Sample records for kalni anda dzene

  1. Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).

    PubMed

    Raw, Andre S; Furness, M Scott; Gill, Devinder S; Adams, Richard C; Holcombe, Frank O; Yu, Lawrence X

    2004-02-23

    A sponsor of an Abbreviated New Drug Application (ANDA) must have information to show that the proposed generic product and the innovator product are both pharmaceutically equivalent and bioequivalent, and therefore, therapeutically equivalent. Many pharmaceutical solids exist in several crystalline forms and thus exhibit polymorphism. Polymorphism may result in differences in the physico-chemical properties of the active ingredient and variations in these properties may render a generic drug product to be bioinequivalent to the innovator brand. For this reason, in ANDAs, careful attention is paid to the effect of polymorphism in the context of generic drug product equivalency. This review discusses the impact of polymorphism on drug product manufacturability, quality, and performance. Conclusions from this analysis demonstrate that pharmaceutical solid polymorphism has no relevance to the determination of drug substance "sameness" in ANDAs. Three decision trees for solid oral dosage forms or liquid suspensions are provided for evaluating when and how polymorphs of drug substances should be monitored and controlled in ANDA submissions. Case studies from ANDAs are provided which demonstrate the irrelevance of polymorphism to the determination of drug substance "sameness". These case studies also illustrate the conceptual framework from these decision trees and illustrate how their general principles are sufficient to assure both the quality and the therapeutic equivalence of marketed generic drug products.

  2. Implementation of the P barANDA Planar-GEM tracking detector in Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Divani Veis, Nazila; Ehret, Andre; Firoozabadi, Mohammad M.; Karabowicz, Radoslaw; Maas, Frank; Saito, Nami; Saito, Takehiko R.; Voss, Bernd; PANDA Gem-Tracker Subgroup

    2018-02-01

    The P barANDA experiment at FAIR will be performed to investigate different aspects of hadron physics using anti-proton beams interacting with a fixed nuclear target. The experimental setup consists of a complex series of detector components covering a large solid angle. A detector with a gaseous active media equipped with gas electron multiplier (GEM) technique will be employed to measure tracks of charged particles at forward direction in order to achieve a high momentum resolution. In this work, a full setup of the GEM tracking detector has been implemented in the P barANDA Monte Carlo simulation package (PandaRoot) based on the current technical and conceptual design, and the expected performance of the P barANDA GEM-tracking detector has been investigated. Furthermore, material-budget studies in terms of the radiation length of the P barANDA GEM-tracking detector have been made in order to investigate the effect of the detector materials and its associated structures to particle measurements.

  3. Performance studies of the P barANDA planar GEM-tracking detector in physics simulations

    NASA Astrophysics Data System (ADS)

    Divani Veis, Nazila; Firoozabadi, Mohammad M.; Karabowicz, Radoslaw; Maas, Frank; Saito, Takehiko R.; Voss, Bernd; ̅PANDA Gem-Tracker Subgroup

    2018-03-01

    The P barANDA experiment will be installed at the future facility for antiproton and ion research (FAIR) in Darmstadt, Germany, to study events from the annihilation of protons and antiprotons. The P barANDA detectors can cover a wide physics program about baryon spectroscopy and nucleon structure as well as the study of hadrons and hypernuclear physics including the study of excited hyperon states. One very specific feature of most hyperon ground states is the long decay length of several centimeters in the forward direction. The central tracking detectors of the P barANDA setup are not sufficiently optimized for these long decay lengths. Therefore, using a set of the planar GEM-tracking detectors in the forward region of interest can improve the results in the hyperon physics-benchmark channel. The current conceptual designed P barANDA GEM-tracking stations contribute the measurement of the particles emitted in the polar angles between about 2 to 22 degrees. For this designed detector performance and acceptance, studies have been performed using one of the important hyperonic decay channel p bar p → Λ bar Λ → p bar pπ+π- in physics simulations. The simulations were carried out using the PandaRoot software packages based on the FairRoot framework.

  4. The bar{P}ANDA Experiment at FAIR — Subatomic Physics with Antiprotons

    NASA Astrophysics Data System (ADS)

    Messchendorp, Johan

    The non-perturbative nature of the strong interaction leads to spectacular phenomena, such as the formation of hadronic matter, color confinement, and the generation of the mass of visible matter. To get deeper insight into the underlying mechanisms remains one of the most challenging tasks within the field of subatomic physics. The antiProton ANnihilations at DArmstadt (bar{P}ANDA) collaboration has the ambition to address key questions in this field by exploiting a cooled beam of antiprotons at the High Energy Storage Ring (HESR) at the future Facility for Antiproton and Ion Research (FAIR) combined with a state-of-the-art and versatile detector. This contribution will address some of the unique features of bar{P}ANDA that give rise to a promising physics program together with state-of-the-art technological developments.

  5. Experimental access to Transition Distribution Amplitudes with the P¯ANDA experiment at FAIR

    NASA Astrophysics Data System (ADS)

    Singh, B. P.; Erni, W.; Keshelashvili, I.; Krusche, B.; Steinacher, M.; Liu, B.; Liu, H.; Liu, Z.; Shen, X.; Wang, C.; Zhao, J.; Albrecht, M.; Fink, M.; Heinsius, F. H.; Held, T.; Holtmann, T.; Koch, H.; Kopf, B.; Kümmel, M.; Kuhl, G.; Kuhlmann, M.; Leyhe, M.; Mikirtychyants, M.; Musiol, P.; Mustafa, A.; Pelizäus, M.; Pychy, J.; Richter, M.; Schnier, C.; Schröder, T.; Sowa, C.; Steinke, M.; Triffterer, T.; Wiedner, U.; Beck, R.; Hammann, C.; Kaiser, D.; Ketzer, B.; Kube, M.; Mahlberg, P.; Rossbach, M.; Schmidt, C.; Schmitz, R.; Thoma, U.; Walther, D.; Wendel, C.; Wilson, A.; Bianconi, A.; Bragadireanu, M.; Caprini, M.; Pantea, D.; Pietreanu, D.; Vasile, M. E.; Patel, B.; Kaplan, D.; Brandys, P.; Czyzewski, T.; Czyzycki, W.; Domagala, M.; Hawryluk, M.; Filo, G.; Krawczyk, M.; Kwiatkowski, D.; Lisowski, E.; Lisowski, F.; Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K.; Czech, B.; Kliczewski, S.; Korcyl, K.; Kozela, A.; Kulessa, P.; Lebiedowicz, P.; Malgorzata, K.; Pysz, K.; Schäfer, W.; Siudak, R.; Szczurek, A.; Biernat, J.; Jowzaee, S.; Kamys, B.; Kistryn, S.; Korcyl, G.; Krzemien, W.; Magiera, A.; Moskal, P.; Palka, M.; Psyzniak, A.; Rudy, Z.; Salabura, P.; Smyrski, J.; Strzempek, P.; Wrońska, A.; Augustin, I.; Lehmann, I.; Nicmorus, D.; Schepers, G.; Schmitt, L.; Al-Turany, M.; Cahit, U.; Capozza, L.; Dbeyssi, A.; Deppe, H.; Dzhygadlo, R.; Ehret, A.; Flemming, H.; Gerhardt, A.; Götzen, K.; Karabowicz, R.; Kliemt, R.; Kunkel, J.; Kurilla, U.; Lehmann, D.; Lühning, J.; Maas, F.; Morales Morales, C.; Mora Espí, M. C.; Nerling, F.; Orth, H.; Peters, K.; Rodríguez Piñeiro, D.; Saito, N.; Saito, T.; Sánchez Lorente, A.; Schmidt, C. J.; Schwarz, C.; Schwiening, J.; Traxler, M.; Valente, R.; Voss, B.; Wieczorek, P.; Wilms, A.; Zühlsdorf, M.; Abazov, V. M.; Alexeev, G.; Arefiev, A.; Astakhov, V. I.; Barabanov, M. Yu.; Batyunya, B. V.; Davydov, Yu. I.; Dodokhov, V. Kh.; Efremov, A. A.; Fedunov, A. G.; Festchenko, A. A.; Galoyan, A. S.; Grigoryan, S.; Karmokov, A.; Koshurnikov, E. K.; Lobanov, V. I.; Lobanov, Yu. Yu.; Makarov, A. F.; Malinina, L. V.; Malyshev, V. L.; Mustafaev, G. A.; Olshevskiy, A.; Pasyuk, M. A.; Perevalova, E. A.; Piskun, A. A.; Pocheptsov, T. A.; Pontecorvo, G.; Rodionov, V. K.; Rogov, Yu. N.; Salmin, R. A.; Samartsev, A. G.; Sapozhnikov, M. G.; Shabratova, G. S.; Skachkov, N. B.; Skachkova, A. N.; Strokovsky, E. A.; Suleimanov, M. K.; Teshev, R. Sh.; Tokmenin, V. V.; Uzhinsky, V. V.; Vodopyanov, A. S.; Zaporozhets, S. A.; Zhuravlev, N. I.; Zorin, A. G.; Branford, D.; Glazier, D.; Watts, D.; Woods, P.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Dobbs, S.; Seth, K.; Tomaradze, A.; Xiao, T.; Bettoni, D.; Carassiti, V.; Cotta Ramusino, A.; Dalpiaz, P.; Drago, A.; Fioravanti, E.; Garzia, I.; Savriè, M.; Stancari, G.; Akishina, V.; Kisel, I.; Kulakov, I.; Zyzak, M.; Arora, R.; Bel, T.; Gromliuk, A.; Kalicy, G.; Krebs, M.; Patsyuk, M.; Zuehlsdorf, M.; Bianchi, N.; Gianotti, P.; Guaraldo, C.; Lucherini, V.; Pace, E.; Bersani, A.; Bracco, G.; Macri, M.; Parodi, R. F.; Bianco, S.; Bremer, D.; Brinkmann, K. T.; Diehl, S.; Dormenev, V.; Drexler, P.; Düren, M.; Eissner, T.; Etzelmüller, E.; Föhl, K.; Galuska, M.; Gessler, T.; Gutz, E.; Hayrapetyan, A.; Hu, J.; Kröck, B.; Kühn, W.; Kuske, T.; Lange, S.; Liang, Y.; Merle, O.; Metag, V.; Mülhheim, D.; Münchow, D.; Nanova, M.; Novotny, R.; Pitka, A.; Quagli, T.; Rieke, J.; Rosenbaum, C.; Schnell, R.; Spruck, B.; Stenzel, H.; Thöring, U.; Ullrich, M.; Wasem, T.; Werner, M.; Zaunick, H. G.; Ireland, D.; Rosner, G.; Seitz, B.; Deepak, P. N.; Kulkarni, A. V.; Apostolou, A.; Babai, M.; Kavatsyuk, M.; Lemmens, P.; Lindemulder, M.; Löhner, H.; Messchendorp, J.; Schakel, P.; Smit, H.; van der Weele, J. C.; Tiemens, M.; Veenstra, R.; Vejdani, S.; Kalita, K.; Mohanta, D. P.; Kumar, A.; Roy, A.; Sahoo, R.; Sohlbach, H.; Büscher, M.; Cao, L.; Cebulla, A.; Deermann, D.; Dosdall, R.; Esch, S.; Georgadze, I.; Gillitzer, A.; Goerres, A.; Goldenbaum, F.; Grunwald, D.; Herten, A.; Hu, Q.; Kemmerling, G.; Kleines, H.; Kozlov, V.; Lehrach, A.; Leiber, S.; Maier, R.; Nellen, R.; Ohm, H.; Orfanitski, S.; Prasuhn, D.; Prencipe, E.; Ritman, J.; Schadmand, S.; Schumann, J.; Sefzick, T.; Serdyuk, V.; Sterzenbach, G.; Stockmanns, T.; Wintz, P.; Wüstner, P.; Xu, H.; Li, S.; Li, Z.; Sun, Z.; Xu, H.; Rigato, V.; Fissum, S.; Hansen, K.; Isaksson, L.; Lundin, M.; Schröder, B.; Achenbach, P.; Bleser, S.; Cardinali, M.; Corell, O.; Deiseroth, M.; Denig, A.; Distler, M.; Feldbauer, F.; Fritsch, M.; Jasinski, P.; Hoek, M.; Kangh, D.; Karavdina, A.; Lauth, W.; Leithoff, H.; Merkel, H.; Michel, M.; Motzko, C.; Müller, U.; Noll, O.; Plueger, S.; Pochodzalla, J.; Sanchez, S.; Schlimme, S.; Sfienti, C.; Steinen, M.; Thiel, M.; Weber, T.; Zambrana, M.; Dormenev, V. I.; Fedorov, A. A.; Korzihik, M. V.; Missevitch, O. V.; Balanutsa, P.; Balanutsa, V.; Chernetsky, V.; Demekhin, A.; Dolgolenko, A.; Fedorets, P.; Gerasimov, A.; Goryachev, V.; Varentsov, V.; Boukharov, A.; Malyshev, O.; Marishev, I.; Semenov, A.; Konorov, I.; Paul, S.; Grieser, S.; Hergemöller, A. K.; Khoukaz, A.; Köhler, E.; Täschner, A.; Wessels, J.; Dash, S.; Jadhav, M.; Kumar, S.; Sarin, P.; Varma, R.; Chandratre, V. B.; Datar, V.; Dutta, D.; Jha, V.; Kumawat, H.; Mohanty, A. K.; Roy, B.; Yan, Y.; Chinorat, K.; Khanchai, K.; Ayut, L.; Pornrad, S.; Barnyakov, A. Y.; Blinov, A. E.; Blinov, V. E.; Bobrovnikov, V. S.; Kononov, S. A.; Kravchenko, E. A.; Kuyanov, I. A.; Onuchin, A. P.; Sokolov, A. A.; Tikhonov, Y. A.; Atomssa, E.; Hennino, T.; Imre, M.; Kunne, R.; Le Galliard, C.; Ma, B.; Marchand, D.; Ong, S.; Ramstein, B.; Rosier, P.; Tomasi-Gustafsson, E.; Van de Wiele, J.; Boca, G.; Costanza, S.; Genova, P.; Lavezzi, L.; Montagna, P.; Rotondi, A.; Abramov, V.; Belikov, N.; Bukreeva, S.; Davidenko, A.; Derevschikov, A.; Goncharenko, Y.; Grishin, V.; Kachanov, V.; Kormilitsin, V.; Melnik, Y.; Levin, A.; Minaev, N.; Mochalov, V.; Morozov, D.; Nogach, L.; Poslavskiy, S.; Ryazantsev, A.; Ryzhikov, S.; Semenov, P.; Shein, I.; Uzunian, A.; Vasiliev, A.; Yakutin, A.; Yabsley, B.; Bäck, T.; Cederwall, B.; Makónyi, K.; Tegnér, P. E.; von Würtemberg, K. M.; Belostotski, S.; Gavrilov, G.; Izotov, A.; Kashchuk, A.; Levitskaya, O.; Manaenkov, S.; Miklukho, O.; Naryshkin, Y.; Suvorov, K.; Veretennikov, D.; Zhadanov, A.; Rai, A. K.; Godre, S. S.; Duchat, R.; Amoroso, A.; Bussa, M. P.; Busso, L.; De Mori, F.; Destefanis, M.; Fava, L.; Ferrero, L.; Greco, M.; Maggiora, M.; Maniscalco, G.; Marcello, S.; Sosio, S.; Spataro, S.; Zotti, L.; Calvo, D.; Coli, S.; De Remigis, P.; Filippi, A.; Giraudo, G.; Lusso, S.; Mazza, G.; Mingnore, M.; Rivetti, A.; Wheadon, R.; Balestra, F.; Iazzi, F.; Introzzi, R.; Lavagno, A.; Younis, H.; Birsa, R.; Bradamante, F.; Bressan, A.; Martin, A.; Clement, H.; Gålnander, B.; Caldeira Balkeståhl, L.; Calén, H.; Fransson, K.; Johansson, T.; Kupsc, A.; Marciniewski, P.; Pettersson, J.; Schönning, K.; Wolke, M.; Zlomanczuk, J.; Díaz, J.; Ortiz, A.; Vinodkumar, P. C.; Parmar, A.; Chlopik, A.; Melnychuk, D.; Slowinski, B.; Trzcinski, A.; Wojciechowski, M.; Wronka, S.; Zwieglinski, B.; Bühler, P.; Marton, J.; Suzuki, K.; Widmann, E.; Zmeskal, J.; Fröhlich, B.; Khaneft, D.; Lin, D.; Zimmermann, I.; Semenov-Tian-Shansky, K.

    2015-08-01

    Baryon-to-meson Transition Distribution Amplitudes (TDAs) encoding valuable new information on hadron structure appear as building blocks in the collinear factorized description for several types of hard exclusive reactions. In this paper, we address the possibility of accessing nucleon-to-pion ( πN) TDAs from reaction with the future P¯ANDA detector at the FAIR facility. At high center-of-mass energy and high invariant mass squared of the lepton pair q 2, the amplitude of the signal channel admits a QCD factorized description in terms of πN TDAs and nucleon Distribution Amplitudes (DAs) in the forward and backward kinematic regimes. Assuming the validity of this factorized description, we perform feasibility studies for measuring with the P¯ANDA detector. Detailed simulations on signal reconstruction efficiency as well as on rejection of the most severe background channel, i.e. were performed for the center-of-mass energy squared s = 5 GeV2 and s = 10 GeV2, in the kinematic regions 3.0 < q 2 < 4.3 GeV2 and 5 < q 2 GeV2, respectively, with a neutral pion scattered in the forward or backward cone in the proton-antiproton center-of-mass frame. Results of the simulation show that the particle identification capabilities of the P¯ANDA detector will allow to achieve a background rejection factor of 5 · 107 (1 · 107) at low (high) q 2 for s = 5 GeV2, and of 1 · 108 (6 · 106) at low (high) q 2 for s = 10 GeV2, while keeping the signal reconstruction efficiency at around 40%. At both energies, a clean lepton signal can be reconstructed with the expected statistics corresponding to 2 fb-1 of integrated luminosity. The cross sections obtained from the simulations are used to show that a test of QCD collinear factorization can be done at the lowest order by measuring scaling laws and angular distributions. The future measurement of the signal channel cross section with P¯ANDA will provide a new test of the perturbative QCD description of a novel class of hard

  6. Overview of the Micro Vertex Detector for the P bar ANDA experiment

    NASA Astrophysics Data System (ADS)

    Calvo, Daniela; P¯ANDA MVD Group

    2017-02-01

    The P bar ANDA experiment is devoted to study interactions between cooled antiproton beams and a fixed target (the interaction rate is of about 107 events/s), hydrogen or heavier nuclei. The innermost tracker of P bar ANDA is the Micro Vertex Detector (MVD), specially designed to ensure the secondary vertex resolution for the discrimination of short-lived charmonium states. Hybrid epitaxial silicon pixels and double-sided silicon microstrips will equip four barrels, arranged around the interaction point, and six forward disks. The experiment features a triggerless architecture with a master clock of 160 MHz, therefore the MVD has to run with a continuous data transmission where the hits need precise timestamps. The energy loss of the particles in the sensor will be measured as well. The challenging request of a triggerless readout suggested to develop custom readout chips for both pixel (ToPix) and microstrip (PASTA) devices. To validate components and the triggerless readout architecture, prototypes have been built and tested. After an overview of the MVD, the technological aspects and performances of some prototypes will be reported.

  7. FairMQ for Online Reconstruction - An example on \\overline{{\\rm{P}}}ANDA test beam data

    NASA Astrophysics Data System (ADS)

    Stockmanns, Tobias; PANDA Collaboration

    2017-10-01

    One of the large challenges of future particle physics experiments is the trend to run without a first level hardware trigger. The typical data rates exceed easily hundreds of GBytes/s, which is way too much to be stored permanently for an offline analysis. Therefore a strong data reduction has to be done by selection of only those data, which are physically interesting. This implies that all detector data are read out and have to be processed with the same rate as it is produced. Several different hardware approaches from FPGAs, GPUs to multicore CPUs and mixtures of these systems are under study. Common to all of them is the need to process the data in massive parallel systems. One very convenient way to realize parallel systems on heterogeneous systems is the usage of message queue based multiprocessing. One package that allow development of such application is the FairMQ module in the FairRoot simulation framework developed at GSI. FairRoot is used by several different experiments at and outside the GSI including the \\overline{{{P}}}ANDA experiment. FairMQ is an abstract layer for message queue base application, it has up to now two implementations: ZeroMQ and nanomsg. For the \\overline{{{P}}}ANDA experiment, FairMQ is under test in two different ways. On the one hand side for online processing test beam data of prototypes of sub-detectors of \\overline{{{P}}}ANDA and, in a more generalized way, on time-based simulated data of the complete detector system. The first test on test beam data is presented in this paper.

  8. Technical design report for the overline{P}ANDA (Anti Proton Annihilations at Darmstadt) Straw Tube Tracker. Strong interaction studies with antiprotons

    NASA Astrophysics Data System (ADS)

    Erni, W.; Keshelashvili, I.; Krusche, B.; Steinacher, M.; Heng, Y.; Liu, Z.; Liu, H.; Shen, X.; Wang, Q.; Xu, H.; Aab, A.; Albrecht, M.; Becker, J.; Csapó, A.; Feldbauer, F.; Fink, M.; Friedel, P.; Heinsius, F. H.; Held, T.; Klask, L.; Koch, H.; Kopf, B.; Leiber, S.; Leyhe, M.; Motzko, C.; Pelizäus, M.; Pychy, J.; Roth, B.; Schröder, T.; Schulze, J.; Sowa, C.; Steinke, M.; Trifterer, T.; Wiedner, U.; Zhong, J.; Beck, R.; Bianco, S.; Brinkmann, K. T.; Hammann, C.; Hinterberger, F.; Kaiser, D.; Kliemt, R.; Kube, M.; Pitka, A.; Quagli, T.; Schmidt, C.; Schmitz, R.; Schnell, R.; Thoma, U.; Vlasov, P.; Walther, D.; Wendel, C.; Würschig, T.; Zaunick, H. G.; Bianconi, A.; Bragadireanu, M.; Caprini, M.; Pantea, D.; Pantelica, D.; Pietreanu, D.; Serbina, L.; Tarta, P. D.; Kaplan, D.; Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K.; Czech, B.; Kistryn, M.; Kliczewski, S.; Kozela, A.; Kulessa, P.; Lebiedowicz, P.; Pysz, K.; Schäfer, W.; Siudak, R.; Szczurek, A.; Jowzaee, S.; Kajetanowicz, M.; Kamys, B.; Kistryn, S.; Korcyl, G.; Korcyl, K.; Krzemien, W.; Magiera, A.; Moskal, P.; Palka, M.; Rudy, Z.; Salabura, P.; Smyrski, J.; Wrońska, A.; Augustin, I.; Lehmann, I.; Nimorus, D.; Schepers, G.; Al-Turany, M.; Arora, R.; Deppe, H.; Flemming, H.; Gerhardt, A.; Götzen, K.; Jordi, A. F.; Kalicy, G.; Karabowicz, R.; Lehmann, D.; Lewandowski, B.; Lühning, J.; Maas, F.; Orth, H.; Patsyuk, M.; Peters, K.; Saito, T.; Schepers, G.; Schmidt, C. J.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Voss, B.; Wieczorek, P.; Wilms, A.; Zühlsdorf, M.; Abazov, V. M.; Alexeev, G.; Arefiev, A.; Astakhov, V. I.; Barabanov, M. Yu.; Batyunya, B. V.; Davydov, Yu. I.; Dodokhov, V. Kh.; Efremov, A. A.; Fedunov, A. G.; Festchenko, A. A.; Galoyan, A. S.; Grigoryan, S.; Karmokov, A.; Koshurnikov, E. K.; Lobanov, V. I.; Lobanov, Yu. Yu.; Makarov, A. F.; Malinina, L. V.; Malyshev, V. L.; Mustafaev, G. A.; Olshevskiy, A.; Pasyuk, M. A.; Perevalova, E. A.; Piskun, A. A.; Pocheptsov, T. A.; Pontecorvo, G.; Rodionov, V. K.; Rogov, Yu. N.; Salmin, R. A.; Samartsev, A. G.; Sapozhnikov, M. G.; Shabratova, G. S.; Skachkova, A. N.; Skachkov, N. B.; Strokovsky, E. A.; Suleimanov, M. K.; Teshev, R. Sh.; Tokmenin, V. V.; Uzhinsky, V. V.; Vodopyanov, A. S.; Zaporozhets, S. A.; Zhuravlev, N. I.; Zorin, A. G.; Branford, D.; Glazier, D.; Watts, D.; Woods, P.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Dobbs, S.; Metreveli, Z.; Seth, K.; Tomaradze, A.; Xiao, T.; Bettoni, D.; Carassiti, V.; Cotta Ramusino, A.; Dalpiaz, P.; Drago, A.; Fioravanti, E.; Garzia, I.; Savriè, M.; Stancari, G.; Bianchi, N.; Gianotti, P.; Guaraldo, C.; Lucherini, V.; Orecchini, D.; Pace, E.; Bersani, A.; Bracco, G.; Macri, M.; Parodi, R. F.; Bremer, D.; Dormenev, V.; Drexler, P.; Düren, M.; Eissner, T.; Föhl, K.; Galuska, M.; Gessler, T.; Hayrapetyan, A.; Hu, J.; Koch, P.; Kröck, B.; Kühn, W.; Lange, S.; Liang, Y.; Merle, O.; Metag, V.; Moritz, M.; Münchow, D.; Nanova, M.; Novotny, R.; Spruck, B.; Stenzel, H.; Ullrich, T.; Werner, M.; Xu, H.; Euan, C.; Hoek, M.; Ireland, D.; Keri, T.; Montgomery, R.; Protopopescu, D.; Rosner, G.; Seitz, B.; Babai, M.; Glazenborg-Kluttig, A.; Kavatsyuk, M.; Lemmens, P.; Lindemulder, M.; Löhner, H.; Messchendorp, J.; Moeini, H.; Schakel, P.; Schreuder, F.; Smit, H.; Tambave, G.; van der Weele, J. C.; Veenstra, R.; Sohlbach, H.; Büscher, M.; Deermann, D.; Dosdall, R.; Esch, S.; Gillitzer, A.; Goldenbaum, F.; Grunwald, D.; Henssler, S.; Herten, A.; Hu, Q.; Kemmerling, G.; Kleines, H.; Kozlov, V.; Lehrach, A.; Maier, R.; Mertens, M.; Ohm, H.; Orfanitski, S.; Prasuhn, D.; Randriamalala, T.; Ritman, J.; Röder, M.; Schadmand, S.; Serdyuk, V.; Sterzenbach, G.; Stockmanns, T.; Wintz, P.; Wüstner, P.; Xu, H.; Kisiel, J.; Li, S.; Li, Z.; Sun, Z.; Xu, H.; Rigato, V.; Fissum, S.; Hansen, K.; Isaksson, L.; Lundin, M.; Schröder, B.; Achenbach, P.; Bleser, S.; Cahit, U.; Cardinali, M.; Denig, A.; Distler, M.; Fritsch, M.; Jasinski, P.; Kangh, D.; Karavdina, A.; Lauth, W.; Merkel, H.; Michel, M.; Mora Espi, M. C.; Müller, U.; Pochodzalla, J.; Sanchez, S.; Sanchez-Lorente, A.; Schlimme, S.; Sfienti, C.; Thiel, M.; Weber, T.; Dormenev, V. I.; Fedorov, A. A.; Korzhik, M. V.; Missevitch, O. V.; Balanutsa, V.; Chernetsky, V.; Demekhin, A.; Dolgolenko, A.; Fedorets, P.; Gerasimov, A.; Goryachev, V.; Varentsov, V.; Boukharov, A.; Malyshev, O.; Marishev, I.; Semenov, A.; Böhmer, F.; Dørheim, S.; Ketzer, B.; Paul, S.; Hergemöller, A. K.; Khoukaz, A.; Köhler, E.; Täschner, A.; Wessels, J.; Varma, R.; Chaterjee, A.; Jha, V.; Kailas, S.; Roy, B. J.; Yan, Y.; Chinorat, K.; Khanchai, K.; Ayut, L.; Pomrad, S.; Baldin, E.; Kotov, K.; Peleganchuk, S.; Tikhonov, Yu.; Boucher, J.; Chambert, V.; Dbeyssi, A.; Gumberidze, M.; Hennino, T.; Imre, M.; Kunne, R.; Le Galliard, C.; Ma, B.; Marchand, D.; Maroni, A.; Ong, S.; Ramstein, B.; Rosier, P.; Tomasi-Gustafsson, E.; Van de Wiele, J.; Boca, G.; Braghieri, A.; Costanza, S.; Genova, P.; Lavezzi, L.; Montagna, P.; Rotondi, A.; Abramov, V.; Belikov, N.; Davidenko, A.; Derevschikov, A.; Goncharenko, Y.; Grishin, V.; Kachanov, V.; Konstantinov, D.; Kormilitsin, V.; Melnik, Y.; Levin, A.; Minaev, N.; Mochalov, V.; Morozov, D.; Nogach, L.; Poslavskiy, S.; Ryazantsev, A.; Ryzhikov, S.; Semenov, P.; Shein, I.; Uzunian, A.; Vasiliev, A.; Yakutin, A.; Bäck, T.; Cederwall, B.; Makónyi, K.; Tegnér, P. E.; von Würtemberg, K. M.; Belostotski, S.; Gavrilov, G.; Itzotov, A.; Kashchuk, A.; Kisselev, A.; Kravchenko, P.; Levitskaya, O.; Manaenkov, S.; Miklukho, O.; Naryshkin, Y.; Veretennikov, D.; Vikhrov, V.; Zhadanov, A.; Alberto, D.; Amoroso, A.; Bussa, M. P.; Busso, L.; De Mori, F.; Destefanis, M.; Fava, L.; Ferrero, L.; Greco, M.; Maggiora, M.; Marcello, S.; Sosio, S.; Spataro, S.; Zotti, L.; Calvo, D.; Coli, S.; De Remigis, P.; Filippi, A.; Giraudo, G.; Lusso, S.; Mazza, G.; Morra, O.; Rivetti, A.; Wheadon, R.; Iazzi, F.; Lavagno, A.; Younis, H.; Birsa, R.; Bradamante, F.; Bressan, A.; Martin, A.; Clement, H.; Galander, B.; Caldeira Balkeståhl, L.; Calén, H.; Fransson, K.; Johansson, T.; Kupsc, A.; Marciniewski, P.; Thomé, E.; Wolke, M.; Zlomanczuk, J.; Díaz, J.; Ortiz, A.; Dmowski, K.; Duda, P.; Korzeniewski, R.; Slowinski, B.; Chlopik, A.; Guzik, Z.; Kosinski, K.; Melnychuk, D.; Wasilewski, A.; Wojciechowski, M.; Wronka, S.; Wysocka, A.; Zwieglinski, B.; Bühler, P.; Hartman, O. N.; Kienle, P.; Marton, J.; Suzuki, K.; Widmann, E.; Zmeskal, J.

