Examination of Cement Pastes Hydrated Phases, and Synthetic Products by X-Ray Diffraction

DTIC Science & Technology

1972-04-01

International Union o, Crystallography Commission on Crystallo- graphic Data, Powder Data, Journal of Applied Crystallography, Vol 4, pp 81-86, 1971 . 21...Papes, Research Series 1, Building Research Station, 1962. 25. l,, Dosch, Rbntgen-Ceinstrukturuntersuchu , luftemp’indlicher pulverprlparate, Zement- Kall

When the Japanese Bombed the Huertgen Forest: How the Army’s Investigation of Pearl Harbor Influenced the Outcome of the Huertgen Forest, Major General Leonard T. Gerow and His Command of V Corps from 1943-1945

DTIC Science & Technology

2011-05-19

only a narrow supply line that passed along a narrow one-lane path called the Kall Trail.13 The Germans mounted fierce counter-attacks well supported...Bradley. New York: Ballantine Books, 1971 . ________. West Wall: The Battle For Hitler’s Siegfried Line. Conshohocken, PA.: Da Capo Press, 2000

A Critical Comparison of Some Methods for Interpolation of Scattered Data

DTIC Science & Technology

1979-12-01

because faster evaluation of the local interpolants is possible. KAll things considered, the method of choice here seems to be the Modified Quadratic...topography and other irregular surfaces," J. of Geophysical Research 76 ( 1971 ) 1905-1915I’ [23) HARDY, Rolland L. - "Analytical topographic surfaces by

Conducting Studies of Transfer of Learning: A Practical Guide

DTIC Science & Technology

1982-01-01

X) = percent transfer (If learning C where: Kall aicrage of grades assigned to experimental :.ttmdents for p~erformlanlce in the aircraft. an average...effectiveness. Human Factors. 1971 . 13(6). 561-567. Roscoe, S.N. A little more on incremental transfer effectiveness. Human Factors. 1972, 14(4), 363-364

Sublinear Upper Bounds for Stochastic Programs with Recourse. Revision.

DTIC Science & Technology

1987-06-01

approximation procedures for (1.1) generally rely on discretizations of E (Huang, Ziemba , and Ben-Tal (1977), Kall and Stoyan (1982), Birge and Wets...Wright, Practical optimization (Academic Press, London and New York,1981). C.C. Huang, W. Ziemba , and A. Ben-Tal, "Bounds on the expectation of a con

Numerical and Experimental Investigation of Multiple Shock Wave/Turbulent Boundary Layer Interactions in a Rectangular Duct

DTIC Science & Technology

1988-01-06

the bottom % kall followin,, the interaction. At 6Wuh = 0.35 the shock train would not stay attached to a single wall long enough for the surface...Interaction of a Shock Wave with a Laminar Boundary Layer," Lecture Notes in Physics, Vol. 8, Springer-Verlag, 1971 , pp. 151-163. 51 MacCormack, R. W

The Transient Excitation and Oscillation Testing Technique Applied to a Captive Model.

DTIC Science & Technology

1981-06-01

8217Kall io I 9. PERFORMING ORGANIZATION NAME AND ADDRESS PROGRAM ELEMENT. PROJECT, TASK David W. Tayl.or Naval Ship Research and -OW UNIT NUMBERS...corrective tare terms (C’. 11 C35’ C 53 and C 55) used in calculating the nondimensional oscillat ion coff ticient s. Figures 7--14 contain comparisons of

Issues Related to Recruitment of Enlisted Personnel for the Reserve Components. Volume 3. Methods Volume. Wave III.

DTIC Science & Technology

1981-03-01

OO3 b’ As.nciates for Rusearch in Behavior, 1971 -- 1978. O -3- TABLE 1-1. PRIOR SERVICE SUBSAINPLE SIZES PRIOF SERVICE AMEFS =NAMES# SUBSAYPLE...BLK.266 ST.36 SRVC, kALL DATE TIME INTERV RESULT GCNZALEZNELSOh ANINIC, I- r 111-17 167 ST 2 JAMAICA NV 11433 2 / __ 0 3 4 NA BY CB c B -I

Installation Restoration Program. Phase II - Confirmation/Quantification. Stage 1 for American Lake Garden Tract, Washington.

DTIC Science & Technology

1985-12-20

Kalles . 1976. Evaporation rates of methylene chloride, chloroform, 1,1,1-trichloroethane, trichloroethylene, tetrachoroethylene, and other chlorinated...State University (1969) M.S., Geology, University of Washington ( 1971 ) . . Ph.D., University of Washington (1979) " EXPERIENCE 1984 to Date Senior...ducted environmental assessments for Pacific Northwest construc- tion projects. L- 1971 Project Geologist, SEREM of Alaska (BRGM-France). Responsibil

Coherent Plasmon-Exciton Coupling in Silver Platelet-J-aggregate Nanocomposites

DTIC Science & Technology

2015-02-27

2011, 11, 1556−1560. (12) Zengin, G.; Johansson, G.; Johansson, P.; Antosiewics, T. J.; Kall , M.; Shegai, T. Sci. Rep. 2013, 3 (3074), 1−8. (13...Mater. 2005, 17, 412−415. (21) Davydov, A. S. Theory of Molecular Excitons; Plenum Press: New York, 1971 . (22) Van Burgel, M.; Wiersma, D. A.; Duppen, K

Forecast of Future Ohio River Basin, Waterway Traffic Based on Shippers Surveys.

DTIC Science & Technology

1979-09-01

pattern. Analytic Tool: SPSS KAll of the editing, generation of tables, graphing, and other com- putational activities were carried out through the use...00O’s) 1976-1g90 Group 1971 1990 (%) 1976 190 (9) Coal & Coke 0 0 0 1,617 3,231 +100 Petroleum Fuels 705 779 +10 509 509 +0 Aggregates 0 0 0 450 688

Inventory of Archaeological and Historical Resources Lava Flow Control Study, Hilo, Hawaii,

DTIC Science & Technology

1979-05-01

amale- p 11111 S.PIaN. Sitea card; hial. 1971 :2 aa. INVENTRh Y OF AIIAj4AOLGICAL AND HISIORICAL ESItIMCES Sit umber Site Ded𔃻ption e Period Coed...liaison. 1932:294 SO-a-Al-ST Kalled , paved 4 PPI.Site Card; NHudson, 1932:29S.2W6 terraced platorm bo-Li-AI. 55$ Legendary crevite, Esrsaa% 1903:Is

Wartime Requirements for Ammunition Materiel and Personnel (WARRAMP). Volume II. Materiel Postprocessor Program Maintenance Manual

DTIC Science & Technology

1981-08-01

00 .1 00 -0 71: 3.1%2 7.460 . 30 1.0 0 .950 AS .1491 .? 0o -T 00 .8 72: G3: 70; ARTY KALLS FATORS B0 050BR CAS T ERO 7?211 .000 1.70 .000 I.000 .1500...Administrative and Logistic Support (FASTALS), Documentation, Research Analysis Corporation, RAC-R-86, dated May 1971 . F. Army Automation, Documentation Standards

STAMMER2 Production System for Tactical Situation Assessment. Volume 2. Code.

DTIC Science & Technology

1979-10-01

1961 (WITHINR * [NLAMBDA L (*NOBIND ൖ-Nov-78 19:25") (NCONC WITHINRFNS L) (MAKEFILE (QUOTE WITHINR.LSP]) [ 1971 (CROSSPATHS [LAMBDA (Si S2 TI T2)V...176 46. 1 I 1 FKACS 47. 1 I FKSYM (221 48. 1 FKIDPB 49. I M KALL (9) 50. 1 DSPTTY FKCALL (9) 51. I 1 FKJSYS (3) 52. 1 1 1 DSPTTYSTR DECSAMEDIGITS {bl

The accuracies of DNA-based estimates of genetic merit derived from Angus or multibreed beef cattle training populations.

PubMed

Weber, K L; Drake, D J; Taylor, J F; Garrick, D J; Kuehn, L A; Thallman, R M; Schnabel, R D; Snelling, W M; Pollak, E J; Van Eenennaam, A L

2012-12-01

Several organizations have developed prediction models for molecular breeding values (MBV) for quantitative growth and carcass traits in beef cattle using Bovine SNP50 genotypes and phenotypic or EBV data. Molecular breeding values for Angus cattle have been developed by IGENITY, Pfizer Animal Genetics, and a collaboration between researchers from Iowa State University and the University of Missouri-Columbia (ISU/UMC). The U.S. Meat Animal Research Center (USMARC; Clay Center, NE) has also developed MBV for 16 cattle breeds using 2 multibreed populations, the Germplasm Evaluation (GPE) Program and the 2,000 Bull Project (2K(ALL)), and 2 single breed subpopulations of the 2,000 Bull Project, Angus (2K(AN)) and Hereford (2K(HH)). In this study, these MBV were assessed relative to commercial ranch EBV estimated from the progeny phenotypes of Angus bulls naturally mated in multisire breeding pastures to commercial cows: 121 for USMARC MBV, 99 for ISU/UMC MBV, and 29 for IGENITY and Pfizer MBV (selected based on number of progeny carcass records). Five traits were analyzed: weaning weight (WW), HCW, marbling score (MS), rib-eye muscle area (RE), and, for IGENITY and Pfizer only, feedlot ADG. The average accuracies of MBV across traits were 0.38 ± 0.05 for IGENITY, 0.61 ± 0.12 for Pfizer, 0.46 ± 0.12 for ISU/UMC, 0.16 ± 0.04 for GPE, 0.26 ± 0.05 for 2K(ALL), 0.24 ± 0.04 for 2K(AN), and 0.02 ± 0.12 for 2K(HH). Angus-based MBV (IGENITY, Pfizer, ISU/UMC, and 2K(AN)) explained larger proportions of genetic variance in this population than GPE, 2K(ALL), or 2K(HH) MBV for the same traits. In this data set, IGENITY, Pfizer, and ISU/UMC MBV were predictive of realized performance of progeny, and incorporation of that information into national genetic evaluations would be expected to improve EPD accuracy, particularly for young animals.

Propagation of Sound Through the Atmosphere: Effects of Ground Cover

DTIC Science & Technology

1978-06-19

Over Simulated Ground Cover", J. Acoust. Soc. Am. 49, 1069-1075 ( 1971 ). 8 J. . . Piercy, T. F. W. Embleton, and L. C. Sutherland, "A Review of Noise...FlPST., AM KALL C AND SUBMOUTINL NAIAE *𔃺’t.ATfl"v hISTTAD 0t "COPPIS?". C PANG4N IS Ali tUIT 01* IAANG4Kp [XCLUSVIfo UT NTt.14VENINC, Fj)ITSq C RANG

Archaeological Investigations at Site 45-OK-11, Chief Joseph Dam Project, Washington.

DTIC Science & Technology

1984-01-01

Russian thistle (_Iol]L kALL ), and thistle ( r_ _ium spp.) among others. Scattered sagebrush and rabbitbrush . (Chrysothamnus nauseosus), and a dense...described in detail selectively. All artifact analyses take the form of paradigmatic classifications as defined by Dunnell ( 1971 , 1979). In this system...with certain methods of production and particular steps in the reductive sequence (e.g., Crabtree 1972, 1976a,b; Flenniken and Garrison 1975; Muto 1971

Chance Constrained Programming Methods in Probabilistic Programming.

DTIC Science & Technology

1982-03-01

Financial and Quantitative Analysis 2, 1967. Also reproduced in R. F. Byrne et. al., eds.5tudies in Budgeting (Amsterdam: North Holland, 1971 ). [3...Rules for the E-Model of Chance-Constrained Programming," Management Science, 17, 1971 . [23] Garstka, S. J. "The Economic Equivalence of Several...Iowa City: The University of Iowa College of Business Administration, 1981). -3- (29] Kall , P. and A. Prekopa, eds, Recent Results in Stochastic

Cardiorespiratory Changes During Microwave-Induced Lethal Heat Stress and Beta-adrenergic Blockade

DTIC Science & Technology

1994-01-01

J. A. Taylor, J. K . Kalls , J. Nit- verse these responses. Fundam. Appl. Toxicol. 10- 506-516, 1988. tolo, R. W. Hicks, T. G. Lohmnan, and J. H...propanolol groups were significantly lower than in saline controls. Respiratory rate was significantly elevated during most of the exposure period in...lar and respiratory changes) during lethal exposures. Al- propranolol groups were significantly lower than in saline con- though the pathophysiology

Remotely Piloted Vehicles Design Option Decision Trees

DTIC Science & Technology

1975-06-01

of Lrade-off options available before inception of hardware design (Askren and Korkan, 1971 ; Askren, Korkan, and Watts, 1973). The purpose of the study...bouso~ENGIN LAVEIVESi SLIPSTRCA LAS? SOURCE HIGH LIFT DEVICE$ FLAPS SIGESO GRACES~~~ -AULILESOrCTER kALL T RCD TEMPERATUR EQUIPNENT COS,.UV...Method for Relating Human Resources Data to Design Parameters, AFHRL-TR-71-52, December 1971 . Barnes, B.P., Baker, L.A., and McIntosh, B.E., The

Development and Evaluation of a Casualty Evacuation Model for a European Conflict.

