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Sample records for kaldaru diana eerma

  1. Making a Way for Diana.

    ERIC Educational Resources Information Center

    Shima, Kate; Gsovski, Barbara K.

    1996-01-01

    Although many parents and educators hesitate to involve children in a regular course of drug therapy, Ritalin often proves beneficial to Attention Deficit Disorder sufferers. Diana, an intelligent, easily distracted middle schooler, was helped by a team approach using evaluation, remediation, behavioral therapy, medication, and a supportive…

  2. Diana Leonard and Materialist Feminism

    ERIC Educational Resources Information Center

    Jackson, Stevi

    2013-01-01

    This tribute to Diana Leonard focuses on her contribution to materialist feminism, both through bringing the work of key French theorists to the attention of an Anglophone audience and through her own sociological work on the family, marriage and childhood. In so doing it draws attention to the importance of her work as editor and…

  3. Social familiarity affects Diana monkey (Cercopithecus diana diana) alarm call responses in habitat-specific ways.

    PubMed

    Stephan, Claudia; Zuberbühler, Klaus

    2016-02-01

    Male Diana monkeys produce loud and acoustically distinct alarm calls to leopards and eagles that propagate over long distances, much beyond the immediate group. Calling is often contagious, with neighbouring males responding to each other's calls, indicating that harem males communicate both to local group members and distant competitors. Here, we tested whether male Diana monkeys responding to each other's alarm calls discriminated familiar from unfamiliar callers in two populations in Taï Forest (Ivory Coast) and on Tiwai Island (Sierra Leone). At both sites, we found specific acoustic markers in male alarm call responses that discriminated familiar from unfamiliar callers, but response patterns were site-specific. On Tiwai Island, males responded to familiar males' eagle alarms with 'standard' eagle alarm calls, whereas unfamiliar males triggered acoustically atypical eagle alarms. The opposite was found in Taï Forest where males responded to unfamiliar males' eagle alarm calls with 'standard' eagle alarms, and with atypical eagle alarms to familiar males' calls. Moreover, only Taï, but not Tiwai, males also marked familiarity with the caller in their leopard-induced alarms. We concluded that male Diana monkeys encode not only predator type but also signaller familiarity in their alarm calls, although in population-specific ways. We explain these inter-site differences in vocal behaviour in terms of differences in predation pressure and population density. We discuss the adaptive function and implications of this behaviour for the origins of acoustic flexibility in primate communication. PMID:26998336

  4. Social familiarity affects Diana monkey (Cercopithecus diana diana) alarm call responses in habitat-specific ways

    PubMed Central

    Stephan, Claudia; Zuberbühler, Klaus

    2016-01-01

    Male Diana monkeys produce loud and acoustically distinct alarm calls to leopards and eagles that propagate over long distances, much beyond the immediate group. Calling is often contagious, with neighbouring males responding to each other’s calls, indicating that harem males communicate both to local group members and distant competitors. Here, we tested whether male Diana monkeys responding to each other’s alarm calls discriminated familiar from unfamiliar callers in two populations in Taï Forest (Ivory Coast) and on Tiwai Island (Sierra Leone). At both sites, we found specific acoustic markers in male alarm call responses that discriminated familiar from unfamiliar callers, but response patterns were site-specific. On Tiwai Island, males responded to familiar males’ eagle alarms with ‘standard’ eagle alarm calls, whereas unfamiliar males triggered acoustically atypical eagle alarms. The opposite was found in Taï Forest where males responded to unfamiliar males’ eagle alarm calls with ‘standard’ eagle alarms, and with atypical eagle alarms to familiar males’ calls. Moreover, only Taï, but not Tiwai, males also marked familiarity with the caller in their leopard-induced alarms. We concluded that male Diana monkeys encode not only predator type but also signaller familiarity in their alarm calls, although in population-specific ways. We explain these inter-site differences in vocal behaviour in terms of differences in predation pressure and population density. We discuss the adaptive function and implications of this behaviour for the origins of acoustic flexibility in primate communication. PMID:26998336

  5. Diana Al-Hadid: Identity and Heritage

    ERIC Educational Resources Information Center

    Jungerberg, Tom; Smith, Anna; Borsh, Colleen

    2012-01-01

    Diana Al-Hadid's sculptures reflect the many locations, cultures, histories, and mythologies that have shaped her as an artist. In large-scale works which have the appearance of architectural ruins, Al-Hadid employs imagery drawn from many diverse interests including science and technology, history, and literature. She also incorporates images and…

  6. DIANA-TarBase and DIANA Suite Tools: Studying Experimentally Supported microRNA Targets.

    PubMed

    Paraskevopoulou, Maria D; Vlachos, Ioannis S; Hatzigeorgiou, Artemis G

    2016-01-01

    microRNAs (miRNAs) are short non-coding RNAs (∼22 nts) present in animals, plants, and viruses. They are considered central post-transcriptional regulators of gene expression and are key components in a great number of physiological and pathological conditions. The accurate characterization of their targets is considered essential to a series of applications and basic or applied research settings. DIANA-TarBase (http://www.microrna.gr/tarbase) was initially launched in 2006. It is a reference repository indexing experimentally derived miRNA-gene interactions in different cell types, tissues, and conditions across numerous species. This unit focuses on the study of experimentally supported miRNA-gene interactions, as well as their functional interpretation through the use of available tools in the DIANA suite (http://www.microrna.gr). The proposed use-case scenarios are presented in protocols, describing how to utilize the DIANA-TarBase database and DIANA-microT-CDS server and perform miRNA-targeted pathway analysis with DIANA-miRPath-v3. All analyses are directly invoked or initiated from DIANA-TarBase. © 2016 by John Wiley & Sons, Inc. PMID:27603020

  7. DIANA NaI-Detector Energy Calibration

    NASA Astrophysics Data System (ADS)

    O'Connor, Kyle; Elofson, David; Lewis, Codie; O'Brien, Erin; Buggelli, Kelsey; Miller, Nevin; O'Rielly, Grant; Maxtagg Collaboration

    2014-09-01

    The DIANA detector is being used for measurements of near threshold pion photoproduction and high-energy nuclear Compton scattering being performed at the MAX-lab tagged photon facility in Lund, Sweden. Accurate energy calibrations are essential for determining the final results from both of these experiments. An energy calibration has been performed for DIANA, a single-crystal, large-volume, NaI detector. This calibration was made by placing the detector directly in the tagged photon beam with energies from 145 to 165 MeV and fitting the detector response to the known photon energies. The DIANA crystal is instrumented with 19 PMTs, pedestal corrections were applied and the PMTs were gain matched in order to combine the readout value from each PMT and determine the final detector response. This response was fitted to the tagged photon energies to provide the final energy calibration. The calibrations were performed with two triggers; one from the detector itself and one provided by the photon tagger. The quality of the final calibration fit and the energy resolution of the detector, σ ~ 2 . 4 MeV, will be shown.

  8. Pulse register phonation in Diana monkey alarm calls

    NASA Astrophysics Data System (ADS)

    Riede, Tobias; Zuberbühler, Klaus

    2003-05-01

    The adult male Diana monkeys (Cercopithecus diana) produce predator-specific alarm calls in response to two of their predators, the crowned eagles and the leopards. The acoustic structure of these alarm calls is remarkable for a number of theoretical and empirical reasons. First, although pulsed phonation has been described in a variety of mammalian vocalizations, very little is known about the underlying production mechanism. Second, Diana monkey alarm calls are based almost exclusively on this vocal production mechanism to an extent that has never been documented in mammalian vocal behavior. Finally, the Diana monkeys' pulsed phonation strongly resembles the pulse register in human speech, where fundamental frequency is mainly controlled by subglottal pressure. Here, we report the results of a detailed acoustic analysis to investigate the production mechanism of Diana monkey alarm calls. Within calls, we found a positive correlation between the fundamental frequency and the pulse amplitude, suggesting that both humans and monkeys control fundamental frequency by subglottal pressure. While in humans pulsed phonation is usually considered pathological or artificial, male Diana monkeys rely exclusively on pulsed phonation, suggesting a functional adaptation. Moreover, we were unable to document any nonlinear phenomena, despite the fact that they occur frequently in the vocal repertoire of humans and nonhumans, further suggesting that the very robust Diana monkey pulse production mechanism has evolved for a particular functional purpose. We discuss the implications of these findings for the structural evolution of Diana monkey alarm calls and suggest that the restricted variability in fundamental frequency and robustness of the source signal gave rise to the formant patterns observed in Diana monkey alarm calls, used to convey predator information.

  9. Pulse register phonation in Diana monkey alarm calls.

    PubMed

    Riede, Tobias; Zuberbühler, Klaus

    2003-05-01

    The adult male Diana monkeys (Cercopithecus diana) produce predator-specific alarm calls in response to two of their predators, the crowned eagles and the leopards. The acoustic structure of these alarm calls is remarkable for a number of theoretical and empirical reasons. First, although pulsed phonation has been described in a variety of mammalian vocalizations, very little is known about the underlying production mechanism. Second, Diana monkey alarm calls are based almost exclusively on this vocal production mechanism to an extent that has never been documented in mammalian vocal behavior. Finally, the Diana monkeys' pulsed phonation strongly resembles the pulse register in human speech, where fundamental frequency is mainly controlled by subglottal pressure. Here, we report the results of a detailed acoustic analysis to investigate the production mechanism of Diana monkey alarm calls. Within calls, we found a positive correlation between the fundamental frequency and the pulse amplitude, suggesting that both humans and monkeys control fundamental frequency by subglottal pressure. While in humans pulsed phonation is usually considered pathological or artificial, male Diana monkeys rely exclusively on pulsed phonation, suggesting a functional adaptation. Moreover, we were unable to document any nonlinear phenomena, despite the fact that they occur frequently in the vocal repertoire of humans and nonhumans, further suggesting that the very robust Diana monkey pulse production mechanism has evolved for a particular functional purpose. We discuss the implications of these findings for the structural evolution of Diana monkey alarm calls and suggest that the restricted variability in fundamental frequency and robustness of the source signal gave rise to the formant patterns observed in Diana monkey alarm calls, used to convey predator information.

  10. A Hypoderma diana (Diptera: Hypodermatidae) infection in a horse.

    PubMed

    Hendrikx, W M; Jansen, J; de Vries, T J

    1989-01-01

    An infection with second-stage larvae of the warble-fly H. diana in a horse is described. The second-stage larvae were incapable of developing into the third stage, because horses are unsuitable hosts and because the infected horse was treated with an insecticide. Since the horse was used for dragging trees in the forests, the infection was likely contracted via contact with H. diana, a normal parasite of roe deer in the Netherlands. PMID:2718349

  11. DIANA - A deep underground accelerator for nuclear astrophysics experiments

    NASA Astrophysics Data System (ADS)

    Winklehner, Daniel; Lemut, Alberto; Leitner, Daniela; Couder, Manoel; Hodgkinson, Adrian; Wiescher, Michael

    2013-04-01

    DIANA (Dakota Ion Accelerator for Nuclear Astrophysics) is a proposed facility designed to be operated deep underground. The DIANA collaboration includes nuclear astrophysics groups from Lawrence Berkeley National Laboratory, Michigan State University, Western Michigan University, Colorado School of Mines, and the University of North Carolina, and is led by the University of Notre Dame. The scientific goals of the facility are measurements of low energy nuclear cross-sections associated with sun and pre-supernova stars in a laboratory setup at energies that are close to those in stars. Because of the low stellar temperatures associated with these environments, and the high Coulomb barrier, the reaction cross-sections are extremely low. Therefore these measurements are hampered by small signal to background ratios. By going underground the background due to cosmic rays can be reduced by several orders of magnitude. We report on the design status of the DIANA facility with focus on the 3 MV electrostatic accelerator.

  12. DIANA - A deep underground accelerator for nuclear astrophysics experiments

    SciTech Connect

    Winklehner, Daniel; Leitner, Daniela; Lemut, Alberto; Hodgkinson, Adrian; Couder, Manoel; Wiescher, Michael

    2013-04-19

    DIANA (Dakota Ion Accelerator for Nuclear Astrophysics) is a proposed facility designed to be operated deep underground. The DIANA collaboration includes nuclear astrophysics groups from Lawrence Berkeley National Laboratory, Michigan State University, Western Michigan University, Colorado School of Mines, and the University of North Carolina, and is led by the University of Notre Dame. The scientific goals of the facility are measurements of low energy nuclear cross-sections associated with sun and pre-supernova stars in a laboratory setup at energies that are close to those in stars. Because of the low stellar temperatures associated with these environments, and the high Coulomb barrier, the reaction cross-sections are extremely low. Therefore these measurements are hampered by small signal to background ratios. By going underground the background due to cosmic rays can be reduced by several orders of magnitude. We report on the design status of the DIANA facility with focus on the 3 MV electrostatic accelerator.

  13. Data analysis with the DIANA meta-scheduling approach

    NASA Astrophysics Data System (ADS)

    Anjum, A.; McClatchey, R.; Willers, I.

    2008-07-01

    The concepts, design and evaluation of the Data Intensive and Network Aware (DIANA) meta-scheduling approach for solving the challenges of data analysis being faced by CERN experiments are discussed in this paper. Our results suggest that data analysis can be made robust by employing fault tolerant and decentralized meta-scheduling algorithms supported in our DIANA meta-scheduler. The DIANA meta-scheduler supports data intensive bulk scheduling, is network aware and follows a policy centric meta-scheduling. In this paper, we demonstrate that a decentralized and dynamic meta-scheduling approach is an effective strategy to cope with increasing numbers of users, jobs and datasets. We present 'quality of service' related statistics for physics analysis through the application of a policy centric fair-share scheduling model. The DIANA meta-schedulers create a peer-to-peer hierarchy of schedulers to accomplish resource management that changes with evolving loads and is dynamic and adapts to the volatile nature of the resources.

  14. DIANA - An Underground Accelerator Facility for Nuclear Astrophysics

    NASA Astrophysics Data System (ADS)

    Champagne, Arthur

    2011-10-01

    Measuring nuclear reactions of astrophysical interest at stellar energies is usually a daunting task because the cross sections are very small and background rates can be comparatively large. Often, cosmic-ray interactions set the limit on experimental sensitivity, but can be reduced to an insignificant level by placing an accelerator underground -- as has been demonstrated by the LUNA accelerators in the Gran Sasso underground laboratory. The Dual Ion Accelerator facility for Nuclear Astrophysics (DIANA) is a proposed next-generation underground accelerator facility, which would be constructed at the 4850 ft level of the Homestake Mine in Lead, SD. This talk will describe DIANA and the questions in nuclear astrophysics that can be explored at such a laboratory.

  15. Process Waste Assessment for the Diana Laser Laboratory

    SciTech Connect

    Phillips, N.M.

    1993-12-01

    This Process Waste Assessment was conducted to evaluate the Diana Laser Laboratory, located in the Combustion Research Facility. It documents the hazardous chemical waste streams generated by the laser process and establishes a baseline for future waste minimization efforts. This Process Waste Assessment will be reevaluated in approximately 18 to 24 months, after enough time has passed to implement recommendations and to compare results with the baseline established in this assessment.

  16. IDENTIFICATION OF MYCOBACTERIUM GENAVENSE IN A DIANA MONKEY (CERCOPITHECUS DIANA) BY POLYMERASE CHAIN REACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.

    PubMed

    Kelly, Kathleen M; Wack, Allison N; Bradway, Dan; Simons, Brian W; Bronson, Ellen; Osterhout, Gerard; Parrish, Nicole M; Montali, Richard J

    2015-06-01

    A 25-yr-old Diana monkey (Cercopithecus diana) with a 1.5-yr history of chronic colitis and diarrhea was found to have disseminated granulomatous disease with intralesional acid fast bacilli. Bacilli were identified as Mycobacterium genavense by polymerase chain reaction, sequencing of the 16S-23S ribosomal RNA intergenic spacer (ITS) gene, and mycolic acid analysis by high-performance liquid chromatography. Mycobacterium genavense is a common cause of mycobacteriosis in free-ranging and captive birds. In addition, recognition of opportunistic infection in human immunodeficiency virus-positive patients is increasing. Disease manifestations of M. genavense are similar to Mycobacterium avium complex (MAC) and include fever, wasting, and diarrhea with disseminated disease. Similar clinical signs and lesions were observed in this monkey. Mycobacterium genavense should be considered as a differential for disseminated mycobacterial disease in nonhuman primates as this agent can mimic MAC and related mycobacteria.

  17. Tamarugite from Diana Cave (SW Romania) -first true karst occurrence

    NASA Astrophysics Data System (ADS)

    Pušcaš, C. M.; Onac, B. P.; Effenberger, H. S.; Povarǎ, I.

    2012-04-01

    Diana Cave is located within the town limits of Baile Herculane (SW Romania) and develops as a 14 m long, westward oriented, unique passage guided by the Diana fault [1]. At the far end of the cave, the thermo-mineral Diana Spring wells forth. In the early 1970s a mine gallery that intersected the cave was created to drain the water into a pumping station and the original cave passage was somewhat altered and reinforced with concrete. Today the concrete and the silty limestone cave walls are heavily corroded by H2SO4 outgassing from the hot water (ca. 50°C) and display abundant gypsum crusts, soggy aggregates of native S, and a variety of more exotic sulfates. Among them, a mineral that has been previously identified in caves only in connection to volcanic activity, either as thermal springs or fumaroles [2]: tamarugite [NaAl(SO4)26H2O]. It was [3] that first mentioned the occurrence of this Na and Al sulfate in Diana Cave, our research aiming to give a detailed description of this mineral, its paragenesis, and mechanisms of precipitation. Recently, tamarugite has also been identified in a sulfuric acid cave from Greece [4]. Along with powder X-ray diffractions coupled with Rietveld refinement, scanning electron microscope, and electron probe micro-analysis, δ18O and δ34S compositions of the sulfate mineral as well as precipitates from the water were analyzed to identify and better constrain the genesis of this rare sulfate. Regrettably, the crystal size of our specimens is inappropriate for identification by means of single crystal X-ray diffraction. Physical and chemical parameters of Diana Spring were as well measured on several occasions. Geochemical analysis suggests that the minute, white tamarugite flakes precipitated in Diana Cave as a result of the interactions between the thermo-mineral water or water vapor and the original limestone bedrock and concrete that blankets the mine gallery. [1] Povara, I., Diaconu, G., Goran, C. (1972). Observations pr

  18. Underground Accelerators for Precise Nuclear Physics: LUNA and DIANA

    NASA Astrophysics Data System (ADS)

    Leitner, Daniela

    2011-05-01

    Current stellar model simulations are at a level of precision that uncertainties in the nuclear-reaction rates are becoming significant for theoretical predictions and for the analysis of observational signatures. To address several open questions in cosmology, astrophysics, and non-Standard-Model neutrino physics, new high precision measurements of direct-capture nuclear fusion cross sections will be essential. At these low energies, fusion cross sections decrease exponentially with energy and are expected to approach femtobarn levels or less. The experimental difficulties in determining the low-energy cross sections are caused by large background rates associated with cosmic ray-induced reactions, background from natural radioactivity in the laboratory environment, and the beam-induced background on target impurities. Natural background can be reduced by careful shielding of the target and detector environment, and beam-induced background can be reduced by active shielding techniques through event identification, but it is difficult to reduce the background component from cosmic ray muons. An underground location has the advantage that the cosmic ray-induced background is reduced by several orders of magnitude, allowing the measurements to be pushed to far lower energies than feasible above ground. This has been clearly demonstrated at LUNA by the successful studies of critical reactions in the pp-chains and first reaction studies in the CNO cycles. The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, Michigan State University, Colorado School of Mines, Regis University, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory, to build a nuclear astrophysics accelerator facility deep underground. The DIANA accelerator facility is being designed to achieve large laboratory reaction rates by delivering two orders of magnitude higher ion beams to a

  19. Geologic Map of the Diana Chasma Quadrangle (V-37), Venus

    USGS Publications Warehouse

    Hansen, V.L.; DeShon, H.R.

    2002-01-01

    Diana Chasma quadrangle hosts some of the steepest topography on Venus. Altimetry measurements range from -2.5 to 4.7 km (0.0 = mean planetary radius), with a surface mean of 0.6 km. Fractures and faults within the central fracture/rift zone create large blocks of down-dropped material, especially along the east-central edge of the map area. The Dali and Diana chasmata display slopes of >30°, the steepest and deepest trenches on Venus. Both chasmata host landslide deposits presumably sourced from the steep chasmata walls. The tessera inlier, coronae, and ridge belts sit topographically above Rusalka and Zhibek planitiae. Rusalka Planitia topography describes broad undulations having northwest-trending ridges spaced ~200 km apart. The most distinctive ridge, Vetsorgo Dorsum, centered at 6.5° S., 163° E., is a Class I ridge belt owing to its simple arch morphology. The central interior of Markham crater sits topographically lower than the surrounding region, which slopes downward to the east.

  20. DIANA: nuclear astrophysics with a deep underground accelerator facility

    NASA Astrophysics Data System (ADS)

    Lemut, Alberto

    2013-10-01

    Current stellar model simulations are at a level of precision such that nuclear reaction rates represent a major source of uncertainty for theoretical predictions and for the analysis of observational signatures. To address several open questions in cosmology, astrophysics, and non-Standard-Model neutrino physics, new high precision measurements of direct-capture nuclear fusion cross sections are essential. Experimental studies of nuclear reaction of astrophysical interest are hampered by the exponential drop of the cross-section. The extremely low value of σ (E) within the Gamow peak prevents measurement in a laboratory at the earth surface. The signal to noise ratio would be too small, even with the highest beam intensities presently available from industrial accelerators, because of the cosmic ray interactions with the detectors and surrounding materials. An excellent solution is to install an accelerator facility deep underground where the cosmic rays background into detectors is reduced by several order of magnitude, allowing the measurements to be pushed to far lower energies than presently possible. This has been clearly demonstrated at the Laboratory for Underground Nuclear Astrophysics (LUNA) by the successful studies of critical reactions in the pp-chains and first reaction studies in the CNO cycles. However many critical reactions still need high precision measurements, and next generation facilities, capable of very high beam currents over a wide energy range and state of the art target and detection technology, are highly desirable. The DIANA accelerator facility is being designed to achieve large laboratory reaction rates by delivering high ion beam currents (up to 100 mA) to a high density (up to 1018 atoms/cm2), super-sonic jet-gas target as well as to a solid target. DIANA will consist of two accelerators, 50-400 kV and 0.4-3 MV, that will cover a wide range of ion beam intensities, with sufficient energy overlap to consistently connect the

  1. "DIANA" - A New, Deep-Underground Accelerator Facility for Astrophysics Experiments

    SciTech Connect

    Leitner, M.; Leitner, D.; Lemut, A.; Vetter, P.; Wiescher, M.

    2009-05-28

    The DIANA project (Dakota Ion Accelerators for Nuclear Astrophysics) is a collaboration between the University of Notre Dame, University of North Carolina, Western Michigan University, and Lawrence Berkeley National Laboratory to build a nuclear astrophysics accelerator facility 1.4 km below ground. DIANA is part of the US proposal DUSEL (Deep Underground Science and Engineering Laboratory) to establish a cross-disciplinary underground laboratory in the former gold mine of Homestake in South Dakota, USA. DIANA would consist of two high-current accelerators, a 30 to 400 kV variable, high-voltage platform, and a second, dynamitron accelerator with a voltage range of 350 kV to 3 MV. As a unique feature, both accelerators are planned to be equipped with either high-current microwave ion sources or multi-charged ECR ion sources producing ions from protons to oxygen. Electrostatic quadrupole transport elements will be incorporated in the dynamitron high voltage column. Compared to current astrophysics facilities, DIANA could increase the available beam densities on target by magnitudes: up to 100 mA on the low energy accelerator and several mA on the high energy accelerator. An integral part of the DIANA project is the development of a high-density super-sonic gas-jet target which can handle these anticipated beam powers. The paper will explain the main components of the DIANA accelerators and their beam transport lines and will discuss related technical challenges.

  2. DIANA-miRPath v3.0: deciphering microRNA function with experimental support

    PubMed Central

    Vlachos, Ioannis S.; Zagganas, Konstantinos; Paraskevopoulou, Maria D.; Georgakilas, Georgios; Karagkouni, Dimitra; Vergoulis, Thanasis; Dalamagas, Theodore; Hatzigeorgiou, Artemis G.

    2015-01-01

    The functional characterization of miRNAs is still an open challenge. Here, we present DIANA-miRPath v3.0 (http://www.microrna.gr/miRPathv3) an online software suite dedicated to the assessment of miRNA regulatory roles and the identification of controlled pathways. The new miRPath web server renders possible the functional annotation of one or more miRNAs using standard (hypergeometric distributions), unbiased empirical distributions and/or meta-analysis statistics. DIANA-miRPath v3.0 database and functionality have been significantly extended to support all analyses for KEGG molecular pathways, as well as multiple slices of Gene Ontology (GO) in seven species (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus and Danio rerio). Importantly, more than 600 000 experimentally supported miRNA targets from DIANA-TarBase v7.0 have been incorporated into the new schema. Users of DIANA-miRPath v3.0 can harness this wealth of information and substitute or combine the available in silico predicted targets from DIANA-microT-CDS and/or TargetScan v6.2 with high quality experimentally supported interactions. A unique feature of DIANA-miRPath v3.0 is its redesigned Reverse Search module, which enables users to identify and visualize miRNAs significantly controlling selected pathways or belonging to specific GO categories based on in silico or experimental data. DIANA-miRPath v3.0 is freely available to all users without any login requirement. PMID:25977294

  3. The formation of red colobus-diana monkey associations under predation pressure from chimpanzees.

    PubMed Central

    Noë, R; Bshary, R

    1997-01-01

    It is generally assumed that most primates live in monospecific or polyspecific groups because group living provides protection against predation, but hard evidence is scarce. We tested the antipredation hypothesis with observational and experimental data on mixed-species groups of red colobus (Procolobus badius) and diana monkeys (Cercopithecus diana) in the Taï National Park, Ivory Coast. Red colobus, but not diana monkeys, are frequently killed by cooperatively hunting chimpanzees. Association rates peaked during the chimpanzees' hunting season, as a result of changes in the behaviour of the red colobus. In addition, playbacks of recordings of chimpanzee sounds induced the formation of new associations and extended the duration of existing associations. No such effects were observed in reaction to control experiments and playbacks of leopard recordings. PMID:9061972

  4. Condolence Books: Language and Meaning in the Mourning for Hillsborough and Diana

    ERIC Educational Resources Information Center

    Brennan, Michael

    2008-01-01

    This article reports empirical research into public books of condolence signed following two key mourning events within British culture: the 1989 Hillsborough soccer stadium disaster and the death of Diana, Princess of Wales, in 1997. The author suggests that not only do condolence books provide valuable historical record of the way contemporary…

  5. Differences in Univariate Values versus Multivariate Relationships: Findings from a Study of Diana, Princess of Wales.

    ERIC Educational Resources Information Center

    Basil, Michael D.; Brown, William J.; Bocarnea, Mihai C.

    2002-01-01

    Addresses the question of whether use of student samples jeopardizes the validity of research. Examines the distinction between univariate and multivariate relationships in a study of identification with Diana, Princess of Wales. Shows that although the estimates of univariate values differed across three samples, the multivariate relationships…

  6. Media, Discourse, and the Public Sphere: Electronic Memorials to Diana, Princess of Wales.

    ERIC Educational Resources Information Center

    Helmers, Marguerite

    2001-01-01

    Addresses the hundreds of web sites devoted to the memory of Diana. Provides a thick description of the way in which people are writing and using the Internet in everyday life, with a special emphasis on the way in which this writing brings them into a public sphere. Concludes that hypermedia offers the immediate sense of audience and community.…

  7. Rotation periods of the asteroids 55 Pandora, 78 Diana and 815 Coppelia

    NASA Astrophysics Data System (ADS)

    Radeva, V.; Dimitrov, D.; Kjurkchieva, D.; Ibryamov, S.

    This paper presents new photometric CCD observations of the asteroids 55 Pandora, 78 Diana and 815 Coppelia with the 50/70 cm Schmidt telescope at Rozhen National Astronomical Observatory during October-November 2010. The rotation periods and amplitudes of light variations of the observed asteroids were determined from the light curves.

  8. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  9. U-Pb age of the Diana Complex and Adirondack granulite petrogenesis

    USGS Publications Warehouse

    Basu, A.R.; Premo, W.R.

    2001-01-01

    U-Pb isotopic analyses of eight single and multi-grain zircon fractions separated from a syenite of the Diana Complex of the Adirondack Mountains do not define a single linear array, but a scatter along a chord that intersects the Concordia curve at 1145 ?? 29 and 285 ?? 204 Ma. For the most concordant analyses, the 207Pb/206Pb ages range between 1115 and 1150 Ma. Detailed petrographic studies revealed that most grains contained at least two phases of zircon growth, either primary magmatic cores enclosed by variable thickness of metamorphic overgrowths or magmatic portions enclosing presumably older xenocrystic zircon cores. The magmatic portions are characterized by typical dipyramidal prismatic zoning and numerous black inclusions that make them quite distinct from adjacent overgrowths or cores when observed in polarizing light microscopy and in back-scattered electron micrographs. Careful handpicking and analysis of the "best" magmatic grains, devoid of visible overgrowth of core material, produced two nearly concordant points that along with two of the multi-grain analyses yielded an upper-intercept age of 1118 ?? 2.8 Ma and a lower-intercept age of 251 ?? 13 Ma. The older age is interpreted as the crystallization age of the syenite and the younger one is consistent with late stage uplift of the Appalachian region. The 1118 Ma age for the Diana Complex, some 35 Ma younger than previously believed, is now approximately synchronous with the main Adirondack anorthosite intrusion, implying a cogenetic relationship among the various meta-igneous rocks of the Adirondacks. The retention of a high-temperature contact metamorphic aureole around Diana convincingly places the timing of Adirondack regional metamorphism as early as 1118 Ma. This result also implies that the sources of anomalous high-temperature during granulite metamorphism are the syn-metamorphic intrusions, such as the Diana Complex.

  10. Study of the beam-induced neutron flux and required shielding for DIANA

    NASA Astrophysics Data System (ADS)

    Best, Andreas; Couder, Manoel; Famiano, Michael; Lemut, Alberto; Wiescher, Michael

    2013-11-01

    Low energy accelerators in underground locations have emerged as a powerful tool for the measurement of critical nuclear reactions for the study of energy production and element synthesis in astrophysics. While cosmic ray induced background is substantially reduced, beam induced background on target impurities and depositions on target and collimator materials remain a matter of serious concern. The Dual Ion Accelerator for Nuclear Astrophysics (DIANA) is proposed to operate as a low-level background facility in an underground location. One of the main goals of DIANA is the study of neutron sources in stellar helium burning. For these experiments DIANA is a neutron radiation source which may affect other nearby low background level experiments. We therefore investigated the required laboratory layout to attenuate the neutron flux generated in a worst-case scenario to a level below the natural background in the underground environment. Detailed Monte Carlo calculations of the neutron propagation in the laboratory show that a neutron flux many orders of magnitude above expected values gets attenuated below the natural background rate using a 1 m thick water-shielded door as well as an emergency access/egress maze.

  11. Tamarugite in the Steam-Condensate Alteration Paragenesis in Diana Cave (SW Romania)

    NASA Astrophysics Data System (ADS)

    Puscas, C. M.; Onac, B. P.; Effenberger, H. S.; Povară, I.

    2012-12-01

    The double-salt hydrate tamarugite [NaAl(SO4)2 6H2O] is an uncommon mineral in the cave environment, forming as a result of chemical reactions between water and bedrock only under very specific conditions. The Diana Cave hosts a unique tamarugite occurrence, the first one to be reported from a typical karst environment. The cave is located within the limits of Băile Herculane township in the Cerna Mountains, SW Romania. It consists of a 14 m long, westward-oriented single passage, developed along the Diana Fault. In 1974 a concrete-clad mine gallery was created to channel the thermal water (Diana 1+2 Spring) flowing through the cave to a pumping station. The spring's chemical and physical parameters fluctuated through time, averaging 51.98° C, discharge of 0.96 Ls-1, pH of 7.46, 5768.66 ppm TDS, 9303 μScm-1 conductivity, 5.02 salinity. The major chemical components of the thermo-mineral water in Diana Cave are, Na+ (1392.57 ppm), K+ (58.55 ppm), Ca2+ (725.16 ppm), Mg2+ (10.78 ppm), Cl- (3376.83 ppm), and SO42- (92.27 ppm), and H2S (24.05 ppm), with traces of Si, Fe2+, Br+, I-, and Li+. The general air circulation pattern within the cave is fairly simple: cold air from the outside sweeps into the cave along the floor, heats up at the contact with the thermo-mineral water, ascends, and exists the cave along the ceiling. At the contact with the cold walls of the Diana Cave, the hot steam condenses and gives rise to a rich and exotic sulfate-mineral paragenesis (including halotrichite-series minerals, gypsum, bassanite, anhydrite, epsomite, alunite, halite, native sulfur, etc.). The most exotic minerals precipitate at or below the contact between the Tithonic - Neocomian limestone and the overlaying Cretaceous shaly limestone, as a result of steam-condensate alteration. Minerogenetic mechanisms responsible for the peculiar sulfate mineral assemblage in Diana Cave are evaporation, oxidation, hydrolysis, double exchange reactions, and deposition from vapours or

  12. 3DIANA: 3D Domain Interaction Analysis: A Toolbox for Quaternary Structure Modeling.

    PubMed

    Segura, Joan; Sanchez-Garcia, Ruben; Tabas-Madrid, Daniel; Cuenca-Alba, Jesus; Sorzano, Carlos Oscar S; Carazo, Jose Maria

    2016-02-23

    Electron microscopy (EM) is experiencing a revolution with the advent of a new generation of Direct Electron Detectors, enabling a broad range of large and flexible structures to be resolved well below 1 nm resolution. Although EM techniques are evolving to the point of directly obtaining structural data at near-atomic resolution, for many molecules the attainable resolution might not be enough to propose high-resolution structural models. However, accessing information on atomic coordinates is a necessary step toward a deeper understanding of the molecular mechanisms that allow proteins to perform specific tasks. For that reason, methods for the integration of EM three-dimensional maps with x-ray and NMR structural data are being developed, a modeling task that is normally referred to as fitting, resulting in the so called hybrid models. In this work, we present a novel application-3DIANA-specially targeted to those cases in which the EM map resolution is medium or low and additional experimental structural information is scarce or even lacking. In this way, 3DIANA statistically evaluates proposed/potential contacts between protein domains, presents a complete catalog of both structurally resolved and predicted interacting regions involving these domains and, finally, suggests structural templates to model the interaction between them. The evaluation of the proposed interactions is computed with DIMERO, a new method that scores physical binding sites based on the topology of protein interaction networks, which has recently shown the capability to increase by 200% the number of domain-domain interactions predicted in interactomes as compared to previous approaches. The new application displays the information at a sequence and structural level and is accessible through a web browser or as a Chimera plugin at http://3diana.cnb.csic.es.

  13. The relationship between acoustic structure and semantic information in Diana monkey alarm vocalization

    NASA Astrophysics Data System (ADS)

    Riede, Tobias; Zuberbühler, Klaus

    2003-08-01

    Mammalian vocal production mechanisms are still poorly understood despite their significance for theories of human speech evolution. Particularly, it is still unclear to what degree mammals are capable of actively controlling vocal-tract filtering, a defining feature of human speech production. To address this issue, a detailed acoustic analysis on the alarm vocalization of free-ranging Diana monkeys was conducted. These vocalizations are especially interesting because they convey semantic information about two of the monkeys' natural predators, the leopard and the crowned eagle. Here, vocal tract and sound source parameter in Diana monkey alarm vocalizations are described. It is found that a vocalization-initial formant downward transition distinguishes most reliably between eagle and leopard alarm vocalization. This finding is discussed as an indication of articulation and alternatively as the result of a strong nasalization effect. It is suggested that the formant modulation is the result of active vocal filtering used by the monkeys to encode semantic information, an ability previously thought to be restricted to human speech.

  14. The relationship between acoustic structure and semantic information in Diana monkey alarm vocalization.

    PubMed

    Riede, Tobias; Zuberbühler, Klaus

    2003-08-01

    Mammalian vocal production mechanisms are still poorly understood despite their significance for theories of human speech evolution. Particularly, it is still unclear to what degree mammals are capable of actively controlling vocal-tract filtering, a defining feature of human speech production. To address this issue, a detailed acoustic analysis on the alarm vocalization of free-ranging Diana monkeys was conducted. These vocalizations are especially interesting because they convey semantic information about two of the monkeys' natural predators, the leopard and the crowned eagle. Here, vocal tract and sound source parameter in Diana monkey alarm vocalizations are described. It is found that a vocalization-initial formant downward transition distinguishes most reliably between eagle and leopard alarm vocalization. This finding is discussed as an indication of articulation and alternatively as the result of a strong nasalization effect. It is suggested that the formant modulation is the result of active vocal filtering used by the monkeys to encode semantic information, an ability previously thought to be restricted to human speech.

  15. [DianaWeb: a demonstration project to improve breast cancer prognosis through lifestyles].

    PubMed

    Villarini, Anna; Villarini, Milena; Gargano, Giuliana; Moretti, Massimo; Berrino, Franco

    2015-01-01

    In the field of cancer prevention, the public ask to be involved more actively in scientific research and in the production of knowledge. This is leading to an increase of participatory projects in the field of epidemiology. Community-based participatory research (CBPR) has received considerable attention in the past 15 years; it is becoming a recognized and important approach in addressing health disparities in cancer prevention. The increasing accessibility of new methods of comparison, discussion and information allows to link a large number of people. The project DianaWeb was born in 2015 at the Department of Predictive Medicine and Prevention of the National Cancer Institute, Milan. This CBPR involves women with diagnosis of breast cancer (BC). DianaWeb communications are based on an interactive online platform developed "ad hoc" (www.dianaweb.org). With very few exceptions, all communication between participants and research team will be on the web. The recruitment is done through Internet, hospitals, physicians, media and word of mouth. Women can join the project independently, under the control of researchers and the aim of the study is to assess whether healthy eating and regular physical activity can improve the quality of life and increase survival rates in women with diagnosis of BC. About 50,000 Italian women with a diagnosis of BC with or without metastasis, local recurrence or second cancers; with in situ or invasive cancer, whatever the disease stage at diagnosis, whatever histological diagnosis, whatever the time elapsed since diagnosis should be recruited in the DianaWeb project. The volunteers are asked to send clinical information about their condition from diagnosis onwards, on their weight and other anthropometric measures, lifestyles and nutrition through online questionnaires. Moreover, the women enrolled in the study, after login, can access evidence-based information and results obtained during the project (individual and whole community

  16. DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows

    PubMed Central

    Paraskevopoulou, Maria D.; Georgakilas, Georgios; Kostoulas, Nikos; Vlachos, Ioannis S.; Vergoulis, Thanasis; Reczko, Martin; Filippidis, Christos; Dalamagas, Theodore; Hatzigeorgiou, A.G.

    2013-01-01

    MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA–gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines. PMID:23680784

  17. How well do preschoolers identify healthy foods? Development and preliminary validation of the Dietary Interview Assessing Nutritional Awareness (DIANA).

    PubMed

    Graziano, Paulo A

    2015-09-01

    The current study aimed to develop and initially validate a brief Dietary Interview Assessing Nutritional Awareness (DIANA) that mapped onto the Stop-Light Diet System. Participants for this study included 69 preschool children (83% boys; mean age = 5.13 years; 86% Latino) recruited from two summer programs. Children were presented with 24 pictures and were asked to name the food and indicate how healthy they felt each food was by pointing to a smiley face (very healthy = Green/Go food), neutral face (somewhat healthy = Yellow/Slow food), or a sad face (not healthy at all = Red/Whoa foods). Psychometric properties of the DIANA were assessed via a baseline assessment while children were re-administered the DIANA within 4-6 weeks to ascertain the test-retest reliability. Discriminant validity was also assessed in an exploratory fashion with a small subsample (n = 11) of children who participated in a healthy-lifestyle intervention program (HIP). Results indicated that the internal consistency of the DIANA for both the expressive knowledge and the health classification scales was acceptable (α = .83 and .82, respectively) along with the test-retest reliability (ICC = .86 and .81, respectively). Lastly, children who participated in HIP experienced greater gains in their ability to classify food based on the Stop-Light System and greater expressive knowledge of Green/Go foods compared to children who did not participate in the intervention suggesting adequate construct validity. These findings highlight the feasibility and utility of the DIANA in assessing young children's knowledge of foods and their relative healthiness as well as its potential sensitivity to intervention effects.

  18. [Horse infestation with the larva of the deer warble fly, Hypoderma diana Brauer, 1985 (Diptera, Hypodermatidae)].

    PubMed

    Minár, J

    1987-03-01

    In South Bohemia a case was discovered of a yearling colt attacked by the larva of the IIIrd instar of the deer warble fly Hypoderma diana Brauer. The dead, almost mature larva of the fly was squeezed out of a subcutaneous lump above the shoulder in the first decade of April, 1985. The case is evaluated from the point of view of the possibility of the transition of specific parasites--warble flies--to another host. The attacking of a non-specific kind can occasionally occur only when there is a large number of the parasites and both kinds of host. At present the degree of attacking of deer by subcutaneous warble flies is high and therefore under favourable circumstances even domestic animals can be attacked by this type of warble fly. The above case is the first to be ascertained of a horse being attacked by a deer warble fly. PMID:3107199

  19. [Horse infestation with the larva of the deer warble fly, Hypoderma diana Brauer, 1985 (Diptera, Hypodermatidae)].

    PubMed

    Minár, J

    1987-03-01

    In South Bohemia a case was discovered of a yearling colt attacked by the larva of the IIIrd instar of the deer warble fly Hypoderma diana Brauer. The dead, almost mature larva of the fly was squeezed out of a subcutaneous lump above the shoulder in the first decade of April, 1985. The case is evaluated from the point of view of the possibility of the transition of specific parasites--warble flies--to another host. The attacking of a non-specific kind can occasionally occur only when there is a large number of the parasites and both kinds of host. At present the degree of attacking of deer by subcutaneous warble flies is high and therefore under favourable circumstances even domestic animals can be attacked by this type of warble fly. The above case is the first to be ascertained of a horse being attacked by a deer warble fly.

  20. Physiological, anatomical and biomass partitioning responses to ozone in the Mediterranean endemic plant Lamottea dianae.

    PubMed

    Calatayud, Vicent; García-Breijo, Francisco J; Cervero, Júlia; Reig-Armiñana, José; Sanz, María José

    2011-07-01

    Ozone effects on the perennial forb Lamottea dianae were studied in an open-top chamber experiment. Ozone was found to induce reductions in CO₂ assimilation and water use efficiency in the leaves of this species. These reductions were mainly related to a decline in the in vivo CO₂ fixation capacity of Rubisco (V(c,max)), rather than to stomatal limitations or photoinhibitory damage (F(v):F(m)). In addition to chloroplast degeneration, other observed effects were callose accumulation, formation of pectinaceous wart-like cell wall exudates and phloem alterations. Moreover, ozone exposure significantly reduced root dry biomass. The possible relevance of these adverse effects for Mediterranean forbs is commented. These results show that endemic plants can be very sensitive to ozone, suggesting that risks associated with this pollutant should be taken into account for conservation purposes.

  1. Age and petrogenesis of the Diana Complex, Adirondack Mountains, New York

    SciTech Connect

    Grant, N.; Yang, Yingping . Dept. of Geology); Cliff, R. . Dept. of Earth Sciences)

    1992-01-01

    U-Pb zircon data show that the Diana Complex was emplaced 1152[plus minus]12 Ma ago along the Carthage-Colton Mylonite Zone (CCMZ), that marks the boundary between the Adirondack Highlands and the Lowlands. The tectonic setting of the Complex is uncertain because granitoid plutons of the same age were emplaced under syntectonic conditions in the Lowlands, while in the Highlands the same plutons have been viewed as anorogenic. Deformation focused on the CCMZ is reflected in whole-rock Rb-Sr isochron age of 1038[plus minus]97 Ma for the Complex. This resetting is typical of granitoid plutons within a 10 km-wide zone across the CCMZ, but is absent outside this zone elsewhere in the Lowlands. Although the chemical continuity of the Complex with Adirondack mafic rocks of the same presumed age demonstrates that crystal fractionation from a basic parent was a likely origin for the Complex, it is probable the magmas were modified by crustal assimilation. For example, the initial [sup 87]Sr/[sup 86]Sr[sub 1152] values for the Complex (0.7042[plus minus]3) are higher than the same ratios for Adirondack mafic rocks (0.7033[plus minus]6), and one zircon fraction lies to the right of the discordia defined by the other four analyzed fractions. The nature and age of the assimilant may be constrained by a metasedimentary xenolith with a whole-rock Rb-Sr isochron age of 1318[plus minus]15 Ma. Changes in TiO[sub 2] and P[sub 2]O[sub 5] abundances and La/Yb values indicate that the crystallization of both accessory (e.g., Fe-Ti oxides, apatite and zircon) and silicate phases were important in the fractionation of the Diana Complex syenites.

  2. DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts

    PubMed Central

    Paraskevopoulou, Maria D.; Vlachos, Ioannis S.; Karagkouni, Dimitra; Georgakilas, Georgios; Kanellos, Ilias; Vergoulis, Thanasis; Zagganas, Konstantinos; Tsanakas, Panayiotis; Floros, Evangelos; Dalamagas, Theodore; Hatzigeorgiou, Artemis G.

    2016-01-01

    microRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like function of lncRNAs introduces an extra layer of complexity in the miRNA interactome. DIANA-LncBase v1 provided a database of experimentally supported and in silico predicted miRNA Recognition Elements (MREs) on lncRNAs. The second version of LncBase (www.microrna.gr/LncBase) presents an extensive collection of miRNA:lncRNA interactions. The significantly enhanced database includes more than 70 000 low and high-throughput, (in)direct miRNA:lncRNA experimentally supported interactions, derived from manually curated publications and the analysis of 153 AGO CLIP-Seq libraries. The new experimental module presents a 14-fold increase compared to the previous release. LncBase v2 hosts in silico predicted miRNA targets on lncRNAs, identified with the DIANA-microT algorithm. The relevant module provides millions of predicted miRNA binding sites, accompanied with detailed metadata and MRE conservation metrics. LncBase v2 caters information regarding cell type specific miRNA:lncRNA regulation and enables users to easily identify interactions in 66 different cell types, spanning 36 tissues for human and mouse. Database entries are also supported by accurate lncRNA expression information, derived from the analysis of more than 6 billion RNA-Seq reads. PMID:26612864

  3. Cephenemyia stimulator and Hypoderma diana infection of roe deer in the Czech Republic over an 8-year period.

    PubMed

    Salaba, Ondrej; Vadlejch, Jaroslav; Petrtyl, Miloslav; Valek, Petr; Kudrnacova, Marie; Jankovska, Ivana; Bartak, Miroslav; Sulakova, Hana; Langrova, Iva

    2013-04-01

    A survey of naso-pharyngeal and subcutaneous myiasis affecting roe deer (Capreolus capreolus) was conducted in the Czech Republic over an 8-year period (1999-2006). A total of 503 bucks and 264 does from six hunting localities were examined. The sampling area comprised predominantly agricultural lowlands and a mountain range primarily covered by forest. Since 1997, the deer have been treated each winter across the board with ivermectin (150 mg/kg, CERMIX® pulvis, Biopharm, CZ). Parasites found were the larvae of Hypoderma diana and Cephenemyia stimulator. There were no significant differences in warble fly infection among captured animals in the individual hunting localities. Overall, 146 (28.8%) of 503 animals (bucks) were infected with Cephenemyia stimulator larvae; body size of the second instar larva reached 13-18 mm. The prevalence ranged from 16.1 to 42.9% per year, and the mean intensity from 6 to 11 larvae per animal. Additionally, a total of 264 roe deer (does) were examined for H. diana larvae, and 77 (29.1%) were found to be positive; body size of the second instar larva reached 17 mm. The prevalence ranged from 18.8 to 50.0% per year, and the mean intensity from 13 to 22 larvae per animal. The results showed that the bot flies, Cephenemyia stimulator as well as H. diana, are common parasites in roe deer in the Czech Republic, and that through the help of treatment (ivermectin), it is possible to keep parasite levels low. The body weights of infected and non-infected H. diana deer did not differ significantly. PMID:23380908

  4. Cephenemyia stimulator and Hypoderma diana infection of roe deer in the Czech Republic over an 8-year period.

    PubMed

    Salaba, Ondrej; Vadlejch, Jaroslav; Petrtyl, Miloslav; Valek, Petr; Kudrnacova, Marie; Jankovska, Ivana; Bartak, Miroslav; Sulakova, Hana; Langrova, Iva

    2013-04-01

    A survey of naso-pharyngeal and subcutaneous myiasis affecting roe deer (Capreolus capreolus) was conducted in the Czech Republic over an 8-year period (1999-2006). A total of 503 bucks and 264 does from six hunting localities were examined. The sampling area comprised predominantly agricultural lowlands and a mountain range primarily covered by forest. Since 1997, the deer have been treated each winter across the board with ivermectin (150 mg/kg, CERMIX® pulvis, Biopharm, CZ). Parasites found were the larvae of Hypoderma diana and Cephenemyia stimulator. There were no significant differences in warble fly infection among captured animals in the individual hunting localities. Overall, 146 (28.8%) of 503 animals (bucks) were infected with Cephenemyia stimulator larvae; body size of the second instar larva reached 13-18 mm. The prevalence ranged from 16.1 to 42.9% per year, and the mean intensity from 6 to 11 larvae per animal. Additionally, a total of 264 roe deer (does) were examined for H. diana larvae, and 77 (29.1%) were found to be positive; body size of the second instar larva reached 17 mm. The prevalence ranged from 18.8 to 50.0% per year, and the mean intensity from 13 to 22 larvae per animal. The results showed that the bot flies, Cephenemyia stimulator as well as H. diana, are common parasites in roe deer in the Czech Republic, and that through the help of treatment (ivermectin), it is possible to keep parasite levels low. The body weights of infected and non-infected H. diana deer did not differ significantly.

