Temporal changes in tongue color as criterion for tongue diagnosis in Kampo medicine.

PubMed

Yamamoto, Satoshi; Ishikawa, Yuya; Nakaguchi, Toshiya; Ogawa-Ochiai, Keiko; Tsumura, Norimichi; Kasahara, Yuji; Namiki, Takao; Miyake, Yoichi

2012-01-01

In Kampo medicine (Japanese traditional herbal medicine), the appearance of the tongue contains a lot of useful information for diagnosis. However, an inspection of the tongue is not considered to be important in modern medical diagnosis, since the skills applied in the examination are difficult to understand. Thus, we developed an imaging system and algorithm for quantitative analysis of the tongue to provide the traditional techniques of Kampo with greater objectivity. Tongue images were taken from 9 healthy subjects for 3 consecutive weeks (5 days/week), 12 times a day, with 300 images taken successively within 30 s each time. Then, the temporal color changes in 30 s, 1 day, and 3 weeks were measured in the device-independent International Commission on Illumination (CIE) 1976 L*a*b* color space. The tongue color change in 30 s varied between individuals, and it was mainly classified into 3 patterns. This image acquisition system and valid color management should help all tongue-related research, and the 30-s temporal color change might be an important target for further tongue analysis. We were able to acquire tongue images without specular reflection and with valid color reproduction, and the color change in 30 s was found to vary. Tongue color changes have not been mentioned in the classics of Kampo medicine, since they were certainly impossible to discriminate by the naked eye. The change during 30 s is a new finding based on the electronic devices, and together they are expected to become a new criterion for tongue analysis. Copyright © 2012 S. Karger AG, Basel.

An accidental case of aconite poisoning due to Kampo herbal medicine ingestion.

PubMed

Ono, Takiyoshi; Hayashida, Makiko; Uekusa, Kyoko; Lai, Cui Fan; Hayakawa, Hideyuki; Nihira, Makoto; Ohno, Youkichi

2009-05-01

An accidental case of aconite intoxication occurred after a patient took a therapeutic dose of Kampo herbal medicine containing Aconiti tuber, Uzu but had used the wrong decoction procedure. The poisoning was likely caused by an increased level of Aconitum alkaloids in the decoction; the patient developed aconite intoxication due to incomplete decoction. Aconitum alkaloid levels in the leftover solution which the patient had drunk and in the decoction extracted from 3g Uzu were determined. It was found that decoction makes the medicine safer to drink. Older individuals, especially those with dementia, have a higher risk of aconite poisoning because they sometimes do not boil the medicine appropriately.

Anticancer effect of a Kampo preparation Daikenchuto.

PubMed

Nagata, Takuya; Toume, Kazufumi; Long, Lv Xiao; Hirano, Katsuhisa; Watanabe, Toru; Sekine, Shinichi; Okumura, Tomoyuki; Komatsu, Katsuko; Tsukada, Kazuhiro

2016-07-01

No traditional Japanese and Chinese herbal preparations have been shown to be effective antitumor agents, and a Japanese herbal therapy (Kampo medicine) for cancer that causes fewer adverse drug reactions than orthodox pharmaceuticals is desired. Our present study demonstrated that a Kampo preparation Daikenchuto (DKT) exerts an antitumor effect against various cancer cells. We also discovered an antitumor factor in Japanese Zanthoxylum peel, which is an ingredient of DKT. Breast, esophageal, gastric, and colon cancer cell lines were individually incubated with DKT for 1-72 h, followed by assessment of tumor growth inhibition by MTT assay. The cancer cells were also analyzed for apoptotic changes after DKT treatment. Nude mice were used to establish a model of gastric cancer tumor growth and peritoneal disseminated metastasis, in which the number of peritoneal disseminations was evaluated after oral administration of DKT for 4 weeks. In addition, the antitumor effects of the individual DKT ingredients (viz., ginseng, Japanese Zanthoxylum peel, and processed ginger) and other Kampo preparations were also analyzed. The antitumor effect of DKT was demonstrated in gastric, breast, esophageal, and colon cancer cells. DKT treatment induced apoptosis in these cells. Oral administration of DKT had a tendency to reduce the growth and significantly reduced the peritoneal dissemination of gastric cancer in the nude mouse model compared with control. DKT exhibited a higher antitumor effect than other Kampo preparations. Furthermore, Japanese Zanthoxylum peel, an ingredient of DKT, showed a particularly potent antitumor effect. Our study indicated that DKT is useful as a Kampo preparation for cancer therapy. We also showed that Japanese Zanthoxylum peel, an ingredient of DKT, contains an antitumor factor.

Does a kampo medicine containing schisandra fruit affect pharmacokinetics of nifedipine like grapefruit juice?

PubMed

Makino, Toshiaki; Mizuno, Fumika; Mizukami, Hajime

2006-10-01

Herb-drug interaction has attracted attention as medicinal topics recently. However, the drug information is sometimes confusing. Previous in vitro studies revealed that schisandra fruit had strong inhibitory effect on CYP3A4 and claimed the possibilities of its herb-drug interaction. In the present study, we evaluated the inhibitory effects of schisandra fruit and shoseiryuto, an herbal formula in Japanese traditional kampo medicine containing eight herbal medicines including schisandra fruit, on rat CYP3A activity in vitro, and the effect of shoseiryuto on pharmacokinetics of nifedipine in rats, in comparison with those of grapefruit juice, a well-characterized natural CYP3A inhibitor. Shoseiryuto and its herbal constituents, schisandra fruit, ephedra herb and cinnamon bark exhibited in vitro inhibitory effect of CYP3A. Although shoseiryuto inhibited rat CYP3A activity in vitro with a degree comparable to grapefruit juice, shoseiryuto did not significantly affect a plasma concentration profile of nifedipine in rats as grapefruit juice did. These results indicate that in vivo experiments using the extract of herbal medicine prepared with the same dosage form as patients take are necessary to provide proper information about herb-drug interaction.

The kampo medicine Daikenchuto inhibits peritoneal fibrosis in mice.

PubMed

Kitamura, Mineaki; Nishino, Tomoya; Obata, Yoko; Oka, Satoru; Abe, Shinichi; Muta, Kumiko; Ozono, Yoshiyuki; Koji, Takehiko; Kohno, Shigeru

2015-01-01

Long-term peritoneal dialysis therapy causes inflammation and histological changes in the peritoneal membrane. Inflammation generally activates fibroblasts and results in fibroblast-myofibroblast differentiation. Heat-shock protein 47 (HSP 47), a collagen-specific molecular chaperone, is localized in myofibroblasts and is involved in the progression of peritoneal fibrosis. Daikenchuto (DKT), a Kampo medicine, is used to prevent postoperative colon adhesion. It inhibits inflammation and HSP 47 expression in the gastrointestinal tract. We examined the effect of DKT on chlorhexidine gluconate (CG)-induced peritoneal fibrosis in mice injected with 0.1% CG dissolved in 15% ethanol. DKT was dissolved in the drinking water. Histological changes were assessed using Masson trichrome staining. Cells expressing α-smooth muscle actin (α-SMA), HSP 47, phospho-Smad 2/3, F4/80, and monocyte chemotactic protein-1 were examined immunohistochemically. Compared with the control group, the peritoneal tissues of the CG group were markedly thickened, and the number of cells expressing α-SMA, HSP 47, phospho-Smad 2/3, F4/80, and monocyte chemotactic protein-1 was significantly increased. However, these changes were inhibited in the DKT-treated group. These results indicate that DKT can prevent peritoneal fibrosis by inhibiting inflammation and HSP 47 expression.

Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood-brain barrier.

PubMed

Iwanaga, Kazunori; Yoneda, Shinji; Hamahata, Yukimi; Miyazaki, Makoto; Shibano, Makio; Taniguchi, Masahiko; Baba, Kimiye; Kakemi, Masawo

2011-01-01

Furanocoumarin derivatives, known as components of grapefruit juice, showing inhibitory effects against P-glycoprotein (P-gp) in the intestine are also contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of byakangelicol and rivulobirin A, known as furanocoumarins showing P-gp inhibitory effect using Caco-2 monolayer, against P-gp at the blood-brain barrier (BBB) under both in vitro and in vivo conditions. First we studied the membrane permeability of furanocoumarins to clarify whether they can be absorbed from the intestine. Both furanocoumarins showed high permeability through the Caco-2 monolayer, suggesting that they can easily reach the systemic circulation after oral administration. Then, we evaluated the effect of these furanocoumarins on the uptake of calcein acetoxymethyl ester (calcein-AM), a P-gp substrate, into bovine brain microvascular endothelial cells (BBMEC). Both furanocoumarins significantly increased the uptake amount of calcein-AM into BBMEC by the inhibition of P-gp at the BBB in vitro. Next we also investigated the P-gp inhibitory effect of these furanocoumarins at the rat BBB in vivo using verapamil as a P-gp substrate. Both furanocoumarins increased the B/P ratio of verapamil compared to the control, even under in vivo conditions; however, the extent of the inhibitory effect was much lower than in vitro condition. In conclusion, byakangelicol and rivulobirin A may inhibit P-gp expressed at the BBB even under in vivo conditions. Further studies using Kampo extract medicines under in vivo condition are necessary for safe drug therapy.

Potential Usefulness of the Kampo Medicine Yokukansan, Containing Uncaria Hook, for Paediatric Emotional and Behavioural Disorders: A Case Series

PubMed Central

2013-01-01

Background. Paediatric emotional and behavioural disorders (EBD) are relatively common diseases. Although nonpharmacologic and pharmacologic treatments are utilized in these cases, it is sometimes difficult to manage the symptoms of EBD. Historically, Uncaria hook has been used for treating nighttime crying and convulsions in children. Recent clinical studies have demonstrated that the Kampo medicine Yokukansan (YKS), which contains Uncaria hook, is efficacious for behaviour disorders in Alzheimer's disease patients. Herein, we investigated the clinical efficacy and safety of YKS in a series of cases with paediatric EBD. Patients and Methods. We retrospectively reviewed all paediatric patients who sought Japanese Kampo therapy at our outpatient clinics between April 1, 2012, and April 30, 2013; we selected patients who were diagnosed with paediatric EBD and were treated with YKS. Results. After screening all candidates, 3 patients were eligible for this analysis. Their average age was 11.6 years (range 10–13 years). All 3 patients responded very well to YKS within 1 month. No drug-related adverse events were observed during the course of YKS treatment. Conclusion. Yokukansan may be efficacious for paediatric EBD. We believe these results warrant further evaluation of the clinical efficacy and safety of Yokukansan for paediatric EBD in a carefully designed, double-blind, randomized clinical study. PMID:24204394

Deconstructing the traditional Japanese medicine "Kampo": compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms.

PubMed

Nishi, Akinori; Ohbuchi, Katsuya; Kushida, Hirotaka; Matsumoto, Takashi; Lee, Keiko; Kuroki, Haruo; Nabeshima, Shigeki; Shimobori, Chika; Komokata, Nagisa; Kanno, Hitomi; Tsuchiya, Naoko; Zushi, Makoto; Hattori, Tomohisa; Yamamoto, Masahiro; Kase, Yoshio; Matsuoka, Yukiko; Kitano, Hiroaki

2017-01-01

Pharmacological activities of the traditional Japanese herbal medicine (Kampo) are putatively mediated by complex interactions between multiple herbal compounds and host factors, which are difficult to characterize via the reductive approach of purifying major bioactive compounds and elucidating their mechanisms by conventional pharmacology. Here, we performed comprehensive compound, pharmacological and metabolomic analyses of maoto, a pharmaceutical-grade Kampo prescribed for flu-like symptoms, in normal and polyI:C-injected rats, the latter suffering from acute inflammation via Toll-like receptor 3 activation. In total, 352 chemical composition-determined compounds (CCDs) were detected in maoto extract by mass spectrometric analysis. After maoto treatment, 113 CCDs were newly detected in rat plasma. Of these CCDs, 19 were present in maoto extract, while 94 were presumed to be metabolites generated from maoto compounds or endogenous substances such as phospholipids. At the phenotypic level, maoto ameliorated the polyI:C-induced decrease in locomotor activity and body weight; however, body weight was not affected by individual maoto components in isolation. In accordance with symptom relief, maoto suppressed TNF-α and IL-1β, increased IL-10, and altered endogenous metabolites related to sympathetic activation and energy expenditure. Furthermore, maoto decreased inflammatory prostaglandins and leukotrienes, and increased anti-inflammatory eicosapentaenoic acid and hydroxyl-eicosapentaenoic acids, suggesting that it has differential effects on eicosanoid metabolic pathways involving cyclooxygenases, lipoxygenases and cytochrome P450s. Collectively, these data indicate that extensive profiling of compounds, metabolites and pharmacological phenotypes is essential for elucidating the mechanisms of herbal medicines, whose vast array of constituents induce a wide range of changes in xenobiotic and endogenous metabolism.

Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence.

PubMed

Matsumoto, Kinzo; Zhao, Qi; Niu, Yimin; Fujiwara, Hironori; Tanaka, Ken; Sasaki-Hamada, Sachie; Oka, Jun-Ichiro

2013-01-01

Cognitive deficits and behavioral and psychological symptoms of dementia (BPSD) are typical features of patients with dementia such as Alzheimer's disease (AD), vascular dementia (VD), and other forms of senile dementia. Clinical evidence has demonstrated the potential usefulness of chotosan (CTS) and yokukansan (YKS), traditional herbal formulations called Kampo medicines, in the treatment of cognitive disturbance and BPSD in dementia patients, although the indications targeted by CTS and YKS in Kampo medicine differ. The availability of CTS and YKS for treating dementia patients is supported by preclinical studies using animal models of dementia that include cognitive/emotional deficits caused by aging and diabetes, dementia risk factors. These studies have led not only to the concept of a neuronal basis for the CTS- and YKS-induced amelioration of cognitive function and emotional/psychiatric symptom-related behavior in animal models, but also to a proposal that ingredient(s) of Uncariae Uncis cum Ramulus, a medicinal herb included in CTS and YKS, may play an important role in the actions of these formulae in dementia patients. Further studies are needed to clarify the active ingredients of these formulae and their target endogenous molecules implicated in the anti-dementia drug-like actions.

Traditional Japanese medicines inhibit compound action potentials in the frog sciatic nerve.

PubMed

Matsushita, Akitomo; Fujita, Tsugumi; Ohtsubo, Sena; Kumamoto, Eiichi

2016-02-03

Traditional Japanese (Kampo) medicines have a variety of clinical effects including pain alleviation, but evidence for a mechanism for their pain relief has not yet been elucidated fully. Considering that Kampo medicine contains many plant-derived chemicals having an ability to inhibit nerve action potential conduction, it is possible that this medicine inhibits nerve conduction. The purpose of the present study was to know how various Kampo medicines affect nerve conduction. We examined the effects of Kampo and crude medicines on compound action potentials (CAPs) recorded from the frog sciatic nerve by using the air-gap method. Daikenchuto, rikkosan, kikyoto, rikkunshito, shakuyakukanzoto and kakkonto concentration-dependently reduced the peak amplitude of the CAP. Among the Kampo medicines, daikenchuto was the most effective in inhibiting CAPs. Daikenchuto is composed of three kinds of crude medicine, Japanese pepper, processed ginger and ginseng radix. When the crude medicines were tested, Japanese pepper and processed ginger reduced CAP peak amplitudes, while ginseng radix hardly affected CAPs. Moreover, there was an interaction between the Japanese pepper and processed ginger activities in such that one medicine at low but not high concentrations increased the extent of the inhibition by the other one that was co-applied. Kampo medicines have an ability to inhibit nerve conduction. This action of daikenchuto is due to Japanese pepper and processed ginger but not ginseng radix, probably through an interaction between Japanese pepper and processed ginger in a manner dependent on their concentrations. Nerve conduction inhibition could contribute to at least a part of Kampo medicine's clinical effects such as pain alleviation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Web-Based Evaluation System to Measure Learning Effectiveness in Kampo Medicine

PubMed Central

Usuku, Koichiro; Segawa, Makoto; Wang, Yue; Ogashiwa, Kahori; Fujita, Yusuke; Ogihara, Hiroyuki; Tazuma, Susumu

2016-01-01

Measuring the learning effectiveness of Kampo Medicine (KM) education is challenging. The aim of this study was to develop a web-based test to measure the learning effectiveness of KM education among medical students (MSs). We used an open-source Moodle platform to test 30 multiple-choice questions classified into 8-type fields (eight basic concepts of KM) including “qi-blood-fluid” and “five-element” theories, on 117 fourth-year MSs. The mean (±standard deviation [SD]) score on the web-based test was 30.2 ± 11.9 (/100). The correct answer rate ranged from 17% to 36%. A pattern-based portfolio enabled these rates to be individualized in terms of KM proficiency. MSs with scores higher (n = 19) or lower (n = 14) than mean ± 1SD were defined as high or low achievers, respectively. Cluster analysis using the correct answer rates for the 8-type field questions revealed clear divisions between high and low achievers. Interestingly, each high achiever had a different proficiency pattern. In contrast, three major clusters were evident among low achievers, all of whom responded with a low percentage of or no correct answers. In addition, a combination of three questions accurately classified high and low achievers. These findings suggest that our web-based test allows individual quantitative assessment of the learning effectiveness of KM education among MSs. PMID:27738440

Web-Based Evaluation System to Measure Learning Effectiveness in Kampo Medicine.

PubMed

Iizuka, Norio; Usuku, Koichiro; Nakae, Hajime; Segawa, Makoto; Wang, Yue; Ogashiwa, Kahori; Fujita, Yusuke; Ogihara, Hiroyuki; Tazuma, Susumu; Hamamoto, Yoshihiko

2016-01-01

Measuring the learning effectiveness of Kampo Medicine (KM) education is challenging. The aim of this study was to develop a web-based test to measure the learning effectiveness of KM education among medical students (MSs). We used an open-source Moodle platform to test 30 multiple-choice questions classified into 8-type fields (eight basic concepts of KM) including "qi-blood-fluid" and "five-element" theories, on 117 fourth-year MSs. The mean (±standard deviation [SD]) score on the web-based test was 30.2 ± 11.9 (/100). The correct answer rate ranged from 17% to 36%. A pattern-based portfolio enabled these rates to be individualized in terms of KM proficiency. MSs with scores higher ( n = 19) or lower ( n = 14) than mean ± 1SD were defined as high or low achievers, respectively. Cluster analysis using the correct answer rates for the 8-type field questions revealed clear divisions between high and low achievers. Interestingly, each high achiever had a different proficiency pattern. In contrast, three major clusters were evident among low achievers, all of whom responded with a low percentage of or no correct answers. In addition, a combination of three questions accurately classified high and low achievers. These findings suggest that our web-based test allows individual quantitative assessment of the learning effectiveness of KM education among MSs.

Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice.

PubMed

Ono, Masafumi; Ogasawara, Mitsunari; Hirose, Akira; Mogami, Sachiko; Ootake, Nobuhiro; Aritake, Kosuke; Higuchi, Takuma; Okamoto, Nobuto; Sakamoto, Shuji; Yamamoto, Masahiro; Urade, Yoshihiro; Saibara, Toshiji; Oben, Jude A

2014-06-01

Obesity-induced liver disease (nonalcoholic fatty liver disease, NAFLD) is now the commonest cause of chronic liver disease in affluent nations. There are presently no proven treatments for NAFLD or its more severe stage, nonalcoholic steatohepatitis (NASH). Bofutsushosan (BTS), a Japanese herbal (Kampo) medicine, long used as an anti-obesity medicine in Japan and other Asian countries, has been shown to reduce body weight and improve insulin resistance (IR) and hepatic steatosis. The precise mechanism of action of BTS, however, remains unclear. To evaluate the ability of BTS to prevent the development of NASH, and determine the mediators and pathways involved. C57BL/6 mice were injected intra-peritoneally with gold-thioglucose and fed a high-fat diet (HF) or HF diet admixed with either 2 or 5 % BTS for 12 weeks. The effectiveness of BTS in attenuating features of NASH and the mechanisms through which BTS attenuated NASH were then assayed through an assessment of the anthropometric, radiological, biochemical and histological parameters. BTS attenuated the progression of NASH through induction of adiponectin and its receptors along with an induction of PPAR-α and PPAR-γ, decreased expression of SREBP-1c, increased hepatic fatty acid oxidation and increased hepatic export of triglycerides. BTS moreover, reduced IR through phosphorylation of the protein kinase, Akt. BTS through induction of adiponectin signaling and Akt attenuated development of NASH. Identification of the active entity in BTS should allow development of novel treatments for NASH.

Kampo medicine "Dai-kenchu-to" prevents CPT-11-induced small-intestinal injury in rats.

PubMed

Chikakiyo, Motoya; Shimada, Mitsuo; Nakao, Toshihiro; Higashijima, Jun; Yoshikawa, Kozo; Nishioka, Masanori; Iwata, Takashi; Kurita, Nobuhiro

2012-01-01

The key anticancer agent, CPT-11 (irinotecan hydrochloride), induces severe diarrhea clinically. We investigated the effect of a Kampo medicine, Dai-kenchu-to (DKT), on CPT-11-induced intestinal injuries in rats. Twenty-four male Wistar rats were divided into three groups: a control group; a CPT-11 group, given CPT-11 150 mg/kg intraperitoneally for 2 days; and a DKT group, given DKT 300 mg/kg orally for 5 days with CPT-11 150 mg/kg intraperitoneally on days 4 and 5. The rats were killed on day 6. Interleukin (IL)-1β, IL-12, interferon (IFN)-γ, and tumor necrosis factor-α expression in the small intestine of the CPT-11 group was significantly higher than that of the control group. Interleukin-1β and IFN-γ expression was improved significantly by DKT (P < 0.05). The number and height of jejuna villi, injury score, and apoptosis index in the CPT-11 group were improved significantly by DKT (P < 0.05). DKT suppressed CPT-11 induced inflammatory cytokines and apoptosis in the intestinal mucosa and maintained the mucosal integrity.

Inhibitory effects of Atractylodis lanceae rhizoma and Poria on collagen- or thromboxane A2-induced aggregation in rabbit platelets.

PubMed

Nasu, Yuiko; Iwashita, Masaya; Saito, Masaki; Fushiya, Shinji; Nakahata, Norimichi

2009-05-01

Kami-shoyo-san (Jia-Wei-Xiao-Yao-San), Toki-shakuyaku-san (Dang-Gui-Shao-Yao-San) and Toki-shigyaku-ka-goshuyu-shokyo-to (Dang-Gui-Si-Ni-Jia-Wu-Zhu-Yu-Sheng-Jiang-Tang) are Kampo (traditional Chinese) medicines which are traditionally and effectively used for the treatment of chilly sensation (Hiesho) in Japan, but the active components and their detailed mechanisms have not yet been clarified. Etiologies of Hiesho include poor peripheral blood circulation and platelet aggregability contributes to peripheral blood circulation; therefore, we investigated the effect of Kampo medicines on platelet aggregation using rabbit platelets in vitro. Collagen and U46619, a thromboxane A(2) receptor agonist, caused rabbit platelet aggregation, which was potently inhibited by pretreatment of platelets with Kami-shoyo-san and Toki-shakuyaku-san in vitro. Toki-shigyaku-ka-goshuyu-shokyo-to, however, did not significantly inhibit collagen- or U46619-induced platelet aggregation. Therefore, we examined the effect on platelet aggregation of two herbal medicines, Atractylodis Lanceae Rhizoma and Poria, both of which are contained in Kami-shoyo-san and Toki-shakuyaku-san but not in Toki-shigyaku-ka-goshuyu-shokyo-to. As the results indicate, Atractylodis Lanceae Rhizoma inhibited platelet aggregation induced by collagen but not by U46619. Poria effectively inhibited U46619-induced platelet aggregation and it partially inhibited collagen-induced platelet aggregation. On the other hand, Atractylodis Lanceae Rhizoma and Poria did not inhibit adrenaline/adenosine diphosphate- or adrenaline/serotonin-induced platelet aggregation. These results suggest the possibility that the inhibition of platelet aggregation by two Kampo medicines, Kami-shoyo-san and Toki-shakuyaku-san, is one of the mechanisms underlying the improvement of Hiesho. Furthermore, Atractylodis Lanceae Rhizoma and Poria are possible herbal medicines for the inhibition of platelet aggregation.

Changes in serum tumor necrosis factor (TNF-alpha) with kami-shoyo-san administration in depressed climacteric patients.

PubMed

Ushiroyama, Takahisa; Ikeda, Atsushi; Sakuma, Kou; Ueki, Minoru

2004-01-01

An herbal medicine (kampo) is widely used to prevent or treat climacteric symptoms. In order to investigate the potential involvement of tumor necrosis factor (TNF)-alpha in susceptibility to mood disorder in climacteric women and to clarify the relationship between immune function and the efficacy of herbal medicine, we compared serum TNF-alpha levels in two treated groups, with and without concurrent use of herbal medicine. This study included 113 consecutive depressed menopausal patients who visited the gynecological and psychosomatic medicine outpatient clinic of the Osaka Medical College Hospital in Japan. Fifty-eight patients were administered kami-shoyo-san according to the definition of above sho. In contrast, 55 patients who were different in sho of kami-shoyo-san were administered antidepressants. Hamilton Rating Scale for depression (HAM-D) scores were determined at baseline and 12 weeks after starting treatment (endpoint). TNF-alpha concentrations were analyzed before and after 12 weeks of treatment. Kami-shoyo-san significantly increased plasma concentrations of TNF-alpha after 12 weeks of treatment, to 17.22 +/- 6.13 pg/ml from a baseline level of 14.16 +/- 6.27 pg/ml (p = 0.048). The percent change in plasma concentration of TNF-alpha differed significantly between the kami-shoyo-san therapy group and the antidepressant therapy group at 4 weeks (12.0 +/- 7.8% and -1.22 +/- 0.25%, respectively, p < 0.01), 8 weeks (19.7 +/- 3.4% and -2.45 +/- 0.86%, respectively, p < 0.01), and 12 weeks (21.3 +/- 5.4% and -6.81 +/- 2.2%, respectively, p < 0.001). We found in this study that kami-shoyo-san, an herbal medicine, increased plasma TNF-alpha levels in depressed menopausal patients. Cytokines may play various roles in mood and emotional status via the central nervous system and may be regulated by herbal medicines, although the interactions are very complex.

Evaluation of medical students using the "qi, blood, and fluid" system of Kampo medicine.

PubMed

Arai, Makoto; Arai, Katsuhiko; Hioki, Chizuko; Takashi, Masanori; Matsumoto, Kaori; Honda, Masamitsu; Izumi, Shun-ichiro

2013-04-20

Although "qi, blood, and fluid" (QBF) is the most important concept for patients in Kampo medicine, there are few studies about the conditions of the QBF system among healthy populations. We used QBF pattern scores to determine whether or not medical students, presumed to be healthy, had any potentially pathological conditions. Six consecutive fourth-year classes totaling 652 medical students evaluated their own QBF conditions using Terasawa's QBF pattern scores. The six conditions: "qi deficiency" (QD), "qi stagnation" (QS), "qi counterflow" (QC), "blood deficiency" (BD), "blood stasis" (BS), and "fluid disturbance" (FD), were categorized according to Terasawa's criteria. The Mann-Whitney U test was used to compare the score differences between the genders, Chi-square test was used to examine gender differences in the QBF diagnoses, and the Spearman's rank-order correlation coefficient analysis was used to analyze the correlation between each category of QBF. In all, 44.6% of the students met at least one diagnostic criterion in the QBF system. QC, BD, BS, and FD were established more in females, and QD and QS were established without gender differences. Most students who were presumed to be healthy were revealed to have some potentially pathological conditions using the QBF system.

Extra-weak chemiluminescence produced by autoxidation of kampo extract preparations stored in heat-stressed conditions.

PubMed

Sato, H; Hirayama, H; Yamamoto, T; Ishizawa, F; Mizugaki, M

1998-06-01

The purpose of this study was to evaluate the usefulness of extra-weak chemiluminescence (CL) measurement as a rapid method to estimate the stability of Kampo extract preparations. It was found that the Kampo drugs that emit little CL were stable, while those with higher CL were comparatively unstable with regard to the various stability markers, including change of coloration (browning), contents of specific ingredients, high molecular compounds, amino acids and sugars under various conditions of heat storage. Excellent correlation existed between the CL of Kampo drugs and the coloration (delta E* (ab)) and the other above-mentioned evaluation markers. From this investigation, it was deduced that the CL of Kampo drugs originates in the early stage of the Maillard reaction and reflects the stability of the preparations, and that CL is useful for estimating the stability of Kampo drugs.

A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds.

PubMed

Uchi, Hiroshi; Tokunaga, Shoji; Mitoma, Chikage; Shibata, Satoko; Hamada, Naoki; Nakanishi, Yoichi; Kajiwara, Junboku; Yoshimura, Takesumi; Furue, Masutaka

2011-01-01

The objective of this study was to evaluate the effectiveness of traditional herbal medicines (Kampo) on the symptoms of Yusho. Yusho is a mass food poisoning that was caused by ingestion of rice oil contaminated with dioxins and related organochlorines in 1968. Patients with Yusho suffer from skin symptoms (acneform eruptions, liability to suppuration and pigmentation), respiratory symptoms (cough and expectoration of sputum), neurological symptoms (numbness and paresthesia of extremities), arthralgia and general fatigue, and no effective treatment has yet been developed. In this clinical trial, four Kampo formulae (Bakumondo-to, Keigai-rengyo-to, Gosha-jinki-gan and Hochu-ekki-to) were administered to four representative Yusho symptoms (respiratory, skin, neurological symptoms and general fatigue), respectively. Twenty-seven Yusho patients were enrolled and two formulae were administered to each patient for half-a-year each. The effectiveness of Kampo formulae was estimated by changes in the intensity of symptoms measured by a visual analogue scale (VAS) of 100 mm recorded at baseline and after administration of each formula. The influence of Kampo formulae on patients' quality of life (QOL) was also assessed by the SF-36 (NBS). Twenty-five patients completed the treatment. Bakumondo-to significantly improved respiratory symptoms as well as patients' QOL in the context of vitality, compared with other formulae. In contrast, Hochu-ekki-to impaired patients' QOL in the context of physical functioning and vitality, compared with other formulae. This study demonstrated for the first time that a Kampo formula Bakumondo-to is useful for treating respiratory symptoms caused by dioxins.

A Clinical Trial of Kampo Formulae for the Treatment of Symptoms of Yusho, a Poisoning Caused by Dioxins and Related Organochlorine Compounds

PubMed Central

Uchi, Hiroshi; Tokunaga, Shoji; Mitoma, Chikage; Shibata, Satoko; Hamada, Naoki; Nakanishi, Yoichi; Kajiwara, Junboku; Yoshimura, Takesumi; Furue, Masutaka

2011-01-01

The objective of this study was to evaluate the effectiveness of traditional herbal medicines (Kampo) on the symptoms of Yusho. Yusho is a mass food poisoning that was caused by ingestion of rice oil contaminated with dioxins and related organochlorines in 1968. Patients with Yusho suffer from skin symptoms (acneform eruptions, liability to suppuration and pigmentation), respiratory symptoms (cough and expectoration of sputum), neurological symptoms (numbness and paresthesia of extremities), arthralgia and general fatigue, and no effective treatment has yet been developed. In this clinical trial, four Kampo formulae (Bakumondo-to, Keigai-rengyo-to, Gosha-jinki-gan and Hochu-ekki-to) were administered to four representative Yusho symptoms (respiratory, skin, neurological symptoms and general fatigue), respectively. Twenty-seven Yusho patients were enrolled and two formulae were administered to each patient for half-a-year each. The effectiveness of Kampo formulae was estimated by changes in the intensity of symptoms measured by a visual analogue scale (VAS) of 100 mm recorded at baseline and after administration of each formula. The influence of Kampo formulae on patients' quality of life (QOL) was also assessed by the SF-36 (NBS). Twenty-five patients completed the treatment. Bakumondo-to significantly improved respiratory symptoms as well as patients' QOL in the context of vitality, compared with other formulae. In contrast, Hochu-ekki-to impaired patients' QOL in the context of physical functioning and vitality, compared with other formulae. This study demonstrated for the first time that a Kampo formula Bakumondo-to is useful for treating respiratory symptoms caused by dioxins. PMID:19996156

Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study.

PubMed

Terasawa, K; Shimada, Y; Kita, T; Yamamoto, T; Tosa, H; Tanaka, N; Saito, Y; Kanaki, E; Goto, S; Mizushima, N; Fujioka, M; Takase, S; Seki, H; Kimura, I; Ogawa, T; Nakamura, S; Araki, G; Maruyama, I; Maruyama, Y; Takaori, S

1997-03-01

In an earlier placebo-controlled study, we demonstrated that a kampo (Japanese herbal) medicine called Choto-san (Diao-Teng-San in Chinese) was effective in treating vascular dementia. To evaluate its efficacy using more objective criteria, we carried out a multi-center, double-blind study of Choto-san extract (7.5 g/day) and a placebo, each given three times a day for 12 weeks to patients suffering from this condition. The study enrolled and analyzed 139 patients, 50 males and 89 females, with a mean age of 76.6 years. Choto-san was statistically superior to the placebo in global improvement rating, utility rating, global improvement rating of subjective symptoms, global improvement rating of psychiatric symptoms and global improvement rating of disturbance in daily living activities. Such items as spontaneity of conversation, lack of facial expression, decline in simple mathematical ability, global intellectual ability, nocturnal delirium, sleep disturbance, hallucination or delusion, and putting on and taking off clothes were significantly improved at one or more evaluation points in those taking Choto-san compared to those taking the placebo. Furthermore, the change in revised version of Hasegawa's dementia scale from the beginning point in Choto-san group was tended to be higher than that in placebo group with no statistical significance. These results suggest that Choto-san is effective in the treatment of vascular dementia. Copyright © 1997 Gustav Fischer Verlag. Published by Elsevier GmbH.. All rights reserved.

The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study.

PubMed

Nishi, Masaki; Shimada, Mitsuo; Uchiyama, Hideaki; Ikegami, Toru; Arakawa, Yusuke; Hanaoka, Jun; Kanemura, Hirofumi; Morine, Yuji; Imura, Satoru; Miyake, Hidenori; Utsunomiya, Toru

2012-10-01

After hepatic resection, delayed flatus and impaired bowel movement often cause problematic postoperative ileus. Kampo medicine, Dai-kenchu-to (DKT), is reported to have a various beneficial effects on bowel systems. The aim of this study was to prospectively evaluate effects of DKT after hepatic resection. Thirty-two patients who underwent hepatic resection between July 2007 and August 2008 in Tokushima University Hospital were prospectively divided into DKT group (n=16) and control group (n=16). In DKT group, 2.5 g of DKT was administered orally three times a day from postoperative day (POD) 1. Blood was examined on POD 1, 3, 5 and 7. Postoperative first flatus, bowel movement and full recovery of oral intake, hospital stays and complications were checked. In DKT group, levels of c-reactive protein and beta-(1-3)-D-glucan on POD 3 were significantly decreased (p<0.05). Moreover, postoperative periods for the first flatus, bowel movement and the full recovery of oral intake were significantly shortened in DKT group (p<0.05). DKT suppressed inflammatory reaction, stimulated bowel movement and improved oral intake after hepatic resection, which may decrease serious morbidity after hepatic resection.

Establishment of Application Guidance for OTC non-Kampo Crude Drug Extract Products in Japan

PubMed Central

Somekawa, Layla; Maegawa, Hikoichiro; Tsukada, Shinsuke; Nakamura, Takatoshi

2017-01-01

Currently, there are no standardized regulatory systems for herbal medicinal products worldwide. Communication and sharing of knowledge between different regulatory systems will lead to mutual understanding and might help identify topics which deserve further discussion in the establishment of common standards. Regulatory information on traditional herbal medicinal products in Japan is updated by the establishment of Application Guidance for over-the-counter non-Kampo Crude Drug Extract Products. We would like to report on updated regulatory information on the new Application Guidance. Methods for comparison of Crude Drug Extract formulation and standard decoction and criteria for application and the key points to consider for each criterion are indicated in the guidance. Establishment of the guidance contributes to improvements in public health. We hope that the regulatory information about traditional herbal medicinal products in Japan will be of contribution to tackling the challenging task of regulating traditional herbal products worldwide. PMID:28894633

[Scientific Evaluation of Crude Drugs and Kampo Medicines Using the Eastern Blotting Method and Its Application to Biological Metabolic Studies].

