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Sample records for kasvava inimmju surve

  1. The EBR-II materials-surveillance program. 4: Results of SURV-4 and SURV-6

    SciTech Connect

    Ruther, W.E.; Hayner, G.O.; Carlson, B.G.; Ebersole, E.R.; Allen, T.R.

    1998-01-01

    In March of 1965, a set of surveillance (SURV) samples was placed in the EBR-II reactor to determine the effect of irradiation, thermal aging, and sodium corrosion on reactor materials. Eight subassemblies were placed into row 12 positions of EBR-II to determine the effect of irradiation at 370 C. Two subassemblies were placed into the primary sodium basket to determine the effect of thermal aging at 370 C. For both the irradiated and thermally aged samples, one half of all samples were exposed to primary system sodium while one half were sealed in capsules with a helium atmosphere. Fifteen different structural materials were tested in the SURV program. In addition to the fifteen types of metal samples, graphite blocks were irradiated in the SURV subassemblies to determine the effect of irradiation on the graphite neutron shield. In this report, the properties of these materials irradiated at 370 C to a total fluence of 2.2 x 10{sup 22} n/cm{sup 2} (over 2,994 days) are compared with those of similar specimens thermally aged at 370 C for 2,994 days in the storage basket of the reactor. The properties analyzed were weight, density, microstructure, hardness, tensile and yield strength, impact strength, and creep.

  2. The Snapshot A-Star SurveY (SASSY)

    NASA Astrophysics Data System (ADS)

    Garani, Jasmine; Nielsen, Eric L.; Marchis, Franck; Liu, Michael C.; Macintosh, Bruce; Rajan, Abhijith; De Rosa, Robert J.; Wang, Jason; Esposito, Thomas; Best, William M. J.; Bowler, Brendan P.; Dupuy, Trent J.; Ruffio, Jean-Baptise

    2017-01-01

    We present the Snapshot A-Star SurveY (SASSY), an adaptive optics survey conducted using NIRC2 on the Keck II telescope to search for young, self-luminious planets and brown dwarfs (M > 5MJup) around high mass stars (M > 1.5 M⊙). We describe a custom data-reduction pipeline developed for the coronagraphic observations of our 200 target stars. Our data analysis method includes basic near infrared data processing (flat-field correction, bad pixel removal, distortion correction) as well as performing PSF subtraction through a Reference Differential Imaging algorithm based on a library of PSFs derived from the observations using the pyKLIP routine. We present early results from the survey including planet and brown dwarf candidates and the status of ongoing follow-up observations. Utilizing the high contrast of Keck NIRC2 coronagraphic observations, SASSY reaches sensitivity to brown dwarfs and planetary mass companions at separations between 0.6'' and 4''. With over 200 stars observed we are tripling the number of high-mass stars imaged at these contrasts and sensitivities compared to previous surveys. This work was supported by the NSF REU program at the SETI Institute and NASA grant NNX14AJ80G.

  3. SurvExpress: an online biomarker validation tool and database for cancer gene expression data using survival analysis.

    PubMed

    Aguirre-Gamboa, Raul; Gomez-Rueda, Hugo; Martínez-Ledesma, Emmanuel; Martínez-Torteya, Antonio; Chacolla-Huaringa, Rafael; Rodriguez-Barrientos, Alberto; Tamez-Peña, José G; Treviño, Victor

    2013-01-01

    Validation of multi-gene biomarkers for clinical outcomes is one of the most important issues for cancer prognosis. An important source of information for virtual validation is the high number of available cancer datasets. Nevertheless, assessing the prognostic performance of a gene expression signature along datasets is a difficult task for Biologists and Physicians and also time-consuming for Statisticians and Bioinformaticians. Therefore, to facilitate performance comparisons and validations of survival biomarkers for cancer outcomes, we developed SurvExpress, a cancer-wide gene expression database with clinical outcomes and a web-based tool that provides survival analysis and risk assessment of cancer datasets. The main input of SurvExpress is only the biomarker gene list. We generated a cancer database collecting more than 20,000 samples and 130 datasets with censored clinical information covering tumors over 20 tissues. We implemented a web interface to perform biomarker validation and comparisons in this database, where a multivariate survival analysis can be accomplished in about one minute. We show the utility and simplicity of SurvExpress in two biomarker applications for breast and lung cancer. Compared to other tools, SurvExpress is the largest, most versatile, and quickest free tool available. SurvExpress web can be accessed in http://bioinformatica.mty.itesm.mx/SurvExpress (a tutorial is included). The website was implemented in JSP, JavaScript, MySQL, and R.

  4. SurvNet: a web server for identifying network-based biomarkers that most correlate with patient survival data.

    PubMed

    Li, Jun; Roebuck, Paul; Grünewald, Stefan; Liang, Han

    2012-07-01

    An important task in biomedical research is identifying biomarkers that correlate with patient clinical data, and these biomarkers then provide a critical foundation for the diagnosis and treatment of disease. Conventionally, such an analysis is based on individual genes, but the results are often noisy and difficult to interpret. Using a biological network as the searching platform, network-based biomarkers are expected to be more robust and provide deep insights into the molecular mechanisms of disease. We have developed a novel bioinformatics web server for identifying network-based biomarkers that most correlate with patient survival data, SurvNet. The web server takes three input files: one biological network file, representing a gene regulatory or protein interaction network; one molecular profiling file, containing any type of gene- or protein-centred high-throughput biological data (e.g. microarray expression data or DNA methylation data); and one patient survival data file (e.g. patients' progression-free survival data). Given user-defined parameters, SurvNet will automatically search for subnetworks that most correlate with the observed patient survival data. As the output, SurvNet will generate a list of network biomarkers and display them through a user-friendly interface. SurvNet can be accessed at http://bioinformatics.mdanderson.org/main/SurvNet.

  5. MetaSurv: Web-Platform Generator for the Monitoring of Health Indicators and Interactive Geographical Information System.

    PubMed

    Toubiana, Laurent; Moreau, Stéphane; Bonnard, Gaétan

    2005-01-01

    The control of the transmissible epidemics of diseases requires fast and effective tools for data acquisition, analysis, and information feedback to the actors of health like to general public. We present a tool for the fast creation of platforms of monitoring on Internet allowing the collection and the analysis in real time of the epidemic data of any origin with the dynamic and interactive cartographic representation. A Web-based Geographic Information System (Web-GIS) has been designed for communicable diseases monitoring. The Web-GIS was coupled to a data warehouse and embedded in an n-tier architecture designed as the Multi-Source Information System. It allows to access views of communicable diseases. Thus it is a useful tool for supporting health care decision-making for communicable diseases.This tool is based on the 20 years experiment of the Network Sentinels, with the daily participation of the general practitioners.

  6. The bathymetric distribution of intertidal eelgrass Zostera marina L. in three coastal estuaries of Oregon

    EPA Science Inventory

    Distributions of native eelgrass Zostera marina L. within the intertidal and shallow subtidal zones of three Oregon coastal estuaries (Tillamook, Yaquina, and Alsea) were determined by digital classification of aerial color infrared (CIR) orthophotographs. Stratified random surv...

  7. DISTRIBUTION OF SELECTED INVASIVE PLANTS IN RIPARIAN ECOSYSTEMS OF THE WESTERN UNITED STATES

    EPA Science Inventory

    Riparian ecosystems typically exhibit high levels of plant species richness, physical disturbance, and interconnectedness; characteristics that may favor establishment and spread of invasive plant species. To assess the magnitude of this invasion, we organized an extensive surve...

  8. Assessing patterns of fish demographics and habitat in stream networks

    EPA Science Inventory

    Effective habitat restoration planning requires correctly anticipating demographic responses to altered habitats. New applications of Passive Integrated Transponder (PIT) tag technology to fish-habitat research have provided critical insights into fish movement, growth, and surv...

  9. Application of restoration scenarios to basin-scale demographics of coho salmon inferred from pit-tags

    EPA Science Inventory

    Effective habitat restoration planning requires correctly anticipating demographic responses to altered habitats. New applications of Passive Integrated Transponder (PIT) tag technology to fish-habitat research have provided critical insights into fish movement, growth, and surv...

  10. MAMMARY GLAND DEVELOPMENT AS A SENSITIVE END-POINT FOLLOWING ACUTE PERNATAL EXPOSURE TO A LOW DOSE ATRAZINE METABOLITE MIXTURE IN FEMALE LONG EVANS RATS

    EPA Science Inventory

    In order to characterize the potential developmental effects of atrazine (ATR) metabolites at low doses, an environmentally-based mixture (EBM) of ATR and its metabolites hydroxyatrazine, diaminochlorotriazine, deethylatrazine, and deisopropylatrazine was formulated based on surv...

  11. Web-based Surveillance and Global Salmonella Distribution, 2000–2002

    PubMed Central

    Wong, Danilo M.A. Lo Fo; Patrick, Mary E.; Binsztein, Norma; Cieslik, Anna; Chalermchaikit, Thongchai; Aidara-Kane, Awa; Ellis, Andrea; Angulo, Frederick J.; Wegener, Henrik C.

    2006-01-01

    Salmonellae are a common cause of foodborne disease worldwide. The World Health Organization (WHO) supports international foodborne disease surveillance through WHO Global Salm-Surv and other activities. WHO Global Salm-Surv members annually report the 15 most frequently isolated Salmonella serotypes to a Web-based country databank. We describe the global distribution of reported Salmonella serotypes from human and nonhuman sources from 2000 to 2002. Among human isolates, S. Enteritidis was the most common serotype, accounting for 65% of all isolates. Among nonhuman isolates, although no serotype predominated, Salmonella enterica serovar Typhimurium was reported most frequently. Several serotypes were reported from only 1 region of the world. The WHO Global Salm-Surv country databank is a valuable public health resource; it is a publicly accessible, Web-based tool that can be used by health professionals to explore hypotheses related to the sources and distribution of salmonellae worldwide. PMID:16704773

  12. Depressed Exercise Peak Ejection Rate Detected on Ambulatory Radionuclide Monitoring Reflects End-Stage Cardiac Inotropic Reserve and Predicts Mortality in Ischaemic Cardiomyopathy

    PubMed Central

    Carboni, Gian Piero

    2012-01-01

    Background Fifteen patients with ischaemic cardiomyopathy and inducible ischaemia were studied to determine the mechanisms of mortality. Failure of the contractile reserve during daily life activities may reflect a prognostic index. Methods Single photon emission cardiac tomography and radionuclide ambulatory monitoring (Vest) data were analysed in all patients with a 7-year follow-up. Results At peak exercise on Vest, the 7 non-survivors (N-SURV) showed worse peak ejection rates (PERs) and ejection fractions (EFs) compared with the 8 survivors (SURV), (2 ± 0.6 vs. 3.3 ± 0.7; end-diastolic volumes (EDVs), P < 0.003), and (34 ± 10% vs. 50 ± 13%; P < 0.02), respectively. However, exercise peak filling rates (PFRs) (1.9 ± 0.6 vs. 2.7 ± 0.9; EDVs/s) and exercise heart rates (HRs), (97 ± 17 vs. 106 ± 10), did not differ between the two groups (P > 0.05). In SURV, exercise PERs, which represented rapid left ventricular (LV) emptying, were significantly correlated with exercise PFRs, representing rapid LV filling, (r = 0.71, P < 0.04) but not in N-SURV (r = 0.66, P > 0.05). Among SURV, the Frank-Starling mechanism was thus preserved but not in N-SURV. Upon Cox analysis, overall LV function parameters, exercise PER was the only predictive measure associated with mortality (b = - 0.018, relative hazard ratio = 0.98, P = 0.02). Conclusions Exercise PER reduced values reflected failure of the Frank-Starling mechanism, the incapacity of the heart to perform rapid contractile adaptations to daily life activities and a poor prognosis.

  13. Hydrological Parameter Estimations from a Conservative Tracer Test With Variable-Density Effects at the Boise Hydrogeophysical Research Site

    DTIC Science & Technology

    2011-12-15

    MODFLOW [Harbaugh et al., 2000], MT3DMS [Zheng and Wang, 1999; Zheng, 2005], and SEAWAT [e.g., Guo and Langevin, 2002; Langevin et al., 2003, 2007...which are fully public- domain codes for 3-D flow and variable-density transport modeling. SEAWAT combines a modified version of MODFLOW and MT3DMS...Surv., Reston, Va. Harbaugh, A. W., E. R. Banta, M. C. Hill, and M. G. McDonald (2000), MODFLOW -2000, The U.S. Geological Surv. modular ground-water

  14. National Aquatic Resource Surveys: Multiple objectives and constraints lead to design complexity

    EPA Science Inventory

    The US Environmental Protection Agency began conducting the National Aquatic resource Surveys (NARS) in 2007 with a national survey of lakes (NLA 2007) followed by rivers and streams in 2008-9 (NRSA 2008), coastal waters in 2010 (NCCA 2010) and wetlands in 2011 (NWCA). The surve...

  15. Expatriate Parents and Supplementary Education in Japan: Survival Strategy or Acculturation Strategy

    ERIC Educational Resources Information Center

    Cook, Melodie

    2013-01-01

    The increase in the use of supplementary education, or "juku," in Japan by Japanese families in order to augment their children's chances of success in entering prestigious pre-tertiary and tertiary institutions is documented (Blumenthal in "Asian Surv" 32(5):448-460, 1992; Bray and Lykins in "Shadow education; private…

  16. THE ABRF-MARG MICROARRAY SURVEY 2004: TAKING THE PULSE OF THE MICROARRAY FIELD

    EPA Science Inventory

    Over the past several years, the field of microarrays has grown and evolved drastically. In its continued efforts to track this evolution, the ABRF-MARG has once again conducted a survey of international microarray facilities and individual microarray users. The goal of the surve...

  17. Theory of planned behavior and multivitamin supplement use in Caucasian college females

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this study was to identify predictors of the use of multivitamin supplements among Caucasian college females utilizing the Theory of Planned Behavior. Variables of the Theory of Planned Behavior and the self-reported use of multivitamin supplements were measured by two separate surv...

  18. AN ASSESSMENT OF THE ECOLOGICAL CONDITION OF PENSACOLA BAY, FLORIDA

    EPA Science Inventory

    Assessment of the Ecological Condition of Pensacola Bay, Florida (Abstract). To be presented at the16th Biennial Conference of the Estuarine Research Foundation, ERF 2001: An Estuarine Odyssey, 4-8 November 2001, St. Pete Beach, FL. 1 p. (ERL,GB R848).

    We conducted surve...

  19. ENDANGERED AQUATIC VERTEBRATES: COMPARATIVE AND PROBABILISTIC-BASED TOXICOLOGY

    EPA Science Inventory

    It has previously been assumed that endangered, threatened, and candidate endangered species (collectively known as “listed” species) are uniquely sensitive to chemicals. The purpose of this cooperative research effort (U.S. Environmental Protection Agency, U.S. Geological Surve...

  20. SURVEILLANCE FOR WATERBORNE-DISEASE OUTBREAKS - UNITED STATES, 1999-2000

    EPA Science Inventory

    PROBLEM/CONDITION: Since 1971, CDC, the U.S. Environmental Protection Agency (EPA), and the Council of State and Territorial Epidemiologists (CSTE) have maintained a collaborative surveillance system for the occurrences and causes of waterborne-disease outbreaks (WBDOs).This surv...

  1. Loss of microbial (pathogen) infections associated with recent invasions of the red imported fire ant Solenopsis invicta

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Loss of natural enemies during colonization is a prominent hypothesis explaining enhanced performance of invasive species in introduced areas. Numerous studies have tested this enemy release hypothesis in a wide range of taxa but few studies have focused on invasive ants. We conducted extensive surv...

  2. Old moms with new tricks: modeling the effects of age-specific spawning behaviors in Pacific Ocean perch

    EPA Science Inventory

    In commercially exploited, long-lived fish species, age structure plays an important role in determining population stability and resilience to human and environmental impacts. The often observed increase in energy allocation per offspring by older females can improve larval surv...

  3. Wheat landraces: A mini review

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Farmers developed and utilized diverse wheat landraces to meet the complexity of a multitude of spatio-temporal, agro-ecological systems and to provide reliable sustenance and a sustainable food source to local communities. The genetic structure of wheat landraces is an evolutionary approach to surv...

  4. Classifying Exercise Activities According to Motivation, Self-Objectification, and Disordered Eating: How Can We Target Change?