  5. The Role of “Vortical” Hot Towers in the Formation of Tropical Cyclone Diana (1984).

    NASA Astrophysics Data System (ADS)

    Hendricks, Eric A.; Montgomery, Michael T.; Davis, Christopher A.

    2004-06-01

    A high-resolution (3-km horizontal grid spacing) near-cloud-resolving numerical simulation of the formation of Hurricane Diana (1984) is used to examine the contribution of deep convective processes to tropical cyclone formation. This study is focused on the 3-km horizontal grid spacing simulation because this simulation was previously found to furnish an accurate forecast of the later stages of the observed storm life cycle. The numerical simulation reveals the presence of vortical hot towers, or cores of deep cumulonimbus convection possessing strong vertical vorticity, that arise from buoyancy-induced stretching of local absolute vertical vorticity in a vorticity-rich prehurricane environment.At near-cloud-resolving scales, these vortical hot towers are the preferred mode of convection. They are demonstrated to be the most important influence to the formation of the tropical storm via a two-stage evolutionary process: (i) preconditioning of the local environment via diabatic production of multiple small-scale lower-tropospheric cyclonic potential vorticity (PV) anomalies, and (ii) multiple mergers and axisymmetrization of these low-level PV anomalies. The local warm-core formation and tangential momentum spinup are shown to be dominated by the organizational process of the diabatically generated PV anomalies; the former process being accomplished by the strong vertical vorticity in the hot tower cores, which effectively traps the latent heat from moist convection. In addition to the organizational process of the PV anomalies, the cyclogenesis is enhanced by the aggregate diabatic heating associated with the vortical hot towers, which produces a net influx of low-level mean angular momentum throughout the genesis.Simpler models are examined to elucidate the underlying dynamics of tropical cyclogenesis in this case study. Using the Sawyer Eliassen balanced vortex model to diagnose the macroscale evolution, the cyclogenesis of Diana is demonstrated to proceed in

  6. Broadcasting the royal role: constructing culturally situated identities in the Princess Diana Panorama interview.

    PubMed

    Abell, J; Stokoe, E H

    2001-09-01

    We examine critically the two traditions of work that have informed discursive approaches to identity: social constructionism and conversation analysis. Within both strands, identity is theorized as a flexible phenomenon that is situated in conversations. But although constructionists locate identity within the social, such work remains at a theoretical and rather abstract level and often fails to interrogate the discursive practices through which identity is constituted. Conversely, this attention to the occasioning of identity in everyday talk is precisely the focus of the second, conversation analytic strand of work. Whereas constructionists attend to the wider cultural positioning of identities, conversation analysts resist commenting upon the social significance of what is constructed in interaction. Conversation analysis is therefore limited by its restricted notion of culture in the study of the situated social self. Despite the apparent conflict between these approaches, we suggest that a synthesis of the two provides a comprehensive framework for analysing identity. Drawing upon the BBC Panorama interview between Martin Bashir and Princess Diana, we explore how culturally situated identities are located in this conversational context. We conclude that analysts must not only attend to the micro-level organization of identities but also engage in a wider understanding of the cultural framework within which they are located.

  7. Diversity and morphological structure of bacterial communities inhabiting the Diana-Hygieia Thermal Spring (Budapest, Hungary).

    PubMed

    Anda, Dóra; Büki, Gabriella; Krett, Gergely; Makk, Judit; Márialigeti, Károly; Erőss, Anita; Mádl-Szőnyi, Judit; Borsodi, Andrea K

    2014-09-01

    The Buda Thermal Karst System is an active hypogenic karst area that offers possibility for the analysis of biogenic cave formation. The aim of the present study was to gain information about morphological structure and genetic diversity of bacterial communities inhabiting the Diana-Hygieia Thermal Spring (DHTS). Using scanning electron microscopy, metal accumulating and unusual reticulated filaments were detected in large numbers in the DHTS biofilm samples. The phyla Actinobacteria, Firmicutes and Proteobacteria were represented by both bacterial strains and molecular clones but phyla Acidobacteria, Chlorobi, Chlorofexi, Gemmatimonadetes, Nitrospirae and Thermotogae only by molecular clones which showed the highest similarity to uncultured clone sequences originating from different environmental sources. The biofilm bacterial community proved to be somewhat more diverse than that of the water sample and the distribution of the dominant bacterial clones was different between biofilm and water samples. The majority of biofilm clones was affiliated with Deltaproteobacteria and Nitrospirae while the largest group of water clones was related to Betaproteobacteria. Considering the metabolic properties of known species related to the strains and molecular clones from DHTS, it can be assumed that these bacterial communities may participate in the local sulphur and iron cycles, and contribute to biogenic cave formation. PMID:25261945

  8. [Effectiveness of oral administration of ivermectin on warble fly larvae (Hypoderma diana B.) in roe deer].

    PubMed

    Lamka, J; Suchý, J; Staud, F

    1996-08-01

    Hypodermosis and cephenemyiosis are largely widespread diseases in roe deer in the conditions of the Czech Republic. Both kinds of parasitosis cause great losses of game. The aim of this study was to test peroral administration of ivermectin with respect to the control of larval stages of hypodermosis (Hypoderma diana B.) in roe deer. Studies were performed on three localities within one three-year study and two 18-month studies. Ivermectin was administered for two days at a daily dose of 0.30 mg/kg body weight during winter game feeding. The shot deer were checked for the presence of larvae throughout the year. Prevalence and intensity of infection were determined. A total of 147 animals were checked in 1992-1994 (Tab.I); prevalence and intensity of infection were very low in comparison with the situation before treatment and with the control group (1994). Similar results were obtained in both shorter studies (Tab. II) performed on 27 animals in total. The results suggest (on the base of detail discussion) that the low values of prevalence and intensity of infection should be taken as partly distorted due to the methodical conditions of checks. The efficacy of ivermectin treatment was complemented by observation of several cases and their results employing direct checks of shot deer (Tab. III), including a six-year observation of a group of 6 to 10 individuals of tame deer treated year by. These results explicitly document the high efficacy of mass peroral ivermectin administration in the control of warble fly larvae. Ivermectin is the first drug suitable for the treatment of roe deer hypodermosis. PMID:8966963

  9. [Effectiveness of oral administration of ivermectin on warble fly larvae (Hypoderma diana B.) in roe deer].

    PubMed

    Lamka, J; Suchý, J; Staud, F

    1996-08-01

    Hypodermosis and cephenemyiosis are largely widespread diseases in roe deer in the conditions of the Czech Republic. Both kinds of parasitosis cause great losses of game. The aim of this study was to test peroral administration of ivermectin with respect to the control of larval stages of hypodermosis (Hypoderma diana B.) in roe deer. Studies were performed on three localities within one three-year study and two 18-month studies. Ivermectin was administered for two days at a daily dose of 0.30 mg/kg body weight during winter game feeding. The shot deer were checked for the presence of larvae throughout the year. Prevalence and intensity of infection were determined. A total of 147 animals were checked in 1992-1994 (Tab.I); prevalence and intensity of infection were very low in comparison with the situation before treatment and with the control group (1994). Similar results were obtained in both shorter studies (Tab. II) performed on 27 animals in total. The results suggest (on the base of detail discussion) that the low values of prevalence and intensity of infection should be taken as partly distorted due to the methodical conditions of checks. The efficacy of ivermectin treatment was complemented by observation of several cases and their results employing direct checks of shot deer (Tab. III), including a six-year observation of a group of 6 to 10 individuals of tame deer treated year by. These results explicitly document the high efficacy of mass peroral ivermectin administration in the control of warble fly larvae. Ivermectin is the first drug suitable for the treatment of roe deer hypodermosis.

  10. Vortical hot towers, their aggregate effects and their resolution dependence in the formation of Hurricane Diana (1984)

    NASA Astrophysics Data System (ADS)

    Hidalgo, Juan Marcus

    Recent authors have hypothesized that small-scale deep convective towers possessing intense values of cyclonic vertical vorticity in their cores (vortical hot towers) play a critical role in tropical cyclogenesis via a two stage process: (1) preconditioning the local environment by creating small-scale potential vorticity anomalies and humidifying the lower to middle troposphere, and (2) merger, axisymmetrization and collection of these potential vorticity anomalies to generate the larger scale vortex. In this study we further investigate the role played by vortical hot towers in the upscale growth process. We simulate the evolution of Hurricane Diana in a full-physics numerical model with 1km grid spacing and compare our results to previous, coarser resolution simulations. We employ traditional weather analysis techniques and new innovative means of displaying large and complex datasets to investigate the interaction between the cloud scale features and the larger system scale environment. The results are compared to prior studies to assess if simulated vortical hot tower dynamics exhibit a significant dependence on model resolution. We find the basic physics of the vortical hot tower pathway is largely unchanged as grid-spacing decreases from 3km to 1km for simulations of Hurricane Diana. The differences between our high resolution simulation and coarser resolution simulations are mainly associated with fine scale variability. Our 1km simulation represents nearly an order of magnitude more convective towers with smaller spatial scales than what was observed in previous simulations. We find maximum updraft velocities in our 1km simulation typically between 15ms-1 and 20ms-1 with instantaneous maximum values as high as 35ms-1, though these values typically decrease during the simulation. We also find that, while the cores in the vortical hot towers are significantly moistened by the vertical transport of moisture in the updraft, the larger-scale environment

  11. DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data.

    PubMed

    Vlachos, Ioannis S; Vergoulis, Thanasis; Paraskevopoulou, Maria D; Lykokanellos, Filopoimin; Georgakilas, Georgios; Georgiou, Penny; Chatzopoulos, Serafeim; Karagkouni, Dimitra; Christodoulou, Foteini; Dalamagas, Theodore; Hatzigeorgiou, Artemis G

    2016-07-01

    Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna.gr/mirextrav2) performs a combined DEA of mRNAs and microRNAs (miRNAs) to uncover miRNAs and transcription factors (TFs) playing important regulatory roles between two investigated states. The web server uses as input miRNA/RNA-Seq read count data sets that can be uploaded for analysis. Users can combine their data with 350 small-RNA-Seq and 65 RNA-Seq in-house analyzed libraries which are provided by DIANA-mirExTra v2.0.The web server utilizes miRNA:mRNA, TF:mRNA and TF:miRNA interactions derived from extensive experimental data sets. More than 450 000 miRNA interactions and 2 000 000 TF binding sites from specific or high-throughput techniques have been incorporated, while accurate miRNA TSS annotation is obtained from microTSS experimental/in silico framework. These comprehensive data sets enable users to perform analyses based solely on experimentally supported information and to uncover central regulators within sequencing data: miRNAs controlling mRNAs and TFs regulating mRNA or miRNA expression. The server also supports predicted miRNA:gene interactions from DIANA-microT-CDS for 4 species (human, mouse, nematode and fruit fly). DIANA-mirExTra v2.0 has an intuitive user interface and is freely available to all users without any login requirement. PMID:27207881

  12. Community-based participatory research to improve life quality and clinical outcomes of patients with breast cancer (DianaWeb in Umbria pilot study)

    PubMed Central

    Villarini, Milena; Lanari, Chiara; Nucci, Daniele; Gianfredi, Vincenza; Marzulli, Tiziana; Berrino, Franco; Borgo, Alessandra; Bruno, Eleonora; Gargano, Giuliana; Moretti, Massimo; Villarini, Anna

    2016-01-01

    Introduction Breast cancer (BC) is the most frequent cancer in Europe and the International Agency for Research on Cancer (IARC) has estimated over 460 000 incident cases per year. Survival among patients with BC has increased in the past decades and EUROCARE-5 has estimated a 5-year relative survival rate of 82% for patients diagnosed in 2000–2007. There is growing evidence that lifestyle (such as a diet based on Mediterranean principles associated with moderate physical activity) may influence prognosis of BC; however, this information is not currently available to patients and is not considered in oncology protocols. Only a few epidemiological studies have investigated the role of diet in BC recurrence and metastasis. Methods and analysis DianaWeb is a community-based participatory research dedicated to patients with BC and represents a collaborative effort between participants and research institutions to determine if specified changes in lifestyle would result in improved outcomes in terms of quality of life or survival. The aim of the study is to recruit a large number of participants, to monitor their lifestyle and health status over time, to provide them tips to encourage sustainable lifestyle changes, to analyse clinical outcomes as a function of baseline risk factors and subsequent changes, and to share with patients methodologies and results. DianaWeb uses a specific interactive website (http://www.dianaweb.org/) and, with very few exceptions, all communications will be made through the web. In this paper we describe the pilot study, namely DianaWeb in Umbria. Ethics and dissemination DianaWeb does not interfere with prescribed oncological treatments; rather, it recommends that participants should follow the received prescriptions. The results will be used to plan guidelines for nutrition and physical activity for patients with BC. The pilot study was approved by the ethics committee of the University of Perugia (reference number 2015-002), and is

  13. DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data

    PubMed Central

    Vlachos, Ioannis S.; Vergoulis, Thanasis; Paraskevopoulou, Maria D.; Lykokanellos, Filopoimin; Georgakilas, Georgios; Georgiou, Penny; Chatzopoulos, Serafeim; Karagkouni, Dimitra; Christodoulou, Foteini; Dalamagas, Theodore; Hatzigeorgiou, Artemis G.

    2016-01-01

    Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna.gr/mirextrav2) performs a combined DEA of mRNAs and microRNAs (miRNAs) to uncover miRNAs and transcription factors (TFs) playing important regulatory roles between two investigated states. The web server uses as input miRNA/RNA-Seq read count data sets that can be uploaded for analysis. Users can combine their data with 350 small-RNA-Seq and 65 RNA-Seq in-house analyzed libraries which are provided by DIANA-mirExTra v2.0. The web server utilizes miRNA:mRNA, TF:mRNA and TF:miRNA interactions derived from extensive experimental data sets. More than 450 000 miRNA interactions and 2 000 000 TF binding sites from specific or high-throughput techniques have been incorporated, while accurate miRNA TSS annotation is obtained from microTSS experimental/in silico framework. These comprehensive data sets enable users to perform analyses based solely on experimentally supported information and to uncover central regulators within sequencing data: miRNAs controlling mRNAs and TFs regulating mRNA or miRNA expression. The server also supports predicted miRNA:gene interactions from DIANA-microT-CDS for 4 species (human, mouse, nematode and fruit fly). DIANA-mirExTra v2.0 has an intuitive user interface and is freely available to all users without any login requirement. PMID:27207881

  14. The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.

    PubMed

    Bemer, Marian; Wolters-Arts, Mieke; Grossniklaus, Ueli; Angenent, Gerco C

    2008-08-01

    MADS box genes in plants consist of MIKC-type and type I genes. While MIKC-type genes have been studied extensively, the functions of type I genes are still poorly understood. Evidence suggests that type I MADS box genes are involved in embryo sac and seed development. We investigated two independent T-DNA insertion alleles of the Arabidopsis thaliana type I MADS box gene AGAMOUS-LIKE61 (AGL61) and showed that in agl61 mutant ovules, the polar nuclei do not fuse and central cell morphology is aberrant. Furthermore, the central cell begins to degenerate before fertilization takes place. Although pollen tubes are attracted and perceived by the mutant ovules, neither endosperm development nor zygote formation occurs. AGL61 is expressed in the central cell during the final stages of embryo sac development. An AGL61:green fluorescent protein-beta-glucoronidase fusion protein localizes exclusively to the polar nuclei and the secondary nucleus of the central cell. Yeast two-hybrid analysis showed that AGL61 can form a heterodimer with AGL80 and that the nuclear localization of AGL61 is lost in the agl80 mutant. Thus, AGL61 and AGL80 appear to function together to differentiate the central cell in Arabidopsis. We renamed AGL61 DIANA, after the virginal Roman goddess of the hunt.

  15. Maternal waist-to-hip ratio as a predictor of newborn size: Results of the Diana Project.

    PubMed

    Brown, J E; Potter, J D; Jacobs, D R; Kopher, R A; Rourke, M J; Barosso, G M; Hannan, P J; Schmid, L A

    1996-01-01

    Location of body fat stores, as indicated by waist-to-hip circumference ratio (WHR), affects a variety of metabolic processes in women, and some of these changes could affect fetal growth during pregnancy. We tested the hypothesis that WHR affects fetal growth among 702 participants of the Diana Project, a prospective study designed to identify preconceptual exposures related to reproductive outcomes. We tested the effect of maternal WHR on the outcomes of infant birthweight, length, and head circumference in regressional models that included 16 variables such as maternal body mass index, duration of gestation, and pregnancy weight gain previously related to birthweight. Maternal WHR was related to each measure of newborn size. A 0.1-unit increase in WHR predicts a 120-gm greater birthweight, a 0.2-inch greater length, and a 0.3-cm greater head circumference. We conclude that WHR is related to fetal growth and that the effect of WHR on fetal growth may be mediated by metabolic alterations associated with a preponderance of central body fat stores or to other factors closely aligned with WHR. The common finding of an independent effect of pregnancy BMI on birthweight may be largely attributable to maternal WHR. PMID:8664403

  16. The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.

    PubMed

    Bemer, Marian; Wolters-Arts, Mieke; Grossniklaus, Ueli; Angenent, Gerco C

    2008-08-01

    MADS box genes in plants consist of MIKC-type and type I genes. While MIKC-type genes have been studied extensively, the functions of type I genes are still poorly understood. Evidence suggests that type I MADS box genes are involved in embryo sac and seed development. We investigated two independent T-DNA insertion alleles of the Arabidopsis thaliana type I MADS box gene AGAMOUS-LIKE61 (AGL61) and showed that in agl61 mutant ovules, the polar nuclei do not fuse and central cell morphology is aberrant. Furthermore, the central cell begins to degenerate before fertilization takes place. Although pollen tubes are attracted and perceived by the mutant ovules, neither endosperm development nor zygote formation occurs. AGL61 is expressed in the central cell during the final stages of embryo sac development. An AGL61:green fluorescent protein-beta-glucoronidase fusion protein localizes exclusively to the polar nuclei and the secondary nucleus of the central cell. Yeast two-hybrid analysis showed that AGL61 can form a heterodimer with AGL80 and that the nuclear localization of AGL61 is lost in the agl80 mutant. Thus, AGL61 and AGL80 appear to function together to differentiate the central cell in Arabidopsis. We renamed AGL61 DIANA, after the virginal Roman goddess of the hunt. PMID:18713950

  17. DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis

    PubMed Central

    Bonfill, Xavier; Osorio, Dimelza; Solà, Ivan; Pijoan, Jose Ignacio; Balasso, Valentina; Quintana, Maria Jesús; Puig, Teresa; Bolibar, Ignasi; Urrútia, Gerard; Zamora, Javier; Emparanza, José Ignacio; Gómez de la Cámara, Agustín; Ferreira-González, Ignacio

    2016-01-01

    Objective To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Methods and Findings Database development and a retrospective analysis. The database DianaHealth.com is already on-line and it is regularly updated, independent, open access and available in English and Spanish. Initiatives are identified in medical news, in article references, and by contacting experts in the field. We include appraisals in the form of clinical recommendations, expert analyses, conclusions from systematic reviews, and original research that label any health care intervention as low-value or inappropriate. We obtain the information necessary to classify the appraisals according to type of intervention, specialties involved, publication year, authoring initiative, and key words. The database is accessible through a search engine which retrieves a list of appraisals and a link to the website where they were published. DianaHealth.com also provides a brief description of the initiatives and a section where users can report new appraisals or suggest new initiatives. From January 2014 to July 2015, the on-line database included 2940 appraisals from 22 initiatives: eleven campaigns gathering clinical recommendations from scientific societies, five sets of conclusions from literature review, three sets of recommendations from guidelines, two collections of articles on low clinical value in medical journals, and an initiative of our own. Conclusions We have developed an open access on-line database of appraisals about healthcare interventions considered of low clinical value or inappropriate. DianaHealth.com could help physicians and other stakeholders make better decisions concerning patient care and healthcare systems sustainability

  18. A novel time-spatial-focusing momentum-correction analyzer for the near-backscattering spectrometer DIANA at J-PARC

    NASA Astrophysics Data System (ADS)

    Takahashi, Nobuaki; Shibata, Kaoru; Sato, Taku J.; Arai, Masatoshi; Mezei, Ferenc

    2008-03-01

    We have developed a novel configuration concept of crystal chips for time-of-flight (TOF) crystal-analyzer neutron inelastic scattering spectrometers, which simultaneously achieve time-focusing, spatial-focusing and momentum-correcting abilities. This concept will be adopted for the planned TOF near-backscattering spectrometer, DIANA which has been proposed for construction at the Japan Proton Accelerator Research Complex (J-PARC). We will first discuss the new analyzer layout method satisfying both time- and spatial-focusing and momentum-correction concepts and then the focusing performances as evaluated by Monte-Carlo simulations and compared to the generally used energy-focusing analyzer configuration.

  19. Geologic framework and hydrogeologic characteristics in the southern part of the Rancho Diana Natural Area, northern Bexar County, Texas, 2008-10

    USGS Publications Warehouse

    Clark, Allan K.; Morris, Robert R.

    2011-01-01

    The area designated by the city of San Antonio as the Rancho Diana Natural Area is in northern Bexar County, near San Antonio, Texas. During 2008-10, the U.S. Geological Survey, in cooperation with the city of San Antonio, documented the geologic framework and mapped the hydrogeologic characteristics for the southern part of the Rancho Diana Natural Area. The geologic framework of the study area and its hydrogeologic characteristics were documented using field observations and information from previously published reports. Many of the geologic and hydrogeologic features were found by making field observations through the dense vegetation along gridlines spaced approximately 25 feet apart and documenting the features as they were located. Surface geologic features were identified and hydrogeologic features such as caves, sinkholes, and areas of solutionally enlarged porosity were located using hand-held Global Positioning System units. The location data were used to create a map of the hydrogeologic subdivisions and the location of karst features. The outcrops of the Edwards and Trinity aquifer recharge zones were mapped by using hydrogeologic subdivisions modified from previous reports. All rocks exposed within the study area are of sedimentary origin and Lower Cretaceous in age. The valley floor is formed in the cavernous member of the upper Glen Rose Limestone of the Trinity Group. The hills are composed of the basal nodular member, dolomitic member, Kirschberg evaporite member, and grainstone member of the Kainer Formation of the Edwards Group. Field observations made during this study of the exposed formations and members indicate that the formations and members typically are composed of mudstones, wackestones, packstones, grainstones, and argillaceous limestones, along with marls. The upper Glen Rose Limestone is approximately 410 to 450 feet thick but only the upper 70 feet is exposed in the study area. The Kainer Formation is approximately 255 feet thick in

  20. The MADS Domain Protein DIANA Acts Together with AGAMOUS-LIKE80 to Specify the Central Cell in Arabidopsis Ovules[W

    PubMed Central

    Bemer, Marian; Wolters-Arts, Mieke; Grossniklaus, Ueli; Angenent, Gerco C.

    2008-01-01

    MADS box genes in plants consist of MIKC-type and type I genes. While MIKC-type genes have been studied extensively, the functions of type I genes are still poorly understood. Evidence suggests that type I MADS box genes are involved in embryo sac and seed development. We investigated two independent T-DNA insertion alleles of the Arabidopsis thaliana type I MADS box gene AGAMOUS-LIKE61 (AGL61) and showed that in agl61 mutant ovules, the polar nuclei do not fuse and central cell morphology is aberrant. Furthermore, the central cell begins to degenerate before fertilization takes place. Although pollen tubes are attracted and perceived by the mutant ovules, neither endosperm development nor zygote formation occurs. AGL61 is expressed in the central cell during the final stages of embryo sac development. An AGL61:green fluorescent protein–β-glucoronidase fusion protein localizes exclusively to the polar nuclei and the secondary nucleus of the central cell. Yeast two-hybrid analysis showed that AGL61 can form a heterodimer with AGL80 and that the nuclear localization of AGL61 is lost in the agl80 mutant. Thus, AGL61 and AGL80 appear to function together to differentiate the central cell in Arabidopsis. We renamed AGL61 DIANA, after the virginal Roman goddess of the hunt. PMID:18713950

  1. The influence of environmental parameters in the biocolonization of the Mithraeum in the roman masonry of casa di Diana (Ostia Antica, Italy).

    PubMed

    Scatigno, C; Moricca, C; Tortolini, C; Favero, G

    2016-07-01

    The microclimatic parameters (Ta, RH, E, and CO2) reflect the indoor quality of the environment. Their relationship, connected with the design of the building, can facilitate the growth of photo/heterotrophic organisms and therefore facilitate the increase of the relative CO2 production. Taking this into account, the impact of biological proliferation in a historical building is discussed for the Mithraeum of "Casa di Diana" in the archaeological site of Ostia Antica, which is subjected to guided tours. In this work, for the first time, we propose a study on biological monitoring to evaluate the contribution of bioactivity to air quality, with the objective to increase the comfort of visitors and to open the site for more than one day per week, suggesting possible tools providing a good compromise between building conservation and human comfort. In the sense, it has been possible to distinguish the contribution of the plants from the one deriving from humans: high values of carbon dioxide have been recorded during the night and its scarce removal during the day (air flow). The window present is not sufficient to eliminate the CO2, involving concentrations of CO2 relatively high in comparison to the proposed limits and guidelines defined by law. The obtained results strongly encouraged the elimination of flora in order to increase the comfort of visitors and to open the house for more than one day per week. Although, this process involves an important economic effort, the present study allows making an objective decision which has an important value in a cultural heritage management. Graphical Abstract CO2 contribute by bioactivity as damage to human health.

  2. First detection of Echinococcus multilocularis infection in two species of nonhuman primates raised in a zoo: a fatal case in Cercopithecus diana and a strongly suspected case of spontaneous recovery in Macaca nigra.

    PubMed

    Yamano, Kimiaki; Kouguchi, Hirokazu; Uraguchi, Kohji; Mukai, Takeshi; Shibata, Chikako; Yamamoto, Hideaki; Takaesu, Noboru; Ito, Masaki; Makino, Yoshinori; Takiguchi, Mitsuyoshi; Yagi, Kinpei

    2014-08-01

    The causative parasite of alveolar echinococcosis, Echinococcus multilocularis, maintains its life cycle between red foxes (Vulpes vulples, the definitive hosts) and voles (the intermediate hosts) in Hokkaido, Japan. Primates, including humans, and some other mammal species can be infected by the accidental ingestion of eggs in the feces of red foxes. In August 2011, a 6-year-old zoo-raised female Diana monkey (Cercopithecus diana) died from alveolar echinococcosis. E. multilocularis infection was confirmed by histopathological examination and detection of the E. multilocularis DNA by polymerase chain reaction (PCR). A field survey in the zoo showed that fox intrusion was common, and serodiagnosis of various nonhuman primates using western blotting detected a case of a 14-year-old female Celebes crested macaque (Macaca nigra) that was weakly positive for E. multilocularis. Computed tomography revealed only one small calcified lesion (approximately 8mm) in the macaque's liver, and both western blotting and enzyme-linked immunosorbent assay (ELISA) showed a gradual decline of antibody titer. These findings strongly suggest that the animal had recovered spontaneously. Until this study, spontaneous recovery from E. multilocularis infection in a nonhuman primate had never been reported.

  3. Diana's Eulogy: Breaking New Ground in Epideictic Rhetoric?

    ERIC Educational Resources Information Center

    Scott, David K.

    A speech in response to an individual's death is by nature a recurring form of rhetoric. Based on audience expectations and needs, certain generic aspects have emerged to characterize eulogies. The funeral oration has generally been recognized as a form of epideictic rhetoric. Modern scholars have generally broadly defined epideictic rhetoric to…

  4. Disease-modifying anti-rheumatic drugs improve autonomic neuropathy in arthritis: DIANA study.

    PubMed

    Syngle, Ashit; Verma, Inderjeet; Krishan, Pawan; Garg, Nidhi; Syngle, Vijaita

    2015-07-01

    Autonomic neuropathy (AN) is a risk predictor for sudden cardiac death in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, the impact of most commonly employed disease-modifying anti-rheumatic drug (DMARD) therapy on autonomic neuropathy in rheumatic diseases is not known. Hence, we investigated the efficacy of DMARDs on autonomic neuropathy in RA and AS. We performed autonomic function assessment in 60 patients in this open-label, 12-week pilot study including 42 patients with RA, 18 with AS, and 30 aged-matched healthy subjects. The methodology included assessment of cardiovascular autonomic reflex tests according to Ewing. Parasympathetic dysfunction was established by performing three tests: heart rate response to deep breathing, standing, and Valsalva tests. Sympathetic dysfunction was examined by applying two tests: blood pressure response to standing and handgrip tests. Sudomotor function was assessed by Sudoscan. Cardiovascular reflex tests were impaired significantly among the patients as compared to healthy subjects (p < 0.05). Autonomic neuropathy was more pronounced in biologic-naive RA and AS patients. After treatment with combination synthetic DMARDs, parasympathetic, and sudomotor dysfunction significantly (p < 0.05) improved in RA and AS. Biologic DMARDs significantly improved parasympathetic, sympathetic and peripheral sympathetic autonomic neuropathy (p < 0.05) in biologic-naive RA and AS patients. In conclusion, synthetic DMARDs improved parasympathetic and sudomotor dysfunction in both DMARD-naive RA and AS patients. However, biologic DMARDs improved parasympathetic, sympathetic and sudomotor dysfunction to a greater extent than synthetic DMARDs in both RA and AS patients. PMID:24928343

  5. The heirs of Aradia, daughters of Diana: community in the second and third wave.

    PubMed

    Dickie, Jane R; Cook, Anna; Gazda, Rachel; Martin, Bethany; Sturrus, Elizabeth

    2005-01-01

    What happens when young third wave feminists learn from second wave feminists what living in community means? This article gives an account of engagement between generations of second and third wave feminists as the younger women began documenting the herstory of Aradia, a radical, separatist and mostly lesbian community and non-profit organization in conservative West Michigan in the 1970s and 1980s. The younger women learned the importance of non-hierarchical political organizing to counter differences of experience and power. They learned that divisions of work and play prevent the development of community and that "high play" is critically important for creative energy and insight. And they learned that mythmaking is more than fantasy; it creates reality. The older women learned that for the third wave identity and sexuality are more fluid. They learned that the younger feminists recognized and valued their contributions, and sought to carry feminist goals forward. Both generations were empowered by the encounter and learned the radical effects of women speaking across generations. PMID:19780268

  6. Seeking a "Mexicana/Mestiza" Critical Feminist Ethic of Care: Diana's "Revolución" of Body and Being

    ERIC Educational Resources Information Center

    Sosa-Provencio, Mia Angélica

    2016-01-01

    This Chicana Critical Feminist Testimonio reveals a Mexican/Mexican-American Ethic of Care and Testimonios of struggle and survival informing curriculum and pedagogy of one Mexican/Mexican-American female educator of predominantly Mexican/Mexican-American students. This work is part of a larger ethnographic study conducted through multiple…

  7. Approaches to Research Priorities for Policy: A Comparative Study. Occasional Paper

    ERIC Educational Resources Information Center

    Wilkinson, Diana

    2010-01-01

    Diana Wilkinson, Chief Social Researcher with the Scottish Government, assisted National Centre for Vocational Education Research (NCVER) to facilitate a forum to discuss the development of national research priorities for the vocational education and training sector. This paper summarises Diana Wilkinson's impression of the forum and uses two…

  8. Perspectives on Adults Learning Mathematics: Research and Practice. Mathematics Education Library.

    ERIC Educational Resources Information Center

    Coben, Diana, Ed.; O'Donoghue, John, Ed.; FitzSimons, Gail E., Ed.

    This book contains 22 papers that are designed to situate research and practice in adults learning mathematics within the wider field of lifelong learning and lifelong education. The following papers are included: "Introduction" (Diana Coben, Gail E. FitzSimons, John O'Donoghue); "Review of Research on Adults Learning Mathematics" (Diana Coben);…

  9. Microbial Extracellular Enzyme Activity and Community Assembly Processes Post Fire Disturbance Amanda Labrado, University of Texas at El Paso; Emily B. Graham, University of Colorado Boulder; Joseph E. Knelman, University of Colorado Boulder; Scott Ferrenberg, University of Colorado Boulder; Diana R. Nemergut, University of Colorado Boulder

    NASA Astrophysics Data System (ADS)

    Labrdo, A.; Knelman, J. E.; Graham, E. B.; Ferrenberg, S.; Nemergut, D. R.

    2013-12-01

    Microbes control major biogeochemical cycles and can directly impact the carbon, nitrogen, and phosphorus pools and fluxes of soils. However, many questions remain regarding when and where data on microbial community structure are necessary to accurately predict biogeochemical processes. In particular, it is unknown how shifts in microbial assembly processes may relate to changes in the relationship between community structure and ecosystem function. Here, we examine soil microbial community assembly processes and extracellular enzyme activity (EEA) at 4-weeks and 16-weeks after the Fourmile Canyon Fire in Boulder, CO in order to determine the effects of disturbance on community assembly and EEA. Microbial community structure was determined from 16S rRNA gene pyrosequencing, edaphic properties were determined using standard biogeochemical assays, and extracellular enzyme activity for β-1, 4-glucosidase (BG) and β-1, 4-N-acetylglucosaminidase (NAG) enzymes were determined using fluorimetric assays. Stepwise linear regressions were used to determine the effects of microbial community structure and edaphic factors on EEA. We determined that in 4-week post fire samples EEA was only correlated with microbial predictors. However, we observed a shift with 16-week samples in which EEA was significantly related to edaphic predictors. Null derivation analysis of community assembly revealed that communities in the 4-week samples were more neutrally assembled than communities in the 16-week samples. Together, these results support a conceptual model in which the relationship between edaphic factors and ecosystem processes is somewhat decoupled in more neutrally assembled communities, and data on microbial community structure is important to most accurately predict function.

  10. Interactive energy atlas for Colorado and New Mexico: an online resource for decisionmakers and the public

    USGS Publications Warehouse

    Carr, N.B.; Babel, N.; Diffendorfer, J.; Ignizio, D.; Hawkins, S.; Latysh, N.; Leib, K.; Linard, J.; Matherne, A.

    2012-01-01

    Throughout the western United States, increased demand for energy is driving the rapid development of oil, gas (including shale gas and coal-bed methane), and uranium, as well as renewable energy resources such as geothermal, solar, and wind. Much of the development in the West is occurring on public lands, including those under Federal and State jurisdictions. In Colorado and New Mexico, these public lands make up about 40 percent of the land area. Both states benefit from the revenue generated by energy production, but resource managers and other decisionmakers must balance the benefits of energy development with the potential consequences for ecosystems, recreation, and other resources. Although a substantial amount of geospatial data on existing energy development and energy potential is available, much of this information is not readily accessible to natural resource decisionmakers, policymakers, or the public. Furthermore, the data often exist in varied formats, requiring considerable processing before these datasets can be used to evaluate tradeoffs among resources, compare development alternatives, or quantify cumulative impacts. To allow for a comprehensive evaluation among different energy types, an interdisciplinary team of U.S. Geological Survey (USGS) scientists has developed an online Interactive Energy Atlas for Colorado and New Mexico. The Energy and Environment in the Rocky Mountain Area (EERMA) interdisciplinary team includes investigators from several USGS science centers1. The purpose of the EERMA Interactive Energy Atlas is to facilitate access to geospatial data related to energy resources, energy infrastructure, and natural resources that may be affected by energy development. The Atlas is designed to meet the needs of various users, including GIS analysts, resource managers, policymakers, and the public, who seek information about energy in the western United States. Currently, the Atlas has two primary capabilities, a GIS data viewer and an

  11. Asteroid Lightcurve Analysis from Volunteer Observatory December 2006 to April 2007

    NASA Astrophysics Data System (ADS)

    Fleenor, Michael L.

    2007-09-01

    Lightcurve period and amplitude results for eight asteroids observed at Volunteer Observatory during December 2006 to April 2007 are reported: 78 Diana, 623 Chimaera, 888 Parysatis, 1502 Arenda, 1602 Indiana, 3497 Innanen, 4374 Tadamori, and (34777) 2001RH.

  12. 78 FR 70088 - Advisory Committee on Veterans Business Affairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... regarding our veterans' resources and partners, please visit our Web site at www.sba.gov/vets . FOR FURTHER... at www.sba.gov/vets . Dated: November 14, 2013 Diana Doukas, SBA Committee Management...

  13. Lightcurve Analysis of Ten Main-belt Asteroids

    NASA Astrophysics Data System (ADS)

    Fauerbach, Michael; Marks, Scott A.; Lucas, Michael P.

    2008-06-01

    We report lightcurve periods for ten main-belt asteroids observed at the Evelyn L. Egan Observatory: 26 Proserpina, 78 Diana, 242 Kriemhild, 287 Nephthys, 348 May, 368 Haidea, 446 Aeternitas, 872 Holda, 905 Universitas, and 1013 Tombecka.

  14. CCD Photometry of Seven Asteroids at the Belgrade Astronomical Observatory

    NASA Astrophysics Data System (ADS)

    Benishek, Vladimir

    2008-03-01

    CCD photometry of seven asteroids was performed at the Belgrade Astronomical Observatory from July 2006 to August 2007: 78 Diana, 125 Liberatrix, 702 Alauda, 888 Parysatis, 1095 Tulipa, 1293 Sonja, and 2006 VV2.

  15. For Children Only.

    ERIC Educational Resources Information Center

    Marcus, Clare Cooper

    2001-01-01

    Illustrates how a London playground dedicated to Princess Diana's memory challenges the preconceptions on which most American playgrounds are designed. The playground's layout and theme are described, and several photographs are included. (GR)

  16. Who Drinks More -- Couples or Singles?

    MedlinePlus

    ... author Diana Dinescu, a doctoral candidate in clinical psychology at the University of Virginia. The researchers looked ... were published recently in the Journal of Family Psychology . SOURCE: University of Virginia, news release, Aug. 11, ...

  17. Sofia Ionescu, the first woman neurosurgeon in the world.

    PubMed

    Ciurea, Alexandru-Vlad; Moisa, Horatiu Alexandru; Mohan, Dumitru

    2013-11-01

    The authors present the activity of Mrs. Sofia Ionescu, the one female surgeon who was nominated as the first woman neurosurgeon in the world. Sofia Ionescu worked in the field of neurosurgery for 47 years, performing all the known neurosurgical procedures of the time. She made herself known through her incredible surgical skill and her enormous work power. Due to her incredible modesty and workload, she never participated at international congresses or manifestations. The nomination as first woman neurosurgery took place in Marrakech, Morocco, during the 2005 WFNS Congress. Although some claim that Diana Beck was the first woman neurosurgeon in the world, our theory suggests otherwise. The first documented surgical intervention performed by Diana Beck dates to 1952. Sofia Ionescu operated for the first time on a human brain as early as 1944. Furthermore, Diana Beck's actions surfaced in the year 1947, long after the war had ended and Sofia Ionescu had become a neurosurgeon.

  18. [The height target prediction by the Tanner method infra evaluates the final height in youths from the rural area of South East Spain].

    PubMed

    Ríos, Rafael; Bosch, Vicente; Santonja, Fernando; López, José Manuel; Garaulet, Marta

    2014-10-16

    Introducción: Conocer la talla final de un individuo antes de finalizar el crecimiento presenta utilidad clínica para el seguimiento de la salud infantil. Objetivo: Calcular la talla diana de una población rural del sudeste de España y comparar con la talla final alcanzada. Métodos: Fueron incluidos 50 jóvenes de 18 a 22 años (44% hombres) y 100 progenitores. La selección de los jóvenes se realizó en 2 fases: 1. Estudio retrospectivo a partir de historias clínicas. 2. Estudio prospectivo: reclutamiento y determinaciones antropométricas. Se calculó talla diana y el desvío de talla. Resultados: La talla final de los chicos fue de 4,44 cm superior a la talla diana (p.

  19. Sofia Ionescu, the first woman neurosurgeon in the world.

    PubMed

    Ciurea, Alexandru-Vlad; Moisa, Horatiu Alexandru; Mohan, Dumitru

    2013-11-01

    The authors present the activity of Mrs. Sofia Ionescu, the one female surgeon who was nominated as the first woman neurosurgeon in the world. Sofia Ionescu worked in the field of neurosurgery for 47 years, performing all the known neurosurgical procedures of the time. She made herself known through her incredible surgical skill and her enormous work power. Due to her incredible modesty and workload, she never participated at international congresses or manifestations. The nomination as first woman neurosurgery took place in Marrakech, Morocco, during the 2005 WFNS Congress. Although some claim that Diana Beck was the first woman neurosurgeon in the world, our theory suggests otherwise. The first documented surgical intervention performed by Diana Beck dates to 1952. Sofia Ionescu operated for the first time on a human brain as early as 1944. Furthermore, Diana Beck's actions surfaced in the year 1947, long after the war had ended and Sofia Ionescu had become a neurosurgeon. PMID:23528794

  20. "The black and white of it": Barbara Grier editing and publishing women of color.

    PubMed

    Enszer, Julie R

    2014-01-01

    In the 1970s and 1980s, lesbian-feminist writing and publishing expressed new theoretical insights about race and envisioned new, intersectional identities. Using texts published and edited by Grier in The Ladder and subsequent Ladder anthologies published by Diana Press, archival documents from Diana Press, and the Grier-Naiad Press papers, this article explores Grier's editorial practices and compares Grier's work to other lesbian-feminist editors and publishers to illuminate different generational understandings of racial-ethnic and class formations within lesbianism and feminism and highlight some of the strategies that White publishers like Grier utilized to realize a vision of multicultural publishing.

  1. "The black and white of it": Barbara Grier editing and publishing women of color.

    PubMed

    Enszer, Julie R

    2014-01-01

    In the 1970s and 1980s, lesbian-feminist writing and publishing expressed new theoretical insights about race and envisioned new, intersectional identities. Using texts published and edited by Grier in The Ladder and subsequent Ladder anthologies published by Diana Press, archival documents from Diana Press, and the Grier-Naiad Press papers, this article explores Grier's editorial practices and compares Grier's work to other lesbian-feminist editors and publishers to illuminate different generational understandings of racial-ethnic and class formations within lesbianism and feminism and highlight some of the strategies that White publishers like Grier utilized to realize a vision of multicultural publishing. PMID:25298098

  2. El Papel de los Padres en el Desarrollo de la Competencia Social (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    ERIC Educational Resources Information Center

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  3. Masculinities in Dialogue: A Response

    ERIC Educational Resources Information Center

    Knights, Ben

    2011-01-01

    This response to the articles by Diana Wallace and Samantha Pinto seeks to locate the negotiation of gendered identities in the classroom within the larger study of the dialogic relations between texts, teachers, and students. Teaching, it proposes, is not a second-order derivative of scholarship, but a cultural form in its own right. The article…

  4. Assessing Individuals with Disabilities in Educational, Employment, and Counseling Settings.

    ERIC Educational Resources Information Center

    Ekstrom, Ruth B., Ed.; Smith, Douglas K., Ed.

    This book is designed to assist testing professionals as they face the challenge of how best to assess and test people with disabilities. Chapters include: (1) "Testing Individuals with Disabilities: Reconciling Social Science and Social Policy" (Diana Pullin); (2) "The Psychometrics of Testing Individuals with Disabilities" (Kurt F. Geisinger and…

  5. Edith Wharton: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Howe, Irving, Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Irving Howe, Edmund Wilson, Louis Auchincloss, Percy Lubbock, E. K. Brown, Q. D. Lewis, Alfred Kazin, Diana Trilling, Blake Nevius, Lionel Trilling, Vernon L. Parrington, and Louis O. Coxe--all dealing with the biography…

  6. Working with Staff Using Baumrind's Parenting Styles Framework

    ERIC Educational Resources Information Center

    Veldhuis, Hollace Anne

    2012-01-01

    The author's presentation at the staff meeting centered on Diana Baumrind's parenting styles framework (Baumrind, 1967). Baumrind believed that there were four requirements for effective guidance: nurturing, communication, maturity demands, and control. She rated parents on these four dimensions and identified the pattern of parenting that…

  7. The Puerto Ricans: Their History, Culture, and Society.

    ERIC Educational Resources Information Center

    Lopez, Adalberto, Ed.

    Articles in this book cover Puerto Rican history from the Spanish colonization to the present day experience of Puerto Ricans in the United States. Political, social, economic, cultural, and historical issues are addresed by the following authors: Edna Acosta-Belen, Frank Bonilla, Juan Manuel Carrion, Diana Christopulos, Sandra Messinger Cypess,…

  8. Recent Litigation in the Placement of Minority Group Children in the Southwest.

    ERIC Educational Resources Information Center

    Sierra, Viola

    Reviewed are some of the legal challenges aimed against the misplacement of minority group children in low ability groups in southwestern states. Court cases covered include Ruiz vs. State Board of Education, Spangles vs. Board of Education, Diana vs. Board of Education, Arreola vs. Board of Education, Covarrubias vs. San Diego, Larry P. vs.…

  9. Suffixation influences receivers' behaviour in non-human primates

    PubMed Central

    Coye, Camille; Ouattara, Karim; Zuberbühler, Klaus; Lemasson, Alban

    2015-01-01

    Compared to humans, non-human primates have very little control over their vocal production. Nonetheless, some primates produce various call combinations, which may partially offset their lack of acoustic flexibility. A relevant example is male Campbell's monkeys (Cercopithecus campbelli), which give one call type (‘Krak’) to leopards, while the suffixed version of the same call stem (‘Krak-oo’) is given to unspecific danger. To test whether recipients attend to this suffixation pattern, we carried out a playback experiment in which we broadcast naturally and artificially modified suffixed and unsuffixed ‘Krak’ calls of male Campbell's monkeys to 42 wild groups of Diana monkeys (Cercopithecus diana diana). The two species form mixed-species groups and respond to each other's vocalizations. We analysed the vocal response of male and female Diana monkeys and overall found significantly stronger vocal responses to unsuffixed (leopard) than suffixed (unspecific danger) calls. Although the acoustic structure of the ‘Krak’ stem of the calls has some additional effects, subject responses were mainly determined by the presence or the absence of the suffix. This study indicates that suffixation is an evolved function in primate communication in contexts where adaptive responses are particularly important. PMID:25925101

  10. 77 FR 63314 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Pearl Street, Dallas, Texas 75201-2272: 1. James Leon Bradley, Sr., individually and as Trustee of the Bradley 2012 Irrevocable Trust; The Bradley 2012 Irrevocable Trust; Diana McBay Bradley, James Leon Bradley, Jr.; and Christopher Richard Bradley, all of Groesbeck, Texas; and Bryan Lee Bradley,...

  11. Perceived Advantages and Disadvantages of Being a Female Graduate Student in the US and the UK

    ERIC Educational Resources Information Center

    Mehta, Clare Marie; Keener, Emily; Shrier, Lydia

    2013-01-01

    We build on Diana Leonard's work on gender and graduate education by qualitatively investigating the perceived advantages and disadvantages of being a female graduate student in the USA and the UK. We interviewed six female students (ages 22-30) pursuing master's degrees in psychology or social sciences in the USA and the UK. Students…

  12. Student Learning Outcomes Assessment Materials Guidebook

    ERIC Educational Resources Information Center

    ACPA College Student Educators International, 2011

    2011-01-01

    The American College Personnel Association's (ACPA's) Sustainability Task Force partnered with the Commission on Assessment and Evaluation with the goal of creating assessment tools to help ACPA members effectively measure student learning around sustainability. Towards these ends, Kimberly Yousey-Elsener (StudentVoice), Diana Richter Keith…

  13. Working Papers in Educational Linguistics, Volume 11, Number 1.

    ERIC Educational Resources Information Center

    Nabors, Leslie K., Ed.; And Others

    1995-01-01

    Five papers on applied linguistics in educational contexts are presented. "What Can Second Language Learners Learn from Each Other? Only Their Researcher Knows for Sure" (Teresa Pica, Felicia Lincoln-Porter, Diana Paninos, Julian Linnell) presents further research on interaction and negotiation among language learners. "Collaborative Effort…

  14. One-Stop Shopping: A Library-Based Corporate Information System.

    ERIC Educational Resources Information Center

    Handman, Pamela L.; Ziegler, Diane L.

    1991-01-01

    Describes the Cetus Corporation library's online information system, called ISCLine (Information Services Center Line). Menu options are explained, system maintenance is described, the use of the system by employees and staff is examined, and future possibilities are considered. A sidebar by Diana L. Ziegler describes programing procedures for…

  15. Citizenship Education Research in Varied Contexts: Reflections and Future Possibilities. A Review Essay

    ERIC Educational Resources Information Center

    Tudball, Libby

    2015-01-01

    Three books are the subject of this review essay: (1) Avril Keating's (2014) publication, "Education for Citizenship in Europe: European Policies, National Adaptations and Young People's Attitudes"; (2) "The Political Classroom: Evidence and Ethics in Democratic Education", Diana Hess and Paula McAvoy (2015); and (3) "We…

  16. Pedagogy Journal, 1998.

    ERIC Educational Resources Information Center

    Marashio, Paul, Ed.