PubMed

Morinaga, Osamu

2018-01-01

　The scientific evaluation of crude drugs and kampo medicines (KMs) was demonstrated using the eastern blotting method with monoclonal antibodies (MAbs) against bioactive natural compounds. Scutellariae radix is one of the most important crude drugs used in KMs. Part of its pharmaceutical properties is due to the flavone glycoside baicalin (BI). A quantitative analysis method based on eastern blotting was developed for BI using an anti-BI MAb. A rapid, simple, sensitive, specific analytical system was subsequently established for BI with the eastern blotting technique using dot-blot and chemiluminescent methods. This system was useful as a high-throughput analytical method for the determination of BI in KMs as well as HPLC and enzyme-linked immunosorbent assay systems. Furthermore, an eastern blotting method was applied to the biological metabolic study of glycyrrhizic acid (GL), the major active constituent of licorice, for investigation of metabolites of GL such as 3-monoglucuronyl-glycyrrhetinic acid (3MGA) because licorice causes pseudoaldosteronism as a side effect. This approach may make it possible to determine the pathogenic agents of licorice-induced pseudoaldosteronism.

Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy.

PubMed

Sekiya, Nobuyasu; Shimada, Yutaka; Shintani, Takahiro; Tahara, Eiichi; Kouta, Kazufumi; Shibahara, Naotoshi; Terasawa, Katsutoshi

2005-10-01

The aim of this study was to observe the influence of Kampo therapy on latent chronic fatigue of patients with chronic diseases. One hundred and seventy-three (173) consecutive patients with chronic diseases came to our department for the first time. This was a prospective study. Patients were divided into two groups: a chronic fatigue group (CFG) and a nonchronic fatigue group (NCFG). Based on Kampo diagnosis, both groups were prescribed Kampo formulae as an extract or decoction for 12 weeks. By using questionnaires, patients were assessed concerning their physical and mental types of fatigue, their sleep situation, and their attitude toward work or housekeeping, both before and after 12 weeks of treatment, according to Kampo diagnosis. The mental fatigue, physical fatigue, and sleep scores of both groups, and the work score of CFG, were decreased. The rate of reduction of the fatigue score was significantly greater in CFG than in NCFG. The factor responsible for this difference in fatigue score was physical fatigue. A reduction of the perception of chronic fatigue was observed in patients receiving 12 weeks of Kampo therapy.

Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto.

PubMed

Iwabu, Jun; Watanabe, Junko; Hirakura, Kazuhiro; Ozaki, Yoshinori; Hanazaki, Kazuhiro

2010-11-01

Daikenchuto (DKT), a pharmaceutical-grade traditional Japanese (Kampo) medicine, has been widely used for the treatment of various gastrointestinal disorders including postoperative ileus and has been integrated into the modern medical care system in Japan as a prescription drug. DKT is a multiherbal medicine consisting of Japanese pepper (zanthoxylum fruit), processed ginger, and ginseng with maltose as an additive. Despite substantial research on the pharmacological activities of DKT and its ingredients, the lack of studies on absorption, distribution, metabolism, and excretion of DKT has made it difficult to obtain a consistent picture of its mechanism of action. In the present study, we constructed an analysis procedure consisting of seven conditions of liquid chromatography and mass spectrometric analysis, which enabled the identification of 44 ingredients of DKT component herbs. We investigated the plasma and urine profiles of these ingredients 0.5 to 8 h after oral administration of 15.0 g of DKT in four healthy volunteers. The results indicated that 1) hydroxy-α-sanshool and [6]-shogaol, the prominent peaks in plasma derived from Japanese pepper and ginger, respectively, were detected at 0.5 h and thereafter decreased throughout the sampling period; 2) ginsenoside Rb(1), a prominent peak derived from ginseng, increased gradually during the sampling period; 3) glucuronide conjugates of hydroxy-sanshools, shogaols, and gingerols were detected in plasma and urine; and 4) no obvious differences between samples from the two male and the two female individuals were observed. These results provide a strong basis for future studies on pharmacokinetics and pharmacology of DKT.

The Traditional Medicine and Modern Medicine from Natural Products.

PubMed

Yuan, Haidan; Ma, Qianqian; Ye, Li; Piao, Guangchun

2016-04-29

Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blossomed into orderly-regulated systems of medicine. This study aims to review the literature on the relationship among natural products, traditional medicines, and modern medicine, and to explore the possible concepts and methodologies from natural products and traditional medicines to further develop drug discovery. The unique characteristics of theory, application, current role or status, and modern research of eight kinds of traditional medicine systems are summarized in this study. Although only a tiny fraction of the existing plant species have been scientifically researched for bioactivities since 1805, when the first pharmacologically-active compound morphine was isolated from opium, natural products and traditional medicines have already made fruitful contributions for modern medicine. When used to develop new drugs, natural products and traditional medicines have their incomparable advantages, such as abundant clinical experiences, and their unique diversity of chemical structures and biological activities.

Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice.

PubMed

Ito, Naoki; Hirose, Eiji; Ishida, Tatsuya; Hori, Atsushi; Nagai, Takayuki; Kobayashi, Yoshinori; Kiyohara, Hiroaki; Oikawa, Tetsuro; Hanawa, Toshihiko; Odaguchi, Hiroshi

2017-05-03

Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are lacking. Recently, it has been recognized that stress triggers neuroinflammation and suppresses adult neurogenesis, leading to depression and anxiety. Here, we examined whether kososan extract affected social behavior in mice exposed to chronic social defeat stress (CSDS), an animal model of prolonged psychosocial stress, and neuroinflammation induced by CSDS. In the CSDS paradigm, C57BL/6J mice were exposed to 10 min of social defeat stress from an aggressive CD-1 mouse for 10 consecutive days (days 1-10). Kososan extract (1.0 g/kg) was administered orally once daily for 12 days (days 1-12). On day 11, the social avoidance test was performed to examine depressive- and anxious-like behaviors. To characterize the impacts of kososan on neuroinflammation and adult neurogenesis, immunochemical analyses and ex vivo microglial stimulation assay with lipopolysaccharide (LPS) were performed on days 13-15. Oral administration of kososan extract alleviated social avoidance, depression- and anxiety-like behaviors, caused by CSDS exposure. CSDS exposure resulted in neuroinflammation, as indicated by the increased accumulation of microglia, the resident immune cells of the brain, and their activation in the hippocampus, which was reversed to normal levels by treatment with kososan extract. Additionally, in ex vivo studies, CSDS exposure potentiated the microglial pro-inflammatory response to a subsequent LPS challenge, an effect that was also blunted by kososan extract treatment. Indeed, the modulatory effect of kososan extract on neuroinflammation appears to be due to a hippocampal increase in an anti-inflammatory phenotype of microglia while sparing an increased pro-inflammatory phenotype of microglia caused by CSDS. Moreover, reduced adult hippocampal neurogenesis in

The efficacy of the Kampo medicine rikkunshito for chemotherapy-induced anorexia (RICH trial): study protocol for a randomized controlled trial.

PubMed

Inoue, Takuya; Takagi, Hironori; Owada, Yuki; Watanabe, Yuzuru; Yamaura, Takumi; Fukuhara, Mitsuro; Muto, Satoshi; Okabe, Naoyuki; Matsumura, Yuki; Hasegawa, Takeo; Osugi, Jun; Hoshino, Mika; Higuchi, Mitsunori; Shio, Yutaka; Yokouchi, Hiroshi; Kanazawa, Kenya; Ohbuchi, Katsuya; Fukushima, Takahisa; Munakata, Mitsuru; Suzuki, Hiroyuki

2017-10-18

Cisplatin is a key drug in lung cancer therapy. However, cisplatin is also well known to induce gastrointestinal disorders, such as chemotherapy-induced nausea and vomiting, anorexia, and weight loss. These symptoms sometimes affect patients' quality of life and make continuation of chemotherapy difficult. Anorexia is a cause of concern for patients with cancer because a persistent loss of appetite progresses to cancer cachexia. Although evidence-based management for chemotherapy has recently been established, there is room for improvement. This placebo-controlled, double-blind, randomized trial will aim to determine the efficacy of the traditional Japanese Kampo medicine rikkunshito (TJ-43) for preventing anorexia caused by cisplatin-including chemotherapy in patients with lung cancer. Patients with lung cancer who plan to receive cisplatin-including chemotherapy will be recruited. Patients who provide written consent will be randomly allocated to receive either TJ-43 (arm A) or placebo (arm B) for one course of chemotherapy (21 or 28 consecutive days). Investigators and patients will be masked to the treatment assignment throughout the trial. The primary endpoint will be evaluated as the change in dietary intake from day 0 (the day before the start of chemotherapy) to day 7 of cisplatin-including chemotherapy. The two arms of the trial will comprise 30 patients each. From November 2014, a total of 60 patients will be recruited, and recruitment for the study is planned to be complete by October 2017. This trial is designed to examine the efficacy of rikkunshito (TJ-43) for reducing anorexia and maintaining food intake caused by cisplatin-including chemotherapy in patients with lung cancer. Japan Pharmaceutical Information Center Clinical Trials Information (JAPIC CTI), trial registration: JAPIC CTI-142747 . Registered on 15 December 2014; the RICH trial.

Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in vitro.

PubMed

Gao, Shengli; Satsu, Hideo; Makino, Toshiaki

2018-03-01

Bofutsushosan (BTS; fang feng tong sheng san in Chinese) is a formula in traditional Japanese Kampo medicine and Chinese medicine comprising eighteen crude drugs, and is used to treat obesity and metabolic syndrome. Fructose is contained in refreshing beverages as high-fructose corn syrup, and is associated with obesity. Fructose is absorbed via glucose transporter 5 (GLUT5) in the intestine. Therefore, the inhibition of GLUT5 is considered to be a target of obesity drugs. We evaluated the inhibitory effects of BTS extract and its constituents on fructose uptake using Chinese hamster ovary K1 cells, i.e., cells stably expressing GLUT5. Boiled water extract of BTS significantly suppressed GLUT5 function in a concentration-dependent manner without cytotoxicities. Among 18 components of BTS, the boiled water extracts of the rhizome of Zingiber officinale, the root and rhizome of Saposhnikovia divaricata, and the root of Platycodon grandiflorum exhibited significant inhibitory effects on fructose uptake with IC 50 values of 314, 119 and 475 µg/ml, respectively. Among the constituents of the rhizome of Z. officinale extract, 6-gingerol significantly inhibited GLUT5 with an IC 50 value of 39 µM, while 6-shogaol exhibited a significant but weak inhibition on GLUT5 at 100 µM. One of the mechanisms of action of BTS may be the inhibition of fructose absorption in the intestine, and one of the active components of BTS is the rhizome of Z. officinale and 6-gingerol.

Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model.

PubMed

Inoue, Ken; Naito, Yuji; Takagi, Tomohisa; Hayashi, Natsuko; Hirai, Yasuko; Mizushima, Katsura; Horie, Ryusuke; Fukumoto, Kohei; Yamada, Shinya; Harusato, Akihito; Hirata, Ikuhiro; Omatsu, Tatsushi; Yoshida, Naohisa; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Handa, Osamu; Konishi, Hideyuki; Wakabayashi, Naoki; Yagi, Nobuaki; Ichikawa, Hiroshi; Kokura, Satoshi; Yoshikawa, Toshikazu

2011-01-01

Heat shock protein (HSP) 47 may play an important role in the pathogenesis of intestinal fibrosis. Daikenchuto (DKT), a traditional Japanese herbal (Kampo) medicine, has been reported to ameliorate intestinal inflammation. The aims of this study were to determine time-course profiles of several parameters of fibrosis in a rat model, to confirm the HSP47-expressing cells in the colon, and finally to evaluate DKT's effects on intestinal fibrosis. Colitis was induced in male Wistar rats weighing 200 g using an enema of trinitrobenzene sulfonic acid (TNBS). HSP47 localization was determined by immunohistochemistry. Colonic inflammation and fibrosis were assessed by macroscopic, histological, morphometric, and immunohistochemical analyses. Colonic mRNA expression of transforming growth factor β1 (TGF-β1), HSP47, and collagen type I were assessed by real time-polymerase chain reaction (PCR). DKT was administered orally once a day from 8 to 14 d after TNBS administration. The colon was removed on the 15th day. HSP47 immunoreactivity was coexpressed with α-smooth muscle actin-positive cells located in the subepithelial space. Intracolonic administration of TNBS resulted in grossly visible ulcers. Colonic inflammation persisted for 6 weeks, and fibrosis persisted for 4 weeks after cessation of TNBS treatment. The expression levels of mRNA and proteins for TGF-β1, HSP47, and collagen I were elevated in colonic mucosa treated with TNBS. These fibrosis markers indicated that DKT treatment significantly inhibited TNBS-induced fibrosis. These findings suggest that DKT reduces intestinal fibrosis associated with decreasing expression of HSP47 and collagen content in the intestine.

Medicinal use of wild fauna by mestizo communities living near San Guillermo Biosphere Reserve (San Juan, Argentina).

PubMed

Hernandez, Jorge; Campos, Claudia M; Borghi, Carlos E

2015-01-21

Wild and domestic animals and their by-products are important ingredients in the preparation of curative, protective and preventive medicines. Despite the medicinal use of animals worldwide, this topic has received less attention than the use of medicinal plants. This study assessed the medicinal use of animals by mestizo communities living near San Guillermo MaB Reserve by addressing the following questions: What animal species and body parts are used? What ailments or diseases are treated with remedies from these species? To what extent do mestizo people use animals as a source of medicine? Is the use related to people's age? We conducted semi-structured interviews with 171 inhabitants (15-93 years old) of four villages close to the Reserve: Tudcúm, Angualasto, Malimán and Colangüil. We calculated the informant consensus factor and fidelity level to test homogeneity of knowledge and to know the importance of different medicinal uses for a given species. The medicinal use of animals was reported by 57% of the surveyed people. Seven species were mentioned: Rhea pennata, Lama guanicoe, Puma concolor, Pseudalopex sp., Lama vicugna, Lepus europaeus and Conepatus chinga. Several body parts were used: fat, leg, bezoar-stone, stomach, feather, meat, blood, feces, wool, and liver. The fat of R. pennata was the most frequently used animal part, followed by the bezoar stone and the leg of L. guanicoe. Animals were used to treat 22 ailments, with respiratory and nervous system disorders being the most frequently treated diseases with a high degree of consensus. Old people used animals as remedies more frequently than young residents, showing some differences among villages. A low number of animal species was mentioned as used for medicinal purposes, which could be explained by the perception of strong control related the legislation that bans hunting and the erosion of traditional knowledge produced by mestizaje. However, the presence of a traditional medicine is deeply

The Case of the Suzhou Hospital of National Medicine (1939-41): War, Medicine, and Eastern Civilization.

PubMed

Daidoji, Keiko; Karchmer, Eric I

2017-06-01

This article explores the founding of the Suzhou Hospital of National Medicine in 1939 during the Japanese occupation of Suzhou. We argue that the hospital was the culmination of a period of rich intellectual exchange between traditional Chinese and Japanese physicians in the early twentieth century and provides important insights into the modern development of medicine in both countries. The founding of this hospital was followed closely by leading Japanese Kampo physicians. As the Japanese empire expanded into East Asia, they hoped that they could revitalize their profession at home by disseminating their unique interpretations of the famous Treatise on Cold Damage abroad. The Chinese doctors that founded the Suzhou Hospital of National Medicine were close readers of Japanese scholarship on the Treatise and were inspired to experiment with a Japanese approach to diagnosis, based on new interpretations of the concept of "presentation" ( shō / zheng ). Unfortunately, the Sino-Japanese War cut short this fascinating dialogue on reforming medicine and set the traditional medicine professions in both countries on new nationalist trajectories.

Finding an appropriate equation to measure similarity between binary vectors: case studies on Indonesian and Japanese herbal medicines.

PubMed

Wijaya, Sony Hartono; Afendi, Farit Mochamad; Batubara, Irmanida; Darusman, Latifah K; Altaf-Ul-Amin, Md; Kanaya, Shigehiko

2016-12-07

The binary similarity and dissimilarity measures have critical roles in the processing of data consisting of binary vectors in various fields including bioinformatics and chemometrics. These metrics express the similarity and dissimilarity values between two binary vectors in terms of the positive matches, absence mismatches or negative matches. To our knowledge, there is no published work presenting a systematic way of finding an appropriate equation to measure binary similarity that performs well for certain data type or application. A proper method to select a suitable binary similarity or dissimilarity measure is needed to obtain better classification results. In this study, we proposed a novel approach to select binary similarity and dissimilarity measures. We collected 79 binary similarity and dissimilarity equations by extensive literature search and implemented those equations as an R package called bmeasures. We applied these metrics to quantify the similarity and dissimilarity between herbal medicine formulas belonging to the Indonesian Jamu and Japanese Kampo separately. We assessed the capability of binary equations to classify herbal medicine pairs into match and mismatch efficacies based on their similarity or dissimilarity coefficients using the Receiver Operating Characteristic (ROC) curve analysis. According to the area under the ROC curve results, we found Indonesian Jamu and Japanese Kampo datasets obtained different ranking of binary similarity and dissimilarity measures. Out of all the equations, the Forbes-2 similarity and the Variant of Correlation similarity measures are recommended for studying the relationship between Jamu formulas and Kampo formulas, respectively. The selection of binary similarity and dissimilarity measures for multivariate analysis is data dependent. The proposed method can be used to find the most suitable binary similarity and dissimilarity equation wisely for a particular data. Our finding suggests that all four

The Case of the Suzhou Hospital of National Medicine (1939–41): War, Medicine, and Eastern Civilization

PubMed Central

Daidoji, Keiko; Karchmer, Eric I.

2017-01-01

This article explores the founding of the Suzhou Hospital of National Medicine in 1939 during the Japanese occupation of Suzhou. We argue that the hospital was the culmination of a period of rich intellectual exchange between traditional Chinese and Japanese physicians in the early twentieth century and provides important insights into the modern development of medicine in both countries. The founding of this hospital was followed closely by leading Japanese Kampo physicians. As the Japanese empire expanded into East Asia, they hoped that they could revitalize their profession at home by disseminating their unique interpretations of the famous Treatise on Cold Damage 傷寒論 abroad. The Chinese doctors that founded the Suzhou Hospital of National Medicine were close readers of Japanese scholarship on the Treatise and were inspired to experiment with a Japanese approach to diagnosis, based on new interpretations of the concept of “presentation” (shō / zheng 證). Unfortunately, the Sino-Japanese War cut short this fascinating dialogue on reforming medicine and set the traditional medicine professions in both countries on new nationalist trajectories. PMID:29104703

The Daiokanzoto (TJ-84) Kampo Formulation Reduces Virulence Factor Gene Expression in Porphyromonas gingivalis and Possesses Anti-Inflammatory and Anti-Protease Activities

PubMed Central

Fournier-Larente, Jade; Azelmat, Jabrane; Yoshioka, Masami; Hinode, Daisuke; Grenier, Daniel

2016-01-01

Kampo formulations used in Japan to treat a wide variety of diseases and to promote health are composed of mixtures of crude extracts from the roots, bark, leaves, and rhizomes of a number of herbs. The present study was aimed at identifying the beneficial biological properties of Daiokanzoto (TJ-84), a Kampo formulation composed of crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, with a view to using it as a potential treatment for periodontal disease. Daiokanzoto dose-dependently inhibited the expression of major Porphyromonas gingivalis virulence factors involved in host colonization and tissue destruction. More specifically, Daiokanzoto reduced the expression of the fimA, hagA, rgpA, and rgpB genes, as determined by quantitative real-time PCR. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to evaluate the anti-inflammatory properties of Daiokanzoto. Daiokanzoto attenuated the P. gingivalis-mediated activation of the NF-κB signaling pathway. It also reduced the secretion of pro-inflammatory cytokines (IL-6 and CXCL8) by lipopolysaccharide-stimulated oral epithelial cells and gingival fibroblasts. Lastly, Daiokanzoto, dose-dependently inhibited the catalytic activity of matrix metalloproteinases (-1 and -9). In conclusion, the present study provided evidence that Daiokanzoto shows potential for treating and/or preventing periodontal disease. The ability of this Kampo formulation to act on both bacterial pathogens and the host inflammatory response, the two etiological components of periodontal disease, is of high therapeutic interest. PMID:26859747

The Daiokanzoto (TJ-84) Kampo Formulation Reduces Virulence Factor Gene Expression in Porphyromonas gingivalis and Possesses Anti-Inflammatory and Anti-Protease Activities.

PubMed

Fournier-Larente, Jade; Azelmat, Jabrane; Yoshioka, Masami; Hinode, Daisuke; Grenier, Daniel

2016-01-01

Kampo formulations used in Japan to treat a wide variety of diseases and to promote health are composed of mixtures of crude extracts from the roots, bark, leaves, and rhizomes of a number of herbs. The present study was aimed at identifying the beneficial biological properties of Daiokanzoto (TJ-84), a Kampo formulation composed of crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, with a view to using it as a potential treatment for periodontal disease. Daiokanzoto dose-dependently inhibited the expression of major Porphyromonas gingivalis virulence factors involved in host colonization and tissue destruction. More specifically, Daiokanzoto reduced the expression of the fimA, hagA, rgpA, and rgpB genes, as determined by quantitative real-time PCR. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to evaluate the anti-inflammatory properties of Daiokanzoto. Daiokanzoto attenuated the P. gingivalis-mediated activation of the NF-κB signaling pathway. It also reduced the secretion of pro-inflammatory cytokines (IL-6 and CXCL8) by lipopolysaccharide-stimulated oral epithelial cells and gingival fibroblasts. Lastly, Daiokanzoto, dose-dependently inhibited the catalytic activity of matrix metalloproteinases (-1 and -9). In conclusion, the present study provided evidence that Daiokanzoto shows potential for treating and/or preventing periodontal disease. The ability of this Kampo formulation to act on both bacterial pathogens and the host inflammatory response, the two etiological components of periodontal disease, is of high therapeutic interest.

Acute toxicity and genotoxicity of fermented traditional medicine oyaksungi-san.

PubMed

Park, Hwayong; Hwang, Youn-Hwan; Ma, Jin Yeul

2017-06-01

The traditional medicine oyaksungi-san (OY) has been prescribed in East Asia for hundreds of years for the treatment of stroke, paralysis, and ataxia. OY also has therapeutic effects on arthralgia, myalgia, and rheumatoid arthritis, and recent studies have shown its protective effects against apoptosis of hippocampal cells and its anti-inflammatory effects on the peripheral blood cells of patient with cerebral infarction. Many studies have explored the use of traditional medicine and herb materials in the development of safe, novel, and effective pharmaceuticals with fewer side effects. These efforts commonly adopt a bioconversion tool for fermentation with beneficial microbes. However, only pharmaceuticals with high levels of safety and low levels of toxicity can be used in healthcare system. OY water extract was fermented with Lactobacillus and assayed for acute toxicity and genotoxicity. Single dose acute toxicity, bacterial reverse mutation, chromosome aberrations, and micronucleus were observed and assayed in rats, histidine/tryptophan auxotrophic bacteria, Chinese hamster ovary fibroblast cells, and mice bone marrow cells, respectively. All the experimental animals showed no abnormal behavior, clinical signs, body weight increases, or mortality. In the bacterial cultures, no revertant colonies were observed. Morphological and numerical chromosomal aberrations were not found in all metaphases examined. Frequency of induced micronuclei was not significantly increased in all doses applied. As a whole, no acute toxicity or genotoxicity were observed in all the assays examined. Therefore, fermented OY is considered to be a safe material that can be used for development of complementary and alternative medicine using bioconversion.

Ethnobotany of Indigenous Saraguros: Medicinal Plants Used by Community Healers "Hampiyachakkuna" in the San Lucas Parish, Southern Ecuador.

PubMed

Andrade, José M; Lucero Mosquera, Hernán; Armijos, Chabaco

2017-01-01

This paper reports the results of an ethnobotanical survey on the use of medicinal plants by community healers "Hampiyachakkuna" in the San Lucas Parish, province of Loja, Ecuador. A particular ethnic group, the indigenous Saraguros, inhabits this region. This study reports 183 plant species used in 75 different curative therapies by the Saraguro healers.

Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo.

PubMed

Doo, Ah-Reum; Kim, Seung-Nam; Park, Ji-Yeon; Cho, Ki Ho; Hong, Jongki; Eun-Kyung, Kim; Moon, Sang Kwan; Jung, Woo Sang; Lee, Hyejung; Jung, Jae Han; Park, Hi-Joon

2010-09-15

A traditional herb, Yi-Gan San, has been widely used for the management of neurodegenerative disorders in traditional East Asian Medicine. The present study investigated the neuroprotective effects of Yi-Gan San in 1-methyl-4-phenylpyridine/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cytotoxicity in vitro and in vivo and sought to clarify its underlying mechanisms. The effect of Yi-Gan San on 1-methyl-4-phenylpyridine was measured in terms of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assays, caspase-3 activity, and western blot analysis of phosphorylated Akt, one of the survival-related signaling proteins in SH-SY5Y cells. The effects of Yi-Gan San were also confirmed in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian mouse model using a rotarod test and tyrosine hydroxylase-immunohistochemistry. Pretreatment of Yi-Gan San with 1-methyl-4-phenylpyridine showed a significant protective effect on SH-SY5Y cells and significantly decreased the level of caspase-3 activity compared to the values for the 1-methyl-4-phenylpyridine-treated cells. This process increased the protein expressions of phosphorylated Akt, and an inhibitor of phosphatidylinositol 3-kinase (PI3K)/Akt, LY294002, significantly decreased this protective effect of Yi-Gan San. In the mouse Parkinson's disease model, treatment with Yi-Gan San also significantly improved motor functioning and prevented dopaminergic loss related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine challenge. Using both in vitro and in vivo methods, this study revealed that Yi-Gan San has neuroprotective effects and rescues dopaminergic neurons from 1-methyl-4-phenylpyridine/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity, possibly via the PI3K/Akt pathway. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Air Force Personalized Medicine Program Panel: Representative Research at the 59th Medical Wing San Antonio Military Medical Center

DTIC Science & Technology

2016-05-18

and treatment strategies at the San Antonio Military Health System. Panel members will describe studies in Disease Management providing evidence for...Application in a Clinical CBA: AFMSand MAJCOM Needs (Research Knowledge) Setti g Optimization of Pharmacologic Cardiovascular Personalized Care...Medicine Research Program Development of Human Mesenchymal Stem Cells for Treatment of Immune System Dysregulation in Neurological & other Diseases

Ethnobotany of Indigenous Saraguros: Medicinal Plants Used by Community Healers “Hampiyachakkuna” in the San Lucas Parish, Southern Ecuador

PubMed Central

Lucero Mosquera, Hernán; Armijos, Chabaco

2017-01-01

This paper reports the results of an ethnobotanical survey on the use of medicinal plants by community healers “Hampiyachakkuna” in the San Lucas Parish, province of Loja, Ecuador. A particular ethnic group, the indigenous Saraguros, inhabits this region. This study reports 183 plant species used in 75 different curative therapies by the Saraguro healers. PMID:28744470

Anxiolytic and neuroprotective effects of the Traditional Chinese Medicinal formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress.

PubMed

Cao, Guo-Ping; Gui, Dan; Fu, Lu-Di; Guo, Zhou-Ke; Fu, Wen-Jun

2016-08-01

Dan-zhi-xiao-yao-san is a Traditional Chinese Medicinal formulation widely used for the treatment of neuropsychological disorders. The present study examined the anxiolytic and neuroprotective effects of Dan-zhi-xiao-yao-san in a rat model of chronic stress. The results of an elevated plus maze test showed that Dan‑zhi‑xiao‑yao‑san significantly attenuated the levels of anxiety-induced stress as evidenced by increases in the time spent in the open arm region, as well as the percentage of entries into this area. In addition, Dan-zhi-xiao-yao-san alleviated stress‑induced neuronal death, as indicated by histological examination. Furthermore, mechanistic studies suggested that the anxiolytic and neuroprotective effects of Dan-zhi-xiao-yao-san may be mediated via attenuation of chronic stress‑induced upregulation of α‑synuclein and corticosterone, and downregulation of protein phosphatase 2A (PP2A) in the hippocampal region of the brain at the mRNA and protein level. In addition, Dan‑zhi‑xiao‑yao‑san decreased the serum levels of stress‑induced corticosterone in the model animals. In conclusion, the present study demonstrated that Dan‑zhi‑xiao‑yao‑san exerted anxiolytic and neuroprotective effects in a rat model of chronic stress via attenuation of stress‑induced upregulation of α‑synuclein and corticosterone, and downregulation of PP2A in the hippocampus.

Analysis and Management of Rectal Gas with Kampo Formulas During Intensity-Modulated Radiotherapy of Prostate Cancer: A Case Series Study.

PubMed

Nagai, Aiko; Shibamoto, Yuta; Ogawa, Keiko; Inoda, Koji; Yoshida, Masanori; Kikuchi, Yuzo

2016-06-01

During intensity-modulated radiation therapy (IMRT) for prostate cancer, the target, bladder, and rectum positions should be kept constant to reduce adverse events, such as radiation proctitis, and to increase local tumor control. For this purpose, decreasing the rectal contents as much as possible is important. Daisaikoto (DST) and bukuryoingohangekobokuto (BIHKT) are traditional Japanese herbal (Kampo) formulas that have been used to treat patients with abdominal bloating or constipation. This study investigated the effect of DST and BIHKT on the rectal gas volume during prostate IMRT according to Kampo diagnosis. Five patients were treated with DST or BIHKT at a dose of 5.0 or 7.5 g/d. The volume of rectal gas in 189 megavoltage computed tomographic images taken before each treatment session and the frequency of rectal gas drainage were evaluated before and after DST or BIHKT administration. After DST or BIHKT treatment, the mean volume of rectal gas was reduced from 6.4 to 2.1 mL, and the mean frequency of gas drainage decreased from 43% to 9%. DST and BIHKT appear to be useful in reducing rectal gas, which would help prevent radiation proctitis and improve the local control of prostate cancer with IMRT.

Folk Medicine

MedlinePlus

... lead’s effects on health. How to tell if herbal medicines or folk medicines contain lead You only can ... as high as 90%. Ghasard, an Indian folk medicine, has also been found to contain lead. It is a brown powder used as a tonic. Ba-baw-san is a Chinese herbal remedy that contains lead. It is used to ...

Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice.

PubMed

Zhao, Qi; Murakami, Yukihisa; Tohda, Michihisa; Obi, Ryosuke; Shimada, Yutaka; Matsumoto, Kinzo

2007-04-01

We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model. In this study, the object discrimination tasks were used to determine if the ameliorative effects of CTS on P2VO-induced cognitive deficits are a characteristic pharmacological profile of this formula, with the aim of clarifying the mechanisms by which CTS enhances central cholinergic function in P2VO mice. The cholinesterase inhibitor tacrine (THA) and Kampo formula saikokeishito (SKT) were used as controls. P2VO impaired object discrimination performance in the object recognition, location, and context tests. Daily administration of CTS (750 mg/kg, p.o.) and THA (2.5 mg/kg, i.p.) improved the object discrimination deficits, whereas SKT (750 mg/kg, p.o.) did not. In ex vivo assays, tacrine but not CTS or SKT inhibited cortical cholinesterase activity. P2VO reduced the mRNA expression of m(3) and m(5) muscarinic receptors and choline acetyltransferase but not that of other muscarinic receptor subtypes in the cerebral cortex. Daily administration of CTS and THA but not SKT reversed these expression changes. These results suggest that CTS and THA improve P2VO-induced cognitive impairment by normalizing the deficit of central cholinergic systems and that the beneficial effect on P2VO-induced cognitive deficits is a distinctive pharmacological characteristic of CTS.

A HPLC-DAD method for the simultaneous determination of five marker components in the traditional herbal medicine Bangpungtongsung-san

PubMed Central

Weon, Jin Bae; Yang, Hye Jin; Ma, Jin Yeul; Ma, Choong Je

2011-01-01

Background: Bangpungtongsung-san, one of the traditional herbal medicines, was known to be a prescription for obesity. Objective: For the simultaneous determination of five components (paeoniflorin, 6-gingerol, decursin, geniposide, and glycyrrhizin) in Bangpungtongsung-san, a high-performance liquid chromatography with diode-array detector method was established. Materials and Methods: To develop the method, a reverse phase column, DIONEX C 18 (5 μm, 120 µ, 4.6 mm × 150 mm) was used. The mobile phase consisted of methanol and water using a gradient elution. The UV wavelength was set at 230, 240, and 254 nm. Method validation was accomplished by linearity, precision test, and recovery test. Results: All calibration curves of components showed good linearity (R 2 > 0.9959). The limit of detection (LOD) and limit of quantification (LOQ) ranged from 0.01 to 0.17 μg/ml and 0.04 to 0.53 μg/ml, respectively. The relative standard deviations (RSD) value of precision test, intraday and interday tests were less than 0.43% and 1.26%. In the recovery test, results of accuracy ranged from 95.27% to 107.70% with RSD values less than 2.21%. Conclusion: This developed method was applied to the commercial Bangpungtongsung-san sample and the five marker components were separated effectively without interference of any peaks of components. PMID:21472081

Paljung-San, a traditional herbal medicine, attenuates benign prostatic hyperplasia in vitro and in vivo.

PubMed

Park, Eunsook; Lee, Mee-Young; Jeon, Woo-Young; Seo, Chang-Seob; You, Sooseong; Shin, Hyeun-Kyoo

2018-05-23

Paljung-san is a traditional herbal medicine used widely for the treatment of urogenital diseases in East Asia. However, scientific evidence of the efficacy of Paljung-san and its mechanisms of action against benign prostatic hyperplasia (BPH) is not clearly established. We investigated the inhibitory effect of Paljung-san water extract (PSWE) and its mechanisms against BPH in vitro and in vivo. Active compounds of PSWE were analyzed quantitatively by High-performance liquid chromatography (HPLC). For in vitro study, PSWE treated BPH-1 cells were used to perform western blot analysis, cell cycle analysis and enzyme-linked immunosorbent assay. For in vivo BPH model, male rats were subcutaneously injected with 10 mg/kg of testosterone propionate (TP) every day for four weeks. 200 and 500 mg/kg of PSWE was administrated daily by oral gavage with s.c. injection of TP, respectively. HPLC revealed that PSWE contains 1.21, 1.18, 2.27, 3.56, 4.23, 3.00, 6.78, and 0.004 mg/g of gallic acid, 5-caffeoylquinic acid, chlorogenic acid, geniposide, liquiritin apioside, liquiritin, glycyrrhizin, and chrysophanol components, respectively. In human BPH-1 cells, PSWE treatment reduced cell proliferation through arresting the cell cycle in the DNA synthesis phase. Moreover, PSWE suppressed prostaglandin E 2 production with reduced cyclooxygenase-2 expression. In TP -induced BPH rat model, PSWE administration showed reduced prostate weights and dihydrotestosterone levels and led to a restoration of normal prostate morphology. PSWE also decreased TP-induced Ki-67 and cyclin D1 protein levels in the prostatic tissues. Decreased glutathione reductase activity and increased malondialdehyde levels in the BPH groups were reversed by PSWE administration. PSWE attenuates the progression of BPH through anti-proliferative, anti-inflammatory and anti-oxidant activities in vitro and in vivo. Therefore, these data provide the scientific evidence of pharmacological efficacy of PSWE against BPH

Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model

PubMed Central

Sawada, Yumi; Hashimoto, Hirofumi; Yoshimura, Mitsuhiro; Ohbuchi, Katsuya; Sudo, Yuka; Suzuki, Masami; Miyano, Kanako; Shiraishi, Seiji; Higami, Yoshikazu; Yanagihara, Kazuyoshi; Hattori, Tomohisa; Kase, Yoshio; Ueta, Yoichi; Uezono, Yasuhito

2017-01-01

Cancer cachexia (CC) is a multifactorial disease characterized by decreased food intake and loss of body weight due to reduced musculature with or without loss of fat mass. Patients with gastric cancer have a high incidence of cachexia. We previously established a novel CC rat model induced by human gastric cancer-derived 85As2 cells in order to examine the pathophysiology of CC and identify potential therapeutics. In patients with CC, anorexia is often observed, despite elevation of ghrelin, suggesting that ghrelin resistance may develop in these patients. In this study, we aimed to clarify the occurrence of ghrelin resistance in CC rats accompanied by anorexia and we investigated whether rikkunshito (RKT), a traditional Japanese Kampo medicine that potentiates ghrelin signaling, ameliorated CC-related anorexia through alleviation of ghrelin resistance. 85As2-tumor-bearing rats developed severe CC symptoms, including anorexia and loss of body weight/musculature, with the latter symptoms being greater in cachectic rats than in non-tumor-bearing or pair-fed rats. CC rats showed poor responses to intraperitoneal injection of ghrelin. In CC rats, plasma ghrelin levels were elevated and hypothalamic anorexigenic peptide mRNA levels were decreased, whereas hypothalamic growth hormone secretagogue receptor (GHS-R) mRNA was not affected. In vitro, RKT directly enhanced ghrelin-induced GHS-R activation. RKT administrated orally for 7 days partly alleviated the poor response to ghrelin and ameliorated anorexia without affecting the elevation of plasma ghrelin levels in CC rats. The expression of hypothalamic orexigenic neuropeptide Y mRNA but not hypothalamic GHS-R mRNA was increased by RKT. Thus, the 85As2 cell-induced CC rat model developed ghrelin resistance, possibly contributing to anorexia and body weight loss. The mechanism through which RKT ameliorated anorexia in the CC rat model may involve alleviation of ghrelin resistance by enhancement of ghrelin signaling

Arizona TeleMedicine Network: Segment Specifications--Tuba City via Mt. Elden, Phoenix; Keams Canyon, Second Mesa, Low Mountain; Phoenix, San Carlos, Bylas; Keams Canyon via Ganado Mesa, Ft. Defiance; Tuba City via Black Mesa, Ft. Defiance; and Budgetary Cost Information--Pinal Peak via San Xavier, Tucson.