    ERIC Educational Resources Information Center

    Grupski, Allison

    2009-01-01

    SurvObjectification theorists suggest that one way for women to combat self-objectification is through participation in sport and exercise activities that encourage body competence. This two-part study investigates the impact of (a) motivation for physical activity and (b) type of physical activity on the outcomes of self-objectification, body…

  5. Long-term snow distribution observations in a mountain catchment: assessing variability, time stability, and the representativeness of an index site

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study presents an analysis of snow distribution heterogeneity and the factors affecting this variability. The analysis focuses on manually-sampled data from 21 snow surveys covering 11 years at the drift-dominated Reynolds Mountain East catchment (0.36 km2) in southwestern Idaho, U.S.A. Surve...

  6. Resistance of Benghal Dayflower (Commelina benghalensis) Seeds to Harsh Environments and the Implications for Dispersal by Mourning Doves (Zenaida macroura) in Georgia, U.S.A.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The potential dispersal of Benghal dayflower seeds by mourning doves was studied in southern Georgia, U.S.A. The gut contents (both crop and gizzard) of mourning doves harvested in the autumn months were investigated to determine if mourning doves fed on Benghal dayflower and whether seeds can surv...

  7. Verde plant bug associatioin with boll damage including cotton boll rot and potential in-season indicators of damage

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cotton along the Gulf Coast of south Texas has experienced loss from cotton boll rot especially during the last 10 to 15 years, and stink bugs and plant bugs (Hemiptera: Pentatomidae and Miridae) that feed on cotton bolls have been suspected in introducing the disease. A replicated grower field surv...

  8. Association of Verde plant bug, Creontiades signatus (Hemiptera: Miridae), with cotton boll rot

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cotton along the Gulf Coast of south Texas has experienced loss from cotton boll rot especially during the last 10 to 15 years, and stink bugs and plant bugs (Hemiptera: Pentatomidae and Miridae) that feed on cotton bolls have been suspected in introducing the disease. A replicated grower field surv...

  9. HL7 Middleware Framework for Laboratory Notifications for Notifiable Diseases.

    PubMed

    Adnan, Mehnaz; Peterkin, Donald; McLaughlin, Aaron; Hill, Nicholas

    2015-01-01

    LabSurv is an electronic notification system developed to support laboratories to directly notify the results of notifiable disease testing to public health services in New Zealand. A direct laboratory notification middleware framework was developed to manage the information flow between laboratories and public health services. The framework uses an HL7 messaging standard to receive the laboratory results and windows services to integrate the results with the cases of notifiable diseases within a national electronic surveillance system. This paper presents the system design and implementation details of direct laboratory notification system in LabSurv. It presents the HL7 messages structure implemented in the system. Finally, the performance of the system based on implemented framework is analysed and presented to evaluate the efficiency of our design.

  10. Taxonomic Changes, Revised Occurrence Records and Notes on the Culicidae of Thailand and Neighboring Countries

    DTIC Science & Technology

    1990-12-01

    previously has not been recorded from Thailand, Gass ct al. (1982, 1983) reported this species to be the dominant Mansonia species in their study site in...On a collection ofanopheline and culicine mosquitoes from Siam. Rec. Malaria Surv. India 2:269-285. Bhat, H.R. 1975a. A survey of haematophagous arthro ...ecological notes. Indian J. Med. Res. 63:1583-1608. Bhat, H.R. 1975h. A survey of haematophagous arthro - pods in Western Himalayas, Sikkim and Hill

  11. Preclinical development of HIvax: Human survivin highly immunogenic vaccines.

    PubMed

    Hoffmann, Peter R; Panigada, Maddalena; Soprana, Elisa; Terry, Frances; Bandar, Ivo Sah; Napolitano, Andrea; Rose, Aaron H; Hoffmann, Fukun W; Ndhlovu, Lishomwa C; Belcaid, Mahdi; Moise, Lenny; De Groot, Anne S; Carbone, Michele; Gaudino, Giovanni; Matsui, Takashi; Siccardi, Antonio; Bertino, Pietro

    2015-01-01

    Our previous work involved the development of a recombinant fowlpox virus encoding survivin (FP-surv) vaccine that was evaluated for efficacy in mesothelioma mouse models. Results showed that FP-surv vaccination generated significant immune responses, which led to delayed tumor growth and improved animal survival. We have extended those previous findings in the current study, which involves the pre-clinical development of an optimized version of FP-surv designed for human immunization (HIvax). Survivin-derived peptides for the most common haplotypes in the human population were identified and their immunogenicity confirmed in co-culture experiments using dendritic cells and T cells isolated from healthy donors. Peptides confirmed to induce CD8(+) and CD4(+) T cells activation in humans were then included in 2 transgenes optimized for presentation of processed peptides on MHC-I (HIvax1) and MHC-II (HIvax2). Fowlpox vectors expressing the HIvax transgenes were then generated and their efficacy was evaluated with subsequent co-culture experiments to measure interferon-γ and granzyme B secretion. In these experiments, both antigen specific CD4(+) and CD8(+) T cells were activated by HIvax vaccines with resultant cytotoxic activity against survivin-overexpressing mesothelioma cancer cells. These results provide a rationale for clinical testing of HIvax1 and HIvax2 vaccines in patients with survivin-expressing cancers.

  12. Human survivin and Trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo.

    PubMed

    Aguilar-Guzmán, Lorena; Lobos-González, Lorena; Rosas, Carlos; Vallejos, Gerardo; Falcón, Cristián; Sosoniuk, Eduardo; Coddou, Francisca; Leyton, Lisette; Lemus, David; Quest, Andrew F G; Ferreira, Arturo

    2014-01-01

    Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth by interfering with blood supply. Tumor Associated Antigens are often employed to target tumors with therapeutic drugs, but some are also essential for tumor viability. Survivin (Surv) is a member of the inhibitor of apoptosis protein family that is considered a Tumor Associated Antigen important for cancer cell viability and proliferation. On the other hand, Trypanosoma cruzi (the agent of Chagas' disease) calreticulin (TcCRT) displays remarkable anti-angiogenic properties. Because these molecules are associated with different tumor targets, we reasoned that immunization with a Surv-encoding plasmid (pSurv) and concomitant TcCRT administration should generate a stronger anti-tumor response than application of either treatment separately. To evaluate this possibility, C57BL/6 mice were immunized with pSurv and challenged with an isogenic melanoma cell line that had been pre-incubated with recombinant TcCRT (rTcCRT). Following tumor cell inoculation, mice were injected with additional doses of rTcCRT. For the combined regimen we observed in mice that: i). Tumor growth was impaired, ii). Humoral anti-rTcCRT immunity was induced and, iii). In vitro rTcCRT bound to melanocytes, thereby promoting the incorporation of human C1q and subsequent macrophage phagocytosis of tumor cells. These observations are interpreted to reflect the consequence of the following sequence of events: rTcCRT anti-angiogenic activity leads to stress in tumor cells. Murine CRT is then translocated to the external membrane where, together with rTcCRT, complement C1 is captured, thus promoting tumor phagocytosis. Presentation of the Tumor Associated Antigen Surv induces the adaptive anti-tumor immunity and, independently, mediates anti-endothelial cell immunity leading to an

  13. Optimizing Vacuum Assisted Resin Transfer Moulding (VARTM) Processing Parameters to Improve Part Quality

    NASA Astrophysics Data System (ADS)

    Polowick, Christopher

    The Low Cost Composites (LCC) group at Carleton University is studying out-of-autoclave composite manufacturing processes such as Vacuum Assisted Resin Transfer Moulding (VARTM) and Closed Cavity Bag Moulding (CCBM). These processes are used to produce inexpensive and high performance components for the GeoSurv II, an Unmanned Aerial Vehicle (UAV) being developed at Carleton University. This research has focused on optimizing VARTM processing parameters to reduce the weight and improve the strength and surface finish of GeoSurv II composite components. A simulation was developed to model resin flow through in VARTM infusions and was used to simulate mould filling and resin emptying of the GeoSurv II inverted V-empennage and mission avionics hatch. The resin infusion schemes of these parts were designed to ensure full preform resin saturation, and minimize thickness variations. An experimental study of the effects of the presence of a corner on composite thickness, void content, and strength was conducted. It was found that inside corners result in local increases in thickness and void content due to poor preform compaction. A novel bagging technique was developed to improve corner compaction, and this technique was shown to reduce thickness variability and void content. The strength, void content, and thickness variation were found to be heavily dependent on corner radius, with corner radii greater than 6.4 mm displaying the greatest improvement in performance for the layups considered. The design of the empennage and hatch mould incorporated the results of this study to improve the quality of these components.

  14. One-Carbon Metabolism and Breast Cancer Survival in a Population-Based Study

    DTIC Science & Technology

    2005-06-01

    1. All genotype distributions at these three loci were in agreement with Hardy-Weinberg Equilibrium. In addition, genotyping for the MTHFR 677C>T...95%CI 1.04-2.06). MTHFR 677 C-- > T GENOTYPF AND BC SURV’,[VAL HR: 1.46 (1.04 -- 2.06) MTHFR 677 C->T Genotype------ TT or CT CC Overall survival ofthe...BC cases in the LIBCSP affected by MTHFR 677 C-.T genotypes: CC versus TT or CT c. Study associations of one-carbon metabolism (diet and polymorphism

  15. Cost Data Analysis Methodology for Defense Nuclear Agency Life Cycle Cost Programs. Volume 2

    DTIC Science & Technology

    1984-07-01

    8217., " 17, r" d7* ~f7. - pp.~A( irrdAC- Figue 3:The eneal RD S-urv Accrdig t Wiure 3the general c & -urve b ecie ytl following equations: ’Y=-0.0124...of return on private investment before corporate taxes and after adjusting for 19 ’S’ S.5 i "- "S - -i - ’ .i . .i - - , . . ’ - , - - - inflation...expected vylue of each cash amount and its associated uncertainty, or risk . The essential characteristics of the risk adjusted present value equation are

  16. Validation of an Active Multimedia Courseware Package for the Integrated Damage Control Training Technology (IDCTT) Trainer

    DTIC Science & Technology

    1994-09-01

    versa. Yet others feel that effort or feelings of frustration are the most important factors in workload; and so on. The results of previous studies ...the te-.i and e~ aluatuoi results of the Integrated Damage Control Training Te.- it ilog ý I DX1’T Traine r This, dce ice - - the pn’dut. of a four ye...The tiev% trainer \\X&s iom~prehCiiSi1.eI\\ esaluated using performance data and surve’N results collected from~ -students and iiistnkor’s dunnte a

  17. Ready Reserve Civilian Skills Utilization Study (RESCON).

    DTIC Science & Technology

    1975-11-10

    MOM~ A PAG.C, L.AW "O LAWV02 DA-A ASWtI E STArI.TU.AL DAMA SF𔄀LJAL :%V(L RI󈧰TS S(44RT r s wAS PtwbCLO ANLP keLe5 A LAW VTb6. 70 T0 PiLE O~CAT4OY...Economists 32 Historians 33 Political Scientists 34 Sociologists 35 Intelligence Analysists 39 Law Students 40 Lawyers 41 Law Enforcement 42 Civil...SURVE Y OR ANALYSIS2 Tito ianagement Engineering Brancal, AdMistrative Division continually performs management surveys or analyses for requesting

  18. Design definition study of a lift/cruise fan technology V/STOL aircraft. Volume 1: Navy operational aircraft

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Aircraft were designed and sized to meet Navy mission requirements. Five missions were established for evaluation: anti-submarine warfare (ASW), surface attack (SA), combat search and rescue (CSAR), surveillance (SURV), and vertical on-board delivery (VOD). All missions were performed with a short takeoff and a vertical landing. The aircraft were defined using existing J97-GE gas generators or reasonable growth derivatives in conjunction with turbotip fans reflecting LF460 type technology. The multipurpose aircraft configuration established for U.S. Navy missions utilizes the turbotip driven lift/cruise fan concept for V/STOL aircraft.

  19. Threatened Vertebrate Species Occurring or Believed to Occur in the Floodplains of the Mississippi River between Cairo, Illinois, and Minneapolis, Minnesota, and of the Illinois Waterway between Grafton, Illinois, and Chicago, Illinois,

    DTIC Science & Technology

    1975-01-01

    preliminary annotated list of the lampreys and fishes of Illinois. Illinois Nat. Rist. Surv. Biol. Notes No. 54. l2pp. " Smith, P. W. 1966a. Hyla avivoca ...Hybopsis x-punctata 17, 111 Lots iota 26, 113 Hyla avivoca avivoca 37, 116 Lutra canadensis 93, 94, 125 Hyla cinerea 37, 38, 116 Lynx rufus 94, 125...objects on the ground (Smith 1961:112). WESTERN BIRD-VOICED TREEFROG Hiyla avivoca avivoca Viosca (I11.-Rare) The western bird-voiced treefrog occurs

  20. Losses to Workers Displaced by Plant Closure or Layoff: A Survey of the Literature,

    DTIC Science & Technology

    1976-11-01

    AO-AU 137 PULIC RESEARCH INST ALEXANDRIA VA F/6 5/9 LOSSES 0 WOKERS DISPL CED BY PLANT CLOSURE OR LAYOFF : A SURVE_-ETC CU) NCOV 76 A NOLEN DL-75-8...NCLASSIFIED CRC-313 NL C RC 313LE E LOSSES TO WORKERS DISPLACED BY PLANT CLOSURE OR LAYOFF : A SURVEY OF THE LITERATURE La 1401 Wilson Boulevard <C...effects of job loss, in which control groups are ti.-;Ck to estimate losses in earnings over a number of years after layoff . Methods of analysis range

  1. Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection

    PubMed Central

    Li, Zhi; Yamada, Sohsuke; Wu, Ying; Wang, Ke-Yong; Liu, Yun-Peng; Uramoto, Hidetaka; Kohno, Kimitoshi; Sasaguri, Yasuyuki

    2016-01-01

    Background Polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) are important glycosyltransferases in cancer, but the clinical role of its individual isoforms is unclear. We investigated the clinical significance and survival relevance of one isoform, GalNAc-T6 in lung adenocarcinoma after curative resection. Results GalNAc-T6 was identified in 27.8% (55/198) of patients, and statistically indicated advanced TNM stage (P = 0.069). Multivariate analysis showed GalNAc-T6 to be an independent predictor for reduced overall survival of patients (P = 0.027), and the result was confirmed with bootstraping techniques, and on line “Kaplan-Meier Plotter” and “SurvExpress” database analysis, respectively. Moreover, ROC curve demonstrated that GalNAc-T6 expression significantly improved the accuracy of survival prediction. Methods With 198 paraffin-embedded tumor samples from lung adenocarcinoma patients, GalNAc-T6 expression was immunohistochemically assessed for the association with clinicopathological parameters. The prognostic significance was evaluated by Cox proportional hazards regression analysis with 1000 bootstraping. “Kaplan-Meier Plotter”, “SurvExpress” database analysis, and receiver-operating characteristic (ROC) curve were performed to provide further validation. Conclusions GalNAc-T6 expression correlated significantly with advanced TNM stage, and independently predicted worse OS for lung adenocarcinoma. PMID:27276675

  2. Translation, cross-cultural adaptation and validation of the Diabetes Empowerment Scale – Short Form

    PubMed Central

    Chaves, Fernanda Figueredo; Reis, Ilka Afonso; Pagano, Adriana Silvina; Torres, Heloísa de Carvalho

    2017-01-01

    ABSTRACT OBJECTIVE To translate, cross-culturally adapt and validate the Diabetes Empowerment Scale – Short Form for assessment of psychosocial self-efficacy in diabetes care within the Brazilian cultural context. METHODS Assessment of the instrument’s conceptual equivalence, as well as its translation and cross-cultural adaptation were performed following international standards. The Expert Committee’s assessment of the translated version was conducted through a web questionnaire developed and applied via the web tool e-Surv. The cross-culturally adapted version was used for the pre-test, which was carried out via phone call in a group of eleven health care service users diagnosed with type 2 diabetes mellitus. The pre-test results were examined by a group of experts, composed by health care consultants, applied linguists and statisticians, aiming at an adequate version of the instrument, which was subsequently used for test and retest in a sample of 100 users diagnosed with type 2 diabetes mellitus via phone call, their answers being recorded by the web tool e-Surv. Internal consistency and reproducibility of analysis were carried out within the statistical programming environment R. RESULTS Face and content validity were attained and the Brazilian Portuguese version, entitled Escala de Autoeficácia em Diabetes – Versão Curta, was established. The scale had acceptable internal consistency with Cronbach’s alpha of 0.634 (95%CI 0.494– 0.737), while the correlation of the total score in the two periods was considered moderate (0.47). The intraclass correlation coefficient was 0.50. CONCLUSIONS The translated and cross-culturally adapted version of the instrument to spoken Brazilian Portuguese was considered valid and reliable to be used for assessment within the Brazilian population diagnosed with type 2 diabetes mellitus. The use of a web tool (e-Surv) for recording the Expert Committee responses as well as the responses in the validation tests proved

  3. The nonequilibrium Ehrenfest gas: A chaotic model with flat obstacles?

    NASA Astrophysics Data System (ADS)

    Bianca, Carlo; Rondoni, Lamberto

    2009-03-01

    It is known that the nonequilibrium version of the Lorentz gas (a billiard with dispersing obstacles [Ya. G. Sinai, Russ. Math. Surv. 25, 137 (1970)], electric field, and Gaussian thermostat) is hyperbolic if the field is small [N. I. Chernov, Ann. Henri Poincare 2, 197 (2001)]. Differently the hyperbolicity of the nonequilibrium Ehrenfest gas constitutes an open problem since its obstacles are rhombi and the techniques so far developed rely on the dispersing nature of the obstacles [M. P. Wojtkowski, J. Math. Pures Appl. 79, 953 (2000)]. We have developed analytical and numerical investigations that support the idea that this model of transport of matter has both chaotic (positive Lyapunov exponent) and nonchaotic steady states with a quite peculiar sensitive dependence on the field and on the geometry, not observed before. The associated transport behavior is correspondingly highly irregular, with features whose understanding is of both theoretical and technological interests.

