Science.gov

Sample records for k-12 significantly alters

  1. Significant Bias against the ACA Triplet in the tmRNA Sequence of Escherichia coli K-12 ▿ †

    PubMed Central

    Baik, Sarah; Inoue, Koichi; Ouyang, Ming; Inouye, Masayori

    2009-01-01

    The toxin MazF in Escherichia coli cleaves single-stranded RNAs specifically at ACA sequences. MazF overexpression virtually eliminates all cellular mRNAs to completely block protein synthesis. However, protein synthesis can continue on an mRNA that is devoid of ACA triplets. The finding that ribosomal RNAs remain intact in the face of complete translation arrest suggested a purpose for such preservation. We therefore examined the sequences of all transcribed RNAs to determine if there was any statistically significant bias against ACA. While ACA motifs are absent from tmRNA, 4.5S RNA, and seven of the eight 5S rRNAs, statistical analysis revealed that only for tmRNA was the absence nonrandom. The introduction of single-strand ACAs makes tmRNA highly susceptible to MazF cleavage. Furthermore, analysis of tmRNA sequences from 442 bacteria showed that the discrimination against ACA in tmRNAs was seen mostly in enterobacteria. We propose that the unusual bias against ACA in tmRNA may have coevolved with the acquisition of MazF. PMID:19633073

  2. Spontaneous and UV-induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I

    SciTech Connect

    Bates, H.; Randall, S.K.; Rayssiguier, C.; Bridges, B.A.; Goodman, M.F.; Radman, M.

    1989-05-01

    The induction of mutations to valine resistance and to rifampin resistance occurs after UV irradiation in bacteria carrying a deletion through the polA gene (delta polA), showing that DNA polymerase I (PolI) is not an essential enzyme for this process. The PolI deletion strain showed a 7- to 10-fold-higher spontaneous mutation frequency than the wild type. The presence in the deletion strain of the 5'----3' exonuclease fragment on an F' episome caused an additional 10-fold increase in spontaneous mutation frequency, resulting in mutation frequencies on the order of 50- to 100-fold greater than wild type. The mutator effect associated with the 5'----3' exonuclease gene fragment together with much of the effect attributable to the polA deletion was blocked in bacteria carrying a umuC mutation. The mutator activity therefore appears to reflect constitutive SOS induction. Excision-proficient polA deletion strains exhibited increased sensitivity to the lethal effect of UV light which was only partially ameliorated by the presence of polA+ on an F' episome. The UV-induced mutation rate to rifampin resistance was marginally lower in delta polA bacteria than in bacteria carrying the polA+ allele. This effect is unlikely to be caused by the existence of a PolI-dependent mutagenic pathway and is probably an indirect effect caused by an alteration in the pattern of excision repair, since it did not occur in excision-deficient (uvrA) bacteria.

  3. K-12 Art Guide.

    ERIC Educational Resources Information Center

    Furney, Trudy; And Others

    The development of students in various art fields is the focus of this K-12 art curriculum guide. The philosophy of the art program and the roles of administrator, teacher, and parent are outlined. The underlying school community relationships, and the objective, goals, and purposes of art education are described. Phases of child development in…

  4. The LysR-type transcriptional regulator QseD alters type three secretion in enterohemorrhagic Escherichia coli and motility in K-12 Escherichia coli.

    PubMed

    Habdas, Benjamin J; Smart, Jennifer; Kaper, James B; Sperandio, Vanessa

    2010-07-01

    Enterohemorrhagic Escherichia coli (EHEC) O157:H7 responds to the host-produced epinephrine and norepinephrine, and bacterially produced autoinducer 3 (AI-3), through two-component systems. Further integration of multiple regulatory signaling networks, involving regulators such as the LysR-type transcriptional regulator (LTTR) QseA, promotes effective regulation of virulence factors. These include the production of flagella, a phage-encoded Shiga toxin, and genes within the locus of enterocyte effacement (LEE) responsible for attaching and effacing (AE) lesion formation. Here, we describe a new member of this signaling cascade, an LTTR heretofore renamed QseD (quorum-sensing E. coli regulator D). QseD is present in all enterobacteria but exists almost exclusively in O157:H7 isolates as a helix-turn-helix (HTH) truncated isoform. This "short" isoform (sQseD) is still able to regulate gene expression through a different mechanism than the full-length K-12 E. coli "long" QseD isoform (lQseD). The EHEC Delta qseD mutant exhibits increased expression of all LEE operons and deregulation of AE lesion formation. The loss of qseD in EHEC does not affect motility, but the K-12 Delta qseD mutant is hypermotile. While the lQseD directly binds to the ler promoter, encoding the LEE master regulator, to repress LEE transcription, the sQseD isoform does not. LTTRs bind to DNA as tetramers, and these data suggest that sQseD regulates ler by forming heterotetramers with another LTTR. The LTTRs known to regulate LEE transcription, QseA and LrhA, do not interact with sQseD, suggesting that sQseD acts as a dominant-negative partner with a yet-unidentified LTTR.

  5. Altered regulation of the OmpF porin by Fis in Escherichia coli during an evolution experiment and between B and K-12 strains.

    PubMed

    Crozat, Estelle; Hindré, Thomas; Kühn, Lauriane; Garin, Jérome; Lenski, Richard E; Schneider, Dominique

    2011-01-01

    The phenotypic plasticity of global regulatory networks provides bacteria with rapid acclimation to a wide range of environmental conditions, while genetic changes in those networks provide additional flexibility as bacteria evolve across long time scales. We previously identified mutations in the global regulator-encoding gene fis that enhanced organismal fitness during a long-term evolution experiment with Escherichia coli. To gain insight into the effects of these mutations, we produced two-dimensional protein gels with strains carrying different fis alleles, including a beneficial evolved allele and one with an in-frame deletion. We found that Fis controls the expression of the major porin-encoding gene ompF in the E. coli B-derived ancestral strain used in the evolution experiment, a relationship that has not been described before. We further showed that this regulatory connection evolved over two different time scales, perhaps explaining why it was not observed before. On the longer time scale, we showed that this regulation of ompF by Fis is absent from the more widely studied K-12 strain and thus is specific to the B strain. On a shorter time scale, this regulatory linkage was lost during 20,000 generations of experimental evolution of the B strain. Finally, we mapped the Fis binding sites in the ompF regulatory region, and we present a hypothetical model of ompF expression that includes its other known regulators.

  6. Quality Library Services, K-12.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus.

    Developed to promote excellence in Ohio's school libraries, this document is designed to: (1) provide a rationale for integration of the school library into the total education program; (2) delineate the dimensions of service of a dynamic K-12 library program; (3) identify essential components of an effective K-12 library program; (4) provide a…

  7. K-12 Aerospace Education Programs

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA, the United States Air Force Academy, the Air Force Space Command, the University of Colorado at Colorado Springs (UCCS), and the United States Space Foundation teamed to produce a dynamic and successful graduate course and in-service program for K-12 educators that has a positive impact on education trends across the nation. Since 1986, more than 10,000 educators from across the United States have participated in Space Discovery and Teaching with Space affecting nearly a million students in grades K-12. The programs are designed to prepare educators to use the excitement of space to motivate students in all curriculum subjects.

  8. Policy Shop Casts Long K-12 Shadow

    ERIC Educational Resources Information Center

    Ujifusa, Andrew

    2012-01-01

    In nearly 40 years of legislative advocacy, the American Legislative Exchange Council (ALEC)--a free-market, limited-government group now drawing intense scrutiny for its support of a controversial self-defense law--has had a significant influence on K-12 education through its model legislation and work with state lawmakers to promote such…

  9. Classifying K-12 Blended Learning

    ERIC Educational Resources Information Center

    Staker, Heather; Horn, Michael B.

    2012-01-01

    The growth of online learning in the K-12 sector is occurring both remotely through virtual schools and on campuses through blended learning. In emerging fields, definitions are important because they create a shared language that enables people to talk about the new phenomena. The blended-learning taxonomy and definitions presented in this paper…

  10. Social Studies Objectives, K-12.

    ERIC Educational Resources Information Center

    Dependents Schools (DOD), Washington, DC.

    Six objectives which form the framework of a K-12 social studies program of Department of Defense Dependents Schools are outlined. The objectives are to evaluate the relationship between human beings and their social, natural, and man-made environment; analyze the origins and interrelationships of beliefs, values, and behavior patterns; solve…

  11. California's Future: K-12 Education

    ERIC Educational Resources Information Center

    Hill, Laura; Gao, Niu; Warren, Paul

    2015-01-01

    California educates more than six million children in its K-12 public schools. More than half of these children are economically disadvantaged, and almost a quarter are not native English speakers (compared to less than one in ten nationwide). California is working to address these challenges, in part by adopting a new, simplified school finance…

  12. Digital Learning in California's K-12 Schools. Just the Facts

    ERIC Educational Resources Information Center

    Gao, Niu

    2015-01-01

    This fact page briefly discusses the following facts on digital learning in California's K-12: (1) As California implements new tests in its K-12 schools, technology infrastructure is a key concern; (2) Many districts are confident that they had enough bandwidth for online field tests; (3) Digital learning will require significantly greater…

  13. Optics education for K-12

    NASA Astrophysics Data System (ADS)

    Bilbro, James W.; Gaines Walker, Janice M.

    2000-06-01

    The SPIE Education Committee has developed an outreach program aimed at enhancing the dissemination of information about optics to children in kindergarten through the 12th grade (K-12). The main impetus behind the program was that more practicing optical scientists and engineers would be willing to give lectures and demonstrations aimed at inspiring the next generation about optics if material could be made easily available. Consequently, three instructional `outreach kits' were assembled to use in teaching optics to kids in exciting and fun ways. These kits were beta-tested over the last two years at six different U.S. regional sites. Each `outreach kit' contained: (1) a workbook on Optical Demonstrations on the Overhead Projector; (2) a Science and Math Experience Manual: Light, Color and Their Uses; (3) The Optics Discovery Classroom Kit; (4) a slide show; and (5) a video on careers in optics. The best tests were aimed at evaluating the practical ways of utilizing the kits, developing easy-to-follow instructions for guiding others in their use and providing suggestions on modifications, additions, and deletions to the kits. This paper discuses this outreach program and provides details relative to the kit's composition and future plans.

  14. Author Reply to K12 Inc. Response

    ERIC Educational Resources Information Center

    National Education Policy Center, 2012

    2012-01-01

    K12 Inc. enrolls more public school students than any other private education management organization in the U.S. Much has been written about K12 Inc. (referred to in this report simply as "K12") by financial analysts and investigative journalists because it is a large, publicly traded company and is the dominant player in the operation and…

  15. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization.

    PubMed

    Patras, Kathryn A; Wescombe, Philip A; Rösler, Berenice; Hale, John D; Tagg, John R; Doran, Kelly S

    2015-09-01

    Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted to the newborn, causing severe invasive disease. Current routine screening and antibiotic prophylaxis have fallen short of complete prevention of GBS transmission, and GBS remains a leading cause of neonatal infection. We have investigated the ability of Streptococcus salivarius, a predominant member of the native human oral microbiota, to control GBS colonization. Comparison of the antibacterial activities of multiple S. salivarius strains by use of a deferred-antagonism test showed that S. salivarius strain K12 exhibited the broadest spectrum of activity against GBS. K12 effectively inhibited all GBS strains tested, including disease-implicated isolates from newborns and colonizing isolates from the vaginal tract of pregnant women. Inhibition was dependent on the presence of megaplasmid pSsal-K12, which encodes the bacteriocins salivaricin A and salivaricin B; however, in coculture experiments, GBS growth was impeded by K12 independently of the megaplasmid. We also demonstrated that K12 adheres to and invades human vaginal epithelial cells at levels comparable to GBS. Inhibitory activity of K12 was examined in vivo using a mouse model of GBS vaginal colonization. Mice colonized with GBS were treated vaginally with K12. K12 administration significantly reduced GBS vaginal colonization in comparison to nontreated controls, and this effect was partially dependent on the K12 megaplasmid. Our results suggest that K12 may have potential as a preventative therapy to control GBS vaginal colonization and thereby prevent its transmission to the neonate during pregnancy.

  16. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization

    PubMed Central

    Patras, Kathryn A.; Wescombe, Philip A.; Rösler, Berenice; Hale, John D.; Tagg, John R.

    2015-01-01

    Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted to the newborn, causing severe invasive disease. Current routine screening and antibiotic prophylaxis have fallen short of complete prevention of GBS transmission, and GBS remains a leading cause of neonatal infection. We have investigated the ability of Streptococcus salivarius, a predominant member of the native human oral microbiota, to control GBS colonization. Comparison of the antibacterial activities of multiple S. salivarius strains by use of a deferred-antagonism test showed that S. salivarius strain K12 exhibited the broadest spectrum of activity against GBS. K12 effectively inhibited all GBS strains tested, including disease-implicated isolates from newborns and colonizing isolates from the vaginal tract of pregnant women. Inhibition was dependent on the presence of megaplasmid pSsal-K12, which encodes the bacteriocins salivaricin A and salivaricin B; however, in coculture experiments, GBS growth was impeded by K12 independently of the megaplasmid. We also demonstrated that K12 adheres to and invades human vaginal epithelial cells at levels comparable to GBS. Inhibitory activity of K12 was examined in vivo using a mouse model of GBS vaginal colonization. Mice colonized with GBS were treated vaginally with K12. K12 administration significantly reduced GBS vaginal colonization in comparison to nontreated controls, and this effect was partially dependent on the K12 megaplasmid. Our results suggest that K12 may have potential as a preventative therapy to control GBS vaginal colonization and thereby prevent its transmission to the neonate during pregnancy. PMID:26077762

  17. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization.

    PubMed

    Patras, Kathryn A; Wescombe, Philip A; Rösler, Berenice; Hale, John D; Tagg, John R; Doran, Kelly S

    2015-09-01

    Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted to the newborn, causing severe invasive disease. Current routine screening and antibiotic prophylaxis have fallen short of complete prevention of GBS transmission, and GBS remains a leading cause of neonatal infection. We have investigated the ability of Streptococcus salivarius, a predominant member of the native human oral microbiota, to control GBS colonization. Comparison of the antibacterial activities of multiple S. salivarius strains by use of a deferred-antagonism test showed that S. salivarius strain K12 exhibited the broadest spectrum of activity against GBS. K12 effectively inhibited all GBS strains tested, including disease-implicated isolates from newborns and colonizing isolates from the vaginal tract of pregnant women. Inhibition was dependent on the presence of megaplasmid pSsal-K12, which encodes the bacteriocins salivaricin A and salivaricin B; however, in coculture experiments, GBS growth was impeded by K12 independently of the megaplasmid. We also demonstrated that K12 adheres to and invades human vaginal epithelial cells at levels comparable to GBS. Inhibitory activity of K12 was examined in vivo using a mouse model of GBS vaginal colonization. Mice colonized with GBS were treated vaginally with K12. K12 administration significantly reduced GBS vaginal colonization in comparison to nontreated controls, and this effect was partially dependent on the K12 megaplasmid. Our results suggest that K12 may have potential as a preventative therapy to control GBS vaginal colonization and thereby prevent its transmission to the neonate during pregnancy. PMID:26077762

  18. NASA Lewis' IITA K-12 Program

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Lewis Research Center's Information Infrastructure Technology and Applications for Kindergarten to 12th Grade (IITA K-12) Program is designed to introduce into school systems computing and communications technology that benefits math and science studies. By incorporating this technology into K-12 curriculums, we hope to increase the proficiency and interest in math and science subjects by K-12 students so that they continue to study technical subjects after their high school careers are over.

  19. Designer Librarian: Embedded in K12 Online Learning

    ERIC Educational Resources Information Center

    Boyer, Brenda

    2015-01-01

    Over the past two decades, shifts in technology have altered the roles of school librarians in a multitude of ways. New rigorous standards, proliferation of devices, and steady growth of online and blended learning for the K12 market now demand librarians engage with learners in online environments. Taking an instructional design approach is the…

  20. K-12 Educational Outcomes of Immigrant Youth

    ERIC Educational Resources Information Center

    Crosnoe, Robert; Turley, Ruth N. Lopez

    2011-01-01

    The children from immigrant families in the United States make up a historically diverse population, and they are demonstrating just as much diversity in their experiences in the K-12 educational system. Robert Crosnoe and Ruth Lopez Turley summarize these K-12 patterns, paying special attention to differences in academic functioning across…

  1. K12 Online School Practice in China

    ERIC Educational Resources Information Center

    Chen, Li; Wang, Nan; Qiao, Ailing

    2009-01-01

    Purpose: The purpose of this paper is two fold. First, it presents the developmental stages and running modes of K12 Online Schools in China. Second, it illustrates online education practice, its current status, and the use of ICT in online schools. The experiences and lessons learned from the development of the K12 Online Schools are presented,…

  2. Standards for K-12 Engineering Education?

    ERIC Educational Resources Information Center

    National Academies Press, 2010

    2010-01-01

    The goal of this study was to assess the value and feasibility of developing and implementing content standards for engineering education at the K-12 level. Content standards have been developed for three disciplines in STEM education--science, technology, and mathematic--but not for engineering. To date, a small but growing number of K-12

  3. Nebraska Science Standards: Grades K-12

    ERIC Educational Resources Information Center

    Nebraska Department of Education, 2010

    2010-01-01

    This publication presents the Nebraska Science Standards for Grades K-12. The standards are presented according to the following grades: (1) Grades K-2; (2) Grades 3-5; (3) Grades 6-8; and (4) Grades 9-12.

  4. Prognostic significance of TP53 alterations in breast carcinoma.

    PubMed Central

    Andersen, T. I.; Holm, R.; Nesland, J. M.; Heimdal, K. R.; Ottestad, L.; Børresen, A. L.

    1993-01-01

    Constant denaturant gel electrophoresis (CDGE) was used to screen 179 breast carcinomas for mutations in the conserved regions of the TP53 gene (exons 5 through 8). Mutations were found in 35 of 163 primary tumours (21%) and in 5 of 16 metastases (31%) and resided predominantly in exon 7. The majority of the mutations were G:C-->A:T transitions. Immunohistochemistry demonstrated nuclear accumulation of p53 protein in 35 of 162 primary tumours (22%) and in four of 15 metastases (27%). TP53 mutation was strongly associated with nuclear accumulation of p53 protein. In total 42 of 163 primary tumours (26%) and 5 of 16 metastases (31%) were demonstrated to contain TP53 alterations (mutation and/or nuclear protein accumulation). TP53 alteration in primary tumour was significantly associated with the following parameters: positive node status, T status > 1, negative oestrogen receptor status, negative progesterone receptor status, presence of ERBB2 gene amplification, and invasive ductal histology. Furthermore, there were statistically significant associations, independent of other prognostic factors, between TP53 alterations in primary tumour and disease-free and overall survival. Images Figure 1 Figure 2 PMID:8102535

  5. Reading: Exceptional Child Education Curriculum K-12.

    ERIC Educational Resources Information Center

    Biddle, Candace Thornton; And Others

    This K-12 reading curriculum for exceptional child education is arranged in a format comparable to the general education curriculum, and is sequenced in the order in which most children learn. The curriculum begins with a list of 123 objectives of the reading program. The objectives cover the areas of perceptual skills, word attack, structural…

  6. Mathematics. Exceptional Child Education Curriculum K-12.

    ERIC Educational Resources Information Center

    Jordon, Thelma; And Others

    The mathematics curriculum provides a framework of instruction for exceptional child education in grades K-12. Content areas include: numeration, whole numbers, rational numbers, real/complex numbers, calculator literacy, measurement, geometry, statistics, functions/relations, computer literacy, and pre-algebra. The guide is organized by content…

  7. Music, K-12. Program of Studies.

    ERIC Educational Resources Information Center

    Fairfax County Schools, VA.

    This program of studies defines the K-12 instructional program in music developed by the Fairfax County Public Schools, Virginia. The guide contains a general rationale for teaching music, program flow chart, and descriptions of programs in general music, vocal music, and instrumental music. Each general program description includes requisites for…

  8. Legitimizing Community Engagement with K-12 Schools

    ERIC Educational Resources Information Center

    Furco, Andrew

    2013-01-01

    This article examines the issue of internal legitimization and its importance in securing high-quality community engagement in K-12 schools. Drawing on the literature from the fields of community engagement, school reform, school-university partnerships, and school-community partnerships, this article describes some of the prevailing challenges…

  9. What Matters to Career K-12 Educators

    ERIC Educational Resources Information Center

    Harris, Mary M.

    2014-01-01

    Case studies about issues arising from education policy were written between 2003 and 2011 by doctoral candidates in Curriculum and Instruction who were career K-12 educators. Literary analysis was employed in grouping 57 case studies, which described primarily situations that occurred in school districts in one large metropolitan area, by topic…

  10. Budget Pain Dampening K-12 Efforts

    ERIC Educational Resources Information Center

    McNeil, Michele

    2009-01-01

    Governors and state lawmakers are poised to kick off their toughest legislative sessions in years, with the hope of sparing K-12 education from deep budget cuts in the face of mounting deficits--a far cry from the more typical push for new policy initiatives and school programs. Simply holding the line may prove difficult. Together, 31 states face…

  11. K-12 Bolsters Ties to Engineering

    ERIC Educational Resources Information Center

    Robelen, Erik W.

    2013-01-01

    When science, technology, engineering and mathematics (STEM) education is discussed in the K-12 sphere, it often seems like shorthand for mathematics and science, with perhaps a nod to technology and even less, if any, real attention to engineering. But recent developments signal that the "e" in STEM may be gaining a firmer foothold at the…

  12. Greening a K-12 School System

    ERIC Educational Resources Information Center

    Frantz, Steve

    2010-01-01

    The author, who has retired as Scarsdale elementary principal, was asked by the superintendent Michael McGill if he was interested in leading Scarsdale's green initiative. Early on in Scarsdale, they referred to their work as the "green initiative." After agreeing to lead the initiative, he set out to learn more about greening at K-12 school…

  13. Alberta K-12 ESL Proficiency Benchmarks

    ERIC Educational Resources Information Center

    Salmon, Kathy; Ettrich, Mike

    2012-01-01

    The Alberta K-12 ESL Proficiency Benchmarks are organized by division: kindergarten, grades 1-3, grades 4-6, grades 7-9, and grades 10-12. They are descriptors of language proficiency in listening, speaking, reading, and writing. The descriptors are arranged in a continuum of seven language competences across five proficiency levels. Several…

  14. Earth Science Content Guidelines Grades K-12.

    ERIC Educational Resources Information Center

    American Geological Inst., Alexandria, VA.

    Teams of teachers, other science educators, and scientists selected from a national search for project writers have proposed using the following set of questions to guide the inclusion of earth science content into the kindergarten through grade 12 curriculum. The Essential Questions are organized in a K-12 sequence by six content areas: (1) Solid…

  15. Aerospace Education Curriculum Guide (K-12).

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City.

    GRADES OR AGES: K-12. SUBJECT MATTER: Aerospace education. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into two main sections, one each for primary and secondary levels. Each section is further subdivided into several parts. The guide is printed and staple bound with a paper cover. OBJECTIVES AND ACTIVITIES: Activities at each level…

  16. Development of K-12 Engineering Outreach Materials

    NASA Technical Reports Server (NTRS)

    Jordan, William

    2003-01-01

    Six modules were created that can be used in K-12 classes to introduce students to what engineers can do at NASA.The purpose of this project was to create outreach materials for the classroom. To make it appealing to students, many color NASA photographs are used to illustrate NASA applications.Student experiments are described that can be performed to illustrate topics.

  17. Candidates Are at Odds over K-12

    ERIC Educational Resources Information Center

    Klein, Alyson; Hoff, David J.

    2008-01-01

    The presumed November match-up produced by the long presidential-primary season offers contrasting approaches to K-12 policy, along with some common ground on the basics of the No Child Left Behind Act (NCLB). Senator John McCain of Arizona, the presumptive Republican nominee, and Senator Barack Obama of Illinois, his Democratic counterpart, both…

  18. State Electoral Victors Face K-12 Hurdles

    ERIC Educational Resources Information Center

    McNeil, Michele

    2008-01-01

    The new class of governors, state legislators, and chief state school officers elected last week will face formidable challenges in dealing with the squeeze the nation's sagging economy--and ballooning state budget deficits--is putting on K-12 education. In the November 4 elections, Democrats added one more governor's office--in Missouri--to their…

  19. Approaching K-12 Online Education in Pennsylvania

    ERIC Educational Resources Information Center

    Vadell, Kathryn

    2013-01-01

    The purpose of this study is to determine how K-12 schools are addressing the need to accommodate online learners in Pennsylvania. It is built upon a review of literature focusing on educational legislation, the personalization of online learning and online learning solutions. The study posed 21 questions utilizing a mixed methods approach to…

  20. Student Success in Online K-12 Education

    ERIC Educational Resources Information Center

    Ronsisvalle, Tammy; Watkins, Ryan

    2005-01-01

    While online education has made great strides in recent years to become an accepted component of higher education, with many colleges now offering accredited online degree programs, the current opportunities and challenges of online K-12 education are still awash in the turbulent waters of regional politics, temperamental technologies, changing…

  1. Digital Cameras in the K-12 Classroom.

    ERIC Educational Resources Information Center

    Clark, Kenneth; Hosticka, Alice; Bedell, Jacqueline

    This paper discusses the use of digital cameras in K-12 education. Examples are provided of the integration of the digital camera and visual images into: reading and writing; science, social studies, and mathematics; projects; scientific experiments; desktop publishing; visual arts; data analysis; computer literacy; classroom atmosphere; and…

  2. K12 Inc. Scraps India Outsourcing

    ERIC Educational Resources Information Center

    Trotter, Andrew

    2008-01-01

    A company that runs one of the nation's largest networks of online schools recently decided to discontinue a program that arranged for high school teachers in the United States to send their students' English essays to India for evaluations by reviewers there. The existence of the program by Herndon, Virginia-based K12 Inc. is an example of the…

  3. Serving K-12 Education with DWEL.

    ERIC Educational Resources Information Center

    Aivazian, Bryan I.; Geary, Edward; Khoo, Michael; Sumner, Tamara; Ireton, Shirley

    2003-01-01

    Explains the Digital Water Education Library (DWEL) project, a collection being built by and for practicing educators for K-12 education. Discusses the need for high quality digital resources and what is needed to use them effectively, including easy access, grade level differentiation, and integrating resources into the curricula. (LRW)

  4. Virtual K-12 Leadership: A Postmodern Paradigm

    ERIC Educational Resources Information Center

    Tucker, Tommy N.

    2014-01-01

    This phenomenological, mixed-method study compared and contrasted virtual K-12 school leadership with traditional face-to-face leadership. All 106 participants served for a minimum of two years in each setting. The study was conducted in two phases in order to reveal consensus and dissensus points of view. Conceptually, a postmodern framework was…

  5. Ballot Measures Reflect K-12 Funding Jitters

    ERIC Educational Resources Information Center

    Klein, Alyson

    2010-01-01

    In an election year dominated by the pitched battle for Congress and major governors' races, state ballot measures involving education are largely tied to a similar theme: the burden of funding K-12 programs when state finances are shaky. In some cases, initiatives, constitutional amendments, and other ballot measures seek to tap new sources of…

  6. Web Connects K-12 Students with Scientists

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2009-01-01

    This article reports that Derek Cummings and Justin Lessler, Johns Hopkins University epidemiologists, have come to the Johns Hopkins Center for Talented Youth (CTY) to give a live webinar on the spread of swine flu. This web-based audio and video presentation is one of many efforts by universities and science organizations to put K-12 students in…

  7. The K-12 Cybrary at Work

    ERIC Educational Resources Information Center

    Farmer, Lesley

    2005-01-01

    Now that "everything is on the Net," what are the roles of K-12 libraries and librarians in a digital-age learning environment? School library media specialists (SLMSs) work with classroom instructors and learners throughout the educational process: from curriculum development to unit/module/lesson plan development and delivery, integrating…

  8. K-12 Curriculum Guide for Environmental Education.

    ERIC Educational Resources Information Center

    Poudre School District R-1, Ft. Collins, CO.

    This guide to environmental and outdoor education is based on the principle that man will properly care for his world only if he both understands and appreciates it. Seventy-two multidisciplinary environmental themes are identified for instruction in grades K-12. Each theme is presented with behavioral objectives, key concepts, and both in school…

  9. Guidelines for Teaching Mathematics K-12.

    ERIC Educational Resources Information Center

    Flax, Rosabel; And Others

    This guide is intended to provide a basic outline for developing local mathematics programs. It was developed to give Kansas mathematics teachers from grades K-12 minimal sequential experiences in implementing the skills, values, and concepts of the mathematics program. The guide contains objectives, a checklist of topics appropriate for each…

  10. Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature

    PubMed Central

    Shirey, Michael J.; Kudlik, D'Anne E.; Huo, Bing-Xing; Greene, Stephanie E.; Drew, Patrick J.

    2015-01-01

    Changes in brain temperature can alter electrical properties of neurons and cause changes in behavior. However, it is not well understood how behaviors, like locomotion, or experimental manipulations, like anesthesia, alter brain temperature. We implanted thermocouples in sensorimotor cortex of mice to understand how cortical temperature was affected by locomotion, as well as by brief and prolonged anesthesia. Voluntary locomotion induced small (∼0.1°C) but reliable increases in cortical temperature that could be described using a linear convolution model. In contrast, brief (90-s) exposure to isoflurane anesthesia depressed cortical temperature by ∼2°C, which lasted for up to 30 min after the cessation of anesthesia. Cortical temperature decreases were not accompanied by a concomitant decrease in the γ-band local field potential power, multiunit firing rate, or locomotion behavior, which all returned to baseline within a few minutes after the cessation of anesthesia. In anesthetized animals where core body temperature was kept constant, cortical temperature was still >1°C lower than in the awake animal. Thermocouples implanted in the subcortex showed similar temperature changes under anesthesia, suggesting these responses occur throughout the brain. Two-photon microscopy of individual blood vessel dynamics following brief isoflurane exposure revealed a large increase in vessel diameter that ceased before the brain temperature significantly decreased, indicating cerebral heat loss was not due to increased cerebral blood vessel dilation. These data should be considered in experimental designs recording in anesthetized preparations, computational models relating temperature and neural activity, and awake-behaving methods that require brief anesthesia before experimental procedures. PMID:25972579

  11. Connecting with Teachers and Students through K-12 Outreach Activities

    NASA Astrophysics Data System (ADS)

    Chapman, Susan; Lindbo, David; Robinson, Clay

    2014-05-01

    The Soil Science Society of America has invested heavily in a significant outreach effort to reach teachers and students in the primary/secondary grades (K-12 grades in US/Canada) to raise awareness of soil as a critical resource. The SSSA K-12 committee has been charged with increasing interest and awareness of soil science as a scientific pursuit and career choice, and providing resources that integrate more information on soil science into biology, chemistry, physics, and earth science areas taught at multiple grade levels. Activities center around five main areas: assessment and standards, learning modules/lesson plans, website development, and books and materials, and partnership activities. Members (professionals and students) of SSSA are involved through committee participation, local events, materials review, and project development.

  12. The K-12 Educational Technology Value Chain: Apps for Kids, Tools for Teachers and Levers for Reform

    ERIC Educational Resources Information Center

    Pierce, Glenn L.; Cleary, Paul F.

    2016-01-01

    Historically implementing, maintaining and managing educational technology has been difficult for K-12 educational systems. Consequently, opportunities for significant advances in K-12 education have often gone unrealized. With the maturation of Internet delivered services along with K-12 institutional trends, educational technologies are poised…

  13. Engineering Education in K-12 Schools

    NASA Astrophysics Data System (ADS)

    Spence, Anne

    2013-03-01

    Engineers rely on physicists as well as other scientists and mathematicians to explain the world in which we live. Engineers take this knowledge of the world and use it to create the world that never was. The teaching of physics and other sciences as well as mathematics is critical to maintaining our national workforce. Science and mathematics education are inherently different, however, from engineering education. Engineering educators seek to enable students to develop the habits of mind critical for innovation. Through understanding of the engineering design process and how it differs from the scientific method, students can apply problem and project based learning to solve the challenges facing society today. In this talk, I will discuss the elements critical to a solid K-12 engineering education that integrates science and mathematics to solve challenges throughout the world.

  14. An Examination of Ideology among Selected K12 Christian School Superintendents

    ERIC Educational Resources Information Center

    Dolson, Jimmy L.

    2013-01-01

    This research project focused on explaining the decision making process of K12 Christian school superintendents whose schools belong to the Association of Christian Schools International (ACSI) organization. In spite of their similar religious and philosophical beliefs, ACSI K12 Christian school superintendents differed significantly in…

  15. Recognizing Warning Signs of K-12 Christian School Distress That Lead to School Closure

    ERIC Educational Resources Information Center

    Fellers, Ron

    2013-01-01

    The objective of this research was to identify statistically significant warning signs of K12 Christian school distress that can lead to school closure in the areas of leadership, homogeneity of vision and culture, finances, and competition, as described by Fitzpatrick (2002) and Nichols (2006). Twenty-four strong, declining, and closed K-12

  16. Scientific and Engineering Practices in K-12 Classrooms: Understanding "A Framework for K-12 Science Education"

    ERIC Educational Resources Information Center

    Bybee, Rodger W.

    2011-01-01

    In this article, the author presents the science and engineering practices from the recently released "A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas" (NRC 2011). The author recognizes the changes implied by the new framework, and that a new generation of science education standards will present new…

  17. Scientific and Engineering Practices in K-12 Classrooms: Understanding "A Framework for K-12 Science Education"

    ERIC Educational Resources Information Center

    Bybee, Rodger W.

    2011-01-01

    The author presents the science and engineering practices from the recently released "A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas." He recognizes the changes implied by the new framework, and eventually a new generation of science education standards will present new perspectives for the science…

  18. Scientific and Engineering Practices in K-12 Classrooms: Understanding "A Framework for K-12 Science Education"

    ERIC Educational Resources Information Center

    Bybee, Rodger W.

    2011-01-01

    In this article, the author presents the science and engineering practices from the recently released "A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas" (NRC 2011). The author recognizes the changes implied by the new framework, and eventually a new generation of science education standards will present new…

  19. K-12 educational outcomes of immigrant youth.

    PubMed

    Crosnoe, Robert; Turley, Ruth N López

    2011-01-01

    The children from immigrant families in the United States make up a historically diverse population, and they are demonstrating just as much diversity in their experiences in the K-12 educational system. Robert Crosnoe and Ruth López Turley summarize these K-12 patterns, paying special attention to differences in academic functioning across segments of the immigrant population defined by generational status, race and ethnicity, and national origin. A good deal of evidence points to an immigrant advantage in multiple indicators of academic progress, meaning that many youths from immigrant families outperform their peers in school. This apparent advantage is often referred to as the immigrant paradox, in that it occurs despite higher-than-average rates of social and economic disadvantages in this population as a whole. The immigrant paradox, however, is more pronounced among the children of Asian and African immigrants than other groups, and it is stronger for boys than for girls. Furthermore, evidence for the paradox is far more consistent in secondary school than in elementary school. Indeed, school readiness appears to be one area of potential risk for children from immigrant families, especially those of Mexican origin. For many groups, including those from Latin America, any evidence of the immigrant paradox usually emerges after researchers control for family socioeconomic circumstances and youths' English language skills. For others, including those from Asian countries, it is at least partially explained by the tendency for more socioeconomically advantaged residents of those regions to leave their home country for the United States. Bilingualism and strong family ties help to explain immigrant advantages in schooling; school, community, and other contextual disadvantages may suppress these advantages or lead to immigrant risks. Crosnoe and Turley also discuss several policy efforts targeting young people from immigrant families, especially those of Latin

  20. K-12 educational outcomes of immigrant youth.

    PubMed

    Crosnoe, Robert; Turley, Ruth N López

    2011-01-01

    The children from immigrant families in the United States make up a historically diverse population, and they are demonstrating just as much diversity in their experiences in the K-12 educational system. Robert Crosnoe and Ruth López Turley summarize these K-12 patterns, paying special attention to differences in academic functioning across segments of the immigrant population defined by generational status, race and ethnicity, and national origin. A good deal of evidence points to an immigrant advantage in multiple indicators of academic progress, meaning that many youths from immigrant families outperform their peers in school. This apparent advantage is often referred to as the immigrant paradox, in that it occurs despite higher-than-average rates of social and economic disadvantages in this population as a whole. The immigrant paradox, however, is more pronounced among the children of Asian and African immigrants than other groups, and it is stronger for boys than for girls. Furthermore, evidence for the paradox is far more consistent in secondary school than in elementary school. Indeed, school readiness appears to be one area of potential risk for children from immigrant families, especially those of Mexican origin. For many groups, including those from Latin America, any evidence of the immigrant paradox usually emerges after researchers control for family socioeconomic circumstances and youths' English language skills. For others, including those from Asian countries, it is at least partially explained by the tendency for more socioeconomically advantaged residents of those regions to leave their home country for the United States. Bilingualism and strong family ties help to explain immigrant advantages in schooling; school, community, and other contextual disadvantages may suppress these advantages or lead to immigrant risks. Crosnoe and Turley also discuss several policy efforts targeting young people from immigrant families, especially those of Latin

  1. Addition of Cryoprotectant Significantly Alters the Epididymal Sperm Proteome.

    PubMed

    Yoon, Sung-Jae; Rahman, Md Saidur; Kwon, Woo-Sung; Park, Yoo-Jin; Pang, Myung-Geol

    2016-01-01

    Although cryopreservation has been developed and optimized over the past decades, it causes various stresses, including cold shock, osmotic stress, and ice crystal formation, thereby reducing fertility. During cryopreservation, addition of cryoprotective agent (CPA) is crucial for protecting spermatozoa from freezing damage. However, the intrinsic toxicity and osmotic stress induced by CPA cause damage to spermatozoa. To identify the effects of CPA addition during cryopreservation, we assessed the motility (%), motion kinematics, capacitation status, and viability of epididymal spermatozoa using computer-assisted sperm analysis and Hoechst 33258/chlortetracycline fluorescence staining. Moreover, the effects of CPA addition were also demonstrated at the proteome level using two-dimensional electrophoresis. Our results demonstrated that CPA addition significantly reduced sperm motility (%), curvilinear velocity, viability (%), and non-capacitated spermatozoa, whereas straightness and acrosome-reacted spermatozoa increased significantly (p < 0.05). Ten proteins were differentially expressed (two decreased and eight increased) (>3 fold, p < 0.05) after CPA, whereas NADH dehydrogenase flavoprotein 2, f-actin-capping protein subunit beta, superoxide dismutase 2, and outer dense fiber protein 2 were associated with several important signaling pathways (p < 0.05). The present study provides a mechanistic basis for specific cryostresses and potential markers of CPA-induced stress. Therefore, these might provide information about the development of safe biomaterials for cryopreservation and basic ground for sperm cryopreservation. PMID:27031703

  2. Addition of Cryoprotectant Significantly Alters the Epididymal Sperm Proteome

    PubMed Central

    Yoon, Sung-Jae; Rahman, Md Saidur; Kwon, Woo-Sung; Park, Yoo-Jin; Pang, Myung-Geol

    2016-01-01

    Although cryopreservation has been developed and optimized over the past decades, it causes various stresses, including cold shock, osmotic stress, and ice crystal formation, thereby reducing fertility. During cryopreservation, addition of cryoprotective agent (CPA) is crucial for protecting spermatozoa from freezing damage. However, the intrinsic toxicity and osmotic stress induced by CPA cause damage to spermatozoa. To identify the effects of CPA addition during cryopreservation, we assessed the motility (%), motion kinematics, capacitation status, and viability of epididymal spermatozoa using computer-assisted sperm analysis and Hoechst 33258/chlortetracycline fluorescence staining. Moreover, the effects of CPA addition were also demonstrated at the proteome level using two-dimensional electrophoresis. Our results demonstrated that CPA addition significantly reduced sperm motility (%), curvilinear velocity, viability (%), and non-capacitated spermatozoa, whereas straightness and acrosome-reacted spermatozoa increased significantly (p < 0.05). Ten proteins were differentially expressed (two decreased and eight increased) (>3 fold, p < 0.05) after CPA, whereas NADH dehydrogenase flavoprotein 2, f-actin-capping protein subunit beta, superoxide dismutase 2, and outer dense fiber protein 2 were associated with several important signaling pathways (p < 0.05). The present study provides a mechanistic basis for specific cryostresses and potential markers of CPA-induced stress. Therefore, these might provide information about the development of safe biomaterials for cryopreservation and basic ground for sperm cryopreservation. PMID:27031703

  3. State of the Nation: K-12 Online Learning in Canada

    ERIC Educational Resources Information Center

    Barbour, Michael K.

    2009-01-01

    The goal of the initial "Snapshot State of the Nation: K-12 Online Learning in Canada" report was to provide an overview of the state of K-12 online learning in Canada. This was accomplished through the use of short commentaries about the state of K-12 distance education for each province and territory, along with more developed case studies for…

  4. Japanese Education in Grades K-12. ERIC Digest.

    ERIC Educational Resources Information Center

    Ellington, Lucien

    Japan's educational system, in particular its K-12 schools, remains one of the very best in the world. This digest provides an overview of the following topics: (1) Japanese educational achievements; (2) the structure of K-12 education in Japan; (3) the K-12 curriculum, with an emphasis on social studies education; (4) educational reform in Japan;…

  5. NASA-OAI HPCCP K-12 Program

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The NASA-OAI High Performance Communication and Computing K- 12 School Partnership program has been completed. Cleveland School of the Arts, Empire Computech Center, Grafton Local Schools and the Bug O Nay Ge Shig School have all received network equipment and connections. Each school is working toward integrating computer and communications technology into their classroom curriculum. Cleveland School of the Arts students are creating computer software. Empire Computech Center is a magnet school for technology education at the elementary school level. Grafton Local schools is located in a rural community and is using communications technology to bring to their students some of the same benefits students from suburban and urban areas receive. The Bug O Nay Ge Shig School is located on an Indian Reservation in Cass Lake, MN. The students at this school are using the computer to help them with geological studies. A grant has been issued to the friends of the Nashville Library. Nashville is a small township in Holmes County, Ohio. A community organization has been formed to turn their library into a state of the art Media Center. Their goal is to have a place where rural students can learn about different career options and how to go about pursuing those careers. Taylor High School in Cincinnati, Ohio was added to the schools involved in the Wind Tunnel Project. A mini grant has been awarded to Taylor High School for computer equipment. The computer equipment is utilized in the school's geometry class to computationally design objects which will be tested for their aerodynamic properties in the Barberton Wind Tunnel. The students who create the models can view the test in the wind tunnel via desk top conferencing. Two teachers received stipends for helping with the Regional Summer Computer Workshop. Both teachers were brought in to teach a session within the workshop. They were selected to teach the session based on their expertise in particular software applications.

  6. UPSeis - Visiting Seismographs for K-12 Schools

    NASA Astrophysics Data System (ADS)

    Wagner, S. R.; Len, S.; Pennington, W. D.

    2004-12-01

    Upper Peninsula Seismic Experiments in Schools (UPSeis) is an educational program developed to engage K-12 students in hands-on activities learning about earthquakes and Earth science. The system is intended to enhance teaching earth sciences to students, typically using teleseismic and regional earthquakes recorded directly in the classroom. This seismograph is computer-based and self-contained, requiring no hook-ups to the Internet or to advanced timing devices. It is easy to operate and relatively inexpensive to purchase. The UPSeis curriculum is designed so that a seismograph operates in a classroom for two or three months at a time, allowing the recording of at least 2 to 3 very large earthquakes somewhere in the world. The system comes with classroom activities, which are broken into several units, such as 'Seismic Waves', 'The UPSeis Technique' and 'Earthquake Hazards'. Within each unit, activities are rated for the appropriate grade level. All of the units have also been correlated to the Michigan Content Standards, and are easily adaptable to other state educational content standards as well. Our intention is to assist teachers and volunteers with bringing earth science into the classroom, by making it easier to obtain and operate seismographs. Ideally, a sponsor (University or Company) will pay for a system and any related costs. We further plan to train volunteers at conferences and meetings (such as AGU or SEG) in order to train them on a system and provide them with the knowledge required to assist teachers in the classroom. The volunteer would be available to come into the school and work with the teacher and students on some of the activities, particularly after they have recorded an earthquake. In addition, the volunteer would rotate their system between local area schools every 2 or 3 months. This allows teachers to use the system for a few months without the concern for maintenance of a permanent system. For schools interested in having a

  7. K-12 Online Teacher Beliefs: Relationships among Intelligence, Confidence, Teacher-Student Interactions, and Student Outcomes

    ERIC Educational Resources Information Center

    Vander Ploeg, Guadalupe

    2012-01-01

    The vigorous expansion of online learning in K-12 education is a recent change to the conceptualization of schooling that has been occurring for more than 10 years. However, methods used for recruiting, hiring, and preparing online teachers have not been altered beyond the current federal standard defined by No Child Left Behind of Highly…

  8. K-12 science education: A teacher`s view

    SciTech Connect

    Moore, P.