    2013-02-01

    This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the overline{P}ANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole overline{P}ANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described.

  9. A systematic study of the strong interaction with P-barANDA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Messchendorp, J. G.

    2011-10-21

    The theory of Quantum Chromo Dynamics (QCD) reproduces the strong interaction at distances much shorter than the size of the nucleon. At larger distance scales, the generation of hadron masses and confinement cannot yet be derived from first principles on basis of QCD. The PANDA experiment at FAIR will address the origin of these phenomena in controlled environments. Beams of antiprotons together with a multi-purpose and compact detection system will provide unique tools to perform studies of the strong interaction. This will be achieved via precision spectroscopy of charmonium and open-charm states, an extensive search for exotic objects such asmore » glueballs and hybrids, in-medium and hypernuclei spectroscopy, and more. An overview is given of the physics program of the P-barANDA collaboration.« less

  10. Online Tracking Algorithms on GPUs for the P̅ANDA Experiment at FAIR

    NASA Astrophysics Data System (ADS)

    Bianchi, L.; Herten, A.; Ritman, J.; Stockmanns, T.; Adinetz, A.; Kraus, J.; Pleiter, D.

    2015-12-01

    P̅ANDA is a future hadron and nuclear physics experiment at the FAIR facility in construction in Darmstadt, Germany. In contrast to the majority of current experiments, PANDA's strategy for data acquisition is based on event reconstruction from free-streaming data, performed in real time entirely by software algorithms using global detector information. This paper reports the status of the development of algorithms for the reconstruction of charged particle tracks, optimized online data processing applications, using General-Purpose Graphic Processing Units (GPU). Two algorithms for trackfinding, the Triplet Finder and the Circle Hough, are described, and details of their GPU implementations are highlighted. Average track reconstruction times of less than 100 ns are obtained running the Triplet Finder on state-of- the-art GPU cards. In addition, a proof-of-concept system for the dispatch of data to tracking algorithms using Message Queues is presented.

  11. Charm Production in Interactions of Antiproton with Proton and Nuclei at \\bar{it{P}}it{ANDA} Energies

    NASA Astrophysics Data System (ADS)

    Shyam, R.; Tsushima, K.

    2018-05-01

    We study the production of charmed baryons in the antiproton-proton and antiproton-nucleus interactions within a fully covariant model that is based on an effective Lagrangian approach. The baryon production proceeds via the t-channel D^0 and D^{*0} meson-exchange diagrams. We have also explored the production of the charm-baryon hypernucleus ^{16}_{Λ_c^+}O in the antiproton-^{16}O collisions. For antiproton beam momenta of interest to the {\\bar{P}}ANDA experiment, the 0° differential cross sections for the formation of ^{16}_{Λ_c^+}O hypernuclear states with simple particle-hole configurations, have magnitudes in the range of a few μ b/sr.

  12. Feasibility studies of time-like proton electromagnetic form factors at $$\\overline{\\rm P}$$ANDA at FAIR

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Singh, B.; Erni, W.; Krusche, B.

    Simulation results for future measurements of electromagnetic proton form factors atmore » $$\\overline{\\rm P}$$ANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel p¯p → e +e – is studied on the basis of two different but consistent procedures. The suppression of the main background channel, i.e. p¯p → π +π –, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. Furthermore, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance.« less

  13. Feasibility studies of time-like proton electromagnetic form factors at $$\\overline{\\rm P}$$ANDA at FAIR

    DOE PAGES

    Singh, B.; Erni, W.; Krusche, B.; ...

    2016-10-28

    Simulation results for future measurements of electromagnetic proton form factors atmore » $$\\overline{\\rm P}$$ANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel p¯p → e +e – is studied on the basis of two different but consistent procedures. The suppression of the main background channel, i.e. p¯p → π +π –, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. Furthermore, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance.« less

  14. The Coastal Carbonate Chemistry in Bolinao-Anda, Pangasinan, Northern Philippines

    NASA Astrophysics Data System (ADS)

    Lagumen, M. C. T.; San Diego-McGlone, M. L.; Araujo, M.; Noriega, C.

    2016-12-01

    The coastal ocean represents only 7% of the total ocean area, but the interactions of CO2 (dissolved, atmospheric) within the coastal area is very dynamic. This study was conducted in the coastal waters of the Bolinao-Anda channel, Pangasinan, Philippines. The 28 stations were divided into 3 groups: coral, seagrass and mariculture area. Samples were collected for carbonate parameters namely total alkalinity (TA), dissolved inorganic carbon (DIC) and pH. Air-sea surface CO2 flux (FCO2) was estimated from the difference between partial pressure of CO2 at sea surface (pCO2) and the concentration of CO2 in the atmosphere (pCO2atm). TA ranged from 1226 to 2240 µmol/kg with highest value in the seagrass stations and lowest in the mariculture stations. Mean TA in coral and seagrass stations were similar at 2104.11 ± 6.54 µmol/kg and 2093.32 ± 62.67 µmol/kg, respectively. DIC ranged from 1270.12 µmol/kg to 2006.26 µmol/kg. Mean DIC values were 1868.12 ± 20.25 µmol/kg for coral stations, 1776.82 ± 87.87 µmol/kg for seagrass stations, and 1715.94 ± 52.61 µmol/kg for mariculture stations. A higher range of pH (7.95 to 8.52) and Ωarg (1.97 to 4.85) were determined for the coral and seagrass stations compared to mariculture stations. Mean pH value in mariculture stations was 7.60 ± 0.04, while the mean pH of coral stations was 8.05 ± 0.03, and seagrass stations was 8.27 ± 0.09. The mariculture area is a source of CO2 with flux of 44.72 mmol m-2 day-1 and the coral area too athough flux is small at 0.31 mmol m-2 day-1, while the seagrass area is a sink for CO2 with mean flux of -5.91 mmol m-2 day-1. It is likely that water quality conditions due to mariculture can affect the corals and seagrass areas due to the hydrodynamics of the area.

  15. 76 FR 33310 - Bristol-Myers Squibb Co. et al.; Withdrawal of Approval of 70 New Drug Applications and 97...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ..., Inc. ANDA 074634 Dobutamine Injection Hospira, Inc. USP, 12.5 mg/mL. ANDA 074643 Minoxidil Topical Bausch & Lomb, Inc. Solution, 2%. ANDA 074743 Minoxidil Topical Sight Solution, 2%. Pharmaceuticals, Inc...

  16. PANDA Muon System Prototype

    NASA Astrophysics Data System (ADS)

    Abazov, Victor; Alexeev, Gennady; Alexeev, Maxim; Frolov, Vladimir; Golovanov, Georgy; Kutuzov, Sergey; Piskun, Alexei; Samartsev, Alexander; Tokmenin, Valeri; Verkheev, Alexander; Vertogradov, Leonid; Zhuravlev, Nikolai

    2018-04-01

    The PANDA Experiment will be one of the key experiments at the Facility for Antiproton and Ion Research (FAIR) which is under construction now in the territory of the GSI Helmholtz Centre for Heavy Ion Research in Darmstadt, Germany. PANDA is aimed to study hadron spectroscopy and various topics of the weak and strong forces. Muon System is chosen as the most suitable technology for detecting the muons. The Prototype of the PANDA Muon System is installed on the test beam line T9 at the Proton Synchrotron (PS) at CERN. Status of the PANDA Muon System prototype is presented with few preliminary results.

  17. 77 FR 16039 - Abbott Laboratories et al.; Withdrawal of Approval of 35 New Drug Applications and 64 Abbreviated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... Do. nitroprusside for Injection USP), 50 mg. ANDA 071015 Haloperidol Oral Teva Pharmaceuticals... 075065 Acyclovir Sodium for Do. Injection. ANDA 075176 Haloperidol Do. Decanoate Injection, 50 mg/mL and...

  18. Common Filing Deficiencies in Abbreviated New Drug Applications Containing Clinical Endpoint Studies.

    PubMed

    Fermaglich, Lewis J; Chen, Ru; Kim, Carol Y; Chuh, Eunjung Esther; Thomas, Teena; Shetty, Daiva; Lee, Julia; Young, Johnny; Fan, Ying

    2018-01-01

    The objective of this report is to summarize common deficiencies identified in the filing reviews of abbreviated new drug applications (ANDAs) with clinical endpoint bioequivalence studies and skin irritation, sensitization, and adhesion (I/S/A) studies received by the US Food and Drug Administration (FDA) between 2007 and 2017, to help applicants avoid common deficiencies, minimize "refuse-to-receive" (RTR) actions, "information requests," and ANDA approval delays. Multiple internal FDA databases were searched to evaluate and summarize common deficiencies identified in ANDA submissions containing clinical endpoint studies and skin I/S/A studies that required review by the Division of Clinical Review. A total of 275 ANDA submissions with filing reviews from January 2007 to June 2017 were analyzed in this report. Two hundred eighteen (79.3%) filing reviews contained one or more deficiencies. Seventy-nine (28.7%) ANDAs were issued RTR letters because of major clinical deficiencies, specifically bioequivalence and clinical deficiencies, accounting for 9% of overall identified deficiencies. Twenty-two other categories of deficiencies are summarized into 4 main categories: missing information related to the clinical studies other than data sets (38%), missing data sets (35%), formulation issues (12%), and organization/format issues (6%). The most common deficiency in the "missing information related to the clinical studies other than data sets" category was "missing clarification of information" (22%). We also noted that the Division of Filing Review has identified these same types of deficiencies since assuming responsibility of the filing assessment for ANDAs with clinical endpoint BE studies and skin I/S/A studies. In conclusion, to minimize "refuse-to-receive" actions, "information requests," and approval of ANDA delays for generic drug products, applicants should submit full clinical study reports, including all data sets for drug products recommending clinical

  19. 76 FR 82302 - Determination That HYCODAN (Hydrocodone Bitartrate and Homatropine Methylbromide) Tablets, 5...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to HYCODAN... Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... effectiveness. This determination will allow FDA to approve abbreviated new drug applications (ANDAs) for...

  20. 76 FR 20357 - Determination That KEFLEX (Cephalexin) Capsule, Equivalent to 333 Milligrams Base, Was Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to KEFLEX... for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice... effectiveness. This determination will allow FDA to approve abbreviated new drug applications (ANDAs) for...

  1. 76 FR 44012 - Determination That NUVIGIL (Armodafinil) Tablets, 100 Milligrams and 200 Milligrams, Were Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... Milligrams, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... effectiveness. This determination will allow FDA to approve abbreviated new drug applications (ANDAs) for... the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the listed...

  2. Completeness assessment of type II active pharmaceutical ingredient drug master files under generic drug user fee amendment: review metrics and common incomplete items.

    PubMed

    Zhang, Huyi; Li, Haitao; Song, Wei; Shen, Diandian; Skanchy, David; Shen, Kun; Lionberger, Robert A; Rosencrance, Susan M; Yu, Lawrence X

    2014-09-01

    Under the Generic Drug User Fee Amendments (GDUFA) of 2012, Type II active pharmaceutical ingredient (API) drug master files (DMFs) must pay a user fee and pass a Completeness Assessment (CA) before they can be referenced in an Abbreviated New Drug Application (ANDA), ANDA amendment, or ANDA prior approval supplement (PAS). During the first year of GDUFA implementation, from October 1, 2012 to September 30, 2013, approximately 1,500 Type II API DMFs received at least one cycle of CA review and more than 1,100 Type II DMFs were deemed complete and published on FDA's "Available for Reference List". The data from CA reviews were analyzed for factors that influenced the CA review process and metrics, as well as the areas of DMF submissions which most frequently led to an incomplete CA status. The metrics analysis revealed that electronic DMFs appear to improve the completeness of submission and shorten both the review and response times. Utilizing the CA checklist to compile and proactively update the DMFs improves the chance for the DMFs to pass the CA in the first cycle. However, given that the majority of DMFs require at least two cycles of CA before being deemed complete, it is recommended that DMF fees are paid 6 months in advance of the ANDA submissions in order to avoid negatively impacting the filling status of the ANDAs.

  3. Fully transparent, non-volatile bipolar resistive memory based on flexible copolyimide films

    NASA Astrophysics Data System (ADS)

    Yu, Hwan-Chul; Kim, Moon Young; Hong, Minki; Nam, Kiyong; Choi, Ju-Young; Lee, Kwang-Hun; Baeck, Kyoung Koo; Kim, Kyoung-Kook; Cho, Soohaeng; Chung, Chan-Moon

    2017-01-01

    Partially aliphatic homopolyimides and copolyimides were prepared from rel-(1'R,3S,5'S)-spiro[furan-3(2H),6'-[3]oxabicyclo[3.2.1]octane]-2,2',4',5(4H)-tetrone (DAn), 2,6-diaminoanthracene (AnDA), and 4,4'-oxydianiline (ODA) by varying the molar ratio of AnDA and ODA. We utilized these polyimide films as the resistive switching layer in transparent memory devices. While WORM memory behavior was obtained with the PI-A100-O0-based device (molar feed ratio of DAn : AnDA : ODA = 1 : 1 : 0), the PI-A70-O30-based device (molar feed ratio of DAn : AnDA : ODA = 1 : 0.7 : 0.3) exhibited bipolar resistive switching behavior with stable retention for 104 s. This result implies that the memory properties can be controlled by changing the polyimide composition. The two devices prepared from PI-A100-O0 and PI-A70-O30 showed over 90% transmittance in the visible wavelength range from 400 to 800 nm. The behavior of the memory devices is considered to be governed by trap-controlled, space-charge limited conduction (SCLC) and local filament formation. [Figure not available: see fulltext.

  4. 78 FR 47321 - Determination That CYTOXAN (Cyclophosphamide) for Injection Was Not Withdrawn From Sale for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ..., Hodgkin's disease, lymphocytic lymphoma, mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's... marketing for reasons other than safety or effectiveness. ANDAs that refer to CYTOXAN (cyclophosphamide) for...

  5. 75 FR 10865 - Shoreline Management Initiative, Reservoirs in Alabama, Georgia, Kentucky, Mississippi, North...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... shoreline management zones, management of access/ view corridor size, use of best management practices for...: February 25, 2010. Anda Ray, Senior Vice President of Environment and Technology and Environmental...

  6. 78 FR 40484 - Determination That METADATE ER (Methylphenidate Hydrochloride) Extended-Release Tablet, 10...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ..., educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the... marketing for reasons other than safety or effectiveness. ANDAs that refer to METADATE ER (methylphenidate...

  7. 75 FR 48742 - Renewal of the Regional Resource Stewardship Council Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... its natural resource stewardship activities through a balanced and broad range of diverse views and... for public input regarding stewardship issues. Dated: July 26, 2010. Anda A. Ray, Senior Vice...

  8. 77 FR 43337 - Drugs for Human Use; Drug Efficacy Study Implementation; Certain Prescription Drugs Offered for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    .... (now part of Kremers-Urban Pharmaceuticals, Inc., 902 Carnegie Center, Suite 360, Princeton, NJ 08540...-687) and Spasmolin (ANDA 86-655); Sandoz, Inc., 506 Carnegie Center, Suite 400, Princeton, NJ 08540...

  9. Writing Center Administration and/as Emotional Labor

    ERIC Educational Resources Information Center

    Jackson, Rebecca; McKinney, Jackie Grutsch; Caswell, Nicole I.

    2016-01-01

    Scholars have offered research and theory about emotional labor and the feeling of emotion in rhetoric and composition, but we have little if any such research on writing center work specifically. Drawing on data from a year-long qualitative study of writing center directors' labor, this article examines writing center directors' emotional labor…

  10. 76 FR 32258 - Meeting of the Regional Resource Stewardship Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... Discussion and Advice. The RRSC will hear opinions and views of citizens by providing a public comment..., Knoxville, Tennessee 37902, (865) 632-6113. Dated: May 25, 2011. Anda A. Ray, Senior Vice President and...

  11. 78 FR 73200 - Draft Guidance for Industry on Bioequivalence Recommendations for Paliperidone Palmitate Extended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... Paliperidone Palmitate Extended-Release Injectable Suspension; Availability AGENCY: Food and Drug...) studies to support abbreviated new drug applications (ANDAs) for paliperidone palmitate extended-release... the availability of revised draft BE recommendations for paliperidone palmitate extended-release...

  12. 78 FR 63228 - Determination That Potassium Citrate, 10 Milliequivalents/Packet and 20 Milliequivalents/Packet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... approved. ANDA applicants do not have to repeat the extensive clinical testing otherwise necessary to gain... mEq/packet and 20 mEq/packet, is the subject of NDA 19-647, held by Nova-K LLC, and initially...

  13. 77 FR 58399 - Draft Guidance for Industry on Bioequivalence Recommendations for Pentosan Polysulfate Sodium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... Polysulfate Sodium Capsule; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... entitled ``Bioequivalence Recommendations for Pentosan Polysulfate Sodium.'' The recommendations provide... (ANDAs) for pentosan polysulfate sodium capsule. DATES: Although you can comment on any guidance at any...

  14. 76 FR 53907 - Determination That TALWIN COMPOUND (Aspirin; Pentazocine Hydrochloride) Tablets, 325 Milligrams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ...] Determination That TALWIN COMPOUND (Aspirin; Pentazocine Hydrochloride) Tablets, 325 Milligrams; Equivalent to... determined that TALWIN COMPOUND (aspirin; pentazocine hydrochloride (HCl)) tablets, 325 milligrams (mg... determination will allow FDA to approve abbreviated new drug applications (ANDAs) for aspirin; pentazocine HCl...

  15. 78 FR 16685 - Impax Laboratories, Inc.; Withdrawal of Approval of Bupropion Hydrochloride Extended-Release...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ...] Impax Laboratories, Inc.; Withdrawal of Approval of Bupropion Hydrochloride Extended-Release Tablets... Administration (FDA) is withdrawing approval of Bupropion Hydrochloride (HCl) Extended-Release Tablets, 300 Milligrams (mg) (Bupropion HCl Extended-Release Tablets 300 mg), under Abbreviated New Drug Application (ANDA...

  16. MOAtox: A Comprehensive Mode of Action and Acute Aquatic Toxicity Database for Predictive Model Development

    EPA Science Inventory

    tThe mode of toxic action (MOA) has been recognized as a key determinant of chemical toxicity andas an alternative to chemical class-based predictive toxicity modeling. However, the development ofquantitative structure activity relationship (QSAR) and other models has been limite...

  17. 77 FR 56851 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... draft product-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal...

  18. 78 FR 52777 - Draft Guidance for Industry on Bioequivalence Recommendations for Risperidone Injection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ...] (Formerly Docket No. 2007D-0168) Draft Guidance for Industry on Bioequivalence Recommendations for... industry entitled ``Draft Guidance on Risperidone.'' The guidance provides specific recommendations on the design of bioequivalence (BE) studies to support abbreviated new drug applications (ANDAs) for...

  19. 77 FR 18827 - Draft Guidance for Industry on Bioequivalence Recommendations for Iron Sucrose Injection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ...] Draft Guidance for Industry on Bioequivalence Recommendations for Iron Sucrose Injection; Availability... Recommendations for Iron Sucrose.'' The recommendations provide specific guidance on the design of bioequivalence (BE) studies to support abbreviated new drug applications (ANDAs) for iron sucrose injection. DATES...

  20. "Not Censorship but Selection": Censorship and/as Prizing

    ERIC Educational Resources Information Center

    Kidd, Kenneth

    2009-01-01

    This essay calls for a fresh critical approach to the topic of censorship, suggesting that anticensorship efforts, while important and necessary, function much like literary prizing. The analysis draws especially on James English's recent study "The Economy of Prestige." There are two central arguments: first, that the librarian ethic of…

  1. 77 FR 7585 - Draft Guidance for Industry on Bioequivalence Recommendations for Rifaximin Tablets; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... (rifaximin-550). The recommendations provide specific guidance on the design of bioequivalence (BE) studies... studies to support ANDAs for rifaximin-200 (Draft Rifaximin-200 BE Recommendations). FDA is now issuing a...] Draft Guidance for Industry on Bioequivalence Recommendations for Rifaximin Tablets; Availability AGENCY...

  2. 78 FR 20925 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

  3. 77 FR 35688 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

  4. 77 FR 16842 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... Recommendations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...-specific bioequivalence (BE) recommendations. The recommendations provide product-specific guidance on the design of BE studies to support abbreviated new drug applications (ANDAs). In the Federal Register of...

  5. A Randomized Clinical Trial of Allopregnanolone for the Treatment of Severe Traumatic Brain Injury

    DTIC Science & Technology

    2012-10-01

    product, including assay, impurity/degradant levels, sterility results, pyrogenicity results, pH, 6 osmolality and particulates; stability data and...as a function of Glasgow Outcome Score. J Clin Exp Neuropsychol 20:270-279. Rogawski MA, Reddy DS (2004) Neurosteroids: Endogenous modulators of

  6. 78 FR 63227 - Determination That INTAL (cromolyn sodium) Inhalation Capsule, 20 Milligrams, Was Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ...] Determination That INTAL (cromolyn sodium) Inhalation Capsule, 20 Milligrams, Was Not Withdrawn From Sale for... Food and Drug Administration (FDA) has determined that INTAL (cromolyn sodium) Inhalation Capsule, 20... allow FDA to approve abbreviated new drug applications (ANDAs) for cromolyn sodium inhalation capsule...

  7. Solid Layer Thermal-conductivity Measurement Techniques

    DTIC Science & Technology

    1994-03-01

    deposited on the sample, and the absorption of laser radiation. Temperature-measurement tools include thermocouples, infrared (IR) pyrometers , and...A, Nishimura H, and Sawada T (1990), Laser-Induc~d Surface Acoustic Waves and Photothc:rmal Surfitce Gratings Generated by Crossing Two Pulsed

  8. 76 FR 3144 - Draft Guidance for Industry on Size of Beads in Drug Products Labeled for Sprinkle; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... can be sprinkled on soft foods and swallowed without chewing as an alternative administration... parameters are considered in this draft guidance as they relate to drug products labeled for sprinkle: (1... size differences between reference listed drugs and ANDAs and meet bioavailability (BA) or...

  9. 76 FR 54473 - Guidance on Positron Emission Tomography Drug Applications-Content and Format for New Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... (formerly Docket No. 00D-0892)] Guidance on Positron Emission Tomography Drug Applications-- Content and... the availability of a guidance for industry entitled ``PET Drug Applications--Content and Format for... guidance for industry entitled ``PET Drug Applications--Content and Format for NDAs and ANDAs.'' The...

  10. 76 FR 19997 - Determination That FENTORA (Fentanyl Citrate) Buccal Tablet, 300 Micrograms, Was Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ...] Determination That FENTORA (Fentanyl Citrate) Buccal Tablet, 300 Micrograms, Was Not Withdrawn From Sale for... Food and Drug Administration (FDA) has determined that FENTORA (fentanyl citrate) buccal tablet, 300... allow FDA to approve abbreviated new drug applications (ANDAs) for fentanyl citrate buccal tablet, 300...

  11. Dynamic Information Networks: Geometry, Topology and Statistical Learning for the Articulation of Structure

    DTIC Science & Technology

    2015-06-23

    T. Bates, S. Brocklebank, S. Pauls, and D.Rockmore, A spectral clustering approach to the structure of personality: contrasting the FFM and...A spectral clustering approach to the structure of personality: contrasting the FFM and HEXACO models, Journal of Research in Personality, Volume 57

  12. 75 FR 33311 - Guidance for Industry on Bioequivalence Recommendations for Specific Products; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... available recommendations on how to design product- specific bioequivalence (BE) studies to support... meaningful opportunity for the public to consider and comment on product-specific BE study recommendations... available recommendations on how to design product-specific BE studies to support ANDAs. Under this process...

  13. 75 FR 10805 - Determination That DOVONEX (Calcipotriene) Ointment, 0.005%, Was Not Withdrawn From Sale for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... marketing for reasons other than safety or effectiveness. ANDAs that refer to DOVONEX (calcipotriene... From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION... (calcipotriene) Ointment, 0.005%, was not withdrawn from sale for reasons of safety or effectiveness. This...

  14. 76 FR 11487 - Determination That NILSTAT (Nystatin Powder (Oral, 100%)) Was Not Withdrawn From Sale for Reasons...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... that have been discontinued from marketing for reasons other than safety or effectiveness. ANDAs that... Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... reasons of safety or effectiveness. This determination will allow FDA to approve abbreviated new drug...

  15. 78 FR 6823 - Determination That DIFFERIN (Adapalene) Solution, 0.1%, Was Not Withdrawn From Sale for Reasons...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to DIFFERIN... Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... sale for reasons of safety or effectiveness. This determination will allow FDA to approve abbreviated...

  16. 77 FR 23269 - Determination That FUNDUSCEIN-25 (fluorescein sodium injection), 25%, and AK-FLUOR (fluorescein...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ...] Determination That FUNDUSCEIN-25 (fluorescein sodium injection), 25%, and AK-FLUOR (fluorescein sodium injection... FUNDUSCEIN-25 (fluorescein sodium injection), 25%, and AK-FLUOR (fluorescein sodium injection), 25%, were not... abbreviated new drug applications (ANDAs) for fluorescein sodium injection, 25%, if all other legal and...

  17. Mechanoelectrically Activated Synthesis of Dense, Bulk Nanostructured, Complex Crystalline and Glassy Hard Materials

    DTIC Science & Technology

    2005-04-01

    Facultad de Quimica , Universidad Autonoma de Queretaro, Queretaro, Mexico, May 7, 2002. (Invited Seminar) "* Recent Advances in the Synthesis and...A. Munir, 14o Congresso Brasileiro de Engenharia e Ciencias dos Materiais (14th Brazilian Congress on Materials Science and Engineering), Sao Pedro

  18. Identification of Risk Factors for Exertional Heat Illness: A Brief Commentary on Genetic Testing

    DTIC Science & Technology

    2007-01-01

    RYR1) gene and other genes related to disorders of skeletal muscle. Data Synthesis : EHI is a complex disorder wherein physiological, environmental, and...a life-threatening, hypermetabolic syndrome, known as a fulminant MH episode; similar (rare) events can be induced by high environmental temperatures

  19. 75 FR 55796 - Determination That VESANOID (Tretinoin) Capsules, 10 Milligrams, Were Not Withdrawn From Sale for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ...] Determination That VESANOID (Tretinoin) Capsules, 10 Milligrams, Were Not Withdrawn From Sale for Reasons of... Drug Administration (FDA) has determined that VESANOID (tretinoin) Capsules, 10 milligrams (mg), were... approved. FDA may not approve an ANDA that does not refer to a listed drug. VESANOID (tretinoin) Capsules...

  20. 78 FR 52931 - Draft Guidance for Industry on Abbreviated New Drug Applications: Stability Testing of Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-D-0938] Draft Guidance for Industry on Abbreviated New Drug Applications: Stability Testing of Drug Substances... Products, Questions and Answers.'' Because of increases in the number and complexity of ANDAs and FDA's...

  1. 78 FR 37231 - Guidance for Industry; Guidance on Abbreviated New Drug Applications: Stability Testing of Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-D-0938] Guidance for Industry; Guidance on Abbreviated New Drug Applications: Stability Testing of Drug Substances....'' Because of increases in the number and complexity of ANDAs and FDA's desire to standardize generic drug...

  2. 78 FR 35038 - Determination That CORDRAN (Flurandrenolide) Ointment USP, 0.025% and 0.05%, Were Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... been discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to... Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The...% and 0.05%, were not withdrawn from sale for reasons of safety or effectiveness. This determination...