  4. Privacy Sensitive Surveillance for Assisted Living - A Smart Camera Approach

    NASA Astrophysics Data System (ADS)

    Fleck, Sven; Straßer, Wolfgang

    An elderly woman wanders about aimlessly in a home for assisted living. Suddenly, she collapses on the floor of a lonesome hallway. Usually it can take over two hours until a night nurse passes this spot on her next inspection round. But in this case she is already on site after two minutes, ready to help. She has received an alert message on her beeper: "Inhabitant fallen in hallway 2b". The source: the SmartSurv distributed network of smart cameras for automated and privacy respecting video analysis.Welcome to the future of smart surveillance Although this scenario is not yet daily practice, it shall make clear how such systems will impact the safety of the elderly without the privacy intrusion of traditional video surveillance systems.

  5. Road safety control: Application in urban environment in Greece

    NASA Astrophysics Data System (ADS)

    Charisoudis, A.; Mintsis, G.; Basbas, S.; Taxiltaris, Ch.

    2013-01-01

    The purpose of this paper is to determine what is and what is not a "road safety control" on the one hand and on the other hand to examine the procedure of the realization of this control in different countries in the level of the organization as well as in the level of the praxis through the Road Safety Manuals of each country. The countries under examination are: The United Kinghdom, Danish, U.S.A, Australia and New Zeeland. The Road Safety Manual of the International Organization World Road Association-PIARC is also mentioned. Finally examples of the application of road safety control, which were realized in the frame of the research programs of the research team of the Department of Transportation Engineering, School of Rural and Surveing, Aristotle University of Thessaloniki in the town of Aridea, are given.(in Greeks)

  6. Phenotyping transgenic wheat for drought resistance.

    PubMed

    Saint Pierre, Carolina; Crossa, José L; Bonnett, David; Yamaguchi-Shinozaki, Kazuko; Reynolds, Matthew P

    2012-03-01

    Realistic experimental protocols to screen for drought adaptation in controlled conditions are crucial if high throughput phenotyping is to be used for the identification of high performance lines, and is especially important in the evaluation of transgenes where stringent biosecurity measures restrict the frequency of open field trials. Transgenic DREB1A-wheat events were selected under greenhouse conditions by evaluating survival and recovery under severe drought (SURV) as well as for water use efficiency (WUE). Greenhouse experiments confirmed the advantages of transgenic events in recovery after severe water stress. Under field conditions, the group of transgenic lines did not generally outperform the controls in terms of grain yield under water deficit. However, the events selected for WUE were identified as lines that combine an acceptable yield-even higher yield (WUE-11) under well irrigated conditions-and stable performance across the different environments generated by the experimental treatments.

  7. Stratigraphical evidence of late Amazonian periglaciation and glaciation in the Astapus Colles region of Mars

    NASA Astrophysics Data System (ADS)

    Soare, Richard J.; Osinski, Gordon R.

    2009-07-01

    Recent modeling of the meteorological conditions during and following times of high obliquity suggests that an icy mantle could have been emplaced in western Utopia Planitia by atmospheric deposition during the late Amazonian period [Costard, F.M., Forget, F., Madeleine, J.B., Soare, R.J., Kargel, J.S., 2008. Lunar Planet. Sci. 39. Abstract 1274; Madeleine, B., Forget, F., Head, J.W., Levrard, B., Montmessin, F., 2007. Lunar Planet. Sci. 38. Abstract 1778]. Astapus Colles (ABa) is a late Amazonian geological unit - located in this hypothesized area of accumulation - that comprises an icy mantle tens of meters thick [Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888]. For the most part, this unit drapes the early Amazonian Vastitas Borealis interior unit (ABvi); to a lesser degree it overlies the early Amazonian Vastitas Borealis marginal unit (ABvm) and the early to late Hesperian UP plains unit HBu2 [Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888]. Landscapes possibly modified by late-Amazonian periglacial processes [Costard, F.M., Kargel, J.S., 1995. Icarus 114, 93-112; McBride, S.A., Allen, C.C., Bell, M.S., 2005. Lunar Planet. Sci. 36. Abstract 1090; Morgenstern, A., Hauber, E., Reiss, D., van Gasselt, S., Grosse, G., Schirrmeister, L., 2007. J. Geophys. Res. 112, doi:10.1029/2006JE002869. E06010; Seibert, N.M., Kargel, J.S., 2001. Geophys. Res. Lett. 28, 899-902; Soare, R.J., Kargel, J.S., Osinski, G.R., Costard, F., 2007. Icarus 191, 95-112; Soare, R.J., Osinski, G.R., Roehm, C.L., 2008. Earth Planet. Sci. Lett. 272, 382-393] and glacial processes [Milliken, R.E., Mustard, J.F., Goldsby, D.L., 2003. J. Geophys. Res. 108 (E6), doi:10.1029/2002JE002005. 5057; Mustard, J.F., Cooper, C.D., Rifkin, M.K., 2001. Nature 412, 411-414; Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888] have been reported within the region. Researchers have assumed that the

  8. Defining desired genetic gains for rainbow trout breeding objective using analytic hierarchy process.

    PubMed

    Sae-Lim, P; Komen, H; Kause, A; van Arendonk, J A M; Barfoot, A J; Martin, K E; Parsons, J E

    2012-06-01

    Distributing animals from a single breeding program to a global market may not satisfy all producers, as they may differ in market objectives and farming environments. Analytic hierarchy process (AHP) is used to estimate preferences, which can be aggregated to consensus preference values using weighted goal programming (WGP). The aim of this study was to use an AHP-WGP based approach to derive desired genetic gains for rainbow trout breeding and to study whether breeding trait preferences vary depending on commercial products and farming environments. Two questionnaires were sent out. Questionnaire-A (Q-A) was distributed to 178 farmers from 5 continents and used to collect information on commercial products and farming environments. In this questionnaire, farmers were asked to rank the 6 most important traits for genetic improvement from a list of 13 traits. Questionnaire B (Q-B) was sent to all farmers who responded to Q-A (53 in total). For Q-B, preferences of the 6 traits were obtained using pairwise comparison. Preference intensity was given to quantify (in % of a trait mean; G%) the degree to which 1 trait is preferred over the other. Individual preferences, social preferences, and consensus preferences (Con-P) were estimated using AHP and WGP. Desired gains were constructed by multiplying Con-P by G%. The analysis revealed that the 6 most important traits were thermal growth coefficient (TGC), survival (Surv), feed conversion ratio (FCR), condition factor (CF), fillet percentage (FIL%), and late maturation (LMat). Ranking of traits based on average Con-P values were Surv (0.271), FCR (0.246), TGC (0.246), LMat (0.090), FIL% (0.081), and CF (0.067). Corresponding desired genetic gains (in % of trait mean) were 1.63, 1.87, 1.67, 1.29, 0.06, and 0.33%, respectively. The results from Con-P values show that trait preferences may vary for different types of commercial production or farming environments. This study demonstrated that combination of AHP and WGP can

  9. Incidence and prevalence of Toxoplasma gondii infection in women in France, 1980-2020: model-based estimation.

    PubMed

    Nogareda, F; Le Strat, Y; Villena, I; De Valk, H; Goulet, V

    2014-08-01

    Toxoplasmosis is a worldwide zoonosis due to Toxoplasma gondii, a ubiquitous protozoan parasite of warm-blooded animals including humans. In pregnant women, primary infection can cause congenital toxoplasmosis resulting in severe malformations in the newborn. Since 1978, public health authorities in France have implemented a congenital toxoplasmosis prevention programme, including monthly serological screening of all seronegative pregnant women, and treatment in case of seroconversion. However, this programme does not produce systematic surveillance data on incidence and prevalence. Our objective was to estimate the incidence and prevalence of T. gondii infection, and the incidence of seroconversion during pregnancy in women in France. We used a catalytic model to estimate incidence and prevalence of Toxoplasma infection between 1980 and 2020 in women of childbearing age. We used age- and time-specific seroprevalence data obtained from the National Perinatal Surveys (NPS) conducted in 1995, 2003 and 2010. We assumed that incidence depends both on age and calendar time, and can be expressed as the product of two unknown functions. We also estimated incidence of seroconversion during pregnancy in 2010 from the NPS and the National Surveillance of Congenital Toxoplasmosis (ToxoSurv). We combined data of 42208 women aged 15-45 years with serology available from the three NPS. For women aged 30 years the modelled incidence decreased from 7·5/1000 susceptible women in 1980 to 3·5/1000 in 2000. In 2010 the incidence was 2·4/1000. The predicted incidence and prevalence for 2020 was 1·6/1000 and 27%, respectively. The incidence of seroconversion during pregnancy in 2010 was estimated at 2·1/1000 susceptible pregnant women (95% CI 1·3-3·1) from the NPS and 1·9 (95% CI 1·8-2·1) from ToxoSurv. Incidence and prevalence of Toxoplasma infection has decreased markedly during the last 30 years. This decrease may be explained by a lower exposure to the parasite by changes

  10. Lose to win: marT pseudogenization in Salmonella enterica serovar Typhi contributed to the surV-dependent survival to H2O2, and inside human macrophage-like cells.

    PubMed

    Ortega, A P; Villagra, N A; Urrutia, I M; Valenzuela, L M; Talamilla-Espinoza, A; Hidalgo, A A; Rodas, P I; Gil, F; Calderón, I L; Paredes-Sabja, D; Mora, G C; Fuentes, J A

    2016-11-01

    The difference in host range between Salmonella enterica serovar Typhimurium (S. Typhimurium) and Salmonella enterica serovar Typhi (S. Typhi) can be partially attributed to the gain of functions, to the loss of functions (i.e. pseudogenization), or to a combination of both processes. As previously reported, the loss of functions by pseudogenization may play a role in bacterial evolution, especially in host-restricted pathogens such as S. Typhi. The marT-fidL operon, located at the SPI-3, encodes the MarT transcriptional regulator and a hypothetical protein (i.e. FidL) with no significant similarities to known proteins, respectively. Even though predicted S. Typhimurium FidL exhibit 99.4% identity with S. Typhi FidL, marT has been annotated as a pseudogene in S. Typhi. In this work, we found that S. Typhi expressing S. Typhimurium marT-fidL exhibited an increased accumulation of reactive oxygen species (ROS), leading to a decreased survival in presence of H2O2. Moreover, we found that that the presence of a functional copy of S. Typhimurium marT-fidL in S. Typhi resulted in a repression of surV (STY4039), an ORF found in the S. Typhi SPI-3 but absent from S. Typhimurium SPI-3, that contribute to the resistance to H2O2 by decreasing the accumulation of ROS. Finally, we observed that the presence of S. Typhimurium marT-fidL in S. Typhi negatively affected the survival inside macrophage-like cells, but not in epithelial cells, after 24h post infection. Therefore, this work provides evidence arguing that marT pseudogenization in Salmonella Typhi contributed to the surV-dependent survival against H2O2, and inside human macrophage-like cells. This is a good example of how the loss of functions (marT pseudogenization) and the gain of functions (presence of surV) might contribute to phenotypic changes improving virulence.

  11. Self-reported attitudes, skills and use of evidence-based practice among Canadian doctors of chiropractic: a national survey

    PubMed Central

    Bussières, André E.; Terhorst, Lauren; Leach, Matthew; Stuber, Kent; Evans, Roni; Schneider, Michael J.

    2015-01-01

    Objectives: To identify Canadian chiropractors’ attitudes, skills and use of evidence based practice (EBP), as well as their level of awareness of previously published chiropractic clinical practice guidelines (CPGs). Methods: 7,200 members of the Canadian Chiropractic Association were invited by e-mail to complete an online version of the Evidence Based practice Attitude & utilisation SurvEy (EBASE); a valid and reliable measure of participant attitudes, skills and use of EBP. Results: Questionnaires were completed by 554 respondents. Most respondents (>75%) held positive attitudes toward EBP. Over half indicated a high level of self-reported skills in EBP, and over 90% expressed an interest in improving these skills. A majority of respondents (65%) reported over half of their practice was based on evidence from clinical research, and only half (52%) agreed that chiropractic CPGs significantly impacted on their practice. Conclusions: While most Canadian chiropractors held positive attitudes towards EBP, believed EBP was useful, and were interested in improving their skills in EBP, many did not use research evidence or CPGs to guide clinical decision making. Our findings should be interpreted cautiously due to the low response rate. PMID:26816412

  12. Injection parameters and virus dependent choice of promoters to improve neuron targeting in the nonhuman primate brain.

    PubMed

    Lerchner, W; Corgiat, B; Der Minassian, V; Saunders, R C; Richmond, B J

    2014-03-01

    We, like many others, wish to use modern molecular methods to alter neuronal functionality in primates. For us, this requires expression in a large proportion of the targeted cell population. Long generation times make germline modification of limited use. The size and intricate primate brain anatomy poses additional challenges. We surved methods using lentiviruses and serotypes of adeno-associated viruses (AAVs) to introduce active molecular material into cortical and subcortical regions of old-world monkey brains. Slow injections of AAV2 give well-defined expression of neurons in the cortex surrounding the injection site. Somewhat surprisingly we find that in the monkey the use of cytomegalovirus promoter in lentivirus primarily targets glial cells but few neurons. In contrast, with a synapsin promoter fragment the lentivirus expression is neuron specific at high transduction levels in all cortical layers. We also achieve specific targeting of tyrosine hydroxlase (TH)- rich neurons in the locus coeruleus and substantia nigra with a lentvirus carrying a fragment of the TH promoter. Lentiviruses carrying neuron specific promoters are suitable for both cortical and subcortical injections even when injected quickly.

  13. Marginal Bayesian nonparametric model for time to disease arrival of threatened amphibian populations.

    PubMed

    Zhou, Haiming; Hanson, Timothy; Knapp, Roland

    2015-12-01

    The global emergence of Batrachochytrium dendrobatidis (Bd) has caused the extinction of hundreds of amphibian species worldwide. It has become increasingly important to be able to precisely predict time to Bd arrival in a population. The data analyzed herein present a unique challenge in terms of modeling because there is a strong spatial component to Bd arrival time and the traditional proportional hazards assumption is grossly violated. To address these concerns, we develop a novel marginal Bayesian nonparametric survival model for spatially correlated right-censored data. This class of models assumes that the logarithm of survival times marginally follow a mixture of normal densities with a linear-dependent Dirichlet process prior as the random mixing measure, and their joint distribution is induced by a Gaussian copula model with a spatial correlation structure. To invert high-dimensional spatial correlation matrices, we adopt a full-scale approximation that can capture both large- and small-scale spatial dependence. An efficient Markov chain Monte Carlo algorithm with delayed rejection is proposed for posterior computation, and an R package spBayesSurv is provided to fit the model. This approach is first evaluated through simulations, then applied to threatened frog populations in Sequoia-Kings Canyon National Park.

  14. Late Pleistocene eolian features in southeastern Maryland and Chesapeake Bay region indicate strong WNW-NW winds accompanied growth of the Laurentide Ice Sheet

    USGS Publications Warehouse

    Markewich, H.W.; Litwin, R.J.; Pavich, M.J.; Brook, G.A.