    1994-12-31

    Science education has experienced significant changes over the past two decades. Science is now vital to good citizenship, performance in the workplace, and everyday life.It is time to re-tool and re-design the entire K-12 science education system, employing the same principles and methods used in the practice of science itself. We can no longer ignore the special needs of science instruction. All students need a course that develops their scientific literacy and critical thinking skills every year. Each science program needs meaningful, useful content and skill standards to drive and continuously update the curriculum content and enabel usefull assessment. Science teachers must articulate their needs and develop opportunities for professional development and the strengthening of their profession. We need a national plan that gets the many different participants working coherently towards a common goal.

  9. Laboratory Safety Guide for Arkansas K-12 Schools.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    This document presents laboratory safety rules for Arkansas K-12 schools which were developed by the Arkansas Science Teachers Association (ASTA) and the Arkansas Department of Education (ADE). Contents include: (1) "Laboratory Safety Guide for Arkansas K-12 Schools"; (2) "Safety Considerations"; (3) "Safety Standards for Science Laboratories";…

  10. Influences of Globalization on K-12 Language Teacher Education Programs

    ERIC Educational Resources Information Center

    Singh, Navin Kumar

    2012-01-01

    The purpose of this study was to explore the effects of globalization on K-12 language teacher education at Northern Arizona University (NAU) in terms of multilingual practices in the US, with reference to an English-only-state, Arizona. This study explored influences of globalization on K-12 language education practices in the US through teacher…

  11. A Critique of the Brave New World of K-12

    ERIC Educational Resources Information Center

    Salmani-Nodoushan, Mohammad Ali

    2008-01-01

    Over the past few decades has changed so rapidly that remote areas of the Earth are now inhabited by human beings. Technology has also developed and people can stay at home and have access to virtual schools. This has stimulated the need for K-12 education. K-12 education has emerged from the no-child-left-behind concerns of governments for…

  12. State of the Nation: K-12 Online Learning in Canada

    ERIC Educational Resources Information Center

    Barbour, Michael K.

    2010-01-01

    Two years ago, the then North American Council for Online Learning released the initial "Snapshot State of the Nation: K-12 Online Learning in Canada" report. This study was the first systematic examination of K-12 distance education policies and activities in each of the thirteen Canadian provinces and territories. One year ago, the International…

  13. Formulating Independent School K-12 Quality Physical Education Program Guidelines

    ERIC Educational Resources Information Center

    Currie, Stuart M.; Phillips, Michael B.; Jubenville, Colby B.

    2012-01-01

    The purpose of this study was to formulate Tennessee independent school K-12 quality physical education program guidelines. A panel of 18 physical education representatives from Tennessee independent schools K-12 participated in a three-phase Delphi study and completed three opinionnaires via e-mail. In Phase One, Opinionnaire One solicited panel…

  14. Developing Open Education Literacies with Practicing K-12 Teachers

    ERIC Educational Resources Information Center

    Kimmons, Royce M.

    2014-01-01

    This study seeks to understand how to use formal learning activities to effectively support the development of open education literacies among K-12 teachers. Considering pre-and post-surveys from K-12 teachers (n = 80) who participated in a three-day institute, this study considers whether participants entered institutes with false confidence or…

  15. Revolutionizing Arts Education in K-12 Classrooms through Technological Integration

    ERIC Educational Resources Information Center

    Lemon, Narelle, Ed.

    2015-01-01

    Educational technologies are becoming more commonplace across the K-12 curriculum. In particular, the use of innovative digital technology is expanding the potential of arts education, presenting new opportunities--and challenges--to both curricular design and pedagogical practice. "Revolutionizing Arts Education in K-12 Classrooms through…

  16. Test Of Astronomy STandards TOAST Survey of K-12 Teachers

    NASA Astrophysics Data System (ADS)

    Slater, Timothy F.; Slater, Stephanie; Stork, Debra J.

    2015-01-01

    Discipline-based education research in astronomy is focused on understanding the underlying mental mechanisms used by students when learning astronomy and teachers when teaching astronomy. Systematic surveys of K-12 teacher' knowledge in the domain of astronomy are conducted periodically in order to better focus and improve professional development. These surveys are most often done when doing contemporary needs assessments or when new assessment instruments are readily available. Designed by Stephanie J. Slater of the CAPER Center for Astronomy & Physics Education Research, the 29-item multiple-choice format Test Of Astronomy STandards - TOAST is a carefully constructed, criterion-referenced instrument constructed upon a solid list of clearly articulated and widely agreed upon learning objectives. The targeted learning concepts tightly align with the consensus learning goals stated by the American Astronomical Society - Chair's Conference on ASTRO 101, the American Association of the Advancement of Science's Project 2061 Benchmarks, and the National Research Council's 1996 National Science Education Standards. Without modification, the TOAST is also aligned with the significantly less ambitious 2013 Next Generation Science Standards created by Achieve, Inc., under the auspices of the National Research Council. This latest survey reveals that K-12 teachers still hold many of the same fundamental misconceptions uncovered by earlier surveys. This includes misconceptions about the size, scale, and structure of the cosmos as well as misconceptions about the nature of physical processes at work in astronomy. This suggests that professional development in astronomy is still needed and that modern curriculum materials are best served if they provide substantial support for implementation.

  17. Missouri K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 19

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2014-01-01

    The "Missouri K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Missouri registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels…

  18. Minnesota K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 23

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2015-01-01

    The "Minnesota K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Minnesota registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response…

  19. Oklahoma K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 18

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2014-01-01

    The "Oklahoma K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Oklahoma registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels…

  20. Delaware K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 21

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2014-01-01

    The "Delaware K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Delaware registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels…

  1. Nevada K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 22

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2015-01-01

    The "Nevada K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Nevada registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and…

  2. Maine K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 12

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2013-01-01

    The "Maine K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Maine registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and differences…

  3. North Dakota K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 13

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2013-01-01

    The "North Dakota K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures North Dakota registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and…

  4. Texas K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 14

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2013-01-01

    The "Texas K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Texas registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and differences of…

  5. Louisiana K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 7

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    The "Louisiana K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Louisiana registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. In this paper the author and his colleagues report…

  6. Alaska K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 3

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2011-01-01

    The "Alaska K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Alaska registered voters' familiarity and views on a range of K-12 education issues and school choice reforms. The author and his colleagues report response levels and…

  7. Tennessee K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 9

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    The "Tennessee K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research Inc. (BRI), measures Tennessee registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and…

  8. Washington K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 6

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    The "Washington K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Washington registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response "levels"…

  9. Montana K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 10

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    The "Montana K-12 & School Choice Survey" project, commissioned by the Friedman Foundation for Educational Choice and conducted by Braun Research, Inc. (BRI), measures Montana registered voters' familiarity and views on a range of K-12 education topics and school choice reforms. The author and his colleagues report response levels and differences…

  10. New Mexico K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 4

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2011-01-01

    The "New Mexico K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures New Mexico voters' familiarity and views on a range of K-12 education issues and school choice reforms. The author and his colleagues report response "levels" and…

  11. Idaho K-12 & School Choice Survey: What Do Voters Say about K-12 Education. Polling Paper No. 5

    ERIC Educational Resources Information Center

    DiPerna, Paul

    2012-01-01

    The "Idaho K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Idaho registered voters' familiarity and views on a range of K-12 education issues and school choice reforms. We report response "levels" and "differences" (we use the term…

  12. Outstanding Science Trade Books for Students K-12.

    ERIC Educational Resources Information Center

    Science Teacher, 2003

    2003-01-01

    Presents outstanding science trade books published in 2002 for students in grades K-12. Sections include Archaeology, Anthropology, and Paleontology; Biography; Environment and Ecology; Life Science; Physical Science; and Science-Related Careers. (KHR)

  13. Outreach to Space Scientists Interested in K-12 Education

    NASA Technical Reports Server (NTRS)

    Morrow, Cherilynn A

    1998-01-01

    This is the final report for work on outreach to space scientists interested in k-12 education. It outlines what was accomplished during the two years of support and one year no-cost extension (October 1995-September 1998).

  14. A Vision in Aeronautics: The K-12 Wind Tunnel Project

    NASA Technical Reports Server (NTRS)

    1997-01-01

    A Vision in Aeronautics, a project within the NASA Lewis Research Center's Information Infrastructure Technologies and Applications (IITA) K-12 Program, employs small-scale, subsonic wind tunnels to inspire students to explore the world of aeronautics and computers. Recently, two educational K-12 wind tunnels were built in the Cleveland area. During the 1995-1996 school year, preliminary testing occurred in both tunnels.

  15. K-12 Phenology Lessons for the Phenocam Project

    NASA Astrophysics Data System (ADS)

    Bennett, K. F.

    2013-12-01

    Phenology is defined as periodic [or annual] life cycles of plants and animals driven by seasonal environmental changes. Climate change impinges a strong effect on phenology, potentially altering the structure and functioning of ecosystems. In the fall of 2011, the Ashburnham-Westminster Regional School District became the first of five schools to join Harvard University's Phenocam Network with the installation of a webcam to monitor phenology (or 'phenocam') at Overlook Middle School in Ashburnham, Massachusetts. Our school district is now part of a network of near-surface remote sensing phenocams that capture and send images of forest, shrub, and grassland vegetation cover at more than 130 diverse sites in North America. Our phenocam provides a digital image every half hour of the mixed forest canopy north from the school, enabling the detection of changes in canopy development, quantified as canopy 'greenness'. As a part of the Phenocam project, students at the K-12 level have expanded the scope of phenological monitoring protocol that is part of the Harvard Forest Schoolyard Ecology Program, Buds, Leaves, and Global Warming. In this protocol, students work with ecologists at Harvard Forest to monitor buds and leaves on schoolyard trees to determine the length of the growing season, giving them the opportunity to be a part of real and important research concerning the critical environmental issue of climate change. Students involved in the Buds, Leaves, and Global Warming study have the opportunity to compare their ground data on budburst, color change, and leaf drop to the phenocam images, as well as to similar forested sites in locations throughout the United States. Lessons have been developed for comparing student data to phenocam images, canopy greenness time series graphs extracted from the images, and satellite data. Lessons addressing map scale and the Urban Heat Island effect will also be available for teachers. This project will greatly enhance the

  16. Outsider to insider: resetting the natural host niche of commensal E. coli K-12.

    PubMed

    Sahu, Upasana; Kar, Sudeshna

    2012-01-01

    The status of E. coli K-12 as an exclusively non-invasive, non-pathogenic bacterium has almost been incontrovertible. Our recent finding that a mutation in one of its main architectural protein, HU, converts E. coli K-12 to an actively invasive form suggests that gaining host cell entry might be an expedient survival tactic for traditional commensals during certain altered host conditions. The mutant E. coli (SK3842) exhibits properties usually associated with pathogenic bacteria: host cell invasion, phagosomal disruption and intracellular replication. However, unlike the situation with some pathogens, internalized SK3842 imparts anti-apoptotic and cyto-protective effects rather than lethality on the host cell, both in vitro and in vivo. Here, we show that SK3842 also provides colonization resistance against other invasive pathogens--a trait not shared by the parental commensal strain. Thus, the altered lifestyle of SK3842 encompasses characteristics both from traditional pathogens as well as beneficial probiotic strains.

  17. Perspectives and Visions of Computer Science Education in Primary and Secondary (K-12) Schools

    ERIC Educational Resources Information Center

    Hubwieser, Peter; Armoni, Michal; Giannakos, Michail N.; Mittermeir, Roland T.

    2014-01-01

    In view of the recent developments in many countries, for example, in the USA and in the UK, it appears that computer science education (CSE) in primary or secondary schools (K-12) has reached a significant turning point, shifting its focus from ICT-oriented to rigorous computer science concepts. The goal of this special issue is to offer a…

  18. Perceptions of Professional and Educational Skills Learning Opportunities Made Available through K-12 Robotics Programming

    ERIC Educational Resources Information Center

    Bakke, Christine K.

    2013-01-01

    The purpose of this study is to examine whether participation in robotics provides opportunities for educational and professional skill development, significant enough to merit the recommendation of robotics courses as a part of mainstream curriculum offerings in K-12 schools. This non-experimental, mixed methods study examined current junior high…

  19. Algebra Project DR K-12 Cohorts--Demonstration Project: Summative Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark

    2014-01-01

    The Algebra Project DR K-12, funded by the National Science Foundation as a Research and Development Project, addressed the challenge of offering significant STEM content for students to ensure public literacy and workforce readiness. The project's primary purpose was to test the feasibility and effectiveness of a model for establishing four-year…

  20. Language Arts: Exceptional Child Education Curriculum K-12.

    ERIC Educational Resources Information Center

    Curran, Teresa; And Others

    The Exceptional Child Education (ECE) program of Jefferson County Public Schools in Louisville, Kentucky, presents this language arts curriculum for use with K-12 students who have learning problems. The ECE program uses the curriculum and materials of the general education program whenever appropriate, but has access to special instructional…

  1. Transforming K-12 Rural Education through Blended Learning: Teacher Perspectives

    ERIC Educational Resources Information Center

    Kellerer, Paula; Kellerer, Eric; Werth, Eric; Werth, Lori; Montgomery, Danielle; Clyde, Rozella; Cozart, Joe; Creach, Laura; Hibbard, Laura; LaFrance, Jason; Rupp, Nadine; Walker, Niki; Carter, Theresa; Kennedy, Kathryn

    2014-01-01

    A qualitative study exploring rural teacher perspectives on the impact of blended learning on students and teachers was conducted in Idaho during the Fall of 2013. Researchers from Northwest Nazarene University's DOCEO Center in partnership with Idaho Digital Learning Academy (IDLA) and the International Association for K-12 Online Learning…

  2. Unified Science Approach K-12, Proficiency Levels 1-6.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented are first-revision materials of the K-12 unified science program implemented in the public schools of Anne Arundel County, Maryland. Detailed descriptions are given of the roles of students and teachers, purposes of bibliography, major concepts in unified science, processes of inquiry, scheme and model for scientific literacy, and…

  3. The Condition of K-12 Public Education in Maine: 2005

    ERIC Educational Resources Information Center

    Gravelle, Paula B.; Silvernail, David L.

    2005-01-01

    This ninth edition of "The Condition of K-12 Public Education in Maine" is designed to provide Maine citizens, legislators, and educators a yearly report on the state of Maine public schools and education. This new edition updates educational information which appeared in earlier editions, and also provides information on several new topics.…

  4. The Condition of K-12 Public Education in Maine, 2004

    ERIC Educational Resources Information Center

    Gravelle, Paula B.; Silvernail, David L.

    2004-01-01

    This eighth edition of "The Condition of K-12 Public Education in Maine" is designed to provide Maine citizens, legislators, and educators a yearly report on the state of Maine public schools and education. This new edition updates educational information which appeared in earlier editions, and also provides information on several new topics.…

  5. The Condition of K-12 Public Education in Maine: 2006

    ERIC Educational Resources Information Center

    Gravelle, Paula B.; Silvernail, David L.

    2006-01-01

    This tenth edition of "The Condition of K-12 Public Education in Maine" is designed to provide Maine citizens, legislators, and educators a yearly report on the state of Maine public schools and education. This new edition updates educational information which appeared in earlier editions, and also provides information on several new topics.…

  6. The Condition of K-12 Public Education in Maine: 2009

    ERIC Educational Resources Information Center

    Donis-Keller, Christine; Silvernail, David L.

    2009-01-01

    This twelfth edition of "The Condition of K-12 Public Education in Maine" is designed to provide Maine citizens, legislators, and educators a yearly report on the state of Maine public schools and education. This new edition updates educational information which appeared in earlier editions, and also provides information on several new topics.…

  7. Teachers' Curriculum Guide to the Hayward Shoreline, K-12.

    ERIC Educational Resources Information Center

    Bachle, Leo; And Others

    This teaching guide gives environmental education ideas for grades K-12. The field trips and activities all relate to the Hayward shoreline of the San Francisco, California, Bay. Included in the guide are 44 science activities, 15 social science activities, and 18 humanities activities. Each activity description gives the experience level, site…

  8. Online System Adoption and K-12 Academic Outcomes

    ERIC Educational Resources Information Center

    Kimmons, R.

    2015-01-01

    This study seeks to understand the relationship between K-12 online system adoption (e.g., Blackboard, Edmodo, WordPress) and school-level academic achievement ratings. Utilizing a novel approach to data collection via website data extraction and indexing of all school websites in a target state in the United States (n?=?732) and merging these…

  9. Gender Sorting across K-12 Schools in the United States

    ERIC Educational Resources Information Center

    Long, Mark C.; Conger, Dylan

    2013-01-01

    This article documents evidence of nonrandom gender sorting across K-12 schools in the United States. The sorting exists among coed schools and at all grade levels, and it is highest in the secondary school grades. We observe some gender sorting across school sectors and types: for instance, males are slightly underrepresented in private schools…

  10. Exploring the Effectiveness of Online Education in K-12 Environments

    ERIC Educational Resources Information Center

    Heafner, Tina L., Ed.; Hartshorne, Richard, Ed.; Petty, Teresa, Ed.

    2015-01-01

    The integration of technology in classrooms is rapidly emerging as a way to provide more educational opportunities for students. As virtual learning environments become more popular, evaluating the impact of this technology on student success is vital. "Exploring the Effectiveness of Online Education in K-12 Environments" combines…

  11. Engaging K-12 Language Learners in Media Literacy

    ERIC Educational Resources Information Center

    Egbert, Joy; Neville, Chon

    2015-01-01

    Calls to integrate media literacy into K-12 language classrooms appear to have gone largely unheeded. However, media literacy skills are seen as crucial for 21st-century learners. This article answers the calls for a focus on media literacy in the language classroom by addressing both why and how systematic attention might be brought to this issue…

  12. Leadership Analysis in K-12 Case Study: "Divided Loyalties"

    ERIC Educational Resources Information Center

    Alsubaie, Merfat Ayesh

    2016-01-01

    This report mainly aims to provide a critical and in-depth analysis of the K-12 Case, "Divided Loyalty" by Holy and Tartar (2004). The case recounts how the manifestation of inadequate leadership skills in a school setting could affect negatively the performance of students.

  13. Demographics and Preparation Levels of K-12 Online Teachers

    ERIC Educational Resources Information Center

    Larson, Jean Sutton

    2014-01-01

    This study collected and examined information on K-12 teachers currently involved in online education in the United States. The purposes of this study included defining the demographics of these teachers, determining the extent to which they were formally educated and/or trained to teach online, and to compare these findings to those from a…

  14. Using Cue Cards throughout the K-12 Curriculum

    ERIC Educational Resources Information Center

    Conderman, Greg; Hedin, Laura R.

    2015-01-01

    As a flexible instructional tool, cue cards offer support for students with and without disabilities. By providing different amounts of support, they also can be used to differentiate instruction in a variety of subject areas and grade levels. This article describes various strategies for using cue cards and includes examples from K-12 classrooms.

  15. Assistive Devices. Exceptional Child Education, Curriculum K-12.

    ERIC Educational Resources Information Center

    Jefferson County Public Schools, Louisville, KY.

    The purpose of the Jefferson County (Kentucky) Public Schools K-12 Exceptional Child Education Curriculum is to facilitate teaching, and thereby learning, by providing a foundation of information and skills to be presented. The Assistive Devices curriculum is designed to help exceptional students learn to use specialized equipment. Assistive…

  16. Best Practices in Administration of K-12 Dance Programs

    ERIC Educational Resources Information Center

    Henneman, Suzanne E.

    2013-01-01

    The role of administering K-12 dance education programs is both exciting and invigorating. Being part of the decision-making process, problem solving with teams of colleagues, establishing routines and initiatives, creating "something from nothing," and watching programs grow is appealing to dance teachers as creative and critical…

  17. Supporting the K-12 Classroom through University Outreach

    ERIC Educational Resources Information Center

    Moskal, Barbara; Skokan, Catherine

    2011-01-01

    This article provides a field-based example of a series of outreach programs that have been designed in response to current recommendations found in the K-12 outreach literature. These programs begin with university mathematics and science faculty members teaching a 10-day summer workshop to elementary and middle school teachers. Following this…

  18. Factors Influencing Grant Writing of K-12 Teachers.

    ERIC Educational Resources Information Center

    Turpin, Tammye; Cage, Bob N.

    A study examined whether number of years of teaching, number of grant proposals written, and level of funding received were distinguished among K-12 teachers in relationship to factors perceived as motivating grant writing; obstacles encountered in grant writing; and needed support for continued grant writing. Questionnaires were mailed to 121…

  19. Enriching K-12 Science and Mathematics Education Using LEGOs

    ERIC Educational Resources Information Center

    Williams, Keeshan; Igel, Irina; Poveda, Ronald; Kapila, Vikram; Iskander, Magued

    2012-01-01

    This paper presents a series of illustrative LEGO Mindstorms-based science and math activities, developed under an NSF GK-12 Fellows project, for elementary, middle, and high school grades. The activities, developed by engineering and science graduate Fellows in partnership with K-12 teachers, are grade appropriate, address pertinent learning…

  20. K-12 Marketplace Sees Major Flow of Venture Capital

    ERIC Educational Resources Information Center

    Ash, Katie

    2012-01-01

    The flow of venture capital into the K-12 education market has exploded over the past year, reaching its highest transaction values in a decade in 2011, industry observers say. They attribute that rise to such factors as a heightened interest in educational technology; the decreasing cost of electronic devices such as tablet computers, laptops,…

  1. GOP Candidates Eye Scaling Back Federal K-12 Role

    ERIC Educational Resources Information Center

    Klein, Alyson

    2012-01-01

    Though education has played second fiddle so far to other domestic issues in the race for the Republican presidential nomination, the narrowing field includes GOP candidates with compatible views on scaling back the federal role in K-12, but big contrasts in policy specifics and experience. President Barack Obama, meanwhile, is expected to put a…

  2. Unified Science Approach K-12, Proficiency Levels 7-12.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented is the second part of the K-12 unified science materials used in the public schools of Anne Arundel County, Maryland. Detailed descriptions are made of the roles of students and teachers, purposes of the bibliography, major concepts in unified science, processes of inquiry, a scheme and model for scientific literacy, and program…

  3. New K-12 Science Education Standards May Face Implementation Challenges

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    2013-04-01

    Kindergarten is not just a place to learn letters and numbers, practice finger painting, and listen to story time. If a new set of national science standards is adopted, it will also be the start of a carefully planned effort to engage students in science-based activities throughout their K-12 academic careers.

  4. K-12 Foreign Language Education. The ERIC Review.

    ERIC Educational Resources Information Center

    ERIC Review, 1998

    1998-01-01

    The "ERIC Review" announces research results, publications, and new programs relevant to each issue's theme. This issue focuses on foreign language education in grades K-12. Articles include: "Second Language Learning: Everyone Can Benefit" (Kathleen M. Marcos); "Foreign Language Education in the United States: Trends and Challenges" (Renate A.…

  5. Unifying K-12 Learning Processes: Integrating Curricula through Learning

    ERIC Educational Resources Information Center

    Bosse, Michael J.; Fogarty, Elizabeth A.

    2011-01-01

    This study was designed to examine whether a set of cross-curricular learning processes could be found in the respective K-12 US national standards for math, language arts, foreign language, science, social studies, fine arts, and technology. Using a qualitative research methodology, the standards from the national associations for these content…

  6. Visual Literacy Through Picture Books K-12: A Curriculum Approach.

    ERIC Educational Resources Information Center

    Laughlin, Mildred

    An effective and easily overlooked resource for conducting visual literacy activities at the elementary secondary level is the picture book collection found in most elementary school libraries. In these times of inflated prices and budget reductions, K-12 librarians and teachers should not fail to make use of these materials. There are a variety…

  7. Student Recommendations for Improving Nutrition in America's K-12 Schools

    ERIC Educational Resources Information Center

    NCSSSMST Journal, 2006

    2006-01-01

    Co-hosted by the National Consortium for Specialized Secondary Schools of Mathematics, Science, and Technology (NCSSSMST) and The Keystone Center, the third annual Keystone Center Youth Policy Summit focused on Adolescent and Childhood Nutrition in America's K-12 Schools. In June 2006, 40 students from 10 math and science schools came together in…

  8. Outstanding Science Trade Books for Students K-12.

    ERIC Educational Resources Information Center

    Science Scope, 2002

    2002-01-01

    Presents a list of outstanding science trade books published in 2001 for use in the K-12 grade levels. Includes the areas of archaeology, anthropology, and paleontology; biography; life sciences; integrated science; physical sciences; science related careers; and technology and engineering. Provides information on the books and the selection…

  9. Outstanding Science Trade Books for Students K-12.

    ERIC Educational Resources Information Center

    Science and Children, 2002

    2002-01-01

    Introduces a list of outstanding science trade books for grade levels K-12 in the areas of Archaeology, Anthropology, Paleontology, Biography, Life Sciences, Integrated Science, Physical Science, Science Related Careers, and Technology and Engineering. Includes information on the selection process. (YDS)

  10. Florida's Opinion on K-12 Public Education Spending

    ERIC Educational Resources Information Center

    Forster, Greg

    2006-01-01

    This scientifically representative poll of 1,200 Floridians finds that public opinion about K-12 public education spending is seriously misinformed. Floridians think public schools need more money, but the main reason is that they are badly mistaken about how much money the public schools actually get. Key findings of the study include: (1) Half…

  11. Project WILD Aquatic K-12 Curriculum and Activity Guide

    ERIC Educational Resources Information Center

    Council for Environmental Education, 2011

    2011-01-01

    The "Project WILD Aquatic K-12 Curriculum and Activity Guide" emphasizes aquatic wildlife and aquatic ecosystems. It is organized in topic units and is based on the Project WILD conceptual framework. Because these activities are designed for integration into existing courses of study, instructors may use one or many Project WILD Aquatic activities…

  12. Project WILD K-12 Curriculum and Activity Guide

    ERIC Educational Resources Information Center

    Council for Environmental Education, 2011

    2011-01-01

    The "Project WILD K-12 Curriculum and Activity Guide" focuses on wildlife and habitat. It is organized in topic units and is based on the Project WILD conceptual framework. Because these activities are designed for integration into existing courses of study, instructors may use one or many Project WILD activities or the entire set of activities…

  13. A Guide to Networking for K-12 Schools.

    ERIC Educational Resources Information Center

    Northwest Regional Educational Lab., Portland, OR.

    The purpose of this guide is to provide basic networking information and planning assistance for technology coordinators and others involved in building networks for K-12 schools. The information in this guide focuses on the first few steps in the networking process. It reviews planning considerations and network design issues facing educators who…

  14. Education Nation: Obama, Romney Outline Different K-12, Postsecondary Priorities

    ERIC Educational Resources Information Center

    Dervarics, Charles

    2012-01-01

    With negative ads already rampant on radio and TV, it's clear that President Obama and Republican presidential nominee Mitt Romney differ on most issues. That statement carries over to education as well, as both offer starkly different views on K-12 and higher education policy for the fall campaign. Obama is touting a large increase in Pell Grants…

  15. Engineering a Dynamic Science Learning Environment for K-12 Teachers

    ERIC Educational Resources Information Center

    Hardre, Patricia L.; Nanny, Mark; Refai, Hazen; Ling, Chen; Slater, Janis

    2010-01-01

    The present study follows a cohort of 17 K-12 teachers through a six-week resident learning experience in science and engineering, and on into the planning and implementation of applications for their classrooms. This Research Experiences for Teachers (RET) program was examined using the strategic approach of design-based research, with its fluid,…

  16. The Web in K-12 Education: Is there a Future?

    ERIC Educational Resources Information Center

    Maddux, Cleborne D.

    2005-01-01

    Growth in size and popularity of the Web over the last 10 years has been remarkable. There are now many calls to make the Web the center of K-12 schooling. However, there are many problems that must be solved before the Web can be fully integrated into curricula in public schools. Such problems can be categorized as practical or pedagogical in…

  17. Teaching Engineering at the K-12 Level: Two Perspectives

    ERIC Educational Resources Information Center

    Smith, Kenneth L.; Burghardt, David

    2007-01-01

    In this article, the authors share their own perspectives regarding engineering education at the K-12 level. Smith believes that there must be a more direct infusion of appropriate mathematics and science with the unique technological content (tools, machines, materials, processes) for an effective engineering education program to exist. He thinks…

  18. Evaluating the Performance of Online K-12 Schools

    ERIC Educational Resources Information Center

    Carpenter, Dick; Kafer, Krista; Reeser, Kelly; Shafer, Sheryl

    2015-01-01

    This article examines K-12 online student and school performance across an entire state (Colorado) in the United States through two comparisons. First, state assessment scores of students in online schools are compared to those in traditional brick and mortar schools. Second, the accountability scores of online schools are compared to those of…

  19. Health and Safety Guide for K-12 Schools in Washington.

    ERIC Educational Resources Information Center

    Ellis, Richard E.; Kerns, James T.; Currie, Michael

    This guide, which can be used as a school self-inspection tool, is designed to help Washington's K-12 public schools prevent and reduce injuries and illnesses by focusing on good health and safety practices. The guide also focuses on practices that can be undertaken during the design, construction, renovation, operation, maintenance, or inspection…

  20. 2008 Public Opinion Survey on K-12 Education in Indiana

    ERIC Educational Resources Information Center

    Plucker, Jonathan A.; Spradlin, Terry E.; Burroughs, Nathan A.; Hiller, Stephen C.

    2008-01-01

    During the course of each calendar year since 2003, staff of the Center for Evaluation & Education Policy (CEEP) at Indiana University evaluates the benefits of continuing the Annual Public Opinion Survey on K-12 Education in Indiana. In 2008, the Indiana legislature determined that school corporations would no longer use property tax revenues to…

  1. Intergovernmental Approaches for Strengthening K-12 Accountability Systems

    ERIC Educational Resources Information Center

    Armour-Garb, Allison, Ed.

    2007-01-01

    This volume contains an edited transcript of the Rockefeller Institute's October 29, 2007 symposium (Chicago, IL) entitled "Intergovernmental Approaches to Strengthen K-12 Accountability Systems" as well as a framework paper circulated in preparation for the symposium. The transcript begins with a list of the forty state and federal education…

  2. Types, Subjects, and Purposes of K-12 Online Learning Interactions

    ERIC Educational Resources Information Center

    Borup, Jered

    2013-01-01

    Although K-12 online learning has experienced exceptional growth, research in the area has lagged behind. This dissertation addressed this gap in the literature using a multiple article dissertation format. The first article used survey data from two online English courses at the Open High School of Utah (OHSU) to examine students' reported…

  3. Environmental Education: Food - The Coming Crisis (Grades K-12).

    ERIC Educational Resources Information Center

    New Jersey State Council for Environmental Education, Upper Montclair.

    This publication presents classroom activities for teaching about the world food shortage. These activities are organized by objectives, are multidisciplinary and cover the K-12 grade levels. The objectives listed include: (1) Describe some food chains; (2) Appraise the effect of soil conditions, geographic and climatic factors on the food…

  4. Tablets in K-12 Education: Integrated Experiences and Implications

    ERIC Educational Resources Information Center

    An, Heejung, Ed.; Alon, Sandra, Ed.; Fuentes, David, Ed.

    2015-01-01

    The inclusion of new and emerging technologies in the education sector has been a topic of interest to researchers, educators, and software developers alike in recent years. Utilizing the proper tools in a classroom setting is a critical factor in student success. "Tablets in K-12 Education: Integrated Experiences and Implications"…

  5. Technological Collaborations: K-12 and Higher Education. Fastback 438.

    ERIC Educational Resources Information Center

    Ferguson, Kay McPherson; Kopp, O. W.

    This brief report examines various ways in which K-12 schools and institutions of higher education can collaborate to effect critical changes in teaching and learning through the use of computers. The first section briefly reviews the history of computer use in education, noting such critical needs as teacher training, and reviews the…

  6. Meaningful Involvement of Science Undergraduates in K-12 Outreach

    ERIC Educational Resources Information Center

    Rao, Sujaya; Shamah, Devora; Collay, Ryan

    2007-01-01

    The authors argue for the involvement of science undergraduates in K-12 outreach to enhance their communication skills, generate enthusiasm for science in today's youth, and extend relationships between institutions of higher learning and surrounding communities. Here we present three opportunities created at Oregon State University for engaging…

  7. Purposeful Partnerships: Linking Preservice Teachers with Diverse K-12 Students

    ERIC Educational Resources Information Center

    McClanahan, Lauren; Buly, Marsha Riddle

    2009-01-01

    One of the greatest challenges of any K-12 teacher education program is providing pre-service teachers opportunities to work with students who are culturally and linguistically different from themselves. Despite best efforts of selecting texts and facilitating discussions, new teachers recently interviewed report that coursework just did not help…

  8. Comprehension Across the Curriculum: Perspectives and Practices K-12

    ERIC Educational Resources Information Center

    Ganske, Kathy, Ed.; Fisher, Douglas, Ed.

    2009-01-01

    Successful students use comprehension skills and strategies throughout the school day. In this timely book, leading scholars present innovative ways to support reading comprehension across content areas and the full K-12 grade range. Chapters provide specific, practical guidance for selecting rewarding texts and promoting engagement and…

  9. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 20 science activities for students K-12. Topics include role playing, similarities between urban and forest communities, ecosystems, garbage, recycling, food production, habitats, insects, tidal zone, animals, diversity, interest groups, rivers, spaceship earth, ecological interactions, and the cost of recreation. (KR)

  10. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1991

    1991-01-01

    Presented are 38 environmental education activities for grades K-12. Topics include seed dispersal, food chains, plant identification, sizes and shapes, trees, common names, air pollution, recycling, temperature, litter, water conservation, photography, insects, urban areas, diversity, natural cycles, rain, erosion, phosphates, human population,…

  11. Foreign Language K-12. Program Evaluation 1991-92.

    ERIC Educational Resources Information Center

    Wadden, Jerry M.

    The Des Moines (Iowa) Public Schools foreign language program for K-12 is described and evaluated. The evaluation report focuses on six areas, including: (1) school district mission and philosophy of foreign language instruction; (2) context (state policies and standards, foreign language program overview and enrollment, fiber-optic communication…

  12. Service-Learning: Motivations for K-12 Teachers

    ERIC Educational Resources Information Center

    Krebs, Marjori M.

    2006-01-01

    The purpose of this dissertation is to describe the essence of the service-learning experience for K-12 teachers in central and northwest Ohio, specifically exploring teacher motivations for initiating service-learning in the classroom. Service-learning is defined as an educational methodology that incorporates student preparation, service to the…

  13. Definitions, Benefits, and Barriers of K-12 Educational Strategic Planning

    ERIC Educational Resources Information Center

    Hambright, Grant; Diamantes, Thomas

    2004-01-01

    This comprehensive literature review seeks to define strategic planning in a K-12 setting. Principally, it asks, what characteristics distinguish educational strategic planning from other planning approaches? What follows is a content analysis of the educational strategic planning literature detailing the critical attributes of various planning…

  14. Course Goals in Health Education, Grades K-12. Critique Draft.

    ERIC Educational Resources Information Center

    Multnomah County Intermediate Education District, Portland, OR.

    This document on course goals in health education is one part of a critique series of eight documents dealing with the development and evaluation of course goals in six subject matter areas for grades K-12. The series provides an initial pool of course-level goals that are expected to be of considerable value in assisting educators with goal…

  15. K-12 and University Partnerships: Bridging the Advocacy Gap

    ERIC Educational Resources Information Center

    Bryan, Charity; Sims, Sandra

    2011-01-01

    Research has cited numerous advantages and benefits of K-12 collaborations with the larger university community (Castle, Fox, & Souder, 2006; Crocco, Faithfull, & Schwartz, 2003). Departments of kinesiology across the country are well positioned to establish partnerships with local school systems in order to advocate for quality, daily physical…

  16. Course Goals in Social Science, Grades K-12. Critique Draft.

    ERIC Educational Resources Information Center

    Multnomah County Intermediate Education District, Portland, OR.

    This document on course goals in the social sciences is one part of a critique series dealing with the development and evaluation of course goals in six subject matter areas for grades K-12. The series provides an initial pool of course-level goals that are expected to be of considerable value in assisting educators with goal definition related to…

  17. Information Security Management Practices of K-12 School Districts

    ERIC Educational Resources Information Center

    Nyachwaya, Samson

    2013-01-01

    The research problem addressed in this quantitative correlational study was the inadequacy of sound information security management (ISM) practices in K-12 school districts, despite their increasing ownership of information assets. Researchers have linked organizational and sociotechnical factors to the implementation of information security…

  18. Course Goals in Art, Grades K-12. Critique Draft.

    ERIC Educational Resources Information Center

    Multnomah County Intermediate Education District, Portland, OR.

    This document on course goals in art is one part of a critique series dealing with the development and evaluation of course goals in six subject matter areas for grades K-12. The series provides an initial pool of course-level goals that are expected to be of considerable value in assisting educators with goal definition related to curriculum…

  19. The Green Pages: Environmental Education Activities K-12.

    ERIC Educational Resources Information Center

    Clearing, 1990

    1990-01-01

    Presented are 37 environmental science activities for students in grades K-12. Topics include water pollution, glaciers, protective coloration, shapes in nature, environmental impacts, recycling, creative writing, litter, shapes found in nature, color, rain cycle, waste management, plastics, energy, pH, landfills, runoff, watersheds,…

  20. Building a Bridge to College Success in K-12.

    ERIC Educational Resources Information Center

    Senge, Jeffrey C.

    This paper presents some possible reasons why persons with visual impairments are under-represented in the fields of mathematics and science, including insufficient general preparation for higher education during the K-12 years and the lack of effective alternative instructional materials and methods available to a person with a visual impairment…

  1. Scientists, Research Centers and K-12 Science and Mathematics Education

    NASA Astrophysics Data System (ADS)

    Haase, David G.

    2001-11-01

    In recent years the federal funding agencies have put increased emphasis on the involvement of scientists in K-12 education. This emphasis is seen in the program descriptions for NSF Career awards, for NSF collaborative research centers and for NASA Education and Public Outreach supplemental contracts. There is ample motivation Ð e.g. funding, the health of public education, and the future of the scientific enterprise - for scientists and science research centers to connect to K-12. I will review what the education literature and national reports say about how scientists and research centers should be and should not be, involved in K-12 education. These roles and opportunities will be illustrated by examples of K-12 education outreach from The Science House at NC State and the NSF Center for Environmentally Responsible Solvents and Processes. This material is based upon work supported by the STC Program of the National Science Foundation under Agreement No. CHE-9876674 and by the Burroughs Wellcome Fund.

  2. Media Literacy and the K-12 Content Areas

    ERIC Educational Resources Information Center

    Hobbs, Renee

    2005-01-01

    Media literacy education is being explored by scholars in many different fields (including education, literature, media studies, psychology, and public health), but there is less evidence of implementations occurring in K-12 settings. With more than 1.3 million teachers in U.S. public schools, it is impossible to estimate the extent to which the…

  3. Winona State University Anthology of K-12 Action Research Papers

    ERIC Educational Resources Information Center

    Sherman, Thomas F., Ed.; Lundquist, Margaret, Ed.

    2004-01-01

    These papers are partial fulfillment of the requirements for the Master of Science Degree in Education at Winona State University in Winona, Minnesota. The cohort included a variety of licenser areas that represent most levels and content areas of K-12 education. The students were encouraged to keep their questions and hypothesis directed at…

  4. Addressing Excellence Gaps in K-12 Education. Position Statement

    ERIC Educational Resources Information Center

    National Association for Gifted Children, 2015

    2015-01-01

    Since the passage of the No Child Left Behind Act in 2001, a major objective of federal and state education policy has been to narrow K-12 achievement gaps. This position statement notes that the available data suggest that the singular focus on the most struggling learners has resulted in meaningful progress in closing minimum-competency…

  5. Classrooms and Courtrooms: Facing Sexual Harassment in K-12 Schools.

    ERIC Educational Resources Information Center

    Stein, Nan

    This book uses evidence gathered from legal, anecdotal, and survey-based sources to explore sexual harassment in K-12 schools. The text is divided into seven chapters. Chapters 1 and 2 use material from surveys, salient lawsuits, and students' stories to describe harassment and to elaborate on the contradictions and confusions that surround this…

  6. Active Commuting among K-12 Educators: A Study Examining Walking and Biking to Work

    PubMed Central

    Bopp, Melissa; Hastmann, Tanis J.; Norton, Alyssa N.

    2013-01-01

    Background. Walking and biking to work, active commuting (AC) is associated with many health benefits, though rates of AC remain low in the US. K-12 educators represent a significant portion of the workforce, and employee health and associated costs may have significant economic impact. Therefore, the purpose of this study was to examine the current rates of AC and factors associated with AC among K-12 educators. Methods. A volunteer sample of K-12 educators (n = 437) was recruited to participate in an online survey. Participants responded about AC patterns and social ecological influences on AC (individual, interpersonal, institutional, community, and environmental factors). t-tests and ANOVAs examined trends in AC, and Pearson correlations examined the relationship between AC and dependent variables. Multiple regression analysis determined the relative influence of individual, interpersonal, institutional, community, and environmental levels on AC. Results. Participants actively commuted 0.51 ± 1.93 times/week. There were several individual, interpersonal, institutional, community, and environmental factors significantly related to AC. The full model explained 60.8% of the variance in AC behavior. Conclusions. This study provides insight on the factors that determine K-12 educators mode of commute and provide some insight for employee wellness among this population. PMID:24089620

  7. K-12 Students Flock To ToxTown In San Diego: Results of an SOT K-12 Education Outreach Workshop

    EPA Science Inventory

    Just prior to the start of the 2015 Annual Meeting in San Diego, hundreds of K-12 students, teachers, and science enthusiasts visited the ToxTown booth at the annual San Diego Festival of Science and Engineering grand finale event, EXPO Day. Over 20,000 attendees participated in ...