  3. 75 FR 69088 - Determination That Amphetamine Sulfate, 5 and 10 Milligram Tablets, Was Not Withdrawn From Sale...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... products that have been discontinued from marketing for reasons other than safety or effectiveness. ANDAs... Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... not withdrawn from sale for reasons of safety or effectiveness. This determination will allow FDA to...

  4. 77 FR 7583 - Determination That WILPO (phentermine hydrochloride) Tablets, 8 Milligrams, Was Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to WILPO... Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The... Milligrams (mg), was not withdrawn from sale for reasons of safety or effectiveness. This determination will...

  5. 75 FR 51080 - Determination That DIASTAT (Diazepam Rectal Gel), 5 Milligrams/Milliliter, 10 Milligrams/2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... effectiveness. This determination will allow FDA to approve abbreviated new drug applications (ANDAs) for... effectiveness, or if FDA determines that the listed drug was withdrawn from sale for reasons of safety or...

  6. 77 FR 25720 - Determination That GRIFULVIN V (Griseofulvin Microcrystalline) Tablets, 250 Milligrams, Was Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... been discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to... Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice... microcrystalline) tablets, 250 milligrams (mg), was not withdrawn from sale for reasons of safety or effectiveness...

  7. 76 FR 75886 - Determination That DEMULEN 1/50-28 (Ethinyl Estradiol; Ethynodiol Diacetate) Tablet and Four...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... marketing for reasons other than safety or effectiveness. Approved ANDAs that refer to the NDAs listed in... Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... effectiveness. This determination means that FDA will not begin procedures to withdraw approval of abbreviated...

  8. 76 FR 28045 - Determination That XIBROM (Bromfenac Ophthalmic Solution) 0.09% Was Not Withdrawn From Sale for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... marketing for reasons other than safety or effectiveness. ANDAs that refer to XIBROM (bromfenac ophthalmic... Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... withdrawn from sale for reasons of safety or effectiveness. This determination will allow FDA to approve...

  9. 78 FR 63228 - Determination That PARAFLEX (Chlorzoxazone) Tablets, 250 Milligrams, Was Not Withdrawn From Sale...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... products that have been discontinued from marketing for reasons other than safety or effectiveness. ANDAs... Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...), was not withdrawn from sale for reasons of safety or effectiveness. This determination will allow FDA...

  10. 75 FR 11549 - Determination That PRO-BANTHINE (Propantheline Bromide) Tablets and 14 Other Drug Products Were...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... marketing for reasons other than safety or effectiveness. Approved ANDAs that refer to the NDAs listed in... From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION... in this document were not withdrawn from sale for reasons of safety or effectiveness. This...

  11. 77 FR 53892 - Determination That ALOXI (Palonosetron Hydrochloride) Capsules, 0.5 Milligram (Base), Were Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... discontinued from marketing for reasons other than safety or effectiveness. ANDAs that refer to ALOXI... Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice...)) Capsules, 0.5 milligram (mg) (base), were not withdrawn from sale for reasons of safety or effectiveness...

  12. 77 FR 16036 - Determination That CITANEST (Prilocaine Hydrochloride) Injection, 1%, 2%, and 3%, and CITANEST...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... marketing for reasons other than safety or effectiveness. ANDAs that refer to CITANEST (prilocaine HCl... Hydrochloride) Injection, 4%, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food... (prilocaine HCl) Injection, 4%, were not withdrawn from sale for reasons of safety or effectiveness. This...

  13. 77 FR 14810 - Determination That DURANEST (Etidocaine Hydrochloride) Injection, 0.5%, and Five Other DURANEST...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... marketing for reasons other than safety or effectiveness. ANDAs that refer to any of the DURANEST drug... Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... reasons of safety or effectiveness. This determination will allow FDA to approve abbreviated new drug...

  14. 77 FR 7586 - Draft Guidance for Industry on Bioequivalence Recommendation for Nitroglycerin Metered Spray...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... though we have not requested comparative in vitro studies, in vitro studies outlined in the 2002 guidance.... The recommendations provide specific guidance on the design of bioequivalence (BE) studies to support... draft guidance for industry on the Agency's recommendations for BE studies to support ANDAs for...

  15. Doctrine Development Process in the Kenya Army: Bridging the Gap

    DTIC Science & Technology

    2014-06-13

    concepts, and principles . It must broadly follow three doctrine development phases: the collection/information gathering phase; the formulation and...a capable lead organization. The organization must eliminate terminological and utility confusion among doctrine, concepts, and principles . It must...15 The relationship Between Military Doctrine, Concept and Principle

  16. Probes, Surveys, and the Ontology of the Social

    ERIC Educational Resources Information Center

    Collins, Harry; Evans, Robert

    2017-01-01

    By distinguishing between a survey and--a newly introduced term--a "probe," we recast the relationship between qualitative and quantitative approaches to social science. The difference turns on the "uniformity" of the phenomenon being examined. Uniformity is a fundamental idea underlying all scientific research but is rarely…

  17. 78 FR 38053 - Determination That OPANA ER (Oxymorphone Hydrochloride) Drug Products Covered by New Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ...] Determination That OPANA ER (Oxymorphone Hydrochloride) Drug Products Covered by New Drug Application 21-610... (oxymorphone hydrochloride (HCl)) Extended-Release Tablet products approved under new drug application (NDA) 21... refer to these drug products, and it will allow FDA to continue to approve ANDAs for oxymorphone HCl...

  18. 76 FR 12916 - Benzocaine; Weight Control Drug Products for Over-the-Counter Human Use

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... endpoint. Reports purporting to be two studies by Collipp (one published and one unpublished) were..., OTC weight control drug products containing benzocaine will require an approved NDA or ANDA. Studies...., a manufacturer of OTC weight control drug products, submitted two citizen petitions, one in 1990 and...

  19. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale.... SUMMARY: The Food and Drug Administration (FDA) has determined that REV-EYES (dapiprazole hydrochloride... CFR 314.161)). FDA may not approve an ANDA that does not refer to a listed drug. REV-EYES (dapiprazole...

  20. RNAi mediated, stable resistance to Triticum mosaic virus in wheat

    USDA-ARS?s Scientific Manuscript database

    Triticum mosaic virus (TriMV), discovered in 2006, affects wheat production systems in the Great Plains of the United States. There are no available TriMV resistant commercial varieties. RNA interference (RNAi) was evaluated as an alternative strategy to generate resistance to TriMV. An RNAi pANDA...

  1. 77 FR 29665 - Determination That PITRESSIN TANNATE IN OIL (Vasopressin Tannate) Injection, 5 Pressor Units...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION... safety or effectiveness. This determination will allow FDA to approve abbreviated new drug applications... suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines...

  2. 77 FR 35985 - Determination That PARAPLATIN (Carboplatin) Injection and SUSTIVA (Efavirenz) Capsules Were Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice... document were not withdrawn from sale for reasons of safety or effectiveness. This determination means that... the drug's NDA or ANDA for reasons of safety or effectiveness, or if FDA determines that the listed...

  3. 75 FR 64310 - Determination That BUSPAR (Buspirone Hydrochloride) Tablets, 10 Milligrams, 15 Milligrams, and 30...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ..., Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... reasons of safety or effectiveness. This determination means that FDA will not begin procedures to... withdraws or suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA...

  4. 75 FR 14444 - Determination That DIDREX (Benzphetamine Hydrochloride) Tablets, 25 Milligrams, Were Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Milligrams, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... safety or effectiveness. This determination will allow FDA to approve abbreviated new drug applications... or suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA...

  5. 76 FR 9789 - Determination That Theophylline Oral Solution, 80 Milligrams/15 Milliliters, Was Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The...)/15 milliliters (mL), was not withdrawn from sale for reasons of safety or effectiveness. This... the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the listed...

  6. 75 FR 61503 - Determination That AZDONE (Hydrocodone Bitartrate and Aspirin) Tablet, 5 Milligrams/500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ...] Determination That AZDONE (Hydrocodone Bitartrate and Aspirin) Tablet, 5 Milligrams/500 Milligrams, Was Not... bitartrate and aspirin) Tablet, 5 milligrams (mg)/ 500 mg, was not withdrawn from sale for reasons of safety... (ANDAs) for hydrocodone bitartrate and aspirin tablet, 5 mg/500 mg, if all other legal and regulatory...

  7. Economic Impacts of the Generic Drug User Fee Act Fee Structure.

    PubMed

    Dong, Ke; Boehm, Garth; Zheng, Qiang

    2017-06-01

    A Food and Drug Administration (FDA) Generic Drug User system, Generic Drug User Fee Amendment of 2012 (GDUFA), started October 1, 2012, and has been in place for over 3 years. There is controversy about the GDUFA fee structure but no analysis of GDUFA data that we could find. To look at the economic impact of the GDUFA fee structure. We compared the structure of GDUFA with that of other FDA Human Drug User fees. We then, using FDA-published information, analyzed where GDUFA facility and Drug Master File fees are coming from. We used the Orange Book to identify the sponsors of all approved Abbreviated New Drug Applications (ANDAs) and the S&P Capital IQ database to find the ultimate parent companies of sponsors of approved ANDAs. The key differences between the previous structure for Human Drug User fees and the GDUFA are as follows: GDUFA has no approved product fee and no first-time or small business fee exemptions and GDUFA charges facility fees from the time of filing and charges a foreign facility levy. Most GDUFA fees are paid by or on behalf of foreign entities. The top 10 companies hold nearly 50% of all approved ANDAs but pay about 14% of GDUFA facility fees. We conclude that the regressive nature of the GDUFA fee structure penalizes small, new, and foreign firms while benefiting the large established firms. A progressive fee structure in line with other human drug user fees is needed to ensure a healthy generic drug industry. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  8. Talking culture, crying health, hoping for nothing: surviving the many flyers above the human rights global cuckoo's nests.

    PubMed

    Vrzina, Sanja M Spoljar

    2011-12-01

    Today's talk about any health issue is part of a wider web of neoliberal destructive processes of which all fall into the category of discriminating populations and their cultures, downgrading their right to life and violating their human dignity. Poor health, poverty stricken health systems and screaming epidemiological factors make just one more triangle of the successive visible consequences of destruction that equals to the violation of human dignity, to begin with. Yet no correction is possible since every problem is tied to the double standard perceivement of Human Rights. The author is engaged in presenting a need of a deeper auto-reflexive work-through of our human approachments and biological realities. This urgent stance is based on the new, set by Kalny (2009) and Baxi (2006), orientation towards a critical reading of the Human Rights and the advocacy toward differentiating between the politics for human rights and politics of human rights (the later being the politics of rights instrumentalization). Health and its un-sustainability is one of the most dramatic areas in which this differentiation of ones approaches is dramatically felt and needed. The end conclusions are envisioned to support the already existing field of a number of dedicated critical medical anthropologists, as well as authors across all fields, in their demand for, nothing more or less than, the dignity for the populations that they/we daily represent.

  9. 76 FR 53908 - Determination That OPANA ER (Oxymorphone Hydrochloride) Extended-Release Tablets, 7.5 Milligrams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... milligrams (mg) and 15 mg, were not withdrawn from sale for reasons of safety or effectiveness. This... approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the...

  10. 77 FR 12309 - Determination That PHENURONE (Phenacemide) Tablet, 500 Milligrams, Was Not Withdrawn From Sale...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... not withdrawn from sale for reasons of safety or effectiveness. This determination will allow FDA to... withdraws or suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA...

  11. 76 FR 59141 - Determination That LOXITANE (Loxapine Succinate) Capsules and Three Other Drug Products Were Not...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice... document were not withdrawn from sale for reasons of safety or effectiveness. This determination means that... approval of the drug's NDA or ANDA for reasons of safety or effectiveness, or if FDA determines that the...

  12. 78 FR 17933 - Determination That BENADRYL (diphenhydramine hydrochloride) Injection and Two Other Drug Products...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION... effectiveness. This determination means that FDA will not begin procedures to withdraw approval of abbreviated... withdraws or suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness, or if FDA...

  13. 75 FR 48352 - Determination That MOTRIN (Ibuprofen) Tablets and Four Other Drug Products Were Not Withdrawn...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The... were not withdrawn from sale for reasons of safety or effectiveness. This determination means that FDA... approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the...

  14. 75 FR 81617 - Determination That TRANDATE (Labetalol Hydrochloride) Tablets, 300 Milligrams and 400 Milligrams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug Administration, HHS. ACTION... effectiveness. This determination means that FDA will not begin procedures to withdraw approval of abbreviated... withdraws or suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA...

  15. Investigation of the Progressive Bi-Level Coding Technique for the High- Resolution Bi-Level Data Compression Standard

    DTIC Science & Technology

    1990-07-01

    DOEdistribution categories from the Standard Distribution for Block 5. Funding Numbers. To include contract Unclassified Scientific and Technical and...a de -,sgee,-cnW iga danim -mihikihnct i "Erglit a n dr -. hviilchkan mi nu deike saitudwniesc rdn i u unLklvvrc mie rdrermlhe mSneahofc g~inttn ere

  16. Sanofi Pharmaceuticals, Inc., et al.; withdrawal of approval of 21 new drug applications and 62 abbreviated new drug applications--FDA. Notice.

    PubMed

    1998-05-12

    The Food and Drug Administration (FDA) is withdrawing approval of 21 new drug applications (NDA's) and 62 abbreviated new drug applications (ANDA's). The holders of the applications notified the agency in writing that the drug products were no longer marketed and requested that the approval of the applications be withdrawn.

  17. 76 FR 32366 - Determination That ORLAAM (Levomethadyl Acetate Hydrochloride) Oral Solution, 10 Milligrams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ...) Oral Solution, 10 Milligrams/Milliliter, Was Not Withdrawn From Sale for Reasons of Safety or... milligrams (mg)/milliliter (mL), was not withdrawn from sale for reasons of safety or effectiveness. This... the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the listed...

  18. The Future of Dance and/as Work: Performing Precarity

    ERIC Educational Resources Information Center

    Van Assche, Annelies

    2017-01-01

    This article explores how and to what extent precarity is intertwined with a contemporary dance artist's labour, life and art in the neoliberal society. Throughout this investigation my arguments are supported by insights from an on-going qualitative study that uses in-depth interviews and observations of working processes within the Brussels…

  19. A Diet, Physical Activity, and Meditation Intervention in Men With Rising Prostate-Specific Antigen (PSA)

    DTIC Science & Technology

    2006-05-01

    AD_________________ Award Number: DAMD17-03-1-0139 TITLE: A Diet , Physical Activity, and...A Diet , Physical Activity, and Meditation Intervention in Men With Rising Prostate- 5a. CONTRACT NUMBER Specific Antigen (PSA...favorably affected by an intensive, vegetable-based diet , plus physical activity and mindfulness-based stress reduction. This randomized trial will

  20. 77 FR 51816 - Notice of Opportunity To Withdraw Abbreviated New Drug Applications To Avoid Backlog Fee Obligations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ...] Notice of Opportunity To Withdraw Abbreviated New Drug Applications To Avoid Backlog Fee Obligations... to avoid paying a fee. The fee in question is a one-time backlog fee that was established through enactment of the Generic Drug User Fee Amendments of 2012 (GDUFA). It will apply to any original ANDA that...

  1. 78 FR 67365 - Determination That Adderall (Amphetamine Aspartate; Amphetamine Sulfate; Dextroamphetamine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ...; Dextroamphetamine Sulfate) Tablet and 13 Other Drug Products Were Not Withdrawn From Sale for Reasons of Safety or... withdrawn from sale for reasons of safety or effectiveness. This determination means that FDA will not begin... suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness, or if FDA determines...

  2. Interface of the general fitting tool GENFIT2 in PandaRoot

    NASA Astrophysics Data System (ADS)

    Prencipe, Elisabetta; Spataro, Stefano; Stockmanns, Tobias; PANDA Collaboration

    2017-10-01

    \\bar{{{P}}}ANDA is a planned experiment at FAIR (Darmstadt) with a cooled antiproton beam in a range [1.5; 15] GeV/c, allowing a wide physics program in nuclear and particle physics. It is the only experiment worldwide, which combines a solenoid field (B=2T) and a dipole field (B=2Tm) in a spectrometer with a fixed target topology, in that energy regime. The tracking system of \\bar{{{P}}}ANDA involves the presence of a high performance silicon vertex detector, a GEM detector, a straw-tubes central tracker, a forward tracking system, and a luminosity monitor. The offline tracking algorithm is developed within the PandaRoot framework, which is a part of the FairRoot project. The tool here presented is based on algorithms containing the Kalman Filter equations and a deterministic annealing filter. This general fitting tool (GENFIT2) offers to users also a Runge-Kutta track representation, and interfaces with Millepede II (useful for alignment) and RAVE (vertex finder). It is independent on the detector geometry and the magnetic field map, and written in C++ object-oriented modular code. Several fitting algorithms are available with GENFIT2, with user-adjustable parameters; therefore the tool is of friendly usage. A check on the fit convergence is done by GENFIT2 as well. The Kalman-Filter-based algorithms have a wide range of applications; among those in particle physics they can perform extrapolations of track parameters and covariance matrices. The adoptions of the PandaRoot framework to connect to Genfit2 are described, and the impact of GENFIT2 on the physics simulations of \\bar{{{P}}}ANDA are shown: significant improvement is reported for those channels where a good low momentum tracking is required (pT < 400 MeV/c).

  3. 77 FR 9944 - Determination That REQUIP XL (Ropinerole Hydrochloride) Extended-Release Tablets, 3 Milligrams...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... Parkinson's disease. REQUIP XL (ropinerole hydrochloride) extended-release tablets, 3 mg, are currently... amendments include what is now section 505(j)(7) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 355(j... suspends approval of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines...

  4. Monitoring Technology Proliferation: An Open Source Methodology For Generating Proliferation Intelligence

    DTIC Science & Technology

    1993-12-01

    72 D. MINES AND THE MILITARY-TECHNOLOGICAL REVOLUTION ...................................... 74 E. CUSTOMIZING THE TDD PROLIFERATION MARKET M...Data Storage & Peripherals - Systems Managmnt Technologies 4. Passive Sensors - Sensors and Signal Processing 5. Photonics - Electronic and...a reproducible procedure to allow customization of the model, provides the "guts" of the method. 18 Third, because they are not optimized for

  5. Performance Models of Testability.

    DTIC Science & Technology

    1984-08-01

    4.1.17 Cost of Isolating Component/Part (CPI) 5J Cost of isolating components or parts at the depot is at CPI - n1 (HDC)(TPI)(NPI) where TPI = average...testing component N Deec N a aiur Yes(PFD D)S Cos ofi oaig op nn -- Cost ofcmpnn rmva n relaemn Exece Cost of omponn reatmovae anda

  6. 76 FR 37129 - Determination That SODIUM FLUORIDE F 18 (Sodium Fluoride F-18) Injection, 10 to 200 Millicuries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ...] Determination That SODIUM FLUORIDE F 18 (Sodium Fluoride F-18) Injection, 10 to 200 Millicuries per Milliliter... FLUORIDE F 18 (sodium fluoride F-18) injection, 10 to 200 millicuries per milliliter (mCi/mL), was not... abbreviated new drug applications (ANDAs) for SODIUM FLUORIDE F 18 injection, 10 to 200 mCi/mL, if all other...

  7. Naval Medical Research and Development News. Volume 7, Issue 11, November 2015

    DTIC Science & Technology

    2015-11-01

    enteric diseases such as shigellosis and typhoid fever . The goal of the laboratory is to research, understand, and develop protective strategies...military or public health significance in the region, including malaria and dengue fever , yellow fever , viral encephalitis, leishmaniasis, and...a food and waterborne disease, is characterized by fever , cramps and sometimes severe bloody diarrhea,” said Cmdr. Christopher Duplessis, lead

  8. Risk Propensity and Health Risk Behaviors in U.S. Army Soldiers with and without Psychological Disturbances across the Deployment Cycle

    DTIC Science & Technology

    2012-02-09

    screening instruments, participants were categorized with respect to PTSD and probable TBI. Results suggest that Soldiers engage in more alcohol use and...a longitudinal study will provide stronger evidence to our understanding of the relationships between deployment and adverse health outcomes...and alcohol use, and cost-benefit analysis tasks. The results of this study showed that cognitive regulation was predictive of rational decision

  9. Multiple Frequency Parametric Sonar

    DTIC Science & Technology

    2015-09-28

    300003 1 MULTIPLE FREQUENCY PARAMETRIC SONAR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...a method for increasing the bandwidth of a parametric sonar system by using multiple primary frequencies rather than only two primary frequencies...2) Description of Prior Art [0004] Parametric sonar generates narrow beams at low frequencies by projecting sound at two distinct primary

  10. Asbestos Workshop: Sampling, Analysis, and Risk Assessment

    DTIC Science & Technology

    2012-03-01

    coatings Vinyl/asbestos floor tile Automatic transmission components Clutch facings Disc brake pads Drum brake linings Brake blocks Commercial and...A naturally-occurring pliant and fibrous mineral with heat-resistant properties • Serpentine Class: joint compound,‘popcorn’ceilings, brake pads...fabrics, and is used in fire-resistant and insulating materials such as brake linings. The asbestos minerals include chrysotile (white asbestos) and

  11. Russia’s Reactions to the Color Revolutions

    DTIC Science & Technology

    2017-03-01

    Democratic Institute NGO non -governmental organization ODIHR Office for Democratic Institutions and Human Rights OSCE Organization for Security and...as the United States and other Western partners continue their tradition of promoting democracy and encouraging non -governmental organization (NGO...Ukraine as genuinely popular and indigenous upheavals, largely ignoring the role of U.S. funding and U.S. non -governmental organisations in

  12. Affect and/as Collective Resistance in a Post-Truth Moment

    ERIC Educational Resources Information Center

    Castro Samayoa, Andrés; Nicolazzo, Z

    2017-01-01

    In this piece, we call upon the value of coalitional politics as a strategy of resistance in the face of an increasingly powerful post-truth regime. Reflecting on the insidious effects of fact-denying discourses are echoed in our classrooms and in our roles as educators, we openly wonder: What might it mean for educators to use feelings as a guide…

  13. Hypernuclear physics studies of the P̅ANDA experiment at FAIR

    NASA Astrophysics Data System (ADS)

    Sanchez Lorente, Alicia

    2015-05-01

    Hypernuclear research will be one of the main topics addressed by the PANDA experiment at the planned Facility for Antiproton and Ion Research FAIR at Darmstadt (Germany). [1, 2] Thanks to the use of stored p̅ beams, copious production of double Λ hypernuclei is expected at the PANDA experiment, which will enable high precision γ spectroscopy of such nuclei for the first time, and consequently a unique chance to explore the hyperon-hyperon interaction. In particular, ambiguities of past experiments in determining the strength of the ΛΛ interaction will be avoided thanks to the excellent energy precision of a few keV (FWHM) achieved by germanium detectors. Such a resolution capability is particularly needed to resolve the small energy spacing of the order of (10-100) keV, which is characteristic from the spin doublet in hypernuclei the so -called "hypernuclear fine structure". In comparison to previous experiments, PANDA will benefit from a novel technique to assign the various observable γ-transitions in a unique way to specific double hypernuclei by exploring various light targets. Nevertheless, the ability to carry out unique assignments requires a devoted hypernuclear detector setup. This consists of a primary nuclear target for the production of Ξ- + overline Xi pairs, a secondary active target for the hypernuclei formation and the identification of associated decay products and a germanium array detector to perform γ spectroscopy. Moreover, one of the most challenging issues of this project is the fact that all detector systems need to operate in the presence of a high magnetic field and a large hadronic background. Accordingly, the need of an innovative detector concept will require dramatic improvements to fulfil these conditions and that will likely lead to a new generation of detectors. In the present work details concerning the current status of the activities related to the detector developments for this challenging programme will be given. Among these improvements is the new concept for a cooling system for the germanium detector based on a electro-mechanical device. In the present work, the cooling efficiency of such devices has been successfully tested, showing their capability to reach liquid nitrogen temperatures and therefore the possibility to use them as a good alternative to the standard liquid nitrogen dewars. Furthermore, since the momentum resolution of low momentum particles is crucial for the unique identification of hypernuclei, an analysis procedure for improving the momentum resolution in few layer silicon based trackers is presented.

  14. Applications for approval to market a new drug; complete response letter; amendments to unapproved applications. Final rule.

    PubMed

    2008-07-10

    The Food and Drug Administration (FDA) is amending its regulations on new drug applications (NDAs) and abbreviated new drug applications (ANDAs) for approval to market new drugs and generic drugs (drugs for which approval is sought in an ANDA). The final rule discontinues FDA's use of approvable letters and not approvable letters when taking action on marketing applications. Instead, we will send applicants a complete response letter to indicate that the review cycle for an application is complete and that the application is not ready for approval. We are also revising the regulations on extending the review cycle due to the submission of an amendment to an unapproved application and starting a new review cycle after the resubmission of an application following receipt of a complete response letter. In addition, we are adding to the regulations on biologics license applications (BLAs) provisions on the issuance of complete response letters to BLA applicants. We are taking these actions to implement the user fee performance goals referenced in the Prescription Drug User Fee Amendments of 2002 (PDUFA III) that address procedures and establish target timeframes for reviewing human drug applications.

  15. (YIP-09) Improving Synthesis and Recognition of Crowded Scenes using Statistical Models of Group Behavior

    DTIC Science & Technology

    2013-05-01

    prisoner’s dilemma. In Proceedings of Florida Artifical Intelligence Research Society, pages 2–7, Day- tona Beach, FL, May 2010. [6] M. Maghami* and...A. Shah*, P. Bell*, and G. Sukthankar. A destination recommendation system for virtual worlds. In Proceedings of Florida Artifical Intelligence ...question convey? Leveraging help-seeking behavior for improved modeling in a simulation- based intelligent tutor. In Proceedings of SpringSim Military

  16. An Investigation of the Pareto Distribution as a Model for High Grazing Angle Clutter

    DTIC Science & Technology

    2011-03-01

    radar detection schemes under controlled conditions. Complicated clutter models result in mathematical difficulties in the determination of optimal and...a population [7]. It has been used in the modelling of actuarial data; an example is in excess of loss quotations in insurance [8]. Its usefulness as...UNCLASSIFIED modified Bessel functions, making it difficult to employ in radar detection schemes. The Pareto Distribution is amenable to mathematical

  17. Identification of Microbial Gene Biomarkers for in situ RDX Biodegradation

    DTIC Science & Technology

    2012-12-01

    Additional research is required to determine reliable guidelines to inform site managers of specific field concentrations of ammonium and nitrate...Mrs. Cynthia L. Price, Research Biologist, EPED, EL, ERDC; Dr. Rick Arnseth, Project Manager / Geochemist, Tetra Tech Inc., Oak Ridge, TN; and...a biomarker of RDX degradation, as it will also be necessary for bioremediation site managers to measure soil and groundwater concentra- tions for

  18. Variability of Hormonal Stress Markers and Stress Responses in a Large Cross-Sectional Sample of Elephant Seals

    DTIC Science & Technology

    2014-09-30

    hormones and function in elephant seals; 3) determine the impact of baseline variation in aldosterone on electrolyte balance in elephant seals; 4...may have broad implications for marine mammal species. Task 3 – Impact of aldosterone variability on osmolality Work on the Parent Project and...a parallel project on bottlenose dolphins has shown the importance of aldosterone as a stress hormone in marine mammals. Aldosterone covaries with

  19. 26 CFR 301.9100-7T - Time and manner of making certain elections under the Tax Reform Act of 1986.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...(p)(1) of the Act. [See paragraph (a)(2)(vii) and(a)(3)(x) of this section.] 1882(c) 3121(w)(2... absence from the United States during the election year that are deemed to be days of presence. (x... the election described in H.R. Rep. No. 99-841 at II-320, 811(a) 453C(b)(2)(B)(i), 453C(e)(4) 905(a...

  20. 26 CFR 301.9100-7T - Time and manner of making certain elections under the Tax Reform Act of 1986.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...(p)(1) of the Act. [See paragraph (a)(2)(vii) and(a)(3)(x) of this section.] 1882(c) 3121(w)(2... absence from the United States during the election year that are deemed to be days of presence. (x... the election described in H.R. Rep. No. 99-841 at II-320, 811(a) 453C(b)(2)(B)(i), 453C(e)(4) 905(a...

  1. 26 CFR 301.9100-7T - Time and manner of making certain elections under the Tax Reform Act of 1986.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...(p)(1) of the Act. [See paragraph (a)(2)(vii) and(a)(3)(x) of this section.] 1882(c) 3121(w)(2... absence from the United States during the election year that are deemed to be days of presence. (x... the election described in H.R. Rep. No. 99-841 at II-320, 811(a) 453C(b)(2)(B)(i), 453C(e)(4) 905(a...

