geology of the region, presents information obtained by me during the descent of the river with the Trimble party in 1921. The exploration of the canyon, which was financed jointly by the United States Geological Survey and the Southern California Edison Co., had as its primary object the mapping and study of the San Juan in connection with proposed power and storage projects along this and Colorado rivers.1 The exploration party was headed by K. W. Thimble, topographic engineer of the United States Geological Survey. Other members of the party were Robert N. Allen, Los Angeles, Calif., recorder; H. E. Blake, jr., Monticello, Utah, and Hugh Hyde, Salt Lake City, Utah, rodmen; Bert Loper, Green River, Utah, boatman; Heber Christensen, Moab, Utah, cook; and H. D. Miser, geologist. Wesley Oliver, of Mexican Hat, Utah, served as packer for the party and brought mail and provisions by pack train twice a month to specified accessible places west of Goodridge.

  12. Transport of surface waters from the Juan de Fuca eddy region to the Washington coast

    NASA Astrophysics Data System (ADS)

    MacFadyen, Amoreena; Hickey, Barbara M.; Foreman, Michael G. G.

    2005-10-01

    A seasonal cold eddy located off the mouth of the Strait of Juan de Fuca has been implicated as an initiation site for toxic HABs affecting the Washington coast. To investigate the fate of eddy waters, a diagnostic finite element circulation model was developed for this region and the northern Washington shelf. The model was based on hydrographic data from several cruises in the summer of 1998, a year in which record levels of toxin were measured in razor clams at Washington beaches. Additional model forcing included tides and surface wind stress typical of fair weather/upwelling conditions or fall storms. The model showed strong retention in the eddy and a preferred southeastward trajectory for model drifters leaving the eddy. ARGOS-tracked drifters released in the vicinity of the eddy in the summers of 2001 through 2003 were consistent with model results generated with 1998 data demonstrating the robust nature of the large-scale currents in this region. Model and true drifter results show that the Juan de Fuca eddy is an important source region for PNW shelf waters. Furthermore, both model and true drifters moved onshore during storms suggesting that surface waters of the Juan de Fuca eddy can impact the Washington coast.

  13. Oil-bearing sediments beneath San Juan volcanics - Colorado's newest frontier

    SciTech Connect

    Gries, R.R.

    1985-05-01

    During the Tertiary, the western part of the northern Sange de Cristo Range dropped 16,000 ft (4877 m) to become what is now known as the San Luis basin. The foreland basin formerly adjacent to and west of the range remained intact but was subsequently concealed by 10,000 ft (3048 m) of volcanic deposits. The existence of this concealed basin, a northeastern arm of the San Juan basin, was first suggested by Vincent Kelly who named it the San Juan sag. Oil, which was generated in the underlying Mancos Shale, migrated upward into vesicles and fractures in volcanic rocks. In at least two places, oil is currently seeping onto the volcanic surface or into overlying soil. These oil occurrences encouraged geologic and geophysical exploration and have led to confirmation by drilling that the basin exists. Porous reservoirs in both tertiary sedimentary rocks and volcanic rocks overlie a 2000 ft (610 m) Cretaceous Mancos Shale source rock. Within the Mancos Shale are fractured reservoirs, volcanic sills that have reservoir potential where fractured or porous, and stray sandstones. The Dakota Formation underlies the Mancos Shale and is about 200 ft (61 m) thick in this area. In addition, the Jurassic section has potential for source rocks in the Todilto Formation and reservoir rocks in the Entrada and Junction Creek Sandstones. The San Juan sag, a newly discovered basin of 2600 miS (6734 kmS) is a frontier for Colorado oil and gas exploration.

  14. Juan de Fuca slab geometry and its relation to Wadati-Benioff zone seismicity

    USGS Publications Warehouse

    McCrory, Patricia A.; Blair, J. Luke; Waldhause, Felix; Oppenheimer, David H.