  8. HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers

    PubMed Central

    2011-01-01

    Background RNA silencing is used in plants as a major defence mechanism against invasive nucleic acids, such as viruses. Accordingly, plant viruses have evolved to produce counter defensive RNA-silencing suppressors (RSSs). These factors interfere in various ways with the RNA silencing machinery in cells, and thereby disturb the microRNA (miRNA) mediated endogene regulation and induce developmental and morphological changes in plants. In this study we have explored these effects using previously characterized transgenic tobacco plants which constitutively express (under CaMV 35S promoter) the helper component-proteinase (HC-Pro) derived from a potyviral genome. The transcript levels of leaves and flowers of these plants were analysed using microarray techniques (Tobacco 4 × 44 k, Agilent). Results Over expression of HC-Pro RSS induced clear phenotypic changes both in growth rate and in leaf and flower morphology of the tobacco plants. The expression of 748 and 332 genes was significantly changed in the leaves and flowers, respectively, in the HC-Pro expressing transgenic plants. Interestingly, these transcriptome alterations in the HC-Pro expressing tobacco plants were similar as those previously detected in plants infected with ssRNA-viruses. Particularly, many defense-related and hormone-responsive genes (e.g. ethylene responsive transcription factor 1, ERF1) were differentially regulated in these plants. Also the expression of several stress-related genes, and genes related to cell wall modifications, protein processing, transcriptional regulation and photosynthesis were strongly altered. Moreover, genes regulating circadian cycle and flowering time were significantly altered, which may have induced a late flowering phenotype in HC-Pro expressing plants. The results also suggest that photosynthetic oxygen evolution, sugar metabolism and energy levels were significantly changed in these transgenic plants. Transcript levels of S-adenosyl-L-methionine (SAM) were

  9. Soil Science Society of America - K-12 Outreach

    NASA Astrophysics Data System (ADS)

    Lindbo, David L.; Loynachan, Tom; Mblia, Monday; Robinson, Clay; Chapman, Susan

    2013-04-01

    The Soil Science Society of America created its K12 Committee in 2006 in part to compliment the Dig It! The Secrets of Soil exhibit that opened in July 2008 at the Smithsonian's Institution's Nation Museum of Natural History (of which SSS was a founding sponsor). The committee's work began quickly with a website designed to provide resources for K12 teachers. The first accomplishments included reviewing and posting links to web based information already available to teachers. These links were sorted by subject and grade level to make it easier for teachers to navigate the web and find what they needed quickly. Several presentations and lessons designed for K12 teachers were also posted at this time. Concurrent with this effort a subcommittee review and organized the national teaching standards to show where soils could fit into the overall K12 curriculum. As the website was being developed another subcommittee developed a soils book (Soil! Get the Inside Scoop, 2008) to further compliment the Dig It! exhibit. This was a new endeavor for SSSA having never worked with the non-academic audience in developing a book. Peer-reviews of this book included not only scientist but also students in order to make sure the book was attractive to them. Once the book was published and the website developed it became clear more outreach was needed. SSSA K12 Committee has attended both the National Science Teachers Association (since 2008) the USA Science and Engineering Festival (since 2010) with exhibits and workshops. It has cooperated and contributed to the American Geologic Institutes' Earth Science Week materials with brochures and lesson plans and with National Association of Conservation Districts by providing peer-review and distribution of materials. The most recent developments from the committee include a web redesign that is more student and teacher friendly, the development of a peer-review system to publish K12 Lesson Plans, and finally the publication of a new soils

  10. Genetic alterations of histone lysine methyltransferases and their significance in breast cancer

    PubMed Central

    Liu, Hui; Holowatyj, Andreana; Yang, Zeng-Quan

    2015-01-01

    Histone lysine methyltransferases (HMTs), a large class of enzymes that catalyze site-specific methylation of lysine residues on histones and other proteins, play critical roles in controlling transcription, chromatin architecture, and cellular differentiation. However, the genomic landscape and clinical significance of HMTs in breast cancer remain poorly characterized. Here, we conducted a meta-analysis of approximately 50 HMTs in breast cancer and identified associations among recurrent copy number alterations, mutations, gene expression, and clinical outcome. We identified 12 HMTs with the highest frequency of genetic alterations, including 8 with high-level amplification, 2 with putative homozygous deletion, and 2 with somatic mutation. Different subtypes of breast cancer have different patterns of copy number and expression for each HMT gene. In addition, chromosome 1q contains four HMTs that are concurrently or independently amplified or overexpressed in breast cancer. Copy number or mRNA expression of several HMTs was significantly associated with basal-like breast cancer and shorter patient survival. Integrative analysis identified 8 HMTs (SETDB1, SMYD3, ASH1L, SMYD2, WHSC1L1, SUV420H1, SETDB2, and KMT2C) that are dysregulated by genetic alterations, classifying them as candidate therapeutic targets. Together, our findings provide a strong foundation for further mechanistic research and therapeutic options using HMTs to treat breast cancer. PMID:25537518

  11. K-12 Math and Science Education: A Physicist Meets Reality

    NASA Astrophysics Data System (ADS)

    Eisenstein, Robert

    2009-05-01

    Can professional engineers, mathematicians, and scientists have a positive impact on K-12 math and science education? The experience of the Santa Fe Alliance for Science, and several other like-minded organizations, indicates that they can indeed. But success is by no means assured. Good scientists are not automatically good educators, but they can learn enough about pedagogy, classroom, and community to do well. For example, their experiences working on research topics of great societal interest (e.g. the energy supply or global warming) can be a great attraction to young people. This discussion will be oriented around three major points: lessons learned, prospects for the future, and how our effort fits into state-wide plans for re-inventing K-12 math and science education in New Mexico.

  12. Core Curriculum for Social Studies Education K-12.

    ERIC Educational Resources Information Center

    Utah State Office of Education, Salt Lake City. Office of Curriculum and Instruction.

    The Utah social studies curriculum for grades K-12 is divided into three levels: K-6, 7-8, and 9-12. For K-6, mastery of core concepts is required; for grades 7-8, 1.5 units of United States History and Utah studies are required; and for grades 9-12, three units of world cultural geography, ancient world civilizations, European history, United…

  13. Use of Cooperative K-12 Water Quality Data by Scientists

    NASA Astrophysics Data System (ADS)

    Conklin, M. H.; Clemons, J.; Bales, R. C.

    2001-05-01

    Cooperative data collected by volunteers who are not paid professionals has been successfully used in weather observations, groundwater levels, and water quality. However, the notion of involving K-12 students directly in research, specifically concerning water quality data, has left many research scientists wondering "what about quality assurance and control (QA/QC)?" Global Learning and Observations to Benefit the Environment (GLOBE) is a worldwide network of K-12 students, teachers, and scientists working together to study and understand the global environment. Students and teachers from over 8,000 schools in more than 80 countries are working with research scientists to learn more about our planet. GLOBE students make environmental observations (hydrology, meteorology, soils, and other measurements) at or near their schools and report their data through the Internet (www.globe.gov). GLOBE and other parallel K-12 volunteer measurement programs have developed multi-year records of stream water quality at locations where career scientists do not or only infrequently sample. Since 1995, over 600 GLOBE schools throughout the U.S. have gathered and reported surface water quality data for alkalinity, electrical conductivity, dissolved oxygen, pH, and temperature. A comparative analysis of GLOBE and USGS water quality data, and the protocols used to make these measurements, was done to assess: i) how measurement protocols compare qualitatively, ii) how the variability in data compare, and iii) what spatial and/or temporal patterns are apparent in the data. When compared to equivalent USGS protocols, it becomes apparent that some of the GLOBE hydrology protocols can be improved. However there are limits to the quality of K-12 data imposed by the levels of scientific training of participants and sophistication of instrumentation. The higher spatial and statistical variability of GLOBE data compared to USGS data makes it unsuited for use as a stand-alone method for

  14. Involving Practicing Scientists in K-12 Science Teacher Professional Development

    NASA Astrophysics Data System (ADS)

    Bertram, K. B.

    2011-12-01

    The Science Teacher Education Program (STEP) offered a unique framework for creating professional development courses focused on Arctic research from 2006-2009. Under the STEP framework, science, technology, engineering, and math (STEM) training was delivered by teams of practicing Arctic researchers in partnership with master teachers with 20+ years experience teaching STEM content in K-12 classrooms. Courses based on the framework were offered to educators across Alaska. STEP offered in-person summer-intensive institutes and follow-on audio-conferenced field-test courses during the academic year, supplemented by online scientist mentorship for teachers. During STEP courses, teams of scientists offered in-depth STEM content instruction at the graduate level for teachers of all grade levels. STEP graduate-level training culminated in the translation of information and data learned from Arctic scientists into standard-aligned lessons designed for immediate use in K-12 classrooms. This presentation will focus on research that explored the question: To what degree was scientist involvement beneficial to teacher training and to what degree was STEP scientist involvement beneficial to scientist instructors? Data sources reveal consistently high levels of ongoing (4 year) scientist and teacher participation; high STEM content learning outcomes for teachers; high STEM content learning outcomes for students; high ratings of STEP courses by scientists and teachers; and a discussion of the reasons scientists indicate they benefited from STEP involvement. Analyses of open-ended comments by teachers and scientists support and clarify these findings. A grounded theory approach was used to analyze teacher and scientist qualitative feedback. Comments were coded and patterns analyzed in three databases. The vast majority of teacher open-ended comments indicate that STEP involvement improved K-12 STEM classroom instruction, and the vast majority of scientist open-ended comments

  15. Released products of pathogenic bacteria stimulate biofilm formation by Escherichia coli K-12 strains.

    PubMed

    Vacheva, Anna; Ivanova, Radka; Paunova-Krasteva, Tsvetelina; Stoitsova, Stoyanka

    2012-06-01

    It has recently been shown that pathogens with a limited capacity for sessile growth (like some Escherichia coli O157 strains) can benefit from the presence of other bacteria and form mixed biofilms with companion strains. This study addresses the question whether pathogens may influence attached growth of E. coli non-pathogenic strains via secreted factors. We compared the biofilm-modulating effects of sterile stationary-phase culture media of a biofilm non-producing strain of E. coli O157:H, a laboratory biofilm-producing E. coli K-12 strain and a biofilm-forming strain of the pathogen Yersina enterocolitica O:3. Sessile growth was monitored as biomass (crystal violet assay), exopolysaccharide (ELLA) and morphology (scanning electron and confocal laser microscopy). With two of the E. coli K-12 strains stimulation of biofilm formation by all supernatants was achieved, but only the pathogens' secreted products induced biomass increase in some 'biofilm-deficient' K-12 strains. Lectin-peroxidase labeling indicated changes in colanic acid and poly-N-acetylglucosamine amounts in extracellular matrices. The contribution of indole, protein and polysaccharide to the biofilm-modulating activities of the supernatants was compared. Indole, in concentrations equal to those established in the supernatants, suppressed sessile growth in one K-12 strain. Proteinase K significantly reduced the stimulatory effects of all supernatants, indicating a prominent role of protein/peptide factor(s) in biofilm promotion. The amount of released polysaccharides (rPS) in the supernatants was quantitated then comparable quantities of isolated rPS were applied during biofilm growth. The three rPS had notable strain-specific effects with regard to both the strain-source of the rPS and the E. coli K-12 target strain.

  16. Females and STEM: Determining the K-12 Experiences that Influenced Women to Pursue STEM Fields

    NASA Astrophysics Data System (ADS)

    Petersen, Anne Marie

    In the United States, careers in the fields of Science, Technology, Engineering, and Mathematics (STEM) are increasing yet there are not enough trained personnel to meet this demand. In addition, of those that seek to pursue STEM fields in the United States, only 26% are female. In order to increase the number of women seeking STEM based bachelor's degrees, K-12 education must provide a foundation that prepares students for entry into these fields. The purpose of this phenomenological study was to determine the perceived K-12 experiences that influenced females to pursue a STEM field. Twelve college juniors or seniors seeking a degree in Biology, Mathematics, or Physics were interviewed concerning their K-12 experiences. These interviews were analyzed and six themes emerged. Teacher passion and classroom characteristics such as incorporating challenging activities played a significant role in the females' decisions to enter STEM fields. Extra-curricular activities such as volunteer and mentor opportunities and the females' need to benefit others also influenced females in their career choice. Both the formal (within the school) and informal (outside of the traditional classroom) pipeline opportunities that these students encountered helped develop a sense of self-efficacy in science and mathematics; this self-efficacy enabled them to persist in pursuing these career fields. Several participants cited barriers that they encountered in K-12 education, but these barriers were primarily internal as they struggled with overcoming self-imposed obstacles in learning and being competitive in the mathematics and science classrooms. The experiences from these female students can be used by K-12 educators to prepare and encourage current female students to enter STEM occupations.

  17. Altered cortical microarchitecture in patients with monoclonal gammopathy of undetermined significance

    PubMed Central

    Farr, Joshua N.; Zhang, Wei; Kumar, Shaji K.; Jacques, Richard M.; Ng, Alvin C.; McCready, Louise K.; Rajkumar, S. Vincent

    2014-01-01

    Patients with monoclonal gammopathy of undetermined significance (MGUS) are at increased fracture risk, and we have previously shown that MGUS patients have altered trabecular bone microarchitecture compared with controls. However, there are no data on whether the porosity of cortical bone, which may play a greater role in bone strength and the occurrence of fractures, is increased in MGUS. Thus, we studied cortical porosity and bone strength (apparent modulus) using high-resolution peripheral quantitative computed tomography imaging of the distal radius in 50 MGUS patients and 100 age-, gender-, and body mass index–matched controls. Compared with controls, MGUS patients had both significantly higher cortical porosity (+16.8%; P < .05) and lower apparent modulus (–8.9%; P < .05). Despite their larger radial bone size, MGUS patients have significantly increased cortical bone porosity and reduced bone strength relative to controls. This increased cortical porosity may explain the increased fracture risk seen in MGUS patients. PMID:24227822

  18. Infrared Astronomy Professional Development for K-12 Educators: WISE Telescope

    NASA Astrophysics Data System (ADS)

    Borders, Kareen; Mendez, B. M.

    2010-01-01

    K-12 educators need effective and relevant astronomy professional development. WISE Telescope (Wide-Field Infrared Survey Explorer) and Spitzer Space Telescope Education programs provided an immersive teacher professional development workshop at Arecibo Observatory in Puerto Rico during the summer of 2009. As many common misconceptions involve scale and distance, teachers worked with Moon/Earth scale, solar system scale, and distance of objects in the universe. Teachers built and used basic telescopes, learned about the history of telescopes, explored ground and satellite based telescopes, and explored and worked on models of WISE Telescope. An in-depth explanation of WISE and Spitzer telescopes gave participants background knowledge for infrared astronomy observations. We taught the electromagnetic spectrum through interactive stations. The stations included an overview via lecture and power point, the use of ultraviolet beads to determine ultraviolet exposure, the study of WISE lenticulars and diagramming of infrared data, listening to light by using speakers hooked up to photoreceptor cells, looking at visible light through diffraction glasses and diagramming the data, protocols for using astronomy based research in the classroom, and infrared thermometers to compare environmental conditions around the observatory. An overview of LIDAR physics was followed up by a simulated LIDAR mapping of the topography of Mars. We will outline specific steps for K-12 infrared astronomy professional development, provide data demonstrating the impact of the above professional development on educator understanding and classroom use, and detail future plans for additional K-12 professional development. Funding was provided by WISE Telescope, Spitzer Space Telescope, Starbucks, Arecibo Observatory, the American Institute of Aeronautics and Astronautics, and the Washington Space Grant Consortium.

  19. AIAA Educator Academy: Enriching STEM Education for K-12 Students

    NASA Astrophysics Data System (ADS)

    Slagle, E.; Bering, E. A.; Longmier, B. W.; Henriquez, E.; Milnes, T.; Wiedorn, P.; Bacon, L.

    2012-12-01

    Educator Academy is a K-12 STEM curriculum developed by the STEM K-12 Outreach Committee of the American Institute of Aeronautics and Astronautics (AIAA). Consisting of three independent curriculum modules, K-12 students participate in inquiry-based engineering challenges to improve critical thinking skills and enhance problem solving skills. The Mars Rover Celebration Curriculum Module is designed for students in grades 3-8. Throughout this module, students learn about Mars and the solar system. Working with given design criteria, students work in teams to do basic research about Mars that will determine the operational objectives and structural features of their rover. Then, students participate in the design and construction of a model of a mock-up Mars Rover to carry out a specific science mission on the surface of Mars. At the end of this project, students have the opportunity to participate in a regional capstone event where students share their rover designs and what they have learned. The Electric Cargo Plan Curriculum Module is designed for students in grades 6-12. Throughout this module, students learn about aerodynamics and the four forces of flight. Working individually or in teams, students design and construct an electrically-powered model aircraft to fly a tethered flight of at least one lap without cargo, followed by a second tethered flight of one lap carrying as much cargo as possible. At the end of this project, students have the opportunity to participate in a regional capstone event where students share what they have learned and compete with their different cargo plane designs. The Space Weather Balloon Curriculum Module is designed for students in grades 9-12. Throughout this module, students learn and refine physics concepts as well as experimental research skills. Students participate in project-based learning that is experimental in nature. Students are engaged with the world around them as they collaborate to launch a high altitude

  20. Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment

    PubMed Central

    Budczies, Jan; Pfarr, Nicole; Stenzinger, Albrecht; Treue, Denise; Endris, Volker; Ismaeel, Fakher; Bangemann, Nikola; Blohmer, Jens-Uwe; Dietel, Manfred; Loibl, Sibylle; Klauschen, Frederick; Weichert, Wilko; Denkert, Carsten

    2016-01-01

    Recently, it has been demonstrated that calling of copy number alterations (CNAs) from amplicon sequencing (AS) data is feasible. Most approaches, however, require non-tumor (germline) DNA for data normalization. Here, we present the method Ioncopy for CNA detection which requires no normal controls and includes a significance assessment for each detected alteration. Ioncopy was evaluated in a cohort of 184 clinically annotated breast carcinomas. A total number of 252 amplifications were detected, of which 183 (72.6%) could be validated by a call of an additional amplicon interrogating the same gene. Moreover, a total number of 33 deletions were found, whereof 27 (81.8%) could be validated. Analyzing the 16 most frequently amplified genes, validation rates of over 89% could be achieved for 11 of these genes. 11 of the top 16 genes showed significant overexpression in the amplified tumors. 89.5% of the HER2-amplified tumors were GRB7 and STARD3 co-amplified, whereas 68.4% of the HER2-amplified tumors had additional MED1 amplifications. Correlations between CNAs measured by amplicons in HER2 exons 19, 20 and 21 were strong (all R > 0.93). AS based detection of HER2 amplifications had a sensitivity of 90.0% and a specificity of 98.8% compared to the gold standard of HER2 immunohistochemistry combined with in situ hybridization. In summary, we developed and validated a novel method for detection and significance assessment of CNAs in amplicon sequencing data. Using Ioncopy, AS offers a straightforward and efficient approach to simultaneously analyze gene amplifications and gene deletions together with simple somatic mutations in a single assay. PMID:26910888

  1. Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase.

    PubMed

    Tani, Motohiro; Toume, Moeko

    2015-12-01

    In the yeast Saccharomyces cerevisiae, complex sphingolipids have three types of polar head group and five types of ceramide; however, the physiological significance of the structural diversity is not fully understood. Here, we report that deletion of vacuolar H+-ATPase (V-ATPase) in yeast causes dramatic alteration of the complex sphingolipid composition, which includes decreases in hydroxylation at the C-4 position of long-chain bases and the C-2 position of fatty acids in the ceramide moiety, decreases in inositol phosphorylceramide (IPC) levels, and increases in mannosylinositol phosphorylceramide (MIPC) and mannosyldiinositol phosphorylceramide [M(IP)2C] levels. V-ATPase-deleted cells exhibited slow growth at pH 7.2, whereas the increase in MIPC levels was significantly enhanced when V-ATPase-deleted cells were incubated at pH 7.2. The protein expression levels of MIPC and M(IP)2C synthases were significantly increased in V-ATPase-deleted cells incubated at pH 7.2. Loss of MIPC synthesis or an increase in the hydroxylation level of the ceramide moiety of sphingolipids on overexpression of Scs7 and Sur2 sphingolipid hydroxylases enhanced the growth defect of V-ATPase-deleted cells at pH 7.2. On the contrary, the growth rate of V-ATPase-deleted cells was moderately increased on the deletion of SCS7 and SUR2. In addition, supersensitivities to Ca2+, Zn2+ and H2O2, which are typical phenotypes of V-ATPase-deleted cells, were enhanced by the loss of MIPC synthesis. These results indicate the possibility that alteration of the complex sphingolipid composition is an adaptation mechanism for a defect of V-ATPase.

  2. Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

    PubMed Central

    Araya, Carlos L.; Cenik, Can; Reuter, Jason A.; Kiss, Gert; Pande, Vijay S.; Snyder, Michael P.; Greenleaf, William J.

    2015-01-01

    Cancer sequencing studies have primarily identified cancer-driver genes by the accumulation of protein-altering mutations. An improved method would be annotation-independent, sensitive to unknown distributions of functions within proteins, and inclusive of non-coding drivers. We employed density-based clustering methods in 21 tumor types to detect variably-sized significantly mutated regions (SMRs). SMRs reveal recurrent alterations across a spectrum of coding and non-coding elements, including transcription factor binding sites and untranslated regions mutated in up to ∼15% of specific tumor types. SMRs reveal spatial clustering of mutations at molecular domains and interfaces, often with associated changes in signaling. Mutation frequencies in SMRs demonstrate that distinct protein regions are differentially mutated among tumor types, as exemplified by a linker region of PIK3CA in which biophysical simulations suggest mutations affect regulatory interactions. The functional diversity of SMRs underscores both the varied mechanisms of oncogenic misregulation and the advantage of functionally-agnostic driver identification. PMID:26691984

  3. Communicating Regional Geology and Geohazards to K-12 Teachers

    NASA Astrophysics Data System (ADS)

    Pratt-Sitaula, B.; Butler, R. F.; Whitman, J. M.; Granshaw, F. D.; Magura, B.; Hedeen, C.; Groom, R.; Thompson, D.; Johnson, J. A.

    2011-12-01

    The Teachers on the Leading Edge (TOTLE) program has designed an innovative model for middle school teacher professional development related to Pacific NW plate margin hazards and EarthScope science. The program has been effective at improving teacher knowledge and confidence and has led to high rates of curricular implementation. The elements particularly key to success are: a) facilitation team with broad expertise in both geoscience and education; b) regional team format that encouraged learning community development; c) teachers' desire to focus on regional geologic hazards; d) significant use of animations and field trips to aid in "visualization" of processes; and e) extensive "kit" of teaching materials for easy classroom transfer. The 1-week workshops were held in summer 2008-2010 and 35 Pacific NW middle school teachers attended each year. Geoscientists from universities and research institutions conducted the field trips and content sessions. Master K-12 Earth science teachers designed or modified curricular materials and led the teaching implementation sessions. Each year, the teachers were divided into 5 regional teams led by geoscience educator team leaders (community college instructors or similar). Teachers were surveyed on teaching confidence and content knowledge before and after the workshops. Follow-up surveys addressed teaching confidence and curricular implementation and were conducted 0.7 years after (all cohorts), 1.7 years after (2009 cohort), and 2.7 years after (2008 cohort). Teacher confidence (4-point scale: 1="not at all confident"; 4="very confident") on workshop content topics continued to rise in each subsequent survey from 2.7 (pre) to 3.3 (post) to 3.5 (0.7 yr follow up) to 3.7 (2-3 yr follow up) suggesting the program impact is long-lived. In the post-workshop surveys, 100% of participants agreed or strongly agreed that the program would positively impact their teaching. Average teacher performance on content questions improved

  4. Characterization of lipopolysaccharides from Escherichia coli K-12 mutants.

    PubMed Central

    Boman, H G; Monner, D A

    1975-01-01

    Chemical analyses of the carbohydrate composition of lipopolysaccharides (LPS) from a number of LPS mutants were used to propose a schematic composition for the LPS from Escherichia coli K-12. The formula contains four regions: the first consists of lipid A, ketodeoxyoctonoic acid, and a phosphorous component; the second contains only heptose; the third only glucose; and the fourth additional glucose, galactose, and rhamnose. LPS from E. coli B may have a similar composition but lacks the galactose and rhamnose units. A set of LPS-specific bacteriophages were used for comparing three mutants of Salmonella with a number of LPS mutants of E. coli K-12. The results confirm that there are basic similarities in the first and second regions of the LPS structure; they also support the four region divisions of the LPS formula. Paper chromatography was used for characterization of 32-P-labeled LPS from different strains of E. coli and Salmonella. The Rf values for LPS varied from 0.27 to 0.75 depending on the amounts of carbohydrates in the molecule. LPS from all strains studied was homogenous except for strain D31 which produced two types of LPS. Mild acid hydrolysis of labeled LPS liberated lipid A and two other components with phosphate, one of which was assigned to the first region. It is suggested that paper chromatography can be used in biosynthetic studies concerning regions 2 to 4. Images PMID:1089628

  5. Polyphenols from olive mill waste affect biofilm formation and motility in Escherichia coli K-12

    PubMed Central

    Carraro, Lisa; Fasolato, Luca; Montemurro, Filomena; Martino, Maria Elena; Balzan, Stefania; Servili, Maurizio; Novelli, Enrico; Cardazzo, Barbara

    2014-01-01

    Olive mill wastes are sources of phenolic compounds with a wide array of biological activities, including antimicrobial effects. A potential option for bioremediation to overcome ecological problems is the reutilization of these natural compounds in food production. The aim of this work was to gain a better understanding of the antimicrobial mode of action of a phenols extract from olive vegetation water (PEOVW) at molecular level by studying Escherichia coli as a model microorganism. Genome-wide transcriptional analysis was performed on E. coli K-12 exposed to PEOVW. The repression of genes for flagellar synthesis and the involvement of genes linked to biofilm formation and stress response were observed. Sub-inhibitory concentrations of PEOVW significantly decreased biofilm formation, swarming and swimming motility, thus confirming the gene expression data. This study provides interesting insights on the molecular action of PEOVW on E. coli K-12. Given these anti-biofilm properties and considering that biofilm formation is a serious problem for the food industry and human health, PEOVW has proved to be a high-value natural product. Olive mill wastes are sources of phenolic compounds with a wide array of biological activities, including antimicrobial effects. Genome-wide transcriptional analysis was performed on E. coli K-12 exposed to phenols extract from olive vegetation water (PEOVW). Sub-inhibitory concentrations of PEOVW significantly decreased biofilm formation, swarming and swimming motility. Given these anti-biofilm properties PEOVW has proved to be a high-value natural product. PMID:24628798

  6. Mutation affecting regulation of synthesis of acetohydroxy acid synthetase in Escherichia coli K-12.

    PubMed Central

    Jackson, J H; Henderson, E K

    1975-01-01

    Altered regulation of synthesis of acetohydroxy acid synthetase (AHAS) was previously reported in a mutant of Escherichia coli strain K-12. The mutant strain, growing in minimal medium, exhibits a partial growth limiatation and derepression of AHAS, owing to deficient synthesis of isoleucine. The genetic lesion (ilvE503) causing the isoleucine limitation was shown to cause derepression of a valine-sensitive AHAS activity. The derepression effect of the ilvE503 mutation upon synthesis of AHAS was conclusively demonstrated by introducing both the ilvE503 allele and an altered AHAS (ilv-521) into the same cell. Evidence is presented that suggests the presence of multiple genetic regions for synthesis and control of the valine-sensitive AHAS activity. PMID:1089632

  7. The Crowded Sea: Incorporating Multiple Marine Activities in Conservation Plans Can Significantly Alter Spatial Priorities

    PubMed Central

    Mazor, Tessa; Possingham, Hugh P.; Edelist, Dori; Brokovich, Eran; Kark, Salit

    2014-01-01

    Successful implementation of marine conservation plans is largely inhibited by inadequate consideration of the broader social and economic context within which conservation operates. Marine waters and their biodiversity are shared by a host of stakeholders, such as commercial fishers, recreational users and offshore developers. Hence, to improve implementation success of conservation plans, we must incorporate other marine activities while explicitly examining trade-offs that may be required. In this study, we test how the inclusion of multiple marine activities can shape conservation plans. We used the entire Mediterranean territorial waters of Israel as a case study to compare four planning scenarios with increasing levels of complexity, where additional zones, threats and activities were added (e.g., commercial fisheries, hydrocarbon exploration interests, aquaculture, and shipping lanes). We applied the marine zoning decision support tool Marxan to each planning scenario and tested a) the ability of each scenario to reach biodiversity targets, b) the change in opportunity cost and c) the alteration of spatial conservation priorities. We found that by including increasing numbers of marine activities and zones in the planning process, greater compromises are required to reach conservation objectives. Complex plans with more activities incurred greater opportunity cost and did not reach biodiversity targets as easily as simplified plans with less marine activities. We discovered that including hydrocarbon data in the planning process significantly alters spatial priorities. For the territorial waters of Israel we found that in order to protect at least 10% of the range of 166 marine biodiversity features there would be a loss of ∼15% of annual commercial fishery revenue and ∼5% of prospective hydrocarbon revenue. This case study follows an illustrated framework for adopting a transparent systematic process to balance biodiversity goals and economic

  8. Mechanical Unloading of Mouse Bone in Microgravity Significantly Alters Cell Cycle Gene Set Expression

    NASA Astrophysics Data System (ADS)

    Blaber, Elizabeth; Dvorochkin, Natalya; Almeida, Eduardo; Kaplan, Warren; Burns, Brnedan

    2012-07-01

    Spaceflight factors, including microgravity and space radiation, have many detrimental short-term effects on human physiology, including muscle and bone degradation, and immune system dysfunction. The long-term progression of these physiological effects is still poorly understood, and a serious concern for long duration spaceflight missions. We hypothesized that some of the degenerative effects of spaceflight may be caused in part by an inability of stem cells to proliferate and differentiate normally resulting in an impairment of tissue regenerative processes. Furthermore, we hypothesized that long-term bone tissue degeneration in space may be mediated by activation of the p53 signaling network resulting in cell cycle arrest and/or apoptosis in osteoprogenitors. In our analyses we found that spaceflight caused significant bone loss in the weight-bearing bones of mice with a 6.3% reduction in bone volume and 11.9% decrease in bone thickness associated with increased osteoclastic activity. Along with this rapid bone loss we also observed alterations in the cell cycle characterized by an increase in the Cdkn1a/p21 cell cycle arrest molecule independent of Trp53. Overexpression of Cdkn1a/p21 was localized to osteoblasts lining the periosteal surface of the femur and chondrocytes in the head of the femur, suggesting an inhibition of proliferation in two key regenerative cell types of the femur in response to spaceflight. Additionally we found overexpression of several matrix degradation molecules including MMP-1a, 3 and 10, of which MMP-10 was localized to osteocytes within the shaft of the femur. This, in conjunction with 40 nm resolution synchrotron nano-Computed Tomography (nano-CT) observations of an increase in osteocyte lacunae cross-sectional area, perimeter and a decrease in circularity indicates a potential role for osteocytic osteolysis in the observed bone degeneration in spaceflight. To further investigate the genetic response of bone to mechanical

  9. Postranslational modifications significantly alter the binding-folding pathways of proteins associating with DNA

    NASA Astrophysics Data System (ADS)

    Papoian, Garegin

    2012-02-01

    Many important regulators of gene activity are natively disordered, but fully or partially order when they bind to their targets on DNA. Interestingly, the ensembles of disordered states for such free proteins are not structurally featureless, but can qualitatively differ from protein to protein. In particular, in random coil like states the chains are swollen, making relatively few contacts, while in molten globule like states a significant collapse occurs, with ensuing high density of intra-protein interactions. Furthermore, since many DNA binding proteins are positively charged polyelectrolytes, the electrostatic self-repulsion also influences the degree of collapse of the chain and its conformational preferences in the free state and upon binding to DNA. In our work, we have found that the nature of the natively disordered ensemble significantly affects the way the protein folds upon binding to DNA. In particular, we showed that posttranslational modifications of amino acid residues, such as lysine acetylation, can alter the degree of collapse and conformational preferences for a free protein, and also profoundly impact the binding affinity and pathways for the protein DNA association. These trends will be discussed in the context of DNA interacting with various histone tails and the p53 protein.

  10. Transcriptional responses of Escherichia coli K-12 and O157:H7 associated with lettuce leaves.

    PubMed

    Fink, Ryan C; Black, Elaine P; Hou, Zhe; Sugawara, Masayuki; Sadowsky, Michael J; Diez-Gonzalez, Francisco

    2012-03-01

    An increasing number of outbreaks of gastroenteritis recently caused by Escherichia coli O157:H7 have been linked to the consumption of leafy green vegetables. Although it is known that E. coli survives and grows in the phyllosphere of lettuce plants, the molecular mechanisms by which this bacterium associates with plants are largely unknown. The goal of this study was to identify E. coli genes relevant to its interaction, survival, or attachment to lettuce leaf surfaces, comparing E. coli K-12, a model system, and E. coli O157:H7, a pathogen associated with a large number of outbreaks. Using microarrays, we found that upon interaction with intact leaves, 10.1% and 8.7% of the 3,798 shared genes were differentially expressed in K-12 and O157:H7, respectively, whereas 3.1% changed transcript levels in both. The largest group of genes downregulated consisted of those involved in energy metabolism, including tnaA (33-fold change), encoding a tryptophanase that converts tryptophan into indole. Genes involved in biofilm modulation (bhsA and ybiM) and curli production (csgA and csgB) were significantly upregulated in E. coli K-12 and O157:H7. Both csgA and bhsA (ycfR) mutants were impaired in the long-term colonization of the leaf surface, but only csgA mutants had diminished ability in short-term attachment experiments. Our data suggested that the interaction of E. coli K-12 and O157:H7 with undamaged lettuce leaves likely is initiated via attachment to the leaf surface using curli fibers, a downward shift in their metabolism, and the suppression of biofilm formation.

  11. Telling Your Story: Ocean Scientists in the K-12 Classroom

    NASA Astrophysics Data System (ADS)

    McWilliams, H.

    2006-12-01

    Most scientists and engineers are accustomed to presenting their research to colleagues or lecturing college or graduate students. But if asked to speak in front of a classroom full of elementary school or junior high school students, many feel less comfortable. TERC, as part of its work with The Center for Ocean Sciences Education Excellence-New England (COSEE-NE) has designed a workshop to help ocean scientists and engineers develop skills for working with K-12 teachers and students. We call this program: Telling Your Story (TYS). TYS has been offered 4 times over 18 months for a total audience of approximately 50 ocean scientists. We will discuss the rationale for the program, the program outline, outcomes, and what we have learned. ne.net/edu_project_3/index.php

  12. K-12 students with concussions: a legal perspective.

    PubMed

    Zirkel, Perry A; Brown, Brenda Eagan

    2015-04-01

    This article provides a multipart analysis of the public schools' responsibility for students with concussions. The first part provides the prevailing diagnostic definitions of concussions and postconcussive syndrome. The second and central part provides (a) the legal framework of the two overlapping federal laws--the Individuals with Disabilities Education Act and Section 504 of the Rehabilitation Act and the varying state laws or local policies for individual health plans and (b) a summary of the developing body of hearing officer decisions, court decisions, and Office for Civil Rights rulings that have applied this framework to K-12 students with concussions. The final part offers recommendations for proactive return to school policies, with the school nurse playing a central supporting role.

  13. The complete genome sequence of Escherichia coli K-12.

    PubMed

    Blattner, F R; Plunkett, G; Bloch, C A; Perna, N T; Burland, V; Riley, M; Collado-Vides, J; Glasner, J D; Rode, C K; Mayhew, G F; Gregor, J; Davis, N W; Kirkpatrick, H A; Goeden, M A; Rose, D J; Mau, B; Shao, Y

    1997-09-01

    The 4,639,221-base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. The largest family of paralogous proteins contains 80 ABC transporters. The genome as a whole is strikingly organized with respect to the local direction of replication; guanines, oligonucleotides possibly related to replication and recombination, and most genes are so oriented. The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer. PMID:9278503

  14. K-12 access to internet: Securing the legal framework

    NASA Astrophysics Data System (ADS)

    Blauassociate, Andrew

    1993-09-01

    While many people in government, education, and industry have lauded the potential educational value of Internet access for students in grades K-12, there is as yet no legal or regulatory framework within which this new medium is being offered to students. The Communications Policy Forum, a nonpartisan project of the Electronic Frontier Foundation, recently convened a roundtable to discuss some of the legal issues that arise when K-12 schools provide Internet access to their students. Approximately 15 people, representing carriers who provide connections to the Internet, schools or school systems who are connected to the Internet, and legal experts with expertise in this and related areas, met to discuss questions of legal liability as this new medium enters an educational setting for minors. The following attempts to capture the major issues, suggestions, and directions for further collaborative efforts raised during the course of that discussion. In brief, the group identified statutory language aimed at other types of electronic communication that may offer some guidance; was briefed on a host of state laws that could be used to prosecute providers of certain materials found on the Internet; and concluded that there is no case law that clearly applies to this setting. The discussion revealed an interest in anticipating issues and developing responses before problems arose, and the need for shared approaches to allow carriers to move forward in serving and expanding this field. Members of the group offered to pursue these issues jointly and agreed upon a handful of concrete steps for further exploration and discussion.

  15. Supporting Geoscientists in Partnerships for K-12 Education at NSF

    NASA Astrophysics Data System (ADS)

    Leinen, M.

    2001-12-01

    NSF Directorate for Geosciences (GEO) education activities have evolved over the last decade based on advice from a broad segment of the geosciences community. These activities gained momentum when a Geosciences Education Working Group (GEWG, 1996) recognized the shift from traditional priorities that emphasized only research, to those that support education in geosciences as well. The GEWG report embraced this increased emphasis on education as a component of NSF's role in assuring the long-term health of the geosciences and endorsed the principle that research and education should be well integrated. While many geosciences education activities are funded by the Education and Human Resources Directorate (EHR) of NSF, the GEWG report highlighted the need to have more active participation by research geoscientists in K-12 education activities, and the need to train them to be able to do so. While some roles in education are clearly best left to educational professionals (e.g. large-scale systemic reform projects, pedagogical development at the K-12 level, and many teacher enhancement projects), activities such as undergraduate research, technology advancement, curriculum content development and informal science are ones in which GEO should actively seek to collaborate with programs in EHR. The GEO education program has expanded over the last decade. Our first education activity, Awards to Facilitate Geoscience Education (AFGE), was very successful in attracting some of the leading researchers in geosciences. This program evolved to become the Geoscience Education Program. An important program funded by GEO that developed from community activity is the Digital Library for Earth System Education (DLESE). This program grew out of a joint EHR/GEO award and a series of community workshops. The program will establish an Internet portal for geoscience curricular materials and other teacher resources that will enable further collaboration between the research and education

  16. The Aloha Telescope for K-12 STEM Education

    NASA Astrophysics Data System (ADS)

    Sowell, James R.

    2015-01-01

    How does one bring night-time astronomical observations into the classroom? How does a teacher - during the school day - show students the craters on the Moon, the rings of Saturn, or the four Galilean moons of Jupiter? One of the greatest drawbacks to teaching Astronomy is the lack of real-time telescopic observations during the school day, and yet this is a very exciting time for astronomical discoveries. The solution is to access a telescope in a substantially different time zone where it is still night. This facility - the Aloha Telescope - on Maui has already been established by a partnership between Georgia Tech and the Air Force Research Lab. This robotic telescope's sole purpose is for K-12 education, as it is equipped with a video-camera and is operated remotely via high-speed internet connections. This facility and its outreach program allow east-coast teachers and, in turn, students to have local daytime access to - and direct control of - the telescope. When observing the Moon, teachers and students will move the telescope wherever they wish across the highly-magnified lunar surface (~ 5 arcminute FOV). This telescope will enable night-time astronomical observations to come alive as day-time activities and will be an important tool for STEM education and activities. The use of the Aloha Telescope requires minimal training and is free after registering for a date and time.Dr. Sowell has written specific telescopic exercises and surface feature tours appropriate for K-12 and college-level users. These exercises, and other aspects of the Aloha Telescope and program, are posted on the website at http://aloha.gatech.edu

  17. How to Get Successfully Involved with K-12 Education

    NASA Astrophysics Data System (ADS)

    Duncan, D.; Fraknoi, A.; Bennett, M.

    1998-05-01

    Many astronomers now have some involvement in K-12 education, either through their children, through large projects with an education or outreach office, or through an educational component to their own grants. Some may need to incorporate education components into future proposals. For those new to education, it can be difficult to decide how best to use their limited resources without "re-inventing the wheel." Some astronomers are comfortable taking a direct role in the classroom or working with teachers, others prefer developing web-based or printed materials, while still others wouldrather work with local schools of education to enhance the training of future teachers. Which of these roles is most useful? In this session, participants will learn what has worked well in the past, with special attention paid to ways in which astronomers' and physicists' training and instincts may fail them when working in education. Invited teachers will describe their classrooms and how astronomers can be most helpful to them. Sample (successful) activities will be demonstrated, and information given about the wide range of existing astronomy and space-science education programs around the country. A full menu of useful ways that astronomers can get involved will be presented, as well as the organizations and institutions which can help in devising a meaningful education program. Handouts will include a catalog of national astronomy education projects, a list of educational web sites, information about the NASA OSS education brokers and facilitators, examples of successful educational materials, and a listing of roles astronomers have played or could play to enhance K-12 education. Registration is required; see the AAS Education WWW page or email aased@aas.org.

  18. Polymeric tannins significantly alter properties and in vitro digestibility of partially gelatinized intact starch granule.

    PubMed

    Amoako, Derrick B; Awika, Joseph M

    2016-10-01

    Excess calorie intake is a growing global problem. This study investigated effect of complexing partially gelatinized starch with condensed tannins on in vitro starch digestibility. Extracts from tannin and non-tannin sorghum, and cellulose control, were reacted with normal and waxy maize starch in 30% (30E) and 50% ethanol (50E) solutions at 70°C/20min. More tannins complexed with the 30E than 50E starches (mean 6.2 vs 3.5mg/g, respectively). In the 30E treatments, tannins significantly increased crystallinity, pasting temperature, peak viscosity, and slow digesting starch (from 100 to 274mg/g) in normal, but not waxy starch, suggesting intragranular cross-linking with amylose. Tannins doubled resistant starch (RS) to approx. 300mg/g in both starches. In 50E treatments, tannins made both maize starches behave like raw potato starch (>90% RS), suggesting granule surface interactions dominated. Non-tannin treatments generally behaved similar to cellulose. Condensed tannins could be used to favorably alter starch digestion profile.

  19. School-university partnership strategies for K--12 science education

    NASA Astrophysics Data System (ADS)

    Orcutt, Suzanne

    2002-09-01

    The purpose of this study was to identify and describe strategies for creating and sustaining school-university partnerships for K--12 science education. This descriptive study focused on the science partnership experience of two research universities and their K--12 partner schools. The study utilized a theoretical approach of "appreciative inquiry" and examined the following questions: (1) What are the characteristics and processes of school-university science partnerships that enable them to develop and sustain the partnership? (2) What are the characteristics and process of school-university science partnerships that hinder and limit the partnership? The researcher made on-site visits to each university to collect survey and interview data from a total of forty-nine participants within six school-university science partnerships. This study was not designed to be generalizable to other partnerships. Participants' responses were analyzed according to three partnership themes generated from the literature in order to frame this study: governance, collaboration, and change. Three key school-university science partnership strategies emerged from this analysis: linking science partnerships with the academic mission of the university, with the student services mission of the university, and with school reform efforts. Core research results included: participants concurred science is more peripheral than reading, language arts, and math content areas in current K--6 curriculum; the majority of respondents reported faculties' participation in school-university partnerships is sustainable when tied to their academic and research interests and rewarded with credit toward tenure; most participants reported science partnerships are sustainable when they create an aggregate for change. This study concludes that: Current school reform efforts need to focus on teaching more science, especially in the K--6 curriculum. For science partnerships to be sustainable, faculty

  20. K-12 Professional Development at the Harvard Forest LTER

    NASA Astrophysics Data System (ADS)

    Bennett, K.

    2012-12-01

    As part of the Long Term Ecological Research (LTER) program, the Harvard Forest in Petersham, Massachusetts seeks to train the next generation of researchers, by involving K-12 grade students and their teachers in hands-on, field-based, ecological research in their own schoolyard and community. Students learn to collect data on important long-term ecological issues and processes. Student data are then shared on the Harvard Forest website. To prepare teachers for project protocols, teachers are given direct access to Harvard ecologists with professional development workshops and on-line resources. With the Harvard Forest Schoolyard LTER program, students can participate in three different research projects focusing on phenology, invasive insects, and vernal pools. Teachers attend the Summer Institute for Teachers to learn project content and methods. They return in fall to participate in one of three levels of data workshops to learn how to input, manage, and analyze project data. In the spring, teachers again meet with the Harvard ecologists about project protocols, and to share, through a series of teacher presentations, the ways these project themes are being integrated into class curricula. These professional development opportunities result in long term collaborative partnerships with local schools and the Harvard Forest LTER. In addition to the LTER Schoolyard Ecology Program, the Harvard Forest has supported a successful Research Experience for Teachers (RET) program for the last six years. Throughout the summer, teachers work on research projects alongside Harvard Forest and affiliated scientists, post-docs, graduate students, and REU's (Research Experience for Undergraduates). The RET program provides teachers with the opportunity to build scientific knowledge, develop an understanding of research methods, and translate their new knowledge and experiences into cutting edge classroom lessons. The past two summers I have worked with Dr. Andrew Richardson

  1. Escherichia coli K-12 pathogenicity in the pea aphid, Acyrthosiphon pisum, reveals reduced antibacterial defense in aphids.