  2. Harmonizable Processes: Structure.

    DTIC Science & Technology

    1980-11-05

    Grothendieck and Pietsch , for * the work below. Definition 5.2 Let 1,4 be a pair of Banach spaces andas usual, B(1,4) be the space of bounded linear...IP)P P i=l I - (58) xi E 1, 1 i < n , n where x* E 1* , the adjoint space of I The following result of Grothendieck- Pietsch with a short proof may

  3. A Comparative Analysis of Unit Cohesion in Vietnam

    DTIC Science & Technology

    2014-06-13

    the political process, and result in a communist government; this became known as the Domino Theory . The United States replaced the French and...a theory of linkage; leveraging the political ties of Communist countries, namely the USSR and China, to influence North Vietnam, and deterrence; a...and Henderson provide some of the more popular theories about cohesion. Winkler points out that the relationship between stability, cohesion and

  4. Combinatorial and Algorithmic Rigidity: Beyond Two Dimensions

    DTIC Science & Technology

    2012-12-01

    problem. Manuscript, 2010. [35] G. Panina and I. Streinu. Flattening single-vertex origami : the non- expansive case. Computational Geometry : Theory and...in 2008, under the DARPA solicitation “Mathemat- ical Challenges, BAA 07-68”. It addressed Mathematical Challenge Ten: Al- gorithmic Origami and...a number of optimal algorithms and provided critical complexity analysis. The topic of algorithmic origami was successfully engaged from the same

  5. Grounding Vision through Experimental Manipulation

    DTIC Science & Technology

    2002-01-01

    Speculatrix" by their creator to emphasise their exploratory behaviour , described as: "it explores its environment actively, persistently, systematically...as most animals do" (Walter, 1950). These robots had very simple control circuitry, and their behaviour depended greatly on the morphology and...a long developing process. More studies are needed though to ascertain how the dorsal pathway (action) influences the ventral (perception) both in

  6. Calibration of Attenuation Structure in Eurasia to Improve Discrimination and Yield

    DTIC Science & Technology

    2010-09-01

    and travel-times over large and tectonically complicated regions. As a result regional discrimination methods (e.g., high-frequency P/S, Ms:mb) and...a poor job of predicting both regional amplitudes and travel-times over large and tectonically complicated regions. As a result regional...regions. Earthquake-explosion discrimination using high-frequency regional P/S amplitude ratios over large and tectonically complicated regions can only

  7. Analysis of Non-Pivotal Bioequivalence Studies Submitted in Abbreviated New Drug Submissions for Delayed-Release Drug Products.

    PubMed

    Kaur, Paramjeet; Jiang, Xiaojian; Stier, Ethan

    2017-01-01

    The US FDA's rule on "Requirements for Submission of Bioequivalence Data" requiring submission of all bioequivalence (BE) studies conducted on the same formulation of the drug product submitted for approval was published in Federal Register in January 2009. With the publication of this rule, we evaluated the impact of data from non-pivotal BE studies in assessing BE and identified the reasons for failed in vivo BE studies for generic oral delayed-release (DR) drug products only. We searched the Agency databases from January 2009 toDecember 2016 to identify Abbreviated New Drug Applications (ANDAs) submitted for DR drug products containing non-pivotal BE studies. Out of 202 ANDAs, 43 ANDAs contained 102 non-pivotal BE studies. Forty-nine non-pivotal BE studies were conducted on the to-be-marketed (TBM) formulation and 53 were conducted on formulations different from the TBM formulation. These experimental formulations primarily differed in the ratio of components of the enteric coating layer and/or amount (i.e., %w/w) of enteric coating layer. Of the 49 non-pivotal BE studies conducted on the TBM formulation, 41 failed to meet the BE acceptance criteria. The majority of failed non-pivotal BE studies on the TBM DR generic products had insufficient power, which was expected as these studies are exploratory in nature and not designed to have adequate power to pass the BE statistical criteria. In addition, among the failed non-pivotal BE studies on the TBM DR generic products, the most commonly failing pharmacokinetic parameter was Cmax. The data from these non-pivotal BE studies indicate that inadequate BE study design can lead to failure of the BE on the same formulation. Also, the non-pivotal BE studies on formulations different from the TBM formulation help us link the formulation design to the product performance in vivo. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue

  8. Problems on the Theory of Heat Resistance of Alloys

    DTIC Science & Technology

    1960-07-26

    same material under real service conditions is conceded; in this case, the shapes and dimensions of the product, the vibrations, the sharp and...as the load duration factor). The introduction of a newly created material some- times proves unsuccessful due to the fact that, though meeting all...structural nonuniformity of real solids on the mechanism of the development of deformation in them and on their mechanical properties*; (d) the influence of

  9. Plutonium Bioassay Testing of U.S. Atmospheric Nuclear Test Participants and U.S. Occupation Forces of Hiroshima and Nagasaki, Japan

    DTIC Science & Technology

    2015-10-30

    with nuclear weapons testing or plutonium work. The results for the 100 atomic veterans were compared to those of the unexposed population, and...as a marker for significant internal intakes of other associated radionuclides in nuclear weapons debris due to its low natural background. However...isotope in weapons grade plutonium, is important from a health perspective, its presence within a given urine sample being analyzed by FTA can only

  10. Operational Cybersecurity Risks and Their Effect on Adoption of Additive Manufacturing in the Naval Domain

    DTIC Science & Technology

    2017-12-01

    material and limiting overproduction issues experienced in traditional manufacturing . Figure 2 shows how AM may also speed productivity by reducing time...schematic from a file and have a computer printer create that item in real life layer by layer 30. Geek method of manufacture at low rate of production and...a three dimensional form. 46. Additive production technique utilizing material extruded onto a bed, usually in 3-axes. 47. Additive manufacturing

  11. The China-Africa Connection: Implications for United States Foreign Policy

    DTIC Science & Technology

    1992-06-01

    a Independencia total de Angola(UNITA) UNITA Governo Revolucionhrio de Angola _.. ... no Exillo LGRAE) GRAE Mozambique Frente de Liberta;&o de ...Moqambique (FRELIMO) FRELIMO Comite Revolucionhrio de ,, Mocambigue (COREMO) COREMO Portuguese Partido Africano da Independencia Guinea da Guind e Cabo Verde...Postgraduate School Naval Postgraduate School NS _-. ’E_ ADURESSb (UIly, MStae, anda 2P c- de ) 71). ADDRESS (GiIy, SMate, and/-JP Code) Monterey, CA 93943

  12. A Pulse Code Modulated Fiber Optic Link Design for Quinault Under-Water Tracking Range.

    DTIC Science & Technology

    1980-09-01

    invented and patented a light-wave communications device, the Photophone . The light beam was acoustically modulated, transmitted through the atmosphere and...a load resistor or feedback resistor. This voltage can be cal- culated by multiplying the received power, the respcnsiv ity and the effective load...frequency is not real critical since the clock, in effect , is synchronized after every eight bits by the timing pulse. The more interesting part of the

  13. Market Survey and Analysis in Support of ASAS Computer-Based Training System Design

    DTIC Science & Technology

    1988-11-01

    development nf a recommended strategy for incorporating CBT in the ASAS/ENSCE training system. Approach - In order to establish the state of the art and...a training system which will meet ASAS training requirements. Eleven subsystems are described in terms of their functional input to the overall...keyboard and displays used in actual operation are also used in training, maximizing the transfer effect from practice situations to actual system

  14. Quantifying Stellar Mass Loss with High Angular Resolution Imaging

    DTIC Science & Technology

    2009-02-19

    material – via massive winds, planetary nebulae and supernova explosions – seeding the interstellar medium with heavier elements. Subsequent...of Planetary Nebulae (Harpaz, ApJ, 498,293, (1998)), impacts the pre-explosion characteristic of SNII (Taylor, “The Stars”, Cambridge (1994)), and...A 464, 119) or may have an important role, such as Be Stars, W-R stars, and planetary nebulae . The Future of Interferometric O/IR Imaging. The

  15. New Cathode Material for High Energy-Density Batteries

    DTIC Science & Technology

    1974-07-31

    Lithium Anodes LINK A ROLK LINK B LINK C INSTRUCTIONS I. ORIGINATING ACTIVITY: Enter the name and oddM-ss of the contractor...theoretical energy density of 399 whr/lb when paired with a lithium anode. Results of related, but less extensive, work on zinc fluoride and...a) The semiconductor was cathodically passi- vated in the presence of lithium ions, which would normally exist in lithium battery electrolytes

  16. Integrated Spatial Models of Non Native Plant Invasion, Fire Risk, and Wildlife Habitat to Support Conservation of Military and Adjacent Lands in the Arid Southwest

    DTIC Science & Technology

    2015-12-01

    FINAL REPORT Integrated spatial models of non-native plant invasion, fire risk, and wildlife habitat to support conservation of military and...as reflecting the official policy or position of the Department of Defense. Reference herein to any specific commercial product, process, or service...2. REPORT TYPE Final 3. DATES COVERED (From - To) 26/4/2010 – 25/10/2015 4. TITLE AND SUBTITLE Integrated Spatial Models of Non-Native Plant

  17. Joint Information Environment: DOD Needs to Strengthen Governance and Management

    DTIC Science & Technology

    2016-10-25

    while JIE should not result in a net increase in required manpower , the types of skill sets and collocation of those skill sets into regional and...As a result , DOD risks having a deficient security posture and not being able to ensure that it will have the appropriate workforce knowledge and...initiative to consolidate IT infrastructure to achieve savings in acquisition, sustainment, and manpower costs and improve the department’s ability

  18. Perspectives on Defense Futures: National Developments in Europe

    DTIC Science & Technology

    1986-04-01

    little danger of coming apart at the seam in the next 10 years, fiscal constraints on improving defenses will be a dominant environmental factor and...a source of further intra- Alliance frictions. European maritime forces, in particular, will feel the effects of a fiscally corseted planning...EXECUTIVE SUMMARY EUROPE IN THE LATE 198Qs sets the context with a brief survey of the political, fiscal , and force modernization challenges

  19. Comprehensive Nuclear-Test-Ban Treaty: Updated ’Safeguards’ and Net Assessments

    DTIC Science & Technology

    2009-06-03

    measures that this nation can take unilaterally within the treaty to protect its nuclear security. To compensate for “disadvantages and risk” they...and strategic forces, and could be augmented with implementation measures . While Safeguards may be part of a future CTBT debate, both supporters and...A second path involves efforts to alter the net assessment through measures intended to mitigate perceived risks of the treaty. This path has been

  20. Buying ’Green’: Implementation of Environmentally-Sound Purchasing Requirements in Department of Defense Procurements

    DTIC Science & Technology

    1993-09-30

    contract for the removal, transportation and disposal of miscellaneous hazardous items located at installations in and around the Naval Air Station at...tary weapons designed for combat use, certain National keronautics and Space Administration (NASA) rockets, and Covernment experimental machinery and...as such terms are defined in Section 101 of the Federal Aviation Act of 1958; or (ii)(a) Any military weapons or equipment which are designed for

  1. Outsourcing Information Technology and the Insider Threat

    DTIC Science & Technology

    2003-03-01

    the insider threat. However, “are of little value for examining complex social relationships or intricate patterns of interaction ” (Marshall and...As the previous section indicated, U.S. relations with the rest of the world will have some bearing over the social interactions , trends, and psyches...advances that bring economic and social issues into focus in a media rich environment. Technology trends have given organizations the ability to

  2. Evaluation of the Safety and Efficacy of the FAAH Inhibitor URB597

    DTIC Science & Technology

    2016-01-01

    contracts!and!business!was!initiated.!As! requested!by!USAMRAA!the!1.5kg!of!URB597!that!had!produced!by!vendor!STA! Pharmaceutical! Hong ! Kong !Limited...Pharmaceutical! Hong ! Kong !Limited,!and!New!York! University!School!of!Medicine,!a!contract!was!executed!on!September!26,!2014,!and!a! Purchase!Order!was!issued...instructed by USAMRMC, August 2015. 15.2SUBJECT2TERMS post traumatic stress disorder, OEF/OIF clinical trial, FAAH, CB1 receptor, brain imaging

  3. AutoMap User’s Guide 2011

    DTIC Science & Technology

    2011-06-13

    important links. Dave likes milk and cookies but John likes cauliflower 107 The example sentence above contains nine concepts. Manually reviewing this...sentence reveals that milk and cookies are associated with Dave and cauliflower is associated with John. But using a direction of unidirectional and...a window size of 9 results in cauliflower also being associated with Dave. 18 JAN 10 GUI Section The AutoMap GUI is a graphic interface for

  4. The Future of Military Graduate Medical Education

    DTIC Science & Technology

    1992-01-08

    Army alone is the country’s largest comprehensive Health Maintenance Organization(HMO). Over the past 45 years, this work force, balancing the competing...that have to be balanced to protect national priorities. As always, costs and budgets will play a major role in determining what is maintained and...a slightly different way. For instance, the Navy generally requires all its medical officers to do some general medical officer work before going on

  5. Microbiologically Influenced Corrosion in Copper and Nickel Seawater Piping Systems

    DTIC Science & Technology

    1990-09-01

    Influenced Tipton, D. G. and Kain, R. M. 1980. Effect of temperature onCorosiope in Nuclear Power Plants atudy a Mical Gnuide the resistance to pitting of...Monel alloy 400 in seawater. In:Corrosion in Nuclear Power Plants anda Practical ie fr Proceedings of Corrosion 󈨔. Chicago, Illinois: National...Sons Ltd. 441 pp. Quimica . Verink, E.D. and Pourbaix, M. 1971. Use of electrochemical Pope, D. H., Duquette, D. J., Johannes, A. H., and Wayner

  6. Friction in U.S. Foreign Policy: Cultural Difficulties with the World

    DTIC Science & Technology

    2006-03-15

    the intrusive and high-handed behaviour of the West. We see examples of this kind of attitude all around the world from Latin America to Africa and...a distracting rhetoric to conceal the root causes of Latin American poverty—a culture of outright corruption and exploitation of the people and land...and organized crime are now distinct from each other, rising anti-Americanism could cause Latin American organized crime figures to be more willing

  7. Quality Control Review of the Defense Intelligence Agency, Office of Inspector General, Audit Division

    DTIC Science & Technology

    2015-02-26

    mission is to support the overall DIA OIG role of providing oversight of and reporting upon matters, which pertain to the performance of mission and...as discussed throughout this report. In the two IPERA audits, the DIA OIG Audit Division auditors found that DIA did not comply with the IPERA. For...Independence Not Followed For two of the three audits reviewed, the auditors did not follow the GAGAS conceptual framework for independence. GAGAS

  8. Targeted Ablation of CML Stem Cells

    DTIC Science & Technology

    2007-01-01

    centuries .12 More recently, PTL has been found to have several other properties, including antitumor activity, inhibition of DNA synthesis, and...as a chemopreventive agent in a UVB-induced skin cancer animal model. 21 PTL is a potent inhibitor of NF-B activation and has been shown to directly...diluted in phosphate buffer saline (PBS). Ara-C was obtained from Sigma ( St Louis, MO). Total cell numbers were determined before and after culture for

  9. Animal Models of Jet Lag

    DTIC Science & Technology

    2012-01-20

    surgically inserted into the pineal gland and connected to a peristaltic pump that delivers saline solution at low rate and to a outlet tubing that delivers...Journal of Pineal Research. 48(3):290- 6,2010. 2. "Orcadian Regulation of Pineal Gland Rhythmicity", Jimo Borjigin, L. Samantha Zhang, Anda-Alexandra...specializes in the longitudinal monitoring of pineal melatonin secretion for weeks at a time to decipher mechanisms of circadian pacemaker entrainment

  10. Commerce Raiding: Historical Case Studies, 1755-2009

    DTIC Science & Technology

    2013-10-01

    Ariel proceed under bond.26 On 23 December, Alabama met Agrippina at the Arcas Islands off Yucatan and spent a week there taking on supplies and...as the population on the home islands. In particular, the U.S. unrestricted campaign dra- matically reduced the nutritional intake of most Japanese...See Jeune École Yucatan 80 Yusuf, Abdullahi 260, 262–63 Z Z, Operation 182 Zanzibar 128 Zeebrugge 140 Zhili Province 105, 108 The Newport

  11. A Development Model for Foreign Police

    DTIC Science & Technology

    2014-06-13

    automated fingerprint identification system. And lastly, it sought to provide training to Malian and other regional police on countering money laundering and...A DEVELOPMENT MODEL FOR FOREIGN POLICE A thesis presented to the Faculty of the U.S. Army Command and General Staff College in...13-06-2014 2. REPORT TYPE Master’s Thesis 3. DATES COVERED (From - To) AUG 2013 – JUNE 2014 4. TITLE AND SUBTITLE A DEVELOPMENT MODEL FOR

  12. An Investigation Concerning the Potential for use of Polylactic/Polyglycolic Acid Confluent Sheets in the Treatment of Osseous Defects,

    DTIC Science & Technology

    1992-01-01

    Periodontics and Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, MO 64108. •* Departments of Hospital Dentistry and...as a matrix for osseous grafting, for the occlusion of large bony defects, for soft tissue contour defects, and also as a bone plating system. All of...Hunsck EE: Tissue reaction to biodegradable polylactide acid suture. Oral Surg, 31:134, 1971. 5. Kulkurni RK, Pani KC, Neuman C, et al.: Polylactic acid

  13. The Average Change in Facial Height Following Bilateral Sagittal Split Osteotomy Advancement in Class II Patients

    DTIC Science & Technology

    2017-04-21

    The S9 CRD/Publications and Presentations Section will route the request form to clinical investigations. 502 ISG/JAC ( Ethics Review) and Public...information. 11 . The Joint Ethics Regulation (JER) DoD S500.07-R. Standards of Conduct. provides standards of ethical conduct for all DoD personnel and...a legal ethics review to address any potential conflicts related to DoD personnel participating in non-DoD sponsored conferences, professional

  14. Natural Gas Propulsion Options for Short Sea Shipping Routes

    DTIC Science & Technology

    2010-08-01

    that are involved with gas and the relevant systems, along with personal protection issues that come into effect when handling both compressed and...a compressed air system for engine starting, which is stored in compressed air storage cylinders . The system leads compressed air through a valve...directly into the cylinder heads at 30bar to begin the rotation of the engine. After this rotation occurs, the engine is supplied with diesel fuel

  15. Rethinking Third-Party Intervention into Insurgencies: The Logic of Commitment

    DTIC Science & Technology

    2010-04-14

    Isaiah Wilson III, “Rage Against the Machines: Explaining Outcomes in Counterinsurgency Wars,” International Organization 63, no. 1 (2009): 67-106 and...a chosen goal and it drives people to act consistently because it would be morally wrong, practically inexpedient, or both to do otherwise.49 Thomas ...prospects for future activity by the intervener. 50 Thomas C. Schelling, Arms and Influence (New Haven, CT: Yale University Press, 2009), 49. 51 Ibid., 65-6

  16. Investigations of Reactive Processes at Temperatures Relevant to the Hypersonic Flight Regime

    DTIC Science & Technology

    2014-10-31

    molecule is constructed based on high- level ab-initio calculations and interpolated using the reproducible kernel Hilbert space (RKHS) method and...a potential energy surface (PES) for the ground state of the NO2 molecule is constructed based on high- level ab initio calculations and interpolated...between O(3P) and NO(2Π) at higher temperatures relevant to the hypersonic flight regime of reentering space- crafts. At a more fundamental level , we

  17. Attacking the Lion: A Study of Cohesion in Naval Special Warfare Operational Units

    DTIC Science & Technology

    2011-06-01

    of Existential Courage.‖ Journal of Humanistic Psychology 44, no. 3 (Summer 2004): 279–298. ———. ―Relevance of Hardiness Assessment and Training to...stealth, teamwork, and violence of action to survive and succeed in missions against larger opponents. Developing bonds of trust between individuals and...a force that conducts kinetic action missions with an emphasis on speed, surprise, and violence of action. For the most part, this mentality

  18. United States Air Force Graduate Student Research Program. Program Technical rept. Volume 3

    DTIC Science & Technology

    1988-12-01

    placing scalp electrodes in a bipolar arrangement. An additional problem we faced in the F4 study was time- loc ::ing the ERP to the eliciting...and Leo Jehl of OEHL for their help with halide and metal analysis that was invalubae to this project. John Barnaby, Will Robinson, Chris Ritter, and...a patient teacher of statistical methods. Dr Eric D. Grassman and Dr Leo Spaccavento explained many technical cardiological points and were generally

  19. Natural Gas as an Instrument of Russian State Power (Letort Paper)

    DTIC Science & Technology

    2011-10-01

    effects the price increase had on the Ukrainian industry as a whole; and does not account for the costs to the Ukrainian economy of the 2006 and...a political consideration); and the differential cost of sanctions among the senders (largely an economic factor). First, allies hardly ever agree...sanctions is extremely hard to realize. 5 Second, the cost of imposing sanctions is sim- ply greater for some sender states than the potential

  20. Short-Sighted Probabilistic Planning

    DTIC Science & Technology

    2013-08-01

    2005). The 1st Probabilistic Track of the International Planning Competition. Journal of Artificial Intelli - gence Research, 24(1):851–887. [Zhou and...A short-sighted problem is a relaxed problem in which the state space of the original problem is pruned and artificial goals are added to...A short-sighted problem is a relaxed problem in which the state space of the original problem is pruned and artificial goals are added to heuris

  1. Environmental Inventory Report. East St. Louis and Vicinity, Cahokia Canal Drainage Area, Madison and St. Clair Counties, Illinois. Volume 4.

    DTIC Science & Technology

    1981-05-01

    successive waves of Indian, French , British, and Americans to what is now Madison and St. Clair Counties. This section of the Cahokia Canal...by the French . In 1673 the Jesuit missionary, Marquette, anda fur-trader, Jol iet, descended the Mississippi by canoe to a point somewhere south of...it. French Settlements The French were also the first to attempt permanent settlements in Illinois. In 1675, at a site near present day Utica in La

  2. Increased Economic Relations Between China and Zambia in the Last Decade: Implications on Zambia’s Existing Bilateral Relations with the United States

    DTIC Science & Technology

    2013-12-13

    Pacific region, but also the world at large. China and the U.S. have agreed to a new model of relations, based on practical cooperation and...as a significant model to determine whether the increase in China and Zambia relations lead to a change in the nature of bilateral relations between...a model in countries with similar features and given the circumstances. The last decade has seen China step up its economic activities on the

  3. Global 󈧌, U.S. Navy Title X War Game: Implementing the Maritime Strategy, 4-8 August 2008. Game Report

    DTIC Science & Technology

    2009-03-01

    flying in formation over the beach as an aggressive or hostile act. Similarly, for political reasons the U.S. may need to allow the host nation to put a...levels will result in migration flows and could cause instability, especially in smaller, coastal states. Aging populations, pollution -related and...a broad spectrum of experience from the DoD, U.S. Government, NGOs, academia, and representatives from Argentina, Brazil, Chile, Columbia, and Peru

  4. Fracture Characteristics of Structural Steels: Reference Manual

    DTIC Science & Technology

    1979-04-01

    materials were fractured undcr tensile, fatigue, and impact loading con- ditions. The effects of hydrogen embrittlement on the steels ’ behavior when...years after paint failure. The composition and the heat treatment of 4160 steel results in a steel extremely susceptible to stress corrosion cracking and...A35 Fracture Surface of Tensile Specimen No. 3 322 22 IL TABLES Number Page 1 Chemical Composition of Steels and Weld Metal 32 2 Welding Parameters 33

  5. Bands and/as Music Education: Antinomies and the Struggle for Legitimacy

    ERIC Educational Resources Information Center

    Mantie, Roger

    2012-01-01

    This article serves to extend a critique initiated by Allsup and Benedict in their 2008 PMER article, "The Problems of Band." Using the work of Michael Foucault as a theoretical and methodological basis, I consider ways in which today's large ensemble paradigm, particularly that of the wind band, has resulted in an ongoing antinomy in…

  6. Microsoft PowerPoint - ANDA-Webinar-Nov-2016-v4-CN yic. ...

    Center for Drug Evaluation (CDER)

    ... Julia Lee 药学博士 美国食品药品管理局（ FDA） ... 点击可看到相关信息 : ... 点击此链接进行评估和获得证书 了解 CDER 小型企业和行业协助处的其他资源 : ...

  7. 2007 Kneller Lecture, AESA Getting Lost: Social Science and/as Philosophy

    ERIC Educational Resources Information Center

    Lather, Patti

    2009-01-01

    This article probes how philosophical structures are immanent in empirical work and how philosophy might be understood when it is within the precincts of science. My interest is in both opening philosophy to disruption by a science that knows itself as inside history and opening science to the costs of its inability to tolerate the necessary lack…

  8. Computational Methods for Complex Flowfields

    DTIC Science & Technology

    1989-07-05

    This treatment is easily every ohrgi ie(i.9.Telclyfns el a extedd fo a-D knds pinerfces. Ths reuatemen rost e belong to either an unembedded or an...leading edge region is embedded in both directions. The downstream region between the two shear layers remains unembedded . Comparison of the grid and...A2 are unembedded coarse cells with vertical dimensions twice those of cells As, A4. It is clear that an evaluation for example, of the viscous

  9. Providing Technical Expertise for Effective Contract Management

    DTIC Science & Technology

    2011-04-12

    back to both the finance leg and the contracting leg . In order to avoid a conflict of interest or give the impression of 4 any improprieties...each leg of this triad is separate. It is this reason and those already mentioned that the COR is the responsibility of the requiring activity and...A. Fulghum, DoD Logistician Optimistic About Afghanistan (Aviation Week’s DTI , January 27, 2010) as reported on military.com, accessed on 15 February

  10. U.S. Army Corps of Engineers Manpower Information System: An Integrated Approach to Manpower Management

    DTIC Science & Technology

    1994-04-01

    engineering and con- struction management services for both military and civil works programs. In FY93, the cost of those programs exceeded $10 billion and...A related issue was to explore the USACE costs , benefits, and barriers to implementing a single Class VI system software package for both the military...provide information in useful ways, track utilization information, I A Class HI system is defined in AR 25-3. It is a system whose total program costs are

  11. Faked headaches becoming real.

    PubMed

    Haan, Joost

    2013-06-01

    In the gangster movie White Heat, the main character, Cody (played by James Cagney), suffers from 2 headache attacks. Here, I analyze these attacks by using the International Headache Society criteria, but an unequivocal diagnosis is not possible. Nevertheless, the attacks play an important role in the narrative and--as representation of something between "real" (mimesis) and not real--provide a ground for reflection on how to think of headache in general. © 2013 American Headache Society.

  12. Archeological Investigations in Cochiti Reservoir, New Mexico. Volume 3. 1976-1977 Field Seasons.

    DTIC Science & Technology

    1979-01-01

    or methods are in a constant state of flux, and will undoubtedly continue so. The present In 1959, Baumhoff and Heizer suggested that the sys- paper...marrow extraction and when as estimates rather than counts were insect bodies and rendering bone grease. parts (10-25%), cocoons/larvae/eggs (1-10%), and...A yielded rendering bone grease or making soup. The association of 40 burned bone fragments. A 500 ml sample from grid the unidentified fragments and

  13. Effects of Transient Power Extraction on an Integrated Hardware-in-the-Loop Aircraft/Propulsion/Power System

    DTIC Science & Technology

    2008-11-01

    Simulations of an engine and its Full Authority Digital Engine Control ( FADEC ), along with a 6 degree-of-freedom (6DoF) airframe dynamics model and...as needed. In its current configuration, the generic turbine engine model’s FADEC is included in the same simulation and runs primarily on 2 a...back to the engine. As mentioned previously, the FADEC and engine are combined into one simulation and are collectively referred to as “the engine

  14. Army Logistician. Volume 33, Issue 5, September-October 2001

    DTIC Science & Technology

    2001-10-01

    vehicle, and a first- strike ration that pro- vides an eat-out-of-hand capability for use during the initial stages of deployment, providing increased carbo...battle. On 9 September, a portion of the German 8th Army, striking though the Masurian Lakes region, severed the already anemic Rus- sian supply and...as the ability to “ strike the enemy at a time or place or in a manner for which he is unprepared.” Surprise can decisively shift the bal- ance of

  15. Electro-Optic Modulator.

    DTIC Science & Technology

    An electro - optic modulator is used to modulate coherent light beams by the application of an electric potential. It combines a Fabry-Perot etalon and...a diffraction grating in a single unit. An etalon is constructed with an electro - optic material between reflecting surfaces. A voltage applied...between alternate, spaced-apart electrodes of a metal grid attached to one reflecting surface induces a diffraction grating in the electro optic material. Light entering the etalon is diffracted, reflected and efficiently coupled out.