    2012-01-01

    A new model of the subducted Juan de Fuca plate beneath western North America allows first-order correlations between the occurrence of Wadati-Benioff zone earthquakes and slab geometry, temperature, and hydration state. The geo-referenced 3D model, constructed from weighted control points, integrates depth information from earthquake locations and regional seismic velocity studies. We use the model to separate earthquakes that occur in the Cascadia forearc from those that occur within the underlying Juan de Fuca plate and thereby reveal previously obscured details regarding the spatial distribution of earthquakes. Seismicity within the slab is most prevalent where the slab is warped beneath northwestern California and western Washington suggesting that slab flexure, in addition to expected metamorphic dehydration processes, promotes earthquake occurrence within the subducted oceanic plate. Earthquake patterns beneath western Vancouver Island are consistent with slab dehydration processes. Conversely, the lack of slab earthquakes beneath western Oregon is consistent with an anhydrous slab. Double-differenced relocated seismicity resolves a double seismic zone within the slab beneath northwestern California that strongly constrains the location of the plate interface and delineates a cluster of seismicity 10 km above the surface that includes the 1992 M7.1 Mendocino earthquake. We infer that this earthquake ruptured a surface within the Cascadia accretionary margin above the Juan de Fuca plate. We further speculate that this earthquake is associated with a detached fragment of former Farallon plate. Other subsurface tectonic elements within the forearc may have the potential to generate similar damaging earthquakes.

  15. Carbon Isotopic tests on the Origins of the Shuram Anomaly from the San Juan Fm., Peru

    NASA Astrophysics Data System (ADS)

    Hodgin, E. B.

    2015-12-01

    Carbon isotope anomalies are associated with perturbations to the carbon cycle that offer insight into the geochemical evolution of the Earth. The largest Carbon isotope anomaly in earth history is the Shuram, which remains poorly understood in spite of being linked to the oxygenation of earth, the rise of metazoans, and a complete reorganization of the carbon cycle. From a basin transect of the carbonate-dominated San Juan Formation in southern Peru, we present evidence for the first clear example of the Shuram isotope anomaly in South America. Unique to this succession are ~140 meters of organic-rich black shale within the anomaly, containing as much as 4% TOC. Preliminary data from the organic-rich black shales of the San Juan Fm. confirm that δ13Corg is relatively invariant and does not covary with δ13Ccarb. These observations are consistent with other Shuram sections and support various models: an exogenous carbon source, an enlarged dissolved organic carbon pool, as well as authigenic carbonate production in organic-rich anoxic sediments. Critical tests of these models have been complicated by a paucity of organics in Shuram facies worldwide. Further analyses of the robust organics from the Shuram facies of the San Juan Fm. therefore hold promise in shedding light on the origin of the Shuram isotope anomaly and critical earth history events to which it has been linked.

  16. Assessing climate variability effects on dengue incidence in San Juan, Puerto Rico.

    PubMed

    Méndez-Lázaro, Pablo; Muller-Karger, Frank E; Otis, Daniel; McCarthy, Matthew J; Peña-Orellana, Marisol

    2014-09-11

    We test the hypothesis that climate and environmental conditions are becoming favorable for dengue transmission in San Juan, Puerto Rico. Sea Level Pressure (SLP), Mean Sea Level (MSL), Wind, Sea Surface Temperature (SST), Air Surface Temperature (AST), Rainfall, and confirmed dengue cases were analyzed. We evaluated the dengue incidence and environmental data with Principal Component Analysis, Pearson correlation coefficient, Mann-Kendall trend test and logistic regressions. Results indicated that dry days are increasing and wet days are decreasing. MSL is increasing, posing higher risk of dengue as the perimeter of the San Juan Bay estuary expands and shorelines move inland. Warming is evident with both SST and AST. Maximum and minimum air surface temperature extremes have increased. Between 1992 and 2011, dengue transmission increased by a factor of 3.4 (95% CI: 1.9-6.1) for each 1 °C increase in SST. For the period 2007-2011 alone, dengue incidence reached a factor of 5.2 (95% CI: 1.9-13.9) for each 1 °C increase in SST. Teenagers are consistently the age group that suffers the most infections in San Juan. Results help understand possible impacts of different climate change scenarios in planning for social adaptation and public health interventions.

  17. Contemporary geochemical composition and flux of aeolian dust to the San Juan Mountains, Colorado, United States

    NASA Astrophysics Data System (ADS)

    Lawrence, Corey R.; Painter, T. H.; Landry, C. C.; Neff, J. C.