    PubMed

    Altincicek, Boran; Ter Braak, Bas; Laughton, Alice M; Udekwu, Klas I; Gerardo, Nicole M

    2011-10-01

    To better understand the molecular basis underlying aphid immune tolerance to beneficial bacteria and immune defense to pathogenic bacteria, we characterized how the pea aphid Acyrthosiphon pisum responds to Escherichia coli K-12 infections. E. coli bacteria, usually cleared in the hemolymph of other insect species, were capable of growing exponentially and killing aphids within a few days. Red fluorescence protein expressing E. coli K-12 laboratory strain multiplied in the aphid hemolymph as well as in the digestive tract, resulting in death of infected aphids. Selected gene deletion mutants of the E. coli K-12 predicted to have reduced virulence during systemic infections showed no difference in either replication or killing rate when compared to the wild type E. coli strain. Of note, however, the XL1-Blue E. coli K-12 strain exhibited a significant lag phase before multiplying and killing aphids. This bacterial strain has recently been shown to be more sensitive to oxidative stress than other E. coli K-12 strains, revealing a potential role for reactive oxygen species-mediated defenses in the otherwise reduced aphid immune system.

  2. Explorations in K-12 Education and Public Outreach

    NASA Astrophysics Data System (ADS)

    Limaye, S. S.; Pertzborn, R. A.; Sromovsky, L. A.

    1997-07-01

    Space exploration remains a topic of immense interest and excitement for children and the general public. A diverse approach has been utilized at the Space Science and Engineering Center to initiate outreach and K-12 education activities. The hands-on experience gained through a working relationships with educators has been useful in understanding the challenges, usefulness and limitations of scientists' involvement in the education process. Our efforts have included school visits, development of lesson plans (KidSat), internet based activities (Planet Exploration Toolkit for Live from Mars, a Passport to Knowledge Project), World Wide Web, Public Lectures, summer teacher enhancement workshops, internships, and substitute teaching in science classes. The feedback and comments from teachers and students has demonstrated the usefulness and need for these efforts. The experience has also demonstrated that a committed effort in outreach is ultimately satisfying although immensely time consuming. Our outreach efforts have been partially supported by a NASA/IDEA grant, Wisconsin Space Grant Consortium, NOAA and more recently, the Evjue Foundation (Madison-Wisconsin).

  3. Climate Change Webinars for K-12 Geoscience Educators

    NASA Astrophysics Data System (ADS)

    Henderson, S.; Johnson, R. M.; Gardiner, L. S.; Ward, D.; Russell, R. M.; Foster, S. Q.

    2009-12-01

    The Climate Change Educator Professional Development Network (CCEPDnet) is a new program from UCAR’s Office of Education and Outreach and Windows to the Universe. CCEPDnet was designed to improve teacher competency for global climate change education, building on proven existing resources, leveraging existing educator networks and an e-education approach. The project builds upon the successful set of online climate change education courses, NCAR Online Education: Climate Discovery (http://ecourses.ncar.ucar.edu/). CCEPDnet includes topical web seminars developed from these materials offered in collaboration with the National Science Teachers Association (NSTA). The project leverages teacher networks and publications available through NSTA, the National Earth Science Teachers Association (NESTA), Windows to the Universe (W2U), and other community based e-newsletters and list-serves to get the word out about the opportunity and build community. The goals of CCEPDnet are to: 1), Provide PD on climate change to a diverse group of middle and high school educators through web seminars; 2) effectively disseminate information about the opportunity to potential participants through a variety of venues; 3) evaluate the effectiveness of the web seminars and communicate the results; and 4) move the project to sustainability. This session will address best practices associated with the development of web seminars for K-12 educators and will discuss effective approaches to developing web seminars. CCEPNnet is funded by NASA.

  4. Earth System Science Online Courses for K-12 Teachers

    NASA Astrophysics Data System (ADS)

    Schwerin, T. G.

    2001-05-01

    The Earth System Science Education Alliance (ESSEA) is a partnership between the Institute for Global Environmental Strategies (IGES) and the Center for Educational Technologies (CET) at Wheeling Jesuit University, through funding from NASA's Earth Science Enterprise. ESSEA is supporting universities, colleges, and science education organizations in offering K-12 Earth system science online graduate courses that have been developed within the CET at Wheeling Jesuit University for NASA's Earth Science Enterprise. The Earth system science courses use an inquiry-based instructional design model, are delivered over the Internet, and feature student-centered, knowledge-building virtual communities. They have been successfully implemented for both in-service and pre-service teacher education. An annual announcement by ESSEA solicits proposals from US teams interested in offering the courses. Currently 12 institutions from across the US are offering the courses to teachers, with plans to select 7 new organizations in early 2001. This presentation will focus on the content and structure of the courses, which can be freely downloaded and used by any organization, as well as lessons learned about online instruction.

  5. "Flipping" educational technology professional development for K-12 educators

    NASA Astrophysics Data System (ADS)

    Spencer, Daniel

    As the demand for more effective professional development increases in K-12 schools, trainers must adjust their training methods to meet the needs of their teacher learners. Just as lecture-heavy, teacher-centered instruction only meet the learning needs of a small minority of students, "sit and get" professional development rarely results in the teachers gaining the skills and confidence necessary to use technology effectively in their instruction. To resolve the frustrations of teachers related to ineffective professional development, a "Flipped PD" training model was developed based on the learning needs of adult learners, the integration of technological, pedagogical, and content knowledge (TPACK), learning activities, and the Flipped Classroom concept. Under this model, training shifts from a passive, trainer-centered format, to an active, learner-centered format where teachers learn to use technology in their classrooms by first focusing on pedagogical issues, then choosing the options that work best for addressing those issues in their unique situation, and completing "learn-by-doing" projects. Those who participate in "Flipped PD" style trainings tend to have more confidence upon completion that they can use the tools they were trained on in their teaching, as well as believe that the PD was engaging and a good use of their time.

  6. Reductive dehalogenation of carbon tetrachloride by Escherichia coli K-12.

    PubMed Central

    Criddle, C S; DeWitt, J T; McCarty, P L

    1990-01-01

    The formation of radicals from carbon tetrachloride (CT) is often invoked to explain the product distribution resulting from its transformation. Radicals formed by reduction of CT presumably react with constituents of the surrounding milieu to give the observed product distribution. The patterns of transformation observed in this work were consistent with such a hypothesis. In cultures of Escherichia coli K-12, the pathways and rates of CT transformation were dependent on the electron acceptor condition of the media. Use of oxygen and nitrate as electron acceptors generally prevented CT metabolism. At low oxygen levels (approximately 1%), however, transformation of [14C]CT to 14CO2 and attachment to cell material did occur, in accord with reports of CT fate in mammalian cell cultures. Under fumarate-respiring conditions, [14C]CT was recovered as 14CO2, chloroform, and a nonvolatile fraction. In contrast, fermenting conditions resulted in more chloroform, more cell-bound 14C, and almost no 14CO2. Rates of transformation of CT were faster under fermenting conditions than under fumarate-respiring conditions. Transformation rates also decreased over time, suggesting the gradual exhaustion of transformation activity. This loss was modeled with a simple exponential decay term. PMID:2268147

  7. GeoWall Experiences in K-12 Education

    NASA Astrophysics Data System (ADS)

    Johnson, A. E.

    2003-12-01

    Since the mid 1990s the Electronic Visualization Laboratory at the University of Illinois at Chicago has been investigating how advanced visualization technology such as CAVEs, ImmersaDesks, PCs, and plasma panels can be used effectively in K-12 education. The creation of the GeoWall has given us more flexibility in deploying these technologies, and conducting these investigations outside the laboratory. Over the two years we have been using GeoWalls in a variety of educational settings around the Chicago area. Since the Fall of 2002, the SciTech Museum in Aurora, IL has used a GeoWall to show a variety of educational content. In February 2002 the Museum of Science and Industry in Chicago, IL set up a GeoWall to show 'Virtual Harlem' which allowed museum patrons to walk the streets of Harlem NY in the 1930s to learn about the place and the people. Since 1999 we have been working with Abraham Lincoln Elementary School in Oak Park, IL using a variety of display devices to teach the scientific method and investigate the use of multiple perspectives in learning. We began using a GeoWall there in the spring of 2002 and in the spring of 2003 we expanded our work in Oak Park to include Gwendolyn Brooks Middle School.

  8. Urinary Collagen Fragments Are Significantly Altered in Diabetes: A Link to Pathophysiology

    PubMed Central

    Argilés, Àngel; Cerna, Marie; Delles, Christian; Dominiczak, Anna F.; Gayrard, Nathalie; Iphöfer, Alexander; Jänsch, Lothar; Jerums, George; Medek, Karel; Mischak, Harald; Navis, Gerjan J.; Roob, Johannes M.; Rossing, Kasper; Rossing, Peter; Rychlík, Ivan; Schiffer, Eric; Schmieder, Roland E.; Wascher, Thomas C.; Winklhofer-Roob, Brigitte M.; Zimmerli, Lukas U.; Zürbig, Petra; Snell-Bergeon, Janet K.

    2010-01-01

    Background The pathogenesis of diabetes mellitus (DM) is variable, comprising different inflammatory and immune responses. Proteome analysis holds the promise of delivering insight into the pathophysiological changes associated with diabetes. Recently, we identified and validated urinary proteomics biomarkers for diabetes. Based on these initial findings, we aimed to further validate urinary proteomics biomarkers specific for diabetes in general, and particularity associated with either type 1 (T1D) or type 2 diabetes (T2D). Methodology/Principal Findings Therefore, the low-molecular-weight urinary proteome of 902 subjects from 10 different centers, 315 controls and 587 patients with T1D (n = 299) or T2D (n = 288), was analyzed using capillary-electrophoresis mass-spectrometry. The 261 urinary biomarkers (100 were sequenced) previously discovered in 205 subjects were validated in an additional 697 subjects to distinguish DM subjects (n = 382) from control subjects (n = 315) with 94% (95% CI: 92–95) accuracy in this study. To identify biomarkers that differentiate T1D from T2D, a subset of normoalbuminuric patients with T1D (n = 68) and T2D (n = 42) was employed, enabling identification of 131 biomarker candidates (40 were sequenced) differentially regulated between T1D and T2D. These biomarkers distinguished T1D from T2D in an independent validation set of normoalbuminuric patients (n = 108) with 88% (95% CI: 81–94%) accuracy, and in patients with impaired renal function (n = 369) with 85% (95% CI: 81–88%) accuracy. Specific collagen fragments were associated with diabetes and type of diabetes indicating changes in collagen turnover and extracellular matrix as one hallmark of the molecular pathophysiology of diabetes. Additional biomarkers including inflammatory processes and pro-thrombotic alterations were observed. Conclusions/Significance These findings, based on the largest proteomic study performed to date on subjects with

  9. K-12 Education Nonprofit Employees' Perceptions of Strategies for Recruiting and Retaining Employees

    ERIC Educational Resources Information Center

    Byrne, Tara Marie

    2013-01-01

    This qualitative study explored the key reasons individuals who work in K-12 education nonprofit organizations enter the field of K-12 nonprofit education and their motivations for doing so. The purpose of this study was to find new strategies for recruiting and retaining K-12 education nonprofit employees by examining the obstacles that exist to…

  10. Research and Practice in K-12 Online Learning: A Review of Open Access Literature

    ERIC Educational Resources Information Center

    Cavanaugh, Cathy S.; Barbour, Michael K.; Clark, Tom

    2009-01-01

    The literature related to online learning programs for K-12 students dates to the mid-1990s and builds upon a century of research and practice from K-12 distance education. While K-12 online learning programs have evolved and grown over the past decade, the amount of published research on virtual schooling practice and policy is limited. The…

  11. What Do Indiana Voters Say about K-12 Education & School Choice? Executive Summary

    ERIC Educational Resources Information Center

    Foundation for Educational Choice, 2010

    2010-01-01

    The "Indiana K-12 & School Choice Survey" project, commissioned by The Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Indiana registered voters' awareness and opinions on a range of K-12 education issues. "What Do Indiana Voters Say about K-12 Education & School Choice?" reports the "levels" and…

  12. Finished Genome Sequence of the Laboratory Strain Escherichia coli K-12 RV308 (ATCC 31608).

    PubMed

    Krempl, Peter M; Mairhofer, Juergen; Striedner, Gerald; Thallinger, Gerhard G

    2014-11-20

    Escherichia coli strain K-12 substrain RV308 is an engineered descendant of the K-12 wild-type strain. Like its ancestor, it is an important organism in biotechnological research and is heavily used for the expression of single-chain variable fragments. Here, we report the complete genome sequence of E. coli K-12 RV308 (ATCC 31608).

  13. Interview with Joe Freidhoff: A Bird's-Eye View of K-12 Online Learning

    ERIC Educational Resources Information Center

    Pourreau, Leslie

    2015-01-01

    The intent of this article is to introduce long-time "Online Learning" readership to the field of K-12 online learning while also providing direction for the K-12 online learning scholars about where the field is going or should be going in terms of meeting the needs of K-12 stakeholders. Recently an interview was conducted with Dr. Joe…

  14. Harnessing Technology to Improve K-12 Education. Discussion Paper 2012-05

    ERIC Educational Resources Information Center

    Chatterji, Aaron; Jones, Benjamin

    2012-01-01

    Technological progress has consistently driven remarkable advances in the U.S. economy, yet K-12 education sees little technological change compared to other sectors, even as U.S. K-12 students increasingly lag behind students in other nations. This proposal considers how we can take a signature American strength--innovation--and apply it to K-12

  15. Effect of Streptococcus salivarius K12 on the in vitro growth of Candida albicans and its protective effect in an oral candidiasis model.

    PubMed

    Ishijima, Sanae A; Hayama, Kazumi; Burton, Jeremy P; Reid, Gregor; Okada, Masashi; Matsushita, Yuji; Abe, Shigeru

    2012-04-01

    Oral candidiasis is often accompanied by severe inflammation, resulting in a decline in the quality of life of immunosuppressed individuals and elderly people. To develop a new oral therapeutic option for candidiasis, a nonpathogenic commensal oral probiotic microorganism, Streptococcus salivarius K12, was evaluated for its ability to modulate Candida albicans growth in vitro, and its therapeutic activity in an experimental oral candidiasis model was tested. In vitro inhibition of mycelial growth of C. albicans was determined by plate assay and fluorescence microscopy. Addition of S. salivarius K12 to modified RPMI 1640 culture medium inhibited the adherence of C. albicans to the plastic petri dish in a dose-dependent manner. Preculture of S. salivarius K12 potentiated its inhibitory activity for adherence of C. albicans. Interestingly, S. salivarius K12 was not directly fungicidal but appeared to inhibit Candida adhesion to the substratum by preferentially binding to hyphae rather than yeast. To determine the potentially anti-infective attributes of S. salivarius K12 in oral candidiasis, the probiotic was administered to mice with orally induced candidiasis. Oral treatment with S. salivarius K12 significantly protected the mice from severe candidiasis. These findings suggest that S. salivarius K12 may inhibit the process of invasion of C. albicans into mucous surfaces or its adhesion to denture acrylic resins by mechanisms not associated with the antimicrobial activity of the bacteriocin. S. salivarius K12 may be useful as a probiotic as a protective tool for oral care, especially with regard to candidiasis. PMID:22267663

  16. Effect of Streptococcus salivarius K12 on the In Vitro Growth of Candida albicans and Its Protective Effect in an Oral Candidiasis Model

    PubMed Central

    Hayama, Kazumi; Burton, Jeremy P.; Reid, Gregor; Okada, Masashi; Matsushita, Yuji; Abe, Shigeru

    2012-01-01

    Oral candidiasis is often accompanied by severe inflammation, resulting in a decline in the quality of life of immunosuppressed individuals and elderly people. To develop a new oral therapeutic option for candidiasis, a nonpathogenic commensal oral probiotic microorganism, Streptococcus salivarius K12, was evaluated for its ability to modulate Candida albicans growth in vitro, and its therapeutic activity in an experimental oral candidiasis model was tested. In vitro inhibition of mycelial growth of C. albicans was determined by plate assay and fluorescence microscopy. Addition of S. salivarius K12 to modified RPMI 1640 culture medium inhibited the adherence of C. albicans to the plastic petri dish in a dose-dependent manner. Preculture of S. salivarius K12 potentiated its inhibitory activity for adherence of C. albicans. Interestingly, S. salivarius K12 was not directly fungicidal but appeared to inhibit Candida adhesion to the substratum by preferentially binding to hyphae rather than yeast. To determine the potentially anti-infective attributes of S. salivarius K12 in oral candidiasis, the probiotic was administered to mice with orally induced candidiasis. Oral treatment with S. salivarius K12 significantly protected the mice from severe candidiasis. These findings suggest that S. salivarius K12 may inhibit the process of invasion of C. albicans into mucous surfaces or its adhesion to denture acrylic resins by mechanisms not associated with the antimicrobial activity of the bacteriocin. S. salivarius K12 may be useful as a probiotic as a protective tool for oral care, especially with regard to candidiasis. PMID:22267663

  17. Effect of Streptococcus salivarius K12 on the in vitro growth of Candida albicans and its protective effect in an oral candidiasis model.

    PubMed

    Ishijima, Sanae A; Hayama, Kazumi; Burton, Jeremy P; Reid, Gregor; Okada, Masashi; Matsushita, Yuji; Abe, Shigeru

    2012-04-01

    Oral candidiasis is often accompanied by severe inflammation, resulting in a decline in the quality of life of immunosuppressed individuals and elderly people. To develop a new oral therapeutic option for candidiasis, a nonpathogenic commensal oral probiotic microorganism, Streptococcus salivarius K12, was evaluated for its ability to modulate Candida albicans growth in vitro, and its therapeutic activity in an experimental oral candidiasis model was tested. In vitro inhibition of mycelial growth of C. albicans was determined by plate assay and fluorescence microscopy. Addition of S. salivarius K12 to modified RPMI 1640 culture medium inhibited the adherence of C. albicans to the plastic petri dish in a dose-dependent manner. Preculture of S. salivarius K12 potentiated its inhibitory activity for adherence of C. albicans. Interestingly, S. salivarius K12 was not directly fungicidal but appeared to inhibit Candida adhesion to the substratum by preferentially binding to hyphae rather than yeast. To determine the potentially anti-infective attributes of S. salivarius K12 in oral candidiasis, the probiotic was administered to mice with orally induced candidiasis. Oral treatment with S. salivarius K12 significantly protected the mice from severe candidiasis. These findings suggest that S. salivarius K12 may inhibit the process of invasion of C. albicans into mucous surfaces or its adhesion to denture acrylic resins by mechanisms not associated with the antimicrobial activity of the bacteriocin. S. salivarius K12 may be useful as a probiotic as a protective tool for oral care, especially with regard to candidiasis.

  18. K-12 Teachers Encounter Digital Games: A Qualitative Investigation of Teachers' Perceptions of the Potential of Digital Games for K-12 Education

    ERIC Educational Resources Information Center

    Dickey, Michele D.

    2015-01-01

    The purpose of this study is to investigate teachers' perceptions of the integration of digital games for K-12 education. Specifically, this qualitative investigation focuses on reflective dialogued gathered from a group of K-12 educators about their experiences and perceptions of learning about and playing digital games for teaching and learning.…

  19. The Pragmatics of Virtual Worlds for K-12 Educators: Investigating the Affordances and Constraints of "Active Worlds" and "Second Life" with K-12 In-Service Teachers

    ERIC Educational Resources Information Center

    Dickey, Michele D.

    2011-01-01

    The purpose of this study is to address the pragmatics of integrating virtual worlds for teaching and learning for K-12 education. Specifically this qualitative investigation focuses on a reflective dialogue gathered from a group of K-12 (primary and secondary school) educators about their experiences using both "Active Worlds Educational…

  20. New pleiotropic alkaline phosphatase-negative mutants of Escherichia coli K-12.

    PubMed Central

    Heyde, M; Portalier, R

    1982-01-01

    Escherichia coli K-12 mutants showing reduced alkaline phosphatase activity were isolated as 5-fluorouracil-plus-adenosine-resistant derivatives of a upp pho (either phoS or phoT) strain. One class of these mutants displayed a temperature-sensitive alkaline phosphatase-negative phenotype, a pleiotropic defect for growth on some substrates, an increased sensitivity to toxic compounds (e.g., EDTA, mitomycin, and chloramphenicol), and alterations in the expression of some membrane proteins. It phenotypically differed from previously described mutants. The mutation was located at min 8.5 close to the phoA gene and defines a new genetic locus we called napA (for negative alkaline phosphatase pleiotropic phenotype). As these mutants have lost the ability to grow on lactose and galactose, Lac+ and Gal+ revertants were isolated that simultaneously recovered the parental phenotype. PMID:7047492

  1. Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance.

    PubMed

    Saunus, Jodi M; Quinn, Michael C J; Patch, Ann-Marie; Pearson, John V; Bailey, Peter J; Nones, Katia; McCart Reed, Amy E; Miller, David; Wilson, Peter J; Al-Ejeh, Fares; Mariasegaram, Mythily; Lau, Queenie; Withers, Teresa; Jeffree, Rosalind L; Reid, Lynne E; Da Silva, Leonard; Matsika, Admire; Niland, Colleen M; Cummings, Margaret C; Bruxner, Timothy J C; Christ, Angelika N; Harliwong, Ivon; Idrisoglu, Senel; Manning, Suzanne; Nourse, Craig; Nourbakhsh, Ehsan; Wani, Shivangi; Anderson, Matthew J; Fink, J Lynn; Holmes, Oliver; Kazakoff, Stephen; Leonard, Conrad; Newell, Felicity; Taylor, Darrin; Waddell, Nick; Wood, Scott; Xu, Qinying; Kassahn, Karin S; Narayanan, Vairavan; Taib, Nur Aishah; Teo, Soo-Hwang; Chow, Yock Ping; kConFab; Jat, Parmjit S; Brandner, Sebastian; Flanagan, Adrienne M; Khanna, Kum Kum; Chenevix-Trench, Georgia; Grimmond, Sean M; Simpson, Peter T; Waddell, Nicola; Lakhani, Sunil R

    2015-11-01

    Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality rate is virtually 100%. Targeted therapy is critically under-utilized, and our understanding of mechanisms underpinning metastatic outgrowth in the brain is limited. To address these deficiencies, we investigated the genomic and transcriptomic landscapes of 36 BMs from breast, lung, melanoma and oesophageal cancers, using DNA copy-number analysis and exome- and RNA-sequencing. The key findings were as follows. (a) Identification of novel candidates with possible roles in BM development, including the significantly mutated genes DSC2, ST7, PIK3R1 and SMC5, and the DNA repair, ERBB-HER signalling, axon guidance and protein kinase-A signalling pathways. (b) Mutational signature analysis was applied to successfully identify the primary cancer type for two BMs with unknown origins. (c) Actionable genomic alterations were identified in 31/36 BMs (86%); in one case we retrospectively identified ERBB2 amplification representing apparent HER2 status conversion, then confirmed progressive enrichment for HER2-positivity across four consecutive metastatic deposits by IHC and SISH, resulting in the deployment of HER2-targeted therapy for the patient. (d) In the ERBB/HER pathway, ERBB2 expression correlated with ERBB3 (r(2)  = 0.496; p < 0.0001) and HER3 and HER4 were frequently activated in an independent cohort of 167 archival BM from seven primary cancer types: 57.6% and 52.6% of cases were phospho-HER3(Y1222) or phospho-HER4(Y1162) membrane-positive, respectively. The HER3 ligands NRG1/2 were barely detectable by RNAseq, with NRG1 (8p12) genomic loss in 63.6% breast cancer-BMs, suggesting a microenvironmental source of ligand. In summary, this is the first study to characterize the genomic landscapes of BM. The data revealed novel candidates, potential clinical applications for genomic profiling of resectable BMs, and highlighted the possibility of therapeutically targeting

  2. Linkage map of Escherichia coli K-12, edition 8.

    PubMed Central

    Bachmann, B J

    1990-01-01

    The linkage map of Escherichia coli K-12 depicts the arrangement of genes on the circular chromosome of this organism. The basic units of the map are minutes, determined by the time-of-entry of markers from Hfr into F- strains in interrupted-conjugation experiments. The time-of-entry distances have been refined over the years by determination of the frequency of cotransduction of loci in transduction experiments utilizing bacteriophage P1, which transduces segments of DNA approximately 2 min in length. In recent years, the relative positions of many genes have been determined even more precisely by physical techniques, including the mapping of restriction fragments and the sequencing of many small regions of the chromosome. On the whole, the agreement between results obtained by genetic and physical methods has been remarkably good considering the different levels of accuracy to be expected of the methods used. There are now few regions of the map whose length is still in some doubt. In some regions, genetic experiments utilizing different mutant strains give different map distances. In other regions, the genetic markers available have not been close enough to give accurate cotransduction data. The chromosome is now known to contain several inserted elements apparently derived from lambdoid phages and other sources. The nature of the region in which the termination of replication of the chromosome occurs is now known to be much more complex than the picture given in the previous map. The present map is based upon the published literature through June of 1988. There are now 1,403 loci placed on the linkage group, which may represent between one-third and one-half of the genes in this organism. PMID:2194094

  3. Teaching Decolonial Sounds on the Margins: Reflections on a K-12 Teacher Workshop Covering Black & Brown Musical Transculturation in Texas

    ERIC Educational Resources Information Center

    Cervantes, Marco Antonio

    2015-01-01

    To demonstrate the significance of cultural crossings in Texas and how cultural exchanges can inform teachers and students in the areas of history, fine arts, geography, and social studies, the author constructed a Summer 2013 teacher workshop for Texas K-12 teachers through the Smithsonian Affiliated Institute of Texan Cultures. The author…

  4. Descriptors for Psychological Understanding: A Guide to Asking Questions about Learning related to Psychology in Wisconsin Schools, K-12.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Social Studies Curriculum Study Committee.

    Statements of learning objectives are provided to help clarify and direct the teaching of psychology in Wisconsin schools and to help educators identify the most significant ideas in the discipline which should be incorporated into the K-12 curriculum. These statements, or "descriptors," were developed after the State of Wisconsin Social Studies…

  5. School Counselors' Systematic Perceptions of Change Agency through Primal Leadership and Empowerment: Critical Provisions towards K-12 Students' Achievement

    ERIC Educational Resources Information Center

    Fay, Miriam Soler; Martin, Barbara Nell

    2005-01-01

    In this examination, 194 K-12 school counselors completed the Self-Perceptions of Effectiveness as Educational Change Agent (SPECA) survey. Analyses uncovered that Primal Leadership and personal power or empowerment both play a significant role in counselors' potential effectiveness to effect change regardless of gender or building level. Personal…

  6. Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children

    PubMed Central

    Di Pierro, Francesco; Colombo, Maria; Zanvit, Alberto; Risso, Paolo; Rottoli, Amilcare S

    2014-01-01

    Background Streptococcus salivarius K12 is an oral probiotic strain releasing two lantibiotics (salivaricin A2 and salivaricin B) that antagonize the growth of S. pyogenes, the most important bacterial cause of pharyngeal infections in humans also affected by episodes of acute otitis media. S. salivarius K12 successfully colonizes the oral cavity, and is endowed with an excellent safety profile. We tested its preventive role in reducing the incidence of both streptococcal and viral pharyngitis and/or tonsillitis in children. Materials and methods We enrolled 61 children with a diagnosis of recurrent oral streptococcal disorders. Thirty-one of them were enrolled to be treated daily for 90 days with a slow-release tablet for oral use, containing no less than 1 billion colony-forming units/tablet of S. salivarius K12 (Bactoblis®), and the remaining 30 served as the untreated control group. During treatment, they were all examined for streptococcal infection. Twenty children (ten per group) were also assessed in terms of viral infection. Secondary end points in both groups were the number of days under antibiotic and antipyretic therapy and the number of days off school (children) and off work (parents). Results The 30 children who completed the 90-day trial with Bactoblis® showed a significant reduction in their episodes of streptococcal pharyngeal infection (>90%), as calculated by comparing the infection rates of the previous year. No difference was observed in the control group. The treated group showed a significant decrease in the incidence (80%) of oral viral infections. Again, there was no difference in the control group. With regard to secondary end points, the number of days under antibiotic treatment of the treated and control groups were 30 and 900 respectively, days under antipyretic treatment 16 and 228, days of absence from school 16 and 228, and days of absence from work 16 and 228. The product was well tolerated by the subjects, with no side effects

  7. Sense and Sensibility: The Case for the Nationwide Inclusion of Engineering in the K-12 Curriculum

    NASA Technical Reports Server (NTRS)

    Lindberg, Robert E.; Pinelli, Thomas E.; Batterson, James G.

    2008-01-01

    The competitive status of the United States is inextricably linked to innovation just as innovation is inseparable from science, technology, engineering, and mathematics. To stay competitive in innovation requires that the United States produce a 21st century workforce complete with requisite education, training, skills, and motivation. If we accept a priori that science, technology, engineering, and mathematics education are crucial to competitiveness and innovation and that, in terms of innovation, mathematics, science, and engineering are interdependent, why are mathematics and science uniformly ubiquitous in the K-12 curriculum while engineering is conspicuously absent? We are passionate in our belief that the uniform addition of engineering to the K-12 curriculum will help ensure that the nation has "the right" 21st Century workforce. Furthermore, we believe that a nationwide effort, led by a coalition of engineering academics, practitioners, and societies is required to turn this goal into reality. However, accomplishing this goal necessitates, as we are reminded by the title of Jane Austen's timeless novel, "Sense and Sensibility", a workable solution that seeks the "middle ground" between passion and reason. We begin our paper by making two essential points: Engineers are not scientists. Engineering exists separate from science, has its own specialized knowledge community apart from science, and it is largely responsible for many of the most significant advancements and improvements in the quality of our life. Our workable solution requires that K-12 education, nationwide, accommodate the inclusion of engineering as a stand alone curriculum and we offer three reasons to support our position: (1) workforce development, (2) stimulating interest in STEM (science, technology, engineering, and mathematics) courses and careers, and (3) creating a technologically literate society. We conclude with some thoughts on how this important goal can be accomplished.

  8. K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience

    PubMed Central

    Deal, Alex L.; Erickson, Kristen J.; Bilsky, Edward J.; Hillman, Susan J.; Burman, Michael A.

    2014-01-01

    The University of New England’s Center for Excellence in the Neurosciences has developed a successful and growing K-12 outreach program that incorporates undergraduate and graduate/professional students. The program has several goals, including raising awareness about fundamental issues in neuroscience, supplementing science education in area schools and enhancing undergraduate and graduate/professional students’ academic knowledge and skill set. The outreach curriculum is centered on core neuroscience themes including: Brain Safety, Neuroanatomy, Drugs of Abuse and Addiction, Neurological and Psychiatric Disorders, and Cognition and Brain Function. For each theme, lesson plans were developed based upon interactive, small-group activities. Additionally, we’ve organized our themes in a “Grow-up, Grow-out” approach. Grow-up refers to returning to a common theme, increasing in complexity as we revisit students from early elementary through high school. Grow-out refers to integrating other scientific fields into our lessons, such as the chemistry of addiction, the physics of brain injury and neuronal imaging. One of the more successful components of our program is our innovative team-based model of curriculum design. By creating a team of undergraduate, graduate/professional students and faculty, we create a unique multi-level mentoring opportunity that appears to be successful in enhancing undergraduate students’ skills and knowledge. Preliminary assessments suggest that undergraduates believe they are enhancing their content knowledge and professional skills through our program. Additionally, we’re having a significant, short-term impact on K-12 interest in science. Overall, our program appears to be enhancing the academic experience of our undergraduates and exciting K-12 students about the brain and science in general. PMID:25565921

  9. K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience.

    PubMed

    Deal, Alex L; Erickson, Kristen J; Bilsky, Edward J; Hillman, Susan J; Burman, Michael A

    2014-01-01

    The University of New England's Center for Excellence in the Neurosciences has developed a successful and growing K-12 outreach program that incorporates undergraduate and graduate/professional students. The program has several goals, including raising awareness about fundamental issues in neuroscience, supplementing science education in area schools and enhancing undergraduate and graduate/professional students' academic knowledge and skill set. The outreach curriculum is centered on core neuroscience themes including: Brain Safety, Neuroanatomy, Drugs of Abuse and Addiction, Neurological and Psychiatric Disorders, and Cognition and Brain Function. For each theme, lesson plans were developed based upon interactive, small-group activities. Additionally, we've organized our themes in a "Grow-up, Grow-out" approach. Grow-up refers to returning to a common theme, increasing in complexity as we revisit students from early elementary through high school. Grow-out refers to integrating other scientific fields into our lessons, such as the chemistry of addiction, the physics of brain injury and neuronal imaging. One of the more successful components of our program is our innovative team-based model of curriculum design. By creating a team of undergraduate, graduate/professional students and faculty, we create a unique multi-level mentoring opportunity that appears to be successful in enhancing undergraduate students' skills and knowledge. Preliminary assessments suggest that undergraduates believe they are enhancing their content knowledge and professional skills through our program. Additionally, we're having a significant, short-term impact on K-12 interest in science. Overall, our program appears to be enhancing the academic experience of our undergraduates and exciting K-12 students about the brain and science in general. PMID:25565921

  10. K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience.

    PubMed

    Deal, Alex L; Erickson, Kristen J; Bilsky, Edward J; Hillman, Susan J; Burman, Michael A

    2014-01-01

    The University of New England's Center for Excellence in the Neurosciences has developed a successful and growing K-12 outreach program that incorporates undergraduate and graduate/professional students. The program has several goals, including raising awareness about fundamental issues in neuroscience, supplementing science education in area schools and enhancing undergraduate and graduate/professional students' academic knowledge and skill set. The outreach curriculum is centered on core neuroscience themes including: Brain Safety, Neuroanatomy, Drugs of Abuse and Addiction, Neurological and Psychiatric Disorders, and Cognition and Brain Function. For each theme, lesson plans were developed based upon interactive, small-group activities. Additionally, we've organized our themes in a "Grow-up, Grow-out" approach. Grow-up refers to returning to a common theme, increasing in complexity as we revisit students from early elementary through high school. Grow-out refers to integrating other scientific fields into our lessons, such as the chemistry of addiction, the physics of brain injury and neuronal imaging. One of the more successful components of our program is our innovative team-based model of curriculum design. By creating a team of undergraduate, graduate/professional students and faculty, we create a unique multi-level mentoring opportunity that appears to be successful in enhancing undergraduate students' skills and knowledge. Preliminary assessments suggest that undergraduates believe they are enhancing their content knowledge and professional skills through our program. Additionally, we're having a significant, short-term impact on K-12 interest in science. Overall, our program appears to be enhancing the academic experience of our undergraduates and exciting K-12 students about the brain and science in general.

  11. Epigenetic alterations in head and neck cancer: prevalence, clinical significance, and implications.

    PubMed

    Fan, Chun-Yang

    2004-03-01

    Head and neck cancers are a group of malignancies with diverse biologic behaviors and a strong, well-established association with tobacco and alcohol use. Although the hunt for genetic alterations in head and neck cancer has continued in the past two decades, with unequivocal proof of a genetic role in multistage head and neck carcinogenesis, epigenetic alteration in association with promoter CpG island hypermethylation has emerged in the past few years as one of the most active areas of cancer research. It is now firmly believed that, in cancer cells, promoter CpG island hypermethylation (epigenetic alteration) represents a bona fide alternative mechanism, as opposed to genetic factors, such as gene mutations and deletion, in the inactivation of many tumor-suppressor genes. It is also realized that epigenetic and genetic factors often work together, affecting multiple cellular pathways, such as cell-cycle regulation, DNA repair, apoptosis, angiogenesis, and cell-to-cell adhesion, during the process of tumor growth and progression.

  12. Cool Science: K-12 Climate Change Art Displayed on Buses

    NASA Astrophysics Data System (ADS)

    Chen, R. F.; Lustick, D. S.; Lohmeier, J.; Thompson, S. R.

    2015-12-01

    Cool science is an art contest where K12 students create placards (7" x 22") to educate the public about climate change. Students are prompted to create their artwork in response to questions such as: What is the evidence for climate change? How does climate change impact your local community? What can you do to reduce the impacts of climate change? In each of three years, 500-600 student entrees have been submitted from more than 12 school districts across Massachusetts. A panel of judges including scientists, artists, rapid transit representatives, and educators chooses elementary, middle, and high school winners. Winners (6), runners-up (6), and honorable mentions (12) and their families and teachers are invited to an annual Cool Science Award Ceremony to be recognized and view winning artwork. All winning artwork is posted on the Cool Science website. The winning artwork (2 per grade band) is converted into placards (11" x 28") and posters (2.5' x 12') that are placed on the inside (placards) and outside (posters) of buses. Posters are displayed for one month. So far, Cool Science was implemented in Lowell, MA where over 5000 public viewers see the posters daily on the sides of Lowell Rapid Transit Authority (LRTA) buses, making approximately 1,000,000 impressions per year. Cool Science acts to increase climate literacy in children as well as the public, and as such promotes intergenerational learning. Using art in conjunction with science learning about climate change appears to be effective at engaging not just traditionally high achieving science students, but also those interested in the creative arts. Hearing winners' stories about how they created their artwork and what this contest meant to them supports the idea that Cool Science attracts a wide diversity of students. Parents discuss climate change with their children. Multiple press releases announcing the winners further promotes the awareness of climate change throughout school districts and their

  13. Lecture Demonstrations on Earthquakes for K-12 Teachers and Students

    NASA Astrophysics Data System (ADS)

    Dry, M. D.; Patterson, G. L.

    2005-12-01

    Lecture Demonstrations on Earthquakes for K-12 Teachers and Students Since 1975, the Center for Earthquake Research and Information, (CERI), at The University of Memphis, has strived to satisfy its information transfer directives through diverse education and outreach efforts, providing technical and non-technical earthquake information to the general public, K-16 teachers and students, professional organizations, and state and federal organizations via all forms of written and electronic communication. <> Through these education and outreach efforts, CERI tries to increase earthquake hazard awareness to help limit future losses. <>In the past three years, education programs have reached over 20,000 K-16 students and teachers through in-service training workshops for teachers and earthquake/earth science lecture demonstrations for students. The presentations include an hour-long lecture demonstration featuring graphics and an informal question and answer format. Graphics used include seismic hazard maps, damage photos, plate tectonic maps, layers of the Earth, and more, all adapted for the audience. Throughout this presentation, manipulatives such as a Slinky, Silly Putty, a foam Earth with depth and temperature features, and Popsicle sticks are used to demonstrate seismic waves, the elasticity of the Earth, the Earth's layers and their features, and the brittleness of the crust. Toward the end, a demonstration featuring a portable shake table with a dollhouse mounted on it is used to illustrate earthquake-shaking effects. This presentation is also taken to schools when they are unable to visit CERI. Following this presentation, groups are then taken to the Public Earthquake Resource Center at CERI, a space featuring nine displays, seven of which are interactive. The interactive displays include a shake table and building blocks, a trench with paleoliquefaction features, computers with web access to seismology sites, a liquefaction model, an oscilloscope and

  14. meoA is the structural gene for outer membrane protein c of Escherichia coli K12.

    PubMed

    van Alphen, L; Lugtenberg, B; van Boxtel, R; Hack, A M; Verhoef, C; Havekes, L

    1979-01-31

    The isolation and characterization of two mutants of Escherichia coli K12 with an altered outer membrane protein c is described. The first mutant, strain CE1151, was isolated as a bacteriophage Me1 resistant strain which contains normal levels of protein c. Mutant cells adsorbed the phage with a strongly decreased rate. Complexes of purified nonheat modified wild type protein c and wild type lipopolysaccharide inactivated phage Me1, indicating that these components are required for receptor activity for phage Me1. When wild type protein c was replaced by protein c of strain CE1151, the receptor-complex was far less active, showing that protein c of strain CE1151 is altered. The second mutant produces a protein c with a decreased electrophoretic mobility, designated as protein c. An altered apparent molecular weight was also observed for one or more fragments obtained after fragmentation of the mutant protein with cyanogen bromide, trypsin and chymotrypsin. Alteration of protein c was not accompanied by a detectable alteration in protein b or its fragments. Both mutations are located at minute 48 of the Escherichia coli K12 linkage map. The results strongly suggest that meoA is the structural gene for protein c.

  15. The Next Generation Science Standards: An Historic Opportunity for K-12 Earth and Space Science Education

    NASA Astrophysics Data System (ADS)

    Johnson, R. M.; Passow, M. J.; Holzer, M. A.; Moore, J.

    2014-12-01

    The Next Generation Science Standards (NGSS) provide an historic opportunity to significantly improve Earth and space science (ESS) education nationally at the K-12 level. The increased emphasis on ESS related topics in the NGSS relative to previous standards provides a real opportunity for ensuring all K-12 students in adopting states learn about the ESS - allowing us to reach many more students than are currently are exposed to our discipline. The new standards are also exciting in that they explicitly couple science and engineering practice, cross-cutting concepts, and disciplinary core ideas in such a way that student must actively demonstrate their understanding through actions rather than through mere regurgitation of memorized responses. Achieving mastery of NGSS Performance Expectations will require practice with higher-order learning skills - with students engaging in the practices of scientists and engineers. Preparing students for this mastery will be a challenging task for teachers, since in many states professional development support is limited at best for the current curriculum - let alone the curricula that will be developed to address the NGSS. As adoption of the NGSS expands across the country, states will be at various levels of implementation of the new standards over the next several years - and there is real concern that teachers must have sufficient professional development to be able to be successful in preparing their students - particularly in view of likely coupled assessments and teacher evaluations. NESTA strongly supports implementation of the NGSS, and the rigorous and compelling ESS education it will engender, when coupled with a strong emphasis nationwide on teacher professional development. For the past two years, the National Earth Science Teachers Association (NESTA) has continued our leadership in K-12 ESS education through workshops, web seminars, events and publications that emphasize implementation of the NGSS in ESS

  16. Abdominal Fat and Sarcopenia in Women Significantly Alter Osteoblasts Homeostasis In Vitro by a WNT/β-Catenin Dependent Mechanism

    PubMed Central

    Wannenes, Francesca; Papa, Vincenza; Greco, Emanuela A.; Fornari, Rachele; Marocco, Chiara; Di Luigi, Luigi; Donini, Lorenzo M.; Lenzi, Andrea

    2014-01-01

    Obesity and sarcopenia have been associated with mineral metabolism derangement and low bone mineral density (BMD). We investigated whether imbalance of serum factors in obese or obese sarcopenic patients could affect bone cell activity in vitro. To evaluate and characterize potential cellular and molecular changes of human osteoblasts, cells were exposed to sera of four groups of patients: (1) affected by obesity with normal BMD (O), (2) affected by obesity with low BMD (OO), (3) affected by obesity and sarcopenia (OS), and (4) affected by obesity, sarcopenia, and low BMD (OOS) as compared to subjects with normal body weight and normal BMD (CTL). Patients were previously investigated and characterized for body composition, biochemical and bone turnover markers. Then, sera of different groups of patients were used to incubate human osteoblasts and evaluate potential alterations in cell homeostasis. Exposure to OO, OS, and OOS sera significantly reduced alkaline phosphatase, osteopontin, and BMP4 expression compared to cells exposed to O and CTL, indicating a detrimental effect on osteoblast differentiation. Interestingly, sera of all groups of patients induced intracellular alteration in Wnt/β-catenin molecular pathway, as demonstrated by the significant alteration of specific target genes expression and by altered β-catenin cellular compartmentalization and GSK3β phosphorylation. In conclusion our results show for the first time that sera of obese subjects with low bone mineral density and sarcopenia significantly alter osteoblasts homeostasis in vitro, indicating potential detrimental effects of trunk fat on bone formation and skeletal homeostasis. PMID:24963291

  17. Abdominal Fat and Sarcopenia in Women Significantly Alter Osteoblasts Homeostasis In Vitro by a WNT/ β -Catenin Dependent Mechanism.