    1998-01-01

    This annual serial volume contains 13 articles offering practical pedagogical ideas from faculty at New Hampshire Technical Colleges. After a brief preface, the following articles are presented: (1) "Variety Is the Spice of Learning," by Sandra Cole; (2) "Separating the Wheat from the Chaff at the Annual Conference," by Diana Wyman; (3) "Teaching…

  17. Princesses and Princes.

    ERIC Educational Resources Information Center

    Harvey, Geeta

    1999-01-01

    Describes an art lesson for second graders inspired by the loss of Princess Diana and Mother Theresa entitled "Princes, Princesses, Heroes and Heroines." Attempts to relate to the children's personal lives and focuses on people who, in the minds of the children, changed or improved the world. (CMK)

  18. Abraham Lincoln and the Pillars of Liberty

    ERIC Educational Resources Information Center

    Schaub, Diana J.

    2002-01-01

    In this essay, Diana Schaub, associate professor and chair of the Department of Political Science at Loyola College in Maryland, asserts that the 9/11 attack on America showed students the fallacy not of relativism, but of toleration. They are now aware that there are limits to toleration. By giving such a vivid display of the horrors of…

  19. Should Teachers Help Students Develop Partisan Identities?

    ERIC Educational Resources Information Center

    Hess, Diana E.; McAvoy, Paula

    2014-01-01

    Five years ago, Diana Hess was teaching a graduate seminar called "Democratic Education." The purpose of the seminar was to critically analyze two seemingly simple, but actually very complex, questions: What is democracy? What is democratic education? Both are contested concepts, and the seminar was designed to help students understand…

  20. Sex Differences in the Development of Moral Reasoning: A Rejoinder to Baumrind.

    ERIC Educational Resources Information Center

    Walker, Lawrence J.

    1986-01-01

    Addresses the criticisms of Diana Baumrind's review of his research on sex differences in moral reasoning development. Discusses issues such as the nature of moral development, the focus on adulthood, the choice of statistics, the effect of differing sample sizes and scoring systems, and the role of sexual experiences in explaining variability in…

  1. Handbook of Parenting. Volume 5: Practical Issues in Parenting. Second Edition.

    ERIC Educational Resources Information Center

    Bornstein, Marc H., Ed.

    Concerned with practical aspects of meeting children's needs, this volume, the fifth of five on parenting, describes the nuts and bolts of parenting as well as the promotion of positive parenting practices. The volume consists of the following 19 chapters: (1) "The Ethics of Parenting" (Diana Baumrind and Ross A. Thompson; (2) "Parenting and…

  2. JiaZhang Dui ErTong FaZhan TongBan GuanXi De ZuoYong (The Role of Parents in the Development of Peer Group Competence). ERIC Digest.

    ERIC Educational Resources Information Center

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  3. The Role of Parents in the Development of Peer Group Competence. ERIC Digest.

    ERIC Educational Resources Information Center

    Moore, Shirley G.

    Among studies that have examined the relationship between parenting styles and children's development of social skills, the research of Diana Baumrind is noteworthy. In several studies, she has identified authoritarian, permissive, and authoritative parenting styles, which differ on the dimensions of nurturance and parental control. Authoritarian…

  4. Good/Bad Girls Read Together: Pre-Adolescent Girls' Co-Authorship of Feminine Subject Positions during a Shared Reading Event.

    ERIC Educational Resources Information Center

    Enciso, Patricia E.

    1998-01-01

    Discusses reading with pre-teens Francine Pascal's "Sweet Valley Twins: Best Friends," one of a series of pre-romance novels featuring identical twin sisters. Interviews six girls using the Symbolic Representation Interview (SRI) about the good girl/bad girl dichotomy in novels and other media. Provides comments by Tom Romano and Diana Mitchell.…

  5. Parents as Leaders: The Role of Control and Discipline.

    ERIC Educational Resources Information Center

    Yahraes, Herbert

    This paper reviews Diana Baumrind's studies of the effect of various types of parental control on children's behavior and concludes that a child is more likely to develop a sense of competence, responsibility, and independence if he or she is given firm and reasonable guidelines. A brief survey of Baumrind's first two studies of preschool children…

  6. Sharing Educational Resources Worldwide: An Interview with Shimizu Yasutaka

    ERIC Educational Resources Information Center

    Oblinger, Diana G.

    2006-01-01

    Shimizu Yasutaka is President of the National Institute of Multimedia Education (NIME) and Professor Emeritus at the Tokyo Institute of Technology. After meeting with Shimizu in December 2005 in Washington, D.C., and in January 2006 in Tokyo, Japan, EDUCAUSE Vice President Diana G. Oblinger asked him some questions about NIME, about IT in Japanese…

  7. The Spanish-Language Roundtable.

    ERIC Educational Resources Information Center

    Criticas: An English Speaker's Guide to the Latest Spanish Language Titles, 2003

    2003-01-01

    Reports on a meeting with a group of experts including Leylha Ahuile, Rene Alegria, Rueben Martinez, Diana Martinez Calice, Silvia Matute, Anne Messitte, and Teresa Mlawer from the Spanish language market for books. Topics include publishing; school and library markets; bookstores; the role of the Latino press and Latino authors; coverage in…

  8. Flexible Learning Strategies in Higher and Further Education.

    ERIC Educational Resources Information Center

    Thomas, Diana, Ed.

    This book contains 15 papers written by contributors from all areas of Great Britain in further and higher education. The following papers are included: "Learning to Be Flexible" (Diana Thomas); "Managing Change: Towards a New Paradigm?" (Mac Stephenson, Timothy Lehmann); "Open Learning: Educational Opportunity or Convenient Solution to Practical…

  9. AAHE Bulletin, 1996-97.

    ERIC Educational Resources Information Center

    Marchese, Theodore J., Ed.

    1997-01-01

    The 10 issues of this bulletin present reports, reviews and essays on issues concerning the advancement of higher education. Major articles include: "Learning, Teaching Technology"--an interview with Diana Laurillard of Britain's Open University; "Learning, Technology, and the Way We Work" (Russ Edgerton and Barbara Leigh Smith); "Implementing the…

  10. REVIEW OF REFLECTIONS IN BULLOUGH'S POND: ECONOMY AND ECOSYSTEM IN NEW ENGLAND

    EPA Science Inventory

    Reflections in Bullough's Pond is a fascinating and eye opening chronicle of New England from pre-European settlement to present times. Author Diana Muir uses the history of the pond in her backyard to individualize the story she tells. It's a powerful device that makes her arg...

  11. Women and Technical Professions. Leonardo da Vinci Series: Good Practices.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

    This document profiles programs for women in technical professions that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) Artemis and Diana (vocational guidance programs to help direct girls toward technology-related careers); (2) CEEWIT (an Internet-based information and…

  12. Education, Diversity, and Inclusion in Burmese Refugee Camps in Thailand

    ERIC Educational Resources Information Center

    Oh, Su-Ann; van der Stouwe, Marc

    2008-01-01

    This article explores the "two faces" model of education through which Kenneth Bush and Diana Saltarelli (2000) describe the positive and negative roles that education can play in situations of ethnic conflict. The authors apply it more narrowly to analyze the effect of inclusion and diversity in education in a conflict situation. In addition to…

  13. "Keeping Close and Spoiling" Revisited: Exploring the Significance of "Home" for Family Relationships and Educational Trajectories in a Marginalised Estate in Urban South Wales

    ERIC Educational Resources Information Center

    Mannay, Dawn

    2013-01-01

    This paper revisits Diana Leonard's seminal paper "Keeping close and spoiling in a south Wales town", by drawing on one mother and daughter case study. Leonard focused on geographical closeness and the strategies employed by parents to keep their children living at home, rather than sending them to university. In contrast, this…

  14. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). Media Ethics Division.

    ERIC Educational Resources Information Center

    2002

    The Media Ethics division of the proceedings contains the following 6 papers: "A Masochist's Teapot: Where to Put the Handle in Media Ethics" (Thomas W. Hickey); "Stalker-razzi and Sump-pump Hoses: The Role of the Media in the Death of Princess Diana" (Elizabeth Blanks Hindman); "The Promise and Peril of Anecdotes in News Coverage: An Ethical…

  15. Connecting the Private and the Public: Pregnancy, Exclusion, and the Expansion of Schooling in Africa

    ERIC Educational Resources Information Center

    Unterhalter, Elaine

    2013-01-01

    In a number of countries in Africa, young women who become pregnant are excluded from school. This article presents a critique of policy and practice in this area drawing partly on Diana Leonard's scholarship concerning the relational dynamic of gender, generation, social division, and household forms. Much of the policy prescription of large…

  16. The Learning Revolution. The Challenge of Information Technology in the Academy.

    ERIC Educational Resources Information Center

    Oblinger, Diana G., Ed.; Rush, Sean C., Ed.

    This book addresses the fundamental changes occurring in higher education, centering on productivity, quality, access, and competitiveness. The 15 chapters illustrate how public and private institutions are providing leadership for the higher education revolution. Chapters include: (1) "The Learning Revolution: (Diana G. Oblinger and Sean C.…

  17. The Teacher Trainer, A Practical Journal Mainly for Modern Language Teacher Trainers, 1997.

    ERIC Educational Resources Information Center

    Woodward, Tessa, Ed.

    1997-01-01

    The three issues of the journal on second language teacher education include these articles: "Monitoring and Evaluating the Production of Materials on a Large Scale Trainer Training Workshop" (R. Williams, Choong Kam Foong, Diana Lubelska); Sensory Channels in ESL Instruction" (Michael E. Rudder); "Using the In-Service Feedback Session To Promote…

  18. Evaluation Strategies and Techniques for Public Library Children's Services: A Sourcebook.

    ERIC Educational Resources Information Center

    Robbins, Jane; And Others

    The 28 papers in this sourcebook relate to the evaluation of children's services in public libraries: (1) "Introduction to Evaluation" (Jane Robbins and Douglas Zweizig); (2) "Research and Measurement in Library Services to Children" (Adele Fasick); (3) "Evaluating Children's Services" (Diana Young); (4) "What Is Good about Children's Library…

  19. 75 FR 69160 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... Sven Erik Farrell Douglas John Fay Mary Susan Standish Fernandez-Bianci Jorge Miguel Ferro Patricia... Rose Mary Andreen Clas Svante Joel Ang Diana Shu-Zhen Angelini Kevin Yang Aomori Miki Arakaki Shigeo.... Bozicevich Mario S. Brady Mary I. Brandl Marilyn Hester Bratsberg Bo Magnus Braziunas Darius Bree...

  20. Adult Education and Social Transformation: On Gramsci, Freire, and the Challenge of Comparing Comparisons. Essay Review.

    ERIC Educational Resources Information Center

    Schugurensky, Daniel

    2000-01-01

    Reviews three books that critique and compare the ideas of Gramsci and Freire: "Revolutionary Social Transformation: Democratic Hopes, Political Possibilities and Critical Education" (Paula Allman); "Radical Heroes: Gramsci, Freire and the Politics of Adult Education" (Diana Coben); and "Gramsci, Freire and Adult Education: Possibilities for…

  1. Impeccable Advice: Supporting Women Academics through Supervision and Mentoring

    ERIC Educational Resources Information Center

    Ali, Suki; Coate, Kelly

    2013-01-01

    At the time when Diana was writing " A Woman's Guide to Doctoral Studies" (2001), she was supervising a number of female doctoral students. She drew on some of their experiences in the writing of the book, and they in return benefited from the extensive insights she had about the politics of academic life that she portrays in her…

  2. Responses from the Field

    ERIC Educational Resources Information Center

    Fierro, Michael; Hankins, Diana

    2007-01-01

    In an effort to encourage dialogue and reflection on matters of common concern and interest, the journal staff invite responses on selected articles from other educators, who engage the text critically and offer some reflections about its utility and validity. This article offers responses from Michael Fierro and Diana Hankins on the article…

  3. Lying in Writing or the Vicissitudes of Testimony

    ERIC Educational Resources Information Center

    Hood, Carra Leah

    2005-01-01

    In this article, the author compares the arguments of Susan Swartzlander, Diana Pace, and Virginia Lee Stamler (1993) who note the contradiction between the "shockingly unprofessional" practice of asking students to write about their personal traumas in writing courses and the common occurrence of such assignments with Jeffrey Berman…

  4. Republic of Noise: The Loss of Solitude in Schools and Culture

    ERIC Educational Resources Information Center

    Senechal, Diana

    2011-01-01

    In "Republic of Noise," Diana Senechal confronts a culture that has come to depend on instant updates and communication at the expense of solitude. Where once it was common wisdom that the chatter of the present, about the present, could not always grasp the present, today we treat "real time" as though it were the only real time. Schools…

  5. Forging a New Direction: How UTEP Created Its Own Brand of Excellence

    ERIC Educational Resources Information Center

    Kuh, George D.; Natalicio, Diana S.

    2004-01-01

    The University of Texas at El Paso (UTEP) sits on the border of Mexico and the United States in the middle of the world's largest binational metropolitan region. For years, it struggled to compete with top-tier research institutions with far greater resources in a quest to become "Harvard on the Border." In the late 1980s, new president Diana S.…

  6. Proficiencies for Instruction Librarians: Is There Still a Disconnect between Professional Education and Professional Responsibilities?

    ERIC Educational Resources Information Center

    Westbrock, Theresa; Fabian, Sarah

    2010-01-01

    In 1993, based on the proficiencies for bibliographic instruction librarians (1986), Diana Shonrock and Craig Mulder investigated if and where librarians were acquiring these proficiencies. In 2007, ACRL approved a revised set of proficiencies: Proficiencies for Instruction Librarians and Coordinators. The authors recreated the 1993 study, using…

  7. The Rules of the Game: Women and the Leaderist Turn in Higher Education

    ERIC Educational Resources Information Center

    Morley, Louise

    2013-01-01

    This paper engages with Diana Leonard's writing on how gender is constituted in the academy. It offers an international review of feminist knowledge on how gender and power interact with leadership in higher education. It interrogates the "leaderist turn" or how leadership has developed into a popular descriptor and a dominant social and…

  8. Mussolini's Marriage and a Game in the Playground: Using Analogy to Help Pupils Understand the Past

    ERIC Educational Resources Information Center

    Laffin, Diana; Wilson, Maggie

    2005-01-01

    Diana Laffin and Maggie Wilson want their pupils to connect with people in the past and to experience some of their emotions. The emotional factor is a difficult one in history, both for pupils and professional historians. When studying Eden's actions at Suez, for example, what we lack is a proper insight into the immediate pressures he faced and…

  9. Analysis of Parental Involvement and Self-Esteem on Secondary School Students in Kieni West Sub-County, Nyeri County, Kenya

    ERIC Educational Resources Information Center

    Wairimu, Mburu Josephine; Macharia, Susan M.; Muiru, Ann

    2016-01-01

    This study investigated the relationship between parental involvement and the self-esteem among adolescents in secondary school students in Kieni West District in Nyeri County. It was guided by Self Determination Theory (SDT) by James William and Baumrind Theory of Parenting Styles by Diana Blumberg Baumrind. Some of the gaps identified in the…

  10. Missouri Assessment Program (MAP), Spring 2000: Intermediate Communication Arts, Released Items, Grade 7.

    ERIC Educational Resources Information Center

    Missouri State Dept. of Elementary and Secondary Education, Jefferson City.

    This document deals with testing in intermediate communication arts for seventh graders in Missouri public schools. The document contains the following items from the Session 1 Test Booklet: "Swimming in Snow" (Diana C. Conway) (Items 1, 2, and 5); "Discovery" (Marion Dane Bauer) (Item 13); writing prompt; and a writer's checklist. It also…

  11. Marr: Magpie or Marsh Harrier? The Quest for the Common Characteristics of the Genus "Historian" with 16- to 19-Year-Olds

    ERIC Educational Resources Information Center

    Laffin, Diana

    2012-01-01

    Diana Laffin writes about historical language and explores how understanding different historians' use of language can help sixth form students refine and deepen both their understanding of the discipline of history and their abilities to practise the discipline in their own writing. What does close study of the textual habits and practices of…

  12. How Schools Can Support Children Who Experience Loss and Death

    ERIC Educational Resources Information Center

    Holland, John

    2008-01-01

    Scenes of public grieving such as followed the death of Princess Diana bear little resemblance to the "taboo" status of death and bereavement at an individual level. For schools and the support services with whom they work, responding to pupils' experiences of loss and death, especially of parents, is challenging. This paper draws on research and…

  13. Precious Knowledge: Teaching Solidarity with Tucson

    ERIC Educational Resources Information Center

    Carberry, Devin

    2013-01-01

    The author's class has been invited to speak on NPR's "Call-In-Radio" and two of her students, Omar and Diana, were elected to be their spokespeople regarding HB 2281, Arizona's controversial ethnic studies ban. Omar stressed that he and his classmates are engaged by this topic because they see what's happening in Arizona is wrong--that they are…

  14. A Simultaneous Quantum Secure Direct Communication Scheme between the Central Party and Other M Parties

    NASA Astrophysics Data System (ADS)

    Gao, Ting; Yan, Feng-Li; Wang, Zhi-Xi

    2005-10-01

    We propose a simultaneous quantum secure direct communication scheme between one party and other three parties via four-particle GHZ states and swapping quantum entanglement. In the scheme, three spatially separated senders, Alice, Bob and Charlie, transmit their secret messages to a remote receiver Diana by performing a series of local operations on their respective particles according to the quadripartite stipulation. From Alice, Bob, Charlie and Diana's Bell measurement results, Diana can infer the secret messages. If a perfect quantum channel is used, the secret messages are faithfully transmitted from Alice, Bob and Charlie to Diana via initially shared pairs of four-particle GHZ states without revealing any information to a potential eavesdropper. As there is no transmission of the qubits carrying the secret message in the public channel, it is completely secure for the direct secret communication. This scheme can be considered as a network of communication parties where each party wants to communicate secretly with a central party or server.

  15. DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

    EPA Science Inventory

    DESIGNING SULFATE-REDUCING BACTERIA FIELD-BIOREACTORS USING THE BEST MODEL

    Marek H. Zaluski1,3, Brian T. Park1, Diana R. Bless2

    1 MSE Technology Applications; 200 Technology Way, Butte, Montana 59701, USA
    2 U.S. EPA, Office of Research and Development, Cincinna...

  16. Rachel's Challenge: A Moral Compass for Character Education

    ERIC Educational Resources Information Center

    Hollingshead, Barbara; Crump, Christi; Eddy, Rochelle; Rowe, Dina

    2009-01-01

    Though American life in 1923 was significantly different than the present day, authors John Dewey and Diana Brannon share similar concerns about character. Historically, educators as far back as the 1800s have felt an obligation to the community to transcend the primary purpose for schooling by including character education in their curricula.…

  17. On Common Ground: Prominent Women Talk about Work & Family.

    ERIC Educational Resources Information Center

    Zuckerman, Diana, Ed.

    This publication presents interviews with 11 prominent women, representing different backgrounds, philosophies, and life experiences, in which they speak about their own experiences with work and family issues. The introduction, "On Common Ground: Prominent Women Talk about Work & Family" (Diana Zuckerman), provides an overview. The 11 interviews…

  18. Introduction to "Multicultural Voices: Peer Tutoring and Critical Reflection in the Writing Center"

    ERIC Educational Resources Information Center

    Grimm, Nancy Maloney

    2010-01-01

    In 1991 when Diana George, Ed Lotto, and the author were publishing their first issue as "WCJ" editors, this multivoiced essay struck her as a prime example of their editorial belief that writing centers could be "agents of change in the academy." As Gail Okawa and Tom Fox observe, "Most universities are inhospitable to more democratic definitions…

  19. Using Group-Based Learning in Higher Education. Teaching and Learning in Higher Education Series.

    ERIC Educational Resources Information Center

    Thorley, Lin, Ed.; Gregory, Roy, Ed.

    The 26 papers in this collection from a British conference first provide an overview of group-based learning in higher education, offer a range of examples, and identify issues and trends. Chapters include: (1) "Introduction" (Roy Gregory and Lin Thorley); (2) "An Overview from Higher Education" (Diana M. R. Tribe); (3) "The UPshot Programme:…

  20. Otherness through Elves: Into Elfland and Beyond

    ERIC Educational Resources Information Center

    Yamazaki, Akiko

    2008-01-01

    This article examines three novels which use stories of elves--especially the ballad "Tam Lin"--as pre-texts, and contemplates how they explore the issue of Otherness. The three novels are "The Sterkarm Handshake" by Susan Price, "Cold Tom" by Sally Prue, and "Fire and Hemlock" by Diana Wynne Jones. Although the novels seem to be about elves as…

  1. Teaching for Tomorrow: Integrating LRE and the Social Studies. Bar/School Partnership Programs.

    ERIC Educational Resources Information Center

    Wolowiec, Jack, Ed.

    This collection of four short articles presents teaching strategies to enrich the social studies curriculum and promote students' sense of citizenship. Diana Hess outlines how cooperative learning stimulates the skills necessary for effective participation in a democratic society. By taking an active role in their own education and respecting the…

  2. A Sacrificial Lam: A Divided School Board, a Beleaguered Superintendent, and an Urgent Need to Improve Student Achievement

    ERIC Educational Resources Information Center

    Fossey, Richard

    2011-01-01

    This case describes the confrontational relationship between four trustees on the San Antonio School Board and the San Antonio School District's superintendent Diana Lam, a nationally recognized school reformer, who came to San Antonio in 1994. The case includes a dramatic board meeting where a closely divided board meets to buy out Lam's…

  3. 77 FR 60477 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... collect soil samples and take permafrost measurements. These sites are specifically targeted because of... 31, 2012. Permit Application: 2013-023 Applicant: Diana H. Wall, Natural Resource Ecology Laboratory... soils and associated terrestrial invertebrates found in ornithogenic soils from penguin rookeries....

  4. Rethinking "Harmonious Parenting" Using a Three-Factor Discipline Model

    ERIC Educational Resources Information Center

    Greenspan, Stephen

    2006-01-01

    Diana Baumrind's typology of parenting is based on a two-factor model of "control" and "warmth". Her recommended discipline style, labeled "authoritative parenting", was constructed by taking high scores on these two factors. A problem with authoritative parenting is that it does not allow for flexible and differentiated responses to discipline…

  5. Making Matter Making Us: Thinking with Grosz to Find Freedom in New Feminist Materialisms

    ERIC Educational Resources Information Center

    Jackson, Alecia Youngblood

    2013-01-01

    In this paper, I offer a very close reading of Grosz [2010. "Feminism, Materialism, and Freedom." In "New Materialisms: Ontology, Agency, and Politics," edited by Diana Coole and Samantha Frost, 139-157. Durham, NC: Duke University Press] thinking with Bergson in order to re-conceptualise freedom, matter, and the subject in new…

  6. Mini-Portfolio on Math and Science.

    ERIC Educational Resources Information Center

    Teaching PreK-8, 1996

    1996-01-01

    Presents six articles dealing with math and science education: "Sneaker Geometry" (Jack George), "Fairs with a Flair" (Diane McCarty), "Generating Excitement with Math Projects" (Jeffrey Kostecky and Louis Roe), "Playing with Numbers" (Diana Smith), "When Student Teachers Want to Do Hands-On Science" (Betsy Feldkamp-Price), and "Science ala Carte"…

  7. You Are Embarked: How a Philosophy Curriculum Took Shape and Took Off

    ERIC Educational Resources Information Center

    Senechal, Diana

    2015-01-01

    Diana Senechal teaches philosophy at Columbia Secondary School for Math, Science, and Engineering in New York City; in addition, she serves on the faculty of the Sue Rose Summer Institute for Teachers at the Dallas Institute of Humanities and Culture. In this article she states that if someone had told her five years ago that she would be a high…

  8. Technology, Education, and the Changing Nature of Resistance.

    ERIC Educational Resources Information Center

    Rickard, Wendy

    1999-01-01

    Discusses information technology in higher education. Includes comments from Educom Medal Awards winners honored for contributions made to improving undergraduate education through information technology: Paul Velleman, Cornell; Diana Eck, Harvard; Richard Larson, Stony Brook; David Fulker, University Corporation; and Stephen Ressler, Military…

  9. 76 FR 22075 - Divide Ranger District, Rio Grande National Forest; CO; Black Mesa Vegetation Management Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Vegetation Management Project AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare an... Mesa Vegetation Management Project Public Comment. FOR FURTHER INFORMATION CONTACT: Diana McGinn at 719... for Action The purpose and need for the Black Mesa Vegetation Management Project is move...

  10. 78 FR 45495 - Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ..., 2013. Andrea Jones, District Ranger. [FR Doc. 2013-17968 Filed 07/26/2013 at 8:45 a.m.; Publication... Forest Service Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation... Cumbres Vegetation Management Project. FOR FURTHER INFORMATION CONTACT: Diana McGinn at 719-852-6241...

  11. Los biocombustibles y el futuro

    NASA Video Gallery

    ¿Cómo podremos utilizar los biocombustibles en el futuro? La ingeniera aeroespacial de la NASA, Diana Centeno Gómez nos explica el futuro de los biocombustibles y cómo un día podrías trabajar con d...

  12. [Anesthesiological systems "Polinarkon-Vita" with microprocessor for artificial lung ventilation apparatuses and monitoring].

    PubMed

    Trushin, A I; Uliakov, G I; Reĭderman, E N

    2005-01-01

    The anesthesiological systems Polinarkon-Vita for adults and children are described. These systems were developed at VNIIMP-VITA, Ltd. on the basis of basic model of the anesthesiological system Polinarkon-E-Vita. The following new important units of the fifth generation apparatuses for inhalation anesthesia (IA) are described: Anestezist-4 monocomponent evaporator for liquid anesthetics (enfluran and isofluran); Diana, Diana-Det, and Elan-NR apparatuses for mechanical lung ventilation (MLV); dosimeters of medical gases, etc. These systems implement monitoring of vitally important functions of patient and parameters of IN and MLV. The anesthesiological systems Polinarkon-Vita are recommended for medical practice and commercially available from VNIIMP-VITA, Ltd. as small lots.

  13. Application of PIXE to the study of Renaissance style enamelled gold jewelry

    NASA Astrophysics Data System (ADS)

    Weldon, M.; Carlson, J.; Reedy, S.; Swann, C. P.

    1996-04-01

    This study examines and compares three pieces of Renaissance style gold and enamelled jewelry owned by the Walters Art Gallery, Baltimore, MD, USA. These are a 16th century Hat Badge of Adam and Eve, a 19th century Fortitude Pendant and a Diana Pendant presumed to be of the 16th century (The Walters Art Gallery, Jewelry, Ancient to Modern (Viking, New York, 1979)), Ref. [1]. PIXE spectroscopy was applied to examine the elemental composition of the gold and of the enamels. Compositional differences, including the use of post-Renaissance colorants, were found between the enamels in separate regions of each of the three pieces. The modern colorant, chromium, was, in fact, found in all of the pieces and uranium was found in only the Diana Pendant. There are some differences in the gold purity of the three objects; there are significant differences in the solders used even within one object, the Fortitude Pendant.

  14. PREFACE: Conference Committee

    NASA Astrophysics Data System (ADS)

    2016-02-01

    ORGANISING COMMITTEE: Alexander Petrov - Chairman, Kiril Blagoev - Vice-Chairman, Margarita Grozeva - Scientific secretary, Kostadinka Gesheva, Anna Szekeres, Hassan Chamati, Diana Nesheva, Peter Rafailov, Yordan Marinov, Emilia Dimova, Tatyana Ivanova, Radostina Kamburova, Ekaterina Iordanova, Julia Genova, Alexander Donkov, Emilia Vlaikova SCIENTIFIC COMMITTEE: Alexander Petrov, Bulgaria; Nikola Sabotinov, Bulgaria; Kiril Blagoev, Bulgaria; Nicholay Tonchev, Bulgaria; Hassan Chamati, Bulgaria; Marin Gospodinov, Bulgaria; Peter Rafailov, Bulgaria; Emil Vlakhov, Bulgaria; Kostadinka Gesheva, Bulgaria; Anna Szekeres, Bulgaria; Diana Nesheva, Bulgaria; Albena Paskaleva, Bulgaria; Tatyana Ivanova, Bulgaria; Alexander Dreischuh, Bulgaria; Evgenia Valcheva, Bulgaria; Miglena Nikolaeva-Dimitrova, Bulgaria; Sanka Gateva, Bulgaria; Frank Hamelmann, Germany; Nicola Scaramuzza, Italy; G.M.W. Kroesen, Netherlands; Jan van Dijk Netherlands; Andrzej Szewczyk, Poland; Henryk Szymczak, Poland; Krzistof Rogacki, Poland; Ion Mihailescu, Romania; Claes-Goran Granqvist, Sweden; Mikael Jonsson, Sweden; Andrew Livingston, UK; Ludmila Peeva, UK

  15. Population dynamics of calyptrate Diptera (Muscidae and Sarcophagidae) at the Rio-Zoo Foundation, Rio de Janeiro, RJ, Brazil.

    PubMed

    Oliveira, V C; D'Almeida, J M; Paes, M J; Sanavria, A

    2002-05-01

    Twenty-seven species of calyptrate muscoids (Muscidae and Sarcophagidae) were collected from December 1993 to November 1994 with wind oriented traps (W.O.T.) baited with decomposing beef liver at the Rio de Janeiro Zoo. The most abundant species found were Musca domestica (57.84%), Peckia chrysostoma (28.16%), Ophyra aenescens (17.11%), Oxysarcodexia thornax (17.82%), Synthesiomyia nudiseta (13.05%), and Oxysarcodexia diana (14.52%).

  16. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Cancer.gov

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria Kaltcheva, Wojciech Kasprzak, Balamurugan Kuppusamy, James Lautenberger, George Lountos, Megan Mounts, Uma Mudunuri, Martha Sklavos, Gloriana Shelton, Alex Sorum, and Shea Wright.

  17. Development of Analyzers for Two-dimensional Photoelectron Spectroscopy and Their Applications

    NASA Astrophysics Data System (ADS)

    Daimon, Hiroshi; Matsui, Fumihiko

    Development of analyzers for two-dimensional photoelectron spectroscopy and their applications are summarized. Newest high-energy-resolution display-type spherical mirror analyzer (DIANA) is explained in detail. Scientific achievements specific to two-dimensional spectroscopy are shown: such as photoelectron diffraction, photoelectron holography, circularly-polarized-light photoelectron diffraction, stereo-photograph of atomic arrangement, three-dimensional band structure, atomic orbital analysis, photoemission structure factor, orbital angular momentum analysis for valence band electrons. Some prospects for future are described.

  18. What All Teachers Hope for

    ERIC Educational Resources Information Center

    Nye, Ken

    2005-01-01

    In this article, the author relates how he had touched the life of one of his troubled students. He relates how he had helped Diana, his student, make her life a little smoother after her mother's suicide. He relates that this is the very reason why he had loved teaching for most of his 40-year career as an educator. The author states that the…

  19. [Effect of erythrocyte preserved for different lengths of time on anti-D antibody identification with three blood matching tests].

    PubMed

    Xiao, Rui-Qing; Lin, Wu-Cun; Xu, Dan; Zeng, Jie; Wu, Jian-Jun; Zhao, Shu-Ming

    2003-10-01

    The specificity of the antigens and length of preservation time of erythrocytes are the interfering factors in blood group serological tests. In order to clarify the influence of preservation time of erythrocytes on the blood matching test, the titers of anti-D antibody were detected with papain method, BioVue cross matching card and DianaGel cross matching card in 7 series of panel red blood cells preserved for various length of time (0 to 9 months). The results showed that the titer of micro-column gel test (DianaGel card) was one tube higher than that of column agglutinating test (BioVue card). The titer of erythrocytes preserved for 9 months was as high as 256 tested by DianaGel card, but it was only 2 by papain method in the same anti-serum. It is suggested that there was no obvious difference between the results of micro-column gel test and column agglutinating test, and titer of papain method was the lowest. PMID:14575550

  20. Locations and attributes of wind turbines in Colorado, 2011

    USGS Publications Warehouse

    Carr, Natasha B.; Diffendorfer, James E.; Fancher, Tammy; Hawkins, Sarah J.; Latysh, Natalie; Leib, Kenneth J.; Matherne, Anne Marie

    2013-01-01

    This dataset represents an update to U.S. Geological Survey Data Series 597. Locations and attributes of wind turbines in Colorado, 2009 (available at http://pubs.usgs.gov/ds/597/). This updated Colorado wind turbine Data Series provides geospatial data for all 1,204 wind turbines established within the State of Colorado as of September 2011, an increase of 297 wind turbines from 2009. Attributes specific to each turbine include: turbine location, manufacturer and model, rotor diameter, hub height, rotor height, potential megawatt output, land ownership, county, and development status of the wind turbine. Wind energy facility data for each turbine include: facility name, facility power capacity, number of turbines associated with each facility to date, facility developer, facility ownership, and year the facility went online. The locations of turbines are derived from 1-meter true-color aerial photographs produced by the National Agriculture Imagery Program (NAIP); the photographs have a positional accuracy of about ±5 meters. Locations of turbines constructed during or prior to August 2009 are based on August 2009 NAIP imagery and turbine locations constructed after August 2009 were based on September 2011 NAIP imagery. The location of turbines under construction during September 2011 likely will be less accurate than the location of existing turbines. This data series contributes to an Online Interactive Energy Atlas developed by the U.S. Geological Survey (http://my.usgs.gov/eerma/). The Energy Atlas synthesizes data on existing and potential energy development in Colorado and New Mexico and includes additional natural resource data layers. This information may be used by decisionmakers to evaluate and compare the potential benefits and tradeoffs associated with different energy development strategies or scenarios. Interactive maps, downloadable data layers, comprehensive metadata, and decision-support tools also are included in the Energy Atlas. The format of

  1. Locations and attributes of wind turbines in New Mexico, 2011

    USGS Publications Warehouse

    Carr, Natasha B.; Diffendorfer, James B.; Fancher, Tammy; Hawkins, Sarah J.; Latysh, Natalie; Leib, Kenneth J.; Matherne, Anne Marie

    2013-01-01

    This dataset represents an update to U.S. Geological Survey Data Series 596. Locations and attributes of wind turbines in New Mexico, 2009 (available at http://pubs.usgs.gov/ds/596/).This updated New Mexico wind turbine Data Series provides geospatial data for all 562 wind turbines established within the State of New Mexico as of June 2011, an increase of 155 wind turbines from 2009. Attributes specific to each turbine include: turbine location, manufacturer and model, rotor diameter, hub height, rotor height, potential megawatt output, land ownership, county, and development status of wind turbine. Wind energy facility data for each turbine include: facility name, facility power capacity, number of turbines associated with each facility to date, facility developer, facility ownership, and year the facility went online. The locations of turbines are derived from 1-meter true-color aerial photographs produced by the National Agriculture Imagery Program (NAIP); the photographs have a positional accuracy of about ±5 meters. The locations of turbines constructed during or prior to August 2009 are based on August 2009 NAIP imagery and turbine locations constructed after August 2009 were based June 2011 NAIP imagery. The location of turbines under construction during June 2011 likely will be less accurate than the location of existing turbines. This data series contributes to an Online Interactive Energy Atlas developed by the U.S. Geological Survey (http://my.usgs.gov/eerma/). The Energy Atlas synthesizes data on existing and potential energy development in Colorado and New Mexico and includes additional natural resource data layers. This information may be used by decisionmakers to evaluate and compare the potential benefits and tradeoffs associated with different energy development strategies or scenarios. Interactive maps, downloadable data layers, comprehensive metadata, and decision-support tools also are included in the Energy Atlas. The format of the Energy

  2. Two decision-support tools for assessing the potential effects of energy development on hydrologic resources as part of the Energy and Environment in the Rocky Mountain Area interactive energy atlas

    USGS Publications Warehouse

    Linard, Joshua I.; Matherne, Anne Marie; Leib, Kenneth J.; Carr, Natasha B.; Diffendorfer, James E.; Hawkins, Sarah J.; Latysh, Natalie; Ignizio, Drew A.; Babel, Nils C.

    2014-01-01

    The U.S. Geological Survey project—Energy and Environment in the Rocky Mountain Area (EERMA)—has developed a set of virtual tools in the form of an online interactive energy atlas for Colorado and New Mexico to facilitate access to geospatial data related to energy resources, energy infrastructure, and natural resources that may be affected by energy development. The interactive energy atlas currently (2014) consists of three components: (1) a series of interactive maps; (2) downloadable geospatial datasets; and (3) decison-support tools, including two maps related to hydrologic resources discussed in this report. The hydrologic-resource maps can be used to examine the potential effects of energy development on hydrologic resources with respect to (1) groundwater vulnerability, by using the depth to water, recharge, aquifer media, soil media, topography, impact of the vadose zone, and hydraulic conductivity of the aquifer (DRASTIC) model, and (2) landscape erosion potential, by using the revised universal soil loss equation (RUSLE). The DRASTIC aquifer vulnerability index value for the two-State area ranges from 48 to 199. Higher values, indicating greater relative aquifer vulnerability, are centered in south-central Colorado, areas in southeastern New Mexico, and along riparian corridors in both States—all areas where the water table is relatively close to the land surface and the aquifer is more susceptible to surface influences. As calculated by the RUSLE model, potential mean annual erosion, as soil loss in units of tons per acre per year, ranges from 0 to 12,576 over the two-State area. The RUSLE model calculated low erosion potential over most of Colorado and New Mexico, with predictions of highest erosion potential largely confined to areas of mountains or escarpments. An example is presented of how a fully interactive RUSLE model could be further used as a decision-support tool to evaluate the potential hydrologic effects of energy development on a

  3. Retrograde deformation within the Carthage-Colton Zone as recorded by fluid inclusions and feldspar compositions: tectonic implications for the southern Grenville Province

    NASA Astrophysics Data System (ADS)

    Lamb, William M.

    1993-09-01

    The Carthage-Colton Zone (CCZ), located in the northwestern portion of the Proterozoic Adirondack terrane, forms the boundary between the Adirondack lowlands and highlands and is characterized by textures indicative of ductile deformation. Samples from three rock types have been collected from this zone: (1) pyroxene bearing syenite gneisses of the Diana igneous complex; (2) paragneiss samples from near the northwestern boundary of the Diana complex; (3) a quartz-rich metasediment. Feldspar geothermometry performed on the Diana metasyenites shows that porphyroclasts are relict igneous grains that formed at T≈900° C, while dynamic recrystallization occurred at temperatures as low as 470 to 550° C as shown by the compositions of feldspar neoblasts. All samples examined in this study from the CCZ contain a suite of CO2-rich fluid inclusions that are distinctive both texturally and in their microthermometric behavior (Th=-27.7 to-7.1° C) as compared to CO2-rich Adirondack fluid inclusions that do not lie within this zone (Th=-45.9 to +31.0° C). The results from fluid inclusion microthermometry and feldspar geothermometry restrict the conditions of dynamic recrystallization to temperatures and pressures of 400 to 550° C and 3 to 5 kbar. The retrograde pressure-temperature path must pass through these conditions. Similar fluid inclusion results have been obtained from the Parry Sound Shear Zone (PSSZ) which is a Grenvillian shear zone that is located in Southern Ontario (Lamb and Moecher 1992). However, the inferred retrograde P-T paths for these two areas, the CCZ and the PSSZ, are different and this difference may be a result of late deformation along shear zones that are located between the two areas.

  4. Shimoda 1854: Historical Consequences of a Natural Disaster

    NASA Astrophysics Data System (ADS)

    Petrova, A.

    2012-04-01

    At the end of 1854 - beginning of 1855 Japan was struck by a series of powerful earthquakes known as the Ansei Great Earthquakes. The first one, Ansei-Tōkai Quake, occurred on 23 December, 1854. It had a magnitude of 8.4; the epicenter ranged from the centre of Suruga Bay to the south-east into the ocean. It was followed by the Ansei-Nankai Quake on 24 December. The earthquakes with the following tsunami caused a huge damage in several regions of Japan: more than 20,000 buildings were destroyed, about 30,000 casualties caused. This natural disaster was witnessed by a Russian diplomatic mission led by admiral Yevfimy Putyatin. His flagship, frigate Diana, stayed at Shimoda, and Putyatin was conducting long and difficult negotiations trying to convince Japan of signing a commercial treaty with Russia, when Shimoda was hit by the tsunami. Several members of the mission described their impressions in their memoirs. The city was almost completely destroyed (only 16 houses survived the disaster). Diana was also badly damaged and sank in a storm while sailing to Heda for repairs. It was decided to build a new ship for the Russian mission. Works were carried out in Heda with the help of plans salvaged from the Diana, and required a cooperation of Russian sailors and Japanese carpenters. In about two months a two-masted schooner was built, which was christened Heda in honour of the city that helped with its construction. The Heda was the first western-style ship built in Japan, and thus can be called a "grandfather" of a Japanese oceanic navy. On 26 January, 1855 the Russian-Japanese negotiations were successfully concluded, and the Treaty of Shimoda was signed, marking the start of official relations between Russia and Japan. Thus a terrible natural disaster framed one of the most vivid pages in history of the Japanese-Russian relationship.

  5. Venus - Volcanism and rift formation in Beta Regio

    NASA Astrophysics Data System (ADS)

    Campbell, D. B.; Head, J. W.; Harmon, J. K.; Hine, A. A.

    1984-10-01

    A new high-resolution radar image of Beta Regio, a Venus highland area, confirms the presence of a major tectonic rift system and associated volcanic activity. The lack of identifiable impact craters, together with the apparent superposition of the Theia Mons volcanic structure on the rift system, suggest that at least some of the volcanic activity occurred in relatively recent geologic time. The presence of topographically similar highland areas elsewhere on Venus (Aphrodite Terra, Dali Chasma, and Diana Chasma) suggests that rifting and volcanism are significant processes on Venus.

  6. [New artificial lung respiration apparatuses for anesthesia and design of gas flow commutators].

    PubMed

    Reĭderman, E N; Sterlin, Iu G; Trushin, A I; Maiakov, A A; Nemirovskiĭ, S B; Tsvik, A I

    2005-01-01

    The principles of action of new anesthetic devices and apparatuses for mechanical lung ventilation (MLV) including alternate-flow inhalation generators designed in recent time in VNIIMP-VITA, Ltd. are considered. According to the type of drive, these apparatuses fall into groups of devices with pneumatic drive (Diana) and electric drive (Elan). New technological approaches to design of gas flow commutators for pneumatic drive and respiratory contours of MLV apparatuses are discussed. The design of a new source of stable pneumatic signals providing reliable operation of the control valves of the inhalation and exhalation contours of electrically driven apparatuses. This source allows necessary MLV modes to be implemented during anesthesia. PMID:16491662

  7. The gifts of silence and solitude.

    PubMed

    Schmidt Bunkers, Sandra

    2008-01-01

    In this column the author describes the importance of finding silence and solitude amid the noise and technology present today in the teaching-learning academy. Three gifts of silence and solitude are identified: the gift of comforting aloneness, the gift of vision for new horizons, and the gift of a sense of freedom. A humanbecoming perspective is used to explore the implications of these gifts. This column introduces a column by Diana Vander Woude describing her teaching-learning experience in leadership focusing on silence and solitude. PMID:18096981

  8. Interpretation of the Theta+ as an isotensor pentaquark with weakly decaying partners

    SciTech Connect

    Simon Capstick; Philip R. Page; Winston Roberts

    2003-09-25

    The {Theta}{sup +}(1540), recently observed at LEPS, DIANA and CLAS, is hypothesized to be an isotensor resonance. This implies the existence of a multiplet where the {Theta}{sup ++}, {Theta}{sup +} and {Theta}{sup 0} have isospin-violating strong decays, and the {Theta}{sup +++} and {Theta}{sup -} have weak decays and so are long-lived. Production mechanisms for these states are discussed. The J{sup P} assignment of the {Theta} is most likely 1/2{sup -} or 3/2{sup -} or 5/2{sup -}.

  9. Reflectional symmetry breaking of the separated flow over 3D bluff bodies

    NASA Astrophysics Data System (ADS)

    Grandemange, Mathieu; Gohlke, Marc; Cadot, Olivier

    2012-11-01

    The first experimental observation of a permanent reflectional symmetry breaking (RSB) is reported for a laminar three-dimensional wake. Based on flow visualizations, a first bifurcation from the trivial steady symmetric state to a steady RSB state is characterized at Re = 340. The RSB state becomes unsteady after a second bifurcation at Re = 410. It is found that this RSB regime is persistent at large Reynolds numbers and responsible for a bi-stable turbulent wake. The authors are indebted to R. Godoy Diana, V. Raspa and B. Thiria from ESPCI (Paris, France) for lending their low speed hydrodynamics tunnel.

  10. Formation of a narrow baryon resonance with positive strangeness in K + collisions with Xe nuclei

    NASA Astrophysics Data System (ADS)

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tumanov, G. K.; Verebryusov, V. S.

    2010-07-01

    The data on the charge-exchange reaction K +Xe → K 0 pXe', obtained with the bubble chamber DIANA, are reanalyzed using increased statistics and updated selections. Our previous evidence for formation of a narrow pK 0 resonance with mass near 1538 MeV is confirmed. The statistical significance of the signal reaches some 8 (6) standard deviations when estimated as {S {sqrt B ( {{S {/ {sqrt {B + S} }}} )}} . The mass and intrinsic width of the Θ+ baryon are measured as m = 1538 ± 2 MeV and Γ = 0.39 ± 0.10 MeV.

  11. The narrow pentaquark

    NASA Astrophysics Data System (ADS)

    Diakonov, Dmitri

    2007-02-01

    The experimental status of the pentaquark searches is briefly reviewed. Recent null results by the CLAS collaboration are commented, and new strong evidence of a very narrow Θ+ resonance by the DIANA collaboration is presented. On the theory side, I revisit the argument against the existence of the pentaquark — that of Callan and Klebanov — and show that actually a strong resonance is predicted in that approach, however its width is grossly overestimated. A recent calculation gives 2 MeV for the pentaquark width, and this number is probably still an upper bound.

  12. Inevitable Pentaquark

    NASA Astrophysics Data System (ADS)

    Diakonov, D.

    The experimental status of the pentaquark searches is briefly reviewed.Recent null results by the CLAS collaboration are commented, and new strong evidence of a very narrow Θ^+ resonance by the DIANA collaboration is presented. On the theory side, we revisit the argument against the existence of the pentaquark --- that of Callan and Klebanov --- and show that actually a strong resonance is predicted in that approach, however its width is grossly overestimated. A recent calculation gives 2 MeV for the pentaquark width, and this number is probably still an upper bound.

  13. A Electronic Voting Scheme Achieved by Using Quantum Proxy Signature

    NASA Astrophysics Data System (ADS)

    Cao, Hai-Jing; Ding, Li-Yuan; Yu, Yao-Feng; Li, Peng-Fei

    2016-09-01

    In this paper, we propose a new electronic voting scheme using Bell entangled states as quantum channels. This scheme is based on quantum proxy signature. The voter Alice, vote management center Bob, teller Charlie and scrutineer Diana only perform single particle measurement to realize the electronic voting process. So the scheme reduces the technical difficulty and increases operation efficiency. It can be easily realized. We use quantum key distribution and one-time pad to guarantee its unconditional security. The scheme uses the physical characteristics of quantum mechanics to guarantee its anonymity, verifiability, unforgetability and undeniability.

  14. Classification of Murine Pulmonary Tumors —

    Cancer.gov

    This WEB site contains a digital atlas of virtual histological slides with representative mouse and human pulmonary proliferative lesions. It complements the paper "Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium" by Alexander Yu. Nikitin, Ana Alcaraz, Miriam R. Anver, Roderick T. Bronson, Robert D. Cardiff, Darlene Dixon, Armando E. Fraire, Edward W. Gabrielson, William T. Gunning, Diana C. Haines, Matthew H. Kaufman, R. Ilona Linnoila, Robert R. Maronpot, Alan S. Rabson, Robert L. Reddick, Sabine Rehm, Nora Rozengurt, Hildegard M. Schuller, Elena N. Shmidt, William D. Travis, Jerrold M. Ward and Tyler Jacks published in Cancer Research 64: 2307-2316, 2004

  15. Collaboration on SEP Missions to the Moon and Small Bodies

    NASA Technical Reports Server (NTRS)

    Pieters, C. M.

    1997-01-01

    In response to the Discovery announcement of opportunity a team consisting of TRW Lewis Research Center, JPL and UCLA with scientific co-investigators from government and University laboratories have proposed to fly the first planetary solar electric propulsion (SEP) mission. Diana is designed to carry an X-ray and gamma ray spectrometer, and imaging spectrometer, a framing camera, a laser altimer an ion spectrometer and a magnetometer. In order to obtain lunar gravity data from the far side of the moon a relay satellite is placed into high polar orbit about the moon to relay the Doppler-shifted telemetry to Earth. Diana will spend two months in a 700 km polar orbit obtaining mineralogical data from a full spectral map of the lunar surface, and then spend a year in a 100 km (or below) polar orbit mapping the lunar elemental composition, its topography, gravity field, ions from its atmosphere and its permanent and induced magnetic fields. After the low altitude mapping phase the ion thrusters propel the spacecraft out of the lunar sphere of influence and onto a heloioscentric trajectory to rendezvous with dormant comet Wilson-Harrington. The ground truth provided by the returned lunar samples to validate the remote sensing instruments for lunar studies will also serve to validate the Wilson-Harrington observations since the same instruments will be used at both bodies.