ERIC Educational Resources Information Center

Atlantic Research Corp., Alexandria, VA.

The communication links of five different segments of the Arizona TeleMedicine Network (a telecommunication system designed to provide health services for American Indians in rurally isolated areas) and budgetary cost information for Pinal Peak via San Xavier and Tucson are described in this document. The five communication links are identified…

The use of herbal medicine in cancer-related anorexia/ cachexia treatment around the world.

PubMed

Cheng, Kai-Chun; Li, Ying-Xiao; Cheng, Juei-Tang

2012-01-01

Cancer-related cachexia, a condition in which the body is consumed by deranged carbohydrate, lipid and protein metabolism that is induced by inflammatory cytokines. Cachexia is associated with poor treatment outcome, fatigue and poor quality of life. Pharmacological intervention in the treatment and/or prevention of cachexia has been mainly aimed at the use of appetite enhancers to increase oral nutritional intake so far. Herbal remedies are part of traditional and folk healing methods with long histories of use. In this report, we have assessed which herbal approaches have had associated cancer cachexia case reports. Commonly used herbal medicines in western countries include essiac, iscador, pau d'arco tea, cannabinoids and so on. Some Kampo herbs and formulations are commonly used by cancer patients reduce the side effects and complications during the antitumor therapy. The relevant herbal medicines include ginseng, C. rhizome and radix astragali, and the related herbal remedies, such as TJ-48, TJ-41, PHY906 and Rikkunshito. However, there still have some adverse effects caused or amplified by herb and drug interactions that are difficult to separate. However, randomized effectiveness of herbal medicines shall be further identified in controlled clinical trials involving cancer patients with cachexia.

This plant treats that illness? The hot-cold system and therapeutic procedures mediate medicinal plant use in San Miguel Tulancingo, Oaxaca, Mexico.

PubMed

García-Hernández, Karina Yaredi; Vibrans, Heike; Rivas-Guevara, María; Aguilar-Contreras, Abigail

2015-04-02

Understanding the reasoning behind the choice of medicinal plants is relevant for both pharmacological and ethnobotanical quantitative studies. In this study, we analyze how the traditional medical system influences the choice of medicinal plants in a Mexican indigenous population. The study area was San Miguel Tulancingo, Oaxaca, Mexico, and the studied people the Rru ngigua (or Chocholtecs), an Otomangue group with only a few hundred speakers remaining. Through in-depth and repeated interviews of four traditional healers and ethnobotanical collections, we identified, described and classified the medicinal plants, the nosological units, the therapeutic procedures and the reasoning behind medicinal plant and treatment choice. The hot-cold system, which considers illness to be a result of humoral imbalance, strongly influences treatment choice. "Hot" plants are used mainly to treat "cold" diseases, and vice versa. With some variation, plants are selected mainly for this hot-or-cold property, and the specific plant species is often not very relevant. In addition, many plants are associated with specific healing procedures, such as sweat baths. The procedures, in turn, may be used to treat various diseases. The study shows that the relationship between medicinal plants and treated diseases is complex and indirect in most cases. It is strongly influenced by the hot-cold concept and by therapeutic procedures. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Consultation clinics for complementary and alternative medicine at Japanese university hospitals: An analysis at Tokushima University Hospital

PubMed Central

YANAGAWA, HIROAKI; TERAO, JUNJI; TAKEDA, EIJI; TAKAISHI, YOSHIHISA; KASHIWADA, YOSHIKI; KAWAZOE, KAZUYOSHI; FUSHITANI, SHUJI; TSUCHIYA, KOICHIRO; YAMAUCHI, AIKO; SATO, CHIHO; IRAHARA, MINORU

2010-01-01

Here, we report on a Consultation Clinic for Complementary and Alternative Medicine (CAM) which we established at Tokushima University Hospital in July of 2007 with the aim of providing person-to-person information on CAM, though not CAM therapy itself. In December of 2008, we received 55 applications for consultation, 37% concerning health foods, 37% Japanese herbal medicine (Kampo), and 26% various other topics. The consultants (nutritionists and pharmacists) communicated individually with 38 applicants; malignancies (26%) and cardiovascular disease (24%) were the main underlying concerns. To promote the quality of consultation, data was collected by means of focus group interviews concerning the perspective of the consultants. Safe and effective use of CAM requires a network of communication linking individuals, consultation teams, physicians, primary care institutions and university hospitals. To advance this goal, we plan to broaden the efforts described herein. Our findings indicate that the specific role of the consultation clinic in promoting the scientific use of CAM merits further study. PMID:22993564

Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials.

PubMed

Sun, Yan; Xu, Xia; Zhang, Jinping; Chen, Yuanyuan

2018-02-17

Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017. In this review, wehave included randomized control trials that compared Chai Hu Shu Gan San (or its combination with a regular Western medicine) with a regular Western medicine alone for the treatment of depression. Two investigators independently extracted and analyzed the data using RevMan 5.2.0 software. Mean difference (with a 95% confidence interval) was used as efficacy indices for outcomes. We included 42 studies involving 3234 patients with depression in 15 different types of diseases. Meta analyses showed better effect of Chai Hu Shu Gan San than fluoxetine for pure depression (MD = - 1.59, from - 2.82 to - 0.37, 4 trials, I 2  = 26%), for post-stroke depression (MD = - 4.20, from - 6.20 to - 2.19, 7 trials, I 2  = 96%), and for postpartum depression (MD = - 4.10, from - 7.48 to - 0.72 7 trials, I 2  = 86%). None of the articles reported severe adverse events of oral administration of Chai Hu Shu Gan San. Furthermore, any adverse effects of using Chai Hu Shu Gan San alone were fewer than those of regular Western medicines. This review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. A meticulously designed and conducted randomized control trial is needed for further evaluation.

78 FR 53243 - Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2013-0555] RIN 1625-AA00 Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA AGENCY: Coast Guard, DHS. ACTION...-591 Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA. (a) Location. The limits of the...

Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: results from a large-scale nationwide survey.

PubMed

Shimizu, Seiji; Kobayashi, Taku; Tomioka, Hideo; Ohtsu, Kensei; Matsui, Toshiyuki; Hibi, Toshifumi

2017-03-01

Mesenteric phlebosclerosis (MP) is a rare disease characterized by venous calcification extending from the colonic wall to the mesentery, with chronic ischemic changes from venous return impairment in the intestine. It is an idiopathic disease, but increasing attention has been paid to the potential involvement of herbal medicine, or Kampo, in its etiology. Until now, there were scattered case reports, but no large-scale studies have been conducted to unravel the clinical characteristics and etiology of the disease. A nationwide survey was conducted using questionnaires to assess possible etiology (particularly the involvement of herbal medicine), clinical manifestations, disease course, and treatment of MP. Data from 222 patients were collected. Among the 169 patients (76.1 %), whose history of herbal medicine was obtained, 147 (87.0 %) used herbal medicines. The use of herbal medicines containing sanshishi (gardenia fruit, Gardenia jasminoides Ellis) was reported in 119 out of 147 patients (81.0 %). Therefore, the use of herbal medicine containing sanshishi was confirmed in 70.4 % of 169 patients whose history of herbal medicine was obtained. The duration of sanshishi use ranged from 3 to 51 years (mean 13.6 years). Patients who discontinued sanshishi showed a better outcome compared with those who continued it. The use of herbal medicine containing sanshishi is associated with the etiology of MP. Although it may not be the causative factor, it is necessary for gastroenterologists to be aware of the potential risk of herbal medicine containing sanshishi for the development of MP.

77 FR 54811 - Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... 1625-AA00 Safety Zone; TriRock San Diego, San Diego Bay, San Diego, CA AGENCY: Coast Guard, DHS. ACTION... sponsoring the TriRock Triathlon, consisting of 2000 swimmers swimming a predetermined course. The sponsor... to read as follows: Sec. 165.T11-516 Safety Zone; TriRock Triathlon; San Diego Bay, San Diego, CA. (a...

The influence of the sennosides on absorption of glycyrrhetic acid in rats.

PubMed

Mizuhara, Yasuharu; Takizawa, Yukiho; Ishihara, Kazuhisa; Asano, Takayuki; Kushida, Hirotaka; Morota, Takashi; Kase, Yoshio; Takeda, Shuichi; Aburada, Masaki; Nomura, Masaaki; Yokogawa, Koichi

2005-10-01

In the course of our clinical studies of Kampo medicine (traditional Japanese medicines), we observed the pharmacokinetic interactions between two herbs. When Onpito (TJ-8117, Kampo medicine) containing licorice and rhubarb was administered orally to human subjects, we observed that the AUC(0-lim) and Cmax of glycyrrhetic acid (GA) in plasma were lower than those treated with other Kampo medicines containing licorice. In this study, we demonstrate the pharmacokinetic interactions of GA derived from glycyrrhizinic acid (GL) in licorice and anthraquinones derived from rhubarb. To our knowledge, this is the first report to investigate the pharmacokinetic interactions between two herbs. When GL was orally co-administrated to rats with a non-effective dose of sennoside A having purgative activity, the AUC(0-lim) and Cmax of GA decreased. In addition, sennoside A did not affect the metabolism of GL by the intestinal bacteria in vitro. In the examination using an in situ loop of rat colon, the remaining ratio of GA rose drastically by the co-administration of sennoside A, sennidin A and rhein. Observed inhibition activity of these anthraquinones on GA absorption depended on the concentration of the components added. The maximum inhibition ratio was approximately 75% by rhein, 60% by sennoside A and 25% by sennidin A. We conclude that the decrease of the pharmacokinetic parameters of GA in human plasma observed in the clinical study of TJ-8117 is attributable to an interactive action of absorption from the intestinal tract by anthraquinones contained in or derived from rhubarb.

Aerospace medicine at Brooks AFB, TX: hail and farewell.

PubMed

Nunneley, Sarah A; Webb, James T

2011-05-01

With the impending termination of USAF operations at Brooks Air Force Base (AFB) in San Antonio, TX, it is time to consider its historic role in Aerospace Medicine. The base was established in 1917 as a flight training center for the U.S. Army Air Service and in 1926 became home to its School of Aviation Medicine. The school moved to San Antonio's Randolph Field in 1931, but in 1959 it returned to Brooks where it occupied new facilities to support its role as a national center for U.S. Air Force aerospace medicine, including teaching, clinical medicine, and research. The mission was then expanded to encompass support of U.S. military and civilian space programs. With the abrupt termination of the military space program in 1969, research at Brooks focused on clinical aviation medicine and support of advanced military aircraft while continuing close cooperation with NASA in support of orbital spaceflight and the journey to the Moon. Reorganization in the 1990s assigned all research functions at Brooks to the Human Systems Division and its successors, leaving to USAFSAM the missions related to clinical work and teaching. In 2002 the USAF and the city of San Antonio implemented shared operation of Brooks as a "City-Base" in the hope of deflecting threatened closure. Nevertheless, under continuing pressure to consolidate military facilities in the United States, the 2005 Base Closure and Realignment Commission ordered Brooks closed by 2011, with its aerospace medicine functions relocated to new facilities at Wright-Patterson AFB in Dayton, OH.

Arizona TeleMedicine Project.

ERIC Educational Resources Information Center

Arizona Univ., Tucson. Coll. of Medicine.

Designed to provide health services for American Indians living on rurally isolated reservations, the Arizona TeleMedicine Project proposes to link Phoenix and Tucson medical centers, via a statewide telecommunications system, with the Hopi, San Carlos Apache, Papago, Navajo, and White Mountain Apache reservations. Advisory boards are being…

San Francisco folio, California, Tamalpais, San Francisco, Concord, San Mateo, and Haywards quadrangles

USGS Publications Warehouse

Lawson, Andrew Cowper

1914-01-01

The five sheets of the San Francisco folio the Tamalpais, Ban Francisco, Concord, Ban Mateo, and Haywards sheets map a territory lying between latitude 37° 30' and 38° and longitude 122° and 122° 45'. Large parts of four of these sheets cover the waters of the Bay of San Francisco or of the adjacent Pacific Ocean. (See fig. 1.) Within the area mapped are the cities of San Francisco, Oakland, Berkeley, Alameda, Ban Rafael, and San Mateo, and many smaller towns and villages. These cities, which have a population aggregating about 750,000, together form the largest and most important center of commercial and industrial activity on the west coast of the United States. The natural advantages afforded by a great harbor, where the railways from the east meet the ships from all ports of the world, have determined the site of a flourishing cosmopolitan, commercial city on the shores of San Francisco Bay. The bay is encircled by hilly and mountainous country diversified by fertile valley lands and divides the territory mapped into two rather contrasted parts, the western part being again divided by the Golden Gate. It will therefore be convenient to sketch the geographic features under four headings (1) the area east of San Francisco Bay; (2) the San Francisco Peninsula; (3) the Marin Peninsula; (4) San Francisco Bay. (See fig. 2.)

Zingiberis Siccatum Rhizoma, the active component of the Kampo formula Daikenchuto, induces anti-inflammatory actions through α7 nicotinic acetylcholine receptor activation.

PubMed

Endo, M; Hori, M; Mihara, T; Ozaki, H; Oikawa, T; Odaguchi, H; Hanawa, T

2017-12-01

We previously reported that Daikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal (Kampo) medicine used for the treatment of postoperative ileus (POI), has characteristic potent anti-inflammatory activity. This effect may be partly mediated by the activation of α7 nicotinic acetylcholine receptor (nAChR). In this study, we identified the specific herbs in DKT that induce anti-inflammatory action. The herbal components of DKT were individually administered orally to each mouse four times before and after intestinal manipulation (IM) was carried out on the distal ileum. The anti-inflammatory activity of each crude drug was subsequently evaluated using immunohistochemical analyses of relevant molecules. Treatment with Zingiberis Siccatum Rhizoma (ZSR) but not the other components inhibited the infiltration of cluster of differentiation 68 (CD68)-positive macrophages as effectively as DKT treatment. Selective α7nAChR antagonists, such as methyllycaconitine citrate, or transient receptor potential ankyrin 1 (TRPA1) antagonists, such as HC-030031, significantly inhibited the amelioration of macrophage infiltration by ZSR. The inhibition of macrophage infiltration by ZSR was abolished in both α7nAChR and 5-hydroxytryptamine 4 receptor (5-HT 4 R) knockout mice. Daikenchuto-induced anti-inflammatory activity, which was mediated by inhibiting macrophage infiltration in POI, is dependent on the effects of ZSR. Zingiberis Siccatum Rhizoma activates TRPA1 channels possibly in enterochromaffin (EC) cells to release 5-HT, which stimulates 5-HT 4 R in the myenteric plexus neurons to release ACh, which in turn activates α7nAChR on macrophages to inhibit inflammation in POI. © 2017 John Wiley & Sons Ltd.

1. Historic American Buildings Survey San Francisco Chronicle Library San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey San Francisco Chronicle Library San Francisco, California PHOTO TAKEN ABOUT 1910 - Yerba Buena Lighthouse Buildings, Yerba Buena Island, San Francisco, San Francisco County, CA

A Chinese herbal medicine, jia-wei-xiao-yao-san, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

PubMed

Chien, Shu-Chen; Chang, Wei-Chiao; Lin, Pu-Hua; Chang, Wei-Pin; Hsu, Shih-Chung; Chang, Jung-Chen; Wu, Ya-Chieh; Pei, Jin-Kuo; Lin, Chia-Hsien

2014-01-01

Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.

Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training.

PubMed

Santhosh, Lekshmi; Babik, Jennifer; Looney, Mark R; Hollander, Harry

2017-04-01

Twenty years ago, the term "hospitalist" was coined at the University of California-San Francisco (San Francisco, CA), heralding a new specialty focused on the care of inpatients. There are now more than 50,000 hospitalists practicing in the United States. At many academic medical centers, hospitalists are largely replacing subspecialists as attendings on the inpatient medicine wards. At University of California-San Francisco, this has been accompanied by declining percentages of residency graduates who enter subspecialty training in internal medicine. The decline in subspecialty medicine interest can be attributed to many factors, including differences in compensation, decreased subspecialist exposure, and a changing research funding landscape. Although there has not been systematic documentation of this trend in pulmonary and critical care medicine, we have noted previously pulmonary and critical care-bound trainees switching to hospital medicine instead. With our broad, multiorgan system perspective, pulmonary and critical care faculty should embrace teaching general medicine. Residency programs have instituted creative solutions to encourage more internal medicine residents to pursue careers in subspecialty medicine. Some solutions include creating rotations that promote more contact with subspecialists and physician-scientists, creating clinician-educator tracks within fellowship programs, and appointing subspecialists to internal medicine residency leadership positions. We need more rigorous research to track the trends and implications of the generalist-specialist balance of inpatient ward teams on resident career choices, and learn what interventions affect those choices.

Medicinal ethnobotany in Huacareta (Chuquisaca, Bolivia).

PubMed

Quiroga, Rodrigo; Meneses, Lidia; Bussmann, Rainer W

2012-08-02

The aim of this study was to document the types of diseases treated by the use of medicinal plants, their main applications and also to have a report of the major diseases treated at the Hospital of San Pablo de Huacareta (Chuquisaca Bolivia). We conducted semi-structured interviews on the use medicinal plants with 10 local informants, and categorized the kinds of diseases treated by traditional medicine. We obtained reports of cases treated at the Hospital of Huacareta in order to compare the use frequency of traditional medicine and allopathic medicine for the treatment of recurrent diseases in the area. Our survey identified 258 traditional medicine uses, spanning a total of 13 diseases categories and including 91 native and exotic plant species and one unidentified sample plant type. Gastrointestinal disorders (55%) were most frequently treated with medicinal plants, followed by afflictions of the musculoskeletal system (25%) and dermatological disorders (24%). Hospital information indicates that the most common diseases are acute respiratory infections (47%) and acute diarrheal diseases (37%). The herbal remedies were mostly used in the form of teas and decoctions. The informants used mainly native plant species, although exotic species has been introduced to the pharmacopoeia. The treatment of gastrointestinal disorders is the primary objective of the medical ethnobotany of the inhabitants of Huacareta, while respiratory system diseases are mostly treated in the hospital. Looking at the data from the Hospital records we can infer that gastrointestinal disorders are among the most common diseases in the study area. For most respondents, traditional medicine is a reliable choice for the care of their illnesses. However, the preference of the population for either traditional medicine or allopathic medicine needs to be clarified in future comparative studies to obtain more convincing results. The results presented can be used as a base for subsequent work

The San Antonio CATs Initiative.

PubMed

Rugh, John D; Hendricson, William D; Hatch, John P; Glass, Birgit J

2010-01-01

There is evidence from medicine that schools and practitioners are slow to adopt new and proven effective treatments while marketing efforts lead practitioners to too quickly adopt unproven modalities. To address these problems, the dental school at the University of Texas Health Sciences Center at San Antonio, has developed a program designed to teach students, faculty, and practitioners the skills of accessing the literature as an intrinsic part of treatment. The Critically Appraised Topics (CATs) program is described and evidence is presented showing that participants can be taught to prepare high-quality summaries of the literature pertinent to clinical problems.

75 FR 38412 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... waters of San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to... San Diego POPS Fireworks, which will include fireworks presentations conducted from a barge in San...

Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain

PubMed Central

2011-01-01

Background Chotosan (CTS, Diaoteng San), a Kampo medicine (ie Chinese medicine) formula, is reportedly effective in the treatment of patients with cerebral ischemic insults. This study aims to evaluate the therapeutic potential of CTS in cognitive deficits and investigates the effects and molecular mechanism(s) of CTS on learning and memory deficits and emotional abnormality in an animal aging model, namely 20-week-old senescence-accelerated prone mice (SAMP8), with and without a transient ischemic insult (T2VO). Methods Age-matched senescence-resistant inbred strain mice (SAMR1) were used as control. SAMP8 received T2VO (T2VO-SAMP8) or sham operation (sham-SAMP8) at day 0. These SAMP8 groups were administered CTS (750 mg/kg, p.o.) or water daily for three weeks from day 3. Results Compared with the control group, both sham-SAMP8 and T2VO-SAMP8 groups exhibited cognitive deficits in the object discrimination and water maze tests and emotional abnormality in the elevated plus maze test. T2VO significantly exacerbated spatial cognitive deficits of SAMP8 elucidated by the water maze test. CTS administration ameliorated the cognitive deficits and emotional abnormality of sham- and T2VO-SAMP8 groups. Western blotting and immunohistochemical studies revealed a marked decrease in the levels of phosphorylated forms of neuroplasticity-related proteins, N-methyl-D-aspartate receptor 1 (NMDAR1), Ca2+/calmodulin-dependent protein kinase II (CaMKII), cyclic AMP responsive element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the frontal cortices of sham-SAMP8 and T2VO-SAMP8. Moreover, these animal groups showed significantly reduced levels of vasculogenesis/angiogenesis factors, vascular endothelial growth factor (VEGF), VEGF receptor type 2 (VEGFR2), platelet-derived growth factor-A (PDGF-A) and PDGF receptor α (PDGFRα). CTS treatment reversed the expression levels of these factors down-regulated in the brains of sham- and T2VO-SAMP8. Conclusion

40. Historic American Buildings Survey San Francisco Chronicle Collection San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Historic American Buildings Survey San Francisco Chronicle Collection San Francisco, California March 24, 1924 VIEW OF HIGH ALTAR - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

29. Photocopy of photograph (from San Francisco Chronicle Library, San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Photocopy of photograph (from San Francisco Chronicle Library, San Francisco, California, c. 1930 (?) EXTERIOR, GENERAL VIEW OF CONVENTO, FRONT VIEW, AFTER RESTORATION - Mission San Francisco Solano de Sonoma, First & Spain Streets, Sonoma, Sonoma County, CA

28. Photocopy of photograph (from San Francisco Chronicle Library, San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Photocopy of photograph (from San Francisco Chronicle Library, San Francisco, California, c. 1930 (?) EXTERIOR, DETAIL OF MISSION BELL IN FRONT OF CONVENTO, C. 1930 (?) - Mission San Francisco Solano de Sonoma, First & Spain Streets, Sonoma, Sonoma County, CA

77 FR 42647 - Safety Zone: San Diego Symphony POPS Fireworks; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... 1625-AA00 Safety Zone: San Diego Symphony POPS Fireworks; San Diego, CA AGENCY: Coast Guard, DHS... waters of San Diego Bay in support of the San Diego Symphony POPS Fireworks. This safety zone is... David Varela, Waterways Management, U.S. Coast Guard Sector San Diego, Coast Guard; telephone 619-278...

Arizona TeleMedicine Network: Engineering Master Plan.

ERIC Educational Resources Information Center

Atlantic Research Corp., Alexandria, VA.

As the planning document for establishing a statewide health communications system initially servicing the Papago, San Carlos and White Mountain Apache, Navajo, and Hopi reservations, this document prescribes the communications services to be provided by the Arizona TeleMedicine Network. Specifications include: (1) communications services for each…

75 FR 77756 - Safety Zone; San Diego Parade of Lights Fireworks, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

...-AA00 Safety Zone; San Diego Parade of Lights Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION... San Diego Bay in San Diego, CA in support of the two San Diego Parade of Lights Fireworks Displays on... and Purpose Fireworks and Stage FX America INC are sponsoring the San Diego Parade of Lights Fireworks...

Evaluation of the content and accessibility of web sites for accredited orthopaedic sports medicine fellowships.

PubMed

Mulcahey, Mary K; Gosselin, Michelle M; Fadale, Paul D

2013-06-19

The Internet is a common source of information for orthopaedic residents applying for sports medicine fellowships, with the web sites of the American Orthopaedic Society for Sports Medicine (AOSSM) and the San Francisco Match serving as central databases. We sought to evaluate the web sites for accredited orthopaedic sports medicine fellowships with regard to content and accessibility. We reviewed the existing web sites of the ninety-five accredited orthopaedic sports medicine fellowships included in the AOSSM and San Francisco Match databases from February to March 2012. A Google search was performed to determine the overall accessibility of program web sites and to supplement information obtained from the AOSSM and San Francisco Match web sites. The study sample consisted of the eighty-seven programs whose web sites connected to information about the fellowship. Each web site was evaluated for its informational value. Of the ninety-five programs, fifty-one (54%) had links listed in the AOSSM database. Three (3%) of all accredited programs had web sites that were linked directly to information about the fellowship. Eighty-eight (93%) had links listed in the San Francisco Match database; however, only five (5%) had links that connected directly to information about the fellowship. Of the eighty-seven programs analyzed in our study, all eighty-seven web sites (100%) provided a description of the program and seventy-six web sites (87%) included information about the application process. Twenty-one web sites (24%) included a list of current fellows. Fifty-six web sites (64%) described the didactic instruction, seventy (80%) described team coverage responsibilities, forty-seven (54%) included a description of cases routinely performed by fellows, forty-one (47%) described the role of the fellow in seeing patients in the office, eleven (13%) included call responsibilities, and seventeen (20%) described a rotation schedule. Two Google searches identified direct links for

41. Historic American Buildings Survey San Francisco CallBulletin Library San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Historic American Buildings Survey San Francisco Call-Bulletin Library San Francisco, California INTERIOR VIEW OF CHURCH BEFORE RESTORATION - 1934 - Mission San Carlos Borromeo, Rio Road & Lausen Drive, Carmel-by-the-Sea, Monterey County, CA

Yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia.

PubMed

Makinodan, Manabu; Yamauchi, Takahira; Tatsumi, Kouko; Okuda, Hiroaki; Noriyama, Yoshinobu; Sadamatsu, Miyuki; Kishimoto, Toshifumi; Wanaka, Akio

2009-01-01

The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.

76 FR 45693 - Safety Zone; San Diego POPS Fireworks, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

...-AA00 Safety Zone; San Diego POPS Fireworks, San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary... San Diego Bay in support of the San Diego POPS Fireworks. This safety zone is necessary to provide for... of the waterway during scheduled fireworks events. Persons and vessels will be prohibited from...

Acupuncture and Traditional Herbal Medicine Therapy Prevent Deliriumin Patients with Cardiovascular Disease in Intensive Care Units.

PubMed

Matsumoto-Miyazaki, Jun; Ushikoshi, Hiroaki; Miyata, Shusaku; Miyazaki, Nagisa; Nawa, Takahide; Okada, Hideshi; Ojio, Shinsuke; Ogura, Shinji; Minatoguchi, Shinya

2017-01-01

The aim of this study was to determine the effect of combination therapy consisting of acupuncture and traditional herbal medicine (Kampo medicine) for reducing the incidence rate of delirium in patients with cardiovascular (CV) disease in ICUs. Twenty-nine patients who had been urgently admitted to the ICU in the control period were treated with conventional intensive care. Thirty patients in the treatment period received conventional therapy plus a combination therapy consisting of acupuncture and herbal medicine. Acupuncture treatment was performed once a day, and the herbal formula was administered orally three times a day during the first week of the ICU stay. The standard acupuncture points were GV20, Ex-HN3, HT7, LI4, Liv3, and KI3, and the main herbal preparation was Kamikihito. The incident rates of delirium, assessed using the confusion assessment method for ICU, in the treatment and control period were compared. The incidence rate of delirium was significantly lower in the treatment group than in the control group (6.6% vs. 37.9%, [Formula: see text]). Moreover, sedative drugs and non-pharmacological approaches against aggressive behavior of patients who were delirious were used less in the treatment group than in the control group. No serious adverse events were observed in the treatment group. Combination therapy consisting of acupuncture and herbal medicine was found to be effective in lowering the incidence of delirium in patients with CV disease in ICUs. Further studies with a large sample size and parallel randomized controlled design would be required to establish the effects of this therapy.

Evaluation of the safety and adverse effects of goreisan/wulingsan, a traditional Japanese-chinese herbal formulation (kampo), in a rat model: a toxicological evaluation.

PubMed

Ahmed, Selim; Uchida, Ryuichi; Hussain, Maleeha; Kabir, Arm Luthful; Rahman, Mohammed Zakiur; Rahman, Mohammad Sharifur; Honda, Sumihisa; Rashid, Mohammad Abdur

2014-09-01

Diarrhea is the second leading cause of death among children less than 5 years of age. Most of these deaths occur in developing countries in the tropical areas of Africa and South Asia. Goreisan/Wulingsan, a formula of Japanese-Chinese medicinal herbs (Kampo), has been used for the treatment of diarrhea and vomiting from ancient times in East Asia. Therefore, we planned a randomized controlled clinical trial of Goreisan/Wulingsan in Bangladeshi children. Although it is believed to be safe in East Asia, information regarding its toxicity on animals is scarce. Since Goreisan/Wulingsan has never been used in Bangladesh, it was necessary to ensure the safety of the formula in an animal experiment. Rats were assigned to a control group (normal saline, n = 4) or various Goreisan/Wulingsan groups (n = 26) receiving doses of 1 to 8 mg/g/day (7.7 to 61.5 times the recommended pediatric dose) over a period of 25 days. Their activities and health conditions were observed until they were sacrificed, after which blood samples were collected for biochemical liver function tests. The kidneys, liver and heart tissue were collected for histopathological study. No lethality was observed during the experiment. All of the rats consumed the doses completely and no constipation was observed, suggesting the absence of any inhibitory effect on intestinal motion. Also, no abnormal neurological activity was detected, nor any significant elevation of AST, ALT or ALP levels, except for AST and ALT at the highest dose of 8 mg/g/day. Histopathological studies of the kidneys, liver and heart tissues revealed no abnormalities. In conclusion, our results showed that Goreisan/Wulingsan is safe for rats, thereby justifying the use of the drug in a human trial.

Leadership lessons from curricular change at the University of California, San Francisco, School of Medicine.

PubMed

Loeser, Helen; O'Sullivan, Patricia; Irby, David M

2007-04-01

After successive Liaison Committee on Medical Education accreditation reports that criticized the University of California, San Francisco, School of Medicine for lack of instructional innovation and curriculum oversight, the dean issued a mandate for curriculum reform in 1997. Could a medical school that prided itself on innovation in research and health care do the same in education? The authors describe their five-phase curriculum change process and correlate this to an eight-step leadership model. The first phase of curricular change is to establish a compelling need for change; it requires leaders to create a sense of urgency and build a guiding coalition to achieve action. The second phase of curriculum reform is to envision a bold new curriculum; leaders must develop such a vision and communicate it broadly. The third phase is to design curriculum and obtain the necessary approvals; this requires leaders to empower broad-based action and generate short-term wins. In the fourth phase, specific courses are developed for the new curriculum, and leaders continue to empower broad-based action, generate short-term wins, consolidate gains, and produce more change. During the fifth phase of implementation and evaluation, leaders need to further consolidate gains, produce more change, and anchor new approaches in the institution. Arising from this experience and the correlation of curricular change phases with leadership steps, the authors identify 27 specific leadership strategies they employed in their curricular reform process.

Gain-loss study of lower San Pedro Creek and the San Antonio River, San Antonio, Texas, May-October 1999

USGS Publications Warehouse

Ockerman, Darwin J.

2002-01-01

Five streamflow gain-loss measurement surveys were made along lower San Pedro Creek and the San Antonio River from Mitchell Street to South Loop 410 east of Kelly Air Force Base in San Antonio, Texas, during May–October 1999. All of the measurements were made during dry periods, when stormwater runoff was not occurring and effects of possible bank storage were minimized. San Pedro Creek and the San Antonio River were divided into six subreaches, and streamflow measurements were made simultaneously at the boundaries of these subreaches so that streamflow gains or losses and estimates of inflow from or outflow to shallow ground water could be quantified for each subreach. There are two possible sources of ground-water inflow to lower San Pedro Creek and the San Antonio River east of Kelly Air Force Base. One source is direct inflow of shallow ground water into the streams. The other source is ground water that enters tributaries that flow into the San Antonio River. The estimated mean direct inflow of ground water to the combined San Pedro Creek and San Antonio River study reach was 3.0 cubic feet per second or 1.9 million gallons per day. The mean tributary inflow of ground water was estimated to be 1.9 cubic feet per second or 1.2 million gallons per day. The total estimated inflow of shallow ground water was 4.9 cubic feet per second or 3.2 million gallons per day. The amount of inflow from springs and seeps (estimated by observation) is much less than the amount of direct ground-water inflow estimated from the gain-loss measurements. Therefore, the presence of springs and seeps might not be a reliable indicator of the source of shallow ground water entering the river. Most of the shallow ground water that enters the San Antonio River from tributary inflow enters from the west side, through Concepcion Creek, inflows near Riverside Golf Course, and Six-Mile Creek. 

76 FR 38305 - Safety Zone; San Francisco Chronicle Fireworks Display, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG 2011-0402] Safety Zone; San Francisco Chronicle Fireworks Display, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION... annual San Francisco Chronicle Fireworks Display (Independence Day Celebration for the City of San...

Topographical map of San Bernadina and San Gabriel mountains

NASA Image and Video Library

2000-02-04

JSC2000E01554 (January 2000) --- This is a shaded relief depiction of the same data set found in JSC2000-E-01553. Radar imagery, such as that to be provided by SRTM, is instrumental in creating these types of topographic models. Both images depict the San Bernadino and San Gabriel Mountains in California, north of Los Angeles. Cajon Junction and Cajon Pass, as well as part of the San Andreas fault line, are clearly seen.

The effects of the Kampo medicine (Japanese herbal medicine) "Daikenchuto" on the surgical inflammatory response following laparoscopic colorectal resection.