    2009-01-01

    Inactive parabolic dunes are present in southeastern Maryland, USA, along the east bank of the Potomac River. More elongate and finer-grained eolian deposits and paha-like ridges characterize the Potomac River-Patuxent River upland and the west side of Chesapeake Bay. These ridges are streamlined erosional features, veneered with eolian sediment and interspersed with dunes in the low-relief headwaters of Potomac- and Patuxent-river tributaries. Axis data for the dunes and ridges indicate formation by WNW-NW winds. Optically stimulated luminescence and radiocarbon age data suggest dune formation from ??? 33-15??ka, agreeing with the 30-13??ka ages Denny, C.S., Owens, J.P., Sirkin, L., Rubin, M., 1979. The Parsonburg Sand in the central Delmarva Peninsula, Maryland and Delaware. U.S. Geol. Surv. Prof. Pap. 1067-B, 16??pp. suggested for eolian deposits east of Chesapeake Bay. Age range and paleowind direction(s) for eolian features in the Bay region approximate those for late Wisconsin loess in the North American midcontinent. Formation of midcontinent loess and Bay-region eolian features was coeval with rapid growth of the Laurentide Ice Sheet and strong cooling episodes (??18O minima) evident in Greenland ice cores. Age and paleowind-direction coincidence, for eolian features in the midcontinent and Bay region, indicates strong mid-latitude WNW-NW winds for several hundred kilometers south of the Laurentide glacial terminus that were oblique to previously simulated anticyclonic winds for the last glacial maximum.

  15. Evaluating the Psychometric Properties of the Evidence-Based Practice Attitude and Utilization Survey

    PubMed Central

    Leach, Matthew; Bussières, Andre; Evans, Roni; Schneider, Michael J.

    2016-01-01

    Abstract Objective: Most health professions recognize the value of evidence-based practice (EBP), yet the uptake of EBP across most health disciplines has been suboptimal. To improve EBP uptake, it is important to first understand the many dimensions that affect EBP use. The Evidence-Based practice Attitude and utilization SurvEy (EBASE) was designed to measure the attitudes, skills, and use of EBP among practitioners of complementary and alternative medicine (CAM); however, the dimensionality of the instrument is not well understood. The aim of the current research was to examine the psychometric properties of the attitudes, skills, and use subscales of EBASE. Design: This was a secondary analysis of data obtained from the administration of EBASE. Data were examined using principal components analyses and confirmatory methods. Internal consistency reliabilities of resultant subscales were also computed. Participants: 1314 U.S. chiropractors and 554 Canadian chiropractors. Results: A unidimensional structure best fit the attitudes and use subscales. Skills subscale items were best represented by subscales with a multidimensional structure. Specifically, the skills construct was best modeled with three dimensions (identification of the research question, locating research, and application of EBP). All subscales had acceptable internal consistency reliability estimates. Conclusions: The findings support the modification of the scoring guidelines for the original EBASE. These changes are likely to result in a more accurate measure of EBP attitudes, skills, and use among chiropractors, and possibly CAM providers more generally. PMID:26982906

  16. Phosphorus zoning in olivine of Kilauea Iki lava lake, Hawaii

    NASA Astrophysics Data System (ADS)

    Fabbrizio, Alessandro; Beckett, John R.; Baker, Michael B.; Stolper, Edward M.

    2010-05-01

    low P chambers and P enriched zones were also observed; near the margins of the crystals is possible to find the presence of discontinuous sets of P-enriched bands that generally outline euhedral crystal forms; some crystals are characterized by P-enriched ghosts of relict crystals in their interior that are associated with probable undercooling and/or with an initial pulse of rapid crystal growth [8, 10]. Phenocrysts and microphenocrysts are frequently unzoned in major and minor divalent cations (Fe, Mg, Mn, Ca, Ni), but all are zoned in P. Variations in Cr and Al correlate spatially with P but are much fainter or absents, in some crystal the P-enriched bands are superimposed with small crystals of chromite (≤1 μm) aligned along the P zoning. Probably these chromites were formed by precipitation from the original Cr and Al bands. In no case was observed Ti zoning. [1] Richter D.H. et al. (1970) US Geol Surv Prof Pap 537-E, 73 p. [2] Richter D.H., Moore J.G. (1966) US Geol Surv Prof Pap 537-B, 26 p. [3] Helz R.T. (1980) Bull Volcanol 43-4, 675-701. [4] Helz R.T. et al. (1984) US Geol Surv Open File Rep 84-484, 72 p. [5] Hardee H.C. et al. (1981) Geophys Res Lett 8, 1211-1214. [6] Helz R.T., Wright T.L. (1983) US Geol Surv Open File Rep 83-326, 66 p. [7] Helz R.T. (1987) Geochem Soc Spec Pub 1, 241-258. [8] Beckett J.R. et al. (2008) LPSC abs. 1726. [9] Mccanta M.C. et al. (2008) LPSC abs. 1807. [10] Milmann-Barris M.S. et al. (2008) CMP 155, 739-765. [11] Mccanta M.C. et al. (2008) GCA 72-12, S1, A610.

  17. Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates

    PubMed Central

    Reed, Carrie; Kirley, Pam Daily; Aragon, Deborah; Meek, James; Farley, Monica M.; Ryan, Patricia; Collins, Jim; Lynfield, Ruth; Baumbach, Joan; Zansky, Shelley; Bennett, Nancy M.; Fowler, Brian; Thomas, Ann; Lindegren, Mary L.; Atkinson, Annette; Finelli, Lyn; Chaves, Sandra S.

    2015-01-01

    Diagnostic test sensitivity affects rate estimates for laboratory-confirmed influenza–associated hospitalizations. We used data from FluSurv-NET, a national population-based surveillance system for laboratory-confirmed influenza hospitalizations, to capture diagnostic test type by patient age and influenza season. We calculated observed rates by age group and adjusted rates by test sensitivity. Test sensitivity was lowest in adults >65 years of age. For all ages, reverse transcription PCR was the most sensitive test, and use increased from <10% during 2003–2008 to ≈70% during 2009–2013. Observed hospitalization rates per 100,000 persons varied by season: 7.3–50.5 for children <18 years of age, 3.0–30.3 for adults 18–64 years, and 13.6–181.8 for adults >65 years. After 2009, hospitalization rates adjusted by test sensitivity were ≈15% higher for children <18 years, ≈20% higher for adults 18–64 years, and ≈55% for adults >65 years of age. Test sensitivity adjustments improve the accuracy of hospitalization rate estimates. PMID:26292017

  18. Parametric regression model for survival data: Weibull regression model as an example

    PubMed Central

    2016-01-01

    Weibull regression model is one of the most popular forms of parametric regression model that it provides estimate of baseline hazard function, as well as coefficients for covariates. Because of technical difficulties, Weibull regression model is seldom used in medical literature as compared to the semi-parametric proportional hazard model. To make clinical investigators familiar with Weibull regression model, this article introduces some basic knowledge on Weibull regression model and then illustrates how to fit the model with R software. The SurvRegCensCov package is useful in converting estimated coefficients to clinical relevant statistics such as hazard ratio (HR) and event time ratio (ETR). Model adequacy can be assessed by inspecting Kaplan-Meier curves stratified by categorical variable. The eha package provides an alternative method to model Weibull regression model. The check.dist() function helps to assess goodness-of-fit of the model. Variable selection is based on the importance of a covariate, which can be tested using anova() function. Alternatively, backward elimination starting from a full model is an efficient way for model development. Visualization of Weibull regression model after model development is interesting that it provides another way to report your findings. PMID:28149846

  19. Generalized accelerated failure time spatial frailty model for arbitrarily censored data.

    PubMed

    Zhou, Haiming; Hanson, Timothy; Zhang, Jiajia

    2016-03-18

    Flexible incorporation of both geographical patterning and risk effects in cancer survival models is becoming increasingly important, due in part to the recent availability of large cancer registries. Most spatial survival models stochastically order survival curves from different subpopulations. However, it is common for survival curves from two subpopulations to cross in epidemiological cancer studies and thus interpretable standard survival models can not be used without some modification. Common fixes are the inclusion of time-varying regression effects in the proportional hazards model or fully nonparametric modeling, either of which destroys any easy interpretability from the fitted model. To address this issue, we develop a generalized accelerated failure time model which allows stratification on continuous or categorical covariates, as well as providing per-variable tests for whether stratification is necessary via novel approximate Bayes factors. The model is interpretable in terms of how median survival changes and is able to capture crossing survival curves in the presence of spatial correlation. A detailed Markov chain Monte Carlo algorithm is presented for posterior inference and a freely available function frailtyGAFT is provided to fit the model in the R package spBayesSurv. We apply our approach to a subset of the prostate cancer data gathered for Louisiana by the surveillance, epidemiology, and end results program of the National Cancer Institute.

  20. Unbiased Prediction and Feature Selection in High-Dimensional Survival Regression

    PubMed Central

    Laimighofer, Michael; Krumsiek, Jan; Theis, Fabian J.

    2016-01-01

    Abstract With widespread availability of omics profiling techniques, the analysis and interpretation of high-dimensional omics data, for example, for biomarkers, is becoming an increasingly important part of clinical medicine because such datasets constitute a promising resource for predicting survival outcomes. However, early experience has shown that biomarkers often generalize poorly. Thus, it is crucial that models are not overfitted and give accurate results with new data. In addition, reliable detection of multivariate biomarkers with high predictive power (feature selection) is of particular interest in clinical settings. We present an approach that addresses both aspects in high-dimensional survival models. Within a nested cross-validation (CV), we fit a survival model, evaluate a dataset in an unbiased fashion, and select features with the best predictive power by applying a weighted combination of CV runs. We evaluate our approach using simulated toy data, as well as three breast cancer datasets, to predict the survival of breast cancer patients after treatment. In all datasets, we achieve more reliable estimation of predictive power for unseen cases and better predictive performance compared to the standard CoxLasso model. Taken together, we present a comprehensive and flexible framework for survival models, including performance estimation, final feature selection, and final model construction. The proposed algorithm is implemented in an open source R package (SurvRank) available on CRAN. PMID:26894327

  1. Genetic parameters and genetic trends in the Chinese × European Tiameslan composite pig line. I. Genetic parameters

    PubMed Central

    Zhang, Siqing; Bidanel, Jean-Pierre; Burlot, Thierry; Legault, Christian; Naveau, Jean

    2000-01-01

    Genetic parameters of body weight at 4 (W4 w), 8 (W8 w) and 22 (W22 w) weeks of age, days from 20 to 100 kg (DT), average backfat thickness at 100 kg (ABT), teat number (TEAT), number of good teats (GTEAT), total number of piglets born (TNB), born alive (NBA) and weaned (NW) per litter, and birth to weaning survival rate (SURV) were estimated in the Chinese × European Tiameslan composite line using restricted maximum likelihood methodology applied to a multiple trait animal model. Performance data from a total of 4 881 males and 4 799 females from 1 341 litters were analysed. Different models were fitted to the data in order to estimate the importance of maternal effects on production traits, as well as genetic correlations between male and female performance. The results showed the existence of significant maternal effects on W4w, W8w and ABT and of variance heterogeneity between sexes for W22w, DT, ABT and GTEAT. Genetic correlations between sexes were 0.79, 0.71 and 0.82, respectively, for W22w, DT and ABT and above 0.90 for the other traits. Heritability estimates were larger than (ABT and TEAT) or similar to (other traits) average literature values. Some genetic antagonism was evidenced between production traits, particularly W4w, W8w and ABT, and reproductive traits. PMID:14736406

  2. Résultats à long terme de la transplantation hépatique orthotopique durant l'ère de la cyclosporine12

    PubMed Central

    Lerut, J.; Stieber, A. C.; Makowka, L.; Esquivel, C. O.; Iwatsuki, S.; Gordon, R. D.; Starzl, T. E.

    2010-01-01

    Résumé 313 patients ont subi consécutivement à l'Université de Pittsburgh 393 transplantations hépatiques orthotopiques (THO) durant l'ère de la cyclosporine 1980–1984. Tous les patients ont été suivis au moins durant trois ans après la transplantation ou jusqu'au moment de leur décès. 216 (69%) des 313 patients ont survécu au moins une année après la THO; 26 patients (12%) sont décédés après la première année postopératoire. Les résultats de la transplantation hépatique pour les diverses indications sont discutés. Les taux de survie actuarielle à cinq ans pour les maladies métaboliques, les atrésies des voies biliaires, la cirrhose biliaire primitive, la cholangite sclérosante primitive, la cirrhose posthépatitique et les tumeurs hépatobiliaires primitives sont respectivement de 75%, 68%, 60%, 58,9%, 53,2%, 23,8%. La récidive de la maladie primaire après THO pour maladie hépatique bénigne est, à l'exception de la cirrhose posthépatique B et le syndrome de Budd-Chiari, rare; elle est par contre élevée après THO réalisée pour maladie hépatobiliaire maligne. 27% (86) des 313 patients ont subi 112 retransplantations hépatiques durant la période du follow-up. 45 (21%) des 216 patients survivant plus qu'une année après la THO ont dû être traités pour un rejet de leur greffon; 18 patients ont dû être retransplantés pour un rejet chronique du greffon. Les complications extrahépatiques, survenant plus d'une année après la transplantation hépatique, sont plutôt rares (19/216 patients – 8,8%). Seulement trois patients ont dû subir une modification de la thérapie d'immunosuppression à cyclosporine pour cause d'insuffisance rénale incontrôlable. La qualité de vie des patients ayant une survie à long terme est excellente. 37 patients de cette série ont survécu au moins cinq ans après la THO. 81% (17/21) des enfants et douze des seize adultes (75%) ont une réintégration familiale, écolière et

  3. Frequent eruptions of Mount Rainier over the last ˜2,600 years

    NASA Astrophysics Data System (ADS)

    Sisson, T. W.; Vallance, J. W.

    2009-08-01

    Field, geochronologic, and geochemical evidence from proximal fine-grained tephras, and from limited exposures of Holocene lava flows and a small pyroclastic flow document ten-12 eruptions of Mount Rainier over the last 2,600 years, contrasting with previously published evidence for only 11-12 eruptions of the volcano for all of the Holocene. Except for the pumiceous subplinian C event of 2,200 cal year BP, the late-Holocene eruptions were weakly explosive, involving lava effusions and at least two block-and-ash pyroclastic flows. Eruptions were clustered from ˜2,600 to ˜2,200 cal year BP, an interval referred to as the Summerland eruptive period that includes the youngest lava effusion from the volcano. Thin, fine-grained tephras are the only known primary volcanic products from eruptions near 1,500 and 1,000 cal year BP, but these and earlier eruptions were penecontemporaneous with far-traveled lahars, probably created from newly erupted materials melting snow and glacial ice. The most recent magmatic eruption of Mount Rainier, documented geochemically, was the 1,000 cal year BP event. Products from a proposed eruption of Mount Rainier between AD 1820 and 1854 (X tephra of Mullineaux (US Geol Surv Bull 1326:1-83, 1974)) are redeposited C tephra, probably transported onto young moraines by snow avalanches, and do not record a nineteenth century eruption. We found no conclusive evidence for an eruption associated with the clay-rich Electron Mudflow of ˜500 cal year BP, and though rare, non-eruptive collapse of unstable edifice flanks remains as a potential hazard from Mount Rainier.

  4. Frequent eruptions of Mount Rainier over the last ∼2,600 years

    USGS Publications Warehouse

    Sisson, T.W.; Vallance, J.W.

    2009-01-01

    Field, geochronologic, and geochemical evidence from proximal fine-grained tephras, and from limited exposures of Holocene lava flows and a small pyroclastic flow document ten–12 eruptions of Mount Rainier over the last 2,600 years, contrasting with previously published evidence for only 11–12 eruptions of the volcano for all of the Holocene. Except for the pumiceous subplinian C event of 2,200 cal year BP, the late-Holocene eruptions were weakly explosive, involving lava effusions and at least two block-and-ash pyroclastic flows. Eruptions were clustered from ∼2,600 to ∼2,200 cal year BP, an interval referred to as the Summerland eruptive period that includes the youngest lava effusion from the volcano. Thin, fine-grained tephras are the only known primary volcanic products from eruptions near 1,500 and 1,000 cal year BP, but these and earlier eruptions were penecontemporaneous with far-traveled lahars, probably created from newly erupted materials melting snow and glacial ice. The most recent magmatic eruption of Mount Rainier, documented geochemically, was the 1,000 cal year BP event. Products from a proposed eruption of Mount Rainier between AD 1820 and 1854 (X tephra of Mullineaux (US Geol Surv Bull 1326:1–83, 1974)) are redeposited C tephra, probably transported onto young moraines by snow avalanches, and do not record a nineteenth century eruption. We found no conclusive evidence for an eruption associated with the clay-rich Electron Mudflow of ∼500 cal year BP, and though rare, non-eruptive collapse of unstable edifice flanks remains as a potential hazard from Mount Rainier.