DTIC Science & Technology

1987-08-18

W Applications and Computations," lIE Transactions, 16, 2, 127-134 "- ( 1984 ).-,’’ ,., 3. Ali, A. I., Helgason, R. V., Kennington, J. L., and kall ...Part II," Mathematical Programming, 1, 6-25 ( 1971 ). 38. Held, M., Wolfe, P., and Crowder, H., "Validation of Subgradient Optimization", Mathematical...California, Los Angeles, CA, ( 1971 ). Si 66. Swoveland, C., "A Two-Stage Decomposition Algorithm for a Generalized Muticommodity Flow Problem," INFOR

Man-Machine Interface (MMI) Requirements Definition and Design Guidelines

DTIC Science & Technology

1981-02-01

be provided to interrogate the user to resolve any input ambiguities resulting from hardware limitations; see Smith and Goodwin, 1971 . Reference...Smith, S. L. and Goodwin, N. C’. Alphabetic data v entry via the Touch-Tone pad: A comment. Human Factors, 1971 , 13(2), 189-190. 41 All~ 1.0 General (con...software designer. Reference: Miller, R. B. Response time in man-computer conversational transactions. In Proceedings of the AFIPS kall Joint Computer

Radio Wave Propagation: A Handbook of Practical Techniques for Computing Basic Transmission Loss and Field Strength

DTIC Science & Technology

1982-09-01

MARK A. WEISSBEGU KALLE R. XONTSON Project Msnaqer, IUTRZ Assistant Director Contractor Operations Approved by CRARLES L. FLYNN, 001, us A. M. MESSE...34 BSTJ, 1946. 2-4priis, H.T., "Introduction to Radio and Antennas," IEEE Spectrum, April, 1971 . RADIO WAVE PROPAGATION: A HANDBOOK OF PRACTICAL...Propagation Tests, TR-0177-71.01, Gautney & Jones Communications, Inc., Falls Church, VA, June 1971 . 3 -7 Comparison of Predicted VLF/LF Signal

Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles

DTIC Science & Technology

2006-06-01

Rangel, R.; Sun, Y.; Zaoui, K.; Schmidt, M.; Kalle, C. v.; Weitzman, M. D.; Gelovani, J. G.; Pasqualini , R.; Arap, W., A Hybrid Vector for Ligand...A.; Holbeck, S. L.; Sausville, E. A.; Arap, 7 W.; Pasqualini , R., Ligand-Directed Surface Profiling of Human Cancer Cells with Combinatorial...Ozawa, M. G.; Snyder, E. Y.; Sidman, R. L.; Miller, J. H.; Arap, W.; Pasqualini , R., Networks of gold nanoparticles and bacteriophage as biological

High Mobility Driver Performance Analysis

DTIC Science & Technology

1981-06-01

Adjusted Residuals 25 Table 13. Trials kAll Trials Including Civilian Drivers) During which Critical Incidents Occurred (Or Did Not Occur) 26 Table 14...0.05 (Winer, 1971 )3. At, the close of training an error score had been selected from amons alternative formulations as reasonably representative of...USNPA, Aug 1968. Winer, B. J. Statistical Principles in Experimental Design. Second (2d) edition. McGraw-Hill, New York, 1971 . 35 IN hi a. I i d A-14

JPRS Report West Europe

DTIC Science & Technology

1988-08-12

that first graders are the nicest, like all in one big family. Well-behaved and obedient. Maybe Matti teases Maija a little bit and Pekka pushes Kalle ...France as early as 1971 . The system designed for Finland is an all-weather ver- sion and it was originally intended to specifically destroy low-flying...ISTAT study covers principally the three years of 1984-86, but also examines the evolution of crime in Italy since 1971 . And this could not have

Selectivity of Odorant Receptors in Insects

DTIC Science & Technology

2012-07-13

Regnier, 1971 ), which is equivalent to an endogenous agonist, may be expanded to include the following criteria: 1. Semiochemicals are natural...journal.pone.0030304 Law, J. H., and Regnier, F. E. ( 1971 ). Pheromones. Annu. Rev. Biochem. 40, 533–548. Lu, T., Qiu, Y. T., Wang, G., Kwon, J. Y...malaria vector mosquito Anopheles gambiae. Curr. Biol. 17, 1533–1544. Lundin, C., Kall , L., Kreher, S. A., Kapp, K., Sonnhammer, E. L., Carlson, J. R

Survivability Study of a FLIR Equipped Fighter on a Night Penetration of a Soviet Army.

DTIC Science & Technology

1981-03-01

4L TATL KALL . .5500E.1 .:02SE+I .55015E+00 .I 1E+II .II#E+#Z it 102 ’I" ADnend i x ( RANG;ES Comni r er 1’rn rqm Thft; nrnpram rnmniitpq the r ximum...VEL SIGMA .584 1 .514 .097 .756 1971 = ALT SIGMA 142.675 2 71.337 13.724 ,W91 1080= 1690= 3-WAY INTERACTIONS 52.133 16 3.258 .627 .868 1I#= NET RATE VEL

Revegetation Study of Adobe Dam, Phoenix, Arizona. Task 2. Revision.

DTIC Science & Technology

1983-08-01

revegetation. *~ ~ A DDoa or?, I47 MDTOOOV 65IS OBSOLETE SECURITY CLASSIFICATION OF THIS PAGE (Wh"e Ders, Enreedl k ’, ... . .- r77. -. r - -V...addition to sodic soils, five sites along the wash were discovered to have salinity problems, with electrical conductivity in excess of 4. mmhos/cm. This...established at Indian Bend Wash.This species, along with Salla kalL (Tumbleweed) made upthe majority of the vegetation in 1979. Since 1979, as thedata in

A Synopsis of the Chemical/Physical Properties of Seawater

DTIC Science & Technology

1988-01-01

N20 -59.5965 97.3066 24.1406 -0.058420 0.033193 -0.0051313 4 1Weiss (1970), 2Weiss ( 1971 ), 3 Wiesenburg and Guinasso (1979), 4 Weiss and Price...20 30 40 50 60 70 80 90100 Temperature ( ° C) FIG. 5. Velocity of light in pure water and seawater as a function of temperature, from Kalle (1942...of Sheet Pile Structures, from U.S. Navy Design Manual ( 1971 ). Types of structure Factors affecting deterioration Harbor bulkheads Beach bulkheads

Solution Methods for Stochastic Dynamic Linear Programs.

DTIC Science & Technology

1980-12-01

16, No. 11, pp. 652-675, July 1970. [28] Glassey, C.R., "Dynamic linear programs for production scheduling", OR 19, pp. 45-56. 1971 . 129 Glassey, C.R...Huang, C.C., I. Vertinsky, W.T. Ziemba, ’Sharp bounds on the value of perfect information", OR 25, pp. 128-139, 1977. [37 Kall , P., ’Computational... 1971 . [701 Ziemba, W.T., *Computational algorithms for convex stochastic programs with simple recourse", OR 8, pp. 414-431, 1970. 131 UNCLASSI FIED

The Combined Arm Battalion and Airland Battle,

DTIC Science & Technology

1986-12-01

through Vossenach, across the Kall River, and on to Kommerscheidt and Schmidt. Although this trail was the major route for reinforcements and resupply...the division. The use of armor in support of the operation wa3 al-ii oo. Tanks were unable to traverse the narro)w and steeply ba:iked K .-il River...from the 53rd Armored Infantry Battalion opened up the bridgehead over the Moselle River in the initial movement towards ChateaU- 48 Salins . In this

Vector/Matrix Quantization for Narrow-Bandwidth Digital Speech Compression.

DTIC Science & Technology

1982-09-01

8217o 0 -X -u -vc "oi ’" o 0 00i MN nM I -r -: I I Ir , I C 64 ut c 4c -C ;6 19I *~I C’ I I I 1 Kall 9 I I V4 S.0 M r4) ** al Iw* 0 0 10* 0 f 65 signal...Prediction of the Speech Wave, JASA Vol. 50, pp. 637-655, April 1971 . - 2. I. Itakura and S. Saito, Analysis Synthesis Telephony Based Upon the Maximum

Wavevector-Frequency Analysis with Applications to Acoustics

DTIC Science & Technology

1994-01-01

Turbulent Boundary Layer Pressure Measured by Microphone Arrays," Journal of the Acoustical Society of America, vol. 49, no. 3, March 1971 , pp. 862-877. 1...ARplications of Green’s FuntionsinScie,.-and Enginlering, Prentice-Hall, Inc., Englewood Hills, NJ, 1971 . 9. 3. Ffowcs-Williams et al., Modern Methods for...variables of a random process are kalled Joint w.merit ,. The m,n-th joint moment of the random variables, v and w, iz flefined by E ,N 1 f (aB) do d- where

Regenerative Simulation of Response Times in Networks of Queues.

DTIC Science & Technology

1979-11-01

i jobs at center 1. Nov consider the network of queues in Figure 2.2, formulated (Lewis and Shedler ( 1971 )) as a model of system overhead in...7.2 leading to point estimates and confidence intervals for the quantity r(f) are that the pairs of random variables {( V(fHk) : kall (9.2.3) are...189 Next we show that P’=P. Since P ’m"CIP for all i, we can use the Skorohod representation theorem (see Skorohod (1956) or Billingsley ( 1971 )) to

NPS-PASCAL. A Microcomputer-based Implementation of the PASCAL Programming Language.

DTIC Science & Technology

1980-03-01

rCL (N BASED PRINTNAME)(1) BTEV; CALL LI ’ ITS (I: =N (0)4-7); CALL 7NTEmRtLINKS; 12%- CALL ST A DrRT ( ); PY’EPTR(e)= FOR" kALL S7ET.DDRPTR(!K...kAccI, 1971 . 7* Flynn.,C P. and Moranville, .S., kL-;T_-v0 T -Dl1e7-itaticn Cf A Fi-I 1-vel 3o tt~ lanr’uape F-cr A M’icroccssor-bs- C~’-:uter Sy st

A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App.

PubMed

Brinker, Titus Josef; Enk, Alexander; Gatzka, Martina; Nakamura, Yasuhiro; Sondermann, Wiebke; Omlor, Albert Joachim; Petri, Maximilian Philip; Karoglan, Ante; Seeger, Werner; Klode, Joachim; von Kalle, Christof; Schadendorf, Dirk

2017-09-21

This viewpoint reviews the perspectives for dermatology as a specialty to go beyond the substantial impact of smoking on skin disease and leverage the impact of skin changes on a person's self-concept and behavior in the design of effective interventions for smoking prevention and cessation. ©Titus Josef Brinker, Alexander Enk, Martina Gatzka, Yasuhiro Nakamura, Wiebke Sondermann, Albert Joachim Omlor, Maximilian Philip Petri, Ante Karoglan, Werner Seeger, Joachim Klode, Christof von Kalle, Dirk Schadendorf. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 21.09.2017.