PubMed

Yoshikawa, Kozo; Shimada, Mitsuo; Nishioka, Masanori; Kurita, Nobuhiro; Iwata, Takashi; Morimoto, Shinya; Miyatani, Tomohiko; Komatsu, Masato; Kashihara, Hideya; Mikami, Chie

2012-07-01

The inflammatory response after surgery is associated with various postoperative complications. The aim of the present prospective study was to evaluate the effects of Daikenchuto (DKT) (a Japanese herbal medicine) on the inflammatory response in patients following laparoscopic colorectal resection. Thirty patients who underwent laparoscopic colectomy for colorectal carcinoma were divided into two groups: a DKT intake group (D group, n = 15) and a control group (C group, n = 15). The D group took 7.5 g/day of DKT from the day after surgery until the 7th postoperative day. The body temperature, heart rate, WBC count, lymphocyte count, C-reactive protein (CRP) level, β-D: -glucan level and Candida index were compared between the two groups. The patients' mean age in the D group was significantly younger than that in the C group. D3 lymph node dissection was performed more often in the D group. The time until first flatus was significantly shorter in the D group (1.8 ± 0.5 days) than in the C group (2.7 ± 0.5 days). The CRP level was significantly lower in the D group (4.6 ± 0.6 mg/dl) than in the C group (8.3 ± 1.1 mg/dl) on the 3rd postoperative day. Postoperative DKT administration significantly suppressed the CRP level and shortened the time until first flatus. DKT administration also significantly suppressed postoperative inflammation following surgery for colorectal cancer.

Public Involvement and Response Plan (Community Relations Plan), Presidio of San Francisco, San Francisco, California

DTIC Science & Technology

1992-03-01

Oty_ Population City Population San Jose 782,248 Santa Clara 92,090 San Francisco 763,800 Daly City 91,209 Oakland 372,000 San Mateo 84,829...Oakland Tribune P.O. Box 24424 Oakland, CA 94623 (415) 645-2000/2771 DAILY NEWSPAPERS (cont’d) Editor San Jose Mercury-News P.O. Box 5533 750 Ridder...Park Drive San Jose , CA 95190 (408) 920-5000/288-8060 Editor San Mateo Times P.O. Box 5400 1080 S. Amphlett San Mateo, CA 94402 (415) 348

The comparative clinical study of efficacy of Gamisoyo-San (Jiaweixiaoyaosan) on generalized anxiety disorder according to differently manufactured preparations: multicenter, randomized, double blind, placebo controlled trial.

PubMed

Park, Dae-Myung; Kim, Seok-Hwan; Park, Yang-Chun; Kang, Wee-Chang; Lee, Sang-Ryong; Jung, In-Chul

2014-12-02

Gamisoyo-San (GSS) is a well-known Traditional Korean Medicine shown to be effective on mood disorders. The purpose of this research is to examine the effect of Gamisoyo-San on generalized anxiety disorder by its differently manufactured preparations. Multicenter, randomized, double-blinded, placebo-controlled study was set for 147 patients with generalized anxiety disorder recruited from November 1st 2009 to December 16th 2010. They were given Gamisoyo-San individual extract mixture (extraction done for each crude materia medica separately) or Gamisoyo-San multi-compound extract (extraction done for whole materia medica at once) or controlled medication. Hamilton Rating Scale for Anxiety (HAM-A), Korean State-Trait Anxiety Inventory (K-STAI), Penn State Worry Questionnaire (PSWQ), Korean Beck Depression Inventroy (K-BDI), Symptom Checklist-90-Revised (SCL-90-R), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were evaluated. We also applied Pattern Identification tool for 'JingJi and ZhengChong (, Traditional Korean Medicine term which correlates with generalized anxiety disorder)' to patients to evaluate different responses among 9 patterns. HAM-A scores of Gamisoyo-San multi-compound extract group showed greater decrease compared to Gamisoyo-San individual extract mixture group and placebo group, but the difference was insignificant. WHOQOL-BREF scores of Gamisoyo-San multi-compound extract group showed significant increase compared to Gamisoyo-San individual extract mixture group and placebo group. In Heart blood deficiency pattern, the Gamisoyo-San multi-compound extract group showed significant decrease in K-BDI compared to the Gamisoyo-San individual extract mixture group. Gamisoyo-San did not improve anxiety level of GAD patients. However, it can be useful to improve quality of life, and reduce depressive, obsessive-compulsive, somatic symptoms of generalized anxiety disorder. Gamisoyo-San multi-compound seemed more effective than

Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica.

PubMed

Chan, Kelvin; Shaw, Debbie; Simmonds, Monique S J; Leon, Christine J; Xu, Qihe; Lu, Aiping; Sutherland, Ian; Ignatova, Svetlana; Zhu, You-Ping; Verpoorte, Rob; Williamson, Elizabeth M; Duez, Pierre

2012-04-10

Studies on traditional Chinese medicine (TCM), like those of other systems of traditional medicine (TM), are very variable in their quality, content and focus, resulting in issues around their acceptability to the global scientific community. In an attempt to address these issues, an European Union funded FP7 consortium, composed of both Chinese and European scientists and named "Good practice in traditional Chinese medicine" (GP-TCM), has devised a series of guidelines and technical notes to facilitate good practice in collecting, assessing and publishing TCM literature as well as highlighting the scope of information that should be in future publications on TMs. This paper summarises these guidelines, together with what has been learned through GP-TCM collaborations, focusing on some common problems and proposing solutions. The recommendations also provide a template for the evaluation of other types of traditional medicine such as Ayurveda, Kampo and Unani. GP-TCM provided a means by which experts in different areas relating to TCM were able to collaborate in forming a literature review good practice panel which operated through e-mail exchanges, teleconferences and focused discussions at annual meetings. The panel involved coordinators and representatives of each GP-TCM work package (WP) with the latter managing the testing and refining of such guidelines within the context of their respective WPs and providing feedback. A Good Practice Handbook for Scientific Publications on TCM was drafted during the three years of the consortium, showing the value of such networks. A "deliverable - central questions - labour division" model had been established to guide the literature evaluation studies of each WP. The model investigated various scoring systems and their ability to provide consistent and reliable semi-quantitative assessments of the literature, notably in respect of the botanical ingredients involved and the scientific quality of the work described. This

77 FR 15260 - Safety Zone; San Francisco Fireworks Display, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

... Zone; San Francisco Fireworks Display, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION: Notice of... Fireworks Display in the Captain of the Port, San Francisco area of responsibility during the dates and... hazards associated with the fireworks display. During the enforcement period, unauthorized persons or...

Military Medicine for the Twenty-First Century: ’To Shape the Future’

DTIC Science & Technology

1992-04-10

34, U.S. Medicine, Uol 27, May 1991, pp. 1, 17. 63. Ibid. 64. Kussman Interview. 65. Ibid. 66. Ibid. 67. "San Antonio JMMC To Be Replaced", U.S. Medicine...States Navu. New York: Random House, 1991. Kussman , Michael J., COL, MC, USA, former Deputy Commmander for Clinical Services of the Brooke Army Medical

2. Historic American Buildings Survey San Francisco Chronicle Library San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey San Francisco Chronicle Library San Francisco, California Year Built: 1834 Photo Taken: About 1925 VIEW FROM EAST - General Sherman Quarters, 464 Calle Principal, Monterey, Monterey County, CA

2007 San Diego wildfires and asthmatics.

PubMed

Vora, Chirag; Renvall, Marian J; Chao, Peter; Ferguson, Paul; Ramsdell, Joe W

2011-02-01

This case series reports the changes in the respiratory health of eight asthmatic subjects and the relationship with air quality associated with the October 2007 firestorm in San Diego County of California. Participants were eight subjects with asthma enrolled in Asthma Clinical Research Network (ACRN) (NIH# U10-HL074218) studies at the University of California San Diego (UCSD), School of Medicine, who had study data collected immediately prior, during and 1 month after the 5-day firestorm in San Diego County. Air quality deteriorated to an extreme average of 71.5 mg/m(3) small particulate matter less than 2.5 μm (PM(2.5)) during the firestorm. Respiratory health data included morning and evening peak expiratory flow rates (PEFR), morning and evening Forced Expiratory Volume in one second (FEV(1)), rescue medication usage, and sputum eosinophils. Morning and evening PEFR and FEV(1) rates remained stable. The two subjects tested during the fires had elevated eosinophil counts and rescue medication usage was increased in five of the eight subjects. Pulmonary function test values were stable during the wildfires for all eight subjects but there was a statistically significant increase in rescue medication usage during the wildfires that correlated with PM(2.5) values. The two subjects tested during the fires showed increases in sputum eosinophil counts consistent with increased airways inflammation. These findings suggest that poor air quality associated with wildfires resulted in an increase in airways inflammation in these asthmatic subjects, but pulmonary function tests remained stable, possibly due to increased rescue medication usage. This is especially pertinent as there is an increase in incidence of wildfires this decade.

2007 San Diego Wildfires And Asthmatics

PubMed Central

Vora, Chirag; Renvall, Marian J.; Chao, Peter; Ferguson, Paul; Ramsdell, Joe W.

2011-01-01

Context This case series reports the changes in the respiratory health of eight asthmatic subjects and the relationship to air quality associated with the October, 2007 firestorm in San Diego County of California. Case Presentation Participants were eight subjects with asthma enrolled in Asthma Clinical Research Network (ACRN) (NIH# U10-HL074218) studies at the University of California San Diego, School of Medicine, (UCSD), who had study data collected immediately prior, during and one month after the five-day firestorm in San Diego County. Air quality deteriorated to an extreme average of 71.5 ug/m3small particulate matter less than 2.5 microns (PM2.5) during the firestorm. Respiratory health data included morning and evening peak expiratory flow rates [PEFR], morning and evening Forced Expiratory Volume in one second [FEV1], rescue medication usage, and sputum eosinophils. Morning and evening PEFR and FEV1 rates remained stable. The two subjects tested during the fires had elevated eosinophil counts and rescue medication usage was increased in five of the eight subjects. Discussion Pulmonary function test values were stable during the wildfires for all eight subjects but there was a statistical significant increase in rescue medication usage during the wildfires which correlated with PM 2.5 values. The two subjects tested during the fires showed increases in sputum eosinophil counts consistent with increased airways inflammation. Relevance These findings suggests that poor air quality associated with wildfires resulted in an increase airways inflammation in these asthmatic subjects, but pulmonary function tests remained stable, possibly due to increased rescue medication usage. This is especially pertinent as there is an increase in incidence of wildfires this decade. PMID:21158525

76 FR 55796 - Safety Zone; TriRock Triathlon, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

...-AA00 Safety Zone; TriRock Triathlon, San Diego Bay, San Diego, CA AGENCY: Coast Guard, DHS. ACTION.... Basis and Purpose Competitor Group is sponsoring the TriRock Triathlon, consisting of 2000 swimmers.... 165.T11-431 to read as follows: Sec. 165.T11-431 Safety Zone; TriRock Triathlon, San Diego Bay, San...

San Marco-C Explorer

NASA Technical Reports Server (NTRS)

1971-01-01

On or about 24 April 1971, the San Marco-C spacecraft will be launched from the San Marco Range located off the coast of Kenya, Africa, by a Scout launch vehicle. The launch will be conducted by an Italian crew. The San Marco-C is the third cooperative satellite project between Italy and the United States. The first such cooperative project resulted in the San Marco-1 satellite which was launched into orbit from the Wallops Island Range with a Scout vehicle on 15 December 1964. The successful launch demonstrated the readiness of the Italian Centro Ricerche Aerospaziuli (CRA) launch crews to launch the Scout vehicle and qualified the basic spacecraft design. The second in the series of cooperative satellite launches was the San Marco-II which was successfully launched into orbit from the San Marco Range on 26 April 1967. This was the first Scout launch from the San Marco Range. The San Marco-II carried the same accelerometer as San Marco-1, but the orbit permitted the air drag to be studied in detail in the equatorial region. The successful launch also served to qualify the San Marco Range as a reliable facility for future satellite launches, and has since been used for the successful launch of SAS-A (Explorer 42). This cooperative project has been implemented jointly by the Italian Space Commission and NASA. The CRA provided the spacecraft, its subsystems, and an air drag balance; Goddard Space Flight Center (GSFC) provided an omegatron and a neutral mass spectrometer, technical consultation and support. In addition, NASA provided the Scout launch vehicle. The primary scientific objective of the San Marco-C is to obtain, by measurement, a description of the equatorial neutral-particle atmosphere in terms of its density, com- position, and temperature at altitudes of 200 km and above, and to obtain a description of variations that result from solar and geomagnetic activities. The secondary scientific objective is to investigate the interdependence of three neutral

California coastal processes study: Skylab. [San Pablo and San Francisco Bays

NASA Technical Reports Server (NTRS)

Pirie, D. M.; Steller, D. D. (Principal Investigator)

1975-01-01

The author has identified the following significant results. In San Pablo Bay, the patterns of dredged sediment discharges were plotted over a three month period. It was found that lithogenous particles, kept in suspension by the fresh water from the Sacramento-San Joaquin, were transported downstream to the estuarine area at varying rates depending on the river discharge level. Skylab collected California coastal imagery at limited times and not at constant intervals. Resolution, however, helped compensate for lack of coverage. Increased spatial and spectral resolution provided details not possible utilizing Landsat imagery. The S-192 data was reformatted; band by band image density stretching was utilized to enhance sediment discharge patterns entrainment, boundaries, and eddys. The 26 January 1974 Skylab 4 imagery of San Francisco Bay was taken during an exceptionally high fresh water and suspended sediment discharge period. A three pronged surface sediment pattern was visible where the Sacramento-San Joaquin Rivers entered San Pablo Bay through Carquinez Strait.

Aerial photo of San Bernadina and San Gabriel mountains

NASA Image and Video Library

2000-02-04

JSC2000E01553 (January 2000) --- This USGS elevation model showing increasing elevation as increasing brightness is included here for comparison purposes with the high-resolution topographic elevation map image in E01554. Both images depict the San Bernadino and San Gabriel Mountains in California, north of Los Angeles.

78 FR 20792 - Safety Zone; San Francisco Giants Fireworks Display, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

... Zone; San Francisco Giants Fireworks Display, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION... Francisco Giants Fireworks Display in the Captain of the Port, San Francisco area of responsibility during... public from the hazards associated with the fireworks display. During the enforcement period...

77 FR 28771 - Safety Zone; San Francisco Giants Fireworks Display, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... Zone; San Francisco Giants Fireworks Display, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION... Francisco Giants Fireworks Display in the Captain of the Port, San Francisco area of responsibility during... public from the hazards associated with the fireworks display. During the enforcement period...

Antidepressant effects of Soyo-san on Immobilization stress in ovariectomized female rats.

PubMed

Oh, Jin Kyung; Kim, Yoon-Sang; Park, Hyun-Jung; Lim, Eun-Mee; Pyun, Kwang-Ho; Shim, Insop

2007-08-01

Soyo-san is a traditional oriental medicinal formula, a mixture of 9 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Soyo-san on repeated stress-induced alterations of learning and memory on a Morris water maze (MWM) task and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) and reactivity of acetylcholinesterase (AChE) in the hippocampus, and the serum levels of corticosterone were assessed after behavioral testing. The female rats were randomly divided into three groups: the nonoperated and nonstressed group (normal), the ovariectomized and stressed group (control), and the ovariectomized, stressed and Soyo-san treated group (SOY). The rats were exposed to immobilization stress (IMO) for 14 d (2 h/d), and Soyo-san (400 mg/kg, i.p.) was administered 30 min before IMO stress. Treatments with SOY caused significant reversals of the stress-induced deficits in learning and memory on a spatial memory task, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT and AChE reactivities (p<0.05, respectively). The serum level of corticosterone in the SOY group was significantly lower than that in the control group (p<0.05). These results suggest that Soyo-san might prove to be an effective antidepressant agent.

33 CFR 165.1102 - Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Loma; San Diego Bay, San Diego, CA. 165.1102 Section 165.1102 Navigation and Navigable Waters COAST... Guard District § 165.1102 Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA. (a) Location. The following area is a security zone: The water adjacent to the Naval Base Point Loma, San Diego...

33 CFR 165.1102 - Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Loma; San Diego Bay, San Diego, CA. 165.1102 Section 165.1102 Navigation and Navigable Waters COAST... Guard District § 165.1102 Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA. (a) Location. The following area is a security zone: The water adjacent to the Naval Base Point Loma, San Diego...

33 CFR 165.1102 - Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Loma; San Diego Bay, San Diego, CA. 165.1102 Section 165.1102 Navigation and Navigable Waters COAST... Guard District § 165.1102 Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA. (a) Location. The following area is a security zone: The water adjacent to the Naval Base Point Loma, San Diego...

3. Historic American Buildings Survey San Francisco Examiner Library San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey San Francisco Examiner Library San Francisco, California Photo Taken: About 1910 (From 'The Sperry Family' - Page 17) VIEW FROM NORTHEAST - First Theatre in California, Southwest corner of Pacific & Scott Streets, Monterey, Monterey County, CA

Origin of innate immune responses: revelation of food and medicinal applications.

PubMed

Cooper, Edwin L; Hirabayashi, Kyle

2013-10-01

Much is known about the strong ecological impact that earthworms ( Qiū Yǐn; Pheretima) have on soil in terms of fertility, nutrient production, and tilling. Even more interesting though is the impact they have had on our understanding of innate immunity, and from this discovery, there has been a simultaneous recognition of their potential through their historical use as food and their use in treatment of certain chronic health problems that often afflict humans. This bifurcating growing knowledge base has stemmed from centuries of honing and practicing traditional and complementary forms of medicine such as Ayurveda (India) Traditional Chinese Medicine (China), Kampo (Japan), and Traditional Korean Medicine (Korea). Earthworms (Dilong) have also been credited as a model for research concerning the nervous and endocrine systems. One of the reasons behind the earthworm's tremendous impact on research into these biomedical endeavors is partly due to its lack of ethical restrictions, like those imposed on vertebrate models. Using invertebrate models as opposed to mice or other mammalian models bypasses ethical concerns. Moreover, financial constraints consistently hover over biological research that requires living subjects, preferably mammals. Earthworms are a rich source of several vital biological macromolecules and other nutrients. They have long been used as food in several cultures such as the Ye'Kuana in Venezuela, the Maori in New Zealand, and the nomadic populations in Papua New Guinea. Earthworms and their nutritious products have been shown to exert significant effects in treating humans for disorders of inflammation and blood coagulation. One area that continues to be examined is the earthworm's ability to regenerate lost appendages, and these effects have been extended to mammals. Evidence reveals that earthworm extracts may actually promote the regeneration of damaged nerves. This presentation will explore how earthworms may reveal significant advances

76 FR 1386 - Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

...-AA00 Safety Zone; Centennial of Naval Aviation Kickoff, San Diego Bay, San Diego, CA AGENCY: Coast... zone on the navigable waters of San Diego Bay in San Diego, CA in support of the Centennial of Naval... February 12, 2010, the Centennial of Naval Aviation Kickoff will take place in San Diego Bay. In support of...

Vertical tectonic deformation associated with the San Andreas fault zone offshore of San Francisco, California

USGS Publications Warehouse

Ryan, H.F.; Parsons, T.; Sliter, R.W.

2008-01-01

A new fault map of the shelf offshore of San Francisco, California shows that faulting occurs as a distributed shear zone that involves many fault strands with the principal displacement taken up by the San Andreas fault and the eastern strand of the San Gregorio fault zone. Structures associated with the offshore faulting show compressive deformation near where the San Andreas fault goes offshore, but deformation becomes extensional several km to the north off of the Golden Gate. Our new fault map serves as the basis for a 3-D finite element model that shows that the block between the San Andreas and San Gregorio fault zone is subsiding at a long-term rate of about 0.2-0.3??mm/yr, with the maximum subsidence occurring northwest of the Golden Gate in the area of a mapped transtensional basin. Although the long-term rates of vertical displacement primarily show subsidence, the model of coseismic deformation associated with the 1906 San Francisco earthquake indicates that uplift on the order of 10-15??cm occurred in the block northeast of the San Andreas fault. Since 1906, 5-6??cm of regional subsidence has occurred in that block. One implication of our model is that the transfer of slip from the San Andreas fault to a fault 5??km to the east, the Golden Gate fault, is not required for the area offshore of San Francisco to be in extension. This has implications for both the deposition of thick Pliocene-Pleistocene sediments (the Merced Formation) observed east of the San Andreas fault, and the age of the Peninsula segment of the San Andreas fault.

San Marino.

PubMed

1985-02-01

San Marino, an independent republic located in north central Italy, in 1983 had a population of 22,206 growing at an annual rate of .9%. The literacy rate is 97% and the infant mortality rate is 9.6/1000. The terrain is mountainous and the climate is moderate. According to local tradition, San Marino was founded by a Christian stonecutter in the 4th century A.D. as a refuge against religious persecution. Its recorded history began in the 9th century, and it has survived assaults on its independence by the papacy, the Malatesta lords of Rimini, Cesare Borgia, Napoleon, and Mussolini. An 1862 treaty with the newly formed Kingdom of Italy has been periodically renewed and amended. The present government is an alliance between the socialists and communists. San Marino has had its own statutes and governmental institutions since the 11th century. Legislative authority at present is vested in a 60-member unicameral parliament. Executive authority is exercised by the 11-member Congress of State, the members of which head the various administrative departments of the goverment. The posts are divided among the parties which form the coalition government. Judicial authority is partly exercised by Italian magistrates in civil and criminal cases. San Marino's policies are tied to Italy's and political organizations and labor unions active in Italy are also active in San Marino. Since World War II, there has been intense rivalry between 2 political coalitions, the Popular Alliance composed of the Christian Democratic Party and the Independent Social Democratic Party, and the Liberty Committee, coalition of the Communist Party and the Socialist Party. San Marino's gross domestic product was $137 million and its per capita income was $6290 in 1980. The principal economic activities are farming and livestock raising, along with some light manufacturing. Foreign transactions are dominated by tourism. The government derives most of its revenue from the sale of postage stamps to

Abrupt along-strike change in tectonic style: San Andreas fault zone, San Francisco Peninsula

USGS Publications Warehouse

Zoback, M.L.; Jachens, R.C.; Olson, J.A.

1999-01-01

Seismicity and high-resolution aeromagnetic data are used to define an abrupt change from compressional to extensional tectonism within a 10- to 15-km-wide zone along the San Andreas fault on the San Francisco Peninsula and offshore from the Golden Gate. This 100-km-long section of the San Andreas fault includes the hypocenter of the Mw = 7.8 1906 San Francisco earthquake as well as the highest level of persistent microseismicity along that ???470-km-long rupture. We define two distinct zones of deformation along this stretch of the fault using well-constrained relocations of all post-1969 earthquakes based a joint one-dimensional velocity/hypocenter inversion and a redetermination of focal mechanisms. The southern zone is characterized by thrust- and reverse-faulting focal mechanisms with NE trending P axes that indicate "fault-normal" compression in 7- to 10-km-wide zones of deformation on both sides of the San Andreas fault. A 1- to 2-km-wide vertical zone beneath the surface trace of the San Andreas is characterized by its almost complete lack of seismicity. The compressional deformation is consistent with the young, high topography of the Santa Cruz Mountains/Coast Ranges as the San Andreas fault makes a broad restraining left bend (???10??) through the southernmost peninsula. A zone of seismic quiescence ???15 km long separates this compressional zone to the south from a zone of combined normal-faulting and strike-slip-faulting focal mechanisms (including a ML = 5.3 earthquake in 1957) on the northernmost peninsula and offshore on the Golden Gate platform. Both linear pseudo-gravity gradients, calculated from the aeromagnetic data, and seismic reflection data indicate that the San Andreas fault makes an abrupt ???3-km right step less than 5 km offshore in this northern zone. A similar right-stepping (dilatational) geometry is also observed for the subparallel San Gregorio fault offshore. Persistent seismicity and extensional tectonism occur within the San

Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats

PubMed Central

2014-01-01

Background Soyo-san is a traditional oriental medicinal formula, a mixture of 9 crude drugs, and it has been clinically used for treating mild depressive disorders. The role of pro- and anti-inflammatory cytokines in psychiatric disorders has been the focus of great research attention in recent years. In the present study, we detected the antidepressant effect of soyo-san in the ovariectomized and repeated stressed female rats. Methods This study was designed to evaluate the antidepressant-like effect of soyo-san on the forced swimming test (FST). The rats were randomly divided into the following groups: the nonoperated and nonstressed group (non-op), the nonoperated and stressed group (non-op + ST), the ovariectomized and stress group (OVX) and sham operated and stressed group (sham), the ovariectomized and stressed group (OVX + ST), the ovariectomized, stressed and soyo-san 100 mg/kg treated group (SOY100) and the ovariectomized, stressed and soyo-san 400 mg/kg treated group (SOY400). The rats were exposed to immobilization stress (IMO) for 14day (2 h/14day), and soyo-san (100 mg/kg and 400 mg/kg) was administrated during the same time. In the same animals, the levels of corticosterone and interleukin-1-beta (IL-1β) were examined in the serum. Also, the change of IL-1β expression in brain regions was examined after behavior test. Results In the FST, the lower dose (100 mg/kg) of extract was effective in reducing immobility, along with an increase in swimming time. The serum levels of corticosterone and IL-1β in the SOY groups were significantly lower than those in the control group. In the brain, the expression of IL-1β positive neurons in the control group were significantly increased in the paraventricular nucleus (PVN) and hippocampus compared to the non-op. However, soyo-san groups significantly reduced the IL-1β-ir neurons in the PVN and hippocampal regions compared to the control. Conclusion The present results demonstrated that soyo-san

Medicinal ethnobotany in Huacareta (Chuquisaca, Bolivia)

PubMed Central

2012-01-01

Background The aim of this study was to document the types of diseases treated by the use of medicinal plants, their main applications and also to have a report of the major diseases treated at the Hospital of San Pablo de Huacareta (Chuquisaca Bolivia). Methods We conducted semi-structured interviews on the use medicinal plants with 10 local informants, and categorized the kinds of diseases treated by traditional medicine. We obtained reports of cases treated at the Hospital of Huacareta in order to compare the use frequency of traditional medicine and allopathic medicine for the treatment of recurrent diseases in the area. Results Our survey identified 258 traditional medicine uses, spanning a total of 13 diseases categories and including 91 native and exotic plant species and one unidentified sample plant type. Gastrointestinal disorders (55%) were most frequently treated with medicinal plants, followed by afflictions of the musculoskeletal system (25%) and dermatological disorders (24%). Hospital information indicates that the most common diseases are acute respiratory infections (47%) and acute diarrheal diseases (37%). The herbal remedies were mostly used in the form of teas and decoctions. The informants used mainly native plant species, although exotic species has been introduced to the pharmacopoeia. Conclusions The treatment of gastrointestinal disorders is the primary objective of the medical ethnobotany of the inhabitants of Huacareta, while respiratory system diseases are mostly treated in the hospital. Looking at the data from the Hospital records we can infer that gastrointestinal disorders are among the most common diseases in the study area. For most respondents, traditional medicine is a reliable choice for the care of their illnesses. However, the preference of the population for either traditional medicine or allopathic medicine needs to be clarified in future comparative studies to obtain more convincing results. The results presented can be

76 FR 75908 - Notice of Inventory Completion: The University of California, San Diego, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... University of California, San Diego, San Diego, CA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Regents of the University of California on behalf of the University of California, San Diego... culturally affiliated with the human remains may contact the University of California, San Diego. Disposition...

77 FR 34988 - Notice of Inventory Completion: San Diego State University, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... State University appears to have been collected from back dirt by an unknown student and brought back to... Inventory Completion: San Diego State University, San Diego, CA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: San Diego State University Archeology Collections Management Program has...

Underwater gravity meter survey of San Francisco and San Pablo bays, California, 1982

USGS Publications Warehouse

Childs, Jonathan R.; Beyer, L.A.; McCulloch, D.S.; McHendrie, G.A.; Steele, W.C.

1983-01-01

Seafloor gravity measurements were made at 281 bottom stations in San Francisco and San Pablo Bays, California, on a series of lines oriented approximately NNE.. Line spacing was approximately 2.8 km and stations along the lines mere spaced 0.5 to 1.5 km apart, between 0.5 and 1.5 km perpendicular to the axis. Sample Bouguer anomalies in the San Francisco Bay range from -15 to +15 mGals (?0.1 mgal), while anomalies in the San Pablo Bay are consistently negative, ranging from +4.0 to -40.0 mGal (?0.2 mGal).

78 FR 38584 - Safety Zone; San Diego Symphony Summer POPS Fireworks 2013 Season, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... 1625-AA00 Safety Zone; San Diego Symphony Summer POPS Fireworks 2013 Season, San Diego, CA AGENCY... on the navigable waters of San Diego Bay in support of the San Diego Symphony Summer POPS Fireworks... Diego, Coast Guard; telephone 619-278-7656, email [email protected] . If you have...

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Guard District § 165.1141 Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA. (a) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente... Safety Zone, San Clemente Island, CA. 165.1141 Section 165.1141 Navigation and Navigable Waters COAST...

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Guard District § 165.1141 Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA. (a) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente... Safety Zone, San Clemente Island, CA. 165.1141 Section 165.1141 Navigation and Navigable Waters COAST...

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Guard District § 165.1141 Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA. (a) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente... Safety Zone, San Clemente Island, CA. 165.1141 Section 165.1141 Navigation and Navigable Waters COAST...

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Guard District § 165.1141 Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA. (a) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente... Safety Zone, San Clemente Island, CA. 165.1141 Section 165.1141 Navigation and Navigable Waters COAST...

33 CFR 165.1141 - Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Guard District § 165.1141 Safety Zone; San Clemente 3 NM Safety Zone, San Clemente Island, CA. (a) Location. The following area is a safety zone: All waters of the Pacific Ocean surrounding San Clemente... Safety Zone, San Clemente Island, CA. 165.1141 Section 165.1141 Navigation and Navigable Waters COAST...

Zootherapeutic practices in Aquismón, San Luis Potosí, México.

PubMed

Alonso-Castro, Angel Josabad; Carranza-Álvarez, Candy; Maldonado-Miranda, Juan José; Del Rosario Jacobo-Salcedo, María; Quezada-Rivera, Diana Alicia; Lorenzo-Márquez, Habacuc; Figueroa-Zúñiga, Luis Alejandro; Fernández-Galicia, Carlos; Ríos-Reyes, Néstor Abel; de León-Rubio, Miguel Ángel; Rodríguez-Gallegos, Valentina; Medellín-Milán, Pedro

2011-10-31

Animal derived products have been a source of medicinal compounds since ancient times. This work documents the use of animal species in traditional medicine in the municipality of Aquismón, San Luis Potosí, México. Direct interviews were performed with inhabitants from Aquismón. The interviews were analyzed with two quantitative tools: (a) the informant consensus (ICF) that estimates the level of agreement about which animals may be used for each category and (b) the relative importance (RI) that determines the extent of potential utilization of each species. A total of 24 animal species used for medicinal purposes, belonging to 22 families and 4 taxonomic categories, were reported by interviewees. Nine medicinal species had not been reported in scientific literature. The results of the IFC showed that diseases of the respiratory systems had the greatest agreement. The most versatile species according to their RI are Crotalus atrox and Mephitis macroura. Further studies with medicinal fauna from Aquismón are required for the experimental validation of their traditional uses, especially with Mephitis macroura and Crotalus atrox. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico 165.776 Section 165.776 Navigation and Navigable Waters COAST... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a...

33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico 165.776 Section 165.776 Navigation and Navigable Waters COAST... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico (a...

33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. 165.776 Section 165.776 Navigation and Navigable Waters COAST... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. (a...

33 CFR 165.776 - Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. 165.776 Section 165.776 Navigation and Navigable Waters COAST... Guard District § 165.776 Security Zone; Coast Guard Base San Juan, San Juan Harbor, Puerto Rico. (a...

Keeping Up-To-Date: The San Antonio CATs Initiative

PubMed Central

Rugh, John D.; Hendricson, William D.; Hatch, John P.; Glass, Birgit J.

2010-01-01

There is evidence from medicine that schools and practitioners are slow to adopt new and proven effective treatments while marketing efforts lead practitioners to too quickly adopt unproven modalities. To address these problems, the dental school at the University of Texas Health Sciences Center at San Antonio, has developed a program designed to teach students, faculty, and practitioners the skills of accessing the literature as an intrinsic part of treatment. The Critically Appraised Topics (CATs) program is described and evidence is presented showing that participants can be taught to prepare high-quality summaries of the literature pertinent to clinical problems. PMID:20836411

33 CFR 110.224 - San Francisco Bay, San Pablo Bay, Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Bay, Sacramento River, San Joaquin River, and connecting waters, CA. (a) General regulations. (1..., Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin River, and connecting waters, CA. 110.224... notified to move by the Captain of the Port. (4) No vessel may anchor within a tunnel, cable, or pipeline...

33 CFR 110.224 - San Francisco Bay, San Pablo Bay, Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Bay, Sacramento River, San Joaquin River, and connecting waters, CA. (a) General regulations. (1..., Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin River, and connecting waters, CA. 110.224... notified to move by the Captain of the Port. (4) No vessel may anchor within a tunnel, cable, or pipeline...

33 CFR 110.224 - San Francisco Bay, San Pablo Bay, Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Bay, Sacramento River, San Joaquin River, and connecting waters, CA. (a) General regulations. (1..., Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin River, and connecting waters, CA. 110.224... notified to move by the Captain of the Port. (4) No vessel may anchor within a tunnel, cable, or pipeline...

75 FR 39166 - Safety Zone; San Francisco Giants Baseball Game Promotion, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

...-AA00 Safety Zone; San Francisco Giants Baseball Game Promotion, San Francisco, CA AGENCY: Coast Guard... Francisco Giants Baseball Game Promotion. This safety zone is established to ensure the safety of... Game Promotion on July 16, 2010, on the navigable waters of McCovey Cove, in San Francisco Bay, off of...

77 FR 70891 - Safety Zone; Bay Bridge Construction, San Francisco Bay, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-28

...-AA00 Safety Zone; Bay Bridge Construction, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard... the navigable waters of the San Francisco Bay near Yerba Buena Island, CA in support of the Bay Bridge... construction of the Bay Bridge, the safety zone is necessary to provide for the safety of mariners transiting...

Traditional Chinese medicine typing of affective disorders and treatment.

PubMed

Zhang, L D; Zhang, Y L; Xu, S H; Zhou, G; Jin, S B

1994-01-01

According to the theory of Traditional Chinese Medicine (TCM), 50 patients with affective disorders were typed into the categories of depressed liver resulting in fire, mild Yang deficiency and mild Yin deficiency and were treated with Xiao Yao San Jia Wei. The results are 26 patients with marked improvement, 17 patients with improvement and 7 patients with no improvement.

77 FR 36041 - San Antonio Central Railroad, L.L.C.-Lease Exemption-Port Authority of San Antonio

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35603] San Antonio Central Railroad, L.L.C.--Lease Exemption--Port Authority of San Antonio San Antonio Central Railroad, L.L... in Wacto Holdings, Inc.--Continuance in Control Exemption--San Antonio Central Railroad, L.L.C...

33 CFR 165.T11-630 - Safety zone; Giants Enterprises Fireworks Display, San Francisco Bay, San Francisco, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Francisco Bay, San Francisco, CA. (a) Location. This temporary safety zone is established in the navigable waters of the San Francisco Bay near Pier 48 in San Francisco, CA as depicted in National Oceanic and... Fireworks Display, San Francisco Bay, San Francisco, CA. 165.T11-630 Section 165.T11-630 Navigation and...

San Marco D/L Explorer

NASA Technical Reports Server (NTRS)

1988-01-01

ti March 26, 1964, Centro Ricerche Aerospaziali (CRA) successfully launched a two-stage Nike sounding rocket from the Santa Rita launch platform off the Kenya coast, concluding Phase I. It carried basic elements of the San Marco science instrumentation and served further to flight qualify these canponents as well as provide a means of check-out of range instrumentation and equipment. The second phase culminated in the launch of the San Marco-I Spacecraft fran Wallops Island on a Scout vehicle on December 15, 1964. This launch derronstrated the readiness of the CRA launch crews for Phase III operations and qualified the basic spacecraft design. In addition it confirmed the usefulness and reliability of the drag balance device for accurate determinations of air density values and satellite attitude. phase III was completed with the launching of San Marco-11 frcm the San Marco platform off the coast of Kenya on April 26, 1967. ?he San Marco-II carried the same instrunentation as the San Marco-I, but the equatorial orbit permitted a more detailed study to be made of density variations versus altitude in the equatorial region. Ihe successful launch also served to qualify the San Marco Range as a reliable facility for future satellite launches. The successful culmination of the first San Marco endeavor paved the way for still closer collaboration in future space explorations.