  16. X-ray Radiative Transfer in Protoplanetary Disks with ProDiMo

    NASA Astrophysics Data System (ADS)

    Rab, Christian; Woitke, Peter; Güdel, Manuel; Min, Michiel; Diana Team

    2013-07-01

    X-ray emission is a common property of YSOs. T Tauri stars show X-ray luminosities up to 10^32 erg/s but also Herbig Ae/Be stars can have moderate X-ray emission in the range of 10^28 to 10^31 erg/s. We want to investigate the impact of X-ray radiation on the thermal and chemical structure of protoplanetary discs around these YSOs. Therefore we have added a new X-ray Radiative Transfer module to the radiation thermo-chemical code ProDiMo (Protoplanetary Disc Modeling) extending the existing implementation of X-ray chemistry implemented by Aresu et al. This new module considers gas and dust opacities (including scattering) and a possible X-ray background field. Further we added a new set of FUV - photoreactions to the X-ray chemistry module of ProDiMo as fast electrons created in X-ray ionisation can produce a significant secondary FUV radiation field by exciting atomic or molecular hydrogen. We discuss the importance of these processes on the thermal and chemical structure of the protoplanetary disc, and present them on the basis of a typical T Tauri disc model. This work is performed in the context of the EU FP7-project DIANA (www.diana-project.com).

  17. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d'Ivoire.

    PubMed

    Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N'goran, Eliezer Kouakou; Candolfi, Ermanno

    2015-01-01

    Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d'Ivoire's Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. PMID:25619957

  18. Diversity and prevalence of gastrointestinal parasites in seven non-human primates of the Taï National Park, Côte d’Ivoire

    PubMed Central

    Kouassi, Roland Yao Wa; McGraw, Scott William; Yao, Patrick Kouassi; Abou-Bacar, Ahmed; Brunet, Julie; Pesson, Bernard; Bonfoh, Bassirou; N’goran, Eliezer Kouakou; Candolfi, Ermanno

    2015-01-01

    Parasites and infectious diseases are well-known threats to primate populations. The main objective of this study was to provide baseline data on fecal parasites in the cercopithecid monkeys inhabiting Côte d’Ivoire’s Taï National Park. Seven of eight cercopithecid species present in the park were sampled: Cercopithecus diana, Cercopithecus campbelli, Cercopithecus petaurista, Procolobus badius, Procolobus verus, Colobus polykomos, and Cercocebus atys. We collected 3142 monkey stool samples between November 2009 and December 2010. Stool samples were processed by direct wet mount examination, formalin-ethyl acetate concentration, and MIF (merthiolate, iodine, formalin) concentration methods. Slides were examined under microscope and parasite identification was based on the morphology of cysts, eggs, and adult worms. A total of 23 species of parasites was recovered including 9 protozoa (Entamoeba coli, Entamoeba histolytica/dispar, Entamoeba hartmanni, Endolimax nana, Iodamoeba butschlii, Chilomastix mesnili, Giardia sp., Balantidium coli, and Blastocystis sp.), 13 nematodes (Oesophagostomum sp., Ancylostoma sp., Anatrichosoma sp., Capillariidae Gen. sp. 1, Capillariidae Gen. sp. 2, Chitwoodspirura sp., Subulura sp., spirurids [cf Protospirura muricola], Ternidens sp., Strongyloides sp., Trichostrongylus sp., and Trichuris sp.), and 1 trematode (Dicrocoelium sp.). Diversity indices and parasite richness were high for all monkey taxa, but C. diana, C. petaurista, C. atys, and C. campbelli exhibited a greater diversity of parasite species and a more equitable distribution. The parasitological data reported are the first available for these cercopithecid species within Taï National Park. PMID:25619957

  19. Three-dimensional structure of ectatomin from Ectatomma tuberculatum ant venom.

    PubMed

    Nolde, D E; Sobol, A G; Pluzhnikov, K A; Grishin, E V; Arseniev, A S

    1995-01-01

    Two-dimensional 1H NMR techniques were used to determine the spatial structure of ectatomin, a toxin from the venom of the ant Ectatomma tuberculatum. Nearly complete proton resonance assignments for two chains of ectatomin (37 and 34 amino acid residues, respectively) were obtained using 2D TOCSY, DQF-COSY and NOESY experiments. The cross-peak volumes in NOESY spectra were used to define the local structure of the protein and generate accurate proton-proton distance constraints employing the MARDIGRAS program. Disulfide bonds were located by analyzing the global fold of ectatomin, calculated with the distance geometry program DIANA. These data, combined with data on the rate of exchange of amide protons with deuterium, were used to obtain a final set of 20 structures by DIANA. These structures were refined by unrestrained energy minimization using the CHARMm program. The resulting rms deviations over 20 structures (excluding the mobile N- and c-termini of each chain) are 0.75 A for backbone heavy atoms, and 1.25 A for all heavy atoms. The conformations of the two chains are similar. Each chain consists of two alpha-helices and a hinge region of four residues; this forms a hairpin structure which is stabilized by disulfide bridges. The hinge regions of the two chains are connected together by a third disulfide bridge. Thus, ectatomin forms a four-alpha-helical bundle structure.

  20. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.

    PubMed

    Szyperski, T; Fernández, C; Mumenthaler, C; Wüthrich, K

    1998-03-01

    The human glioma pathogenesis-related protein (GliPR) is highly expressed in the brain tumor glioblastoma multiforme and exhibits 35% amino acid sequence identity with the tomato pathogenesis-related (PR) protein P14a, which has an important role for the plant defense system. A molecular model of GliPR was computed with the distance geometry program DIANA on the basis of a P14a-GliPR sequence alignment and a set of 1,200 experimental NMR conformational constraints collected with P14a. The GliPR structure is represented by a group of 20 conformers with small residual DIANA target function values, low AMBER-energies after restrained energy-minimization with the program OPAL, and an average rms deviation relative to the mean of 1.6 A for the backbone heavy atoms. Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. This cluster is conserved in all known plant PR proteins of class 1, indicating a common putative active site for GliPR and PR-1 proteins and thus a functional link between the human immune system and a plant defense system. PMID:9482873

  1. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system

    PubMed Central

    Szyperski, T.; Fernández, C.; Mumenthaler, C.; Wüthrich, K.

    1998-01-01

    The human glioma pathogenesis-related protein (GliPR) is highly expressed in the brain tumor glioblastoma multiforme and exhibits 35% amino acid sequence identity with the tomato pathogenesis-related (PR) protein P14a, which has an important role for the plant defense system. A molecular model of GliPR was computed with the distance geometry program diana on the basis of a P14a–GliPR sequence alignment and a set of 1,200 experimental NMR conformational constraints collected with P14a. The GliPR structure is represented by a group of 20 conformers with small residual diana target function values, low amber-energies after restrained energy-minimization with the program opal, and an average rms deviation relative to the mean of 1.6 Å for the backbone heavy atoms. Comparison of the GliPR model with the P14a structure lead to the identification of a common partially solvent-exposed spatial cluster of four amino acid residues, His-69, Glu-88, Glu-110, and His-127 in the GliPR numeration. This cluster is conserved in all known plant PR proteins of class 1, indicating a common putative active site for GliPR and PR-1 proteins and thus a functional link between the human immune system and a plant defense system. PMID:9482873

  2. Tensiometer-Based Irrigation Management of Subirrigated Soilless Tomato: Effects of Substrate Matric Potential Control on Crop Performance.

    PubMed

    Montesano, Francesco F; Serio, Francesco; Mininni, Carlo; Signore, Angelo; Parente, Angelo; Santamaria, Pietro

    2015-01-01

    Automatic irrigation scheduling based on real-time measurement of soilless substrate water status has been recognized as a promising approach for efficient greenhouse irrigation management. Identification of proper irrigation set points is crucial for optimal crop performance, both in terms of yield and quality, and optimal use of water resources. The objective of the present study was to determine the effects of irrigation management based on matric potential control on growth, plant-water relations, yield, fruit quality traits, and water-use efficiency of subirrigated (through bench system) soilless tomato. Tensiometers were used for automatic irrigation control. Two cultivars, "Kabiria" (cocktail type) and "Diana" (intermediate type), and substrate water potential set-points (-30 and -60 hPa, for "Diana," and -30, -60, and -90 hPa for "Kabiria"), were compared. Compared with -30 hPa, water stress (corresponding to a -60 hPa irrigation set-point) reduced water consumption (14%), leaf area (18%), specific leaf area (19%), total yield (10%), and mean fruit weight (13%), irrespective of the cultivars. At -60 hPa, leaf-water status of plants, irrespective of the cultivars, showed an osmotic adjustment corresponding to a 9% average osmotic potential decrease. Total yield, mean fruit weight, plant water, and osmotic potential decreased linearly when -30, -60, and -90 hPa irrigation set-points were used in "Kabiria." Unmarketable yield in "Diana" increased when water stress was imposed (187 vs. 349 g·plant(-1), respectively, at -30 and -60 hPa), whereas the opposite effect was observed in "Kabiria," where marketable yield loss decreased linearly [by 1.05 g·plant(-1) per unit of substrate water potential (in the tested range from -30 to -90 hPa)]. In the second cluster, total soluble solids of the fruit and dry matter increased irrespective of the cultivars. In the seventh cluster, in "Diana," only a slight increase was observed from -30 vs. -60 hPa (3.3 and 1

  3. Learning with technology: use of case-based physical and computer simulations in professional education.

    PubMed

    Lyons, J; Miller, M; Milton, J

    1998-06-01

    This paper describes a multimedia technology project in midwifery education and how it is being developed to improve student learning experiences and outcomes. The role of the university providing quality education relevant to today's world and professional practice is emphasised. A collaborative (Royal Melbourne Institute of Technology and Australian Catholic University) interdisciplinary project 'Pregnancy Simulator: Developing and Enhancing Student Learning of Pregnancy Assessment Skills' was developed with university and direct Commonwealth support. This project consists of a physical simulation of a pregnant woman at term and case-based multimedia computer simulations designed to develop and enhance student learning of abdominal assessment skills. A key feature of the development has been to design a learning experience explicitly on an authoritative theory-based view of teaching, in this case Diana Laurillard's 'Conversational Framework'.

  4. The Unappreciated Ramifications of the "Triple Obstetric Tragedy".

    PubMed

    Quigley, James

    2015-06-01

    The untimely death of a young Princess of Wales reverberated around the world in August 1997. Diana, Princess of Wales, was not, however, the first holder of that title to suffer an early demise. Princess Charlotte of Wales was fifteen years younger and died exactly one hundred and eighty years earlier. A national feeling of grief and desolation consumed the nation in the same way as it did following the death of the "People's Princess" in the twentieth century. Her death during childbirth led to a change in the practice of obstetrics and a succession crisis in the British monarchy. But were the consequences of the fateful night of 6th November 1817 to be even more profound, indirectly contributing to war in Europe a century later?

  5. Wing compliance in self-propelled flapping flyers

    NASA Astrophysics Data System (ADS)

    Ramananarivo, Sophie; Thiria, Benjamin; Godoy-Diana, Ramiro

    2010-11-01

    Wing flexibility governs the flying performance of flapping wing flyers. Here we use the self-propelled flapping-wing model mounted on a "merry-go-round" described by Thiria and Godoy-Diana (Phys. Rev. E 82, 015303, 2010) to investigate the effect of chord-wise wing compliance on the propulsive performance of the system. The bending of the wings, which is driven mainly by wing inertia in the present experiments, redistributes the aerodynamic forces engendered by the flapping motion and improves the efficiency of the system for a wide range of wing flexibilities and flapping frequencies. A detailed analysis of the phase dynamics between the leading and trailing edges of the wings allows us to pinpoint the mechanisms that limit the beneficial effect of wing compliance.

  6. New Display-type Analyzer for Three-dimensional Fermi Surface Mapping and Atomic Orbital Analysis

    SciTech Connect

    Takahashi, Nobuaki; Matsuda, Hiroyuki; Shigenai, Shin; Hirama, Yoshiteru; Matsui, Fumihiko; Hamada, Yoji; Nakanishi, Koji; Namba, Hidetoshi; Kitamura, Toshiro; Soejima, Hiroyoshi; Daimon, Hiroshi

    2007-01-19

    We have developed and installed a new Display-type ANAlyzer (DIANA) at Ritsumeikan SR center BL-7. We measured the angle-integrated energy distribution curve of poly-crystal gold and the photoelectron intensity angular distribution (PIAD) of HOPG to estimate the total energy resolution and to check the condition of the analyzer. The total energy resolution ({delta}E/E) is up to 0.78%, which is much higher than the old type. The PIAD of HOPG we obtained was the ring pattern as expected. Therefore, a detailed three-dimensional Fermi surface mapping and an analysis of the atomic orbitals constituting the electron energy bands are possible by combining them with a linearly polarized synchrotron radiation.

  7. Verification of the MAS TMM by infrared TB/TV testing methods

    NASA Astrophysics Data System (ADS)

    Szigetvari, Z.

    1990-09-01

    The structural/Thermal Mathematical Model (TMM) of the remote sensing instrument MAS (Microwave Atmospheric Sounder) was successfully TB/TV tested in a space simulation chamber. MAS is thermally characterized by strongly varying orbital heat loads and multiple solar reflections when situated in the orbiter cargo bay. Due to the complicated orbital environment and to budget limitations, the test objectives were simplified and achieved by infrared TB/TV testing methods. The simulation of the external radiative heat loads from Sun, Earth and orbiter cargo bay walls was realized by controlling the test chamber shroud temperatures at desired levels. The activities during preparation, completion and evaluation of the conducted infrared TB/TV tests are described and among others the implemented test data evaluation system DIANA is highlighted.

  8. Formation of a narrow baryon resonance with positive strangeness in K{sup +} collisions with Xe nuclei

    SciTech Connect

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tumanov, G. K.; Verebryusov, V. S.

    2010-07-15

    The data on the charge-exchange reaction K{sup +}Xe {sup {yields}}K{sup 0}pXe', obtained with the bubble chamber DIANA, are reanalyzed using increased statistics and updated selections. Our previous evidence for formation of a narrow pK{sup 0} resonance with mass near 1538 MeV is confirmed. The statistical significance of the signal reaches some 8{sigma} (6{sigma}) standard deviations when estimated as S/{radical}B (S/{radical}B + S. The mass and intrinsic width of the {Theta}{sup +} baryon are measured as m = 1538 {+-} 2 MeV and {Gamma} = 0.39 {+-} 0.10 MeV.

  9. Instrumental design and expected performance of coupled-moderator near-backscattering spectrometer at J-PARC

    NASA Astrophysics Data System (ADS)

    Takahashi, N.; Shibata, K.; Sato, T. J.; Tamura, I.; Kajimoto, R.; Harjo, S.; Oikawa, K.; Arai, M.; Mezei, F.

    2007-11-01

    A near-backscattering (n-BS) crystal-analyzer neutron inelastic spectrometer, DIANA, has been proposed for construction at Japan Proton Accelerator Research Complex. It has originally been designed to view a decoupled non-poisoned moderator in order to obtain high intensity and good energy resolution. Recently, we have reconsidered the instrumental parameters including the type of moderator, by performing Monte-Carlo simulations in order to obtain better performance. Among four virtual n-BS spectrometers on different beam sources moderators, a coupled-moderator-source spectrometer has shown the best performance, i.e. compared to the original DIADA design between ninefold and fivefold enhanced intensities have been obtained with 21%-better to 35%-worse energy resolutions.

  10. New Display-type Analyzer for Three-dimensional Fermi Surface Mapping and Atomic Orbital Analysis

    NASA Astrophysics Data System (ADS)

    Takahashi, Nobuaki; Matsui, Fumihiko; Matsuda, Hiroyuki; Shigenai, Shin; Hirama, Yoshiteru; Hamada, Yoji; Nakanishi, Koji; Namba, Hidetoshi; Kitamura, Toshiro; Soejima, Hiroyoshi; Daimon, Hiroshi

    2007-01-01

    We have developed and installed a new Display-type ANAlyzer (DIANA) at Ritsumeikan SR center BL-7. We measured the angle-integrated energy distribution curve of poly-crystal gold and the photoelectron intensity angular distribution (PIAD) of HOPG to estimate the total energy resolution and to check the condition of the analyzer. The total energy resolution (ΔE/E) is up to 0.78%, which is much higher than the old type. The PIAD of HOPG we obtained was the ring pattern as expected. Therefore, a detailed three-dimensional Fermi surface mapping and an analysis of the atomic orbitals constituting the electron energy bands are possible by combining them with a linearly polarized synchrotron radiation.

  11. Flexible Flapping Foils

    NASA Astrophysics Data System (ADS)

    Marais, Catherine; Godoy-Diana, Ramiro; Wesfreid, José. Eduardo

    2010-11-01

    Hydrodynamic tunnel experiments with flexible flapping foils of 4:1 span-to-chord aspect ratio are used in the present work to study the effect of foil compliance in the dynamical features of a propulsive wake. The average thrust force produced by the foil is estimated from 2D PIV measurements and the regime transitions in the wake are characterized according to a flapping frequency-amplitude phase diagram as in Godoy-Diana et al. (Phys. Rev. E 77, 016308, 2008). We show that the thrust production regime occurs on a broader region of the parameter space for flexible foils, with propulsive forces up to 3 times greater than for the rigid case. We examine in detail the vortex generation at the trailing edge of the foils, and propose a mechanism to explain how foil deformation leads to an optimization of propulsion.

  12. Vector and Axial-Vector Structures of the Θ+

    NASA Astrophysics Data System (ADS)

    Kim, Hyun-Chul; Ledwig, Tim; Goeke, Klaus

    We present in this talk recent results of the vector and axial-vector transitions of the nucleon to the pentaquark baryon Θ+, based on the SU(3) chiral quark-soliton model. The results are summarized as follows: K*NΘ vector and tensor coupling constants turn out to be gK*NΘ ≃ 0.81 and fK*NΘ ≃ 0.84, respectively, and the KNΘ axial-vector coupling constant to be g*A ˜= 0.05. As a result, the total decay width for Θ+ → NK becomes very small: ΓΘ→NK ≃ 0.71 MeV, which is consistent with the DIANA result ΓΘ→NK = 0.36 ± 0.11 MeV.

  13. Physician involvement enhances coding accuracy to ensure national standards: an initiative to improve awareness among new junior trainees.

    PubMed

    Nallasivan, S; Gillott, T; Kamath, S; Blow, L; Goddard, V

    2011-06-01

    Record Keeping Standards is a development led by the Royal College of Physicians of London (RCP) Health Informatics Unit and funded by the National Health Service (NHS) Connecting for Health. A supplementary report produced by the RCP makes a number of recommendations based on a study held at an acute hospital trust. We audited the medical notes and coding to assess the accuracy, documentation by the junior doctors and also to correlate our findings with the RCP audit. Northern Lincolnshire & Goole Hospitals NHS Foundation Trust has 114,000 'finished consultant episodes' per year. A total of 100 consecutive medical (50) and rheumatology (50) discharges from Diana Princess of Wales Hospital from August-October 2009 were reviewed. The results showed an improvement in coding accuracy (10% errors), comparable to the RCP audit but with 5% documentation errors. Physician involvement needs enhancing to improve the effectiveness and to ensure clinical safety. PMID:21677911

  14. X-chromosomal window into the evolutionary history of the guenons (Primates: Cercopithecini).

    PubMed

    Tosi, Anthony J; Detwiler, Kate M; Disotell, Todd R

    2005-07-01

    Molecular studies of the guenons suggest that the arboreal Cercopithecus species form a monophyletic group within the tribe Cercopithecini. However, the evolutionary relationships among these arboreal congeners remain poorly resolved. The present work marks the first attempt to reconstruct the history of this group through the phylogenetic analysis of long nuclear sequences. We surveyed 19 guenons and seven outgroup taxa for a approximately 9.3kb fragment of X-chromosomal DNA homologous to a portion of human Xq13.3. Parsimony and maximum likelihood analyses of these sequences consistently recover two strongly-supported patterns within the arboreal Cercopithecus clade: (1) a clustering of members of the cephus and mitis species groups, and (2) a monophyletic aggregate including the mona, neglectus, and diana species groups. Although guenons occasionally hybridize in the wild, interbreeding forms of different species groups do not cluster together as sister-taxa in the X-chromosomal tree, suggesting that the two clades inferred here are not reticulate patterns due to recent gene flow. These clades are most likely the result of either ancestral hybridization or true phylogenetic history. We advocate the latter explanation because the same two aggregates (cephus/mitis and mona/neglectus/diana) are recovered, albeit with weak support, by a number of earlier analyses. Finally, X-chromosomal divergence dates are estimated for a number of nodes in the guenon radiation. The divergence of guenon and papionin lineages at 11.5 (+/-1.3) MYA appears to be a particularly robust estimate since it is inferred from both mitochondrial and X-chromosomal studies, each using different fossil calibration points.

  15. Genetically engineered Mengo virus vaccination of multiple captive wildlife species.

    PubMed

    Backues, K A; Hill, M; Palmenberg, A C; Miller, C; Soike, K F; Aguilar, R

    1999-04-01

    Encephalomyocarditis virus (EMCV), has caused the deaths of many species of animals in zoological parks and research institutions. The Audubon Park Zoo, (New Orleans, Louisiana, USA) attempted vaccination of several species with a killed EMCV vaccine with mixed results. This paper reports an attempt at vaccination against EMCV using a genetically engineered, live attenuated Mengo virus (vMC0) at the Audubon Park Zoo and Miami Metro Zoo, (Miami, Florida, USA) from December 1996 to June 1997. Several species of animals were vaccinated with vMC0, which is serologically indistinguishable from the field strain of EMCV. Serum samples were taken at the time of vaccination and again 21 days later, then submitted for serum neutralization titers against EMCV. The vaccinate species included red capped mangebey (Cercocebus torquatus), colobus (Colobus guereza), angolan colobus (Colobus angolensis), ruffed lemur (Lemur variegatus ruber and Lemur variegatus variegatus), back lemur (Lemur macaco), ring-tailed lemur (Lemur catta), siamang (Hylobates syndactylus), diana guenon (Cercopithicus diana), spider monkey (Ateles geoffroyi), common marmoset (Callithrix jacchus), talapoin monkey (Cercopithecus talapoin), Brazilian tapir (Tapirus terrestris), Baird's tapir (Tapirus bairdii), Malayan tapir (Tapirus indicus), dromedary camel (Camelus dromedarius), bactrian camel (Camelus bactrianus), gerenuk (Litocranius walleri), guanaco (Lama glama guanicoe), black duiker (Cephalophus niger), Vietnamese potbellied pig (Sus scrofa), babirusa (Babyrousa babyrussa), collard peccary (Tayass tajacu), and African crested porcupine (Hystrix africaeaustralis). The vaccine response was variable, with high virus neutralizing antibody titer responses in some primate species and mixed to poor responses for other species. No ill effects were seen with vaccination. PMID:10231768

  16. Practical Aspects of microRNA Target Prediction.

    PubMed

    Witkos, T M; Koscianska, E; Krzyzosiak, W J

    2011-03-01

    microRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at the posttranscriptional level. These small regulatory molecules play a key role in the majority of biological processes and their expression is also tightly regulated. Both the deregulation of genes controlled by miRNAs and the altered miRNA expression have been linked to many disorders, including cancer, cardiovascular, metabolic and neurodegenerative diseases. Therefore, it is of particular interest to reliably predict potential miRNA targets which might be involved in these diseases. However, interactions between miRNAs and their targets are complex and very often there are numerous putative miRNA recognition sites in mRNAs. Many miRNA targets have been computationally predicted but only a limited number of these were experimentally validated. Although a variety of miRNA target prediction algorithms are available, results of their application are often inconsistent. Hence, finding a functional miRNA target is still a challenging task. In this review, currently available and frequently used computational tools for miRNA target prediction, i.e., PicTar, TargetScan, DIANA-microT, miRanda, rna22 and PITA are outlined and various practical aspects of miRNA target analysis are extensively discussed. Moreover, the performance of three algorithms (PicTar, TargetScan and DIANA-microT) is both demonstrated and evaluated by performing an in-depth analysis of miRNA interactions with mRNAs derived from genes triggering hereditary neurological disorders known as trinucleotide repeat expansion diseases (TREDs), such as Huntington's disease (HD), a number of spinocerebellar ataxias (SCAs), and myotonic dystrophy type 1 (DM1).

  17. Optimal lunar trajectories for a combined chemical-electric propulsion spacecraft

    NASA Astrophysics Data System (ADS)

    Kluever, Craig A.

    1995-01-01

    Spacecraft which utilize electric propulsion (EP) systems are capable of delivering a greater payload fraction compared to spacecraft using conventional chemical propulsion systems. Several researchers have investigated numerous applications of low-thrust EP including a manned Mars mission, scientific missions to the outer planets, and lunar missions. In contrast, the study of optimal combined high and low-thrust spacecraft trajectories has been limited. In response to the release of NASA's 1994 Announcement of Opportunity (AO) for Discovery class interplanetary exploration missions, a preliminary investigation of a lunar comet rendezvous mission using a solar electric propulsion (SEP) spacecraft was performed. The Discovery mission (eventually named Diana) was envisioned to be a two-phase scientific exploration mission: the first phase involved exploration of the moon and second phase involved rendezvous with a comet. The initial phase began with a chemical propulsion translunar injection and chemical insertion into a lunar orbit, followed by a low-thrust SEP transfer to a circular, polar, low-lunar orbit (LLO). After scientific data was collected at the moon, the SEP spacecraft performed a spiral lunar escape maneuver to begin the interplanetary leg of the mission. After escape from the Earth-moon system, the SEP spacecraft maneuvered in interplanetary space and performed a rendezvous with a short period comet. An initial study that demonstrated the feasibility of using EP for the lunar and comet orbit transfer was performed under the grant NAG3-1581. This final report is a continuation of the initial research efforts in support of the Discovery mission proposal that was submitted to NASA Headquarters in October 1994. Section 2 discusses the lunar orbit transfer phase of the Diana mission which involves both chemical and electric propulsion stages. Section 3 discusses the chemical lunar orbit insertion (LOI) burn optimization. Finally, section 4 presents the

  18. An integrated tool for loop calculations: AITALC

    NASA Astrophysics Data System (ADS)

    Lorca, Alejandro; Riemann, Tord

    2006-01-01

    AITALC, a new tool for automating loop calculations in high energy physics, is described. The package creates Fortran code for two-fermion scattering processes automatically, starting from the generation and analysis of the Feynman graphs. We describe the modules of the tool, the intercommunication between them and illustrate its use with three examples. Program summaryTitle of the program:AITALC version 1.2.1 (9 August 2005) Catalogue identifier:ADWO Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWO Program obtainable from:CPC Program Library, Queen's University of Belfast, N. Ireland Computer:PC i386 Operating system:GNU/ LINUX, tested on different distributions SuSE 8.2 to 9.3, Red Hat 7.2, Debian 3.0, Ubuntu 5.04. Also on SOLARIS Programming language used:GNU MAKE, DIANA, FORM, FORTRAN77 Additional programs/libraries used:DIANA 2.35 ( QGRAF 2.0), FORM 3.1, LOOPTOOLS 2.1 ( FF) Memory required to execute with typical data:Up to about 10 MB No. of processors used:1 No. of lines in distributed program, including test data, etc.:40 926 No. of bytes in distributed program, including test data, etc.:371 424 Distribution format:tar gzip file High-speed storage required:from 1.5 to 30 MB, depending on modules present and unfolding of examples Nature of the physical problem:Calculation of differential cross sections for ee annihilation in one-loop approximation. Method of solution:Generation and perturbative analysis of Feynman diagrams with later evaluation of matrix elements and form factors. Restriction of the complexity of the problem:The limit of application is, for the moment, the 2→2 particle reactions in the electro-weak standard model. Typical running time:Few minutes, being highly depending on the complexity of the process and the FORTRAN compiler.

  19. H2O in Protoplanetary Disks: the Snow Line and the Planets' Nest

    NASA Astrophysics Data System (ADS)

    Antonellini, Stefano; Kamp, Inga; Woitke, Peter; Thi, Wing-Fai

    2013-07-01

    Protoplanetary disks represent the stage between the pre-stellar collapse of the molecolar cloud and the formation of a planetary system surrounding a main sequence star. The goal of the DIANA FP7 project (P.I.: P.Woitke) is to investigate the disks in multiwavelengths, considering available data of photometry and spectroscopy, and give reason of the observed single and global properties of the protoplanetary disks. It will work on a sample of 85 selected targets in different evolutionary stage and surrounding different central stars. At NIR-MIR wavelengths, it is possible observe many lines of water. Water is one of the main cooling agents of the disk, due to its abundance and the presence of energy levels with excitation temperatures from few tens to few thousands of Kelvin. Water can also exist in condensate phase (frozen on dust) outside the so-called "snow line", which increases the surface density of solid material and therefore helps the formation of planets. Using a range of water lines, we can scan the disk surface, thus probing the disk from the lowest to the highest temperature regions and potentially indirectly detect the presence of the "snow line". Spectroscopic data from Spitzer and Herschel is used to investigate the spatial distribution and the synthesis of water, in the context of the thermophysical structure of the disk. This study is carried out with the codes ProDiMo and MCMax, producing different models of disks and investigating the physical conditions to which the water spectroscopy is sensitive. The work is done as part of the FP7 DIANA project.

  20. A microclimate study on hypogea environments of ancient roman building.

    PubMed

    Scatigno, C; Gaudenzi, S; Sammartino, M P; Visco, G

    2016-10-01

    Roman hypogea, vernacular settlements or crypts, are underground places characterised by specific and unique challenges (RH<90% and almost constant temperature throughout the whole year) related to their relative isolation from the outdoor environment. These sites often require adequate monitoring tools providing complete environmental information in order to carry out appropriate strategies for scheduling routine maintenance and designing suitable layouts for their preservation. In this work we present the results of a carefully planned thermo-hygrometric monitoring campaign conducted in a peculiar Roman building (130CE), the "Casa di Diana" Mithraeum, sited in Ostia Antica (archaeological site, Rome-Italy), with the aim of characterising the indoor environment as the structure suffers of several conservation problems (biocolonisation, efflorescences, evaporating and condensing cycle for wall-building materials). The campaign involving multipoint continuous measurement was carefully planned to better describe this micro-clime. In addition to underground environmental data available in literature, we have also performed, as a checkpoint control, a thermo-hygrometric monitoring campaign in the "Terme di Mitra" Hypogeum, a few meters from the "Casa di Diana". The recorded data was analysed by multivariate statistical and chemometric analyses. The results brought to light the presence of different microclimates (three areas) within a single Mithraeum: a room (pre-Mithraeum) and an area (Mithraeum: 2-4m) present a thermo-hygrometric environmental behaviour in accordance with a semi-confined environment, another area (Mithraeum: 1-2m) behaves accordingly with underground environments (although it cannot be described as such), and the last area (Mithraeum: 0-1m) where was recording RH values close to saturation (96-99%), associated with non-ventilated areas where the rising damp is "held" and not dispersed, describing an own micro-clime, comparable to a "small greenhouse

  1. Permanent Habitats in Earth-Sol/Mars-Sol Orbit Positions

    NASA Astrophysics Data System (ADS)

    Greenspon, J.

    Project Outpost is a manned Earth-Sol/Mars-Sol platform that enables permanent occupation in deep space. In order to develop the program elements for this complex mission, Project Outpost will rely primarily on existing/nearterm technology and hardware for the construction of its components. For the purposes of this study, four mission requirements are considered: 1. Outpost - Man's 1st purpose-produced effort of space engineering, in which astructure is developed/constructed in an environment completely alien to currentpractices for EVA guidelines. 2. Newton - a concept study developed at StarGate Research, for the development ofa modified Hohmann personnel orbital transport operating between Earth andMars. Newton would serve as the primary crew delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization. 3. Cruis - a concept study developed at StarGate Research, for the development of amodified Hohmann cargo orbital transport operating between Earth and Mars.Cruis would serve as the primary equipment delivery apparatus throughrepeatable transfer scheduling for all Earth-Lpoint-Mars activities. Thispermanent "transit system" would establish the foundations for Solar systemcolonization, and 4. Ares/Diana - a more conventional space platform configuration for Lunar andMars orbit is included as a construction baseline. The operations of these assetsare supported, and used for the support, of the outpost. Outpost would be constructed over a 27-year period of launch opportunities into Earth-Sol or Mars-Sol Lagrange orbit (E-S/M-S L1, 4 or 5). The outpost consists of an operations core with a self-contained power generation ability, a docking and maintenance structure, a Scientific Research complex and a Habitation Section. After achieving initial activation, the core will provide the support and energy required to operate the outpost in a 365

  2. Tensiometer-Based Irrigation Management of Subirrigated Soilless Tomato: Effects of Substrate Matric Potential Control on Crop Performance

    PubMed Central

    Montesano, Francesco F.; Serio, Francesco; Mininni, Carlo; Signore, Angelo; Parente, Angelo; Santamaria, Pietro

    2015-01-01

    Automatic irrigation scheduling based on real-time measurement of soilless substrate water status has been recognized as a promising approach for efficient greenhouse irrigation management. Identification of proper irrigation set points is crucial for optimal crop performance, both in terms of yield and quality, and optimal use of water resources. The objective of the present study was to determine the effects of irrigation management based on matric potential control on growth, plant–water relations, yield, fruit quality traits, and water-use efficiency of subirrigated (through bench system) soilless tomato. Tensiometers were used for automatic irrigation control. Two cultivars, “Kabiria” (cocktail type) and “Diana” (intermediate type), and substrate water potential set-points (−30 and −60 hPa, for “Diana,” and −30, −60, and −90 hPa for “Kabiria”), were compared. Compared with −30 hPa, water stress (corresponding to a −60 hPa irrigation set-point) reduced water consumption (14%), leaf area (18%), specific leaf area (19%), total yield (10%), and mean fruit weight (13%), irrespective of the cultivars. At −60 hPa, leaf-water status of plants, irrespective of the cultivars, showed an osmotic adjustment corresponding to a 9% average osmotic potential decrease. Total yield, mean fruit weight, plant water, and osmotic potential decreased linearly when −30, −60, and −90 hPa irrigation set-points were used in “Kabiria.” Unmarketable yield in “Diana” increased when water stress was imposed (187 vs. 349 g·plant−1, respectively, at −30 and −60 hPa), whereas the opposite effect was observed in “Kabiria,” where marketable yield loss decreased linearly [by 1.05 g·plant−1 per unit of substrate water potential (in the tested range from −30 to −90 hPa)]. In the second cluster, total soluble solids of the fruit and dry matter increased irrespective of the cultivars. In the seventh cluster, in “Diana,” only a

  3. Meaning and emotion in animal vocalizations.

    PubMed

    Seyfarth, Robert M; Cheney, Dorothy L

    2003-12-01

    Historically, a dichotomy has been drawn between the semantic communication of human language and the apparently emotional calls of animals. Current research paints a more complicated picture. Just as scientists have identified elements of human speech that reflect a speaker's emotions, field experiments have shown that the calls of many animals provide listeners with information about objects and events in the environment. Like human speech, therefore, animal vocalizations simultaneously provide others with information that is both semantic and emotional. In support of this conclusion, we review the results of field experiments on the natural vocalizations of African vervet monkeys, diana monkeys, baboons, and suricates (a South African mongoose). Vervet and diana monkeys give acoustically distinct alarm calls in response to the presence of leopards, eagles, and snakes. Each alarm call type elicits a different, adaptive response from others nearby. Field experiments demonstrate that listeners compare these vocalizations not just according to their acoustic properties but also according to the information they convey. Like monkeys, suricates give acoustically distinct alarm calls in response to different predators. Within each predator class, the calls also differ acoustically according to the signaler's perception of urgency. Like speech, therefore, suricate alarm calls convey both semantic and emotional information. The vocalizations of baboons, like those of many birds and mammals, are individually distinctive. As a result, when one baboon hears a sequence of calls exchanged between two or more individuals, the listener acquires information about social events in its group. Baboons, moreover, are skilled "eavesdroppers:" their response to different call sequences provides evidence of the sophisticated information they acquire from other individuals' vocalizations. Baboon males give loud "wahoo" calls during competitive displays. Like other vocalizations, these

  4. Acoustic sensor planning for gunshot location in national parks: a pareto front approach.

    PubMed

    González-Castaño, Francisco Javier; Alonso, Javier Vales; Costa-Montenegro, Enrique; López-Matencio, Pablo; Vicente-Carrasco, Francisco; Parrado-García, Francisco J; Gil-Castiñeira, Felipe; Costas-Rodríguez, Sergio

    2009-01-01

    In this paper, we propose a solution for gunshot location in national parks. In Spain there are agencies such as SEPRONA that fight against poaching with considerable success. The DiANa project, which is endorsed by Cabaneros National Park and the SEPRONA service, proposes a system to automatically detect and locate gunshots. This work presents its technical aspects related to network design and planning. The system consists of a network of acoustic sensors that locate gunshots by hyperbolic multi-lateration estimation. The differences in sound time arrivals allow the computation of a low error estimator of gunshot location. The accuracy of this method depends on tight sensor clock synchronization, which an ad-hoc time synchronization protocol provides. On the other hand, since the areas under surveillance are wide, and electric power is scarce, it is necessary to maximize detection coverage and minimize system cost at the same time. Therefore, sensor network planning has two targets, i.e., coverage and cost. We model planning as an unconstrained problem with two objective functions. We determine a set of candidate solutions of interest by combining a derivative-free descent method we have recently proposed with a Pareto front approach. The results are clearly superior to random seeding in a realistic simulation scenario.

  5. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults' Evaluations of Authentic Objects.

    PubMed

    Frazier, Brandy N; Gelman, Susan A; Wilson, Alice; Hood, Bruce

    2009-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults' evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person's attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults.

  6. The Sacred Mountain of Varallo in Italy: seismic risk assessment by acoustic emission and structural numerical models.

    PubMed

    Carpinteri, Alberto; Lacidogna, Giuseppe; Invernizzi, Stefano; Accornero, Federico

    2013-01-01

    We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named "The Sacred Mountain of Varallo." Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the "Sacred Mountain of Varallo" and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects. PMID:24381511

  7. Tools for the advancement of undergraduate statistics education

    NASA Astrophysics Data System (ADS)

    Schaffner, Andrew Alan

    To keep pace with advances in applied statistics and to maintain literate consumers of quantitative analyses, statistics educators stress the need for change in the classroom (Cobb, 1992; Garfield, 1993, 1995; Moore, 1991a; Snee, 1993; Steinhorst and Keeler, 1995). These authors stress a more concept oriented undergraduate introductory statistics course which emphasizes true understanding over mechanical skills. Drawing on recent educational research, this dissertation attempts to realize this vision by developing tools and pedagogy to assist statistics instructors. This dissertation describes statistical facets, pieces of statistical understanding that are building blocks of knowledge, and discusses DIANA, a World-Wide Web tool for diagnosing facets. Further, I show how facets may be incorporated into course design through the development of benchmark lessons based on the principles of collaborative learning (diSessa and Minstrell, 1995; Cohen, 1994; Reynolds et al., 1995; Bruer, 1993; von Glasersfeld, 1991) and activity based courses (Jones, 1991; Yackel, Cobb and Wood, 1991). To support benchmark lessons and collaborative learning in large classes I describe Virtual Benchmark Instruction, benchmark lessons which take place on a structured hypertext bulletin board using the technology of the World-Wide Web. Finally, I present randomized experiments which suggest that these educational developments are effective in a university introductory statistics course.

  8. Fate of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches under different storage conditions.

    PubMed

    Alegre, Isabel; Abadias, Maribel; Anguera, Marina; Usall, Josep; Viñas, Inmaculada

    2010-10-01

    Consumption of fresh-cut produce has sharply increased recently causing an increase of foodborne illnesses associated with these products. As generally, acidic fruits are considered 'safe' from a microbiological point of view, the aim of this work was to study the growth and survival of Escherichia coli O157:H7, Salmonella and Listeria innocua on minimally-processed peaches. The three foodborne pathogens population increased more than 2 log(10)units on fresh-cut peach when stored at 20 and 25 degrees C after 48 h. At 10 degrees C only L. innocua grew more than 1 log(10)unit and it was the only pathogen able to grow at 5 degrees C. Differences in growth occurred between different peach varieties tested, with higher population increases in those varieties with higher pH ('Royal Glory' 4.73+/-0.25 and 'Diana' 4.12+/-0.18). The use of common strategies on extending shelf life of fresh-cut produce, as modified atmosphere packaging and the use of the antioxidant substance, ascorbic acid (2%w/v), did not affect pathogens' growth at any of the temperatures tested (5 and 25 degrees C). Minimally-processed peaches have shown to be a good substrate for foodborne pathogens' growth regardless use of modified atmosphere and ascorbic acid. Therefore, maintaining cold chain and avoiding contamination is highly necessary. PMID:20688227

  9. Observations of lightning in convective supercells within tropical storms and hurricanes

    NASA Technical Reports Server (NTRS)

    Lyons, Walter A.; Keen, Cecil S.

    1994-01-01

    Cloud-to-ground (CG) lightning observations from land-based lightning detection networks now allow monitoring this component of the electrical structure of tropical storms and hurricanes within a few hundred kilometers of the United States coastline. Several case studies confirm the long-held opinion that lightning is rather common within the outer rainbands. The general absence of CG lightning within the interior of mature tropical cyclones is also apparent. On the other hand, bursts of CG lightning near the circulation center of developing storms appear to precede periods of further deepening. The CG events are associated with convective supercells, whose anvil canopies can often obscure much of the underlying storm. Near-eyewall CG bursts preceding periods of intensification were noted in Hurricanes Diana (1984) and Florence (1988). A detailed case study of the 1987 unnamed tropical storm that struck the Texas-Louisiana coastline reveals that lightning was associated with two large supercells. These supercells appeared to be the trigger for the development of a closed circulation that formed several hours after the apparent low pressure center made landfall. Further studies of lightning may provide additional insight into the role of convective supercells in tropical storm intensification. It may also provide a useful diagnostic of impending deepening.

  10. Observations of lightning in convective supercells within tropical storms and hurricanes

    SciTech Connect

    Lyons, W.A.; Keen, C.S. |

    1994-08-01

    Cloud-to-ground (CG) lightning observations from land-based lightning detection networks now allow monitoring this component of the electrical structure of tropical storms and hurricanes within a few hundred kilometers of the United States coastline. Several case studies confirm the long-held opinion that lightning is rather common within the outer rainbands. The general absence of CG lightning within the interior of mature tropical cyclones is also apparent. On the other hand, bursts of CG lightning near the circulation center of developing storms appear to precede periods of further deepening. The CG events are associated with convective supercells, whose anvil canopies can often obscure much of the underlying storm. Near-eyewall CG bursts preceding periods of intensification were noted in Hurricanes Diana (1984) and Florence (1988). A detailed case study of the 1987 unnamed tropical storm that struck the Texas-Louisiana coastline reveals that lightning was associated with two large supercells. These supercells appeared to be the trigger for the development of a closed circulation that formed several hours after the apparent low pressure center made landfall. Further studies of lightning may provide additional insight into the role of convective supercells in tropical storm intensification. It may also provide a useful diagnostic of impending deepening.

  11. Adherence to WCRF/AICR cancer prevention recommendations and metabolic syndrome in breast cancer patients.

    PubMed

    Bruno, Eleonora; Gargano, Giuliana; Villarini, Anna; Traina, Adele; Johansson, Harriet; Mano, Maria Piera; Santucci De Magistris, Maria; Simeoni, Milena; Consolaro, Elena; Mercandino, Angelica; Barbero, Maggiorino; Galasso, Rocco; Bassi, Maria Chiara; Zarcone, Maurizio; Zagallo, Emanuela; Venturelli, Elisabetta; Bellegotti, Manuela; Berrino, Franco; Pasanisi, Patrizia

    2016-01-01

    Metabolic syndrome (MetS), conventionally defined by the presence of at least three out of five dismetabolic traits (abdominal obesity, hypertension, low plasma HDL-cholesterol and high plasma glucose and triglycerides), has been associated with both breast cancer (BC) incidence and prognosis. We investigated the association between the prevalence of MetS and a score of adherence to the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) recommendations for the prevention of cancer in a cross-sectional study of BC patients. The DIet and ANdrogen-5 study (DIANA-5) for the prevention of BC recurrences recruited 2092 early stage BC survivors aged 35-70. At recruitment, all women completed a 24-hour food frequency and physical activity diary on their consumption and activity of the previous day. Using these diaries we created a score of adherence to five relevant WCRF/AICR recommendations. The prevalence ratios (PRs) and 95% confidence intervals (CIs) of MetS associated with the number of recommendations met were estimated using a binomial regression model. The adjusted PRs of MetS decreased with increasing number of recommendations met (p < 0.001). Meeting all the five recommendations versus meeting none or only one was significantly associated with a 57% lower MetS prevalence (95% CI 0.35-0.73). Our results suggest that adherence to WCRF/AICR recommendations is a major determinant of MetS and may have a clinical impact.

  12. The social consequences of conspiracism: Exposure to conspiracy theories decreases intentions to engage in politics and to reduce one's carbon footprint.

    PubMed

    Jolley, Daniel; Douglas, Karen M

    2014-02-01

    The current studies explored the social consequences of exposure to conspiracy theories. In Study 1, participants were exposed to a range of conspiracy theories concerning government involvement in significant events such as the death of Diana, Princess of Wales. Results revealed that exposure to information supporting conspiracy theories reduced participants' intentions to engage in politics, relative to participants who were given information refuting conspiracy theories. This effect was mediated by feelings of political powerlessness. In Study 2, participants were exposed to conspiracy theories concerning the issue of climate change. Results revealed that exposure to information supporting the conspiracy theories reduced participants' intentions to reduce their carbon footprint, relative to participants who were given refuting information, or those in a control condition. This effect was mediated by powerlessness with respect to climate change, uncertainty, and disillusionment. Exposure to climate change conspiracy theories also influenced political intentions, an effect mediated by political powerlessness. The current findings suggest that conspiracy theories may have potentially significant social consequences, and highlight the need for further research on the social psychology of conspiracism. PMID:24387095

  13. The microRNA feedback regulation of p63 in cancer progression

    PubMed Central

    Lin, Changwei; Li, Xiaorong; Zhang, Yi; Guo, Yihang; Zhou, Jianyu; Gao, Kai; Dai, Jing; Hu, Gui; Lv, Lv; Du, Juan; Zhang, Yi

    2015-01-01

    The transcription factor p63 is a member of the p53 gene family that plays a complex role in cancer due to its involvement in epithelial differentiation, cell cycle arrest and apoptosis. MicroRNAs are a class of small, non-coding RNAs with an important regulatory role in various cellular processes, as well as in the development and progression of cancer. A number of microRNAs have been shown to function as transcriptional targets of p63. Conversely, microRNAs also can modulate the expression and activity of p63. However, the p63–microRNA regulatory circuit has not been addressed in depth so far. Here, computational genomic analysis was performed using miRtarBase, Targetscan, microRNA.ORG, DIANA-MICROT, RNA22-HSA and miRDB to analyze miRNA binding to the 3′UTR of p63. JASPAR (profile score threshold 80%) and TFSEARCH datasets were used to search transcriptional start sites for p53/p63 response elements. Remarkably, these data revealed 63 microRNAs that targeted p63. Furthermore, there were 39 microRNAs targeting p63 that were predicted to be regulated by p63. These analyses suggest a crosstalk between p63 and microRNAs. Here, we discuss the crosstalk between p63 and the microRNA network, and the role of their interactions in cancer. PMID:25726529

  14. Scapular Morphology and Forelimb Use during Foraging in Four Sympatric Cercopithecids.

    PubMed

    Dunham, Noah T; Kane, Erin E; McGraw, W Scott

    2015-01-01

    Most investigations of primate scapular morphology use differences in locomotion to explain variation; less is known about how scapular geometry covaries with nonlocomotor behavior. We examined forelimb use during foraging in 4 cercopithecids ranging throughout the Ivory Coast's Tai Forest. During 5-min feeding bouts, we recorded the frequency individuals of Piliocolobus badius, Colobus polykomos, Cercocebus atys and Cercopithecus diana performed 5 forelimb behaviors involved in the acquisition and introduction of food to the oral cavity. Scapulae from these populations were examined to determine whether differences in forelimb use were reflected in features known to correspond with varying degrees of arm flexion, abduction and elevation. Our results reveal that the species differ markedly in forelimb use and that these differences are interpretable via their scapular morphology. For example, P. badius engages in more frequent flexion, abduction and elevation of the arm above the head relative to C. polykomos, and red colobus scapulae are longer craniocaudally and have larger, more cranially directed supraspinous fossae than those of closely related black-and-white colobus. Our attempt to explore how nonlocomotor behavior covaries with skeletal morphology should provide for more informed interpretations of the primate fossil record. PMID:26745141

  15. Pharmaceuticals, alkylphenols and pesticides in Mediterranean coastal waters: Results from a pilot survey using passive samplers

    NASA Astrophysics Data System (ADS)

    Munaron, Dominique; Tapie, Nathalie; Budzinski, Hélène; Andral, Bruno; Gonzalez, Jean-Louis

    2012-12-01

    21 pharmaceuticals, 6 alkylphenols and 27 hydrophilic pesticides and biocides were investigated using polar organic contaminant integrative samplers (POCIS) during a large-scale study of contamination of French Mediterranean coastal waters. Marine and transitional water-bodies, defined under the EU Water Framework Directive were monitored. Our results show that the French Mediterranean coastal waters were contaminated with a large range of emerging contaminants, detected at low concentrations during the summer season. Caffeine, carbamazepine, theophilline and terbutaline were detected with a detection frequency higher than 83% in the coastal waters sampled, 4-nonylphenol (4-NP), 4-tert-octylphenol (4-OP) and 4-nonylphenol diethoxylate (NP2EO) were detected in all coastal waters sampled, and diuron, terbuthylazine, atrazine, irgarol and simazine were detected in more than 77% of samples. For pharmaceuticals, highest time-weighted average (TWA) concentrations were measured for caffeine and carbamazepine (32 and 12 ng L-1, respectively). For alkylphenols, highest TWA concentrations were measured for 4-nonylphenol mono-ethoxylate and 4-nonylphenol (41 and 33 ng L-1, respectively), and for herbicides and biocides, they were measured for diuron and irgarol (33 and 2.5 ng L-1, respectively). Except for Diana lagoon, lagoons and semi-enclosed bays were the most contaminated areas for herbicides and pharmaceuticals, whilst, for alkylphenols, levels of contamination were similar in lagoons and coastal waters. This study demonstrates the relevance and utility of POCIS as quantitative tool for measuring low concentrations of emerging contaminants in marine waters.