  5. Episodic tectonic plate reorganizations driven by mantle convection

    NASA Astrophysics Data System (ADS)

    King, Scott D.; Lowman, Julian P.; Gable, Carl W.

    2002-10-01

    Periods of relatively uniform plate motion were interrupted several times throughout the Cenozoic and Mesozoic by rapid plate reorganization events [R. Hey, Geol. Soc. Am. Bull. 88 (1977) 1404-1420; P.A. Rona, E.S. Richardson, Earth Planet. Sci. Lett. 40 (1978) 1-11; D.C. Engebretson, A. Cox, R.G. Gordon, Geol. Soc. Am. Spec. Pap. 206 (1985); R.G. Gordon, D.M. Jurdy, J. Geophys. Res. 91 (1986) 12389-12406; D.A. Clague, G.B. Dalrymple, US Geol. Surv. Prof. Pap. 1350 (1987) 5-54; J.M. Stock, P. Molnar, Nature 325 (1987) 495-499; C. Lithgow-Bertelloni, M.A. Richards, Geophys. Res. Lett. 22 (1995) 1317-1320; M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. It has been proposed that changes in plate boundary forces are responsible for these events [M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. We present an alternative hypothesis: convection-driven plate motions are intrinsically unstable due to a buoyant instability that develops as a result of the influence of plates on an internally heated mantle. This instability, which has not been described before, is responsible for episodic reorganizations of plate motion. Numerical mantle convection experiments demonstrate that high-Rayleigh number convection with internal heating and surface plates is sufficient to induce plate reorganization events, changes in plate boundary forces, or plate geometry, are not required.

  6. Attitudes, skill and use of evidence-based practice among US Western herbal medicine providers: a national survey.

    PubMed

    Snow, James E; Leach, Matthew J; Clare, Bevin A

    2017-03-01

    Background Evidence-based practice (EBP) has been the focus of increasing attention in the teaching and delivery of both complementary and conventional healthcare. Western herbal medicine (WHM) is a system of complementary healthcare rooted in tradition. How WHM practitioners perceive, are prepared for, and use EBP, has to date been largely ignored. We therefore examined the use, opinion, skills, and training in EBP, and barriers and facilitators of EBP uptake, among herbal practitioners in the United States (US). Methods The study utilized a cross-sectional, descriptive survey design. A sample of US clinical herbalists was invited to complete a validated online questionnaire, the Evidence-Based practice Attitude and utilization SurvEy (EBASE). Results Seventy-four US herbal practitioners completed the survey (response rate=35 %). Participants demonstrated a generally positive attitude toward EBP (median attitude subscore 31 [possible range=8-40]), a moderate to high level of self-assessed skill in EBP (median skill subscore 46 [13-65]) and a moderate level of EBP uptake (median use subscore 12 [0-24]). Apart from a lack of clinical evidence in herbal medicine, there were few perceived barriers to EBP uptake among herbal practitioners. Access to the Internet, online databases and full-text journal articles were considered most useful in facilitating the uptake of EBP in WHM practice. Conclusions Respondents' attitudes, skill level, and uptake of EBP were generally consistent with other complementary and alternative medicine providers. Educational initiatives, including those focused on the appraisal and application of evidence, may help to optimize the use of EBP among WHM practitioners.

  7. A Reassessment of 20th Century Global Sea-Level Change

    NASA Astrophysics Data System (ADS)

    Hay, C.; Morrow, E.; Kopp, R. E.; Mitrovica, J. X.

    2015-12-01

    Climatic change in the 20th century is directly and indirectly observable in multiple aspects of the climate system. Some of these changes, such as global mean surface temperature, are widely studied and understood, while others, such as global mean sea-level change (GMSL), remain uncertain. Until the mid-1990s, with the advent of satellite altimeter observations of a significant percentage of the global ocean, point observations of global sea-level change through tide gauges were the primary means of monitoring the changing height of the sea surface relative to the sea floor. Traditionally, there have been two approaches for estimating GMSL from these temporally and spatially sparse tide gauge records. The first approach uses such records to obtain a global mean value by computing and summing representative regional averages through time (e.g., Jevrejeva et al., GRL, 2008). The second approach uses the dominant spatial patterns of sea surface heights from 20 years of satellite altimetry data to interpolate between tide gauge records to reconstruct global sea level over the century (e.g., Church and White, Surv. Geophys., 2011). However, the GMSL estimates obtained using these two methods differ by ~0.5 mm/yr from the mean global rate achieved by summing the data- and model-derived estimates of the underlying contributions (e.g., thermal expansion, mass flux from land ice, etc.) (IPCC, 2014). Here we describe a third approach that estimates GMSL using two probabilistic approaches based on fingerprinting the underlying source contributions from the spatiotemporal patterns of sea-level change captured by the tide gauge records (Hay et al., Nature, 2015). Our revised GMSL rate estimate of 1.2 ± 0.2 mm/yr over 1901-1990 closes the sea-level budget and maintains a good fit with the tide gauge record over the 20th century.

  8. Nucleus-nucleus cold fusion reactions analyzed with the l-dependent 'fusion by diffusion' model

    SciTech Connect

    Cap, T.; Siwek-Wilczynska, K.; Wilczynski, J.

    2011-05-15

    We present a modified version of the Fusion by Diffusion (FBD) model aimed at describing the synthesis of superheavy nuclei in cold fusion reactions, in which a low excited compound nucleus emits only one neutron. The modified FBD model accounts for the angular momentum dependence of three basic factors determining the evaporation residue cross section: the capture cross section {sigma}{sub cap}(l), the fusion probability P{sub fus}(l), and the survival probability P{sub surv}(l). The fusion hindrance factor, the inverse of P{sub fus}(l), is treated in terms of thermal fluctuations in the shape degrees of freedom and is expressed as a solution of the Smoluchowski diffusion equation. The l dependence of P{sub fus}(l) results from the l-dependent potential energy surface of the colliding system. A new parametrization of the distance of starting point of the diffusion process is introduced. An analysis of a complete set of 27 excitation functions for production of superheavy nuclei in cold fusion reactions, studied in experiments at GSI Darmstadt, RIKEN Tokyo, and LBNL Berkeley, is presented. The FBD model satisfactorily reproduces shapes and absolute cross sections of all the cold fusion excitation functions. It is shown that the peak position of the excitation function for a given 1n reaction is determined by the Q value of the reaction and the height of the fission barrier of the final nucleus. This fact could possibly be used in future experiments (with well-defined beam energy) for experimental determination of the fission barrier heights.

  9. Renal and cardiovascular risk predictive value of two different microalbuminuria screening methods in patients with hypertension with/without diabetes in Portugal.

    PubMed

    Polónia, J; Carvalho, D; Nazaré, J; Martins, L; da Silva, P M; Aguiar, C; Manso, M C; Carqueja, T

    2016-11-01

    MicRoAlbuminuria sCreening survEy (RACE) was a multicentre, observational, cross-sectional study conducted in primary health-care settings of Portugal. Here, we present a post-hoc analysis from the RACE study, assessing the renal and cardiovascular (CV) risk predictive value of two different microalbuminuria (MA) screening methods, nephelometry with 24-h urine (MA-24 h) and Micral test with occasional urine (MicralA) in patients with hypertension (HTN) with/without type 2 diabetes mellitus (T2DM). Out of 3065 patients, 1173 (38.3%) were in the HTN group without T2DM (HTN) and 1892 (61.7%) in the HTN group with T2DM (HTN+T2DM). The overall prevalence of MA was 50.6% determined by MicralA and 22.1% with MA-24 h. Urinary albumin excretion data obtained by both techniques correlated significantly (rs=0.586; P<0.001). In all subjects, MicralA showed a sensitivity of 93%, specificity of 62% for detection of MA, with a positive predictive value of 41% and negative predictive value of 97%. With both methods, the presence of MA was independently associated with a higher risk (1.5- to 2.9-fold) of CV and renal organ damage in both HTN and HTN+T2DM groups. MicralA, due to its high sensitivity and negative predictive value, can be considered as a valid and reliable method for MA screening in patients with HTN with/without T2DM.

  10. Influenza-Related Hospitalizations and Poverty Levels - United States, 2010-2012.

    PubMed

    Hadler, James L; Yousey-Hindes, Kimberly; Pérez, Alejandro; Anderson, Evan J; Bargsten, Marisa; Bohm, Susan R; Hill, Mary; Hogan, Brenna; Laidler, Matt; Lindegren, Mary Lou; Lung, Krista L; Mermel, Elizabeth; Miller, Lisa; Morin, Craig; Parker, Erin; Zansky, Shelley M; Chaves, Sandra S

    2016-02-12

    Annual influenza vaccine is recommended for all persons aged ≥6 months in the United States, with recognition that some persons are at risk for more severe disease (1). However, there might be previously unrecognized demographic groups that also experience higher rates of serious influenza-related disease that could benefit from enhanced vaccination efforts. Socioeconomic status (SES) measures that are area-based can be used to define demographic groups when individual SES data are not available (2). Previous surveillance data analyses in limited geographic areas indicated that influenza-related hospitalization incidence was higher for persons residing in census tracts that included a higher percentage of persons living below the federal poverty level (3-5). To determine whether this association occurs elsewhere, influenza hospitalization data collected in 14 FluSurv-NET sites covering 27 million persons during the 2010-11 and 2011-12 influenza seasons were analyzed. The age-adjusted incidence of influenza-related hospitalizations per 100,000 person-years in high poverty (≥20% of persons living below the federal poverty level) census tracts was 21.5 (95% confidence interval [CI]: 20.7-22.4), nearly twice the incidence in low poverty (<5% of persons living below the federal poverty level) census tracts (10.9, 95% CI: 10.3-11.4). This relationship was observed in each surveillance site, among children and adults, and across racial/ethnic groups. These findings suggest that persons living in poorer census tracts should be targeted for enhanced influenza vaccination outreach and clinicians serving these persons should be made aware of current recommendations for use of antiviral agents to treat influenza (6).

  11. PEARS Emission Line Galaxies

    NASA Technical Reports Server (NTRS)

    Pirzkal, Nor; Rothberg, Barry; Ly, Chun; Rhoads, James E.; Malhotra, Sangeeta; Grogin, Norman A.; Dahlen, Tomas; Meurer, Gerhardt R.; Walsh, Jeremy; Hathi, Nimish P.; Cohen, Seth; Belini, Andrea; Holwerda, Benne W.; Straughn, Amber; Mechtley, Matthew

    2012-01-01

    We present a full analysis of the Probing Evolution And Reionization Spectroscopically (PEARS) slitless grism spectroscopic data obtained vl'ith the Advanced Camera for Surveys on HST. PEARS covers fields within both the Great Observatories Origins Deep Survey (GOODS) North and South fields, making it ideal as a random surveY of galaxies, as well as the availability of a wide variety of ancillary observations to support the spectroscopic results. Using the PEARS data we are able to identify star forming galaxies within the redshift volume 0 < z < 1.5. Star forming regions in the PEARS survey are pinpointed independently of the host galaxy. This method allOW8 us to detect the presence of multiple emission line regions (ELRs) within a single galaxy. 1162 [OII], [OIII] and/or H-alpha emission lines have been identified in the PEARS sample of approx 906 galaxies down to a limiting flux of approx 10 - 18 erg/s/sq cm . The ELRs have also been compared to the properties of the host galaxy, including morphology, luminosity, and mass. From this analysis we find three key results: 1) The computed line luminosities show evidence of a flattening in the luminosity function with increasing redshift; 2) The star forming systems show evidence of disturbed morphologies, with star formation occurring predominantly within one effective (half-light) radius. However, the morphologies show no correlation with host stellar mass; and 3) The number density of star forming galaxies with M(*) >= 10(exp 9) Solar M decreases by an order of magnitude at z<=0.5 relative to the number at 0.5 < z < 0.9 in support of the argument for galaxy downsizing.

  12. Late Oligocene OIB-like lavas in northern Idaho

    NASA Astrophysics Data System (ADS)

    Stadnik, S.; Wolff, J. A.; Hart, G. L.

    2008-12-01

    The 26.3 to 25.3 Ma Potlatch volcanics in northern Idaho (Kuffman et al., 2006) consist of a suite of basalts, hawaiites, mugearites, benmoreites, trachytes and nepheline trachytes. The volcanic field was erupted on North American cratonic basement well to the northeast of the regional crustal suture with Phanerozoic terranes accreted during the Mesozoic, and predates Columbia River flood basalt activity in the area by 9 million years. The most primitive Potlatch lavas are porphyritic olivine basalts with 6 percent MgO and strongly OIB-like chemical affinities (La/Nb = 0.69 - 0.76, Th/Ta = 0.92 to 1.08, Pb/Ce = 0.029 to 0.033, 87Sr/86Sr = 0.70367 to 0.70476, 206Pb/204Pb = 19.254 to 19.504). Similarly, intermediate and felsic lavas and pyroclastics closely resemble differentiated members of typical sodic ocean island suites, but have additionally been affected by AFC involving small amounts of regional continental crust, which has acted to increase 87Sr/86Sr up to 0.70516. The Potlatch volcanics are geochemically unlike other regional Cenozoic volcanic suites including Eocene Challis rocks, basalts and rhyolites of the John Day Formation and other volcanic fields around the Blue Mountains to the south and southwest, and the later Columbia River basalts. Their occurrence represents a modification to the southward retreat pattern of early to mid-Cenozoic magmatism in northwestern North America. Kauffman, Bush, and Lewis (2006) ID Geol. Surv. Tech. Rep. 06-7, 11 pp.

  13. The binary fraction, separation distribution, and merger rate of white dwarfs from SPY

    NASA Astrophysics Data System (ADS)

    Maoz, Dan; Hallakoun, Na'ama

    2017-01-01

    From a sample of spectra of 439 white dwarfs (WDs) from the ESO-VLT Supernova-Ia Progenitor surveY (SPY), we measure the maximal changes in radial-velocity (ΔRVmax) between epochs (generally two epochs, separated by up to 470 d), and model the observed ΔRVmax statistics via Monte-Carlo simulations, to constrain the population characteristics of double WDs (DWDs). The DWD fraction among WDs is fbin=0.100 ± 0.020 (1σ, random) +0.02 (systematic), in the separation range ≲ 4 AU within which the data are sensitive to binarity. Assuming the distribution of binary separation, a, is a power-law, dN/da∝aα, at the end of the last common-envelope phase and the start of solely gravitational-wave-driven binary evolution, the constraint by the data is α = -1.3 ± 0.2 (1σ) ±0.2 (systematic). If these parameters extend to small separations, the implied Galactic WD merger rate per unit stellar mass is Rmerge = (1 - 80) × 10-13 yr^{-1} M_⊙ ^{-1} (2σ), with a likelihood-weighted mean of Rmerge = (7 ± 2) × 10-13 yr^{-1} M_⊙ ^{-1} (1σ). The Milky Way's specific Type-Ia supernova (SN Ia) rate is likely RIa ≈ 1.1 × 10-13 yr^{-1} M_⊙ ^{-1} and therefore, in terms of rates, a possibly small fraction of all merging DWDs (e.g. those with massive-enough primary WDs) could suffice to produce most or all SNe Ia.