Uranium Oxide Gaseous Ion and Neutral Infrared Spectroscopy

DTIC Science & Technology

1983-12-31

Kallelis , and q technical advice received from Drs. Charles E. Kolb, Kurt Annen, Alan Stanton, * and Mark Zahniser of Aerodyne and G. Sargent Janes of Avco...Chem. 75, ( 1971 ) 2283. - S6. S. Abramowitz and N. Acquista, J. Phys. Chem. 76, (1972) 647. 7. H.J. Leary, Jr., T.A. Rooney, E.D. Cater, and ll.B...Friedrich, High Temp. Scd. 3, ( 1971 ) 433. 8. D.H.W. Carstens, D.M. Gruen, and J.F. Kozlowski, High Temp. Sed. 4, 436 (1972). 9. a) M.J. Krauss and W.J

Pleiotrophin as a Growth Factor and Therapeutic Target in Breast Cancer

DTIC Science & Technology

1997-10-01

novel phospholipase A2 related gene. Nucl Acid Res 21:135-143. 11. Gattoni-Celli, S., K . Kirsch, S. Kalled , and K . J. Isselbacher. 1986. Expression...clone (G11-F7) is enlarged. Genomic Southern blot probes (a,b,c) and restriction sites are shown (B=BamHI, H=HindIII, Sc=ScaI, K =KpnI). 10WJ 3fr 4&V...otherwise in 25 mM Tris pH8.3/200 mM glycine/20% methanol. The membrane was blocked in PBS (phospate-buffered saline )/0.1% Tween 20/5% powdered milk and

Oxidation of Thiodiglycol (2,2’-Thiobis-ethanol) by Alcohol Dehydrogenase: Comparison of Human Isoenzymes

DTIC Science & Technology

2000-01-01

Ethanol by ADH Isozymes0 Isozyme TDC Ethanol Class K „ b *cat/-Nn K , *cat Kall ^m I act 8.6 (7.9 ± 1.2)e 63 7 4.2 54 13 PiPi 3.5 (4.2 ± 0.4) 34 8 0.05...the appropriate concentration of substrate in 0.85% saline was added. The reaction was followed by measuring the change in absorbance at 340 nm...ß2ß2 from Kedishvili et al. [271. * K „ values obtained from Lineweaver-Burk plots (Figure 1). ’Values in parentheses are X„s ± S.E. calculated from

Numerical Methods for Synoptic Computation of Oceanic Fronts and Water Type Boundaries and their Significance in Applied Oceanography

DTIC Science & Technology

1966-06-01

and L. C. Clarke 1965 Clarke, L. C. and R. J. Renard 1966 Dietrich, G. and K . Kalle 1957 Dietrich, G. 1964 Griffiths, R. C. 1965 Hela...8217s n AppA. 1 (sd LiceanGgrapny« (9) T s c h n 1 ’■■- a i. n Q ’z.e , ■: 10) Ci Bf k e , I..... ^ i-’ •■ (10) i...aevastu , i . ill) J u...only between water masses of different salinity but also between those differing in other properties, such as temperature." The nature of the oceanic

Impact of 1/8 degree to 1/64 degree Resolution on Gulf Stream Model-Data Comparisons in Basin-Scale Subtropical Atlantic Ocean Models

DTIC Science & Technology

2000-01-01

Momentum Fluxes. NOAA Atlas NESDIS 8 vol. 3 US Department of Commerce, NOAA, NESDIS, 413 p. Dietrich, G., Kalle , K ., Krauss, K ., Siedler, G., 1980...depth, hydrodynamic model are given below for layers ks1 . . . n with ks1 for the top layer. In places where k is used to index model interfaces, ks0 is...the surface and ksn is the bottom. EU 1 E U u E V u cosuŽ . Ž . k k k k k q q yV u sinuqaV sin2uŽ . k k Et acosu Ef Eu sqmax 0,yv u qmax 0,v u y max 0

Short Trips and a Traverse

NASA Technical Reports Server (NTRS)

Cameron, Richard

2012-01-01

Dr. Cameron joined the Arctic Institute of North America in 1956 to participate in IGY-related activities in Antarctica. He served as Chief Glaciologist at Wilkes Station, on the coast of East Antarctica. This was a joint Navy-civilian operation consisting of 17 Navy personnel and 10 scientists. Specifically, his glaciological team consisted of two colleagues with whom he had worked before - Olav Loken in Norway in the summer of 1953, and John Molholm in Greenland in the summer of 1954. This team spent much of its time at a remote station established 80 kilometers (50 miles) inland, where they conducted both meteorological and glaciological studies. One of the glaciological studies entailed digging a 35-meter (approx.115-foot) vertical pit to study snow densification and stratigraphy. The assignment for the Navy Seabees was to first establish a joint US-NZ base at Cape Hallett and then go along the coast of East Antarctica and set up Wilkes Station.

Bullying behaviour among Norwegian adolescents: psychiatric diagnoses and school well-being in a clinical sample.

PubMed

Hansen, Hanne Hoff; Hasselgård, Cecilie Edh; Undheim, Anne Mari; Indredavik, Marit Sæbø

2014-07-01

Few studies have focused the association between bullying and psychiatric disorders in clinical samples. The aim of this study was to examine if bullying behaviour was associated with psychiatric disorders and school well-being. The cross-sectional study was part of a health survey at St. Olav's University Hospital. The sample consisted of 685 adolescent patients aged 13-18 years who completed an electronic questionnaire. Clinical diagnoses were collected from clinical records. In this clinical psychiatric sample, 19% reported being bullied often or very often, and 51% reported being bullied from time to time. Logistic regression analyses showed associations between being a victim and having a mood disorder, and between being involved in bullying behaviour and reporting lower scores on school well-being. No difference was found in bullying behaviour on gender, age and SES. The risk of being a victim was high among adolescents in this clinical sample, especially among patients with mood disorders. Any involvement in bullying behaviour was associated with reduced school well-being.

Davis Monthan AFB Tucson, Arizona. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1976-07-01

ATA PRUCCSSING BRANC𔃾 UAF ElA CEILING VERSUS VISIBILITY +-AIR W/ kAll ’ , SIRVICEI/1iC 2JIU9 D, V1S MU 1IMA, AFB AkIZONAUC51UCI) ,)-45peif8-75 DEC 5T+O... 1971 蔵 69j "l 1 .74 681 0 2 2 626 103 -42/;Ol3j 14 - 1120 L -,AN 4--- - -- - 27, 313 ____ ____- --- K -- --±-183 ni n 166 42 mn Wkl I _ 1 1...161 1971 187 5 1 541 53 1 1 .2 . .4 .1 .7 l.3 .4 .7 #. 1 1__6 L 1_0 11 2 58/ 47,*00 0 0 94 *l .2 iol2 5-- 49 .Q .49 . .7 .6 .7 .5 o0 10_

Summary of Meteorological Observations, Surface (SMOS), Midway Island.

DTIC Science & Technology

1984-08-01

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Patient-Centered Mobile Health Data Management Solution for the German Health Care System (The DataBox Project).

PubMed

Brinker, Titus Josef; Rudolph, Stefanie; Richter, Daniela; von Kalle, Christof

2018-05-11

This article describes the DataBox project which offers a perspective of a new health data management solution in Germany. DataBox was initially conceptualized as a repository of individual lung cancer patient data (structured and unstructured). The patient is the owner of the data and is able to share his or her data with different stakeholders. Data is transferred, displayed, and stored online, but not archived. In the long run, the project aims at replacing the conventional method of paper- and storage-device-based handling of data for all patients in Germany, leading to better organization and availability of data which reduces duplicate diagnostic procedures, treatment errors, and enables the training as well as usage of artificial intelligence algorithms on large datasets. ©Titus Josef Brinker, Stefanie Rudolph, Daniela Richter, Christof von Kalle. Originally published in JMIR Cancer (http://cancer.jmir.org), 11.05.2018.

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.

PubMed

Robles, Ana I; Olsen, Karina Standahl; Tsui, Dana W T; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B; Krokan, Hans E; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf D

2016-10-19

The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The "1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation and Implementation", was held June 16th and 17th 2016, at the Knowledge Center of the St. Olavs Hospital in Trondheim, Norway, under the auspices of the Norwegian University of Science and Technology (NTNU) and the HUNT biobank and research center. The Symposium attracted approximately 100 attendees and invited speakers from 12 countries and 4 continents. In this Symposium original research and overviews on diagnostic, predictive and prognostic cancer biomarkers in serum, plasma, urine, pleural fluid and tumor, circulating tumor cells and bioinformatics as well as how to implement biomarkers in clinical trials were presented. Senior researchers and young investigators presented, reviewed and vividly discussed important new developments in the field of clinical biomarkers of cancer, with the goal of accelerating biomarker research and implementation. The excerpts of this symposium aim to give a cutting-edge overview and insight on some highly important aspects of clinical cancer biomarkers to-date to connect molecular innovation with clinical implementation to eventually improve patient care.

Hoechst and Wacker plan joint venture in PVC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Young, I.

1992-12-02

Restructuring of Europe's petrochemical industry has taken a further step with the announcement that Hoechst (Frankfurt) and Wacker Chemie (Munich) are planning a joint venture in polyvinyl chloride (PVC). The venture would include production, R D, sales and marketing, plus both companies' PVC recycling activities. However, their vinyl chloride monomer (VCM) plants, and Hoechst's Kalle PVC film business, have been left out. Erich Schnitzler, head of Hoechst's PVC business unit, does not anticipate problems with the European Community's competition directorate. We are both among the middle-sized European PVC producers, and together we would have a 9%-10% market share. Our jointmore » venture would not limit competition. Both partners are hoping for approval from Brussels in first-quarter 1993. Hoechst has 255,000 m.t./year of PVC capacity at Gendorfand Knapsack, while Wacker has 365,000 m.t./year at Burghausen and Cologne. All the units, except Wacker's Cologne plant, are back integrated to VCM. The joint venture would buy VCM from the two parent companies and on the merchant market.« less

The costs and benefits of a cigarette ban.

PubMed

Doucet, Mathieu

2017-06-01

The death toll from tobacco is staggering: it might contribute to one billion premature deaths over the course of the 21st century. In 'The case for banning cigarettes', Kalle Grill and Kristin Voigt argue that the well-being and equality benefits of a complete ban on cigarettes more than justify the restrictions on autonomy that such a ban would impose. Their argument depends on two crucial simplifications: an assumption that the ban would be effective and the restriction of the analysis to a comparison with the status quo, rather than a broader range of policy options. I argue that despite the authors' claims, these two simplifications make it impossible for their argument to 'bring into focus the fundamental normative issues' surrounding a possible cigarette ban, since they dramatically overstate the benefits and obscure the most significant costs of such a ban. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Overweight, obesity and related conditions: a cross-sectional study of adult inpatients at a Norwegian Hospital

PubMed Central

2014-01-01

Background Overweight, obesity and associated conditions are major public health concerns in Norway. The prevalence of overweight and obesity in the general population in Norway is increasing, but there are limited data on how the situation is in hospitals. This study aimed to find the prevalence of overweight and obesity, and explore the associations of overweight, obesity and its related medical conditions in an adult in-patient sample at specified somatic and psychiatric departments at St. Olavs Hospital, Trondheim. Results A total of 497 patients participated. The mean BMI for the total sample at screening was 25.4 kg/m2. The prevalence of overweight and obesity was 45.1%. There was a higher association of overweight and obesity among patients aged 40–59 years (OR: 1.7) compared to those being younger. There was no significant difference between the somatic and the psychiatric samples. In the somatic sample overweight and obesity was associated with obesity-related conditions for both genders (OR: 2.0 and 2.1, respectively), when adjusted for age. Conclusion The substantial prevalence of overweight and obese patients may pose a threat to future hospital services. To further address the burden of overweight and obesity in hospitals, we need more knowledge about consequences of length of stay, use of resources and overall cost. PMID:24571809

Do surgeons and surgical facilities disturb the clean air distribution close to a surgical patient in an orthopedic operating room with laminar airflow?

PubMed

Cao, Guangyu; Storås, Madeleine C A; Aganovic, Amar; Stenstad, Liv-Inger; Skogås, Jan Gunnar

2018-05-04

Airflow distribution in the operating room plays an important role in ensuring a clean operating microenvironment and preventing surgical site infections (SSIs) caused by airborne contaminations. The objective of this study was to characterize the airflow distribution in proximity to a patient in an orthopedic operating room. Experimental measurements were conducted in a real operating room at St. Olav's Hospital, Norway, with a laminar airflow system. Omnidirectional anemometers were used to investigate the air distribution in the operating zone, and 4 different cases were examined with a real person and a thermal manikin. This study showed that the downward airflow from the laminar airflow system varies in each case with different surgical arrangement, such as the position of the operating lamp. The results indicate that the interaction of thermal plumes from a patient and the downward laminar airflow may dominate the operating microenvironment. The airflow distribution in proximity to a patient is influenced by both the surgical facility and the presence of medical staff. A thermal manikin may be an economical and practical way to study the interaction of thermal plumes and downward laminar airflow. The provision of higher clean airflow rate in the operating microenvironment may be an effective way to prevent the development of SSIs caused by indoor airborne contamination. Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

The effect from maximal bench press strength training on work economy during wheelchair propulsion in men with spinal cord injury.

