Sample records for kappa-725 resonances

  1. 12 CFR 725.8-725.16 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false [Reserved] 725.8-725.16 Section 725.8-725.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY §§ 725.8-725.16 [Reserved] ...

  2. A new assay format for NF-kappaB based on a DNA triple helix and a fluorescence resonance energy transfer.

    PubMed

    Altevogt, Dominik; Hrenn, Andrea; Kern, Claudia; Clima, Lilia; Bannwarth, Willi; Merfort, Irmgard

    2009-10-07

    Herein we report a feasibility study for a new concept to detect DNA binding protein NF-kappaB based on a DNA triple helix formation in combination with a fluorescence resonance energy transfer (FRET). The new principle avoids expensive antibodies and radioactivity and might have implications for assays of other DNA binding proteins.

  3. 10 CFR 725.21 - Issuance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Issuance. 725.21 Section 725.21 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.21 Issuance. (a) Upon a determination that an... receive Restricted Data. See § 725.24 and part 1016 of this title. [41 FR 56778, Dec. 30, 1976, as amended...

  4. 10 CFR 725.21 - Issuance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Issuance. 725.21 Section 725.21 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.21 Issuance. (a) Upon a determination that an... receive Restricted Data. See § 725.24 and part 1016 of this title. [41 FR 56778, Dec. 30, 1976, as amended...

  5. 40 CFR 725.70 - Compliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Compliance. 725.70 Section 725.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.70 Compliance. (a) Failure...

  6. 40 CFR 725.70 - Compliance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Compliance. 725.70 Section 725.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.70 Compliance. (a) Failure...

  7. 18 CFR 725.3 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Applicability. 725.3 Section 725.3 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.3...

  8. Bioluminescence resonance energy transfer (BRET) to detect the interactions between kappa opioid receptor and non visual arrestins.

    PubMed

    Bedini, Andrea

    2015-01-01

    Bioluminescence resonance energy transfer (BRET) is a very sensitive technique employed to study protein-protein interactions, including G-protein-coupled receptors (GPCRs) hetero- and homo-dimerization. Recently, BRET has also been used to investigate the interaction between GPCRs (e.g., β2 adrenergic receptor, muscarinic M2 receptor, dopaminergic D2 receptor) and non-visual arrestins. Here a BRET protocol is described to investigate interactions between the kappa opioid receptor (KOR) and non visual arrestins (arrestin-2 and arrestin-3) in HEK-293 cells, both under basal conditions and after exposure to KOR ligands.

  9. 10 CFR 72.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 72.5 Section 72.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions § 72.5...

  10. 10 CFR 72.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 72.5 Section 72.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions § 72.5...

  11. 18 CFR 725.2 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Policy. 725.2 Section 725.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.2 Policy. It is...

  12. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer, HS-1...

  13. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer, HS-1...

  14. 30 CFR 725.24 - Records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Records. 725.24 Section 725.24 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.24 Records. (a) The agency shall maintain complete records in accordance with Office of Management and Budget Circular No. A-102. This includes books, records, documents...

  15. 30 CFR 725.24 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Records. 725.24 Section 725.24 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.24 Records. (a) The agency shall maintain complete records in accordance with Office of Management and Budget Circular No. A-102. This includes books, records, documents...

  16. 30 CFR 725.24 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Records. 725.24 Section 725.24 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.24 Records. (a) The agency shall maintain complete records in accordance with Office of Management and Budget Circular No. A-102. This includes books, records, documents...

  17. 30 CFR 725.24 - Records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Records. 725.24 Section 725.24 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.24 Records. (a) The agency shall maintain complete records in accordance with Office of Management and Budget Circular No. A-102. This includes books, records, documents...

  18. 10 CFR 725.24 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... designate a DOE or National Nuclear Security Administration office which will: (a) Process all personnel...

  19. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer, HS-1...

  20. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer, HS-1...

  1. 10 CFR 725.24 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... designate a DOE or National Nuclear Security Administration office which will: (a) Process all personnel...

  2. 10 CFR 725.24 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... designate a DOE or National Nuclear Security Administration office which will: (a) Process all personnel...

  3. 10 CFR 725.24 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... designate a DOE or National Nuclear Security Administration office which will: (a) Process all personnel...

  4. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer, HS-1...

  5. 32 CFR 725.2 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Policy. 725.2 Section 725.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL RELEASE OF OFFICIAL INFORMATION FOR LITIGATION PURPOSES AND TESTIMONY BY DEPARTMENT OF THE NAVY PERSONNEL § 725.2 Policy. (a) It is DON policy...

  6. 10 CFR 725.24 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Administration. 725.24 Section 725.24 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Permits § 725.24 Administration. With respect to each permit... Applicant, in accordance with part 1016 of this title, for the safeguarding of Restricted Data; and (c...

  7. 30 CFR 725.23 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Reports. 725.23 Section 725.23 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.23 Reports. (a) The agency shall, for each grant made under this part, submit semiannually to the Director or his authorized designee a Financial Status Report, SF 269...

  8. 20 CFR 725.621 - Reports.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Reports. 725.621 Section 725.621 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.621 Reports. (a) Upon making the first... pertinent. (c) The Director may from time to time prescribe such additional reports to be made by operators...

  9. 20 CFR 725.621 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Reports. 725.621 Section 725.621 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.621 Reports. (a) Upon making the first... pertinent. (c) The Director may from time to time prescribe such additional reports to be made by operators...

  10. 20 CFR 725.608 - Interest.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Interest. 725.608 Section 725.608 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.608 Interest. (a)(1) In any case in which... simple annual interest, computed from the date on which the benefits were due. The interest shall be...

  11. 20 CFR 725.608 - Interest.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Interest. 725.608 Section 725.608 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.608 Interest. (a)(1) In any case in which... simple annual interest, computed from the date on which the benefits were due. The interest shall be...

  12. 20 CFR 725.608 - Interest.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Interest. 725.608 Section 725.608 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.608 Interest. (a)(1) In any case in which... simple annual interest, computed from the date on which the benefits were due. The interest shall be...

  13. 20 CFR 725.608 - Interest.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Interest. 725.608 Section 725.608 Employees... HEALTH ACT, AS AMENDED Enforcement of Liability; Reports § 725.608 Interest. (a)(1) In any case in which... simple annual interest, computed from the date on which the benefits were due. The interest shall be...

  14. 30 CFR 725.19 - Audit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Audit. 725.19 Section 725.19 Mineral Resources... REGULATIONS REIMBURSEMENTS TO STATES § 725.19 Audit. The agency shall arrange for an independent audit no less... Circular No. A-102, Attachment P. The audits will be performed in accordance with the “Standards for Audit...

  15. 30 CFR 725.22 - Financial management.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... An agency shall use generally accepted accounting principles and practices, consistently applied... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Financial management. 725.22 Section 725.22... PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.22 Financial management. (a) The agency shall account...

  16. 20 CFR 725.513 - Accountability; transfer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Accountability; transfer. 725.513 Section 725.513 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE... MINE SAFETY AND HEALTH ACT, AS AMENDED Payment of Benefits General Provisions § 725.513 Accountability...

  17. 30 CFR 725.10 - Information collection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Information collection. 725.10 Section 725.10 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INITIAL PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.10 Information collection. The information collection...

  18. 30 CFR 725.10 - Information collection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Information collection. 725.10 Section 725.10 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INITIAL PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.10 Information collection. The information collection...

  19. 30 CFR 725.10 - Information collection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Information collection. 725.10 Section 725.10 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INITIAL PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.10 Information collection. The information collection...

  20. 12 CFR 725.19 - Collateral requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Collateral requirements. 725.19 Section 725.19 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.19 Collateral requirements. (a) Each...

  1. 20 CFR 725.510 - Representative payee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Representative payee. 725.510 Section 725.510 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND... AND HEALTH ACT, AS AMENDED Payment of Benefits General Provisions § 725.510 Representative payee. (a...

  2. 18 CFR 725.5 - Council studies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Council studies. 725.5 Section 725.5 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Responsibilities § 725.5...

  3. 12 CFR 725.3 - Regular membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Regular membership. 725.3 Section 725.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.3 Regular membership. (a) A natural person credit...

  4. 40 CFR 725.50 - EPA review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...

  5. 40 CFR 725.50 - EPA review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...

  6. 40 CFR 725.50 - EPA review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...

  7. 40 CFR 725.50 - EPA review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...

  8. 40 CFR 725.50 - EPA review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false EPA review. 725.50 Section 725.50... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.50 EPA review. (a) MCANs... Document Control Officer receives a complete submission, or the date EPA determines the submission is...

  9. 42 CFR 488.725 - Unannounced surveys.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Unannounced surveys. 488.725 Section 488.725 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Home Health Agencies § 488.725 Unannounced surveys. (a) Basic rule. All HHA surveys must be unannounced...

  10. 42 CFR 488.725 - Unannounced surveys.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Unannounced surveys. 488.725 Section 488.725 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Home Health Agencies § 488.725 Unannounced surveys. (a) Basic rule. All HHA surveys must be unannounced...

  11. 20 CFR 725.412 - Operator's response.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Operator's response. 725.412 Section 725.412... AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.412 Operator's... whether the operator agrees or disagrees with the district director's designation. (2) If the responsible...

  12. 20 CFR 725.230 - Legal impediment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Legal impediment. 725.230 Section 725.230... Conditions and Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.230 Legal impediment. For purposes of this subpart, “legal impediment” means an impediment resulting from the lack of...

  13. 20 CFR 725.230 - Legal impediment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Legal impediment. 725.230 Section 725.230... Conditions and Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.230 Legal impediment. For purposes of this subpart, “legal impediment” means an impediment resulting from the lack of...

  14. 20 CFR 725.230 - Legal impediment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Legal impediment. 725.230 Section 725.230... Conditions and Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.230 Legal impediment. For purposes of this subpart, “legal impediment” means an impediment resulting from the lack of...

  15. 20 CFR 725.230 - Legal impediment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Legal impediment. 725.230 Section 725.230... Conditions and Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.230 Legal impediment. For purposes of this subpart, “legal impediment” means an impediment resulting from the lack of...

  16. 20 CFR 725.230 - Legal impediment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Legal impediment. 725.230 Section 725.230... Conditions and Duration of Entitlement: Miner's Dependents (augmented Benefits) § 725.230 Legal impediment. For purposes of this subpart, “legal impediment” means an impediment resulting from the lack of...

  17. 40 CFR 725.36 - New information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false New information. 725.36 Section 725.36... REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Administrative Procedures § 725.36 New information. (a) During the review period, if a submitter possesses, controls, or knows of new information that materially...

  18. 20 CFR 725.510 - Representative payee.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Representative payee. 725.510 Section 725.510 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH... SAFETY AND HEALTH ACT, AS AMENDED Payment of Benefits General Provisions § 725.510 Representative payee...

  19. 10 CFR 725.13 - Additional information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Additional information. 725.13 Section 725.13 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.13 Additional information. The... and before the termination of the permit, require additional information in order to enable the Chief...

  20. 30 CFR 725.22 - Financial management.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Financial management. 725.22 Section 725.22... PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.22 Financial management. (a) The agency shall account for grant funds in accordance with the requirements of Office of Management and Budget Circular A-102...

  1. 30 CFR 725.22 - Financial management.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Financial management. 725.22 Section 725.22... PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.22 Financial management. (a) The agency shall account for grant funds in accordance with the requirements of Office of Management and Budget Circular A-102...

  2. 30 CFR 725.22 - Financial management.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Financial management. 725.22 Section 725.22... PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.22 Financial management. (a) The agency shall account for grant funds in accordance with the requirements of Office of Management and Budget Circular A-102...

  3. 30 CFR 725.22 - Financial management.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Financial management. 725.22 Section 725.22... PROGRAM REGULATIONS REIMBURSEMENTS TO STATES § 725.22 Financial management. (a) The agency shall account for grant funds in accordance with the requirements of Office of Management and Budget Circular A-102...

  4. 12 CFR 725.5 - Capital stock.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Capital stock. 725.5 Section 725.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.5 Capital stock. (a) The capital stock of the Facility is divided...

  5. 12 CFR 725.4 - Agent membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Agent membership. 725.4 Section 725.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.4 Agent membership. (a) A central credit union or a group of...

  6. 20 CFR 725.422 - Legal assistance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Legal assistance. 725.422 Section 725.422... SAFETY AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.422 Legal assistance. The Secretary or his or her designee may, upon request, provide a claimant with legal assistance...

  7. 20 CFR 725.422 - Legal assistance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Legal assistance. 725.422 Section 725.422... AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.422 Legal assistance. The Secretary or his or her designee may, upon request, provide a claimant with legal assistance in...

  8. 20 CFR 725.422 - Legal assistance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Legal assistance. 725.422 Section 725.422... SAFETY AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.422 Legal assistance. The Secretary or his or her designee may, upon request, provide a claimant with legal assistance...

  9. 20 CFR 725.422 - Legal assistance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Legal assistance. 725.422 Section 725.422... SAFETY AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.422 Legal assistance. The Secretary or his or her designee may, upon request, provide a claimant with legal assistance...

  10. 20 CFR 725.422 - Legal assistance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Legal assistance. 725.422 Section 725.422... SAFETY AND HEALTH ACT, AS AMENDED Adjudication of Claims by the District Director § 725.422 Legal assistance. The Secretary or his or her designee may, upon request, provide a claimant with legal assistance...

  11. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee... agreement which includes— (1) The approved scope of the program to be covered by the grant, including...

  12. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee... agreement which includes— (1) The approved scope of the program to be covered by the grant, including...

  13. 30 CFR 725.16 - Grant agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant agreement. 725.16 Section 725.16 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.16 Grant agreement. (a) If a Director or his authorized designee... agreement which includes— (1) The approved scope of the program to be covered by the grant, including...

  14. 25 CFR 700.725 - Livestock trespass.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false Livestock trespass. 700.725 Section 700.725 Indians THE... Grazing § 700.725 Livestock trespass. The following acts are prohibited: (a) The grazing of livestock upon... Management Plan. The owner of any livestock grazing in trespass on the New Lands is liable to a civil penalty...

  15. 25 CFR 700.725 - Livestock trespass.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Livestock trespass. 700.725 Section 700.725 Indians THE... Grazing § 700.725 Livestock trespass. The following acts are prohibited: (a) The grazing of livestock upon... Management Plan. The owner of any livestock grazing in trespass on the New Lands is liable to a civil penalty...

  16. 25 CFR 700.725 - Livestock trespass.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Livestock trespass. 700.725 Section 700.725 Indians THE... Grazing § 700.725 Livestock trespass. The following acts are prohibited: (a) The grazing of livestock upon... Management Plan. The owner of any livestock grazing in trespass on the New Lands is liable to a civil penalty...

  17. 25 CFR 700.725 - Livestock trespass.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false Livestock trespass. 700.725 Section 700.725 Indians THE... Grazing § 700.725 Livestock trespass. The following acts are prohibited: (a) The grazing of livestock upon... Management Plan. The owner of any livestock grazing in trespass on the New Lands is liable to a civil penalty...

  18. 46 CFR 15.725 - Sailing short.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Sailing short. 15.725 Section 15.725 Shipping COAST... Limitations and Qualifying Factors § 15.725 Sailing short. Whenever a vessel is deprived of the service of a... vessel is sufficiently manned for the voyage. A report of sailing short must be filed in writing with the...

  19. 48 CFR 725.403 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 725.403 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade Agreements 725.403 Exceptions. FAR 25.4 establishes procedures for purchases under the Trade Agreements Act of 1979 (including GATT's Agreement on Government Procurement) and...

  20. 12 CFR 725.21 - Modification of agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Modification of agreements. 725.21 Section 725.21 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.21 Modification of agreements. The...

  1. 40 CFR 725.1000 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Scope. 725.1000 Section 725.1000 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING....1000 Scope. This subpart identifies uses of microorganisms which EPA has determined to be significant...

  2. 18 CFR 725.4 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Definitions. 725.4 Section 725.4 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Definitions. The following definitions shall apply throughout this regulation: (a) All definitions from...

  3. 28 CFR 42.725 - Assurance of compliance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Assurance of compliance. 42.725 Section 42.725 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY...; Implementation of the Age Discrimination Act of 1975 Duties of Recipients § 42.725 Assurance of compliance. Each...

  4. 6 CFR 7.25 - Identification and markings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Identification and markings. 7.25 Section 7.25 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Classified Information § 7.25 Identification and markings. (a) Classified information must be...

  5. 40 CFR 725.300 - Scope and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Scope and purpose. 725.300 Section 725.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Exemptions for Test Marketing § 725.300 Scope...

  6. 7 CFR 58.725 - Trimming and cleaning.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Trimming and cleaning. 58.725 Section 58.725 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.725 Trimming and cleaning. The natural cheese shall be cleaned free of all non-edible...

  7. 7 CFR 58.725 - Trimming and cleaning.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Trimming and cleaning. 58.725 Section 58.725 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.725 Trimming and cleaning. The natural cheese shall be cleaned free of all non-edible...

  8. PEP725 Pan European Phenological Database

    NASA Astrophysics Data System (ADS)

    Koch, E.; Lipa, W.; Ungersböck, M.; Zach-Hermann, S.

    2012-04-01

    PEP725 is a 5 years project with the main object to promote and facilitate phenological research by delivering a pan European phenological database with an open, unrestricted data access for science, research and education. PEP725 is funded by EUMETNET (the network of European meteorological services), ZAMG and the Austrian ministry for science & research bm:w_f. So far 16 European national meteorological services and 7 partners from different nati-onal phenological network operators have joined PEP725. The data access is very easy via web-access from the homepage www.pep725.eu. Ha-ving accepted the PEP725 data policy and registry the data download can be done by different criteria as for instance the selection of a specific plant or all data from one country. At present more than 300 000 new records are available in the PEP725 data-base coming from 31 European countries and from 8150 stations. For some more sta-tions (154) META data (location and data holder) are provided. Links to the network operators and data owners are also on the webpage in case you have more sophisticated questions about the data. Another objective of PEP725 is to bring together network-operators and scientists by organizing workshops. In April 2012 the second of these workshops will take place on the premises of ZAMG. Invited speakers will give presentations spanning the whole study area of phenology starting from observations to modelling. Quality checking is also a big issue. At the moment we study the literature to find ap-propriate methods.

  9. 40 CFR 35.725 - Maximum federal share.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Maximum federal share. 35.725 Section 35.725 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... Grants (pub.l. 105-276) § 35.725 Maximum federal share. The Regional Administrator may provide up to 100...

  10. 18 CFR 725.1 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Authority. 725.1 Section 725.1 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Authority. This rule is being promulgated pursuant to the Water Resources Planning Act of 1965, section 402...

  11. 18 CFR 725.0 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Purpose. 725.0 Section 725.0 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE... rule establishes the procedures to be followed by the U.S. Water Resources Council for applying...

  12. 18 CFR 725.4 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Definitions. 725.4 Section 725.4 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF..., regional, and river basin planning and reviews of compliance. (c) Council means the U.S. Water Resources...

  13. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  14. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  15. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  16. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  17. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter. ...

  18. 32 CFR 725.4 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... employed by or on behalf of the DOD or on active duty with the United States Armed Forces (determining... 32 National Defense 5 2011-07-01 2011-07-01 false Definitions. 725.4 Section 725.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL RELEASE OF OFFICIAL INFORMATION...

  19. 32 CFR 725.4 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... employed by or on behalf of the DOD or on active duty with the United States Armed Forces (determining... 32 National Defense 5 2010-07-01 2010-07-01 false Definitions. 725.4 Section 725.4 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL RELEASE OF OFFICIAL INFORMATION...

  20. 18 CFR 725.2 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Policy. 725.2 Section 725.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE..., programs, functions and resources so that the Nation may attain the widest range of beneficial uses of the...

  1. 10 CFR 725.11 - Applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., for an access permit to the Chief Health, Safety and Security Officer, HS-1/Forrestal Building, U.S...) Principal Location(s) at which Restricted Data will be used. (e) Applications should be signed by a person... 10 Energy 4 2010-01-01 2010-01-01 false Applications. 725.11 Section 725.11 Energy DEPARTMENT OF...

  2. 20 CFR 725.204 - Determination of relationship; spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; spouse. 725.204 Section 725.204 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR...) § 725.204 Determination of relationship; spouse. (a) For the purpose of augmenting benefits, an...

  3. 20 CFR 725.204 - Determination of relationship; spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of relationship; spouse. 725.204 Section 725.204 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR...) § 725.204 Determination of relationship; spouse. (a) For the purpose of augmenting benefits, an...

  4. 12 CFR 725.22 - Advances to insurance organizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Advances to insurance organizations. 725.22 Section 725.22 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.22 Advances to insurance...

  5. Count on kappa.

    PubMed

    Czodrowski, Paul

    2014-11-01

    In the 1960s, the kappa statistic was introduced for the estimation of chance agreement in inter- and intra-rater reliability studies. The kappa statistic was strongly pushed by the medical field where it could be successfully applied via analyzing diagnoses of identical patient groups. Kappa is well suited for classification tasks where ranking is not considered. The main advantage of kappa is its simplicity and the general applicability to multi-class problems which is the major difference to receiver operating characteristic area under the curve. In this manuscript, I will outline the usage of kappa for classification tasks, and I will evaluate the role and uses of kappa in specifically machine learning and cheminformatics.

  6. Pre-folding IkappaBalpha alters control of NF-kappaB signaling.

    PubMed

    Truhlar, Stephanie M E; Mathes, Erika; Cervantes, Carla F; Ghosh, Gourisankar; Komives, Elizabeth A

    2008-06-27

    Transcription complex components frequently show coupled folding and binding but the functional significance of this mode of molecular recognition is unclear. IkappaBalpha binds to and inhibits the transcriptional activity of NF-kappaB via its ankyrin repeat (AR) domain. The beta-hairpins in ARs 5-6 in IkappaBalpha are weakly-folded in the free protein, and their folding is coupled to NF-kappaB binding. Here, we show that introduction of two stabilizing mutations in IkappaBalpha AR 6 causes ARs 5-6 to fold cooperatively to a conformation similar to that in NF-kappaB-bound IkappaBalpha. Free IkappaBalpha is degraded by a proteasome-dependent but ubiquitin-independent mechanism, and this process is slower for the pre-folded mutants both in vitro and in cells. Interestingly, the pre-folded mutants bind NF-kappaB more weakly, as shown by both surface plasmon resonance and isothermal titration calorimetry in vitro and immunoprecipitation experiments from cells. One consequence of the weaker binding is that resting cells containing these mutants show incomplete inhibition of NF-kappaB activation; they have significant amounts of nuclear NF-kappaB. Additionally, the weaker binding combined with the slower rate of degradation of the free protein results in reduced levels of nuclear NF-kappaB upon stimulation. These data demonstrate clearly that the coupled folding and binding of IkappaBalpha is critical for its precise control of NF-kappaB transcriptional activity.

  7. 48 CFR 725.703 - Contractor employees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor employees. 725... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.703 Contractor employees. (a... on employees or consultants of either contractors or subcontractors providing services under an USAID...

  8. Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Sang-Myeong; Kleiboeker, Steven B.

    2005-11-10

    Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradationmore » of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.« less

  9. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  10. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  11. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  12. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  13. 36 CFR 7.25 - Hawaii Volcanoes National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Hawaii Volcanoes National Park. 7.25 Section 7.25 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.25 Hawaii Volcanoes National Park. (a...

  14. 42 CFR 456.725 - Funding of ECM system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Funding of ECM system. 456.725 Section 456.725 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Claims Management System for Outpatient Drug Claims § 456.725 Funding of ECM system. (a) For funds...

  15. 42 CFR 456.725 - Funding of ECM system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Funding of ECM system. 456.725 Section 456.725 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Claims Management System for Outpatient Drug Claims § 456.725 Funding of ECM system. (a) For funds...

  16. 40 CFR 725.95 - Public file.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Public file. All information submitted, including any health and safety study of a microorganism and... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Public file. 725.95 Section 725.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING...

  17. 40 CFR 725.95 - Public file.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Public file. All information submitted, including any health and safety study of a microorganism and... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Public file. 725.95 Section 725.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING...

  18. 40 CFR 725.95 - Public file.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Public file. All information submitted, including any health and safety study of a microorganism and... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Public file. 725.95 Section 725.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING...

  19. 40 CFR 725.95 - Public file.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public file. All information submitted, including any health and safety study of a microorganism and... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Public file. 725.95 Section 725.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT REPORTING...

  20. 9 CFR 72.5 - Area quarantined in Texas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Area quarantined in Texas. 72.5 Section 72.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF...) FEVER IN CATTLE § 72.5 Area quarantined in Texas. The area quarantined in Texas is the quarantined area...

  1. 42 CFR 456.725 - Funding of ECM system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Funding of ECM system. 456.725 Section 456.725... Claims Management System for Outpatient Drug Claims § 456.725 Funding of ECM system. (a) For funds....722, FFP is available at a matching rate of 90 percent. After fiscal year 1992, ECM subsystems are...

  2. 42 CFR 456.725 - Funding of ECM system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Funding of ECM system. 456.725 Section 456.725... Claims Management System for Outpatient Drug Claims § 456.725 Funding of ECM system. (a) For funds....722, FFP is available at a matching rate of 90 percent. After fiscal year 1992, ECM subsystems are...

  3. 20 CFR 725.458 - Depositions; interrogatories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Depositions; interrogatories. 725.458 Section... MINE SAFETY AND HEALTH ACT, AS AMENDED Hearings § 725.458 Depositions; interrogatories. The testimony of any witness or party may be taken by deposition or interrogatory according to the rules of...

  4. 20 CFR 725.458 - Depositions; interrogatories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Depositions; interrogatories. 725.458 Section... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Hearings § 725.458 Depositions; interrogatories. The testimony of any witness or party may be taken by deposition or interrogatory according to the rules of...

  5. 40 CFR 725.85 - Microorganism identity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Microorganism identity. 725.85 Section... to Information § 725.85 Microorganism identity. (a) Claims applicable to the period prior to... specific microorganism identity at the time of submission of the information. This claim will apply only to...