  16. Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology

    PubMed Central

    Busch, Albert; Busch, Martin; Scholz, Claus-Jürgen; Kellersmann, Richard; Otto, Christoph; Chernogubova, Ekaterina; Maegdefessel, Lars; Zernecke, Alma; Lorenz, Udo

    2016-01-01

    Limited comprehension of aneurysm pathology has led to inconclusive results from clinical trials. miRNAs are key regulators of post-translational gene modification and are useful tools in elucidating key features of aneurysm pathogenesis in distinct entities of abdominal and popliteal aneurysms. Here, surgically harvested specimens from 19 abdominal aortic aneurysm (AAA) and 8 popliteal artery aneurysm (PAA) patients were analyzed for miRNA expression and histologically classified regarding extracellular matrix (ECM) remodeling and inflammation. DIANA-based computational target prediction and pathway enrichment analysis verified our results, as well as previous ones. miRNA-362, -19b-1, -194, -769, -21 and -550 were significantly down-regulated in AAA samples depending on degree of inflammation. Similar or inverse regulation was found for miR-769, 19b-1 and miR-550, -21, whereas miR-194 and -362 were unaltered in PAA. In situ hybridization verified higher expression of miR-550 and -21 in PAA compared to AAA and computational analysis for target genes and pathway enrichment affirmed signal transduction, cell-cell-interaction and cell degradation pathways, in line with previous results. Despite the vague role of miRNAs for potential diagnostic and treatment purposes, the number of candidates from tissue signature studies is increasing. Tissue morphology influences subsequent research, yet comparison of distinct entities of aneurysm disease can unravel core pathways. PMID:26771601

  17. The NMR solution structure of the pheromone Er-11 from the ciliated protozoan Euplotes raikovi.

    PubMed Central

    Luginbühl, P.; Wu, J.; Zerbe, O.; Ortenzi, C.; Luporini, P.; Wüthrich, K.

    1996-01-01

    The NMR solution structure of the pheromone Er-11, a 39-residue protein from the ciliated protozoan Euplotes raikovi, was calculated with the distance geometry program DIANA from 449 NOE upper distance constraints and 97 dihedral angle constraints, and the program OPAL was employed for structure refinement by molecular mechanics energy minimization in a water bath. For a group of 20 conformers used to characterize the solution structure, the average of the pairwise RMS deviations from the mean structure calculated for the backbone heavy atoms N, C alpha, and C' of residues 2-38 was 0.30 A. The molecular architecture is dominated by an up-down-up bundle of three short helices with residues 2-9, 12-19, and 22-32, which is closely similar to the previously determined structures of the homologous pheromones Er-1, Er-2, and Er-10. This finding provides structural evidence for the capability shown by these pheromones to compete with each other in binding reactions to their cell-surface receptors. PMID:8844842

  18. To Boldly Go: America's Next Era in Space. Sustaining Life on the Earth

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. France Cordova, NASA's Chief Scientist, opened this, the sixth seminar in the Administrator's Seminar Series, by introducing NASA Administrator Daniel S. Goldin. Mr Goldin welcomed the attendees and set the stage for Dr. Cordova's introduction of the first speaker, Dr. Robert Kates of Brown University. Dr. Kates primary concerns are global environmental changes, world hunger, and the size of the population. Human changes, he said, rival the changes of nature. Changes in the size of world population affect the need for more agricultural products, therefore more land for growing food, which leads to deforestation, which affects rainfall, and therefore the water supply which is in increased demand. Human ingenuity can reduce some shortages but generally doesn't keep up with increased demand for life-sustaining essentials. These problems require the concern of intergovernmental organizations, treaties and activities, as well as transnational corporations, and non-governmental and private, volunteer organizations. Next Dr. Diana Liverman of Pennsylvania State University spoke on human interactions regarding climate and society. She considered the effect of changes in land use on climate, using Mexico as an example. Mexicans changed from raising much wheat to raising more fruits and vegetables. This was in response to the demands of the market. The results were more industry, population growth, greater income, drought (because the new crops required more water), and conflicts over water supplies. Dr. Charles Kennel of the Office of Mission to Planet Earth joined Dr.s Cordova, Kates, and Liverman for the question and answer session that followed.

  19. Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices

    NASA Astrophysics Data System (ADS)

    Gamzina, Diana

    Diana Gamzina March 2016 Mechanical and Aerospace Engineering Multiscale Thermo-Mechanical Design and Analysis of High Frequency and High Power Vacuum Electron Devices Abstract A methodology for performing thermo-mechanical design and analysis of high frequency and high average power vacuum electron devices is presented. This methodology results in a "first-pass" engineering design directly ready for manufacturing. The methodology includes establishment of thermal and mechanical boundary conditions, evaluation of convective film heat transfer coefficients, identification of material options, evaluation of temperature and stress field distributions, assessment of microscale effects on the stress state of the material, and fatigue analysis. The feature size of vacuum electron devices operating in the high frequency regime of 100 GHz to 1 THz is comparable to the microstructure of the materials employed for their fabrication. As a result, the thermo-mechanical performance of a device is affected by the local material microstructure. Such multiscale effects on the stress state are considered in the range of scales from about 10 microns up to a few millimeters. The design and analysis methodology is demonstrated on three separate microwave devices: a 95 GHz 10 kW cw sheet beam klystron, a 263 GHz 50 W long pulse wide-bandwidth sheet beam travelling wave tube, and a 346 GHz 1 W cw backward wave oscillator.

  20. The social consequences of conspiracism: Exposure to conspiracy theories decreases intentions to engage in politics and to reduce one's carbon footprint.

    PubMed

    Jolley, Daniel; Douglas, Karen M

    2014-02-01

    The current studies explored the social consequences of exposure to conspiracy theories. In Study 1, participants were exposed to a range of conspiracy theories concerning government involvement in significant events such as the death of Diana, Princess of Wales. Results revealed that exposure to information supporting conspiracy theories reduced participants' intentions to engage in politics, relative to participants who were given information refuting conspiracy theories. This effect was mediated by feelings of political powerlessness. In Study 2, participants were exposed to conspiracy theories concerning the issue of climate change. Results revealed that exposure to information supporting the conspiracy theories reduced participants' intentions to reduce their carbon footprint, relative to participants who were given refuting information, or those in a control condition. This effect was mediated by powerlessness with respect to climate change, uncertainty, and disillusionment. Exposure to climate change conspiracy theories also influenced political intentions, an effect mediated by political powerlessness. The current findings suggest that conspiracy theories may have potentially significant social consequences, and highlight the need for further research on the social psychology of conspiracism.

  1. COMMITTEES COMMITTEES

    NASA Astrophysics Data System (ADS)

    2010-11-01

    ORGANISING COMMITTEE Chairman: Alexander G Petrov Director, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia, Bulgaria Chairman Emeritus: Nikolay Kirov Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia, Bulgaria Local Organising Committee: Chairman: Alexander G Petrov Members: Diana Nesheva, Doriana Dimova-Malinovska, Eleonora Popova, Lyubomila Dedinska, Christo Popov, Vasil Lovchinov, Marina Primatarowa, Emilia Vlaikova, Irina Velkova, Hassan Chamati PROGRAMME COMMITTEE Chairman: A G Petrov Members: D Alexandrov (Thunder Bay), V Celebonovic (Belgrade), D Dimova-Malinovska (Sofia), B Dulmet (Besancon), A Grechnikov (Moscow), M Gunes (Mugla), C Main (Dundee), D Nesheva (Sofia), M C Petty (Durham), M Popescu (Bucharest), S Reynolds (Dundee), K Shimakawa (Gifu), J Singh (Darwin), N Starbov (Sofia), M Tomilin (St Petersburg), Ph Vanderbemden (Liege), A Vaseashta (Washington) LOCAL SCIENTIFIC COUNCIL Chairman: A G Petrov Members: Bulgarian Academy of Sciences N Sabotinov (President) I Nedkov (Scientific Secretary, Physics) Institute of Solid State Physics N Kirov, D Nesheva, V Lovchinov, St Andreev, M Primatarowa Institute of Electronics R Enikov (Director) Central Lab. of Solar Energy and New Energy Sources D Dimova-Malinovska Institute of Optical Materials and Technologies V Saynov, N Starbov Central Lab. of Applied Physics R Kakanakov (Director) Sofia University - Faculty of Physics A Andreeva, S Russev (Heads of Departments)

  2. Structure and evolution of southeast Thetis Regio

    NASA Astrophysics Data System (ADS)

    Ghail, Richard C.

    2002-08-01

    The highland terrain in southeast Thetis Regio consists of a series of thrust faults and conjugate graben that would usually be classified as tesserae. Unusually, this small area of tesserae is younger than the adjacent plains, a conclusion strengthened by modification of Jumaisat crater, a parabolic dark-halo crater >75 Myr old. Two structural belts are distinguished, the eastern ridged terrain and the central plateau, separated by conjugate graben. Unlike most terrestrial mountain belts, the thrusts in southeast Thetis are outward dipping, implying obduction of the eastern plains onto Thetis. This most likely results from the buoyancy of the Venusian lithosphere, which inhibits subduction. A simple two-stage orogenic model is inferred. Plains crust, driven by extension in Diana Chasma, initially overrides higher-standing tesserae crust in southeast Thetis. Through interaction with a plume, or perhaps through convective instability of the lower lithosphere, a plateau forms that resists further compression and that exhibits extensive volcanism. A new area of thrusting in the ridged terrain develops, while the plateau starts to collapse along graben, the larger of which are filled with lavas. The core of Thetis Regio appears to be surrounded by other tectonic units like southeast Thetis, indicating a piecemeal construction similar to terrestrial continents.

  3. The NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi.

    PubMed Central

    Ottiger, M.; Szyperski, T.; Luginbühl, P.; Ortenzi, C.; Luporini, P.; Bradshaw, R. A.; Wüthrich, K.

    1994-01-01

    The NMR structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi has been determined in aqueous solution. The structure of this 40-residue protein was calculated with the distance geometry program DIANA from 621 distance constraints and 89 dihedral angle constraints; the program OPAL was employed for the energy minimization. For a group of 20 conformers used to characterize the solution structure, the average pairwise RMS deviation from the mean structure calculated for the backbone heavy atoms N, C alpha, and C' of residues 3-37 was 0.31 A. The molecular architecture is dominated by an up-down-up bundle of 3 short helices of residues 5-11, 14-20, and 23-33, which is similar to the structures of the homologous pheromones Er-1 and Er-10. Novel structural features include a well-defined N-cap on the first helix, a 1-residue deletion in the second helix resulting in the formation of a 3(10)-helix rather than an alpha-helix as found in Er-1 and Er-10, and the simultaneous presence of 2 different conformations for the C-terminal tetrapeptide segment, i.e., a major conformation with the Leu 39-Pro 40 peptide bond in the trans form and a minor conformation with this peptide bond in the cis form. PMID:7833811

  4. Ejection of heavy elements from the stellar core to the periphery of the cloud of ejecta during a supernova explosion: A possible model of the processes

    NASA Astrophysics Data System (ADS)

    Zmitrenko, N. V.; Rozanov, V. B.; Stepanov, R. V.; Yakhin, R. A.; Belyaev, V. S.

    2014-03-01

    The possibility of simulating the processes during supernova explosions in laboratory conditions using powerful lasers (laboratory astrophysics) is investigated. The Chandra observations of ejecta in the Cassiopeia A supernova remnant are analyzed. Based on the DIANA and NUTCY numerical codes, we have performed 1D and 2D hydrodynamic simulations of the ejecta expansion dynamics for a supernova with a mass of ˜5-15 solar masses within several hundred seconds after its explosion, including an initial asymmetry. We propose a model for the explosion and expansion of ejecta that illustrates strong inhomogeneities in the distribution of material to the extent that the Fe, Si, and S material from the stellar center turns out to be ejected to the periphery, the "star turns inside out," in agreement with observations. Based on hydrodynamic similarity criteria, we consider possible supernova-simulating laser targets that will allow one to reproduce the physical processes that take place during the explosion of an astrophysical object, such as the shock propagation through the material, the growth of hydrodynamic instabilities at the boundaries of envelopes with different densities, etc.

  5. Venus - 3D Perspective View of Latona Corona and Dali Chasma

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This computer-generated perspective view of Latona Corona and Dali Chasma on Venus shows Magellan radar data superimposed on topography. The view is from the northeast and vertical exaggeration is 10 times. Exaggeration of relief is a common tool scientists use to detect relationships between structure (i.e. faults and fractures) and topography. Latona Corona, a circular feature approximately 1,000 kilometers (620 miles) in diameter whose eastern half is shown at the left of the image, has a relatively smooth, radar-bright raised rim. Bright lines or fractures within the corona appear to radiate away from its center toward the rim. The rest of the bright fractures in the area are associated with the relatively deep (approximately 3 kilometers or 1.9 miles) troughs of Dali Chasma. The Dali and Diana Chasma system consist of deep troughs that extend for 7,400 kilometers (4,588 miles) and are very distinct features on Venus. Those chasma connect the Ovda and Thetis highlands with the large volcanoes at Atla Regio and thus are considered to be the 'Scorpion Tail' of Aphrodite Terra. The broad, curving scarp resembles some of Earth's subduction zones where crustal plates are pushed over each other. The radar-bright surface at the highest elevation along the scarp is similar to surfaces in other elevated regions where some metallic mineral such as pyrite (fool's gold) may occur on the surface.

  6. Galileo Science Update: Observing Changes on Europa and in Jupiter's System

    NASA Astrophysics Data System (ADS)

    1996-08-01

    This NASA Kennedy Space Center (KSC) video release presents a news briefing from the Jet Propulsion Laboratory (JPL) featuring video presentations by Dr. Alfred McEwen (Univ. of Arizona, Lunar and Planetary Lab.), Dr. Ronald Greeley (Arizona St. Univ.), Dr. Andrew Ingersoll (California Inst. of Tech.,), and Dr. Diana Blaney (Jet Propulsion Lab.). Discussions center on the atmospheric and surface features of Jupiter and two of its moons, Europa and Io. Possible energy mechanisms that create atmospheric features of Jupiter, such as the Great Red Spot, as well as possible thunderstorm and lightning activity associated with these features are included. Discussions of the craters and fractures on the icy surface of Europa, surface features of Io, two of which are named Loki and Pele, believed to be of volcanic origin, as well infrared observations of volcanism on Io are presented. The individual presentations are followed by a question and answer period with questions posed by scientific journalists from JPL and other NASA centers. The video ends with computer animations, as well as actual footage, of features on Jupiter and its satellites taken from the Galileo spacecraft. Some of these images were seen previously in the individual presentations.

  7. The Sacred Mountain of Varallo in Italy: Seismic Risk Assessment by Acoustic Emission and Structural Numerical Models

    PubMed Central

    Carpinteri, Alberto; Invernizzi, Stefano; Accornero, Federico

    2013-01-01

    We examine an application of Acoustic Emission (AE) technique for a probabilistic analysis in time and space of earthquakes, in order to preserve the valuable Italian Renaissance Architectural Complex named “The Sacred Mountain of Varallo.” Among the forty-five chapels of the Renaissance Complex, the structure of the Chapel XVII is of particular concern due to its uncertain structural condition and due to the level of stress caused by the regional seismicity. Therefore, lifetime assessment, taking into account the evolution of damage phenomena, is necessary to preserve the reliability and safety of this masterpiece of cultural heritage. A continuous AE monitoring was performed to assess the structural behavior of the Chapel. During the monitoring period, a correlation between peaks of AE activity in the masonry of the “Sacred Mountain of Varallo” and regional seismicity was found. Although the two phenomena take place on very different scales, the AE in materials and the earthquakes in Earth's crust, belong to the same class of invariance. In addition, an accurate finite element model, performed with DIANA finite element code, is presented to describe the dynamic behavior of Chapel XVII structure, confirming visual and instrumental inspections of regional seismic effects. PMID:24381511

  8. Molecular diversity of cotton leaf curl Gezira virus isolates and their satellite DNAs associated with okra leaf curl disease in Burkina Faso.

    PubMed

    Tiendrébéogo, Fidèle; Lefeuvre, Pierre; Hoareau, Murielle; Villemot, Julie; Konaté, Gnissa; Traoré, Alfred S; Barro, Nicolas; Traoré, Valentin S; Reynaud, Bernard; Traoré, Oumar; Lett, Jean-Michel

    2010-02-23

    Okra leaf curl disease (OLCD) is a major constraint on okra (Abelmoschus esculentus) production and is widespread in Africa. Using a large number of samples representative of the major growing regions in Burkina Faso (BF), we show that the disease is associated with a monopartite begomovirus and satellite DNA complexes. Twenty-three complete genomic sequences of Cotton leaf curl Gezira virus (CLCuGV) isolates associated with OLCD, sharing 95 to 99% nucleotide identity, were cloned and sequenced. Six betasatellite and four alphasatellite (DNA-1) molecules were also characterized. The six isolates of betasatellite associated with CLCuGV isolates correspond to Cotton leaf curl Gezira betasatellite (CLCuGB) (88 to 98% nucleotide identity). One isolate of alphasatellite is a variant of Cotton leaf curl Gezira alphasatellite (CLCuGA) (89% nucleotide identity), whereas the three others isolates appear to correspond to a new species of alphasatellite (CLCuGA most similar sequence present 52 to 60% nucleotide identity), provisionally named Okra leaf curl Burkina Faso alphasatellite (OLCBFA). Recombination analysis of the viruses demonstrated the interspecies recombinant origin of all CLCuGV isolates, with parents being close to Hollyhock leaf crumple virus (AY036009) and Tomato leaf curl Diana virus (AM701765). Combined with the presence of satellites DNA, these results highlight the complexity of begomoviruses associated with OLCD.

  9. Acoustic Sensor Planning for Gunshot Location in National Parks: A Pareto Front Approach

    PubMed Central

    González-Castaño, Francisco Javier; Alonso, Javier Vales; Costa-Montenegro, Enrique; López-Matencio, Pablo; Vicente-Carrasco, Francisco; Parrado-García, Francisco J.; Gil-Castiñeira, Felipe; Costas-Rodríguez, Sergio

    2009-01-01

    In this paper, we propose a solution for gunshot location in national parks. In Spain there are agencies such as SEPRONA that fight against poaching with considerable success. The DiANa project, which is endorsed by Cabaneros National Park and the SEPRONA service, proposes a system to automatically detect and locate gunshots. This work presents its technical aspects related to network design and planning. The system consists of a network of acoustic sensors that locate gunshots by hyperbolic multi-lateration estimation. The differences in sound time arrivals allow the computation of a low error estimator of gunshot location. The accuracy of this method depends on tight sensor clock synchronization, which an ad-hoc time synchronization protocol provides. On the other hand, since the areas under surveillance are wide, and electric power is scarce, it is necessary to maximize detection coverage and minimize system cost at the same time. Therefore, sensor network planning has two targets, i.e., coverage and cost. We model planning as an unconstrained problem with two objective functions. We determine a set of candidate solutions of interest by combining a derivative-free descent method we have recently proposed with a Pareto front approach. The results are clearly superior to random seeding in a realistic simulation scenario. PMID:22303135

  10. Using unsteady-state water level data to estimate channel roughness and discharge hydrograph

    NASA Astrophysics Data System (ADS)

    Aricò, Costanza; Nasello, Carmelo; Tucciarelli, Tullio

    2009-08-01

    A novel methodology for simultaneous discharge and channel roughness estimation is developed and applied to data sets available at three experimental sites. The methodology is based on the synchronous measurement of water level data in two river sections far some kilometers from each other, as well as on the use of a diffusive flow routing solver and does not require any direct velocity measurement. The methodology is first analyzed for the simplest case of a channel with a large slope, where the kinematic assumption holds. A sensitivity and a model error analysis are carried out in this hypothesis in order to show the stability of the results with respect to the error in the input parameters in the case of homogeneous roughness and to analyze the effect of unknown roughness heterogeneity on the estimated discharges. The methodology is then extended to the more general case of channels with mild slope and validated using field data previously collected in three Italian rivers: the Arno (in Tuscany), the Tiber (in Latium) and the Vallo di Diana, a small tributary of the Tanagro river (in Southern Italy). The performance of the proposed algorithm has been investigated according to three performance criteria estimating the quality of the match between the measured and the computed stage and discharge hydrographs. Results of the field tests can be considered good, despite the uncertainties of the field data and of the measured values.

  11. Measurement of the Total Cross Section for γn --> pπ- Near Threshold at MAX-lab

    NASA Astrophysics Data System (ADS)

    England, Khayla; MAX-TAGG Collaboration

    2011-10-01

    In nuclear science, researchers strive to describe the properties of the nucleons using the framework provided by QCD. A number of theoretical approaches to solving the QDC equations for nuclear processes exist. The predictions of these theories can be compared with the results from accurate experimental measurements for those nuclear reactions where both theory and experiment can provide accurate answers. One such reaction is pion photoproduction near threshold. A measurement of the total cross-section very close to threshold for the γ + n --> p +π- reaction is currently being performed using the Tagged Photon Facility at MAX-lab in Lund, Sweden. A LD2 target was used to provide the neutron target. Due to the target thickness, the π- were not detected directly but instead were captured on another nucleus in the target. This capture resulted in a nominal 128 MeV γ-ray approximately 25% of the time. This gamma-ray easily exited the target and was detected using three large NaI(Tl) detectors: CATS, BUNI, and DIANA. An overview of the measurement and preliminary results from the June 2011 run period will be presented. Sponsored by NSF OISE/IRES award 0553467.

  12. A Real-Time Imaging System for Stereo Atomic Microscopy at SPring-8's BL25SU

    NASA Astrophysics Data System (ADS)

    Matsushita, Tomohiro; Guo, Fang Zhun; Muro, Takayuki; Matsui, Fumihiko; Daimon, Hiroshi

    2007-01-01

    We have developed a real-time photoelectron angular distribution (PEAD) and Auger-electron angular distribution (AEAD) imaging system at SPring-8 BL25SU, Japan. In addition, a real-time imaging system for circular dichroism (CD) studies of PEAD/AEAD has been newly developed. Two PEAD images recorded with left- and right-circularly polarized light can be regarded as a stereo image of the atomic arrangement. A two-dimensional display type mirror analyzer (DIANA) has been installed at the beamline, making it possible to record PEAD/AEAD patterns with an acceptance angle of ±60° in real-time. The twin-helical undulators at BL25SU enable helicity switching of the circularly polarized light at 10Hz, 1Hz or 0.1Hz. In order to realize real-time measurements of the CD of the PEAD/AEAD, the CCD camera must be synchronized to the switching frequency. The VME computer that controls the ID is connected to the measurement computer with two BNC cables, and the helicity information is sent using TTL signals. For maximum flexibility, rather than using a hardware shutter synchronizing with the TTL signal we have developed software to synchronize the CCD shutter with the TTL signal. We have succeeded in synchronizing the CCD camera in both the 1Hz and 0.1Hz modes.

  13. Remote Semi-State Preparation as SuperDense Quantum Teleportation

    NASA Astrophysics Data System (ADS)

    Bernstein, Herbert J.

    2011-03-01

    Recent advances in experimental technique make SuperDense Teleportation (SDT) possible. The effect uses remote state preparation to send more state-specifying parameters per bit than ordinary quantum teleportation (QT) can transmit. SDT uses a maximal entanglement to teleport the relative phases of an {n}-dimensional equimodular state. This means that one can send only {n}-1 of the total (2 n - 2) parameters -- comprising the relative phases and amplitudes -- of a general state. Nevertheless, for {n} >= 3 , SDT sends more of these state-specifying parameters than QT for a given number of classical bits. In the limit of large {n} the ratio is 2 to 1, hence the nomenclature Bennett suggested, SDT, by analogy with Super Dense Coding. Alice's measurements and Bob's transformations are simpler than in QT. The roles of Charles the state chooser, and Diana who deploys it, are different than in QT. I briefly review possible experimental realizations, including two that are under consideration at the present time by an experimental group leading in higher-dimension entanglement work. Supported in part by NSF grants PHY97-22614 & 07-58149 & KITP, UCSB, including an ITP Scholar-ship.

  14. Experimental search for radiative decays of the pentaquark baryon Θ+(1540)

    NASA Astrophysics Data System (ADS)

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tumanov, G. K.; Verebryusov, V. S.

    2010-07-01

    The data on the reactions K +Xe → K 0 γX and K +Xe → K + γX, obtained with the bubble chamber DIANA, have been analyzed for possible radiative decays of the Θ+(1540) baryon: Θ+ → K 0 pγ and Θ+ → K + nγ. No signals have been observed, and we derive the upper limits Γ(Θ+ → K 0 pγ)/Γ(Θ+ → K 0 p) < 0.032 and Γ(Θ+ → K + nγ)/Γ(Θ+ → K + nγ) < 0.041 which, using our previous measurement of Γ(Θ+ → KN) = 0.39 ± 0.10 MeV, translate to Γ(Θ+ → K 0 pγ) < 8 keV and Γ(Θ+ → K + nγ) < 11 keV at 90% confidence level. We have also measured the cross sections of K +-induced reactions involving emission of a neutral pion: σ( K + n → K 0 pπ 0) = 68 ± 18 µb and σ( K + N → K + Nπ 0) = 30 ± 8 µb for incident K + momentum of 640 MeV.

  15. PREFACE: Processes in Isotopes and Molecules

    NASA Astrophysics Data System (ADS)

    Bogdan, Diana; Tosa, Valer

    2009-07-01

    These Proceedings present some of the Invited Lectures and Contributed Papers of the International Conference 'Processes in Isotopes and Molecules' (PIM), held in Cluj-Napoca, Romania, 24-26 September 2009. The PIM conference, started in 1999 as a local event, is now an international conference organized every two years by the National Institute for R&D of Isotopic and Molecular Technologies in Cluj-Napoca, the capital city of Transylvania, Romania. The meetings are attended by researchers in the field of atomic and molecular physics as well as those developing new materials and technologies. The scientific subjects are at the cross-roads of three fundamental research areas: physics, chemistry, and biology. The papers here are grouped according to the five conference topics: T1 - Molecular and biomolecular systems T2 - Modern techniques and technologies T3 - Environmental molecular processes T4 - Hydrogen and renewable sources of energy T5 - Nanostructured materials and nanocomposites We gratefully acknowledge the contribution of our colleagues from the Scientific Committee and Program Committee who contributed their time, energy and expertise to the refereeing process. Finally, we would like to thank people from IOP Publishing for their friendly advice and prompt help during the editing process, as well as for their efforts making the Journal of Physics: Conference Series available to the scientific community. Diana Bogdan and Valer Tosa National Institute for R&D Isotopic and Molecular Technologies, Cluj-Napoca

  16. Observation of a narrow baryon resonance with positive strangeness formed in K+Xe collisions

    NASA Astrophysics Data System (ADS)

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tarasov, V. V.; Tumanov, G. K.; Verebryusov, V. S.; Diana Collaboration

    2014-04-01

    The charge-exchange reaction K+Xe→K0pXe' is investigated using the data of the DIANA experiment. The distribution of the pK0 effective mass shows a prominent enhancement near 1538 MeV formed by nearly 80 events above the background, whose width is consistent with being entirely due to the experimental resolution. Under the selections based on a simulation of K+Xe collisions, the statistical significance of the signal reaches 5.5σ. We interpret this observation as strong evidence for formation of a pentaquark baryon with positive strangeness, Θ+(uudds¯), in the charge-exchange reaction K+n→K0p on a bound neutron. The mass of the Θ+ baryon is measured as m (Θ+)=1538±2 MeV. Using the ratio between the numbers of resonant and nonresonant charge-exchange events in the peak region, the intrinsic width of this baryon resonance is determined as Γ (Θ+)=0.34±0.10 MeV.

  17. Θ+ baryon, N* (1685) resonance, and πN sigma term reexamined within the framework of a chiral soliton model

    NASA Astrophysics Data System (ADS)

    Yang, Ghil-Seok; Kim, Hyun-Chul

    2013-01-01

    We reexamine the properties of the baryon antidecuplet Θ+ and N*, and the πN sigma term within the framework of a chiral soliton model, focusing on their dependence on the Θ+ mass. It turns out that the measured value of the N* mass, MN* = 1686 MeV, is consistent with that of the Θ+ mass MΘ+ = 1524 MeV by the LEPS collaboration [T. Nakano et al. [LEPS Collaboration], Phys. Rev. C 79, 025210 (2009)]. The N*→Nγ magnetic transition moments are almost independent of the Θ+ mass. The ratio of the radiative decay width Γnn* to Γpp* turns out to be around 5. The decay width for Θ+→NK is studied in the context of the LEPS and DIANA experiments. When the LEPS value of the Θ+ mass is employed, we obtain ΓΘNK = (0.5 ± 0.1) MeV. The πN sigma term is found to be almost independent of the Θ+ mass. In addition, we derive a new expression for the πN sigma term in terms of the isospin mass splittings of the hyperon octet as well as that of the antidecuplet N*.

  18. Neutron background characterization of deep underground laboratories

    NASA Astrophysics Data System (ADS)

    Best, Andreas; Görres, Joachim; Long, Alex; Smith, Karl; Stech, Ed; Wiescher, Michael

    2012-10-01

    Low-energy (,) reactions in stellar helium and carbon burning provide the neutrons for the formation of elements beyond iron by the slow neutron capture process. The very low cross sections at stellar energies necessitate the use of high-efficiency detectors as well as measuring in a very low neutron background environment. By going deep underground the neutron flux can be reduced by orders of magnitude compared to surface levels, enabling the measurement of reactions for nuclear astrophysics at previously inaccessible energies. The remaining neutron flux is mostly due to spontaneous fission of ^238U in the cavity walls and (,) reactions induced by α-particles from the natural radioactivity of the underground environment. Using a portable setup consisting of 4 ^3He counters and polyethylene moderators the DIANA collaboration is conducting neutron background measurements at various deep underground laboratories in the US. We present first results from the Kimballton Underground Research Facility, the Soudan Underground Laboratory and the 4100 feet level of the Sanford Undeground Research Facility (SURF). Measurements at other depths in SURF and at the Waste Isolation Pilot Plant are in planning.

  19. Assessment of damage localization based on spatial filters using numerical crack propagation models

    NASA Astrophysics Data System (ADS)

    Deraemaeker, Arnaud

    2011-07-01

    This paper is concerned with vibration based structural health monitoring with a focus on non-model based damage localization. The type of damage investigated is cracking of concrete structures due to the loss of prestress. In previous works, an automated method based on spatial filtering techniques applied to large dynamic strain sensor networks has been proposed and tested using data from numerical simulations. In the simulations, simplified representations of cracks (such as a reduced Young's modulus) have been used. While this gives the general trend for global properties such as eigen frequencies, the change of more local features, such as strains, is not adequately represented. Instead, crack propagation models should be used. In this study, a first attempt is made in this direction for concrete structures (quasi brittle material with softening laws) using crack-band models implemented in the commercial software DIANA. The strategy consists in performing a non-linear computation which leads to cracking of the concrete, followed by a dynamic analysis. The dynamic response is then used as the input to the previously designed damage localization system in order to assess its performances. The approach is illustrated on a simply supported beam modeled with 2D plane stress elements.

  20. New 1π sr acceptance angle display-type ellipsoidal mesh analyzer for electron energy and two-dimensional angular distribution as well as imaging analysis

    NASA Astrophysics Data System (ADS)

    Tóth, László; Goto, Kentaro; Matsuda, Hiroyuki; Matsui, Fumihiko; Daimon, Hiroshi

    2011-08-01

    We propose a Display-type Ellipsoidal Mesh Analyzer (DELMA) using a newly developed 1π sr wide acceptance angle electrostatic lens (WAAEL), energy aperture and some other electrostatic lenses [1-5]. It can display two-dimensional angular distributions of charged particles within the acceptance angle of ±60°, which is much larger than the largest acceptance angle range so far and comparable to the display-type spherical mirror analyzer (DIANA) developed by Daimon et al. [6,8-11]. It also has a focusing capability with 5 times magnification and ˜30 μm lateral resolution. The relative energy resolution is typically from 2 to 5×10-3 depending on the emission area of the sample, as well as on the diameter of energy aperture.Because this new analyzer has a function of low-magnification photoemission electron microscope, this instrument will be extended and applied as a new type Stereo-PEEM [7] in near future.

  1. [Gynecology and obstetrics in Ancient Rome].

    PubMed

    Dumont, M

    1992-10-01

    Gods and Goddesses were invoked by the Romans for the termination of a good delivery. Diana, Juno, Lucina and Cybele were the preferred ones. Sterility was sometimes treated by the whip of the Lupercali of ministers of Pan. The first doctors in Rome were coming from Greece. Celsus, Pliny the Elder were encyclopedists, Rufus an anatomist, Dioscorides a pharmacologist. Archigenes, Aretaeus and Antyllus surgeons. Soranus from Ephesus, was the first to recommend podalic version. His works was a long time buried in a profound oblivion and discovered by scholars during the nineteenth century. Galen was looked as the most famous medical man after Hippocrates. During the Roman Empire of Occident (Byzantine Empire), Oribasius, Aurelianus Caelius, Moschion and above all Aetius and Paul of Aegina wrote many works which were many times plagiarized. Roman laws concerning public health were severe. Midwives took an important action in the care of pregnant women. Roman poets as Plautus, Terence, Lucilius, Catullus, Virgil, Tibullus, Ovid and Martial were many times concerned in their writings with gynecologic or obstetric subjects. Children were easily forsaken. Three Emperors, Trajan, Marcus-Aurelius and Alexander Severius, a writer, Aulu-Gelles, and a rhetor, Quintilian, took protection of them.

  2. [Neurological disorders and the blood-brain barrier. Strategies and limitations for drug delivery to the brain].

    PubMed

    Domínguez, Alazne; Álvarez, Antonia; Suárez-Merino, Blanca; Goñi-de-Cerio, Felipe

    2014-03-01

    Introduccion. La incidencia de enfermedades del sistema nervioso central (SNC) aumenta a causa del envejecimiento de la sociedad. Desgraciadamente, los tratamientos clasicos para tratarlas no resultan efectivos debido a la presencia de la barrera hematoencefalica. Objetivo. Abordar las propiedades de la barrera hematoencefalica que impiden el transporte de los farmacos al cerebro y las principales estrategias para tratar las afecciones neurologicas. Desarrollo. La barrera hematoencefalica esta compuesta principalmente por un endotelio vascular especializado y las celulas de la glia. Esta constituye una herramienta a disposicion del organismo para aislar al SNC del resto del cuerpo. Sin embargo, tambien supone un impedimento para que muchos farmacos alcancen su diana en el cerebro. Conclusiones. Para poder tratar las afecciones neurologicas, los farmacos deben ser capaces de alcanzar el cerebro. Los agentes terapeuticos pueden diseñarse para que sean capaces de atravesar esta barrera, o bien facilitar su entrada mediante el uso de sistemas de liberacion. Para evaluar la efectividad de los tratamientos dirigidos a enfermedades del SNC, se emplean los modelos animales de enfermedades neurologicas asi como modelos in vitro de barrera hematoencefalica.

  3. Cloning and expression of sesquiterpene synthase genes from lettuce (Lactuca sativa L.).

    PubMed

    Bennett, Mark H; Mansfield, John W; Lewis, Mervyn J; Beale, Michael H

    2002-06-01

    Sesquiterpenoid lactones (SLs) from lettuce (Lactuca sativa L.) include constitutive components of latex such as lactucin and the induced phytoalexin, lettucenin A. A redundant primer strategy was used to recover two full length cDNA clones (LTC1 and LTC2) encoding sesquiterpene synthases from a cDNA library derived from seedlings with the red spot disorder, which accumulate phytoalexins. Recombinant enzymes produced from LTC1 and LTC2 in Escherichia coli catalysed the cyclisation of farnesyl diphosphate to germacrene A, potentially an early step in the biosynthesis of SLs. RT-PCR analysis showed LTC1 and LTC2 were expressed constitutively in roots, hypocotyls and true leaves but not in cotyledons. Expression in cotyledons was induced by challenge with the downy mildew pathogen Bremia lactucae in the disease resistant cultivar Diana. Southern hybridisation experiments showed that LTC1 and LTC2 were not part of a multigene family. The germacrene A synthases provide targets for modified expression to generate beneficial modifications to the SL profile in lettuce. PMID:12031443

  4. Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

    PubMed Central

    Gui, YaXing; Liu, Hai; Zhang, LiShan; Lv, Wen; Hu, XingYue

    2015-01-01

    The differential diagnosis of Parkinson's diseases (PD) is challenging, especially in the early stages of the disease. We developed a microRNA profiling strategy for exosomal miRNAs isolated from cerebrospinal fluid (CSF) in PD and AD. Sixteen exosomal miRNAs were up regulated and 11 miRNAs were under regulated significantly in PD CSF when compared with those in healthy controls (relative fold > 2, p < 0.05). MiR-1 and miR-19b-3p were validated and significantly reduced in independent samples. While miR-153, miR-409-3p, miR-10a-5p, and let-7g-3p were significantly over expressed in PD CSF exosome. Bioinformatic analysis by DIANA-mirPath demonstrated that Neurotrophin signaling, mTOR signaling, Ubiquitin mediated proteolysis, Dopaminergic synapse, and Glutamatergic synapse were the most prominent pathways enriched in quantiles with PD miRNA patterns. Messenger RNA (mRNA) transcripts [amyloid precursor protein, APP), α-synuclein (α-syn), Tau, neurofilament, light gene (NF-L), DJ-1/PARK7, Fractalkine and Neurosin] and long non-coding RNAs (RP11-462G22.1 and PCA3) were differentially expressed in CSF exosomes in PD and AD patients. These data demonstrated that CSF exosomal RNA molecules are reliable biomarkers with fair robustness in regard to specificity and sensitivity in differentiating PD from healthy and diseased (AD) controls. PMID:26497684

  5. Stardial -- an autonomous astronomical camera on the WWW

    NASA Astrophysics Data System (ADS)

    McCullough, P. R.; Thakkar, U.

    1997-05-01

    The use of an autonomous electronic camera, called ``Stardial,'' for undergraduate instruction is described. Stardial delivers images of the night sky nearly in real-time to the world wide web (www.astro.uiuc.edu/stardial/). The remote instrumentation of Stardial is robust, inexpensive, and accomodates many students asynchronously with respect to the instructor(s). The guiding philosophy of the curriculum is to provide students with authentic astronomical data so that they may learn about science by doing it themselves on the internet. Students respond favorably to the opportunity to learn from their own experiences with genuine data, complete with its irregularities and its surprises. Perhaps surprisingly, 9 of 10 self-selected student volunteers in our pilot project were female. Stardial's instrumentation is similar to that of Gaustad et al., and to that of Richmond, Droege, et al. (both at this same meeting). Stardial has benefitted from contributions from students, especially Lawrence Tan, Troy Klyber, Jim Pulokas, Jim Waldemer, and Diana Lopez, and from a number of professionals, especially G.T. Becker, Mike Newberry, John Dolby, Tom Droege, Bob Mutel, Mike Richmond, John Thorstensen, and Rick White. Stardial is funded by the University of Illinois, primarily from the office of the Vice President for Academic Affairs. We welcome participation from amateur astronomers and other educators.

  6. In Situ Boundary Layer Coral Metabolism in the Atlantic Ocean Acidification Test Bed

    NASA Astrophysics Data System (ADS)

    McGillis, Wade

    2013-04-01

    and Chris Langdon, Brice Loose, Dwight Gledhill, Diana Hsueh, Derek Manzello, Ian Enochs, Ryan Moyer We present net ecosystem productivity (nep) and net ecosystem calcification (nec) in coral and seagrass ecosystems using the boundary layer gradient flux technique (CROSS). Coastal anthropogenic inputs and changes in global ocean chemistry in response to rising levels of atmospheric carbon dioxide has emerged in recent years as a topic of considerable concern. Coral reefs are particularly vulnerable from eroded environmental conditions including ocean acidification and water pollution. The Atlantic Ocean Acidification Testbed (AOAT) project monitors metabolism to ascertain the continuing health of coral reef ecosystems. The CROSS boundary layer nep/nec approach is one component of this diagnostic program. Certification of CROSS as an operational monitoring tool is underway in the AOAT. CROSS inspects a benthic community and measures productivity/respiration and calcification/dissolution over an area of 10 square meters. Being a boundary layer tool, advection and complex mesoscale flows are not a factor or concern and CROSS is autonomous and can be used at deep benthic sites. The interrogation area is not enclosed therefore exposed to ambient light, flow, and nutrient levels. CROSS is easy to deploy, unambiguous, and affordable. Repeated measurements have been made from 2011-2012 in reefal systems in La Parguera Puerto Rico and the Florida Keys, USA. Diurnal, seasonal and regional metabolism will be compared and discussed. The ability to accurately probe benthic ecosystems provides a powerful management and research tool to policy makers and researchers.

  7. Analysis of direct-drive capsule compression experiments on the Iskra-5 laser facility

    NASA Astrophysics Data System (ADS)

    Gus'kov, S. Yu.; Demchenko, N. N.; Zhidkov, N. V.; Zmitrenko, N. V.; Litvin, D. N.; Rozanov, V. B.; Stepanov, R. V.; Suslov, N. A.; Yakhin, R. A.

    2010-09-01

    We have analyzed and numerically simulated our experiments on the compression of DT-gas-filled glass capsules under irradiation by a small number of beams on the Iskra-5 facility (12 beams) at the second harmonic of an iodine laser (λ = 0.66 μm) for a laser pulse energy of 2 kJ and duration of 0.5 ns in the case of asymmetric irradiation and compression. Our simulations include the construction of a target illumination map and a histogram of the target surface illumination distribution; 1D capsule compression simulations based on the DIANA code corresponding to various target surface regions; and 2D compression simulations based on the NUTCY code corresponding to the illumination conditions. We have succeeded in reproducing the shape of the compressed region at the time of maximum compression and the reduction in neutron yield (compared to the 1D simulations) to the experimentally observed values. For the Iskra-5 conditions, we have considered targets that can provide a more symmetric compression and a higher neutron yield.

  8. Picasso Paintings, Moon Rocks, and Hand-Written Beatles Lyrics: Adults’ Evaluations of Authentic Objects

    PubMed Central

    Frazier, Brandy N.; Gelman, Susan A.; Wilson, Alice; Hood, Bruce

    2010-01-01

    Authentic objects are those that have an historical link to a person, event, time, or place of some significance (e.g., original Picasso painting; gown worn by Princess Diana; your favorite baby blanket). The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults’ evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person’s attachment history (i.e., whether or not they owned an attachment object as a child) predicts evaluation of authentic objects. We found that college students in the U.K. (N = 125) and U.S. (N = 119) consistently evaluate a broad range of authentic items as more valuable than matched control (inauthentic) objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults. PMID:20631919

  9. [Cognitive reserve in substance addicts in treatment: relation to cognitive performance and activities of daily living].

    PubMed

    Pedrero-Pérez, Eduardo J; Rojo-Mota, Gloria; Ruiz-Sánchez de León, José M; Fernández-Méndez, Laura M; Morales-Alonso, Sara; Prieto-Hidalgo, Ana

    2014-12-01

    Introduccion. El concepto de reserva cognitiva ha ido ganando interes en la medida en que se ha acumulado evidencia sobre su relacion con la resistencia del cerebro a declinar en su funcionamiento ante amenazas o alteraciones neurologicas. Aunque se ha estudiado en un gran numero de alteraciones (degenerativas, traumaticas, psicopatologicas), pocos trabajos relacionan la reserva cognitiva con la adiccion a sustancias, un proceso multidimensional con clara base neurologica. Objetivo. Explorar la reserva cognitiva de pacientes en tratamiento por adiccion a drogas, relacionandolo con su rendimiento cognitivo en pruebas neuropsicologicas y en actividades de la vida diaria. Pacientes y metodos. Muestra de 57 pacientes en tratamiento por adiccion a sustancias en un centro especifico. Se administraron el cuestionario de reserva cognitiva, la evaluacion cognitiva de Montreal y el inventario de sintomas prefrontales, y se recogieron variables relacionadas con la adiccion. Resultados. Se encontro una relacion positiva entre la reserva cognitiva y el tiempo de abstinencia, y negativa con la gravedad de la adiccion. Aparecieron diferencias significativas segun la reserva cognitiva en rendimiento neuropsicologico (especialmente en ciertos dominios cognitivos) y en actividades cotidianas. Conclusiones. La reserva cognitiva aparece como una variable relacionada con la adiccion y los deficits cognitivos que la acompañan; resulta ser una potencial diana de las actividades rehabilitadoras, vinculada al paradigma de enriquecimiento ambiental, como estrategia para potenciar la resistencia frente al deterioro cognitivo que favorece y mantiene la adiccion y para disminuir el potencial reforzador de la conducta de consumo.

  10. MicroRNA regulation in heart and skeletal muscle over the freeze-thaw cycle in the freeze tolerant wood frog.

    PubMed

    Bansal, Saumya; Luu, Bryan E; Storey, Kenneth B

    2016-02-01

    The North American wood frog, Rana sylvatica, is one of just a few anuran species that tolerates whole body freezing during the winter and has been intensely studied to identify the biochemical adaptations that support freeze tolerance. Among these adaptations is the altered expression of many genes, making freeze-responsive changes to gene regulatory mechanisms a topic of interest. The present study focuses on the potential involvement of microRNAs as one such regulatory mechanism and aims to better understand freeze/thaw stress-induced microRNA responses in the freeze-tolerant wood frog. Using quantitative PCR, relative levels of 53 microRNAs were measured in heart and skeletal muscle of control, 24 h frozen, and 8 h thawed frogs. MicroRNAs showed tissue specific expression patterns: 21 microRNAs decreased in the heart during thawing, whereas 16 microRNAs increased during freezing stress in skeletal muscle. These findings suggest that select genes may be activated and suppressed in heart and skeletal muscle, respectively, in response to freezing. Bioinformatics analysis using the DIANA miRPath program (v.2.0) predicted that the differentially expressed microRNAs may collectively regulate tissue-specific cellular pathways to promote survival of wood frogs undergoing freezing and thawing.

  11. Long Term Effects of Reclaimed Water on Rose and Carnation Cut Flower Crops in Soil and Soilless Media

    NASA Astrophysics Data System (ADS)

    Safi, M. I.; Fardous, A.; Muddaber, M.; El-Zuraiqi, S.; Balaweneh, A.; Al-Hadidi, L.; Bashabsheh, I.

    The effect of three irrigation regimes of low quality water (the effluent of reclaimed wastewater from Ramtha treating plant) on soil, drained water and plant tissue chemical composition of First Red cut flower rose cultivar grown on three rootstocks Rosa indica, Rosa canina and Natal Briar and three carnation cultivars 'Voyore, Diana and Chad' was investigated in two separate experiments for two successive years 2003 and 2004 in two planting media soil and Zeotuff. After two years of growing roses and carnations in soil using reclaimed wastewater for irrigation, Ca reached intermediate concentrations, Mg very highly accumulated, Na showed high levels, P showed low levels, while K was very highly accumulated in both soil depths. Mn, Cu and Zn showed no accumulation in soil, Fe reached high levels in both years of irrigation in the two depths. According to the optimum nutrient's levels in rose tissue declared by the literature, the only macro and micro element's accumulation was recorded for Sodium in the tissue of first red rose planted in both media during both years and Iron in both media during the first year only, regardless of water treatment. While it was recorded for Mg in the tissue of carnations regardless of cultivar in tuff medium during both years and Fe in both media during the first year only, regardless of water treatment.

