Sarris, Jerome; Teschke, Rolf; Stough, Con; Scholey, Andrew; Schweitzer, Isaac
Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such as leaves or bark); thus both the plant chemotype and the plant part used may be critical factors. If re-institution of kava in the EU is to occur, more evidence is required to determine its safety and efficacy. Furthermore, according to current evidence, the study of traditional water soluble rhizome extracts using a noble cultivar of kava may be advised. The Kava Anxiety-Lowering Medication (KALM) project is due to start in late 2010 to address these considerations. The KALM project uses an aqueous rhizome extract of a noble cultivar of kava in participants with generalised anxiety and Generalised Anxiety Disorder (GAD). The project comprises of 1) an acute RCT, kava (180 mg of kavalactones) versus oxazepam and placebo in 20 anxious people, testing effects on cognition, mood, anxiety, and driving; 2) an 8-week RCT comparing kava (120 mg kavalactones) versus placebo in 100 patients with GAD. To assess differences between dosages, non-responders at 3 weeks will be titrated to 240 mg of kavalactones. The project will also assess the effects of kava on liver function tests and its side effects profile. A novel component of the project is the pharmacogenomic exploration of phenotypical responses (GABA system and cytochrome P450 markers). The results of the study may be of benefit to sufferers of anxiety and the future economy of the Pacific islands, potentially providing an important step in the way forward with kava.
Kalvans, Andis; Hang, Tiit
solely by the basin depth and duration of the ice cover period. A normal grading is observed in most of the studied winter layers of individual varves. Relatively large errors in the estimated terminal grain size permits only to conclude that it is in line with previously reconstructed water depth constrained by the maximum possible duration of the lake ice cover. The research is supported by the European Union through the ESF Mobilitas grant No MJD309. References Hang, T., Kohv, M. 2013. Glacial varves at Pärnu, south-western Estonia: a local varve chronology and proglacial sedimentary environment. GFF, June, 37-41. doi:10.1080/11035897.2013.775598 Rosentau, A., Vassiljev, J., Hang, T., Saarse, L., Kalm, V. 2009. Development of the Baltic Ice Lake in the eastern Baltic. Quaternary International, 206(1-2), 16-23. doi:10.1016/j.quaint.2008.10.005