  6. 40 CFR 725.85 - Microorganism identity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Microorganism identity. 725.85 Section... to Information § 725.85 Microorganism identity. (a) Claims applicable to the period prior to... specific microorganism identity at the time of submission of the information. This claim will apply only to...

  7. 40 CFR 725.85 - Microorganism identity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Microorganism identity. 725.85 Section... to Information § 725.85 Microorganism identity. (a) Claims applicable to the period prior to... specific microorganism identity at the time of submission of the information. This claim will apply only to...

  8. 40 CFR 725.85 - Microorganism identity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Microorganism identity. 725.85 Section... to Information § 725.85 Microorganism identity. (a) Claims applicable to the period prior to... specific microorganism identity at the time of submission of the information. This claim will apply only to...

  9. 40 CFR 725.85 - Microorganism identity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Microorganism identity. 725.85 Section... to Information § 725.85 Microorganism identity. (a) Claims applicable to the period prior to... specific microorganism identity at the time of submission of the information. This claim will apply only to...

  10. 22 CFR 72.5 - Final report of death.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

  11. 20 CFR 725.3 - Contents of this part.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SAFETY AND HEALTH ACT, AS AMENDED General § 725.3 Contents of this part. (a) This subpart describes the... under this part. (d) Subpart D sets forth the duties and powers of the persons designated by the... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Contents of this part. 725.3 Section 725.3...

  12. 22 CFR 72.5 - Final report of death.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

  13. 22 CFR 72.5 - Final report of death.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

  14. 22 CFR 72.5 - Final report of death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

  15. 22 CFR 72.5 - Final report of death.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Final report of death. 72.5 Section 72.5... DEATHS AND ESTATES Reporting Deaths of United States Nationals § 72.5 Final report of death. (a) Preparation. Except in the case of the death of an active duty member of the United States Armed Forces, when...

  16. 46 CFR 15.725 - Sailing short.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Sailing short. 15.725 Section 15.725 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS... personnel to man the vessel, the master or person in charge may proceed on the voyage, having determined the...

  17. 18 CFR 725.5 - Council studies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Council studies. 725.5 Section 725.5 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Council studies. All studies and appraisals performed by the Council pursuant to section 102 of Pub. L. 89...

  18. 18 CFR 725.5 - Council studies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Council studies. 725.5 Section 725.5 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Council studies. All studies and appraisals performed by the Council pursuant to section 102 of Pub. L. 89...

  19. 46 CFR 15.725 - Sailing short.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Sailing short. 15.725 Section 15.725 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS... personnel to man the vessel, the master or person in charge may proceed on the voyage, having determined the...

  20. 46 CFR 15.725 - Sailing short.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Sailing short. 15.725 Section 15.725 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS... personnel to man the vessel, the master or person in charge may proceed on the voyage, having determined the...

  1. 46 CFR 15.725 - Sailing short.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Sailing short. 15.725 Section 15.725 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MANNING REQUIREMENTS... personnel to man the vessel, the master or person in charge may proceed on the voyage, having determined the...

  2. 18 CFR 725.5 - Council studies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Council studies. 725.5 Section 725.5 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Management Guidelines (43 FR 6030), E.O. 11988 and E.O. 11990 provide the basic evaluation tools for these...

  3. 18 CFR 725.5 - Council studies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Council studies. 725.5 Section 725.5 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF... Management Guidelines (43 FR 6030), E.O. 11988 and E.O. 11990 provide the basic evaluation tools for these...

  4. 40 CFR 725.422 - Physical containment and control technologies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... technologies. 725.422 Section 725.422 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Exemptions for New Microorganisms § 725.422 Physical containment and control technologies. The manufacturer must meet all of the following criteria for physical containment and control technologies for any...

  5. Kappa statistic to measure agreement beyond chance in free-response assessments.

    PubMed

    Carpentier, Marc; Combescure, Christophe; Merlini, Laura; Perneger, Thomas V

    2017-04-19

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This situation occurs frequently in imaging or other diagnostic studies. We propose here a kappa statistic that is suitable for free-response assessments. We derived the equivalent of Cohen's kappa statistic for two raters under the assumption that the number of possible findings for any given patient is very large, as well as a formula for sampling variance that is applicable to independent observations (for clustered observations, a bootstrap procedure is proposed). The proposed statistic was applied to a real-life dataset, and compared with the common practice of collapsing observations within a finite number of regions of interest. The free-response kappa is computed from the total numbers of discordant (b and c) and concordant positive (d) observations made in all patients, as 2d/(b + c + 2d). In 84 full-body magnetic resonance imaging procedures in children that were evaluated by 2 independent raters, the free-response kappa statistic was 0.820. Aggregation of results within regions of interest resulted in overestimation of agreement beyond chance. The free-response kappa provides an estimate of agreement beyond chance in situations where only positive findings are reported by raters.

  6. 20 CFR 725.207 - Determination of dependency; divorced spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; divorced spouse. 725.207 Section 725.207 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.207 Determination of dependency; divorced spouse. For the purpose of augmenting benefits...

  7. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; surviving spouse. 725.215 Section 725.215 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's...

  8. 20 CFR 725.207 - Determination of dependency; divorced spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; divorced spouse. 725.207 Section 725.207 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.207 Determination of dependency; divorced spouse. For the purpose of augmenting benefits...

  9. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; surviving spouse. 725.215 Section 725.215 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR...) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's surviving...

  10. 20 CFR 725.207 - Determination of dependency; divorced spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; divorced spouse. 725.207 Section 725.207 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.207 Determination of dependency; divorced spouse. For the purpose of augmenting benefits...

  11. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; surviving spouse. 725.215 Section 725.215 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's...

  12. 20 CFR 725.207 - Determination of dependency; divorced spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; divorced spouse. 725.207 Section 725.207 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR...) § 725.207 Determination of dependency; divorced spouse. For the purpose of augmenting benefits, an...

  13. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; surviving spouse. 725.215 Section 725.215 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's...

  14. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; surviving spouse. 725.215 Section 725.215 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's...

  15. 20 CFR 725.207 - Determination of dependency; divorced spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; divorced spouse. 725.207 Section 725.207 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... Benefits) § 725.207 Determination of dependency; divorced spouse. For the purpose of augmenting benefits...

  16. 18 CFR 725.9 - Reviews of compliance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Reviews of compliance. 725.9 Section 725.9 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION... Floodplain Management Guidelines (43 FR 6030). ...

  17. 18 CFR 725.9 - Reviews of compliance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Reviews of compliance. 725.9 Section 725.9 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION... Floodplain Management Guidelines (43 FR 6030). ...

  18. 49 CFR 236.725 - Circuit, switch shunting.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Circuit, switch shunting. 236.725 Section 236.725 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Circuit, switch shunting. A shunting circuit which is closed through contacts of a switch circuit...

  19. 49 CFR 236.725 - Circuit, switch shunting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Circuit, switch shunting. 236.725 Section 236.725 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Circuit, switch shunting. A shunting circuit which is closed through contacts of a switch circuit...

  20. 49 CFR 236.725 - Circuit, switch shunting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Circuit, switch shunting. 236.725 Section 236.725 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Circuit, switch shunting. A shunting circuit which is closed through contacts of a switch circuit...

  1. 49 CFR 236.725 - Circuit, switch shunting.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Circuit, switch shunting. 236.725 Section 236.725 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Circuit, switch shunting. A shunting circuit which is closed through contacts of a switch circuit...

  2. 49 CFR 236.725 - Circuit, switch shunting.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Circuit, switch shunting. 236.725 Section 236.725 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Circuit, switch shunting. A shunting circuit which is closed through contacts of a switch circuit...

  3. 20 CFR 725.539 - More than one reduction event.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false More than one reduction event. 725.539 Section 725.539 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... § 725.539 More than one reduction event. If a reduction for receipt of State or Federal benefits and a...

  4. 18 CFR 725.9 - Reviews of compliance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Reviews of compliance. 725.9 Section 725.9 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Responsibilities...

  5. Pharmacological characterization of the cloned kappa opioid receptor as a kappa 1b subtype.

    PubMed

    Lai, J; Ma, S W; Zhu, R H; Rothman, R B; Lentes, K U; Porreca, F

    1994-10-27

    Substantial pharmacological evidence in vitro and in vivo has suggested the existence of subtypes of the kappa opioid receptor. Quantitative radioligand binding techniques resolved the presence of two high affinity binding sites for the kappa 1 ligand [3H]U69,593 in mouse brain membranes, termed kappa 1a and kappa 1b, respectively. Whereas the kappa 1a site has high affinity for fedotozine and oxymorphindole and low affinity for bremazocine and alpha-neoendorphin, site kappa 1b has high affinity for bremazocine and alpha-neoendorphin and low affinity for fedotozine and oxymorphindole. CI-977 and U69,593 bind equally well at both sites. To determine the relationship between these kappa 1 receptor subtypes and the recently cloned mouse kappa 1 receptor (KOR), we examined [3H]U69,593 binding to the KOR in stably transfected cells (KORCHN-8). Competition of [3H]U69,593 binding to the KOR by bremazocine, alpha-neoendorphin, fedotozine and oxymorphindole resolved a single class of binding sites at which these agents had binding affinities similar to that of the kappa 1b site present in mouse brain. These results suggest that the cloned KOR corresponds to the kappa 1 site in mouse brain defined as kappa 1b.

  6. 20 CFR 725.401 - Claims development-general.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Claims development-general. 725.401 Section 725.401 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE... development—general. After a claim has been received by the district director, the district director shall...

  7. 20 CFR 725.401 - Claims development-general.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Claims development-general. 725.401 Section 725.401 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL... Claims development—general. After a claim has been received by the district director, the district...

  8. 20 CFR 725.414 - Development of evidence.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Development of evidence. 725.414 Section 725... Development of evidence. (a) Medical evidence. (1) For purposes of this section, a medical report shall.... Following the development and submission of affirmative medical evidence, the parties may submit rebuttal...

  9. 40 CFR 725.1 - Scope and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... research and development for commercial purposes. New microorganisms for which manufacturers and importers... significant new use. (b) Any manufacturer, importer, or processor required to report under section 5 of TSCA (see § 725.100 for new microorganisms and § 725.900 for significant new uses) must file a Microbial...

  10. 40 CFR 725.300 - Scope and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Exemptions for Test Marketing § 725.300 Scope... this part for test marketing activities involving microorganisms. (b) In lieu of complying with subpart D of this part, persons described in § 725.305 may submit an application for a test marketing...

  11. 40 CFR 725.17 - Consultation with EPA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...

  12. 40 CFR 725.17 - Consultation with EPA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...

  13. 40 CFR 725.17 - Consultation with EPA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...

  14. 40 CFR 725.17 - Consultation with EPA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Consultation with EPA. 725.17 Section... Applicability § 725.17 Consultation with EPA. Persons may consult with EPA, either in writing or by telephone..., ATTN: Biotechnology Notice Consultation. Persons wishing to consult with EPA by telephone should call...

  15. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; surviving divorced spouse. 725.217 Section 725.217 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner...

  16. 20 CFR 725.309 - Additional claims; effect of prior denial of benefits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (see §§ 725.202(d) (miner), 725.212 (spouse), 725.218 (child), and 725.222 (parent, brother, or sister..., child, parent, brother, or sister must be denied unless the applicable conditions of entitlement in such...

  17. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; surviving divorced spouse. 725.217 Section 725.217 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner...

  18. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; surviving divorced spouse. 725.217 Section 725.217 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner...

  19. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; surviving divorced spouse. 725.217 Section 725.217 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner...

  20. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; surviving divorced spouse. 725.217 Section 725.217 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner...

  1. 40 CFR 725.920 - Exports and imports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Exports and imports. 725.920 Section... on Significant New Uses of Microorganisms § 725.920 Exports and imports. (a) Exports. Persons who intend to export a microorganism identified in subpart M of this part, or in any proposed rule which...

  2. 40 CFR 725.25 - General administrative requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... attachments appear in the open scientific literature) must be in English. All information submitted must be... date of submission. I am including with this submission all test data in my possession or control and a description of all other data known to or reasonably ascertainable by me as required by 40 CFR 725.160 or 725...

  3. 40 CFR 725.25 - General administrative requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... attachments appear in the open scientific literature) must be in English. All information submitted must be... date of submission. I am including with this submission all test data in my possession or control and a description of all other data known to or reasonably ascertainable by me as required by 40 CFR 725.160 or 725...

  4. 40 CFR 725.25 - General administrative requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... attachments appear in the open scientific literature) must be in English. All information submitted must be... date of submission. I am including with this submission all test data in my possession or control and a description of all other data known to or reasonably ascertainable by me as required by 40 CFR 725.160 or 725...

  5. 40 CFR 725.25 - General administrative requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... attachments appear in the open scientific literature) must be in English. All information submitted must be... date of submission. I am including with this submission all test data in my possession or control and a description of all other data known to or reasonably ascertainable by me as required by 40 CFR 725.160 or 725...

  6. 40 CFR 725.25 - General administrative requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... attachments appear in the open scientific literature) must be in English. All information submitted must be... date of submission. I am including with this submission all test data in my possession or control and a description of all other data known to or reasonably ascertainable by me as required by 40 CFR 725.160 or 725...

  7. 20 CFR 725.404 - Development of evidence-general.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Development of evidence-general. 725.404 Section 725.404 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Development of evidence—general. (a) Employment history. Each claimant shall furnish the district director...

  8. 45 CFR 155.725 - Enrollment periods under SHOP.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....725 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS EXCHANGE ESTABLISHMENT STANDARDS AND OTHER RELATED STANDARDS UNDER THE AFFORDABLE CARE ACT Exchange Functions: Small Business Health Options Program (SHOP) § 155.725 Enrollment periods under SHOP. (a) General...

  9. 18 CFR 725.6 - Principles, standards and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Principles, standards and procedures. 725.6 Section 725.6 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS...

  10. 20 CFR 725.205 - Determination of dependency; spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; spouse. 725.205 Section 725.205 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; spouse. For the purposes of augmenting benefits, an individual who is the miner's...

  11. 20 CFR 725.205 - Determination of dependency; spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; spouse. 725.205 Section 725.205 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; spouse. For the purposes of augmenting benefits, an individual who is the miner's...

  12. 20 CFR 725.221 - Determination of dependency; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; child. 725.221 Section 725.221 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. For the purposes of determining whether a child was dependent upon a...

  13. 20 CFR 725.221 - Determination of dependency; child.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; child. 725.221 Section 725.221 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. For the purposes of determining whether a child was dependent upon a...

  14. 20 CFR 725.221 - Determination of dependency; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; child. 725.221 Section 725.221 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. For the purposes of determining whether a child was dependent upon a...

  15. 20 CFR 725.221 - Determination of dependency; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; child. 725.221 Section 725.221 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. For the purposes of determining whether a child was dependent upon a...

  16. 20 CFR 725.205 - Determination of dependency; spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; spouse. 725.205 Section 725.205 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; spouse. For the purposes of augmenting benefits, an individual who is the miner's...

  17. 20 CFR 725.209 - Determination of dependency; child.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; child. 725.209 Section 725.209 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL... Determination of dependency; child. (a) For purposes of augmenting the benefits of a miner or surviving spouse...

  18. 20 CFR 725.205 - Determination of dependency; spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; spouse. 725.205 Section 725.205 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; spouse. For the purposes of augmenting benefits, an individual who is the miner's...

  19. 20 CFR 725.221 - Determination of dependency; child.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; child. 725.221 Section 725.221 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL... Determination of dependency; child. For the purposes of determining whether a child was dependent upon a...

  20. 20 CFR 725.205 - Determination of dependency; spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; spouse. 725.205 Section 725.205 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL... Determination of dependency; spouse. For the purposes of augmenting benefits, an individual who is the miner's...

  1. 20 CFR 725.708 - Disputes concerning medical benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Disputes concerning medical benefits. 725.708... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.708 Disputes concerning medical benefits. (a) Whenever a dispute develops concerning medical services under...

  2. 20 CFR 725.408 - Operator's response to notification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Operator's response to notification. 725.408 Section 725.408 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL... district director, state the precise nature of its disagreement by admitting or denying each of the...

  3. 9 CFR 72.5 - Area quarantined in Texas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Area quarantined in Texas. 72.5 Section 72.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS BOVINE BABESIOSIS...

  4. 40 CFR 721.10033 - Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Zinc, [ethanedioato(2-)-. kappa. O1... Specific Chemical Substances § 721.10033 Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as zinc...

  5. 40 CFR 721.10033 - Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Zinc, [ethanedioato(2-)-. kappa. O1... Specific Chemical Substances § 721.10033 Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as zinc...

  6. 24 CFR 35.725 - Section 8 Rent adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Section 8 Rent adjustments. 35.725 Section 35.725 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance...

  7. 24 CFR 35.725 - Section 8 Rent adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Section 8 Rent adjustments. 35.725 Section 35.725 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance...

  8. 24 CFR 35.725 - Section 8 Rent adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Section 8 Rent adjustments. 35.725 Section 35.725 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance...

  9. 24 CFR 35.725 - Section 8 Rent adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Section 8 Rent adjustments. 35.725 Section 35.725 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance...

  10. 24 CFR 35.725 - Section 8 Rent adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Section 8 Rent adjustments. 35.725 Section 35.725 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance...

  11. 20 CFR 725.209 - Determination of dependency; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; child. 725.209 Section 725.209 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. (a) For purposes of augmenting the benefits of a miner or surviving spouse...

  12. 20 CFR 725.209 - Determination of dependency; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; child. 725.209 Section 725.209 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. (a) For purposes of augmenting the benefits of a miner or surviving spouse...

  13. 20 CFR 725.209 - Determination of dependency; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; child. 725.209 Section 725.209 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. (a) For purposes of augmenting the benefits of a miner or surviving spouse...

  14. 20 CFR 725.209 - Determination of dependency; child.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; child. 725.209 Section 725.209 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL... Determination of dependency; child. (a) For purposes of augmenting the benefits of a miner or surviving spouse...

  15. 20 CFR 725.705 - Arrangements for medical care.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Arrangements for medical care. 725.705... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.705 Arrangements for medical care. (a) Operator liability. If an operator has been determined liable for the...

  16. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or sister. 725.225 Section 725.225 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner...

  17. 20 CFR 725.534 - Reduction of State benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Reduction of State benefits. 725.534 Section 725.534 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL...

  18. 20 CFR 725.602 - Reimbursement of the fund.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Reimbursement of the fund. 725.602 Section 725.602 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL...

  19. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of dependency; parent, brother, or sister. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner...

  20. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of dependency; parent, brother, or sister. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner...

  1. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of dependency; parent, brother, or sister. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner...

  2. 20 CFR 725.225 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or sister. 725.225 Section 725.225 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.225 Determination of dependency; parent, brother, or sister. An individual who is the miner...

  3. 40 CFR 725.260 - Submission of health and environmental effects data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Submission of health and environmental effects data. 725.260 Section 725.260 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... for Research and Development Activities § 725.260 Submission of health and environmental effects data...

  4. 20 CFR 725.701 - Availability of medical benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Availability of medical benefits. 725.701... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.701 Availability of medical benefits. (a) A miner who is determined to be eligible for benefits under this part or...

  5. 20 CFR 725.220 - Determination of relationship; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of relationship; child. 725.220... Determination of relationship; child. For purposes of determining whether an individual may qualify for benefits as the child of a deceased miner, the provisions of § 725.208 shall be applicable. As used in this...

  6. 20 CFR 725.220 - Determination of relationship; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of relationship; child. 725.220... Determination of relationship; child. For purposes of determining whether an individual may qualify for benefits as the child of a deceased miner, the provisions of § 725.208 shall be applicable. As used in this...

  7. 20 CFR 725.220 - Determination of relationship; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of relationship; child. 725.220... Determination of relationship; child. For purposes of determining whether an individual may qualify for benefits as the child of a deceased miner, the provisions of § 725.208 shall be applicable. As used in this...

  8. 20 CFR 725.705 - Arrangements for medical care.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Arrangements for medical care. 725.705... MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.705...

  9. PEP725 Pan European Phenological Database

    NASA Astrophysics Data System (ADS)

    Koch, E.; Adler, S.; Lipa, W.; Ungersböck, M.; Zach-Hermann, S.

    2010-09-01

    Europe is in the fortunate situation that it has a long tradition in phenological networking: the history of collecting phenological data and using them in climatology has its starting point in 1751 when Carl von Linné outlined in his work Philosophia Botanica methods for compiling annual plant calendars of leaf opening, flowering, fruiting and leaf fall together with climatological observations "so as to show how areas differ". Recently in most European countries, phenological observations have been carried out routinely for more than 50 years by different governmental and non governmental organisations and following different observation guidelines, the data stored at different places in different formats. This has been really hampering pan European studies as one has to address many network operators to get access to the data before one can start to bring them in a uniform style. From 2004 to 2009 the COST-action 725 established a European wide data set of phenological observations. But the deliverables of this COST action was not only the common phenological database and common observation guidelines - COST725 helped to trigger a revival of some old networks and to establish new ones as for instance in Sweden. At the end of 2009 the COST action the database comprised about 8 million data in total from 15 European countries plus the data from the International Phenological Gardens IPG. In January 2010 PEP725 began its work as follow up project with funding from EUMETNET the network of European meteorological services and of ZAMG the Austrian national meteorological service. PEP725 not only will take over the part of maintaining, updating the COST725 database, but also to bring in phenological data from the time before 1951, developing better quality checking procedures and ensuring an open access to the database. An attractive webpage will make phenology and climate impacts on vegetation more visible in the public enabling a monitoring of vegetation development.

  10. 45 CFR 155.725 - Enrollment periods under SHOP.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Enrollment periods under SHOP. 155.725 Section 155... Functions: Small Business Health Options Program (SHOP) § 155.725 Enrollment periods under SHOP. (a) General requirements. The SHOP must— (1) Adhere to the start of the initial open enrollment period set forth in § 155...

  11. 45 CFR 155.725 - Enrollment periods under SHOP.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Enrollment periods under SHOP. 155.725 Section 155... Functions: Small Business Health Options Program (SHOP) § 155.725 Enrollment periods under SHOP. (a) General requirements. The SHOP must— (1) Adhere to the start of the initial open enrollment period set forth in § 155...

  12. 20 CFR 725.705 - Arrangements for medical care.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Arrangements for medical care. 725.705... COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.705...

  13. 20 CFR 725.456 - Introduction of documentary evidence.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Introduction of documentary evidence. 725.456 Section 725.456 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS...

  14. 20 CFR 725.456 - Introduction of documentary evidence.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Introduction of documentary evidence. 725.456 Section 725.456 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS...

  15. 20 CFR 725.456 - Introduction of documentary evidence.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Introduction of documentary evidence. 725.456 Section 725.456 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS...

  16. 20 CFR 725.456 - Introduction of documentary evidence.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Introduction of documentary evidence. 725.456 Section 725.456 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS...

  17. 20 CFR 725.456 - Introduction of documentary evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Introduction of documentary evidence. 725.456 Section 725.456 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS...

  18. 18 CFR 725.3 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.3... result in the long- or short-term adverse impacts associated with: (a) The occupancy or modification of...

  19. 18 CFR 725.7 - Regional or river basin planning.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Regional or river basin planning. 725.7 Section 725.7 Conservation of Power and Water Resources WATER RESOURCES COUNCIL... basin Level B Studies and regional water resource management plans, the responsible official...

  20. 20 CFR 725.512 - Support of legally dependent spouse, child, or parent.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., or parent. 725.512 Section 725.512 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Provisions § 725.512 Support of legally dependent spouse, child, or parent. If current maintenance needs of a... the legally dependent spouse, a legally dependent child, or a legally dependent parent of the...

  1. 12 CFR 725.18 - Creditworthiness.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.18 Creditworthiness. (a) Prior to Facility... advances for its liquidity needs. [44 FR 49437, Aug. 23, 1979, as amended at 69 FR 27829, May 17, 2004] ...

  2. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Special share accounts in federally chartered agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special...

  3. 18 CFR 725.7 - Regional or river basin planning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Regional or river basin planning. 725.7 Section 725.7 Conservation of Power and Water Resources WATER RESOURCES COUNCIL... preservation and restoration of natural and beneficial floodplain values; (4) Where avoidance of wetlands...

  4. 20 CFR 725.476 - Issuance of decision and order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Issuance of decision and order. 725.476 Section 725.476 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL... shall issue a decision and order with respect to the claim making an award to the claimant, rejecting...

  5. Resonant enhancement of Raman scattering in metamaterials with hybrid electromagnetic and plasmonic resonances

    NASA Astrophysics Data System (ADS)

    Guddala, Sriram; Narayana Rao, D.; Ramakrishna, S. Anantha

    2016-06-01

    A tri-layer metamaterial perfect absorber of light, consisting of (Al/ZnS/Al) films with the top aluminum layer patterned as an array of circular disk nanoantennas, is investigated for resonantly enhancing Raman scattering from C60 fullerene molecules deposited on the metamaterial. The metamaterial is designed to have resonant bands due to plasmonic and electromagnetic resonances at the Raman pump frequency (725 nm) as well as Stokes emission bands. The Raman scattering from C60 on the metamaterial with resonantly matched bands is measured to be enhanced by an order of magnitude more than C60 on metamaterials with off-resonant absorption bands peaking at 1090 nm. The Raman pump is significantly enhanced due to the resonance with a propagating surface plasmon band, while the highly impedance-matched electromagnetic resonance is expected to couple out the Raman emission efficiently. The nature and hybridization of the plasmonic and electromagnetic resonances to form compound resonances are investigated by numerical simulations.

  6. 20 CFR 725.507 - Guardian for minor or incompetent.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Guardian for minor or incompetent. 725.507 Section 725.507 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE...

  7. 20 CFR 725.607 - Payments in addition to compensation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... time as, but in addition to, such benefits, unless review of the order making such award is sought as... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Payments in addition to compensation. 725.607 Section 725.607 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL...