PubMed

Tørhaug, T; Brurok, B; Hoff, J; Helgerud, J; Leivseth, G

2016-10-01

To assess the effect from maximal bench press strength training (MST) on wheelchair propulsion work economy (WE). Pretest-posttest case-control group design. St Olavs Hospital, Trondheim, Norway. Seventeen male individuals with spinal cord injury (SCI) paraplegia were allocated to either MST bench press (n=11) or the control group (CG) (n=7). The MST group trained bench press three times per week, for 6 weeks, starting at 85-95% of their pretest bench press one-repetition maximum (1RM). For calculation of WE during wheelchair propulsion, oxygen uptake (VO 2 ) measurements were collected during wheelchair ergometry (WCE) at submaximal workload of 50 W. Similarly, peak oxygen uptake (VO 2peak ) and peak power output (W) were measured during WCE. Individuals in the MST regimen significantly improved WE compared with the CG by 17.3 % (mean between-group differences: 95% confidence interval) of 2.63 ml kg -1  min -1 : (-4.34, -0.91) (P=0.007). Between pretest and posttest, the increase in bench press 1RM was by 17% higher in the MST group compared with the CG. At peak testing, the MST group generated significantly higher peak power compared with the CG. All other physiological variables were comparable within and between groups. A 6-week MST bench press regimen significantly improved WE during wheelchair propulsion at 50 W workload. These preliminary data support a possible beneficial role for MST to reduce the energy cost of wheelchair propulsion for SCI individuals.

Quality of life in children and adolescents surviving cancer.

PubMed

Bradley Eilertsen, Mary-Elizabeth; Jozefiak, Thomas; Rannestad, Toril; Indredavik, Marit S; Vik, Torstein

2012-04-01

To explore subjective and proxy reported QoL (Quality of Life) in children and adolescents surviving cancer three years after diagnosis compared with healthy controls. Case-control study including 50 children and adolescents diagnosed with cancer between January 1, 1993 and January 1, 2003 and treated at the Paediatric Department of St. Olav's University Hospital in Trondheim, Norway. Data were collected using The Inventory of Life Quality in Children and Adolescents (ILC) and the KINDL QoL questionnaires (parent and self-reports), as well as by collecting data for any somatic late effects and psychological problems from the medical records of children surviving cancer. Adolescents surviving cancer as a group assessed their QoL as similar to that of their peers. However, adolescents surviving brain tumours or those with late effects reported lower QoL and an increased number of QoL domains perceived as problematic, even many years after diagnosis and treatment. Parents generally report a poorer QoL for their children surviving cancer and a greater number of QoL domains experienced as problematic compared with parent controls. To improve the child's total functioning and well-being we conclude that when planning long-term follow-up care, rehabilitation of children and adolescents with cancer, especially for survivors with brain tumours, and with late effects should particularly take into account their subjectively perceived and proxy reported QoL, in addition to their psychological problems and psychosocial functioning. Copyright © 2011 Elsevier Ltd. All rights reserved.

The Value of Visa-Score and Colour Flow Imaging in the Follow-Up of Non-Athletes Operated for Jumpers Knee.

PubMed

Salvesen, Eirik S; Holen, Ketil J

2016-12-01

The objective of this study was to assess if the Victorian Institute of Sport Assessment (VISA) questionnaire was suitable in the evaluation of patients from a mixed population with normal levels of sports activity, and if neovascularization of the patellar tendon demonstrated by color flow imaging (CFI) was more frequent in patients with lasting symptoms after surgical treatment for jumpers knee (JK). This study was conducted at St. Olavs Hospital, University Hospital of Trondheim, Norway, and included 21 men and 18 women who were operated for JK. Symptoms were assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and VISA questionnaires. Clinical and ultrasonographic examinations of the knees, including CFI, were done at a mean follow-up duration of 82 (range, 16-136) months after surgery. Patients with positive CFI also had significantly lower KOOS scores, whereas the total VISA-P (Victorian Institute of Sport Assessment - Patella) score showed no association. Patients with a positive clinical examination had significantly more frequent positive CFI findings than did patients with negative examinations. The operated patellar tendon was significantly thicker and had more frequent hypoechoic signal in the proximal part than the contralateral unoperated tendon. The post-operative VISA-P score seems less valuable in the evaluation of patients from a mixed population with normal levels of sports activity. CFI may be a valuable diagnostic tool in the evaluation of patients operated for JK.

Does regular exercise including pelvic floor muscle training prevent urinary and anal incontinence during pregnancy? A randomised controlled trial.

PubMed

Stafne, S N; Salvesen, K Å; Romundstad, P R; Torjusen, I H; Mørkved, S

2012-09-01

To assess whether pregnant women following a general exercise course, including pelvic floor muscle training (PFMT), were less likely to report urinary and anal incontinence in late pregnancy than a group of women receiving standard care. A two-armed, two-centred randomised controlled trial. Trondheim University Hospital (St. Olavs Hospital) and Stavanger University Hospital, in Norway. A total of 855 women were included in this trial. The intervention was a 12-week exercise programme, including PFMT, conducted between 20 and 36 weeks of gestation. One weekly group session was led by physiotherapists, and home exercises were encouraged at least twice a week. Controls received regular antenatal care. Self-reported urinary and anal incontinence after the intervention period (at 32-36 weeks of gestation). Fewer women in the intervention group reported any weekly urinary incontinence (11 versus 19%, P = 0.004). Fewer women in the intervention group reported faecal incontinence (3 versus 5%), but this difference was not statistically significant (P = 0.18). The present trial indicates that pregnant women should exercise, and in particular do PFMT, to prevent and treat urinary incontinence in late pregnancy. Thorough instruction is important, and specific pelvic floor muscle exercises should be included in exercise classes for pregnant women. The preventive effect of PFMT on anal incontinence should be explored in future trials. © 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.

Lack of patients? A hypothesis for understanding discrepancies between hospital resources and productivity.

PubMed

Bratlid, Dag

2006-04-02

Despite a substantial increase in hospital resources, increased hospital admissions and out-patient visits, long waiting lists have been a significant problem in Norwegian health care. A detailed analysis of the development in resource allocation and productivity at St. Olavs University Hospital in central Norway was therefore undertaken. Resource allocation and patient volume was analysed during the period 1995 to 2001. Data were analysed both for emergency and elective admissions as well as outpatient visits specified into new referrals and follow-up consultations. Full time employee equivalents for doctors and nurses increased by 36.6% and 25.9%, respectively, and all employees by 28.1%. However, admitted patients, outpatient consultations and surgical procedures only increased by 10%, 15% and 8.3%, respectively. Thus, the productivity for each hospital employee, defined as operations pr. surgeon, outpatient consultations pr. doctor etc. was significantly reduced. A striking finding was that although the number of outpatient consultations increased, the number of new referrals actually went down and the whole increase in activity at the outpatient clinics could be explained by a substantial increase in follow-up consultations. This trend was more evident in the surgical departments, where some departments actually showed a reduction in total outpatient consultations. In view of the slow increase in hospital activity in spite of a significant increase in resources, it can be speculated that patient volume might be a limiting factor for hospital activity. The health market (patient population) might not be big enough in relation to the investments in increased production capacity (equipment and manpower).

Lack of patients? – a hypothesis for understanding discrepancies between hospital resources and productivity

PubMed Central

Bratlid, Dag

2006-01-01

Background Despite a substantial increase in hospital resources, increased hospital admissions and out-patient visits, long waiting lists have been a significant problem in Norwegian health care. A detailed analysis of the development in resource allocation and productivity at St. Olavs University Hospital in central Norway was therefore undertaken. Methods Resource allocation and patient volume was analysed during the period 1995 to 2001. Data were analysed both for emergency and elective admissions as well as outpatient visits specified into new referrals and follow-up consultations. Results Full time employee equivalents for doctors and nurses increased by 36.6% and 25.9%, respectively, and all employees by 28.1%. However, admitted patients, outpatient consultations and surgical procedures only increased by 10%, 15% and 8.3%, respectively. Thus, the productivity for each hospital employee, defined as operations pr. surgeon, outpatient consultations pr. doctor etc. was significantly reduced. A striking finding was that although the number of outpatient consultations increased, the number of new referrals actually went down and the whole increase in activity at the outpatient clinics could be explained by a substantial increase in follow-up consultations. This trend was more evident in the surgical departments, where some departments actually showed a reduction in total outpatient consultations. Conclusion In view of the slow increase in hospital activity in spite of a significant increase in resources, it can be speculated that patient volume might be a limiting factor for hospital activity. The health market (patient population) might not be big enough in relation to the investments in increased production capacity (equipment and manpower). PMID:16579861

Spinal cord injuries among paragliders in Norway.

PubMed

Rekand, T; Schaanning, E E; Varga, V; Schattel, U; Gronning, M

2008-06-01

A national retrospective descriptive study. To study the clinical effects of spinal cord injuries (SCIs) caused by paragliding accidents in Norway. Spinal cord units at Haukeland University Hospital, Sunnaas Rehabilitation Hospital and St Olav Hospital in Norway. We studied the medical files for nine patients with SCI caused by paragliding accidents to evaluate the circumstances of the accidents, and clinical effects of injury. We obtained the data from hospital patient files at all three spinal units in Norway and crosschecked them through the Norwegian Paragliding Association's voluntary registry for injuries. All patients were hospitalized from 1997 to 2006, eight men and one woman, with mean age 30.7 years. The causes of the accidents were landing problems combined with unexpected wind whirls, technical problems and limited experience with unexpected events. All patients contracted fractures in the thoracolumbal junction of the spine, most commonly at the L1 level. At clinical follow-up, all patients presented clinically incomplete SCI (American Spinal Injury Association impairment scores B-D). Their main health problems differed widely, ranging from urinary and sexual disturbances to neuropathic pain and loss of motor functioning. Only three patients returned to full-time employment after rehabilitation. Paragliding accidents cause spinal fractures predominantly in the thoracolumbal junction with subsequent SCIs and increased morbidity. All patients experienced permanent health problems that influenced daily activities and required long-time clinical follow-up and medical intervention. Better education in landing techniques and understanding of aerodynamics may reduce the risk of paragliding accidents.

'I want a choice, but I don't want to decide'--a qualitative study of pregnant women's experiences regarding early ultrasound risk assessment for chromosomal anomalies.

PubMed

Aune, Ingvild; Möller, Anders

2012-02-01

To increase our understanding of how pregnant women experience early ultrasound examination that includes a risk assessment for chromosomal anomalies and how such women perceive the test results. Qualitative study at St. Olavs Hospital in Norway. Both pre- and post-examination interviews were conducted with ten pregnant women who underwent risk assessment for chromosomal anomalies. Grounded theory was used to analyse the results. The study generated a core category (I want a choice, but I don't want to decide), which related to the conflict between choice and decision making. There were also five main categories (existential choices, search for knowledge, anxiety, feeling of guilt and counselling and care). The main categories describe the complex feelings experienced by the women regarding the risk assessment. Factors contributing to the difficulty of choice included loss of control and coping, emotional connection to the fetus and social pressure. As the women sought independent choices without any external influence, they also felt greater responsibility. The women's understanding of the actual risk varied, and they used different types of logic and methods to evaluate the risk and reach a decision. The pregnant women in this study wanted prenatal diagnostic information and easy access to specialty services. Stress-related feelings and non-transparent information about the actual and perceived risks as well as personal moral judgments made the decision-making process complicated. Improved distribution of information and frequent contact with health professionals may help such women to make informed choices in accordance with their values and beliefs. Copyright © 2010 Elsevier Ltd. All rights reserved.

Psychosocial Vulnerability Among Patients Contacting a Norwegian Sexual Assault Center.

PubMed

Vik, Bjarte Frode; Nöttestad, Jim Aage; Schei, Berit; Rasmussen, Kirsten; Hagemann, Cecilie Therese

2016-07-01

In this study, the objective was to assess the occurrence of specific vulnerability factors among adult and adolescent females attending a Norwegian sexual assault center (SAC). We also explored assault characteristics and investigated whether these characteristics differed between the group of patients with vulnerability factors compared with the group without such factors. We conducted a retrospective descriptive study of 573 women ≥ 12 years of age attending the SAC at St. Olavs Hospital, Trondheim, Norway, between July 1, 2003 and December 31, 2010. A patient was considered vulnerable if at least one of the following features was present: intellectual or physical disability; history of present/former mental health problems; history of present/former alcohol/substance abuse; or former sexual assault. At least one vulnerability factor was present in 59% of the cases. More than one vulnerability factor was present in 29%. Reporting at least one vulnerability factor was associated with a higher patient age, unemployment, a higher frequency of reported light/moderate physical violence, and the documentation of minor body injury. In contrast, those without vulnerability more often were students assaulted during night time, by a casual or stranger assailant and reporting a higher intake of alcohol prior to the assault. There are obvious patterns of differences in the nature of sexual assaults reported among victims with specific vulnerability factors compared with victims without these factors. Future research should address these differences and possible solutions for better protection of especially vulnerable individuals against sexual offenses, such as those with mental health and substance abuse difficulties.