  12. Beyond offshoring: assess your company's global potential.

    PubMed

    Farrell, Diana

    2004-12-01

    In the past few years, companies have become aware that they can slash costs by offshoring: moving jobs to lower-wage locations. But this practice is just the tip of the iceberg in terms of how globalization can transform industries, according to research by the McKinsey Global Institute (MGI). The institute's yearlong study suggests that by streamlining their production processes and supply chains globally, rather than just nationally or regionally, companies can lower their costs-as we've seen in the consumer-electronics and PC industries. Companies can save as much as 70% of their total costs through globalization--50% from offshoring, 5% from training and business-task redesign, and 15% from process improvements. But they don't have to stop there. The cost reductions make it possible to lower prices and expand into new markets, attracting whole new classes of customers. To date, however, few businesses have recognized the full scope of performance improvements that globalization makes possible, much less developed sound strategies for capturing those opportunities. In this article, Diana Farrell, director of MGI, offers a step-by-step approach to doing both things. Among her suggestions: Assess where your industry falls along the globalization spectrum, because not all sectors of the economy face the same challenges and opportunities at the same time. Also, pay attention to production, regulatory, and organizational barriers to globalization. If any of these can be changed, size up the cost-saving (and revenue-generating) opportunities that will emerge for your company as a result of those changes. Farrell also defines the five stages of globalization-market entry, product specialization, value chain disaggregation, value chain reengineering, and the creation of new markets-and notes the different levers for cutting costs and creating value that companies can use in each phase. PMID:15605568

  13. The real new economy.

    PubMed

    Farrell, Diana

    2003-10-01

    During the soar-and-swoon days of the late 1990s, many people believed that information technology, and the Internet in particular, were "changing everything" in business. A fundamental change did happen in the 1990s, but it was less about technology than about competition. Under director Diana Farrell, the McKinsey Global Institute has conducted an extensive study of productivity and its connection to corporate IT spending and use during that period. The study revealed that information technology is important--but not central--to the fate of industries and individual companies. So if information technology was not the primary factor in the productivity surge, what was? The study points to competition and innovation. In those industries that saw increases in competitive intensity, managers were forced to innovate aggressively to protect their revenues and profits. Those innovations--in products, business practices, and technology--led to the gains in productivity. In fact, a critical dynamic of the new economy--the real new economy--is the virtuous cycle of competition, innovation, and productivity growth. Managers can innovate in many ways, but during the 1990s, information technology was a particularly powerful tool, for three reasons: First, IT enabled the development of attractive new products and efficient new business processes. Second, it facilitated the rapid industrywide diffusion of innovations. And third, it exhibited strong scale economies--its benefits multiplied rapidly as its use expanded. This article reveals surprising data on how various industries in the United States and Europe were affected by competition, innovation, and information technology in the 1990s and offers insights about how managers can get more from their IT investments.

  14. Pricing products: juxtaposing affordability with quality appeal.

    PubMed

    1984-01-01

    Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing

  15. An atlas of type I MADS box gene expression during female gametophyte and seed development in Arabidopsis.

    PubMed

    Bemer, Marian; Heijmans, Klaas; Airoldi, Chiara; Davies, Brendan; Angenent, Gerco C

    2010-09-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally characterized, which revealed important roles for these genes during female gametophyte and early seed development. The functions of the other genes are still unknown, despite the fact that the available single T-DNA insertion mutants have been largely investigated. The lack of mutant phenotypes is likely due to a considerable number of recent intrachromosomal duplications in the type I subfamily, resulting in nonfunctional genes in addition to a high level of redundancy. To enable a breakthrough in type I MADS box gene characterization, a framework needs to be established that allows the prediction of the functionality and redundancy of the type I genes. Here, we present a complete atlas of their expression patterns during female gametophyte and seed development in Arabidopsis, deduced from reporter lines containing translational fusions of the genes to green fluorescent protein and beta-glucuronidase. All the expressed genes were revealed to be active in the female gametophyte or developing seed, indicating that the entire type I subfamily is involved in reproductive development in Arabidopsis. Interestingly, expression was predominantly observed in the central cell, antipodal cells, and chalazal endosperm. The combination of our expression results with phylogenetic and protein interaction data allows a better identification of putative redundantly acting genes and provides a useful tool for the functional characterization of the type I MADS box genes in Arabidopsis.

  16. An Atlas of Type I MADS Box Gene Expression during Female Gametophyte and Seed Development in Arabidopsis[W

    PubMed Central

    Bemer, Marian; Heijmans, Klaas; Airoldi, Chiara; Davies, Brendan; Angenent, Gerco C.

    2010-01-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally characterized, which revealed important roles for these genes during female gametophyte and early seed development. The functions of the other genes are still unknown, despite the fact that the available single T-DNA insertion mutants have been largely investigated. The lack of mutant phenotypes is likely due to a considerable number of recent intrachromosomal duplications in the type I subfamily, resulting in nonfunctional genes in addition to a high level of redundancy. To enable a breakthrough in type I MADS box gene characterization, a framework needs to be established that allows the prediction of the functionality and redundancy of the type I genes. Here, we present a complete atlas of their expression patterns during female gametophyte and seed development in Arabidopsis, deduced from reporter lines containing translational fusions of the genes to green fluorescent protein and β-glucuronidase. All the expressed genes were revealed to be active in the female gametophyte or developing seed, indicating that the entire type I subfamily is involved in reproductive development in Arabidopsis. Interestingly, expression was predominantly observed in the central cell, antipodal cells, and chalazal endosperm. The combination of our expression results with phylogenetic and protein interaction data allows a better identification of putative redundantly acting genes and provides a useful tool for the functional characterization of the type I MADS box genes in Arabidopsis. PMID:20631316

  17. Science Planning for the TROPIX Mission

    NASA Technical Reports Server (NTRS)

    Russell, C. T.

    1998-01-01

    The objective of the study grant was to undertake the planning needed to execute meaningful solar electric propulsion missions in the magnetosphere and beyond. The first mission examined was the Transfer Orbit Plasma Investigation Experiment (TROPIX) mission to spiral outward through the magnetosphere. The next mission examined was to the moon and an asteroid. Entitled Diana, it was proposed to NASA in October 1994. Two similar missions were conceived in 1996 entitled CNR for Comet Nucleus Rendezvous and MBAR for Main Belt Asteroid Rendezvous. The latter mission was again proposed in 1998. All four of these missions were unsuccessfully proposed to the NASA Discovery program. Nevertheless we were partially successful in that the Deep Space 1 (DS1) mission was eventually carried out nearly duplicating our CNR mission. Returning to the magnetosphere we studied and proposed to the Medium Class Explorer (MIDEX) program a MidEx mission called TEMPEST, in 1995. This mission included two solar electric spacecraft that spiraled outward in the magnetosphere: one at near 900 inclination and one in the equatorial plane. This mission was not selected for flight. Next we proposed a single SEP vehicle to carry Energetic Neutral Atom (ENA) imagers and inside observations to complement the IMAGE mission providing needed data to properly interpret the IMAGE data. This mission called SESAME was submitted unsuccessfully in 1997. One proposal was successful. A study grant was awarded to examine a four spacecraft solar electric mission, named Global Magnetospheric Dynamics. This study was completed and a report on this mission is attached but events overtook this design and a separate study team was selected to design a classical chemical mission as a Solar Terrestrial Probe. Competing proposals such as through the MIDEX opportunity were expressly forbidden. A bibliography is attached.

  18. CrossHub: a tool for multi-way analysis of The Cancer Genome Atlas (TCGA) in the context of gene expression regulation mechanisms

    PubMed Central

    Krasnov, George S.; Dmitriev, Alexey A.; Melnikova, Nataliya V.; Zaretsky, Andrew R.; Nasedkina, Tatiana V.; Zasedatelev, Alexander S.; Senchenko, Vera N.; Kudryavtseva, Anna V.

    2016-01-01

    The contribution of different mechanisms to the regulation of gene expression varies for different tissues and tumors. Complementation of predicted mRNA–miRNA and gene–transcription factor (TF) relationships with the results of expression correlation analyses derived for specific tumor types outlines the interactions with functional impact in the current biomaterial. We developed CrossHub software, which enables two-way identification of most possible TF–gene interactions: on the basis of ENCODE ChIP-Seq binding evidence or Jaspar prediction and co-expression according to the data of The Cancer Genome Atlas (TCGA) project, the largest cancer omics resource. Similarly, CrossHub identifies mRNA–miRNA pairs with predicted or validated binding sites (TargetScan, mirSVR, PicTar, DIANA microT, miRTarBase) and strong negative expression correlations. We observed partial consistency between ChIP-Seq or miRNA target predictions and gene–TF/miRNA co-expression, demonstrating a link between these indicators. Additionally, CrossHub expression-methylation correlation analysis can be used to identify hypermethylated CpG sites or regions with the greatest potential impact on gene expression. Thus, CrossHub is capable of outlining molecular portraits of a specific gene and determining the three most common sources of expression regulation: promoter/enhancer methylation, miRNA interference and TF-mediated activation or repression. CrossHub generates formatted Excel workbooks with the detailed results. CrossHub is freely available at https://sourceforge.net/projects/crosshub/. PMID:26773058

  19. PREFACE: 17th International School on Condensed Matter Physics (ISCMP): Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications

    NASA Astrophysics Data System (ADS)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Pecheva, Emilia; Petrov, Alexander G.; Primatarowa, Marina T.

    2012-12-01

    We are pleased to introduce the Proceedings of the 17th International School on Condensed Matter Physics: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. Like prior events, the School took place in the beautiful Black Sea resort of Saints Constantine and Helena near Varna, going back to the refurbished facilities of the Panorama hotel. Participants from 17 different countries delivered 31 invited lecturers and 78 posters, contributing through three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the accepted papers illustrate the diversity and the high level of the contributions. Not least significant factor for the success of the 17 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. Visits to the Archaeological Museum (rich in valuable gold treasures of the ancient Thracian culture) and to the famous rock monastery Aladja were organized for the participants from the Varna Municipality. These Proceedings are published for the second time by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for supporting this idea. The Committee decided that the next event will take place again in Saints Constantine and Helena, 1-5 September 2014. It will be entitled: Challenges of the Nanoscale Science: Theory, Materials and Applications. Doriana Dimova-Malinovska, Diana Nesheva, Emilia Pecheva, Alexander G Petrov and Marina T Primatarowa Editors

  20. Bovine hypodermosis--a global aspect.

    PubMed

    Hassan, Murtaz-ul; Khan, Muhammad Nisar; Abubakar, Muhammad; Waheed, Hafiz Muhammad; Iqbal, Zafar; Hussain, Manzoor

    2010-12-01

    Cattle hypodermosis (warble fly infestation) is a notorious veterinary problem throughout the world. Larvae of Hypoderma species cause a subcutaneous myiasis of domesticated and wild ruminants. This disease is caused by, Hypoderma bovis, Hypoderma lineatum in cattle whereas, Hypoderma diana, Hypoderma actaeon, and Hypoderma tarandi, affect roe deer, red deer, and reindeer, respectively. Adults of the cattle grub are commonly known as heel flies, warble flies, bomb flies or gad flies. The biology of hypodermosis is complex because it passes through ecto- as well as endoparasitic stages in the life cycle. The parasitic stage of hypodermosis lasts about 1 year in domesticated as well as in the wild animals, while in the adult stage, a free-living fly lasts only for few days. The diagnosis of hypodermosis is of prime importance for planning treatment and the eradication program. Generally, there are two methods that are routinely used for diagnosis of hypodermosis, i.e., the direct clinical examination and immuno diagnosis by the use of pooled serum and/or milk sample. For the control of hypodermosis, different preparations are available and their use in most of the countries is limited to an individual level but never cover the whole cattle population of a country. Re-infestation in the herd occurs due to the untreated animals that remain the reservoir of the disease. The disease causes huge economic losses in animal production due to the effect of this disease on meat, milk, and the leather industry. It can also affect the general health status as well as the immune system of the body of the diseased animals. As regards the control measures of the disease, different methods have been efficiently practiced and consequently this disease is controlled at national level in many European countries. PMID:20607401

  1. NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.

    PubMed Central

    Szyperski, T; Pellecchia, M; Wall, D; Georgopoulos, C; Wüthrich, K

    1994-01-01

    DnaJ from Escherichia coli is a 376-amino acid protein that functions in conjunction with DnaK and GrpE as a chaperone machine. The N-terminal fragment of residues 2-108, DnaJ-(2-108), retains many of the activities of the full-length protein and contains a structural motif, the J domain of residues 2-72, which is highly conserved in a superfamily of proteins. In this paper, NMR spectroscopy was used to determine the secondary structure and the three-dimensional polypeptide backbone fold of DnaJ-(2-108). By using 13C/15N doubly labeled DnaJ-(2-108), nearly complete sequence-specific assignments were obtained for 1H, 15N, 13C alpha, and 13C beta, and about 40% of the peripheral aliphatic carbon resonances were also assigned. Four alpha-helices in polypeptide segments of residues 6-11, 18-31, 41-55, and 61-68 in the J domain were identified by sequential and medium-range nuclear Overhauser effects. For the J domain, the three-dimensional structure was calculated with the program DIANA from an input of 536 nuclear Overhauser effect upper-distance constraints and 52 spin-spin coupling constants. The polypeptide backbone fold is characterized by the formation of an antiparallel bundle of two long helices, residues 18-31 and 41-55, which is stabilized by a hydrophobic core of side chains that are highly conserved in homologous J domain sequences. The Gly/Phe-rich region from residues 77 to 108 is flexibly disordered in solution. Images PMID:7972061

  2. Distinct microRNA expression signatures in human right atrial and ventricular myocardium.

    PubMed

    Zhang, Yangyang; Wang, Xiaowei; Xu, Xiaohan; Wang, Jun; Liu, Xiang; Chen, Yijiang

    2012-12-01

    Human atrial and ventricular myocardium has distinct structure and physiology. MicroRNAs (miRNAs) are the central players in the regulation of gene expression, participating in many physiological processes. A comprehensive knowledge of miRNA expression in the human heart is essential for the understanding of myocardial function. The aim of this study was to compare the miRNA signature in human right atrial and ventricular myocardium. Agilent human miRNA arrays were used to indicate the miRNA expression signatures of the right atrial (n = 8) and ventricular (n = 9) myocardium of healthy individuals. Quantitative reverse transcription-polymerase chain reactions (qRT-PCRs) were used to validate the array results. DIANA-mirPath was used to incorporate the miRNAs into pathways. MiRNA arrays showed that 169 miRNAs were expressed at different levels in human right atrial and ventricular myocardium. The unsupervised hierarchical clustering analysis based on the 169 dysregulated miRNAs showed that miRNA expression categorized two well-defined clusters that corresponded to human right atrial and ventricular myocardium. The qRT-PCR results correlated well with the microarray data. Bioinformatic analysis indicated the potential miRNA targets and molecular pathways. This study indicates that distinct miRNA expression signatures in human right atrial and ventricular myocardium. The findings provide a novel understanding of the molecular differences between human atrial and ventricular myocardium and may establish a framework for an anatomically detailed evaluation of cardiac function regulation.

  3. MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways

    PubMed Central

    Artcibasova, Alina V.; Korzinkin, Mikhail B.; Sorokin, Maksim I.; Shegay, Peter V.; Zhavoronkov, Alex A.; Gaifullin, Nurshat; Alekseev, Boris Y.; Vorobyev, Nikolay V.; Kuzmin, Denis V.; Kaprin, Аndrey D.; Borisov, Nikolay M.; Buzdin, Anton A.

    2016-01-01

    ABSTRACT MicroRNAs (miRs) are short noncoding RNA molecules that regulate expression of target mRNAs. Many published sources provide information about miRs and their targets. However, bioinformatic tools elucidating higher level impact of the established total miR profiles, are still largely missing. Recently, we developed a method termed OncoFinder enabling quantification of the activities of intracellular molecular pathways basing on gene expression data. Here we propose a new technique, MiRImpact, which enables to link miR expression data with its estimated outcome on the regulation of molecular pathways, like signaling, metabolic, cytoskeleton rearrangement, and DNA repair pathways. MiRImpact uses OncoFinder rationale for pathway activity calculations, with the major distinctions that (i) it deals with the concentrations of miRs - known regulators of gene products participating in molecular pathways, and (ii) miRs are considered as negative regulators of target molecules, if other is not specified. MiRImpact operates with 2 types of databases: for molecular targets of miRs and for gene products participating in molecular pathways. We applied MiRImpact to compare regulation of human bladder cancer-specific signaling pathways at the levels of mRNA and miR expression. We took 2 most complete alternative databases of experimentally validated miR targets – miRTarBase and DianaTarBase, and an OncoFinder database featuring 2725 gene products and 271 signaling pathways. We showed that the impact of miRs is orthogonal to pathway regulation at the mRNA level, which stresses the importance of studying posttranscriptional regulation of gene expression. We also report characteristic set of miR and mRNA regulation features linked with bladder cancer. PMID:27027999

  4. How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study.

    PubMed

    Carotenuto, Felicia; Albertini, Maria C; Coletti, Dario; Vilmercati, Alessandra; Campanella, Luigi; Darzynkiewicz, Zbigniew; Teodori, Laura

    2016-01-01

    The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of DDR. Dietary bioactive compounds through miRs may affect activity of numerous genes. Among the most studied bioactive compounds modulating expression of miRs are epi-gallocatechin-3-gallate, curcumin, resveratrol and n3-polyunsaturated fatty acids. To compare the impact of these dietary compounds on DD/DDR network modulation, we performed a literature search and an in silico analysis by the DIANA-mirPathv3 software. The in silico analysis allowed us to identify pathways shared by different miRs involved in DD/DDR vis-à-vis the specific compounds. The results demonstrate that certain miRs (e.g., -146, -21) play a central role in the interplay among DD/DDR and the bioactive compounds. Furthermore, some specific pathways, such as "fatty acids biosynthesis/metabolism", "extracellular matrix-receptor interaction" and "signaling regulating the pluripotency of stem cells", appear to be targeted by most miRs affected by the studied compounds. Since DD/DDR and these pathways are strongly related to aging and carcinogenesis, the present in silico results of our study suggest that monitoring the induction of specific miRs may provide the means to assess the antiaging and chemopreventive properties of particular dietary compounds. PMID:27213347

  5. Effects of metal contamination in situ on osmoregulation and oxygen consumption in the mudflat fiddler crab Uca rapax (Ocypodidae, Brachyura).

    PubMed

    Capparelli, Mariana V; Abessa, Denis M; McNamara, John C

    2016-01-01

    The contamination of estuaries by metals can impose additional stresses on estuarine species, which may exhibit a limited capability to adjust their regulatory processes and maintain physiological homeostasis. The mudflat fiddler crab Uca rapax is a typical estuarine crab, abundant in both pristine and contaminated areas along the Atlantic coast of Brazil. This study evaluates osmotic and ionic regulatory ability and gill Na(+)/K(+)-ATPase activity in different salinities (<0.5, 25 and 60‰ S) and oxygen consumption rates at different temperatures (15, 25 and 35°C) in U. rapax collected from localities along the coast of São Paulo State showing different histories of metal contamination (most contaminated Ilha Diana, Santos>Rio Itapanhaú, Bertioga>Picinguaba, Ubatuba [pristine reference site]). Our findings show that the contamination of U. rapax by metals in situ leads to bioaccumulation and induces biochemical and physiological changes compared to crabs from the pristine locality. U. rapax from the contaminated sites exhibit stronger hyper- and hypo-osmotic regulatory abilities and show greater gill Na(+)/K(+)-ATPase activities than crabs from the pristine site, revealing that the underlying biochemical machinery can maintain systemic physiological processes functioning well. However, oxygen consumption, particularly at elevated temperatures, decreases in crabs showing high bioaccumulation titers but increases in crabs with low/moderate bioaccumulation levels. These data show that U. rapax chronically contaminated in situ exhibits compensatory biochemical and physiological adjustments, and reveal the importance of studies on organisms exposed to metals in situ, particularly estuarine invertebrates subject to frequent changes in natural environmental parameters like salinity and temperature.

  6. Experimental search for radiative decays of the pentaquark baryon {Theta}{sup +}(1540)

    SciTech Connect

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tumanov, G. K.; Verebryusov, V. S.

    2010-07-15

    The data on the reactions K{sup +}Xe {sup {yields}}K{sup 0{gamma}}X and K{sup +}Xe {sup {yields}}K{sup +{gamma}}X, obtained with the bubble chamber DIANA, have been analyzed for possible radiative decays of the {Theta}{sup +}(1540) baryon: {Theta}{sup +} {sup {yields}}K{sup 0}p{gamma} and {Theta}{sup +} {sup {yields}}K{sup +}n{gamma}. No signals have been observed, and we derive the upper limits {Gamma}({Theta}{sup +} {sup {yields}}K{sup 0}p{gamma})/{Gamma}({Theta}{sup +} {sup {yields}}K{sup 0}p) < 0.032 and {Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma})/{Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma}) < 0.041 which, using our previous measurement of {Gamma}({Theta}{sup +} {sup {yields}}KN) = 0.39 {+-} 0.10 MeV, translate to {Gamma}({Theta}{sup +} {sup {yields}}K{sup 0}p{gamma}) < 8 keV and {Gamma}({Theta}{sup +} {sup {yields}}K{sup +}n{gamma}) < 11 keV at 90% confidence level. We have also measured the cross sections of K{sup +}-induced reactions involving emission of a neutral pion: {sigma}(K{sup +}n {sup {yields}}K{sup 0}p{pi}{sup 0}) = 68 {+-} 18 {mu}b and {sigma}(K{sup +}N {sup {yields}}K{sup +}N{pi}{sup 0}) = 30 {+-} 8 {mu}b for incident K{sup +} momentum of 640 MeV.

  7. U-Pb garnet, sphene, monazite, and rutile ages: Implications for the duration of high-grade metamorphism and cooling histories, Adirondack Mts. , New York

    SciTech Connect

    Mezger, K.; Rawnsley, C.M.; Hanson, G.N. ); Bohlen, S.R. )

    1991-05-01

    Garnet ages for the Lowlands range from 1,168-1,127 Ma, those from the central and southern Highlands from 1,154-1,013 Ma. Metamorphism in the Highlands may not have occurred as a single event but rather in several discrete thermal pulses. An age of 1,153 {plus minus} 3 Ma was determined for garnets in the syn-regional metamorphic contact aureole of the Diana syenite, consistent with that of the syenite intrusion, 1 155 {plus minus} 4 Ma. Garnets just outside the contact aureole give an age of 1,168 {plus minus} 6 Ma. In the Lowlands, monazite yielded an age of 1,161 {plus minus} 1 Ma, rutiles yielded ages of 1,005 {plus minus} 2 Ma and 953 {plus minus} 4 Ma, and sphene ages range from 1,156 to 1,103 Ma. In the Highlands, monazite yielded an age of 1,033 {plus minus} 1 Ma, rutiles yielded ages of 911 {plus minus} 2 Ma and 885 {plus minus} 2 and sphenes from 1,033 Ma to 991 Ma. The rutile and monazite ages indicate that both terranes cooled at time-integrated rates of ca. 1.5C/Ma for at least 150 Ma following the last phase of high-grade metamorphism. The Lowlands cooled to ca. 400C by ca. 1,000 Ma and the Highlands by ca. 900 Ma. The mineral ages indicate that metamorphic pressures and temperatures recorded by thermobarometry correspond to conditions attained polychronically over 150 Ma or more. Mineral ages combined with temperature estimates for peak metamorphism indicate that the closure temperature for the U-Pb system is >800C in garnet, 640-730C in monazite, and 500-670C in sphene.

  8. PREFACE: 2nd International Conference on Innovative Materials, Structures and Technologies

    NASA Astrophysics Data System (ADS)

    Ručevskis, Sandris

    2015-11-01

    The 2nd International Conference on Innovative Materials, Structures and Technologies (IMST 2015) took place in Riga, Latvia from 30th September - 2nd October, 2015. The first event of the conference series, dedicated to the 150th anniversary of the Faculty of Civil Engineering of Riga Technical University, was held in 2013. Following the established tradition, the aim of the conference was to promote and discuss the latest results of industrial and academic research carried out in the following engineering fields: analysis and design of advanced structures and buildings; innovative, ecological and energy efficient building materials; maintenance, inspection and monitoring methods; construction technologies; structural management; sustainable and safe transport infrastructure; and geomatics and geotechnics. The conference provided an excellent opportunity for leading researchers, representatives of the industrial community, engineers, managers and students to share the latest achievements, discuss recent advances and highlight the current challenges. IMST 2015 attracted over 120 scientists from 24 countries. After rigorous reviewing, over 80 technical papers were accepted for publication in the conference proceedings. On behalf of the organizing committee I would like to thank all the speakers, authors, session chairs and reviewers for their efficient and timely effort. The 2nd International Conference on Innovative Materials, Structures and Technologies was organized by the Faculty of Civil Engineering of Riga Technical University with the support of the Latvia State Research Programme under the grant agreement "INNOVATIVE MATERIALS AND SMART TECHNOLOGIES FOR ENVIRONMENTAL SAFETY, IMATEH". I would like to express sincere gratitude to Juris Smirnovs, Dean of the Faculty of Civil Engineering, and Andris Chate, manager of the Latvia State Research Programme. Finally, I would like to thank all those who helped to make this event happen. Special thanks go to Diana

  9. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy.

    PubMed

    Ruiz Esparza-Garrido, Ruth; Torres-Márquez, María Eugenia; Viedma-Rodríguez, Rubí; Velázquez-Wong, Ana Claudia; Salamanca-Gómez, Fabio; Rosas-Vargas, Haydeé; Velázquez-Flores, Miguel Ángel

    2016-05-01

    B-cell lymphoma 2 (BCL2)-interacting killer (apoptosis inducing) (BIK) has been proposed as a tumor suppressor in diverse types of cancers. However, BIK's overexpression in breast cancer (BC) and in non-small lung cancer cells (NSCLCs), associated with a poor prognosis, suggests its participation in tumor progression. In this study, we evaluated the global expression pattern of microRNAs (miRNAs), messenger RNA (mRNA) expression changes in autophagy, and autophagic flux after BIK interference. BIK gene expression was silenced by small interfering RNA (siRNA) in BC cell MDA-MB-231, and BIK interference efficiency was tested by real-time PCR and by Western blotting. BIK expression levels decreased by 75 ± 18 % in the presence of 600 nM siRNA, resulting in the abolishment of BIK expression by 94 ± 30 %. BIK interference resulted in the overexpression of 17 miRNAs that, according to the DIANA-miRPath v3.0 database, are mainly implied in the control of cell signaling, gene expression, and autophagy. The autophagy array revealed downregulation of transcripts which participate in autophagy, and their interactome revealed a complex network, where hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), α-synuclein (SNCA), unc-51-like autophagy activating kinase 1/2 (ULK1/2), and mitogen-activated protein kinase 3 (MAPK3) were shown to be signaling hubs. LC3-II expression-an autophagy marker-was increased by 169 ± 25 % after BIK interference, which indicates the involvement of BIK in autophagy. Altogether, our results indicate-for the first time-that BIK controls the expression of miRNAs, as well as the autophagic flux in MDA-MB-231 cells. PMID:26662110

  10. Culturally relevant science: An approach to math science education for Hispanics. Final technical report

    SciTech Connect

    Ortiz de Montellano, B.

    1996-11-14

    As planned a letter was sent out to 17 teachers who had participated in a Summer 1994 workshop on ``Culturally Relevant Science for Hispanics`` at Michigan State. These teachers were supposed to have spent the intervening time developing lesson plans and curricula. The letter requested a report of any activities undertaken and copies of lesson plans and materials developed by February 1996 with a stipend of $400 for satisfactory reports. It was a disappointment to only get 9 responses and not all of them demonstrating a satisfactory level of activity. Diana Marinez, Dean of Science at Texas A and M University, Corpus Christi, who is the other developer of this curriculum and the author reviewed the submitted materials and chose those showing the most promise to be invited to participate in the Summer Writing Workshop. Spring of 1996 and particularly in May--June, the author wrote a partial first draft of a companion volume for the teacher`s manual which would provide a rationale for doing culturally relevant science, present the cultural and the scientific background that teachers would need in order to be able to teach. One of the goals of this curriculum is that it should be off-the-shelf ready to teach and that teachers would not have to do extra research to encourage its adoption. The outline of the book is appendix 1. The Writing Workshop was held at Texas A and M University, Corpus Christi from July 14 to July 27, 1996. Participating teachers chose topics that they were interested in developing and wrote first drafts. These were distributed to all participants and critiqued by the workshop directors before being rewritten. Some teachers were more productive than others depending on their science background. In total an impressive number of lesson plans were written. These lesson plans are listed in Appendix 3. Appendix 4 is a sample lesson. Work still needs to be done on both the source book and the teachers` manual.

  11. Synanthropy of sarcophagidae (Diptera) in La Pintada, Antioquia-Colombia.

    PubMed

    Yepes-Gaurisas, Daniela; Sánchez-Rodríguez, Juan David; de Mello-Patiu, Cátia Antunes; Wolff Echeverri, Marta

    2013-09-01

    Recently, populations of flies have increased in numbers given the elevated levels of organic matter waste produced by anthropic activities and domestication of animals. Such increase represents a worldwide health concern, since flies can be vectors of human diseases. The great variety of feeding and developmental habits of flies of the family Sarcophagidae taking place on animal corpses, feces and decomposed organic matter make them potential vectors of pathogens. Herein, we evaluated the synanthropic index (SI), as well as other ecological aspects of this family, through simultaneous monthly samplings in three areas with different degrees of human disturbance (urban, rural and forest). Each area had four van Someren Rydon traps, each one with a different bait (i.e., human feces, chicken viscera, fish and decomposing onion). Traps were active during 48 hours each month, and specimen collection was made every 12 hours. A total of 7 446 Sarcophagidae individuals were collected (1275 males and 6171 females), belonging to 27 species and nine genera. Tricharaea (Sarcophagula) canuta (Sl = +96.67), Oxysarcodexia taitensis (SI = +93.85), Peckia (Peckia) chrysostoma (SI = +90.00) and Tricharaea (Sarcophagula) occidua (SI = +88.76) exhibited the highest values of synanthropy index, revealing a strong preference for human settlements. The most abundant species were Oxysarcodexia conclausa (21.80%), Ravinia effrenata (18.67%), Oxysarcodexia bakeri (11.45%) and Oxysarcodexia taitensis (10.20%), all of which exhibited preference for urban environments. Additionally, we are reporting seven new records of Sarcophagid flies for Colombia: Oxysarcodexia angrensis, Oxysarcodexia bakeri, Oxysarcodexia diana, Oxysarcodexia similata, Oxysarcodexia timida, Peckia (Peckia) pexata and Titanogrypa (Cucullomyia) placida.

  12. Gulf of Mexico Gas Hydrate Joint Industry Project Leg II: Results from the Alaminos Canyon 21 Site

    NASA Astrophysics Data System (ADS)

    Godfriaux, P. D.; Shedd, W.; Frye, M.; Collett, T. S.; Lee, M. W.; Boswell, R. M.; Cook, A.; Mrozewski, S.; Guerin, G.; McConnell, D.; Dufrene, R.; Jones, E.

    2009-12-01

    The Gulf of Mexico Gas Hydrate Joint Industry Project Leg II drilling program visited three sites in the Gulf of Mexico during a 21 day drilling program in April and May, 2009. Using both petroleum systems and seismic stratigraphic approaches, the exploration focus for Leg II was to identify sites with the potential for gas hydrate-saturated sand reservoirs. Two holes were drilled at the AC 21 site in the Diana Basin located in the western Gulf of Mexico. The data acquired consist of a comprehensive suite of high resolution LWD logs including gamma ray, density, porosity, sonic, and resistivity tools. No physical samples were taken in the field. The primary objective of each well was to determine the presence or absence of gas hydrate from the log data at the predetermined primary targets in a Pleistocene basin floor turbidite complex approximately 500 ft below seafloor. At the AC 21-A location, two high net to gross target sands were encountered that measured 15 ft and 60 ft, respectively. The AC 21-A well was drilled through the interpreted base of gas hydrate stability to a depth approximately 1500 ft below sea floor. The AC 21-B well encountered a single high net to gross target sand measuring over 120 ft thick. At both AC 21 well locations, all target sand intervals had elevated formation resistivity measurements relative to clearly wet, stratigraphically equivalent sands encountered in the region, interpreted to indicate low to moderate levels of gas hydrate saturation. The likely discovery of thick gas hydrate-filled sands at the AC 21 site validates the exploration approach, and strongly indicates that gas hydrate can be found in reservoir quality sands. The LWD acquired data provided unprecedented information on the nature of the sediments and the occurrence of gas hydrate in the Gulf of Mexico.

  13. ET Cha - a single T Tauri star with a disk of radius ˜ 5 AU ?

    NASA Astrophysics Data System (ADS)

    Woitke, P.; Dent, W. R. F.; Thi, W.-F.; Menard, F.; Pinte, C.; Duchene, G.; Sandell, G.; Lawson, W.; Kamp, I.

    2013-07-01

    The 6-8 Myrs old M3-type TTauri star ET Cha (aka RECX 15) is a member of the eta Chamaeleontis moving group at a distance of about 94pc. Its protoplanetary disc was easily detected by Spitzer (IRAC, MIPS, IRS) in the near and mid-IR, and optical and near-IR line observations show clear evidence for active accretion (˜1.E-9 Msun/yr), outflows (also ˜1.E-9 Msun/yr), and H2 in the disc. However, previous attempts to detect this source in the sub-mm failed, including the search for CO J=3-2 with APEX, because ET Cha is apparently extraordinary faint at longer wavelengths. In a previous paper, Woitke et al.(2011) concluded that this disc must be exceptionally small (<10 AU) in order to explain all the available continuum and line data. We present new cycle-0 ALMA data that show a clear detection of ET Cha at 850um continuum, as well as a 7-sigma detection of the CO J=3-2 line. The CO emission is characterised by a double-peak emission profile with FHWM ˜15 km/s, which suggests an outer disc radius of only about 5 AU. We discuss these results by means of the Monte-Carlo radiative transfer program MCMax (main developer Michiel Min) and the radiation thermo-chemical gas code ProDiMo (main developers Peter Woitke, Wing-Fai Thi and Inga Kamp), which have been coupled in the frame of the European FP7-2011-SPACE project DIANA, under grant agreement no 284405.

  14. Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy.

    PubMed

    Siegismund, Christine S; Rohde, Maria; Kühl, Uwe; Escher, Felicitas; Schultheiss, Heinz Peter; Lassner, Dirk

    2016-08-01

    MicroRNAs (miRNAs) can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples (tissue, serum, peripheral blood mononuclear cells or other body fluids) differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. Since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissues and body fluids from patients with different diseases (cardiomyopathies, Alzheimer's disease, bladder cancer, and ocular cancer) were analyzed and compared in this study. miRNA expression data were generated by microarray or TaqMan PCR-based platforms. Lists of absent miRNAs of primarily cardiac patients (myocardium, blood cells, and serum) were clustered and analyzed for potentially involved pathways using two prediction platforms, i.e., miRNA enrichment analysis and annotation tool (miEAA) and DIANA miRPath. Extensive search in biomedical publication databases for the relevance of non-expressed miRNAs in predicted pathways revealed no evidence for their involvement in heart-related pathways as indicated by software tools, confirming proposed approach. PMID:27475403

  15. Effect of Surface Alloying by Silicon on the Corrosion Resistance and Biocompatibility of the Binary NiTi

    NASA Astrophysics Data System (ADS)

    Psakhie, S. G.; Meisner, S. N.; Lotkov, A. I.; Meisner, L. L.; Tverdokhlebova, A. V.

    2014-07-01

    This paper presents the study on changes in element and phase compositions in the near-surface layer and on surface topography of the NiTi specimens after the silicon ion-beam treatment. The effect of these parameters of the near-surface layer on corrosion properties in biochemical solutions and biocompatibility with mesenchymal stem cells of rat marrow is studied. Ion-beam surface modification of the specimens was performed by a DIANA-3 implanter (Tomsk, Russia), using single-ion-beam pulses under oil-free pumping and high vacuum (10-4 Pa) conditions in a high-dose ion implantation regime. The fluence made 2 × 1017 cm-2, at an average accelerating voltage of 60 kV, and pulse repetition frequency of 50 Hz. The silicon ion-beam treatment of specimen surfaces is shown to bring about a nearly twofold improvement in the corrosion resistance of the material to attack by aqueous solutions of NaCl (artificial body fluid) and human plasma and a drastic decrease in the nickel concentration after immersion of the specimens into the solutions for ~3400 and ~6000 h, respectively (for the artificial plasma solution, a nearly 20-fold decrease in the Ni concentration is observed). It is shown that improvement of NiTi corrosion resistance after treatment by Si ions occurs mainly due to the formation of two-layer composite coating based on Ti oxides (outer layer) on the NiTi surface and adjacent inner layer of oxides, carbides, and silicides of the NiTi alloy components. Inner layer with high silicon concentration serves as a barrier layer preventing nickel penetration into biomedium. This, in our opinion, is the main reason why the NiTi alloy exhibits no cytotoxic properties after ion modification of its surface and leads to the biocompatibility improvement at the cellular level, respectively.

  16. Modelling planet-forming circumstellar discs

    NASA Astrophysics Data System (ADS)

    Woitke, P.

    2012-03-01

    With the improved wavelength coverage and instrumental capabilities to observe planet-forming circumstellar discs in the X-ray regime, the UV, and the near, mid and far infrared (XMM, HST, VLT, Spitzer, Herschel, soon ALMA) there is an increasing scientific need to develop equally sophisticated models for the physical, radiative and chemical processes in these discs. The discs are composed of dust and gas spanning 10 orders of magnitude in density, and temperatures differ by a factor of about 100. There is hard irradiation that provokes various non-LTE effects, thermal and position de-coupling of icy dust and gas, and the differential rotation causes instabilities and mixing. In the last few years, new theoretical models have been developed that simulate different aspects of these complicated physical systems. I will focus mainly on models that model the chemical, radiative, and heating & cooling processes in these discs, pointing out some important coupling mechanism and feedbacks between them. In the new major European FP7-SPACE project DIANA, we will use these novel disc models to coherently analyse and interpret new multi-wavelength data sets from X-ray to cm, probing in physics and chemistry in protoplanetary dicsc at different radii and depths. The general aim of the new models is to arrive at a common understanding of dust and gas, over the full radial extent of the disc, and to make use of continuum and line observations to constrain dust and gas properties in the disc. I will discuss where the various near-IR to sub-mm emissions (CO ro-vib, high-J CO lines, sub-mm CO lines, Spitzer water, Herschel/PACS water, Herschel/HIFI water, Herschel/PACS atomic lines) originate from, and how they are influenced by disc shape, irradiation, dust properties, and the chemical and radiative details.

  17. Recent Progress in GW-based Methods for Excited-State Calculations of Reduced Dimensional Systems

    NASA Astrophysics Data System (ADS)

    da Jornada, Felipe H.

    2015-03-01

    Ab initio calculations of excited-state phenomena within the GW and GW-Bethe-Salpeter equation (GW-BSE) approaches allow one to accurately study the electronic and optical properties of various materials, including systems with reduced dimensionality. However, several challenges arise when dealing with complicated nanostructures where the electronic screening is strongly spatially and directionally dependent. In this talk, we discuss some recent developments to address these issues. First, we turn to the slow convergence of quasiparticle energies and exciton binding energies with respect to k-point sampling. This is very effectively dealt with using a new hybrid sampling scheme, which results in savings of several orders of magnitude in computation time. A new ab initio method is also developed to incorporate substrate screening into GW and GW-BSE calculations. These two methods have been applied to mono- and few-layer MoSe2, and yielded strong environmental dependent behaviors in good agreement with experiment. Other issues that arise in confined systems and materials with reduced dimensionality, such as the effect of the Tamm-Dancoff approximation to GW-BSE, and the calculation of non-radiative exciton lifetime, are also addressed. These developments have been efficiently implemented and successfully applied to real systems in an ab initio framework using the BerkeleyGW package. I would like to acknowledge collaborations with Diana Y. Qiu, Steven G. Louie, Meiyue Shao, Chao Yang, and the experimental groups of M. Crommie and F. Wang. This work was supported by Department of Energy under Contract No. DE-AC02-05CH11231 and by National Science Foundation under Grant No. DMR10-1006184.

  18. Further evidence for formation of a narrow baryon resonance with positive strangeness in K + collisions with Xe nuclei

    NASA Astrophysics Data System (ADS)

    Barmin, V. V.; Asratyan, A. E.; Borisov, V. S.; Curceanu, C.; Davidenko, G. V.; Dolgolenko, A. G.; Guaraldo, C.; Kubantsev, M. A.; Larin, I. F.; Matveev, V. A.; Shebanov, V. A.; Shishov, N. N.; Sokolov, L. I.; Tumanov, G. K.

    2007-01-01

    We have continued our investigation of the charge-exchange reaction K +Xe → K 0 pXe’ in the bubble chamber DIANA. In agreement with our previous results based on part of the present statistics, formation of a narrow pK 0 resonance with mass of 1537 ± 2 MeV/c 2 is observed in the elementary transition K + n → K 0 p on a neutron bound in the xenon nucleus. The visible width of the peak is consistent with being entirely due to instrumental resolution and allows one to place an upper limit on its intrinsic width: Γ < 9 MeV/c 2. A more precise estimate of the resonance intrinsic width, Γ = 0.36 ± 0.11 MeV/c 2, is obtained from the ratio between the numbers of resonant and nonresonant charge-exchange events. The signal is observed in a restricted interval of incident K + momentum that is consistent with smearing of a narrow pK 0 resonance by Fermi motion of the target neutron. The statistical significance of the signal is some 7.3, 5.3, and 4.3 standard deviations for the estimators S/sqrt B ,S/sqrt {S + B} and S/sqrt {S + 2B} , respectively. This observation confirms and reinforces our earlier results, and offers strong evidence for formation of a pentaquark baryon with positive strangeness in the charge-exchange reaction K + n → K 0 p on a bound neutron.

  19. The relationship between caves minerals and hypogene speleogenesis along the Cerna Valley (SW Romania)

    NASA Astrophysics Data System (ADS)

    Onac, B. P.; Sumrall, J.; Tamas, T.; Povara, I.; Veres, D.; Darmiceanu, V.; Lascu, C.

    2009-04-01

    Over 100 caves are known to develop in the Jurassic and Cretaceous limestone that outcrops on both sides of the Cerna Valley in southwestern Romania. High temperature anomalies are rather uncommon in the cave environment; however, in certain caves in the lower part of Cerna Valley one can measure air temperatures as high as 40°C. This situation is due to the presence of thermal water pooling or flowing through the caves or to the hot steam that rises along fractures from deeper thermal water pools. During the long evolution of the thermo-mineral activity along the Cerna Valley interaction has occurred on a wide scale between the cave host rock or/and cave sediments and the ascending hot steam or/and thermal solutions of all types (mainly sulfide-rich). The present work documents the products of these processes and record the occurrence of twenty-four secondary cave minerals (both of primarily or replacement origin) precipitated under particular cave environments. Among these, glauberite, apjonite, halotrichite, pickeringite, rapidcreekite, tamarugite, and darapskite are the most interesting. The mineral samples were investigated by means of X-ray diffraction, electron microprobe, Fourier-transformed infrared spectroscopy, and scanning electron microscope analyses with the scope of linking the cave minerals with possible hypogene speleogenetic processes. The isotopic measurements (δ34S) performed on sulfate speleothems contribute valuable information on both minerals and caves origin. Apart from two minerals (i.e., calcite and gypsum), which were identified in every cave investigated so far, all the others fall into three distinct associations that have resulted from specific reactions under highly particular settings in Diana (sulfate-dominated association), Adam (phosphate-dominated), and Great Sălitrari (sulfate/phosphate/nitrate-rich association) caves. These three remarkable cave occurrences are presented along with morphological features that confirm the

  20. PREFACE 16 ISCMP: Progress in Solid State and Molecular Electronics, Ionics and Photonics

    NASA Astrophysics Data System (ADS)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Petrov, Alexander G.; Primatarowa, Marina T.

    2010-11-01

    We are pleased to introduce the Proceedings of the 16 ISCMP, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. The School was dedicated to the late Professor Joe Marshall, who served for a long time as Chairman and Honorary Chairman and left us just after having completed the proceedings of the previous School. Like previous events, the School took place in the beautiful Black Sea resort of Saint Constantine and Elena near Varna, going back to the renewed facilities of the Panorama hotel. Participants from 19 different countries delivered 34 invited lecturers and 75 posters, contributing to three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the articles published in this volume illustrate the diversity and the high level of the contributions. Not the least significant factor in the success of the 16 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. These Proceedings are published for the first time in Journal of Physics: Conference Series. We are grateful to the Journal's staff for encouraging this idea. The Scientific Committee of the ISCMP dedicates this volume of the Proceedings to the living memory of Professor Joe Marshall, Honorary Chairman of the ISCMP. The Committee decided that the next event will take place again in Saint Constantine and Elena, in September 2012. It will be entitled: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications. Doriana Dimova-Malinovska, Diana Nesheva, Alexander G Petrov and Marina T Primatarowa

  1. Nonlinear Behavior of RC Dual Ductility Mode Shear Walls

    NASA Astrophysics Data System (ADS)

    Labafzadeh, M. S. R.; Ziyaeifar, M.

    2008-07-01

    Shear walls are among the most common lateral load resisting systems in medium height buildings. This is due, mostly, to their ability in providing the required level of lateral stiffness and strength for the structure (with simplicity and ease). However, shear walls are not considered as efficient structural component if ductility is the major concern. The fact is, in a tall shear wall, formation of plastic hinge happen only in a fraction of the height of the wall and ductility resources of the rest of the wall remains, mostly, untapped. The experiences with coupled shear walls have shown the potential of dispersion of inelastic behavior over the height of the wall, causing more desirable ductile behavior and a better crack pattern for the whole system. Intuitively, the same concept can be extended to the shear walls with openings. In such cases, both flexural and shear ductility capacity of the system over the height of the wall can be efficiently used to provide us with a dual ductility mode shear wall. This study focuses on the role of openings in ductile behavior of shear walls. The objective of this paper is comparing the nonlinear behavior of ordinary reinforced concrete shear wall with the ones with openings. To this end, the TNO DIANA finite element software is used to show the potential of dual ductility mode of behavior in shear walls with openings. In this regards a series of inelastic static analysis on a variety of shear walls have been carried out. The results of study in a wide variety of shear walls indicate that the potential of openings in the enhancement of ductility modes of such walls in comparison with those without openings.

  2. Predicting microRNA modulation in human prostate cancer using a simple String IDentifier (SID1.0).

    PubMed

    Albertini, Maria C; Olivieri, Fabiola; Lazzarini, Raffaella; Pilolli, Francesca; Galli, Francesco; Spada, Giorgio; Accorsi, Augusto; Rippo, Maria R; Procopio, Antonio D

    2011-08-01

    To make faster and efficient the identification of mRNA targets common to more than one miRNA, and to identify new miRNAs modulated in specific pathways, a computer program identified as SID1.0 (simple String IDentifier) was developed and successfully applied in the identification of deregulated miRNAs in prostate cancer cells. This computationally inexpensive Fortran program is based on the strategy of exhaustive search and specifically designed to screen shared data (target genes, miRNAs and pathways) available from PicTar and DIANA-MicroT 3.0 databases. As far as we know this is the first software designed to filter data retrieved from available miRNA databases. SID1.0 takes advantage of the standard Fortran intrinsic functions for manipulating text strings and requires ASCII input files. In order to demonstrate SID1.0 applicability, some miRNAs expected from the literature to associate with cancerogenesis (miR-125b, miR-148a and miR-141), were randomly identified as main entries for SID1.0 to explore matching sequences of mRNA targets and also to explore KEGG pathways for the presence of ID codes of targeted genes. Besides genes and pathways already described in the literature, SID1.0 has proven to useful for predicting other genes involved in prostate carcinoma. These latter were used to identify new deregulated miRNAs: miR-141, miR-148a, miR-19a and miR-19b. Prediction data were preliminary confirmed by expression analysis of the identified miRNAs in androgen-dependent (LNCaP) and independent (PC3) prostate carcinoma cell lines and in normal prostatic epithelial cells (PrEC). PMID:21334455

  3. How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study

    PubMed Central

    Carotenuto, Felicia; Albertini, Maria C.; Coletti, Dario; Vilmercati, Alessandra; Campanella, Luigi; Darzynkiewicz, Zbigniew; Teodori, Laura

    2016-01-01

    The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of DDR. Dietary bioactive compounds through miRs may affect activity of numerous genes. Among the most studied bioactive compounds modulating expression of miRs are epi-gallocatechin-3-gallate, curcumin, resveratrol and n3-polyunsaturated fatty acids. To compare the impact of these dietary compounds on DD/DDR network modulation, we performed a literature search and an in silico analysis by the DIANA-mirPathv3 software. The in silico analysis allowed us to identify pathways shared by different miRs involved in DD/DDR vis-à-vis the specific compounds. The results demonstrate that certain miRs (e.g., -146, -21) play a central role in the interplay among DD/DDR and the bioactive compounds. Furthermore, some specific pathways, such as “fatty acids biosynthesis/metabolism”, “extracellular matrix-receptor interaction” and “signaling regulating the pluripotency of stem cells”, appear to be targeted by most miRs affected by the studied compounds. Since DD/DDR and these pathways are strongly related to aging and carcinogenesis, the present in silico results of our study suggest that monitoring the induction of specific miRs may provide the means to assess the antiaging and chemopreventive properties of particular dietary compounds. PMID:27213347

  4. Correlates of objectively measured physical activity in adolescents with Down syndrome: the UP & DOWN study.

    PubMed

    Izquierdo-Gomez, Rocío; Veiga, Óscar L; Sanz, Alberto; Fernhall, Bo; Díaz-Cueto, Mario; Villagra, Ariel

    2015-06-01

    Introducción: los correlatos de actividad física (AF) no han sido estudiados en adolescentes con síndrome de Down (SD). Entendiendo los correlatos de AF se podría aportar información para desarrollar estrategias para incrementar los niveles de AF en esta población diana. Objetivo: el objetivo de este estudio fue identificar correlatos de AF en adolescentes con SD. Métodos: la información de los niveles de AF y sus potenciales correlatos fue recogida en 98 adolescentes con SD (63 hombres, con edades comprendidas entre 11-20 años), usando acelerómetros y cuestionarios proxy-reportados. Se utilizó análisis de covarianza y análisis de regresión lineal múltiple para examinar los correlatos de AF. Resultados: nuestros resultados muestran que la edad y el estatus socioeconómico de los participantes fue asociado con niveles de AF como correlatos no modificables. Además, el apoyo de los padres, la AF del padre y el tiempo dedicado a ver la televisión con hermanos y amigos fueron asociados con niveles de AF como correlatos modificables. Discusión y conclusión: ambos factores modificables y no modificables se asocian con niveles de AF en adolescentes con SD. Por lo tanto, una mejor comprensión de los correlatos de AF podría contribuir a desarrollar estrategias de promoción de la AF en adolescentes con SD.