  8. 40 CFR 725.270 - EPA review of the TERA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA review of the TERA. 725.270... Development Activities § 725.270 EPA review of the TERA. General procedures for review of all submissions... to EPA review of applications submitted under this subpart: (a) Length of the review period. (1) The...

  9. KAPPA -- Kernel Application Package

    NASA Astrophysics Data System (ADS)

    Currie, Malcolm J.; Berry, David. S.

    KAPPA is an applications package comprising about 180 general-purpose commands for image processing, data visualisation, and manipulation of the standard Starlink data format---the NDF. It is intended to work in conjunction with Starlink's various specialised packages. In addition to the NDF, KAPPA can also process data in other formats by using the `on-the-fly' conversion scheme. Many commands can process data arrays of arbitrary dimension, and others work on both spectra and images. KAPPA operates from both the UNIX C-shell and the ICL command language. This document describes how to use KAPPA and its features. There is some description of techniques too, including a section on writing scripts. This document includes several tutorials and is illustrated with numerous examples. The bulk of this document comprises detailed descriptions of each command as well as classified and alphabetical summaries.

  10. Interrater reliability: the kappa statistic.

    PubMed

    McHugh, Mary L

    2012-01-01

    The kappa statistic is frequently used to test interrater reliability. The importance of rater reliability lies in the fact that it represents the extent to which the data collected in the study are correct representations of the variables measured. Measurement of the extent to which data collectors (raters) assign the same score to the same variable is called interrater reliability. While there have been a variety of methods to measure interrater reliability, traditionally it was measured as percent agreement, calculated as the number of agreement scores divided by the total number of scores. In 1960, Jacob Cohen critiqued use of percent agreement due to its inability to account for chance agreement. He introduced the Cohen's kappa, developed to account for the possibility that raters actually guess on at least some variables due to uncertainty. Like most correlation statistics, the kappa can range from -1 to +1. While the kappa is one of the most commonly used statistics to test interrater reliability, it has limitations. Judgments about what level of kappa should be acceptable for health research are questioned. Cohen's suggested interpretation may be too lenient for health related studies because it implies that a score as low as 0.41 might be acceptable. Kappa and percent agreement are compared, and levels for both kappa and percent agreement that should be demanded in healthcare studies are suggested.

  11. 40 CFR 725.170 - EPA review of the MCAN.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false EPA review of the MCAN. 725.170... Notification Requirements § 725.170 EPA review of the MCAN. General procedures for review of all submissions... to EPA review of MCANs submitted under this subpart: (a) Length of the review period. The MCAN review...

  12. 40 CFR 725.170 - EPA review of the MCAN.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA review of the MCAN. 725.170... Notification Requirements § 725.170 EPA review of the MCAN. General procedures for review of all submissions... to EPA review of MCANs submitted under this subpart: (a) Length of the review period. The MCAN review...

  13. 20 CFR 725.539 - More than one reduction event.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false More than one reduction event. 725.539... § 725.539 More than one reduction event. If a reduction for receipt of State or Federal benefits and a... first reduced (but not below zero) by the amount of the State or Federal benefits, and the remainder of...

  14. 40 CFR 725.424 - Requirements for the Tier I exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... introduced genetic material meets the criteria under § 725.421. (3) The physical containment and control... including the criteria for the recipient microorganism, the introduced genetic material, the physical... following: (i) Compliance with the introduced genetic material criteria described in § 725.421. (ii...

  15. 40 CFR 725.424 - Requirements for the Tier I exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... introduced genetic material meets the criteria under § 725.421. (3) The physical containment and control... including the criteria for the recipient microorganism, the introduced genetic material, the physical... following: (i) Compliance with the introduced genetic material criteria described in § 725.421. (ii...

  16. 40 CFR 725.424 - Requirements for the Tier I exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... introduced genetic material meets the criteria under § 725.421. (3) The physical containment and control... including the criteria for the recipient microorganism, the introduced genetic material, the physical... following: (i) Compliance with the introduced genetic material criteria described in § 725.421. (ii...

  17. 40 CFR 725.424 - Requirements for the Tier I exemption.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... introduced genetic material meets the criteria under § 725.421. (3) The physical containment and control... including the criteria for the recipient microorganism, the introduced genetic material, the physical... following: (i) Compliance with the introduced genetic material criteria described in § 725.421. (ii...

  18. 40 CFR 725.424 - Requirements for the Tier I exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... introduced genetic material meets the criteria under § 725.421. (3) The physical containment and control... including the criteria for the recipient microorganism, the introduced genetic material, the physical... following: (i) Compliance with the introduced genetic material criteria described in § 725.421. (ii...

  19. 40 CFR 725.428 - Requirements for the Tier II exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for... material meets the criteria under § 725.421. (c) Adequate physical containment and control technologies are used. The criteria listed under § 725.422 for physical containment and control technologies of...

  20. Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the I{kappa}B/NF-{kappa}B cascade by facilitating I{kappa}B kinase renaturation and blocking its further denaturation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Kyoung-Hee; Lee, Choon-Taek; Kim, Young Whan

    2005-07-01

    Heat shock (HS) treatment has been previously shown to suppress the I{kappa}B/nuclear factor-{kappa}B (NF-{kappa}B) cascade by denaturing, and thus inactivating I{kappa}B kinase (IKK). HS is characterized by the induction of a group of heat shock proteins (HSPs). However, their role in the HS-induced suppression of the I{kappa}B/NF-{kappa}B cascade is unclear. Adenovirus-mediated HSP70 overexpression was found not to suppress the TNF-{alpha}-induced activation of the I{kappa}B/NF-{kappa}B pathway, thus suggesting that HSP70 is unlikely to suppress this pathway. When TNF-{alpha}-induced activation of the I{kappa}B/NF-{kappa}B pathway was regained 24 h after HS, HSP70 was found to be highly up-regulated. Moreover, blocking HSP70 induction delayedmore » TNF-{alpha}-induced I{kappa}B{alpha} degradation and the resolubilization of IKK. In addition, HSP70 associated physically with IKK, suggesting that HSP70 is involved in the recovery process via molecular chaperone effect. Adenovirus-mediated HSP70 overexpression prior to HS blocked the I{kappa}B{alpha} stabilizing effect of HS by suppressing IKK insolubilization. Moreover, the up-regulation of endogenous HSP70 by preheating, suppressed this subsequent HS-induced IKK insolubilization, and this effect was abrogated by blocking HSP70 induction. These findings indicate that HSP70 accumulates during HS and negatively regulates the HS-induced suppression of the I{kappa}B/NF-{kappa}B cascade by facilitating the renaturation of IKK and blocking its further denaturation.« less

  1. 20 CFR 725.227 - Time of determination of relationship and dependency of survivors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Time of determination of relationship and dependency of survivors. 725.227 Section 725.227 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Benefits) § 725.227 Time of determination of relationship and dependency of survivors. The determination as...

  2. 18 CFR 725.2 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.2 Policy. It is the policy of the Council to provide leadership in floodplain management and the protection of... wetlands; (i) Involve the public throughout the floodplain management and wetlands protection...

  3. 18 CFR 725.4 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.4... definitions listed in the Glossary of the Council's Floodplain Management Guidelines for Implementing E.O... Council's Principles, Standards and Procedures (P,S,&P), provision of financial assistance for State...

  4. 18 CFR 725.2 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.2 Policy. It is the policy of the Council to provide leadership in floodplain management and the protection of... wetlands; (i) Involve the public throughout the floodplain management and wetlands protection...

  5. 18 CFR 725.2 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.2 Policy. It is the policy of the Council to provide leadership in floodplain management and the protection of... wetlands; (i) Involve the public throughout the floodplain management and wetlands protection...

  6. 20 CFR 725.227 - Time of determination of relationship and dependency of survivors.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Time of determination of relationship and dependency of survivors. 725.227 Section 725.227 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.227 Time of determination of relationship and dependency of survivors. The determination as...

  7. 20 CFR 725.227 - Time of determination of relationship and dependency of survivors.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Time of determination of relationship and dependency of survivors. 725.227 Section 725.227 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.227 Time of determination of relationship and dependency of survivors. The determination as...

  8. 20 CFR 725.227 - Time of determination of relationship and dependency of survivors.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Time of determination of relationship and dependency of survivors. 725.227 Section 725.227 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.227 Time of determination of relationship and dependency of survivors. The determination as...

  9. 20 CFR 725.227 - Time of determination of relationship and dependency of survivors.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Time of determination of relationship and dependency of survivors. 725.227 Section 725.227 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS... Benefits) § 725.227 Time of determination of relationship and dependency of survivors. The determination as...

  10. 12 CFR 725.1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.1 Scope. This part contains the regulations implementing the National Credit Union Central Liquidity Facility Act, subchapter III of the Federal Credit Union Act. The National Credit Union Administration Central Liquidity Facility is a mixed-ownership Government corporation...

  11. Inequalities between Kappa and Kappa-Like Statistics for "k x k" Tables

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2010-01-01

    The paper presents inequalities between four descriptive statistics that can be expressed in the form [P-E(P)]/[1-E(P)], where P is the observed proportion of agreement of a "kappa x kappa" table with identical categories, and E(P) is a function of the marginal probabilities. Scott's "pi" is an upper bound of Goodman and Kruskal's "lambda" and a…

  12. 21 CFR 172.725 - Gibberellic acid and its potassium salt.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Gibberellic acid and its potassium salt. 172.725... HUMAN CONSUMPTION Other Specific Usage Additives § 172.725 Gibberellic acid and its potassium salt. The food additives gibberellic acid and its potassium salt may be used in the malting of barley in...

  13. 21 CFR 172.725 - Gibberellic acid and its potassium salt.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Gibberellic acid and its potassium salt. 172.725... HUMAN CONSUMPTION Other Specific Usage Additives § 172.725 Gibberellic acid and its potassium salt. The food additives gibberellic acid and its potassium salt may be used in the malting of barley in...

  14. 18 CFR 725.1 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.1... Executive Order 11990, Protection of Wetlands, at section 6. Each of these Orders was prepared in.... 4001 et seq.), and the Flood Disaster Protection Act of 1977, as amended (87 Stat. 975). ...

  15. 18 CFR 725.1 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.1... Executive Order 11990, Protection of Wetlands, at section 6. Each of these Orders was prepared in.... 4001 et seq.), and the Flood Disaster Protection Act of 1977, as amended (87 Stat. 975). ...

  16. 18 CFR 725.1 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.1... Executive Order 11990, Protection of Wetlands, at section 6. Each of these Orders was prepared in.... 4001 et seq.), and the Flood Disaster Protection Act of 1977, as amended (87 Stat. 975). ...

  17. 18 CFR 725.1 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF WETLANDS Introduction § 725.1 Authority... Executive Order 11990, Protection of Wetlands, at section 6. Each of these Orders was prepared in.... 4001 et seq.), and the Flood Disaster Protection Act of 1977, as amended (87 Stat. 975). ...

  18. 30 CFR 7.25 - Critical characteristics.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Brattice Cloth and Ventilation Tubing § 7.25 Critical characteristics. A sample of each batch or lot of brattice cloth and ventilation tubing...

  19. 30 CFR 7.25 - Critical characteristics.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Brattice Cloth and Ventilation Tubing § 7.25 Critical characteristics. A sample of each batch or lot of brattice cloth and ventilation tubing...

  20. 30 CFR 7.25 - Critical characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Brattice Cloth and Ventilation Tubing § 7.25 Critical characteristics. A sample of each batch or lot of brattice cloth and ventilation tubing...

  1. 30 CFR 7.25 - Critical characteristics.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Brattice Cloth and Ventilation Tubing § 7.25 Critical characteristics. A sample of each batch or lot of brattice cloth and ventilation tubing...

  2. 30 CFR 7.25 - Critical characteristics.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Brattice Cloth and Ventilation Tubing § 7.25 Critical characteristics. A sample of each batch or lot of brattice cloth and ventilation tubing...

  3. 40 CFR 721.10033 - Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-. 721.10033 Section 721.10033 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1003...

  4. 40 CFR 721.10033 - Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-. 721.10033 Section 721.10033 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1003...

  5. 40 CFR 721.10033 - Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Zinc, [ethanedioato(2-)-. kappa. O1, . kappa. O2]-. 721.10033 Section 721.10033 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.1003...

  6. 40 CFR 725.239 - Use of specific microorganisms in activities conducted outside a structure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... activities conducted outside a structure. 725.239 Section 725.239 Protection of Environment ENVIRONMENTAL... MICROORGANISMS Exemptions for Research and Development Activities § 725.239 Use of specific microorganisms in activities conducted outside a structure. (a) Bradyrhizobium japonicum. To qualify for an exemption under...

  7. 40 CFR 725.239 - Use of specific microorganisms in activities conducted outside a structure.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... activities conducted outside a structure. 725.239 Section 725.239 Protection of Environment ENVIRONMENTAL... MICROORGANISMS Exemptions for Research and Development Activities § 725.239 Use of specific microorganisms in activities conducted outside a structure. (a) Bradyrhizobium japonicum. To qualify for an exemption under...

  8. Homologous kappa-neurotoxins exhibit residue-specific interactions with the alpha 3 subunit of the nicotinic acetylcholine receptor: a comparison of the structural requirements for kappa-bungarotoxin and kappa-flavitoxin binding.

    PubMed

    McLane, K E; Weaver, W R; Lei, S; Chiappinelli, V A; Conti-Tronconi, B M

    1993-07-13

    kappa-Flavotoxin (kappa-FTX), a snake neurotoxin that is a selective antagonist of certain neuronal nicotinic acetylcholine receptors (AChRs), has recently been isolated and characterized [Grant, G. A., Frazier, M. W., & Chiappinelli, V. A. (1988) Biochemistry 27, 1532-1537]. Like the related snake toxin kappa-bungarotoxin (kappa-BTX), kappa-FTX binds with high affinity to alpha 3 subtypes of neuronal AChRs, even though there are distinct sequence differences between the two toxins. To further characterize the sequence regions of the neuronal AChR alpha 3 subunit involved in formation of the binding site for this family of kappa-neurotoxins, we investigated kappa-FTX binding to overlapping synthetic peptides screening the alpha 3 subunit sequence. A sequence region forming a "prototope" for kappa-FTX was identified within residues alpha 3 (51-70), confirming the suggestions of previous studies on the binding of kappa-BTX to the alpha 3 subunit [McLane, K. E., Tang, F., & Conti-Tronconi, B. M. (1990) J. Biol. Chem. 265, 1537-1544] and alpha-bungarotoxin to the Torpedo AChR alpha subunit [Conti-Tronconi, B. M., Tang, F., Diethelm, B. M., Spencer, S. R., Reinhardt-Maelicke, S., & Maelicke, A. (1990) Biochemistry 29, 6221-6230] that this sequence region is involved in formation of a cholinergic site. Single residue substituted analogues, where each residue of the sequence alpha 3 (51-70) was sequentially replaced by a glycine, were used to identify the amino acid side chains involved in the interaction of this prototope with kappa-FTX.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. 20 CFR 725.606 - Security for the payment of benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... operator or other employer fails to provide proof of such security to the Director within 30 days of its...-compliance to the appropriate United States district court in accordance with § 725.351(c). (f) Security... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Security for the payment of benefits. 725.606...

  10. 12 CFR 725.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.2 Definitions. As used in this part: (a) Agent means an Agent... loan means an advance of funds by an Agent to a member natural person credit union to meet liquidity... or Central Liquidity Facility means the National Credit Union Administration Central Liquidity...

  11. Pan European Phenological database (PEP725): a single point of access for European data

    NASA Astrophysics Data System (ADS)

    Templ, Barbara; Koch, Elisabeth; Bolmgren, Kjell; Ungersböck, Markus; Paul, Anita; Scheifinger, Helfried; Rutishauser, This; Busto, Montserrat; Chmielewski, Frank-M.; Hájková, Lenka; Hodzić, Sabina; Kaspar, Frank; Pietragalla, Barbara; Romero-Fresneda, Ramiro; Tolvanen, Anne; Vučetič, Višnja; Zimmermann, Kirsten; Zust, Ana

    2018-06-01

    The Pan European Phenology (PEP) project is a European infrastructure to promote and facilitate phenological research, education, and environmental monitoring. The main objective is to maintain and develop a Pan European Phenological database (PEP725) with an open, unrestricted data access for science and education. PEP725 is the successor of the database developed through the COST action 725 "Establishing a European phenological data platform for climatological applications" working as a single access point for European-wide plant phenological data. So far, 32 European meteorological services and project partners from across Europe have joined and supplied data collected by volunteers from 1868 to the present for the PEP725 database. Most of the partners actively provide data on a regular basis. The database presently holds almost 12 million records, about 46 growing stages and 265 plant species (including cultivars), and can be accessed via http://www.pep725.eu/ 725.eu/" TargetType="URL"/> . Users of the PEP725 database have studied a diversity of topics ranging from climate change impact, plant physiological question, phenological modeling, and remote sensing of vegetation to ecosystem productivity.

  12. 12 CFR 725.23 - Other advances.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.23 Other advances. (a) The NCUA Board may authorize extensions of credit to members of the Facility for purposes other than liquidity needs if the NCUA Board, the Board of...

  13. The disagreeable behaviour of the kappa statistic.

    PubMed

    Flight, Laura; Julious, Steven A

    2015-01-01

    It is often of interest to measure the agreement between a number of raters when an outcome is nominal or ordinal. The kappa statistic is used as a measure of agreement. The statistic is highly sensitive to the distribution of the marginal totals and can produce unreliable results. Other statistics such as the proportion of concordance, maximum attainable kappa and prevalence and bias adjusted kappa should be considered to indicate how well the kappa statistic represents agreement in the data. Each kappa should be considered and interpreted based on the context of the data being analysed. Copyright © 2014 John Wiley & Sons, Ltd.

  14. 40 CFR 725.255 - Information to be included in the TERA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 725.255 Section 725.255 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... must have sufficient information to permit a reasoned evaluation of the health and environmental... the person believes will be useful for EPA's risk assessment. The TERA must be in writing and must...

  15. 10 CFR 725.11 - Applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.11 Applications. (a) Any person desiring access to Restricted Data pursuant to this part should submit an application (Form 378), in triplicate... access to Restricted Data for use in the performance of his duties as an employee, the application for an...

  16. 10 CFR 725.11 - Applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.11 Applications. (a) Any person desiring access to Restricted Data pursuant to this part should submit an application (Form 378), in triplicate... access to Restricted Data for use in the performance of his duties as an employee, the application for an...

  17. 10 CFR 725.11 - Applications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.11 Applications. (a) Any person desiring access to Restricted Data pursuant to this part should submit an application (Form 378), in triplicate... access to Restricted Data for use in the performance of his duties as an employee, the application for an...

  18. 10 CFR 725.11 - Applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.11 Applications. (a) Any person desiring access to Restricted Data pursuant to this part should submit an application (Form 378), in triplicate... access to Restricted Data for use in the performance of his duties as an employee, the application for an...

  19. Porcine circovirus type 2 induces the activation of nuclear factor kappa B by I{kappa}B{alpha} degradation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wei Li; Kwang, Jimmy; Wang Jin

    The transcription factor NF-{kappa}B is commonly activated upon virus infection and a key player in the induction and regulation of the host immune response. The present study demonstrated for the first time that porcine circovirus type 2 (PCV2), which is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome, can activate NF-{kappa}B in PCV2-infected PK15 cells. In PCV2-infected cells, NF-{kappa}B was activated concomitantly with viral replication, which was characterized by increased DNA binding activity, translocation of NF-{kappa}B p65 from the cytoplasm to the nucleus, as well as degradation and phosphorylation of I{kappa}B{alpha} protein. We further demonstratedmore » PCV2-induced activation of NF-{kappa}B and colocalization of p65 nuclear translocation with virus replication in cultured cells. Treatment of cells with CAPE, a selective inhibitor of NF-{kappa}B activation, reduced virus protein expression and progeny production followed by decreasing PCV2-induced apoptotic caspase activity, indicating the involvement of this transcription factor in induction of cell death. Taken together, these data suggest that NF-{kappa}B activation is important for PCV2 replication and contributes to virus-mediated changes in host cells. The results presented here provide a basis for understanding molecular mechanism of PCV2 infection.« less

  20. FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.

    PubMed

    Lee, Dong-Kee; Kang, Jae-Eun; Park, Hye-Jin; Kim, Myung-Hwa; Yim, Tae-Hee; Kim, Jung-Min; Heo, Min-Kyu; Kim, Kyu-Yeun; Kwon, Ho Jeong; Hur, Man-Wook

    2005-07-29

    The POZ domain is a highly conserved protein-protein interaction motif found in many regulatory proteins. Nuclear factor-kappaB (NF-kappaB) plays a key role in the expression of a variety of genes in response to infection, inflammation, and stressful conditions. We found that the POZ domain of FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) interacted with the Rel homology domain of the p65 subunit of NF-kappaB in both in vivo and in vitro protein-protein interaction assays. FBI-1 enhanced NF-kappaB-mediated transcription of E-selectin genes in HeLa cells upon phorbol 12-myristate 13-acetate stimulation and overcame gene repression by IkappaB alpha or IkappaB beta. In contrast, the POZ domain of FBI-1, which is a dominant-negative form of FBI-1, repressed NF-kappaB-mediated transcription, and the repression was cooperative with IkappaB alpha or IkappaB beta. In contrast, the POZ domain tagged with a nuclear localization sequence polypeptide of FBI-1 enhanced NF-kappaB-responsive gene transcription, suggesting that the molecular interaction between the POZ domain and the Rel homology domain of p65 and the nuclear localization by the nuclear localization sequence are important in the transcription enhancement mediated by FBI-1. Confocal microscopy showed that FBI-1 increased NF-kappaB movement into the nucleus and increased the stability of NF-kappaB in the nucleus, which enhanced NF-kappaB-mediated transcription of the E-selectin gene. FBI-1 also interacted with IkappaB alpha and IkappaB beta.

  1. 40 CFR 725.450 - Procedural requirements for the Tier II exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the information described in §§ 725.428 and 725.455, as well as information known to or reasonably... information that verifies compliance with the following: (1) The certifications made in the request. (2) All... microorganism, the introduced genetic material, the physical containment and control technologies. ...

  2. 18 CFR 725.8 - Report, plan and recommendation development and review.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Report, plan and recommendation development and review. 725.8 Section 725.8 Conservation of Power and Water Resources WATER RESOURCES COUNCIL IMPLEMENTATION OF EXECUTIVE ORDERS 11988, FLOODPLAIN MANAGEMENT AND 11990, PROTECTION OF...

  3. Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Benyhe, S.; Varga, E.; Hepp, J.

    1990-09-01

    The distribution and properties of frog brain kappa-opioid receptor subtypes differ not only from those of the guinea pig brain, but also from that of the rat brain. In guinea pig cerebellum the kappa 1 is the dominant receptor subtype, frog brain contains mainly the kappa 2 subtype, and the distribution of the rat brain subtypes is intermediate between the two others. In competition experiments it has been established that ethylketocyclazocine and N-cyclopropylmethyl-norazidomorphine, which are nonselective kappa-ligands, have relatively high affinities to frog brain membranes. The kappa 2 ligands (Met5)enkephalin-Arg6-Phe7 and etorphine also show high affinities to the frog brain.more » Kappa 1 binding sites measured in the presence of 5 microM/D-Ala2-Leu5/enkephalin represent 25-30% of (3H)ethylketocyclazocine binding in frog brain membranes. The kappa 2 subtype in frog brain resembles more to the mu subtype than the delta subtype of opioid receptors, but it differs from the mu subtype in displaying low affinity toward beta-endorphin and /D-Ala2-(Me)Phe4-Gly5-ol/enkephalin (DAGO). From our data it is evident that the opioid receptor subtypes are already present in the amphibian brain but the differences among them are less pronounced than in mammalian brain.« less

  4. 10 CFR 725.12 - Noneligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.12 Noneligibility. The following persons are not eligible to apply for an access permit: (a) Corporations not organized under the laws of the... of, a citizen of, or an organization organized under the laws of a country or area listed as a...

  5. 10 CFR 725.12 - Noneligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.12 Noneligibility. The following persons are not eligible to apply for an access permit: (a) Corporations not organized under the laws of the... of, a citizen of, or an organization organized under the laws of a country or area listed as a...

  6. 10 CFR 725.12 - Noneligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.12 Noneligibility. The following persons are not eligible to apply for an access permit: (a) Corporations not organized under the laws of the... of, a citizen of, or an organization organized under the laws of a country or area listed as a...

  7. 10 CFR 725.12 - Noneligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.12 Noneligibility. The following persons are not eligible to apply for an access permit: (a) Corporations not organized under the laws of the... of, a citizen of, or an organization organized under the laws of a country or area listed as a...

  8. 10 CFR 725.12 - Noneligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA Applications § 725.12 Noneligibility. The following persons are not eligible to apply for an access permit: (a) Corporations not organized under the laws of the... of, a citizen of, or an organization organized under the laws of a country or area listed as a...

  9. 20 CFR 725.311 - Communications with respect to claims; time computations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Communications with respect to claims; time computations. 725.311 Section 725.311 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF...

  10. Pan European Phenological database (PEP725): a single point of access for European data.

    PubMed

    Templ, Barbara; Koch, Elisabeth; Bolmgren, Kjell; Ungersböck, Markus; Paul, Anita; Scheifinger, Helfried; Rutishauser, This; Busto, Montserrat; Chmielewski, Frank-M; Hájková, Lenka; Hodzić, Sabina; Kaspar, Frank; Pietragalla, Barbara; Romero-Fresneda, Ramiro; Tolvanen, Anne; Vučetič, Višnja; Zimmermann, Kirsten; Zust, Ana

    2018-06-01

    The Pan European Phenology (PEP) project is a European infrastructure to promote and facilitate phenological research, education, and environmental monitoring. The main objective is to maintain and develop a Pan European Phenological database (PEP725) with an open, unrestricted data access for science and education. PEP725 is the successor of the database developed through the COST action 725 "Establishing a European phenological data platform for climatological applications" working as a single access point for European-wide plant phenological data. So far, 32 European meteorological services and project partners from across Europe have joined and supplied data collected by volunteers from 1868 to the present for the PEP725 database. Most of the partners actively provide data on a regular basis. The database presently holds almost 12 million records, about 46 growing stages and 265 plant species (including cultivars), and can be accessed via http://www.pep725.eu/ . Users of the PEP725 database have studied a diversity of topics ranging from climate change impact, plant physiological question, phenological modeling, and remote sensing of vegetation to ecosystem productivity.