    2010-09-01

    Dust deposition in the Rocky Mountains may be an important biogeochemical flux from upwind ecosystems. Seasonal (winter/spring) dust mass fluxes to the San Juan Mountains during the period from 2004 to 2008 ranged from 5 to 10 g m-2, with individual deposition events reaching as high as 2 g m-2. Dust deposited in the San Juan Mountains was primarily composed of silt- and clay-sized particles, indicating a regional source area. The concentrations of most major and minor elements in this dust were similar to or less than average upper continental crustal concentrations, whereas trace element concentrations were often enriched. In particular, dust collected from the San Juan Mountain snowpack was characterized by enrichments of heavy metals including As, Cu, Cd, Mo, Pb, and Zn. The mineral composition of dust partially explained dust geochemistry; however, based on results of a sequential leaching procedure it appeared that trace element enrichments were associated with the organic-, and not the mineral-, fraction of dust. Our observations show that the dust-derived fluxes of several nutrients and trace metals are substantial and, because many elements are deposited in a mobile form, could be important controls of vegetation, soil, or surface water chemistry. The flux measurements reported here are useful benchmarks for the characterization of ecosystem biogeochemical cycling in the Rocky Mountains.

  18. Sediment-bound trace metals in Golfe-Juan Bay, northwestern Mediterranean: Distribution, availability and toxicity.

    PubMed

    Tiquio, Ma Gregoria Joanne; Hurel, Charlotte; Marmier, Nicolas; Taneez, Mehwish; Andral, Bruno; Jordan, Norbert; Francour, Patrice

    2017-05-15

    The concentration, potential mobility, cation exchange capacity and toxicity of eight sediment-bound metals in Golfe-Juan Bay, France were examined. Results revealed significant spatial gradient of metal contamination along Golfe-Juan coast. The distribution and concentration of the metals appear to be influenced by the geochemical properties of the sediment, proximity to anthropogenic sources and general water circulation in the bay. The portion of trace metals found in the exchangeable, carbonate, oxidizable and reducible fractions of the sediment constitute 31%-58% of the total sediment-bound trace metal content, suggesting significant potential for remobilization of metals into the water column. Pb and Ni content of the sediment exceed the limits of the French marine sediment quality. Whole sediment extracts showed acute toxicity to marine rotifers. This study concludes that monitoring and management of sediment-bound trace metals in Golfe-Juan Bay are important so as not to underestimate their availability and risk to the marine ecosystems. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Geologic map of the central San Juan caldera cluster, southwestern Colorado

    USGS Publications Warehouse

    Lipman, Peter W.

    2006-01-01

    The San Juan Mountains are the largest erosional remnant of a composite volcanic field that covered much of the southern Rocky Mountains in middle Tertiary time. The San Juan field consists mainly of intermediate-composition lavas and breccias, erupted about 35-30 Ma from scattered central volcanoes (Conejos Formation) and overlain by voluminous ash-flow sheets erupted from caldera sources. In the central San Juan Mountains, eruption of at least 8,800 km3 of dacitic-rhyolitic magma as nine major ash flow sheets (individually 150-5,000 km3) was accompanied by recurrent caldera subsidence between 28.3 Ma and about 26.5 Ma. Voluminous andesitic-dacitic lavas and breccias erupted from central volcanoes prior to the ash-flow eruptions, and similar lava eruptions continued within and adjacent to the calderas during the period of more silicic explosive volcanism. Exposed calderas vary in size from 10 to 75 km in maximum dimension; the largest calderas are associated with the most voluminous eruptions.

  20. Explorer deformation zone: Evidence of a large shear zone and reorganization of the Pacific Juan de Fuca North American triple junction

    NASA Astrophysics Data System (ADS)

    Dziak, Robert P.

    2006-03-01

    Recently collected multibeam bathymetry and hydroacoustic earthquake data are used to investigate the recent tectonics of the Explorer Juan de Fuca Ridge systems, the boundaries between the Pacific and northern Juan de Fuca plates. The bathymetric and seismic evidence presented is consistent with a zone of shear extending well south of the Sovanco Fracture Zone to include the Heck and Heckle seamounts, and potentially as far south as the Springfield Seamounts and Cobb offset along the Juan de Fuca Ridge. This indicates that the triple junction between the Pacific Juan de Fuca North American plates may be reorganizing southward to establish at the Cobb offset.