    PubMed

    Wannenes, Francesca; Papa, Vincenza; Greco, Emanuela A; Fornari, Rachele; Marocco, Chiara; Baldari, Carlo; Di Luigi, Luigi; Emerenziani, Gian Pietro; Poggiogalle, Eleonora; Guidetti, Laura; Donini, Lorenzo M; Lenzi, Andrea; Migliaccio, Silvia

    2014-01-01

    Obesity and sarcopenia have been associated with mineral metabolism derangement and low bone mineral density (BMD). We investigated whether imbalance of serum factors in obese or obese sarcopenic patients could affect bone cell activity in vitro. To evaluate and characterize potential cellular and molecular changes of human osteoblasts, cells were exposed to sera of four groups of patients: (1) affected by obesity with normal BMD (O), (2) affected by obesity with low BMD (OO), (3) affected by obesity and sarcopenia (OS), and (4) affected by obesity, sarcopenia, and low BMD (OOS) as compared to subjects with normal body weight and normal BMD (CTL). Patients were previously investigated and characterized for body composition, biochemical and bone turnover markers. Then, sera of different groups of patients were used to incubate human osteoblasts and evaluate potential alterations in cell homeostasis. Exposure to OO, OS, and OOS sera significantly reduced alkaline phosphatase, osteopontin, and BMP4 expression compared to cells exposed to O and CTL, indicating a detrimental effect on osteoblast differentiation. Interestingly, sera of all groups of patients induced intracellular alteration in Wnt/ β -catenin molecular pathway, as demonstrated by the significant alteration of specific target genes expression and by altered β -catenin cellular compartmentalization and GSK3 β phosphorylation. In conclusion our results show for the first time that sera of obese subjects with low bone mineral density and sarcopenia significantly alter osteoblasts homeostasis in vitro, indicating potential detrimental effects of trunk fat on bone formation and skeletal homeostasis. PMID:24963291

  18. The Significance of Acid Alteration in the Los Humeros High-Temperature Geothermal Field, Puebla, Mexico.

    NASA Astrophysics Data System (ADS)

    Elders, W. A.; Izquierdo, G.

    2014-12-01

    The Los Humeros geothermal field is a high-enthalpy hydrothermal system with more than 40 drilled deep wells, mostly producing high steam fractions at > 300oC. However, although it has a large resource potential, low permeability and corrosive acid fluids have hampered development so that it currently has an installed electrical generating capacity of only 40 MWe. The widespread production of low pH fluids from the reservoir is inconsistent with the marked absence in the reservoir rocks of hydrothermal minerals typical of acid alteration. Instead the hydrothermal alteration observed is typical of that due to neutral to alkaline pH waters reacting with the volcanic rocks of the production zones. Thus it appears that since the reservoir has recently suffered a marked drop in fluid pressure and is in process of transitioning from being water-dominated to being vapor-dominated. However sparse examples of acid leaching are observed locally at depths of about 2 km in the form of bleached, intensely silicified zones, in low permeability and very hot (>350oC) parts of reservoir. Although these leached rocks retain their primary volcanic and pyroclastic textures, they are altered almost entirely to microcrystalline quartz, with some relict pseudomorphs of plagioclase phenocrysts and traces of earlier-formed hydrothermal chlorite and pyrite. These acid-altered zones are usually only some tens of meters thick and deeper rocks lack such silicification. The acid fluids responsible for their formation could either be magmatic volatiles, or could be formed during production (e.g. reaction of water and salts forming hydrogen chloride by hydrolysis at high temperatures). The very high boron content of the fluids produced by the Los Humeros wells suggests that their ultimate source is most likely magmatic gases. However, these acid gases did not react widely with the rocks. We suggest that the silicified zones are forming locally where colder descending waters are encountering

  19. Construction of an improved D-arabinose pathway in Escherichia coli K-12.

    PubMed Central

    Bartkus, J M; Mortlock, R P

    1986-01-01

    A ribitol catabolic pathway was transduced into Escherichia coli K-12 in an effort to determine whether the ribitol pathway would confer an advantage to D-arabinose-positive mutants growing on D-arabinose as the sole carbon source. Competition studies in chemostats showed that ribitol-positive strains, with a selection coefficient of 9%/h, have a significant competitive advantage over ribitol-negative strains. Ribitol-positive strains grown in batch culture also exhibited a shorter lag period than did ribitol-negative strains when transferred from glucose to D-arabinose. Repeated transfer of a ribitol-positive strain of E. coli K-12 on D-arabinose yielded a strain with further improved growth on D-arabinose. This "evolved" strain was found to constitutively synthesize L-fucose permease, isomerase, and kinase but had lost the ability to grow on L-fucose, apparently owing to the loss of a functional aldolase. This constitutive mutation is not linked to the fucose gene cluster and may be similar to an unlinked constitutive mutation described by Chen et al. (J. Bacteriol. 159:725-729, 1984). PMID:3512519

  20. Polyphenols from olive mill waste affect biofilm formation and motility in Escherichia coli K-12.

    PubMed

    Carraro, Lisa; Fasolato, Luca; Montemurro, Filomena; Martino, Maria Elena; Balzan, Stefania; Servili, Maurizio; Novelli, Enrico; Cardazzo, Barbara

    2014-05-01

    Olive mill wastes are sources of phenolic compounds with a wide array of biological activities, including antimicrobial effects. A potential option for bioremediation to overcome ecological problems is the reutilization of these natural compounds in food production. The aim of this work was to gain a better understanding of the antimicrobial mode of action of a phenols extract from olive vegetation water (PEOVW) at molecular level by studying Escherichia coli as a model microorganism. Genome-wide transcriptional analysis was performed on E. coli K-12 exposed to PEOVW. The repression of genes for flagellar synthesis and the involvement of genes linked to biofilm formation and stress response were observed. Sub-inhibitory concentrations of PEOVW significantly decreased biofilm formation, swarming and swimming motility, thus confirming the gene expression data. This study provides interesting insights on the molecular action of PEOVW on E. coli K-12. Given these anti-biofilm properties and considering that biofilm formation is a serious problem for the food industry and human health, PEOVW has proved to be a high-value natural product.

  1. Berry Shriveling Significantly Alters Shiraz (Vitis vinifera L.) Grape and Wine Chemical Composition.

    PubMed

    Šuklje, Katja; Zhang, Xinyi; Antalick, Guillaume; Clark, Andrew C; Deloire, Alain; Schmidtke, Leigh M

    2016-02-01

    Berry shriveling is an often reported occurrence in the Shiraz (Vitis vinifera L.) cultivar. This study investigated the effect of berry shriveling occurring in a high yielding (18.6 ± 1.6 kg/vine) Shiraz vineyard in relation to a temporal investigation of grape and wine composition using three harvest dates. Berry shriveling resulted in delayed total soluble solids and amino acid accumulation into the berry, however differences between treatments diminished or became smaller by the third harvest date. Similarly, ethyl esters of fatty acids and higher alcohol acetates were lower in wines from shriveled berries from the first two harvests; anthocyanins were reduced in wines from shriveled berries at all harvest dates, whereas terpenes were unaltered. Wines made from shriveled berries had higher γ-nonalactone and β-damascenone concentrations. This study provides novel information on the chemical alterations of grapes and wines made from grapes affected by shriveling.

  2. K--12 science educator perception of instructing students with learning disabilities in the regular classroom

    NASA Astrophysics Data System (ADS)

    Holliday-Cashwell, Janet Rose

    2000-10-01

    Selected K--12 public school science educators in 14 eastern North Carolina counties were surveyed to examine their perceptions of their undergraduate preparation programs with regard to instructing students with learning disabilities in the regular classroom. A quantitative study, this research examined science educator preparedness in instructing students with learning disabilities by evaluating educator perception in regard to mainstrearned and inclusive educational settings. Specifically, two null hypotheses were tested. Null hypothesis I stated a significant difference does not exist between selected North Carolina K--12 science educators' perceptions of their undergraduate teacher education preparation programs and their perceptions of their abilities to instruct students needing accommodations on behalf of their learning disabilities in mainstrearned or inclusive settings. Participants' responses to perception as well as value statements regarding opinions, adaptations, and undergraduate training with respect to mainstreaming and inclusion were evaluated through t-test analyses of 22 Likert-scale items. Null hypothesis 1 was not accepted because a statistically significant difference did exist between the educators' perceptions of their undergraduate training and their perceived abilities to instruct students with learning disabilities in mainstreamed or inclusive settings. Null hypothesis 2 stated a significant difference does not exist between selected North Carolina K--12 science educators' attained educational level; grade level currently taught, supervised or chaired; and years of experience in teaching science, supervising science education, and/or chairing science departments in selected North Carolina public schools and their opinions of their undergraduate teacher education program with regard to instructing students with learning disabilities in mainstreamed or inclusive educational settings. Null hypothesis 2 was evaluated through an analysis of

  3. Derepression of β-Galactosidase Synthesis in Escherichia coli K-12 by p-Fluorophenylalanine

    PubMed Central

    Kang, Soosang; Rockey, Paul; Markovitz, Alvin

    1968-01-01

    p-Fluorophenylalanine (FPA) derepresses β-galactosidase synthesis at 35 C but not at 25 C in Escherichia coli K-12, strain MC132 (lac I1,2), a strain with a temperature-sensitive lac repressor. In contrast, strain MC130 (lac I+) is not derepressed by FPA at 35 C. Temperature-shift experiments with strain MC132 in the presence of FPA and other reagents (isopropyl-1-thio-β-d-galactoside or chloramphenicol) are consistent with the following mechanism. FPA is incorporated into the genetically altered lac repressor at all temperatures. This further alteration due to incorporation of analogue makes the lac repressor protein inactive at 35 C but active at 25 C. Once an active tertiary structure is formed at 25 C, it is stable at 35 C. However, the inactive tertiary structure of the FPA-containing repressor can assume an active tertiary structure when the temperature is shifted from 35 to 25 C. In the discussion of the results, “inactive tertiary structure” is equated with “monomers” and “active tertiary structure” with oligomers. PMID:4874301

  4. Transforming Public Education: Pathway to a Pre-K-12 Future

    ERIC Educational Resources Information Center

    Pew Center on the States, 2011

    2011-01-01

    In its final report, Pre-K Now laid out a strategy to transform public education by moving from the current K-12 model to a more effective, evidence-based pre-K-12 system, based upon the vital learning that happens in children's earliest years. This pre-K-12 vision is grounded in rigorous research and reflects work by leading scholars and…

  5. Carboxyl group modification significantly altered the kinetic properties of purified carboxymethylcellulase from Aspergillus niger.

    PubMed

    Siddiqui; Saqib; Rashid; Rajoka

    2000-10-01

    Carboxymethylcellulase (CMCase) from Aspergillus niger NIAB280 was purified by a combination of ammonium sulphate precipitation, ion-exchange, hydrophobic interaction and gel filtration chromatography on FPLC with 9-folds increase in specific activity. Native and subunit molecular weights were found to be 36 kDa each. The purified CMCase was modified by 1-ethyl-3(3-dimethylaminopropyl) carbodiimide (EDC) in the presence of glycinamide for 15 min (GAM15) and glycinamide plus cellobiose for 75 min (GAM75). Similarly, the enzyme was modified by EDC in the presence of ethylenediamine dihydrochloride plus cellobiose for 75 min (EDAM75). The neutralization (GAM15 and GAM75) and reversal (EDAM75) of negative charges of carboxyl groups of CMCase had profound effect on the specificity constant (k(cat)/K(m)), pH optima, pK(a)'s of the active-site residues and thermodynamic parameters of activation. The specificity constants of native, GAM15, GAM75, and EDAM75 were 143, 340, 804, and 48, respectively. The enthalpy of activation (DeltaH(#)) of Carboxymethylcellulose (CMC) hydrolysis of native (50 and 15 kJ mol(-1)) and GAM15 (41 and 16 kJ mol(-1)) were biphasic whereas those of GAM75 (43 kJ mol(-1)) and EDAM75 (41 k J mol(-1)) were monophasic. Similarly, the entropy of activation (DeltaS(#)) of CMC hydrolysis of native (-61 and -173 J mol(-1) K(-1)) and GAM15 (-91 and -171 J mol(-1) K(-1)) were biphasic whereas those of GAM75 (-82 J mol(-1) K(-1)) and EDAM75 (-106 J mol(-1) K(-1)) were monophasic. The pH optima/pK(a)'s of both acidic and basic limbs of charge neutralized CMCases increased compared with those of native enzyme. The CMCase modification in the presence of glycinamide and absence of cellobiose at different pH's periodically activated and inhibited the enzyme activity indicating conformational changes. We believe that the alteration of the surface charges resulted in gross movement of loops that surround the catalytic pocket, thereby inducing changes in the vicinity

  6. Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutations.

    PubMed

    Gagliardi, Lucia; Ho, Jui T; Torpy, David J

    2010-03-01

    Corticosteroid-binding globulin (CBG) is the specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic-pituitary-adrenal axis responses and CBG:tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels. These include the Leuven and Lyon mutations which reduce CBG:cortisol binding affinity 3- and 4-fold, respectively, and the null mutation resulting in a 50% (heterozygote) or 100% (homozygote) reduction in CBG levels. The three reported null homozygotes demonstrate that complete CBG deficiency is not lethal, although it may be associated with hypotension and fatigue. The phenotype of a CBG null murine model included fatigue and immune defects. One community-based study revealed that severe CBG mutations are rare in idiopathic fatigue disorders. The mechanisms by which CBG mutations may cause fatigue are unknown. There are preliminary data of altered CBG levels in hypertension and in the metabolic syndrome; however, the nature of these associations is uncertain. Further studies may clarify the functions of CBG, and clinical observations may validate and/or extend the phenotypic features of various CBG mutations.

  7. Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIA non-small cell lung cancer.

    PubMed

    Hirashima, T; Komiya, T; Nitta, T; Takada, Y; Kobayashi, M; Masuda, N; Matui, K; Takada, M; Kikui, M; Yasumitu, T; Ohno, A; Nakagawa, K; Fukuoka, M; Kawase, I

    2000-01-01

    This study was performed to evaluate the prognostic significance of alteration in telomere length in pathological stage (p-stage) I-IIIA non-small cell lung cancer (NSCLC). Paired cancer and normal lung tissues were obtained from 72 patients with histologically confirmed p-stage I-IIIA NSCLC. Terminal restriction fragment (TRF) length, which indicates telomere length, was measured by Southern blot analysis. Tumor telomerase activity was also assayed by non-radioactive PCR-ELISA in 55 patients. TRF length (mean +/- SD) in normal tissue was 6.2 +/- 1.1 Kb. Therefore, upper and lower limits of normal range in TRF length was set at 8.4 (mean + 2SD) Kb and 4.0 (mean-2SD) Kb, respectively. A tumor showing TRF length over normal range was defined as positive for the alteration. In 72 patients, 25 (34.7%) with alteration in TRF length had significantly shorter survival durations than those of the others. Telomerase activity did not correlate with survival duration. In multivariate analysis, alteration in TRF length (P = 0.0033) was second to p-stage (P = 0.0004) in importance among the various parameters.

  8. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

    PubMed

    Shaw, Maureen A; Kombrinck, Keith W; McElhinney, Kathryn E; Sweet, David R; Flick, Matthew J; Palumbo, Joseph S; Cheng, Mei; Esmon, Naomi L; Esmon, Charles T; Brill, Alexander; Wagner, Denisa D; Degen, Jay L; Mullins, Eric S

    2016-08-01

    Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to α-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1) the inactive intermediate, prethrombin; or (2) the proteolytically active intermediate, meizothrombin (fIIa(MZ)). FIIa(MZ) has distinct catalytic properties relative to fIIa, including diminished fibrinogen cleavage and increased protein C activation. Thus, fII activation may differentially influence hemostasis and disease depending on the pathway of activation. To determine the in vivo physiologic and pathologic consequences of restricting thrombin generation to fIIa(MZ), mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(MZ) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(WT) mice, and have reproductive success. Although in vitro studies revealed delayed generation of fIIa(MZ) enzyme activity, platelet aggregation by fII(MZ) is similar to fII(WT) Consistent with prior analyses of human fIIa(MZ), significant prolongation of clotting times was observed for fII(MZ) plasma. Adult fII(MZ) animals displayed significantly compromised hemostasis in tail bleeding assays, but did not demonstrate overt bleeding. More notably, fII(MZ) mice had 2 significant phenotypic advantages over fII(WT) animals: protection from occlusive thrombosis after arterial injury and markedly diminished metastatic potential in a setting of experimental tumor metastasis to the lung. Thus, these novel animals will provide a valuable tool to assess the role of both fIIa and fIIa(MZ) in vivo. PMID:27252233

  9. Education for a New Era: Design and Implementation of K-12 Education Reform in Qatar. Monograph

    ERIC Educational Resources Information Center

    Brewer, Dominic J.; Augustine, Catherine H.; Zellman, Gail L.; Ryan, Gery; Goldman, Charles A.; Stasz, Cathleen; Constant, Louay

    2007-01-01

    The leadership of Qatar has a social and political vision that calls for improving the outcomes of the Qatari K-12 education system. With this vision in mind, the leadership asked RAND to examine Qatar's K-12 education system, to recommend options for building a world-class system, and, subsequently, to develop the chosen option and support its…

  10. Integrating Data Mining in Program Evaluation of K-12 Online Education

    ERIC Educational Resources Information Center

    Hung, Jui-Long; Hsu, Yu-Chang; Rice, Kerry

    2012-01-01

    This study investigated an innovative approach of program evaluation through analyses of student learning logs, demographic data, and end-of-course evaluation surveys in an online K-12 supplemental program. The results support the development of a program evaluation model for decision making on teaching and learning at the K-12 level. A case study…

  11. Review of the National Research Council's Framework for K-12 Science Education

    ERIC Educational Resources Information Center

    Gross, Paul R.

    2011-01-01

    The new "Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas" is a big, comprehensive volume, carefully organized and heavily documented. It is the long-awaited product of the Committee on a Conceptual Framework for New K-12 Science Education Standards. As noted, it is a weighty document (more than 300 crowded…

  12. Education Imperatives for Ohio: K-12 Policy Priorities for the Next Biennium

    ERIC Educational Resources Information Center

    Thomas B. Fordham Foundation, 2010

    2010-01-01

    For the past two decades, lawmakers from both parties in Ohio have invested heavily in the public education sector. As a consequence, total K-12 education funding, measured in constant dollars, has grown by over 60 percent since 1997, even as Ohio's K-12 student enrollment has shrunk by more than 24,000 students (1.4 percent) during that same…

  13. Pairing K-12 Teachers with Geographic Researchers: Why It Should Take Place and How It Can.

    ERIC Educational Resources Information Center

    Orvis, Kenneth H.; Horn, Sally P.; Jumper, Sidney R.

    1999-01-01

    Contends that excitement can be infused into the K-12 geography curriculum by involving teachers in real research projects led by professional geographers. Describes a project where K-12 teachers and geographers participated in geography field research in the mountain highlands of the Valle Nuevo Scientific Reserve of the Dominican Republic. (CMK)

  14. From Teacher to Teacher Educator: Should You Move from a K-12 Classroom into Higher Education?

    ERIC Educational Resources Information Center

    Clement, Mary C.

    2011-01-01

    College teaching can be as rewarding as a K-12 career and, whether in elementary school or college, students deserve good teachers. College professors who prepare teachers can have a tremendous impact on K-12 classrooms for decades into the future. However, career paths vary widely, and the path to teaching in higher education is as unique as the…

  15. Analysis of the Supporting Websites for the Use of Instructional Games in K-12 Settings

    ERIC Educational Resources Information Center

    Kebritchi, Mansureh; Hirumi, Atsusi; Kappers, Wendi; Henry, Renee

    2009-01-01

    This paper identifies resources to be included in a website designed to facilitate the integration of instructional games in K-12 settings. Guidelines and supporting components are based on a survey of K-12 educators who are integrating games, an analysis of existing instructional game websites, and summaries of literature on the use of…

  16. Keeping Pace with K-12 Digital Learning: An Annual Review of Policy and Practice. Eleventh Edition

    ERIC Educational Resources Information Center

    Watson, John; Pape, Larry; Murin, Amy; Gemin, Butch; Vashaw, Lauren

    2014-01-01

    "Keeping Pace with K-12 Digital Learning" (2014) is the 11th in a series of annual reports that began in 2004 that examine the status of K-12 online education across the country. The report provides an overview of the latest policies, practices, and trends affecting online learning programs across all 50 states. It summarizes that at a…

  17. A Critique of the Brave New World of K-12 Education

    ERIC Educational Resources Information Center

    Salmani Nodoushan, Mohammad Ali

    2008-01-01

    Over the past few decades life style has changed so rapidly that remote areas of the Earth are now inhabited by human beings. Technology has also developed and people can stay at home and have access to virtual schools. This has stimulated the need for K-12 Education. K-12 education has emerged from the no-child-left-behind concerns of governments…

  18. Identity and Biography as Mediators of Science and Mathematics Faculty's Involvement in K-12 Service

    ERIC Educational Resources Information Center

    Skerrett, Allison; Sevian, Hannah

    2010-01-01

    This article explores aspects of science and mathematics faculty identities and biographies that mediated their involvement in K-12 service. Faculty expressed five motivations for participating in K-12 service--advancing their research agenda, advocating environmental consciousness, desiring to be involved in their children's schools, aspiring to…

  19. K-12 Online Learning and Students with Disabilities: Perspectives from State Special Education Directors

    ERIC Educational Resources Information Center

    Burdette, Paula J.; Greer, Diana L.; Woods, Kari L.

    2013-01-01

    K-12 special education policies and practices that ensure students with disabilities receive a free, appropriate public education in the least restrictive environment are coming under pressure from the rapid expansion of online learning. Forty-six state and non-state jurisdiction special education directors responded to a brief survey about K-12

  20. Teacher Perception of Barriers and Benefits in K-12 Technology Usage

    ERIC Educational Resources Information Center

    Carver, Lin B.

    2016-01-01

    This study explores K-12 teachers' perceptions of the benefits and barriers to technology integration by either teachers or students in K-12 instruction. The sample was composed of 68 students enrolled in online classes in the graduate studies in education department of a small private liberal arts institution in the southeast. Data was collected…

  1. An Exploratory Study on K-12 Teachers' Use of Technology and Multimedia in the Classroom

    ERIC Educational Resources Information Center

    Martin, Florence; Carr, Marsha L.

    2015-01-01

    21st century has seen new technology and multimedia made available for integration in K-12 classrooms. This exploratory study examines K-12 teachers' use of technology and multimedia in the classroom in two southern counties in the Southeastern United States. The purpose of the study was to answer the following five research questions: 1) What…

  2. Finished Genome Sequence of Escherichia coli K-12 Strain HMS174 (ATCC 47011).

    PubMed

    Mairhofer, Juergen; Krempl, Peter M; Thallinger, Gerhard G; Striedner, Gerald

    2014-11-20

    Escherichia coli strain K-12 substrain HMS174 is an engineered descendant of the E. coli K-12 wild-type strain. Like its ancestor, it is an important organism in biotechnological research and is used in fermentation processes for heterologous protein production. Here, we report the complete genome sequence of E. coli HMS174 (ATCC 47011).

  3. Mapping the Terrain: Educational Leadership Field Experiences in K-12 Virtual Schools

    ERIC Educational Resources Information Center

    LaFrance, Jason A.; Beck, Dennis

    2014-01-01

    Opportunities for K-12 students to choose virtual and blended learning experiences continue to grow. All 50 states including Washington, D.C., now offer some virtual experience in K-12 education. Of these, 40 states have state virtual schools or state-led online learning initiatives. In addition, federal and state support for this type of learning…

  4. Internet Searching by K-12 Students: A Research-Based Process Model

    ERIC Educational Resources Information Center

    Guinee, Kathleen

    2004-01-01

    Understanding K-12 students' Web-based research practices and the challenges posed by this task, can help educators assist students with learning to manage this complex process. In this presentation, I propose a research-based process model of K-12 students' Internet search practices. The model describes the ways in which students search for,…

  5. Development of an Attitude Scale to Assess K-12 Teachers' Attitudes toward Nanotechnology

    ERIC Educational Resources Information Center

    Lan, Yu-Ling

    2012-01-01

    To maximize the contributions of nanotechnology to this society, at least 60 countries have put efforts into this field. In Taiwan, a government-funded K-12 Nanotechnology Programme was established to train K-12 teachers with adequate nanotechnology literacy to foster the next generation of Taiwanese people with sufficient knowledge in…

  6. Will Your Students Be Ready for College? Connecting K-12 and College Standards for Information Literacy.

    ERIC Educational Resources Information Center

    Cahoy, Ellysa Stern

    2002-01-01

    Suggests how to implement information literacy standards at all education levels. Discusses two sets of information literacy standards for K-12 and postsecondary education, K-12/academic library cooperation, comparing Association of College and Research Libraries (ACRL) Information Literacy Competency Standards with American Association of School…

  7. Stacks of Ideas: Activities for Library Media Center and Classroom K-12.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City.

    Developed for library media specialists and teachers, this K-12 guide presents a model for combining library media skills with the regular instructional program. Following a K-12 scope and sequence for library and information skills, 15 elementary and junior high school units and 12 high school units are presented. The elementary and junior high…

  8. K-12 Education and the Internet: A Technical Report Prepared for Saskatchewan Education, Training and Employment.

    ERIC Educational Resources Information Center

    Proctor, L. F.; Allen, A. J.

    This report examines the context and impact on the classroom of teacher and student access to the Internet in K-12 education in Saskatchewan (Canada) public schools. It begins with a description of the Internet, including funding and connectivity concerns. The following four basic services of the Internet are introduced with examples of K-12

  9. K-12 Teachers' Perceptions of School Policy and Fear of School Violence

    ERIC Educational Resources Information Center

    Ricketts, Melissa L.

    2007-01-01

    Since the 1990s, schools have focused their attention on policies designed to improve school safety. Most researches on school violence policies have concentrated on the needs of students and administrators. This study investigated the impact of school violence policies on K-12 teachers' fear. Using self-report data from 447 K-12 teachers from a…

  10. Students with Special Health Care Needs in K-12 Virtual Schools

    ERIC Educational Resources Information Center

    Fernandez, Heidi; Ferdig, Richard E.; Thompson, Lindsay A.; Schottke, Katherine; Black, Erik W.

    2016-01-01

    This study sought to establish a baseline for understanding the epidemiology of online K-12 students with special health care needs, determine the prevalence in K-12 online schooling of students from certain racial/ethnic backgrounds, those with socioeconomic disadvantages, and determine how these students perform in online classes compared to…

  11. The Efficiency and Effectiveness of the K-12 Energy Technology Education Promotion Centers in Taiwan

    ERIC Educational Resources Information Center

    Lee, Lung-Sheng

    2013-01-01

    In order to promote energy literacy for graders K-12, the Ministry of Education (MOE) in Taiwan initiated a K-12 Energy Technology Education Project in September 2010. This 40-month project has one project office affiliated to a university, and 18 promotion centers affiliated to 18 schools--including 5 regional centers for upper-secondary schools…

  12. Efficacy of supercritical carbon dioxide for nonthermal inactivation of Escherichia coli K12 in apple cider

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study evaluated the efficacy of a supercritical carbon dioxide (SCCO2) system with a gas-liquid porous metal contactor for eliminating Escherichia coli K12 in apple cider. Pasteurized, preservative-free apple cider was inoculated with E. coli K12 and processed using the SCCO2 system at CO2 conc...

  13. Development and Evaluation of Food Safety Modules for K-12 Science Education

    ERIC Educational Resources Information Center

    Chapin, Travis K.; Pfuntner, Rachel C.; Stasiewicz, Matthew J.; Wiedmann, Martin; Orta-Ramirez, Alicia

    2015-01-01

    Career and educational opportunities in food science and food safety are underrecognized by K-12 students and educators. Additionally, misperceptions regarding nature of science understanding persist in K-12 students despite being emphasized as an important component of science education for over 100 y. In an effort to increase awareness…

  14. Safety Assessment of the Oral Cavity Probiotic Streptococcus salivarius K12

    PubMed Central

    Burton, Jeremy P.; Wescombe, Philip A.; Moore, Chris J.; Chilcott, Chris N.; Tagg, John R.

    2006-01-01

    Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12. PMID:16598017

  15. Extended Safety Data for the Oral Cavity Probiotic Streptococcus salivarius K12.

    PubMed

    Burton, J P; Chilcott, C N; Wescombe, P A; Tagg, J R

    2010-10-01

    Previous studies of the bacteriocin-producing Streptococcus salivarius K12 monitored a variety of intrinsic strain characteristics of potential relevance to its application as an oral probiotic in humans. These included the content of antibiotic resistance and virulence determinants, the production of deleterious metabolic by-products and its genetic stability. In the present study, we examined additional safety factors including the responses of rats to either short- or long-term oral dosing with strain K12 preparations. In addition, the potential genotoxicity of strain K12 was tested using a bacterial reverse mutation assay. To determine the occurrence and concentrations in human saliva of S. salivarius having the same bacteriocin phenotype as strain K12, saliva samples from 780 children were evaluated. The level of dosing with strain K12 required to achieve oral cavity colonization levels similar to those occurring naturally for this type of bacteriocin-producing S. salivarius was established using 100 human subjects. Following the oral instillation of lyophilized S. salivarius K12 cells in these subjects, its persistence was not at levels higher than those found naturally for this type of bacterium. The various sets of data obtained in this study showed no evidence of genotoxicity and no acute or subacute toxicity effects associated with strain K12. Based on the previously published data, the long history of use by humans and the information presented here, it is concluded that S. salivarius K12 is safe for human consumption. PMID:26781236

  16. Safety assessment of the oral cavity probiotic Streptococcus salivarius K12.

    PubMed

    Burton, Jeremy P; Wescombe, Philip A; Moore, Chris J; Chilcott, Chris N; Tagg, John R

    2006-04-01

    Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12. PMID:16598017

  17. Educating Tomorrow's Workforce: A Report on the Semiconductor Industry's Commitment to Youth in K-12.

    ERIC Educational Resources Information Center

    Semiconductor Industry Association, San Jose, CA.

    The U.S. semiconductor industry, now the nation's largest manufacturing industry, displays its commitment to training its current workers and educating future workers by supporting educational efforts on the K-12 level. This catalog describes innovative actions by 16 Semiconductor Industry Association companies to improve education at the K-12

  18. Trend Analysis of Indiana K-12 Library Services Since the School Library Printed Materials Grant

    ERIC Educational Resources Information Center

    Plucker, Jonathan; Humphrey, Jack; Simmons, Ada; Ravert, Russell; Kohler, Kristin; Hansen, John

    2004-01-01

    The Indiana General Assembly recognized the importance of updating school library book collections by appropriating $4 million for K-8 schools during the 1997-1999 school years, $6 million for K-12 schools during the 1999-2001 school years, and $6 million for K-12 schools for the 2001-2003 school years. However, due to state budgetary restraints,…

  19. Physical Education Teacher Educator's Perceptions toward and Understanding of K-12 Online Physical Education

    ERIC Educational Resources Information Center

    Daum, David N.; Woods, Amelia M.

    2015-01-01

    K-12 online physical education (OLPE) is as an educational opportunity in at least 30 states in the US (NASPE, 2006; 2010; 2012). The purpose of this study was to examine physical education teacher educators' perceptions toward and understanding of K-12 OLPE. Bandura's Social Cognitive Theory (1986) served as the theoretical framework for this…

  20. Problems Associated with a Lack of Cohesive Policy in K-12 Pre-College Engineering

    ERIC Educational Resources Information Center

    Chandler, John; Fontenot, A. Dean; Tate, Derrick

    2011-01-01

    This article identifies a number of issues associated with current STEM education reform efforts, especially with regard to efforts to integrate engineering education into the K-12 curriculum. Precollege engineering is especially problematic in STEM reform since there is no well-established tradition of engineering in the K-12 curriculum. This…

  1. Review of "Overcoming the Governance Challenge in K-12 Online Learning"

    ERIC Educational Resources Information Center

    Barbour, Michael

    2012-01-01

    This fifth and final paper in the Fordham Institute's series examining digital learning policy is "Overcoming the Governance Challenge in K-12 Online Learning". The purpose of this report is to outline the steps required to move the governance of K-12 online learning from the local district level to the less restrictive state level and to create a…

  2. STEM Integration in K-12 Education: Status, Prospects, and an Agenda for Research

    ERIC Educational Resources Information Center

    Honey, Margaret; Pearson, Greg; Schweingruber, Heidi

    2014-01-01

    "STEM Integration in K-12 Education" examines current efforts to connect the STEM disciplines in K-12 education. This report identifies and characterizes existing approaches to integrated STEM education, both in formal and after- and out-of-school settings. The report reviews the evidence for the impact of integrated approaches on…

  3. Opinions on Computing Education in Korean K-12 System: Higher Education Perspective

    ERIC Educational Resources Information Center

    Kim, Dae-Kyoo; Jeong, Dongwon; Lu, Lunjin; Debnath, Debatosh; Ming, Hua

    2015-01-01

    The need for computing education in the K-12 curriculum has grown globally. The Republic of Korea is not an exception. In response to the need, the Korean Ministry of Education has announced an outline for software-centric computing education in the K-12 system, which aims at enhancing the current computing education with software emphasis. In…

  4. Identity and biography as mediators of science and mathematics faculty's involvement in K-12 service

    NASA Astrophysics Data System (ADS)

    Skerrett, Allison; Sevian, Hannah

    2010-09-01

    This article explores aspects of science and mathematics faculty identities and biographies that mediated their involvement in K-12 service. Faculty expressed five motivations for participating in K-12 service—advancing their research agenda, advocating environmental consciousness, desiring to be involved in their children's schools, aspiring to improve their pedagogical practices and promoting equity and social justice.

  5. Virtual Schools: The Changing Landscape of K-12 Education in the U.S.

    ERIC Educational Resources Information Center

    Toppin, Ian N.; Toppin, Sheila M.

    2016-01-01

    Virtual schools are a growing phenomenon in k-12 education. School systems in almost every state in the United States offer some version of fully online or blended education. It is no longer far-fetched to conclude that if the current trend continues, virtual school enrollments will eclipse those of traditional brick-and-mortar k-12 institutions…

  6. New Learning Models: The Evolution of Online Learning into Innovative K-12 Blended Programs

    ERIC Educational Resources Information Center

    Patrick, Susan

    2011-01-01

    The author traces the growth of K-12 online learning in the United States from its modest genesis in the mid-1990s with 50,000 students to the more than 4 million enrollments today, the fastest scaling ever of any innovation in K-12 education. The evolution from one-size-fits-all online courses to innovative, blended instructional models that are…

  7. K-12 Teachers: Technology Use and the Second Level Digital Divide

    ERIC Educational Resources Information Center

    Reinhart, Julie M.; Thomas, Earl; Toriskie, Jeanne M.

    2011-01-01

    This exploratory study examines differences in K-12 educators' use of technology for instruction across school economic factors. Survey data from 94 practicing K-12 teachers are analyzed. This study finds that schools' economic factors explain variation in how teachers use technology to promote higher-order thinking skills. Our findings support…

  8. A Framework for Quality K-12 Engineering Education: Research and Development

    ERIC Educational Resources Information Center

    Moore, Tamara J.; Glancy, Aran W.; Tank, Kristina M.; Kersten, Jennifer A.; Smith, Karl A.; Stohlmann, Micah S.

    2014-01-01

    Recent U.S. national documents have laid the foundation for highlighting the connection between science, technology, engineering and mathematics at the K-12 level. However, there is not a clear definition or a well-established tradition of what constitutes a quality engineering education at the K-12 level. The purpose of the current work has been…

  9. Geckos significantly alter foot orientation to facilitate adhesion during downhill locomotion.

    PubMed

    Birn-Jeffery, Aleksandra V; Higham, Timothy E

    2014-10-01

    Geckos employ their adhesive system when moving up an incline, but the directionality of the system may limit function on downhill surfaces. Here, we use a generalist gecko to test whether limb modulation occurs on downhill slopes to allow geckos to take advantage of their adhesive system. We examined three-dimensional limb kinematics for geckos moving up and down a 45° slope. Remarkably, the hind limbs were rotated posteriorly on declines, resulting in digit III of the pes facing a more posterior direction (opposite to the direction of travel). No significant changes in limb orientation were found in any other condition. This pes rotation leads to a dramatic shift in foot function that facilitates the use of the adhesive system as a brake/stabilizer during downhill locomotion and, although this rotation is not unique to geckos, it is significant for the deployment of adhesion. Adhesion is not just advantageous for uphill locomotion but can be employed to help deal with the effects of gravity during downhill locomotion, highlighting the incredible multi-functionality of this key innovation.

  10. Antipolarity in the ilv Operon of Escherichia coli K-12

    PubMed Central

    Wechsler, James A.; Adelberg, E. A.

    1969-01-01

    The genes governing three of the enzymes of the isoleucine-valine biosynthetic pathway form the operon: operator-ilvA-ilvD-ilvE. The enzymes are: ilvA, l-threonine deaminase; ilvD, dihydroxy acid dehydrase; and ilvE, transaminase B. A nonsense mutation in the ilvD gene (D-ochre) and a nonsense mutation in the ilvE gene (E-amber) affect the properties of the proximal gene product, l-threonine deaminase (TD), in addition to inactivating the enzymes produced by the genes in which the mutations have occurred. The D-ochre mutation causes TD to move in diffusion and gel filtration experiments as though it were 30% smaller than the wild-type enzyme. The E-amber mutation causes TD to move in similar experiments as though it were much larger than the wild-type enzyme. Both mutations completely abolish the sensitivity of TD to l-isoleucine, the normal feedback inhibitor of the wild-type enzyme. The effects of the nonsense mutations on TD can be reversed in three ways: by genetic reversion of the D-ochre mutation; by treatment of the altered enzymes with 3.0 m urea; and by forming a heterozygous diploid, containing the wild-type allele as well as the mutant allele of ilvD or ilvE. The results suggest that the subunits of TD undergo abnormal aggregation in the presence of the partial polypeptides produced by the mutant alleles of ilvD or ilvE; multi-enzyme aggregates in extracts of wild type, however, could not be detected. PMID:4892370

  11. Climate Change Education Today in K-12: What's Happening in the Earth and Space Science Classroom?

    NASA Astrophysics Data System (ADS)

    Holzer, M. A.; National Earth Science Teachers Association

    2011-12-01

    Climate change is a highly interdisciplinary topic, involving not only multiple fields of science, but also social science and the humanities. There are many aspects of climate change science that make it particularly well-suited for exploration in the K-12 setting, including opportunities to explore the unifying processes of science such as complex systems, models, observations, change and evolution. Furthermore, this field of science offers the opportunity to observe the nature of science in action - including how scientists develop and improve their understanding through research and debate. Finally, climate change is inherently highly relevant to students - indeed, students today will need to deal with the consequences of the climate change. The science of climate change is clearly present in current science education standards, both at the National level as well as in the majority of states. Nonetheless, a significant number of teachers across the country report difficulties addressing climate change in the classroom. The National Earth Science Teachers Association has conducted several surveys of Earth and space science educators across the country over the past several years on a number of issues, including their needs and concerns, including their experience of external influences on what they teach. While the number of teachers that report external pressures to not teach climate change science are in the minority (and less than the pressure to not teach evolution and related topics), our results suggest that this pressure against climate change science in the K-12 classroom has grown over the past several years. Some teachers report being threatened by parents, being encouraged by administrators to not teach the subject, and a belief that the "two sides" of climate change should be taught. Survey results indicate that teachers in religious or politically-conservative districts are more likely to report difficulties in teaching about climate change than in

  12. Sorafenib Metabolism Is Significantly Altered in the Liver Tumor Tissue of Hepatocellular Carcinoma Patient

    PubMed Central

    Guo, Enshuang; Chen, Weiying; Lu, Linlin; Wang, Ying; Peng, Xiaojuan; Yan, Tongmeng; Zhou, Fuyan; Liu, Zhongqiu

    2014-01-01

    Background Sorafenib, the drug used as first line treatment for hepatocellular carcinoma (HCC), is metabolized by cytochrome P450 (CYP) 3A4-mediated oxidation and uridine diphosphate glucuronosyl transferase (UGT) 1A9-mediated glucuronidation. Liver diseases are associated with reduced CYP and UGT activities, which can considerably affect drug metabolism, leading to drug toxicity. Thus, understanding the metabolism of therapeutic compounds in patients with liver diseases is necessary. However, the metabolism characteristic of sorafenib has not been systematically determined in HCC patients. Methods Sorafenib metabolism was tested in the pooled and individual tumor hepatic microsomes (THLMs) and adjacent normal hepatic microsomes (NHLMs) of HCC patients (n = 18). Commercial hepatic microsomes (CHLMs) were used as a control. In addition, CYP3A4 and UGT1A9 protein expression in different tissues were measured by Western blotting. Results The mean rates of oxidation and glucuronidation of sorafenib were significantly decreased in the pooled THLMs compared with those in NHLMs and CHLMs. The maximal velocity (Vmax) of sorafenib oxidation and glucuronidation were approximately 25-fold and 2-fold decreased in the pooled THLMs, respectively, with unchanged Km values. The oxidation of sorafenib in individual THLMs sample was significantly decreased (ranging from 7 to 67-fold) than that in corresponding NHLMs sample. The reduction of glucuronidation in THLMs was observed in 15 out of 18 patients’ samples. Additionally, the level of CYP3A4 and UGT1A9 expression were both notably decreased in the pooled THLMs. Conclusions Sorafenib metabolism was remarkably decreased in THLMs. This result was associated with the down regulation of the protein expression of CYP3A4 and UGT1A9. PMID:24797816

  13. Information Infrastructure Technology and Applications (IITA) Program: Annual K-12 Workshop

    NASA Technical Reports Server (NTRS)

    Hunter, Paul; Likens, William; Leon, Mark

    1995-01-01

    The purpose of the K-12 workshop is to stimulate a cross pollination of inter-center activity and introduce the regional centers to curing edge K-1 activities. The format of the workshop consists of project presentations, working groups, and working group reports, all contained in a three day period. The agenda is aggressive and demanding. The K-12 Education Project is a multi-center activity managed by the Information Infrastructure Technology and Applications (IITA)/K-12 Project Office at the NASA Ames Research Center (ARC). this workshop is conducted in support of executing the K-12 Education element of the IITA Project The IITA/K-12 Project funds activities that use the National Information Infrastructure (NII) (e.g., the Internet) to foster reform and restructuring in mathematics, science, computing, engineering, and technical education.

  14. Development of the Advanced Energy Design Guide for K-12 Schools -- 50% Energy Savings

    SciTech Connect

    Bonnema, E.; Leach, M.; Pless, S.; Torcellini, P.

    2013-02-01

    This Technical Support Document (TSD) describes the process and methodology for the development of the Advanced Energy Design Guide for K-12 School Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-K12) (ASHRAE et al. 2011a). The AEDG-K12 provides recommendations for achieving 50% whole-building energy savings in K-12 schools over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-K12 was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy (DOE).

  15. The Biomechanical Implications of Obesity in K-12 Learners

    ERIC Educational Resources Information Center

    Strohmeyer, Scott

    2007-01-01

    Few biomechanical studies have examined obese individuals as primary subjects. However, some mechanical differences have been identified between overweight or obese individuals and nonoverweight movers. It is not clear how obesity affects the onset of osteoarthritis, for example, but it is evident that obesity does place significant limitations on…

  16. Strength in Numbers: State Spending on K-12 Assessment Systems

    ERIC Educational Resources Information Center

    Chingos, Matthew M.