  11. Pan European Phenological database (PEP725): a single point of access for European data

    NASA Astrophysics Data System (ADS)

    Templ, Barbara; Koch, Elisabeth; Bolmgren, Kjell; Ungersböck, Markus; Paul, Anita; Scheifinger, Helfried; Rutishauser, This; Busto, Montserrat; Chmielewski, Frank-M.; Hájková, Lenka; Hodzić, Sabina; Kaspar, Frank; Pietragalla, Barbara; Romero-Fresneda, Ramiro; Tolvanen, Anne; Vučetič, Višnja; Zimmermann, Kirsten; Zust, Ana

    2018-02-01

    The Pan European Phenology (PEP) project is a European infrastructure to promote and facilitate phenological research, education, and environmental monitoring. The main objective is to maintain and develop a Pan European Phenological database (PEP725) with an open, unrestricted data access for science and education. PEP725 is the successor of the database developed through the COST action 725 "Establishing a European phenological data platform for climatological applications" working as a single access point for European-wide plant phenological data. So far, 32 European meteorological services and project partners from across Europe have joined and supplied data collected by volunteers from 1868 to the present for the PEP725 database. Most of the partners actively provide data on a regular basis. The database presently holds almost 12 million records, about 46 growing stages and 265 plant species (including cultivars), and can be accessed via http://www.pep725.eu/. Users of the PEP725 database have studied a diversity of topics ranging from climate change impact, plant physiological question, phenological modeling, and remote sensing of vegetation to ecosystem productivity.

  12. The kappa statistic in rehabilitation research: an examination.

    PubMed

    Tooth, Leigh R; Ottenbacher, Kenneth J

    2004-08-01

    The number and sophistication of statistical procedures reported in medical rehabilitation research is increasing. Application of the principles and methods associated with evidence-based practice has contributed to the need for rehabilitation practitioners to understand quantitative methods in published articles. Outcomes measurement and determination of reliability are areas that have experienced rapid change during the past decade. In this study, distinctions between reliability and agreement are examined. Information is presented on analytical approaches for addressing reliability and agreement with the focus on the application of the kappa statistic. The following assumptions are discussed: (1) kappa should be used with data measured on a categorical scale, (2) the patients or objects categorized should be independent, and (3) the observers or raters must make their measurement decisions and judgments independently. Several issues related to using kappa in measurement studies are described, including use of weighted kappa, methods of reporting kappa, the effect of bias and prevalence on kappa, and sample size and power requirements for kappa. The kappa statistic is useful for assessing agreement among raters, and it is being used more frequently in rehabilitation research. Correct interpretation of the kappa statistic depends on meeting the required assumptions and accurate reporting.

  13. Mechanisms generating kappa distributions in plasmas

    NASA Astrophysics Data System (ADS)

    Livadiotis, Georgios

    2017-10-01

    Kappa distributions have become increasingly widespread across plasma physics. Publication records reveal an exponential growth of papers relevant to kappa distributions. However, the vast majority of publications refer to statistical fits and applications of these distributions in plasmas. Up to date, there is no systematic analysis on the origin of kappa distributions, that is, the mechanisms that can generate kappa distributions in plasmas. The general scheme that characterizes these mechanisms is composed of two parts: (1) the generation of local correlations among particles, and (2) the thermalization, that is, the stabilization of the particle system into stationary states described by kappa distributions or combinations thereof. Several mechanisms are known in the literature, each characterized by a specific relationship between the plasma properties. These relationships serve as conditions that need to be fulfilled for the corresponding mechanisms to be applied in the plasma. Using these relationships, we identify three mechanisms that generate kappa distributions in the solar wind plasma: (i) Debye shielding, (ii) magnetic field binding, and (iii) thermal fluctuations, each one prevailing in different scales of the solar wind plasma and magnetic field properties. The work was supported in part by the project NNX17AB74G of NASA's HGI Program.

  14. MicroRNA-22 and microRNA-140 suppress NF-{kappa}B activity by regulating the expression of NF-{kappa}B coactivators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Takata, Akemi; Otsuka, Motoyuki, E-mail: otsukamo-tky@umin.ac.jp; Kojima, Kentaro

    2011-08-12

    Highlights: {yields} miRNAs were screened for their ability to regulate NF-{kappa}B activity. {yields} miRNA-22 and miRNA-140-3p suppress NF-{kappa}B activity by regulating coactivators. {yields} miRNA-22 targets nuclear receptor coactivator 1 (NCOA1). {yields} miRNA-140-3p targets nuclear receptor-interacting protein 1 (NRIP1). -- Abstract: Nuclear factor {kappa}B (NF-{kappa}B) is a transcription factor that regulates a set of genes that are critical to many biological phenomena, including liver tumorigenesis. To identify microRNAs (miRNAs) that regulate NF-{kappa}B activity in the liver, we screened 60 miRNAs expressed in hepatocytes for their ability to modulate NF-{kappa}B activity. We found that miRNA-22 and miRNA-140-3p significantly suppressed NF-{kappa}B activity bymore » regulating the expression of nuclear receptor coactivator 1 (NCOA1) and nuclear receptor-interacting protein 1 (NRIP1), both of which are NF-{kappa}B coactivators. Our results provide new information about the roles of miRNAs in the regulation of NF-{kappa}B activity.« less

  15. 77 FR 2963 - Commission Information Collection Activities (FERC-725F); Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... submitting the information collection FERC-725F, ``Mandatory Reliability Standards for Nuclear Plant...: Title: FERC-725F Mandatory Reliability Standards for Nuclear Plant Interface Coordination OMB Control No... added a new section 215 to the FPA, which required a Commission-certified Electric Reliability...

  16. 12 CFR 725.6 - Termination of membership.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.6 Termination of membership. (a) A member of... member has failed to comply with any provision of the National Credit Union Central Liquidity Facility...

  17. 20 CFR 725.461 - Waiver of right to appear and present evidence.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Waiver of right to appear and present evidence. 725.461 Section 725.461 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF... relevant documentary evidence submitted in accordance with this part and any further written stipulations...

  18. The effects of dexamethasone on rat brain cortical nuclear factor kappa B (NF-{kappa}B) in endotoxic shock

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang Zhi; Kang Jinsong; Li Yang

    2006-08-01

    To explore the molecular mechanism of brain tissue injury induced by lipopolysaccharide (LPS), we studied the effects of endotoxic shock on rat brain cortex NF-{kappa}B and the effects of dexamethasone on these changes. Rats were randomly divided into LPS, LPS + dexamethasone, and control groups. The DNA-binding activity of NF-{kappa}B was observed using electrophoretic mobility shift assay (EMSA). Protein expression in nuclear extracts was studied using Western blots, and nuclear translocation was observed using immunohistochemistry. These indices were assayed at 1 h and 4 h after intravenous injection of LPS (4 mg.kg{sup -1}). EMSA showed significantly increased NF-{kappa}B DNA-binding activitymore » in nuclear extracts from the LPS group at both 1 h and 4 h after LPS injection, compared with the control group (P < 0.01). For the LPS group, the NF-{kappa}B DNA-binding activity was greater at 1 h than at 4 h (P < 0.05). The expression of p65 and p50 protein in the nuclear extracts was also increased, as compared with the control group. However, the expression of p65 and p50 protein from cytosolic extracts did not show any significant change. Dexamethasone down-regulated not only NF-{kappa}B DNA-binding activity but also the expression of p65 protein in the nuclear extracts. From these data, we have concluded that NF-{kappa}B activation and nuclear translocation of NF-{kappa}B play a key role in the molecular mechanism of brain tissue injury in endotoxic shock. Dexamethasone may alleviate brain injury by inhibiting NF-{kappa}B activation.« less

  19. 40 CFR 725.15 - Determining applicability when microorganism identity or use is confidential or uncertain.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... microorganism identity or use is confidential or uncertain. 725.15 Section 725.15 Protection of Environment... microorganism identity or use is confidential or uncertain. (a) Consulting EPA. Persons intending to conduct... on the Inventory, in § 725.239 or in subpart M of this part. (1) Confidential identity or use. In...

  20. 40 CFR 725.15 - Determining applicability when microorganism identity or use is confidential or uncertain.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... microorganism identity or use is confidential or uncertain. 725.15 Section 725.15 Protection of Environment... microorganism identity or use is confidential or uncertain. (a) Consulting EPA. Persons intending to conduct... on the Inventory, in § 725.239 or in subpart M of this part. (1) Confidential identity or use. In...

  1. 40 CFR 725.15 - Determining applicability when microorganism identity or use is confidential or uncertain.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... microorganism identity or use is confidential or uncertain. 725.15 Section 725.15 Protection of Environment... microorganism identity or use is confidential or uncertain. (a) Consulting EPA. Persons intending to conduct... on the Inventory, in § 725.239 or in subpart M of this part. (1) Confidential identity or use. In...

  2. 40 CFR 725.15 - Determining applicability when microorganism identity or use is confidential or uncertain.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... microorganism identity or use is confidential or uncertain. 725.15 Section 725.15 Protection of Environment... microorganism identity or use is confidential or uncertain. (a) Consulting EPA. Persons intending to conduct... on the Inventory, in § 725.239 or in subpart M of this part. (1) Confidential identity or use. In...

  3. 40 CFR 725.15 - Determining applicability when microorganism identity or use is confidential or uncertain.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... microorganism identity or use is confidential or uncertain. 725.15 Section 725.15 Protection of Environment... microorganism identity or use is confidential or uncertain. (a) Consulting EPA. Persons intending to conduct... on the Inventory, in § 725.239 or in subpart M of this part. (1) Confidential identity or use. In...

  4. The Pan European Phenological Database PEP725: Data Content and Data Quality Control Procedures

    NASA Astrophysics Data System (ADS)

    Jurkovic, Anita; Hübner, Thomas; Koch, Elisabeth; Lipa, Wolfgang; Scheifinger, Helfried; Ungersböck, Markus; Zach-Hermann, Susanne

    2014-05-01

    Phenology - the study of the timing of recurring biological events in the animal and plant world - has become an important approach for climate change impact studies in recent years. It is therefore a "conditio sine qua non" to collect, archive, digitize, control and update phenological datasets. Thus and with regard to cross-border cooperation and activities it was necessary to establish, operate and promote a pan European phenological database (PEP725). Such a database - designed and tested under cost action 725 in 2004 and further developed and maintained in the framework of the EUMETNET program PEP725 - collects data from different European governmental and nongovernmental institutions and thus offers a unique compilation of plant phenological observations. The data follows the same classification scheme - the so called BBCH coding system - that makes datasets comparable. Europe had a long tradition in the observation of phenological events: the history of collecting phenological data and their usage in climatology began in 1751. The first datasets in PEP725 date back to 1868. However, there are only a few observations available until 1950. From 1951 onwards, the phenological networks all over Europe developed rapidly: Currently, PEP725 provides about 9 million records from 23 European countries (covering approximately 50% of Europe). To supply the data in a good and uniform quality it is essential and worthwhile to establish and develop data quality control procedures. Consequently, one of the main tasks within PEP725 is the conception of a multi-stage-quality control. Currently the tests are stepwise composed: completeness -, plausibility -, time consistency -, climatological - and statistical checks. In a nutshell: The poster exemplifies the status quo of the data content of the PEP725 database and incipient stages of used and planned quality controls, respectively. For more details, we would also like to promote and refer to the PEP725 website (http

  5. Preliminary Estimation of Kappa Parameter in Croatia

    NASA Astrophysics Data System (ADS)

    Stanko, Davor; Markušić, Snježana; Ivančić, Ines; Mario, Gazdek; Gülerce, Zeynep

    2017-12-01

    Spectral parameter kappa κ is used to describe spectral amplitude decay “crash syndrome” at high frequencies. The purpose of this research is to estimate spectral parameter kappa for the first time in Croatia based on small and moderate earthquakes. Recordings of local earthquakes with magnitudes higher than 3, epicentre distances less than 150 km, and focal depths less than 30 km from seismological stations in Croatia are used. The value of kappa was estimated from the acceleration amplitude spectrum of shear waves from the slope of the high-frequency part where the spectrum starts to decay rapidly to a noise floor. Kappa models as a function of a site and distance were derived from a standard linear regression of kappa-distance dependence. Site kappa was determined from the extrapolation of the regression line to a zero distance. The preliminary results of site kappa across Croatia are promising. In this research, these results are compared with local site condition parameters for each station, e.g. shear wave velocity in the upper 30 m from geophysical measurements and with existing global shear wave velocity - site kappa values. Spatial distribution of individual kappa’s is compared with the azimuthal distribution of earthquake epicentres. These results are significant for a couple of reasons: to extend the knowledge of the attenuation of near-surface crust layers of the Dinarides and to provide additional information on the local earthquake parameters for updating seismic hazard maps of studied area. Site kappa can be used in the re-creation, and re-calibration of attenuation of peak horizontal and/or vertical acceleration in the Dinarides area since information on the local site conditions were not included in the previous studies.

  6. 77 FR 6550 - Commission Information Collection Activities (FERC-725A); Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... submitting the information collection FERC-725A, Mandatory Reliability Standards for the Bulk- Power System... Reliability Standard, in an order published in the Federal Register (76 FR 72197, 11/22/2011). FERC received...) 273-0873. SUPPLEMENTARY INFORMATION: Title: FERC-725A, Mandatory Reliability Standards for the Bulk...

  7. 30 CFR 725.17 - Grant amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS REIMBURSEMENTS TO STATES § 725.17 Grant amendments. (a) A grant amendment is a written alteration to the grant amount, grant terms or conditions, budget or period, or other administrative, technical... agency shall promptly notify the Director or his authorized designee in writing of events or proposed...

  8. 20 CFR 725.707 - Reports of physicians and supervision of medical care.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... medical care. 725.707 Section 725.707 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational...

  9. 20 CFR 725.707 - Reports of physicians and supervision of medical care.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... medical care. 725.707 Section 725.707 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and...

  10. 40 CFR 72.5 - State authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... REGULATION Acid Rain Program General Provisions § 72.5 State authority. Consistent with section 116 of the Act, the provisions of the Acid Rain Program shall not be construed in any manner to preclude any... unit or affected source under the Acid Rain Program; provided that such State requirement, if...

  11. 40 CFR 72.5 - State authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REGULATION Acid Rain Program General Provisions § 72.5 State authority. Consistent with section 116 of the Act, the provisions of the Acid Rain Program shall not be construed in any manner to preclude any... unit or affected source under the Acid Rain Program; provided that such State requirement, if...

  12. 40 CFR 72.5 - State authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATION Acid Rain Program General Provisions § 72.5 State authority. Consistent with section 116 of the Act, the provisions of the Acid Rain Program shall not be construed in any manner to preclude any... unit or affected source under the Acid Rain Program; provided that such State requirement, if...

  13. 40 CFR 72.5 - State authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REGULATION Acid Rain Program General Provisions § 72.5 State authority. Consistent with section 116 of the Act, the provisions of the Acid Rain Program shall not be construed in any manner to preclude any... unit or affected source under the Acid Rain Program; provided that such State requirement, if...

  14. 40 CFR 72.5 - State authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REGULATION Acid Rain Program General Provisions § 72.5 State authority. Consistent with section 116 of the Act, the provisions of the Acid Rain Program shall not be construed in any manner to preclude any... unit or affected source under the Acid Rain Program; provided that such State requirement, if...

  15. The Problems with the Kappa Statistic as a Metric of Interobserver Agreement on Lesion Detection Using a Third-reader Approach When Locations Are Not Prespecified.

    PubMed

    Shih, Joanna H; Greer, Matthew D; Turkbey, Baris

    2018-03-16

    To point out the problems with Cohen kappa statistic and to explore alternative metrics to determine interobserver agreement on lesion detection when locations are not prespecified. Use of kappa and two alternative methods, namely index of specific agreement (ISA) and modified kappa, for measuring interobserver agreement on the location of detected lesions are presented. These indices of agreement are illustrated by application to a retrospective multireader study in which nine readers detected and scored prostate cancer lesions in 163 consecutive patients (n = 110 cases, n = 53 controls) using the guideline of Prostate Imaging Reporting and Data System version 2 on multiparametric magnetic resonance imaging. The proposed modified kappa, which properly corrects for the amount of agreement by chance, is shown to be approximately equivalent to the ISA. In the prostate cancer data, average kappa, modified kappa, and ISA equaled 30%, 55%, and 57%, respectively, for all lesions and 20%, 87%, and 87%, respectively, for index lesions. The application of kappa could result in a substantial downward bias in reader agreement on lesion detection when locations are not prespecified. ISA is recommended for assessment of reader agreement on lesion detection. Published by Elsevier Inc.

  16. Origins and properties of kappa distributions in space plasmas

    NASA Astrophysics Data System (ADS)

    Livadiotis, George

    2016-07-01

    Classical particle systems reside at thermal equilibrium with their velocity distribution function stabilized into a Maxwell distribution. On the contrary, collisionless and correlated particle systems, such as the space and astrophysical plasmas, are characterized by a non-Maxwellian behavior, typically described by the so-called kappa distributions. Empirical kappa distributions have become increasingly widespread across space and plasma physics. However, a breakthrough in the field came with the connection of kappa distributions to the solid statistical framework of Tsallis non-extensive statistical mechanics. Understanding the statistical origin of kappa distributions was the cornerstone of further theoretical developments and applications, some of which will be presented in this talk: (i) The physical meaning of thermal parameters, e.g., temperature and kappa index; (ii) the multi-particle description of kappa distributions; (iii) the phase-space kappa distribution of a Hamiltonian with non-zero potential; (iv) the Sackur-Tetrode entropy for kappa distributions, and (v) the new quantization constant, h _{*}˜10 ^{-22} Js.

  17. Evaluating Mesorectal Lymph Nodes in Rectal Cancer Before and After Neoadjuvant Chemoradiation Using Thin-Section T2-Weighted Magnetic Resonance Imaging

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koh, Dow-Mu; Chau, Ian; Tait, Diana

    2008-06-01

    Purpose: To apply thin-section T2-weighted magnetic resoance imaging (MRI) to evaluate the number, size, distribution, and morphology of benign and malignant mesorectal lymph nodes before and after chemoradiation treatment compared with histopathologic findings. Methods and Materials: Twenty-five patients with poor-risk adenocarcinoma of the rectum treated with neoadjuvant chemoradiation were evaluated prospectively. Thin-section T2-weighted MR images obtained before and after chemoradiation treatment were independently reviewed in consensus by 2 expert radiologists to determine the tumor stage, nodal size, nodal distribution, and nodal stage. Total mesorectal excision surgery after chemoradiation allowed MR nodal stage to be compared with histopathology using {kappa} statistics.more » Nodal downstaging was compared using the Chi-square test. Results: Before chemoradiation, 152 mesorectal nodes were visible (mean, 6.2 mm; 100 benign, 52 malignant) and 4 of 52 malignant nodes were in contact with the mesorectal fascia. The nodal staging was 7/25 N0, 10/25 N1, and 7/25 N2. After chemoradiation, only 29 nodes (mean, 4.1 mm; 24 benign, 5 malignant) were visible, and none were in contact with the mesorectal fascia. Nodal downstaging was observed: 20/25 N0 and 5/25 N1 (p < 0.01, Chi-square test). There was good agreement between MRI and pathologic T-staging ({kappa} = 0.64) and N-staging ({kappa} = 0.65) after chemoradiation. Conclusions: Neoadjuvant chemoradiation treatment resulted in a decrease in size and number of malignant- and benign-appearing mesorectal nodes on MRI. Nodal downstaging and nodal regression from the mesorectal fascia were observed after treatment. MRI is a useful tool for assessing nodal response to neoadjuvant treatment.« less

  18. 40 CFR 60.725 - Test methods and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Industrial Surface Coating: Surface Coating of Plastic Parts for Business Machines § 60.725 Test methods and...

  19. 40 CFR 60.725 - Test methods and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Industrial Surface Coating: Surface Coating of Plastic Parts for Business Machines § 60.725 Test methods and...

  20. PEP725 Pan European Phenological Database

    NASA Astrophysics Data System (ADS)

    Koch, Elisabeth; Adler, Silke; Ungersböck, Markus; Zach-Hermann, Susanne

    2010-05-01

    Europe is in the fortunate situation that it has a long tradition in phenological networking: the history of collecting phenological data and using them in climatology has its starting point in 1751 when Carl von Linné outlined in his work Philosophia Botanica methods for compiling annual plant calendars of leaf opening, flowering, fruiting and leaf fall together with climatological observations "so as to show how areas differ". The Societas Meteorologicae Palatinae at Mannheim well known for its first European wide meteorological network also established a phenological network which was active from 1781 to 1792. Recently in most European countries, phenological observations have been carried out routinely for more than 50 years by different governmental and non governmental organisations and following different observation guidelines, the data stored at different places in different formats. This has been really hampering pan European studies, as one has to address many National Observations Programs (NOP) to get access to the data before one can start to bring them in a uniform style. From 2004 to 2005 the COST-action 725 was running with the main objective to establish a European reference data set of phenological observations that can be used for climatological purposes, especially climate monitoring, and detection of changes. So far the common database/reference data set of COST725 comprises 7687248 data from 7285 observation sites in 15 countries and International Phenological Gardens (IPG) spanning the timeframe from 1951 to 2000. ZAMG is hosting the database. In January 2010 PEP725 has started and will take over not only the part of maintaining, updating the database, but also to bring in phenological data from the time before 1951, developing better quality checking procedures and ensuring an open access to the database. An attractive webpage will make phenology and climate impacts on vegetation more visible in the public enabling a monitoring of

  1. Nonplanar ion acoustic waves with kappa-distributed electrons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sahu, Biswajit

    2011-06-15

    Using the standard reductive perturbation technique, nonlinear cylindrical and spherical Kadomtsev-Petviashvili equations are derived for the propagation of ion acoustic solitary waves in an unmagnetized collisionless plasma with kappa distributed electrons and warm ions. The influence of kappa-distributed electrons and the effects caused by the transverse perturbation on cylindrical and spherical ion acoustic waves (IAWs) are investigated. It is observed that increase in the kappa distributed electrons (i.e., decreasing {kappa}) decreases the amplitude of the solitary electrostatic potential structures. The numerical results are presented to understand the formation of ion acoustic solitary waves with kappa-distributed electrons in nonplanar geometry. Themore » present investigation may have relevance in the study of propagation of IAWs in space and laboratory plasmas.« less

  2. Characterizing Cometary Electrons with Kappa Distributions

    NASA Technical Reports Server (NTRS)

    Broiles, T. W.; Livadiotis, G.; Burch, J. L.; Chae, K.; Clark, G.; Cravens, T. E.; Davidson, R.; Eriksson, A.; Frahm, R. A.; Fuselier, S. A.; hide

    2016-01-01

    The Rosetta spacecraft has escorted comet 67P/Churyumov-Gerasimenko since 6 August 2014 and has offered an unprecedented opportunity to study plasma physics in the coma. We have used this opportunity to make the first characterization of cometary electrons with kappa distributions. Two three-dimensional kappa functions were fit to the observations, which we interpret as two populations of dense and warm (density 10 cubic centimeters, temperature 2 times 10 (sup 5) degrees Kelvin, invariant kappa index 10 to 1000), and rarefied and hot (density equals 0.005 cubic centimeters, temperature 5 times 10 (sup 5) degrees Kelvin, invariant kappa index equals 1 to 10) electrons. We fit the observations on 30 October 2014 when Rosetta was 20 kilometers from 67P, and 3 Astronomical Units from the Sun. We repeated the analysis on 15 August 2015 when Rosetta was 300 kilometers from the comet and 1.3 Astronomical Units from the Sun. Comparing the measurements on both days gives the first comparison of the cometary electron environment between a nearly inactive comet far from the Sun and an active comet near perihelion. We find that the warm population density increased by a factor of 3, while the temperature cooled by a factor of 2, and the invariant kappa index was unaffected. We find that the hot population density increased by a factor of 10, while the temperature and invariant kappa index were unchanged. We conclude that the hot population is likely the solar wind halo electrons in the coma. The warm population is likely of cometary origin, but its mechanism for production is not known.

  3. 37 CFR 7.25 - Sections of part 2 applicable to extension of protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Sections of part 2 applicable to extension of protection. 7.25 Section 7.25 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN FILINGS PURSUANT TO THE PROTOCOL...

  4. 40 CFR 725.400 - Scope and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms... this part, and from review under this part altogether, for manufacturing and importing of certain new... review under this part are listed in § 725.420. (c) Criteria for the introduced genetic material...

  5. Some Paradoxical Results for the Quadratically Weighted Kappa

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2012-01-01

    The quadratically weighted kappa is the most commonly used weighted kappa statistic for summarizing interrater agreement on an ordinal scale. The paper presents several properties of the quadratically weighted kappa that are paradoxical. For agreement tables with an odd number of categories "n" it is shown that if one of the raters uses the same…

  6. 20 CFR 725.708 - Disputes concerning medical benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.708... whatever action may be necessary to protect the health of a totally disabled miner. (d) Any interested...

  7. In vitro and in vivo ocular safety and eye surface permanence determination by direct and Magnetic Resonance Imaging of ion-sensitive hydrogels based on gellan gum and kappa-carrageenan.