  5. Silencing of the major family of NBS-LRR-encoding genes in lettuce results in the loss of multiple resistance specificities.

    PubMed

    Wroblewski, Tadeusz; Piskurewicz, Urszula; Tomczak, Anna; Ochoa, Oswaldo; Michelmore, Richard W

    2007-09-01

    The RGC2 gene cluster in lettuce (Lactuca sativa) is one of the largest known families of genes encoding nucleotide binding site-leucine-rich repeat (NBS-LRR) proteins. One of its members, RGC2B, encodes Dm3 which determines resistance to downy mildew caused by the oomycete Bremia lactucae carrying the cognate avirulence gene, Avr3. We developed an efficient strategy for analysis of this large family of low expressed genes using post-transcriptional gene silencing (PTGS). We transformed lettuce cv. Diana (carrying Dm3) using chimeric gene constructs designed to simultaneously silence RGC2B and the GUS reporter gene via the production of interfering hairpin RNA (ihpRNA). Transient assays of GUS expression in leaves accurately predicted silencing of both genes and were subsequently used to assay silencing in transgenic T(1) plants and their offspring. Levels of mRNA were reduced not only for RGC2B but also for all seven diverse RGC2 family members tested. We then used the same strategy to show that the resistance specificity encoded by the genetically defined Dm18 locus in lettuce cv. Mariska is the result of two resistance specificities, only one of which was silenced by ihpRNA derived from RGC2B. Analysis of progeny from crosses between transgenic, silenced tester stocks and lettuce accessions carrying other resistance genes previously mapped to the RGC2 locus indicated that two additional resistance specificities to B. lactucae, Dm14 and Dm16, as well as resistance to lettuce root aphid (Pemphigus bursarius L.), Ra, are encoded by RGC2 family members. PMID:17587302

  6. Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression

    PubMed Central

    Singh, Ashok; Willems, Estelle; Singh, Anupama; Hafeez, Bilal Bin; Ong, Irene M.; Mehta, Suresh L.; Verma, Ajit Kumar

    2016-01-01

    Chronic exposure to ultraviolet radiation (UVR) is linked to the development of cutaneous squamous cell carcinoma (SCC), a non-melanoma form of skin cancer that can metastasize. Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, is linked to UVR-induced development of SCC. To find clues about the mechanisms by which TNFα may promote UVR-induced development of SCC, we investigated changes in the expression profiling of microRNAs (miRNA), a novel class of short noncoding RNAs, which affects translation and stability of mRNAs. In this experiment, TNFα knockout (TNFα KO) mice and their wild type (WT) littermates were exposed to acute UVR (2.0 kJ/m2) and the expression profiling of epidermal miRNA was determined 4hr post UVR exposure. TNFα deletion in untreated WT mice resulted in differential expression (log fold change>1) of seventeen miRNA. UVR exposure in WT mice induced differential expression of 22 miRNA. However, UVR exposure in TNFα KO mice altered only two miRNAs. Four miRNA, were differentially expressed between WT+UVR and TNFα KO+UVR groups. Differentially expressed selected miRNAs were further validated using real time PCR. Few of the differentially expressed miRNAs (miR-31-5p, miR-196a-5p, miR-127-3p, miR-206-3p, miR-411-5p, miR-709, and miR-322-5p) were also observed in UVR-induced SCC. Finally, bio-informatics analysis using DIANA, MIRANDA, Target Scan, and miRDB algorithms revealed a link with major UVR-induced pathways (MAPK, PI3K-Akt, transcriptional mis-regulation, Wnt, and TGF-beta). PMID:26918454

  7. Dehydration triggers differential microRNA expression in Xenopus laevis brain.

    PubMed

    Luu, Bryan E; Storey, Kenneth B

    2015-11-15

    African clawed frogs, Xenopus laevis, although primarily aquatic, have a high tolerance for dehydration, being capable of withstanding the loss of up to 32-35% of total water body water. Recent studies have shown that microRNAs play a role in the response to dehydration by the liver, kidney and ventral skin of X. laevis. MicroRNAs act by modulating the expression of mRNA transcripts, thereby affecting diverse biochemical pathways. In this study, 43 microRNAs were assessed in frog brains comparing control and dehydrated (31.2±0.83% of total body water lost) conditions. MicroRNAs of interest were measured using a modified protocol which employs polyadenylation of microRNAs prior to reverse transcription and qPCR. Twelve microRNAs that showed a significant decrease in expression (to 41-77% of control levels) in brains from dehydrated frogs (xla-miR-15a, -150, -181a, -191, -211, -218, -219b, -30c, -30e, -31, -34a, and -34b) were identified. Genomic analysis showed that the sequences of these dehydration-responsive microRNAs were highly conserved as compared with the comparable microRNAs of mice (91-100%). Suppression of these microRNAs implies that translation of the mRNA transcripts under their control could be enhanced in response to dehydration. Bioinformatic analysis using the DIANA miRPath program (v.2.0) predicted the top two KEGG pathways that these microRNAs collectively regulate: 1. Axon guidance, and 2. Long-term potentiation. Previous studies indicated that suppression of these microRNAs promotes neuroprotective pathways by increasing the expression of brain-derived neurotrophic factor and activating anti-apoptotic pathways. This suggests that similar actions may be triggered in X. laevis brains as a protective response to dehydration. PMID:26169019

  8. Ranking of microRNA target prediction scores by Pareto front analysis.

    PubMed

    Sahoo, Sudhakar; Albrecht, Andreas A

    2010-12-01

    Over the past ten years, a variety of microRNA target prediction methods has been developed, and many of the methods are constantly improved and adapted to recent insights into miRNA-mRNA interactions. In a typical scenario, different methods return different rankings of putative targets, even if the ranking is reduced to selected mRNAs that are related to a specific disease or cell type. For the experimental validation it is then difficult to decide in which order to process the predicted miRNA-mRNA bindings, since each validation is a laborious task and therefore only a limited number of mRNAs can be analysed. We propose a new ranking scheme that combines ranked predictions from several methods and - unlike standard thresholding methods - utilises the concept of Pareto fronts as defined in multi-objective optimisation. In the present study, we attempt a proof of concept by applying the new ranking scheme to hsa-miR-21, hsa-miR-125b, and hsa-miR-373 and prediction scores supplied by PITA and RNAhybrid. The scores are interpreted as a two-objective optimisation problem, and the elements of the Pareto front are ranked by the STarMir score with a subsequent re-calculation of the Pareto front after removal of the top-ranked mRNA from the basic set of prediction scores. The method is evaluated on validated targets of the three miRNA, and the ranking is compared to scores from DIANA-microT and TargetScan. We observed that the new ranking method performs well and consistent, and the first validated targets are elements of Pareto fronts at a relatively early stage of the recurrent procedure, which encourages further research towards a higher-dimensional analysis of Pareto fronts.

  9. An atlas of type I MADS box gene expression during female gametophyte and seed development in Arabidopsis.

    PubMed

    Bemer, Marian; Heijmans, Klaas; Airoldi, Chiara; Davies, Brendan; Angenent, Gerco C

    2010-09-01

    Members of the plant type I MADS domain subfamily have been reported to be involved in reproductive development in Arabidopsis (Arabidopsis thaliana). However, from the 61 type I genes in the Arabidopsis genome, only PHERES1, AGAMOUS-LIKE80 (AGL80), DIANA, AGL62, and AGL23 have been functionally characterized, which revealed important roles for these genes during female gametophyte and early seed development. The functions of the other genes are still unknown, despite the fact that the available single T-DNA insertion mutants have been largely investigated. The lack of mutant phenotypes is likely due to a considerable number of recent intrachromosomal duplications in the type I subfamily, resulting in nonfunctional genes in addition to a high level of redundancy. To enable a breakthrough in type I MADS box gene characterization, a framework needs to be established that allows the prediction of the functionality and redundancy of the type I genes. Here, we present a complete atlas of their expression patterns during female gametophyte and seed development in Arabidopsis, deduced from reporter lines containing translational fusions of the genes to green fluorescent protein and beta-glucuronidase. All the expressed genes were revealed to be active in the female gametophyte or developing seed, indicating that the entire type I subfamily is involved in reproductive development in Arabidopsis. Interestingly, expression was predominantly observed in the central cell, antipodal cells, and chalazal endosperm. The combination of our expression results with phylogenetic and protein interaction data allows a better identification of putative redundantly acting genes and provides a useful tool for the functional characterization of the type I MADS box genes in Arabidopsis. PMID:20631316

  10. The solution structure of motilin from NMR distance constraints, distance geometry, molecular dynamics, and an iterative full relaxation matrix refinement.

    PubMed

    Edmondson, S; Khan, N; Shriver, J; Zdunek, J; Gräslund, A

    1991-11-26

    A model of the structure of the 22 amino acid residue gastrointestinal peptide hormone motilin in 30% hexafluoro-2-propanol has been obtained by using distance constraints obtained from two-dimensional nuclear Overhauser enhancements. A set of initial structures have been generated by using the distance geometry program DIANA, and 10 of these structures have been refined by using restrained molecular dynamics (AMBER). The resulting structures are virtually indistinguishable in terms of constraint violations and energies and display less than 0.5-A root mean square deviations (RMSD) of the backbone atom positions from Tyr7 to Lys20. A comparison of back-calculated and experimental NOE intensities indicates that RMSD's are not the best indicators of the goodness of fit or of the precision with which the structure is defined. The structure was further refined by fitting the experimental NOE data using an iterative full relaxation matrix analysis. The mean error between the observed and calculated backbone NOE intensities for the final refined structure was 0.23 for the full length of the molecule, 0.18 for the region from Glu9 to Lys20, and 0.29 for the region from Phe1 to Gly8. R factors for the same regions were 0.27, 0.19, and 0.43, respectively. All of the NOE-determined structures consistently display an alpha-helix which extends from Glu9 to Lys20. Considerable lack of definition of structure exists at the amino and carboxyl ends of the molecule and also in the vicinity of Thr6-Tyr7-Gly8. A tendency to form a wide turn appears to exist over the sequence Pro3-Ile4-Phe5-Thr6, but the structure in this region is not well defined by the NOE data.

  11. Faunal assemblages of the mussel Mytilus galloprovincialis in and around Alsancak Harbour (Izmir Bay, eastern Mediterranean) with special emphasis on alien species

    NASA Astrophysics Data System (ADS)

    Çinar, Melih Ertan; Katağan, Tuncer; Koçak, Ferah; Öztürk, Bilal; Ergen, Zeki; Kocatas, Ahmet; Önen, Mesut; Kirkim, Fevzi; Bakir, Kerem; Kurt, Güley; Dağli, Ertan; Açik, Sermin; Doğan, Alper; Özcan, Tahir

    gallensis, Paradella dianae, Anadara demiri and Celleporaria brunnea. These species comprised 31% of the total number of individuals found during this study. H. elegans was the most dominant species among aliens, reaching a maximum density of 110,700 ind m - 2 (spring, at station 3, 63% of the total population) in the area. The total abundance of aliens was positively correlated with that of natives, but the total biomass value of aliens was negatively correlated with that of natives.

  12. Effect of fire-induced damage on the uniaxial strength characteristics of solid timber: A numerical study

    NASA Astrophysics Data System (ADS)

    Hopkin, D. J.; El-Rimawi, J.; Lennon, T.; Silberschmidt, V. V.

    2011-07-01

    The advent of the structural Eurocodes has allowed civil engineers to be more creative in the design of structures exposed to fire. Rather than rely upon regulatory guidance and prescriptive methods engineers are now able to use such codes to design buildings on the basis of credible design fires rather than accepted unrealistic standard-fire time-temperature curves. Through this process safer and more efficient structural designs are achievable. The key development in enabling performance-based fire design is the emergence of validated numerical models capable of predicting the mechanical response of a whole building or sub-assemblies at elevated temperature. In such a way, efficiency savings have been achieved in the design of steel, concrete and composite structures. However, at present, due to a combination of limited fundamental research and restrictions in the UK National Annex to the timber Eurocode, the design of fire-exposed timber structures using numerical modelling techniques is not generally undertaken. The 'fire design' of timber structures is covered in Eurocode 5 part 1.2 (EN 1995-1-2). In this code there is an advanced calculation annex (Annex B) intended to facilitate the implementation of numerical models in the design of fire-exposed timber structures. The properties contained in the code can, at present, only be applied to standard-fire exposure conditions. This is due to existing limitations related to the available thermal properties which are only valid for standard fire exposure. In an attempt to overcome this barrier the authors have proposed a 'modified conductivity model' (MCM) for determining the temperature of timber structural elements during the heating phase of non-standard fires. This is briefly outlined in this paper. In addition, in a further study, the MCM has been implemented in a coupled thermo-mechanical analysis of uniaxially loaded timber elements exposed to non-standard fires. The finite element package DIANA was adopted

  13. Nutritive quality of romanian hemp varieties (Cannabis sativa L.) with special focus on oil and metal contents of seeds

    PubMed Central

    2012-01-01

    Background The study aims to determine the nutritional value of hemp seed expressed by the oil content and by the concentration of metals (Ca, Mg, K, Fe, Mn, Zn and Cd), for five varieties of monoecious and dioecious hemp seeds approved in Romania, comparative with the concentration of these metals in the soil. Results The content of oil in hempseed registers a slight decrease in the production records of 2011, losses due to drought and low levels of precipitation during the growth period. The greatest loss is found in Diana monoecious variety (26.54-20.82%) followed by Zenit varieties (27.37-22.97%), Armanca (29.27-25.32%), Silvana (28.89-25.04%) and Denise (26.96-25.30%). Siccative hemp oil has a yellowish green color and an iodine index of 140–156 g I2/100 g oil. Hemp seed are rich in mineral based Ca (144–955 mg/100 g seed), Mg (237–694 mg/100 g seed), K (463–2821 mg/100 g seed), Fe (1133-2400 mg.kg-1), Mn (63–110 mg.kg-1) and Zn (42-94 mg.kg-1). For the soil the following macroelements concentrations were determined: Ca (2100–2520 mg.kg-1), Mg (320–376 mg.kg-1) and K (232–257 mg.kg-1). Mn (156–197 mg.kg-1) and Zn (54–67 mg.kg-1) remain within normal limits for Romania. The soils in the experience area contain large amounts of Fe (19000–20430 mg.kg-1). The presence of K in large quantities determines the accumulation of large quantities of Fe in the soil. Conclusion Hempseed belonging to the five Romanian varieties are rich source of nutrients (Ca, Mg, K) and unsaturated oil easily digestible by the body, but the presence of Cd concentrations above the upper limit puts a question mark over the use of seeds in various food products. Hemp extracts easily certain metals from the soil. Significant amounts of Fe (1133–2400 mg.kg-1), Mn (63–110 mg.kg-1), Zn (42–94 mg.kg-1) and Cd (1.3-4.0 mg.kg-1) are found in hemp seeds. Hemp (Cannabis sativa L.) is included among plants suitable for phytoremediation of soil contaminated with cadmium

  14. PROKARYOTIC EXPRESSION AND BIOACTIVITY EVALUATION OF THE CHIMERIC GENE DERIVED FROM THE GROUP 1 ALLERGENS OF DUST MITES.

    PubMed

    Zhan, Xiaodong; Li, Chaopin; Guo, Wei; Jiang, Yuxin

    2015-12-01

    Antecedentes: se reconstituyó con éxito el gen del grupo 1 alérgenos de los ácaros del polvo, y obtuvo un conjunto de genes barajadas. Con el fin de verificar la predicción en el gen quimérico, hemos clonado tentativamente R8 en el vector que se expresó prokaryoticly, purificó y se evaluó por sus actividades-bio. Métodos: el producto expresado se detectó por SDS-PAGE y la proteína diana se purificó. La proteína purificada R8 se detectó por ELISA. Setenta y cinco ratones BALB/ c se dividieron en 5 grupos, a saber: PBS, rDer f1, rDer p1, R8 y el grupo de asma. Los ratones fueron tratados con alérgenos de ácaros del polvo a los 0, 7, 14 días mediante inyección intraperitoneal y inhaladas desafío como aerosol en día 21 durante 7 días. La inmunoterapia específica para el alérgeno se realizó utilizando rDer f1, rDer p1 y alérgenos R8, respectivamente. El nivel de IFN e IL-4 en BALF se detectó por ELISA. Resultados: el gen quimérico R8 se expresó con una banda de aproximadamente Mr 35000. En comparación con los grupos de rDer f 1 y rDer p 1 [(80,44 ± 15,50) y (90,79 ± 10,38) μg/ml, respectivamente], la capacidad de unión a IgE de la proteína R8 (37,03 ± 12,46) μg/ml fue estadísticamente inferior (P.

  15. Developing a Carbon Observing System

    NASA Astrophysics Data System (ADS)

    Moore, B., III

    2015-12-01

    There is a clear need to better understand and predict future climate change, so that science can more confidently inform climate policy, including adaptation planning and future mitigation strategies. Understanding carbon cycle feedbacks, and the relationship between emissions (fossil and land use) and the resulting atmospheric carbon dioxide (CO2) and methane (CH4) concentrations in a changing climate has been recognized as an important goal by the IPCC. The existing surface greenhouse gas observing networks provide accurate and precise measurements of background values, but they are not configured to target the extended, complex and dynamic regions of the carbon budget. Space Agencies around the globe are committed to CO2 and CH4 observations: GOSAT-1/2, OCO-2/3, MERLin, TanSat, and CarbonSat. In addition to these Low Earth Orbit (LEO) missions, a new mission in Geostationary Orbit (GEO), geoCARB, which would provide mapping-like measurements of carbon dioxide, methane, and carbon monoxide concentrations over major land areas, has been recently proposed to the NASA Venture Program. These pioneering missions do not provide the spatial/temporal coverage to answer the key carbon-climate questions at process relevant scales nor do they address the distribution and quantification of anthropogenic sources at urban scales. They do demonstrate, however, that a well-planned future system of system integrating space-based LEO and GEO missions with extensive in situ observations could provide the accuracy, spatial resolution, and coverage needed to address critical open issues in the carbon-climate system. Dr. Diana Wickland devoted enormous energy in developing a comprehensive apprioach to understand the global carbon cycle; she understood well that an integrated, coordinated, international approach is needed. This shines through in her recent contribution in co-chairing the team that produced the "CEOS Strategy for Carbon Observations from Space." A NASA-funded community

  16. Obituary: Preston F. Gott, 1919-2002

    NASA Astrophysics Data System (ADS)

    Myles, Charles Wesley

    2003-12-01

    Scholarship Award in Physics and also endowed a scholarship in the Women's Studies Program, in memory of his first wife, long time TTU Economics Professor Edna Gott. He was a true gentleman and a friend to all who knew him. He will be sorely missed. He is survived by his wife, Orene, and his children, Eugene and Suzanne. His stepchildren are Ruth, Benita, and Diana (who pre-deceased him).

  17. Camões e a cosmogonia

    NASA Astrophysics Data System (ADS)

    Costa, J. M.

    2003-08-01

    Os Lusíadas, escrito por Luis de Camões em 1572, é um poema épico renascentista e a visão Cosmogônica do autor é apresentada, principalmente, no último canto do poema, quando Tétis mostra ao Gama a Máquina do Mundo. A Cosmogonia de Camões neste poema reflete uma visão de uma época de transição, que ainda não incorporou os elementos da revolução Copernicana. É uma visão Grego- Ptolomaica e também medieval. O poeta guia-se pela tradução e notas feita por Pedro Nunes, inventor do Nonio, do Tratado da Esfera "De Sphaera" do Astrônomo Inglês John Holywood, mais conhecido pelo nome latinizado de Johannes Sacrobosco. Outra provável fonte de Camões, de acordo com Luciano Antonio Pereira da Silva em Astronomia de os Lusíadas, é o "Theoricae novae Planetarum" (1460) do astrólogo Alemão Jorge Purbáquio (1423 - 1461). A Astronomia de Os Lusíadas representa a ciência do tempo de Camões. Camões nunca emprega a palavra constelação e seu catálogo é bastante completo. A Máquina do Mundo tem a Terra no centro. Em redor, em círculos concêntricos, a lua (Diana), Mercúrio, Vênus, o Sol (Febo), Marte, Júpiter e Saturno. Envolvendo estes astros tem o firmamento seguido pelo "Céu Áqueo" ou cristalino, depois o 1o Móbil, esfera que arrasta todas as outras consigo. Este trabalho, multidisciplinar, serve tanto para ensinar aos alunos da Física como das Ciências Humanas, a concepção de mundo do renascimento de uma forma belamente poética em versos decassílabos Este trabalho também ajuda na apreciação do maior clássico da língua portuguesa e mostra como as Ciências e as artes, em geral, estão correlacionadas e refletem a visão de mundo da época em que foi produzida.

  18. PREFACE: FAIRNESS 2014: FAIR Next Generation ScientistS 2014

    NASA Astrophysics Data System (ADS)

    2015-04-01

    is dedicated to the physics at FAIR. February 2015, Organizers of FAIRNESS 2014: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Conference photograph

  19. Ion beam extraction from electron cyclotron resonance ion sources and the subsequent low energy beam transport

    NASA Astrophysics Data System (ADS)

    Winklehner, Daniel

    simulation results. These tests suggest that the model is suited for the simulation of ion beam extraction and transport for medium to high charge states of medium to heavy ions, but not for the lowest charge states and lightest ions (He1+, protons). Finally, as an example application of the developed software, a variable-energy (300 kV - 3 MV) electrostatic accelerator was simulated and redesigned for the DIANA project, a new proposed underground laboratory for nuclear astrophysics.

  20. PREFACE: FAIRNESS 2012: FAIR NExt Generation of ScientistS 2012

    NASA Astrophysics Data System (ADS)

    Arcones, Almudena; Bleicher, Marcus; Fritsch, Miriam; Galatyuk, Tetyana; Nicmorus, Diana; Petersen, Hannah; Ratti, Claudia; Tolos, Laura

    2013-03-01

    forefront of research that is dedicated to the physics of FAIR. February 2013, Organizers of FAIRNESS 2012: Almudena Arcones, Marcus Bleicher, Miriam Fritsch, Tetyana Galatyuk, Diana Nicmorus, Hannah Petersen, Claudia Ratti and Laura Tolos Support for holding the conference was provided by: logos

  1. PREFACE: FAIRNESS 2013: FAIR NExt generation of ScientistS 2013

    NASA Astrophysics Data System (ADS)

    Petersen, Hannah; Destefanis, Marco; Galatyuk, Tetyana; Montes, Fernando; Nicmorus, Diana; Ratti, Claudia; Tolos, Laura; Vogel, Sascha

    2014-04-01

    research that is dedicated to the physics of FAIR. February 2014. Organizers of FAIRNESS 2013: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Logos

  2. High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

    PubMed Central

    Kong, Yan; Liang, Xijun; Liu, Lin; Zhang, Dongdong; Wan, Chao; Gan, Zhenji; Yuan, Liudi

    2015-01-01

    Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of Lewy bodies. As the main component of Lewy bodies, α-synuclein is implicated in PD pathogenesis by aggregation into insoluble filaments. However, the detailed mechanisms underlying α-synuclein induced neurotoxicity in PD are still elusive. MicroRNAs are ~20nt small RNA molecules that fine-tune gene expression at posttranscriptional level. A plethora of miRNAs have been found to be dysregulated in the brain and blood cells of PD patients. Nevertheless, the detailed mechanisms and their in vivo functions in PD still need further investigation. By using Drosophila PD model expressing α-synuclein A30P, we examined brain miRNA expression with high-throughput small RNA sequencing technology. We found that five miRNAs (dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p, dme-miR-932-5p, dme-miR-1008-5p) were upregulated in PD flies. Among them, miR-13b, miR-133, miR-137 are brain enriched and highly conserved from Drosophila to humans. KEGG pathway analysis using DIANA miR-Path demonstrated that neuroactive-ligand receptor interaction pathway was most likely affected by these miRNAs. Interestingly, miR-137 was predicted to regulate most of the identified targets in this pathway, including dopamine receptor (DopR, D2R), γ-aminobutyric acid (GABA) receptor (GABA-B-R1, GABA-B-R3) and N-methyl-D-aspartate (NMDA) receptor (Nmdar2). The validation experiments showed that the expression of miR-137 and its targets was negatively correlated in PD flies. Further experiments using luciferase reporter assay confirmed that miR-137 could act on specific sites in 3’ UTR region of D2R, Nmdar2 and GABA-B-R3, which downregulated significantly in PD flies. Collectively, our findings indicate that α-synuclein could induce the dysregulation of miRNAs, which target neuroactive ligand

  3. Economic evaluation in collaborative hospital drug evaluation reports.

    PubMed

    Ortega, Ana; Fraga, María Dolores; Marín-Gil, Roberto; Lopez-Briz, Eduardo; Puigventós, Francesc; Dranitsaris, George

    2015-09-01

    Objetivo: la evaluación económica es un criterio fundamental en el posicionamiento de medicamentos. El método MADRE (Método de Ayuda para la toma de Decisiones y la Realización de Evaluaciones de medicamentos) es ampliamente utilizado en la evaluación de medicamentos. Fue desarrollado por el grupo GENESIS de la Sociedad Española de Farmacia Hospitalaria (SEFH), e incluye una evaluación económica. Con objeto de mejorar los aspectos económicos de este método, analizaremos la experiencia previa con esta metodología y propondremos mejoras. Método: revisión retrospectiva de las evaluaciones económicas en los informes de evaluación de medicamentos realizados de forma colaborativa (como SEFH) con el método MADRE. Resultados: se revisaron 32 informes, el 87,5% incluían una evaluación económica realizada por los autores y un 65,6% una publicada. El 90,6% incluían un análisis de impacto presupuestario. 14 informes incluían el coste por año de vida o por año de vida ganado ajustado por calidad. 23 informes recibieron alegaciones relacionadas con la evaluación económica. Las principales dificultades fueron: baja calidad de la evidencia en la población diana, falta de estudios comparativos con el comparador relevante, resultados finales no evaluados, falta de datos de calidad de vida, precio del medicamento no fijado, incertidumbre en la dosis y diferentes precios del medicamento. Conclusiones: mejoras propuestas: incorporar ayudas para inclusión de costes no farmacológicos, estimación de la supervivencia y adaptación de evaluaciones económicas publicadas; establecer criterios para: selección de precios, toma de decisiones en condiciones de incertidumbre o evidencia pobre, cálculo de dosis y umbrales de coste-efectividad en diferentes situaciones.

  4. [A short-term training program reduced acute phase proteins in premenopausal women with metabolic syndrome].

    PubMed

    Rosety-Rodríguez, Manuel; Fornieles, Gabriel; Camacho-Molina, Alejandra; Rosety, Ignacio; Díaz, Antonio J; Rosety, Miguel A; Rodríguez-Pareja, Antonia; Ordonez, Francisco J

    2013-01-01

    Fundamento y objetivo: Actualmente se acepta la importancia del estatus proinflamatorio en la fisiopatología del síndrome metabólico. De hecho, ha sido propuesto como diana terapéutica en el manejo clínico de estos pacientes. Por consiguiente este estudio pretende reducir los niveles plasmáticos de reactantes de fase aguda en mujeres con síndrome metabólico mediante un corto programa de entrenamiento. Material y método: Un total de 135 mujeres jóvenes adultas (38,4 ± 3,3 años) con diagnóstico de síndrome metabólico participaron voluntariamente en este estudio. El grupo de intervención se sometió a un programa de entrenamiento aeróbico de 12 semanas, con 3 sesiones/ semana en el que duración e intensidad de la parte principal se incrementaron progresivamente. Los niveles plasmáticos de proteína C-reactiva (PCR) y fibrinógeno se determinaron mediante nefelometría y HPLC respectivamente. También se evaluaron el fitness cardiovascular mediante prueba de esfuerzo máxima e índices de distribución de masa grasa. Este protocolo fue aprobado por un Comité de Ética Institucional. Resultados: Tras completar el programa, se observo una mejora significativa del fitness cardiovascular además de una reducción también significativa de los niveles de fibrinógeno y PCR. Asimismo, se encontraron correlaciones entre niveles de reactantes e índices de distribución de masa grasa, siendo la de mayor fuerza de asociación la establecida entre PCR y perímetro cintura. Conclusión: Un programa de 12 semanas consiguió reducir los niveles de reactantes de fase aguda en mujeres con síndrome metabólico. Futuros estudios longitudinales son necesarios para conocer el impacto del efecto anti-inflamatorio del ejercicio en el manejo de estos pacientes a medio/largo plazo.

  5. OrbId

    PubMed Central

    Filshtein, Teresa J.; Mackenzie, Craig O.; Dale, Maurice D.; Dela-Cruz, Paul S.; Ernst, Dale M.; Frankenberger, Edward A.; He, Chunyan; Heath, Kaylee L.; Jones, Andria S.; Jones, Daniel K.; King, Edward R.; Maher, Maggie B.; Mitchell, Travis J.; Morgan, Rachel R.; Sirobhushanam, Sirisha; Halkyard, Scott D.; Tiwari, Kiran B.; Rubin, David A.; Borchert, Glen M.; Larson, Erik D.

    2012-01-01

    MicroRNAs coordinate networks of mRNAs, but predicting specific sites of interactions is complicated by the very few bases of complementarity needed for regulation. Although efforts to characterize the specific requirements for microRNA (miR) regulation have made some advances, no general model of target recognition has been widely accepted. In this work, we describe an entirely novel approach to miR target identification. The genomic events responsible for the creation of individual miR loci have now been described with many miRs now known to have been initially formed from transposable element (TE) sequences. In light of this, we propose that limiting miR target searches to transcripts containing a miR’s progenitor TE can facilitate accurate target identification. In this report we outline the methodology behind OrbId (Origin-based identification of microRNA targets). In stark contrast to the principal miR target algorithms (which rely heavily on target site conservation across species and are therefore most effective at predicting targets for older miRs), we find OrbId is particularly efficacious at predicting the mRNA targets of miRs formed more recently in evolutionary time. After defining the TE origins of > 200 human miRs, OrbId successfully generated likely target sets for 191 predominately primate-specific human miR loci. While only a handful of the loci examined were well enough conserved to have been previously evaluated by existing algorithms, we find ~80% of the targets for the oldest miR (miR-28) in our analysis contained within the principal Diana and TargetScan prediction sets. More importantly, four of the 15 OrbId miR-28 putative targets have been previously verified experimentally. In light of OrbId proving best-suited for predicting targets for more recently formed miRs, we suggest OrbId makes a logical complement to existing, conservation based, miR target algorithms. PMID:23087843

  6. Seafloor distribution and last glacial to postglacial activity of mud volcanoes on the Calabrian accretionary prism, Ionian Sea

    NASA Astrophysics Data System (ADS)

    Ceramicola, Silvia; Praeg, Daniel; Cova, Andrea; Accettella, Daniela; Zecchin, Massimo

    2014-06-01

    Mud volcanoes (MVs) are abundant along the eastern Mediterranean subduction zones, recording mud breccia extrusion over long timescales (106 years), but to date relatively few have been recognised in the northern Ionian Sea on the Calabrian accretionary prism (CAP). In the present study, the seafloor distribution and recent activity of MVs is investigated across a 35,600 km2 sector of the CAP using a regional acoustic dataset (multibeam bathymetric and backscatter imagery, integrated with subbottom profiles) locally ground-truthed by sediment cores. A total of 54 MVs are identified across water depths of 150-2,750 m using up to four geophysical criteria: distinctive morphology, high backscatter, unstratified subbottom facies and, in one case, a hydroacoustic flare. Fourteen MVs are identified from 3-4 criteria, of which five have been previously proven by cores containing mud breccia beneath up to 1.6 m of hemipelagic sediments (Madonna dello Ionio MVs 1-3, Pythagoras MV and the newly named Sartori MV), while nine others are identified for the first time (Athena, Catanzaro, Cerere, Diana, Giunone, Minerva, `right foot', Venere 1 and 2). Forty other as yet unnamed MVs are inferred from 1-2 geophysical criteria (three from distinctive morphology alone). All but one possible MV lie on the inner plateau of the CAP, landwards of the Calabrian Escarpment in a zone up to 120 km wide that includes the inner pre-Messinian wedge and the fore-arc basins, where they are interpreted to record the ascent from depth of overpressured fluids that interacted with tectonic structures and with evaporitic or shale seals within the fore-arc basins. The rise of fluids may have been triggered by post-Messinian out-of-sequence tectonism that affected the entire pre-Messinian prism, but Plio-Quaternary sedimentation rates and depositional styles support the inference that significant mud volcanism has taken place only on the inner plateau. Sedimentation rates across the CAP applied to a 12

  7. MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas.

    PubMed

    Butz, Henriett; Likó, István; Czirják, Sándor; Igaz, Péter; Korbonits, Márta; Rácz, Károly; Patócs, Attila

    2011-06-01

    MicroRNAs (miRs) are small, 16-29 nucleotide long, non-coding RNA molecules which regulate the stability or translational efficiency of targeted mRNAs via RNA interference. MiRs participate in the control of cell proliferation, cell differentiation, signal transduction, cell death, and they play a role in carcinogenesis. The aims of our study were to analyse the expression profile of miRs in sporadic clinically non-functioning pituitary adenomas (NFPA) and in normal pituitary tissues, and to identify biological pathways altered in these pituitary tumors. MiR expression profiles of 12 pituitary tissue specimens (8 NFPA and 4 normal pituitary tissues) were determined using miR array based on quantitative real-time PCR with 678 different primers. Five overexpressed miRs and mRNA expression of Smads (Smad1-9), MEG and DLK1 genes were evaluated with individual Taqman assays in 10 NFPA and 10 normal pituitary tissues. Pathway analysis was performed by the DIANA-mirPath tool. Complex bioinformatical analysis by multiple algorithms and association studies between miRs, Smad3 and tumor size was performed. Of the 457 miRs expressed in both NFPA and normal tissues, 162 were significantly under- or overexpressed in NFPA compared to normal pituitary tissues Expression of Smad3, Smad6, Smad9, MEG and DLK1 was significantly lower in NFPA than in normal tissues. Pathway analysis together with in silico target prediction analysis indicated possible downregulation of the TGFβ signaling pathway in NFPA by a specific subset of miRs. Five miRs predicted to target Smad3 (miR-135a, miR-140-5p, miR-582-3p, miR-582-5p and miR-938) were overexpressed. Correlation was observed between the expression of seven overexpressed miRs and tumor size. Downregulation of the TGFβ signaling through Smad3 via miRs may have a possible role in the complex regulation of signaling pathways involved in the tumorigenesis process of NFPA. PMID:21063788

  8. New perspectives on litigation and the public's health.

    PubMed

    Bontá, Diana; Praeger, Sandra; Schlichtmann, Jan

    2002-01-01

    This article provides redacted versions of three presentations by distinguished individuals with long experience in litigation or regulation to protect the public's health. A central theme is the need to develop partnerships to promote protection efforts. Jan Schlichtmann is internationally recognized for his representation of eight Massachusetts families engaged in legal action against two major companies, W. R. Grace and Beatrice Foods, in a fight to obtain justice in a groundbreaking case that has been the subject of many press and journal reports along with a nationally best-selling book and motion picture titled A Civil Action. His inspiring story of a long and difficult struggle to uncover the truth about contaminants in drinking water caused by buried wastes and to bring public health authorities and others together in a partnership to address the problem is a model of the use of litigation tools to protect the public's health. Diana Bontá, Director of the California Department of Health Services, discusses the efforts of her department to ensure the integrity of the Medi-Cal program that her department administers and the proper uses of litigation, including decisions to avoid litigation, for the purpose of protecting the public's health. She focuses on regulatory and legal efforts to protect her state's citizens and their environment, with an emphasis on the use of common sense in making decisions about whether to litigate and on partnering with advisory groups and members of the public as a means of aiding her department's accomplishment of its mission. Finally, Sandy Praeger, a state senator from Kansas, discusses efforts to use the law and regulation for the purpose of protecting the Kansas River. She stresses the importance of using sound judgment, backed by assessment of the legislative and physical environments, to make the right decisions regarding the use of the law for public health protection. She also points out that sometimes one can use the

  9. [Analisis of the budget impact of adalimumab and etanercept in rheumatoid arthritis and spondyloarthropathies].

    PubMed

    González Álvarez, A; Gómez Barrera, M; Borrás Blasco, J; Giner Serret, E J

    2013-01-01

    Objetivo: Evaluar el impacto económico derivado de la ampliación de los intervalos de administración de adalimumab (ADA) y etanercept (ETN), en el tratamiento de la artritis reumatoide (AR) y espondiloartropatias (EAP) en nuestro ámbito de trabajo. Material y método: Se desarrolló un modelo de impacto presupuestario (MIP) para estimar la repercusión económica que tendría la ampliación en los intervalos habituales de administración de ADA 40 mg cada dos semanas y ETN 50 mg semanal (escenario A), por ADA 40 mg cada tres semanas y ETN 50 mg cada dos semanas (escenario B) de acuerdo a las guías y recomendaciones que se aplican a estos estudios, especificando la población diana, la perspectiva del estudio, el horizonte temporal y analizando la robustez del estudio a través de un análisis de sensibilidad univariante de tipo umbral. Resultados: Se incluyeron un total de 71 pacientes en el estudio. La aplicación del MIP mostró unos ahorros anuales para ADA y ETN de 19.784??y 38.271 ??respectivamente. El coste neto, es decir, el ahorro que esto supuso en el horizonte temporal considerado (dos años) ascendió a 116.110 ?. El análisis de sensibilidad realizado mostró que el MIP estimado para el periodo de estudio fue muy robusto ya que el resultado neto en diferentes escenarios apenas variaba, manteniéndose negativo en los nuevos escenarios. Conclusiones: La ampliación de los intervalos de administración de ADA y ETN cada tres semanas y dos semanas respectivamente, sería una estrategia que permitiría generar ahorros en el presupuesto hospitalario cercanos a los 116.110 ??en el horizonte temporal considerado, consiguiendo así una optimización del tratamiento con estos fármacos.

  10. Geologic Mapping of Isabella Quadrangle (V-50) and Helen Planitia, Venus

    NASA Technical Reports Server (NTRS)

    Bleamaster, Leslie F., III

    2008-01-01

    (25-50 S, 180-210 E) is host to numerous coronae and small volcanic centers (paterae and shield fields), focused (Aditi and Sirona Dorsa) and distributed (penetrative north-south trending wrinkle ridges) contractional deformation, and radial and linear extensional structures, all of which contribute materials to and/or deform the expansive surrounding plains (Nsomeka and Wawalag Planitiae). Regional plains, which are a northern extension of regional plains mapped in the Barrymore Quadrangle V-59 [1], dominate the V-50 quadrangle. Previous mapping divided the regional plains into two members: regional plains, members a and b [2]. A re-evaluation of these members has determined that a continuous and consistent unit contact does not exist; however, the majority of this radar unit or surficial unit will still be displayed on the final map as a stipple pattern as it is a prevalent feature of the quadrangle. With minimal tessera or highland material, much of the quadrangle s oldest materials are plains units (the regional plains). Much of these plains are covered with small shield edifices that exhibit a variety of material contributions (or flows). In the northwest, several flows emerge and flow to the southeast from Diana-Dali Chasmata. Local corona- and mons-fed flows superpose the regional plains; however, earlier stages of volcano-tectonic centers marked by arcuate and radial structural elements, including terrain so heavily deformed that it takes on a new appearance, may have developed prior to or concurrently with the region plains. Northtrending deformation belts disrupt the central portion of the map area and wrinkle ridges parallel these larger belts. Isabella crater, in the northeastern quadrant, is highly asymmetric and displays two prominent ejecta blanket morphologies, which generally correlate with distance from the impact structure suggesting that ejecta block size or ejecta blanket thickness may be the cause. The crater floor is very dark and shows no

  11. The Response of microRNAs to Solar UVR in Skin-Resident Melanocytes Differs between Melanoma Patients and Healthy Persons

    PubMed Central

    Sha, Jingfeng; Gastman, Brian R.; Morris, Nathan; Mesinkovska, Natasha A.; Baron, Elma D.; Cooper, Kevin D.; McCormick, Thomas; Arbesman, Joshua; Harter, Marian L.

    2016-01-01

    The conversion of melanocytes into cutaneous melanoma is largely dictated by the effects of solar ultraviolet radiation (UVR). Yet to be described, however, is exactly how these cells are affected by intense solar UVR while residing in their natural microenvironment, and whether their response differs in persons with a history of melanoma when compared to that of healthy individuals. By using laser capture microdissection (LCM) to isolate a pure population of melanocytes from a small area of skin that had been intermittingly exposed or un-exposed to physiological doses of solar UVR, we can now report for the first time that the majority of UV-responsive microRNAs (miRNAs) in the melanocytes of a group of women with a history of melanoma are down-regulated when compared to those in the melanocytes of healthy controls. Among the miRNAs that were commonly and significantly down-regulated in each of these women were miR-193b (P<0.003), miR-342-3p (P<0.003), miR186 (P<0.007), miR-130a (P<0.007), and miR-146a (P<0.007). To identify genes potentially released from inhibition by these repressed UV-miRNAs, we analyzed databases (e.g., DIANA-TarBase) containing experimentally validated microRNA-gene interactions. In the end, this enabled us to construct UV-miRNA-gene regulatory networks consisting of individual genes with a probable gain-of-function being intersected not by one, but by several down-regulated UV-miRNAs. Most striking, however, was that these networks typified well-known regulatory modules involved in controlling the epithelial-to-mesenchymal transition and processes associated with the regulation of immune-evasion. We speculate that these pathways become activated by UVR resulting in miRNA down regulation only in melanocytes susceptible to melanoma, and that these changes could be partially responsible for empowering these cells toward tumor progression. PMID:27149382

  12. The Brera Multi-scale Wavelet ROSAT HRI source catalogue

    NASA Astrophysics Data System (ADS)

    Panzera, M. R.; Campana, S.; Covino, S.; Lazzati, D.; Mignani, R. P.; Moretti, A.; Tagliaferri, G.

    2003-02-01

    We present the Brera Multi-scale Wavelet ROSAT HRI source catalogue (BMW-HRI) derived from all ROSAT HRI pointed observations with exposure times longer than 100 s available in the ROSAT public archives. The data were analyzed automatically using a wavelet detection algorithm suited to the detection and characterization of both point-like and extended sources. This algorithm is able to detect and disentangle sources in very crowded fields and/or in the presence of extended or bright sources. Images have been also visually inspected after the analysis to ensure verification. The final catalogue, derived from 4303 observations, consists of 29 089 sources detected with a detection probability of >=4.2 sigma . For each source, the primary catalogue entries provide name, position, count rate, flux and extension along with the relative errors. In addition, results of cross-correlations with existing catalogues at different wavelengths (FIRST, IRAS, 2MASS and GSC2) are also reported. Some information is available on the web via the DIANA Interface. As an external check, we compared our catalogue with the previously available ROSHRICAT catalogue (both in its short and long versions) and we were able to recover, for the short version, ~ 90% of the entries. We computed the sky coverage of the entire HRI data set by means of simulations. The complete BMW-HRI catalogue provides a sky coverage of 732 deg2 down to a limiting flux of ~ 10-12 erg s-1 cm-2 and of 10 deg2 down to ~ 10-14 erg s-1 cm-2. We were able to compute the cosmological log(N)-log(S) distribution down to a flux of =~ 1.2 x 10-14 erg s-1 cm-2. The catalogue is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/399/351

  13. Solution structure of the phosphocarrier protein HPr from Bacillus subtilis by two-dimensional NMR spectroscopy.

    PubMed Central

    Wittekind, M.; Rajagopal, P.; Branchini, B. R.; Reizer, J.; Saier, M. H.; Klevit, R. E.

    1992-01-01

    The solution structure of the phosphocarrier protein, HPr, from Bacillus subtilis has been determined by analysis of two-dimensional (2D) NMR spectra acquired for the unphosphorylated form of the protein. Inverse-detected 2D (1H-15N) heteronuclear multiple quantum correlation nuclear Overhauser effect (HMQC NOESY) and homonuclear Hartmann-Hahn (HOHAHA) spectra utilizing 15N assignments (reported here) as well as previously published 1H assignments were used to identify cross-peaks that are not resolved in 2D homonuclear 1H spectra. Distance constraints derived from NOESY cross-peaks, hydrogen-bonding patterns derived from 1H-2H exchange experiments, and dihedral angle constraints derived from analysis of coupling constants were used for structure calculations using the variable target function algorithm, DIANA. The calculated models were refined by dynamical simulated annealing using the program X-PLOR. The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88. The structure is comprised of a four-stranded antiparallel beta-sheet with two antiparallel alpha-helices on one side of the sheet. The active-site His 15 residue serves as the N-cap of alpha-helix A, with its N delta 1 atom pointed toward the solvent to accept the phosphoryl group during the phosphotransfer reaction with enzyme I. The existence of a hydrogen bond between the side-chain oxygen atom of Tyr 37 and the amide proton of Ala 56 is suggested, which may account for the observed stabilization of the region that includes the beta-turn comprised of residues 37-40. If the beta alpha beta beta alpha beta (alpha) folding topology of HPr is considered with the peptide chain polarity reversed, the protein fold is identical to that described for another group of beta alpha beta beta alpha beta proteins that include acylphosphatase and the RNA-binding domains of the U1 snRNP A and hnRNP C proteins. PMID:1303754

  14. Interplay between microRNA-17-5p, insulin-like growth factor-II through binding protein-3 in hepatocellular carcinoma

    PubMed Central

    Habashy, Danira Ashraf; El Tayebi, Hend Mohamed; Fawzy, Injie Omar; Hosny, Karim Adel; Esmat, Gamal; Abdelaziz, Ahmed Ihab

    2016-01-01

    AIM To investigate the effect of microRNA on insulin-like growth factor binding protein-3 (IGFBP-3) and hence on insulin-like growth factor-II (IGF-II) bioavailability in hepatocellular carcinoma (HCC). METHODS Bioinformatic analysis was performed using microrna.org, DIANA lab and Segal lab softwares. Total RNA was extracted from 23 HCC and 10 healthy liver tissues using mirVana miRNA Isolation Kit. microRNA-17-5p (miR-17-5p) expression was mimicked and antagonized in HuH-7 cell lines using HiPerFect Transfection Reagent, then total RNA was extracted using Biozol reagent then reverse transcribed into cDNA followed by quantification of miR-17-5p and IGFBP-3 expression using TaqMan real-time quantitative PCR. Luciferase reporter assay was performed to validate the binding of miR-17-5p to the 3’UTR of IGFBP-3. Free IGF-II protein was measured in transfected HuH-7 cells using IGF-II ELISA kit. RESULTS Bioinformatic analysis revealed IGFBP-3 as a potential target for miR-17-5p. Screening of miR-17-5p and IGFBP-3 revealed a moderate negative correlation in HCC patients, where miR-17-5p was extensively underexpressed in HCC tissues (P = 0.0012), while IGFBP-3 showed significant upregulation in the same set of patients (P = 0.0041) compared to healthy donors. Forcing miR-17-5p expression in HuH-7 cell lines showed a significant downregulation of IGFBP-3 mRNA expression (P = 0.0267) and a significant increase in free IGF-II protein (P = 0.0339) compared to mock untransfected cells using unpaired t-test. Luciferase assay validated IGFBP-3 as a direct target of miR-17-5p; luciferase activity was inhibited by 27.5% in cells co-transfected with miR-17-5p mimics and the construct harboring the wild-type binding region 2 of IGFBP-3 compared to cells transfected with this construct alone (P = 0.0474). CONCLUSION These data suggest that regulating IGF-II bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of mi

  15. Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

    SciTech Connect

    McMahon, James E.; Wiel, Stephen

    2001-02-16

    Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the programs

  16. [Probiotics: from the lab to the consumer].