Antiinflammatory and Hepatoprotective Medicinal Herbs as Potential Substitutes for Bear Bile.

PubMed

Appiah, Sandra; Revitt, Mike; Jones, Huw; Vu, Milan; Simmonds, Monique; Bell, Celia

2017-01-01

Practitioners of traditional Chinese medicine (TCM) commonly prescribe medicinal formulations relying on the purported synergism of a combination of plant species, sometimes incorporating animal parts and minerals. Bear bile, obtained from either wild or farmed bears, is a commonly used constituent of traditional medicine formulations. With several bear species now listed under Convention on International Trade in Endangered Species of Wild Fauna and Flora as threatened with extinction and with bear farming being actively campaigned against on ethical grounds, it is important to seek and promote alternatives to the use of bear bile as medicine. This chapter describes and evaluates the scientific data relating to the efficacy of bear bile and potential alternatives to its use, including the use of bile from other animal species, the use of synthetic chemical alternatives, and the use of herbal substitutes. Scientific studies have confirmed the efficacy of bear bile as an antiinflammatory and a hepatoprotective agent. Ursodeoxycholic acid (UDCA), the active component of bear bile is used in a synthetic form in Western medicine and can serve as an alternative to bear bile in the treatment and management of certain cholestatic liver conditions. In TCM practice, bile from domesticated animal species (such as cattle, chicken, and pig) has been used as a substitute for bear bile. Following evaluation of TCM literature and pharmacological/clinical data, the authors propose six plant species, either as single herbs or in combination, Gardenia jasminoides (zhī zi; ), Scutellaria baicalensis (huáng qín; ), Coptis chinensis (huáng lián, ), Phellodendron amurense (huáng băi; ), Andrographis paniculata (chuan xin lian; ), and Rheum palmatum (dà huang; ), two medicinal Kampo formulations, Orengedokuto, Dia-Orengedokuto (which originated from traditional Chinese herbal formula Huanglian Jiedu Tang, ), and two individual phytochemicals (berberine and andrographolide) as

Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review.

PubMed

Tonob, Dunia; Melby, Melissa K

2017-05-01

Complementary and alternative medicine (CAM) is widely used for menopause, although not all women disclose use to their healthcare providers. This narrative review aims to expand providers' understanding of cross-cultural approaches to treating and managing menopause by providing an overarching framework and perspective on CAM treatments. Increased provider understanding and awareness may improve not only provider-patient communication but also effectiveness of treatments. The distinction between illness (what patients suffer) and disease (what physicians treat) highlights the gap between what patients seek and doctors provide, and may help clarify why many women seek CAM at menopause. For example, CAM is often sought by women for whom biomedicine has been unsuccessful or inaccessible. We review the relevance to menopause of three CAM categories: natural products, mind-body practices including meditation, and other complementary health approaches including traditional Chinese medicine (TCM) and Japanese Kampo. Assessing the effectiveness of CAM is challenging because of the individualized nature of illness patterns and associated treatments, which complicate the design of randomized controlled trials. Because many women seek CAM due to inefficacy of biomedical treatments, or cultural or economic marginalization, biomedical practitioners who make an effort to learn about CAM and ask patients about their CAM use or interest may dramatically improve the patient-provider relationship and rapport, as well as harnessing the 'meaning response' (Moerman, 2002) imbued in the clinical encounter. By working with women to integrate their CAM-related health-seeking behaviors and treatments, providers may also boost the efficacy of their own biomedical treatments. Copyright © 2017 Elsevier B.V. All rights reserved.

27 CFR 9.25 - San Pasqual Valley.

Code of Federal Regulations, 2012 CFR

2012-04-01

.... They are entitled: (1) “Escondido Quadrangle, California—San Diego County”, 7.5 minute series; (2) “San Pasqual Quadrangle, California—San Diego County”, 7.5 minute series; (3) “Valley Center Quadrangle, California—San Diego County”, 7.5 minute series. (c) Boundaries. The San Pasqual Valley viticultural area is...

27 CFR 9.25 - San Pasqual Valley.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... They are entitled: (1) “Escondido Quadrangle, California—San Diego County”, 7.5 minute series; (2) “San Pasqual Quadrangle, California—San Diego County”, 7.5 minute series; (3) “Valley Center Quadrangle, California—San Diego County”, 7.5 minute series. (c) Boundaries. The San Pasqual Valley viticultural area is...

27 CFR 9.25 - San Pasqual Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... They are entitled: (1) “Escondido Quadrangle, California—San Diego County”, 7.5 minute series; (2) “San Pasqual Quadrangle, California—San Diego County”, 7.5 minute series; (3) “Valley Center Quadrangle, California—San Diego County”, 7.5 minute series. (c) Boundaries. The San Pasqual Valley viticultural area is...

27 CFR 9.25 - San Pasqual Valley.

Code of Federal Regulations, 2014 CFR

2014-04-01

.... They are entitled: (1) “Escondido Quadrangle, California—San Diego County”, 7.5 minute series; (2) “San Pasqual Quadrangle, California—San Diego County”, 7.5 minute series; (3) “Valley Center Quadrangle, California—San Diego County”, 7.5 minute series. (c) Boundaries. The San Pasqual Valley viticultural area is...

27 CFR 9.25 - San Pasqual Valley.

Code of Federal Regulations, 2013 CFR

2013-04-01

.... They are entitled: (1) “Escondido Quadrangle, California—San Diego County”, 7.5 minute series; (2) “San Pasqual Quadrangle, California—San Diego County”, 7.5 minute series; (3) “Valley Center Quadrangle, California—San Diego County”, 7.5 minute series. (c) Boundaries. The San Pasqual Valley viticultural area is...

77 FR 46115 - Notice of Inventory Completion: San Diego Museum of Man, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

... Museum of Man professional staff in consultation with representatives of the Pueblo of Santa Ana, New... Inventory Completion: San Diego Museum of Man, San Diego, CA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The San Diego Museum of Man has completed an inventory of human remains in consultation...

Therapeutic efficacy of traditional Chinese medicine, Shen-Mai San, in cancer patients undergoing chemotherapy or radiotherapy: study protocol for a randomized, double-blind, placebo-controlled trial

PubMed Central

2012-01-01

Background Cancer is one of the major health issues worldwide. An increasing number of cancer patients are offered treatment with surgery, chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) is one of the most common complementary therapies offered to cancer patients in Taiwan. We designed a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy of TCM in patients with cancer. Methods/design In this study, inclusion criteria are postoperative patients with histologically confirmed cancer within 3 years who are undergoing chemotherapy or radiotherapy, more than 18 years old, have given signed informed consent, have the ability to read Chinese, and the ability for oral intake. Exclusion criteria include being pregnant, breast feeding, having completed chemotherapy or radiotherapy, brain metastasis with Eastern Cooperative Oncology Group (ECOG) performance status of two to four, delusion or hallucinations, acute infection, and have received medications under other clinical trials. The patients were separated into an intervention group (Shen-Mai-San, SMS) and a placebo group for four weeks using a randomized, double-blind procedure. The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life questionnaire (QOL-C30) was used to evaluate the quality of life. General data, hemoglobin (Hb), hematocrit (Hct), glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine, carcinoembryonic antigen (CEA), TCM diagnosis data and heart rate variability (HRV) were also recorded. These data were collected at baseline, two weeks and four weeks after receiving medication. The patients were prescribed granules which contained therapeutic medicines or placebo. Paired-T test was used for statistical analysis. Discussion Shen-Mai-San is composed of processed Ginseng radis, Liriope spicata, and Schizandrae fructus. It was found to be effective for treating cancer

75 FR 17329 - Safety Zone; Big Bay Fourth of July Fireworks, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

...-AA00 Safety Zone; Big Bay Fourth of July Fireworks, San Diego Bay, San Diego, CA AGENCY: Coast Guard... safety zone on the navigable waters of the San Diego Bay in support of the Big Bay July Fourth Show to Benefit the San Diego Armed Services YMCA. This temporary safety zone is necessary to provide for the...

Sediment conditions in the San Antonio River Basin downstream from San Antonio, Texas, 2000-13

USGS Publications Warehouse

Ockerman, Darwin J.; Banta, J. Ryan; Crow, Cassi L.; Opsahl, Stephen P.

2015-01-01

Sediment plays an important role in the ecological health of rivers and estuaries and consequently is an important issue for water-resource managers. To better understand sediment characteristics in the San Antonio River Basin, the U.S. Geological Survey, in cooperation with the San Antonio River Authority, completed a two-part study in the San Antonio River Basin downstream from San Antonio, Texas, to (1) collect and analyze sediment data to characterize sediment conditions and (2) develop and calibrate a watershed model to simulate hydrologic conditions and suspended-sediment loads during 2000–12.

San Mateo Creek Basin

EPA Pesticide Factsheets

The San Mateo Creek Basin comprises approximately 321 square miles within the Rio San Jose drainage basin in McKinley and Cibola counties, New Mexico. This basin is located within the Grants Mining District (GMD).

77 FR 42638 - Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... 1625-AA00 Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA AGENCY: Coast Guard... navigable waters of Mission Bay in support of the Sea World San Diego Fireworks. This safety zone is..., since immediate action is needed to ensure the public's safety. B. Basis and Purpose Sea World is...

78 FR 77597 - Safety Zone; Allied PRA-Solid Works, San Diego Bay; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

...-AA00 Safety Zone; Allied PRA-Solid Works, San Diego Bay; San Diego, CA AGENCY: Coast Guard, DHS. ACTION... the Allied PRA--Solid Works fireworks display, which will be conducted from a barge located southwest... Works; San Diego, CA. (a) Location. The limits of the safety zone will include all the navigable waters...

78 FR 29025 - Sea World San Diego Fireworks 2013 Season; Mission Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

...-AA00 Sea World San Diego Fireworks 2013 Season; Mission Bay, San Diego, CA AGENCY: Coast Guard, DHS... waters of Mission Bay in support of the Sea World San Diego Fireworks 2013 season. This safety zone is... Guard to establish safety zones (33 U.S.C 1221 et seq.). Sea World is sponsoring the Sea World Fireworks...

77 FR 60899 - Safety Zone; Sea World San Diego Fireworks, Mission Bay; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

... 1625-AA00 Safety Zone; Sea World San Diego Fireworks, Mission Bay; San Diego, CA AGENCY: Coast Guard... navigable waters of Mission Bay in support of the Sea World San Diego Fireworks. This safety zone is... zones (33 U.S.C 1221 et seq.). Sea World is sponsoring the Sea World Fireworks, which will include a...

Description of gravity cores from San Pablo Bay and Carquinez Strait, San Francisco Bay, California

USGS Publications Warehouse

Woodrow, Donald L.; John L. Chin,; Wong, Florence L.; Fregoso, Theresa A.; Jaffe, Bruce E.

2017-06-27

Seventy-two gravity cores were collected by the U.S. Geological Survey in 1990, 1991, and 2000 from San Pablo Bay and Carquinez Strait, California. The gravity cores collected within San Pablo Bay contain bioturbated laminated silts and sandy clays, whole and broken bivalve shells (mostly mussels), fossil tube structures, and fine-grained plant or wood fragments. Gravity cores from the channel wall of Carquinez Strait east of San Pablo Bay consist of sand and clay layers, whole and broken bivalve shells (less than in San Pablo Bay), trace fossil tubes, and minute fragments of plant material.

When falsified medicines enter the supply chain: description of an incident in Kenya and lessons learned for rapid response.

PubMed

Cohn, Jennifer; von Schoen-Angerer, Tido; Jambert, Elodie; Arreghini, Guido; Childs, Michelle

2013-01-01

Falsified and substandard medicines present serious concerns for public health. We describe an event that occurred in late 2011 involving falsified antiretroviral medicines found in the supplies of Médecins Sans Frontières (MSF) projects in Kenya. We discuss factors contributing to these falsified medicines entering the supply chain as well as the response by MSF and others. We make recommendations to help defend against future episodes of entry of falsified medicines into the supply chain as well as comments on appropriate responses in cases of falsified medicines.

Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

PubMed

Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

2010-01-15

Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae.

Comparison of the Benefit Feeling Rate Based on the Sho of OTC Kakkonto, Cold Remedy and Cold Remedy with Kakkonto Combination Product.

PubMed

Okita, Mitsuyoshi; Yayoshi, Yuki; Ohara, Kousuke; Negishi, Akio; Akimoto, Hayato; Inoue, Naoko; Numajiri, Sachihiko; Ohshima, Shigeru; Honma, Seiichi; Oshima, Shinji; Kobayashi, Daisuke

2017-10-01

Kakkonto (KK), a traditional Japanese Kampo formulation for cold and flu, is generally sold as an OTC pharmaceuticals used for self-medication. Kampo formulations should be used according to the Sho-symptoms of Kampo medicine. These symptoms refer to the subjective symptoms themselves. Although with OTC pharmaceuticals, this is often not the case. We surveyed the relationship of agreement of Sho with the benefit feeling rate (BFR) of patients who took KK (n=555), cold remedies with KK (CK, n=315), and general cold remedies (GC, n=539) using internet research. BFR of a faster recovery was greater in participants who took the medication early and who had confidence in their physical strength in all treatment groups. BFR was significantly higher in the GC group than in the KK group for patients with headache, runny nose, blocked nose, sneezing, and cough. BFR was also significantly higher in the GC group than in the CK group for headache (males) and cough (females). BFR was the highest in the KK group for stiff shoulders. All cold remedies were more effective when taken early, and the larger the number of Sho that a patient had, the greater the BFR increased. Therefore, a cold remedy is expected to be most effective when there are many cold symptoms and when it is taken at an early stage of the common cold.

77 FR 54815 - Safety Zone: America's Cup World Series Regattas, San Francisco Bay; San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

...-AA00 Safety Zone: America's Cup World Series Regattas, San Francisco Bay; San Francisco, CA AGENCY... the on-water activities associated with 2012 America's Cup World Series regattas scheduled for October..., the City of San Francisco plans to host two America's Cup World Series regattas as part of a circuit...

75 FR 15611 - Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

...-AA00 Safety Zone; United Portuguese SES Centennial Festa, San Diego Bay, San Diego, CA AGENCY: Coast... navigable waters of the San Diego Bay in support of the United Portuguese SES Centennial Festa. This... Centennial Festa, which will include a fireworks presentation originating from a tug and barge combination in...

Xiao-Yao-San, a Chinese Medicine Formula, Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat

PubMed Central

Sun, Hao-Yu; Li, Quan; Liu, Yu-Ying; Wei, Xiao-Hong; Pan, Chun-Shui; Fan, Jing-Yu; Han, Jing-Yan

2017-01-01

Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with. The present study investigated the effect of Xiao-Yao-San (XYS), a traditional Chinese medicine formula used for treatment of gynecological disease, on the chronic stress-induced polycystic ovary and its underlying mechanism. Female Sprague-Dwaley rats underwent a 3 weeks chronic unpredictable mild stress (CUMS) procedure to establish the PCOS model, followed by 4 weeks treatment with XYS (0.505 g/kg or 1.01 g/kg) by gavage. Granulosa cells were exposed to noradrenaline (1 mM) in vitro for 24 h, followed by incubation with or without XYS-treated rat serum for 24 h. Post-treatment with XYS ameliorated CUMS-induced irregular estrous cycles and follicles development abnormalities, decrease of estradiol and progesterone level as well as increase of luteinizing hormone in serum, reduced cystic follicles formation and the apoptosis and autophagy of granulosa cells, attenuated the increase in dopamine beta hydroxylase and c-fos level in locus coeruleus, the noradrenaline level in serum and ovarian tissue, and the expression of beta 2 adrenergic receptor in ovarian tissue. Besides, XYS alleviated the reduction of phosphorylation of ribosomal protein S6 kinase polypeptide I and protein kinase B, as well as the increase of microtubule-associated protein light chain 3-I to microtubule-associated protein light chain 3-II conversion both in vivo and in vitro. This study demonstrated XYS as a potential strategy for CUMS induced polycystic ovary, and suggested that the beneficial role of XYS was correlated with the regulation of the sympathetic nerve activity. PMID:29018356

33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. 165.1187 Section 165.1187... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. (a) Location. All waters extending...

33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. 165.1187 Section 165.1187... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. (a) Location. All waters extending...

The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis

PubMed Central

Zhang, Xiao-na; Ma, Ze-jun; Wang, Ying; Li, Yu-zhu; Sun, Bei; Guo, Xin; Pan, Cong-qing; Chen, Li-ming

2016-01-01

Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments. Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing. In this study, we explored the effect of TLXDS on healing of diabetic wounds and investigated underlying mechanisms. Four weeks after intravenous injection of streptozotocin, two full-thickness excisional wounds were created with a 10 mm diameter sterile biopsy punch on the back of rats. The ethanol extract of TLXDS was given once daily by oral gavage. Wound area, histological change, inflammation, angiogenesis, and collagen synthesis were evaluated. TLXDS treatment significantly accelerated healing of diabetic rats and improved the healing quality. These effects were associated with reduced neutrophil infiltration and macrophage accumulation, enhanced angiogenesis, and increased collagen deposition. This study shows that TLXDS improves diabetes-impaired wound healing. PMID:27057551

33 CFR 165.1102 - Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; Naval Base Point... Guard District § 165.1102 Security Zone; Naval Base Point Loma; San Diego Bay, San Diego, CA. (a) Location. The following area is a security zone: The water adjacent to the Naval Base Point Loma, San Diego...

Space Radar Image of San Francisco, California

NASA Image and Video Library

1999-04-15

This image of San Francisco, California shows how the radar distinguishes between densely populated urban areas and nearby areas that are relatively unsettled. Downtown San Francisco is at the center and the city of Oakland is at the right across the San Francisco Bay. Some city areas, such as the South of Market, called the SOMA district in San Francisco, appear bright red due to the alignment of streets and buildings to the incoming radar beam. Various bridges in the area are also visible including the Golden Gate Bridge (left center) at the opening of San Francisco Bay, the Bay Bridge (right center) connecting San Francisco and Oakland, and the San Mateo Bridge (bottom center). All the dark areas on the image are relatively smooth water: the Pacific Ocean to the left, San Francisco Bay in the center, and various reservoirs. Two major faults bounding the San Francisco-Oakland urban areas are visible on this image. The San Andreas fault, on the San Francisco peninsula, is seen in the lower left of the image. The fault trace is the straight feature filled with linear reservoirs which appear dark. The Hayward fault is the straight feature on the right side of the image between the urban areas and the hillier terrain to the east. The image is about 42 kilometers by 58 kilometers (26 miles by 36 miles) with north toward the upper right. This area is centered at 37.83 degrees north latitude, 122.38 degrees east longitude. http://photojournal.jpl.nasa.gov/catalog/PIA01791

Modulation of Pacemaker Potentials in Murine Small Intestinal Interstitial Cells of Cajal by Gamisoyo-San, a Traditional Chinese Herbal Medicine.

PubMed

Kim, Doeun; Kim, Jung Nam; Nam, Joo Hyun; Lee, Jong Rok; Kim, Sang Chan; Kim, Byung Joo

2018-04-19

The Gamisoyo-san (GSS) has been used for -improving the gastrointestinal (GI) symptoms. The purpose of this study was to investigate the effects of GSS, a traditional Chinese herbal medicine, on the pacemaker potentials of mouse small intestinal interstitial cells of Cajal (ICCs). ICCs from the small intestines were dissociated and cultured. Whole-cell patch-clamp configuration was used to record pacemaker potentials and membrane currents. GSS depolarized ICC pacemaker potentials in a dose-dependent manner. Pretreatment with 4-diphenylacetoxypiperidinium iodide completely inhibited GSS-induced pacemaker potential depolarizations. Intracellular GDP-β-S inhibited GSS-induced effects, and in the presence of U-73122, GSS-induced effects were inhibited. Also, GSS in the presence of a Ca2+-free solution or thapsigargin did not depolarize pacemaker potentials. However, in the presence of calphostin C, GSS slightly depolarized pacemaker potentials. Furthermore, GSS inhibited both transient receptor potential melastatin7 and Ca2+-activated Cl- channel (anoctamin1) currents. GSS depolarized pacemaker potentials of ICCs via G protein and muscarinic M3 receptor signaling pathways and through internal or external Ca2+-, phospholipase C-, and protein kinase C-dependent and transient receptor potential melastatin 7-, and anoctamin 1-independent pathways. The study shows that GSS may regulate GI tract motility, suggesting that GSS could be a basis for developing novel prokinetic agents for treating GI motility dysfunctions. © 2018 S. Karger AG, Basel.

75 FR 35651 - Safety Zone; San Francisco Chronicle Fireworks Display, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG 2010-0367] Safety Zone; San Francisco Chronicle Fireworks Display, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the Independence Day...

Una Visita al Viejo San Juan (A Visit to Old San Juan).

ERIC Educational Resources Information Center

Cabello, Victor; And Others

Written in Spanish, this black and white illustrated booklet provides a tour of Old San Juan, Puerto Rico's oldest and most historic city. Brief historical information is provided on the Perro de San Jeronimo, a statue of a barking dog found in front of the Castillo; Plaza de Colon, a small plaza dedicated to Christopher Columbus; the Catedral de…

Chinese herbal medicine, sibship, and blood lead in children.

PubMed

Cheng, T J; Wong, R H; Lin, Y P; Hwang, Y H; Horng, J J; Wang, J D

1998-08-01

Risk factors for increased blood lead concentration (BPb) has been investigated. However, the effect of sibship and Chinese herbal medicine on BPb has not been systematically studied. In this study BPb data from voluntary testing was used to determine if Chinese herbal medicine and sibship were associated with BPb. 319 children aged 1-7 were tested for BPb. Meanwhile, parents were interviewed to obtain information including consumption of Chinese herbal medicine, living environment, lifestyle, and sibship of the children tested. The mean (SD) BPb of 319 preschool children was 4.4 (2.4) micrograms/dl. The consumption of Ba-baw-san (a Chinese herbal medicine) was significantly associated with increased BPb in children (p = 0.038). Further multivariate regression analysis of BPb in 50 pairs of siblings showed the factors of being brothers explained 75% of variation for BPb, and being sisters and brother-sister explained 51% and 41% of variation respectively. Chinese herbal medicine and children's play patterns within the family expressed in different types of sibship are the main determinants of low concentrations of BPb in preschool children of Taiwan.

Dipping San Andreas and Hayward faults revealed beneath San Francisco Bay, California

USGS Publications Warehouse

Parsons, T.; Hart, P.E.

1999-01-01

The San Francisco Bay area is crossed by several right-lateral strike-slip faults of the San Andreas fault zone. Fault-plane reflections reveal that two of these faults, the San Andreas and Hayward, dip toward each other below seismogenic depths at 60?? and 70??, respectively, and persist to the base of the crust. Previously, a horizontal detachment linking the two faults in the lower crust beneath San Francisco Bay was proposed. The only near-vertical-incidence reflection data available prior to the most recent experiment in 1997 were recorded parallel to the major fault structures. When the new reflection data recorded orthogonal to the faults are compared with the older data, the highest, amplitude reflections show clear variations in moveout with recording azimuth. In addition, reflection times consistently increase with distance from the faults. If the reflectors were horizontal, reflection moveout would be independent of azimuth, and reflection times would be independent of distance from the faults. The best-fit solution from three-dimensional traveltime modeling is a pair of high-angle dipping surfaces. The close correspondence of these dipping structures with the San Andreas and Hayward faults leads us to conclude that they are the faults beneath seismogenic depths. If the faults retain their observed dips, they would converge into a single zone in the upper mantle -45 km beneath the surface, although we can only observe them in the crust.

ASTER Images San Francisco Bay Area

NASA Image and Video Library

2000-04-26

This image of the San Francisco Bay region was acquired on March 3, 2000 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters about 50 to 300 feet ), ASTER will image Earth for the next 6 years to map and monitor the changing surface of our planet. Image: This image covers an area 60 kilometers (37 miles) wide and 75 kilometers (47 miles) long in three bands of the reflected visible and infrared wavelength region. The combination of bands portrays vegetation in red, and urban areas in gray. Sediment in the Suisun Bay, San Pablo Bay, San Francisco Bay, and the Pacific Ocean shows up as lighter shades of blue. Along the west coast of the San Francisco Peninsula, strong surf can be seen as a white fringe along the shoreline. A powerful rip tide is visible extending westward from Daly City into the Pacific Ocean. In the lower right corner, the wetlands of the South San Francisco Bay National Wildlife Refuge appear as large dark blue and brown polygons. The high spatial resolution of ASTER allows fine detail to be observed in the scene. The main bridges of the area (San Mateo, San Francisco-Oakland Bay, Golden Gate, Richmond-San Rafael, Benicia-Martinez, and Carquinez) are easily picked out, connecting the different communities in the Bay area. Shadows of the towers along the Bay Bridge can be seen over the adjacent bay water. With enlargement the entire road network can be easily mapped; individual buildings are visible, including the shadows of the high-rises in downtown San Francisco. Inset: This enlargement of the San Francisco Airport highlights the high spatial resolution of ASTER. With further enlargement and careful examination, airplanes can be seen at the terminals. http://photojournal.jpl.nasa.gov/catalog/PIA02606

San Cristobal Volcano, Nicaragua

NASA Technical Reports Server (NTRS)

1990-01-01

A white plume of smoke, from San Cristobal Volcano (13.0N, 87.5W) on the western coast of Nicaragua, blows westward along the Nicaraguan coast just south of the Gulf of Fonseca and the Honduran border. San Csistobal is a strato volcano some 1,745 meters high and is frequently active.

San Marco C-2 (San Marco-4) Post Launch Report No. 1

NASA Technical Reports Server (NTRS)

1974-01-01

The San Marco C-2 spacecraft, now designated San Marco-4, was successfully launched by a Scout vehicle from the San Marco Platform on 18 February 1974 at 6:05 a.m. EDT. The launch occurred 2 hours 50 minutes into the 3-hour window due co low cloud cover at the launch site. All spacecraft subsystems have been checked and are functioning normally. The protective caps for the two U.S. experiments were ejected and the Omegatron experiment activated on 19 February. The neutral mass spectrometer was activated as scheduled on 22 February after sufficient time to allow for spacecraft outgassing and to avoid the possibility of corona occurring. Both instruments are performing properly and worthwhile scientific data is being acquired.

78 FR 19103 - Safety Zone; Spanish Navy School Ship San Sebastian El Cano Escort; Bahia de San Juan; San Juan, PR

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

... School Ship San Sebastian El Cano, a public vessel, and during their 21 gun salute in accordance with the... zone is necessary to protect the public from the hazards associated with the 21 gun salute near the Bar... an escort of the Spanish Navy School Ship San Sebastian El Cano and 21 gun salute. The outbound...

78 FR 53245 - Safety Zone; San Diego Bayfair; Mission Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

..., Protection of Children from Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health or risk to safety that may...-AA00 Safety Zone; San Diego Bayfair; Mission Bay, San Diego, CA AGENCY: Coast Guard, DHS. ACTION...

Space Radar Image of San Francisco, California

NASA Technical Reports Server (NTRS)

1994-01-01

This image of San Francisco, California shows how the radar distinguishes between densely populated urban areas and nearby areas that are relatively unsettled. Downtown San Francisco is at the center and the city of Oakland is at the right across the San Francisco Bay. Some city areas, such as the South of Market, called the SOMA district in San Francisco, appear bright red due to the alignment of streets and buildings to the incoming radar beam. Various bridges in the area are also visible including the Golden Gate Bridge (left center) at the opening of San Francisco Bay, the Bay Bridge (right center) connecting San Francisco and Oakland, and the San Mateo Bridge (bottom center). All the dark areas on the image are relatively smooth water: the Pacific Ocean to the left, San Francisco Bay in the center, and various reservoirs. Two major faults bounding the San Francisco-Oakland urban areas are visible on this image. The San Andreas fault, on the San Francisco peninsula, is seen in the lower left of the image. The fault trace is the straight feature filled with linear reservoirs which appear dark. The Hayward fault is the straight feature on the right side of the image between the urban areas and the hillier terrain to the east. The image is about 42 kilometers by 58 kilometers (26 miles by 36 miles) with north toward the upper right. This area is centered at 37.83 degrees north latitude, 122.38 degrees east longitude. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) imaging radar when it flew aboard the space shuttle Endeavour on October 3, 1994. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth.

Education, collaboration, and innovation: intelligent biology and medicine in the era of big data.

PubMed

Ruan, Jianhua; Jin, Victor; Huang, Yufei; Xu, Hua; Edwards, Jeremy S; Chen, Yidong; Zhao, Zhongming

2015-01-01

Here we present a summary of the 2014 International Conference on Intelligent Biology and Medicine (ICIBM 2014) and the editorial report of the supplement to BMC Genomics and BMC Systems Biology that includes 20 research articles selected from ICIBM 2014. The conference was held on December 4-6, 2014 at San Antonio, Texas, USA, and included six scientific sessions, four tutorials, four keynote presentations, nine highlight talks, and a poster session that covered cutting-edge research in bioinformatics, systems biology, and computational medicine.

p38 MAPK signal pathway involved in anti-inflammatory effect of Chaihu-Shugan-San and Shen-ling-bai-zhu-San on hepatocyte in non-alcoholic steatohepatitis rats.

PubMed

Yang, QinHe; Xu, YongJian; Feng, GaoFei; Hu, ChaoFeng; Zhang, YuPei; Cheng, ShaoBing; Wang, YanPing; Gong, XiangWen

2014-01-01

Traditional Chinese Medicine (TCM), has over thousands-of-years history of use. Chaihu-Shugan-San (CSS), and Shen-ling-bai-zhu-San (SLBZS), are famous traditional Chinese herbal medicine formulas, which have been used in China, for the treatment of many chronic diseases. This study investigated the anti-inflammatory effects of CSS and SLBZS on signaling molecules involved in p38 mitogen-activated protein kinase (p38 MAPK), pathway on hepatocytes of non-alcoholic steatohepatitis (NASH), rats induced by high fat diet. SD male rats were randomly divided into 8 groups: negative control group, model control group, high (9.6g/kg/day)/low (3.2g/kg/day)-dose CSS group, high (30g/kg/day)/low (10g/kg/day)-dose SLBZS group, high (39.6g/kg/day)/low (13.2g/kg/day)-dose integrated group. The rats of NASH model were induced by feeding a high-fat diet. After 16, wks, Hepatocytes were isolated from 6, rats in each group by collagenase perfusion. The liver histopathological changes and serum inflammatory cytokines TNF-α, IL-6 were determined. The proteins of TLR4, phosphor-p38 MAPK and p38 MAPK involved in p38 MAPK signal pathway were assayed. The statistical data indicated the NASH model rats reproduced typical histopathological features of NASH in human. CSS and SLBZS ameliorated lipid metabolic disturbance, attenuated NASH progression, decreased the levels of TNF-α and IL-6 in serum, as well as inhibited TLR4 protein expression, p38 MAPK phosphorylation, and activation of p38 MAPK. In conclusion, CSS and SLBZS might work as a significant anti-inflammatory effect on hepatocyte of NASH by inhibiting the activation of TLR4, p-p38 MAPK and p38 MAPK involved in p38 MAPK signal pathway. To some extent, CSS and SLBZS may be a potential alternative and complementary medicine to protect against liver injury, alleviate the inflammation reaction, moderate NASH progression.

San Francisco, San Pablo Bay Area

NASA Image and Video Library

1994-09-30

STS068-244-022 (30 September-11 October 1994) --- (San Francisco, San Pablo Bay Area) Photographed through the Space Shuttle Endeavour's flight deck windows, the heavily populated bay area is featured in this 70mm frame. The relatively low altitude of Endeavour's orbit (115 nautical miles) and the use of a 250mm lens on the Hasselblad camera allowed for capturing detail in features such as the Berkeley Marina (frame center). The region's topography is well depicted with the lowland areas heavily populated and the hills much more sparsely covered. The Oakland Hills in the right lower center appear to be re-vegetated after a devastating fire. The Golden Gate Recreation Area in the upper left also shows heavy vegetation. The three bridges across the main part of the bay and their connecting roads are prominent. Cultural features such as Golden Gate Park and the Presidio contrast with the gray of the city.

33 CFR 3.55-20 - Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. 3.55-20 Section 3.55-20 Navigation and... Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. The Sector San Francisco...

33 CFR 3.55-20 - Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. 3.55-20 Section 3.55-20 Navigation and... Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. The Sector San Francisco...

33 CFR 3.55-20 - Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. 3.55-20 Section 3.55-20 Navigation and... Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. The Sector San Francisco...

33 CFR 3.55-20 - Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. 3.55-20 Section 3.55-20 Navigation and... Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. The Sector San Francisco...

33 CFR 3.55-20 - Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Sector San Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. 3.55-20 Section 3.55-20 Navigation and... Francisco: San Francisco Bay Marine Inspection Zone and Captain of the Port Zone. The Sector San Francisco...

The San Andreas Fault in the San Francisco Bay area, California: a geology fieldtrip guidebook to selected stops on public lands

USGS Publications Warehouse

Stoffer, Philip W.

2005-01-01

This guidebook contains a series of geology fieldtrips with selected destinations along the San Andreas Fault in part of the region that experienced surface rupture during the Great San Francisco Earthquake of 1906. Introductory materials present general information about the San Andreas Fault System, landscape features, and ecological factors associated with faults in the South Bay, Santa Cruz Mountains, the San Francisco Peninsula, and the Point Reyes National Seashore regions. Trip stops include roadside areas and recommended hikes along regional faults and to nearby geologic and landscape features that provide opportunities to make casual observations about the geologic history and landscape evolution. Destinations include the sites along the San Andreas and Calaveras faults in the San Juan Bautista and Hollister region. Stops on public land along the San Andreas Fault in the Santa Cruz Mountains in Santa Clara and Santa Cruz counties include in the Loma Prieta summit area, Forest of Nicene Marks State Park, Lexington County Park, Sanborn County Park, Castle Rock State Park, and the Mid Peninsula Open Space Preserve. Destinations on the San Francisco Peninsula and along the coast in San Mateo County include the Crystal Springs Reservoir area, Mussel Rock Park, and parts of Golden Gate National Recreation Area, with additional stops associated with the San Gregorio Fault system at Montara State Beach, the James F. Fitzgerald Preserve, and at Half Moon Bay. Field trip destinations in the Point Reyes National Seashore and vicinity provide information about geology and character of the San Andreas Fault system north of San Francisco.

Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer.

PubMed

Su, Zhi-Heng; Zou, Guo-An; Preiss, Alfred; Zhang, Hong-Wu; Zou, Zhong-Mei

2010-11-02

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression clinically. However, the chemical constituents in CSGS had not been studied so far. To quickly identify the chemical constituents of CSGS and to understand the chemical profiles related to antioxidant activity of CSGS, liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole orbitrap (LC-LTQ-Orbitrap) mass spectrometry has been applied for online identification of chemical constituents in complex system, meanwhile, antioxidant profile of CSGS was investigated by the fraction collecting and microplate reading system. As a result, 33 chemical constituents in CSGS were identified. Among them, 13 components could be detected both in positive and in negative ion modes, 20 constituents were determined only in positive ion mode and 2 components were only detected in negative ion mode. Meanwhile, the potential antioxidant profile of CSGS was also characterized by combination of 96-well plate collection of elutes from HPLC analysis and microplate spectrophotometer, in which the scavenging activities of free radical produced by DPPH of each fraction could be directly investigated by the analysis of microplate reader. This study quickly screened the contribution of CSGS fractions to the antioxidant activity and online identified the corresponding active constituents. The results indicated that the combination of LC-MS(n) and 96-well plate assay system established in this paper would be a useful strategy for correlating the chemical profile of TCMs with their bioactivities without isolation and purification. Crown Copyright (c) 2010. Published by Elsevier B.V. All rights reserved.

Minority faculty voices on diversity in academic medicine: perspectives from one school.