    PubMed

    Fernández-Ferreiro, Anxo; González Barcia, Miguel; Gil-Martínez, María; Vieites-Prado, Alba; Lema, Isabel; Argibay, Barbara; Blanco Méndez, José; Lamas, Maria Jesus; Otero-Espinar, Francisco Javier

    2015-08-01

    Gellan gum, kappa-carrageenan and alginates are natural polysaccharides able to interact with different cations that can be used to elaborate ion-activated in situ gelling systems for different uses. The interaction between fluid solutions of these polysaccharides and cations presents into the tear made these biopolymers very interesting to elaborate ophthalmic drug delivery systems. The main purpose of this study is to evaluate the ability of mixtures of these polymers to obtain ion-activated ophthalmic in situ gelling systems with optimal properties for ocular use. To achieve this purpose different proportion of the biopolymers were analyzed using a mixture experimental design evaluating their transparency, mechanical properties and bioadhesion in the absence and presence of simulated tear fluid. Tear induces a rapid sol-to-gel phase transition in the mixtures forming a consistent hydrogel. The solution composed by 80% of gellan gum and 20% kappa-carrageenan showed the best mechanical and mucoadhesive properties. This mixture was evaluated for rheological behavior, microstructure, cytotoxicity, acute corneal irritancy, ex-vivo and in vivo ocular toxicity and in vivo corneal contact time using Magnetic Resonance Images (MRI) techniques. Result indicates that the system is safe at ophthalmic level and produces an extensive ocular permanence higher than 6h. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Generation of Kappa Distributions in Solar Wind at 1 au

    NASA Astrophysics Data System (ADS)

    Livadiotis, G.; Desai, M. I.; Wilson, L. B., III

    2018-02-01

    We examine the generation of kappa distributions in the solar wind plasma near 1 au. Several mechanisms are mentioned in the literature, each characterized by a specific relationship between the solar wind plasma features, the interplanetary magnetic field (IMF), and the kappa index—the parameter that governs the kappa distributions. This relationship serves as a signature condition that helps the identification of the mechanism in the plasma. In general, a mechanism that generates kappa distributions involves a single or a series of stochastic or physical processes that induces local correlations among particles. We identify three fundamental solar wind plasma conditions that can generate kappa distributions, noted as (i) Debye shielding, (ii) frozen IMF, and (iii) temperature fluctuations, each one prevailing in different scales of solar wind plasma and magnetic field properties. Moreover, our findings show that the kappa distributions, and thus, their generating mechanisms, vary significantly with solar wind features: (i) the kappa index has different dependence on the solar wind speed for slow and fast modes, i.e., slow wind is characterized by a quasi-constant kappa index, κ ≈ 4.3 ± 0.7, while fast wind exhibits kappa indices that increase with bulk speed; (ii) the dispersion of magnetosonic waves is more effective for lower kappa indices (i.e., further from thermal equilibrium); and (iii) the kappa and polytropic indices are positively correlated, as it was anticipated by the theory.

  9. Obliquely Propagating Waves in Bi-Kappa Plasmas

    NASA Astrophysics Data System (ADS)

    Gaelzer, R.; Ziebell, L. F.; Meneses, A. R.

    2016-12-01

    The effects of kappa velocity distribution functions (VDFs) have been the subjectof intense research. Such functions have beenfound to provide a better fitting to the VDFs measured by spacecraftin the solar wind. An anisotropic VDF contains free energy that can excite wavesin the plasma. The induced turbulence also determines the observed shape of the VDF.The general treatment for waves excited by (bi-)Maxwellian plasmas is well-established.However, for kappa distributions (isotropic or anisotropic), the majority of the studieswere restricted to the limiting cases of purely parallel or perpendicular propagation.Contributions to the general case of obliquely-propagating waves have been scarcely reported.The absence of a general treatment prevents a complete analysis of the wave-particle interactionin kappa plasmas, since some instabilities can operate both in the parallel and oblique directions.A series of papers published by the authors begin to remedy this situation. In a first work [1],we have obtained the dielectric tensor and dispersion relations for quasi-perpendicular dispersive Alfvén waves resulting from a kappa VDF. This approach was later generalized by [2],where the formalism was extended to the general case of electrostatic/electromagnetic waves propagatingin an isotropic kappa plasma in any frequency range and for arbitrary angles.In the present work [3], we generalize even further the formalism by the derivation of thegeneral dielectric tensor of an anisotropic bi-kappa plasma. We present the state-of-the-art of theformalism and show how it enables a systematic study of waves and instabilities propagating inarbitrary directions and frequencies in a bi-kappa plasma.[1] R. Gaelzer, L. F. Ziebell, J. Geophys. Res. 119, 9334 (2014), doi: 10.1002/2014JA020667.[2] R. Gaelzer, L. F. Ziebell, Phys. Plasmas 23, 022110 (2016), doi: 10.1063/1.4941260.[3] R. Gaelzer et al., Phys. Plasmas 23, 062108 (2016), doi: 10.1063/1.4953430.

  10. 12 CFR 725.20 - Repayment, security and credit reporting agreements; other terms and conditions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Repayment, security and credit reporting agreements; other terms and conditions. 725.20 Section 725.20 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY...

  11. Resampling probability values for weighted kappa with multiple raters.

    PubMed

    Mielke, Paul W; Berry, Kenneth J; Johnston, Janis E

    2008-04-01

    A new procedure to compute weighted kappa with multiple raters is described. A resampling procedure to compute approximate probability values for weighted kappa with multiple raters is presented. Applications of weighted kappa are illustrated with an example analysis of classifications by three independent raters.

  12. Kappa-Electrons Downstream of the Solar Wind Termination Shock

    NASA Astrophysics Data System (ADS)

    Fahr, H. J.

    2017-12-01

    A theoretical description of the solar wind electron distribution function downstream of the termination shock under the influence of the shock-induced injection of overshooting KeV-energetic electrons will be presented. A kinetic phasespace transport equation in the bulk frame of the heliosheath plasma flow is developed for the solar wind electrons, taking into account shock-induced electron injection, convective changes, magnetic cooling processes and whistler wave-induced energy diffusion. Assuming that the local electron distribution under the prevailing Non-LTE conditions can be represented by a local kappa function with a local kappa parameter that varies with the streamline coordinates, we determine the parameters of the resulting, initial kappa distribution for the downstream electrons. From this initial function spectral electron fluxes can be derived and can be compared with those measured by the VOYAGER-1 spacecraft in the range between 40 to 70 KeV. It can then be shown that with kappa values around kappa = 6 one can in fact fit these data very satisfactorily. In addition it is shown that for isentropic electron flows kappa-distributed electrons have to undergo simultaneous changes of both parameters, i.e. kappa and theta, of the electron kappa function. It is also shown then that under the influence of energy sinks and sources the electron flux becomes non-isentropic with electron entropies changing along the streamline.

  13. 20 CFR 725.414 - Development of evidence.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... liable operators under § 725.410(a)(3), the district director shall be entitled to exercise the rights of... to develop medical evidence to determine whether the medical bill is compensable under the standard... related disease, or medical treatment for a respiratory or pulmonary or related disease, may be received...

  14. 20 CFR 725.414 - Development of evidence.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... liable operators under § 725.410(a)(3), the district director shall be entitled to exercise the rights of... to develop medical evidence to determine whether the medical bill is compensable under the standard... related disease, or medical treatment for a respiratory or pulmonary or related disease, may be received...

  15. 20 CFR 725.414 - Development of evidence.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... liable operators under § 725.410(a)(3), the district director shall be entitled to exercise the rights of... to develop medical evidence to determine whether the medical bill is compensable under the standard... related disease, or medical treatment for a respiratory or pulmonary or related disease, may be received...

  16. 20 CFR 725.493 - Employment relationship defined.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Employment relationship defined. 725.493... relationship defined. (a)(1) In determining the identity of a responsible operator under this part, the terms “employ” and “employment” shall be construed as broadly as possible, and shall include any relationship...

  17. 20 CFR 725.493 - Employment relationship defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Employment relationship defined. 725.493... relationship defined. (a)(1) In determining the identity of a responsible operator under this part, the terms “employ” and “employment” shall be construed as broadly as possible, and shall include any relationship...

  18. 20 CFR 725.366 - Fees for representatives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Adjudication Officers; Parties and Representatives § 725.366... person performing such work, and the customary billing rate for each such person. The application shall...

  19. PEP725: real time monitoring of phenological events in Austria, Germany, Sweden and Switzerland

    NASA Astrophysics Data System (ADS)

    Ungersboeck, Markus; Bolmgren, Kjell; Huebner, Thomas; Kaspar, Frank; Langvall, Ola; Paul, Anita; Pietragalla, Barbara; Scheifinger, Helfried; Koch, Elisabeth

    2017-04-01

    The main objective of PEP725 (Pan European Phenological database; http://www.pep725.eu/) is to promote and facilitate phenological research by delivering a pan European phenological database with an open, unrestricted data access for science, research and education. The first datasets in PEP725 date back to 1868; however, there are only a few observations available until 1950. From 1951 onwards, the phenological networks all over Europe developed rapidly. So far more than 11 923 489 of observations of 121 different plants are now available in the PEP725 database. Approximately 40 % of all data are flowering records, 10 % are fruit ripeness observations and also 10 % are leaf unfolding observations. The PEP725 database is updated annually. But since recently Deutscher Wetterdienst and MeteoSwiss offer their observers to upload their observations via web in real time mode, ZAMG introduced this web-based feature already in 2007 (phenowatch.at) and the observers of SWE-NPN (the Swedish National Phenology Network) can submit their observations through the web application naturenskalender.se since the start in 2008. Since spring 2016 one you can find a real time animated monitoring tool showing how the "green wave" in spring is moving from 46° northern latitude up to the Arctic Circle and the "brown wave" in autumn in the opposite direction. In 2015 the "green wave" speeds up from app. 4.4 days/degree latitude for hazel flowering to 2.9 days/ degree latitude for willow flowering and 2.25 days/degree latitude for birch leaf unfolding. There are other European countries as for instance Italy, The Netherlands, UK that have been doing visualizations of ground phenology in real time for some years, but these efforts always end at the national borders. PEP725 is funded by ZAMG, the Austrian ministry of science, research and economy and EUMETNET, the network of European meteorological services. So far 21 European meteorological services and 7 partners from different

  20. Nonequilibrium approach regarding metals from a linearised kappa distribution

    NASA Astrophysics Data System (ADS)

    Domenech-Garret, J. L.

    2017-10-01

    The widely used kappa distribution functions develop high-energy tails through an adjustable kappa parameter. The aim of this work is to show that such a parameter can itself be regarded as a function, which entangles information about the sources of disequilibrium. We first derive and analyse an expanded Fermi-Dirac kappa distribution. Later, we use this expanded form to obtain an explicit analytical expression for the kappa parameter of a heated metal on which an external electric field is applied. We show that such a kappa index causes departures from equilibrium depending on the physical magnitudes. Finally, we study the role of temperature and electric field on such a parameter, which characterises the electron population of a metal out of equilibrium.

  1. 40 CFR 725.455 - Information to be included in the Tier II exemption request.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... identification. (2) Type of genetic modification and the function of the introduced genetic material. (3) Site of insertion. (4) Certification of compliance with the introduced genetic material criteria described in § 725... permits. (f) The certification statement required in § 725.25(b). Certification of submission of test data...

  2. Transverse Mode Formation in Positive Branch Unstable Resonators.

    DTIC Science & Technology

    1983-08-01

    UNSTABLE RESONATORS S. PERFORMING ORG11. REPORT NURSER 7. AUTNOR(q) S. CONTRACT OR GRANT NUMS1ER111) R. William Jones S. PERFORMING ORGANIZATION NAME AND...EIAO-IWETA .3WSTPOSCOS(TIOUTA) SOIC 725 710 J 24S6JWINT94p DATA 4 1* 1) t) ?AJI1*Mot MT1MPUMI’dSTPZ wwub**vSTP%-wI ’wSTPj 733 IU(ISIGN)7319?43,?40

  3. Measurement of Angle Kappa Using Ultrasound Biomicroscopy and Corneal Topography

    PubMed Central

    Yeo, Joon Hyung; Moon, Nam Ju

    2017-01-01

    Purpose To introduce a new convenient and accurate method to measure the angle kappa using ultrasound biomicroscopy (UBM) and corneal topography. Methods Data from 42 eyes (13 males and 29 females) were analyzed in this study. The angle kappa was measured using Orbscan II and calculated with UBM and corneal topography. The angle kappa of the dominant eye was compared with measurements by Orbscan II. Results The mean patient age was 36.4 ± 13.8 years. The average angle kappa measured by Orbscan II was 3.98° ± 1.12°, while the average angle kappa calculated with UBM and corneal topography was 3.19° ± 1.15°. The difference in angle kappa measured by the two methods was statistically significant (p < 0.001). The two methods showed good reliability (intraclass correlation coefficient, 0.671; p < 0.001). Bland-Altman plots were used to demonstrate the agreement between the two methods. Conclusions We designed a new method using UBM and corneal topography to calculate the angle kappa. This method is convenient to use and allows for measurement of the angle kappa without an expensive device. PMID:28471103

  4. Measurement of Angle Kappa Using Ultrasound Biomicroscopy and Corneal Topography.

    PubMed

    Yeo, Joon Hyung; Moon, Nam Ju; Lee, Jeong Kyu

    2017-06-01

    To introduce a new convenient and accurate method to measure the angle kappa using ultrasound biomicroscopy (UBM) and corneal topography. Data from 42 eyes (13 males and 29 females) were analyzed in this study. The angle kappa was measured using Orbscan II and calculated with UBM and corneal topography. The angle kappa of the dominant eye was compared with measurements by Orbscan II. The mean patient age was 36.4 ± 13.8 years. The average angle kappa measured by Orbscan II was 3.98° ± 1.12°, while the average angle kappa calculated with UBM and corneal topography was 3.19° ± 1.15°. The difference in angle kappa measured by the two methods was statistically significant (p < 0.001). The two methods showed good reliability (intraclass correlation coefficient, 0.671; p < 0.001). Bland-Altman plots were used to demonstrate the agreement between the two methods. We designed a new method using UBM and corneal topography to calculate the angle kappa. This method is convenient to use and allows for measurement of the angle kappa without an expensive device. © 2017 The Korean Ophthalmological Society

  5. 20 CFR 725.547 - Applicability of overpayment and underpayment provisions to operator or carrier.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Applicability of overpayment and underpayment provisions to operator or carrier. 725.547 Section 725.547 Employees' Benefits EMPLOYMENT STANDARDS... BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Payment of Benefits...

  6. NF-kappaB modulators from Valeriana officinalis.

    PubMed

    Jacobo-Herrera, Nadia J; Vartiainen, Nina; Bremner, Paul; Gibbons, Simon; Koistinaho, Jari; Heinrich, Michael

    2006-10-01

    Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy. This study reports that the EtOAc extract of the underground parts of V. officinalis showed inhibitory activity against NF-kappaB at 100 microg/mL in the IL-6/Luc assay on HeLa cells and provided protection against excitotoxicity in primary brain cell cultures at micromolar concentrations. Bioassay-guided fractionation of the EtOAc extract led to the isolation of three known sesquiterpenes: acetylvalerenolic acid (1), valerenal (2) and valerenic acid (3), 1 and 3 were active as inhibitors of NF-kappaB at a concentration of 100 microg/mL. Acetylvalerenolic acid (1) reduced NF-kappaB activity to 4%, whereas valerenic acid (3) reduced NF-kappaB activity to 25%. Copyright 2006 John Wiley & Sons, Ltd.

  7. 14 CFR 29.725 - Limit drop test.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Landing Gear § 29.725 Limit drop test. The... energy absorbing devices or by the use of an effective mass. (c) Each landing gear unit must be tested in... to be absorbed by it. (d) When an effective mass is used in showing compliance with paragraph (b) of...

  8. NF-kappaB mediates FGF signal regulation of msx-1 expression.

    PubMed

    Bushdid, P B; Chen, C L; Brantley, D M; Yull, F; Raghow, R; Kerr, L D; Barnett, J V

    2001-09-01

    The nuclear factor-kappaB (NF-kappaB) family of transcription factors is involved in proliferation, differentiation, and apoptosis in a stage- and cell-dependent manner. Recent evidence has shown that NF-kappaB activity is necessary for both chicken and mouse limb development. We report here that the NF-kappaB family member c-rel and the homeodomain gene msx-1 have partially overlapping expression patterns in the developing chick limb. In addition, inhibition of NF-kappaB activity resulted in a decrease in msx-1 mRNA expression. Sequence analysis of the msx-1 promoter revealed three potential kappaB-binding sites similar to the interferon-gamma (IFN-gamma) kappaB-binding site. These sites bound to c-Rel, as shown by electrophoretic mobility shift assay (EMSA). Furthermore, inhibition of NF-kappaB activity significantly reduced transactivation of the msx-1 promoter in response to FGF-2/-4, known stimulators of msx-1 expression. These results suggest that NF-kappaB mediates the FGF-2/-4 signal regulation of msx-1 gene expression. Copyright 2001 Academic Press.

  9. Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of I{kappa}B{alpha} and nuclear accumulation of NF-{kappa}B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maier, Jana V., E-mail: Jana.maier@kit.edu; Volz, Yvonne; Berger, Caroline

    2010-10-22

    Research highlights: {yields}Bag-1 depletion only marginally affects the action of the glucocorticoid receptor but strongly regulates the activity of NF-{kappa}B. {yields}Bag-1 depletion attenuates phosphorylation and degradation of I{kappa}B{alpha} and nuclear accumulation of NF-{kappa}B p65 and p50. {yields}Bag-1 interacts with I{kappa}B{alpha} and partially restores I{kappa}B{alpha} and NF-{kappa}B activation in Bag-1 depleted cells. -- Abstract: Bag-1 consists in humans of four isoforms generated from the same RNA by alternative translation. Overexpression of single Bag-1 isoforms has identified Bag-1 as a negative regulator of action of many proteins including the glucocorticoid receptor (GR). Here we have analysed the ability of Bag-1 to regulatemore » the transrepression function of the GR. Silencing Bag-1 expression only marginally affects the transrepression action of the GR but decreased the action of the transcription factor NF-{kappa}B. Furthermore phosphorylation and degradation of the inhibitor protein I{kappa}B{alpha} and nuclear accumulation of p65 and p50 NF-{kappa}B proteins in response to phorbol ester was attenuated following Bag-1 depletion in HeLa cells. Reconstitution of Bag-1 in depleted cells partially restored I{kappa}B{alpha} and NF-{kappa}B activation. Knock-down of Bag-1 expression also did not significantly alter GR-mediated transactivation but affected the basal transcription of some of the target genes. Thus Bag-1 proteins function as regulators of the action of selective transcription factors.« less

  10. 20 CFR 725.520 - Computation of benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Payment of Benefits Benefit Rates § 725.520 Computation of benefits. (a) Basic rate. The amount of benefits payable to a beneficiary for a month is determined, in the first instance, by computing the “basic rate.” The basic rate is equal to 371/2 percent of the monthly...

  11. 20 CFR 725.520 - Computation of benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MINE SAFETY AND HEALTH ACT, AS AMENDED Payment of Benefits Benefit Rates § 725.520 Computation of benefits. (a) Basic rate. The amount of benefits payable to a beneficiary for a month is determined, in the first instance, by computing the “basic rate.” The basic rate is equal to 371/2 percent of the monthly...

  12. 48 CFR 725.705 - Local procurement-contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement-contract... DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.705 Local procurement—contract clause. Local procurement may be undertaken in accordance with the provisions of 22 CFR...

  13. 48 CFR 725.705 - Local procurement-contract clause.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Local procurement-contract... DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.705 Local procurement—contract clause. Local procurement may be undertaken in accordance with the provisions of 22 CFR...

  14. 2 CFR 180.725 - How much time do I have to contest a suspension?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How much time do I have to contest a suspension? 180.725 Section 180.725 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE... sends it if the letter is undeliverable; (2) When sent, if the agency sends the notice by facsimile or...

  15. 20 CFR 725.603 - Payments by the fund on behalf of an operator; liens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; liens. 725.603 Section 725.603 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF....603 Payments by the fund on behalf of an operator; liens. (a) If an amount is paid out of the fund to..., the amount of such liability, there shall be a lien in favor of the United States upon all property...

  16. NF-{kappa}B regulates Lef1 gene expression in chondrocytes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yun, Kangsun; Choi, Yoo Duk; Nam, Jong Hee

    The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the sitemore » was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.« less

  17. IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang

    2010-12-20

    Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absencemore » of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.« less

  18. [Effects of different nuclear factor kappaB dimers on the survival of immortalized neural progenitor cells].

    PubMed

    Gui, Ling-Li; Zhang, Chuan-Han; Liu, Zhi-Heng; Chen, Zhao-Jun; Zhu, Chang

    2008-04-01

    To investigate the effects of different nuclear factor (NF)-KB dimers on the survival of immortalized neural progenitor cells (INPCs). The control vector RC/CMV, containing the promoter of cytomegalovirus (CMV), and the expression vectors, RcCMV-p50 and RcCMV-p65, containing the coding regions of NF-KB subunits p50 and p65 genes, were transfected into the INPCs by liposome respectively. Stably transfected clones were screened out following G418 selection. Subsequently, the plasmid RcCMV-p50 was transiently transfected into the INPCs which had been stably transfected with the plasmid RcCMV-p65. The expression of p50 or p65 gene was detected in each cell strain by Western blotting. And the NF-KB DNA binding activity in the cell nuclear extracts was measured by electrophoresis mobility shift assay (EMSA). The expression of IkappaBalpha in the cytoplasm was detected by Western blotting. After oxygen and glucose deprivation for 13 h, the cell survival rate was measured by MTT assay. After gene transfection, five different cell strains were obtained: INPC, INPC/CMV, INPC/p50, INPC/p65, and INPC/p50p65. p50 or p65 gene was translated correctly and efficiently in the cell strains which had been transfected with the corresponding plasmids. EMSA showed that the INPC/p50, INPC/p65, and INPC/p50p65 cells all gave rise to NF-kappaB specific bands, which were composed of p50 homodimer, p65 homodimer, and p50 p65 heterodimer and p50 homodimer respectively. The expression of IkappaBbeta was increased significantly in the cytoplasm of the INPC/p65 and INPC/p50p65 cells. Games-Howell test showed that after oxygen and glucose deprivation for 13 h, the survival rates of the NPC/p65 and INPC/p50p65 cells were (6.0 +/- 1.0)% and (4.6 +/- 0.6)% respectively, both significantly lower than those of the INPC, INPC/CMV, and INPC/p50 cells [(72.5 +/- 6.2)%, (70.1 +/- 4.3)%, and (70.4 +/- 7.3)% respectively, all P < 0.05]. Overexpression of p50 gene and p65 gene directly enhance the DNA

  19. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex.

    PubMed

    Bergqvist, Simon; Croy, Carrie H; Kjaergaard, Magnus; Huxford, Tom; Ghosh, Gourisankar; Komives, Elizabeth A

    2006-07-07

    IkappaBalpha is an ankyrin repeat protein that inhibits NF-kappaB transcriptional activity by sequestering NF-kappaB outside of the nucleus in resting cells. We have characterized the binding thermodynamics and kinetics of the IkappaBalpha ankyrin repeat domain to NF-kappaB(p50/p65) using surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). SPR data showed that the IkappaBalpha and NF-kappaB associate rapidly but dissociate very slowly, leading to an extremely stable complex with a K(D,obs) of approximately 40 pM at 37 degrees C. As reported previously, the amino-terminal DNA-binding domain of p65 contributes little to the overall binding affinity. Conversely, helix four of p65, which forms part of the nuclear localization sequence, was essential for high-affinity binding. This was surprising, given the small size of the binding interface formed by this part of p65. The NF-kappaB(p50/p65) heterodimer and p65 homodimer bound IkappaBalpha with almost indistinguishable thermodynamics, except that the NF-kappaB p65 homodimer was characterized by a more favorable DeltaH(obs) relative to the NF-kappaB(p50/p65) heterodimer. Both interactions were characterized by a large negative heat capacity change (DeltaC(P,obs)), approximately half of which was contributed by the p65 helix four that was necessary for tight binding. This could not be accounted for readily by the small loss of buried non-polar surface area and we hypothesize that the observed effect is due to additional folding of some regions of the complex.

  20. 18 CFR 725.6 - Principles, standards and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Principles, standards... Responsibilities § 725.6 Principles, standards and procedures. The Principles, Standards and Procedures established... Orders. These Principles, Standards and Procedures are found in 18 CFR parts 710 through 717. ...

  1. 42 CFR 456.725 - Funding of ECM system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Claims Management System for Outpatient Drug Claims § 456.725 Funding of ECM system. (a) For funds..., and implementation of an on-line, real-time claims management system (that is, the most cost-effective... process that is integrated into a single comprehensive utilization and information reporting system. ...

  2. Kappa angles in different positions in patients with myopia during LASIK

    PubMed Central

    Qi, Hui; Jiang, Jing-Jing; Jiang, Yan-Ming; Wang, Li-Qiang; Huang, Yi-Fei

    2016-01-01

    AIM To investigate the difference in kappa angle between sitting and supine positions during laser-assisted in situ keratomileusis (LASIK). METHODS A retrospective study was performed on 395 eyes from 215 patients with myopia that received LASIK. Low, moderate, and high myopia groups were assigned according to diopters. The horizontal and vertical components of kappa angle in sitting position were measured before the operation, and in supine position during the operation. The data from the two positions were compared and the relationship between kappa angle and diopters were analyzed. RESULTS Two hundred and twenty-three eyes (56.5%) in sitting position and 343 eyes (86.8%) in supine position had positive kappa angles. There were no significant differences in horizontal and vertical components of kappa angle in the sitting position or horizontal components of kappa angle in the supine position between the three groups (P>0.05). A significant difference in the vertical components of kappa angle in the supine position was seen in the three groups (P<0.01). Differences in both horizontal and vertical components of kappa angles were significant between the sitting and supine positions. Positive correlations in both horizontal and vertical components of kappa angles (P<0.05) were found and vertical components of kappa angle in sitting and supine positions were negatively correlated with the degree of myopia (sitting position: r=-0.109; supine position: r=-0.172; P<0.05). CONCLUSION There is a correlation in horizontal and vertical components of kappa angle in sitting and supine positions. Positive correlations in both horizontal and vertical components of kappa angle in sitting and supine positions till the end of the results. This result still needs further observation. Clinicians should take into account different postures when excimer laser surgery needs to be performed. PMID:27162734

  3. Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B.