Assessment of the time-dependent need for stay in a high dependency unit (HDU) after major surgery by using data from an anesthesia information management system.

PubMed

Betten, Jan; Roness, Aleksander Kirkerud; Endreseth, Birger Henning; Trønnes, Håkon; Tyvold, Stig Sverre; Klepstad, Pål; Nordseth, Trond

2016-04-01

Admittance to a high dependency unit (HDU) is expensive. Patients who receive surgical treatment with 'low anterior resection of the rectum' (LAR) or 'abdominoperineal resection of the rectum' (APR) at our hospital are routinely treated in an HDU the first 16-24 h of the postoperative (PO) period. The aim of this study was to describe the extent of HDU-specific interventions given. We included patients treated with LAR or APR at the St. Olav University Hospital (Trondheim, Norway) over a 1-year period. Physiologic data and HDU-interventions recorded during the PO-period were obtained from the anesthesia information management system (AIMS). HDU-specific interventions were defined as the need for respiratory support, fluid replacement therapy >500 ml/h, vasoactive medications, or a need for high dose opioids (morphine >7.5 mg/h i.v.). Sixty-two patients were included. Most patients needed HDU-specific interventions during the first 6 h of the PO period. After this, one-third of the patients needed one or more of the HDU-specific interventions for shorter periods of time. Another one-third of the patients had a need for HDU-specific therapies for more than ten consecutive hours, primarily an infusion of nor-epinephrine. Most patients treated with LAR or APR was in need of an HDU-specific intervention during the first 6 h of the PO-period, with a marked decline after this time period. The applied methodology, using an AIMS, demonstrates that there is great variability in individual patients' postoperative needs after major surgery, and that these needs are dynamic in their nature.

Outcome in adolescence of brachial plexus birth palsy. 69 individuals re-examined after 10–20 years.

PubMed

Hulleberg, Gunn; Elvrum, Ann-Kristin G; Brandal, Merethe; Vik, Torstein

2014-12-01

The frequency and severity of a permanent lesion after brachial plexus birth palsy (BPBP) and its impact on activities of daily living are not well documented. We therefore investigated the outcome of BPBP in adolescents, regarding arm function and consequences for activity and participation. Of 30,574 babies born at St. Olavs University Hospital in 1991-2000, 91 had BPBP (prevalence 3 per 1,000), and 69 of these individuals were examined at a median age of 14 (10-20) years. The examination included the modified Mallet classification, range of motion, shoulder rotation and grip strength, Assisting Hand Assessment, and Canadian Occupational Performance Measure. Of the 22 subjects who were not examined, 3 could not be traced and 19 reported having no problems in the affected arm. At follow-up, 17 adolescents had a permanent lesion (i.e. individual Mallet subscore below 4) with a median Mallet total score of 15 (9-19), while 52 had good or normal shoulder function (median Mallet total score 25 (23-25)). All participants with a permanent lesion had reduced active shoulder rotation (≤15°), 16 had elbow extension deficit, and 10 had subnormal grip strength. External rotation was considerably weaker in the affected shoulder. In addition, they had ineffective use of the affected arm in bimanual activities. Even so, all except 1 were independent in activities of daily living, although 15 experienced minor difficulties. Every fourth to fifth child with BPBP had a permanent lesion as an adolescent. External rotation was the most impaired movement. Despite ineffective use of the affected arm in bimanual activities, all of the participants except one were independent in activities of daily living.

Effect of in-hospital comprehensive geriatric assessment (CGA) in older people with hip fracture. The protocol of the Trondheim Hip Fracture Trial

PubMed Central

2011-01-01

Background Hip fractures in older people are associated with high morbidity, mortality, disability and reduction in quality of life. Traditionally people with hip fracture are cared for in orthopaedic departments without additional geriatric assessment. However, studies of postoperative rehabilitation indicate improved efficiency of multidisciplinary geriatric rehabilitation as compared to traditional care. This randomized controlled trial (RCT) aims to investigate whether an additional comprehensive geriatric assessment of hip fracture patients in a special orthogeriatric unit during the acute in-hospital phase may improve outcomes as compared to treatment as usual in an orthopaedic unit. Methods/design The intervention of interest, a comprehensive geriatric assessment is compared with traditional care in an orthopaedic ward. The study includes 401 home-dwelling older persons >70 years of age, previously able to walk 10 meters and now treated for hip fracture at St. Olav Hospital, Trondheim, Norway. The participants are enrolled and randomised during the stay in the Emergency Department. Primary outcome measure is mobility measured by the Short Physical Performance Battery (SPPB) at 4 months after surgery. Secondary outcomes measured at 1, 4 and 12 months postoperatively are place of residence, activities of daily living, balance and gait, falls and fear of falling, quality of life and depressive symptoms, as well as use of health care resources and survival. Discussion We believe that the design of the study, the randomisation procedure and outcome measurements will be of sufficient strength and quality to evaluate the impact of comprehensive geriatric assessment on mobility and other relevant outcomes in hip fracture patients. Trials registration ClinicalTrials.gov, NCT00667914 PMID:21510886

Impact of medico-legal findings on charge filing in cases of rape in adult women.

PubMed

Hagemann, Cecilie T; Stene, Lise E; Myhre, Arne K; Ormstad, Kari; Schei, Berit

2011-11-01

To assess the impact of the medical documentation and biological trace evidence in rape cases on the legal process. Retrospective descriptive study. Police-reported cases of rape of women ≥16 years old in the Norwegian county of Sør-Trøndelag from January 1997 to June 2003. Police data were merged with data from the Sexual Assault Center at St Olav's Hospital. Charged and non-charged cases were compared. Medico-legal findings and legal outcome. A total of 185 police-reported cases were identified. Of the 101 cases examined at Sexual Assault Center, charges were filed in 18 cases. Extragenital injuries were documented in 49 women; five were life threatening. Anogenital injuries were documented in 14 women; eight had multiple anogenital injuries. Documentation of injuries was not associated with charge filing. In only 33% of the cases were swabs collected from women's genitals used as trace evidence by the police. When used, this increased the likelihood for charge filing. A DNA profile matching the suspect was identified in four of the 18 charged cases and in only one among the 54 non-charged cases. Half of the women had one or more documented injury. Only one-third of the trace evidence kits collected from the women's anogenital area were analyzed. The analysis of swabs was associated with charge filing, regardless of test results. Increased use of such medical evidence, especially in cases of stranger rape, may ensure women's rights and increase available information to the legal system. © 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.

Outcome in adolescence of brachial plexus birth palsy

PubMed Central

Hulleberg, Gunn; Elvrum, Ann-Kristin G; Brandal, Merethe; Vik, Torstein

2014-01-01

Background and purpose — The frequency and severity of a permanent lesion after brachial plexus birth palsy (BPBP) and its impact on activities of daily living are not well documented. We therefore investigated the outcome of BPBP in adolescents, regarding arm function and consequences for activity and participation. Participants and methods — Of 30,574 babies born at St. Olavs University Hospital in 1991–2000, 91 had BPBP (prevalence 3 per 1,000), and 69 of these individuals were examined at a median age of 14 (10–20) years. The examination included the modified Mallet classification, range of motion, shoulder rotation and grip strength, Assisting Hand Assessment, and Canadian Occupational Performance Measure. Of the 22 subjects who were not examined, 3 could not be traced and 19 reported having no problems in the affected arm. Results — At follow-up, 17 adolescents had a permanent lesion (i.e. individual Mallet subscore below 4) with a median Mallet total score of 15 (9–19), while 52 had good or normal shoulder function (median Mallet total score 25 (23–25)). All participants with a permanent lesion had reduced active shoulder rotation (≤ 15°), 16 had elbow extension deficit, and 10 had subnormal grip strength. External rotation was considerably weaker in the affected shoulder. In addition, they had ineffective use of the affected arm in bimanual activities. Even so, all except 1 were independent in activities of daily living, although 15 experienced minor difficulties. Interpretation — Every fourth to fifth child with BPBP had a permanent lesion as an adolescent. External rotation was the most impaired movement. Despite ineffective use of the affected arm in bimanual activities, all of the participants except one were independent in activities of daily living. PMID:25238434

Interview: Cancer pain management: the last decade and looking forward.

PubMed

Kaasa, Stein

2013-11-01

Stein Kaasa, MD, speaks to Dominic Chamberlain, Assistant Commissioning Editor: Stein Kaasa specializes in oncology and palliative medicine. In 1993 he was appointed as the first professor in palliative medicine in Scandinavia and he was one of the founders of the palliative care unit in Trondheim (Norway). He also was the founder of the European Palliative Care Research Centre. He has been president of the European Association for Palliative Care, coordinator for one EU-funded project and is Work Package Leader of several EU-funded research collaboratives and international partnerships on research and policy development. Kaasa has been an important advocate for evidence-based practice and has worked extensively to get palliative care research on the agenda, both nationally and internationally. Through his role as Cancer Director in Norway he coordinated and led the development of guidelines for different cancer diseases. Important areas of work were the development of regional cancer treatment guidelines and integration of patient disease trajectories into the existing guidelines. Currently he is Vice Managing Director at St Olavs Hospital, Trondheim University Hospital (Norway), Professor of palliative medicine at the Faculty of Medicine, Norwegian University of Science and Technology and leads the European Palliative Care Research Centre and chairs the European Association for Palliative Care Research Network. Professor Kaasa has published more than 450 articles and book chapters. He has authored the Nordic Textbook of Palliative Care and is coauthor and editor of the Oxford Textbook of Palliative Medicine. Professor Kaasa advises many international journals - either as an advisory board member or as a reviewer (Journal of Pain and Symptom Management, Palliative Medicine, Journal of Palliative Medicine, Oncology, Journal of Clinical Oncology, Pain and The Lancet Oncology).

[Childhood bacterial meningitis in the Norwegian county Sør-Trøndelag 1988 - 2007].

PubMed

Skoe, Øyvind; Døllner, Henrik

2009-04-30

Bacterial meningitis is a severe and feared disease. We have studied bacterial meningitis in children in Sør-Trøndelag county during a 20-year period from 1988 to 2008. Medical records of children (in-patients) with spinal fluid findings or a clinical diagnosis of bacterial meningitis, at St. Olavs Hospital, were retrospectively reviewed. 112 cases of bacterial meningitis were registered in children below 16 years of age in Sør-Trøndelag county between 1988 and 2008. Children younger than 2 years had the highest occurrence, with a mean annual incidence of 42.3 per 100,000, whereas the incidence among children in the age group 2 to 16 was 5.7 per 100,000. We observed a decline in the occurrence from 19.1 per 100,000 in the period 1988 - 1991, to 6.9 per 100,000 in the period 2003 - 2006. 31 cases of Haemophilus influenzae type B, 26 cases of Neisseria meningitidis group B, 26 of Streptococcus pneumoniae and 19 cases with other pathogens were registered. The occurrence of H influenzae and N meningitidis have declined over the entire period, whereas S pneumoniae has increased. 6/112 children died (5.4 %) and 34 developed sequelae (30.4 %). In a multiple logistic regression analysis, the maximal value of C-reactive protein was associated with an increased risk of developing sequelae, adjusted for age and triggering microbe. The incidence of bacterial meningitis among children in Sør-Trøndelag has decreased significantly over the last 20 years, and meningitis is now a rare disease. Bacterial meningitis is most common among children below the age of two, and is still associated with a substantial mortality and risk of long-term neurological sequalae.

Correlation between prenatal ultrasound and postmortem findings in 1029 fetuses following termination of pregnancy.

PubMed

Struksnaes, C; Blaas, H-G K; Eik-Nes, S H; Vogt, C

2016-08-01

A prenatal ultrasound examination and a postmortem examination provide the basis for correct diagnosis in fetuses terminated due to congenital anomalies. The aim of this study was to correlate fetal anomalies detected by ultrasound examination with those identified at autopsy following termination of pregnancy (TOP) over a 30-year period, and to evaluate the correlation between findings at different gestational ages and assess these trends over time. The study group consisted of 1029 TOPs performed over a 30-year period, from 1985 to 2014. The gestational age ranged between 11 and 33 weeks. Prenatal ultrasound examinations were performed at the National Center for Fetal Medicine, St Olavs Hospital, Trondheim, Norway. Autopsies were performed at the Department of Pathology and Medical Genetics at the same hospital or a collaborating hospital. There was full agreement between ultrasound and autopsy findings in 88.1% (907/1029) of TOPs, and the main diagnosis was correct in 97.9% (1007/1029). When comparing the 15-year period of 2000-2014 with that of 1985-1999, the difference in the rates of full agreement and agreement in the main diagnosis was statistically significant. In 1.3% (13/1029) of cases, ultrasound findings were not confirmed at autopsy. There were no false-positive diagnoses leading to TOP. Throughout the 30-year period, there was an increase in early TOPs, whereas late TOPs declined. Our study demonstrates that there is a clear correlation between ultrasound and autopsy findings, which is continuously improving. Despite this high correlation, there is reason to continue the practice of validation to ensure the safety of the diagnostic process leading to TOP. The trend towards an earlier termination emphasizes the necessity of such a practice. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.