  16. Detailed Project Report on Emergency Shoreline Protection, Section 14 Boggy Bayou, Valparaiso, Florida

    DTIC Science & Technology

    1989-08-01

    adjacent to Bayshore Drive. Along the shoreline within the current study area, (see Plate 4) private residents have constructed three wood piers and...a wood boat shed. The construction of piers and boat sheds is no longer permitted by the city. However, the piers and boat shed were allowed to remain...located in the project site. Removal and 6 replacement of the 3 wood piers and the boat shed and the steps that lead to them will be a responsibility of

  17. Observations of Near-Bottom Flow in a Wave-Dominated Nearshore Environment.

    DTIC Science & Technology

    1994-02-01

    E 0 0 0 ~- X : (- 1.. pI m~ ffm ~o .pcr onf> ..... X • -- E X/• x,. "£ "*.. . .. . 0o 0 0 a c c ,(s0wO) (S/PH w) (SlUwo) . 7109 I 3 I Mean of LDV...1 I 8250 ASM X,ANDA #&HBF :REM 0000 OXXX ACCA 8260 ASM X,ANDB #&HBF :REM 0000 1XXX ACCB 8270 ASM X,STAB &H17 :REM /CS=0 3 8280 ASM X,STAA &H17 :REM

  18. Thermal Conductivity of Metals and Alloys at Low Temperatures. A Review of the Literature

    DTIC Science & Technology

    1954-09-01

    between OnF and Ag , Ni. anda .. er.ta.. ducovruml s f (96) .. J m Sa . Oye-rveehg odciiy.. W.1 Powe28). sample .. &...... - .3a. IM. C.. Dp..... .Je...R. KikuchiBERYLIUM (932). Cominrl See figure 2, under "Metallic Elements".. E.J. Lewi 6.0 Ag ............. k= 1.16at27WC...9 Al 2 Zn, 0.1 .71 1.32 ........................ Aged . Mo. U ~5.Cu, 0.5 Si, 0.8 Fe, 0.5 Mn, 1.23 ......................... Quenched. MIA.B

  19. Affective Intensity and its Effects

    DTIC Science & Technology

    2010-11-29

    pp174-193. Matsumoto D, Wilson J (2008). Culture , emotion, and motivation. In R. Sorrentino and S. Yamaguchi (eds.), Handbook of Motivation and...a skill which enables successful task completion. 15. SUBJECT TERMS Behavioural Science, Psychology 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...integral aspect of a person’s response to increased task  demands. Traditionally,  psychological  models have been based on verbal descriptions of the

  20. A Phase Field Model of Deformation Twinning: Nonlinear Theory and Numerical Simulations

    DTIC Science & Technology

    2011-03-01

    the system. Concepts for mod- eling multiphase systems were advanced by Steinbach et al. [3] and Steinbach and Apel [4]. Fried and Gurtin [5] and...a3b3 in a three- dimensional vector space. The outer product is (a ⊗ b) AB = aAbB. Juxtaposition implies summation over one set of adjacent indices...e.g., ( AB ) AB = AACBCB. The colon denotes summation over two sets of indices; e.g., A : B = AABBAB and (C : E) AB = CABCDECD. The transpose of amatrix is

  1. Quantal Response: Estimation and Inference

    DTIC Science & Technology

    2014-09-01

    considered. The CI-based test is just another way of looking at the Wald test. A small-sample simulation illustrates aberrant behavior of the Wald/CI...asymptotic power computation (Eq. 36) exhibits this behavior but not to such an extent as the simulated small-sample power. Sample size is n = 11 and...as |m1−m0| increases, but the power of the Wald test actually decreases for large |m1−m0| and eventually π → α . This type of behavior was reported as

  2. Using Purpose-Built Functions and Block Hashes to Enable Small Block and Sub-file Forensics

    DTIC Science & Technology

    2010-01-01

    JPEGs. We tested precarve using the nps-2009-canon2-gen6 (Garfinkel et al., 2009) disk image. The disk image was created with a 32 MB SD card and a...analysis of n-grams in the fragment. Fig. 1 e Usage of a 160 GB iPod reported by iTunes 8.2.1 (6) (top), as reported by the file system (bottom center), and...as computing with random sampling (bottom right). Note that iTunes usage actually in GiB, even though the program displays the “GB” label. Fig. 2 e

  3. Dumbing down and the Politics of Neoliberalism in Film and/as Media Studies

    ERIC Educational Resources Information Center

    Ginsberg, Terri

    2003-01-01

    Film scholars are facing widespread pressures to desist from teaching modes of analytic and theoretical discourse that were once considered important to fostering critical understandings of moving-image culture, but which have since been denigrated as either too difficult (i.e., "elitist") or too controlling (i.e., "totalizing")--or both--in the…

  4. A Prototype Silicon Compiler in Prolog

    DTIC Science & Technology

    1988-12-01

    A Prototype Silicon Compiler in Prolog 04 William Bush Gino Cheng Partrick C. McGeer Alvin M. Despain DTIC ELECTV JUL 281989 B Report No. UCB/CSD 88...the same register to variables in the same positions in invo- cation and head. Thus in ... g(A, B ),.. and g(X, Y) A and X share one register, and B ...example for a one-bit adder is given below. x = compl(or(and(c,or(a, b )),and(a, b ))). y = compl(or(and(x,or(a, b ,c)),and(a2b,c))). sum = compl(y). carry

  5. Feasibility studies for the Forward Spectrometer

    NASA Astrophysics Data System (ADS)

    Biernat, Jacek; P¯ANDA Collaboration

    2015-04-01

    The Forward Spectrometer designed for the P¯ANDA detector will consist of many different detector systems allowing for precise track reconstruction and particle identification. Feasibility studies for Forward Spectrometer done by means of specific reactions will be presented. In the first part of the paper, results of simulations focussing on rate estimates of the tracking stations based on straw tubes will be presented. Next, the importance of the Forward Tracker will be demonstrated through the reconstruction of the ψ(4040) → DD¯ decay. Finally, results from the analysis of the experimental data collected with a straw tube prototype designed and constructed at the Research Center in Juelich will be discussed.

  6. Costing Future Complex and Novel Projects

    DTIC Science & Technology

    2016-04-30

    qÜáêíÉÉåíÜ=^ååì~ä= ^Åèìáëáíáçå=oÉëÉ~êÅÜ= póãéçëáìã= qÜìêëÇ~ó=pÉëëáçåë= sçäìãÉ=ff= = Costing Future Complex & Novel Projects Michael Pryce, Centre for Defence ...Novel Projects Michael Pryce, Centre for Defence Acquisition, Cranfield University Controlling Costs: The 6-3-5 Method—Case Studies at NAVSEA and...a Lecturer in defence acquisition at Cranfield University. He teaches across a range of subjects, including the use of costing in acquisition and

  7. Recent advances in targeted endoscopic imaging: Early detection of gastrointestinal neoplasms

    PubMed Central

    Kwon, Yong-Soo; Cho, Young-Seok; Yoon, Tae-Jong; Kim, Ho-Shik; Choi, Myung-Gyu

    2012-01-01

    Molecular imaging has emerged as a new discipline in gastrointestinal endoscopy. This technology encompasses modalities that can visualize disease-specific morphological or functional tissue changes based on the molecular signature of individual cells. Molecular imaging has several advantages including minimal damage to tissues, repetitive visualization, and utility for conducting quantitative analyses. Advancements in basic science coupled with endoscopy have made early detection of gastrointestinal cancer possible. Molecular imaging during gastrointestinal endoscopy requires the development of safe biomarkers and exogenous probes to detect molecular changes in cells with high specificity anda high signal-to-background ratio. Additionally, a high-resolution endoscope with an accurate wide-field viewing capability must be developed. Targeted endoscopic imaging is expected to improve early diagnosis and individual therapy of gastrointestinal cancer. PMID:22442742

  8. The Ethics of Science and/as Research: Deconstruction and the Orientations of a New Academic Responsibility

    ERIC Educational Resources Information Center

    Trifonas, Peter

    2003-01-01

    The principle of reason "as principle of grounding, foundation or institution" has tended to guide the science of research toward techno-practical ends. From this epistemic superintendence of the terms of knowledge and inquiry, there has arisen the traditional notion of academic responsibility that is tied to the pursuit of truth via a conception…

  9. A 'college of astrology and medicine'? Charles V, Gervais Chrétien, and the scientific manuscripts of Maître Gervais's College.

    PubMed

    Boudet, Jean-Patrice

    2010-06-01

    Considered an institution mainly devoted to astrology and medicine by Simon de Phares and by some historians who believe that he was reliable, the college founded in 1371 by Charles V's first physician, Gervais Chrétien, was in fact primarily dedicated to theological students. It was not before 1377 that there were created there two bursaries for scholares regis, specialising in 'licit mathematical sciences', and two medical fellowships. Yet the influence of the activity of these fellows seems to have been rather moderate and-as far as we can learn from the material still extant, notably from manuscripts that belonged to Maître Gervais' College and to some of its members-this institution was devoted much more to theological studies than to medicine and the quadrivium.

  10. The importance of parent and child opinion in detecting change in movement capabilities.

    PubMed

    Green, Dido; Wilson, Brenda N

    2008-10-01

    Children and parents can make valid judgments about movement difficulties, which aids in the screening and assessment of Developmental Coordination Disorder (DCD). When considering therapy outcomes, child and family-centred practice supports the inclusion of parent and child perspectives to reflect progress made in meaningful daily contexts. This paper describes an evaluation of the use of questionnaires for parents and children to measure change in motor performance. Questionnaires were administered to 43 children with DCD and their parents five times over two-anda-quarter years in conjunction with other clinical measures. Parent report, using the Developmental Coordination Disorder Questionnaire, correlated significantly with clinical measures of motor skill, whilst parent and child perceptions differed. Children's confidence and resilience may influence their opinions of their ability. These results raise questions of whose perspective of progress is most valid and relevant - the therapist's, child's or parent's?

  11. Influence ofArtemisia princeps var.orientalis components on callus induction and growth.

    PubMed

    Kil, B S; Yun, K W; Lee, S Y

    1992-08-01

    An in vitro study was performed to determine the potential application of tissue culture in determining allelopathic potentialof Artemisia princeps var.Orientalis (wormwood). Aqueous extracts and volatile substances ofA. princeps var.Orientalis were tested to determine their effects on callus induction and growth of several tested species. Extracts of 5%A. princeps var.Orientalis caused some reduction in concentration, induction, and growth of callus, although they looked normal, whereas the expiants of most receptor plants did not develop callus at higher concentration. Lettuce andEclipta prostrata were the most sensitive species, andA. princeps var.Orientalis was affected by its own extracts. The growth of calluses in MS 121 medium treated with essential oil ofA. princeps var.Orientalis was inhibited, and the degree of inhibition was proportional to the concentration of the essential oil.

  12. Analysis of creatine kinase activity with evaluation of protein expression under the effect of heat and hydrogen peroxide.

    PubMed

    Rakhmetov, A D; Pil, Lee Sang; Ostapchenko, L I; Zoon, Chae Ho

    2015-01-01

    Protein oxidation has detrimental effects on the brain functioning, which involves inhibition of the crucial enzyme, brain type creatine kinase (CKBB), responsible for the CK/phosphocreatine shuttle system. Here we demonstrate a susceptibility of CKBB to several ordinary stressors. In our study enzymatic activity of purified recombinant brain-type creatine kinase was evaluated. We assayed 30 nMconcentration of CKBB under normal and stress conditions. In the direction of phosphocreatine formation hydrogen peroxide and heat treatments altered CKBB activity down to 26 and 14%, respectively. Also, examination of immunoblotted membrane patterns by SDS-PAGE electrophoresis and western blot analysis showed a decrease in expression levels of intrinsic CKBB enzyme in HeLa andA549 cells. Hence, our results clearly show that cytosolic CKBB is extremely sensitive to oxidative stress and heat induced inactivation. Therefore, due to its susceptibility, this enzyme may be defined as a potential target in brain damage.

  13. Periodic Pattern Formation of Bacterial Colonies

    NASA Astrophysics Data System (ADS)

    Itoh, Hiroto; Wakita, Jun-ichi; Matsuyama, Tohey; Matsushita, Mitsugu

    1999-04-01

    We have experimentally investigated pattern formation of colonies ofbacterial species Proteus mirabilis, which is famous forforming concentric-ring-like colonies.The colony grows cyclically with the interface repeating an advance anda stop alternately on a surface of a solid agar medium.We distinguish three phases (initial lag phase, the followingmigration and consolidation phases that appear alternately) for the colony growth.When we cut a colony just behind a migrating front shortly after the migrationstarted, the migration ended earlier and the following consolidationlasted longer.However, the following cycles were not influenced by the cut, i.e., thephases of the migration and consolidation were not affected.Global chemical signals governing the colony formation from thecenter were not found to exist.We also quantitatively checked phase entrainment by letting two coloniescollide with each other and found that it does not take place in macroscopic scales.All these experimental results suggest that the most important factorfor the migration is the cell population density.

  14. Navier-Stokes Simulation of UH-60A Rotor/Wake Interaction Using Adaptive Mesh Refinement

    NASA Technical Reports Server (NTRS)

    Chaderjian, Neal M.

    2017-01-01

    High-resolution simulations of rotor/vortex-wake interaction for a UH60-A rotor under BVI and dynamic stallconditions were carried out with the OVERFLOW Navier-Stokes code.a. The normal force and pitching moment variation with azimuth angle were in good overall agreementwith flight-test data, similar to other CFD results reported in the literature.b. The wake-grid resolution did not have a significant effect on the rotor-blade airloads. This surprisingresult indicates that a wake grid spacing of (Delta)S=10% ctip is sufficient for engineering airloads predictionfor hover and forward flight. This assumes high-resolution body grids, high-order spatial accuracy, anda hybrid RANS/DDES turbulence model.c. Three-dimensional dynamic stall was found to occur due the presence of blade-tip vortices passing overa rotor blade on the retreating side. This changed the local airfoil angle of attack, causing stall, unlikethe 2D perspective of pure pitch oscillation of the local airfoil section.

  15. Depression and diabetes distress in adults with type 2 diabetes: results from the Australian National Diabetes Audit (ANDA) 2016.

    PubMed

    Nanayakkara, Natalie; Pease, Anthony; Ranasinha, Sanjeeva; Wischer, Natalie; Andrikopoulos, Sofianos; Speight, Jane; de Courten, Barbora; Zoungas, Sophia

    2018-05-18

    This study explores the prevalence of, and factors associated with, likely depression and diabetes distress in adults with type 2 diabetes in a large, national sample. Australian National Diabetes Audit data were analysed from adults with type 2 diabetes attending 50 diabetes centres. The Brief Case find for Depression and Diabetes Distress Score 17 were administered to screen for likely depression and diabetes-related distress, respectively. A total of 2,552 adults with type 2 diabetes participated: (mean ± SD) age was 63 ± 13 years, diabetes duration was 12 ± 10 years, and HbA1c was 8 ± 2%. Twenty-nine percent of patients had likely depression, 7% had high diabetes distress, and 5% had both. Difficulty following dietary recommendations, smoking, forgetting medications, and diabetes distress were all associated with greater odds of depression whereas higher own health rating was associated with lower odds (all p < 0.02). Female gender, increasing HbA1c, insulin use, difficulty following dietary recommendations and depression were all associated with greater odds of diabetes distress & older age, higher own health rating and monitoring blood glucose levels as recommended were associated with lower odds (all p < 0.04). Depression was associated with sub-optimal self-care, while diabetes distress was associated with higher HbA1c and sub-optimal self-care.

  16. Prevention of poison ivy dermatitis with oral homeopathic Rhus toxicodendron.

    PubMed

    Signore, Robert Joseph

    2017-01-15

    Acute allergic contact dermatitis to poison ivy is acommon and miserable dermatosis which affectsmillions of Americans each year. Preventativemeasures, such as avoidance, protective clothing,barrier creams, soaps, and solvents often fail despiteour patients' best attempts. Severe allergic reactionsto poison ivy are a significant source of decreasedemployee productivity owing to inability to work anda major health care expenditure. Patients may haveto leave their jobs and discontinue favorite outdoorrecreational activities as a result of severe urushiolsensitivity. Thus, a simple and effective method ofpreventing poison ivy dermatitis would be of greatbenefit to clinical dermatologists and their patients.Complementary and alternative medical practitionerscommonly prescribe homeopathic poison ivyproducts by mouth for the prevention of poisonivy dermatitis. Yet, conventional dermatologists aremostly unaware of this little known clinical pearl. Theauthor discusses two open studies and anecdotalexperience with administration of homeopathicpoison ivy in the prevention of acute allergic contactdermatitis related to poison ivy exposure. Potentialadvantages could include patient acceptability,ease of administration, affordability, and availability.Randomized clinical trials are needed to furtherevaluate the safety and efficacy of this interesting andpromising clinical tip.

  17. Raman spectroscopic investigations on natural samples from the Integrated Ocean Drilling Program (IODP) Expedition 311: indications for heterogeneous compositions in hydrate crystals.

    PubMed

    Schicks, J M; Ziemann, M A; Lu, H; Ripmeester, J A

    2010-12-01

    Natural gas hydrates usually are found in the form of structure I, encasing predominantly methane in the hydrate lattices as guest molecules, sometimes also minor amount of higher hydrocarbons, CO2 or H2S. Raman spectroscopy is an approved tool to determine the composition of the hydrate phase. Thus, in this study Raman spectroscopic analyses have been applied to hydrate samples obtained from Integrated Ocean Drilling Program (IODP) Expedition 311 in two different approaches: studying the samples randomly taken from the hydrate core, and--as a new application--mapping small areas on the surface of clear hydrate crystals. The results obtained imply that the gas composition of hydrate, in terms of relative concentrations of CH4 and H2S, is not homogeneous over a core or even within a crystal. The mapping method yielded results with very high lateral resolution, indicating the coexistence of different phases with the same structure but different compositions within a hydrate crystal. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Pharma industry in India.

    PubMed

    Sundaram, V M

    2008-01-01

    Globally ranked fourth by volume and 13th in value, the Indian pharma industry is a leading producer of high-quality, low-cost generic drugs. Its 14% share of the USD 57 billion world generic market is expected to increase to 50% by 2010. With the advantages of cost competitiveness, ability and experience in reverse engineering, availability of skilled scientific and engineering personnel and the capability to produce raw materials for a wide range of drugs from the basic stage, the industry delivers the entire range of therapeutic products. McKinsey & Co. predict that India's pharmaceutical market could reach a size of USD 20 billion by 2015, becoming one of the top 10 drug markets in the world. Generic versions of the cardiovascular drug carvedilol, ANDA-approved allopurinol, verapamil SR and the anticancer drug paclitaxel are some of the recent products introduced by Indian companies, with Caraco, Ranbaxy, Dabur, Dr. Reddy's, Nicholas Piramal India, leading the list. Setting up of integrated drug development companies and aggressive entries into the Japanese drug market have provided further impetus to the country's pharma manufacturing arena.

  19. The 2015 Annual Meeting of SETAC German Language Branch in Zurich (7-10 September, 2015): Ecotoxicology and environmental chemistry-from research to application.

    PubMed

    Werner, Inge; Aldrich, Annette; Becker, Benjamin; Becker, Dennis; Brinkmann, Markus; Burkhardt, Michael; Caspers, Norbert; Campiche, Sophie; Chèvre, Nathalie; Düring, Rolf-Alexander; Escher, Beate I; Fischer, Fabian; Giebner, Sabrina; Heye, Katharina; Hollert, Henner; Junghans, Marion; Kienle, Cornelia; Knauer, Katja; Korkaric, Muris; Märkl, Veronika; Muncke, Jane; Oehlmann, Jörg; Reifferscheid, Georg; Rensch, Daniel; Schäffer, Andreas; Schiwy, Sabrina; Schwarz, Simon; Segner, Helmut; Simon, Eszter; Triebskorn, Rita; Vermeirssen, Etiënne L M; Wintgens, Thomas; Zennegg, Markus

    2016-01-01

    This report provides a brief review of the 20th annual meeting of the German Language Branch of the Society of Environmental Toxicology and Chemistry (SETAC GLB) held from September 7th to 10th 2015 at ETH (Swiss Technical University) in Zurich, Switzerland. The event was chaired by Inge Werner, Director of the Swiss Centre for Applied Ecotoxicology (Ecotox Centre) Eawag-EPFL, and organized by a team from Ecotox Centre, Eawag, Federal Office of the Environment, Federal Office of Agriculture, and Mesocosm GmbH (Germany). Over 200 delegates from academia, public agencies and private industry of Germany, Switzerland and Austria attended and discussed the current state of science and its application presented in 75 talks and 83 posters. In addition, three invited keynote speakers provided new insights into scientific knowledge 'brokering', and-as it was the International Year of Soil-the important role of healthy soil ecosystems. Awards were presented to young scientists for best oral and poster presentations, and for best 2014 master and doctoral theses. Program and abstracts of the meeting (mostly in German) are provided as Additional file 1.

  20. Pharmaceutical quality by design: product and process development, understanding, and control.

    PubMed

    Yu, Lawrence X

    2008-04-01

    The purpose of this paper is to discuss the pharmaceutical Quality by Design (QbD) and describe how it can be used to ensure pharmaceutical quality. The QbD was described and some of its elements identified. Process parameters and quality attributes were identified for each unit operation during manufacture of solid oral dosage forms. The use of QbD was contrasted with the evaluation of product quality by testing alone. The QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include: Defining target product quality profile; Designing product and manufacturing processes; Identifying critical quality attributes, process parameters, and sources of variability; Controlling manufacturing processes to produce consistent quality over time. Using QbD, pharmaceutical quality is assured by understanding and controlling formulation and manufacturing variables. Product testing confirms the product quality. Implementation of QbD will enable transformation of the chemistry, manufacturing, and controls (CMC) review of abbreviated new drug applications (ANDAs) into a science-based pharmaceutical quality assessment.

  1. Burden of cardiovascular risk factors and disease among patients with type 1 diabetes: results of the Australian National Diabetes Audit (ANDA).

    PubMed

    Pease, Anthony; Earnest, Arul; Ranasinha, Sanjeeva; Nanayakkara, Natalie; Liew, Danny; Wischer, Natalie; Andrikopoulos, Sofianos; Zoungas, Sophia

    2018-06-02

    Cardiovascular risk stratification is complex in type 1 diabetes. We hypothesised that traditional and diabetes-specific cardiovascular risk factors were prevalent and strongly associated with cardiovascular disease (CVD) among adults with type 1 diabetes attending Australian diabetes centres. De-identified, prospectively collected data from patients with type 1 diabetes aged ≥ 18 years in the 2015 Australian National Diabetes Audit were analysed. The burden of cardiovascular risk factors [age, sex, diabetes duration, glycated haemoglobin (HbA1c), blood pressure, lipid profile, body mass index, smoking status, retinopathy, renal function and albuminuria] and associations with CVD inclusive of stroke, myocardial infarction, coronary artery bypass graft surgery/angioplasty and peripheral vascular disease were assessed. Restricted cubic splines assessed for non-linearity of diabetes duration and likelihood ratio test assessed for interactions between age, diabetes duration, centre type and cardiovascular outcomes of interest. Discriminatory ability of multivariable models were assessed with area under the receiver operating characteristic (ROC) curves. Data from 1169 patients were analysed. Mean (± SD) age and median diabetes duration was 40.0 (± 16.7) and 16.0 (8.0-27.0) years respectively. Cardiovascular risk factors were prevalent including hypertension (21.9%), dyslipidaemia (89.4%), overweight/obesity (56.4%), ever smoking (38.5%), albuminuria (31.1%), estimated glomerular filtration rate < 60 mL/min/1.73 m 2 (10.3%) and HbA1c > 7.0% (53 mmol/mol) (81.0%). Older age, longer diabetes duration, smoking and antihypertensive therapy use were positively associated with CVD, while high density lipoprotein-cholesterol and diastolic blood pressure were negatively associated (p < 0.05). Association with CVD and diabetes duration remained constant until 20 years when a linear increase was noted. Longer diabetes duration also had the highest population attributable risk of 6.5% (95% CI 1.4, 11.6). Further, the models for CVD demonstrated good discriminatory ability (area under the ROC curve 0.88; 95% CI 0.84, 0.92). Cardiovascular risk factors were prevalent and strongly associated with CVD among adults with type 1 diabetes attending Australian diabetes centres. Given the approximate J-shaped association between type 1 diabetes duration and CVD, the impact of cardiovascular risk stratification and management before and after 20 years duration needs to be further assessed longitudinally. Diabetes specific cardiovascular risk stratification tools incorporating diabetes duration should be an important consideration in future guideline development.

  2. FDA's proposed rules on patent listing requirements for new drug and 30-month stays on ANDA approval (proposed Oct. 24, 2002).

    PubMed

    Hui, Yuk Fung

    2003-01-01

    In order to close the loophole in the generic drug approval process that allows a brand name drug patent holder to delay or defeat generic drug application merely by technicality, the FDA recently proposed to modify its regulations. Those proposals affect the patent listing requirements of a new drug application, and the duration of time that a generic drug application could be put on hold in the event of a patent infringement suit. With the modified rules, the FDA expects to see an increase in the availability of generic drugs, which eventually will lead to lower drug costs. Ms. Hui discusses the contents of the proposed regulations and provides an analysis of the proposed rule's legal authority, implications on patent rights, and impact on the pharmaceutical industry.

  3. Approaches for the Application of Physiologically Based ...

    EPA Pesticide Factsheets

    This draft report of Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment addresses the application and evaluation of PBPK models for risk assessment purposes. These models represent an important class of dosimetry models that are useful for predicting internal dose at target organs for risk assessment applications. Topics covered include:the types of data required use of PBPK models in risk assessment,evaluation of PBPK models for use in risk assessment, andthe application of these models to address uncertainties resulting from extrapolations (e.g. interspecies extrapolation) often used in risk assessment.In addition, appendices are provided that includea compilation of chemical partition coefficients and rate constants,algorithms for estimating chemical-specific parameters, anda list of publications relating to PBPK modeling. This report is primarily meant to serve as a learning tool for EPA scientists and risk assessors who may be less familiar with the field. In addition, this report can be informative to PBPK modelers within and outside the Agency, as it provides an assessment of the types of data and models that the EPA requires for consideration of a model for use in risk assessment.

  4. Generic Pharmaceutical Association (GPhA) - 2015 CMC Workshop (June 9-10, 2015 - Bethesda, Maryland, USA).

    PubMed

    Komlos, D

    2015-07-01

    Nearly 400 professionals attended the 2-day Generic Pharmaceutical Association (GPhA) workshop dedicated to fostering discussions on the FDA's chemistry, manufacturing and controls (CMC) expectations for abbreviated new drug applications (ANDAs), enhanced regulatory filing requirements, and other topics, as CMC takes root in the Office of Pharmaceutical Quality (OPQ). Following the keynote address by Janet Woodcock, Director of the FDA's Center for Drug Evaluation and Research (CDER) and Acting Director of OPQ, and an update from the Office of Generic Drugs (OGD) by Ted Sherwood, Acting Director of the OGD's Office of Regulatory Operations, plenary sessions took place covering OPQ updates, management plans, Generic Drug User Fee Amendments of 2012 (GDUFA) backlog, year 1 and 2 cohorts, drug substance, defining starting materials, quality related refuse-to-receive standards, risk and team-based integrated quality assessment, deficiencies and information requests - CMC submissions, emerging technologies, compliance and inspection, lifecycle management of drug products, quality metrics, pharmaceutically relevant dissolution specifications, and communication and project management. This report will provide a summary of conference highlights. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

  5. Wigs, laughter, and subversion: Charles Busch and strategies of drag performance.

    PubMed

    Niles, Richard

    2004-01-01

    This paper examines the strategies of drag performer/ playwright Charles Busch. His performance aesthetic is explored and shown to be subversive even though its initial impulse is to entertain. Basing my arguments on the work of Judith Butler, Elin Diamond, and others, I argue that drag queens like Busch can not only entertain but also make audiences question and criticize through drag's power to create a Brechtian alienation effect and historicize the subject. After showing how he can be viewed as a drag queen, I give a brief biography and discuss such contested terms as "camp" and "gay sensibility." I then focus on Busch's staged reading of Ibsen's Hedda Gahler andA Doll's House, both done in one afternoon at Theatre for The New City (6 May 2000). By examining the performance of Busch and his fellow actors, I demonstrate how a contemporary relevancy is achieved by having the roles played by a female impersonator whose acting choices are filtered through a gay sensibility. The ongoing dialectic between spectator and performer creates a historicized moment in performance that underscores the gender dynamics in unexpected and stimulating ways.

  6. Liquid Drop Model for Charged Spherical Metal Clusters

    NASA Astrophysics Data System (ADS)

    Seidl, M.; Brack, M.

    1996-02-01

    The average ground-state energy of a charged spherical metal cluster withNatoms andzexcessive valence electrons, i.e., with net chargeQ=-ezand radiusR=rsN1/3, is presented in the liquid drop model (LDM) expansionE(N, z)=avN+asN2/3+acN1/3+a0(z)+a-1(z) N-1/3+O(N-2/3). We derive analytical expressions for the leading LDM coefficientsav,as,ac, and, in particular, for the charge dependence of the further LDM coefficientsa0anda-1, using the jellium model and density functional theory in the local density approximation. We obtain for the ionization energyI(R)=W+α(e2/R)+O(R-2), with the bulk work functionW=[Φ(+∞)-Φ(0)]-eb, given first by Mahan and Schaich in terms of the electrostatic potentialΦand the bulk energy per electroneb, and a new analytical expression for the dimensionless coefficientα. We demonstrate that within classical theoryα={1}/{2} but, in agreement with experimental information,αtends to ∼0.4 if quantum-mechanical contributions are included. In order to test and confirm our analytical expressions, we discuss the numerical results of semiclassical density variational calculations in the extended Thomas-Fermi model.