    PubMed

    Bourke, E; Moynagh, P N

    1999-08-15

    Glucocorticoids are potent antiinflammatory drugs. They inhibit the expression of proinflammatory cytokines and adhesion molecules. It has recently been proposed that the underlying basis to such inhibition is the induction of the protein I kappa B, which inhibits the transcription factor NF-kappa B. The latter is a key activator of the genes encoding cytokines and adhesion molecules. The present study shows that the synthetic glucocorticoid, dexamethasone, inhibits the induction of the proinflammatory cytokine IL-8 and the adhesion molecules VCAM-1 and ICAM-1 in human 1321N1 astrocytoma and SK.N.SH neuroblastoma cells. However, dexamethasone failed to induce I kappa B or inhibit activation of NF-kappa B by IL-1 in the two cell types. EMSA confirmed the identity of the activated NF-kappa B by demonstrating that an oligonucleotide, containing the wild-type NF-kappa B-binding motif, inhibited formation of the NF-kappa B-DNA complexes whereas a mutated form of the NF-kappa B-binding motif was ineffective. In addition, supershift analysis showed that the protein subunits p50 and p65 were prevalent components in the activated NF-kappa B complexes. The lack of effect of dexamethasone on the capacity of IL-1 to activate NF-kappa B correlated with its inability to induce I kappa B and the ability of IL-1 to cause degradation of I kappa B, even in the presence of dexamethasone. The results presented in this paper strongly suggest that glucocorticoids may exert antiinflammatory effects in cells of neural origin by a mechanism(s) independent of NF-kappa B.

  4. 20 CFR 725.406 - Medical examinations and tests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Medical examinations and tests. 725.406... Medical examinations and tests. (a) The Act requires the Department to provide each miner who applies for... list of medical facilities and physicians in the state of the miner's residence and states contiguous...

  5. Ion-cyclotron instability in plasmas described by product-bi-kappa distributions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Santos, M. S. dos; Ziebell, L. F., E-mail: luiz.ziebell@ufrgs.br; Gaelzer, R., E-mail: rudi.gaelzer@ufrgs.br

    The dispersion relation for parallel propagating waves in the ion-cyclotron branch is investigated numerically by considering that the velocity distribution of the ion population is a function of type product-bi-kappa. We investigate the effects of the non-thermal features and of the anisotropy associated with this type of distribution on the ion-cyclotron instability, as well as the influence of different forms of the electron distribution, by considering Maxwellian distributions, bi-kappa distributions, and product-bi-kappa distributions. The cases of ions described by either Maxwellian or bi-kappa distributions are also considered, for comparison. The results of the numerical analysis show that the increase inmore » the non-thermal character associated with the anisotropic kappa distributions for ions contributes to enhance the instability as compared to that obtained in the Maxwellian case, in magnitude and in wave number range, with more significant enhancement for the case of ion product-bi-kappa distributions than for the case of ion bi-kappa distributions. It is also shown that the ion-cyclotron instability is decreased if the electrons are described by product-bi-kappa distributions, while electrons described by bi-kappa distributions lead to growth rates which are very similar to those obtained considering a Maxwellian distribution for the electron population.« less

  6. The Correlation between Angle Kappa and Ocular Biometry in Koreans

    PubMed Central

    Choi, Se Rang

    2013-01-01

    Purpose To investigate normative angle kappa data and to examine whether correlations exist between angle kappa and ocular biometric measurements (e.g., refractive error, axial length) and demographic features in Koreans. Methods Data from 436 eyes (213 males and 223 females) were analyzed in this study. The angle kappa was measured using Orbscan II. We used ocular biometric measurements, including refractive spherical equivalent, interpupillary distance and axial length, to investigate the correlations between angle kappa and ocular biometry. The IOL Master ver. 5.02 was used to obtain axial length. Results The mean patient age was 57.5 ± 12.0 years in males and 59.4 ± 12.4 years in females (p = 0.11). Angle kappa averaged 4.70 ± 2.70 degrees in men and 4.89 ± 2.14 degrees in women (p = 0.48). Axial length and spherical equivalent were correlated with angle kappa (r = -0.342 and r = 0.197, respectively). The correlation between axial length and spherical equivalent had a negative correlation (r = -0.540, p < 0.001). Conclusions Angle kappa increased with spherical equivalent and age. Thus, careful manipulation should be considered in older and hyperopic patients when planning refractive or strabismus surgery. PMID:24311927

  7. Inhibition of single Shaker K channels by kappa-conotoxin-PVIIA.

    PubMed Central

    Naranjo, David

    2002-01-01

    kappa-Conotoxin-PVIIA (kappa-PVIIA) is a 27-residue basic (+4) peptide from the venom of the predator snail Conus purpurascens. A single kappa-PVIIA molecule interrupts ion conduction by binding to the external mouth of Shaker K channels. The blockade of Shaker by kappa-PVIIA was studied at the single channel level in membrane patches from Xenopus oocytes. The amplitudes of blocked and closed events were undistinguishable, suggesting that the toxin interrupts ion conduction completely. Between -20 and 40 mV kappa-PVIIA increased the latency to the first opening by one order of magnitude in a concentration-independent fashion. Because kappa-PVIIA has higher affinity for the closed channels at high enough concentration to block >90% of the resting channels, the dissociation rate could be estimated from the analysis of the first latency. At 0 mV, the dissociation rate was 20 s(-1) and had an effective valence of 0.64. The apparent closing rate increased linearly with [kappa-PVIIA] indicating an association rate of 56 microM(-1) s(-1). The toxin did not modify the fraction of null traces. This result suggests that the structural rearrangements in the external mouth contributing to the slow inactivation preserve the main geometrical features of the toxin-receptor interaction. PMID:12023223

  8. c-rel activates but v-rel suppresses transcription from kappa B sites.

    PubMed Central

    Inoue, J; Kerr, L D; Ransone, L J; Bengal, E; Hunter, T; Verma, I M

    1991-01-01

    We show that the product of the protooncogene c-rel is a constituent of an NF-kappa B-like complex that binds to the kappa B site originally identified in the enhancer of immunoglobulin kappa light chain gene. c-rel protein synthesized in bacteria binds to the kappa B site in a sequence-specific manner. The rel-kappa B complex can be disrupted by incubation with anti-rel antibodies. The rel protein can form oligomers. The c-rel protein can activate transcription from promoters containing kappa B sites; v-rel, on the other hand, suppresses the transcription of genes linked to kappa B sites. Thus, v-rel may interfere with the normal transcriptional machinery of the cell by acting as a dominant negative mutant. Images PMID:2023921

  9. 20 CFR 725.218 - Conditions of entitlement; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Is determined to have died due to pneumoconiosis; or (2) Filed...

  10. 20 CFR 725.219 - Duration of entitlement; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Duration of entitlement; child. 725.219... of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning... month in which any one of the following events first occurs: (1) The child dies; (2) The child marries...

  11. 20 CFR 725.219 - Duration of entitlement; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Duration of entitlement; child. 725.219... of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning... month in which any one of the following events first occurs: (1) The child dies; (2) The child marries...

  12. 20 CFR 725.219 - Duration of entitlement; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Duration of entitlement; child. 725.219... of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning... month in which any one of the following events first occurs: (1) The child dies; (2) The child marries...

  13. 20 CFR 725.219 - Duration of entitlement; child.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Duration of entitlement; child. 725.219... of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning... month in which any one of the following events first occurs: (1) The child dies; (2) The child marries...

  14. 20 CFR 725.219 - Duration of entitlement; child.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; child. 725.219... of entitlement; child. (a) An individual is entitled to benefits as a child for each month beginning... month in which any one of the following events first occurs: (1) The child dies; (2) The child marries...

  15. Bis(acesulfamato-kappaO4)diaquabis(3-methylpyridine-kappaN)nickel(II).

    PubMed

    Dege, Necmi; Içbudak, Hasan; Adiyaman, Elif

    2007-01-01

    In the crystal structure of the title compound [systematic name: diaquabis(6-methyl-2,2-dioxo-1,2,3-oxathiazin-4-olato-kappaO4)bis(3-methylpyridine-kappaN)nickel(II)], [Ni(C4H4NO4S)2(C6H7N)2(H2O)2], the Ni(II) centre resides on a centre of symmetry and has a distorted octahedral geometry. The basal plane is formed by two carbonyl O atoms of two monodentate trans-oriented acesulfamate ligands and two trans aqua ligands. The axial positions in the octahedron are occupied by two N atoms of two trans pyridine ligands. Molecules are stacked in columns running along the a axis. There are pi-pi stacking interactions between the molecules in each column, with a distance of 3.623 (2) A between the centroids of the pyridine rings. There are also O-H...O interactions between the columns.

  16. 20 CFR 725.228 - Effect of conviction of felonious and intentional homicide on entitlement to benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... intentional homicide on entitlement to benefits. 725.228 Section 725.228 Employees' Benefits EMPLOYMENT... intentional homicide on entitlement to benefits. An individual who has been convicted of the felonious and intentional homicide of a miner or other beneficiary shall not be entitled to receive any benefits payable...

  17. 20 CFR 725.421 - Referral of a claim to the Office of Administrative Law Judges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Referral of a claim to the Office of Administrative Law Judges. 725.421 Section 725.421 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED CLAIMS FOR BENEFITS UNDER PART C OF TITLE IV OF THE FEDERAL MINE...

  18. 20 CFR 725.218 - Conditions of entitlement; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Was receiving benefits under section 415 or part C of title IV...

  19. 20 CFR 725.208 - Determination of relationship; child.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary is...

  20. 20 CFR 725.218 - Conditions of entitlement; child.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Was receiving benefits under section 415 or part C of title IV...

  1. 20 CFR 725.208 - Determination of relationship; child.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary is...

  2. 20 CFR 725.208 - Determination of relationship; child.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary is...

  3. 20 CFR 725.208 - Determination of relationship; child.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary is...

  4. 20 CFR 725.218 - Conditions of entitlement; child.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Was receiving benefits under section 415 or part C of title IV...

  5. 20 CFR 725.218 - Conditions of entitlement; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Was receiving benefits under section 415 or part C of title IV...

  6. 20 CFR 725.208 - Determination of relationship; child.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary is...

  7. Nuclear factor kappa B: a potential target for anti-HIV chemotherapy.

    PubMed

    Pande, V; Ramos, M J

    2003-08-01

    The Nuclear Factor Kappa B (NF-kappaB) is a lymphoid-specific transcription factor, which is sequestered in the cytoplasm by the protein IkappaB. NF-kappaB plays a major role in the regulation of HIV-1 gene expression. Upon activation, NF-kappaB is released from IkappaB, moves to the nucleus, and binds to its sites on the HIV long terminal repeat to start transcription of integrated HIV genome. The present review focuses on the NF-kappaB as a potential target for the development of chemotherapy against HIV-1. Beginning from the viral-binding to reverse transcription, integration, and gene expression, to the virion maturation, the life cycle of HIV presents drug-targets at all the stages. As a result, many drugs have been developed and have entered clinical trials. Some of the most important of these are reverse transcriptase and protease inhibitors, which have been used mostly in clinical studies in the form of combined therapy. But, this combined therapy has presented the problem of resistance, due to mutations in the virus. However, targeting NF-kappaB for the suppression of virus does not present the problem of resistance, as NF-kappaB is a normal part of the human T-4 cell, and is not subject to mutations, as is the virus. An overview of the NF-kappaB system and its role in HIV-1 is presented, followed by a critical review of its current and potential synthetic inhibitors. The drugs studied against NF-kappaB fall mainly into three categories: (1) Antioxidants, against oxidative stress conditions, which aid in NF-kappaB activation, (2) IkappaB phosphorylation and degradation inhibitors (the phosphorylation and degradation of IkappaB is necessary to make NF-kappaB free and move to the nucleus), and (3) NF-kappaB DNA binding inhibitors. The antioxidants include N-Acetyl-L-cysteine (NAC), alpha-Lipoic acid, glutathione monoester, pyrrolidine dithiocarbamate, and tepoxalin, of which NAC is the best studied. The IkappaB phosphorylation and degradation inhibitors

  8. 40 CFR 725.422 - Physical containment and control technologies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Physical containment and control... Exemptions for New Microorganisms § 725.422 Physical containment and control technologies. The manufacturer must meet all of the following criteria for physical containment and control technologies for any...

  9. 40 CFR 725.422 - Physical containment and control technologies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Physical containment and control... Exemptions for New Microorganisms § 725.422 Physical containment and control technologies. The manufacturer must meet all of the following criteria for physical containment and control technologies for any...

  10. 40 CFR 725.422 - Physical containment and control technologies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Physical containment and control... Exemptions for New Microorganisms § 725.422 Physical containment and control technologies. The manufacturer must meet all of the following criteria for physical containment and control technologies for any...

  11. 40 CFR 725.422 - Physical containment and control technologies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Physical containment and control... Exemptions for New Microorganisms § 725.422 Physical containment and control technologies. The manufacturer must meet all of the following criteria for physical containment and control technologies for any...

  12. Involvement of nuclear factor {kappa}B in platelet CD40 signaling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hachem, Ahmed; Yacoub, Daniel; Centre Hospitalier Universite de Montreal, 264 boul. Rene-Levesque est, Montreal, Quebec, Canada H2X 1P1

    Highlights: Black-Right-Pointing-Pointer sCD40L induces TRAF2 association to CD40 and NF-{kappa}B activation in platelets. Black-Right-Pointing-Pointer I{kappa}B{alpha} phosphorylation downstream of CD40L/CD40 signaling is independent of p38 MAPK phosphorylation. Black-Right-Pointing-Pointer I{kappa}B{alpha} is required for sCD40L-induced platelet activation and potentiation of aggregation. -- Abstract: CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular events. Platelets constitute the major source of soluble CD40L (sCD40L), which has been shown to potentiate platelet activation and aggregation, in a CD40-dependent manner, via p38 mitogen activated protein kinase (MAPK) and Rac1 signaling. In many cells, the CD40L/CD40 dyad also induces activation of nuclear factor kappa B (NF-{kappa}B). Givenmore » that platelets contain NF-{kappa}B, we hypothesized that it may be involved in platelet CD40 signaling and function. In human platelets, sCD40L induces association of CD40 with its adaptor protein the tumor necrosis factor receptor associated factor 2 and triggers phosphorylation of I{kappa}B{alpha}, which are abolished by CD40L blockade. Inhibition of I{kappa}B{alpha} phosphorylation reverses sCD40L-induced I{kappa}B{alpha} phosphorylation without affecting p38 MAPK phosphorylation. On the other hand, inhibition of p38 MAPK phosphorylation has no effect on I{kappa}B{alpha} phosphorylation, indicating a divergence in the signaling pathway originating from CD40 upon its ligation. In functional studies, inhibition of I{kappa}B{alpha} phosphorylation reverses sCD40L-induced platelet activation and potentiation of platelet aggregation in response to a sub-threshold concentration of collagen. This study demonstrates that the sCD40L/CD40 axis triggers NF-{kappa}B activation in platelets. This signaling pathway plays a critical role in platelet activation and aggregation upon sCD40L stimulation and may represent an important target against

  13. Direct covalent modification as a strategy to inhibit nuclear factor-kappa B.

    PubMed

    Pande, Vineet; Sousa, Sérgio F; Ramos, Maria João

    2009-01-01

    Nuclear Factor-KkappaB (NF-kappaB) is a transcription factor whose inappropriate activation may result in the development of a number of diseases including cancer, inflammation, neurodegeneration and AIDS. Recent studies on NF-kappaB mediated pathologies, made therapeutic interventions leading to its inhibition an emerging theme in pharmaceutical research. NF-kappaB resides in the cytoplasm and is activated by several time-dependent factors, leading to proteasome-dependent degradation of its inhibitory protein (IkappaB), resulting in free NF-kappaB (p50 and p65 subunits, involved in disease states), which binds to target DNA sites, further resulting in enhanced transcription of several disease associated proteins. The complex pathway of NF-kappaB, finally leading to its DNA binding, has attracted several approaches interfering with this pathway. One such approach is that of a direct covalent modification of NF-kappaB. In this article, we present a critical review on the pharmacological agents that have been studied as inhibitors of NF-kappaB by covalently modifying redox-regulated cysteine residues in its subunits, ultimately resulting in the inhibition of kappaB DNA recognition and binding. Beginning with a general overview of NF-kappaB pathway and several possibilities of chemical interventions, the significance of redox-regulation in NF-kappaB activation and DNA binding is presented. Further, protein S-thiolation, S-nitrosylation and irreversible covalent modification are described as regular biochemical events in the cell, having provided a guideline for the development of NF-kappaB inhibitors discussed further. Although just a handful of inhibitors, with most of them being alkylating agents have been studied in the present context, this approach presents potential for the development of a new class of NF-kappaB-inhibitors.

  14. 20 CFR 725.216 - Determination of relationship; surviving divorced spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... reviewed under part 727 of this subchapter (see § 725.4(d)), if such individual's marriage to the miner had been terminated by a final divorce on or after the 10th anniversary of the marriage unless, if such...

  15. 20 CFR 725.507 - Guardian for minor or incompetent.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Guardian for minor or incompetent. 725.507... for minor or incompetent. An adjudication officer may require that a legal guardian or representative be appointed to receive benefit payments payable to any person who is mentally incompetent or a minor...

  16. 12 CFR 725.17 - Applications for extensions of credit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.17 Applications for extensions of credit. (a) A Regular member may apply for a Facility advance to meet its liquidity needs by filing an... Agent by its member natural person credit unions for pending loans to meet liquidity needs; or (ii...

  17. Determination of the electromechanical coupling factor of gallium orthophosphate (GaPO4) and its influence on resonance-frequency temperature dependencies.

    PubMed

    Nosek, Jaroslav; Pustka, Martin

    2006-01-01

    The quartz homeotype gallium orthophosphate (GaPO4) is a representative of piezoelectric single crystals of large electromechanical coupling factor. It is known that its coupling factor kappa26 associated with the resonators vibrating in the thickness-shear mode is approximately two times greater than that of quartz. This property increases the spacing between the series and parallel resonance frequencies of resonators, as well as the difference between the resonance frequency temperature dependencies of the fundamental and harmonic resonance frequencies of resonators vibrating in the thickness-shear mode. In this paper, the methods for determination of the coupling factor kappa26 are presented, and the computed values are compared with the measured ones. The influence of the coupling factor to the resonance-frequency temperature dependencies of the fundamental and third harmonics of selected rotated Y-cut GaPO4 resonators vibrating in the thickness-shear mode is presented. The purely elastic case for a laterally unbounded plate, which corresponds closely to the limiting case of high harmonic resonance frequency-temperature behavior was assumed for the calculations. The computed temperature coefficients for the Y-cut orientation and calculated turnover point temperatures TTP for different (YX1) orientations are presented.

  18. Synergistic activation of NF-{kappa}B by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKK{beta}-I{kappa}B{alpha}, and p38 MAPK

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kweon, Soo-Mi; Wang, Beinan; Rixter, Davida

    2006-12-15

    In review of the past studies on NF-{kappa}B regulation, most of them have focused on investigating how NF-{kappa}B is activated by a single inducer at a time. Given the fact that, in mixed bacterial infections in vivo, multiple inflammation inducers, including both nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae, are present simultaneously, a key issue that has yet to be addressed is whether NTHi and S. pneumoniae simultaneously activate NF-{kappa}B and the subsequent inflammatory response in a synergistic manner. Here, we show that NTHi and S. pneumoniae synergistically induce NF-{kappa}B-dependent inflammatory response via activation of multiple signaling pathways in vitromore » and in vivo. The classical IKK{beta}-I{kappa}B{alpha} and p38 MAPK pathways are involved in synergistic activation of NF-{kappa}B via two distinct mechanisms, p65 nuclear translocation-dependent and -independent mechanisms. Moreover, casein kinase 2 (CK2) is involved in synergistic induction of NF-{kappa}B via a mechanism dependent on phosphorylation of p65 at both Ser536 and Ser276 sites. These studies bring new insights into the molecular mechanisms underlying the NF-{kappa}B-dependent inflammatory response in polymicrobial infections and may lead to development of novel therapeutic strategies for modulating inflammation in mixed infections for patients with otitis media and chronic obstructive pulmonary diseases.« less

  19. Kappa statistic for clustered matched-pair data.

    PubMed

    Yang, Zhao; Zhou, Ming

    2014-07-10

    Kappa statistic is widely used to assess the agreement between two procedures in the independent matched-pair data. For matched-pair data collected in clusters, on the basis of the delta method and sampling techniques, we propose a nonparametric variance estimator for the kappa statistic without within-cluster correlation structure or distributional assumptions. The results of an extensive Monte Carlo simulation study demonstrate that the proposed kappa statistic provides consistent estimation and the proposed variance estimator behaves reasonably well for at least a moderately large number of clusters (e.g., K ≥50). Compared with the variance estimator ignoring dependence within a cluster, the proposed variance estimator performs better in maintaining the nominal coverage probability when the intra-cluster correlation is fair (ρ ≥0.3), with more pronounced improvement when ρ is further increased. To illustrate the practical application of the proposed estimator, we analyze two real data examples of clustered matched-pair data. Copyright © 2014 John Wiley & Sons, Ltd.

  20. 18 CFR 725.7 - Regional or river basin planning.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Regional or river basin... Responsibilities § 725.7 Regional or river basin planning. (a) In agreements between river basin commissions or other regional planning sponsors and the Council for the preparation and revision of regional and river...

  1. 18 CFR 725.7 - Regional or river basin planning.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Regional or river basin... Responsibilities § 725.7 Regional or river basin planning. (a) In agreements between river basin commissions or other regional planning sponsors and the Council for the preparation and revision of regional and river...

  2. 20 CFR 725.214 - Determination of relationship; surviving spouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... property; or (d) Such individual went through a marriage ceremony with the miner, resulting in a purported marriage between them which, but for a legal impediment (see § 725.230), would have been a valid marriage, unless such individual entered into the purported marriage with knowledge that it was not a valid...

  3. 133. PARCEL HANDLING SPACE OF POST OFFICE BUILDING, LEVEL 72.5, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    133. PARCEL HANDLING SPACE OF POST OFFICE BUILDING, LEVEL 72.5, NORTH OF TRUCKING PASSAGE MAIL TRANSPORT AREA, VIEW TO NORTHWEST - Terminal Tower Building, Cleveland Union Terminal, 50 Public Square, Cleveland, Cuyahoga County, OH

  4. The relationship between kappa and temperature in energetic ion spectra at Jupiter

    NASA Technical Reports Server (NTRS)

    Collier, Michael R.; Hamilton, D. C.

    1995-01-01

    A universal energy per charge kappa function fit is simultaneously applied to the spectra of Voyager 2 Low Energy Charged Particle (LECP) proton, helium, oxygen, sulfur, and carbon ions during 33 Jovian plasma sheet crossings from 26 to 160 R(sub J). The fits yield an approximately linear relationship between high energy spectral index, kappa, and core proton temperature of the form kappa (T(sub H)) approximately = eta dot T(sub H) + kappa(sub 0) with eta = 0.080 ke/V, kappa(sub 0) = 2.86, and T(sub H) measured in keV. Core proton temperatures range from 5 to 35 keV with spectral indices ranging from 3 to 6.

  5. Phi Delta Kappa Viewpoint.

    ERIC Educational Resources Information Center

    Phi Delta Kappa, Trenton, NJ. Trenton Area Chapter.

    This collection of articles on aspects of educational research, service, and leadership, are all written by members the Trenton (New Jersey) Area Chapter of Phi Delta Kappa. "Extra Year Programs: The K-1 Transition," by Richard Graja, reports on a study of 210 families regarding the Extra Year program, an opportunity for children to…

  6. 40 CFR 1065.725 - High-level ethanol-gasoline blends.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false High-level ethanol-gasoline blends... Calibration Standards § 1065.725 High-level ethanol-gasoline blends. For testing vehicles capable of operating on a high-level ethanol-gasoline blend, create a test fuel as follows: (a) Add ethanol to an E10 fuel...

  7. 20 CFR 405.725 - Effect of expedited appeals process agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405.725 Effect of expedited appeals process agreement. After an expedited appeals process agreement is... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Effect of expedited appeals process agreement...

  8. 40 CFR 721.10688 - Copper, chloro[tris(2-chloroethyl) phosphite-.kappa.P]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) phosphite-.kappa.P]-. 721.10688 Section 721.10688 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Specific Chemical Substances § 721.10688 Copper, chloro[tris(2-chloroethyl) phosphite-.kappa.P]-. (a... copper, chloro[tris(2-chloroethyl) phosphite-.kappa.P]- (PMN P-13-221; CAS No. 24484-01-3) is subject to...

  9. TRIM45 negatively regulates NF-{kappa}B-mediated transcription and suppresses cell proliferation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shibata, Mio; Sato, Tomonobu; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638

    2012-06-22

    Highlights: Black-Right-Pointing-Pointer NF-{kappa}B plays an important role in cell survival and carcinogenesis. Black-Right-Pointing-Pointer TRIM45 negatively regulates TNF{alpha}-induced NF-{kappa}B-mediated transcription. Black-Right-Pointing-Pointer TRIM45 overexpression suppresses cell growth. Black-Right-Pointing-Pointer TRIM45 acts as a repressor for the NF-{kappa}B signal and regulates cell growth. -- Abstract: The NF-{kappa}B signaling pathway plays an important role in cell survival, immunity, inflammation, carcinogenesis, and organogenesis. Activation of NF-{kappa}B is regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. The NF-{kappa}B signaling pathway is activated by two distinct signaling mechanisms and is strictly modulated by the ubiquitin-proteasome system. It has been reported that overexpression of TRIM45, one ofmore » the TRIM family ubiquitin ligases, suppresses transcriptional activities of Elk-1 and AP-1, which are targets of the MAPK signaling pathway. In this study, we showed that TRIM45 also negatively regulates TNF{alpha}-induced NF-{kappa}B-mediated transcription by a luciferase reporter assay and that TRIM45 lacking a RING domain also has an activity to inhibit the NF-{kappa}B signal. Moreover, we found that TRIM45 overexpression suppresses cell growth. These findings suggest that TRIM45 acts as a repressor for the NF-{kappa}B signal and regulates cell growth.« less

  10. Measuring grain boundary character distributions in Ni-base alloy 725 using high-energy diffraction microscopy

    DOE PAGES

    Bagri, Akbar; Hanson, John P.; Lind, J. P.; ...