The microINR portable coagulometer: analytical quality and user-friendliness of a PT (INR) point-of-care instrument.

PubMed

Larsen, Pia Bükmann; Storjord, Elin; Bakke, Åsne; Bukve, Tone; Christensen, Mikael; Eikeland, Joakim; Haugen, Vegar Engeland; Husby, Kristin; McGrail, Rie; Mikaelsen, Solveig Meier; Monsen, Grete; Møller, Mette Fogh; Nybo, Jan; Revsholm, Jesper; Risøy, Aslaug Johanne; Skålsvik, Unni Marie; Strand, Heidi; Teruel, Reyes Serrano; Theodorsson, Elvar

2017-04-01

Regular measurement of prothrombin time as an international normalized ratio PT (INR) is mandatory for optimal and safe use of warfarin. Scandinavian evaluation of laboratory equipment for primary health care (SKUP) evaluated the microINR portable coagulometer (microINR ® ) (iLine Microsystems S.L., Spain) for measurement of PT (INR). Analytical quality and user-friendliness were evaluated under optimal conditions at an accredited hospital laboratory and at two primary health care centres (PHCCs). Patients were recruited at the outpatient clinic of the Laboratory of Medical Biochemistry, St Olav's University Hospital, Trondheim, Norway (n = 98) and from two PHCCs (n = 88). Venous blood samples were analyzed under optimal conditions on the STA-R ® Evolution with STA-SPA + reagent (Stago, France) (Owren method), and the results were compared to capillary measurements on the microINR ® . The imprecision of the microINR ® was 6% (90% CI: 5.3-7.0%) and 6.3% (90% CI: 5.1-8.3) in the outpatient clinic and PHCC2, respectively for INR ≥2.5. The microINR ® did not meet the SKUP quality requirement for imprecision ≤5.0%. For INR <2.5 at PHCC2 and at both levels in PHCC1, CV% was ≤5.0. The accuracy fulfilled the SKUP quality goal in both outpatient clinic and PHCCs. User-friendliness of the operation manual was rated as intermediate, defined by SKUP as neutral ratings assessed as neither good nor bad. Operation facilities was rated unsatisfactory, and time factors satisfactory. In conclusion, quality requirements for imprecision were not met. The SKUP criteria for accuracy was fulfilled both at the hospital and at the PHCCs. The user-friendliness was rated intermediate.

Failed pelvic pouch substituted by continent ileostomy.

PubMed

Wasmuth, H H; Tranø, G; Wibe, A; Endreseth, B H; Rydning, A; Myrvold, H E

2010-07-01

The long-term failure rate of ileal pouch-anal anastomosis (IPAA) is 10-15%. When salvage surgery is unsuccessful, most surgeons prefer pouch excision with conventional ileostomy, thus sacrificing 40-50 cm of ileum. Conversion of a pelvic pouch to a continent ileostomy (CI, Kock pouch) is an alternative that preserves both the ileal surface and pouch properties. The aim of the study was to evaluate clinical outcome after the construction of a CI following a failed IPAA. During 1984-2007, 317 patients were operated with IPAA at St Olavs Hospital and evaluated for failure, treatment and outcome. Seven patients with IPAA failure had CI. Four patients with IPAA failure referred from other hospitals underwent conversion to CI and are included in the final analysis. Seven patients had a CI constructed from the transposing pelvic pouch and four had the pelvic pouch removed and a new continent pouch constructed from the distal ileum. Median follow up after conversion to CI was 7 years (0-17 years). Two CI had to be removed due to fistulae. One patient needed a revision of the nipple valve due to pouch loosening. At the end of follow-up, 8 of the 11 patients were fully continent. One patient with Crohn's disease had minor leakage. In patients with pelvic pouch failure, the possibility of conversion to CI should be presented to the patient as an alternative to pouch excision and permanent ileostomy. The advantage is the continence and possibly a better body image. Construction of a CI on a new ileal segment may be considered, but the consequences of additional small bowel loss and risk of malnutrition if the Kock pouch fails should be appraised.

Uncertainty estimation of predictions of peptides' chromatographic retention times in shotgun proteomics.

PubMed

Maboudi Afkham, Heydar; Qiu, Xuanbin; The, Matthew; Käll, Lukas

2017-02-15

Liquid chromatography is frequently used as a means to reduce the complexity of peptide-mixtures in shotgun proteomics. For such systems, the time when a peptide is released from a chromatography column and registered in the mass spectrometer is referred to as the peptide's retention time . Using heuristics or machine learning techniques, previous studies have demonstrated that it is possible to predict the retention time of a peptide from its amino acid sequence. In this paper, we are applying Gaussian Process Regression to the feature representation of a previously described predictor E lude . Using this framework, we demonstrate that it is possible to estimate the uncertainty of the prediction made by the model. Here we show how this uncertainty relates to the actual error of the prediction. In our experiments, we observe a strong correlation between the estimated uncertainty provided by Gaussian Process Regression and the actual prediction error. This relation provides us with new means for assessment of the predictions. We demonstrate how a subset of the peptides can be selected with lower prediction error compared to the whole set. We also demonstrate how such predicted standard deviations can be used for designing adaptive windowing strategies. lukas.kall@scilifelab.se. Our software and the data used in our experiments is publicly available and can be downloaded from https://github.com/statisticalbiotechnology/GPTime . © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Complex Systems: Control and Modeling Problems

DTIC Science & Technology

2004-08-23

von Mat- thias Kalle Dalheimer. - 4. Aufl.. - Beijing ; Koln : O’Reilly, 2003. - XVII, 1084 S.; (dt.) ISBN 3-89721- 332-X Original: Java in a...Берлин: Техник, 1988. [7] Форрестер Д. Основы кибернетики предприятия (индустриальная динамика): Пер. с англ. – М.: Про- гресс, 1971 . 385...размерности системы уравнений для синтеза оптимального управления. Оптимальные и самонастраивающиеся системы. – Новосибирск: Изд. ИАиЭ АН СССР, 1971

Spectrofluorimetric determination of melatonin in kernels of four different Pistacia varieties after ultrasound-assisted solid-liquid extraction.

PubMed

Oladi, Elham; Mohamadi, Maryam; Shamspur, Tayebeh; Mostafavi, Ali

2014-11-11

Melatonin is normally consumed to regulate the body's biological cycle. However it also has therapeutic properties, such as anti-tumor, anti-aging and protects the immune system. There are some reports on the presence of melatonin in edible kernels such as walnuts, but the extraction of melatonin from pistachio kernels is reported here for the first time. For this, the methanolic extract of pistachio kernels was exposed to gas chromatography/mass spectrometry analysis which confirmed the presence of melatonin. A fluorescence-based method was applied for the determination of melatonin in different extracts. When excited at λ=275 nm, the fluorescence emission intensity of melatonin was measured at λ=366 nm. Ultrasound-assisted solid-liquid extraction was used for the extraction of melatonin from pistachio kernels prior to fluorimetric determination. To achieve the highest extraction recovery, the main parameters affecting the extraction efficiency such as extracting solvent type and volume, temperature, sonication time and pH were evaluated. Under the optimized conditions, a linear dependence of fluorescence intensity on melatonin concentration was observed in the range of 0.0040-0.160 μg mL(-1), with a detection limit of 0.0036 μg mL(-1). This method was applied successfully for measuring and comparing the melatonin content in the kernels of four different varieties of Pistacia including Ahmad Aghaei, Akbari, Kalle Qouchi and Fandoghi. In addition, the results obtained were compared with those obtained using GC/MS. A good agreement was observed indicating the reliability of the proposed method. Copyright © 2014 Elsevier B.V. All rights reserved.

Spectrofluorimetric determination of melatonin in kernels of four different Pistacia varieties after ultrasound-assisted solid-liquid extraction

NASA Astrophysics Data System (ADS)

Oladi, Elham; Mohamadi, Maryam; Shamspur, Tayebeh; Mostafavi, Ali

2014-11-01

Melatonin is normally consumed to regulate the body's biological cycle. However it also has therapeutic properties, such as anti-tumor, anti-aging and protects the immune system. There are some reports on the presence of melatonin in edible kernels such as walnuts, but the extraction of melatonin from pistachio kernels is reported here for the first time. For this, the methanolic extract of pistachio kernels was exposed to gas chromatography/mass spectrometry analysis which confirmed the presence of melatonin. A fluorescence-based method was applied for the determination of melatonin in different extracts. When excited at λ = 275 nm, the fluorescence emission intensity of melatonin was measured at λ = 366 nm. Ultrasound-assisted solid-liquid extraction was used for the extraction of melatonin from pistachio kernels prior to fluorimetric determination. To achieve the highest extraction recovery, the main parameters affecting the extraction efficiency such as extracting solvent type and volume, temperature, sonication time and pH were evaluated. Under the optimized conditions, a linear dependence of fluorescence intensity on melatonin concentration was observed in the range of 0.0040-0.160 μg mL-1, with a detection limit of 0.0036 μg mL-1. This method was applied successfully for measuring and comparing the melatonin content in the kernels of four different varieties of Pistacia including Ahmad Aghaei, Akbari, Kalle Qouchi and Fandoghi. In addition, the results obtained were compared with those obtained using GC/MS. A good agreement was observed indicating the reliability of the proposed method.

Development of a Tailored Intervention With Computerized Clinical Decision Support to Improve Quality of Care for Patients With Knee Osteoarthritis: Multi-Method Study.

PubMed

Van de Velde, Stijn; Kortteisto, Tiina; Spitaels, David; Jamtvedt, Gro; Roshanov, Pavel; Kunnamo, Ilkka; Aertgeerts, Bert; Vandvik, Per Olav; Flottorp, Signe

2018-06-11

complexity, and (3) maintain user engagement with CDS over time. ©Stijn Van de Velde, Tiina Kortteisto, David Spitaels, Gro Jamtvedt, Pavel Roshanov, Ilkka Kunnamo, Bert Aertgeerts, Per Olav Vandvik, Signe Flottorp. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 11.06.2018.

Teaching and learning science in linguistically diverse classrooms

NASA Astrophysics Data System (ADS)

Moore, Emilee; Evnitskaya, Natalia; Ramos-de Robles, S. Lizette

2017-01-01

In this paper we reflect on the article, Science education in a bilingual class: problematising a translational practice, by Zeynep Ünsal, Britt Jakobson, Bengt-Olav Molander and Per-Olaf Wickman (Cult Stud Sci Educ, 10.1007/s11422-016-9747-3). In their article, the authors present the results of a classroom research project by responding to one main question: How is continuity between everyday language and the language of science construed in a bilingual science classroom where the teacher and the students do not speak the same minority language? Specifically, Ünsal et al. examine how bilingual students construe relations between everyday language and the language of science in a class taught in Swedish, in which all students also spoke Turkish, whereas the teacher also spoke Bosnian, both being minority languages in the context of Swedish schools. In this forum, we briefly discuss why close attention to bilingual dynamics emerging in classrooms such as those highlighted by Ünsal et al. matters for science education. We continue by discussing changing ontologies in relation to linguistic diversity and education more generally. Recent research in bilingual immersion classroom settings in so-called "content" subjects such as Content and Language Integrated Learning, is then introduced, as we believe this research offers some significant insights in terms of how bilingualism contributes to knowledge building in subjects such as science. Finally, we offer some reflections in relation to the classroom interactional competence needed by teachers in linguistically diverse classrooms. In this way, we aim to further the discussion initiated by Ünsal et al. and to offer possible frameworks for future research on bilingualism in science education. In their article, Ünsal et al. conclude the analysis of the classroom data by arguing in favor of a translanguaging pedagogy, an approach to teaching and learning in which students' whole language repertoires are used as

Factors associated with trace evidence analyses and DNA findings among police reported cases of rape.