  7. MIDI face-lift and tricuspidal SMAS-flap.

    PubMed

    Panfilov, Dimitrije E

    2003-01-01

    Looking tired is enough for many 40-50-years-olds to ask a plastic surgeon for prophylactic rejuvenation. They want to achieve good and long lasting effects with harmonious features, small scars, and--as they are still very active in their professional and private lives--a quick recovery is very important to them. We have developed a modification of the short-scar face-lift with solid deep support. We call it the MIDI face-lift. MIDI stands for Minimal, Invasive, Deep, Intensive. Technical details are as follows. Two half Z-plasties were performed at each end of modest skin excision, supra-auriculary and retro-auriculary, to avoid even suture edges. By doing so we achieve very unobtrusive scarring. For solid SMAS tension we perform SMAS-plication, simple SMAS-flap, or tricuspidal SMAS-flap. This is an overview of 200 patients we treated over three years. By applying tumescent local anesthesia with adrenaline and ornipressin, and fibrin glue at the end of the procedure, we can the draining so that 96% of our patients were outpatients. Technical details will be discussed as well as complications, adjuvant and alternative procedures. The satisfaction of our patients was high (88%) and no major complications have occurred. Only three out of 200 patients had to undergo revisionary surgery.

  8. Supply determines demand: influence of partner quality and quantity on the interactions between bats and pitcher plants.

    PubMed

    Schöner, Caroline R; Schöner, Michael G; Kerth, Gerald; Grafe, T Ulmar

    2013-09-01

    Interspecific relationships such as mutualism and parasitism are major drivers of biodiversity. Because such interactions often comprise more than two species, ecological studies increasingly focus on complex multispecies systems. However, the spatial heterogeneity of multi-species interactions is often poorly understood. Here, we investigate the unusual interaction of a bat (Kerivoula hardwickii hardwickii) and two pitcher plant species (Nepenthes hemsleyana and N. bicalcarata) whose pitchers serve as roost for bats. Nepenthes hemsleyana offers roosts of higher quality, indicated by a more stable microclimate compared to N. bicalcarata but occurs at lower abundance and is less common than the latter. Whereas N. hemsleyana benefits from the roosting bats by gaining nitrogen from their feces, the bats' interaction with N. bicalcarata seems to be commensal or even parasitic. Bats stayed longer in roosts of higher quality provided by N. hemsleyana and preferred them to pitchers of N. bicalcarata in a disturbance experiment. Moreover, bats roosting only in pitchers of N. hemsleyana had a higher body condition and were less infested with parasites compared to bats roosting in pitchers of N. bicalcarata. Our study shows how the local supply of roosts with different qualities affects the behavior and status of their inhabitants and-as a consequence-how the demand of the inhabitants can influence evolutionary adaptations of the roost providing species.

  9. Ethnopharmacological studies on the uses of Euphorbia hirta in the treatment of dengue in selected indigenous communities in Pangasinan (Philippines)

    PubMed Central

    de Guzman, Gerard Quinto; Dacanay, Aleth Therese Lora; Andaya, Benjel Andaya; Alejandro, Grecebio Jonathan Duran

    2016-01-01

    Aim: Euphorbia hirta is the most widely used plant in the folkloric treatment of dengue in the Philippines. This study documents the anecdotal uses of E. hirta in the treatment of dengue in 3 indigenous communities in Pangasinan from April to June of 2015. Materials and Methods: The number of use reports pertaining to symptoms of dengue and other diseases were tallied from 82 informants living in Anda Island, Mt. Colisao and Mt. Balungao. The demographics of the informants as well as the corrected major use agreements (cMUAs) and fidelity levels (FLs) of each reported symptom of dengue were calculated. The major dosage forms used during treatment were also tallied. Results: Respondents, dominated by the age group 60-80 and mostly females with at least primary and secondary education, provided information on the use reports of E. hirta. High FL values and cMUA of at least 35% were obtained for cardinal symptoms of dengue-related to bleeding episodes while low cMUAs (i.e. 2-4%) were obtained for symptoms during the recovery phase. High FL values were obtained for symptoms observed during the febrile phase. The most widely used dosage forms are decoctions of the leaves and barks of E. hirta. Conclusion: This study was able to qualify the uses of E. hirta in the treatment of dengue in the 3 communities surveyed. PMID:27366349

  10. Abstinence-Only-Until-Marriage: An Updated Review of U.S. Policies and Programs and Their Impact.

    PubMed

    Santelli, John S; Kantor, Leslie M; Grilo, Stephanie A; Speizer, Ilene S; Lindberg, Laura D; Heitel, Jennifer; Schalet, Amy T; Lyon, Maureen E; Mason-Jones, Amanda J; McGovern, Terry; Heck, Craig J; Rogers, Jennifer; Ott, Mary A

    2017-09-01

    Adolescence is marked by the emergence of human sexuality, sexual identity, and the initiation of intimate relations; within this context, abstinence from sexual intercourse can be a healthy choice. However, programs that promote abstinence-only-until-marriage (AOUM) or sexual risk avoidance are scientifically and ethically problematic and-as such-have been widely rejected by medical and public health professionals. Although abstinence is theoretically effective, in actual practice, intentions to abstain from sexual activity often fail. Given a rising age at first marriage around the world, a rapidly declining percentage of young people remain abstinent until marriage. Promotion of AOUM policies by the U.S. government has undermined sexuality education in the United States and in U.S. foreign aid programs; funding for AOUM continues in the United States. The weight of scientific evidence finds that AOUM programs are not effective in delaying initiation of sexual intercourse or changing other sexual risk behaviors. AOUM programs, as defined by U.S. federal funding requirements, inherently withhold information about human sexuality and may provide medically inaccurate and stigmatizing information. Thus, AOUM programs threaten fundamental human rights to health, information, and life. Young people need access to accurate and comprehensive sexual health information to protect their health and lives. Copyright © 2017 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  11. A hierarchical wavefront reconstruction algorithm for gradient sensors

    NASA Astrophysics Data System (ADS)

    Bharmal, Nazim; Bitenc, Urban; Basden, Alastair; Myers, Richard

    2013-12-01

    ELT-scale extreme adaptive optics systems will require new approaches tocompute the wavefront suitably quickly, when the computational burden ofapplying a MVM is no longer practical. An approach is demonstrated here whichis hierarchical in transforming wavefront slopes from a WFS into a wavefront,and then to actuator values. First, simple integration in 1D is used to create1D-wavefront estimates with unknown starting points at the edges of independentspatial domains. Second, these starting points are estimated globally. By thesestarting points are a sub-set of the overall grid where wavefront values are tobe estimated, sparse representations are produced and numerical complexity canbe chosen by the spacing of the starting point grid relative to the overallgrid. Using a combination of algebraic expressions, sparse representation, anda conjugate gradient solver, the number of non-parallelized operations forreconstruction on a 100x100 sub-aperture sized problem is ~600,000 or O(N^3/2),which is approximately the same as for each thread of a MVM solutionparallelized over 100 threads. To reduce the effects of noise propagationwithin each domain, a noise reduction algorithm can be applied which ensuresthe continuity of the wavefront. To apply this additional step has a cost of~1,200,000 operations. We conclude by briefly discussing how the final step ofconverting from wavefront to actuator values can be achieved.

  12. [Transciptome among Mexicans: a large scale methodology to analyze the genetics expression profile of simultaneous samples in muscle, adipose tissue and lymphocytes obtained from the same individual].

    PubMed

    Bastarrachea, Raúl A; López-Alvarenga, Juan Carlos; Kent, Jack W; Laviada-Molina, Hugo A; Cerda-Flores, Ricardo M; Calderón-Garcidueñas, Ana Laura; Torres-Salazar, Amada; Torres-Salazar, Amanda; Nava-González, Edna J; Solis-Pérez, Elizabeth; Gallegos-Cabrales, Esther C; Cole, Shelley A; Comuzzie, Anthony G

    2008-01-01

    We describe the methodology used to analyze multiple transcripts using microarray techniques in simultaneous biopsies of muscle, adipose tissue and lymphocytes obtained from the same individual as part of the standard protocol of the Genetics of Metabolic Diseases in Mexico: GEMM Family Study. We recruited 4 healthy male subjects with BM1 20-41, who signed an informed consent letter. Subjects participated in a clinical examination that included anthropometric and body composition measurements, muscle biopsies (vastus lateralis) subcutaneous fat biopsies anda blood draw. All samples provided sufficient amplified RNA for microarray analysis. Total RNA was extracted from the biopsy samples and amplified for analysis. Of the 48,687 transcript targets queried, 39.4% were detectable in a least one of the studied tissues. Leptin was not detectable in lymphocytes, weakly expressed in muscle, but overexpressed and highly correlated with BMI in subcutaneous fat. Another example was GLUT4, which was detectable only in muscle and not correlated with BMI. Expression level concordance was 0.7 (p< 0.001) for the three tissues studied. We demonstrated the feasibility of carrying out simultaneous analysis of gene expression in multiple tissues, concordance of genetic expression in different tissues, and obtained confidence that this method corroborates the expected biological relationships among LEPand GLUT4. TheGEMM study will provide a broad and valuable overview on metabolic diseases, including obesity and type 2 diabetes.

  13. The effect of acupuncture treatment for insomnia in chronic hemodialysis patients

    NASA Astrophysics Data System (ADS)

    Widjaja, J. A.; Simadibrata, C.; Srilestari, A.; Marbun, M. B. H.

    2017-08-01

    Insomnia is a problem often experienced by patients on chronic dialysiswhich reduces their quality of life. Current management of insomnia with this specific group of patients has yet to produce optimum results. In this study, we explored the roleof acupuncture as a treatment for symptoms of insomnia in patients on chronic dialysis. Twenty-eight hemodialysis patients suffering from insomnia were divided randomly into two groups, an acupuncture group (n = 15) who received acupuncture treatment at the points HT7 Shenmen, PC6 Neiguan, GV20 Baihui, and EX-HN1 Sishenchong, anda control group (n = 13) who underwenta sham procedure in which a needle was inserted into an elastic bandage at the same points. The acupuncture treatment was done during hemodialysis twice a week for five weeks. PSQI scores and the WHOQOL-BREF were assessed before treatment, after the fifth treatment, and at the end of the treatment. Significant differences were found in the PSQI score ((4.20±2.27 vs. 11.23±3.37) p = 0.000) and in the WHOQOL-BREF ((94.53±10.08 vs. 82.69±11.90) p = 0.008) between the acupuncture group and the control group by the end of the period of treatment. Acupuncture treatment effectively improved the quality of sleep and the quality of life for these chronic hemodialysis patients.

  14. Argyres–Douglas theories, S 1 reductions, and topological symmetries

    DOE PAGES

    Buican, Matthew; Nishinaka, Takahiro

    2015-12-21

    In a recent paper, we proposed closed-form expressions for the superconformal indices of the (A(1), A(2n-3)) and(A(1), D-2n) Argyres-Douglas (AD) superconformal field theories (SCFTs) in the Schur limit. Following up on our results, we turn our attention to the small S-1 regime of these indices. As expected on general grounds, our study reproduces the S-3 partition functions of the resulting dimensionally reduced theories. However, we show that in all cases-with the exception of the reduction of the (A(1), D-4) SCFTcertain imaginary partners of real mass terms are turned on in the corresponding mirror theories. We interpret these deformations as Rmore » symmetry mixing with the topological symmetries of the direct S-1 reductions. Moreover, we argue that these shifts occur in any of our theories whose four-dimensional N = 2 superconformal U(1)(R) symmetry does not obey an SU(2) quantization condition. We then use our R symmetry map to find the fourdimensional ancestors of certain three-dimensional operators. Somewhat surprisingly, this picture turns out to imply that the scaling dimensions of many of the chiral operators of the four-dimensional theory are encoded in accidental symmetries of the three-dimensional theory. We also comment on the implications of our work on the space of general N = 2 SCFTs.« less

  15. Argyres–Douglas theories, S 1 reductions, and topological symmetries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buican, Matthew; Nishinaka, Takahiro

    In a recent paper, we proposed closed-form expressions for the superconformal indices of the (A(1), A(2n-3)) and(A(1), D-2n) Argyres-Douglas (AD) superconformal field theories (SCFTs) in the Schur limit. Following up on our results, we turn our attention to the small S-1 regime of these indices. As expected on general grounds, our study reproduces the S-3 partition functions of the resulting dimensionally reduced theories. However, we show that in all cases-with the exception of the reduction of the (A(1), D-4) SCFTcertain imaginary partners of real mass terms are turned on in the corresponding mirror theories. We interpret these deformations as Rmore » symmetry mixing with the topological symmetries of the direct S-1 reductions. Moreover, we argue that these shifts occur in any of our theories whose four-dimensional N = 2 superconformal U(1)(R) symmetry does not obey an SU(2) quantization condition. We then use our R symmetry map to find the fourdimensional ancestors of certain three-dimensional operators. Somewhat surprisingly, this picture turns out to imply that the scaling dimensions of many of the chiral operators of the four-dimensional theory are encoded in accidental symmetries of the three-dimensional theory. We also comment on the implications of our work on the space of general N = 2 SCFTs.« less

  16. Structure determination of two structural analogs, named 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16F2N4S) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) by synchrotron X-ray powder diffraction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gündoğdu, Gülsüm; Aytaç, Sevim Peri; Müller, Melanie

    Two novel compounds, 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C 23H 16F 2N 4S) (1) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C 23H 16ClFN 4S) (2), have been designed and synthesized as cytotoxic agents. The compounds were characterized by infrared, proton nuclear magnetic resonance, mass spectral data, elemental analysis and X-ray powder diffraction. The present study comprises spectral data and crystal structures of these novel compounds determined from synchrotron X-ray powder diffraction data. The structure solutions were obtained by simulated annealing. The final structures were achieved by Rietveld refinement using soft restraints for all bond lengths, bond angles, and planar groups. Both compounds crystallize in space groupmore » $$P\\bar 1$$,Z= 2, with the unit-cell parametersa= 6.37433(9),b= 11.3641(2),c= 14.09115(19) Å,α= 80.1740(8)°,β= 85.1164(8)°,γ= 80.9831(10)°,V= 991.55(3) Å 3of compound (1) anda= 6.53736(6),b= 11.55725(15),c= 14.01373(13) Å,α= 80.3323(7)°,β= 84.8939(6)°,γ= 79.3954(8)°,V= 1024.08(2) Å 3of compound (2). Structural analyses reveal that the title compounds are isostructural.« less

  17. The Role of Regulatory Agencies and Intellectual Property: Part II

    PubMed Central

    Noonan, Kevin E.

    2015-01-01

    Patent law and antitrust law have traditionally been areas of the law involving at least some inherent tension. Champions of antitrust argue that the patent “monopoly” must be strictly limited as an exception to the general legal principle that competition should be unfettered. Patent lawyers argue that patents are the result of an exercise of congressional authority, enshrined in the Constitution, reflecting the policy decision by the Founders that granting a limited exclusionary right was justified by the public benefits derived from full disclosure of the patented invention. In the modern era these competing values have played out in the context of so-called ANDA litigation, involving disputes between branded pharmaceutical companies and generic competitors. Settlement of such litigation has been identified by the Federal Trade Commission (FTC), and private parties encouraged by the FTC’s position, as an antitrust violation, in large part because such settlements are viewed as frustrating the congressional purpose in promoting early generic competition. After almost a decade of fighting these battles in the federal courts, the Supreme Court addressed the issue directly. The result is that such settlements are not per se illegal but are also not protected by the presumption of patent validity for activities within the “scope of the patent.” Rather, the court decided that these agreements should be assessed for antitrust liability under the “rule of reason” used in other antitrust contexts. PMID:25775920

  18. The Role of Regulatory Agencies and Intellectual Property: Part II.

    PubMed

    Noonan, Kevin E

    2015-03-16

    Patent law and antitrust law have traditionally been areas of the law involving at least some inherent tension. Champions of antitrust argue that the patent "monopoly" must be strictly limited as an exception to the general legal principle that competition should be unfettered. Patent lawyers argue that patents are the result of an exercise of congressional authority, enshrined in the Constitution, reflecting the policy decision by the Founders that granting a limited exclusionary right was justified by the public benefits derived from full disclosure of the patented invention. In the modern era these competing values have played out in the context of so-called ANDA litigation, involving disputes between branded pharmaceutical companies and generic competitors. Settlement of such litigation has been identified by the Federal Trade Commission (FTC), and private parties encouraged by the FTC's position, as an antitrust violation, in large part because such settlements are viewed as frustrating the congressional purpose in promoting early generic competition. After almost a decade of fighting these battles in the federal courts, the Supreme Court addressed the issue directly. The result is that such settlements are not per se illegal but are also not protected by the presumption of patent validity for activities within the "scope of the patent." Rather, the court decided that these agreements should be assessed for antitrust liability under the "rule of reason" used in other antitrust contexts. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

  19. An Assessment of Concerns Regarding New Regulatory Guidance for Combination Products: A Review of the Submissions Made to the FDA Regarding Their Proposed Draft New Guidance on Human Factors Studies for a Combination Product in an Abbreviated New Drug Application.

    PubMed

    Lance, Philip T; Greenaway, Ruth V; Edwards, Brian

    2018-01-01

    The US Food and Drug Administration (FDA) put out a call for comments on new draft guidance for industry "Comparative Analyses and Related Comparative Use Human Factors Studies for a Drug-Device Combination Product Submitted in an ANDA." This call for comments elicited 7 submissions from various organizations in the field of health care products. This article reports on a review conducted on these 7 submissions. The purpose of this review was to identify any commonalities across the different submissions and determine if there was consensus on any point or aspect of the draft guidance. To identify any commonalities, a heat map plotting the lines of the draft guidance that had raised a comment/suggestion was produced. Also, a thematic analysis was conducted on the comments/suggestions. In total the 7 submissions produced 137 suggestions. The heat map revealed that these suggestions did not focus on any single part of the guidance but were spread throughout the guidance. The thematic analysis conducted on the suggestions found a number of distinct trends. These trends were grouped into 10 primary themes, each with a number of subthemes. It was concluded that guidance from the FDA on this matter is warranted and would be appreciated. However, it was also concluded that based on the distinct trends identified in the suggestions, there are issues that the FDA may wish to consider before publishing their final guidance.

  20. Liposomal Drug Product Development and Quality: Current US Experience and Perspective.

    PubMed

    Kapoor, Mamta; Lee, Sau L; Tyner, Katherine M

    2017-05-01

    Research in the area of liposomes has grown substantially in the past few decades. Liposomes are lipid bilayer structures that can incorporate drug substances to modify the drug's pharmacokinetic profile thereby improving drug delivery. The agency has received over 400 liposomal drug product submissions (excluding combination therapies), and there are currently eight approved liposomal drug products on the US market. In order to identify the pain points in development and manufacturing of liposomal drug products, a retrospective analysis was performed from a quality perspective on submissions for new and generic liposomal drug products. General analysis on liposomal drug product submissions was also performed. Results indicated that 96% of the submissions were Investigational New Drug (IND) applications, 3% were New Drug Applications (NDAs), and the remaining 1% was Abbreviated New Drug Applications (ANDAs). Doxorubicin hydrochloride was the most commonly used drug substance incorporated into the liposomes (31%). The majority of the liposomal products were administered via intravenous route (84%) with cancer (various types) being the most common indication (63%). From a quality perspective, major challenges during the development of liposomal drug products included identification and (appropriate) characterization of critical quality attributes of liposomal drug products and suitable control strategies during product development. By focusing on these areas, a faster and more efficient development of liposomal drug products may be achieved. Additionally, in this way, the drug review process for such products can be streamlined.

  1. Histogram Profiling of Postcontrast T1-Weighted MRI Gives Valuable Insights into Tumor Biology and Enables Prediction of Growth Kinetics and Prognosis in Meningiomas.

    PubMed

    Gihr, Georg Alexander; Horvath-Rizea, Diana; Kohlhof-Meinecke, Patricia; Ganslandt, Oliver; Henkes, Hans; Richter, Cindy; Hoffmann, Karl-Titus; Surov, Alexey; Schob, Stefan

    2018-06-14

    Meningiomas are the most frequently diagnosed intracranial masses, oftentimes requiring surgery. Especially procedure-related morbidity can be substantial, particularly in elderly patients. Hence, reliable imaging modalities enabling pretherapeutic prediction of tumor grade, growth kinetic, realistic prognosis, and-as a consequence-necessity of surgery are of great value. In this context, a promising diagnostic approach is advanced analysis of magnetic resonance imaging data. Therefore, our study investigated whether histogram profiling of routinely acquired postcontrast T1-weighted images is capable of separating low-grade from high-grade lesions and whether histogram parameters reflect Ki-67 expression in meningiomas. Pretreatment T1-weighted postcontrast volumes of 44 meningioma patients were used for signal intensity histogram profiling. WHO grade, tumor volume, and Ki-67 expression were evaluated. Comparative and correlative statistics investigating the association between histogram profile parameters and neuropathology were performed. None of the investigated histogram parameters revealed significant differences between low-grade and high-grade meningiomas. However, significant correlations were identified between Ki-67 and the histogram parameters skewness and entropy as well as between entropy and tumor volume. Contrary to previously reported findings, pretherapeutic postcontrast T1-weighted images can be used to predict growth kinetics in meningiomas if whole tumor histogram analysis is employed. However, no differences between distinct WHO grades were identifiable in out cohort. As a consequence, histogram analysis of postcontrast T1-weighted images is a promising approach to obtain quantitative in vivo biomarkers reflecting the proliferative potential in meningiomas. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Comparative evaluation of in vitro efficacy of colesevelam hydrochloride tablets.

    PubMed

    Krishnaiah, Yellela S R; Yang, Yongsheng; Bykadi, Srikant; Sayeed, Vilayat A; Khan, Mansoor A

    2014-09-01

    Colesevelam hydrochloride is used as an adjunct to diet and exercise to reduce elevated low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia as well as to improve glycemic control in patients with type 2 diabetes. This is likely to result in submission of abbreviated new drug applications (ANDA). This study was conducted to compare the efficacy of two tablet products of colesevelam hydrochloride based on the in vitro binding of bile acid sodium salts of glycocholic acid (GC), glycochenodeoxycholic acid (GCDA) and taurodeoxycholic acid (TDCA). Kinetic binding study was carried out with constant initial bile salt concentrations as a function of time. Equilibrium binding studies were conducted under conditions of constant incubation time and varying initial concentrations of bile acid sodium salts. The unbound concentration of bile salts was determined in the samples of these studies. Langmuir equation was utilized to calculate the binding constants k1 and k2. The amount of the three bile salts bound to both the products reached equilibrium at 3 h. The similarity factor (f2) was 99.5 based on the binding profile of total bile salts to the test and reference colesevelam tablets as a function of time. The 90% confidence interval for the test to reference ratio of k2 values were 96.06-112.07 which is within the acceptance criteria of 80-120%. It is concluded from the results that the test and reference tablets of colesevelam hydrochloride showed a similar in vitro binding profile and capacity to bile salts.

  3. The mitochondrial genomes of Amphiascoides atopus and Schizopera knabeni (Harpacticoida: Miraciidae) reveal similarities between the copepod orders Harpacticoida and Poecilostomatoida.

    PubMed

    Easton, Erin E; Darrow, Emily M; Spears, Trisha; Thistle, David

    2014-03-15

    Members of subclass Copepoda are abundant, diverse, and-as a result of their variety of ecological roles in marine and freshwater environments-important, but their phylogenetic interrelationships are unclear. Recent studies of arthropods have used gene arrangements in the mitochondrial (mt) genome to infer phylogenies, but for copepods, only seven complete mt genomes have been published. These data revealed several within-order and few among-order similarities. To increase the data available for comparisons, we sequenced the complete mt genome (13,831base pairs) of Amphiascoides atopus and 10,649base pairs of the mt genome of Schizopera knabeni (both in the family Miraciidae of the order Harpacticoida). Comparison of our data to those for Tigriopus japonicus (family Harpacticidae, order Harpacticoida) revealed similarities in gene arrangement among these three species that were consistent with those found within and among families of other copepod orders. Comparison of the mt genomes of our species with those known from other copepod orders revealed the arrangement of mt genes of our Harpacticoida species to be more similar to that of Sinergasilus polycolpus (order Poecilostomatoida) than to that of T. japonicus. The similarities between S. polycolpus and our species are the first to be noted across the boundaries of copepod orders and support the possibility that mt-gene arrangement might be used to infer copepod phylogenies. We also found that our two species had extremely truncated transfer RNAs and that gene overlaps occurred much more frequently than has been reported for other copepod mt genomes. Published by Elsevier B.V.

  4. Algicidal effects of four Chinese herb extracts on bloom-forming Microcystis aeruginosa and Chlorella pyrenoidosa.

    PubMed

    Ye, Liangtao; Qian, Jiazhong; Jin, Song; Zuo, Shengpeng; Mei, Hui; Ma, Suming

    2014-01-01

    Extracts from four Chinese herbs, Phellodendri chinensis cortex, Artemisia annua L., Scutellaria baicalensis G. and Citrus reticulate peel were tested for their algicidal effects on Microcystis aeruginosa and Chlorella pyrenoidosa. The results showed that M. aeruginosa was more susceptible than C. pyrenoidosa. The growth of M. aeruginosa was significantly inhibited (p < 0.05) by the four herb extracts. Among the four herbs, P. chinensis cortex and S. baicalensis had the greatest inhibitory effects on M. aeruginosa, followed by C reticulate peel and A. annua. The 50% effective concentrations (EC50) of S. baicalensis, P chinensis cortex, C. reticulate peel and A. annua were 0.87, 0.88, 5.27 and 1 1.16 gherb L-1, respectively. The growth of C. pyrenoidosa was moderately inhibited by the herb extracts individually. The EC5o concentrations for S. baicalensis, P. chinensis cortex, C. reticulate peel andA. annua were 8.67, 11.67, 12.81 and 12.44 g herb L-1', respectively. Extract from S. baicalensis displayed stronger algicidal effects on C. pyrenoidosa than the other three herbs, although no lethal effect on C. pyrenoidosa was observed during the cultivation period. Compared with corresponding individual extract at the same dosage, the binary mixtures of the four herb extracts enhanced the algicidal effects on M. aeruginosa. The maximum inhibitory rates of all binary mixtures of the four herb extracts were all above 92% during the 10-day incubation. The results demonstrate that Chinese herbs, such as P. chinensis cortex or S. baicalensis and their combinations, could offer an effective alternative for mitigating outbreaks of harmful algal blooms in water bodies.

  5. Development of coherent neuronal activity patterns in mammalian cortical networks: common principles and local hetereogeneity.

    PubMed

    Egorov, Alexei V; Draguhn, Andreas

    2013-01-01

    Many mammals are born in a very immature state and develop their rich repertoire of behavioral and cognitive functions postnatally. This development goes in parallel with changes in the anatomical and functional organization of cortical structures which are involved in most complex activities. The emerging spatiotemporal activity patterns in multi-neuronal cortical networks may indeed form a direct neuronal correlate of systemic functions like perception, sensorimotor integration, decision making or memory formation. During recent years, several studies--mostly in rodents--have shed light on the ontogenesis of such highly organized patterns of network activity. While each local network has its own peculiar properties, some general rules can be derived. We therefore review and compare data from the developing hippocampus, neocortex and--as an intermediate region--entorhinal cortex. All cortices seem to follow a characteristic sequence starting with uncorrelated activity in uncoupled single neurons where transient activity seems to have mostly trophic effects. In rodents, before and shortly after birth, cortical networks develop weakly coordinated multineuronal discharges which have been termed synchronous plateau assemblies (SPAs). While these patterns rely mostly on electrical coupling by gap junctions, the subsequent increase in number and maturation of chemical synapses leads to the generation of large-scale coherent discharges. These patterns have been termed giant depolarizing potentials (GDPs) for predominantly GABA-induced events or early network oscillations (ENOs) for mostly glutamatergic bursts, respectively. During the third to fourth postnatal week, cortical areas reach their final activity patterns with distinct network oscillations and highly specific neuronal discharge sequences which support adult behavior. While some of the mechanisms underlying maturation of network activity have been elucidated much work remains to be done in order to fully

  6. Detection of Ehrlichia spp., Anaplasma spp., Rickettsia spp., and other eubacteria in ticks from the Thai-Myanmar border and Vietnam.

    PubMed

    Parola, Philippe; Cornet, Jean-Paul; Sanogo, Yibayiri Osée; Miller, R Scott; Thien, Huynh Van; Gonzalez, Jean-Paul; Raoult, Didier; Telford III, Sam R; Wongsrichanalai, Chansuda

    2003-04-01

    A total of 650 ticks, including 13 species from five genera, were collected from animals, from people, or by flagging of the vegetation at sites on the Thai-Myanmar border and in Vietnam. They were tested by PCR to detect DNA of bacteria of the order RICKETTSIALES: Three Anaplasma spp. were detected in ticks collected in Thailand, including (i) Anaplasma sp. strain AnDa465, which was considered a genotype of Anaplasma platys (formerly Ehrlichia platys) and which was obtained from Dermacentor auratus ticks collected from dogs; (ii) Anaplasma sp. strain AnAj360, which was obtained from Amblyomma javanense ticks collected on a pangolin; and (iii) Anaplasma sp. strain AnHl446, which was closely related to Anaplasma bovis and which was detected in Haemaphysalis lagrangei ticks collected from a bear. Three Ehrlichia spp. were identified, including (i) Ehrlichia sp. strain EBm52, which was obtained from Boophilus microplus ticks collected from cattle from Thailand; (ii) Ehrlichia sp. strain EHh324, which was closely related to Ehrlichia chaffeensis and which was detected in Haemaphysalis hystricis ticks collected from wild pigs in Vietnam; and (iii) Ehrlichia sp. strain EHh317, which was closely related to Ehrlichia sp. strain EBm52 and which was also detected in H. hystricis ticks collected from wild pigs in Vietnam. Two Rickettsia spp. were detected in Thailand, including (i) Rickettsia sp. strain RDla420, which was detected in Dermacentor auratus ticks collected from a bear, and (ii) Rickettsia sp. strain RDla440, which was identified from two pools of Dermacentor larvae collected from a wild pig nest. Finally, two bacteria named Eubacterium sp. strain Hw124 and Eubacterium sp. strain Hw191 were identified in Haemaphysalis wellingtoni ticks collected from chicken in Thailand; these strains could belong to a new group of bacteria.