    2012-01-01

    In the coming years, states will need to make the most significant changes to their assessment systems in a decade as they implement the Common Core State Standards, a common framework for what students are expected to know that will replace existing standards in 45 states and the District of Columbia. The Common Core effort has prompted concerns…

  17. Aligning K-12 and Postsecondary Career Pathways with Workforce Needs

    ERIC Educational Resources Information Center

    Zinth, Jennifer

    2015-01-01

    Since 2013, states have witnessed significant legislative activity related to secondary- and postsecondary-level career/technical education (CTE). One key goal of much recent policymaking activity has been to improve alignment between high school and postsecondary CTE programs, including by developing state or regional structures to design career…

  18. The significance of the alteration of 8-OHdG in serous ovarian carcinoma

    PubMed Central

    2013-01-01

    Background Oxidative damage and DNA repair dysfunction are associated with carcinogenesis. 8-OHdG is one of the major oxidative DNA adducts. Present work aims to investigate whether the expression of 8-OHdG and its key repair gene hOGG1 play distinctive role in two types of serous ovarian cancer. Materials and methods 8-OHdG level in DNA from tumor and matched tumor-adjacent normal tissue in 48 high-grade papillary serous carcinomas (HG-SOC), 24 low-grade papillary serous carcinomas (LG-SOC), 20 serous cystadenomas, and 16 non-tumor control ovaries was tested. The Cox proportional hazards model and the log-rank test were used to assess the associations between the 8-OHdG level in two types of serous cancer and patients’ survival. Real-time polymerase chain reaction and protein immunoblot were employed to detect hOGG1 mRNA and protein levels in tumor and adjacent normal tissues. Immunohistochemistry was used to determine the expression of hOGG1 and p53. Results There was no difference of average 8-OHdG/106dG DNA level either between HG-SOC (27.8 ± 8.9), LG-SOC (25.2 ± 7.4) and benign serous cystadenoma (26.5 ± 7.7, p = 0.35); or between the tumor-adjacent normal tissue of HG-SOC (18.8 ± 5.2), LG-SOC (21.4 ± 6.5), benign serous cystadenoma (20.5 ± 9.1) and non-tumor ovary (21.6 ± 4.9, p = 0.62). The 8-OHdG/106dG level was significantly higher in tumor comparing to that in matched normal tissue adjacent to carcinoma in HG-SOC (1.52 ± 0.52, p = 0.02), but not in LG-SOC or benign serous cystadenoma. Increased level of 8-OHdG in tumor DNA was an independent factor of overall survival in serous ovarian carcinoma upon multivariate analysis (p < 0.01). Increased level of 8-OHdG in tumor DNA indicates poorer overall and progression-free survival durations than counterparts (47.3 vs 105.7 months and 13.5 vs 45.3 months, respectively). Protein levels of hOGG1 were remarkably decreased in HG-SOC (p < 0.01), but not in LG

  19. Long-term soil transplant simulating climate change with latitude significantly alters microbial temporal turnover.

    PubMed

    Liang, Yuting; Jiang, Yuji; Wang, Feng; Wen, Chongqing; Deng, Ye; Xue, Kai; Qin, Yujia; Yang, Yunfeng; Wu, Liyou; Zhou, Jizhong; Sun, Bo

    2015-12-01

    To understand soil microbial community stability and temporal turnover in response to climate change, a long-term soil transplant experiment was conducted in three agricultural experiment stations over large transects from a warm temperate zone (Fengqiu station in central China) to a subtropical zone (Yingtan station in southern China) and a cold temperate zone (Hailun station in northern China). Annual soil samples were collected from these three stations from 2005 to 2011, and microbial communities were analyzed by sequencing microbial 16S ribosomal RNA gene amplicons using Illumina MiSeq technology. Our results revealed a distinctly differential pattern of microbial communities in both northward and southward transplantations, along with an increase in microbial richness with climate cooling and a corresponding decrease with climate warming. The microbial succession rate was estimated by the slope (w value) of linear regression of a log-transformed microbial community similarity with time (time-decay relationship). Compared with the low turnover rate of microbial communities in situ (w=0.046, P<0.001), the succession rate at the community level was significantly higher in the northward transplant (w=0.058, P<0.001) and highest in the southward transplant (w=0.094, P<0.001). Climate warming lead to a faster succession rate of microbial communities as well as lower species richness and compositional changes compared with in situ and climate cooling, which may be related to the high metabolic rates and intense competition under higher temperature. This study provides new insights into the impacts of climate change on the fundamental temporal scaling of soil microbial communities and microbial phylogenetic biodiversity.

  20. Recent trends in vegetation greenness in China significantly altered annual evapotranspiration and water yield

    NASA Astrophysics Data System (ADS)

    Liu, Yibo; Xiao, Jingfeng; Ju, Weimin; Xu, Ke; Zhou, Yanlian; Zhao, Yuntai

    2016-09-01

    There has been growing evidence that vegetation greenness has been increasing in many parts of the northern middle and high latitudes including China during the last three to four decades. However, the effects of increasing vegetation greenness particularly afforestation on the hydrological cycle have been controversial. We used a process-based ecosystem model and a satellite-derived leaf area index (LAI) dataset to examine how the changes in vegetation greenness affected annual evapotranspiration (ET) and water yield for China over the period from 2000 to 2014. Significant trends in vegetation greenness were observed in 26.1% of China’s land area. We used two model simulations driven with original and detrended LAI, respectively, to assess the effects of vegetation ‘greening’ and ‘browning’ on terrestrial ET and water yield. On a per-pixel basis, vegetation greening increased annual ET and decreased water yield, while vegetation browning reduced ET and increased water yield. At the large river basin and national scales, the greening trends also had positive effects on annual ET and had negative effects on water yield. Our results showed that the effects of the changes in vegetation greenness on the hydrological cycle varied with spatial scale. Afforestation efforts perhaps should focus on southern China with larger water supply given the water crisis in northern China and the negative effects of vegetation greening on water yield. Future studies on the effects of the greenness changes on the hydrological cycle are needed to account for the feedbacks to the climate.

  1. Dietary Mannoheptulose Does Not Significantly Alter Daily Energy Expenditure in Adult Labrador Retrievers.

    PubMed

    McKnight, Leslie L; Root-McCaig, Jared; Wright, David; Davenport, Gary M; France, James; Shoveller, Anna Kate

    2015-01-01

    Mannoheptulose (MH), a sugar found in avocados that inhibits glycolysis in vitro, has been preliminarily investigated as a novel food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocado, on energy expenditure (EE) in healthy adult Labrador Retriever dogs (total of 12 dogs, 26.99 ± 0.634 kg, 4.9 ± 0.2 y). The study was a double-blind, cross-over with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet; 6 mg/kg BW), in random order. Resting and post-prandial (10 h) EE and respiratory quotient (RQ) were determined by indirect calorimetry (d 42). The following day, body composition was assessed using dual X-ray absorptiometry. Continuous activity monitoring was conducted using an Atical® accelerometer (d 43-47). A vastus lateralis muscle biopsy was obtained prior to the morning meal (d 49) and 4 h after consumption of their meal (d 56) to determine the protein content and phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Diet did not affect body weight, resting EE or skeletal muscle AMPK phosphorylation. Dogs fed MH had significantly lower post-prandial RQ (p = 0.02) and ratio of fat to lean body mass (p = 0.02). Physical activity during light time periods (but not dark) was lower in dogs fed MH (p < 0.05) during weekends, but not on weekdays. These results suggest that MH affects energy balance of adult dogs, but that these effects are not dose dependent and not due to physical activity. PMID:26656105

  2. Dietary Mannoheptulose Does Not Significantly Alter Daily Energy Expenditure in Adult Labrador Retrievers.

    PubMed

    McKnight, Leslie L; Root-McCaig, Jared; Wright, David; Davenport, Gary M; France, James; Shoveller, Anna Kate

    2015-01-01

    Mannoheptulose (MH), a sugar found in avocados that inhibits glycolysis in vitro, has been preliminarily investigated as a novel food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocado, on energy expenditure (EE) in healthy adult Labrador Retriever dogs (total of 12 dogs, 26.99 ± 0.634 kg, 4.9 ± 0.2 y). The study was a double-blind, cross-over with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet; 6 mg/kg BW), in random order. Resting and post-prandial (10 h) EE and respiratory quotient (RQ) were determined by indirect calorimetry (d 42). The following day, body composition was assessed using dual X-ray absorptiometry. Continuous activity monitoring was conducted using an Atical® accelerometer (d 43-47). A vastus lateralis muscle biopsy was obtained prior to the morning meal (d 49) and 4 h after consumption of their meal (d 56) to determine the protein content and phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Diet did not affect body weight, resting EE or skeletal muscle AMPK phosphorylation. Dogs fed MH had significantly lower post-prandial RQ (p = 0.02) and ratio of fat to lean body mass (p = 0.02). Physical activity during light time periods (but not dark) was lower in dogs fed MH (p < 0.05) during weekends, but not on weekdays. These results suggest that MH affects energy balance of adult dogs, but that these effects are not dose dependent and not due to physical activity.

  3. Dietary Mannoheptulose Does Not Significantly Alter Daily Energy Expenditure in Adult Labrador Retrievers

    PubMed Central

    McKnight, Leslie L.; Root-McCaig, Jared; Wright, David; Davenport, Gary M.; France, James; Shoveller, Anna Kate

    2015-01-01

    Mannoheptulose (MH), a sugar found in avocados that inhibits glycolysis in vitro, has been preliminarily investigated as a novel food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocado, on energy expenditure (EE) in healthy adult Labrador Retriever dogs (total of 12 dogs, 26.99 ± 0.634 kg, 4.9 ± 0.2 y). The study was a double-blind, cross-over with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet; 6 mg/kg BW), in random order. Resting and post-prandial (10 h) EE and respiratory quotient (RQ) were determined by indirect calorimetry (d 42). The following day, body composition was assessed using dual X-ray absorptiometry. Continuous activity monitoring was conducted using an Atical® accelerometer (d 43–47). A vastus lateralis muscle biopsy was obtained prior to the morning meal (d 49) and 4 h after consumption of their meal (d 56) to determine the protein content and phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Diet did not affect body weight, resting EE or skeletal muscle AMPK phosphorylation. Dogs fed MH had significantly lower post-prandial RQ (p = 0.02) and ratio of fat to lean body mass (p = 0.02). Physical activity during light time periods (but not dark) was lower in dogs fed MH (p < 0.05) during weekends, but not on weekdays. These results suggest that MH affects energy balance of adult dogs, but that these effects are not dose dependent and not due to physical activity. PMID:26656105

  4. Expression of R-plasmid functions during anaerobic growth of an Escherichia coli K-12 host.

    PubMed Central

    Burman, L G

    1977-01-01

    The normal habitat of enteric bacteria is largely anaerobic. Expression of the three characteristic properties of R-plasmids, drug resistance, vegetative replication, and fertility, was therefore studied in Escherichia coli K-12 during anaerobiosis. Replication and drug resistance functions were not altered in the 45 R-plasmids studies, whereas the expression of fertility varied considerably among different R-plasmids during anaerobiosis. The R-plasmids could be divided into three groups, one showing a strong, the second a moderate, and the third little or no reduction of fertility by anaerobiosis. Plasmid-determined sensitivity to F-, N-, and I-specific phage, respectively, was well, although not absolutely, correlated with each of three groups mentioned. Anaerobiosis-aerobiosis appears to change the fertility of type F R-plasmids by influencing the degree of repression of their fertility functions such as the formation of sex pili. Although the minimum inhibitory concentrations of ampicillin, chloramphenicol, streptomycin, and tetracycline were unaltered by anaerobiosis, sulfonamide was found to be four- to eightfold less active under this condition in both resistant and sensitive strains. A surprisingly high frequency and uniformity of minimal inhibitory concentrations was observed for R-plasmid-mediated resistance to streptomycin and chloramphenicol. PMID:326771

  5. Recommendations for Broader Impacts in K-12: Advice from Einstein Educator Fellows

    NASA Astrophysics Data System (ADS)

    Pacheco, H. A.; LaDue, N.; Moore, J. D.; Whitsett, S.

    2011-12-01

    Since 1994, the Albert Einstein Distinguished Science Educator Fellowship Act has brought Master K-12 STEM educators to Washington D.C. and Virginia for 11-month appointments in STEM-related Federal agencies and Congressional Offices. These top educators are leaders in their communities and often have years of experience working with government-funded researchers reaching out to the K-12 community. During their fellowship year, Einstein Fellows use their years of experience and expertise in to inform efforts and initiatives in the federal departments, directorates and offices to which they are assigned. The collaborative efforts of a group of NSF Einstein Fellows has led to the development of "Broader Impacts in the K-12 Community", a suite of experience-based recommendations and ideas designed to leverage grant resources and maximize effective partnerships between the research and K-12 communities. The goal of this presentation is to communicate best practices for researchers engaging in the realm of K-12 education from the perspective of educators. Challenges are highlighted and mapped to realistic solutions. Written originally as a panel talk to help NSF panel members consider feasible, high-quality K-12 broader impacts, this presentation has become an invaluable resource for principle investigators as they consider engaging with the K-12 community. While this presentation specifically addresses merit review components of NSF solicitations, these recommendations are relevant for any STEM initiatives that involve partnerships between scientists and teachers.

  6. Characterization of the cyn operon in Escherichia coli K12.

    PubMed

    Sung, Y C; Fuchs, J A

    1988-10-15

    Escherichia coli can overcome the toxicity of environmental cyanate by hydrolysis of cyanate to ammonia and bicarbonate. This reaction is catalyzed by the enzyme cyanase, encoded by the cynS gene. The nucleotide sequence of cynS has been reported (Sung, Y.-c., Anderson, P. M., and Fuchs, J. A. (1987) J. Bacteriol. 169, 5224-5230). The nucleotide sequence of the complete cyn operon has now been determined. The cyn operon is approximately 2600 base pairs and includes cynT, cynS, and cynX, which encode cyanate permease, cyanase, and a protein of unknown function, respectively. Two cyanate-inducible transcripts of 1500 and 2500 nucleotides, respectively, were detected by Northern blot analysis. S1 nuclease mapping experiments indicated that two different cyn mRNAs have a common 5'-end and two different 3'-ends. One 3'-end was located within the coding region of cynX, whereas the other 3'-end includes the entire DNA sequence of cynX. The longer transcript contained 98 nucleotides complementary to lac mRNA produced by the predominant lac transcription termination sequence. Termination vectors were used to show that both 3'-ends were generated by sequences that caused transcriptional termination in vivo. Expression vectors were used to demonstrate that a protein corresponding to the expected size was synthesized from the DNA fragment containing the open reading frame designated cynX. The predicted amino acid sequence of cynX indicates that it is a very hydrophobic protein. The level of cynX expression was significantly less than that of cynT or cynS expression.

  7. In Search of the Active Site of PMMO Enzyme: Partnership between a K-12 Teacher, a Graduate K-12 Teaching Fellow, and a Research Mentor

    ERIC Educational Resources Information Center

    Bearden, Katherine K.; Mainardi, Daniela S.; Culligan, Tanya

    2009-01-01

    The partnership between a K-12 teacher (Culligan), an NSF GK-12 Teaching Fellow graduate student (Bearden), and a Louisiana Tech faculty member (Mainardi) collaborating in a research and education project is described in this work. The unique grouping of these three researchers allows for maximum dissemination of developed modules. By the end of…

  8. Stock culture heterogeneity rather than new mutational variation complicates short-term cell physiology studies of Escherichia coli K-12 MG1655 in continuous culture.

    PubMed

    Nahku, Ranno; Peebo, Karl; Valgepea, Kaspar; Barrick, Jeffrey E; Adamberg, Kaarel; Vilu, Raivo

    2011-09-01

    Nutrient-limited continuous cultures in chemostats have been used to study microbial cell physiology for over 60 years. Genome instability and genetic heterogeneity are possible uncontrolled factors in continuous cultivation experiments. We investigated these issues by using high-throughput (HT) DNA sequencing to characterize samples from different phases of a glucose-limited accelerostat (A-stat) experiment with Escherichia coli K-12 MG1655 and a duration regularly used in cell physiology studies (20 generations of continuous cultivation). Seven consensus mutations from the reference sequence and five subpopulations characterized by different mutations were detected in the HT-sequenced samples. This genetic heterogeneity was confirmed to result from the stock culture by Sanger sequencing. All the subpopulations in which allele frequencies increased (betA, cspG/cspH, glyA) during the experiment were also present at the end of replicate A-stats, indicating that no new subpopulations emerged during our experiments. The fact that ~31 % of the cells in our initial cultures obtained directly from a culture stock centre were mutants raises concerns that even if cultivations are started from single colonies, there is a significant chance of picking a mutant clone with an altered phenotype. Our results show that current HT DNA sequencing technology allows accurate subpopulation analysis and demonstrates that a glucose-limited E. coli K-12 MG1655 A-stat experiment with a duration of tens of generations is suitable for studying cell physiology and collecting quantitative data for metabolic modelling without interference from new mutations.

  9. A comparative analysis of industrial Escherichia coli K-12 and B strains in high-glucose batch cultivations on process-, transcriptome- and proteome level.

    PubMed

    Marisch, Karoline; Bayer, Karl; Scharl, Theresa; Mairhofer, Juergen; Krempl, Peter M; Hummel, Karin; Razzazi-Fazeli, Ebrahim; Striedner, Gerald

    2013-01-01

    Escherichia coli K-12 and B strains are among the most frequently used bacterial hosts for production of recombinant proteins on an industrial scale. To improve existing processes and to accelerate bioprocess development, we performed a detailed host analysis. We investigated the different behaviors of the E. coli production strains BL21, RV308, and HMS174 in response to high-glucose concentrations. Tightly controlled cultivations were conducted under defined environmental conditions for the in-depth analysis of physiological behavior. In addition to acquisition of standard process parameters, we also used DNA microarray analysis and differential gel electrophoresis (Ettan(TM) DIGE). Batch cultivations showed different yields of the distinct strains for cell dry mass and growth rate, which were highest for BL21. In addition, production of acetate, triggered by excess glucose supply, was much higher for the K-12 strains compared to the B strain. Analysis of transcriptome data showed significant alteration in 347 of 3882 genes common among all three hosts. These differentially expressed genes included, for example, those involved in transport, iron acquisition, and motility. The investigation of proteome patterns additionally revealed a high number of differentially expressed proteins among the investigated hosts. The subsequently selected 38 spots included proteins involved in transport and motility. The results of this comprehensive analysis delivered a full genomic picture of the three investigated strains. Differentially expressed groups for targeted host modification were identified like glucose transport or iron acquisition, enabling potential optimization of strains to improve yield and process quality. Dissimilar growth profiles of the strains confirm different genotypes. Furthermore, distinct transcriptome patterns support differential regulation at the genome level. The identified proteins showed high agreement with the transcriptome data and suggest

  10. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

    SciTech Connect

    Hamrick, Mark W.; Herberg, Samuel; Arounleut, Phonepasong; He, Hong-Zhi; Shiver, Austin; Qi, Rui-Qun; Zhou, Li; Isales, Carlos M.; and others

    2010-09-24

    Research highlights: {yields} Aging is associated with muscle atrophy and loss of muscle mass, known as the sarcopenia of aging. {yields} We demonstrate that age-related muscle atrophy is associated with marked changes in miRNA expression in muscle. {yields} Treating aged mice with the adipokine leptin significantly increased muscle mass and the expression of miRNAs involved in muscle repair. {yields} Recombinant leptin therapy may therefore be a novel approach for treating age-related muscle atrophy. -- Abstract: Age-associated loss of muscle mass, or sarcopenia, contributes directly to frailty and an increased risk of falls and fractures among the elderly. Aged mice and elderly adults both show decreased muscle mass as well as relatively low levels of the fat-derived hormone leptin. Here we demonstrate that loss of muscle mass and myofiber size with aging in mice is associated with significant changes in the expression of specific miRNAs. Aging altered the expression of 57 miRNAs in mouse skeletal muscle, and many of these miRNAs are now reported to be associated specifically with age-related muscle atrophy. These include miR-221, previously identified in studies of myogenesis and muscle development as playing a role in the proliferation and terminal differentiation of myogenic precursors. We also treated aged mice with recombinant leptin, to determine whether leptin therapy could improve muscle mass and alter the miRNA expression profile of aging skeletal muscle. Leptin treatment significantly increased hindlimb muscle mass and extensor digitorum longus fiber size in aged mice. Furthermore, the expression of 37 miRNAs was altered in muscles of leptin-treated mice. In particular, leptin treatment increased the expression of miR-31 and miR-223, miRNAs known to be elevated during muscle regeneration and repair. These findings suggest that aging in skeletal muscle is associated with marked changes in the expression of specific miRNAs, and that nutrient

  11. Does degree of alteration in effort sense caused by eccentric exercise significantly affect initial exercise hyperpnea in humans?

    PubMed

    Hotta, Norio; Yamamoto, Kaoru; Ogata, Hisayoshi; Maher, Patrick; Okumura, Naoya; Ishida, Koji

    2016-01-01

    Previous research has shown an exaggeration in exercise hyperpnea 2 days after eccentric exercise (ECC). Enhancement in central command has been suggested as one candidate to account for this effect given that ECC-induced neuromuscular dysfunction increases relative exercise intensity, thus resulting in reinforcement of effort sense. The purpose of this study was, therefore, to elucidate whether the degree of alteration in effort sense caused by ECC affects exercise hyperpnea. Ten subjects performed 20-s single-arm extension-flexion exercises with weight strapped to the wrist, and ventilatory response was measured before (Pre) and 2 days after ECC (D2). Relative exercise intensity at Pre was 5 % of maximal voluntary contraction (MVC) of Pre, whereas that at D2 was 9 % MVC of D2 because of decline in muscle strength. Ventilatory responses were significantly exaggerated at D2 with a significant increase in effort sense. Although effort sense was significantly reduced during exercise at D2 when wrist weight was subtracted to match relative exercise intensity at Pre (5 % MVC of D2), ventilatory responses were still significantly higher than those of Pre. After the disappearance of post-ECC muscle damage, subjects performed the same exercise with weight added (9 % MVC of Pre) so that effort was equalized to match that of D2; however, no significant increase in ventilatory response was detected. The fact that the extent of change in effort sense caused by ECC-induced neuromuscular dysfunction did not affect ventilatory response at the onset of exercise after ECC may suggest that the exaggeration of ventilatory response after ECC is caused by mechanisms other than alteration of the central command. PMID:27558395

  12. The Role of Extension Specialists in Meeting K-12 Science Education Goals.

    ERIC Educational Resources Information Center

    Milam, Michael R.

    1996-01-01

    Describes a variety of ways in which extension specialists can support and supplement the K-12 science curriculum in Missouri. Includes a description of the Missouri Mastery Achievement Test (MMAT) and its use in assessing agricultural literacy. (DDR)

  13. Promoting K-12 Community Research and Service through the Washington Earth Science Initiative.

    ERIC Educational Resources Information Center

    Field, John; DeBari, Susan; Gallagher, Michael

    2003-01-01

    Describes a K-12 teacher enhancement program in Washington state that provides teachers with the background knowledge, human and material resources, and time to develop community-based studies on environmental issues facing the citizens of Washington. (Author/KHR)

  14. Genome-Wide Screening of Genes Required for Swarming Motility in Escherichia coli K-12▿ †

    PubMed Central

    Inoue, Tetsuyoshi; Shingaki, Ryuji; Hirose, Shotaro; Waki, Kaori; Mori, Hirotada; Fukui, Kazuhiro

    2007-01-01

    Escherichia coli K-12 has the ability to migrate on semisolid media by means of swarming motility. A systematic and comprehensive collection of gene-disrupted E. coli K-12 mutants (the Keio collection) was used to identify the genes involved in the swarming motility of this bacterium. Of the 3,985 nonessential gene mutants, 294 were found to exhibit a strongly repressed-swarming phenotype. Further, 216 of the 294 mutants displayed no significant defects in swimming motility; therefore, the 216 genes were considered to be specifically associated with the swarming phenotype. The swarming-associated genes were classified into various functional categories, indicating that swarming is a specialized form of motility that requires a wide variety of cellular activities. These genes include genes for tricarboxylic acid cycle and glucose metabolism, iron acquisition, chaperones and protein-folding catalysts, signal transduction, and biosynthesis of cell surface components, such as lipopolysaccharide, the enterobacterial common antigen, and type 1 fimbriae. Lipopolysaccharide and the enterobacterial common antigen may be important surface-acting components that contribute to the reduction of surface tension, thereby facilitating the swarm migration in the E. coli K-12 strain. PMID:17122336

  15. Cryomilling-induced solid dispersion of poor glass forming/poorly water-soluble mefenamic acid with polyvinylpyrrolidone K12.

    PubMed

    Kang, Naewon; Lee, Jangmi; Choi, Ji Na; Mao, Chen; Lee, Eun Hee

    2015-06-01

    The effect of mechanical impact on the polymorphic transformation of mefenamic acid (MFA) and the formation of a solid dispersion of mefenamic acid, a poor glass forming/poorly-water soluble compound, with polyvinylpyrrolidone (PVP) K12 was investigated. The implication of solid dispersion formation on solubility enhancement of MFA, prepared by cryomilling, was investigated. Solid state characterization was conducted using powder X-ray diffraction (PXRD) and Fourier-transform infrared (FTIR) spectroscopy combined with crystal structure analysis. Apparent solubility of the mixtures in pH 7.4 buffer was measured. A calculation to compare the powder patterns and FTIR spectra of solid dispersions with the corresponding physical mixtures was conducted. Solid state characterization showed that (1) MFA I transformed to MFA II when pure MFA I was cryogenically milled (CM); and (2) MFA forms a solid dispersion when MFA was cryogenically milled with PVP K12. FTIR spectral analysis showed that hydrogen bonding facilitated by mechanical impact played a major role in forming solid dispersions. The apparent solubility of MFA was significantly improved by making a solid dispersion with PVP K12 via cryomilling. This study highlights the importance of cryomilling with a good hydrogen bond forming excipient as a technique to prepare solid dispersion, especially when a compound shows a poor glass forming ability and therefore, is not easy to form amorphous forms by conventional method.

  16. Points of View: Effective Partnerships between K-12 and Higher Education--Moving from Outreach to Partnership: Striving for Articulation and Reform across the K-20+ Science Education Continuum

    ERIC Educational Resources Information Center

    Dolan, Erin; Tanner, Kimberly

    2005-01-01

    One would be hard-pressed to find a college or university in the United States without at least one outreach program designed to support science education in local K-12 schools. Over the last three decades, scores of thriving science education outreach programs have had significant and extraordinarily positive effects on K-12 science education. In…

  17. Development of an Attitude Scale to Assess K-12 Teachers' Attitudes toward Nanotechnology

    NASA Astrophysics Data System (ADS)

    Lan, Yu-Ling

    2012-05-01

    To maximize the contributions of nanotechnology to this society, at least 60 countries have put efforts into this field. In Taiwan, a government-funded K-12 Nanotechnology Programme was established to train K-12 teachers with adequate nanotechnology literacy to foster the next generation of Taiwanese people with sufficient knowledge in nanotechnology. In the present study, the Nanotechnology Attitude Scale for K-12 teachers (NAS-T) was developed to assess K-12 teachers' attitudes toward nanotechnology. The NAS-T included 23 Likert-scale items that can be grouped into three components: importance of nanotechnology, affective tendencies in science teaching, and behavioural tendencies to teach nanotechnology. A sample of 233 K-12 teachers who have participated in the K-12 Nanotechnology Programme was included in the present study to investigate the psychometric properties of the NAS-T. The exploratory factor analysis of this teacher sample suggested that the NAS-T was a three-factor model that explained 64.11% of the total variances. This model was also confirmed by the confirmatory factor analysis to validate the factor structure of the NAS-T. The Cronbach's alpha values of three NAS-T subscales ranged from 0.89 to 0.95. Moderate to strong correlations among teachers' NAS-T domain scores, self-perception of own nanoscience knowledge, and their science-teaching efficacy demonstrated good convergent validity of the NAS-T. As a whole, psychometric properties of the NAS-T indicated that this instrument is an effective instrument for assessing K-12 teachers' attitudes toward nanotechnology. The NAS-T will serve as a valuable tool to evaluate teachers' attitude changes after participating in the K-12 Nanotechnology Programme.

  18. Research Findings on K-12 and 1-12 Rural School Districts in the United States.

    ERIC Educational Resources Information Center

    Barker, Bruce O.; Muse, Ivan D.

    A 1982-83 study conducted at Brigham Young University compared K-12 rural schools with fewer than 300 students to those with enrollments of 301-900, using information from districts in 45 states. Of the 15,601 American K-12/1-12 public school systems, 1,414 (9.1%) were identified as enrolling 300 students or fewer, and 2,711 (17.4%) enrolled…

  19. Plasmid encoded antibiotics inhibit protozoan predation of Escherichia coli K12.

    PubMed

    Ahmetagic, Adnan; Philip, Daniel S; Sarovich, Derek S; Kluver, Daniel W; Pemberton, John M

    2011-09-01

    Bacterial plasmids and phages encode the synthesis of toxic molecules that inhibit protozoan predation. One such toxic molecule is violacein, a purple pigmented, anti-tumour antibiotic produced by the Gram-negative soil bacterium Chromobacterium violaceum. In the current experiments a range of Escherichia coli K12 strains were genetically engineered to produce violacein and a number of its coloured, biosynthetic intermediates. A bactivorous predatory protozoan isolate, Colpoda sp.A4, was isolated from soil and tested for its ability to 'graze' on various violacein producing strains of E. coli K12. A grazing assay was developed based on protozoan "plaque" formation. Using this assay, E. coli K12 strains producing violacein were highly resistant to protozoan predation. However E. coli K12 strains producing violacein intermediates, showed low or no resistance to predation. In separate experiments, when either erythromycin or pentachlorophenol were added to the plaque assay medium, protozoan predation of E. coli K12 was markedly reduced. The inhibitory effects of these two molecules were removed if E. coli K12 strains were genetically engineered to inactivate the toxic molecules. In the case of erythromycin, the E. coli K12 assay strain was engineered to produce an erythromycin inactivating esterase, PlpA. For pentachlorophenol, the E. coli K12 assay strain was engineered to produce a PCP inactivating enzyme pentachlorophenol-4-monooxygenase (PcpB). This study indicates that in environments containing large numbers of protozoa, bacteria which use efflux pumps to remove toxins unchanged from the cell may have an evolutionary advantage over bacteria which enzymatically inactivate toxins.

  20. Genome sequence of the lantibiotic bacteriocin producer Streptococcus salivarius strain K12.

    PubMed

    Barretto, Caroline; Alvarez-Martin, Pablo; Foata, Francis; Renault, Pierre; Berger, Bernard

    2012-11-01

    Streptococcus salivarius is a prevalent commensal species of the oropharyngeal tract. S. salivarius strain K12 is an isolate from the saliva of a healthy child, used as an oral probiotic. Here, we report its genome sequence, i.e., the full sequence of the 190-kb megaplasmid pSsal-K12 and a high-quality draft 2.2-Gb chromosomal sequence. PMID:23045482

  1. Genome Sequence of the Lantibiotic Bacteriocin Producer Streptococcus salivarius Strain K12

    PubMed Central

    Alvarez-Martin, Pablo; Foata, Francis; Renault, Pierre

    2012-01-01

    Streptococcus salivarius is a prevalent commensal species of the oropharyngeal tract. S. salivarius strain K12 is an isolate from the saliva of a healthy child, used as an oral probiotic. Here, we report its genome sequence, i.e., the full sequence of the 190-kb megaplasmid pSsal-K12 and a high-quality draft 2.2-Gb chromosomal sequence. PMID:23045482

  2. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

    PubMed

    Cosseau, Celine; Devine, Deirdre A; Dullaghan, Edie; Gardy, Jennifer L; Chikatamarla, Avinash; Gellatly, Shaan; Yu, Lorraine L; Pistolic, Jelena; Falsafi, Reza; Tagg, John; Hancock, Robert E W

    2008-09-01

    Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia, and strain K12 has reported probiotic effects. An emerging paradigm indicates that commensal bacteria downregulate immune responses through the action on NF-kappaB signaling pathways, but additional mechanisms underlying probiotic actions are not well understood. Our objective here was to identify host genes specifically targeted by K12 by comparing their responses with responses elicited by pathogens and to determine if S. salivarius modulates epithelial cell immune responses. RNA was extracted from human bronchial epithelial cells (16HBE14O- cells) cocultured with K12 or bacterial pathogens. cDNA was hybridized to a human 21K oligonucleotide-based array. Data were analyzed using ArrayPipe, InnateDB, PANTHER, and oPOSSUM. Interleukin 8 (IL-8) and growth-regulated oncogene alpha (Groalpha) secretion were determined by enzyme-linked immunosorbent assay. It was demonstrated that S. salivarius K12 specifically altered the expression of 565 host genes, particularly those involved in multiple innate defense pathways, general epithelial cell function and homeostasis, cytoskeletal remodeling, cell development and migration, and signaling pathways. It inhibited baseline IL-8 secretion and IL-8 responses to LL-37, Pseudomonas aeruginosa, and flagellin in epithelial cells and attenuated Groalpha secretion in response to flagellin. Immunosuppression was coincident with the inhibition of activation of the NF-kappaB pathway. Thus, the commensal and probiotic behaviors of S. salivarius K12 are proposed to be due to the organism (i) eliciting no proinflammatory response, (ii) stimulating an anti-inflammatory response, and (iii) modulating genes associated with adhesion to the epithelial layer and homeostasis. S. salivarius K12 might thereby ensure that it is tolerated by the host and maintained on the epithelial surface while actively protecting the host from inflammation and apoptosis

  3. The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis▿ †

    PubMed Central

    Cosseau, Celine; Devine, Deirdre A.; Dullaghan, Edie; Gardy, Jennifer L.; Chikatamarla, Avinash; Gellatly, Shaan; Yu, Lorraine L.; Pistolic, Jelena; Falsafi, Reza; Tagg, John; Hancock, Robert E. W.

    2008-01-01

    Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia, and strain K12 has reported probiotic effects. An emerging paradigm indicates that commensal bacteria downregulate immune responses through the action on NF-κB signaling pathways, but additional mechanisms underlying probiotic actions are not well understood. Our objective here was to identify host genes specifically targeted by K12 by comparing their responses with responses elicited by pathogens and to determine if S. salivarius modulates epithelial cell immune responses. RNA was extracted from human bronchial epithelial cells (16HBE14O- cells) cocultured with K12 or bacterial pathogens. cDNA was hybridized to a human 21K oligonucleotide-based array. Data were analyzed using ArrayPipe, InnateDB, PANTHER, and oPOSSUM. Interleukin 8 (IL-8) and growth-regulated oncogene alpha (Groα) secretion were determined by enzyme-linked immunosorbent assay. It was demonstrated that S. salivarius K12 specifically altered the expression of 565 host genes, particularly those involved in multiple innate defense pathways, general epithelial cell function and homeostasis, cytoskeletal remodeling, cell development and migration, and signaling pathways. It inhibited baseline IL-8 secretion and IL-8 responses to LL-37, Pseudomonas aeruginosa, and flagellin in epithelial cells and attenuated Groα secretion in response to flagellin. Immunosuppression was coincident with the inhibition of activation of the NF-κB pathway. Thus, the commensal and probiotic behaviors of S. salivarius K12 are proposed to be due to the organism (i) eliciting no proinflammatory response, (ii) stimulating an anti-inflammatory response, and (iii) modulating genes associated with adhesion to the epithelial layer and homeostasis. S. salivarius K12 might thereby ensure that it is tolerated by the host and maintained on the epithelial surface while actively protecting the host from inflammation and apoptosis induced by

  4. ETUDE AU MICROSCOPE ELECTRONIQUE DES TRANSFORMATIONS NUCLEAIRES DE E. COLI K12 S ET K12 S (λ26) APRES IRRADIATION AUX RAYONS ULTRAVIOLETS ET AUX RAYONS X

    PubMed Central

    Ryter, Antoinette

    1960-01-01

    Nuclear transformations induced in E. coli K12S and K12S(λ26) by ultraviolet radiations and x-rays have been studied with ultrathin sections in the electron microscope. The nucleoplasm keeps its normal aspect during "fragmentation" and during "condensation" of the nucleus into the "vesicular" form. Serial sections show that the "fragmented" nucleus consists in reality of only one very tortuous vacuole. No difference either in the shape or in the fine structure of the nucleus could be observed between the lysogenic strain and the non-lysogenic strain. A high concentration of NaCl has a "condensation" effect on the fragmented nuclei and decreases the induction rate. PMID:13745076

  5. Efficacy of the World Wide Web in K-12 environmental education

    NASA Astrophysics Data System (ADS)

    York, Kimberly Jane

    1998-11-01

    Despite support by teachers, students, and the American public in general, environmental education is not a priority in U.S. schools. Teachers face many barriers to integrating environmental education into K--12 curricula. The focus of this research is teachers' lack of access to environmental education resources. New educational reforms combined with emerging mass communication technologies such as the Internet and World Wide Web present new opportunities for the infusion of environmental content into the curriculum. New technologies can connect teachers and students to a wealth of resources previously unavailable to them. However, significant barriers to using technologies exist that must be overcome to make this promise a reality. Web-based environmental education is a new field and research is urgently needed. If teachers are to use the Web meaningfully in their classrooms, it is essential that their attitudes and perceptions about using this new technology be brought to light. Therefore, this exploratory research investigates teachers' attitudes toward using the Web to share environmental education resources. Both qualitative and quantitative methods were used to investigate this problem. Two surveys were conducted---self-administered mail survey and a Web-based online survey---to elicit teachers perceptions and comments about environmental education and the Web. Preliminary statistical procedures including frequencies, percentages and correlational measures were performed to interpret the data. In-depth interviews and participant-observation methods were used during an extended environmental education curriculum development project with two practicing teachers to gain insights into the process of creating curricula and placing it online. Findings from the both the mail survey and the Web-based survey suggest that teachers are interested in environmental education---97% of respondents for each survey agreed that environmental education should be taught in K

  6. Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis.

    PubMed

    Browning, Douglas F; Wells, Timothy J; França, Fernanda L S; Morris, Faye C; Sevastsyanovich, Yanina R; Bryant, Jack A; Johnson, Matthew D; Lund, Peter A; Cunningham, Adam F; Hobman, Jon L; May, Robin C; Webber, Mark A; Henderson, Ian R

    2013-03-01

    Escherichia coli has been the leading model organism for many decades. It is a fundamental player in modern biology, facilitating the molecular biology revolution of the last century. The acceptance of E. coli as model organism is predicated primarily on the study of one E. coli lineage; E. coli K-12. However, the antecedents of today's laboratory strains have undergone extensive mutagenesis to create genetically tractable offspring but which resulted in loss of several genetic traits such as O antigen expression. Here we have repaired the wbbL locus, restoring the ability of E. coli K-12 strain MG1655 to express the O antigen. We demonstrate that O antigen production results in drastic alterations of many phenotypes and the density of the O antigen is critical for the observed phenotypes. Importantly, O antigen production enables laboratory strains of E. coli to enter the gut of the Caenorhabditis elegans worm and to kill C. elegans at rates similar to pathogenic bacterial species. We demonstrate C. elegans killing is a feature of other commensal E. coli. We show killing is associated with bacterial resistance to mechanical shear and persistence in the C. elegans gut. These results suggest C. elegans is not an effective model of human-pathogenic E. coli infectious disease.

  7. The UC Berkeley K-12 Science Coalition - Facilitating Student Participation in Space Science Education and Outreach

    NASA Astrophysics Data System (ADS)

    Hawkins, I.

    1999-05-01

    Although many astronomy undergraduate and graduate majors are interested in becoming professional astronomers, there is a growing number of students interested in following their astronomy training with alternate careers in science education. My talk will describe innovative opportunities for students at UC Berkeley to gain experience in K-12 science education and outreach through a coordinated effort, the UC Berkeley K-12 Science Coalition. At institutions of higher education, the many science departments and research units have disciplinary foci that are too specialized to meet the broad needs of the K-12 science curriculum. Thus, coordination of individual efforts is the only way to provide a cohesive program of support for K-12 schools, and fulfill science education standards and curricular requirements at the various grade levels. At UC Berkeley alone, scores of science education and outreach programs exist in many disciplinary areas working with schools at all grade levels. Until recently, these programs have traditionally worked independently of each other and without consistent levels of coordination with school district priorities. The UC Berkeley K-12 Science Coalition has recently been established under the leadership of the campus' Executive Vice Chancellor and Provost, to coordinate individual science outreach efforts to best serve the K-12 community. The goals of such coordination are to improve K-12 student achievement, teacher professional development, and curriculum through a cohesive structure in which the various programs and academic departments/units can contribute effectively. The Science Coalition will also serve as a framework for UC Berkeley students to participate effectively in science education, obtain needed training and experience, as well as an opportunity to explore alternate careers with an astronomy degree.

  8. Brain Based Learning: K-12 Teachers' Preferred Methods of Science Instruction

    NASA Astrophysics Data System (ADS)

    Mansy, Donna Lachman

    The purpose of this quantitative study was to investigate Brain Based Learning (BBL) techniques in teaching science. Participants included 216 K-12, full-time, regular education teachers from 8 Northeast Tennessee school systems who taught at least 1 science class. Specifically this research was guided by 7 research questions on teachers' perceptions and practices in teaching science. Data were collected by a survey that consisted of 82 statements where teachers rated their level of agreement and was distributed online via Survey Monkey. The first portion of my survey included demographic identifiers, teachers' knowledge of the term BBL, and inquiries regarding science background and training. The remainder of the statements were focused on teachers' perceptions and practices of BBL strategies in teaching science. The final item was open-ended and allowed teachers to share comments related to teaching science. For statements 6-81, participants responded by using a 5-point Likert scale that ranged from 1 (strongly disagree) to 5 ( strongly agree). Quantitative data were analyzed with a series of independent samples t tests, one-way analysis of variance tests, and a Pearson correlation coefficient. The results of the study indicate that teachers' perceptions are positively correlated to their self-reported practices. Females, in general, and elementary teachers tend to practice BBL strategies in teaching science significantly more than other subgroups.

  9. Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase

    PubMed Central

    Kim, Hyun Ju; Jeong, Haeyoung; Hwang, Seungwoo; Lee, Moo-Seung; Lee, Yong-Jik; Lee, Dong-Woo; Lee, Sang Jun

    2014-01-01

    Microbial adaptations often occur via genomic mutations under adverse environmental conditions. This study used Escherichia coli ΔadhE cells as a model system to investigate adaptation to anaerobic conditions, which we then compared with the adaptive mechanisms of two closely related E. coli strains, K-12 and B. In contrast to K-12 ΔadhE cells, the E. coli B ΔadhE cells exhibited significantly delayed adaptive growth under anaerobic conditions. Adaptation by the K-12 and B strains mainly employed anaerobic lactate fermentation to restore cellular growth. Several mutations were identified in the pta or pflB genes of adapted K-12 cells, but mostly in the pta gene of the B strains. However, the types of mutation in the adapted K-12 and B strains were similar. Cellular viability was affected directly by severe redox imbalance in B ΔadhE cells, which also impaired their ability to adapt to anaerobic conditions. This study demonstrates that closely related microorganisms may undergo different adaptations under the same set of adverse conditions, which might be associated with the specific metabolic characteristics of each strain. This study provides new insights into short-term microbial adaptation to stressful conditions, which may reflect dynamic microbial population changes in nature. PMID:25250024

  10. Short-term differential adaptation to anaerobic stress via genomic mutations by Escherichia coli strains K-12 and B lacking alcohol dehydrogenase.

    PubMed

    Kim, Hyun Ju; Jeong, Haeyoung; Hwang, Seungwoo; Lee, Moo-Seung; Lee, Yong-Jik; Lee, Dong-Woo; Lee, Sang Jun

    2014-01-01

    Microbial adaptations often occur via genomic mutations under adverse environmental conditions. This study used Escherichia coli ΔadhE cells as a model system to investigate adaptation to anaerobic conditions, which we then compared with the adaptive mechanisms of two closely related E. coli strains, K-12 and B. In contrast to K-12 ΔadhE cells, the E. coli B ΔadhE cells exhibited significantly delayed adaptive growth under anaerobic conditions. Adaptation by the K-12 and B strains mainly employed anaerobic lactate fermentation to restore cellular growth. Several mutations were identified in the pta or pflB genes of adapted K-12 cells, but mostly in the pta gene of the B strains. However, the types of mutation in the adapted K-12 and B strains were similar. Cellular viability was affected directly by severe redox imbalance in B ΔadhE cells, which also impaired their ability to adapt to anaerobic conditions. This study demonstrates that closely related microorganisms may undergo different adaptations under the same set of adverse conditions, which might be associated with the specific metabolic characteristics of each strain. This study provides new insights into short-term microbial adaptation to stressful conditions, which may reflect dynamic microbial population changes in nature.