    PubMed

    Rodríguez, J M

    2015-02-07

    Introducción: En los últimos años, el campo de los probióticos ha experimentado un gran auge. Sin embargo, de los miles de cepas aisladas cada año por su potencial probiótico en los laboratorios de todo el mundo, muy pocas pasan a una fase de desarrollo industrial y menos aún son las que consiguen una vida comercial. Objetivo: En este artículo, se revisan los principales aspectos que se deben tener en cuenta en el, habitualmente, largo y tortuoso camino que debe seguir una cepa desde su aislamiento inicial hasta su comercialización. Resultados y conclusiones: Cualquier microorganismo probiótico debe estar correctamente identificado a nivel de especie y cepa. La secuencia del genoma es la mejor identificación posible, además de proporcionar información muy valiosa sobre su seguridad, funcionalidad y propiedades de interés tecnológico. Los casos en los que se ha podido establecer una relación entre un probiótico y un efecto adverso son muy escasos y han afectado a personas con patologías subyacentes. Globalmente, aunque las distintas pruebas in vitro, ex vivo y en modelos animales proporcionan información útil durante el proceso de selección de cepas, los únicos datos que permiten evaluar la seguridad y eficacia de un probiótico de una forma directa son los que se obtienen en el curso de ensayos clínicos correctamente diseñados y dirigidos específicamente a la población diana. Por otra parte, las empresas que comercializan probióticos tienen la necesidad de obtener una biomasa muy elevada de forma económicamente rentable y de que la concentración de bacterias viables necesaria para ejercer el efecto beneficioso se mantenga hasta el final de la vida útil del producto. Finalmente, los aspectos comerciales son determinantes en la decisión de afrontar el desarrollo industrial y la puesta en el mercado de un probiótico.

  17. Interplay between microRNA-17-5p, insulin-like growth factor-II through binding protein-3 in hepatocellular carcinoma

    PubMed Central

    Habashy, Danira Ashraf; El Tayebi, Hend Mohamed; Fawzy, Injie Omar; Hosny, Karim Adel; Esmat, Gamal; Abdelaziz, Ahmed Ihab

    2016-01-01

    AIM To investigate the effect of microRNA on insulin-like growth factor binding protein-3 (IGFBP-3) and hence on insulin-like growth factor-II (IGF-II) bioavailability in hepatocellular carcinoma (HCC). METHODS Bioinformatic analysis was performed using microrna.org, DIANA lab and Segal lab softwares. Total RNA was extracted from 23 HCC and 10 healthy liver tissues using mirVana miRNA Isolation Kit. microRNA-17-5p (miR-17-5p) expression was mimicked and antagonized in HuH-7 cell lines using HiPerFect Transfection Reagent, then total RNA was extracted using Biozol reagent then reverse transcribed into cDNA followed by quantification of miR-17-5p and IGFBP-3 expression using TaqMan real-time quantitative PCR. Luciferase reporter assay was performed to validate the binding of miR-17-5p to the 3’UTR of IGFBP-3. Free IGF-II protein was measured in transfected HuH-7 cells using IGF-II ELISA kit. RESULTS Bioinformatic analysis revealed IGFBP-3 as a potential target for miR-17-5p. Screening of miR-17-5p and IGFBP-3 revealed a moderate negative correlation in HCC patients, where miR-17-5p was extensively underexpressed in HCC tissues (P = 0.0012), while IGFBP-3 showed significant upregulation in the same set of patients (P = 0.0041) compared to healthy donors. Forcing miR-17-5p expression in HuH-7 cell lines showed a significant downregulation of IGFBP-3 mRNA expression (P = 0.0267) and a significant increase in free IGF-II protein (P = 0.0339) compared to mock untransfected cells using unpaired t-test. Luciferase assay validated IGFBP-3 as a direct target of miR-17-5p; luciferase activity was inhibited by 27.5% in cells co-transfected with miR-17-5p mimics and the construct harboring the wild-type binding region 2 of IGFBP-3 compared to cells transfected with this construct alone (P = 0.0474). CONCLUSION These data suggest that regulating IGF-II bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of miRNAs.

  18. Every Student Counts: Broadening Participation in the Geosciences through a Multiyear Internship Program

    NASA Astrophysics Data System (ADS)

    Sloan, V.

    2010-12-01

    , every student counts. Diana Prado Garzon at work in summer of 2010.

  19. MicroRNA profile in very young women with breast cancer

    PubMed Central

    2014-01-01

    Background Breast cancer is rarely diagnosed in very young women (35years old or younger), and it often presents with distinct clinical-pathological features related to a more aggressive phenotype and worse prognosis when diagnosed at this early age. A pending question is whether breast cancer in very young women arises from the deregulation of different underlying mechanisms, something that will make this disease an entity differentiated from breast cancer diagnosed in older patients. Methods We performed a comprehensive study of miRNA expression using miRNA Affymetrix2.0 array on paraffin-embedded tumour tissue of 42 breast cancer patients 35 years old or younger, 17 patients between 45 and 65 years old and 29 older than 65 years. Data were statistically analyzed by t-test and a hierarchical clustering via average linkage method was conducted. Results were validated by qRT-PCR. Putative targeted pathways were obtained using DIANA miRPath online software. Results The results show a differential and unique miRNA expression profile of 121 miRNAs (p-value <0.05), 96 of those with a FDR-value <0.05. Hierarchical clustering grouped the samples according to their age, but not by subtype nor by tumour characteristics. We were able to validate by qRT-PCR differences in the expression of 6 miRNAs: miR-1228*, miR-3196, miR-1275, miR-92b, miR-139 and miR-1207. Moreover, all of the miRNAs maintained the expression trend. The validated miRNAs pointed out pathways related to cell motility, invasion and proliferation. Conclusions The study suggests that breast cancer in very young women appears as a distinct molecular signature. To our knowledge, this is the first time that a validated microRNA profile, distinctive to breast cancer in very young women, has been presented. The miRNA signature may be relevant to open an important field of research in order to elucidate the underlying mechanism in this particular disease, which in a more clinical setting, could potentially help to

  20. Structure of human salivary histatin 5 in aqueous and nonaqueous solutions.

    PubMed

    Raj, P A; Marcus, E; Sukumaran, D K

    1998-01-01

    The solution structure of human salivary histatin 5 (D-S-H-A-K-R-H-H-G-Y-K-R-K-F-H-E-K-H-H-S-H-R-G-Y) was examined in water (pH 3.8) and dimethyl sulfoxide solutions using 500 MHz homo- and heteronuclear two-dimensional (2D) nmr. The resonance assignment of peptide backbone and side-chain protons was accomplished by 2D total correlated spectroscopy and nuclear Overhauser effect (NOE) spectroscopy. The high JNH-C alpha H values (> or = 7.4 Hz), absence of any characteristic NH-NH (i, i + 1) or C alpha H-C beta H (i, i + 3) NOE connectivities, high d delta/dT values (> or = 0.004 ppm K-1) and the fast 1H/2H amide exchange suggest that histatin 5 molecules remain unstructured in aqueous solution at pH 3.8. In contrast, histatin 5 prefers largely alpha-helical conformation in dimethyl sulfoxide solution as evident from the JNH-C alpha H values (< or = 6.4 Hz), slow 1H/2H exchange, low d delta/dT values (< or = 0.003 ppm K-1) observed for amide resonances of residues 6-24, and the characteristic NH-NH (i, i + 1) and C alpha H-C beta H (i, i + 3) NOE connectivities. All backbone amide 15N-1H connectivities fall within 6 ppm on the 15N scale in the 2D heteronuclear single quantum correlated spectrum, and the restrained structure calculations using DIANA suggest the prevalence of alpha-helical conformations stabilized by 19 (5-->1) intramolecular backbone amide hydrogen bonds in polar aprotic medium such as dimethyl sulfoxide. The interside-chain hydrogen bonding and salt-bridge type interactions that normally stabilize the helical structure of linear peptides in aqueous solutions are not observed. Histatin 5, unlike other naturally occurring antimicrobial polypeptides such as magainins, defensins, and tachyplesins, does not adopt amphiphilic structure, precluding its insertion into microbial membranes and formation of ion channels across membranes. Electrostatic (ionic type) and hydrogen bonding interactions of the positively charged and polar residues with the head

  1. Near-Infrared Hyperspectral Image Cubes of Mars during the 1999 Opposition

    NASA Technical Reports Server (NTRS)

    Hillman, John J.; Glenar, D.; Espenak, F.; Chanover, N.; Murphy, J.; Young, L.; Blass, W.

    1999-01-01

    and Fred Espenak from GSFC, Nancy Chanover, Jim Murphy and A. S. MurTell from NMSU, Leslie Young from BU, Diana Blaney from JPL and Dick Joyce from KPNO.

  2. Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication

    PubMed Central

    He, Shuming; Zeng, Shumei; Zhou, Zhi-Wei; He, Zhi-Xu; Zhou, Shu-Feng

    2015-01-01

    The aberrant expression of human microRNA-181a-1 (hsa-miR-181a) has been implicated in the pathogenesis of various cancers, serving as an oncogene or a tumor suppressor. However, the role of hsa-miR-181a in the pathogenesis of endometrial carcinoma (EC) and its clinical significance are unclear. This study aimed to search for the molecular targets of hsa-miR-181a using bioinformatic tools and then determine the expression levels of hsa-miR-181a in normal, hyperplasia, and EC samples from humans. To predict the targets of hsa-miR-181a, ten different algorithms were used, including miRanda-mirSVR, DIANA microT v5.0, miRDB, RNA22 v2, TargetMiner, TargetScan 6.2, PicTar, MicroCosm Targets v5, and miRWALK. Two algorithms, TarBase 6.0 and miRTarBase, were used to identify the validated targets of hsa-miR-181a-5p (a mature product of hsa-miR-181a), and the web-based Database for Annotation, Visualization and Integrated Discovery (DAVID) 6.7 was used to provide biological functional interpretation of the validated targets of hsa-miR-181a-5p. A total of 78 formalin-fixed, paraffin-embedded tissue specimens from 65 patients and 13 healthy subjects were collected and examined, including normal endometrium (n=13), endometrial hyperplasia (n=18), and EC (37 type I and 10 type II EC cases). Our bioinformatic studies have showed that hsa-miR-181a might regulate a large number of target genes that are important in the regulation of critical cell processes, such as cell fate, cell survival, metabolism, and cell death. To date, 313 targets of hsa-miR-181a have been validated, and 22 of these targets are cancer genes. The precision of predictions by all the algorithms for hsa-miR-181a-1’s targets was low. Many of these genes are involved in tumorigenesis of various cancers, including EC, based on the DAVID and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. In comparison with normal endometrial tissue, the expression level of hsa-miR-181a was significantly

  3. PREFACE: 14th Latin American Workshop on Plasma Physics (LAWPP 2011)

    NASA Astrophysics Data System (ADS)

    Bilbao, Luis; Minotti, Fernando; Kelly, Hector

    2012-06-01

    , Venezuela Leopoldo Soto, Chile Michael Tendler, Sweden Carlos Varandas, Portugal Henry Riascos, Colombia Ivan Vargas-Blanco, Costa Rica Local Organizing Committee Luis Bilbao (Chairman) Fernando Minotti (Vice-Chairman) Luis Bernal, UNMDP Alejandro Clausse, PLADEMA-CNEA Graciela Gnavi, INFIP, CONICET-UBA Fausto Gratton, INFIP, CONICET-UBA Diana Grondona, INFIP, CONICET-UBA Héctor Kelly, INFIP, CONICET-UBA Adriana Márquez, INFIP, CONICET-UBA María Milanese, UNCPBA César Moreno, INFIP, CONICET-UBA Sponsors Instituto de Física del Plasma (INFIP) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Comisión Nacional de Energía Atómica (CNEA) Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) Centro Latino-Americano de Física (CLAF) Universidad Nacional de Mar del Plata (UNMP) Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) Academia Nacional de Ciencias de Buenos Aires (ANCBA) Conference poster

  4. Human impact and Holocene climatic change in the archaeological site 'Piani della Corona

    NASA Astrophysics Data System (ADS)

    Pelle, Teresa; Scarciglia, Fabio; La Russa, Mauro F.; Natali, Elena; Tinè, Vincenzo

    2010-05-01

    A pedoarchaeological study was carried out in the archaeological site "Piani della Corona", located on a wide terrace at 500 m a.s.l. along the southwestern coast of Calabria, in southern Italy. The archaeological excavations exhumed an extensive settlement related to old to medium Bronze Age phases and traces of late Neolithic human colonization. On the basis of archaeological finds the pedostratigraphic succession can be partly dated. It consists of soils with variable features and andic properties, which include yellowish-brown (in places more reddish), deep argillic (Bt) horizons with variable amounts of clay coatings in pores and dark brown infillings of soil material rich in organic matter, in places overlaid by thin, severely truncated, brown to dark brown, organic-mineral (A) horizons. These layers include late Neolithic ceramic artefacts (Diana style facies) and typical incineration burials found in biconical vases, that can be referred to 6500-5000 years BP. The prehistoric layers are widely overlaid and strongly superimposed by a paleosurface of the early to medium Bronze age. This surface is affected by many pole holes left by large rectangular, apsidal wooden huts (not preserved), ploughed furrows, excavated cisterns, ditches and trenches, often filled by organic-rich dark brown material. Also hearths with charcoal remains, burials, vases and other diagnostic ceramic fragments occur. The upper portion of the pedostratigraphic succession consists of thicker brown A horizons, that appear cyclically ploughed during historical times (archaeologically not well dated as a consequence of their reworking for agricultural practices), with abrupt irregular boundaries often entering the underlying horizons. Micromorphological observations confirmed the presence of clay coatings within pores of Bt horizons, showing that they represent relict features (i.e. related to inactive illuvial processes, at present), as often fragmented and with smooth-banded to grainy

  5. Effects of disodium fumarate on ruminal fermentation and microbial communities in sheep fed on high-forage diets.

    PubMed

    Zhou, Y W; McSweeney, C S; Wang, J K; Liu, J X

    2012-05-01

    microbiota after adding DF. Ten of 15 clone sequences from cut-out bands appearing in both the 2nd and the 4th week were 94% to 100% similar to Prevotella-like bacteria, and four sequences showed 95% to 98% similarity to Selenomonas dianae. Another 15 sequences were obtained from bands, which appeared in the 4th week only. Thirteen of these 15 sequences showed 95% to 99% similarity to Clostridium sp., and the other two showed 95% and 100% similarity to Ruminococcus sp. In summary, the microorganisms positively responding to DF addition were the cellulolytic bacteria, R. albus, F. succinogenes and B. fibrisolvens as well as proteolytic bacteria, B. fibrisolvens, P. ruminicola and Clostridium sp.

  6. Geologic map of the Rusalka Planitia Quadrangle (V-25), Venus

    USGS Publications Warehouse

    Young, Duncan A.; Hansen, Vicki L.

    2003-01-01

    The Rusalka Planitia quadrangle (herein referred to as V-25) occupies an 8.1 million square kilometer swath of lowlands nestled within the eastern highlands of Aphrodite Terra on Venus. The region (25?-0? N., 150?-180? E.) is framed by the crustal plateau Thetis Regio to the southwest, the coronae of the Diana-Dali chasmata complex to the south, and volcanic rise Atla Regio to the west. Regions to the north, and the quadrangle itself, are part of the vast lowlands, which cover four-fifths of the surface of Venus. The often-unspectacular lowlands of Venus are typically lumped together as ridged or regional plains. However, detailed mapping reveals the mode of resurfacing in V-25's lowlands: a mix of corona-related flow fields and local edifice clusters within planitia superimposed on a background of less clearly interpretable extended flow fields, large volcanoes, probable corona fragments, and edifice-flow complexes. The history detailed within the Rusalka Planitia quadrangle is that of the extended evolution of long-wavelength topographic basins in the presence of episodes of extensive corona-related volcanism, pervasive low-intensity small-scale eruptions, and an early phase of regional circumferential shortening centered on central Aphrodite Terra. Structural reactivation both obscures and illuminates the tectonic development of the region. The data are consistent with progressive lithospheric thickening, although the critical lack of an independent temporal marker on Venus severely hampers our ability to test this claim and correlate between localities. Two broad circular basins dominate V-25 geology: northern Rusalka Planitia lies in the southern half of the quadrangle, whereas the smaller Llorona Planitia sits along the northwestern corner of V-25. Similar large topographic basins occur throughout the lowlands of Venus, and gravity data suggest that some basins may represent dynamic topography over mantle downwellings. Both planitiae include coronae and

  7. PREFACE: The IARU International Scientific Congress on Climate Change: Global Risks, Challenges and Decisions (10-12 March, Copenhagen, Denmark)

    NASA Astrophysics Data System (ADS)

    2009-01-01

    by the IARU universities In keeping with normal scientific practice, a procedure for producing the synthesis report that has been adopted optimises the chances of arriving at a product that will receive a broad backing from the scientific community as being a message that can be sent to the non-scientific community and that explains current understanding in climate change science The Writing Team will also be responsible for writing the book Members of the Writing Team (in alphabetical order) Professor Joe Alcamo, University of Stellenbosch Dr Terry Barker, Cambridge University Professor Daniel Kammen, University of California - Berkeley Professor Rik Leemans, Environmental Systems Analysis Group, Wageningen University Professor Diana Liverman, Oxford University Professor Mohan Munasinghe, Chairman, Munasinghe Institute for Development (MIND) Dr Balgis Osman-Elasha, Higher Council for Environment and Natural Resources (HCENR), Sudan Professor Katherine Richardson, University of Copenhagen Professor John Schellnhuber, Potsdam Institute for Climate Impact Research and visiting professor at the University of Oxford Professor Will Steffen, Australian National University Professor Lord Nicholas Stern, London School of Economics and Political Science (LSE) Professor Ole Wæver, University of Copenhagen 2 Key Messages from the Congress Key Message 1: Climatic Trends Recent observations confirm that, given high rates of observed emissions, the worst-case IPCC scenario trajectories (or even worse) are being realized For many key parameters, the climate system is already moving beyond the patterns of natural variability within which our society and economy have developed and thrived These parameters include global mean surface temperature, sea-level rise, ocean and ice sheet dynamics, ocean acidification, and extreme climatic events There is a significant risk that many of the trends will accelerate, leading to an increasing risk of abrupt or irreversible climatic shifts Key

  8. True 3D kinematic analysis for slope instability assessment in the Siq of Petra (Jordan), from high resolution TLS

    NASA Astrophysics Data System (ADS)

    Gigli, Giovanni; Margottini, Claudio; Spizzichino, Daniele; Ruther, Heinz; Casagli, Nicola

    2016-04-01

    released, stratigraphic setting and tectonic activity can be recognized. As a consequence, rock-falls have been occurring, even recently, with unstable rock mass volumes ranging from 0.1 m3 up to over some hundreds m3. Slope instability, acceleration of crack deformation and consequent increasing of rock-fall hazard conditions, could threaten the safety of tourist as well as the integrity of the heritage. 3D surface model coming from Terrestrial Laser Scanner acquisitions was developed almost all over the site of Petra, including the Siq. Comprehensively, a point cloud of five billion points was generated making the site of Petra likely the largest scanned archaeological site in the word. As far as the Siq, the scanner was positioned on the path floor at intervals of not more than 10 meters from each station. The total number of scans in the Siq was 220 with an average point cloud interval of approximately 3 cm. Subsequently, for the definition of the main rockfall source areas, a spatial kinematic analysis for the whole Siq has been performed, by using discontinuity orientation data extracted from the point cloud by means of the software Diana. Orientation, number of sets, spacing/frequency, persistence, block size and scale dependent roughness was obtained combining fieldwork and automatic analysis. This kind of analysis is able to establish where a particular instability mechanism is kinematically feasible, given the geometry of the slope, the orientation of discontinuities and shear strength of the rock. The final outcome of this project was a detail landslide kinematic index map, reporting main potential instability mechanisms for a given area. The kinematic index was finally calibrated for each instability mechanism (plane failure; wedge failure; block toppling; flexural toppling) surveyed in the site. The latter is including the collapse occurred in May 2015, likely not producing any victim, in a sector clearly identified by the susceptibility maps produced by the

  9. A Historical Evaluation of the U12n Tunnel, Nevada National Security Site, Nye County, Nevada Part 1

    SciTech Connect

    Drollinger, Harold; Jones, Robert C; Bullard, Thomas F; Ashbaugh, Laurence J; Griffin, Wayne R

    2011-06-01

    This report presents a historical evaluation of the U12n Tunnel on the Nevada National Security Site (NNSS) in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency (DTRA). The U12n Tunnel was one of a series of tunnels used for underground nuclear weapons effects tests in Rainier and Aqueduct Mesas. A total of 22 nuclear tests were conducted in the U12n Tunnel from 1967 to 1992. These tests include Midi Mist, Hudson Seal, Diana Mist, Misty North, Husky Ace, Ming Blade, Hybla Fair, Mighty Epic, Diablo Hawk, Miners Iron, Huron Landing, Diamond Ace, Mini Jade, Tomme/Midnight Zephyr, Misty Rain, Mill Yard, Diamond Beech, Middle Note, Misty Echo, Mineral Quarry, Randsburg, and Hunters Trophy. DTRA sponsored all tests except Tomme and Randsburg which were sponsored by the Lawrence Livermore National Laboratory. Midnight Zephyr, sponsored by DTRA, was an add on experiment to the Tomme test. Eleven high explosive tests were also conducted in the tunnel and included a Stemming Plan Test, the Pre-Mill Yard test, the two seismic Non-Proliferation Experiment tests, and seven Dipole Hail tests. The U12n Tunnel complex is composed of the portal and mesa areas, encompassing a total area of approximately 600 acres (240 hectares). Major modifications to the landscape have resulted from four principal activities. These are road construction and maintenance, mining activities related to development of the tunnel complex, site preparation for activities related to testing, and construction of retention ponds. A total of 202 cultural features were recorded for the portal and mesa areas. At the portal area, features relate to the mining, construction, testing, and general everyday operational support activities within the tunnel. These include concrete foundations for buildings, ventilation

  10. A Historical Evaluation of the U12n Tunnel, Nevada national Security Site, Nye County, Nevada Part 2 of 2

    SciTech Connect

    Drollinger, Harold; Jones, Robert C; Bullard, Thomas F; Ashbaugh, Laurence J; Griffin, Wayne R

    2011-06-01

    This report presents a historical evaluation of the U12n Tunnel on the Nevada National Security Site (NNSS) in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency (DTRA). The U12n Tunnel was one of a series of tunnels used for underground nuclear weapons effects tests in Rainier and Aqueduct Mesas. A total of 22 nuclear tests were conducted in the U12n Tunnel from 1967 to 1992. These tests include Midi Mist, Hudson Seal, Diana Mist, Misty North, Husky Ace, Ming Blade, Hybla Fair, Mighty Epic, Diablo Hawk, Miners Iron, Huron Landing, Diamond Ace, Mini Jade, Tomme/Midnight Zephyr, Misty Rain, Mill Yard, Diamond Beech, Middle Note, Misty Echo, Mineral Quarry, Randsburg, and Hunters Trophy. DTRA sponsored all tests except Tomme and Randsburg which were sponsored by the Lawrence Livermore National Laboratory. Midnight Zephyr, sponsored by DTRA, was an add on experiment to the Tomme test. Eleven high explosive tests were also conducted in the tunnel and included a Stemming Plan Test, the Pre-Mill Yard test, the two seismic Non-Proliferation Experiment tests, and seven Dipole Hail tests. The U12n Tunnel complex is composed of the portal and mesa areas, encompassing a total area of approximately 600 acres (240 hectares). Major modifications to the landscape have resulted from four principal activities. These are road construction and maintenance, mining activities related to development of the tunnel complex, site preparation for activities related to testing, and construction of retention ponds. A total of 202 cultural features were recorded for the portal and mesa areas. At the portal area, features relate to the mining, construction, testing, and general everyday operational support activities within the tunnel. These include concrete foundations for buildings, ventilation

  11. The Kosice meteorite

    NASA Astrophysics Data System (ADS)

    Toth, J.; Svoren, J.

    2012-01-01

    Sciences (under the leadership of the second author), Comenius University in Bratislava (under the leadership of the first author), and the Czech Academy of Sciences (under the leadership of Pavel Spurny) started to sweep meadows and forests at the calculated area. The first meteorite was discovered by Juraj Toth on March 20th. By October 6th, 77 meteorite fragments were found. The heaviest fragment weighs 2.17 kg and was found by Tereza Krejcova; the smallest pieces were only about 0.5 g (finder Julius Koza). The total mass recovered is 4.3 kg. There were 28 finders: Juraj Toth, Diana Buzova, Marek Husarik, Tereza Krejcova, Jan Svoren, Julius Koza, David Capek, Pavel Spurny, Stanislav Kaniansky, Eva Schunova, Marcel Skreka, Dusan Tomko, Pavol Zigo, Miroslav Seben, Jiri Silha, Leonard Kornos, Marcela Bodnarova, Peter Veres, Jozef Nedoroscik, Zuzana Mimovicova, Zuzana Krisandova, Jaromir Petrzala, Stefan Gajdos, Tomas Dobrovodsky, Peter Delincak, Zdenko Bartos, Ales Kucera, and Jozef Vilagi. Preliminary as well as complex mineralogic analysis implies that the recovered meteorite is classified as an ordinary H5 chondrite (Dr. J. Haloda, Czech Geological Survey, D. Ozdin, and P. Uher, Comenius University in Bratislava). The authors are grateful to all collaborators mentioned above. More details about the meteorite will be published in the near future.

  12. Effects of disodium fumarate on ruminal fermentation and microbial communities in sheep fed on high-forage diets.

    PubMed

    Zhou, Y W; McSweeney, C S; Wang, J K; Liu, J X

    2012-05-01

    microbiota after adding DF. Ten of 15 clone sequences from cut-out bands appearing in both the 2nd and the 4th week were 94% to 100% similar to Prevotella-like bacteria, and four sequences showed 95% to 98% similarity to Selenomonas dianae. Another 15 sequences were obtained from bands, which appeared in the 4th week only. Thirteen of these 15 sequences showed 95% to 99% similarity to Clostridium sp., and the other two showed 95% and 100% similarity to Ruminococcus sp. In summary, the microorganisms positively responding to DF addition were the cellulolytic bacteria, R. albus, F. succinogenes and B. fibrisolvens as well as proteolytic bacteria, B. fibrisolvens, P. ruminicola and Clostridium sp. PMID:22558929

  13. Jet Power and Black Hole Assortment Revealed in New Chandra Image

    NASA Astrophysics Data System (ADS)

    2008-01-01

    acceleration in this part of the jet is unknown. Hundreds of point-like sources are also seen in the Chandra image. Many of these are X-ray binaries that contain a stellar-mass black hole and a companion star in orbit around one another. Determining the population and properties of these black holes should help scientists better understand the evolution of massive stars and the formation of black holes. Another surprise was the detection of two particularly bright X-ray binaries. These sources may contain stellar mass black holes that are unusually massive, and this Chandra observation might have caught them gobbling up material at a high rate. In this image, low-energy X-rays are colored red, intermediate-energy X-rays are green, and the highest-energy X-rays detected by Chandra are blue. The dark green and blue bands running almost perpendicular to the jet are dust lanes that absorb X-rays. This dust lane was created when Centaurus A merged with another galaxy perhaps 100 million years ago. This research was presented at the American Astronomical Society meeting on January 9th by Gregory Sivakoff (The Ohio State University). Other team members include Ralph Kraft (Harvard-Smithsonian Center for Astrophysics), Martin Hardcastle (University of Hertfordshire), Diana Worrall (University of Bristol), and Andres Jordan (Smithsonian Astrophysical Observatory). NASA's Marshall Space Flight Center, Huntsville, Ala., manages the Chandra program for the agency's Science Mission Directorate. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center in Cambridge, Mass.

  14. Obituary: John Louis Africano III, 1951-2006

    NASA Astrophysics Data System (ADS)

    Barker, Edwin, S.

    2007-12-01

    Technical Conference whose attendance expanded dramatically during his tenure. John moved to the NASA Johnson Space Center, Houston, Texas, in 1998 to work full time on orbital debris projects including the 3.0 meter Liquid Mirror Telescope and the CCD Debris Telescope in Cloudcroft, New Mexico. In 2000 he moved back to Colorado Springs, Colorado, to be closer to his family. From there he continued to support both the NASA Orbital Debris Program Office (ODPO) and AMOS. John was very instrumental in establishing cooperative programs between the ODPO and AMOS, which will benefit both organizations for many years to come. John left an indelible mark on his programs and all those who knew and loved him. The impact of his untimely departure will reverberate for many years. As John's wife Linda put it, "John is now visiting the stars and galaxies he adored from afar." John is survived by his wife, Linda Ann Africano; two sons, James Keith and Brian Michael; a daughter, Monica Lynn Africano; a sister, Diana Smith; and four grandchildren. The author acknowledges valuable input from Brian Africano (University of Colorado at Colorado Springs), Eugene Stansbery (NASA), Mark Mulrooney (NASA contractor), Tom Kelecy (Boeing LTS, Inc.), Paul Sydney (Boeing LTS, Inc.), Kira Abercromby (NASA contractor), and Patrick Seitzer (University of Michigan).

  15. PHYSICS EDUCATION AND THE INTERNET: A beginner's guide to a physicist starting out on an Internet journey

    NASA Astrophysics Data System (ADS)

    Burton, Paul

    1998-05-01

    -linehttp://www.shu.ac.uk/schools/sci/sol/contents.htm Physics humourhttp://quark.physics.uwo.ca/~harwood/humor12.htm Searching for someone's e-mail address?http://www.four11.com SKY publicationshttp://www.skypub.com Planet Sciencehttp://www.keysites.com New Scientisthttp://www.newscientist.com NASA links to the American space programhttp://www.nasa.gov NASA Jet Propulsion Laboratoryhttp://www.jpl.nasa.gov Hewlett-Packardhttp://www.hp.com The Bradford Schools Telescope Projecthttp://www.telescope.org/rti/nuffield/ To contact a professional societyhttp://www.lib.uwaterloo.ca/society/overview.html The Schools' Physics Group: post-16 issueshttp://diana.ecs.soton.ac.uk/~pm/Physics/post16.html Sleuth search for physics and chemistryhttp://www.isleuth.com/index.shtml The Particle Adventurehttp://pdg.lbl.gov/cpep/adventure_home.html Acknowledgments I thank colleagues David Robinson and Robin Peach for their help in selecting and validating these sites and William Try, pupil at Bootham School, for preparing and maintaining the department's homepage with hypertext links. Received 21 January 1998

  16. [State of food and nutritional care in public hospitals of Ecuador].

    PubMed

    Gallegos Espinosa, Sylvia; Nicolalde Cifuentes, Marcelo; Santana Porbén, Sergio

    2014-10-03

    para el uso de Nutrición artificial en la muestra de estudio, se le administró alguna de estas técnicas a solo el 2.5% (me diana de los porcentajes observados; rango: 1.3 – 11.9%) de los pacientes encuestados. Conclusiones: En el momento actual, el estado nutricional del paciente hospitalizado no se incluye dentro de los objetivos terapéuticos, los ejercicios de evaluación nutricional son incompletos, y la Nutrición artificial no se considera una opción terapéutica. De estos hallazgos solo se puede concluir que el nutricionista no ha encontrado cabida dentro del equipo de atención médica. Urge la adopción de las medidas requeridas para insertar las “Buenas Prácticas de Alimentación y Nutrición” dentro de la atención médica en los hospitales públicos del Ecuador.

  17. PREFACE: The IARU International Scientific Congress on Climate Change: Global Risks, Challenges and Decisions (10-12 March, Copenhagen, Denmark)

    NASA Astrophysics Data System (ADS)

    2009-01-01

    by the IARU universities In keeping with normal scientific practice, a procedure for producing the synthesis report that has been adopted optimises the chances of arriving at a product that will receive a broad backing from the scientific community as being a message that can be sent to the non-scientific community and that explains current understanding in climate change science The Writing Team will also be responsible for writing the book Members of the Writing Team (in alphabetical order) Professor Joe Alcamo, University of Stellenbosch Dr Terry Barker, Cambridge University Professor Daniel Kammen, University of California - Berkeley Professor Rik Leemans, Environmental Systems Analysis Group, Wageningen University Professor Diana Liverman, Oxford University Professor Mohan Munasinghe, Chairman, Munasinghe Institute for Development (MIND) Dr Balgis Osman-Elasha, Higher Council for Environment and Natural Resources (HCENR), Sudan Professor Katherine Richardson, University of Copenhagen Professor John Schellnhuber, Potsdam Institute for Climate Impact Research and visiting professor at the University of Oxford Professor Will Steffen, Australian National University Professor Lord Nicholas Stern, London School of Economics and Political Science (LSE) Professor Ole Wæver, University of Copenhagen 2 Key Messages from the Congress Key Message 1: Climatic Trends Recent observations confirm that, given high rates of observed emissions, the worst-case IPCC scenario trajectories (or even worse) are being realized For many key parameters, the climate system is already moving beyond the patterns of natural variability within which our society and economy have developed and thrived These parameters include global mean surface temperature, sea-level rise, ocean and ice sheet dynamics, ocean acidification, and extreme climatic events There is a significant risk that many of the trends will accelerate, leading to an increasing risk of abrupt or irreversible climatic shifts Key

  18. Mapping scientific frontiers : the quest for knowledge visualization.

    SciTech Connect

    Boyack, Kevin W.

    2003-08-01

    Visualization of scientific frontiers is a relatively new field, yet it has a long history and many predecessors. The application of science to science itself has been undertaken for decades with notable early contributions by Derek Price, Thomas Kuhn, Diana Crane, Eugene Garfield, and many others. What is new is the field of information visualization and application of its techniques to help us understand the process of science in the making. In his new book, Chaomei Chen takes us on a journey through this history, touching on predecessors, and then leading us firmly into the new world of Mapping Scientific Frontiers. Building on the foundation of his earlier book, Information Visualization and Virtual Environments, Chen's new offering is much less a tutorial in how to do information visualization, and much more a conceptual exploration of why and how the visualization of science can change the way we do science, amplified by real examples. Chen's stated intents for the book are: (1) to focus on principles of visual thinking that enable the identification of scientific frontiers; (2) to introduce a way to systematize the identification of scientific frontiers (or paradigms) through visualization techniques; and (3) to stimulate interdisciplinary research between information visualization and information science researchers. On all these counts, he succeeds. Chen's book can be broken into two parts which focus on the first two purposes stated above. The first, consisting of the initial four chapters, covers history and predecessors. Kuhn's theory of normal science punctuated by periods of revolution, now commonly known as paradigm shifts, motivates the work. Relevant predecessors outside the traditional field of information science such as cartography (both terrestrial and celestial), mapping the mind, and principles of visual association and communication, are given ample coverage. Chen also describes enabling techniques known to information scientists, such as

  19. News and Announcements

    NASA Astrophysics Data System (ADS)

    1999-05-01

    Supplementary Materials The number of supplementary materials that accompany print articles has grown and also become more varied. The new guidelines for lab experiments call for supplementary materials in most cases, so that the actual materials used in lab can be made available. The From Past Issues column edited by Kathryn Williams and many of the technology columns frequently have supplements for JCE Online. An especially interesting supplement that we would like to call to the attention of readers is a collection of videos from the E. O. Lawrence Berkeley National Laboratory, based on interviews with nuclear chemists who have discovered and studied the heaviest elements. These movies accompany the Viewpoints article, "Chemistry of the Heaviest Elements-One Atom at a Time" by Darleane C. Hoffman and Diana M. Lee. The titles of the movies are listed below; illustrative stills are shown at the bottom of the page. Researchers involved with the segments about Lawrencium include Robert Silva, Torbjorn Sikkeland, Matti Nurmia, Robert Latimer, and Albert Ghiorso, all of whom are from the Lawrence Berkeley Laboratory. (QuickTime 3 is needed in order to view the videos; it can be downloaded free from http://www.apple.com.)

    • A Brief Note about Plutonium, by Glenn Seaborg
    • Plutonium and Why It Was Kept a Secret
    • The Prediction of the Actinide Series, by Glenn Seaborg
    • First Chemical Separation of Lawrencium at Lawrence Radiation Laboratory in 1970
    • The HILAC or Heavy-Ion Linear Accelerator
    • Discovery of Lawrencium
    • How To Collect Lawrencium Atoms
    • The Discovery of Element 106-Finally
    • The Naming of Element 106
    • The Limits of Discovering the Heavy Elements
    • What Good Is a Heavy Element?
    To see these videos, view the Supplements of http://JChemEd.chem.wisc.edu/Journal/Issues/1999/Mar/abs331.html. People: Glenn Seaborg Glenn Seaborg, frequent contributor

  20. Genomes to Life Project Quartely Report October 2004.

    SciTech Connect

    Heffelfinger, Grant S.; Martino, Anthony; Rintoul, Mark Daniel; Geist, Al; Gorin, Andrey; Xu, Ying; Palenik, Brian

    2005-02-01

    .genomes-to-life.org Acknowledgment We want to gratefully acknowledge the contributions of the GTL Project Team as follows: Grant S. Heffelfinger1*, Anthony Martino2, Andrey Gorin3, Ying Xu10,3, Mark D. Rintoul1, Al Geist3, Matthew Ennis1, Hashimi Al-Hashimi8, Nikita Arnold3, Andrei Borziak3, Bianca Brahamsha6, Andrea Belgrano12, Praveen Chandramohan3, Xin Chen9, Pan Chongle3, Paul Crozier1, PguongAn Dam10, George S. Davidson1, Robert Day3, Jean Loup Faulon2, Damian Gessler12, Arlene Gonzalez2, David Haaland1, William Hart1, Victor Havin3, Tao Jiang9, Howland Jones1, David Jung3, Ramya Krishnamurthy3, Yooli Light2, Shawn Martin1, Rajesh Munavalli3, Vijaya Natarajan3, Victor Olman10, Frank Olken4, Brian Palenik6, Byung Park3, Steven Plimpton1, Diana Roe2, Nagiza Samatova3, Arie Shoshani4, Michael Sinclair1, Alex Slepoy1, Shawn Stevens8, Chris Stork1, Charlie Strauss5, Zhengchang Su10, Edward Thomas1, Jerilyn A. Timlin1, Xiufeng Wan11, HongWei Wu10, Dong Xu11, Gong-Xin Yu3, Grover Yip8, Zhaoduo Zhang2, Erik Zuiderweg8 *Author to whom correspondence should be addressed (gsheffe%40sandia.gov) 1. Sandia National Laboratories, Albuquerque, NM 2. Sandia National Laboratories, Livermore, CA 3. Oak Ridge National Laboratory, Oak Ridge, TN 4. Lawrence Berkeley National Laboratory, Berkeley, CA 5. Los Alamos National Laboratory, Los Alamos, NM 6. University of California, San Diego 7. University of Illinois, Urbana/Champaign 8. University of Michigan, Ann Arbor 9. University of California, Riverside 10. University of Georgia, Athens 11. University of Missouri, Columbia 12. National Center for Genome Resources, Santa Fe, NM Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  1. News & Announcements

    NASA Astrophysics Data System (ADS)

    1999-08-01

    years of Journal issues, available all the time with responses within seconds.

    ·Supplementary materials that are important to only a limited number of our subscribers; materials that augment laboratory experiments are a good example.

    ·Supplementary videos, such as the videos, still images, and excerpts from interviews with nuclear chemists that give fuller meaning to the Viewpoints article "Chemistry of the Heaviest Elements- One Atom at a Time" referred to below.

    ·Internet feature columns are more effective in a dynamic medium. Two that are in place are Mathcad in the Chemistry Curriculum (edited by Theresa Zielinski) and Conceptual Questions and Challenge Problems (edited by William Robinson and Susan Nurrenbern).

    ·Buyers Guides have their content updated often and link to other useful sites. There is one for books and software and another for supplies and equipment. Elements Added to Periodic Table Two new transuranic elements have been added to the list in the Viewpoints article "Chemistry of the Heaviest ElementsOne Atom at a Time" by Darleane C. Hoffman and Diana M. Lee (JCE, 1999, 76, 331). The new elements have atomic numbers 118 and 116. The path to the discovery of these elements was predicted by Robert Smolanczuk, a young Polish theorist whose calculations led him to conclude that a lead-krypton collision technique could produce element 118, which then decays to element 116. Others questioned his results, but Hoffman invited him to join the team at the Lawrence Berkeley National Laboratory and a decision was made to try out his ideas. The result was almost complete verification of Smolanczuk's calculations. The experimental team was headed by Kenneth E. Gregorich; Darleane Hoffman is one of 15 codiscoverers of element 118. Aw

  2. The Doryctinae (Braconidae) of Costa Rica: genera and species of the tribe Heterospilini

    PubMed Central

    Marsh, Paul M.; Wild, Alexander L.; Whitfield, James B.

    2013-01-01

    Abstract A comprehensive taxonomic study is presented for the four genera and 286 species of the doryctine tribe Heterospilini occurring in Costa Rica. The tribe is represented almost entirely by the 280 species of the genus Heterospilus Haliday. Keys for identification of the genera and species are provided and the genera and species are described and illustrated. An interactive key to the species of Heterospilus also was prepared using Lucid Builder. The following new genus and species are described from Costa Rica: Paraheterospilus gen. n., P. ceciliaensis sp. n., P. eumekus sp. n., P. wilbotgardus sp. n., Heterospilus achi sp. n., H. achterbergi sp. n., H. aesculapius sp. n., H. agujas sp. n., H. agujasensis sp. n., H. alajuelus sp. n., H. albocoxalis sp. n., H. alejandroi sp. n., H. amuzgo sp. n., H. angelicae sp. n., H. angustus sp. n., H. aphrodite sp. n., H. apollo sp. n., H. arawak sp. n., H. areolatus sp. n., H. artemis sp. n., H. athena sp. n., H. attraholucus sp. n., H. aubreyae sp. n., H. austini sp. n., H. azofeifai sp. n., H. bacchus sp. n., H. barbalhoae sp. n., H. bennetti sp. n., H. bicolor sp. n., H. boharti sp. n., H. borucas sp. n., H. braeti sp. n., H. brethesi sp. n., H. breviarius sp. n., H. brevicornus sp. n., H. bribri sp. n., H. brullei sp. n., H. bruesi sp. n., H. cabecares sp. n., H. cacaoensis sp. n., H. cachiensis sp. n., H. cameroni sp. n., H. cangrejaensis sp. n., H. careonotaulus sp. n., H. caritus sp. n., H. carolinae sp. n., H. cartagoensis sp. n., H. catiensis sp. n., H. catorce sp. n., H. cero sp. n., H. chaoi sp. n., H. chilamatensis sp. n., H. chocho sp. n., H. chorotegus sp. n., H. chorti sp. n., H. cinco sp. n., H. cocopa sp. n., H. colliletus sp. n., H. colonensis sp. n., H. complanatus sp. n., H. conservatus sp. n., H. cora sp. n., H. corcovado sp. n., H. corrugatus sp. n., H. costaricensis sp. n., H. cressoni sp. n., H. cuatro sp. n., H. curtisi sp. n., H. cushmani sp. n., H. dani sp. n., H. demeter sp. n., H. dianae sp

  3. The Doryctinae (Braconidae) of Costa Rica: genera and species of the tribe Heterospilini

    PubMed Central

    Marsh, Paul M.; Wild, Alexander L.; Whitfield, James B.

    2013-01-01

    Abstract A comprehensive taxonomic study is presented for the four genera and 286 species of the doryctine tribe Heterospilini occurring in Costa Rica. The tribe is represented almost entirely by the 280 species of the genus Heterospilus Haliday. Keys for identification of the genera and species are provided and the genera and species are described and illustrated. An interactive key to the species of Heterospilus also was prepared using Lucid Builder. The following new genus and species are described from Costa Rica: Paraheterospilus gen. n., P. ceciliaensis sp. n., P. eumekus sp. n., P. wilbotgardus sp. n., Heterospilus achi sp. n., H. achterbergi sp. n., H. aesculapius sp. n., H. agujas sp. n., H. agujasensis sp. n., H. alajuelus sp. n., H. albocoxalis sp. n., H. alejandroi sp. n., H. amuzgo sp. n., H. angelicae sp. n., H. angustus sp. n., H. aphrodite sp. n., H. apollo sp. n., H. arawak sp. n., H. areolatus sp. n., H. artemis sp. n., H. athena sp. n., H. attraholucus sp. n., H. aubreyae sp. n., H. austini sp. n., H. azofeifai sp. n., H. bacchus sp. n., H. barbalhoae sp. n., H. bennetti sp. n., H. bicolor sp. n., H. boharti sp. n., H. borucas sp. n., H. braeti sp. n., H. brethesi sp. n., H. breviarius sp. n., H. brevicornus sp. n., H. bribri sp. n., H. brullei sp. n., H. bruesi sp. n., H. cabecares sp. n., H. cacaoensis sp. n., H. cachiensis sp. n., H. cameroni sp. n., H. cangrejaensis sp. n., H. careonotaulus sp. n., H. caritus sp. n., H. carolinae sp. n., H. cartagoensis sp. n., H. catiensis sp. n., H. catorce sp. n., H. cero sp. n., H. chaoi sp. n., H. chilamatensis sp. n., H. chocho sp. n., H. chorotegus sp. n., H. chorti sp. n., H. cinco sp. n., H. cocopa sp. n., H. colliletus sp. n., H. colonensis sp. n., H. complanatus sp. n., H. conservatus sp. n., H. cora sp. n., H. corcovado sp. n., H. corrugatus sp. n., H. costaricensis sp. n., H. cressoni sp. n., H. cuatro sp. n., H. curtisi sp. n., H. cushmani sp. n., H. dani sp. n., H. demeter sp. n., H. dianae sp

  4. News and Announcements

    NASA Astrophysics Data System (ADS)

    1999-05-01

    Supplementary Materials The number of supplementary materials that accompany print articles has grown and also become more varied. The new guidelines for lab experiments call for supplementary materials in most cases, so that the actual materials used in lab can be made available. The From Past Issues column edited by Kathryn Williams and many of the technology columns frequently have supplements for JCE Online. An especially interesting supplement that we would like to call to the attention of readers is a collection of videos from the E. O. Lawrence Berkeley National Laboratory, based on interviews with nuclear chemists who have discovered and studied the heaviest elements. These movies accompany the Viewpoints article, "Chemistry of the Heaviest Elements-One Atom at a Time" by Darleane C. Hoffman and Diana M. Lee. The titles of the movies are listed below; illustrative stills are shown at the bottom of the page. Researchers involved with the segments about Lawrencium include Robert Silva, Torbjorn Sikkeland, Matti Nurmia, Robert Latimer, and Albert Ghiorso, all of whom are from the Lawrence Berkeley Laboratory. (QuickTime 3 is needed in order to view the videos; it can be downloaded free from http://www.apple.com.)

    • A Brief Note about Plutonium, by Glenn Seaborg
    • Plutonium and Why It Was Kept a Secret
    • The Prediction of the Actinide Series, by Glenn Seaborg
    • First Chemical Separation of Lawrencium at Lawrence Radiation Laboratory in 1970
    • The HILAC or Heavy-Ion Linear Accelerator
    • Discovery of Lawrencium
    • How To Collect Lawrencium Atoms
    • The Discovery of Element 106-Finally
    • The Naming of Element 106
    • The Limits of Discovering the Heavy Elements
    • What Good Is a Heavy Element?
    To see these videos, view the Supplements of http://JChemEd.chem.wisc.edu/Journal/Issues/1999/Mar/abs331.html. People: Glenn Seaborg Glenn Seaborg, frequent contributor

  5. News & Announcements

    NASA Astrophysics Data System (ADS)

    1999-08-01

    years of Journal issues, available all the time with responses within seconds.

    ·Supplementary materials that are important to only a limited number of our subscribers; materials that augment laboratory experiments are a good example.

    ·Supplementary videos, such as the videos, still images, and excerpts from interviews with nuclear chemists that give fuller meaning to the Viewpoints article "Chemistry of the Heaviest Elements- One Atom at a Time" referred to below.

    ·Internet feature columns are more effective in a dynamic medium. Two that are in place are Mathcad in the Chemistry Curriculum (edited by Theresa Zielinski) and Conceptual Questions and Challenge Problems (edited by William Robinson and Susan Nurrenbern).

    ·Buyers Guides have their content updated often and link to other useful sites. There is one for books and software and another for supplies and equipment. Elements Added to Periodic Table Two new transuranic elements have been added to the list in the Viewpoints article "Chemistry of the Heaviest ElementsOne Atom at a Time" by Darleane C. Hoffman and Diana M. Lee (JCE, 1999, 76, 331). The new elements have atomic numbers 118 and 116. The path to the discovery of these elements was predicted by Robert Smolanczuk, a young Polish theorist whose calculations led him to conclude that a lead-krypton collision technique could produce element 118, which then decays to element 116. Others questioned his results, but Hoffman invited him to join the team at the Lawrence Berkeley National Laboratory and a decision was made to try out his ideas. The result was almost complete verification of Smolanczuk's calculations. The experimental team was headed by Kenneth E. Gregorich; Darleane Hoffman is one of 15 codiscoverers of element 118. Awards Willard Gibbs Medal Lawrence F. Dahl of the University of Wisconsin-Madison is the recipient of 1999 Willard Gibbs Medal, the highest award of the