  14. A 1985-2015 data-driven global reconstruction of GRACE total water storage

    NASA Astrophysics Data System (ADS)

    Humphrey, Vincent; Gudmundsson, Lukas; Isabelle Seneviratne, Sonia

    2016-04-01

    After thirteen years of measurements, the Gravity Recovery and Climate Experiment (GRACE) mission has enabled for an unprecedented view on total water storage (TWS) variability. However, the relatively short record length, irregular time steps and multiple data gaps since 2011 still represent important limitations to a wider use of this dataset within the hydrological and climatological community especially for applications such as model evaluation or assimilation of GRACE in land surface models. To address this issue, we make use of the available GRACE record (2002-2015) to infer local statistical relationships between detrended monthly TWS anomalies and the main controlling atmospheric drivers (e.g. daily precipitation and temperature) at 1 degree resolution (Humphrey et al., in revision). Long-term and homogeneous monthly time series of detrended anomalies in total water storage are then reconstructed for the period 1985-2015. The quality of this reconstruction is evaluated in two different ways. First we perform a cross-validation experiment to assess the performance and robustness of the statistical model. Second we compare with independent basin-scale estimates of TWS anomalies derived by means of combined atmospheric and terrestrial water-balance using atmospheric water vapor flux convergence and change in atmospheric water vapor content (Mueller et al. 2011). The reconstructed time series are shown to provide robust data-driven estimates of global variations in water storage over large regions of the world. Example applications are provided for illustration, including an analysis of some selected major drought events which occurred before the GRACE era. References Humphrey V, Gudmundsson L, Seneviratne SI (in revision) Assessing global water storage variability from GRACE: trends, seasonal cycle, sub-seasonal anomalies and extremes. Surv Geophys Mueller B, Hirschi M, Seneviratne SI (2011) New diagnostic estimates of variations in terrestrial water storage

  15. The "normal" elongation of river basins

    NASA Astrophysics Data System (ADS)

    Castelltort, Sebastien

    2013-04-01

    The spacing between major transverse rivers at the front of Earth's linear mountain belts consistently scales with about half of the mountain half-width [1], despite strong differences in climate and rock uplift rates. Like other empirical measures describing drainage network geometry this result seems to indicate that the form of river basins, among other properties of landscapes, is invariant. Paradoxically, in many current landscape evolution models, the patterns of drainage network organization, as seen for example in drainage density and channel spacing, seem to depend on both climate [2-4] and tectonics [5]. Hovius' observation [1] is one of several unexplained "laws" in geomorphology that still sheds mystery on how water, and rivers in particular, shape the Earth's landscapes. This narrow range of drainage network shapes found in the Earth's orogens is classicaly regarded as an optimal catchment geometry that embodies a "most probable state" in the uplift-erosion system of a linear mountain belt. River basins currently having an aspect away from this geometry are usually considered unstable and expected to re-equilibrate over geological time-scales. Here I show that the Length/Width~2 aspect ratio of drainage basins in linear mountain belts is the natural expectation of sampling a uniform or normal distribution of basin shapes, and bears no information on the geomorphic processes responsible for landscape development. This finding also applies to Hack's [6] law of river basins areas and lengths, a close parent of Hovius' law. [1]Hovius, N. Basin Res. 8, 29-44 (1996) [2]Simpson, G. & Schlunegger, F. J. Geophys. Res. 108, 2300 (2003) [3]Tucker, G. & Bras, R. Water Resour. Res. 34, 2751-2764 (1998) [4]Tucker, G. & Slingerland, R. Water Resour. Res. 33, 2031-2047 (1997) [5]Tucker, G. E. & Whipple, K. X. J. Geophys. Res. 107, 1-1 (2002) [6]Hack, J. US Geol. Surv. Prof. Pap. 294-B (1957)

  16. Redox effect on the Cr isotope proxy: transitional signal of associated cap-carbonates, BIF and black shale, Chuos Formation (Namibia)

    NASA Astrophysics Data System (ADS)

    Rodler, A.; Frei, R.; Gaucher, C.

    2013-12-01

    -rich, ferruginous sediments with dropstones and higher TiO2 and Al2O3 due to enhanced terrigenous sedimentary input. [1] Hoffman et al. (1996) Communs Geol. Surv. Namibia 11, 47-52. [2] Schoenberg et al. (2008) Chemical Geology 249, 294-306. [3] Døssing et al. (2011) Chemical Geology 285, 157-166.

  17. Predictions for ASKAP neutral hydrogen surveys

    NASA Astrophysics Data System (ADS)

    Duffy, Alan R.; Meyer, Martin J.; Staveley-Smith, Lister; Bernyk, Maksym; Croton, Darren J.; Koribalski, Bärbel S.; Gerstmann, Derek; Westerlund, Stefan

    2012-11-01

    The Australian Square Kilometre Array Pathfinder (ASKAP) will revolutionize our knowledge of gas-rich galaxies in the universe. Here we present predictions for two proposed extragalactic ASKAP neutral hydrogen (H I) emission-line surveys, based on semi-analytic models applied to cosmological N-body simulations. The ASKAP H I All-Sky Survey, known as Widefield ASKAP L-band Legacy All-sky Blind surveY (WALLABY), is a shallow 3 π survey (z = 0-0.26) which will probe the mass and dynamics of over 6 × 105 galaxies. A much deeper small-area H I survey, called Deep Investigation of Neutral Gas Origins (DINGO), aims to trace the evolution of H I from z = 0 to 0.43, a cosmological volume of 4 × 107 Mpc3, detecting potentially 105 galaxies. The high-sensitivity 30 antenna ASKAP core (diameter ˜2 km) will provide an angular resolution of 30 arcsec (at z = 0). Our simulations show that the majority of galaxies detected in WALLABY (87.5 per cent) will be resolved. About 5000 galaxies will be well resolved, i.e. more than five beams (2.5 arcmin) across the major axis, enabling kinematic studies of their gaseous discs. This number would rise to 1.6 × 105 galaxies if all 36 ASKAP antennas could be used; the additional six antennas provide baselines up to 6 km, resulting in an angular resolution of 10 arcsec. For DINGO this increased resolution is highly desirable to minimize source confusion, reducing confusion rates from a maximum of 10 per cent of sources at the survey edge to 3 per cent. We estimate that the sources detected by WALLABY and DINGO will span four orders of magnitude in total halo mass (from 1011 to 1015 M⊙) and nearly seven orders of magnitude in stellar mass (from 105 to 1012 M⊙), allowing us to investigate the process of galaxy formation across the last four billion years.

  18. Low-accommodation detrital apron alongside a basement uplift, Pennsylvanian of Midcontinent North America

    NASA Astrophysics Data System (ADS)

    Joeckel, R. M.; Nicklen, B. L.; Carlson, M. P.

    2007-04-01

    The northern end of the 650-km-long Nemaha Uplift (Nebraska and Kansas, USA) is an important example of basin-margin sedimentation in the North American Midcontinent. An apron of coarse, basal Pennsylvanian arkosic clastic sediments (BPC) was deposited on the flanks of the uplift while marine cyclothems were encroaching from the east. Small-scale fining-upward intervals, many with demonstrably erosional bases, dominate the BPC and are interpreted as overridingly fluvial in origin. Weak paleosols, desiccation cracks, and reddened intervals in the BPC record episodic subaerial exposure. Multiple, burrowed horizons and heterolithic strata of probable tidal origin and rare marine fossils also indicate episodic marine influence. The BPC appear to have been deposited as a thin apron of coalesced, alluvial fans and fan deltas. Deposition of the BPC occurred during the waning of uplift and subsequent quiescence. The comparative thinness and large-scale packaging of the BPC are compatible with the controlling effects of relict relief, regional subsidence, and eustasy, rather than ongoing, major vertical displacements along active faults. A strong autocyclic influence on sedimentation is evidenced by stacked fining-upward intervals of poorly-sorted conglomerates, sandstones, and sandy mudstones. Correlations demonstrate that the accumulation of the BPC took place over more than seven major sea-level cycles, beginning in Cherokee Group times (middle Moscovian/middle Pennsylvanian) and ending only when the eroded uplift was inundated and buried by marine cyclothems. On the basis of local correlations with marine cyclothems, and using black phosphatic shales (so-called "core shales" of Heckel, P.H., 1986. Sea-level surve for Pennsylvanian eustatic marine transgressive-regressive depositional cycles along Midcontinent outcrop belt, North America: Geology 14, 330-334., Heckel, P.H., 1994. Evaluation of evidence for glacio-eustatic control over marine Pennsylvanian cyclothems in

  19. Revisiting Baarda's concept of minimal detectable bias with regard to outlier identifiability

    NASA Astrophysics Data System (ADS)

    Prószyński, W.

    2015-10-01

    The concept of minimal detectable bias (MDB) as initiated by Baarda (Publ Geod New Ser 2(5), 1968) and later developed by Wang and Chen (Acta Geodaet et Cartograph Sin Engl Edn 42-51, 1994), Schaffrin (J Eng Surv 123:126-137, 1997), Teunissen (IEEE Aerosp Electron Syst Mag 5(7):35-41, 1990, J Geod 72:236-244 1998, Testing theory: an introduction. Delft University Press, Delft, 2000) and others, refers to the issue of outlier detectability. A supplementation of the concept is proposed for the case of correlated observations contaminated with a single gross error. The supplementation consists mainly of an outlier identifiability index assigned to each individual observation in a network and a mis-identifiability index being the maximum probability of identifying a wrong observation. To those indices there can also be added the MDB multiplying factor to increase the identifiability index to a satisfactory level. As auxiliary measures there are indices of partial identifiability concerning pairs of observations. The indices were derived assuming the generalized outlier identification procedure as in Knight et al. (J Geod. doi: 10.1007/s00190-010-0392-4, 2010), which with one outlier case being assumed is similar to Baarda's w-test (Baarda in Publ Geod New Ser 2(5), 1968). The following two options of identifiability indices and partial identifiability indices are distinguished: I. the indices related to identification of a contaminated observation within a set of observations suspected of containing a gross error (identifiability), II. the indices related to identification of a contaminated observation within a whole set of observations (pseudo-identifiability). To characterize the proposed approach in the context of the existing solutions of similar topic being the separability testing, the properties of both types of identifiability indices are discussed with reference to the concept of Minimal Separable Bias (Wang and Knight in J Glob Position Syst 11(1):46-57, 2012

  20. Constraints on the hydrology of the unsaturated zone at Yucca Mountain, NV from three-dimensional models of chloride and strontium geochemistry

    NASA Astrophysics Data System (ADS)

    Sonnenthal, Eric L.; Bodvarsson, Gudmundur S.

    1999-05-01

    Three-dimensional (3-D) simulations of the spatial and temporal variations in chloride and strontium concentrations in porewaters were performed to constrain infiltration rates, flow paths, and mixing processes in the unsaturated zone (UZ) at Yucca Mountain, NV. Chloride concentrations in infiltrating water were calculated from aerial distributions of precipitation and infiltration rates for the current climatic conditions and for the last glacial maximum, combined with effective chloride concentrations in precipitation. Modeled concentrations are roughly similar to measured porewater chloride concentrations from the Paintbrush nonwelded tuffs in the Exploratory Studies Facility (ESF) tunnel and in boreholes suggesting that the mean infiltration rate over the site is unlikely to be higher than the calculated mean infiltration rate for the modern climate (˜5 mm/year; [Flint, A.L., Hevesi, J.A., Flint, L.E., 1996. Conceptual and Numerical Model of Infiltration for the Yucca Mountain Area, Nevada. Milestone 3GU1623M. U.S. Geol. Surv. Water Res. Invest. Rep. U.S. Geological Survey, Denver, CO]). Porewaters from the late Pleistocene (>10 ka) could be present in the Paintbrush bedded tuffs and in the underlying Topopah Spring welded tuffs (TSw), predominately under regions of thick alluvium having little infiltration. However, porewaters at the potential repository level may have a higher proportion of Holocene recharge due to the higher calculated infiltration rate in this region. Dual-permeability simulations show that in low infiltration regions chemical disequilibrium can exist between fracture and matrix porewaters, as a result of the climate change 10,000 years ago. Below the potential repository level, simulations show significant mixing due to lateral flow on top of the low permeability basal vitrophyre in the Topopah Spring unit and on zeolitized tuffs in the Calico Hills unit. Perched water chloride concentrations are closely matched using the calculated

  1. Crater size distributions on Ganymede and Callisto: fundamental issues

    NASA Astrophysics Data System (ADS)

    Wagner, Roland; Schmedemann, Nico; Werner, Stefanie; Ivanov, Boris; Stephan, Katrin; Jaumann, Ralf

    2015-04-01

    Crater size distributions on the two largest Jovian satellites Ganymede and Callisto and the origin of impactors are subject of intense and controversial debates. In this paper, we reinvestigate crater size distributions measured in surface units derived from a recently published global geologic map, based on Voyager and Galileo SSI images at a scale of 1 km/pxl (Collins G. C. et al. (2013), U. S. Geol. Surv., Sci. Inv. Map 3237). These units are used as a context to units mapped in more detail at higher resolution in Galileo SSI images. We focus on the following fundamental issues: (1) Similarity between shapes of crater distributions on the Galilean satellites and on inner solar system bodies; (2) production versus equilibrium distributions; (3) apex/antapex variations in crater distributions. First, our results show a strong similarity in shape between the crater distributions on the most densely cratered regions on Ganymede and Callisto with those in the lunar highlands. We conclude that the shape of the crater distributions on these two Jovian satellites implies the craters were preferentially formed from members of a collisionally evolved projectile family, derived either from Main Belt asteroids as candidates of impactors on the Jovian satellites, or from projectiles stemming from the outer solar system which have undergone collisional evolution, resulting in a size distribution similar to those of Main Belt asteroids. Second, the complex shape of the crater distributions on Ganymede and Callisto indicates they are mostly production distributions and can be used to infer the underlying shape of the projectile size distribution. Locally, equilibrium distributions occur, especially at smaller sub-kilometer diameters. Third, the most densely cratered regions on both satellites do not show apex-antapex variations in crater frequency, as inferred for bodies from heliocentric orbits (e.g., Zahnle K. et al. (2003), Icarus 163, 263-289). This indicates that these

  2. Mathematical modeling of slope flows with entrainment as flows of non-Newtonian fluids

    NASA Astrophysics Data System (ADS)

    Zayko, Julia; Eglit, Margarita

    2015-04-01

    Non-Newtonian fluids in which the shear stresses are nonlinear functions of the shear strain rates are used to model slope flows such as snow avalanches, mudflows, debris flows. The entrainment of bottom material is included into the model basing on the assumption that in entraining flows the bed friction is equal to the shear stress of the bottom material (Issler et al, 2011). Unsteady motion down long homogeneous slopes with constant inclines is studied numerically for different flow rheologies and different slope angles. Variation of the velocity profile, increase of the flow depth and velocity due to entrainment as well as the value of the entrainment rate is calculated. Asymptotic formulae for the entrainment rate are derived for unsteady flows of different rheological properties. REFERENCES Chowdhury M., Testik F., 2011. Laboratory testing of mathematical models for high-concentration fluid mud turbidity currents. Ocean Engineering 38, 256-270. Eglit, M.E., Demidov, K.S., 2005. Mathematical modeling of snow entrainment in avalanche motion. Cold Reg. Sci. Technol. 43 (1-2), 10-23. Eglit M. E., Yakubenko A. E., 2012, Mathematical Modeling of slope flows entraining bottom material. Eglit M. E., Yakubenko A. E., 2014, Numerical modeling of slope flows entraining bottom material. Cold Reg. Sci. Technol. 108, 139-148. Issler D, M. Pastor Peréz. 2011. Interplay of entrainment and rheology in snow avalanches; a numerical study. Annals of Glaciology, 52(58), pp.143-147 Kern M. A., Tiefenbacher F., McElwaine J., N., 2004. The rheology of snow in large chute flows. Cold Regions Science and Technology, 39, 181 -192. Naaim, M., Faug, T., Naaim-Bouvet, F., 2003. Dry granular flow modelling including erosion and deposition. Surv. Geophys. 24, 569-585. Naaim, M., Naaim-Bouvet, F., Faug, T., Bouchet, A., 2004. Dense snow avalanche modeling: flow, erosion, deposition and obstacle effects. Cold Reg. Sci. Technol. 39, 193-204. Rougier, J & Kern, M 2010, 'Predicting snow

  3. Le POSSUM: un bon score pour prédire la mortalité du sujet âgé opéré en urgence?

    PubMed Central

    Mzoughi, Zeineb; Bayar, Rached; Djebbi, Achref; Talbi, Ghofrane; Romdhane, Hayfa; Aloui, Wafa; Lassaad, Gharbi; Khalfallah, Mohamed Taher

    2016-01-01

    Introduction Le POSSUM (Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity) est un score prédictif de mortalité qui est largement utilisé en chirurgie aortique élective et abdominale. Le but de notre étude est une validation du POSSUM chez le sujet âgé (>70 ans) opéré pour une urgence digestive. Nous nous proposons d'étudier les meilleurs seuils du POSSUM, composé d'un score physiologique et d'un score opératoire, pour prédire la mortalité dans cette population. Méthodes Il s'agit d'une étude rétrospective analytique de type cas témoin à partir d'une série de 291 patients d'âge ≥ 70 ans opérés pour une urgence digestive. Ces patients étaient répartis en deux groupes comportant 50 patients chacun. Le groupe "DC": patients décédés en post opératoire immédiat et le Groupe témoin "SURV" choisis par tirage au sort. Nous avons analysé la fiabilité du POSSUM pour prédire la mortalité et la morbidité. Par la suite, nous avons établi des courbes de ROC pour définir les seuils qui donnent le meilleur couple sensibilité/spécificité. Résultats Le score physiologique, le score opératoire et les taux de morbidité et mortalité prédits par POSSUM et la mortalité prédit par P-POSSUM représentaient des facteurs prédictifs de mortalité (P <0,0001). Les valeurs seuils du score physiologique et du score opératoire qui donnent le meilleur couple sensibilité/spécificité, étaient respectivement de 23 et 15. Conclusion Prédire la mortalité permet de cibler la prise en charge et d'informer le patient et sa famille des risques encourus. PMID:27795763