  11. Effects of sound exposure on the growth and intracellular macromolecular synthesis of E. coli k-12

    PubMed Central

    Zhang, Yongzhu; Wu, Ying

    2016-01-01

    Microbes, as one of the primary producers of the biosphere, play an important role in ecosystems. Exploring the mechanism of adaptation and resistance of microbial population to various environmental factors has come into focus in the fields of modern microbial ecology and molecular ecology. However, facing the increasingly serious problem of acoustic pollution, very few efforts have been put forth into studying the relation of single cell organisms and sound field exposure. Herein, we studied the biological effects of sound exposure on the growth of E. coli K-12 with different acoustic parameters. The effects of sound exposure on the intracellular macromolecular synthesis and cellular morphology of E. coli K-12 were also analyzed and discussed. Experimental results indicated that E. coli K-12 exposed to sound waves owned a higher biomass and a faster specific growth rate compared to the control group. Also, the average length of E. coli K-12 cells increased more than 27.26%. The maximum biomass and maximum specific growth rate of the stimulation group by 8000 Hz, 80dB sound wave was about 1.7 times and 2.5 times that of the control group, respectively. Moreover, it was observed that E. coli K-12 can respond rapidly to sound stress at both the transcriptional and posttranscriptional levels by promoting the synthesis of intracellular RNA and total protein. Some potential mechanisms may be involved in the responses of bacterial cells to sound stress. PMID:27077011

  12. Effects of sound exposure on the growth and intracellular macromolecular synthesis of E. coli k-12.

    PubMed

    Gu, Shaobin; Zhang, Yongzhu; Wu, Ying

    2016-01-01

    Microbes, as one of the primary producers of the biosphere, play an important role in ecosystems. Exploring the mechanism of adaptation and resistance of microbial population to various environmental factors has come into focus in the fields of modern microbial ecology and molecular ecology. However, facing the increasingly serious problem of acoustic pollution, very few efforts have been put forth into studying the relation of single cell organisms and sound field exposure. Herein, we studied the biological effects of sound exposure on the growth of E. coli K-12 with different acoustic parameters. The effects of sound exposure on the intracellular macromolecular synthesis and cellular morphology of E. coli K-12 were also analyzed and discussed. Experimental results indicated that E. coli K-12 exposed to sound waves owned a higher biomass and a faster specific growth rate compared to the control group. Also, the average length of E. coli K-12 cells increased more than 27.26%. The maximum biomass and maximum specific growth rate of the stimulation group by 8000 Hz, 80dB sound wave was about 1.7 times and 2.5 times that of the control group, respectively. Moreover, it was observed that E. coli K-12 can respond rapidly to sound stress at both the transcriptional and posttranscriptional levels by promoting the synthesis of intracellular RNA and total protein. Some potential mechanisms may be involved in the responses of bacterial cells to sound stress.

  13. Effects of sound exposure on the growth and intracellular macromolecular synthesis of E. coli k-12.

    PubMed

    Gu, Shaobin; Zhang, Yongzhu; Wu, Ying

    2016-01-01

    Microbes, as one of the primary producers of the biosphere, play an important role in ecosystems. Exploring the mechanism of adaptation and resistance of microbial population to various environmental factors has come into focus in the fields of modern microbial ecology and molecular ecology. However, facing the increasingly serious problem of acoustic pollution, very few efforts have been put forth into studying the relation of single cell organisms and sound field exposure. Herein, we studied the biological effects of sound exposure on the growth of E. coli K-12 with different acoustic parameters. The effects of sound exposure on the intracellular macromolecular synthesis and cellular morphology of E. coli K-12 were also analyzed and discussed. Experimental results indicated that E. coli K-12 exposed to sound waves owned a higher biomass and a faster specific growth rate compared to the control group. Also, the average length of E. coli K-12 cells increased more than 27.26%. The maximum biomass and maximum specific growth rate of the stimulation group by 8000 Hz, 80dB sound wave was about 1.7 times and 2.5 times that of the control group, respectively. Moreover, it was observed that E. coli K-12 can respond rapidly to sound stress at both the transcriptional and posttranscriptional levels by promoting the synthesis of intracellular RNA and total protein. Some potential mechanisms may be involved in the responses of bacterial cells to sound stress. PMID:27077011

  14. A Longitudinal Study of the Effectiveness of a K-12 Engagement Program on Graduate Student Learning Outcomes

    ERIC Educational Resources Information Center

    Weeks, Faith; Gong, Ruiyang; Harbor, Jon

    2015-01-01

    Programs that connect higher and K-12 education provide benefits to K-12 students, teachers, and higher education. The National Science Foundation (NSF) invested in programs connecting domestic STEM graduate students with K-12 education for over a decade (GK-12), intending that such engagement would help achieve graduate student learning outcomes…

  15. Offering Preservice Teachers Field Experiences in K-12 Online Learning: A National Survey of Teacher Education Programs

    ERIC Educational Resources Information Center

    Kennedy, Kathryn; Archambault, Leanna

    2012-01-01

    Enrollment in K-12 online learning is growing at an exponential rate throughout the United States. Currently, all 50 states offer K-12 online learning opportunities. Some states such as Michigan, Alabama, New Mexico, and Idaho have passed legislative measures requiring K-12 students to complete at least one online learning experience by the time…

  16. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K-12 Community.

    PubMed

    Westenberg, David J

    2016-03-01

    Exposing K-12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS), "engaging in practices that scientists and engineers actually use." This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM) can play a critical role. ASM encourages its members to engage with the K-12 community by providing networking opportunities and resources for ASM members and K-12 teachers to work together to bring microbiology into the classroom. Journal of Microbiology & Biology Education.

  17. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K-12 Community.

    PubMed

    Westenberg, David J

    2016-03-01

    Exposing K-12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS), "engaging in practices that scientists and engineers actually use." This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM) can play a critical role. ASM encourages its members to engage with the K-12 community by providing networking opportunities and resources for ASM members and K-12 teachers to work together to bring microbiology into the classroom. Journal of Microbiology & Biology Education. PMID:27047585

  18. Reduction of group A beta-hemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study

    PubMed Central

    Gregori, Giuseppe; Righi, Ornella; Risso, Paolo; Boiardi, Goffreda; Demuru, Giovanni; Ferzetti, Anna; Galli, Antonio; Ghisoni, Marco; Lenzini, Sonia; Marenghi, Claudio; Mura, Caterina; Sacchetti, Roberto; Suzzani, Lucia

    2016-01-01

    Recurrent pharyngo-tonsillar infections caused by group A beta-hemolytic streptococci (GABHS) occur frequently in young children, and the treatment of these infections contributes substantially to the total current requirement for antibiotic prescribing. Our study goal was to assess through a retrospective observational analysis whether the administration of the oral probiotic, Streptococcus salivarius K12 (SsK12), could reduce the occurrence of GABHS pharyngo-tonsillar infections in children who had a recent history of recurrent episodes of these infections. Twelve primary care pediatricians identified, through their databases, a total of 130 children who had experienced recurrent GABHS pharyngo-tonsillar infections over a period of at least 6–12 months prior to their inclusion in the study. Of these children, 76 then undertook a 90-day program requiring once-a-day dosing with a commercially available (Bactoblis) lozenge containing SsK12. No probiotic supplement was given to the remaining 54 (control) children. Each subject was monitored for the occurrence of GABHS pharyngo-tonsillitis and also for acute otitis media, bronchitis, sinusitis, and bronchopneumonia for at least 12 months following their entry to the study. Even 9 months after the use of SsK12 had been stopped, the probability of new GABHS infections was significantly lower (P>0.001) when compared to the period before dosing commenced. When compared to the untreated children, those taking SsK12 appear to have had significantly fewer GABHS infections both during the 90-day period of prophylaxis and during the following 9 months (P<0.001). These observations are supportive of the use of probiotic SsK12 for the control of recurrent GABHS pharyngo-tonsillar infections in children, and as an associated benefit, the use of this probiotic could lead to reduced antibiotic consumption. Follow-up controlled prospective studies should now be initiated in order to further establish the efficacy of this newly

  19. Reduction of group A beta-hemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study.

    PubMed

    Gregori, Giuseppe; Righi, Ornella; Risso, Paolo; Boiardi, Goffreda; Demuru, Giovanni; Ferzetti, Anna; Galli, Antonio; Ghisoni, Marco; Lenzini, Sonia; Marenghi, Claudio; Mura, Caterina; Sacchetti, Roberto; Suzzani, Lucia

    2016-01-01

    Recurrent pharyngo-tonsillar infections caused by group A beta-hemolytic streptococci (GABHS) occur frequently in young children, and the treatment of these infections contributes substantially to the total current requirement for antibiotic prescribing. Our study goal was to assess through a retrospective observational analysis whether the administration of the oral probiotic, Streptococcus salivarius K12 (SsK12), could reduce the occurrence of GABHS pharyngo-tonsillar infections in children who had a recent history of recurrent episodes of these infections. Twelve primary care pediatricians identified, through their databases, a total of 130 children who had experienced recurrent GABHS pharyngo-tonsillar infections over a period of at least 6-12 months prior to their inclusion in the study. Of these children, 76 then undertook a 90-day program requiring once-a-day dosing with a commercially available (Bactoblis) lozenge containing SsK12. No probiotic supplement was given to the remaining 54 (control) children. Each subject was monitored for the occurrence of GABHS pharyngo-tonsillitis and also for acute otitis media, bronchitis, sinusitis, and bronchopneumonia for at least 12 months following their entry to the study. Even 9 months after the use of SsK12 had been stopped, the probability of new GABHS infections was significantly lower (P>0.001) when compared to the period before dosing commenced. When compared to the untreated children, those taking SsK12 appear to have had significantly fewer GABHS infections both during the 90-day period of prophylaxis and during the following 9 months (P<0.001). These observations are supportive of the use of probiotic SsK12 for the control of recurrent GABHS pharyngo-tonsillar infections in children, and as an associated benefit, the use of this probiotic could lead to reduced antibiotic consumption. Follow-up controlled prospective studies should now be initiated in order to further establish the efficacy of this newly

  20. Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains.

    PubMed

    Han, Mee-Jung; Lee, Sang Yup; Hong, Soon Ho

    2012-04-01

    Recent genome comparisons of E. coli B and K-12 strains have indicated that the makeup of the cell envelopes in these two strains is quite different. Therefore, we analyzed and compared the envelope proteomes of E. coli BL21(DE3) and MG1655. A total of 165 protein spots, including 62 nonredundant proteins, were unambiguously identified by two-dimensional gel electrophoresis and mass spectrometry. Of these, 43 proteins were conserved between the two strains, whereas 4 and 16 strain-specific proteins were identified only in E. coli BL21(DE3) and MG1655, respectively. Additionally, 24 proteins showed more than 2-fold differences in intensities between the B and K-12 strains. The reference envelope proteome maps showed that E. coli envelope mainly contained channel proteins and lipoproteins. Interesting proteomic observations between the two strains were as follows: (i) B produced more OmpF porin with a larger pore size than K-12, indicating an increase in the membrane permeability; (ii) B produced higher amounts of lipoproteins, which facilitates the assembly of outer membrane beta-barrel proteins; and (iii) motility- (FliC) and chemotaxis-related proteins (CheA and CheW) were detected only in K-12, which showed that E. coli B is restricted with regard to migration under unfavorable conditions. These differences may influence the permeability and integrity of the cell envelope, showing that E. coli B may be more susceptible than K-12 to certain stress conditions. Thus, these findings suggest that E. coli K-12 and its derivatives will be more favorable strains in certain biotechnological applications, such as cell surface display or membrane engineering studies.

  1. K-12 Teacher Understanding of Energy Conservation: Conceptual Metaphor, Dissipation, and Degradation

    NASA Astrophysics Data System (ADS)

    Daane, Abigail R.

    In K-12 educational settings, conservation of energy is typically presented in two ways: the conservation of energy principle (energy is neither created nor destroyed) and the sociopolitical need to conserve energy (we guard against energy being used up). These two meanings of conservation typically remain disconnected from each other and can appear contradictory, even after instruction. In an effort to support teachers in building robust understandings of energy from their existing knowledge, I designed a study to investigate the productive ideas in K-12 teachers' conversations about energy. A micro-analysis of discourse, gestures, and artifacts of professional development courses revealed teachers' productive ideas about three aspects of energy: conceptual metaphor, dissipation and degradation. In learning about energy, K-12 teachers come to use conceptual metaphors in their own language and value attending to students' metaphorical language as a means of formative assessment. Teachers' conversations about dissipation suggest that apparent difficulties with energy conservation may have their roots in a strong association between forms of energy (thermal) and their perceptible indicators (warmth). Teachers address this challenge by employing an exaggeration strategy to locate the dissipated thermal energy, making the energy indicator perceptible. Finally, teachers' unprompted statements about sociopolitical aspects of energy are related to both statements from the NGSS and aspects of energy degradation. I conclude that energy conservation can be better taught and learned in K-12 Education by: 1) understanding and applying conceptual metaphors about energy in K-12 settings, 2) using prior experiences to better understand dissipative energy processes involving imperceptible thermal energy, thereby understanding how energy conservation applies in all situations, and 3) connecting productive ideas about sociopolitical aspects of energy to canonical physics. Keywords

  2. Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains.

    PubMed

    Han, Mee-Jung; Lee, Sang Yup; Hong, Soon Ho

    2012-04-01

    Recent genome comparisons of E. coli B and K-12 strains have indicated that the makeup of the cell envelopes in these two strains is quite different. Therefore, we analyzed and compared the envelope proteomes of E. coli BL21(DE3) and MG1655. A total of 165 protein spots, including 62 nonredundant proteins, were unambiguously identified by two-dimensional gel electrophoresis and mass spectrometry. Of these, 43 proteins were conserved between the two strains, whereas 4 and 16 strain-specific proteins were identified only in E. coli BL21(DE3) and MG1655, respectively. Additionally, 24 proteins showed more than 2-fold differences in intensities between the B and K-12 strains. The reference envelope proteome maps showed that E. coli envelope mainly contained channel proteins and lipoproteins. Interesting proteomic observations between the two strains were as follows: (i) B produced more OmpF porin with a larger pore size than K-12, indicating an increase in the membrane permeability; (ii) B produced higher amounts of lipoproteins, which facilitates the assembly of outer membrane beta-barrel proteins; and (iii) motility- (FliC) and chemotaxis-related proteins (CheA and CheW) were detected only in K-12, which showed that E. coli B is restricted with regard to migration under unfavorable conditions. These differences may influence the permeability and integrity of the cell envelope, showing that E. coli B may be more susceptible than K-12 to certain stress conditions. Thus, these findings suggest that E. coli K-12 and its derivatives will be more favorable strains in certain biotechnological applications, such as cell surface display or membrane engineering studies. PMID:22534293

  3. K-12 Math and Science Education: Tales from the Santa Fe Alliance for Science

    NASA Astrophysics Data System (ADS)

    Eisenstein, Robert

    2008-10-01

    Can professional engineers, mathematicians, and scientists have a positive impact on K-12 math and science education? The experience of the Santa Fe Alliance for Science, and several other like-minded organizations, indicates that they can indeed. But success is by no means assured. Good scientists are not automatically good educators, but they can learn enough about pedagogy, classroom, and community to do well. This discussion will be oriented around three major points: lessons learned, prospects for the future, and how our effort fits into state-wide plans for re-inventing K-12 math and science education in New Mexico.

  4. Identification of essential genes and synthetic lethal gene combinations in Escherichia coli K-12.

    PubMed

    Mori, Hirotada; Baba, Tomoya; Yokoyama, Katsushi; Takeuchi, Rikiya; Nomura, Wataru; Makishi, Kazuichi; Otsuka, Yuta; Dose, Hitomi; Wanner, Barry L

    2015-01-01

    Here we describe the systematic identification of single genes and gene pairs, whose knockout causes lethality in Escherichia coli K-12. During construction of precise single-gene knockout library of E. coli K-12, we identified 328 essential gene candidates for growth in complex (LB) medium. Upon establishment of the Keio single-gene deletion library, we undertook the development of the ASKA single-gene deletion library carrying a different antibiotic resistance. In addition, we developed tools for identification of synthetic lethal gene combinations by systematic construction of double-gene knockout mutants. We introduce these methods herein.

  5. Advanced Energy Retrofit Guide: Practical Ways to Improve Energy Performance, K-12 Schools (Book)

    SciTech Connect

    Not Available

    2013-02-01

    The U.S. Department of Energy developed the K-12 Advanced Energy Retrofit Guide to provide specific methodologies, information, and guidance to help energy managers and other stakeholders plan and execute energy efficiency improvements. We emphasize actionable information, practical methodologies, diverse case studies, and unbiased evaluation of the most promising retrofit measure for each building type. K-12 schools were selected as one of the highest priority building sectors, because schools affect the lives of most Americans. They also represent approximately 8% of the energy use and 10% of the floor area in commercial buildings.

  6. Identification of essential genes and synthetic lethal gene combinations in Escherichia coli K-12.

    PubMed

    Mori, Hirotada; Baba, Tomoya; Yokoyama, Katsushi; Takeuchi, Rikiya; Nomura, Wataru; Makishi, Kazuichi; Otsuka, Yuta; Dose, Hitomi; Wanner, Barry L

    2015-01-01

    Here we describe the systematic identification of single genes and gene pairs, whose knockout causes lethality in Escherichia coli K-12. During construction of precise single-gene knockout library of E. coli K-12, we identified 328 essential gene candidates for growth in complex (LB) medium. Upon establishment of the Keio single-gene deletion library, we undertook the development of the ASKA single-gene deletion library carrying a different antibiotic resistance. In addition, we developed tools for identification of synthetic lethal gene combinations by systematic construction of double-gene knockout mutants. We introduce these methods herein. PMID:25636612

  7. Bactericidal effects of photochemical smog constituents produced by a flow reactor. III. Communication: determination of mutagenic effects of photochemical smog on E. coli K 12 343/113.

    PubMed

    Nover, H; Botzenhart, K

    1985-06-01

    The multipurpose strain E. coli K12 343/113 allows the simultaneous detection of different DNA alterations such as base-pair changes, frameshifts and deletions. The investigations show the detection of mutagenic potency in the mixture which is called photochemical smog, produced by a flow reactor. Responsible for these effects were ozone and hydrocarbon-radicals, but not NOx, hydrocarbons (propene, isobutene, trans-2-butene) and peroxiacetylnitrate (PAN). In the given conditions these mutagenic substances are involved in DNA alterations like base-pair changes and deletions due to the amounts of colonies in the gal+-, MTR-, and arg+-system. No frameshifts could be detected in the nad+-system.

  8. Perceptions of Participating K-12 Educational Leaders' Experiences and Decisions Regarding the Crisis Caused by the April 27, 2011 Tornadoes in Rural Alabama

    ERIC Educational Resources Information Center

    Bishop, William E., Jr.

    2013-01-01

    April 27, 2011, will be remembered by many as a catastrophic day and event in Alabama, and specifically by K-12 educational leaders. Natural disasters like tornadoes have a significant impact on leaders, on their decision making and, obviously, on the survival of many of their victims. The possibility and threat of a major crisis caused by natural…

  9. Anxious for Answers: A Meta-Analysis of the E!ects of Anxiety on African American K-12 Students' Mathematics Achievement

    ERIC Educational Resources Information Center

    Young, Jamaal Rashad; Young, Jemimah Lea

    2015-01-01

    Mathematics anxiety is recognized as a significant performance impediment that affects students across multiple ethnic and economic backgrounds. However, research has yet to fully examine the possible differential effect of mathematics anxiety on underrepresented K-12 students. Specifically, given the long-standing achievement gap between African…

  10. Coping with Mandated Restrictions on Intellectual Freedom in K-12 Schools

    ERIC Educational Resources Information Center

    Wolf, Sara

    2008-01-01

    Access to information is an essential art of the educational system. The reality is, however, that there are laws and policies in effect that can restrict what information is available to students and teachers in K-12 schools. Selection policies, Acceptable Use Policies, Circulation Policies, as well as federal laws and acts, all place…

  11. Handbook for Safety Education. A Teacher's Handbook for Safety Education Grades K-12.

    ERIC Educational Resources Information Center

    Walker, Scott V.; And Others

    This handbook is designed to assist classroom teachers and administrators in organizing, planning, and implementing a comprehensive safety program K-12 at the local school or district level. The handbook is organized in three sections. The first section contains 28 units for the elementary level that cover the following topics: first aid training;…

  12. A Look at Research on Mobile Learning in K-12 Education from 2007 to the Present

    ERIC Educational Resources Information Center

    Liu, Min; Scordino, Robert; Geurtz, Renata; Navarrete, Cesar; Ko, Yujung; Lim, Mihyun

    2014-01-01

    The purpose of this literature review is to examine data-based studies published on mobile learning in K-12 from 2007 to the present. In total, 63 studies from 15 refereed journals were selected for analysis. The findings are organized in four themes: (a) comparison studies, (b) no comparison studies, (c) mobilized learning, and (d) academic…

  13. The Debate of Evolution versus Intelligent Design: Is Critical Thinking Occurring among K-12 Students?

    ERIC Educational Resources Information Center

    Hoodman, Kyle Nathan

    2010-01-01

    This study investigates how evolution versus intelligent design is handled in the public, private Christian, private Jewish, and Christian Home-school K-12 settings through a review of the current literature and by interviewing teachers in these educational venues. Fourteen public, private, and homeschool educators responded to an interview…

  14. The Effect of Professional Development on Teacher Attitudes toward Online Learning in K-12 Education

    ERIC Educational Resources Information Center

    Savakinas, Christy A.

    2012-01-01

    The purpose of this study was to examine how teacher attitudes toward online learning in K-12 education vary before, during, and after participation in a professional development program focused on ePedagogy and online course development. The study also examined which Key Design Factors, as identified by Wells (2007), influence teachers'…

  15. Monitoring Progress toward Successful K-12 STEM Education: A Nation Advancing?

    ERIC Educational Resources Information Center

    National Academies Press, 2012

    2012-01-01

    Following a 2011 report by the National Research Council (NRC) on successful K-12 education in science, technology, engineering, and mathematics (STEM), Congress asked the National Science Foundation to identify methods for tracking progress toward the report's recommendations. In response, the NRC convened the Committee on an Evaluation Framework…

  16. Case Study of K-12 Public School Superintendents Having Business Background and No Teaching Experience

    ERIC Educational Resources Information Center

    Novak, James

    2012-01-01

    The purpose of this study was to describe the experiences of superintendents with business backgrounds and who lack teaching experience. There is a shortage of qualified superintendent candidates in K-12 school districts. As a result, some school boards are hiring nontraditional superintendents. This qualitative case study is important because it…

  17. Using Activity Theory to Evaluate and Improve K-12 School and University Partnerships

    ERIC Educational Resources Information Center

    Yamagata-Lynch, Lisa C.; Smaldino, Sharon

    2007-01-01

    This article reports on an evaluation methodology development study for K-12 school and university partnerships. The method is based on Engestrom's (1987). "Learning by expanding: An activity-theoretical approach to developmental research". Helsinki: Orienta-Konsultit Oy activity systems analysis that allows researchers to examine qualitative…

  18. Compilation of K-12 Action Research Papers in Language Arts Education.

    ERIC Educational Resources Information Center

    Sherman, Thomas F.; Lundquist, Margaret

    The papers in this compilation are the result of K-12 action research projects and were submitted in partial fulfillment for a variety of degrees from Winona State University (Minnesota). The compilation contains the following nine papers: "Will Playing Background Music in My Classroom Help Increase Student Spelling Scores?" (Jonathan L. Wright);…

  19. Promising Practices in Information Technology Accessibility in K-12 Education in the Southeast Region

    ERIC Educational Resources Information Center

    Southeast Disability and Business Technical Assistance Center (Southeast DBTAC), 2005

    2005-01-01

    As part of its mission to promote the use of accessible education-based information technology in the Southeast Region, the Southeast Disability and Business Technical Assistance Center (DBTAC) is working with colleges, universities, community colleges and K-12 schools to improve access to information technology for students with disabilities in…

  20. A Review of Resources for Evaluating K-12 Computer Science Education Programs

    ERIC Educational Resources Information Center

    Randolph, Justus J.; Hartikainen, Elina

    2004-01-01

    Since computer science education is a key to preparing students for a technologically-oriented future, it makes sense to have high quality resources for conducting summative and formative evaluation of those programs. This paper describes the results of a critical analysis of the resources for evaluating K-12 computer science education projects.…

  1. Modern Japan: An Idea Book for K-12 Teachers. Multicultural Education Resource Series.

    ERIC Educational Resources Information Center

    Bernson, Mary Hammond, Ed.; Magnusson, Elaine, Ed.

    This idea book of supplementary lessons on Japan is a compilation of lessons produced by elementary and secondary teachers (K-12) at a 1983 summer institute. Lessons offer teaching strategies, factual information, and teaching tips, focusing primarily on writing skills; visual arts; games, music, and other arts; and social studies. The writing…

  2. Preparing University Students to Lead K-12 Engineering Outreach Programmes: A Design Experiment

    ERIC Educational Resources Information Center

    Anthony, Anika B.; Greene, Howard; Post, Paul E.; Parkhurst, Andrew; Zhan, Xi

    2016-01-01

    This paper describes an engineering outreach programme designed to increase the interest of under-represented youth in engineering and to disseminate pre-engineering design challenge materials to K-12 educators and volunteers. Given university students' critical role as facilitators of the outreach programme, researchers conducted a two-year…

  3. U.S. Ed-Tech Plan Urges Rethinking in K-12 Schools

    ERIC Educational Resources Information Center

    Ash, Katie

    2010-01-01

    The Obama administration urged educators and policymakers last week to embrace a host of digital-learning approaches it says will make K-12 schools better, including putting a computing device in the hands of every student. Guided by an overarching goal set by President Barack Obama to raise national college-completion rates from 40 percent to 60…

  4. Technology Counts 2010: Powering Up--Mobile Learning Seeks the Spotlight in K-12 Education

    ERIC Educational Resources Information Center

    Education Week, 2010

    2010-01-01

    Much like the shifting landscape in K-12 educational technology, this year's "Technology Counts" issue is changing to address the challenges of covering schools in the digital age. The 2010 report does not issue state report cards or state policy reports. Instead, the report takes a more district- and school-level look at educational technology.…

  5. A Teaching Guide and Experience Units K-12. Social Studies. Grade Six.

    ERIC Educational Resources Information Center

    Arapahoe County School District 6, Littleton, CO.

    The unit experiences for the K-12 curriculum, including these for grade 6, are outlined in SO 001 139. These units include the study of the culture, history, geography, and economics of regions of Latin American and Canada. Again, the emphasis for both grade 5 and grade 6 is twofold: 1) to know his American heritage, as well as to become aware of…

  6. Science K-12, Conservation of Energy. Utica City School District Articulated Curriculum: Project SEARCH, 1975.

    ERIC Educational Resources Information Center

    Utica City School District, NY.

    Two-column objectives are listed for an integrated science curriculum (Grades K-12), often subheaded according to science area (physical sciences, physics, biology, chemistry, general science) and grade level. Objectives that relate characteristics and forms of energy to energy conservation are stressed in the primary grades (K-6). In grade 7, the…

  7. The SACNAS Biography Project: A Resource for K-12 Educators. [CD-ROM].

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery.

    This CD-ROM was designed as a resource for K-12 educators who are interested in teaching their students about the accomplishments of Chicano/Latino and Native American scientists. Profiles of 48 Latino and Native American scientists, mathematicians, and engineers have been written at the middle school and high school levels and are searchable in…

  8. Integrating the iPod Touch in K-12 Education: Visions and Vices

    ERIC Educational Resources Information Center

    Banister, Savilla

    2010-01-01

    Advocates of ubiquitous computing have long been documenting classroom benefits of one-to-one ratios of students to handheld or laptop computers. The recent sophisticated capabilities of the iPod Touch, iPhone, and iPad have encouraged further speculation on exactly how K-12 teaching and learning might be energized by such devices. This paper…

  9. Status of K-12 Education in California at a Time of Fiscal Crisis: Preliminary Results

    ERIC Educational Resources Information Center

    Kitmitto, Sami; Parrish, Thomas; Shambaugh, Larisa

    2010-01-01

    The worldwide economic decline in 2008 hit many states hard, and had an especially strong impact on California and its public education system. The purpose of this report is to develop and present baseline information regarding K-12 public education in California prior to this fiscal crisis. This report presents alternative ways of comparing the…

  10. Development of Design Guidance for K-12 Schools from 30% to 50% Energy Savings: Preprint

    SciTech Connect

    Pless, S.; Torcellini, P.; Long, N.

    2008-07-01

    This paper describes the development of energy efficiency recommendations for achieving 30% whole-building energy savings in K-12 schools over levels achieved by following the ANSI/ASHRAE/IESNA Standard 90.1. These design recommendations look at building envelope, fenestration, lighting systems (including electrical lights and daylighting), HVAC systems, building automation and controls, outside air treatment, and service water heating.

  11. Global Educational Ecosystem: Case Study of a Partnership with K-12 Schools, Community Organizations, and Business

    ERIC Educational Resources Information Center

    Lewis, Donna S.

    2010-01-01

    The purpose of this study was to describe a collaborative partnership model known as the Global Educational Ecosystem, which involves three K-12 schools in Northern California, community organizations (representing science, technology, health, and arts), and Xilinx, Inc. from the perspectives of the leaders of the involved partner organizations in…

  12. Science K-12, Conservation of Matter. Utica City School District Articulated Curriculum: Project SEARCH, 1975.

    ERIC Educational Resources Information Center

    Utica City School District, NY.

    Two-column objectives are listed for an integrated science curriculum (grades K-12), often subheaded according to science area (biology, general science, physical science) and grade level. The focus of grades K-6 is an acquaintance of the student to: (1) the study of matter, its states, characteristics and properties, (2) structure of the atom,…

  13. Tech-Savvy Science Education? Understanding Teacher Pedagogical Practices for Integrating Technology in K-12 Classrooms

    ERIC Educational Resources Information Center

    Hechter, Richard; Vermette, Laurie Anne

    2014-01-01

    This paper examines the technology integration practices of Manitoban K-12 inservice science educators based on the Technological, Pedagogical, and Content knowledge (TPACK) framework. Science teachers (n = 433) completed a 10-item online survey regarding pedagogical beliefs about technology integration, types of technology used, and how often…

  14. A Mixed Methods Case Study of the Levels of Interactive Whiteboard Use by K-12 Teachers

    ERIC Educational Resources Information Center

    Thomas, Jo Ann

    2014-01-01

    The growing presence of educational technology in our nation's K-12 schools has had little effect on teacher practices to enhance student learning (Once, Delialioglu, & Brown, 2008). Sophisticated levels of educational technology use are believed to influence student learning (Hall, Loucks, Rutherford, & Newlove, 1975) yet research on…

  15. Solving Behavior Problems in Math Class: Academic, Learning, Social, and Emotional Empowerment (Grades K-12)

    ERIC Educational Resources Information Center

    Taylor-Cox, Jennifer

    2011-01-01

    Reduce the number of discipline issues that arise in your math classroom with ideas from math education expert Jennifer Taylor-Cox. In this book, you'll learn a variety of ways to handle disruptive, disinterested, avoidant, and/or disrespectful students in K-12 math classrooms. Using realistic, case-by-case examples, the author reveals practical…

  16. A Model for Incorporating Content on Aging into the Curriculum: K-12.

    ERIC Educational Resources Information Center

    Blackwell, David L.; Hunt, Sara Stockard

    Following a statement of the problem of putting aging education in the elementary secondary curriculum, and a review of the relevant literature, a model for developing a curriculum on aging is presented. An overview of the 3-year project, developed in Baton Rouge, Louisiana schools for grades K-12, is offered, including activities and yearly…

  17. Going against the Grain: Challenges to Peaceful Leadership Styles in a K-12/University Partnership

    ERIC Educational Resources Information Center

    Carson, Susan; Chandler, Susanne; Collins, Elaine C.; Snow, Debbie; Williams, Jerri-Lynn

    2010-01-01

    This article shares and examines the challenges, findings, and lessons learned associated with embracing peaceful leadership styles during the first two years of a partnership between a failing K-12 urban school district and a university in the United States. The ongoing daily leadership issues that influenced, but were beyond the scope of, the…

  18. Makerspaces: The Next Iteration for Educational Technology in K-12 Schools

    ERIC Educational Resources Information Center

    Strycker, Jesse

    2015-01-01

    With the continually growing number of computers and mobile devices available in K-12 schools, the need is dwindling for dedicated computer labs and media centers. Some schools are starting to repurpose those facilities into different kinds of exploratory learning environments known as "makerspaces". This article discusses this next…

  19. California K-12 Schools and Communities Collaborate to Support Student Mental Health

    ERIC Educational Resources Information Center

    Woodbridge, Michelle W.; Goldweber, Asha; Yu, Jennifer; Golan, Shari; Stein, Bradley D.

    2013-01-01

    Across the education, public health, and human and social services areas, there is renewed interest in bringing agency representatives together to work on the promotion of student mental health and wellness. One of the aims of California's Prevention and Early Intervention (PEI) K-12 Student Mental Health (SMH) initiative funded under Proposition…

  20. Reconsidering Genre Theory in K-12 Schools: A Response to School Reforms in the United States

    ERIC Educational Resources Information Center

    Gebhard, Meg; Harman, Ruth

    2011-01-01

    Education reforms in the United States have placed new demands on English language learners (ELLs) and their teachers in K-12 public schools. In response, many teachers, teacher educators, and literacy scholars are reexamining genre theory and genre-based pedagogy as a way of supporting the academic literacy development of the growing number of…

  1. Introducing Algebraic Structures through Solving Equations: Vertical Content Knowledge for K-12 Mathematics Teachers

    ERIC Educational Resources Information Center

    Wasserman, Nicholas H.

    2014-01-01

    Algebraic structures are a necessary aspect of algebraic thinking for K-12 students and teachers. An approach for introducing the algebraic structure of groups and fields through the arithmetic properties required for solving simple equations is summarized; the collective (not individual) importance of these axioms as a foundation for algebraic…

  2. NGSS and the Landscape of Engineering in K-12 State Science Standards

    ERIC Educational Resources Information Center

    Moore, Tamara J.; Tank, Kristina M.; Glancy, Aran W.; Kersten, Jennifer A.

    2015-01-01

    Recent documents pertaining to K-12 education have fostered a connection between engineering and science education to help better prepare our students and future citizens to better meet the current and future challenges of our modern and technological society. With that connection, there has been a concerted effort to raise the visibility of…

  3. State Capacity to Link K-12/Postsecondary Data Systems and Report Key Indicators

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2016

    2016-01-01

    The Every Student Succeeds Act (ESSA) provides an opportunity to produce high quality postsecondary indicators and, as available, publicly report them in ways that inform, engage, and empower communities. As first "required" in 2009's American Recovery and Reinvestment Act (ARRA) stimulus law, almost every state has linked its K-12 and…

  4. When Professions Shape Politics: The Case of Accountability in K-12 and Higher Education

    ERIC Educational Resources Information Center

    Mehta, Jal

    2014-01-01

    Professionalization is an important but overlooked dimension in education politics, particularly the politics of accountability. To isolate the importance of professionalization, this article compares accountability movements in K-12 education with similar movements in higher education. I draw on three pairs of reports that have sought to impose…

  5. Encouraging and Supporting Electronic Communication across the Curriculum (ECAC) through a University and K-12 Partnership.

    ERIC Educational Resources Information Center

    DeVoss, Danielle Nicole; Selfe, Dickie

    2002-01-01

    Presents an approach to remedying the technological turbulence that both k-12 and university faculty face. Describes the Electronic Communication Across the Curriculum Summer Workshop. Offers this workshop as a model approach for other workshop developers, for those interested in educational partnerships, and for those committed to professional…

  6. Industrial Enterprise Handbook. The Wisconsin Guide to Local Curriculum Improvement in Industrial Education, K-12.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Div. of Instructional Services.

    This handbook is designed to aid industrial educators in developing a private enterprise component in their programs in order to help students learn how business and industry work. It is a guide to implementing The Wisconsin Guide to Local Curriculum Improvement in Industrial Education, K-12. The book contains the following three sections: (1)…

  7. How to Launch an Energy Star Energy Efficiency Competition for K-12 Schools

    ERIC Educational Resources Information Center

    Utebay Kudret; McArthur, Ashley

    2012-01-01

    In recent years, schools have been forced by rising costs and shrinking budgets to stretch their resources further than ever before in order to meet the educational needs of today's students. EPA's ENERGY STAR program helps K-12 schools and districts improve energy efficiency, reduce operating costs and redirect critical resources into the…

  8. The Keys for ICT Integration in K-12 Education: Teachers' Perceptions and Usage

    ERIC Educational Resources Information Center

    Goktas, Yuksel; Yildirim, Zahide; Yildirim, Soner

    2008-01-01

    The purpose of this study is to investigate the current status of K-12 teachers' Information and Communication Technologies (ICT) perceptions and ICT usage in their courses. The researchers used both quantitative and qualitative research approaches within data collection and analysis section. Quantitative data were collected with a questionnaire…

  9. Can an Electronic Textbooks Be Part of K-12 Education?: Challenges, Technological Solutions and Open Issues

    ERIC Educational Resources Information Center

    Lee, HeeJeong Jasmine; Messom, Chris; Yau, Kok-Lim Alvin

    2013-01-01

    An electronic textbook (e-Textbook) is a digitized (or electronic) form of textbook, which normally needs an endorsement by the national or state government when it is used in the K-12 education system. E-Textbooks have been envisioned to replace existing paper-based textbooks due to its educational advantages. Hence, it is of paramount importance…

  10. Efficacy of Webinar Training for Continuing Professional Education: Applications for School Personnel in K-12 Settings

    ERIC Educational Resources Information Center

    Covington, Julie Anne

    2012-01-01

    The purpose of the researcher was to evaluate the effectiveness of webinar training for K-12 school personnel in childhood obesity prevention tools and resources provided by the North Carolina Prevention Partners (NCPP). A mixed method sequential research design was used to evaluate the training across the first three levels of the Kirkpatrick…

  11. Development of Problem Sets for K-12 and Engineering on Pharmaceutical Particulate Systems

    ERIC Educational Resources Information Center

    Savelski, Mariano J.; Slater, C. Stewart; Del Vecchio, Christopher A.; Kosteleski, Adrian J.; Wilson, Sarah A.

    2010-01-01

    Educational problem sets have been developed on structured organic particulate systems (SOPS) used in pharmaceutical technology. The sets present topics such as particle properties and powder flow and can be integrated into K-12 and college-level curricula. The materials educate students in specific areas of pharmaceutical particulate processing,…

  12. ENGLISH AND THE LANGUAGE ARTS, A CURRICULUM GUIDE FOR GRADES K-12.

    ERIC Educational Resources Information Center

    Wyoming State Dept. of Education, Cheyenne.

    THE ENGLISH CURRICULUM GUIDE FOR GRADES K-12, ISSUED BY THE WYOMING STATE DEPARTMENT OF EDUCATION, IS BUILT AROUND TWO MAIN IDEAS--(1) THAT A LASTING EDUCATION DEVELOPS DELIGHT IN GOOD READING, WRITING, SPEAKING, AND LISTENING, AND (2) THAT LANGUAGE NOT ONLY COMMUNICATES OUR THOUGHTS AND IMPRESSIONS, BUT ALSO HELPS TO PRODUCE AND SHAPE THEM. THE…

  13. Blueprint for Incorporating Service Learning: A Basic, Developmental, K-12 Service Learning Typology

    ERIC Educational Resources Information Center

    Terry, Alice W.; Bohnenberger, Jann E.

    2004-01-01

    Citing the need for a basic, K-12 developmental framework for service learning, this article describes such a model. This model, an inclusive typology of service learning, distinguishes three levels of service learning: Community Service, Community Exploration, and Community Action. The authors correlate this typology to Piaget's cognitive…

  14. Addressing the Nets for Students through Constructivist Technology Use in K-12 Classrooms

    ERIC Educational Resources Information Center

    Niederhauser, Dale S.; Lindstrom, Denise L.

    2006-01-01

    The National Educational Technology Standards for Students promote constructivist technology use for K-12 students in U.S. schools. In this study, researchers reported on 716 cases in which teachers described technology-based activities they conducted with their students. Narrative analysis was used to examine case transcripts relative to the…

  15. Measurement Invariance of the "Servant Leadership Questionnaire" across K-12 Principal Gender

    ERIC Educational Resources Information Center

    Xu, Lihua; Stewart, Trae; Haber-Curran, Paige

    2015-01-01

    Measurement invariance of the five-factor "Servant Leadership Questionnaire" between female and male K-12 principals was tested using multi-group confirmatory factor analysis. A sample of 956 principals (56.9% were females and 43.1% were males) was analysed in this study. The hierarchical multi-step measurement invariance test supported…

  16. Focus on People--The Native American: A Multimedia Bibliography K-12.

    ERIC Educational Resources Information Center

    Crutchfield, Regina K., Comp.; Worsley, Charles, Comp.

    The selective bibliography of 383 currently available resource materials is to be used as a guide for the purpose of selecting grade K-12 instructional materials by and about American Indians that will help children attain positive self images. The books, records, cassettes, transparencies, kits, charts, maps, filmstrips, slides, and games listed…

  17. Students Doing Chemistry: A Hand-On Experience for K-12

    ERIC Educational Resources Information Center

    Selco, Jodye I.; Bruno, Mary; Chan, Sue

    2012-01-01

    A hands-on, minds-on inquiry chemistry experiment was developed for use in K-12 schools that enables students to combine the chemicals of their choice and observe the results. The chemistry involved is water based and builds upon acid-base, double displacement, and iodometric detection of starch reactions. Chemicals readily available in the…

  18. Accountability and Assessment: Is Public Interest in K-12 Education Being Served? CRESST Report 728

    ERIC Educational Resources Information Center

    Herman, Joan L.

    2007-01-01

    The reauthorization of No Child Left Behind (NCLB) makes this a good time to consider whether and how current accountability serves the public interest and whether and how it can better do so. This report explores these issues in the context of the current literature on the effects of accountability in K-12 education. It considers the meaning…

  19. The Internet Resource Directory for K-12 Teachers and Librarians, 95/96 Edition.

    ERIC Educational Resources Information Center

    Miller, Elizabeth B.

    This directory is the second in an annual series of Internet guides for educators and librarians, and provides tips on access to, as well as addresses for, online resources that support the K-12 curriculum and supplement school library core collections. The listings in the catalog are limited to free and frequently updated resources; over 300 new…

  20. The Internet Resource Directory for K-12 Teachers and Librarians. 97/98 Edition.

    ERIC Educational Resources Information Center

    Miller, Elizabeth B.

    This directory is the fourth in an annual series of Internet guides for educators, librarians, and school administrators, and provides tips on access to, as well as addresses for, online resources that support and enrich the K-12 curriculum and supplement the school library core collection. Sites that help educators develop professionally are also…

  1. Addressing the NETS*S in K-12 Classrooms: Implications for Teacher Education

    ERIC Educational Resources Information Center

    Niederhauser, Dale S.; Lindstrom, Denise L.; Strobel, Johannes

    2007-01-01

    The National Educational Technology Standards for Students (NETS*S) were developed to provide guidelines for effective and meaningful technology use with K-12 students. In the present study we used the NETS*S as a framework to analyze ways that teachers integrated instructional technology use and provided opportunities for their students to…

  2. Development of a Virtual Technology Coach to Support Technology Integration for K-12 Educators

    ERIC Educational Resources Information Center

    Sugar, William; van Tryon, Patricia J. Slagter

    2014-01-01

    In an effort to develop a virtual technology coach for K-12 educators, this article analyzed survey results from sixty teachers with regards to specific resources that a technology coach could provide within a virtual environment. A virtual technology coach was proposed as a possible solution to provide continual professional development for…

  3. District Leadership for Science Education: Using K-12 Departments to Support Elementary Science Education under NCLB

    ERIC Educational Resources Information Center

    Miller, Christopher L.

    2010-01-01

    By contrasting two case studies of school districts, this paper illustrates the effectiveness of K-12 science departments in supporting elementary science education, especially in response to NCLB's push towards the articulation of curriculum across all grades and as a response to the erosion of instructional time on science in elementary schools…

  4. Perceptions of Educational Barriers Affecting the Academic Achievement of Latino K-12 Students

    ERIC Educational Resources Information Center

    Becerra, David

    2012-01-01

    This study examined different factors affecting the perceptions of barriers in academic achievement of Latino K-12 students. The study used data from 1,508 participants who identified themselves as being of Hispanic or Latino heritage in the 2004 National Survey of Latinos: Education, compiled by the Pew Hispanic Center between August 7 and…

  5. K-12 Parents' Attitudes about Their School District's Mass Notification Service

    ERIC Educational Resources Information Center

    Downing, Joe R.

    2011-01-01

    The study examined K-12 parents' attitudes about their school district's mass notification service. Survey data were collected from 146 parents with at least one child who attended school in the district. During an emergency, most parents surveyed wanted their district to expand its mass notification service from landline phone only to also…

  6. Black Educational Choice: Assessing the Private and Public Alternatives to Traditional K-12 Public Schools

    ERIC Educational Resources Information Center

    Slaughter-Defoe, Diana T., Ed.; Stevenson, Howard C., Ed.; Arrington, Edith G., Ed.; Johnson, Deborah J., Ed.