PubMed

Forr, Camilla; Schei, Berit; Stene, Lise Eilin; Ormstad, Kari; Hagemann, Cecilie Therese

2018-02-01

The aim of this study was to examine the association between victim, suspect and assault characteristics and (1) forensic analysis of trace evidence, (2) detection of spermatozoa and (3) DNA match in police-reported cases of rape/attempted rape. In addition, we explored whether DNA findings were associated with legal outcome. We conducted a retrospective, descriptive study based on police-reported rapes and attempted rapes of women  ≥16 years of age in Sør-Trøndelag Police District throughout 1997-2010. Police data were merged with information from the Sexual Assault Centre (SAC) at St. Olavs University Hospital, Trondheim, Norway. We used binary and multivariable logistic regression for the comparisons. We identified 324 victims (mean age 24 years). The police requested analysis in 135 (45%) of the 299 collected victim samples. The police decision to analyze was after adjustment associated with the victim being employed or under education, and a public venue, but not with interval from assault to sampling. Spermatozoa were detected in 79 (61%) of the analyzed cases, of which 71 were collected from victims within 24h. Interval from assault being <24h and reporting a penetrative assault remained associated with the findings of spermatozoa after adjustments. Forensic analyses of trace evidence collected from victim, suspect and/or venue disclosed matching DNA profiles in 57 (40%) of a total of 143 analyzed cases. Matching DNA profiles were associated with suspect being known to the victim and with the venue being private. A higher proportion of cases with a DNA match were prosecuted in court: 20 of the 29 cases prosecuted. However, despite a DNA match 35 cases were anyway dismissed because of insufficient evidence. Although many of the associations in our study were expected, it is still important to report the actual numbers to gain insight into the importance of a DNA match in legal proceedings. A substantial proportion of cases with DNA match was dismissed

Early skin-to-skin contact or incubator for very preterm infants: study protocol for a randomized controlled trial.

PubMed

Kristoffersen, Laila; Støen, Ragnhild; Rygh, Hilde; Sognnæs, Margunn; Follestad, Turid; Mohn, Hilde S; Nissen, Ingrid; Bergseng, Håkon

2016-12-12

Skin-to-skin care immediately following delivery is a common practice for term infants and has been shown to improve cardiorespiratory stability, facilitate early bonding, and promote breastfeeding. Since 2007, the use of skin-to-skin care has been practiced for preterm infants from 32 weeks of gestation in the delivery room at St. Olav's University Hospital. In the present study we aim to investigate whether skin-to-skin care following delivery is safe, and how it affects early and late outcomes compared to standard care for very preterm infants. A randomized controlled trial (RCT) of skin-to-skin care in the delivery room for very preterm infants born at gestational age 28 0 -31 6 weeks with birth weight >1000 grams. Infants with severe congenital malformations or need of intubation in the delivery room are excluded. A detailed checklist and a flowchart were prepared for the study, and all involved professionals (neonatologists, neonatal nurses, obstetricians, anesthesiologists, midwives) participated in medical simulation training prior to study start on February 1, 2014. A consultant in neonatology and a neonatal nurse are present at all deliveries. Infants with birth weight <1500 grams receive an intravenous line with glucose, amino acids, and caffeine citrate in the delivery room. Infants with gestational age <30 weeks are routinely put on continuous positive airway pressure (CPAP). After initial stabilization, infants are randomized to skin-to-skin care or are transferred to the nursery in an incubator. Primary outcome is cognitive development at 2 years measured with the Bayley Scales of Infant Development, Third Edition. Secondary outcomes are safety defined as hypothermia, respiratory failure, and/or cardiopulmonary resuscitation, physiological stability after birth and motor, language and cognitive development at 1 year for the child, and mental health measured with the State-Trait Anxiety Inventory (STAI) at discharge, and at 3 months and 2�

A comparison between various radiological techniques in the localization and analysis of impacted and supernumerary teeth.

PubMed

Ziegler, Christoph M; Klimowicz, Thomas R

2013-01-01

An increasing number of different types of commercial cone-beam computed tomography (CBCT) devices are available for three-dimensional (3D) imaging in the field of dental and maxillofacial radiology. When removing impacted or supernumerary teeth, surgical teams often operate adjacent significant anatomical structures such as nerves, vessels, adjacent teeth roots, and paranasal sinuses. It is therefore important to choose the appropriate surgical approach to avoid iatrogenic damage to the essential anatomical neighbouring structures. CBCT, also called digital volume tomography (DVT), can visualize impacted and supernumerary teeth in all standard planes, as well as multisectional 3D views. These devices have shown to be highly beneficial in the assessment of small bony lesions and maxillofacial injuries. However, it is still necessary to determine the effectiveness of such devices in the assessment of impacted and supernumerary teeth, in comparison to the conventional radiological methods of intraoral X-rays and panoramic X-rays. During a period of 2 years, a total of 61 patients of whom majority had impacted teeth or supernumerary elements in the frontal maxillary region were studied with CBCT and treated at the St. Olavs University Hospital. Patients were referred to our Department of Oral and Maxillofacial Surgery with both conventional and digital intraoral X-rays and/or panoramic X-rays. None had any acute infections or odontogenic abscesses, and most presented with asymptomatic impacted tooth. A comparison between the preoperative conventional and the CBCT images, the resulting diagnoses, and the intraoperative findings as "gold standard" were made and recorded in a compiled scoring sheet. The objects of interest were researched with the magnification method. Each patient was identified only with a patient number. In contrast to the conventional X-rays, the pre-surgical evaluation with the CBCT revealed detailed imaging of significant anatomical structures and

Trampoline injuries

PubMed Central

Nysted, M; Drogset, J O

2006-01-01

Objective To describe the mechanism, location and types of injury for all patients treated for trampoline‐associated injuries at St Olav's University Hospital, Trondheim, Norway, from March 2001to October 2004. Materials and methods Patients were identified from a National Injury Surveillance System. All patients were asked to complete a standard questionnaire at their first visit at the hospital. Most data were recorded prospectively, but data on the mechanism of injury, the number of participants on the trampoline at the time of injury, adult supervision and whether the activity occurred at school or in another organised setting were collected retrospectively. Results A total of 556 patients, 56% male and 44% female, were included. The mean age of patients was 11 (range 1–62) years. 77% of the injuries occurred on the body of the trampoline, including falls on to the mat, collisions with another jumper, falls on to the frame or the springs, and performing a somersault, whereas 22% of the people fell off the trampoline. In 74% of the cases, more than two people were on the trampoline, with as many as nine trampolinists noted at the time of injury. For children <11 years, 22% had adult supervision when the injury occurred. The most common types of injuries were fractures (36%) and injury to ligaments (36%). Injuries to the extremities predominated (79%), and the lower extremities were the most commonly injured part of the body (44%). A ligament injury in the ankle was the most often reported diagnosis (20%), followed by an overstretching of ligaments in the neck (8%) and a fracture of the elbow (7%). Regarding cervical injuries, two patients had cervical fractures and one patient had an atlantoaxial subluxation. Three patients with fractures in the elbow region reported an ulnar nerve neuropathy. 13% of the patients were hospitalised for a mean of 2.2 days. Conclusion Trampolining can cause serious injuries, especially in the neck and elbow areas of young

Trampoline injuries.

PubMed

Nysted, M; Drogset, J O

2006-12-01

To describe the mechanism, location and types of injury for all patients treated for trampoline-associated injuries at St Olav's University Hospital, Trondheim, Norway, from March 2001to October 2004. Patients were identified from a National Injury Surveillance System. All patients were asked to complete a standard questionnaire at their first visit at the hospital. Most data were recorded prospectively, but data on the mechanism of injury, the number of participants on the trampoline at the time of injury, adult supervision and whether the activity occurred at school or in another organised setting were collected retrospectively. A total of 556 patients, 56% male and 44% female, were included. The mean age of patients was 11 (range 1-62) years. 77% of the injuries occurred on the body of the trampoline, including falls on to the mat, collisions with another jumper, falls on to the frame or the springs, and performing a somersault, whereas 22% of the people fell off the trampoline. In 74% of the cases, more than two people were on the trampoline, with as many as nine trampolinists noted at the time of injury. For children <11 years, 22% had adult supervision when the injury occurred. The most common types of injuries were fractures (36%) and injury to ligaments (36%). Injuries to the extremities predominated (79%), and the lower extremities were the most commonly injured part of the body (44%). A ligament injury in the ankle was the most often reported diagnosis (20%), followed by an overstretching of ligaments in the neck (8%) and a fracture of the elbow (7%). Regarding cervical injuries, two patients had cervical fractures and one patient had an atlantoaxial subluxation. Three patients with fractures in the elbow region reported an ulnar nerve neuropathy. 13% of the patients were hospitalised for a mean of 2.2 days. Trampolining can cause serious injuries, especially in the neck and elbow areas of young children. The use of a trampoline is a high-risk activity

A Genetic Basis for Functional Hypothalamic Amenorrhea

PubMed Central

Caronia, Lisa M.; Martin, Cecilia; Welt, Corrine K.; Sykiotis, Gerasimos P.; Quinton, Richard; Thambundit, Apisadaporn; Avbelj, Magdalena; Dhruvakumar, Sadhana; Plummer, Lacey; Hughes, Virginia A.; Seminara, Stephanie B.; Boepple, Paul A.; Sidis, Yisrael; Crowley, William F.; Martin, Kathryn A.; Hall, Janet E.; Pitteloud, Nelly

2011-01-01

BACKGROUND Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by such stressors, but it is unknown whether this variability reflects a genetic predisposition to hypothalamic amenorrhea. We hypothesized that mutations in genes involved in idiopathic hypogonadotropic hypogonadism, a congenital form of GnRH deficiency, are associated with hypothalamic amenorrhea. METHODS We analyzed the coding sequence of genes associated with idiopathic hypogonadotropic hypogonadism in 55 women with hypothalamic amenorrhea and performed in vitro studies of the identified mutations. RESULTS Six heterozygous mutations were identified in 7 of the 55 patients with hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E and R756H), two in the prokineticin receptor 2 gene PROKR2 (R85H and L173R), one in the GnRH receptor gene GNRHR (R262Q), and one in the Kall-mann syndrome 1 sequence gene KAL1 (V371I). No mutations were found in a cohort of 422 controls with normal menstrual cycles. In vitro studies showed that FGFR1 G260E, FGFR1 R756H, and PROKR2 R85H are loss-of-function mutations, as has been previously shown for PROKR2 L173R and GNRHR R262Q. CONCLUSIONS Rare variants in genes associated with idiopathic hypogonadotropic hypogonadism are found in women with hypothalamic amenorrhea, suggesting that these mutations may contribute to the variable susceptibility of women to the functional changes in GnRH secretion that characterize hypothalamic amenorrhea. Our observations provide evidence for the role of rare variants in common multifactorial disease. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; ClinicalTrials.gov number, NCT00494169.) PMID:21247312

Uniting geology and craftsmanship to find the optimal soapstone for restoration of the Nidaros soapstone Cathedral in Norway

NASA Astrophysics Data System (ADS)

Aslaksen Aasly, Kari; Meyer, Gurli Birgitte; Kløve Keiding, Jakob; Langås, Rune; Lund, Vegard

2017-04-01

The Nidaros Cathedral situated in Trondheim, Norway is a restored cathedral resting on the remnants of an original medieval church sanctified St Olav. The cathedral became one of the most important sanctuary for pilgrimage during the Middle Ages and still is today. In a European context the cathedral, along with a certain group of other churches and monasteries in Norway, is unique by being build from soapstone (steatite). This talc and chlorite dominated metamorphic rock is relatively soft, heat resistant and dense making the material ideal for cooking pots, stoves and all kinds of utensils. Soapstone has therefore been appreciated, used and quarried since the Stone Age in Norway. At the onset of Christianity the choice of soapstone from harder rock types was not difficult for the building owners combining the vision of stone churches in Norway with the skills of wood carving traditions of local handicraftsmen. The best example is the Nidaros Cathedral built in the 11th to 14th century. In 1869, the Nidaros Cathedral Restoration Workshop (NDR) was founded with the purpose of restoring the cathedral using original craftsman's techniques and authentic materials. The restoration was originally completed in 1969, but is still ongoing due to weathering of certain used soapstone types. A major challenge remains to find soapstone resources of the right quality. Core issues relate to avoid rocks with cracks and cleavage, a demand for homogeneity, maintaining esthetic authenticity, resistance to weathering (disintegration) and last but not least the ultimatum of workability. Thus locating new soapstone resources depends strongly on geological understanding, quarry experience and stone carver's knowledge. The present work is based on close cooperation between stone carvers and geologists in a common goal of uniting knowledge and experience in defining qualities of soapstone for various purposes of restoration. Cooperate observations of geology and carving properties in the

Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial.