PubMed

Mahoney, Megan R; Wilson, Elisabeth; Odom, Kara L; Flowers, Loma; Adler, Shelley R

2008-08-01

To examine the perceptions and experiences of ethnic minority faculty at University of California-San Francisco regarding racial and ethnic diversity in academic medicine, in light of a constitutional measure outlawing race- and gender-based affirmative action programs by public universities in California. In 2005, underrepresented minority faculty in the School of Medicine at University of California-San Francisco were individually interviewed to explore three topics: participants' experiences as minorities, perspectives on diversity and discrimination in academic medicine, and recommendations for improvement. Interviews were tape-recorded, transcribed verbatim, and subsequently coded using principles of qualitative, text-based analysis in a four-stage review process. Thirty-six minority faculty (15 assistant professors, 11 associate professors, and 10 full professors) participated, representing diversity across specialties, faculty rank, gender, and race/ethnicity. Seventeen were African American, 16 were Latino, and 3 were Asian. Twenty participants were women. Investigators identified four major themes: (1) choosing to participate in diversity-related activities, driven by personal commitment and institutional pressure, (2) the gap between intention and implementation of institutional efforts to increase diversity, (3) detecting and reacting to discrimination, and (4) a need for a multifaceted approach to mentorship, given few available minority mentors. Minority faculty are an excellent resource for identifying strategies to improve diversity in academic medicine. Participants emphasized the strong association between effective mentorship and career satisfaction, and many delineated unique mentoring needs of minority faculty that persist throughout academic ranks. Findings have direct application to future institutional policies in recruitment and retention of underrepresented minority faculty.

Minority Faculty Voices on Diversity in Academic Medicine: Perspectives From One School

PubMed Central

Mahoney, Megan R.; Wilson, Elisabeth; Odom, Kara L.; Flowers, Loma; Adler, Shelley R.

2010-01-01

Purpose To examine the perceptions and experiences of ethnic minority faculty at University of California–San Francisco regarding racial and ethnic diversity in academic medicine, in light of a constitutional measure outlawing race- and gender-based affirmative action programs by public universities in California. Method In 2005, underrepresented minority faculty in the School of Medicine at University of California–San Francisco were individually interviewed to explore three topics: participants’ experiences as minorities, perspectives on diversity and discrimination in academic medicine, and recommendations for improvement. Interviews were tape-recorded, transcribed verbatim, and subsequently coded using principles of qualitative, text-based analysis in a four-stage review process. Results Thirty-six minority faculty (15 assistant professors, 11 associate professors, and 10 full professors) participated, representing diversity across specialties, faculty rank, gender, and race/ethnicity. Seventeen were African American, 16 were Latino, and 3 were Asian. Twenty participants were women. Investigators identified four major themes: (1) choosing to participate in diversity-related activities, driven by personal commitment and institutional pressure, (2) the gap between intention and implementation of institutional efforts to increase diversity, (3) detecting and reacting to discrimination, and (4) a need for a multifaceted approach to mentorship, given few available minority mentors. Conclusions Minority faculty are an excellent resource for identifying strategies to improve diversity in academic medicine. Participants emphasized the strong association between effective mentorship and career satisfaction, and many delineated unique mentoring needs of minority faculty that persist throughout academic ranks. Findings have direct application to future institutional policies in recruitment and retention of underrepresented minority faculty. PMID:18667896

Education, collaboration, and innovation: intelligent biology and medicine in the era of big data

PubMed Central

2015-01-01

Here we present a summary of the 2014 International Conference on Intelligent Biology and Medicine (ICIBM 2014) and the editorial report of the supplement to BMC Genomics and BMC Systems Biology that includes 20 research articles selected from ICIBM 2014. The conference was held on December 4-6, 2014 at San Antonio, Texas, USA, and included six scientific sessions, four tutorials, four keynote presentations, nine highlight talks, and a poster session that covered cutting-edge research in bioinformatics, systems biology, and computational medicine. PMID:26099197

[Risk factors for students desertion from the UASLP School of Medicine, México].

PubMed

Hernández-Mata, José María; Hernández-Castro, Rodrigo; Nieto-Caraveo, Amado; Hernández-Sierra, Juan Francisco

2005-01-01

To obtain the profile of students that deserted from the Faculty of Medicine of the Autonomous University of San Luis Potosi, México. Cases and controls nested in a cohort. All students that voluntarily deserted between 1992 and 2002 were consulted. Each student was compared in an aleatory form with a regular student and a proper questionnaire was applied. The significantly associated factors to abandon the Faculty of Medicine were: high school of origin (OR=2.43), extra-ordinary exam (OR=3.13), and lack of vocation (OR=2.41). The subjacent factors for not deserting from the Faculty of Medicine were: study habits, capacity for sustained effort, and tolerance to frustration.

English Articulation between the San Francisco Unified School District and the City College of San Francisco. Youth Data Archive Issue Brief

ERIC Educational Resources Information Center

Gurantz, Oded

2012-01-01

San Francisco's Bridge to Success (BtS) initiative brings together the City and County of San Francisco, the San Francisco Unified School District (SFUSD), the City College of San Francisco (CCSF), and key community organizations to promote postsecondary success for underrepresented students. Various working groups, each comprised of staff from…

78 FR 39610 - Safety Zone; Big Bay Boom, San Diego Bay; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

..., Protection of Children from Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health or risk to safety that may...-AA00 Safety Zone; Big Bay Boom, San Diego Bay; San Diego, CA AGENCY: Coast Guard, DHS. ACTION...

33 CFR 165.1103 - Security Zone; Naval Mine Anti Submarine Warfare Command; San Diego Bay, San Diego, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Submarine Warfare Command; San Diego Bay, San Diego, CA. 165.1103 Section 165.1103 Navigation and Navigable... Eleventh Coast Guard District § 165.1103 Security Zone; Naval Mine Anti Submarine Warfare Command; San... the Naval Mine Anti Submarine Warfare Command, bound by the following coordinates: 32°43′40.9″ N, 117...

Chinese Herbal Medicine and Depression: The Research Evidence

PubMed Central

Butler, Lee; Pilkington, Karen

2013-01-01

Background. Alternative approaches for managing depression are often sought and herbal mixtures are widely used in China. The aim of this paper was to provide an overall picture of the current evidence by analysing published systematic reviews and presenting a supplementary systematic review of trials in Western databases. Methods. Searches were conducted using AMED, Cochrane Library, EMBASE, MEDLINE/PubMed, PsycINFO, and trial registers. Results were screened and selected trials were evaluated by two reviewers working independently. Systematic reviews were identified and assessed using key criteria. Results. Five systematic reviews were located addressing the Chinese literature, adjunctive use of Chinese herbs, and the formulae Chaihu-Shugan-San, Xiao Yao San, and Free and Easy Wanderer Plus. The supplementary review located 8 trials, 3 of which were not included in previous reviews. Positive results were reported: no significant differences from medication, greater effect than medication or placebo, reduced adverse event rates when combined or compared with antidepressants. However, limitations in methodology and reporting were revealed. Conclusions. Despite promising results, particularly for Xiao Yao San and its modifications, the effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence. Further well-designed, well-reported trials that reflect practice may be worth pursuing. PMID:23476701

Chinese herbal medicine and depression: the research evidence.

PubMed

Butler, Lee; Pilkington, Karen

2013-01-01

Background. Alternative approaches for managing depression are often sought and herbal mixtures are widely used in China. The aim of this paper was to provide an overall picture of the current evidence by analysing published systematic reviews and presenting a supplementary systematic review of trials in Western databases. Methods. Searches were conducted using AMED, Cochrane Library, EMBASE, MEDLINE/PubMed, PsycINFO, and trial registers. Results were screened and selected trials were evaluated by two reviewers working independently. Systematic reviews were identified and assessed using key criteria. Results. Five systematic reviews were located addressing the Chinese literature, adjunctive use of Chinese herbs, and the formulae Chaihu-Shugan-San, Xiao Yao San, and Free and Easy Wanderer Plus. The supplementary review located 8 trials, 3 of which were not included in previous reviews. Positive results were reported: no significant differences from medication, greater effect than medication or placebo, reduced adverse event rates when combined or compared with antidepressants. However, limitations in methodology and reporting were revealed. Conclusions. Despite promising results, particularly for Xiao Yao San and its modifications, the effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence. Further well-designed, well-reported trials that reflect practice may be worth pursuing.

San Francisco and Bay Area, CA, USA

NASA Image and Video Library

1991-05-06

STS039-89-053 (28 April-6 May 1991) --- A 70mm, infrared frame of the city of San Francisco, taken on a clear day. The gray areas represent urban regions, and the red areas are vegetated. Within the city of San Francisco, parks like Golden Gate park and the Presidio at the base of the Golden Gate Bridge easily stand out from the well-developed parts of the city. Major thoroughfares and bridges (Golden Gate and Bay Bridges) are seen as are other landmarks such as Candlestick Park and Alcatraz. The trace of the San Andreas faults show as a straight valley running northerly along the San Francisco peninsula. Good detail is visible in the turbid waters of San Francisco Bay.

49. Aerial view of statehouse and San Cristobal, Fuerte El ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

49. Aerial view of statehouse and San Cristobal, Fuerte El Abanico, San Carlos ravelin and Atlantic Ocean in the background - Castillo de San Cristobal, Boulevard Norzagaray, San Juan, San Juan Municipio, PR

History of San Marco

NASA Technical Reports Server (NTRS)

Caporale, A. J.

1968-01-01

A brief history is reported of the first San Marco project, a joint program of the United States and Italy. The Project was a three phase effort to investigate upper air density and associated ionosphere phenomena. The initial phase included the design and development of the spacecraft, the experiments, the launch complex, and a series of suborbital flights, from Wallops Island. The second phase, consisting of designing, fabricating, and testing a spacecraft for the first orbital mission, culminated in an orbital launch also from Wallops Island. The third phase consisted of further refining the experiments and spacecraft instrumentation and of establishing a full-bore scout complex in Kenya. The launch of San Marco B, in April 1967, from this complex into an equatorial orbit, concluded the initial San Marco effort.

South entrance, plan, section, & detail. San Bernardino Valley Union ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

South entrance, plan, section, & detail. San Bernardino Valley Union Junior College, Science Building. Detailed drawings of tile work, wrought iron, and art stone, Howard E. Jones, Architect, San Bernardino, California. Sheet 6, job no. 311. Scale 1.2 inch to the foot. February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

Pleistocene Brawley and Ocotillo Formations: Evidence for initial strike-slip deformation along the San Felipe and San Jacinto fault zonez, Southern California

USGS Publications Warehouse

Kirby, S.M.; Janecke, S.U.; Dorsey, R.J.; Housen, B.A.; Langenheim, V.E.; McDougall, K.A.; Steeley, A.N.

2007-01-01

We examine the Pleistocene tectonic reorganization of the Pacific-North American plate boundary in the Salton Trough of southern California with an integrated approach that includes basin analysis, magnetostratigraphy, and geologic mapping of upper Pliocene to Pleistocene sedimentary rocks in the San Felipe Hills. These deposits preserve the earliest sedimentary record of movement on the San Felipe and San Jacinto fault zones that replaced and deactivated the late Cenozoic West Salton detachment fault. Sandstone and mudstone of the Brawley Formation accumulated between ???1.1 and ???0.6-0.5 Ma in a delta on the margin of an arid Pleistocene lake, which received sediment from alluvial fans of the Ocotillo Formation to the west-southwest. Our analysis indicates that the Ocotillo and Brawley formations prograded abruptly to the east-northeast across a former mud-dominated perennial lake (Borrego Formation) at ???1.1 Ma in response to initiation of the dextral-oblique San Felipe fault zone. The ???25-km-long San Felipe anticline initiated at about the same time and produced an intrabasinal basement-cored high within the San Felipe-Borrego basin that is recorded by progressive unconformities on its north and south limbs. A disconformity at the base of the Brawley Formation in the eastern San Felipe Hills probably records initiation and early blind slip at the southeast tip of the Clark strand of the San Jacinto fault zone. Our data are consistent with abrupt and nearly synchronous inception of the San Jacinto and San Felipe fault zones southwest of the southern San Andreas fault in the early Pleistocene during a pronounced southwestward broadening of the San Andreas fault zone. The current contractional geometry of the San Jacinto fault zone developed after ???0.5-0.6 Ma during a second, less significant change in structural style. ?? 2007 by The University of Chicago. All rights reserved.

33 CFR 165.T11-534 - Safety zone; Bay Bridge construction, San Francisco Bay, San Francisco, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Francisco, CA. (a) Location. This temporary safety zone is established in the navigable waters of the San... construction, San Francisco Bay, San Francisco, CA. 165.T11-534 Section 165.T11-534 Navigation and Navigable... within a box connected by the following points: 37°49′06″ N, 122°21′17″ W; 37°49′01″ N, 122°21′12″ W; 37...

The San Andreas fault in the San Francisco Bay region, California: Structure and kinematics of a Young plate boundary

USGS Publications Warehouse

Jachens, R.C.; Zoback, M.L.

1999-01-01

Recently acquired high-resolution aeromagnetic data delineate offset and/or truncated magnetic rock bodies of the Franciscan Complex that define the location and structure of, and total offset across, the San Andreas fault in the San Francisco Bay region. Two distinctive magnetic anomalies caused by ultramafic rocks and metabasalts east of, and truncated at, the San Andreas fault have clear counterparts west of the fault that indicate a total right-lateral offset of only 22 km on the Peninsula segment, the active strand that ruptured in 1906. The location of the Peninsula segment is well defined magnetically on the northern peninsula where it goes offshore, and can be traced along strike an additional ~6 km to the northwest. Just offshore from Lake Merced, the inferred fault trace steps right (northeast) 3 km onto a nearly parallel strand that can be traced magnetically northwest more than 20 km as the linear northeast edge of a magnetic block bounded by the San Andreas fault, the Pilarcitos fault, and the San Gregorio-Hosgri fault zone. This right-stepping strand, the Golden Gate segment, joins the eastern mapped trace of the San Andreas fault at Bolinas Lagoon and projects back onshore to the southeast near Lake Merced. Inversion of detailed gravity data on the San Francisco Peninsula reveals a 3 km wide basin situated between the two strands of the San Andreas fault, floored by Franciscan basement and filled with Plio-Quaternary sedimentary deposits of the Merced and Colma formations. The basin, ~1 km deep at the coast, narrows and becomes thinner to the southeast along the fault over a distance of ~12 km. The length, width, and location of the basin between the two strands are consistent with a pull-apart basin formed behind the right step in the right-lateral strike-slip San Andreas fault system and currently moving southeast with the North American plate. Slight nonparallelism of the two strands bounding the basin (implying a small component of convergence

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain.

PubMed

Ye, Xiaowei; Lu, Dongyan; Chen, Xinlin; Li, Suihui; Chen, Yao; Deng, Li

2016-06-01

Shuangbai San is a Chinese herb preparation used externally to treat pain. There have been few randomized controlled trials addressing the safety and usefulness of Shuangbai San, such as its effect on pain relief and quality of life (QOL) improvement. This study was conducted to evaluate the effect of Shuangbai San on relieving pain and improving QOL in primary liver cancer patients with cancer pain. A total of 134 primary liver cancer patients with mild pain (numerical rating scale [NRS] ≤ 3), either locally in the liver or in the upper abdomen, were enrolled and randomly allocated to the group receiving Shuangbai San or the control group (receiving placebo). The primary outcome measures were the NRS score and QOL scales, including the QOL scale for patients with liver cancer, version 2.0 and the European Organization for Research and Treatment of Cancer QOL Questionnaire-C30. The secondary outcome measures included the Karnofsky Performance Status score, blood indicators, and liver and kidney function before and after treatment. The NRS scores decreased more significantly in the Shuangbai San group than in the placebo group (P < 0.05) at the corresponding time points. The changes in the scores for the physical function, psychological function, and symptoms/adverse effects domains of the QOL scale for patients with liver cancer, version 2.0 and the physical, emotional, and cognitive domains of the European Organization for Research and Treatment of Cancer QOL Questionnaire-C30 were significantly greater in the Shuangbai San group than in the placebo group (P < 0.05). The changes in the scores for the other domains were not significantly different (P > 0.05). The use of Shuangbai San can relieve mild pain in liver cancer patients and improve their QOL. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

San Jose, Costa Rica

NASA Technical Reports Server (NTRS)

2007-01-01

San Jose, capital city of Costa Rica, fills the valley between two steep mountain ranges. In this image made from data collected by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument on NASA's Terra satellite, visible, shortwave, and near-infrared wavelengths of light that the sensor observed have been combined to produce a false-color version of the scene in which vegetation is red, urban areas are silvery gray, water is dark blue, and clouds are white. The image was captured on February 8, 2007. San Jose is in the center of the image. The Rio Torres winds through downtown San Jose. Cartago, the much smaller colonial capital, sits in the lower right corner, while the city of Alajuela appears across the river, northwest of San Jose. The cities' manmade surfaces contrast sharply with the lushly vegetated landscape surrounding the city. Greenhouses are common in the region, and their glass roofs may be the brilliant white spots around the outer edges the cities. The long, straight runway of the Tobias Bolanos International Airport is visible as a dark line southeast of Alajuela. The landscape around the two cities shown here is rugged. Steep mountain peaks cast dark shadows across their leeward slopes. Patches of dark red vegetation on the mountains north of San Jose may be rainforest. Coffee plantations also cover the slopes of the mountains around the city. February is the dry season in Costa Rica. During the rainy season, from about April to November, clouds usually block the satellite's view of this tropical location. NASA image created by Jesse Allen, using data provided courtesy of Asaf Ullah and Tim Gubbels, SERVIR project.

22. Post Engineer Office, Presidio of San Francisco, Building # ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Post Engineer Office, Presidio of San Francisco, Building # 1049 Letterman General Hospital. Alterations to EKG Cardiology Clinic. November 1963. BUILDING 1049. - Presidio of San Francisco, Letterman General Hospital, Building No. 12, Letterman Hospital Complex, Edie Road, San Francisco, San Francisco County, CA

Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice: possible mediation of neurosteroid synthesis.

PubMed

Mizowaki, M; Toriizuka, K; Hanawa, T

2001-09-21

We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/benzodiazepine (GABA(A)/BZP) receptor agonist diazepam (1-3 mg/kg, i.p.), dose dependently increased the SI time, respectively. The GABA(A) receptor antagonist picrotoxin blocked the effects of TJ-24 and diazepam. TJ-24-induced SI behavior was significantly blocked by the GABA(A)/BZP receptor inverse agonist Ro 15-4513 and the GABA(A)/BZP receptor antagonist flumazenil. In addition, 5alpha-reductase inhibitor finasteride potently blocked the effect of TJ-24 without attenuating the basal level by itself. These findings suggest that TJ-24 shows the anxiolytic effect through the neurosteroid synthesis followed by GABA(A)/BDZ receptor stimulations.

MAPP in action in San Antonio, Texas.

PubMed

Shields, Kathleen M; Pruski, Charles E

2005-01-01

San Antonio was selected as an official Mobilizing for Action through Planning and Partnerships (MAPP) demonstration site by National Association of County and City Officials in 2000. The San Antonio Metropolitan Health District, under the leadership of Dr Fernando A. Guerra, agreed to facilitate the process. The MAPP process provided the San Antonio Metropolitan Health District, the local public health authority, a defined process for community health improvement, as well as a mechanism to help bridge the gap between public health and the community. The San Antonio Metropolitan Health District organized a Core Planning Team to lead the MAPP process in April 2001. By October 2002, the Core Planning Team was expanded to a full community working group named the Alliance for Community Health in San Antonio and Bexar County (Alliance). The Alliance identified six strategic issues, which eventually became the basis of the San Antonio Community Health Improvement Plan. The strategic issues are Public Policy, Data Tracking, Healthy Lifestyles, Promoting a Sense of Community, Access to Care, and Safe Environment. San Antonio's MAPP experience has been successful in bringing together the public health system partners, and establishing public health priorities collectively. The MAPP process has resulted in the development of many new initiatives, and, most important, has opened the door to many partnership opportunities in the future. The work of the Alliance, through the MAPP process, has helped to leverage resources for public health improvement in San Antonio, and has the potential to effect positive change in public health in the future.

33 CFR 165.T11-568 - Safety Zone; San Diego Symphony Summer POPS Fireworks 2013 Season, San Diego, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone; San Diego Symphony Summer POPS Fireworks 2013 Season, San Diego, CA. 165.T11-568 Section 165.T11-568 Navigation and... Areas Eleventh Coast Guard District § 165.T11-568 Safety Zone; San Diego Symphony Summer POPS Fireworks...

Fine-scale delineation of the location of and relative ground shaking within the San Andreas Fault zone at San Andreas Lake, San Mateo County, California

USGS Publications Warehouse

Catchings, R.D.; Rymer, M.J.; Goldman, M.R.; Prentice, C.S.; Sickler, R.R.

2013-01-01

The San Francisco Public Utilities Commission is seismically retrofitting the water delivery system at San Andreas Lake, San Mateo County, California, where the reservoir intake system crosses the San Andreas Fault (SAF). The near-surface fault location and geometry are important considerations in the retrofit effort. Because the SAF trends through highly distorted Franciscan mélange and beneath much of the reservoir, the exact trace of the 1906 surface rupture is difficult to determine from surface mapping at San Andreas Lake. Based on surface mapping, it also is unclear if there are additional fault splays that extend northeast or southwest of the main surface rupture. To better understand the fault structure at San Andreas Lake, the U.S. Geological Survey acquired a series of seismic imaging profiles across the SAF at San Andreas Lake in 2008, 2009, and 2011, when the lake level was near historical lows and the surface traces of the SAF were exposed for the first time in decades. We used multiple seismic methods to locate the main 1906 rupture zone and fault splays within about 100 meters northeast of the main rupture zone. Our seismic observations are internally consistent, and our seismic indicators of faulting generally correlate with fault locations inferred from surface mapping. We also tested the accuracy of our seismic methods by comparing our seismically located faults with surface ruptures mapped by Schussler (1906) immediately after the April 18, 1906 San Francisco earthquake of approximate magnitude 7.9; our seismically determined fault locations were highly accurate. Near the reservoir intake facility at San Andreas Lake, our seismic data indicate the main 1906 surface rupture zone consists of at least three near-surface fault traces. Movement on multiple fault traces can have appreciable engineering significance because, unlike movement on a single strike-slip fault trace, differential movement on multiple fault traces may exert compressive and

78 FR 57482 - Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

...-AA00 Safety Zone; America's Cup Aerobatic Box, San Francisco Bay, San Francisco, CA AGENCY: Coast Guard... America's Cup air shows. These safety zones are established to provide a clear area on the water for... announced by America's Cup Race Management. ADDRESSES: Documents mentioned in this preamble are part of...

77 FR 42649 - Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket Number USCG-2012-0497] RIN 1625-AA00 Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on...

Microsatellite analyses of San Franciscuito Creek rainbow trout

USGS Publications Warehouse

Nielsen, Jennifer L.

2000-01-01

Microsatellite genetic diversity found in San Francisquito Creek rainbow trout support a close genetic relationship with rainbow trout (Oncorhynchus mykiss) from another tributary of San Francisco Bay, Alameda Creek, and coastal trout found in Lagunitas Creek, Marin County, California. Fish collected for this study from San Francisquito Creek showed a closer genetic relationship to fish from the north-central California steelhead ESU than for any other listed group of O. mykiss. No significant genotypic or allelic frequency associations could be drawn between San Francisquito Creek trout and fish collected from the four primary rainbow trout hatchery strains in use in California, i.e. Whitney, Mount Shasta, Coleman, and Hot Creek hatchery fish. Indeed, genetic distance analyses (δµ2) supported separation between San Francisquito Creek trout and all hatchery trout with 68% bootstrap values in 1000 replicate neighbor-joining trees. Not surprisingly, California hatchery rainbow trout showed their closest evolutionary relationships with contemporary stocks derived from the Sacramento River. Wild collections of rainbow trout from the Sacramento-San Joaquin basin in the Central Valley were also clearly separable from San Francisquito Creek fish supporting separate, independent ESUs for two groups of O. mykiss (one coastal and one Central Valley) with potentially overlapping life histories in San Francisco Bay. These data support the implementation of management and conservation programs for rainbow trout in the San Francisquito Creek drainage as part of the central California coastal steelhead ESU.

75 FR 51098 - Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, Island, San Juan...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

..., Washington Maritime National Wildlife Refuge Complex, 715 Holgerson Drive, Sequim, WA 98382. FOR FURTHER...] Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, Island, San Juan, Skagit, and Whatcom Counties, WA AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability: draft...

UCSD's Institute of Engineering in Medicine: fostering collaboration through research and education.

PubMed

Chien, Shu

2012-07-01

The University of California, San Diego (UCSD) was established in 1961 as a new research university that emphasizes innovation, excellence, and interdisciplinary research and education. It has a School of Medicine (SOM) and the Jacobs School of Engineering (JSOE) in close proximity, and both schools have national rankings among the top 15. In 1991, with the support of the Whitaker Foundation, the Whitaker Institute of Biomedical Engineering was formed to foster collaborations in research and education. In 2008, the university extended the collaboration further by establishing the Institute of Engineering in Medicine (IEM), with the mission of accelerating the discoveries of novel science and technology to enhance health care through teamwork between engineering and medicine, and facilitating the translation of innovative technologies for delivery to the public through clinical application and commercialization.

Forecasting Selenium Discharges to the San Francisco Bay-Delta Estuary: Ecological Effects of A Proposed San Luis Drain Extension

USGS Publications Warehouse

Presser, Theresa S.; Luoma, Samuel N.

2006-01-01

Selenium discharges to the San Francisco Bay-Delta Estuary (Bay-Delta) could change significantly if federal and state agencies (1) approve an extension of the San Luis Drain to convey agricultural drainage from the western San Joaquin Valley to the North Bay (Suisun Bay, Carquinez Strait, and San Pablo Bay); (2) allow changes in flow patterns of the lower San Joaquin River and Bay-Delta while using an existing portion of the San Luis Drain to convey agricultural drainage to a tributary of the San Joaquin River; or (3) revise selenium criteria for the protection of aquatic life or issue criteria for the protection of wildlife. Understanding the biotransfer of selenium is essential to evaluating effects of selenium on Bay-Delta ecosystems. Confusion about selenium threats to fish and wildlife stem from (1) monitoring programs that do not address specific protocols necessary for an element that bioaccumulates; and (2) failure to consider the full complexity of the processes that result in selenium toxicity. Past studies show that predators are more at risk from selenium contamination than their prey, making it difficult to use traditional methods to predict risk from environmental concentrations alone. This report presents an approach to conceptualize and model the fate and effects of selenium under various load scenarios from the San Joaquin Valley. For each potential load, progressive forecasts show resulting (1) water-column concentration; (2) speciation; (3) transformation to particulate form; (4) particulate concentration; (5) bioaccumulation by invertebrates; (6) trophic transfer to predators; and (7) effects on those predators. Enough is known to establish a first-order understanding of relevant conditions, biological response, and ecological risks should selenium be discharged directly into the North Bay through a conveyance such as a proposed extension of the San Luis Drain. The approach presented here, the Bay-Delta selenium model, determines the mass, fate

San Diego's Capital Planning Process

ERIC Educational Resources Information Center

Lytton, Michael

2009-01-01

This article describes San Diego's capital planning process. As part of its capital planning process, the San Diego Unified School District has developed a systematic analysis of functional quality at each of its school sites. The advantage of this approach is that it seeks to develop and apply quantifiable metrics and standards for the more…

Section AA through main entrance gates & west stairs. San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Section AA through main entrance gates & west stairs. San Bernardino Valley Union Junior College, Science Building. Also includes plans and sections of boys' and girls' toilets. Howard E. Jones, Architect, San Bernardino, California. Sheet 5, job no. 311. Scales 1/4 inch to the foot (section AA) and 1/2 inch to the foot (toilet rooms). February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

San Marco C-2 Explorer

NASA Technical Reports Server (NTRS)

1974-01-01

The San Marco C-2 spacecraft will be launched no earlier than 18 February 1974 from the San Marco Range located off the coast of Kenya, Africa, by a Scout launch vehicle. The launch will be conducted by an Italian crew. The San Marco C-2 is the fourth cooperative satellite project between Italy and the United States. The purpose of the mission is to obtain measurements of the diurnal variations of the equatorial neutral atmosphere density, composition, and temperature and to use these data for correlation with AE-C (Explorer 51) data for studies of the physics and dynamics of the thermosphere. The San Marco C-2 project is a joint undertaking of the National Aeronautics and Space Administration (NASA) and the Italian Space Commission officially initiated with a Memorandum of Understanding in August of 1973. Project management responsibility for the Italian portion of the project has been assigned to the Centro Ricerche Aerospaziali (CRA) while the Goddard Space Flight Center (GSFC) has responsibility for the United States portion.

San Andreas drilling sites selected

NASA Astrophysics Data System (ADS)

Ellsworth, Bill; Zoback, Mark

A new initiative for drilling and coring directly into the San Andreas fault at depths up to 10 km is being proposed by an international team of scientists led by Mark Zoback, Stanford University; Steve Hickman and Bill Ellsworth, U.S. Geological Survey; and Lee Younker, Lawrence Livermore Laboratory. In addition to exhuming samples of fault rock and fluids from seismogenic depths, the hole will be used to make a wide range of geophysical measurements within the fault zone and to monitor the fault zone over time. Four areas along the San Andreas have been selected as candidates for deep drilling: the Mojave segment of the San Andreas between Leona Valley and Big Pine, the Carrizo Plain, the San Francisco Peninsula between Los Altos and Daly City, and the Northern Gabilan Range between the Cienga winery and Melendy Ranch. These sites were chosen from an initial list compiled at the International Fault Zone Drilling Workshop held in Asilomar, Calif., in December 1992 and at meetings held this winter and spring in Menlo Park, Calif.

Program Updates - San Antonio River Basin

EPA Pesticide Factsheets

This page will house updates for this urban waters partnership location. As projects progress, status updates can be posted here to reflect the ongoing work by partners in San Antonio working on the San Antonio River Basin.

Shelving plans, elevations, and sections. San Bernardino Valley Union Junior ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Shelving plans, elevations, and sections. San Bernardino Valley Union Junior College, Science Building. Howard E. Jones, Architect, San Bernardino, California. Sheet 9, job no. 311. Scale 1.2 inch to the foot. February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

76 FR 19781 - Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, San Juan, Skagit...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

...., Lopez Island, WA 98261. North Olympic Public Library..... 630 N. Sequim Ave., 360-683-1161 Sequim, WA...] Protection Island and San Juan Islands National Wildlife Refuges, Jefferson, San Juan, Skagit, Island, and Whatcom Counties, WA; Final Comprehensive Conservation Plan, Wilderness Stewardship Plan, and Finding of...

22. Photocopy of photograph (from San Francisco Chronicle Collection) Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of photograph (from San Francisco Chronicle Collection) Photographer unknown, Date unknown SIDE VIEW OF CHURCH - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

Cataclastic rocks of the San Gabriel fault—an expression of deformation at deeper crustal levels in the San Andreas fault zone

NASA Astrophysics Data System (ADS)

Anderson, J. Lawford; Osborne, Robert H.; Palmer, Donald F.

1983-10-01

The San Gabriel fault, a deeply eroded late Oligocene to middle Pliocene precursor to the San Andreas, was chosen for petrologic study to provide information regarding intrafault material representative of deeper crustal levels. Cataclastic rocks exposed along the present trace of the San Andreas in this area are exclusively a variety of fault gouge that is essentially a rock flour with a quartz, feldspar, biotite, chlorite, amphibole, epidote, and Fe-Ti oxide mineralogy representing the milled-down equivalent of the original rock (Anderson and Osborne, 1979; Anderson et al., 1980). Likewise, fault gouge and associated breccia are common along the San Gabriel fault, but only where the zone of cataclasis is several tens of meters wide. At several localities, the zone is extremely narrow (several centimeters), and the cataclastic rock type is cataclasite, a dark, aphanitic, and highly comminuted and indurated rock. The cataclastic rocks along the San Gabriel fault exhibit more comminution than that observed for gouge along the San Andreas. The average grain diameter for the San Andreas gouge ranges from 0.01 to 0.06 mm. For the San Gabriel cataclastic rocks, it ranges from 0.0001 to 0.007 mm. Whereas the San Andreas gouge remains particulate to the smallest grain-size, the ultra-fine grain matrix of the San Gabriel cataclasite is composed of a mosaic of equidimensional, interlocking grains. The cataclastic rocks along the San Gabriel fault also show more mineralogiec changes compared to gouge from the San Andreas fault. At the expense of biotite, amphibole, and feldspar, there is some growth of new albite, chlorite, sericite, laumontite, analcime, mordenite (?), and calcite. The highest grade of metamorphism is laumontite-chlorite zone (zeolite facies). Mineral assemblages and constrained uplift rates allow temperature and depth estimates of 200 ± 30° C and 2-5 km, thus suggesting an approximate geothermal gradient of ~50°C/km. Such elevated temperatures imply a

76 FR 9709 - Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... Bay Delta Estuary is the hub of California's water distribution system, supplying some or all of the... Water Quality Challenges in the San Francisco Bay/Sacramento-San Joaquin Delta Estuary AGENCY... interested parties on possible EPA actions to address water quality conditions affecting aquatic resources in...

South elevation and main floor plan. San Bernardino Valley Union ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

South elevation and main floor plan. San Bernardino Valley Union Junior College, Science Building. Includes chemistry and botany departments. Howard E. Jones, Architect, San Bernardino, California. Sheet 2, job no. 311. Scale 1/8 inch to the foot. February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

Nursing students' opinions about acupuncture and Chinese medicine.

PubMed

Weber, J P

1975-01-01

Eighty senior nursing students at the University of San Francisco (USF) were divided at random into four groups of 20. Two groups were pretested on their knowledge of acupuncture and Chinese medicine. One week later a 50-minute class in acupuncture and Chinese medicine was given in a community health class to one of the two pretexted groups and one of the two untested groups. Following the class, the test was given to all four groups. Using the Solomon Four-Group design to measure effects of pretesting and the class content, significant differences were found between the groups on questions seeking differences, to confirm the first hypothesis that an increase in knowledge about acupuncture and Chinese medicine will accompany an increase in its acceptance as a healing tool and the desire to learn more about it. A t-test on the results of pre- and post- tests confirmed the second hypothesis that there will be no difference between groups in history or maturation from one week to the next.

1. VIEW LOOKING SOUTHWEST AT TURNOUT ON SAN TAN FLOODWATER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW LOOKING SOUTHWEST AT TURNOUT ON SAN TAN FLOOD-WATER CANAL TO SAN TAN INDIAN CANAL - San Carlos Irrigation Project, San Tan Flood Water Canal, North Side of Gila River, Coolidge, Pinal County, AZ

77 FR 37604 - Safety Zone; Fourth of July Fireworks, City of San Francisco, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... Zone; Fourth of July Fireworks, City of San Francisco, San Francisco, CA AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the safety zone for... anchoring in the safety zone, unless authorized by the Patrol Commander (PATCOM). DATES: The regulations in...

Sam Ho on health system quality and population medicine. Interview by Nancy Houyoux.

PubMed

Ho, Sam

2003-01-01

As PacifiCare Health Systems' senior vice president and chief medical officer, Dr. Sam Ho is responsible for developing and implementing strategies and programs to improve the quality and cost-effectiveness of healthcare services throughout the company. Dr. Ho is responsible for all initiatives related to quality assessment and improvement, medical management, disease management, informatics, report cards, clinical product development, e-health, and healthcare liaison with public policy, government affairs, industry relations, media relations, provider network management, and sales and marketing. Since joining PacifiCare in its California MCO in October 1994, he has spearheaded companywide quality initiatives and improvement in population health outcomes, and developed the QUALITY INDEX profile of medical groups, a consumer-focused report card of provider performance. He also led efforts to achieve systemwide accreditation by the National Committee for Quality Assurance in all markets and Health Plan Employer Data and Information Set (HEDIS) score improvements. Previously he served as deputy director of health, medical director, and county health officer for the San Francisco Department of Public Health. He has held faculty appointments at the Schools of both Medicine and Nursing at the University of California, San Francisco. The Honolulu native received his BA in sociology from Northwestern University in 1972 with Phi Beta Kappa honors and his MD from Tufts University School of Medicine in 1976. Dr. Ho completed his residency in family practice at the University of California, San Francisco, and has since maintained board certification with the American Board of Family Practice.