    2011-01-01

    This important book provides African American parents with the knowledge to diversify K-12 school choices beyond traditional neighborhood public schools in order to optimize the educational chances of their own children, and it will help educators and policymakers to close the black-white academic achievement gap throughout America. In November…

  7. How Do School Districts Treat K-12 Principals and Principal Candidates with Online Credentials?

    ERIC Educational Resources Information Center

    Richardson, Jayson W.; McLeod, Scott; Dikkers, Amy Garrett

    2011-01-01

    This study was designed to understand how school districts treat their current principals and principal candidates who have taken online courses or who have earned online degrees. Through a survey of 105 human resources directors in K-12 schools across the USA, the study found five major themes: (1) districts are reluctant to hire principals with…

  8. A Correlational Analysis of Strategic Information Systems Planning in K-12 Public Educational Organizations

    ERIC Educational Resources Information Center

    Martin, Christopher J.

    2012-01-01

    Three decades of research has indicated that strategic information systems planning is a vital component to business success. The purpose of this study was to identify the relationship strategic information systems planning and financial commitment has within the K-12 public education sector. Data for this study was obtained from top management of…

  9. Leading by Following: An Analysis of How K-12 School Leaders Use Twitter

    ERIC Educational Resources Information Center

    Sauers, Nicholas J.; Richardson, Jayson W.

    2015-01-01

    This study analyzed how active Twitter users who are also school leaders used the tool. The researchers collaboratively identified K-12 school leaders who were active on Twitter and then collected tweets from those school leaders. The final sample for this study included 115 Twitter users and over 180,000 tweets from those individuals. The results…

  10. Leading Effective Educational Technology in K-12 School Districts: A Grounded Theory

    ERIC Educational Resources Information Center

    Hill, Lara Gillian C.

    2011-01-01

    A systematic grounded theory qualitative study was conducted investigating the process of effectively leading educational technology in New Jersey public K-12 school districts. Data were collected from educational technology district leaders (whether formal or non-formal administrators) and central administrators through a semi-structured online…

  11. An Empirical Evaluation of Distance Learning's Effectiveness in the K-12 Setting

    ERIC Educational Resources Information Center

    Harris-Packer, Jerilyn D.; Ségol, Geneviève

    2015-01-01

    This study evaluated the effect of online instruction on the academic achievement of K--12 students in ten states as measured by the percentage of proficient students in reading and mathematics at the school level. We used publicly available data provided by the Department of Education in Florida, Michigan, Minnesota, Nevada, Ohio, Pennsylvania,…

  12. K-12 Mathematics: What Should Students Learn and When Should They Learn It? Conference Highlights

    ERIC Educational Resources Information Center

    Center for the Study of Mathematics Curriculum, 2007

    2007-01-01

    In the fall of 2006 several influential national groups (Achieve, American Statistical Association, College Board, and the National Council of Teachers of Mathematics) developed and released documents that recommended curriculum standards or focal points for K-12 mathematics. The timing of the release of these documents provided a unique and…

  13. K-12 Race-Conscious Student Assignment Policies: Law, Social Science, and Diversity

    ERIC Educational Resources Information Center

    Welner, Kevin G.

    2006-01-01

    This fall, the Supreme Court will consider the constitutionality of raceconscious K-12 student assignment policies. At a time when schools nationwide have become more racially isolated, some districts have used such policies to mitigate segregation. This article examines these policies in light of the Supreme Court's recent decisions concerning…

  14. Teacher Field Research Experiences: Building and Maintaining the Passion for K-12 Science Education

    NASA Astrophysics Data System (ADS)

    Dunton, K.; Schonberg, S.

    2006-12-01

    Academic scientists and researchers are increasingly encouraged to develop connections with K-12 educators to promote scientific literacy and bring excitement into the classroom. Such partnerships carry long-term benefits to both teachers and researchers. Teachers gain the tools, confidence, and knowledge to develop research activities with their students that promote scientific inquiry, and researchers benefit from outreach activities that improve communication skills for sharing scientific knowledge with the public. Our K-12 programs have been field based under a theme of Classrooms Without Walls, to take advantage of our local marine environment and a long-term research program on the Alaskan Arctic coast. Our professional development programs for teachers have included the creation of an annual summer graduate level course (Application of Field Research Experiences for K-12 Science and Math Educators) as an introduction to scientific methodology, observation, and inquiry based learning. We provide graduate students as resources in classrooms and for field trip experiences and provide supplies and instrumentation to teachers for K-12 field projects. Finally, teachers have an opportunity to join our researchers to remote sites under various competitive programs that receive federal support (e.g. GK-12, ARMADA). We provide examples of our activities, which are based on recent needs assessment surveys of science teachers; these included development of content knowledge and providing students with opportunities to connect concepts with experiences. Our goal is to provide field experiences to teachers and students that enable them to relate science concepts to the real world.

  15. Formative Evaluation of Bugscope: A Sustainable World Wide Laboratory for K-12.

    ERIC Educational Resources Information Center

    Thakkar, U.; Carragher, B.; Carroll, L.; Conway, C.; Grosser, B.; Kisseberth, N.; Potter, C. S.; Robinson, S.; Sinn-Hanlon, J.; Stone, D.; Weber, D.

    Bugscope is an emerging educational technology project that allows students and teachers across grades K-12 to study insects and other arthropods through remote access and control of an environmental scanning electron microscope from their classroom computers. Teachers and students in 33 schools from 18 states and the U.S. Virgin Islands were…

  16. Implementing Observation Protocols: Lessons for K-12 Education from the Field of Early Childhood

    ERIC Educational Resources Information Center

    Pianta, Robert C.

    2012-01-01

    This report draws from decades of experience using observation in early childhood education, which has implications for administrative decisions, evaluation practices, and policymaking in K-12. Early childhood education has long embraced the value of observing classrooms and teacher-child interactions. In early childhood education the features of…

  17. An Exploratory Essay on Listening Instruction in the K-12 Curriculum

    ERIC Educational Resources Information Center

    Hopper, Joanne E.

    2007-01-01

    Even though the importance of effective listening skills is well recognized and many K-12 language arts standards include listening skills, the amount of time devoted to the teaching of listening and the quality of instructional resources that will enable the effectiveness of teaching listening as a two-way communication process are in question.…

  18. Using the van Hiele K-12 Geometry Learning Theory to Modify Engineering Mechanics Instruction

    ERIC Educational Resources Information Center

    Sharp, Janet M.; Zachary, Loren W.

    2004-01-01

    Engineering students use spatial thinking when examining diagrams or models to study structure design. It is expected that most engineering students have solidified spatial thinking skills during K-12 schooling. However, according to what we know about geometry learning and teaching, spatial thinking probably needs to be explicitly taught within…

  19. A Study of the Tablet Computer's Application in K-12 Schools in China

    ERIC Educational Resources Information Center

    Long, Taotao; Liang, Wenxin; Yu, Shengquan

    2013-01-01

    As an emerging mobile terminal, the tablet computer has begun to enter into the educational system. With the aim of having a better understanding of the application and people's perspectives on the new technology in K-12 schools in China, a survey was conducted to investigate the tablet computer's application, user's perspectives and requirements…

  20. Students as Library Detectives and Books as Clues: An Application of ISD in K-12 Schools

    ERIC Educational Resources Information Center

    Moore, Kimberly J.; Knowlton, Dave S.

    2006-01-01

    Instructional Systems Design (ISD) is the systematic development of instructional strategies that are grounded in both learning and instructional theory. ISD is usually overlooked as a useful methodology in K-12 schools. ISD is extremely expensive in terms of the time required to develop instruction, and it often seems more appropriate as an…

  1. Connecting the Dots: Postsecondary's Role in Preparing K-12 Students

    ERIC Educational Resources Information Center

    Partnership for Assessment of Readiness for College and Careers, 2012

    2012-01-01

    For the first time in the nation's history 46 States and the District of Columbia have agreed that all K-12 students will be educated along a common continuum of high academic expectations known as the Common Core State Standards (CCSS). Having clear, consistent standards in English language arts/literacy and mathematics will help ensure that…

  2. Urban Teaching in America: Theory, Research, and Practice in K-12 Classrooms

    ERIC Educational Resources Information Center

    Stairs, Andrea J.; Donnell, Kelly A.; Dunn, Alyssa Hadley

    2011-01-01

    "Urban Teaching in America: Theory, Research, and Practice in K-12 Classrooms" is a brief yet comprehensive overview of urban teaching. Undergraduate and graduate students who are new to the urban context will develop a deeper understanding of the urban teaching environment and the challenges and opportunities they can expect to face while…

  3. Handbook for Speech Correction, Grades K-12. Curriculum Bulletin 1973-74, Series Number 6.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Bureau of Curriculum Development.

    The handbook describes the speech correction program of the New York City school system (Grades K-12), outlines the duties and responsibilities of the speech teacher, and presents guidelines, resource materials and lesson plans for use with speech handicapped students. Covered in the first three chapters are aspects of program organization (such…

  4. Mixed Methods Evaluation of Statewide Implementation of Mathematics Education Technology for K-12 Students

    ERIC Educational Resources Information Center

    Brasiel, Sarah; Martin, Taylor; Jeong, Soojeong; Yuan, Min

    2016-01-01

    An extensive body of research has demonstrated that the use in a K-12 classroom of technology, such as the Internet, computers, and software programs, enhances the learning of mathematics (Cheung & Slavin, 2013; Cohen & Hollebrands, 2011). In particular, growing empirical evidence supports that certain types of technology, such as…

  5. Science K-12. Teacher Handbook. North Carolina Competency-Based Curriculum Subject-by-Subject.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Instructional Services.

    An integrated competency-based course of study in the sciences is provided in the handbook for North Carolina teachers of grades K-12. Recommended goals, objectives, and suggested measures for each subject and skill area related to the sciences are outlined. This guide contains: (1) an introduction (defining North Carolina's basic educational…

  6. Handbook of Research on Literacy in Technology at the K-12 Level

    ERIC Educational Resources Information Center

    Hin, Leo Tan Wee, Ed.; Subramaniam, R., Ed.

    2006-01-01

    The "Handbook of Research on Literacy in Technology at the K-12 Level" is the first reference work to provide comprehensive coverage of the issues, methods, and theories that define the converging worlds of literacy and technology at the pre-collegiate level. Over 50 international experts have combined their research and practical experience into…

  7. K-12 Online and Blended Teacher Licensure: Striking a Balance between Policy and Preparedness

    ERIC Educational Resources Information Center

    Archambault, Leanna; DeBruler, Kristen; Freidhoff, Joseph

    2014-01-01

    As the number of K-12 students participating in various forms of online learning steadily rises, teacher quality is of paramount concern. This article explores the theoretical underpinnings surrounding quality teaching in online settings as well as practical considerations for what teachers should know and be able to do in online environments.…

  8. Comparing Cross-Cultural Multicultural Self-Awareness among K-12 In-Service School Teachers

    ERIC Educational Resources Information Center

    Koyama, Chieko; Plash, Shawn; Davis, Kirk

    2012-01-01

    The present study explored multicultural self-awareness among 134 K-12 in-service school teachers using the Cultural Diversity Awareness Inventory (CDAI). The results were compared to Yeung's (2006), allowing for a comparison between Eastern and Western cultures. A composite score was generated for each of the five areas measured by the CDAI. A…

  9. An Investigation of PreK-12 Educators' Information Needs and Search Behaviors on the Internet.

    ERIC Educational Resources Information Center

    Small, Ruth V.; Sutton, Stuart; Eisenberg, Michael; Miwa, Makiko; Urfels, Claire

    The Internet contains a vast array of educational resources, ranging from individual activities to whole curricula. This research study used content analyses and an electronic questionnaire to investigate how and why PreK-12 educators use information from the Internet for instructional design purposes in order to inform the design of an…

  10. Information Literacy Skills for Preservice Teachers: Do They Transfer to K-12 Classrooms?

    ERIC Educational Resources Information Center

    Stockham, Marcia; Collins, Heather

    2012-01-01

    This study surveyed current education majors (n=70) in two Kansas universities to gain a perspective on their understanding of Information Literacy (IL) concepts and skills, and to learn whether they anticipated teaching such concepts to their future K-12 students. School media specialists in the state were also surveyed (n=85) and asked to share…

  11. K-12 Online Lesson Alignment to the Principles of Universal Design for Learning: The Khan Academy

    ERIC Educational Resources Information Center

    Smith, Sean J.; Harvey, Evelyn E.

    2014-01-01

    The field of K-12 education is being transformed, with an influx of students, including those with identified disabilities, engaging in blended and fully online learning. While online learning shows promise for students with disabilities through flexible content and personalised instruction, concerns regarding accessibility and appropriateness of…

  12. Be a Water Watcher: A Resource Guide for Water Conservation, K-12.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    This is a resource guide (in response to the New York City water emergency) for grades K-12 on the subject of water conservation. Activities are suggested for science, industrial arts, social studies, and communications arts classes. A bibliography on water is also provided. (APM)

  13. Testing the Economic Literacy of K-12 Teachers: A State-Wide Baseline Analysis

    ERIC Educational Resources Information Center

    Grimes, Paul W.; Millea, Meghan J.; Thomas, M. Kathleen

    2010-01-01

    Without a Council for Economic Education affiliated state council, Mississippi lacked a formal economic education advocate for more than two decades. A new state council along with two university-based centers have recently undertaken an aggressive push to elevate the role and importance of economics in Mississippi's K-12 school systems. This…

  14. A Study of White Privilege in K-12 Schools: Minority Teachers' Perspectives

    ERIC Educational Resources Information Center

    Christman, Kristen Pope Thompson

    2013-01-01

    The purpose of this dissertation is to capture and explore the existence of white privilege in K-12 schools through the perspective of minority educators. Further, my hope is to engage educators of all kind to begin conversations about white privilege in the schools; to deconstruct whiteness and its impact on education. This research brings forth…

  15. Indiana's New and (Somewhat) Improved K-12 School Finance System. School Choice Issues in the State

    ERIC Educational Resources Information Center

    Aud, Susan L.

    2005-01-01

    Education finance policy has become an urgent concern in many state legislatures. Demands for greater equity and accountability have forced states to review, and in many cases to revise, the method by which schools are funded. This study sheds light on Indiana's financing of public K-12 education by providing a clear explanation of the components…

  16. Perceptions and Experiences of K-12 Educational Leaders in Response to the 27 April 2011 Tornadoes

    ERIC Educational Resources Information Center

    Bishop, William E.; Fifolt, Matthew; Peters, Gary B.; Gurley, D. Keith; Collins, Loucrecia

    2015-01-01

    The purpose of this phenomenological study was to capture first-hand accounts of K-12 educational leaders whose school districts were directly affected by the deadly 27 April 2011 tornadoes in rural Alabama, USA. This study was framed by the literature base of leadership; specifically crisis leadership and resilience theory. Findings are organised…

  17. Faculty Designers and Instructional Design Skills for Developing Learning Opportunities in K-12 Environments

    ERIC Educational Resources Information Center

    Nativio, Alaine

    2014-01-01

    As K-12 environments discover different avenues to offer the best learning experiences available to students, schools are utilizing existing staff members to develop and teach traditional face-to-face, blended and online courses. The purpose of the study was to discover similarities and differences in processes, principles and strategies for…

  18. Teacher Perceptions of Parenting at a Private Pre K-12 School

    ERIC Educational Resources Information Center

    Malone, Terrence

    2011-01-01

    This study investigated the impact of parenting trends on a private Pre K-12 school from the Midwestern United States. The researcher used focus group interviews with 16 educators to examine the perceived effects of parenting on teachers, students and the institution. Results from a survey, reaching a larger sample of educators from two additional…

  19. Open Online System Adoption in K-12 as a Democratising Factor

    ERIC Educational Resources Information Center

    Kimmons, Royce

    2015-01-01

    This study seeks to understand how district size and wealth factors influence the adoption of open-source online systems in primary and secondary (K-12) education. Most schools now utilise online systems (e.g. CMS, LMS, SIS) for a number of purposes, and it is anticipated that no-cost and open-source systems could be of great value for…

  20. Impact of Guided Notes on Achievement in K-12 and Special Education Students

    ERIC Educational Resources Information Center

    Larwin, Karen H.; Dawson, Daniel; Erickson, Matthew; Larwin, David A.

    2012-01-01

    The common practice of using of guided notes in the K-12 and special education classroom is not fully appreciated or understood. In an effort to add to the existing research about this phenomenon, the current investigation expands on previously published research and one previously published meta-analysis that examined the impact of guided notes…

  1. Technology Integration in K-12 Geography Education Using TPACK as a Conceptual Model

    ERIC Educational Resources Information Center

    Doering, Aaron; Koseoglu, Suzan; Scharber, Cassie; Henrickson, Jeni; Lanegran, David

    2014-01-01

    There is a need for quality professional development programs and instructional models addressing the needs and challenges of K-12 technology integration in the geography classroom. This study used a mixed-methods design employing surveys and observations to evaluate teacher experiences within a professional development program focused on…

  2. Evaluating ICT Integration in Turkish K-12 Schools through Teachers' Views

    ERIC Educational Resources Information Center

    Aydin, Mehmet Kemal; Gürol, Mehmet; Vanderlinde, Ruben

    2016-01-01

    The current study aims to explore ICT integration in Turkish K-12 schools purposively selected as a representation of F@tih and non-F@tih public schools together with a private school. A convergent mixed methods design was employed with a multiple case strategy as such it will enable to make casewise comparisons. The quantitative data was…

  3. Curriculum Guide for Music Education, K-12. Bulletin 1978, No. 18.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery.

    This curriculum guide contains objectives, activities, and evaluation procedures for a K-12 music education program. It would be useful to anyone responsible for teaching music. The authors believe that music education has the dual obligation of developing the aesthetic sensitivity of all students regardless of their individual levels of musical…

  4. Writing Changes in the Nation's K-12 Education System. Research Notes RN-34

    ERIC Educational Resources Information Center

    Noeth, Richard J.; Kobrin, Jennifer L.

    2007-01-01

    The purpose of this study was to learn whether there have been any changes in writing instruction across K-12 education in the past three years. A three-year time frame was chosen to structure the study as it included the time period subsequent to the College Board's first announcement of the SAT writing section (the 2002-03 academic year). The…

  5. California and the "Common Core": Will There Be a New Debate about K-12 Standards?

    ERIC Educational Resources Information Center

    EdSource, 2010

    2010-01-01

    A growing chorus of state and federal policymakers, large foundations, and business leaders across the country are calling for states to adopt a common, rigorous body of college- and career-ready skills and knowledge in English and mathematics that all K-12 students will be expected to master by the time they graduate. This report looks at the…

  6. Economics America: Content Statements for State Standards in Economics, K-12.

    ERIC Educational Resources Information Center

    National Council on Economic Education, New York, NY.

    This updated list of content standards covering economics is suggested for states developing their own economics standards. The list outlines the core requirements for basic literacy in economics for grades K-12. The statements are similar to designated content standards from other core subject areas. Key economic concepts describing their basic…

  7. Mobile Apps for Reflection in Learning: A Design Research in K-12 Education

    ERIC Educational Resources Information Center

    Leinonen, Teemu; Keune, Anna; Veermans, Marjaana; Toikkanen, Tarmo

    2016-01-01

    This study takes a design-based research approach to explore how applications designed for mobile devices could support reflection in learning in K-12 education. Use of mobile devices is increasing in schools. Most of the educational apps support single-person use of interactive learning materials, simulations and learning games. Apps designed to…

  8. An Exploratory Study of the Ascendancy of Women to the Position of K-12 Superintendent

    ERIC Educational Resources Information Center

    Hanson, Karen M.

    2011-01-01

    Despite earning over half of the doctoral degrees in education, women are underrepresented in the position of K-12 superintendent. In 2000, although 72% of all classroom teachers were female, only 14% of all superintendents in the United States were women. Research indicates that women experience barriers in their ascendancy to superintendent.…

  9. Are K-12 Learners Motivated in Physical Education? A Meta-Analysis

    ERIC Educational Resources Information Center

    Chen, Senlin; Chen, Ang; Zhu, Xihe

    2012-01-01

    Previous studies devoted to K-12 learner motivation in physical education share a general assumption that students may lack motivation. This meta-analytic study examined published original studies (n = 79) to determine students' motivation level and the association between motivation and outcomes. Original means of motivation measures were…

  10. Impact of an Education Intervention on Missouri K-12 School Disaster and Biological Event Preparedness

    ERIC Educational Resources Information Center

    Rebmann, Terri; Elliott, Michael B.; Artman, Deborah; VanNatta, Matthew; Wakefield, Mary

    2016-01-01

    Background:A 2011 nationwide school pandemic preparedness study found schools to be deficient. We examined the impact of a school nurse educational intervention aimed at improving K-12 school biological event preparedness. Mehods: Missouri Association of School Nurses (MASN) members were e-mailed a survey link in fall 2013 (ie, preintervention),…

  11. Factors Cultivating Sustainable Online Communities for K-12 Teacher Professional Development

    ERIC Educational Resources Information Center

    Hur, Jung Won; Hara, Noriko

    2007-01-01

    The purpose of this study is to discover factors related to fostering a sustainable online community for K-12 teachers. This study was conducted through the investigation of an online teacher community called INDISCHOOL in Korea. Data were gathered through in-depth telephone interviews with INDISCHOOL members, the examination of archived postings…

  12. Winona State University Anthology of K-12 Language Arts Action Research

    ERIC Educational Resources Information Center

    Sherman, Thomas F., Ed.; Lundquist, Margret, Ed.

    2004-01-01

    These papers are partial fulfillment of the requirements for the Master of Science Degree in Education at Winona State University in Winona, Minnesota. The cohort included a variety of licensure areas that represent most levels and content areas of K-12 education. The students were encouraged to keep their questions and hypothesis directed at…

  13. On Its Way to K-12 Classrooms, Web 2.0 Goes to Graduate School

    ERIC Educational Resources Information Center

    Norton, Priscilla; Hathaway, Dawn

    2008-01-01

    As corporate and higher education settings increasingly use Web 2.0 tools, the time has come to think about preparing K-12 in-service teachers to find ways in which these tools might support classroom teaching and learning goals. This article describes a graduate course designed and taught in spring 2007. Using a modeling and situated learning…

  14. The Effects of Learning in an Online Virtual Environment on K-12 Students

    ERIC Educational Resources Information Center

    Carnahan, Christopher D.

    2012-01-01

    Online learning has seen an explosive growth at the K-12 level, however little research has used an experimental design approach to specifically examine the outcomes of delivery methods. This study examines what effect learning in an immersive learning environment (virtual world) has on student achievement and satisfaction with the lesson. To…

  15. Unified Science Approach K-12, Proficiency Levels 13-21 and Semester Courses.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented is the third part of the K-12 unified science materials used in the public schools of Anne Arundel County, Maryland. Detailed descriptions are presented for the roles of students and teachers, purposes of bibliography, major concepts in unified science, processes of inquiry, scheme and model for scientific literacy, and program…

  16. Outstanding Science Trade Books for Students K-12: Books Published in 2015

    ERIC Educational Resources Information Center

    Science and Children, 2016

    2016-01-01

    Science teachers and mentors continue to be challenged to meet the high expectations of "A Framework for K-12 Science Education" and the "Next Generation Science Standards" ("NGSS"). Indeed the "Framework" urges to help learners "[build] progressively more sophisticated explanations of natural…

  17. How to Personalize Learning in K-12 Schools: Five Essential Design Features

    ERIC Educational Resources Information Center

    Lee, Dabae

    2014-01-01

    Personalized learning (PL) is spotlighted as a way to transform K-12 educational systems. PL customizes learning pace, instructional methods, and learning content to individual students. As much as PL sounds promising and complex, little guidance is available to educators and policymakers about how to effectively design PL. Five essential features…

  18. Accountability for Students in K-12 Online Learning: Perspectives from Michigan Stakeholders and Beyond

    ERIC Educational Resources Information Center

    Archambault, Leanna; Kennedy, Kathryn; Freidhoff, Joseph R.

    2016-01-01

    Policy surrounding K-12 online learning continues to evolve as the field grows exponentially. In Michigan, Section 21f of the State School Aid Act enacted in 2013 strengthened parents' and students' ability to request online courses: "A student enrolled in a district in any of grades 6 to 12 is eligible to enroll in an online course as…

  19. Virtual K-12 Learning: New Learning Frontiers for State Education Agencies

    ERIC Educational Resources Information Center

    Natale, Catherine Fisk; Cook, Janet

    2012-01-01

    This article explores the role of state education agencies in three states that have embarked on ambitious kindergarten through Grade 12 (K-12) virtual learning initiatives: Alabama, Florida, and Idaho. Subject to a rapidly changing environment influenced by factors beyond the jurisdiction of many state departments of education, the world of…

  20. South Carolina K-12 Online Schools: A Framework for Measuring Success in Teaching and Learning

    ERIC Educational Resources Information Center

    Stone, Carmen Mellisa Boatwright

    2013-01-01

    In the United States, K-12-12 online schools are growing, but research on the topic is limited. The purpose of this quantitative, correlational study was to determine if there was a relationship between teacher perceptions of the Effective Schools Correlates and student achievement within two South Carolina online high schools. The independent…

  1. Preparing for Online Teaching: Web-Based Assessment and Communication Skills in K12

    ERIC Educational Resources Information Center

    DeNisco, Alison

    2013-01-01

    Students are doing less hand-raising and more clicking as online classes become increasingly popular in K12 instruction, both in combination with brick-and-mortar classrooms and in independent full-time virtual schools. With online instruction comes a change in the nature of teaching, communicating with, and assessing students. As schools move to…

  2. Is K-12 Blended Learning Disruptive? An Introduction to the Theory of Hybrids

    ERIC Educational Resources Information Center

    Christensen, Clayton M.; Horn, Michael B.; Staker, Heather

    2013-01-01

    The Clayton Christensen Institute for Disruptive Innovation, formerly the Innosight Institute, has published three papers describing the rise of K-12 blended learning--that is, formal education programs that combine online learning and brick-and-mortar schools. This fourth paper is the first to analyze blended learning through the lens of…

  3. Assessing K-12 Teachers' Personal Environmental Education Teaching Efficacy and Outcome Expectancy

    ERIC Educational Resources Information Center

    Moseley, Christine; Huss, Jeanine; Utley, Juliana

    2010-01-01

    The purpose of this study was to determine change in environmental education teaching efficacy beliefs of K-12 teachers who participated in two weeks of an intensive summer earth systems science institute using the Global Learning and Observations to Benefit the Environment (GLOBE) curriculum as the conceptual framework. Thirty-eight teachers…

  4. Code to Learn: Where Does It Belong in the K-12 Curriculum?

    ERIC Educational Resources Information Center

    Moreno-León, Jesús; Robles, Gregorio; Román-González, Marcos

    2016-01-01

    The introduction of computer programming in K-12 has become mainstream in the last years, as countries around the world are making coding part of their curriculum. Nevertheless, there is a lack of empirical studies that investigate how learning to program at an early age affects other school subjects. In this regard, this paper compares three…

  5. A Teaching Guide and Experience Units K-12. Social Studies. Grade Five.

    ERIC Educational Resources Information Center

    Arapahoe County School District 6, Littleton, CO.

    The unit experiences for the K-12 curriculum guide, including these for grade 5, are outlined in SO 001 139. These units include the study of the culture, history, geography, and economics of regions of the United States. The depth study of Colorado draws relationship between the state, the nation, and the world. The emphasis for both grade 5 and…

  6. Alabama Course of Study: Humanities, K-12. Bulletin 1983, No. 16.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery.

    A scope and sequence for incorporating humanities into the existing K-12 curriculum contains 8 sections. Following an introduction, the first section outlines characteristics of an effective humanities program. The second and third sections contain teacher and student objectives for a humanities program, minimum requirements, and alternatives for…

  7. Battling Obesity in K-12 Learners from an Exercise Physiology Perspective

    ERIC Educational Resources Information Center

    Rattigan, Peter; Biren, Greg

    2007-01-01

    Physical education practitioners and programs have the opportunity and obligation to help children become physically educated, healthy, and active adults. This article discusses the battle against obesity in K-12 learners from an exercise physiology perspective and focuses on the fact that practitioners have all the tools they need to battle this…

  8. African Dance Aesthetics in a K-12 Dance Setting: From History to Social Justice

    ERIC Educational Resources Information Center

    Ward, Sheila A.

    2013-01-01

    This article invites the reader to gain a deeper understanding of the aesthetics of African-based dance through the elements of tradition, transformation, and social justice. A discussion of the aesthetics of African dances within Africa and throughout the African diaspora opens the doors to present these dances in a K-12 setting, to explore a…

  9. What Do K-12 Teachers Think about Including Student Surveys in Their Performance Ratings?

    ERIC Educational Resources Information Center

    Dretzke, Beverly J.; Sheldon, Timothy D.; Lim, Alicia

    2015-01-01

    This study investigated K-12 teachers' opinions about the use of student surveys as a component of a teacher evaluation system. Surveys were administered to teachers at the beginning of the school year and again in the spring. Analyses of teachers' responses on the fall survey indicated tentative support for the inclusion of student feedback in…

  10. Empowering K-12 Students with Disabilities to Learn Computational Thinking and Computer Programming

    ERIC Educational Resources Information Center

    Israel, Maya; Wherfel, Quentin M.; Pearson, Jamie; Shehab, Saadeddine; Tapia, Tanya

    2015-01-01

    This article's focus is on including computing and computational thinking in K-12 instruction within science, technology, engineering, and mathematics (STEM) education, and to provide that instruction in ways that promote access for students traditionally underrepresented in the STEM fields, such as students with disabilities. Providing computing…

  11. A Teaching Guide and Experience Units K-12. Social Studies. Grade Four.

    ERIC Educational Resources Information Center

    Arapahoe County School District 6, Littleton, CO.

    The unit experiences for the K-12 curriculum guide, including these for grade 4, are outlined in SO 001 139. These units initiate the study of geographic regions of the world. Emphasis in these area studies is placed on the regional topography, geographic factors, and people's economic, social, and cultural adjustment to their environment or…

  12. Policing in Schools: Developing a Governance Document for School Resource Officers in K-12 Schools

    ERIC Educational Resources Information Center

    Kim, Catherine Y.; Geronimo, India

    2010-01-01

    K-12 public schools across the country have begun to deploy law enforcement agents on school grounds in growing numbers. In 2004, 60% of high school teachers reported armed police officers stationed on school grounds, and in 2005, almost 70% of public school students ages 12 to 18 reported that police officers or security guards patrol their…

  13. K-12 Postsecondary Alignment and School Accountability: Investigating High School Responses to California's Early Assessment Program

    ERIC Educational Resources Information Center

    Jackson, Jacob; Kurlaender, Michal

    2016-01-01

    State K-12 assessments may soon include measures for college readiness, as California's already do. We seek to understand how California's Early Assessment Program (EAP, designed to assess high school juniors' college readiness in English and math) may have influenced overall school-level college readiness and state accountability outcomes. Using…

  14. Continuing the School Choice March: Policies to Promote Family K-12 Education Investment. Backgrounder. No. 2683

    ERIC Educational Resources Information Center

    Burke, Lindsey M.; Sheffield, Rachel

    2012-01-01

    Coverdell education savings accounts (ESAs), created through the federal tax code, allow families to save money tax-free for K-12 and higher education expenses. Lifting the cap on contributions to Coverdell accounts would provide greater access to school choice options by allowing families to invest more money in their children's education.…

  15. Teachers, Please Learn Our Names!: Racial Microagressions and the K-12 Classroom

    ERIC Educational Resources Information Center

    Kohli, Rita; Solorzano, Daniel G.

    2012-01-01

    Many Students of Color have encountered cultural disrespect within their K-12 education in regards to their names. While the racial undertones to the mispronouncing of names in schools are often understated, when analyzed within a context of historical and current day racism, the authors argue that these incidents are racial…

  16. Super Searchers Go to School: Sharing Online Strategies with K-12 Students, Teachers, and Librarians

    ERIC Educational Resources Information Center

    Valenza, Joyce Kasman

    2005-01-01

    Twelve prominent K-12 educators and educator librarians share their techniques and tips for helping students become effective, life-long information users. Through a series of skillful interviews, Joyce Kasman Valenza--techlife@school columnist for the "Philadelphia Inquirer" and herself a tech-savvy high school librarian--gets the experts to…

  17. Job Satisfaction, Organizational Commitment, and Turnover Intention of Online Teachers in the K-12 Setting

    ERIC Educational Resources Information Center

    Larkin, Ingle M.; Brantley-Dias, Laurie; Lokey-Vega, Anissa

    2016-01-01

    The purpose of this study was to measure and explore factors influencing K-12 online teachers' job satisfaction, organizational commitment, and turnover intentions. Using Maslow's Hierarchy of Needs (1954), Herzberg's Two-Factor Theory of Satisfaction (1959, 1968), Meyer and Allen's measure of Organizational Commitment (1997), and Fishbein and…

  18. Survey of K-12 Science Teachers' Educational Product Needs from Planetary Scientists

    ERIC Educational Resources Information Center

    Slater, Stephanie J.; Slater, Timothy F.; Olsen, Julia K.

    2009-01-01

    Most education reform documents of the last two decades call for students to have authentic science inquiry experiences that mimic scientific research using real scientific data. In order for professional planetary scientists to provide the most useful data and professional development for K-12 teachers in support of science education reform, an…

  19. (Re)Defining the Filipino: Notions of Citizenship in the New K+12 Curriculum

    ERIC Educational Resources Information Center

    de los Reyes, Elizer Jay

    2013-01-01

    In June 2012, the Philippine government implemented what it called the K+12 Curriculum which reformed its basic education system by adding two more years of schooling to the then existing 10-year structure. Complicated by the long experience and participation of the Filipinos in the diaspora, the constantly lingering thought of leaving for greener…

  20. Arts Education K-12: Teacher Handbook. North Carolina Competency-Based Curriculum Subject-by-Subject.

    ERIC Educational Resources Information Center

    Chapman, Barbara Holland

    The North Carolina arts education curriculum encompasses K-12 programs in dance, folk arts, music, theater arts, and visual arts. It is designed to provide a scope and sequence which encourages students to develop the essential senses of sight, hearing, smell, taste, touch, and kinetic awareness. It provides opportunities to develop thinking…

  1. The Preparation of Teacher Candidates for K-12 Online Learning Environments: A Case Study

    ERIC Educational Resources Information Center

    Williams, Nicole V.

    2015-01-01

    The purpose of this study was to determine how teacher education programs may better prepare teacher candidates to teach in K-12 online learning environments. The primary research question addressed was: What specific knowledge, skills, and dispositions should teacher education programs include in their curriculum to better prepare teacher…

  2. Integrating Emerging Technologies in Teaching Ugandan Traditional Dances in K-12 Schools in New York City

    ERIC Educational Resources Information Center

    Mabingo, Alfdaniels

    2015-01-01

    Schools in New York City have made attempts to embrace and support the strand of "making connections", which is laid out in the New York City Department of Dance blueprint for teaching and learning in dance for grades PreK-12. Accordingly, some schools have integrated Ugandan traditional dances into the dance curriculum, and dance…

  3. Health Education Teacher Resource Handbook: A Practical Guide for K-12 Health Education.

    ERIC Educational Resources Information Center

    Mahoney, Beverly Saxton, Ed.; Olsen, Larry K., Ed.

    This handbook provides background information on the health curriculum, as well as current, comprehensive information on publications, standards, and special materials for K-12 health education. The manual begins with an introduction, by P. Bruce Uhrmacher, which provides an overview of the ideologies and philosophies that have affected curriculum…

  4. Thinking outside the Box: Placing Park and Recreation Professionals in K-12 Schools

    ERIC Educational Resources Information Center

    Dustin, Daniel; Hibbler, Dan; McKenney, Alexis; Blitzer, Laura

    2004-01-01

    The authors argue that it is time to place park and recreation professionals in K-12 schools on a permanent basis. Their proposal is based on the following observations: (1) school facilities are grossly underutilized; (2) the majority of a child's life takes place outside the classroom; (3) park and recreation programs are effective "hooks" for…

  5. K-12 Single-Sex Education: What Does the Research Say? ERIC Digest.

    ERIC Educational Resources Information Center

    Haag, Pamela

    Although research on the effects of K-12 single-sex education is inconclusive in general, some common themes emerge in the research literature. This Digest reviews that research with particular attention to effects on girls' attitudes and achievement. The Digest first discusses attitudinal variables (i.e., self-esteem and attitudes toward academic…

  6. A Nonverbal Language for Imagining and Learning: Dance Education in K-12 Curriculum

    ERIC Educational Resources Information Center

    Hanna, Judith Lynne

    2008-01-01

    Curriculum theorists have provided a knowledge base concerning aesthetics, agency, creativity, lived experience, transcendence, learning through the body, and the power of the arts to engender visions of alternative possibilities in culture, politics, and the environment. However, these theoretical threads do not reveal the potential of K-12 dance…

  7. Teachers' Perceptions of K-12 Online: Impacting the Design of a Graduate Course Curriculum

    ERIC Educational Resources Information Center

    Barbour, Michael K.; Harrison, Kelly Unger

    2016-01-01

    While K-12 online learning in the United States has increased exponentially, the ability of teacher education programs to adequately prepare teachers to design, deliver, and support has been deficient. A small number of universities have begun to address this deficit through the introduction of graduate certificates in online teaching. This…

  8. Impact of Adopt-a-Classroom Partnerships between K-12 and University Faculty

    ERIC Educational Resources Information Center

    Smith, Elizabeth; Kindall, Heather D.; Carter, Vinson; Beachner, Maggie

    2016-01-01

    There is often a disconnect between K-12 schools and postsecondary institutions. While this gap has grown consistently, the need for collaboration between systems is greater than ever. The Adopt-A-Classroom program was created to address the need for greater university faculty involvement in public schools by providing opportunities for…

  9. Framework for the Social Studies in Wyoming, Grades K-12. A Guide for Curriculum Development.

    ERIC Educational Resources Information Center

    Wyoming State Dept. of Education, Cheyenne.

    GRADES OR AGES: K-12. SUBJECT MATTER: Social studies. ORGANIZATION AND PHYSICAL APPEARANCE: The introductory material includes sections on curriculum improvement, new social studies, and scope and sequence. A suggested conceptual framework for the program is presented in the form of a chart, with columns for history, anthropology-sociology,…

  10. Urban K12 School-University Teacher Preparation Partnerships: An Initiative of the Great Cities' Universities

    ERIC Educational Resources Information Center

    Ilmer, Steven; Kirby, Peggy C.

    2007-01-01

    The 21 urban research universities that are members of the Great Cities' Universities (GCU) annually enroll approximately 20 percent of the students in the United States who are preparing to teach in K12 urban schools. This study examined the experiences of GCU-sponsored, school-university teacher preparation partnerships in Atlanta, Houston,…

  11. Teaching K-12 teachers and students about nanoscale science through microscopy

    NASA Astrophysics Data System (ADS)

    Healy, Nancy

    2014-09-01

    The National Nanotechnology Infrastructure Network (NNIN) is an integrated partnership of 14 universities across the US funded by NSF to support nanoscale researchers. NNIN's education and outreach programs are large and varied and includes outreach to the K-12 community in the form of professional development workshops and school programs. Two important components of nanoscale science education are understanding size and scale and the tools used in nanoscale science and engineering (NSE). As part of our K-12 endeavors, we educate K-12 students and teachers about the tools of nanoscience by providing experiences with the Hitachi TM 3000 tabletop Scanning Electron Microscope (SEM). There are three of these across the network that are used in education and outreach. This paper will discuss approaches we use to engage the K-12 community at NNIN's site at Georgia Institute of Technology to understand size and scale and the applications of a variety of microscopes to demonstrate the imaging capabilities of these to see both the micro and nano scales. We not only use the tabletop SEM but also include USB digital microscopes, a Keyence VHX- 600 Digital Microscope, and even a small lens used with smart phones. The goal of this outreach is to educate students as well as teachers about the capabilities of the various instruments and their importance at different size scales.

  12. Natural Science of the Lewis and Clark Expedition: Activities for Grades K-12.

    ERIC Educational Resources Information Center

    Eid, Nancy; Elvidge, Janice; Osborn, JoAnn; Minard, Barbara

    2003-01-01

    Describes activities for K-12 students, most of which are adapted from "The Lewis and Clark Expedition: Scientific Discovery Educator's Resource Guide" created by the partnership of Fort Clatsop National Memorial and the U.S. Fish and Wildlife Service. (Author/KHR)

  13. Recounting the K-12 School Experiences of Adults Who Stutter: A Qualitative Analysis

    ERIC Educational Resources Information Center

    Daniels, Derek E.; Gabel, Rodney M.; Hughes, Stephanie

    2012-01-01

    This study qualitatively explored the primary and secondary (K-12) school experiences of adults who stutter. The primary investigator conducted semi-structured interviews with 11 participants, a first focus group interview with 6 participants, and a second focus group interview with 4 participants. Participants discussed the various ways in which…

  14. A Field Study of Telepractice for School Intervention Using the ASHA NOMS K-12 Database

    ERIC Educational Resources Information Center

    Gabel, Rodney; Grogan-Johnson, Sue; Alvares, Robin; Bechstein, Leah; Taylor, Jacquelyn

    2013-01-01

    The purpose of this article is to describe the characteristics and effectiveness of a telepractice speech-language therapy program for school-age children. Outcome data related to the caseload, type and amount of intervention, and student progress from a school-based telepractice therapy program were compared with the K-12 Schools National…

  15. One-to-One Laptops in K-12 Classrooms: Voices of Students

    ERIC Educational Resources Information Center

    Zheng, Binbin; Arada, Kathleen; Niiya, Melissa; Warschauer, Mark

    2014-01-01

    In planning educational technology initiatives, the concerns of many stakeholders are typically taken into account, including the concerns of administrators, teachers, parents, and employers. The perspective of students are recognized as valuable, but not often queried or considered. This paper explores the opinions of K-12 students about a…

  16. Qatar's K-12 Education Reform Has Achieved Success in Its Early Years. Research Brief

    ERIC Educational Resources Information Center

    Larson, Judy

    2009-01-01

    To evaluate progress made in the first years of Qatar's implementation of K-12 education reform, RAND analyzed data from school-level observations, national surveys, and national student assessments. The study found that students in the new, Independent schools were performing better than those in Ministry schools, and there was greater student…

  17. The USDA and K-12 Partnership: A Model Program for Federal Agencies

    ERIC Educational Resources Information Center

    Scott, Timothy P.; Wilson, Craig; Upchurch, Dan R.; Goldberg, Maria; Bentz, Adrienne

    2011-01-01

    The Future Scientists Program of Texas A&M University and the Agricultural Research Service branch of USDA serves as a model program of effective collaboration between a federal agency and K-12. It demonstrates true partnership that contextualizes learning of science and provides quality professional development, benefiting teachers and their…

  18. Teaching Online across State Lines. Keeping Pace with K-12 Digital Learning. Policy Brief

    ERIC Educational Resources Information Center

    Watson, John; Murin, Amy; Pape, Larry

    2014-01-01

    Among the ways in which states attempt to ensure quality in K-12 education is by requiring that most teachers in public schools be licensed via state-level requirements that vary by state. This patchwork of requirements has not been a problem for most teachers over the last century, because so few teachers taught in multiple states concurrently.…

  19. Family Assessment in K-12 Settings: Understanding Family Systems to Provide Effective, Collaborative Services

    ERIC Educational Resources Information Center

    Eppler, Christie; Weir, Sarah

    2009-01-01

    Professional school counselors, school psychologists, and other professionals working in K-12 settings have a complex job of meeting the needs of all students. Often, referral to outside counseling is necessary; however, an effective and comprehensive counseling model advocates for school mental health professionals to employ a wide variety of…

  20. Identifying and Reconstructing Common Cold Misconceptions among Developing K-12 Educators

    ERIC Educational Resources Information Center

    Johnson, Marcus Lee; Bungum, Timothy

    2013-01-01

    Background: Common cold misconceptions may contribute to ill-informed decisions and recommendations made by K-12 educators who often encounter infected students. Understanding the structure of educators' misconceptions can be used to improve health instruction in teacher professional preparation programs. Purpose: The purposes of this project were…