  7. Detection of Ehrlichia spp., Anaplasma spp., Rickettsia spp., and Other Eubacteria in Ticks from the Thai-Myanmar Border and Vietnam

    PubMed Central

    Parola, Philippe; Cornet, Jean-Paul; Sanogo, Yibayiri Osée; Miller, R. Scott; Thien, Huynh Van; Gonzalez, Jean-Paul; Raoult, Didier; Telford III, Sam R.; Wongsrichanalai, Chansuda

    2003-01-01

    A total of 650 ticks, including 13 species from five genera, were collected from animals, from people, or by flagging of the vegetation at sites on the Thai-Myanmar border and in Vietnam. They were tested by PCR to detect DNA of bacteria of the order Rickettsiales. Three Anaplasma spp. were detected in ticks collected in Thailand, including (i) Anaplasma sp. strain AnDa465, which was considered a genotype of Anaplasma platys (formerly Ehrlichia platys) and which was obtained from Dermacentor auratus ticks collected from dogs; (ii) Anaplasma sp. strain AnAj360, which was obtained from Amblyomma javanense ticks collected on a pangolin; and (iii) Anaplasma sp. strain AnHl446, which was closely related to Anaplasma bovis and which was detected in Haemaphysalis lagrangei ticks collected from a bear. Three Ehrlichia spp. were identified, including (i) Ehrlichia sp. strain EBm52, which was obtained from Boophilus microplus ticks collected from cattle from Thailand; (ii) Ehrlichia sp. strain EHh324, which was closely related to Ehrlichia chaffeensis and which was detected in Haemaphysalis hystricis ticks collected from wild pigs in Vietnam; and (iii) Ehrlichia sp. strain EHh317, which was closely related to Ehrlichia sp. strain EBm52 and which was also detected in H. hystricis ticks collected from wild pigs in Vietnam. Two Rickettsia spp. were detected in Thailand, including (i) Rickettsia sp. strain RDla420, which was detected in Dermacentor auratus ticks collected from a bear, and (ii) Rickettsia sp. strain RDla440, which was identified from two pools of Dermacentor larvae collected from a wild pig nest. Finally, two bacteria named Eubacterium sp. strain Hw124 and Eubacterium sp. strain Hw191 were identified in Haemaphysalis wellingtoni ticks collected from chicken in Thailand; these strains could belong to a new group of bacteria. PMID:12682151

  8. The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension.

    PubMed

    Lennernäs, Hans; Abrahamsson, Bertil

    2005-03-01

    Bioavailability (BA) and bioequivalence (BE) play a central role in pharmaceutical product development and BE studies are presently being conducted for New Drug Applications (NDAs) of new compounds, in supplementary NDAs for new medical indications and product line extensions, in Abbreviated New Drug Applications (ANDAs) of generic products and in applications for scale-up and post-approval changes. The Biopharmaceutics Classification System (BCS) has been developed to provide a scientific approach for classifying drug compounds based on solubility as related to dose and intestinal permeability in combination with the dissolution properties of the oral immediaterelease (IR) dosage form. The aim of the BCS is to provide a regulatory tool for replacing certain BE studies by accurate in-vitro dissolution tests. The aim of this review is to present the status of the BCS and discuss its future application in pharmaceutical product development. The future application of the BCS is most likely increasingly important when the present framework gains increased recognition, which will probably be the case if the BCS borders for certain class II and III drugs are extended. The future revision of the BCS guidelines by the regulatory agencies in communication with academic and industrial scientists is exciting and will hopefully result in an increased applicability in drug development. Finally, we emphasize the great use of the BCS as a simple tool in early drug development to determine the rate-limiting step in the oral absorption process, which has facilitated the information between different experts involved in the overall drug development process. This increased awareness of a proper biopharmaceutical characterization of new drugs may in the future result in drug molecules with a sufficiently high permeability, solubility and dissolution rate, and that will automatically increase the importance of the BCS as a regulatory tool over time.

  9. Younger people with Type 2 diabetes have poorer self-care practices compared with older people: results from the Australian National Diabetes Audit.

    PubMed

    Nanayakkara, N; Pease, A J; Ranasinha, S; Wischer, N; Andrikopoulos, S; de Courten, B; Zoungas, S

    2018-05-05

    This cross-sectional study compares the self-care practices of younger and older people with Type 2 diabetes. Data were analysed from the Australian National Diabetes Audit (ANDA) including 2552 adults with Type 2 diabetes from Australian Diabetes Centres. Pre-specified demographic and clinical variables were obtained. Self-care variables (physical activity, following dietary recommendations, medication adherence and monitoring blood glucose levels) were compared in people ≤ 64 and > 64 years of age. Mean age (± sd) of participants was 63 ± 13 years overall, 53 ± 9 years for the younger group and 73 ± 6 years for the older group. A greater proportion of younger people had HbA 1c levels > 53 mmol/mol (> 7.0%) (76% vs. 68%), reported difficulty following dietary recommendations (50% vs. 32%) and forgetting medications (37% vs. 22%) compared with older people (all P-values <0.001). A smaller proportion of younger compared with older people reported monitoring their blood glucose levels as often as recommended (60% vs. 70%, P < 0.001). Similar proportions of people aged ≤ 64 and > 64 years required insulin therapy (59% vs. 57%, P = 0.200). Younger age was associated with a twofold increase in the odds of not following the recommended self-care practices after adjustment for gender, smoking, insulin therapy, depression and allied health attendance (all P < 0.001). Despite shorter diabetes duration, younger age was associated with worse glycaemic control and poorer diabetes self-care practices among people with Type 2 diabetes. Targeted strategies are required to optimize diabetes self-care practices and thereby glycaemic control. © 2018 Diabetes UK.

  10. [Evaluation of injuries by means of photographs in a homicide (manslaughter or murder) barred by the statute of limitations].

    PubMed

    Madea, Burkhard

    2009-01-01

    Pursuant to Section 78 German Criminal Code, criminal offences under Section 220a (genocide) and Section 211 (murder) are not subject to a statute of limitations. To the extent that prosecution is subject to a statute of limitations, the period of limitation is thirty years in the case of acts punishable by imprisonment for life. After the expiration of the period of limitation, evidence and investigation records relevant for the offence may no longer be available. Once a homicide is statute-barred, main proceedings may be opened only, if the elements of murder are present. The problems arising from the statute of limitations are discussed on the basis of a case on which the author had to give an export opinion. The homicide was committed in Amsterdam in 1967. In 2004, after the period of limitation had expired in The Netherlands and--as far as manslaughter is concerned, also in the Federal Republic of Germany--a meanwhile 60-year-old man accused himself of having committed the offence (manual strangulation of a tied male). After the expiration of the statute of limitations the results of the police investigations and the autopsy report were no longer available. How the offence might have been committed and whether the elements of murder were present therefore had to be discussed on the basis of still available photographs of the crime scene and the victim. After studying these pieces of evidence, the criminal court decided that the accused had actually committed a voluntary homicide, but that it was no longer ascertainable, if the elements of murder were fulfilled. The issues relevant to legal medicine are presented against the background of the problems associated with the statute of limitations.

  11. Data-Based Mapping of Our Dynamical Magnetosphere (Julius Bartels Medal Lecture)

    NASA Astrophysics Data System (ADS)

    Tsyganenko, Nikolai A.

    2013-04-01

    The geomagnetic field is a principal agent connecting our planet's ionosphere with thehighly variable interplanetary medium, incessantly disturbed by dynamical processesat the Sun. The Earth's magnetosphere serves as a giant storage reservoir of energy pumped in from the solar wind and intermittently spilled into the upperatmosphere during space storms. As the humankindgets more and more dependent on space technologies, it becomes increasingly important to be able to accurately map the distant geomagnetic field and predict its dynamicsusing data of upstream solar wind monitors. Two approaches to the problem have beensuccessfully pursued over last decades. The first one is to treat the solar wind asa flow of magnetized conducting fluid and to numerically solve first-principle equations,governing its interaction with the terrestrial magnetic dipole. Based on pure theory, that approachaddresses the question: "What the magnetosphere would look like and behaveunder assumption thatthe underlying approximations and techniques were universally accurate?" This lecturewill focus on the other, completely different approach, based on direct observations. Its essence is to develop an empirical description of the global geomagnetic field and its response to the solar wind driving by fitting model parameters to large multi-year sets of spacecraft data. Models of that kind seek to answer the question: "What can in situ measurements tell us about the global magnetospheric configuration and its storm-time dynamics, provided our approximations are realistic, flexible, and the data coverage is sufficiently dense and broad?" Five decades of spaceflight produced enormous amount of archived data anda number of empirical models have already been developed on that basis. Recent and ongoing multi-spacecraft missions keep pouring in new data and further expandthe huge and yet largely untapped resource of valuable information. The main goal of the data-based modeling is to extract the largest

  12. How Much We Think of Ourselves and How Little We Think of Others: An Investigation of the Neuronal Signature of Self-Consciousness between Different Personality Traits through an Event-Related Potential Study.

    PubMed

    Hassan, Auwal Bello; Begum, Tahamina; Reza, Mohammed Faruque; Yusoff, Nasir

    2016-11-01

    Previous studies have revealed that self-related tasks (items) receive more attention than non-self-related, and that they elicit event-related potential (ERP) components with larger amplitudes. Since personality has been reported as one of the biological correlates influencing these components, as well as our behavioural differences, it is important to examine how it affects our self-consciousness in relation to tasks of varied relevance and the neurological basis. A total of 33 male and female undergraduate Malaysian medical students of Universiti Sains Malaysia (USM) participated in the study. The participants were divided into two groups, Ambivert ( n = 18) and Extravert ( n = 15) groups, using the USM personality inventory questionnaire. In the ERP experiment, squares containing standard stimuli of any word other than self and non-self-related nouns (e.g., Bola , Gigi , Anak , etc.; in English: Ball, Teeth, Kids, etc., respectively), those containing self-related pronouns ( Saya , Kami or Kita ; in English: I, Us or We, respectively), and non-self-related pronouns ( Dia , Anda or Mereka ; in English: He/She, You or They, respectively), were shown 58%, 21% and 21% of the time, respectively, in a three-stimulus visual oddball paradigm. All words were presented in Bahasa Melayu. The participants were instructed to press 1 for self and 2 for non-self, and ignore standard stimuli. Comparison of both N200 and P300 amplitudes for self-related and non-self-related pronouns in the Extravert group revealed significant differences at seven electrode sites, with self-related having larger amplitude at anterior electrodes and less at posterior. This was not seen in the Ambivert group. The present study suggests that self-relevant pronouns are psychologically more important to extraverts than to ambiverts; hence, they have more self-awareness. This may be due to large amount of dopamine in the brains of extraverts, which is more concentrated in the frontal lobe.

  13. Validity and reliability of the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in individuals with congenital heart disease.

    PubMed

    Voss, Christine; Dean, Paige H; Gardner, Ross F; Duncombe, Stephanie L; Harris, Kevin C

    2017-01-01

    To assess the criterion validity, internal consistency, reliability and cut-point for the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in children and adolescents with congenital heart disease-a special population at high cardiovascular risk in whom physical activity has not been extensively evaluated. We included 84 participants (13.6±2.9 yrs, 50% female) with simple (37%), moderate (31%), or severe congenital heart disease (27%), as well as cardiac transplant recipients (6%), from BC Children's Hospital, Canada. They completed the PAQ-C (≤11yrs, n = 28) or-A (≥12yrs, n = 56), and also wore a triaxial accelerometer (GT3X+ or GT9X) over the right hip for 7 days (n = 59 met valid wear time criteria). Median daily moderate-to-vigorous physical activity was 46.9 minutes per day (IQR 31.6-61.8) and 25% met physical activity guidelines defined as ≥60 minutes of moderate-to-vigorous physical activity per day. Median PAQ-score was 2.6 (IQR 1.9-3.0). PAQ-Scores were significantly related to accelerometry-derived metrics of physical activity (rho = 0.44-0.55, all p<0.01) and sedentary behaviour (rho = -0.53, p<0.001). Internal consistency was high (α = 0.837), as was reliability (stability) of PAQ-Scores over a 4-months period (ICC = 0.73, 95%CI 0.55-0.84; p<0.001). We identified that a PAQ-Score cut-point of 2.87 discriminates between those meeting physical guidelines and those that do not in the combined PAQ-C and-A samples (area under the curve = 0.80 (95%CI 0.67-0.92). Validity and reliability of the PAQ in children and adolescents with CHD was comparable to or stronger than previous studies in healthy children. Therefore, the PAQ may be used to estimate general levels of physical activity in children and adolescents with CHD.

  14. How Much We Think of Ourselves and How Little We Think of Others: An Investigation of the Neuronal Signature of Self-Consciousness between Different Personality Traits through an Event-Related Potential Study

    PubMed Central

    Hassan, Auwal Bello; Begum, Tahamina; Reza, Mohammed Faruque; Yusoff, Nasir

    2016-01-01

    Background Previous studies have revealed that self-related tasks (items) receive more attention than non-self-related, and that they elicit event-related potential (ERP) components with larger amplitudes. Since personality has been reported as one of the biological correlates influencing these components, as well as our behavioural differences, it is important to examine how it affects our self-consciousness in relation to tasks of varied relevance and the neurological basis. Methods A total of 33 male and female undergraduate Malaysian medical students of Universiti Sains Malaysia (USM) participated in the study. The participants were divided into two groups, Ambivert (n = 18) and Extravert (n = 15) groups, using the USM personality inventory questionnaire. In the ERP experiment, squares containing standard stimuli of any word other than self and non-self-related nouns (e.g., Bola, Gigi, Anak, etc.; in English: Ball, Teeth, Kids, etc., respectively), those containing self-related pronouns (Saya, Kami or Kita; in English: I, Us or We, respectively), and non-self-related pronouns (Dia, Anda or Mereka; in English: He/She, You or They, respectively), were shown 58%, 21% and 21% of the time, respectively, in a three-stimulus visual oddball paradigm. All words were presented in Bahasa Melayu. The participants were instructed to press 1 for self and 2 for non-self, and ignore standard stimuli. Results Comparison of both N200 and P300 amplitudes for self-related and non-self-related pronouns in the Extravert group revealed significant differences at seven electrode sites, with self-related having larger amplitude at anterior electrodes and less at posterior. This was not seen in the Ambivert group. Conclusion The present study suggests that self-relevant pronouns are psychologically more important to extraverts than to ambiverts; hence, they have more self-awareness. This may be due to large amount of dopamine in the brains of extraverts, which is more concentrated in

  15. Investigating the limitations of tree species classification using the Combined Cluster and Discriminant Analysis method for low density ALS data from a dense forest region in Aggtelek (Hungary)

    NASA Astrophysics Data System (ADS)

    Koma, Zsófia; Deák, Márton; Kovács, József; Székely, Balázs; Kelemen, Kristóf; Standovár, Tibor

    2016-04-01

    ), data evaluation: 'Multipurpose assessment serving forest biodiversity conservation in the Carpathian region of Hungary', Swiss-Hungarian Cooperation Programme (SH/4/13 Project). BS contributed as an Alexander von Humboldt Research Fellow. J. Kovács, S. Kovács, N. Magyar, P. Tanos, I. G. Hatvani, and A. Anda (2014), Classification into homogeneous groups using combined cluster and discriminant analysis, Environmental Modelling & Software, 57, 52-59.

  16. Commercial Serological Tests for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis: An Updated Systematic Review and Meta-Analysis

    PubMed Central

    Steingart, Karen R.; Flores, Laura L.; Dendukuri, Nandini; Schiller, Ian; Laal, Suman; Ramsay, Andrew; Hopewell, Philip C.; Pai, Madhukar

    2011-01-01

    Background Serological (antibody detection) tests for tuberculosis (TB) are widely used in developing countries. As part of a World Health Organization policy process, we performed an updated systematic review to assess the diagnostic accuracy of commercial serological tests for pulmonary and extrapulmonary TB with a focus on the relevance of these tests in low- and middle-income countries. Methods and Findings We used methods recommended by the Cochrane Collaboration and GRADE approach for rating quality of evidence. In a previous review, we searched multiple databases for papers published from 1 January 1990 to 30 May 2006, and in this update, we add additional papers published from that period until 29 June 2010. We prespecified subgroups to address heterogeneity and summarized test performance using bivariate random effects meta-analysis. For pulmonary TB, we included 67 studies (48% from low- and middle-income countries) with 5,147 participants. For all tests, estimates were variable for sensitivity (0% to 100%) and specificity (31% to 100%). For anda-TB IgG, the only test with enough studies for meta-analysis, pooled sensitivity was 76% (95% CI 63%–87%) in smear-positive (seven studies) and 59% (95% CI 10%–96%) in smear-negative (four studies) patients; pooled specificities were 92% (95% CI 74%–98%) and 91% (95% CI 79%–96%), respectively. Compared with ELISA (pooled sensitivity 60% [95% CI 6%–65%]; pooled specificity 98% [95% CI 96%–99%]), immunochromatographic tests yielded lower pooled sensitivity (53%, 95% CI 42%–64%) and comparable pooled specificity (98%, 95% CI 94%–99%). For extrapulmonary TB, we included 25 studies (40% from low- and middle-income countries) with 1,809 participants. For all tests, estimates were variable for sensitivity (0% to 100%) and specificity (59% to 100%). Overall, quality of evidence was graded very low for studies of pulmonary and extrapulmonary TB. Conclusions Despite expansion of the literature since 2006

  17. Rarefaction-driven Rayleigh–Taylor instability. Part 2. Experiments and simulations in the nonlinear regime

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morgan, R. V.; Cabot, W. H.; Greenough, J. A.

    Experiments and large eddy simulation (LES) were performed to study the development of the Rayleigh–Taylor instability into the saturated, nonlinear regime, produced between two gases accelerated by a rarefaction wave. Single-mode two-dimensional, and single-mode three-dimensional initial perturbations were introduced on the diffuse interface between the two gases prior to acceleration. The rarefaction wave imparts a non-constant acceleration, and a time decreasing Atwood number,more » $$A=(\\unicode[STIX]{x1D70C}_{2}-\\unicode[STIX]{x1D70C}_{1})/(\\unicode[STIX]{x1D70C}_{2}+\\unicode[STIX]{x1D70C}_{1})$$, where$$\\unicode[STIX]{x1D70C}_{2}$$and$$\\unicode[STIX]{x1D70C}_{1}$$are the densities of the heavy and light gas, respectively. Experiments and simulations are presented for initial Atwood numbers of$A=0.49$$,$$A=0.63$$,$$A=0.82$$and$$A=0.94$$. Nominally two-dimensional (2-D) experiments (initiated with nearly 2-D perturbations) and 2-D simulations are observed to approach an intermediate-time velocity plateau that is in disagreement with the late-time velocity obtained from the incompressible model of Goncharov (Phys. Rev. Lett., vol. 88, 2002, 134502). Reacceleration from an intermediate velocity is observed for 2-D bubbles in large wavenumber,$$k=2\\unicode[STIX]{x03C0}/\\unicode[STIX]{x1D706}=0.247~\\text{mm}^{-1}$$, experiments and simulations, where$$\\unicode[STIX]{x1D706}$is the wavelength of the initial perturbation. At moderate Atwood numbers, the bubble and spike velocities approach larger values than those predicted by Goncharov’s model. These late-time velocity trends are predicted well by numerical simulations using the LLNL Miranda code, and by the 2009 model of Mikaelian (Phys. Fluids., vol. 21, 2009, 024103) that extends Layzer type models to variable acceleration and density. Large Atwood number experiments show a delayed roll up, and exhibit a free-fall like behaviour. Finally, experiments initiated with three

  18. Serological testing versus other strategies for diagnosis of active tuberculosis in India: a cost-effectiveness analysis.

    PubMed

    Dowdy, David W; Steingart, Karen R; Pai, Madhukar

    2011-08-01

    Undiagnosed and misdiagnosed tuberculosis (TB) drives the epidemic in India. Serological (antibody detection) TB tests are not recommended by any agency, but widely used in many countries, including the Indian private sector. The cost and impact of using serology compared with other diagnostic techniques is unknown. Taking a patient cohort conservatively equal to the annual number of serological tests done in India (1.5 million adults suspected of having active TB), we used decision analysis to estimate costs and effectiveness of sputum smear microscopy (US$3.62 for two smears), microscopy plus automated liquid culture (mycobacterium growth indicator tube [MGIT], US$20/test), and serological testing (anda-tb ELISA, US$20/test). Data on test accuracy and costs were obtained from published literature. We adopted the perspective of the Indian TB control sector and an analysis frame of 1 year. Our primary outcome was the incremental cost per disability-adjusted life year (DALY) averted. We performed one-way sensitivity analysis on all model parameters, with multiway sensitivity analysis on variables to which the model was most sensitive. If used instead of sputum microscopy, serology generated an estimated 14,000 more TB diagnoses, but also 121,000 more false-positive diagnoses, 102,000 fewer DALYs averted, and 32,000 more secondary TB cases than microscopy, at approximately four times the incremental cost (US$47.5 million versus US$11.9 million). When added to high-quality sputum smears, MGIT culture was estimated to avert 130,000 incremental DALYs at an incremental cost of US$213 per DALY averted. Serology was dominated by (i.e., more costly and less effective than) MGIT culture and remained less economically favorable than sputum smear or TB culture in one-way and multiway sensitivity analyses. In India, sputum smear microscopy remains the most cost-effective diagnostic test available for active TB; efforts to increase access to quality-assured microscopy should

  19. Rarefaction-driven Rayleigh–Taylor instability. Part 2. Experiments and simulations in the nonlinear regime

    DOE PAGES

    Morgan, R. V.; Cabot, W. H.; Greenough, J. A.; ...

    2018-01-12

    Experiments and large eddy simulation (LES) were performed to study the development of the Rayleigh–Taylor instability into the saturated, nonlinear regime, produced between two gases accelerated by a rarefaction wave. Single-mode two-dimensional, and single-mode three-dimensional initial perturbations were introduced on the diffuse interface between the two gases prior to acceleration. The rarefaction wave imparts a non-constant acceleration, and a time decreasing Atwood number,more » $$A=(\\unicode[STIX]{x1D70C}_{2}-\\unicode[STIX]{x1D70C}_{1})/(\\unicode[STIX]{x1D70C}_{2}+\\unicode[STIX]{x1D70C}_{1})$$, where$$\\unicode[STIX]{x1D70C}_{2}$$and$$\\unicode[STIX]{x1D70C}_{1}$$are the densities of the heavy and light gas, respectively. Experiments and simulations are presented for initial Atwood numbers of$A=0.49$$,$$A=0.63$$,$$A=0.82$$and$$A=0.94$$. Nominally two-dimensional (2-D) experiments (initiated with nearly 2-D perturbations) and 2-D simulations are observed to approach an intermediate-time velocity plateau that is in disagreement with the late-time velocity obtained from the incompressible model of Goncharov (Phys. Rev. Lett., vol. 88, 2002, 134502). Reacceleration from an intermediate velocity is observed for 2-D bubbles in large wavenumber,$$k=2\\unicode[STIX]{x03C0}/\\unicode[STIX]{x1D706}=0.247~\\text{mm}^{-1}$$, experiments and simulations, where$$\\unicode[STIX]{x1D706}$is the wavelength of the initial perturbation. At moderate Atwood numbers, the bubble and spike velocities approach larger values than those predicted by Goncharov’s model. These late-time velocity trends are predicted well by numerical simulations using the LLNL Miranda code, and by the 2009 model of Mikaelian (Phys. Fluids., vol. 21, 2009, 024103) that extends Layzer type models to variable acceleration and density. Large Atwood number experiments show a delayed roll up, and exhibit a free-fall like behaviour. Finally, experiments initiated with three

  20. Molecular modeling of the neurophysin I/oxytocin complex

    NASA Astrophysics Data System (ADS)

    Kazmierkiewicz, R.; Czaplewski, C.; Lammek, B.; Ciarkowski, J.

    1997-01-01

    Neurophysins I and II (NPI and NPII) act in the neurosecretory granules as carrier proteinsfor the neurophyseal hormones oxytocin (OT) and vasopressin (VP), respectively. The NPI/OTfunctional unit, believed to be an (NPI/OT)2 heterotetramer, was modeled using low-resolution structure information, viz. the Cα carbon atom coordinates of the homologousNPII/dipeptide complex (file 1BN2 in the Brookhaven Protein Databank) as a template. Itsall-atom representation was obtained using standard modeling tools available within theINSIGHT/Biopolymer modules supplied by Biosym Technologies Inc. A conformation of theNPI-bound OT, similar to that recently proposed in a transfer NOE experiment, was dockedinto the ligand-binding site by a superposition of its Cys1-Tyr2 fragment onto the equivalentportion of the dipeptide in the template. The starting complex for the initial refinements wasprepared by two alternative strategies, termed Model I and Model II, each ending with a˜100 ps molecular dynamics (MD) simulation in water using the AMBER 4.1 force field. The freehomodimer NPI2 was obtained by removal of the two OT subunits from their sites, followedby a similar structure refinement. The use of Model I, consisting of a constrained simulatedannealing, resulted in a structure remarkably similar to both the NPII/dipeptide complex anda recently published solid-state structure of the NPII/OT complex. Thus, Model I isrecommended as the method of choice for the preparation of the starting all-atom data forMD. The MD simulations indicate that, both in the homodimer and in the heterotetramer, the310-helices demonstrate an increased mobility relative to the remaining body of the protein.Also, the C-terminal domains in the NPI2 homodimer are more mobile than the N-terminalones. Finally, a distinct intermonomer interaction is identified, concentrated around its mostprominent, although not unique, contribution provided by an H-bond from Ser25Oγ in one NPI unit to Glu81 Oɛ in the other

  1. SU-D-213AB-05: Commissioning a CT Compatible LDR T&O Applicator Using Analytical Calculation with ID and 3D Dosimetry.

    PubMed

    Adamson, J; Newton, J; Steffey, B; Cai, J; Adamovics, J; Oldham, M; Chino, J; Craciunescu, O

    2012-06-01

    To determine the characteristics of a new commercially available CT-compatible LDR Tandem and Ovoid (T&O) applicator using 3D dosimetry. We characterized source attenuation through the asymmetric gold shielding in the buckets by measuring dose with diode and 3D dosimetry and compared to an analytical line integral calculation. For 3D dosimetry, a cylindrical PRESAGE dosimeter (9.5cm diameter, 9.2cm height) with a central 6mm channel bored for source placement was scanned with the Duke Large field of view Optical CT-Scanner (DLOS) before and after delivering a nominal 7.7Gy at a distance of 1 cm using a Cs-137 source loaded in the bucket. The optical CT scan time lasted approximately 15 minutes during which 720 projections were acquired at 0.5° increments, anda 3D dose distribution was reconstructed with a 0.5mm 3 isotropic voxel size. The 3D dose distribution was applied to a CT-based T&O implant to determine effect of ovoid shielding on the dose delivered to ICRU 38 Point A as well as D2cc of the bladder, rectum, bowel, and sigmoid. Dose transmission through the gold shielding at a radial distance of 1-3cm from midplane of the source was 86.6%, 86.1, and 87.0% for analytical calculation, diode, and 3D dosimetry, respectively. For the gold shielding of the bucket, dose transmission calculated using the 3D dosimetrymeasurement was found to be lowest at oblique angles from the bucket witha minimum of ∼51%. For the patient case, attenuation from the buckets leadto a decrease in average Point A dose of ∼4% and decrease in D2cc to bladder, rectum, sigmoid, and bowel of 2%, 15%, 2%, and 7%, respectively. The measured 3D dose distribution provided unique insight to the dosimetry and shielding characteristics of the investigated applicator, the technique for which can be applied to commissioning of other brachytherapy applicators. John Adamovics is the owner of Heuris Pharma LLC. Partially supported by NIH Grant R01 CA100835-01. © 2012 American Association of

  2. [3-dimensional computer animation--a new medium for supporting patient education before surgery. Acceptance and assessment of patients based on a prospective randomized study--picture versus text].

    PubMed

    Hermann, M

    2002-05-01

    of new media such as the world wide web, CD, DVD, and digital TV are readily available and--as shown here--suitable for effective visual explanation. Most patients are familiar with acquiring new information by one of these means. An appropriately designed 3D repre-sentation is met with a high level of acceptance, as the present study clearly shows. Modern patient-based information systems are necessary. They can no longer be the sole responsibility of the medical profession, but must be on the agenda of hospital managements and of medical care systems as well.