San Francisco and Bay Area, CA, USA

NASA Image and Video Library

1991-06-14

STS040-152-100 (5-14 June 1991) --- Although clouds obscure part of the city of San Francisco and the mouth of San Francisco Bay, development and physiographic features in the immediate vicinity of the bay are well displayed. The photograph clearly shows the eastern part of the city, including the Embarcadero, the Bay Bridge, which was damaged in the 1989 earthquake, and Candlestick Park, San Mateo, and Dumbarton Bridges, cross the southern portion of the bay. Vari-colored salt ponds also rim the southern Bay near Moffett Field. Highway 280 runs along the San Andreas fault south of the city. On the eastern margin of the bay are Berkeley the Sacramento River and the Haywood and Calaveras faults.

33 CFR 165.T11-560 - Safety Zone; Sea World San Diego Fireworks 2013 Season, Mission Bay; San Diego, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone; Sea World San Diego Fireworks 2013 Season, Mission Bay; San Diego, CA. 165.T11-560 Section 165.T11-560 Navigation and Navigable... Eleventh Coast Guard District § 165.T11-560 Safety Zone; Sea World San Diego Fireworks 2013 Season, Mission...

Toxic phytoplankton in San Francisco Bay

USGS Publications Warehouse

Rodgers, Kristine M.; Garrison, David L.; Cloern, James E.

1996-01-01

The Regional Monitoring Program (RMP) was conceived and designed to document the changing distribution and effects of trace substances in San Francisco Bay, with focus on toxic contaminants that have become enriched by human inputs. However, coastal ecosystems like San Francisco Bay also have potential sources of naturally-produced toxic substances that can disrupt food webs and, under extreme circumstances, become threats to public health. The most prevalent source of natural toxins is from blooms of algal species that can synthesize metabolites that are toxic to invertebrates or vertebrates. Although San Francisco Bay is nutrient-rich, it has so far apparently been immune from the epidemic of harmful algal blooms in the world’s nutrient-enriched coastal waters. This absence of acute harmful blooms does not imply that San Francisco Bay has unique features that preclude toxic blooms. No sampling program has been implemented to document the occurrence of toxin-producing algae in San Francisco Bay, so it is difficult to judge the likelihood of such events in the future. This issue is directly relevant to the goals of RMP because harmful species of phytoplankton have the potential to disrupt ecosystem processes that support animal populations, cause severe illness or death in humans, and confound the outcomes of toxicity bioassays such as those included in the RMP. Our purpose here is to utilize existing data on the phytoplankton community of San Francisco Bay to provide a provisional statement about the occurrence, distribution, and potential threats of harmful algae in this Estuary.

Foundation plan. San Bernardino Valley Union Junior College, Classics Building. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Foundation plan. San Bernardino Valley Union Junior College, Classics Building. Also includes sections AA-KK (except DD). Howard E. Jones, Architect, San Bernardino, California. Sheet 1, job no. 312. Scales 1/8 inch to the foot (plan) and 1/2 inch to the foot (sections). February 15, 1927. - San Bernardino Valley College, Classics Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

Details of main entrance. San Bernardino Valley Union Junior College, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Details of main entrance. San Bernardino Valley Union Junior College, Classics Building. Half elevation of exterior iron gates, half plan of interior with tiling, and section AA. Howard E. Jones, Architect, San Bernardino, California. Sheet 5, job no. 312. Scale 1/2 inch to the foot. February 15, 1927. - San Bernardino Valley College, Classics Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

33 CFR 110.210 - San Diego Harbor, CA.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false San Diego Harbor, CA. 110.210... ANCHORAGE REGULATIONS Anchorage Grounds § 110.210 San Diego Harbor, CA. (a) The anchorage grounds. (1... Commander, Naval Base, San Diego, CA. The administration of these anchorages is exercised by the Commander...

33 CFR 110.210 - San Diego Harbor, CA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false San Diego Harbor, CA. 110.210... ANCHORAGE REGULATIONS Anchorage Grounds § 110.210 San Diego Harbor, CA. (a) The anchorage grounds. (1... Commander, Naval Base, San Diego, CA. The administration of these anchorages is exercised by the Commander...

33 CFR 110.210 - San Diego Harbor, CA.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false San Diego Harbor, CA. 110.210... ANCHORAGE REGULATIONS Anchorage Grounds § 110.210 San Diego Harbor, CA. (a) The anchorage grounds. (1... Commander, Naval Base, San Diego, CA. The administration of these anchorages is exercised by the Commander...

33 CFR 110.210 - San Diego Harbor, CA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false San Diego Harbor, CA. 110.210... ANCHORAGE REGULATIONS Anchorage Grounds § 110.210 San Diego Harbor, CA. (a) The anchorage grounds. (1... Commander, Naval Base, San Diego, CA. The administration of these anchorages is exercised by the Commander...

21. Post Engineer Office, Presidio of San Francisco, Letterman Army ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Post Engineer Office, Presidio of San Francisco, Letterman Army Hospital. EKG Cardiology Clinic, Building 1049. December 1955. BUILDING 1049. - Presidio of San Francisco, Letterman General Hospital, Building No. 12, Letterman Hospital Complex, Edie Road, San Francisco, San Francisco County, CA

Modeling pesticide diuron loading from the San Joaquin watershed into the Sacramento-San Joaquin Delta using SWAT

USDA-ARS?s Scientific Manuscript database

Quantitative information on pesticide loading into the Sacramento-San Joaquin Delta waterways of northern California is critical for water resource management in the region, and potentially useful for biological weed control planning. The San Joaquin watershed, an agriculturally intensive area, is a...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false San Diego Bay, California. 165... Navigation Areas and Limited Access Areas Eleventh Coast Guard District § 165.1107 San Diego Bay, California... docking/undocking operations at the U.S. Naval Submarine Base on Ballast Point, San Diego Bay, California...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false San Diego Bay, California. 165... Navigation Areas and Limited Access Areas Eleventh Coast Guard District § 165.1107 San Diego Bay, California... docking/undocking operations at the U.S. Naval Submarine Base on Ballast Point, San Diego Bay, California...

33 CFR 165.1107 - San Diego Bay, California.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false San Diego Bay, California. 165... Navigation Areas and Limited Access Areas Eleventh Coast Guard District § 165.1107 San Diego Bay, California... docking/undocking operations at the U.S. Naval Submarine Base on Ballast Point, San Diego Bay, California...

North elevation and second floor plan. San Bernardino Valley Union ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

North elevation and second floor plan. San Bernardino Valley Union Junior College, Science Building. Includes physics, geology, and zoology departments shelving. Howard E. Jones, Architect, San Bernardino, California. Sheet 4, job no. 311. Scales 1/8 inch to the foot (elevations) and 1/2 inch to the foot (shelving). February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

East and west elevations. San Berardino Valley Union Junior College, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

East and west elevations. San Berardino Valley Union Junior College, Science Building. Also includes elevations and sections of chemistry department shelving. Howard E. Jones, Architect, San Bernardino, California. Sheet 4, Job no. 311. Scales 1/8 inch to the foot (elevations) and 1/2 inch t other foot (shelving). February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

Performance of San Fernando dams during 1994 Northridge earthquake

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bardet, J.P.; Davis, C.A.

1996-07-01

The 1994 Northridge and 1971 San Fernando Earthquakes subjected the Lower and Upper San Fernando Dams of the Van Norman Complex in the San Fernando Valley, Calif., to strong near-source ground motions. In 1994, these earth dams, which were out of service and retained only a few meters of water, extensively cracked and settled due to the liquefaction of their hydraulic fill. The Lower San Fernando Dam moved over 15 cm upstream as the hydraulic fill liquefied beneath its upstream slope. The Upper San Fernando Dam moved even more and deformed in a complicated three-dimensional pattern. The responses of themore » Lower and Upper San Fernando Dams during the 1994 Northridge Earthquake, although less significant than in 1971, provide the geotechnical engineering community with two useful case histories.« less

19. REGIONAL MAP, SALINAS RIVER PROJECT, CAMP SAN LUIS OBISPO, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. REGIONAL MAP, SALINAS RIVER PROJECT, CAMP SAN LUIS OBISPO, IN CENTRAL PORTION OF SAN LUIS OBISPO, CALIFORNIA. Leeds Hill Barnard & Jewett - Consulting Engineers, February 1942. - Salinas River Project, Cuesta Tunnel, Southeast of U.S. 101, San Luis Obispo, San Luis Obispo County, CA

Modeling pesticide loadings from the San Joaquin watershed into the Sacramento-San Joaquin Delta using SWAT

NASA Astrophysics Data System (ADS)

Chen, H.; Zhang, M.

2016-12-01

The Sacramento-San Joaquin Delta is an ecologically rich, hydrologically complex area that serves as the hub of California's water supply. However, pesticides have been routinely detected in the Delta waterways, with concentrations exceeding the benchmark for the protection of aquatic life. Pesticide loadings into the Delta are partially attributed to the San Joaquin watershed, a highly productive agricultural watershed located upstream. Therefore, this study aims to simulate pesticide loadings to the Delta by applying the Soil and Water Assessment Tool (SWAT) model to the San Joaquin watershed, under the support of the USDA-ARS Delta Area-Wide Pest Management Program. Pesticide use patterns in the San Joaquin watershed were characterized by combining the California Pesticide Use Reporting (PUR) database and GIS analysis. Sensitivity/uncertainty analyses and multi-site calibration were performed in the simulation of stream flow, sediment, and pesticide loads along the San Joaquin River. Model performance was evaluated using a combination of graphic and quantitative measures. Preliminary results indicated that stream flow was satisfactorily simulated along the San Joaquin River and the major eastern tributaries, whereas stream flow was less accurately simulated in the western tributaries, which are ephemeral small streams that peak during winter storm events and are mainly fed by irrigation return flow during the growing season. The most sensitive parameters to stream flow were CN2, SOL_AWC, HRU_SLP, SLSUBBSN, SLSOIL, GWQMN and GW_REVAP. Regionalization of parameters is important as the sensitivity of parameters vary significantly spatially. In terms of evaluation metric, NSE tended to overrate model performance when compared to PBIAS. Anticipated results will include (1) pesticide use pattern analysis, (2) calibration and validation of stream flow, sediment, and pesticide loads, and (3) characterization of spatial patterns and temporal trends of pesticide yield.

Sediment characteristics in the San Antonio River Basin downstream from San Antonio, Texas, and at a site on the Guadalupe River downstream from the San Antonio River Basin, 1966-2013

USGS Publications Warehouse

Crow, Cassi L.; Banta, J. Ryan; Opsahl, Stephen P.

2014-01-01

San Antonio and surrounding municipalities in Bexar County, Texas, are in a rapidly urbanizing region in the San Antonio River Basin. The U.S. Geological Survey, in cooperation with the San Antonio River Authority and the Texas Water Development Board, compiled historical sediment data collected between 1996 and 2004 and collected suspended-sediment and bedload samples over a range of hydrologic conditions in the San Antonio River Basin downstream from San Antonio, Tex., and at a site on the Guadalupe River downstream from the San Antonio River Basin during 2011–13. In the suspended-sediment samples collected during 2011–13, an average of about 94 percent of the particles was less than 0.0625 millimeter (silt and clay sized particles); the 50 samples for which a complete sediment-size analysis was performed indicated that an average of about 69 percent of the particles was less than 0.002 millimeter. In the bedload samples collected during 2011–13, an average of 51 percent of sediment particles was sand-sized particles in the 0.25–0.5 millimeter-size range. In general, the loads calculated from the samples indicated that bedload typically composed less than 1 percent of the total sediment load. A least-squares log-linear regression was developed between suspended-sediment concentration and instantaneous streamflow and was used to estimate daily mean suspended-sediment loads based on daily mean streamflow. The daily mean suspended-sediment loads computed for each of the sites indicated that during 2011–12, the majority of the suspended-sediment loads originated upstream from the streamflow-gaging station on the San Antonio River near Elmendorf, Tex. A linear regression relation was developed between turbidity and suspended-sediment concentration data collected at the San Antonio River near Elmendorf site because the high-resolution data can facilitate understanding of the complex suspended-sediment dynamics over time and throughout the river basin.

78 FR 39588 - Special Local Regulations; Revision of 2013 America's Cup Regulated Area, San Francisco Bay; San...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

...-AA08 Special Local Regulations; Revision of 2013 America's Cup Regulated Area, San Francisco Bay; San...: The Coast Guard is revising the regulated area for the 2013 America's Cup sailing events. Previously... final rule regulating the on-water activities associated with the ``Louis Vuitton Cup,'' ``Red Bull...

77 FR 50921 - Safety Zone: Bay Bridge Load Transfer Safety Zone, San Francisco Bay, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

...-AA00 Safety Zone: Bay Bridge Load Transfer Safety Zone, San Francisco Bay, San Francisco, CA AGENCY... the Bay Bridge Load Transfer Safety Zone from August 1, 2012 through October 31, 2012. This safety... Bay Bridge from the temporary suspension arrangement to the permanent suspension arrangement, the...

Distribution and demography of San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) at Mindego Ranch, Russian Ridge Open Space Preserve, San Mateo County, California

USGS Publications Warehouse

Kim, Richard; Halstead, Brian J.; Wylie, Glenn D.; Casazza, Michael L.

2018-04-26

San Francisco gartersnakes (Thamnophis sirtalis tetrataenia) are a subspecies of common gartersnakes endemic to the San Francisco Peninsula of northern California. Because of habitat loss and collection for the pet trade, San Francisco gartersnakes were listed as endangered under the precursor to the Federal Endangered Species Act. A population of San Francisco gartersnakes resides at Mindego Ranch, San Mateo County, which is part of the Russian Ridge Open Space Preserve owned and managed by the Midpeninsula Regional Open Space District (MROSD). Because the site contained non-native fishes and American bullfrogs (Lithobates catesbeianus), MROSD implemented management to eliminate or reduce the abundance of these non-native species in 2014. We monitored the population using capture-mark-recapture techniques to document changes in the population during and following management actions. Although drought confounded some aspects of inference about the effects of management, prey and San Francisco gartersnake populations generally increased following draining of Aquatic Feature 3. Continued management of the site to keep invasive aquatic predators from recolonizing or increasing in abundance, as well as vegetation management that promotes heterogeneous grassland/shrubland near wetlands, likely would benefit this population of San Francisco gartersnakes.

1. SAN FRANCISCO STREET PROFILES: Photocopy of engraving, c. 1880, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. SAN FRANCISCO STREET PROFILES: Photocopy of engraving, c. 1880, showing street profiles of three San Francisco cable lines. Figure 7, at bottom of engraving, is the profile of Hallidie's Clay Street Hill Railroad. Figures 8 and 9 show the grades for the California Street Cable Railroad and the Geary Street Park & Ocean Railroad respectively. Note the lack of significant grades along Geary Street. - San Francisco Cable Railway, Washington & Mason Streets, San Francisco, San Francisco County, CA

Elevation and plan of east side entrance. San Bernardino Valley ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Elevation and plan of east side entrance. San Bernardino Valley Union Junior College, Library Building. Also includes sections II and SS of entrance hall; and a stress diagram of steel truss. Howard E. Jones, Architect, San Bernardino, California. Sheet 7, job no. 315. Scale 1/2 inch to the foot. No date given on sheet (probably March or April, 1927). - San Bernardino Valley College, Library, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

West elevation. San Bernardino Valley Union Junior College, Science Building. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West elevation. San Bernardino Valley Union Junior College, Science Building. Also includes plan of entrance, section EE showing tiling and typical transom design, and a full size detail of a door jamb for inside concrete walls. Howard E. Jones, Architect, San Bernardino, California. Sheet 7, job no. 311. Scale 1.2 inch to the foot. February 15, 1927. - San Bernardino Valley College, Life Science Building, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

78 FR 48044 - Safety Zone; San Diego International Airport Terminal Two West Grand Opening Fireworks; San Diego...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-07

...-AA00 Safety Zone; San Diego International Airport Terminal Two West Grand Opening Fireworks; San Diego... Opening of Lindbergh Airport Terminal Two West on August 8, 2013. This temporary safety zone is necessary... Diego International Airport Terminal Two grand opening. This safety zone is necessary to provide for the...

78 FR 28800 - Foreign-Trade Zone 61-San Juan, Puerto Rico; Application for Subzone; Parapiezas Corporation; San...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

..., Puerto Rico; Application for Subzone; Parapiezas Corporation; San Juan, Puerto Rico An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Puerto Rico Trade & Export Company... located in San Juan, Puerto Rico. The application was submitted pursuant to the provisions of the Foreign...

78 FR 21397 - Don Edwards San Francisco Bay National Wildlife Refuge, Alameda, Santa Clara, and San Mateo...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

...) 792-5828. Mail: U.S. Fish and Wildlife Service, San Francisco Bay NWR Complex, 1 Marshlands Road... the San Francisco Bay National Wildlife Refuge Complex, 1 Marshlands Road, Fremont, CA 94555 (510) 792... and environmental education. We announce our decision and the availability of the FONSI for the final...

Geophysical Surveys of the San Andreas and Crystal Springs Reservoir System Including Seismic-Reflection Profiles and Swath Bathymetry, San Mateo County, California

USGS Publications Warehouse

Finlayson, David P.; Triezenberg, Peter J.; Hart, Patrick E.

2010-01-01

This report describes geophysical data acquired by the U.S. Geological Survey (USGS) in San Andreas Reservoir and Upper and Lower Crystal Springs Reservoirs, San Mateo County, California, as part of an effort to refine knowledge of the location of traces of the San Andreas Fault within the reservoir system and to provide improved reservoir bathymetry for estimates of reservoir water volume. The surveys were conducted by the Western Coastal and Marine Geology (WCMG) Team of the USGS for the San Francisco Public Utilities Commission (SFPUC). The data were acquired in three separate surveys: (1) in June 2007, personnel from WCMG completed a three-day survey of San Andreas Reservoir, collecting approximately 50 km of high-resolution Chirp subbottom seismic-reflection data; (2) in November 2007, WCMG conducted a swath-bathymetry survey of San Andreas reservoir; and finally (3) in April 2008, WCMG conducted a swath-bathymetry survey of both the upper and lower Crystal Springs Reservoir system. Top of PageFor more information, contact David Finlayson.

Examination of spotted sand bass (Paralabrax maculatofasciatus) pollutant bioaccumulation in San Diego Bay, San Diego, California

PubMed Central

2013-01-01

The spotted sand bass (Paralabrax maculatofasciatus) is an important recreational sport and subsistence food fish within San Diego Bay, a large industrialized harbor in San Diego, California. Despite this importance, few studies examining the species life history relative to pollutant tissue concentrations and the consumptive fishery exist. This study utilized data from three independent spotted sand bass studies from 1989 to 2002 to investigate PCB, DDT, and mercury tissue concentrations relative to spotted sand bass age and growth in San Diego Bay, with subsequent comparisons to published pollutant advisory levels and fishery regulations for recreational and subsistence consumption of the species. Subsequent analysis focused on examining temporal and spatial differences for different regions of San Diego Bay. Study results for growth confirmed previous work, finding the species to exhibit highly asymptotic growth, making tissue pollutant concentrations at initial take size difficult if not impossible to predict. This was corroborated by independent tissue concentration results for mercury, which found no relationship between fish size and pollutant bioaccumulation observed. However, a positive though highly variable relationship was observed between fish size and PCB tissue concentration. Despite these findings, a significant proportion of fish exhibited pollutant levels above recommended state recreational angler consumption advisory levels for PCBs and mercury, especially for fish above the minimum take size, making the necessity of at-size predictions less critical. Lastly, no difference in tissue concentration was found temporally or spatially within San Diego Bay. PMID:24282672

Examination of spotted sand bass (Paralabrax maculatofasciatus) pollutant bioaccumulation in San Diego Bay, San Diego, California.

PubMed

Loflen, Chad L

2013-01-01

The spotted sand bass (Paralabrax maculatofasciatus) is an important recreational sport and subsistence food fish within San Diego Bay, a large industrialized harbor in San Diego, California. Despite this importance, few studies examining the species life history relative to pollutant tissue concentrations and the consumptive fishery exist. This study utilized data from three independent spotted sand bass studies from 1989 to 2002 to investigate PCB, DDT, and mercury tissue concentrations relative to spotted sand bass age and growth in San Diego Bay, with subsequent comparisons to published pollutant advisory levels and fishery regulations for recreational and subsistence consumption of the species. Subsequent analysis focused on examining temporal and spatial differences for different regions of San Diego Bay. Study results for growth confirmed previous work, finding the species to exhibit highly asymptotic growth, making tissue pollutant concentrations at initial take size difficult if not impossible to predict. This was corroborated by independent tissue concentration results for mercury, which found no relationship between fish size and pollutant bioaccumulation observed. However, a positive though highly variable relationship was observed between fish size and PCB tissue concentration. Despite these findings, a significant proportion of fish exhibited pollutant levels above recommended state recreational angler consumption advisory levels for PCBs and mercury, especially for fish above the minimum take size, making the necessity of at-size predictions less critical. Lastly, no difference in tissue concentration was found temporally or spatially within San Diego Bay.

San Francisco and Bay Area, CA, USA

NASA Image and Video Library

1973-06-22

SL2-03-118 (June 1973) --- An infrared photograph of the San Francisco Bay, California area, taken from the Skylab 1/2 space station in Earth orbit. THE PICTURE SHOULD BE HELD WITH THE CLOUDS AND PACIFIC OCEAN ON THE LEFT. This photograph was taken by one of the six lenses of the Itek-furnished S190-A Multispectral Photographic Facility Experiment in the Multiple Docking Adapter of the space station. Type 2443 film was used. Note the thickly populated and highly developed area around the bay. Among the cities visible in this photograph are San Francisco, Oakland, Berkeley and San Jose. This view extends eastward to show a portion of the San Joaquin Valley. The S190-A experiment is part of the Skylab Earth Resources Experiment Package (EREP). Photo credit: NASA

75 FR 61611 - Modification of Class E Airspace; San Clemente, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... [Modified] San Clemente Island NALF (Fredrick Sherman Field), CA (Lat. 33[deg]01'22'' N., long. 118[deg]35'19'' W.) San Clemente Island TACAN (Lat. 33[deg]01'37'' N., long. 118[deg]34'46'' W.) That airspace... San Clemente, CA. Decommissioning of the San Clemente Island Non-Directional Radio Beacon (NDB) at San...

San Francisco Bay Long Term Management Strategy for Dredging

EPA Pesticide Factsheets

The San Francisco Bay Long Term Management Strategy (LTMS) is a cooperative effort to develop a new approach to dredging and dredged material disposal in the San Francisco Bay area. The LTMS serves as the Regional Dredging Team for the San Francisco area.

76 FR 22809 - Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

...-AA00 Safety Zone; Bay Ferry II Maritime Security Exercise; San Francisco Bay, San Francisco, CA AGENCY... Security Exercise, a multi-agency exercise that tests the proficiency of teams called upon in real [[Page... exercise, many of whom will be traveling at high speeds while interfacing with law enforcement responders...

Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials.

PubMed

Luo, Qiulan; Zhang, Claire Shuiqing; Yang, Lihong; Zhang, Anthony Lin; Guo, Xinfeng; Xue, Charlie Changli; Lu, Chuanjian

2017-11-06

Chinese herbal medicine formula Yu ping feng san (YPFS) is commonly used for allergic rhinitis (AR). Previous review had summarized the effectiveness and safety of YPFS, however without any subgroup analysis performed to provide detailed evidence for guiding clinical practice. YPFS was recommended for the management of AR by Chinese medicine clinical practice guideline, but the treatment duration of YPFS was also not specified. The aim of this study is to evaluate the effectiveness and safety of YPFS in treating adult AR with the most recent evidence, and attempt to specify the duration of utilisation through subgroup meta-analyses. Seven databases were searched from their inceptions to September 2017. Randomized controlled trials (RCTs) evaluating YPFS for adult AR were included. Methodological quality of studies was assessed using the Cochrane risk of bias tool. Meta-analysis and subgroup meta-analyses were conducted for evaluating the effectiveness of YPFS. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used for rating the quality of evidence. Twenty-two RCTs involving 23 comparisons were included in this review. YPFS was compared to placebo, pharmacotherapy, and used as an add-on treatment compared to pharmacotherapy. Meta-analyses were feasible for the outcomes of four individual nasal symptom scores and "effective rate". Four individual nasal symptom scores decreased after YPFS' combination treatment: itchy nose (MD-0.46, 95% CI[-0.50, -0.42]), sneezing (MD-0.41, 95% CI[-0.47, -0.35]), blocked nose (MD-0.46, 95% CI[-0.54, -0.39]) and runny nose (MD-0.42, 95% CI[-0.58, -0.26]). Based on "effective rate", meta-analysis showed that YPFS did not achieve better effect than pharmacotherapy (RR1.07, 95%CI [0.94, 1.22), but its combination with pharmacotherapy seemed more effective than pharmacotherapy alone (RR1.27, 95%CI [1.19, 1.34]) (low quality). Subgroup analysis suggested that YPFS was not superior to the second

ASTER Images San Francisco Bay Area

NASA Technical Reports Server (NTRS)

2000-01-01

This image of the San Francisco Bay region was acquired on March 3, 2000 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters about 50 to 300 feet ), ASTER will image Earth for the next 6 years to map and monitor the changing surface of our planet.

Image: This image covers an area 60 kilometers (37 miles) wide and 75 kilometers (47 miles) long in three bands of the reflected visible and infrared wavelength region. The combination of bands portrays vegetation in red, and urban areas in gray. Sediment in the Suisun Bay, San Pablo Bay, San Francisco Bay, and the Pacific Ocean shows up as lighter shades of blue. Along the west coast of the San Francisco Peninsula, strong surf can be seen as a white fringe along the shoreline. A powerful rip tide is visible extending westward from Daly City into the Pacific Ocean. In the lower right corner, the wetlands of the South San Francisco Bay National Wildlife Refuge appear as large dark blue and brown polygons. The high spatial resolution of ASTER allows fine detail to be observed in the scene. The main bridges of the area (San Mateo, San Francisco-Oakland Bay, Golden Gate, Richmond-San Rafael, Benicia-Martinez, and Carquinez) are easily picked out, connecting the different communities in the Bay area. Shadows of the towers along the Bay Bridge can be seen over the adjacent bay water. With enlargement the entire road network can be easily mapped; individual buildings are visible, including the shadows of the high-rises in downtown San Francisco.

Inset: This enlargement of the San Francisco Airport highlights the high spatial resolution of ASTER. With further enlargement and careful examination, airplanes can be seen at the terminals.

Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five Earth

75 FR 8804 - Safety Zone; NASSCO Launching of USNS Charles Drew, San Diego Bay, San Diego, CA.

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

...-AA00 Safety Zone; NASSCO Launching of USNS Charles Drew, San Diego Bay, San Diego, CA. AGENCY: Coast... United States Naval Ship (USNS) Charles Drew. The safety zone is necessary to provide for the safety of... to the safety of the USNS Charles Drew and surrounding vessels as this ship launches from NASSCO...

Quaternary geology of Alameda County, and parts of Contra Costa, Santa Clara, San Mateo, San Francisco, Stanislaus, and San Joaquin counties, California: a digital database

USGS Publications Warehouse

Helley, E.J.; Graymer, R.W.

1997-01-01

Alameda County is located at the northern end of the Diablo Range of Central California. It is bounded on the north by the south flank of Mount Diablo, one of the highest peaks in the Bay Area, reaching an elevation of 1173 meters (3,849 ft). San Francisco Bay forms the western boundary, the San Joaquin Valley borders it on the east and an arbitrary line from the Bay into the Diablo Range forms the southern boundary. Alameda is one of the nine Bay Area counties tributary to San Francisco Bay. Most of the country is mountainous with steep rugged topography. Alameda County is covered by twenty-eight 7.5' topographic Quadrangles which are shown on the index map. The Quaternary deposits in Alameda County comprise three distinct depositional environments. One, forming a transgressive sequence of alluvial fan and fan-delta facies, is mapped in the western one-third of the county. The second, forming only alluvial fan facies, is mapped in the Livermore Valley and San Joaquin Valley in the eastern part of the county. The third, forming a combination of Eolian dune and estuarine facies, is restricted to the Alameda Island area in the northwestern corner of the county.

San Francisco Bay Water Quality Improvement Fund

EPA Pesticide Factsheets

EPAs grant program to protect and restore San Francisco Bay. The San Francisco Bay Water Quality Improvement Fund (SFBWQIF) has invested in 58 projects along with 70 partners contributing to restore wetlands, water quality, and reduce polluted runoff.,

San Francisco vessel traffic service watchstander analysis

DOT National Transportation Integrated Search

1979-11-01

A team of human factors specialists analyzed the performance of watchstanders in the U.S. Coast Guard's San Francisco Vessel Traffic Center at Yerba Buena Island, San Francisco, California. Data collected included copies of the center's forms and log...

San Diego's High School Dropout Crisis

ERIC Educational Resources Information Center

Wilson, James C.

2012-01-01

This article highlights San Diego's dropout problem and how much it's costing the city and the state. Most San Diegans do not realize the enormous impact high school dropouts on their city. The California Dropout Research Project, located at the University of California at Santa Barbara, has estimated the lifetime cost of one class or cohort of…

Neogene contraction between the San Andreas fault and the Santa Clara Valley, San Francisco Bay region, California

USGS Publications Warehouse

McLaughlin, R.J.; Langenheim, V.E.; Schmidt, K.M.; Jachens, R.C.; Stanley, R.G.; Jayko, A.S.; McDougall, K.A.; Tinsley, J.C.; Valin, Z.C.

1999-01-01

In the southern San Francisco Bay region of California, oblique dextral reverse faults that verge northeastward from the San Andreas fault experienced triggered slip during the 1989 M7.1 Loma Prieta earthquake. The role of these range-front thrusts in the evolution of the San Andreas fault system and the future seismic hazard that they may pose to the urban Santa Clara Valley are poorly understood. Based on recent geologic mapping and geophysical investigations, we propose that the range-front thrust system evolved in conjunction with development of the San Andreas fault system. In the early Miocene, the region was dominated by a system of northwestwardly propagating, basin-bounding, transtensional faults. Beginning as early as middle Miocene time, however, the transtensional faulting was superseded by transpressional NE-stepping thrust and reverse faults of the range-front thrust system. Age constraints on the thrust faults indicate that the locus of contraction has focused on the Monte Vista, Shannon, and Berrocal faults since about 4.8 Ma. Fault slip and fold reconstructions suggest that crustal shortening between the San Andreas fault and the Santa Clara Valley within this time frame is ~21%, amounting to as much as 3.2 km at a rate of 0.6 mm/yr. Rates probably have not remained constant; average rates appear to have been much lower in the past few 100 ka. The distribution of coseismic surface contraction during the Loma Prieta earthquake, active seismicity, late Pleistocene to Holocene fluvial terrace warping, and geodetic data further suggest that the active range-front thrust system includes blind thrusts. Critical unresolved issues include information on the near-surface locations of buried thrusts, the timing of recent thrust earthquake events, and their recurrence in relation to earthquakes on the San Andreas fault.

76 FR 10945 - San Luis Trust Bank, FSB, San Luis Obispo, CA; Notice of Appointment of Receiver

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision San Luis Trust Bank, FSB, San Luis Obispo... contained in section 5(d)(2) of the Home Owners' Loan Act, the Office of Thrift Supervision has duly... Thrift Supervision. Sandra E. Evans, Federal Register Liaison. [FR Doc. 2011-4306 Filed 2-25-11; 8:45 am...

1. Historic American Buildings Survey San Francisco Chronicle Library Rephoto ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey San Francisco Chronicle Library Re-photo May 1940 TAKEN 1849-50 - Abandoned Ships, Historic View, 1849-1850, Yerba Beuna Cove, San Francisco, San Francisco County, CA

1. Historic American Buildings Survey San Francisco Chronicle Library Rephoto ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey San Francisco Chronicle Library Re-photo May 1940 TOTALLY DESTROYED - Old U. S. Custom House, Historic View, Battery & Washington Streets, San Francisco, San Francisco County, CA

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, NORTH APPROACH, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, NORTH APPROACH, LOOKING SOUTH. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, NORTH ABUTMENT, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, NORTH ABUTMENT, LOOKING NORTHWEST. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

DETAIL OF NORTH SAN GABRIEL RIVER BRIDGE, PICKET HAND RAIL, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF NORTH SAN GABRIEL RIVER BRIDGE, PICKET HAND RAIL, LOOKING WEST. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

DETAIL OF NORTH SAN GABRIEL RIVER BRIDGE, CANTILEVER SPAN CONNECTION, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF NORTH SAN GABRIEL RIVER BRIDGE, CANTILEVER SPAN CONNECTION, LOOKING SOUTHEAST. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, EAST SIDE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, EAST SIDE, LOOKING SOUTHWEST. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

8. GENERAL VIEW FROM SOUTHEAST (Title Insurance Co. collection, San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. GENERAL VIEW FROM SOUTHEAST (Title Insurance Co. collection, San Diego Historical Society). Historical view, no date, photocopied for HABS, 1975 - Long-Waterman House, 2408 First Avenue, San Diego, San Diego County, CA

1. Historic American Buildings Survey San Francisco Chronicle Photo Undated ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey San Francisco Chronicle Photo Undated (by Taber) ca. 1885 GREENWICH STREET HOUSES (From Powell to Kearny) - Telegraph Hill, Historic View, Greenwich Street, San Francisco, San Francisco County, CA

27 CFR 9.194 - San Antonio Valley.

Code of Federal Regulations, 2010 CFR

2010-04-01

... boundary line of sections 22, 27, and 34, T24S, R10E, to the Monterey-San Luis Obispo County line; then (5) Follow the Monterey-San Luis Obispo County line west for approximately 7.0 miles, back onto the Tierra...

33 CFR 110.74c - Bahia de San Juan, PR.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W. [CGD 7-83-29, 49 FR 48540, Dec. 13, 1984] ...

33 CFR 110.74c - Bahia de San Juan, PR.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bahia de San Juan, PR. 110.74c... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio Channel, Bahia de San Juan, eastward of longitude 66°05′45″ W. [CGD 7-83-29, 49 FR 48540, Dec. 13, 1984] ...

DETAIL OF SOUTH SAN GABRIEL RIVER BRIDGE, CANTILEVER SPAN CONNECTION, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF SOUTH SAN GABRIEL RIVER BRIDGE, CANTILEVER SPAN CONNECTION, LOOKING NORTHWEST. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, RIVER SPAN, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, RIVER SPAN, LOOKING NORTHWEST. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, WEST SIDE, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, WEST SIDE, LOOKING EAST. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, SOUTH ABUTMENT, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, SOUTH ABUTMENT, LOOKING SOUTHWEST. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, SOUTH APPROACH, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, SOUTH APPROACH, LOOKING NORTH. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

DETAIL OF SOUTH SAN GABRIEL RIVER BRIDGE, PICKET HAND RAIL, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL OF SOUTH SAN GABRIEL RIVER BRIDGE, PICKET HAND RAIL, LOOKING WEST. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, FLOOR SYSTEM AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF NORTH SAN GABRIEL RIVER BRIDGE, FLOOR SYSTEM AND LATERAL BRACING, LOOKING SOUTH. - North San Gabriel River Bridge, Spanning North Fork of San Gabriel River at Business Route 35, Georgetown, Williamson County, TX

Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs.