  4. Cost-effectiveness of eplerenone in NYHA class II chronic heart failure patients with reduced LVEF: an analysis for Greece

    PubMed Central

    Athanasakis, Kostas; Bilitou, Aikaterini; Lee, Dawn; Karampli, Eleftheria; Karavidas, Apostolos; Parissis, John; Sykara, Georgia; Kyriopoulos, John

    2016-01-01

    Objectives The aim of the study was to evaluate the cost-effectiveness (CE) of treatment with eplerenone versus standard care in adult patients with New York Heart Association class II chronic heart failure and reduced left ventricular ejection fraction from the perspective of the Greek national health care payer. Methods A discrete-event model simulating the clinical course and respective outcomes of eplerenone as an add-on to standard therapy versus standard therapy alone based on the pivotal Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF) trial was locally adapted for the Greek setting. Data on medications followed the resource use from eplerenone in mild patients hospitalization and survival study in heart failure and were estimated on a lifetime basis (or until discontinuation). Cost calculations were based on year 2014, event costs (cardiovascular hospitalizations, adverse events, and devices) were sourced from published diagnosis-related groups. A 3% discount rate was applied. In order to test the robustness of the model projections, a range of deterministic and probabilistic sensitivity analyses were carried out. Results Over a patient’s lifetime, the addition of eplerenone to standard care compared to standard care alone led to an incremental gain of 1.33 quality-adjusted life-years (QALYs) (6.53 vs 5.20 QALYs, respectively) as well as an increase in the cost of treatment by €2,160; these outcomes produced an incremental CE ratio of €1,624/QALY for the Greek setting. On the basis of probabilistic sensitivity analysis, there was a 100% likelihood of eplerenone being cost-effective versus standard care at a threshold of €3,500/QALY. Conclusion This analysis indicates that eplerenone may be a cost-effective option versus standard care accompanied by additional clinical benefits and an added incremental cost at an acceptable, if not low, CE ratio. The results are consistent with the previously published

  5. Epidemiology of reported Yersinia enterocolitica infections in Germany, 2001-2008

    PubMed Central

    2010-01-01

    Background Yersiniosis is the third most common zoonotic bacterial disease in Germany and the European Union. Sequelae of Yersinia enterocolitica infections, such as reactive arthritis, have been reported. Consumption of pork and its products, especially eaten raw or undercooked, is an important risk factor of yersiniosis. Infection with Y. enterocolitica is notifiable through the national surveillance system for infectious diseases in Germany and several thousands of cases are being reported each year. We present recent data on the epidemiology of reported yersiniosis in Germany. Methods Surveillance data on yersiniosis, accessed through the national level database (SurvNet), were analyzed with regard to time trends, demographical and geographical distribution, serotypes, and hospitalization, for the time period 2001-2008. Results A total of 47,627 cases of yersiniosis were reported. The mean annual incidence of yersiniosis was 7.2/100,000 population. A downward trend in the number of reportable cases has occurred since 2002. Almost all Y. enterocolitica infections were reported as single cases, i.e., with no apparent links to other cases. The number of reported infections showed substantially less seasonal variation than in other zoonotic enteric diseases. The incidence was highest in children under five years (58/100,000 population), in particular in one-year-old children (108/100,000 population). Almost 97% of infections were acquired domestically. High incidences occurred in the eastern German federal states Thuringia, Saxony, and Saxony-Anhalt. Differences in incidences across federal states were driven primarily by incidence differences in children under five years. Hospitalization was reported for 17% of cases, the proportion being highest among teenagers. Almost 90% of Y. enterocolitica strains were diagnosed as serotype O:3, which is the serotype most frequently isolated from pigs. Conclusions Yersiniosis is a zoonotic foodborne disease of relevance to

  6. Cloud Fraction: Can it be Defined and Measured? And if we Knew it Would it be of any use to us?

    NASA Astrophysics Data System (ADS)

    Schwartz, S. E.

    2013-12-01

    several techniques over a 2-day period in May, 2009. ARSCL (Clothiaux, JAM, 2000), is time-average based on vertically pointing lidars and millimeter cloud radars; SIRS (Long, JGR, 2006) is time-average based on downwelling SW irradiance. TSI is based on fraction of cloudy pixels within 50° cone about vertical. GOES is based on average of all pixels (4-km size; satellite) within 20 km of the surface measurement site (Genkova, 14th ARM STM, 2004). Gray denotes nighttime; TSI and SIRS not available. Modified from Stevens and Schwartz (Surv. Geophys., 2012).

  7. Testing earthquake prediction algorithms: Statistically significant advance prediction of the largest earthquakes in the Circum-Pacific, 1992-1997

    USGS Publications Warehouse

    Kossobokov, V.G.; Romashkova, L.L.; Keilis-Borok, V. I.; Healy, J.H.

    1999-01-01

    Algorithms M8 and MSc (i.e., the Mendocino Scenario) were used in a real-time intermediate-term research prediction of the strongest earthquakes in the Circum-Pacific seismic belt. Predictions are made by M8 first. Then, the areas of alarm are reduced by MSc at the cost that some earthquakes are missed in the second approximation of prediction. In 1992-1997, five earthquakes of magnitude 8 and above occurred in the test area: all of them were predicted by M8 and MSc identified correctly the locations of four of them. The space-time volume of the alarms is 36% and 18%, correspondingly, when estimated with a normalized product measure of empirical distribution of epicenters and uniform time. The statistical significance of the achieved results is beyond 99% both for M8 and MSc. For magnitude 7.5 + , 10 out of 19 earthquakes were predicted by M8 in 40% and five were predicted by M8-MSc in 13% of the total volume considered. This implies a significance level of 81% for M8 and 92% for M8-MSc. The lower significance levels might result from a global change in seismic regime in 1993-1996, when the rate of the largest events has doubled and all of them become exclusively normal or reversed faults. The predictions are fully reproducible; the algorithms M8 and MSc in complete formal definitions were published before we started our experiment [Keilis-Borok, V.I., Kossobokov, V.G., 1990. Premonitory activation of seismic flow: Algorithm M8, Phys. Earth and Planet. Inter. 61, 73-83; Kossobokov, V.G., Keilis-Borok, V.I., Smith, S.W., 1990. Localization of intermediate-term earthquake prediction, J. Geophys. Res., 95, 19763-19772; Healy, J.H., Kossobokov, V.G., Dewey, J.W., 1992. A test to evaluate the earthquake prediction algorithm, M8. U.S. Geol. Surv. OFR 92-401]. M8 is available from the IASPEI Software Library [Healy, J.H., Keilis-Borok, V.I., Lee, W.H.K. (Eds.), 1997. Algorithms for Earthquake Statistics and Prediction, Vol. 6. IASPEI Software Library]. ?? 1999 Elsevier

  8. Can we use only Grain Size Data for Paleo-Flow Reconstructions?

    NASA Astrophysics Data System (ADS)

    Perillo, M. M.; Pohl, F.; Eggenhuisen, J. T.; Fedele, J.; Hoyal, D. C. J. D.; Mohrig, D. C.

    2015-12-01

    velocity, and whether this inverted shear velocity is in accordance with the experimental flow conditions. Preliminary application of this method to outcrop work will be given. Bagnold, R. (1966), U. S. Geol. Surv. Prof. Pap., 422-I, 37 pp. Eastwood, E. N., G. Kocurek, D. Mohrig, and T. Swanson (2012), J. Geophys. Res., 117, F03035, doi:10.1029/2012JF002368.

  9. Comparing the topographic long profiles of gullies on Earth and Mars

    NASA Astrophysics Data System (ADS)

    Conway, Susan; Balme, Matthew; Murray, John; Towner, Martin

    2014-05-01

    Planet. Sci. Conf. 35, (2004),no. 1556. [6] C.H. Hugenholtz, Icarus, (2008), 197,65-72. [7] J.L. Dickson and J.W. Head, Icarus, (2009), 204,63-86. [8] C.J. Gallagher and M.R. Balme, Geol. Soc. Lond. Spec. Publ., (2011), 356,87-110. [9] J.T. Hack, US Geol. Surv. Prof. Pap., (1957), 294-B,45-97. [10] M.A. Kreslavsky, Workshop Martian Gullies, (2008),abs.#1301.

  10. Aeolian processes and dune morphology in the Gobi and Badain Jaran Desert using LandSat Imagery.

    NASA Astrophysics Data System (ADS)

    Cardinale, Marco; Cannito, Arturo; Marinangeli, Lucia

    2014-05-01

    Global Sand Sea. (1979) [2] Yang, X. Chinese Science Bulletin 46, 6-11, (2000). [3] Yang, X., et al. Quaternary International 104 ( 2003). 99-112. [4] NASA Landsat Program (2003) Landsat ETM+scene, p129r031_7t20000713, SLC-Off, USGS, Sioux Falls, 10/26/2003. [5] Tachikawa, T., et al. The characteristics of ASTER GDEM version 2, IGARSS, July 2011. [6] McKee E. D. (1979) U.S.Geol. Surv.Prof. Pap., 1052, 3-17. [7] Werner, B.T. 1995. Eolian dunes: Computer simulations and attractor interpretation. Geology 23: 1107-1110.

  11. U-Pb ID-TIMS zircon ages of TTG gneisses of the Aravalli Craton of India

    NASA Astrophysics Data System (ADS)

    Chauhan, Hiredya; Saikia, Ashima; Kaulina, Tatiana; Bayanova, Tamara; Ahmad, Talat

    2015-04-01

    zircon types from UD-16 sample yield a U-Pb discordant age of 2680±30 Ma. Two zircon fractions from UD-17 sample show discordant 207Pb/206Pb ages of 2506 and 2577 Ma. Zircons in our samples have moderate to high U contents (180-770 ppm) with low Th/U ratios (0.2-0.5) in the sample UD-16, characteristic for magmatic zircons from TTG rocks. Thus the obtained age of 2680±30 Ma is interpreted as an age of magmatic crystallization of tonalites. Gopalan, K. et al., (1990): Precambrian Res., 48, 287-297. Ludwig, K.R. (1991): PBDAT program. US. Geol. Surv. Open-file report 88-542, 38 p. Ludwig, K. R. (2008): Isoplot/Ex, version 3.6, Berkeley Geochronology Center, Special Publication no. 4. Upadhyaya, R. et al., (1992): Current Sci., 62(2): 87-92. Wiedenbeck, M. et al., (1996): Chem Geol. 129: 325-340.

  12. Copernican tectonic activities in the northwestern Imbrium region of the Moon

    NASA Astrophysics Data System (ADS)

    Daket, Yuko; Yamaji, Atsushi; Sato, Katsushi

    2015-04-01

    area lasted until recently. Those young tectonic activities are too young to be explained by mascon loading hypothesis. Tectonism induced by global cooling or orbital evolution are possible origins for the young horizontal compression. However, they cannot explain the recent extension. Our study area is located in PKT region where the heat-producing elements are more abundant than surrounding areas. Therefore, regional cooling would be a reasonable explanation for the young extensional tectonics. References Ono, T., A. Kumamoto, H. Nakagawa, Y. Yamaguchi, S. Oshigami, A. Yamaji, T. Kobayashi, Y. Kasahara, and H. Oya, 2009, Science, 323, 909--912. Solomon, S.C. and Head, J.W., 1980, Rev. Geophys., 18, 107--141. Trask, N.J., 1971, Geological Survey Research, U.S. Geol. Surv. Prof. Pap. 750-D, D138--D144. Watters, T.R., M.S. Robinson, M.E. Banks, T. Tran, and B.W. Denevi, 2012, Nature Geosci., 5, 181--185.

  13. Mont Terri Underground Rock Laboratory, Switzerland-Research Program And Key Results

    NASA Astrophysics Data System (ADS)

    Nussbaum, C. O.; Bossart, P. J.

    2012-12-01

    scenarios and v) Evaluation of diffusion and retention parameters for long-lived radionuclides. Experiments related to repository-induced perturbations are focused on: i) Influence of rock liner on the disposal system and the buffering potential of the host rock; ii) Self-sealing processes in the excavation damaged zone; iii) Hydro-mechanical coupled processes (e.g. stress redistributions and pore pressure evolution during excavation); iv) Thermo-hydro-mechanical-chemical coupled processes (e.g. heating of bentonite and host rock) and v) Gas-induced transport of radionuclides in porewater and along interfaces in the engineered barrier system. A third research direction is to demonstrate the feasibility of repository construction and long-term safety after repository closure. Demonstration experiments can contribute to improving the reliability of the scientific basis for the safety assessment of future geological repositories, particularly if they are performed on a large scale and with a long duration. These experiments include the construction and installation of engineered barriers on a 1:1 scale: i) Horizontal emplacement of canisters; ii) Evaluation of the corrosion of container materials; repository re-saturation; iii) Sealing of boreholes and repository access tunnels and iv) Long-term monitoring of the repository. References Bossart, P. & Thury, M. (2008): Mont Terri Rock Laboratory. Project, Programme 1996 to 2007 and Results. - Rep. Swiss Geol. Surv. 3.

  14. P and S automatic picks for 3D earthquake tomography in NE Italy

    NASA Astrophysics Data System (ADS)

    Lovisa, L.; Bragato, P.; Gentili, S.

    2006-12-01

    quantity of recordings must by quickly analyzed to provide some preliminary results (e.g., to decide about further data acquisition when using temporary networks) or when a sort of "real-time tomography" is required (e.g., continuous imaging of volcanoes during their activity). References Evans J.R., Eberhart-Phillips D., and Thurber C.H. (1994). User's manual for simulps12 for imaging vp and vp/vs: a derivative of the Thurber tomographic inversion simul3 for local earthquakes locations and explosions, U.S.Geol. Surv. Open File Report, 7 pp. Gentile, G. F., Bressan, G., Burlini, L., De Franco, R., 2000, Three - dimensional Vp and Vp/Vs models of the upper crust in the Friuli area (Northeastern Italy)., Geophys. Journ. Int., 141, 457-478. Gentili S. and Bragato P. L., 2006,"A neural-tree-based system for automatic location of earthquakes in Northeastern Italy" Journal of Seismology, Volume 10, Number 1, pp.73-89. Michelini, A., Mcevilly, T. V., 1991, "Seismological studies at Parkfield; I, Simultaneous inversion for velocity structure and hypocenters using cubic B-splines parameterization.", Bulletin of the Seismological Society of America, 81, 2, 524-552.

  15. Multidisciplinary management of invasive placenta previa.

    PubMed

    Walker, Melissa G; Allen, Lisa; Windrim, Rory C; Kachura, John; Pollard, Lindsay; Pantazi, Sophia; Keating, Sarah; Carvalho, Jose C A; Kingdom, John C P

    2013-05-01

    sultats : Les 33 participantes ont survécu au cours de cette période. Les deux tiers (22/33) d’entre elles présentaient cinq ou six des six composantes des soins multidisciplinaires. L’utilisation croissante des composantes des soins multidisciplinaires a été associée à une baisse significative de la morbidité composite (R2 = 0,228, P = 0,005). Conclusion : L’évaluation et la prise en charge en équipe des femmes qui présentent un placenta prævia invasif sont susceptibles d’améliorer les issues maternelles et devraient être favorisées sur une base régionale.