  3. Surgical outcome of traumatic aortic disruption of the thoracic aorta in Songklanagarind Hospital.

    PubMed

    Chittithavorn, Voravit; Vasinanukorn, Prasert; Rergkliang, Chareonkiat; Chetpaophan, Apirak

    2004-09-01

    This retrospective study collected data from 11 patients who underwent TDTA' repair from February 1987 to June 2003, 10 patients were men (90.9%) and 1 was a woman (9.09%) with a mean age of 32 years. All patients had a blunt injury from a violent motor vehicle accident. None of them required thoracotomy at the emergency room. Standard chest x-ray was done in every patient and the widening of the upper mediastinum was mainly found in 10 patients (90.9%), hemothorax in 8 patients, blurred aortic knob in 7 patients, lower left main bronchus in 3 patients, pleural apical cap in 2 patients and pneumothorax in 1 patient, 8 patients were investigated by CT scan and presented a positive study. 3 patients (27.27%) were diagnosed by both aortogram and CT scan anda pseudo-false aneurysm was found Multi organ system injury was mainly found in 10 patients (90.91%). 7 patients (63.64%) had hypovolumic shock on admission, 3 patients died postoperation and 2 of them had experience of postoperative paraplegia. Clamp and sew technique was used in 6 patients (54.54%). The duration of aortic cross clamp time ranged from 19-67 minutes (mean time = 39.30 min.) Pneumonia was the significant postoperative complication found in 3 patients, including acute renal failure, ARDS (all died) and paraplegia in 2 patients. The duration of the aortic cross clamp time that was used in the patients who presented with paraplegia was more than 40 minutes. 1 patient had delayed the aortic repair for 3 weeks resulting from severe brain contusion. 5 patients (45.45%) died in hospital. 1 patient died in the operating theatre, 4 of them (36.36%) died during postoperatively within 24 hours. The mainly cause of death which occurred in every patient was intraoperative cardiac arrest, the others were postoperative bleeding, ARDS and arrhythmias. The mean of length of stay in the intensive care unit was 6.94 days. The period of hospitalization ranged from 11 to 180 days (mean = 62.83 days). The small sample

  4. Commercial Serological Antibody Detection Tests for the Diagnosis of Pulmonary Tuberculosis: A Systematic Review

    PubMed Central

    Steingart, Karen R; Henry, Megan; Laal, Suman; Hopewell, Philip C; Ramsay, Andrew; Menzies, Dick; Cunningham, Jane; Weldingh, Karin; Pai, Madhukar

    2007-01-01

    Background The global tuberculosis epidemic results in nearly 2 million deaths and 9 million new cases of the disease a year. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using conventional light microscopy. Microscopy has high specificity in tuberculosis-endemic countries, but modest sensitivity which varies among laboratories (range 20% to 80%). Moreover, the sensitivity is poor for paucibacillary disease (e.g., pediatric and HIV-associated tuberculosis). Thus, the development of rapid and accurate new diagnostic tools is imperative. Immune-based tests are potentially suitable for use in low-income countries as some test formats can be performed at the point of care without laboratory equipment. Currently, dozens of distinct commercial antibody detection tests are sold in developing countries. The question is “do they work?” Methods and Findings We conducted a systematic review to assess the accuracy of commercial antibody detection tests for the diagnosis of pulmonary tuberculosis. Studies from all countries using culture and/or microscopy smear for confirmation of pulmonary tuberculosis were eligible. Studies with fewer than 50 participants (25 patients and 25 control participants) were excluded. In a comprehensive search, we identified 68 studies. The results demonstrate that (1) overall, commercial tests vary widely in performance; (2) sensitivity is higher in smear-positive than smear-negative samples; (3) in studies of smear-positive patients, Anda-TB IgG by enzyme-linked immunosorbent assay shows limited sensitivity (range 63% to 85%) and inconsistent specificity (range 73% to 100%); (4) specificity is higher in healthy volunteers than in patients in whom tuberculosis disease is initially suspected and subsequently ruled out; and (5) there are insufficient data to determine the accuracy of most commercial tests

  5. Social Disparities in Drinking Water Quality in California's San Joaquin Valley

    NASA Astrophysics Data System (ADS)

    Ray, I.; Balazs, C.; Hubbard, A.; Morello-Frosch, R.

    2011-12-01

    Social Disparities in Drinking Water Quality in California's San Joaquin Valley Carolina Balazs, Rachel Morello-Frosch, Alan Hubbard and Isha Ray Little attention has been given to research on social disparities and environmental justice in access to safe drinking water in the USA. We examine the relationship between nitrate and arsenic concentrations in community water systems (CWS) and the ethnic and socioeconomic characteristics of their customers. We hypothesized that systems in the San Joaquin Valley that serve a higher proportion of minority (especially Latino) residents, and/or lower socioeconomic status (proxied by rates of home ownership) residents, have higher nitrate levels and higher arsenic levels. We used water quality monitoring datasets (1999-2001) to estimate nitrate as well as arsenic levels in CWS, and source location and Census block group data to estimate customer demographics. We found that percent Latino was associated with a .04 mg NO3/L increase in a CWS' estimated nitrate ion concentration (95% CI, -.08, .16) and rate of home ownership was associated with a .16 mg NO3/L decrease (95% CI, -.32, .002). We also found that each percent increase in home ownership rate was associated with a .30 ug As/L decrease in arsenic concentrations (p<.05), but our data showed no significant correlation between arsenic concentration and percent Latino. These results show that exposure disparities and compliance burdens in accordance with EPA standards fell most heavily on socio-economically disadvantaged communities. Selected References Cory DC, Rahman T. 2009. Environmental justice and enforcement of the safe drinking water act: The arizona arsenic experience. Ecological Economics 68: 1825-1837. Krieger N, Williams DR, Moss NE. 1997. Measuring social class in us public health research: Concepts, methodologies, and guidelines. Annual Review of Public Health 18(341-378). Moore E, Matalon E, Balazs C, Clary J, Firestone L, De Anda S, Guzman, M. 2011. The

  6. A GIS modeling method applied to predicting forest songbird habitat

    USGS Publications Warehouse

    Dettmers, Randy; Bart, Jonathan

    1999-01-01

    We have developed an approach for using a??presencea?? data to construct habitat models. Presence data are those that indicate locations where the target organism is observed to occur, but that cannot be used to define locations where the organism does not occur. Surveys of highly mobile vertebrates often yield these kinds of data. Models developed through our approach yield predictions of the amount and the spatial distribution of good-quality habitat for the target species. This approach was developed primarily for use in a GIS context; thus, the models are spatially explicit and have the potential to be applied over large areas. Our method consists of two primary steps. In the first step, we identify an optimal range of values for each habitat variable to be used as a predictor in the model. To find these ranges, we employ the concept of maximizing the difference between cumulative distribution functions of (1) the values of a habitat variable at the observed presence locations of the target organism, and (2) the values of that habitat variable for all locations across a study area. In the second step, multivariate models of good habitat are constructed by combining these ranges of values, using the Boolean operators a??anda?? and a??or.a?? We use an approach similar to forward stepwise regression to select the best overall model. We demonstrate the use of this method by developing species-specific habitat models for nine forest-breeding songbirds (e.g., Cerulean Warbler, Scarlet Tanager, Wood Thrush) studied in southern Ohio. These models are based on speciesa?? microhabitat preferences for moisture and vegetation characteristics that can be predicted primarily through the use of abiotic variables. We use slope, land surface morphology, land surface curvature, water flow accumulation downhill, and an integrated moisture index, in conjunction with a land-cover classification that identifies forest/nonforest, to develop these models. The performance of these

  7. textbf{Historical Usage Inventories of DDT in China}

    NASA Astrophysics Data System (ADS)

    Qiang, Wang; Lijuan, Zhao; Jianxin, Hu

    2010-05-01

    Dichlorodiphenyltrichloroethane (DDT) is one of organochlorine pesticides and listed as one of the persistent organic pollutants to be reduced and finally eliminated in the Stockholm Convention on Persistent Organic Pollutants, because of its great persistence, toxics, bio-accumulation and potential for long-range transport. It is critical to create national DDT usage/emission inventories for China to carry out source-receptor relation analysis, risk assessment, and other research related to DDT in this country. Chinese inventories of DDT to the year1983 have been published; however, DDT is still being used indirectly in the dicifol producing and being applied for malaria control in case. Therefore it is needed to supplement and update the inventories. DDT production in China can be divided into three phases. Prior to 1965 is the first stage with an annual output of no more than 10,000 tons; 1966-1983 is the second phase. At this stage DDT was produced with an average annual production of 15,500 tons. After 1984 is the third production phase, of which the average annual DDT production was 6,465 tons. Before 1983, DDT was mainly used for agriculture, forestry and pesticides.China used a total of 270,000 tons of DDT during 1951 - 1983. According to China's cropland area, Li Yi-fan create China's DDT usage inventory of 1951-1983. In 1983 the State Council decided to ban DDT producing and DDT is no longer used in agriculture any more, but it is still being used in the producing of dicofol, malaria prevention and treatment anda small amount for export. To this end, this paper calculated theusage inventory of China's DDT from 1984 to 2003. Using sown areas of cotton, apple, citrus, tea and vegetable as surrogate data, usage of dicifolwas calculated, then the usage inventory of DDT resulting from dicofol use and DDT applied for malaria control with prefecture resolution was created. From 1984 to 2003, China used 15,312 tons of DDT, including 12,912 tons of DDT resulting

  8. [Results of Booster Vaccination in Children with Primary Vaccine Failure after Initial Varicella Vaccination].

    PubMed

    Ozakiv, Takao; Nishimura, Naoko; Gotoh, Kensei; Funahashi, Keiji; Yoshii, Hironori; Okuno, Yoshinobu

    2016-05-01

    a significantly higher, antibody response than that after the initial vaccination (p < 0.01). Side reactions were generally minor, including fever (≥ 37.5 degrees C), rash at the injection site, and rash at other sites. There were no significant differences in the incidences of side reactions between the initial and booster vaccinations. A total of 185 participants responded to the questionnaire (response rate : 68%), and the period between receiving the initial vaccination and their response to the questionnaire ranged from 1.0 to 7.5 years (median : 4.0 years). The prevalence of breakthrough varicella after the initial vaccination was 17% among seroconverters who did not receive booster vaccination and 14% among non-seroconverters who received booster vaccination, showing no significant difference between the two groups. In conclusion, there are no safety issues regarding the administration of a booster vaccination to children with PVF after an initial varicella vaccination, and,a good antibody response can be expected.

  9. Committees and organizers

    NASA Astrophysics Data System (ADS)

    2011-07-01

    Chairman:Jozef Spałek (Kraków) Program Committee:Stephen Blundell (Oxford), J Michael D Coey (Dublin), Dominique Givord (Grenoble), Dariusz Kaczorowski (Wrocław), Roman Micnas (Poznań), Marek Przybylski (Halle), Ludiwig Schultz (Dresden), Vladimir Sechovsky (Prague), Jozef Spałek (Kraków), Henryk Szymczak (Warszawa), Manuel Vázquez (Madrid) Publication Committee:Dariusz Kaczorowski, Robert Podsiadły, Jozef Spałek, Henryk Szymczak, Andrzej Szytuła Local committee:Maria Bałanda, Anna Majcher, Robert Podsiadły, Michał Rams, Andrzej Ślebarski, Krzysztof Tomala Editors of the Proceedings:Jozef Spałek, Krzysztof Tomala, Danuta Goc-Jagło, Robert Podsiadły, Michał Rams, Anna Majcher Plenary, semi-plenary and tutorial speakers:Ernst Bauer (Wien)Stephen Blundell (Oxford)J Michael D Coey (Dublin)Russell P Cowburn (London)Burkard Hillebrands (Kaiserslautern)Claudine Lacroix (Grenoble)Lluís Mañosa (Barcelona)María del Carmen Muñoz (Madrid)Bernard Raveau (Caen)Pedro Schlottmann (Tallahassee)Frank Steglich (Dresden)Oliver Waldmann (Freiburg) Invited speakers within symposia: R Ahuja (Uppsala)A Kirilyuk (Nijmegen) M Albrecht (Vienna)L Theil Kuhn (Roskilde) K Bärner (Göttingen)J Liu (Dresden) U Bovensiepen (Duisburg)G Lorusso (Modena) V Buchelnikov (Chelyabinsk)M M Maska (Katowice) B Chevalier (Bordeaux)Y Mukovskii (Moscow) O Chubykalo-Fesenko (Madrid)M Pannetier-Lecoeur (Saclay) A V Chumak (Kaiserslautern)G Papavassiliou (Athens) J M D Coey (Dublin)K R Pirota (Campinas) B Dabrowski (DeKalb)P Przyslupski (Warszawa) S Das (Aveiro)M Reiffers (Košice) A del Moral (Zaragoza)K Sandeman (London) V E Demidov (Muenster)D Sander (Halle) B Djafari-Rouhani (Lille)M Sawicki (Sendai/Warsaw) H A Dürr (Menlo Park)J Schaefer (Würzburg) J Fassbender (Dresden)H Schmidt (Wetzikon) J Fontcuberta (Barcelona)J Spałek (Kraków) V Garcia (Orsay)L Straka (Helsinki) J N Gonçalves (Aveiro)A Szewczyk (Warszawa) M E Gruner (Duisburg)Y Taguchi (Wako) G Gubbiotti (Perugia)A Thiaville

  10. The influence of oxazaphosphorines alkylating agents on autonomic nervous system activity in rat experimental cystitis model.

    PubMed

    Dobrek, Łukasz; Baranowska, Agnieszka; Thor, Piotr J

    2013-01-01

    HF) values, the VLF percentage change seems to be of special meaning. IF produced smaller autonomic disturbances, and gentler bladders histological abnormalities comparing to CP. However, similar to CP, VLF [%] relative augmentation together with LF [%] and HF [%] drop accompanied the global ANS activity decrease. Additionally, in the case of IF treatment, a slight trend of nLF increase with nHF decrease was noted, suggesting the possible functional rearrangement between sympathetic (nLF) and parasympathetic (nHF) tension. It seems possible that the vagal withdrawal and--as a consequence--sympathetic overactivity, reflected by VLF [%] enlargement and HF and LF [%] diminishing (as well as LF and HF values decrease), may be an evidence of impaired anti-inflammatory cholinergic pathway, aggravating bladder inflammatory lesions. To sum up, our study showed ANS impairment in both CP- and IF-evoked experimental HC that was reflected in HRV recordings. HRV study, thus, may be considered to be a diagnostic tool for CP/IF treated patients, estimating autonomic abnormalities, associated with the HC development risk and its clinical course.

  11. Abnormal Eu behavior at formation of H2O- and Cl-bearing fluids during degassing of granite magmas

    NASA Astrophysics Data System (ADS)

    Lukanin, Oleg

    2010-05-01

    One of the important features of REE behavior in the process of decompression degassing of granite melts is the presence of europium anomalies in REE spectrum of forming fluid phase. Negative Eu anomaly in REE spectrum of fluids enriched by chlorine that were formed under high pressures at early stages of degassing relative to REE spectrum of granite melts may take place. Negative Eu anomaly in fluid is replaced by positive one with pressure decrease and decline of Cl concentration in fluid [1, 2]. Observable unique features of europium redistribution between fluid and melt find an explanation in such a fact that Eu in contrast to the other REE under oxidation-reduction conditions, being typical for magmatic process, is present in acidic silica-alumina melts in two valency forms Eu3+ and Eu2+ whereas the dominant form for the other REE in such a melts is (REE)3+ [3, 4]. From the analysis of melt-fluid exchange reactions with participation of two valency forms of europium Eu3+ and Eu2+ follows that the total distribution coefficient of Eu between fluid and melt D(Eu)f-m is equal as a first approximation to [5, 6]: D(Eu)f-m = a1α [C(Cl)f]3 + a2 (1 - α)[C(Cl)f]2, where C(Cl)f - the concentration of Cl in fluid, α = Eu3+/(Eu3+ + Eu2+), i.e. fraction of Eu3+ from the general amount of europium in the melt, and, a1anda2- constants that can be approximately estimated from empirical data upon Eu fluid/melt distribution. The equation given allows to estimate the influence of oxidizing condition of europium on sign and size of Eu anomaly, which is expressed by Eu/Eu# ratio, where Eu is real concentration of europium in fluid being in equilibrium with melt with constant Eu3+/(Eu3+ + Eu2+) ratio, and Eu# is possible "virtual" concentration of europium that could be in the same fluid provided that all europium as other REE as well were exclusively present in trivalent form. The sign and size of Eu anomaly in fluid depends upon Cl concentration in fluid and Eu3+/Eu2+ ratio in

  12. More Planets in the Hyades Cluster

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2017-12-01

    through the K2 light curves of young stars as part of the ZEIT (Zodiacal Exoplanets in Time) Survey. Using these data, they identified the presence of three planets in the EPIC 247589423 system:a roughly Earth-sized planet ( 1.0 Earth radii) with a period of 8.0 days,the mini-Neptune identified in the other study, with a size of 2.9 Earth radii and period of 17 days, anda super-Earth, with a size of 1.5 Earth radii and period of 26 days.Light curve of EPIC 247589423 from K2, with the lower panels showing the transits of the three discovered planets. [Mann et al. 2018]The smallest planet is among the youngest Earth-sized planets ever discovered, allowing us a rare glimpse into the history and evolution of planets similar to our own.But these planetary discoveries are additionally exciting because theyre orbiting a bright star thats relatively quiet for its age making the system an excellent target for dedicated radial-velocity observations to determine the planet masses.Since most young star clusters are much further away, they lie out of range of radial-velocity follow-up, rendering EPIC 247589423 a unique opportunity to explore the properties of young planets in detail. With more discoveries like these from Keplers data, we can hope to soon learn more about planets in all their stages of evolution.CitationAndrew W. Mann et al 2018 AJ 155 4. doi:10.3847/1538-3881/aa9791

  13. Effects of human visitation on calf growth and performance of calves fed different milk replacer feeding levels.

    PubMed

    Guindon, N E; Antaya, N T; Cabral, R G; Whitehouse, N L; Earleywine, T J; Erickson, P S

    2015-12-01

    Twenty-eight newborn Holstein heifer calves from the university herd and 8 newborn Holstein heifer calves from a commercial herd were blocked by birth and herd into 1 of 4 treatments: conventional [20% crude protein (CP), 20% fat] milk replacer (MR; treatment C) with (1) or without (0) human visitation, or a higher plane of MR nutrition (28% CP, 20% fat) regimen (treatment A) with (1) or (0) without human visitation. Calves on C MR treatments received 454g of MR from d 2 to 41. Calves on A MR received 916g of MR from d 2 to 8 and 1134g of MR from d 9 to 41. Visitation with calves occurred at 1030 and 1430h daily from d 1 to 56 and comprised verbal stimulation and stirring of starter grain. An opaque curtain divided the calf nursery, with calves in the front half assigned to visitation treatments and those in the rear half not assigned to visitation treatments. Calves were fed their MR treatment until d 43 (preweaning), after which all calves received half of their allotment of MR until d 49 (weaning). Calves were tracked for the next week until d 56 (postweaning). Starter grain and MR intakes were measured daily along with weekly body weight and skeletal measurements. One half of the calves on each treatment had blood samples taken via jugular venipuncture on d 41 (preweaning), 43, 45, 47, 49, and 51 (postweaning) to evaluate blood glucose, urea, nonesterified fatty acids, and cortisol concentrations. During the preweaning and weaning phases, calves on A0 and A1 treatments consumed more MR, less starter, and weighed more than the C0 and C1 calves. Calves on A0 and A1 had greater average daily gain (ADG), hip and withers gain, were taller at the hip, and had larger girths during the preweaning phase. Overall, body weight, withers and hip heights, and heart girths were greater in A0 andA1 calves during the weaning week. Efficiency of utilization of estimated metabolizable energy (ME) intake (ADG/ME) were similar. Glucose and nonesterified fatty acids concentrations

  14. List of Participants

    NASA Astrophysics Data System (ADS)

    2011-08-01

    Abigail Alvarez OlarteCINVESTAV Alba Leticia Carrillo MonteverdeDCI-UG Alberto CarramiñanaINAOE Aldo MorselliFERMI Alejandro CastillaDCI-UG Alejandro IbarraTechnical University of Munich Alma D Rojas PachecoFCFM-BUAP Alma Xochitl Gonzalez MoralesInstituto de Ciencias Nucleares, UNAM Andrew Walcott BeckwithAmerican Institute of Beam Energy Physics Ariadna Montiel ArenasDepartamento de Física, CINVESTAV Arnulfo ZepedaCinvestav Arturo Alvarez CruzInstituto de Fisica, UNAM Axel de la MacorraUNAM, IAC Azar MustafayevUniversity of Minnesota Benjamin JaramilloDCI-UG Vincent BertinCPPM-Marseille Carlos Alberto Vaquera-AraujoDCI-UG Carlos MuñozMadrid Autonoma U. & Madrid, IFT Carmine PagliaroneINFN, FNAL Carolina Lujan PeschardDCI-UG Christiane Frigerio MartinsUniversidade Federal do ABC-São Paulo Csaba BalazsMonash University David DelepineDCI-UG David G CerdenoUniversidad Autonoma de Madrid & Instituto de Fisica Teorica Debasish MajumdarSaha Institute of Nuclear Physics, Kolkata, India Dibyendu PanigrahiKandi Raj College, Kandi, Murshidabad, INDIA-742137 Dupret Alberto Santana BejaranoUniversidad de Sonora Departamento de Investigacion en Fisica Ernest MaRiverside U.C. Esteban Alejandro Reyes Pírez MontañezInstituto de Física, UNAM Federico Ortiz TrejoINSTITUTO DE ASTRONOMÍA - UNAM Francisco José de Anda NavarroUniversidad de Guadalajara González Alvarez Francisco JavierCINVESTAV-Depto. Física Gustavo Medina TancoICN-UNAM Hernando Efrain Caicedo OrtizInstituto Politecnico Nacional - IPN J D VergadosCERN & Ioannina U. James R BoyceJefferson Lab Jason SteffenFERMILAB Javier Montaño DomínguezDCI-UG Jeevan SolankiMandsaur Institue of Technology MP India Joe SatoSaitama University Jorge Luis Navarro EstradaUNAM-ICN and Universidad del Atlantico (B/quilla-Col.) Jose A R CembranosUniversity of Minnesota José DíazIFIC Jose Didino Garcia AguilarDepto. de Fisica. Cinvestav Keith OliveUniversity of Minnesota Konstantia BalasiUniversity of Ioannina, Greece Lilian Prado

  15. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial

    PubMed Central

    Vinks, Alexander A.; Fukuda, Tsuyoshi; King, Eileen C.; Zou, Yuanshu; Jiang, Wenlei; Klawitter, Jelena; Christians, Uwe

    2017-01-01

    Background Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients. Several professional transplant societies and publications have generated skepticism of the generic approval process. Three major areas of concern are that the pharmacokinetic properties of generic products and the innovator (that is, “brand”) product in healthy volunteers may not reflect those in transplant recipients, bioequivalence between generic and innovator may not ensure bioequivalence between generics, and high-risk patients may have specific bioequivalence concerns. Such concerns have been fueled by anecdotal observations and retrospective and uncontrolled published studies, while well-designed, controlled prospective studies testing the validity of the regulatory bioequivalence testing approach for narrow therapeutic index immunosuppressants in transplant recipients have been lacking. Thus, the present study prospectively assesses bioequivalence between innovator tacrolimus and 2 generics in individuals with a kidney or liver transplant. Methods and findings From December 2013 through October 2014, a prospective, replicate dosing, partially blinded, randomized, 3-treatment, 6-period crossover bioequivalence study was conducted at the University of Cincinnati in individuals with a kidney (n = 35) or liver transplant (n = 36). Abbreviated New Drug Applications (ANDA) data that included manufacturing and healthy individual pharmacokinetic data for all generics were evaluated to select the 2 most disparate generics from innovator, and these were named Generic Hi and Generic Lo. During the 8-week study period, pharmacokinetic studies assessed the bioequivalence of Generic Hi and Generic Lo with the Innovator tacrolimus and with each other. Bioequivalence of the major tacrolimus metabolite was also assessed. All products fell within

  16. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

    PubMed

    Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; King, Eileen C; Zou, Yuanshu; Jiang, Wenlei; Woodle, E Steve; Tremblay, Simon; Klawitter, Jelena; Klawitter, Jost; Christians, Uwe

    2017-11-01

    Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients. Several professional transplant societies and publications have generated skepticism of the generic approval process. Three major areas of concern are that the pharmacokinetic properties of generic products and the innovator (that is, "brand") product in healthy volunteers may not reflect those in transplant recipients, bioequivalence between generic and innovator may not ensure bioequivalence between generics, and high-risk patients may have specific bioequivalence concerns. Such concerns have been fueled by anecdotal observations and retrospective and uncontrolled published studies, while well-designed, controlled prospective studies testing the validity of the regulatory bioequivalence testing approach for narrow therapeutic index immunosuppressants in transplant recipients have been lacking. Thus, the present study prospectively assesses bioequivalence between innovator tacrolimus and 2 generics in individuals with a kidney or liver transplant. From December 2013 through October 2014, a prospective, replicate dosing, partially blinded, randomized, 3-treatment, 6-period crossover bioequivalence study was conducted at the University of Cincinnati in individuals with a kidney (n = 35) or liver transplant (n = 36). Abbreviated New Drug Applications (ANDA) data that included manufacturing and healthy individual pharmacokinetic data for all generics were evaluated to select the 2 most disparate generics from innovator, and these were named Generic Hi and Generic Lo. During the 8-week study period, pharmacokinetic studies assessed the bioequivalence of Generic Hi and Generic Lo with the Innovator tacrolimus and with each other. Bioequivalence of the major tacrolimus metabolite was also assessed. All products fell within the US Food and Drug Administration

  17. [Study on psychiatric disorders and defensive process assessed by the "defense style questionnaire" in sterile males SAMPLE consulting in andrology].

    PubMed

    Bellone, M; Cottencin, O; Rigot, J M; Goudemand, M

    2005-01-01

    that additional prospective studies, which would permit to make a link between the defense mechanisms anda certain psychiatric pathology, are necessary. In the case we study, it is important to explore the defensive modalities before the infertility diagnosis and after the birth of a child, with a more important sample population. A better knowledge of the defensive modalities of such a population, used in a psychotherapeutic context could help to prevent the appearance of psychiatric disorders or, if not, to anticipate them.

  18. Solar tidal variations of coefficients of second harmonic of gravitational potential of Mercury

    NASA Astrophysics Data System (ADS)

    Ferrandiz, Jose; Barkin, Yury

    2010-05-01

    ratio of mass of the Sun and Mercury m-M = 6023600, mean radius of Mercury R = 2439.7 km. a = 0.3870983098 AU is an unperturbed value of major semi-axis of Mercury orbit. k2=0.37. αjis direction cosines of the radius-vector of the Sun in Mercury principal axes of inertia. The central problem of the work was a construction of trigonometric developments of the producta and squares of these direction cosines multiplied on function(a-r)3, where r is a value of radius-vector of the Sun anda is a major semi-axis of orbit of Mercury (unperturbed value): (a-r)3αiαj. Omiting sufficiently long procedure on construction of developments for mentioned products we present final formulas for solar tidal variations of coefficients of Mercury gravitational potential: M--(R-)3Σ δJ2 = - 3k2m a [R0,ν(ρ,t)cos? ν + r0,ν(ρ,t)sin ?ν] ν ( ) 1 M-- R- 3Σ Σ [ (ɛ) (ɛ) ] δS22 = - 8k2m a R2,ν cos(2g +2l- ɛ? ν)- r2,ν sin (2g - ɛ?ν) , ν ɛ 1 M (R )3Σ Σ [ (ɛ) (ɛ) ] δC21 = - 4k2m- -a R1,ν cos (g + l- ɛ? ν)- r1,ν sin(g+ l- ɛ?ν) , ν ɛ ( )3Σ Σ [ ] δS21 = - 1 k2 M- R- R (ɛ1,)ν cos(g+ l- ɛ?ν)- r(1ɛ),ν sin(g- ɛ? ν). 4 m a ν ɛ For simplicity here we put the value of the angle ? = 00, that means that in unperturbed rotational motion of Mercury its vector of angular momentum consides with the polar principial axis of inertia. Here ɛ = ±1; ?ν are arguments located on multiple of mean longitudes of planets (Mercury, Venus, the Earth, Mars, Jupiter, Saturn, Uran and the Neptune): ?ν = ν1LMe + ν2LV + ν3LE + ν4LMa + ν5LJu + ν6LSa + ν7LUr + ν8LNe; ν = (ν1,ν2,ν3,...,ν8) are corresponding sets of integer indexes. Here all functions R and r are special inclination functions depending from angle ρof inclination of vector of angular momentum of Mercury with respect to normal to base (Laplace) plane and coefficients:Aν(j), Bν(j) and aν(j), bν(j): R0,ν(ρ,t) = - 1 (3 cos2ρ - 1)A(ν0)- 1sin2ρA(ν1)- 1sin2ρA(ν2), 6 2 4 1 ( ) 1 1 r0,ν(ρ,t) = -- 3cos2

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