PubMed

Kikuchi, Daisuke; Shibata, Chikashi; Imoto, Hirofumi; Naitoh, Takeshi; Miura, Koh; Unno, Michiaki

2013-08-01

Japanese herbal medicine, also known as Kampo, is used for various diseases in Japan. One of those medicines, Dai-Kenchu-To (DKT), is considered clinically effective for adhesive bowel obstruction and chronic constipation. Although scientific evidence of DKT to improve adhesive bowel obstruction was shown in several previous reports, mechanism of DKT to improve constipation remains unknown. Our aim was to study the effect of intragastric DKT on colonic motility and defecation, and the involvement of various receptors in DKT-induced colonic contractions. Five beagle dogs were instructed with serosal strain-gauge force transducers to measure circular muscle activity at the proximal, middle, and distal colon. Dogs are suitable for a present study to administer the drugs repeatedly to the same individual and look at its effect on colonic motility. We studied the effects of DKT (2.5 or 5 g) administered into the stomach on colonic motility. Muscarinic receptor antagonist atropine, nicotinic receptor antagonist hexamthonium, or 5-hydroxytryptamine-3 receptor antagonist ondansetron was injected intravenously 10 min before DKT administration. Capsazepine, an antagonist to transient receptor potential cation channel subfamily V member 1 (TRPV1), was administered into the stomach 5 min before DKT administration. Intragastric DKT (2.5 or 5 g) induced colonic contractions within 10 min after administration but did not induce defecation. Pretreatment with atropine, hexamthonium, ondansetron, or capsazepine inhibited DKT-induced colonic contractions. These results indicate that orally administered DKT stimulates colonic motility via TRPV1, muscarinic, nicotinic, and 5-hydroxytryptamine-3 receptors, thereby providing scientific support for the efficacy of oral DKT in chronic constipation.

1. Historic American Buildings Survey San Francisco Chronicle Library ca. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey San Francisco Chronicle Library ca. 1865 ORIGINAL SITE - RIGHT FOREGROUND (On Market Street) - Holy Cross Parish Hall, Eddy Street (moved from Market & Second Streets), San Francisco, San Francisco County, CA

78 FR 58878 - Safety Zone; San Diego Shark Fest Swim; San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... this rule because the logistical details of the San Diego Shark Fest Swim were not finalized nor... Local Notice to Mariners and Broadcast Notice to Mariners. D. Regulatory Analyses We developed this rule... analyses based on a number of these statutes and executive orders. 1. Regulatory Planning and Review This...

VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, FLOOR SYSTEM AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW OF SOUTH SAN GABRIEL RIVER BRIDGE, FLOOR SYSTEM AND LATERAL BRACING, LOOKING NORTH. - South San Gabriel River Bridge, Spanning South Fork of San Gabriel River at Georgetown at Business Route 35, Georgetown, Williamson County, TX

1. GENERAL VIEW OF COMPLEX (drawing from History of San ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF COMPLEX (drawing from History of San Diego County, California, published 1883. Photocopy 1975 by Bert Shankland, San Diego). - Johnson-Taylor Ranch House, Black Mountain Road vicinity, Rancho Penasquitos, San Diego County, CA

Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant.

PubMed

Lam, Francis Fu Yuen; Ko, Iris Wai Man; Ng, Ethel Sau Kuen; Tam, Lai Shan; Leung, Ping Chung; Li, Edmund Kwok Ming

2008-10-30

In this study, we have investigated the analgesic and anti-arthritic effects of a traditional Chinese medicine (TCM) combination of Lingzhi and San Miao San (SMS) in a rat model of arthritis induced by Freund's complete adjuvant (FCA). Sprague-Dawley rats were induced with monoarthritis by single unilateral injection of FCA into the knee joint. The TCM combination was administered to the rats daily by intraperitoneal injection (50mg/(kgday)) or via oral administration (500mg/(kgday)) for 7 days before induction of arthritis and 7 days after. Extension angle that provoked struggling behavior, and size and blood flow of the rat knees were measured to give indexes of allodynia, edema, and hyperemia, respectively. The extent of cell infiltration, tissue proliferation, and erosions of joint cartilage provided additional indexes of the arthritis condition. FCA injection produced significant allodynia, edema, hyperemia, immune cell infiltration, synovial tissue proliferation, and erosions of joint cartilage in the ipsilateral knees compared with the contralateral saline-injected knees. Intraperitoneal injection of the TCM combination (50mg/(kgday)) suppressed allodynia, edema, and hyperemia in the inflamed knees, and oral administration (500mg/(kgday)) suppressed edema and hyperemia. Histological examination showed that the TCM administered by either route reduced immune cell infiltration and erosion of joint cartilage. These findings suggest the Lingzhi and SMS formulation has analgesic and anti-inflammatory effects in arthritic rat knees, and concur to previous clinical studies that showed the TCM combination reduced pain in rheumatoid arthritis patients, and extends its possible benefit to suppression of inflammatory symptoms in these patients.

Fault geometry and cumulative offsets in the central Coast Ranges, California: Evidence for northward increasing slip along the San Gregorio-San Simeon-Hosgri fault

USGS Publications Warehouse

Langenheim, V.E.; Jachens, R.C.; Graymer, R.W.; Colgan, J.P.; Wentworth, C.M.; Stanley, R.G.

2012-01-01

Estimates of the dip, depth extent, and amount of cumulative displacement along the major faults in the central California Coast Ranges are controversial. We use detailed aeromagnetic data to estimate these parameters for the San Gregorio–San Simeon–Hosgri and other faults. The recently acquired aeromagnetic data provide an areally consistent data set that crosses the onshore-offshore transition without disruption, which is particularly important for the mostly offshore San Gregorio–San Simeon–Hosgri fault. Our modeling, constrained by exposed geology and in some cases, drill-hole and seismic-reflection data, indicates that the San Gregorio–San Simeon–Hosgri and Reliz-Rinconada faults dip steeply throughout the seismogenic crust. Deviations from steep dips may result from local fault interactions, transfer of slip between faults, or overprinting by transpression since the late Miocene. Given that such faults are consistent with predominantly strike-slip displacement, we correlate geophysical anomalies offset by these faults to estimate cumulative displacements. We find a northward increase in right-lateral displacement along the San Gregorio–San Simeon–Hosgri fault that is mimicked by Quaternary slip rates. Although overall slip rates have decreased over the lifetime of the fault, the pattern of slip has not changed. Northward increase in right-lateral displacement is balanced in part by slip added by faults, such as the Reliz-Rinconada, Oceanic–West Huasna, and (speculatively) Santa Ynez River faults to the east.

The San Dimas experimental forest: 50 years of research

Treesearch

Paul H. Dunn; Susan C. Barro; Wade G. Wells; Mark A Poth; Peter M. Wohlgemuth; Charles G. Colver

1988-01-01

The San Dimas Experimental Forest serves as a field laboratory for studies of chaparral and related ecosystems, and has been recognized by national and international organizations. It covers 6,945 ha (17,153 acres) in the foothills of the San Gabriel Mountains northeast of Los Angeles, and has a typical Mediterranean-type climate. The Forest encompasses the San Dimas...

33 CFR 110.120 - San Luis Obispo Bay, Calif.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, Calif. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.120 San Luis Obispo Bay, Calif. (a) Area A-1. Area A-1 is the water area bounded by the San Luis Obispo County wharf, the shoreline, a line drawn...

40 CFR 81.164 - San Diego Intrastate Air Quality Control Region.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 18 2012-07-01 2012-07-01 false San Diego Intrastate Air Quality... Quality Control Regions § 81.164 San Diego Intrastate Air Quality Control Region. The San Diego Intrastate... within the outermost boundaries of the area so delimited): In the State of California: San Diego County...

40 CFR 81.164 - San Diego Intrastate Air Quality Control Region.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 18 2014-07-01 2014-07-01 false San Diego Intrastate Air Quality... Quality Control Regions § 81.164 San Diego Intrastate Air Quality Control Region. The San Diego Intrastate... within the outermost boundaries of the area so delimited): In the State of California: San Diego County...

40 CFR 81.164 - San Diego Intrastate Air Quality Control Region.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 18 2013-07-01 2013-07-01 false San Diego Intrastate Air Quality... Quality Control Regions § 81.164 San Diego Intrastate Air Quality Control Region. The San Diego Intrastate... within the outermost boundaries of the area so delimited): In the State of California: San Diego County...

40 CFR 81.164 - San Diego Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false San Diego Intrastate Air Quality... Quality Control Regions § 81.164 San Diego Intrastate Air Quality Control Region. The San Diego Intrastate... within the outermost boundaries of the area so delimited): In the State of California: San Diego County...

40 CFR 81.164 - San Diego Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 17 2011-07-01 2011-07-01 false San Diego Intrastate Air Quality... Quality Control Regions § 81.164 San Diego Intrastate Air Quality Control Region. The San Diego Intrastate... within the outermost boundaries of the area so delimited): In the State of California: San Diego County...

Pharmacokinetic interactions of herbal medicines for the treatment of chronic hepatitis.

PubMed

Hsueh, Tun-Pin; Lin, Wan-Ling; Tsai, Tung-Hu

2017-04-01

Chronic liver disease is a serious global health problem, and an increasing number of patients are seeking alternative medicines or complementary treatment. Herbal medicines account for 16.8% of patients with chronic liver disease who use complementary and alternative therapies. A survey of the National Health Insurance Research Database in Taiwan reported that Long-Dan-Xie-Gan-Tang, Jia-Wei-Xia-Yao-San, and Xiao-Chai-Hu-Tang (Sho-saiko-to) were the most frequent formula prescriptions for chronic hepatitis used by traditional Chinese medicine physicians. Bioanalytical methods of herbal medicines for the treatment of chronic hepatitis were developed to investigate pharmacokinetics properties, but multicomponent herbal formulas have been seldom discussed. The pharmacokinetics of herbal formulas is closely related to efficacy, efficiency, and patient safety of traditional herbal medicines. Potential herbal formula-drug interactions are another essential issue during herbal formula administration in chronic hepatitis patients. In a survey with the PubMed database, this review article evaluates the existing evidence-based data associated with the documented pharmacokinetics profiles and potential herbal-drug interactions of herbal formulas for the treatment of chronic hepatitis. In addition, the existing pharmacokinetic profiles were further linked with clinical practice to provide insight for the safety and specific use of traditional herbal medicines. Copyright © 2016. Published by Elsevier B.V.

The San Francisco Consortium; An Educational Association for Urban Affairs. Progress Report.

ERIC Educational Resources Information Center

San Francisco Consortium, CA.

The San Francisco Consortium was formed in the Fall of 1967 by 5 institutions: City College of San Francisco, Golden Gate College, San Francisco State College, University of California-San Francisco Medical Center and the University of San Francisco. Its primary purpose is to be the instrument through which the resources of the major local…

The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study.

PubMed

Lin, Yi-Rong; Wu, Mei-Yao; Chiang, Jen-Huai; Yen, Hung-Rong; Yang, Su-Tso

2017-08-29

Many patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan. We analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626.8) from January 1, 1997 to December 31, 2010. The patients were categorized into TCM seekers and non-TCM seekers according to their use of TCM. Among the subjects, 41,558 (89.69%) were TCM seekers and 4,779 (10.31%) were non-TCM seekers. Patients who were younger tended to be TCM seekers. Most of the patients had also taken Western medicine, especially tranexamic acid and non-steroidal anti-inflammatory drugs (NSAIDs). More than half of TCM seekers (55.41%) received combined treatment with both Chinese herbal remedies and acupuncture. The most commonly used TCM formula and single herb were Jia-Wei-Xiao-Yao-San (Bupleurum and Peony Formula) and Yi-Mu-Cao (Herba Leonuri), respectively. The core pattern of Chinese herbal medicine for DUB patients consisted of Jia-Wei-Xiao-Yao-San, Xiang-Fu (Rhizoma Cyperi), and Yi-Mu-Cao (Herba Leonuri). TCM use is popular among patients with DUB in Taiwan. Further pharmacological investigations and clinical trials are required to validate the efficacy and safety of these items.

Medicinal Cannabis in California: An Interview with Igor Grant, MD.

PubMed

Piomelli, Daniele; Grant, Igor

2016-01-01

Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research at the University of California, San Diego. Dr. Grant is a neuropsychiatrist who graduated from the University of British Columbia School of Medicine (1966), and received specialty training in psychiatry at the University of Pennsylvania (1967-1971), and additional training in neurology at the Institute of Neurology (1980-1981), London, U.K. Dr. Grant's academic interests focus on the effects of various diseases on brain and behavior, with an emphasis on translational studies in HIV, and drugs of abuse. He has contributed to ∼700 scholarly publications and is principal investigator of several NIH studies, including an NIDA P50 (Translational Methamphetamine AIDS Research Center-TMARC), and is codirector of the HIV Neurobehavioral Research Center (HNRC).

Holocene Geologic Slip Rate for the Banning Strand of the Southern San Andreas Fault near San Gorgonio Pass, Southern California

NASA Astrophysics Data System (ADS)

Gold, P. O.; Behr, W. M.; Rood, D. H.; Kendrick, K. J.; Rockwell, T. K.; Sharp, W. D.

2014-12-01

We present the first Holocene geologic slip rate for the Banning strand of the southern San Andreas Fault in southern California. The southern San Andreas Fault splays into the sub-parallel Banning and Mission Creek strands in the northwestern Coachella Valley, and although it has long been surmised that the Banning strand eventually accommodates the majority of displacement and transfers it into San Gorgonio Pass, until now it has been uncertain how slip is actually partitioned between these two fault strands. Our new slip rate measurement, critically located at the northwestern end of the Banning strand, overlaps within errors with the published rate for the southern San Andreas Fault measured at Biskra Palms Oasis. This indicates that the majority of southern San Andreas Fault displacement transfers from the southeastern Mission Creek strand northwest to the Banning strand and into San Gorgonio Pass. Our result corroborates the UCERF3 hazard model, and is consistent with most previous interpretations of how slip is partitioned between the Banning and Mission Creek fault strands. To measure this slip rate, we used B4 airborne LiDAR to identify the apex of an alluvial fan offset laterally 30 ± 5 m from its source. We calculated the depositional age of the fan using 10Be in-situ cosmogenic exposure dating of 5 cobbles and a depth profile. We calculated a most probable fan age of 4.0 +2.0/-1.6 ka (1σ) by combining the inheritance-corrected cobble ages assuming Gaussian uncertainty. However, the probability density function yielded a multi-peaked distribution, which we attribute to variable 10Be inheritance in the cobbles, so we favor the depth profile age of 2.2-3.6 ka. Combined, these measurements yield a late Holocene slip rate for the Banning strand of the southern San Andreas Fault of 11.1 +3.1/-3.3 mm/yr. This slip rate does not preclude possibility that some slip transfers north along the Mission Creek strand and the Garnet Hill fault, but it does confirm

SAN FRANCISCO BAY WETLANDS REGIONAL MONITORING PROGRAM

EPA Science Inventory

The geographic area to be monitored is the San Francisco Estuary and its watersheds from the Golden Gate to the Sacramento-San Joaquin Delta at Broad Slough. The initial focus will be the baylands of the region defined as the lands between the maximum and minimum elevations of t...

Unraveling the Alteration History of Serpentinites and Associated Ultramafic Rocks from the Kampos HPLT Subduction Complex, Syros, Greece

NASA Astrophysics Data System (ADS)

Cooperdock, E. H. G.; Stockli, D. F.

2016-12-01

Serpentinization, hydration of peridotite, has a profound effect on fundamental tectonic and petrologic processes such as deformation of the lithosphere, bulk rheology, fluid-mobile element cycling and deep earth carbon cycling. Though numerous studies have investigated the petrology, structure and geochemistry of serpentinites, the absolute chronology of serpentinization remains elusive due to a lack of accessory minerals that can be dated using established geochronological techniques. Magnetite forms as a common secondary mineral in serpentinites from the fluid-induced breakdown reaction of primary peridotite minerals. Magnetite (U-Th)/He chronometry provides the potential to directly date the cooling of exhumed ultramafic bodies and the low-temperature fluid alteration of serpentinites. We present the first application of magnetite (U-Th)/He chronometry to date stages of alteration in ultramafic rocks from the Kampos mélange belt, a high-pressure low-temperature (HP-LT) subduction complex that experienced exhumation in the Miocene on the island of Syros, Greece. Two generations of magnetite are distinguishable by grain size, magnetite trace element geochemistry and (U-Th)/He age. Large magnetite grains (mm) from a chlorite schist and a serpentinite schist have distinct geochemical signatures indicative of formation during blackwall-related fluid alteration and record Mid-Miocene exhumation-related cooling ages, similar to zircon (U-Th)/He ages from northern Syros. Smaller grains (µm) from the serpentinite schist lack blackwall-related fluid signatures and record post-exhumation mineral formation associated with widespread high-angle Pliocene normal faulting. These results reveal evidence for multiple episodes of fluid-rock alteration, which has implications for the cooling history and local geochemical exchanges of this HP-LT terrane. Given the fundamental impact of serpentinizaton on a vast array of tectonic, petrological, and geochemical processes, the

75 FR 55975 - Safety Zone; San Diego Harbor Shark Fest Swim; San Diego Bay, San Diego, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... Guard did not receive notification of the logistical details of the San Diego Bay swim in sufficient... the Captain of the Port, or designated representative. Regulatory Analyses We developed this rule... analyses based on 13 of these statutes or executive orders. Regulatory Planning and Review This rule is not...

Radar image San Francisco Bay Area, California

NASA Technical Reports Server (NTRS)

2000-01-01

The San Francisco Bay Area in California and its surroundings are shown in this radar image from the Shuttle Radar Topography Mission (SRTM). On this image, smooth areas, such as the bay, lakes, roads and airport runways appear dark, while areas with buildings and trees appear bright. Downtown San Francisco is at the center and the city of Oakland is at the right across the San Francisco Bay. Some city areas, such as the South of Market district in San Francisco, appear bright due to the alignment of streets and buildings with respect to the incoming radar beam. Three of the bridges spanning the Bay are seen in this image. The Bay Bridge is in the center and extends from the city of San Francisco to Yerba Buena and Treasure Islands, and from there to Oakland. The Golden Gate Bridge is to the left and extends from San Francisco to Sausalito. The Richmond-San Rafael Bridge is in the upper right and extends from San Rafael to Richmond. Angel Island is the large island east of the Golden Gate Bridge, and lies north of the much smaller Alcatraz Island. The Alameda Naval Air Station is seen just below the Bay Bridge at the center of the image. Two major faults bounding the San Francisco-Oakland urban areas are visible on this image. The San Andreas fault, on the San Francisco peninsula, is seen on the left side of the image. The fault trace is the straight feature filled with linear reservoirs, which appear dark. The Hayward fault is the straight feature on the right side of the image between the urban areas and the hillier terrain to the east.

This radar image was acquired by just one of SRTM's two antennas and, consequently, does not show topographic data, but only the strength of the radar signal reflected from the ground. This signal, known as radar backscatter, provides insight into the nature of the surface, including its roughness, vegetation cover and urbanization. The overall faint striping pattern in the images is a data processing artifact due to the

CIRSS vertical data integration, San Bernardino study

NASA Technical Reports Server (NTRS)

Hodson, W.; Christenson, J.; Michel, R. (Principal Investigator)

1982-01-01

The creation and use of a vertically integrated data base, including LANDSAT data, for local planning purposes in a portion of San Bernardino County, California are described. The project illustrates that a vertically integrated approach can benefit local users, can be used to identify and rectify discrepancies in various data sources, and that the LANDSAT component can be effectively used to identify change, perform initial capability/suitability modeling, update existing data, and refine existing data in a geographic information system. Local analyses were developed which produced data of value to planners in the San Bernardino County Planning Department and the San Bernardino National Forest staff.

Long Return Periods for Earthquakes in San Gorgonio Pass and Implications for Large Ruptures of the San Andreas Fault in Southern California

NASA Astrophysics Data System (ADS)

Yule, J.; McBurnett, P.; Ramzan, S.

2011-12-01

The largest discontinuity in the surface trace of the San Andreas fault occurs in southern California at San Gorgonio Pass. Here, San Andreas motion moves through a 20 km-wide compressive stepover on the dextral-oblique-slip thrust system known as the San Gorgonio Pass fault zone. This thrust-dominated system is thought to rupture during very large San Andreas events that also involve strike-slip fault segments north and south of the Pass region. A wealth of paleoseismic data document that the San Andreas fault segments on either side of the Pass, in the San Bernardino/Mojave Desert and Coachella Valley regions, rupture on average every ~100 yrs and ~200 yrs, respectively. In contrast, we report here a notably longer return period for ruptures of the San Gorgonio Pass fault zone. For example, features exposed in trenches at the Cabezon site reveal that the most recent earthquake occurred 600-700 yrs ago (this and other ages reported here are constrained by C-14 calibrated ages from charcoal). The rupture at Cabezon broke a 10 m-wide zone of east-west striking thrusts and produced a >2 m-high scarp. Slip during this event is estimated to be >4.5 m. Evidence for a penultimate event was not uncovered but presumably lies beneath ~1000 yr-old strata at the base of the trenches. In Millard Canyon, 5 km to the west of Cabezon, the San Gorgonio Pass fault zone splits into two splays. The northern splay is expressed by 2.5 ± 0.7 m and 5.0 ± 0.7 m scarps in alluvial terraces constrained to be ~1300 and ~2500 yrs old, respectively. The scarp on the younger, low terrace postdates terrace abandonment ~1300 yrs ago and probably correlates with the 600-700 yr-old event at Cabezon, though we cannot rule out that a different event produced the northern Millard scarp. Trenches excavated in the low terrace reveal growth folding and secondary faulting and clear evidence for a penultimate event ~1350-1450 yrs ago, during alluvial deposition prior to the abandonment of the low terrace

South San Francisco Bay, California

USGS Publications Warehouse

Dartnell, Peter; Gibbons, Helen

2007-01-01

View eastward. Elevations in mapped area color coded: purple (approx 15 m below sea level) to red-orange (approx 90 m above sea level). South San Francisco Bay is very shallow, with a mean water depth of 2.7 m (8.9 ft). Trapezoidal depression near San Mateo Bridge is where sediment has been extracted for use in cement production and as bay fill. Land from USGS digital orthophotographs (DOQs) overlaid on USGS digital elevation models (DEMs). Distance across bottom of image approx 11 km (7 mi); vertical exaggeration 1.5X.

Fragmented Landscapes in the San Gorgonio Pass Region: Insights into Quaternary Strain History of the Southern San Andreas Fault System

NASA Astrophysics Data System (ADS)

Kendrick, K. J.; Matti, J. C.; Landis, G. P.; Alvarez, R. M.

2006-12-01

The San Gorgonio Pass (SGP) region is a zone of structural complexity within the southern San Andreas Fault system that is characterized by (1) multiple strands of the San Andreas Fault (SAF), (2) intense and diverse microseismicity, (3) contraction within the SGP fault zone (SGPfz), and (4) complex and diverse landforms - all a consequence of structural complications in the vicinity of the southeastern San Bernardino Mountains (SBM). Multiple strands of the SAF zone in the SGP region partition the landscape into discrete geomorphic/geologic domains, including: San Gorgonio Mountain (SGM), Yucaipa Ridge (YR), Kitching Peak (KP), Pisgah Peak (PP), and Coachella Valley (CV) domains. The morphology of each domain reflects the tectonic history unique to that region. Development of the SGP knot in the Mission Creek strand of the SAF (SAFmi) led to westward deflection of the SAFmi, juxtaposition of the KP, PP, and SGM domains, initiation of uplift of YR domain along thrust faults in headwaters of San Gorgonio River, and development of the San Jacinto Fault. Slip on the SAF diminished as a result, thereby allowing integrated drainage systems to develop in the greater SGP region. San Gorgonio River, Whitewater River, and Mission Creek are discrete drainages that transport sediment across the SGM, YR, PP, KP, and CV domains into alluvial systems peripheral to the SGP region. There, depositional units (San Timoteo Formation, upper member, deformed gravels of Whitewater River) all contain clasts of SBM-type and San Gabriel Mountain-type basement, thus constraining slip on the SAF in the SGP region. Middle and late Pleistocene slip on the Mill Creek strand of the SAF (SAFm) in the SGP region has attempted to bypass the SGP knot, and has disrupted landscapes established during SAFmi quiescence. Restoration of right-slip on the SAFm is key to deciphering landscape history. Matti and others (1985, 1992) proposed that a bi-lobed alluvial deposit in the Raywood Flats area has been

76 FR 70480 - Otay River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National Wildlife...), intend to prepare an environmental impact statement (EIS) for the proposed Otay River Estuary Restoration... any one of the following methods. Email: [email protected] . Please include ``Otay Estuary NOI'' in the...

Holocene deceleration of the San Andreas fault zone in San Bernardino and implications for the eastern California shear zone rate debate

NASA Astrophysics Data System (ADS)

Bennett, R. A.; Lavier, L.; Anderson, M. L.; Matti, J.; Powell, R. E.

2005-05-01

New geodetic inferences for the rate of strain accumulation on the San Andreas fault associated with tectonic loading are ~20 mm/yr slower than observed Holocene surface displacement rates in the San Bernardino area, south of the fault's intersection with the San Jacinto fault zone, and north of its intersection with the eastern California shear zone (ECSZ). This displacement rate "anomaly" is significantly larger than can be easily explained by locking depth errors or earthquake cycle effects not accounted for in geodesy-constrained models for elastic loading rate. Using available time-averaged fault displacement-rates for the San Andreas and San Jacinto fault zones, we estimate instantaneous time-variable displacement rates on the San Andreas-San Jacinto-ECSZ fault zones, assuming that these fault zones form a closed system in the latitude band along which the fault zones overlap with one another and share in the accommodation of steady Pacific-North America relative plate motion. We find that the Holocene decrease in San Andreas loading rate can be compensated by a rapid increase in loading/displacement rate within the ECSZ over the past ~5 kyrs, independent of, but consistent with geodetic and geologic constraints derived from the ECSZ itself. Based on this model, we suggest that reported differences between fast contemporary strain rates observed on faults of the ECSZ using geodesy and slow rates inferred from Quaternary geology and Holocene paleoseismology (i.e., the ECSZ rate debate) may be explained by rapid changes in the pattern and rates of strain accumulation associated with fault loading largely unrelated to postseismic stress relaxation. If so, displacement rate data sets from Holocene geology and present-day geodesy could potentially provide important new constraints on the rheology of the lower crust and upper mantle representing lithospheric behavior on time-scales of thousands of years. Moreover, the results underscore that disagreement between

Backwater Flooding in San Marcos, TX from the Blanco River

NASA Technical Reports Server (NTRS)

Earl, Richard; Gaenzle, Kyle G.; Hollier, Andi B.

2016-01-01

Large sections of San Marcos, TX were flooded in Oct. 1998, May 2015, and Oct. 2015. Much of the flooding in Oct. 1998 and Oct. 2015 was produced by overbank flooding of San Marcos River and its tributaries by spills from upstream dams. The May 2015 flooding was almost entirely produced by backwater flooding from the Blanco River whose confluence is approximately 2.2 miles southeast of downtown. We use the stage height of the Blanco River to generate maps of the areas of San Marcos that are lower than the flood peaks and compare those results with data for the observed extent of flooding in San Marcos. Our preliminary results suggest that the flooding occurred at locations more than 20 feet lower than the maximum stage height of the Blanco River at San Marcos gage (08171350). This suggest that the datum for either gage 08171350 or 08170500 (San Marcos River at San Marcos) or both are incorrect. There are plans for the U.S. Army Corps of Engineers to construct a Blanco River bypass that will divert Blanco River floodwaters approximately 2 miles farther downstream, but the $60 million price makes its implementation problematic.

NREL, San Diego Gas & Electric Are Advancing Utility Microgrid Performance

Science.gov Websites

in Borrego Springs, California | Energy Systems Integration Facility | NREL NREL, San Diego Gas & Electric Models Utility Microgrid in Borrego Springs NREL, San Diego Gas & Electric Are Advancing Utility Microgrid Performance in Borrego Springs, California San Diego Gas & Electric Company

Environmental setting of the San Joaquin-Tulare basins, California

USGS Publications Warehouse

Gronberg, JoAnn A.; Dubrovsky, Neil M.; Kratzer, Charles R.; Domagalski, Joseph L.; Brown, Larry R.; Burow, Karen R.

1998-01-01

The National Water-Quality Assessment Program for the San Joaquin- Tulare Basins began in 1991 to study the effects of natural and anthropogenic influences on the quality of ground water, surface water, biology, and ecology. The San Joaquin-Tulare Basins study unit, which covers approximately 31,200 square miles in central California, is made up of the San Joaquin Valley, the eastern slope of the Coast Ranges to the west, and the western slope of the Sierra Nevada to the east. The sediments of the San Joaquin Valley can be divided into alluvial fans and basin deposits. The San Joaquin River receives water from tributaries draining the Sierra Nevada and Coast Ranges, and except for streams discharging directly to the Sacramento-San Joaquin Delta, is the only surface- water outlet from the study unit. The surface-water hydrology of the San Joaquin-Tulare Basins study unit has been significantly modified by development of water resources. Almost every major river entering the valley from the Sierra Nevada has one or more reservoirs. Almost every tributary and drainage into the San Joaquin River has been altered by a network of canals, drains, and wasteways. The Sierra Nevada is predominantly forested, and the Coast Ranges and the foothills of the Sierra Nevada are predominately rangeland. The San Joaquin Valley is dominated by agriculture, which utilized approximately 14.7 million acre-feet of water and 597 million pounds active ingredient of nitrogen and phosphorus fertilizers in 1990, and 88 million pounds active ingredient of pesticides in 1991. In addition, the livestock industry contributed 318 million pounds active ingredient of nitrogen and phosphorus from manure in 1987. This report provides the background information to assess the influence of these and other factors on water quality and to provide the foundation for the design and interpretation of all spatial data. These characterizations provide a basis for comparing the influences of human activities

12. Historic American Buildings Survey S.F. Chronicle Library, San Francisco ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey S.F. Chronicle Library, San Francisco BUILT 1853 - '4 AFTER THE DISASTER OF 1906 - St. Mary's Church, 660 California Street, San Francisco, San Francisco County, CA

Lahar-hazard zonation for San Miguel volcano, El Salvador

USGS Publications Warehouse

Major, J.J.; Schilling, S.P.; Pullinger, C.R.; Escobar, C.D.; Chesner, C.A.; Howell, M.M.

2001-01-01

San Miguel volcano, also known as Chaparrastique, is one of many volcanoes along the volcanic arc in El Salvador. The volcano, located in the eastern part of the country, rises to an altitude of about 2130 meters and towers above the communities of San Miguel, El Transito, San Rafael Oriente, and San Jorge. In addition to the larger communities that surround the volcano, several smaller communities and coffee plantations are located on or around the flanks of the volcano, and the PanAmerican and coastal highways cross the lowermost northern and southern flanks of the volcano. The population density around San Miguel volcano coupled with the proximity of major transportation routes increases the risk that even small volcano-related events, like landslides or eruptions, may have significant impact on people and infrastructure. San Miguel volcano is one of the most active volcanoes in El Salvador; it has erupted at least 29 times since 1699. Historical eruptions of the volcano consisted mainly of relatively quiescent emplacement of lava flows or minor explosions that generated modest tephra falls (erupted fragments of microscopic ash to meter sized blocks that are dispersed into the atmosphere and fall to the ground). Little is known, however, about prehistoric eruptions of the volcano. Chemical analyses of prehistoric lava flows and thin tephra falls from San Miguel volcano indicate that the volcano is composed dominantly of basalt (rock having silica content

San Antonio, Texas as seen from STS-58

NASA Image and Video Library

1993-10-30

STS058-101-053 (18 Oct-1 Nov 1993) --- This sharp cloud-free photograph of San Antonio, Texas illustrates the classic pattern of western cities. The Hispanic heart of the city; an intertwining of streets along the San Antonio River and around the Alamo, surrounded by a late 19th century Anglo grid of small businesses and suburban homes. Transportation routes radiate to mid and late 20th Century ring corridors separating the urban/suburban region from the surrounding agricultural countryside. San Antonio was founded around permanent springs that rise at the foot of the Balcones Escarpment, which separates the Texas Hill Country from the South Texas Plains. Limestone quarries are conspicuous along the edge of the escarpment. San Antonio has long been a major site for military training bases: Randolph Air Force Base is outside the city to the northeast, Fort Sam Houston is contained within the northeast quadrant of the city, Brooks Air Force Base lies at the southeastern corner, and Lackland and Kelly Air Force Bases are within the suburban fringe to the southwest. San Antonio International Airport can be seen at the foot of the escarpment in the northern part of the city.

Children and the San Fernando earthquake

USGS Publications Warehouse

Howard, S. J.

1980-01-01

Before dawn, on February 9, 1971, a magnitude 6.4 earthquake occurred in the San Fernando Valley of California. On the following day, theSan Fernando Valley Child Guidance Clinic, through radio and newspapers, offered mental health crises services to children frightened by the earthquake. Response to this invitation was immediate and almost overwhelming. During the first 2 weeks, the Clinic's staff counseled hundreds of children who were experiencing various degrees of anxiety. 

San Francisco urban partnership agreement : national evaluation plan.

DOT National Transportation Integrated Search

2009-12-22

This report provides an analytic framework for evaluating the San Francisco Urban Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. The San Francisco UPA projects to be evaluated focus on those r...

High-resolution marine seismic reflection data from the San Francisco Bay area

USGS Publications Warehouse

Childs, Jonathan R.; Hart, Patrick; Bruns, Terry R.; Marlow, Michael S.; Sliter, Ray

2000-01-01

Between 1993 and 1997, the U.S. Geological Survey acquired high-resolution, marine seismic-reflection profile data across submerged portions of known and inferred upper crustal fault zones throughout the greater San Francisco Bay area. Surveys were conducted oversouth San Francisco Bay in the vicinity of the San Bruno shoal (roughly between the San Francisco and Oakland airports), over the offshore extension of the San Andreas fault system west of the Golden Gate, over the Hayward fault to Rodgers Creek fault step-over in San Pablo Bay, and over the Kirby Hills fault where it crosses the western Sacramento Delta. Reconnaissance profiles were acquired elsewhere throughout the San Francisco and San Pablo Bays. These data were acquired by the U.S. Geological Survey, Western Coastal and Marine Geology Team, under the auspices of the Central California/San Francisco Bay Earthquake Hazards Project. Analysis and interpretation of some of these profiles has been published by Marlow and others (1996, 1999). Further analysis and interpretation of these data are available in a USGS. Professional Paper Crustal Structure of the Coastal and Marine San Francisco Bay Region, T. Parsons, editor, http://geopubs.wr.usgs.gov/prof-paper/pp1658/ [link added 2012 mfd].

Cacao use and the San Lorenzo Olmec.

PubMed

Powis, Terry G; Cyphers, Ann; Gaikwad, Nilesh W; Grivetti, Louis; Cheong, Kong

2011-05-24

Mesoamerican peoples had a long history of cacao use--spanning more than 34 centuries--as confirmed by previous identification of cacao residues on archaeological pottery from Paso de la Amada on the Pacific Coast and the Olmec site of El Manatí on the Gulf Coast. Until now, comparable evidence from San Lorenzo, the premier Olmec capital, was lacking. The present study of theobromine residues confirms the continuous presence and use of cacao products at San Lorenzo between 1800 and 1000 BCE, and documents assorted vessels forms used in its preparation and consumption. One elite context reveals cacao use as part of a mortuary ritual for sacrificial victims, an event that occurred during the height of San Lorenzo's power.

Holocene slip rates along the San Andreas Fault System in the San Gorgonio Pass and implications for large earthquakes in southern California

NASA Astrophysics Data System (ADS)

Heermance, Richard V.; Yule, Doug

2017-06-01

The San Gorgonio Pass (SGP) in southern California contains a 40 km long region of structural complexity where the San Andreas Fault (SAF) bifurcates into a series of oblique-slip faults with unknown slip history. We combine new 10Be exposure ages (Qt4: 8600 (+2100, -2200) and Qt3: 5700 (+1400, -1900) years B.P.) and a radiocarbon age (1260 ± 60 years B.P.) from late Holocene terraces with scarp displacement of these surfaces to document a Holocene slip rate of 5.7 (+2.7, -1.5) mm/yr combined across two faults. Our preferred slip rate is 37-49% of the average slip rates along the SAF outside the SGP (i.e., Coachella Valley and San Bernardino sections) and implies that strain is transferred off the SAF in this area. Earthquakes here most likely occur in very large, throughgoing SAF events at a lower recurrence than elsewhere on the SAF, so that only approximately one third of SAF ruptures penetrate or originate in the pass.