PubMed

Prestmo, Anders; Hagen, Gunhild; Sletvold, Olav; Helbostad, Jorunn L; Thingstad, Pernille; Taraldsen, Kristin; Lydersen, Stian; Halsteinli, Vidar; Saltnes, Turi; Lamb, Sarah E; Johnsen, Lars G; Saltvedt, Ingvild

2015-04-25

ward improved mobility at 4 months, compared with the usual orthopaedic care. The results suggest that the treatment of older patients with hip fractures should be organised as orthogeriatric care. Norwegian Research Council, Central Norway Regional Health Authority, St Olav Hospital Trust and Fund for Research and Innovation, Liaison Committee between Central Norway Regional Health Authority and the Norwegian University of Science and Technology, the Department of Neuroscience at the Norwegian University of Science and Technology, Foundation for Scientific and Industrial Research at the Norwegian Institute of Technology (SINTEF), and the Municipality of Trondheim. Copyright © 2015 Elsevier Ltd. All rights reserved.

PREFACE: The 6th Nordic Meeting on Nuclear Physics

NASA Astrophysics Data System (ADS)

Løvhøiden, G.; Thorsteinsen, T. F.; Vaagen, J. S.

1990-01-01

Humanities (NAVF), The Norwegian Physical Society, The Community of Karmøy, Hydro Aluminium Karmøy, Statoil, Laborel, Aanderaa Instruments and also by other local firms and institutions. The financial as well as practical support from all of these sources is gratefully acknowledged. We will in particular express our appreciation for the indispensable help from cand. real. Konrad Bardsen and his colleagues at the gymnasium where the daily scientific activity, and also major parts of the social program, took place. The meeting could not have been organized nor carried through without the professional help from Karen-Margrete Hovland, backed by her sister Alice and a team of hard-working graduate students from Bergen: Erling Andersen, Håvard Helstrup, Torbjørn Rogde and Espen Staubo. We thank all of our speakers for a smooth cooperation. * The logo of the meeting, Seidmennene på Skrattaskjaer (Old Norse: seidmann = "shaman", skrattasker = wizard or troll skerry) has resulted in colorful interpretations and comments. The organizing committee noticed, with satisfaction, that the logo had been correctly identified in one of the contributions. The still curious reader may read about this thousand year old historic event in the sagas of the NORSE KINGS by Snorri Sturluson, in the saga of Olav Trygvason.

A Skin Cancer Prevention Facial-Aging Mobile App for Secondary Schools in Brazil: Appearance-Focused Interventional Study.

PubMed

Brinker, Titus Josef; Heckl, Marlene; Gatzka, Martina; Heppt, Markus V; Resende Rodrigues, Henrique; Schneider, Sven; Sondermann, Wiebke; de Almeida E Silva, Carolina; Kirchberger, Michael C; Klode, Joachim; Enk, Alexander H; Knispel, Sarah; von Kalle, Christof; Stoffels, Ingo; Schadendorf, Dirk; Nakamura, Yasuhiro; Esser, Stefan; Assis, Aisllan; Bernardes-Souza, Breno

2018-03-09

, 87.2% agreement in males) and increased use of sun protection (n=197, 92.1% agreement in females vs n=123, 87.2% agreement in males) and independent of age or skin type. All medical students involved filled in a process evaluation revealing that they all perceived the intervention as effective and unproblematic, and that all pupils tried the app in their presence. The photoaging intervention was effective in changing behavioral predictors for UV protection in Brazilian adolescents. The predictors measured indicated an even higher prospective effectiveness in southeast Brazil than in Germany (>90% agreement in Brazil vs >60% agreement in Germany to both items that measured motivation to reduce UV exposure) in accordance with the theory of planned behavior. Medical students are capable of complete implementation. A randomized controlled trial measuring prospective effects in Brazil is planned as a result of this study. ©Titus Josef Brinker, Marlene Heckl, Martina Gatzka, Markus V Heppt, Henrique Resende Rodrigues, Sven Schneider, Wiebke Sondermann, Carolina de Almeida e Silva, Michael C Kirchberger, Joachim Klode, Alexander H Enk, Sarah Knispel, Christof von Kalle, Ingo Stoffels, Dirk Schadendorf, Yasuhiro Nakamura, Stefan Esser, Aisllan Assis, Breno Bernardes-Souza. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 09.03.2018.

EDITORIAL: Molecular switches at surfaces Molecular switches at surfaces

NASA Astrophysics Data System (ADS)

Weinelt, Martin; von Oppen, Felix

2012-10-01

electron-vibration coupling in transport through single moleculesKatharina J Franke and Jose Ignacio Pascual Vibrational heating in single-molecule switches: an energy-dependent density-of-states approachT Brumme, R Gutierrez and G Cuniberti Reversible switching of single tin phthalocyanine molecules on the InAs(111)A surfaceC Nacci, K Kanisawa and S Fölsch Tuning the interaction between carbon nanotubes and dipole switches: the influence of the change of the nanotube-spiropyran distanceP Bluemmel, A Setaro, C Maity, S Hecht and S Reich Carbon nanotubes as substrates for molecular spiropyran-based switchesE Malic, A Setaro, P Bluemmel, Carlos F Sanz-Navarro, Pablo Ordejón, S Reich and A Knorr Ultrafast dynamics of dithienylethenes differently linked to the surface of TiO2 nanoparticlesLars Dworak, Marc Zastrow, Gehad Zeyat, Karola Rück-Braun and Josef Wachtveitl Switching the electronic properties of Co-octaethylporphyrin molecules on oxygen-covered Ni films by NO adsorptionC F Hermanns, M Bernien, A Krüger, J Miguel and W Kuch STM-switching of organic molecules on semiconductor surfaces: an above threshold density matrix model for 1,5 cyclooctadiene on Si(100)K Zenichowski, Ch Nacci, S Fölsch, J Dokić, T Klamroth and P Saalfrank A switch based on self-assembled thymineFatih Kalkan, Michael Mehlhorn and Karina Morgenstern The growth and electronic structure of azobenzene-based functional molecules on layered crystalsJ Iwicki, E Ludwig, J Buck, M Kalläne, F Köhler, R Herges, L Kipp and K Rossnagel Voltage-dependent conductance states of a single-molecule junctionY F Wang, N Néel, J Kröger, H Vázquez, M Brandbyge, B Wang and R Berndt Molecules with multiple switching units on a Au(111) surface: self-organization and single-molecule manipulationJohannes Mielke, Sofia Selvanathan, Maike Peters, Jutta Schwarz, Stefan Hecht and Leonhard Grill Preparing and regulating a bi-stable molecular switch by atomic manipulationS Sakulsermsuk, R E Palmer and P A Sloan Mixed self

EDITORIAL: Focus on Micro- and Nanofluidics FOCUS ON MICRO- AND NANOFLUIDICS

NASA Astrophysics Data System (ADS)

Ajdari, Armand; Stone, Howard A.

2009-07-01

, simulation and theory, in this rapidly developing field. Focus on Micro- and Nanofluidics Contents The anti-lotus leaf effect in nanohydrodynamic bump arrays Keith Morton, Ophelia K C Tsui, Chih-Kuan Tung, James C Sturm, Stephen Y Chou and Robert Austin Transport in nanofluidic systems: a review of theory and applications W Sparreboom, A van den Berg and J C T Eijkel The effects of polymer molecular weight on filament thinning and drop breakup in microchannels P E Arratia, L-A Cramer, J P Gollub and D J Durian Mass transfer and interfacial properties in two-phase microchannel flows Jeffrey D Martin and Steven D Hudson Temporal response of an initially deflected PDMS channel Priyadarshi Panda, Kai P Yuet, Dhananjay Dendukuri, T Alan Hatton and Patrick S Doyle Gas-liquid two-phase flow patterns in rectangular polymeric microchannels: effect of surface wetting properties D Huh, C-H Kuo, J B Grotberg and S Takayama Mixing via thermocapillary generation of flow patterns inside a microfluidic drop María Luisa Cordero, Hans Olav Rolfsnes, Daniel R Burnham, Paul A Campbell, David McGloin and Charles N Baroud Pressure-driven DNA transport across an artificial nanotopography J T Del Bonis-O'Donnell, W Reisner and D Stein Eulerian indicators for predicting and optimizing mixing quality Rob Sturman and Stephen Wiggins Asymmetric flows over symmetric surfaces: capacitive coupling in induced-charge electro-osmosis T S Mansuripur, A J Pascall and T M Squires High-viscosity fluid threads in weakly diffusive microfluidic systems T Cubaud and T G Mason Interfacial mass transport in steady three-dimensional flows in microchannels Joseph D Kirtland, Corey R Siegel and Abraham D Stroock Active connectors for microfluidic drops on demand Jean-Christophe Galas, Denis Bartolo and Vincent Studer Electrokinetic control of sample splitting at a channel bifurcation using isotachophoresis Alexandre Persat and Juan G Santiago Differential inertial focusing of particles in curved low

PREFACE: CEWQO Topical Issue CEWQO Topical Issue

NASA Astrophysics Data System (ADS)

Bozic, Mirjana; Man'ko, Margarita

2009-09-01

Kalle-Antti Suominen (http://www.congress.utu.fi/cewqo2009). The conference site is the new ICT building at chaired by Professor Kalle-Antti Suominen (http://www.congress.utu.fi/cewqo2009, www.congress.utu.fi/cewqo2009). The conference site was the new ICT building at the University of Turku campus area and the Viking Line ferry boat. Turku is the central city of historical Finland established on the mouth of the river Aura in the 13th century. It is the birthplace of Finnish academic life, since the Academy of Turku was established there in 1640. In 2011, Turku will be one of the cultural capitals of Europe. The city has a strong maritime tradition and is shielded from the Baltic sea by a large and beautiful archipelago. The 17th Central European Workshop on Quantum Optics will be held in 2010 in St Andrews, UK. It will be chaired by Professors Ulf Leonhardt and Natalia Korolkova from the School of Physics and Astronomy, University of St Andrews. St Andrews is home to the first university of Scotland, the third-oldest in the English-speaking world, and is the home of golf. It remains a charming, eccentric seaside town that is sufficiently secluded - the ideal place for a stimulating and thought-provoking conference.

FOREWORD: The 70th birthday of Professor Stig Stenholm The 70th birthday of Professor Stig Stenholm

NASA Astrophysics Data System (ADS)

Suominen, Kalle-Antti

2010-09-01

information [7] and in Stockholm he had, again, very successful postdocs such as Ulf Leonhardt. Finally, in 2005, Stig Stenholm retired, although he is still active, writing papers, taking part in conferences and making research visits. We honoured his 70th birthday at the CEWQO2009 conference, and hope that the future provides us with further opportunities for such events. Looking at the obituary of Dirk ter Haar, I see that his style with students reminds me of Stig's approach. In my opinion, Stig expects independence and initiative from a student, giving perhaps a broad topic in which the student is expected to find his or her own way, whilst working perhaps with a postdoc. Juha Javanainen has talked about the 'sink or swim' style (not referring to Stig, though). There is a famous series of children's books about Moomin trolls by Tove Jansson (another Swedish-speaking Finn like Stig). In one of them, the Moomin find in early spring a small flower in a patch of land uncovered by snow, pushing its way up. One of them wants to cover it against frost during the night, but another says 'Don't, it'll fare better later if it has some difficulties at first'. At CEWQO2009 Stig gave the full list of his finished PhD students: Rainer Salomaa (1973), Temba Dlodlo (1980), Juha Javanainen (1980), Markus Lindberg (1985), Matti Kaivola (1985), Birger Ståhlberg (1985), Kalle-Antti Suominen (1992), Mackillo Kira (1995), Päivi Törmä (1996), Asta Paloviita (1997), Patrik Öhberg (1998), Martti Havukainen (1999), Erika Andersson (2000), Pawel Piwnicki (2001), Åsa Larson (2001), Markku Jääskeläinen (2003), and Jonas Larson (2005). One should also mention Erkki Kyrölä, who eventually graduated at Rochester and Olli Serimaa, who never graduated but published some important early-stage laser cooling work. As a final note I must mention a passion that Stig and I share, namely books. I have nearly 400 professional physics and mathematics books, but I am certain that the size of Stig

Commentary on "integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer." Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T, Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.: Cancer Cell 2013;23(2):159-70.

PubMed

Olumi, Aria F

2014-02-01

Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in 11 tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of>10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA. Copyright © 2014 Elsevier Inc. All rights reserved.