    2016-10-25

    We use high-energy X-ray diffraction microscopy (HEDM) to characterize the microstructure of Ni-base alloy 725. HEDM is a non-destructive technique capable of providing three-dimensional reconstructions of grain shapes and orientations in polycrystals. The present analysis yields the grain size distribution in alloy 725 as well as the grain boundary character distribution (GBCD) as a function of lattice misorientation and boundary plane normal orientation. We find that the GBCD of Ni-base alloy 725 is similar to that previously determined in pure Ni and other fcc-base metals. We find an elevated density of Σ9 and Σ3 grain boundaries. We also observe amore » preponderance of grain boundaries along low-index planes, with those along (1 1 1) planes being the most common, even after Σ3 twins have been excluded from the analysis.« less

  11. 21 CFR 172.725 - Gibberellic acid and its potassium salt.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Other Specific Usage Additives § 172.725 Gibberellic acid and its potassium salt. The food additives gibberellic acid and its...: (a) The additives meet the following specifications: (1) The gibberellic acid is produced by deep...

  12. 20 CFR 725.211 - Time of determination of relationship and dependency of spouse or child for purposes of...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Time of determination of relationship and dependency of spouse or child for purposes of augmentation of benefits. 725.211 Section 725.211 Employees... of relationship and dependency of spouse or child for purposes of augmentation of benefits. With...

  13. 20 CFR 725.211 - Time of determination of relationship and dependency of spouse or child for purposes of...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Time of determination of relationship and dependency of spouse or child for purposes of augmentation of benefits. 725.211 Section 725.211 Employees... of relationship and dependency of spouse or child for purposes of augmentation of benefits. With...

  14. 20 CFR 725.211 - Time of determination of relationship and dependency of spouse or child for purposes of...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Time of determination of relationship and dependency of spouse or child for purposes of augmentation of benefits. 725.211 Section 725.211 Employees... of relationship and dependency of spouse or child for purposes of augmentation of benefits. With...

  15. 20 CFR 725.211 - Time of determination of relationship and dependency of spouse or child for purposes of...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Time of determination of relationship and dependency of spouse or child for purposes of augmentation of benefits. 725.211 Section 725.211 Employees... of relationship and dependency of spouse or child for purposes of augmentation of benefits. With...

  16. 20 CFR 725.211 - Time of determination of relationship and dependency of spouse or child for purposes of...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Time of determination of relationship and dependency of spouse or child for purposes of augmentation of benefits. 725.211 Section 725.211 Employees... of relationship and dependency of spouse or child for purposes of augmentation of benefits. With...

  17. Clinical validation of nuclear factor kappa B expression in invasive breast cancer.

    PubMed

    Agrawal, Anil Kumar; Pielka, Ewa; Lipinski, Artur; Jelen, Michal; Kielan, Wojciech; Agrawal, Siddarth

    2018-01-01

    Breast cancer is the most commonly diagnosed cancer in Polish women. The expression of transcription nuclear factor kappa B, a key inducer of inflammatory response promoting carcinogenesis and cancer progression in breast cancer, is not well-established. We assessed the nuclear factor kappa B expression in a total of 119 invasive breast carcinomas and 25 healthy control samples and correlated this expression pattern with several clinical and pathologic parameters including histologic type and grade, tumor size, lymph node status, estrogen receptor status, and progesterone receptor status. The data used for the analysis were derived from medical records. An immunohistochemical analysis of nuclear factor kappa B, estrogen receptor, and progesterone receptor was carried out and evaluation of stainings was performed. The expression of nuclear factor kappa B was significantly higher than that in the corresponding healthy control samples. No statistical difference was demonstrated in nuclear factor kappa B expression in relation to age, menopausal status, lymph node status, tumor size and location, grade and histologic type of tumor, and hormonal status (estrogen receptor and progesterone receptor). Nuclear factor kappa B is significantly overexpressed in invasive breast cancer tissues. Although nuclear factor kappa B status does not correlate with clinicopathological findings, it might provide important additional information on prognosis and become a promising object for targeted therapy.

  18. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NF{kappa}B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Eliseev, Roman A.; Schwarz, Edward M.; Zuscik, Michael J.

    2006-01-01

    The transcription factor NF{kappa}B is constitutively activated in various tumor cells where it promotes proliferation and represses apoptosis. The bone morphogenetic proteins (BMPs) delay cell proliferation and promote differentiation and apoptosis of bone cells through activation of Smad downstream effectors and via Smad-independent mechanisms. Thus, NF{kappa}B and BMP pathways play opposing roles in regulating osteoblastic cell fate. Here, we show that in osteosarcoma Saos2 osteoblasts, NF{kappa}B regulates the activity of the BMP/Smad signaling. Inhibition of NF{kappa}B by overexpression of mI{kappa}B leads to the induction of osteoblast differentiation. Saos2 cells overexpressing mI{kappa}B (Saos2-mI{kappa}B) exhibit higher expression of osteoblast phenotypic genes suchmore » as alkaline phosphatase, Runx2 and osteocalcin and are more responsive to BMP2 in comparison to wild-type cells (Saos2-wt) or empty vector infected controls (Saos2-EV). Furthermore, BMP-2 signaling and Smad phosphorylation are significantly increased in Saos2-mI{kappa}B cells in comparison to Saos2-EV cells. Inhibition of NF{kappa}B signaling in Saos2-mI{kappa}B cells is associated with decreased expression of the BMP signaling inhibitor Smad7. While gain of Smad7 function in Saos2-mI{kappa}B cells results in inhibition of BMP signaling, anti-sense knockdown of Smad7 in Saos2-EV cells leads to upregulation of BMP signaling. We therefore conclude that in osteosarcoma Saos2 cells, NF{kappa}B represses BMP/Smad signaling and BMP2-induced differentiation through Smad7.« less

  19. NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice.

    PubMed

    Freudenthal, Ramiro; Boccia, Mariano M; Acosta, Gabriela B; Blake, Mariano G; Merlo, Emiliano; Baratti, Carlos M; Romano, Arturo

    2005-05-01

    Although it is generally accepted that memory consolidation requires regulation of gene expression, only a few transcription factors (TFs) have been clearly demonstrated to be specifically involved in this process. Increasing research data point to the participation of the Rel/nuclear factor-kappaB (NF-kappaB) family of TFs in memory and neural plasticity. Here we found that two independent inhibitors of NF-kappaB induced memory impairment in the one-trial step-through inhibitory avoidance paradigm in mice: post-training administration of the drug sulfasalazine and 2 h pretraining administration of a double-stranded DNA oligonucleotide containing the NF-kappaB consensus sequence (kappaB decoy). Conversely, one base mutation of the kappaB decoy (mut-kappaB decoy) injection did not affect long-term memory. Accordingly, the kappaB decoy inhibited NF-kappaB in hippocampus 2 h after injection but no inhibition was found with mut-kappaB decoy administration. A temporal course of hippocampal NF-kappaB activity after training was determined. Unexpectedly, an inhibition of NF-kappaB was found 15 min after training in shocked and unshocked groups when compared with the naïve group. Hippocampal NF-kappaB was activated 45 min after training in both shocked and unshocked groups, decreasing 1 h after training and returning to basal levels 2 and 4 h after training. On the basis of the latter results, we propose that activation of NF-kappaB in hippocampus is part of the molecular mechanism involved in the storage of contextual features that constitute the conditioned stimulus representation. The results presented here provide the first evidence to support NF-kappaB activity being regulated in hippocampus during consolidation, stressing the role of this TF as a conserved molecular mechanism for memory storage.

  20. 40 CFR 725.975 - EPA approval of alternative control measures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA approval of alternative control... Procedures for Reporting on Significant New Uses of Microorganisms § 725.975 EPA approval of alternative... which EPA has determined provide substantially the same degree of protection as the specified control...

  1. 40 CFR 725.370 - EPA review of the TME application.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... unreasonable risk of injury to health and the environment as a result of test marketing. ... Marketing § 725.370 EPA review of the TME application. General procedures for review of all submissions... with test marketing activities after receipt of EPA approval. (c) In approving a TME application, EPA...

  2. 21 CFR 172.725 - Gibberellic acid and its potassium salt.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Other Specific Usage Additives § 172.725 Gibberellic acid and its potassium salt. The food additives gibberellic acid and its potassium salt may be used in the malting of barley in...

  3. 21 CFR 172.725 - Gibberellic acid and its potassium salt.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Other Specific Usage Additives § 172.725 Gibberellic acid and its potassium salt. The food additives gibberellic acid and its potassium salt may be used in the malting of barley in...

  4. Purinergic signaling is required for fluid shear stress-induced NF-{kappa}B translocation in osteoblasts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Genetos, Damian C., E-mail: dgenetos@ucdavis.edu; Karin, Norman J.; Geist, Derik J.

    2011-04-01

    Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-{kappa}B. We examined whether this process was under the control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-{kappa}B inhibitory protein I{kappa}B{alpha} and exhibited cytosolic localization of NF-{kappa}B. Under fluid shear stress, I{kappa}B{alpha} levels decreased, and concomitant nuclear localization of NF-{kappa}B was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I{kappa}B{alpha}, and NF-{kappa}B remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X{sub 7} receptor antagonists, indicating that themore » P2X{sub 7} receptor is responsible for fluid shear-stress-induced I{kappa}B{alpha} degradation and nuclear accumulation of NF-{kappa}B. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced I{kappa}B{alpha} degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X{sub 7}-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-{kappa}B activity through the P2Y{sub 6} and P2X{sub 7} receptor.« less

  5. Measuring agreement of multivariate discrete survival times using a modified weighted kappa coefficient.

    PubMed

    Guo, Ying; Manatunga, Amita K

    2009-03-01

    Assessing agreement is often of interest in clinical studies to evaluate the similarity of measurements produced by different raters or methods on the same subjects. We present a modified weighted kappa coefficient to measure agreement between bivariate discrete survival times. The proposed kappa coefficient accommodates censoring by redistributing the mass of censored observations within the grid where the unobserved events may potentially happen. A generalized modified weighted kappa is proposed for multivariate discrete survival times. We estimate the modified kappa coefficients nonparametrically through a multivariate survival function estimator. The asymptotic properties of the kappa estimators are established and the performance of the estimators are examined through simulation studies of bivariate and trivariate survival times. We illustrate the application of the modified kappa coefficient in the presence of censored observations with data from a prostate cancer study.

  6. NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach.

    PubMed

    Amit, Sharon; Ben-Neriah, Yinon

    2003-02-01

    Nuclear factor-kappa B (NF-kappaB) activation relies primarily on ubiquitin-mediated degradation of its inhibitor IkappaB. NF-kappaB plays an important role in many aspects of tumor development, progression, and therapy. Some types of cancer are characterized by constitutive NF-kappaB activity, whereas in others such activity is induced following chemotherapy. NF-kappaB-harboring tumors are generally resistant to chemotherapy and their eradication requires NF-kappaB inhibition. Here we describe the mechanisms of NF-kappaB activation in normal and tumor cells, review prevalent notions regarding the factor's contribution to tumorigenicity and discuss present and future options for NF-kappaB inhibition in cancer. The ubiquitination-mediated activation of NF-kappaB is intersected by another cancer-associated protein, beta-catenin. We, therefore, compare the related activation pathways and discuss the possibility of differential targeting of the involved ubiquitination machinery. Copyright 2002 Elsevier Science Ltd.

  7. 77 FR 39691 - Commission Information Collection Activities (FERC-725); Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... information collection FERC-725, Certification of Electric Reliability Organization; Procedures for Electric Reliability Standards, to the Office of Management and Budget (OMB) for review of the information collection..., Certification of Electric Reliability Organization; Procedures for Electric Reliability Standards. OMB Control...

  8. Calculation of strange resonances from Kπ scattering

    NASA Astrophysics Data System (ADS)

    Rodas, A.; Peláez, J. R.; Ruiz de Elvira, J.

    2017-09-01

    We present a determination of the mass, width and coupling of the strange resonances appearing in pion-kaon scattering below 1.8 GeV, namely the much debated $K^*_0(800)$ or $\\kappa$, the scalar $K^*_0(1430)$, the $K^*(892)$ and $K^*(1410)$ vectors, the spin-two $K^*_2(1430)$ as well as the spin-three $K^*_3(1780)$. The parameters of each resonance are determined using a direct analytic continuation of the pion-kaon partial waves by means of Pad\\'e approximants, thus avoiding any particular model description of their pole positions and residues, while taking into account the analytic requirements imposed by dispersion relations.

  9. 40 CFR 725.29 - EPA acknowledgement of receipt of submission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false EPA acknowledgement of receipt of... Procedures § 725.29 EPA acknowledgement of receipt of submission. (a) EPA will acknowledge receipt of each... Toxics Document Control Officer. (b) The acknowledgement does not constitute a finding by EPA that the...

  10. Mechanisms for kappa reduction and color removal by xylanases

    Treesearch

    Thomas W. Jeffries; Mark Davis; Brian Rosin; Larry L. Landucci

    1998-01-01

    Xylanases reduce kappa and release UV- and visibly absorptive materials from kraft pulps. The extents of these actions depend on the origin and processing of the pulp, access of enzymes to the substrate, and the natures of the enzymes. Hexeneuronic acid (HexA) is a component of kraft pulp xylans that accounts for a fraction of the kappa content. It absorbs strongly in...

  11. Ion and electron Kappa distribution functions in the plasma sheet.

    NASA Astrophysics Data System (ADS)

    Moya, P. S.; Stepanova, M. V.; Espinoza, C.; Antonova, E. E.; Valdivia, J. A.

    2017-12-01

    We present a study of ion and electron flux spectra in the Earth's plasma sheet using kappa distribution functions. Satellite data from the THEMIS mission were collected for thousands of crossings through the plasma sheet, between 7 and 35 Re and during the years 2008-2009. The events were separated according to the geomagnetic activity at the time. Our results show the distribution of the kappa index and characteristic energies across the plasma sheet and its evolution with distance to Earth for quiet times and for the substorm expansion and recovery phases. For the ions, it is observed that the kappa values tend to decrease outwards and that this effect is more significant in the dusk sector, where the smallest values are found for distances beyond 15 Re. The main effect of the substorms appears as an enhancement of this behavior. The electrons show a much more homogeneous distribution in quiet times, with a mild tendency for larger kappa values at larger distances. During substorms, the kappa values tend to equalize and appear very homogenous during expansion. However, they exhibit a significant increase in the dusk sector during the recovery substorm phase. Finally, we observe that the characteristic energy of the particles during substorms increases and concentrate at distances less than 15 Re.

  12. Cohen's Linearly Weighted Kappa Is a Weighted Average of 2 x 2 Kappas

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2011-01-01

    An agreement table with [n as an element of N is greater than or equal to] 3 ordered categories can be collapsed into n - 1 distinct 2 x 2 tables by combining adjacent categories. Vanbelle and Albert ("Stat. Methodol." 6:157-163, 2009c) showed that the components of Cohen's weighted kappa with linear weights can be obtained from these n - 1…

  13. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.

    PubMed

    Baud, Véronique; Karin, Michael

    2009-01-01

    Nuclear factor kappaB (NF-kappaB) transcription factors have a key role in many physiological processes such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF-kappaB and the signalling pathways that control its activity are involved in cancer development and progression, as well as in resistance to chemotherapy and radiotherapy. This article discusses recent evidence from cancer genetics and cancer genome studies that support the involvement of NF-kappaB in human cancer, particularly in multiple myeloma. The therapeutic potential and benefit of targeting NF-kappaB in cancer, and the possible complications and pitfalls of such an approach, are explored.

  14. 20 CFR 404.725 - Evidence of a valid ceremonial marriage.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Evidence of a valid ceremonial marriage. 404... DISABILITY INSURANCE (1950- ) Evidence Evidence of Age, Marriage, and Death § 404.725 Evidence of a valid ceremonial marriage. (a) General. A valid ceremonial marriage is one that follows procedures set by law in...

  15. 40 CFR 725.975 - EPA approval of alternative control measures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Additional... EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software in the manner set forth in § 725.25(c). See 40 CFR 720.40(a)(2)(iv) for information on how to obtain e-PMN software. Support...

  16. 40 CFR 725.975 - EPA approval of alternative control measures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Additional... EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software in the manner set forth in § 725.25(c). See 40 CFR 720.40(a)(2)(iv) for information on how to obtain e-PMN software. Support...

  17. 40 CFR 725.975 - EPA approval of alternative control measures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Additional... EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software in the manner set forth in § 725.25(c). See 40 CFR 720.40(a)(2)(iv) for information on how to obtain e-PMN software. Support...

  18. Nomogram for sample size calculation on a straightforward basis for the kappa statistic.

    PubMed

    Hong, Hyunsook; Choi, Yunhee; Hahn, Seokyung; Park, Sue Kyung; Park, Byung-Joo

    2014-09-01

    Kappa is a widely used measure of agreement. However, it may not be straightforward in some situation such as sample size calculation due to the kappa paradox: high agreement but low kappa. Hence, it seems reasonable in sample size calculation that the level of agreement under a certain marginal prevalence is considered in terms of a simple proportion of agreement rather than a kappa value. Therefore, sample size formulae and nomograms using a simple proportion of agreement rather than a kappa under certain marginal prevalences are proposed. A sample size formula was derived using the kappa statistic under the common correlation model and goodness-of-fit statistic. The nomogram for the sample size formula was developed using SAS 9.3. The sample size formulae using a simple proportion of agreement instead of a kappa statistic and nomograms to eliminate the inconvenience of using a mathematical formula were produced. A nomogram for sample size calculation with a simple proportion of agreement should be useful in the planning stages when the focus of interest is on testing the hypothesis of interobserver agreement involving two raters and nominal outcome measures. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.

    PubMed

    Ansonoff, Michael A; Wen, Ting; Pintar, John E

    2010-01-01

    Over the past several years substantial evidence has documented that opioid receptor homo- and heterodimers form in cell lines expressing one or more of the opioid receptors. We used opioid receptor knockout mice to determine whether in vivo pharmacological characteristics of kappa1 and kappa2 opioid receptors changed following knockout of specific opioid receptors. Using displacement of the general opioid ligand diprenorphine, we observed that occupancy or knockout of the DOR-1 gene increases the binding density of kappa1 receptors and eliminates kappa2 receptors in crude membrane preparations while the total density of kappa opioid binding sites is unchanged. Further, the analgesic potency of U69,593 in cumulative dose response curves is enhanced in mice lacking the DOR-1 gene. These results demonstrate that the DOR-1 gene is required for the expression of the kappa2 opioid receptor subtype and are consistent with the possibility that a KOR-1/DOR-1 heterodimer mediates kappa2 pharmacology.

  20. 40 CFR 725.205 - Persons who may report under this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for Research and Development Activities § 725.205 Persons who may report under this subpart. (a) Commercial research and development activities involving new microorganisms or significant new uses of...) Commercial purposes for research and development means that the activities are conducted with the purpose of...

  1. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  2. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  3. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  4. Salicylates inhibit flavivirus replication independently of blocking nuclear factor kappa B activation.

    PubMed

    Liao, C L; Lin, Y L; Wu, B C; Tsao, C H; Wang, M C; Liu, C I; Huang, Y L; Chen, J H; Wang, J P; Chen, L K

    2001-09-01

    Flaviviruses comprise a positive-sense RNA genome that replicates exclusively in the cytoplasm of infected cells. Whether flaviviruses require an activated nuclear factor(s) to complete their life cycle and trigger apoptosis in infected cells remains elusive. Flavivirus infections quickly activate nuclear factor kappa B (NF-kappaB), and salicylates have been shown to inhibit NF-kappaB activation. In this study, we investigated whether salicylates suppress flavivirus replication and virus-induced apoptosis in cultured cells. In a dose-dependent inhibition, we found salicylates within a range of 1 to 5 mM not only restricted flavivirus replication but also abrogated flavivirus-triggered apoptosis. However, flavivirus replication was not affected by a specific NF-kappaB peptide inhibitor, SN50, and a proteosome inhibitor, lactacystin. Flaviviruses also replicated and triggered apoptosis in cells stably expressing IkappaBalpha-DeltaN, a dominant-negative mutant that antagonizes NF-kappaB activation, as readily as in wild-type BHK-21 cells, suggesting that NF-kappaB activation is not essential for either flavivirus replication or flavivirus-induced apoptosis. Salicylates still diminished flavivirus replication and blocked apoptosis in the same IkappaBalpha-DeltaN cells. This inhibition of flaviviruses by salicylates could be partially reversed by a specific p38 mitogen-activated protein (MAP) kinase inhibitor, SB203580. Together, these results show that the mechanism by which salicylates suppress flavivirus infection may involve p38 MAP kinase activity but is independent of blocking the NF-kappaB pathway.

  5. 40 CFR 725.190 - Notice of commencement of manufacture or import.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Notice of commencement of manufacture... Microbial Commercial Activities Notification Requirements § 725.190 Notice of commencement of manufacture or import. (a) Applicability. Any person who commences the manufacture or import of a new microorganism for...

  6. 40 CFR 725.255 - Information to be included in the TERA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., geographical, physical, chemical, and biological features, proximity to human habitation or activity, and... of the activity. (ii) Mitigation and emergency procedures. (iii) Measures to detect and control... and Development Activities § 725.255 Information to be included in the TERA. (a) To review a TERA, EPA...

  7. 40 CFR 725.255 - Information to be included in the TERA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., geographical, physical, chemical, and biological features, proximity to human habitation or activity, and... of the activity. (ii) Mitigation and emergency procedures. (iii) Measures to detect and control... and Development Activities § 725.255 Information to be included in the TERA. (a) To review a TERA, EPA...

  8. 40 CFR 725.255 - Information to be included in the TERA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., geographical, physical, chemical, and biological features, proximity to human habitation or activity, and... of the activity. (ii) Mitigation and emergency procedures. (iii) Measures to detect and control... and Development Activities § 725.255 Information to be included in the TERA. (a) To review a TERA, EPA...

  9. 40 CFR 725.255 - Information to be included in the TERA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., geographical, physical, chemical, and biological features, proximity to human habitation or activity, and... of the activity. (ii) Mitigation and emergency procedures. (iii) Measures to detect and control... and Development Activities § 725.255 Information to be included in the TERA. (a) To review a TERA, EPA...

  10. Mitochondria mediate tumor necrosis factor-alpha/NF-kappaB signaling in skeletal muscle myotubes

    NASA Technical Reports Server (NTRS)

    Li, Y. P.; Atkins, C. M.; Sweatt, J. D.; Reid, M. B.; Hamilton, S. L. (Principal Investigator)

    1999-01-01

    Tumor necrosis factor-alpha (TNF-alpha) is implicated in muscle atrophy and weakness associated with a variety of chronic diseases. Recently, we reported that TNF-alpha directly induces muscle protein degradation in differentiated skeletal muscle myotubes, where it rapidly activates nuclear factor kappaB (NF-kappaB). We also have found that protein loss induced by TNF-alpha is NF-kappaB dependent. In the present study, we analyzed the signaling pathway by which TNF-alpha activates NF-kappaB in myotubes differentiated from C2C12 and rat primary myoblasts. We found that activation of NF-kappaB by TNF-alpha was blocked by rotenone or amytal, inhibitors of complex I of the mitochondrial respiratory chain. On the other hand, antimycin A, an inhibitor of complex III, enhanced TNF-alpha activation of NK-kappaB. These results suggest a key role of mitochondria-derived reactive oxygen species (ROS) in mediating NF-kappaB activation in muscle. In addition, we found that TNF-alpha stimulated protein kinase C (PKC) activity. However, other signal transduction mediators including ceramide, Ca2+, phospholipase A2 (PLA2), and nitric oxide (NO) do not appear to be involved in the activation of NF-kappaB.

  11. Chronic intermittent hypoxia activates nuclear factor-{kappa}B in cardiovascular tissues in vivo

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Greenberg, Harly; Ye Xiaobing; Wilson, David

    2006-05-05

    Obstructive sleep apnea (OSA) is an important risk factor for cardiovascular morbidity and mortality. The mechanisms through which OSA promotes the development of cardiovascular disease are poorly understood. In this study, we tested the hypotheses that chronic exposure to intermittent hypoxia and reoxygenation (CIH) is a major pathologic factor causing cardiovascular inflammation, and that CIH-induces cardiovascular inflammation and pathology by activating the NF-{kappa}B pathway. We demonstrated that exposure of mice to CIH activated NF-{kappa}B in cardiovascular tissues, and that OSA patients had markedly elevated monocyte NF-{kappa}B activity, which was significantly decreased when obstructive apneas and their resultant CIH were eliminatedmore » by nocturnal CPAP therapy. The elevated NF-{kappa}B activity induced by CIH is accompanied by and temporally correlated to the increased expression of iNOS protein, a putative and important NF-{kappa}B-dependent gene product. Thus, CIH-mediated NF-{kappa}B activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients.« less

  12. EWS-FLI1 inhibits TNF{alpha}-induced NF{kappa}B-dependent transcription in Ewing sarcoma cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lagirand-Cantaloube, Julie, E-mail: julie.cantaloube@crbm.cnrs.fr; Laud, Karine, E-mail: karine.laud@curie.fr; Institut Curie, Genetique et biologie des cancers, Paris

    2010-09-03

    Research highlights: {yields} EWS-FLI1 interferes with TNF-induced activation of NF{kappa}B in Ewing sarcoma cells. {yields} EWS-FLI1 knockdown in Ewing sarcoma cells increases TNF-induced NF{kappa}B binding to DNA. {yields} EWS-FLI1 reduces TNF-stimulated NF{kappa}B-dependent transcriptional activation. {yields} Constitutive NF{kappa}B activity is not affected by EWS-FLI1. {yields} EWS-FLI1 physically interacts with NF{kappa}B p65 in vivo. -- Abstract: Ewing sarcoma is primarily caused by a t(11;22) chromosomal translocation encoding the EWS-FLI1 fusion protein. To exert its oncogenic function, EWS-FLI1 acts as an aberrant transcription factor, broadly altering the gene expression profile of tumor cells. Nuclear factor-kappaB (NF{kappa}B) is a tightly regulated transcription factor controllingmore » cell survival, proliferation and differentiation, as well as tumorigenesis. NF{kappa}B activity is very low in unstimulated Ewing sarcoma cells, but can be induced in response to tumor necrosis factor (TNF). We wondered whether NF{kappa}B activity could be modulated by EWS-FLI1 in Ewing sarcoma. Using a knockdown approach in Ewing sarcoma cells, we demonstrated that EWS-FLI1 has no influence on NF{kappa}B basal activity, but impairs TNF-induced NF{kappa}B-driven transcription, at least in part through inhibition of NF{kappa}B binding to DNA. We detected an in vivo physical interaction between the fusion protein and NF{kappa}B p65, which could mediate these effects. Our findings suggest that, besides directly controlling the activity of its primary target promoters, EWS-FLI1 can also indirectly influence gene expression in tumor cells by modulating the activity of key transcription factors such as NF{kappa}B.« less

  13. Regulation of NF-{kappa}B activity in astrocytes: effects of flavonoids at dietary-relevant concentrations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spilsbury, Alison; Vauzour, David; Spencer, Jeremy P.E.