  16. Asteroid mega-impacts and Precambrian banded iron formations: 2.63 Ga and 2.56 Ga impact ejecta/fallout at the base of BIF/argillite units, Hamersley Basin, Pilbara Craton, Western Australia

    NASA Astrophysics Data System (ADS)

    Glikson, Andrew; Vickers, John

    2007-02-01

    Australia. Aust. J. Earth Sci. 51 (2004) 621-644.]) and lies directly below a thin volcanic tuff (2629 ± 5 Ma, [A.F. Trendall, W. Compston, D.R. Nelson, J.R. deLaeter, V.C. Bennett, SHRIMP zircon ages constraining the depositional chronology of the Hamersley Group, Western Australia. Aust. J. Earth Sci. 51 (2004) 621-644.]) and banded iron formation (BIF) (upper part of Marra Mamba Iron Formation, 2597 ± 5 Ma [A.F. Trendall, W. Compston, D.R. Nelson, J.R. deLaeter, V.C. Bennett, SHRIMP zircon ages constraining the depositional chronology of the Hamersley Group, Western Australia. Aust. J. Earth Sci. 51 (2004) 621-644.]). The Spherule Marker Bed (SMB) [B.M. Simonson, Geological evidence for an early Precambrian microtektite strewn field in the Hamersley Basin of Western Australia. Geol. Soc. Am. Bull. 104 (1992) 829-839; B.M. Simonson, S.W. Hassler, K.A. Schubel, Lithology and proposed revisions in stratigraphic nomenclature of the Wittenoom Formation (Dolomite) and overlying formations, Hamersley Group, Western Australia. Geol. Surv. W. Aust. Rep. 345 (1993) 65-79; S.W. Hassler, B.M. Simonson, D.Y. Sumner, D. Murphy, Neoarchaean impact spherule layers in the Fortescue and Hamersley Groups, Western Australia: stratigraphic and depositional implications of re-correlation. Aust. J. Earth Sci. 52 (2005) 759-772. [5

  17. Variations in Pb concentrations and Pb-isotope ratios in soils collected along an east-west transect across the United States

    NASA Astrophysics Data System (ADS)

    Smith, David; Woodruff, Laurel; Reimann, Clemens; Flem, Belinda

    2014-05-01

    feldspar content for the same 2500-km portion of the transect from east-central Colorado to the Atlantic coast that shows steadily increasing precipitation. No such correlation exists in the soil C horizon. The data demonstrate the importance of climate and weathering on both Pb concentration and 206Pb/207Pb isotope ratios in soil samples and natural shifts thereof in the soil profile during soil-forming processes. The results of this study demonstrate that often none of above two requirements for the use of Pb isotopes in environmental sciences will be met. REFERENCES Smith, D.B., Cannon, W.F., Woodruff, L.G., Garrett, R.G., Klassen, R., Kilburn, J.E., Horton, J.D., King, H.D., Goldhaber, M.B., Morrison, J.M., 2005. Major- and trace-element concentrations in soils from two continental-scale transects of the United States and Canada. U.S. Geol. Surv. Open-File Rep. 2005-1253.

  18. The implications of Chang'e-3 VIS/NIR Imaging Spectrometer in-situ analysis data

    NASA Astrophysics Data System (ADS)

    Yao, Meijuan; Zhang, Hongbo; Su, Yan; Liu, Bin; Zhao, Shu; Xue, Xiping

    2015-04-01

    believe that at least the identification of the minerals gives us valuable imformation about the landing site. References: [1] Liu B. (2014). RAA, 14, 1578-1594. [2] Thiessen F. et al., (2014). Planetary and Space Science, 104, 244-252. [3]Yamamoto S. et al., (2010). Nat. Geosci. 3, 533-536. [4] Tong S. et al,. (2013). Icarus 222, 401-410. [5] Wilhelm D.E., and McCauley J.F. (1971). 1-703. U.S. Geol. Surv., Washington D.C. [6] Li C.L. et al., (2014). RAA, 14, 1514-1529. Acknowledgements: This work was supported by the CHANG'E-3 funding from Chinese Lunar Exploration Program, undertaken by the China National Space Administration (CNSA). This work is also supported by the NSFC program (41490633).

  19. Depth Dependence of the Fault Strength in the Creeping Section of the Atotsugawa Fault, Japan

    NASA Astrophysics Data System (ADS)

    Mizoguchi, K.; Fukuyama, E.; Kitamura, K.; Takahashi, M.; Masuda, K.

    2005-12-01

    The Atotsugawa fault is located along a highly deformed region in central Japan with 60km long, striking to N60°E and dipping to 90° ± 10°. From the laser distance measurement survey, a creeping section (1.5mm/y) was found in the northeastern part [Geogr. Surv. Inst., 1997]. In this section, a low seismicity area down to a depth of 7km was found above the seismically active region down to 15 km [Ito and Wada, 1999]. In order to investigate the depth dependent feature of the fault strength, we conducted tri-axial friction tests of the Atotsugawa fault gouge under the conditions of 1, 3, 5 and 7km depth. The NIED drilled a borehole in the fault zone down to a depth of 350m in this creeping section [Omura et al., 2004] and obtained core samples consisting of fault gouge, fault breccia and fractured host rocks (granitic rocks and hornblende gneiss). The samples are taken in the gouge zone (8.5mm in thickness) located at a depth of 342 m. The samples were disaggregated in distilled water and passed through a 100μm diameter sieve for the friction tests. From the XRD analysis, the gouge sample consists of quartz, feldspar, smectite, kaolinite and micas. The average grain size in the sample was approximately 16.9μm measured by a laser diffraction particle size analyzer. The friction tests were run using a gas-medium tri-axial apparatus at the AIST, Japan [Masuda et al., 2002]. For each run, 0.5g gouge powder was put between 30° sawcut of an alumina ceramic cylinder (20mm in diameter) and sheared at a constant axial slip rate of 0.1μm/s. Each test was done with pore fluid of distilled water at the temperature-pressure conditions of 1-7 km depths assuming a hydrostatic pore-pressure gradient of 10MPa/km, a lithostatic confining pressure gradient of 26MPa/km and a geothermal gradient of 30°C/km. In all experiments, the friction increases rapidly to an axial displacement of about 0.1mm, and then it gradually increases or becomes steady state. We found a strong depth

  20. Calorimetric Thermometry of Meteoritic Troilite: Early Reconnaissance

    NASA Astrophysics Data System (ADS)

    Allton, J. H.; Wentworth, S. J.; Gooding, J. L.

    1993-07-01

    are the consequence of different thermal histories. Multiple samples of Del Norte troilite were used to determine the influence of laboratory-scale thermal histories on DSC signatures by heating and cooling each sample under different programmed conditions. In reconnaissance experiments, maximum temperature achieved during heat treatment appears to be more influential than does either the time maintained at temperature or the heating/cooling rate. The experimentally measured alpha/beta onset temperature shows a systematic decline with maximum temperature achieved during prior heating, suggesting that high onset temperatures are indicative of low maximum temperatures in the natural histories of the troilite samples. That trend is at least qualitatively consistent with the petrologic rankings of the meteorites in which troilite from the relatively unmetamorphosed L3 chondrite shows a higher onset temperature than does troilite from either the highly metamorphosed L7 chondrite or the octahedrite. Additional work should define the limits of a quantitative calibration that might ultimately permit derivation of meteorite thermal histories by calorimetric thermometry of troilite. Samples were kindly provided by E. R. D. Scott (Mundrabilla), C. B. Moore (Del Norte), and the Meteorite Working Group (PAT91501; EET83213 powder from E. Jarosewich). References: [1] Chase M. W. Jr. et al. (1985) JANAF Thermochemical Tables, 3rd ed., 1194. [2] Robie R. A. et al. (1979) Geol. Surv. Bull. 1452, 125. [3] Allton J. H. and Gooding J. L. (1993) LPS XXIV, 21-22. Fig. 1, which appears here in the hard copy, shows the thermodynamics of troilite alpha/beta phase transformations measured by DSC during first-heat cycles.

  1. X-Ray Data on Extraterrestrial CA Dialuminate (CaAl4O7)

    NASA Astrophysics Data System (ADS)

    Weber, D.; Ross, C. R., II; Bischoff, A.

    1993-07-01

    volume, are slightly higher in Ca-dialuminate from Acfer 182 than from synthetic CaAl4O7. This may be due to the incorporation of traces of refractory elements (REE) with large ionic radii, which were analyzed within inclusion 022/9 [10]. With the determination of the cell constants of natural Ca-dialuminate combined with data on synthetic CaAl4O7, sufficient X-ray data should be available required to nominate this mineral. References: [1] Christophe Michel-Levy M. et al. (1982) EPSL, 61, 13-22. [2] Kimura M. et al. (1993) GCA, in press. [3] Weber D. and Bischoff A. (1992) Meteoritics, 27, 304-305. [4] Weber D. and Bischoff A. (1993) GCA, submitted. [5] Boyko E. R. and Wisnyi L. G. (1958) Acta Cryst., 11, 444-445. [6] Goodwin D. W. and Lindop A. J. (1970) Acta Cryst., B26, 1230-1235. [7] Baldock P. J. et al. (1970) J. Appl. Cryst., 3, 188-191. [8] Geiger C. A. et al. (1988) GCA, 52, 1729-1736. [9] Gross S. (1977) Geol. Surv. Israel Bull. 70, 1-80. [10] Bischoff A. et al. (1992) Meteoritics, 27, 204. Table 1, which appears in the hard copy, shows unit-cell constants of Ca- dialuminate (monocline; space group C2/c) and X-ray powder diffraction data (CrK-alpha (Ni-beta), 45 kV, 30 mA) on extraterrestrial CaAl4O7 in comparison to JCPDS data [7]. Numbers in parentheses are uncertainties in last significant figures.

  2. Slope control on the aspect ratio of river basins

    NASA Astrophysics Data System (ADS)

    Castelltort, S.; Simpson, G.; Darrioulat, A.

    2009-04-01

    which a river basin acquired its geometry based solely on a measure of its basin form. This relation provides a unique means of inferring the relative chronology of river basin development with respect to surface tilting and therefore provides a direct link between river basin morphology and tectonics. Instead of viewing river basins as largely invariant, this work highlights the differences between basins that bear important information about tectonics and climate. 1.P. S. Dodds, D. H. Rothman, Ann. Rev. Earth Planet. Sci. 28, 571 (2000). 2.J. T. Hack, US Geol. Surv. Prof. Pap. 294-B, (1957). 3.R. E. Horton, Geol. Soc. Am. Bull. 56, 275 (1945). 4.J. W. Kirchner, Geology 21, 591 (1993). 5.I. Rodriguez-Iturbe, A. Rinaldo, Fractal river basins: chance and self-organization. (1997). 6.D. R. Montgomery, W. E. Dietrich, Science 255, 826 (1992). 7.N. Hovius, Basin Res. 8, 29 (1996). 8.R. S. Parker, Hydrology Papers, Colorado State University 90, 58 (1977). 9.J. D. Pelletier, Geomorphology 53, 183 (2003). 10.Schumm, The Fluvial System. (John Wiley & Sons, New York, 1977), pp. 338. 11.G. D. H. Simpson, F. Schlunegger, J. Geophys. Res 108, 2300 (2003). 12.N. Schorghofer, D. H. Rothman, Geophys. Res. Lett. 29, 1633 (2002).

  3. GIS-based landslide hazard evaluation at the regional scale: some critical points in the permanent displacement approach for seismically-induced landslide maps

    NASA Astrophysics Data System (ADS)

    Vessia, Giovanna; Parise, Mario

    2013-04-01

    local practitioners. Seismically-induced landslide hazard maps have been drawn using the aforementioned three expressions. The preliminary results show Quaternary deposits (including alluvium deposits, slope wash, and terrace deposits) as the lithologies most affected by permanent displacement. Moreover, Towsley and Modelo formations, that are stiffer than the previous rock units, and consist mostly of shales, siltstones and subordinate sandstones, show high hazard value where the slopes increase. The relevant role of local slope in permanent displacement extent is evident where lithologies are characterized by both cohesive and frictional resistance components. Finally, a comparison among the maps produced by using the three expressions for permanent displacements is discussed. References Ambraseys N.N. and Menu J.M. (1988) Earthquake-induced ground displacements. Earthquake Engineering and Structural Dynamics, 16: 985-1006. Harp E.L. and Jibson R.W. (1995) Inventory of landslides triggered by the 1994 Northridge, California earthquake. US Geol. Surv. Open-File Rep. 95-213 17 pp. Jibson R. (2007) Regression models for estimating coseismic landslide displacement. Engineering Geology, 91: 209-218. Luzi L. and Pergalani F. (2000) A correlation between slope failures and accelerometric parameters: the 26 September 1997 earthquake (Umbria-Marche, Italy). Soil Dynamics and Earthquake Engineering, 20: 301-313. Newmark N.M. (1965) Effects of earthquakes on dams and embankments. Geotechnique 965, 15(2): 139-160. Parise M. and Jibson R.W. (2000) A seismic landslide susceptibility rating of geologic units based on analysis of characteristics of landslides triggered by the 17 January, 1994 Northridge, California earthquake. Engineering Geology, 58: 251-270. Romeo R. (2000) Seismically induced landslide displacements: a predictive model. Engineering Geology, 58: 337-351.

  4. Lyapunov analysis: from dynamical systems theory to applications

    NASA Astrophysics Data System (ADS)

    Cencini, Massimo; Ginelli, Francesco

    2013-06-01

    . Mon. 82 985 [15] Feigenbaum M J 1978 J. Stat. Phys. 19 25 [16] Oseledets V I 1968 Trans. Moscow Math. Soc. 19 197 [17] Birkhoff G D 1931 Proc. Natl Acad. Sci. USA 17 656 [18] von Neumann J 1932 Proc. Natl Acad. Sci. USA 18 70 [19] Krylov N S 1979 Works on the Foundations of Statistical Physics (Princeton, NJ: Princeton University Press) [20] Anosov D V and Sinai Y G 1967 Russ. Math. Surv. 22 103 [21] Pesin Y B 1976 Sov. Math. Dokl. 17 196 [22] Sinai Y G 1972 Russ. Math. Surv. 27 21 [23] Ruelle D 1979 Publ. Math. l'IHES 50 27 [24] Bowen R 1975 Equilibrium States and the Ergodic Theory of Anosov Diffeomorphisms (Lecture Notes in Mathematics vol 470) (Berlin: Springer) [25] Bowen R and Ruelle D 1975 Invent. Math. 29 181 [26] Shimada I and Nagashima T 1979 Prog. Theor. Phys. 61 1605 [27] Benettin G, Galgani L, Giorgilli A and Strelcyn J M 1980 Meccanica 15 9 [28] Grassberger P and Procaccia I 1984 Physica D 13 34 [29] Wolf A, Swift J B, Swinney H L and Vastano J A 1985 Physica D 16 285 [30] Takens F 1981 Detecting strange attractors in turbulence Dynamical Systems and Turbulence (Lecture Notes in Mathematics vol 898) ed D A Rand and L S Young (Berlin: Springer) p 366 [31] Eckmann J P and Ruelle D 1985 Rev. Mod. Phys. 57 617 [32] Legras B and Vautard R 1996 A guide to Lyapunov vectors Predictability (ECWF Seminar vol 1) ed T Palmer (Reading: ECMWF) p 141 3Prior to their publication in the West at the end of the 1970s, Krylov's results appeared in his PhD dissertation, published posthumously in 1950.

  5. Concentric Crater Fill in Utopia Planitia: Timing and Transitions Between Glacial and Periglacial Processes.

    NASA Astrophysics Data System (ADS)

    Levy, J.; Head, J.

    2008-09-01

    those observed on flowing debris-covered glaciers on Earth [20]. Inversion of polygon topography at polygon margins due to differential sublimation would result in the formation of raised mounds and chains of mounds, some of which may preserve the original surface trough (e.g., the axial furrows observed in some BT mound chains). Deposition of thin layers of low-albedo BTC material on ice-cored FBT mounds could result in enhanced sublimation of residual icecores [21], leading to collapse of FBT mounds, and generating HBT features at contacts between BT and BTC units. References. [1] Squyres, S. (1979) JGR, 84, 8087-8096. [2] Squyres, S. & Carr, M. (1986) Sci., 231, 249-252. [3] Lucchita, B. (1984) JGR, 89, 409-418. [4] Zimbelman, J. et al. (1989) LPSC19, 397-407. [5] Mangold, N. & Allemand, P. (2001) GRL, 28, 3407-3410. [6] Head, J. et al. (2006) GRL, doi: 10.1029/2005GL024360. [7] Levy, J. et al. (2007) JGR, doi: 10.1029/ 2006JE002852. [8] Holt, J. et al. (2008) LPSC39, #2441. [9] Plaut, J. et al. (2008) LPSC39, #1391. [9] Dobrea, N. et al. (2007) 7th Mars, #3358. [10] Levy, J. et al. (2008) LPSC39, #1171, [11] Mangold, N. (2003) JGR, doi:10.1029/2002JE001885. [12] Mustard, J. et al. (2001) Nature, 412, 411-414. [13] Head, J. et al. (2003) Nature, 426, 797-802. [14] Kreslavsky, M. & Head, J. (2006) M&PS, 41, 1633-1646. [15] Marchant, D. et al. (2002), GSAB, 114, 718-730. [16] Milliken, R. et al. (2003) JGR, doi: 10.1029/2002JE002005. [17] Pewe, T. (1959) Am. J. Sci., 257, 545-552. [18] Root, J. (1975) Geol. Surv. Can., 75-1B, 181. [19] Garvin, J. et al. (2002) LPSC33, #1255. [20] Levy, J. et al. (2006) Ant. Sci., doi: 10.1017/ S0954102006000435. [21] Williams, K. et al. (2008) Icarus, In Press.