    Highlights: Black-Right-Pointing-Pointer We tested the hypothesis that low concentrations of flavonoids inhibit NF-{kappa}B in astrocytes. Black-Right-Pointing-Pointer Primary cultured astrocytes possess a functional {kappa}B-system, measured using luciferase assays. Black-Right-Pointing-Pointer Seven flavonoids (100 nM-1 {mu}M) failed to reduce NF-{kappa}B activity in astrocytes. Black-Right-Pointing-Pointer Four flavonoids (100 nM-1 {mu}M) failed to reduce TNFa-stimulated NF-{kappa}B activity in astrocytes. Black-Right-Pointing-Pointer (-)-Epicatechin did not regulate nuclear translocation of the NF-{kappa}B subunit, p65. -- Abstract: Neuroinflammation plays an important role in the progression of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Sustained activation of nuclear transcription factor {kappa}B (NF-{kappa}B) is thought to play an importantmore » role in the pathogenesis of neurodegenerative disorders. Flavonoids have been shown to possess antioxidant and anti-inflammatory properties and we investigated whether flavonoids, at submicromolar concentrations relevant to their bioavailability from the diet, were able to modulate NF-{kappa}B signalling in astrocytes. Using luciferase reporter assays, we found that tumour necrosis factor (TNF{alpha}, 150 ng/ml) increased NF-{kappa}B-mediated transcription in primary cultures of mouse cortical astrocytes, which was abolished on co-transfection of a dominant-negative I{kappa}B{alpha} construct. In addition, TNF{alpha} increased nuclear localisation of p65 as shown by immunocytochemistry. To investigate potential flavonoid modulation of NF-{kappa}B activity, astrocytes were treated with flavonoids from different classes; flavan-3-ols ((-)-epicatechin and (+)-catechin), flavones (luteolin and chrysin), a flavonol (kaempferol) or the flavanones (naringenin and hesperetin) at dietary-relevant concentrations (0.1-1 {mu}M) for 18 h. None of the flavonoids modulated constitutive or

  14. Transcription factor NF-kappaB participates in regulation of epithelial cell turnover in the colon.

    PubMed

    Inan, M S; Tolmacheva, V; Wang, Q S; Rosenberg, D W; Giardina, C

    2000-12-01

    The transcription factor nuclear factor (NF)-kappaB regulates the expression of genes that can influence cell proliferation and death. Here we analyze the contribution of NF-kappaB to the regulation of epithelial cell turnover in the colon. Immunohistochemical, immunoblot, and DNA binding analyses indicate that NF-kappaB complexes change as colonocytes mature: p65-p50 complexes predominate in proliferating epithelial cells of the colon, whereas the p50-p50 dimer is prevalent in mature epithelial cells. NF-kappaB1 (p50) knockout mice were used to study the role of NF-kappaB in regulating epithelial cell turnover. Knockout animals lacked detectable NF-kappaB DNA binding activity in isolated epithelial cells and had significantly longer crypts with a more extensive proliferative zone than their wild-type counterparts (as determined by proliferating cell nuclear antigen staining and in vivo bromodeoxyuridine labeling). Gene expression profiling reveals that the NF-kappaB1 knockout mice express the potentially growth-enhancing tumor necrosis factor (TNF)-alpha and nerve growth factor-alpha genes at elevated levels, with in situ hybridization localizing some of the TNF-alpha expression to epithelial cells. TNF-alpha is NF-kappaB regulated, and its upregulation in NF-kappaB1 knockouts may result from an alleviation of p50-p50 repression. NF-kappaB complexes may therefore influence cell proliferation in the colon through their ability to selectively activate and/or repress gene expression.

  15. 20 CFR 725.704 - Notification of right to medical benefits; authorization of treatment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Vocational Rehabilitation § 725.704 Notification of right to medical benefits; authorization of treatment. (a... is desirable or necessary in the best interest of the miner. The miner may change physicians or...

  16. 20 CFR 725.309 - Additional claims; effect of a prior denial of benefits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (child), and 725.222 (parent, brother, or sister)) has changed since the date upon which the order..., child, parent, brother, or sister shall be denied unless the applicable conditions of entitlement in...

  17. 20 CFR 725.309 - Additional claims; effect of a prior denial of benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (child), and 725.222 (parent, brother, or sister)) has changed since the date upon which the order..., child, parent, brother, or sister shall be denied unless the applicable conditions of entitlement in...

  18. 20 CFR 725.309 - Additional claims; effect of a prior denial of benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (child), and 725.222 (parent, brother, or sister)) has changed since the date upon which the order..., child, parent, brother, or sister shall be denied unless the applicable conditions of entitlement in...

  19. 20 CFR 725.309 - Additional claims; effect of a prior denial of benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (child), and 725.222 (parent, brother, or sister)) has changed since the date upon which the order..., child, parent, brother, or sister shall be denied unless the applicable conditions of entitlement in...

  20. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother... Benefits) § 725.222 Conditions of entitlement; parent, brother, or sister. (a) An individual is eligible for benefits as a surviving parent, brother or sister if all of the following requirements are met: (1...

  1. Immunoglobulin kappa light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement.

    PubMed Central

    Goodhardt, M; Babinet, C; Lutfalla, G; Kallenbach, S; Cavelier, P; Rougeon, F

    1989-01-01

    We have produced transgenic mice which synthesize chimeric mouse-rabbit immunoglobulin (Ig) kappa light chains following in vivo recombination of an injected unrearranged kappa gene. The exogenous gene construct contained a mouse germ-line kappa variable (V kappa) gene segment, the mouse germ-line joining (J kappa) locus including the enhancer, and the rabbit b9 constant (C kappa) region. A high level of V-J recombination of the kappa transgene was observed in spleen of the transgenic mice. Surprisingly, a particularly high degree of variability in the exact site of recombination and the presence of non germ-line encoded nucleotides (N-regions) were found at the V-J junction of the rearranged kappa transgene. Furthermore, unlike endogenous kappa genes, rearrangement of the exogenous gene occurred in T-cells of the transgenic mice. These results show that additional sequences, other than the heptamer-nonamer signal sequences and the promoter and enhancer elements, are required to obtain stage- and lineage- specific regulation of Ig kappa light chain gene rearrangement in vivo. Images PMID:2508061

  2. Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer.

    PubMed

    Lee, Byung Lan; Lee, Hye Seung; Jung, Jieun; Cho, Sung Jin; Chung, Hee-Yong; Kim, Woo Ho; Jin, Young-Woo; Kim, Chong Soon; Nam, Seon Young

    2005-04-01

    Because the biological significance of constitutive nuclear factor-kappaB (NF-kappaB) activation in human gastric cancer is unclear, we undertook this study to clarify the regulatory mechanism of NF-kappaB activation and its clinical significance. Immunohistochemistry for NF-kappaB/RelA was done on 290 human gastric carcinoma specimens placed on tissue array slides. The correlations between NF-kappaB activation and clinicopathologic features, prognosis, Akt activation, tumor suppressor gene expression, or Bcl-2 expression were analyzed. We also did luciferase reporter assay, Western blot analysis, and reverse transcription-PCR using the SNU-216 human gastric cancer cell line transduced with retroviral vectors containing constitutively active Akt or the NF-kappaB repressor mutant of IkappaBalpha. Nuclear expression of RelA was found in 18% of the gastric carcinomas and was higher in early-stage pathologic tumor-node-metastasis (P = 0.019). A negative correlation was observed between NF-kappaB activation and lymphatic invasion (P = 0.034) and a positive correlation between NF-kappaB activation and overall survival rate of gastric cancer patients (P = 0.0228). In addition, NF-kappaB activation was positively correlated with pAkt (P = 0.047), p16 (P = 0.004), adenomatous polyposis coli (P < 0.001), Smad4 (P = 0.002), and kangai 1 (P < 0.001) expression. An in vitro study showed that NF-kappaB activity in gastric cancer cells is controlled by and controls Akt. NF-kappaB activation was frequently observed in early-stage gastric carcinoma and was significantly correlated with better prognosis and Akt activation. These findings suggest that NF-kappaB activation is a valuable prognostic variable in gastric carcinoma.

  3. 40 CFR 725.305 - Persons who may apply under this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a result of the test marketing. A person may apply under this subpart for the following test... for Test Marketing § 725.305 Persons who may apply under this subpart. A person identified in this section may apply for a test marketing exemption. EPA may grant the exemption if the person demonstrates...

  4. 20 CFR 725.224 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; parent... Benefits) § 725.224 Determination of relationship; parent, brother, or sister. (a) An individual will be considered to be the parent, brother, or sister of a miner if the courts of the State in which the miner was...

  5. Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells.

    PubMed

    Voisard, R; Huber, N; Baur, R; Susa, M; Ickrath, O; Both, A; Koenig, W; Hombach, V

    2001-01-01

    Activation of nuclear factor-kappaB (NF-kappaB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-alpha (TNF-alpha) induced and NF-kappaB mediated expression of intercellular adhesion molecule-1 (ICAM-1) can be inhibited by antisense RelA p65 and NF-kappaB1 p50 oligonucleotides (RelA p65 and NF-kappaB1 p50). Smooth muscle cells (SMC) from human coronary plaque material (HCPSMC, plaque material of 52 patients), SMC from the human coronary media (HCMSMC), human endothelial cells (EC) from umbilical veins (HUVEC), and human coronary EC (HCAEC) were successfully isolated (HCPSMC, HUVEC), identified and cultured (HCPSMC, HCMSMC, HUVEC, HCAEC). 12 hrs prior to TNF-alpha stimulus (20 ng/mL, 6 hrs) RelA p65 and NF-kappaB1 p50 (1, 2, 4, 10, 20, and 30 microM) and controls were added for a period of 18 hrs. In HUVEC and HCAEC there was a dose dependent inhibition of ICAM-1 expression after adding of both RelA p65 and NF-kappaB1 p50. No inhibitory effect was seen after incubation of HCMSMC with RelA p65 and NF-kappaB1 p50. A moderate inhibition of ICAM-1 expression was found after simultaneous addition of RelA p65 and NF-kappaB1 p50 to HCPSMC, no inhibitory effect was detected after individual addition of RelA p65 and NF-kappaB1 p50. The data point out that differences exist in the NF-kappaB mediated expression of ICAM-1 between EC and SMC. Experimental antisense strategies directed against RelA p65 and NF-kappaB1 p50 in early atherosclerosis and restenosis are promising in HCAEC but will be confronted with redundant pathways in HCMSMC and HCPSMC.

  6. The radiant ephemerides of kappa-Cygnids from the IMO video database

    NASA Astrophysics Data System (ADS)

    Triglav-Cekada, Mihaela

    2006-08-01

    The analysis of single-station IMO video network data of the July and August period with 36 576 meteors in search of kappa-Cygnid, alpha-Lyrid and zeta-Draconid meteor showers was made using the program Radiant. These showers will be named kappa-Cygnid meteor complex radiants. The detailed analysis of the whole August period from 1993-2004 included the behavior of radiants in different magnitude ranges and different years from 2000 on. Detailed radiant calculations for different velocities for 5g and 10g solar longitude intervals were also done. In 10g solar longitude intervals also the calculations for different magnitude ranges were conducted. The activity of the kappa-Cygnid radiant and the alpha-Lyrid radiant was proven, unlike the zeta-Draconid radiant, where no activity could be confirmed. For the whole August period also the behavior of radiants in separate years 2000-2004, when day-to-day meteor coverage is available, was made. From that it can be hinted on alternating bigger activity of the kappa-Cygnid and alpha-Lyrid radiants. In the years 2000 and 2001 the alpha-Lyrid radiant is more active, when on the contrary in 2002, 2003 and 2004 the kappa-Cygnid radiant is more active. The year 2003 is interesting from another aspect, as three radiants can be seen. If the third radiant is the zeta-Draconid radiant, a few years more video observations will have to be gathered and the radiant calculations repeated. For the day of the kappa-Cygnid meteor complex maximum, on August 18, the mean radiant positions were deduced: the more active kappa-Cygnid radiant lies at alpha=280 deg and delta=+58 deg with an area of the maximum probability of 10 deg x 15 deg, and the less active alpha-Lyrid radiant is placed at alpha=292 deg and delta=+52 deg with a radius of maximum probability of 2 deg. The radiant drift was not possible to obtain as in the 5 deg and 10 deg solar longitude interval calculations the positions of both radiants apparently oscillate. As no change can

  7. Fast variations in the ultraviolet resonance lines of Alpha Camelopardalis (O9.5 Ia) - Evidence for blobs in the wind

    NASA Technical Reports Server (NTRS)

    Lamers, Henry J. G. L. M.; Snow, Theodore P.; De Jager, Cornelis; Langerwerf, A.

    1988-01-01

    The 72 IUE spectra of Alpha Cam and 19 IUE spectra of Kappa Cas, obtained during 72 hours of continuous IUE time in September 1978 were searched for variations in the profiles of the resonance lines of Si IV, C IV, and N V, and the results are discussed. The UV resonance lines in the spectra of Alpha Cam showed variations at the 2 percent level near -1800, -700, and +700 km/s. The first two variations can be explained by absorption components of outward-accelerated blobs or shells with an average acceleration of 1.5 cm/sq s. The characteristics of the blobs and shells are discussed, including the column densities and masses. No variations were found in the spectra of Kappa Cas.

  8. A new structural class of proteasome inhibitors that prevent NF-kappa B activation.

    PubMed

    Lum, R T; Kerwar, S S; Meyer, S M; Nelson, M G; Schow, S R; Shiffman, D; Wick, M M; Joly, A

    1998-05-01

    The multicatalytic proteinase or proteasome is a highly conserved cellular structure that is responsible for the ATP-dependent proteolysis of many proteins involved in important regulatory cellular processes. We have identified a novel class of inhibitors of the chymotrypsin-like proteolytic activity of the 20S proteasome that exhibit IC50 values ranging from 0.1 to 0.5 microgram/mL (0.1 to 1 microM). In cell proliferation assays, these compounds inhibit growth with an IC50 ranging from 5 to 10 micrograms/mL (10-20 microM). A representative member of this class of inhibitors was tested in other biological assays. CVT-634 (5-methoxy-1-indanone-3-acetyl-leu-D-leu-1-indanylamide) prevented lipopolysaccharide (LPS), tumor necrosis factor (TNF)-, and phorbol ester-induced activation of nuclear factor kappa B (NF-kappa B) in vitro by preventing signal-induced degradation of I kappa B-alpha. In these studies, the I kappa B-alpha that accumulated was hyperphosphorylated, indicating that CVT-634 did not inhibit I kappa B-alpha kinase, the enzyme responsible for signal-induced phosphorylation of I kappa B-alpha. In vivo studies indicated that CVT-634 prevented LPS-induced TNF synthesis in a murine macrophage cell line. In addition, in mice pretreated with CVT-634 at 25 and 50 mg/kg and subsequently treated with LPS, serum TNF levels were significantly lower (225 +/- 59 and 83 +/- 41 pg/mL, respectively) than in those mice that were treated only with LPS (865 +/- 282 pg/mL). These studies suggest that specific inhibition of the chymotrypsin-like activity of the proteasome is sufficient to prevent signal-induced NF-kappa B activation and that the proteasome is a novel target for the identification of agents that may be useful in the treatment of diseases whose etiology is dependent upon the activation of NF-kappa B.

  9. Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reimers, Kerstin; Buchholz, Katja; Werchau, Hermann

    2005-01-20

    Respiratory syncytial virus (RSV) induces the production of a number of cytokines and chemokines by activation of nuclear factor kappa B (NF-{kappa}B). The activation of NF-{kappa}B has been shown to depend on viral replication in the infected cells. In this study, we demonstrate that expression of RSV M2-1 protein, a transcriptional processivity and anti-termination factor, is sufficient to activate NF-{kappa}B in A549 cells. Electromobility shift assays show increased NF-{kappa}B complexes in the nuclei of M2-1-expressing cells. M2-1 protein is found in nuclei of M2-1-expressing cells and in RSV-infected cells. Co-immunoprecipitations of nuclear extracts of M2-1-expressing cells and of RSV-infected cellsmore » revealed an association of M2-1 with Rel A protein. Furthermore, the activation of NF-{kappa}B depends on the C-terminus of the RSV M2-1 protein, as shown by NF-{kappa}B-induced gene expression of a reporter gene construct.« less

  10. BFV activates the NF-kappaB pathway through its transactivator (BTas) to enhance viral transcription

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang Jian; Tan Juan; Zhang Xihui

    2010-05-10

    Multiple families of viruses have evolved sophisticated strategies to regulate nuclear factor-kappaB (NF-kappaB) signaling, which plays a pivotal role in diverse cellular events, including virus-host interactions. In this study, we report that bovine foamy virus (BFV) is able to activate the NF-kappaB pathway through the action of its transactivator, BTas. Both cellular IKKbeta and IkappaBalpha also participate in this activation. In addition, we demonstrate that BTas induces the processing of p100, which implies that BTas can activate NF-kappaB through a noncanonical pathway as well. Co-immunoprecipitation analysis shows that BTas interacts with IKK catalytic subunits (IKKalpha and IKKbeta), which may bemore » responsible for regulation of IKK kinase activity and persistent NF-kappaB activation. Furthermore, our results indicate that the level of BTas-mediated LTR transcription correlates with the activity of cellular NF-kappaB. Together, this study suggests that BFV activates the NF-kappaB pathway through BTas to enhance viral transcription.« less

  11. BFV activates the NF-kappaB pathway through its transactivator (BTas) to enhance viral transcription.

    PubMed

    Wang, Jian; Tan, Juan; Zhang, Xihui; Guo, Hongyan; Zhang, Qicheng; Guo, Tingting; Geng, Yunqi; Qiao, Wentao

    2010-05-10

    Multiple families of viruses have evolved sophisticated strategies to regulate nuclear factor-kappaB (NF-kappaB) signaling, which plays a pivotal role in diverse cellular events, including virus-host interactions. In this study, we report that bovine foamy virus (BFV) is able to activate the NF-kappaB pathway through the action of its transactivator, BTas. Both cellular IKKbeta and IkappaBalpha also participate in this activation. In addition, we demonstrate that BTas induces the processing of p100, which implies that BTas can activate NF-kappaB through a noncanonical pathway as well. Co-immunoprecipitation analysis shows that BTas interacts with IKK catalytic subunits (IKKalpha and IKKbeta), which may be responsible for regulation of IKK kinase activity and persistent NF-kappaB activation. Furthermore, our results indicate that the level of BTas-mediated LTR transcription correlates with the activity of cellular NF-kappaB. Together, this study suggests that BFV activates the NF-kappaB pathway through BTas to enhance viral transcription. Copyright 2010 Elsevier Inc. All rights reserved.

  12. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; parent, brother, or... Benefits) § 725.223 Duration of entitlement; parent, brother, or sister. (a) A parent, sister, or brother....222 are met. (b) The last month for which such parent is entitled to benefits is the month in which...

  13. 40 CFR 725.155 - Information to be included in the MCAN.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Information to be included in the MCAN... Activities Notification Requirements § 725.155 Information to be included in the MCAN. (a) Each person who is required by this part to submit a MCAN must include the information specified in paragraphs (c) through (h...

  14. 40 CFR 725.155 - Information to be included in the MCAN.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Information to be included in the MCAN... Activities Notification Requirements § 725.155 Information to be included in the MCAN. (a) Each person who is required by this part to submit a MCAN must include the information specified in paragraphs (c) through (h...

  15. 40 CFR 725.155 - Information to be included in the MCAN.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Information to be included in the MCAN... Activities Notification Requirements § 725.155 Information to be included in the MCAN. (a) Each person who is required by this part to submit a MCAN must include the information specified in paragraphs (c) through (h...

  16. 40 CFR 725.155 - Information to be included in the MCAN.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Information to be included in the MCAN... Activities Notification Requirements § 725.155 Information to be included in the MCAN. (a) Each person who is required by this part to submit a MCAN must include the information specified in paragraphs (c) through (h...

  17. The kappa-opiate receptor impacts the pathophysiology and behavior of substance use.

    PubMed

    Mysels, David; Sullivan, Maria A

    2009-01-01

    There is increasing evidence that the kappa-opiate receptor, in addition to the mu-opiate receptor, plays an important role in substance use pathophysiology and behavior. As dopamine activity is upregulated through chronic substance use, kappa receptor activity, mediated through the peptide dynorphin, is upregulated in parallel. Dynorphin causes dysphoria and decreased locomotion, and the upregulation of its activity on the kappa receptor likely dampens the excitation caused by increased dopaminergic activity. This feedback mechanism may have significant clinical implications for treating drug dependent patients in various stages of their pathology.

  18. Polycystin-1 promotes PKC{alpha}-mediated NF-{kappa}B activation in kidney cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Banzi, Manuela; Aguiari, Gianluca; Trimi, Viky

    2006-11-17

    Polycystin-1 (PC1), the PKD1 gene product, is a membrane receptor which regulates many cell functions, including cell proliferation and apoptosis, both typically increased in cyst lining cells in autosomal dominant polycystic kidney disease. Here we show that PC1 upregulates the NF-{kappa}B signalling pathway in kidney cells to prevent cell death. Human embryonic kidney cell lines (HEK293{sup CTT}), stably expressing a PC1 cytoplasmic terminal tail (CTT), presented increased NF-{kappa}B nuclear levels and NF-{kappa}B-mediated luciferase promoter activity. This, consistently, was reduced in HEK293 cells in which the endogenous PC1 was depleted by RNA interference. CTT-dependent NF-{kappa}B promoter activation was mediated by PKC{alpha}more » because it was blocked by its specific inhibitor Ro-320432. Furthermore, it was observed that apoptosis, which was increased in PC1-depleted cells, was reduced in HEK293{sup CTT} cells and in porcine kidney LtTA cells expressing a doxycycline-regulated CTT. Staurosporine, a PKC inhibitor, and parthenolide, a NF-{kappa}B inhibitor, significantly reduced the CTT-dependent antiapoptotic effect. These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKC{alpha}-mediated NF-{kappa}B signalling and cell survival.« less

  19. NF-{kappa}B inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhong Caiyun; Zhou Yamei; Pinkerton, Kent E.

    2008-07-15

    Apoptosis is a vital mechanism for the regulation of cell turnover and plays a critical role in tissue homeostasis and development of many disease processes. Previous studies have demonstrated the apoptotic effect of tobacco smoke; however, the molecular mechanisms by which tobacco smoke triggers apoptosis remain unclear. In the present study we investigated the effects of tobacco smoke on the induction of apoptosis in the lungs of rats and modulation of nuclear factor-kappa B (NF-{kappa}B) in this process. Exposure of rats to 80 mg/m{sup 3} tobacco smoke significantly induced apoptosis in the lungs. Tobacco smoke resulted in inhibition of NF-{kappa}Bmore » activity, noted by suppression of inhibitor of {kappa}B (I{kappa}B) kinase (IKK), accumulation of I{kappa}B{alpha}, decrease of NF-{kappa}B DNA binding activity, and downregulation of NF-{kappa}B-dependent anti-apoptotic proteins, including Bcl-2, Bcl-xl, and inhibitors of apoptosis. Initiator caspases for the death receptor pathway (caspase 8) and the mitochondrial pathway (caspase 9) as well as effector caspase 3 were activated following tobacco smoke exposure. Tobacco smoke exposure did not alter the levels of p53 and Bax proteins. These findings suggest the role of NF-{kappa}B pathway in tobacco smoke-induced apoptosis.« less

  20. Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells.

    PubMed Central

    Feddersen, R M; Van Ness, B G

    1990-01-01

    Previous characterization of mouse immunoglobulin kappa gene rearrangement products cloned from murine plasmacytomas has indicated that two recombination events can take place on a single kappa allele (R. M. Feddersen and B. G. Van Ness, Proc. Natl. Acad. Sci. USA 82:4792-4797, 1985; M. A. Shapiro and M. Weigert, J. Immunol. 139:3834-3839, 1987). To determine whether multiple recombinations on a single kappa allele can contribute to the formation of productive V-J genes through corrective recombinations, we have examined several Abelson murine leukemia virus-transformed pre-B-cell clones which rearrange the kappa locus during cell culture. Clonal cell lines which had rearranged one kappa allele nonproductively while maintaining the other allele in the germ line configuration were grown, and secondary subclones, which subsequently expressed kappa protein, were isolated and examined for further kappa rearrangement. A full spectrum of rearrangement patterns was observed in this sequential cloning, including productive and nonproductive recombinations of the germ line allele and secondary recombinations of the nonproductive allele. The results show that corrective V-J recombinations, with displacement of the nonproductive kappa gene, occur with a significant frequency (6 of 17 kappa-producing subclones). Both deletion and maintenance of the primary (nonfunctional) V-J join, as a reciprocal product, were observed. Images PMID:2153918

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