Inhibition of hydrogen sulfide generation from disposed gypsum drywall using chemical inhibitors.

PubMed

Xu, Qiyong; Townsend, Timothy; Bitton, Gabriel

2011-07-15

Disposal of gypsum drywall in landfills has been demonstrated to elevate hydrogen sulfide (H(2)S) concentrations in landfill gas, a problem with respect to odor, worker safety, and deleterious effect on gas-to-energy systems. Since H(2)S production in landfills results from biological activity, the concept of inhibiting H(2)S production through the application of chemical agents to drywall during disposal was studied. Three possible inhibition agents - sodium molybdate (Na(2)MoO(4)), ferric chloride (FeCl(3)), and hydrated lime (Ca(OH)(2)) - were evaluated using flask and column experiments. All three agents inhibited H(2)S generation, with Na(2)MoO(4) reducing H(2)S generation by interrupting the biological sulfate reduction process and Ca(OH)(2) providing an unfavorable pH for biological growth. Although FeCl(3) was intended to provide an electron acceptor for a competing group of bacteria, the mechanism found responsible for inhibiting H(2)S production in the column experiment was a reduction in pH. Application of both Na(2)MoO(4) and FeCl(3) inhibited H(2)S generation over a long period (over 180 days), but the impact of Ca(OH)(2) decreased with time as the alkalinity it contributed was neutralized by the generated H(2)S. Practical application and potential environmental implications need additional exploration. Copyright © 2011 Elsevier B.V. All rights reserved.

The 16 August 1997 Novaya Zemlya seismic event as viewed from GSN stations KEV and KBS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartse, H.E.

1997-11-01

Using current and historic seismic records from Global Seismic Network stations KEV and KBS, the authors find that S minus P arrival time comparisons between nuclear explosions and the 16 August 1997 seismic event (m{sub b} {approx} 3.6) from near Novaya Zemlya clearly indicate that (relative to KEV) the 16 August event occurred at least 80 km east of the Russian test site. Including S minus P arrival times from KBS constrains the location to beneath the Kara Sea and in good agreement with previously reported locations, over 100 km southeast of the test site. From an analysis of P{submore » n}/S{sub n} waveform ratios at frequencies above 4 Hz, they find that the 16 August event falls within the population of regional earthquakes and is distinctly separated from Novaya Zemlya and other northern Eurasian nuclear explosion populations. Thus, given its location and waveform characteristics, they conclude the 16 August event was an earthquake. The 16 August event was not detected at teleseismic distances, and thus, this event provides a good example of the regional detection, location, and identification efforts that will be required to monitor the Comprehensive Test Ban Treaty below m{sub b} {approx} 4.« less

Geologic and hydrologic considerations for various concepts of high-level radioactive waste disposal in conterminous United States

USGS Publications Warehouse

Ekren, E.B.; Dinwiddie, G.A.; Mytton, J.W.; Thordarson, William; Weir, J.E.; Hinrichs, E.N.; Schroder, L.J.

1974-01-01

The purpose of this investigation is to evaluate and identify which geohydrologic environments in conterminous United States are best suited for various concepts or methods of underground disposal of high-level radioactive wastes and to establish geologic and hydrologic criteria that are pertinent to high-level waste disposal. The unproven methods of disposal include (1) a very deep drill hole (30,000-50,000 ft or 9,140-15,240 m), (2) a matrix of (an array of multiple) drill holes (1,000-20,000 ft or 305-6,100 m), (3) a mined chamber (1,000-10,000 ft or 305-3,050 m), (4) a cavity with separate manmade structures (1,000-10,000 ft or 305-3,050 m), and (5) an exploded cavity (2,000-20,000 ft or 610-6,100 m) o The geohydrologic investigation is made on the presumption that the concepts or methods of disposal are technically feasible. Field and laboratory experiments in the future may demonstrate whether or not any of the methods are practical and safe. All the conclusions drawn are tentative pending experimental confirmation. The investigation focuses principally on the geohydrologic possibilities of several methods of disposal in rocks other than salt. Disposal in mined chambers in salt is currently under field investigation, and this disposal method has been intensely investigated and evaluated by various workers under the sponsorship of the Atomic Energy Commission. Of the various geohydrologic factors that must be considered in the selection of optimum waste-disposal sites, the most important is hydrologic isolation to assure that the wastes will be safely contained within a small radius of the emplacement zone. To achieve this degree of hydrologic isolation, the host rock for the wastes must have very low permeability and the site must be virtually free of faults. In addition, the locality should be in (1) an area of low seismic risk where the possibility of large earthquakes rupturing the emplacement zone is very low, (2) where the possibility- of flooding by

40 CFR 229.3 - Transportation and disposal of vessels.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Transportation and disposal of vessels. 229.3 Section 229.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN... procedures; (iv) Information on the potential effect of the vessel disposal on the marine environment; and (v...

40 CFR 229.3 - Transportation and disposal of vessels.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Transportation and disposal of vessels. 229.3 Section 229.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN... procedures; (iv) Information on the potential effect of the vessel disposal on the marine environment; and (v...

Analysis of nuclear waste disposal in space, phase 3. Volume 2: Technical report

NASA Technical Reports Server (NTRS)

Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

1980-01-01

The options, reference definitions and/or requirements currently envisioned for the total nuclear waste disposal in space mission are summarized. The waste form evaluation and selection process is documented along with the physical characteristics of the iron nickel-base cermet matrix chosen for disposal of commercial and defense wastes. Safety aspects of radioisotope thermal generators, the general purpose heat source, and the Lewis Research Center concept for space disposal are assessed as well as the on-pad catastrophic accident environments for the uprated space shuttle and the heavy lift launch vehicle. The radionuclides that contribute most to long-term risk of terrestrial disposal were determined and the effects of resuspension of fallout particles from an accidental release of waste material were studied. Health effects are considered. Payload breakup and rescue technology are discussed as well as expected requirements for licensing, supporting research and technology, and safety testing.

Analysis of nuclear waste disposal in space, phase 3. Volume 2: Technical report

NASA Astrophysics Data System (ADS)

Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

1980-03-01

The options, reference definitions and/or requirements currently envisioned for the total nuclear waste disposal in space mission are summarized. The waste form evaluation and selection process is documented along with the physical characteristics of the iron nickel-base cermet matrix chosen for disposal of commercial and defense wastes. Safety aspects of radioisotope thermal generators, the general purpose heat source, and the Lewis Research Center concept for space disposal are assessed as well as the on-pad catastrophic accident environments for the uprated space shuttle and the heavy lift launch vehicle. The radionuclides that contribute most to long-term risk of terrestrial disposal were determined and the effects of resuspension of fallout particles from an accidental release of waste material were studied. Health effects are considered. Payload breakup and rescue technology are discussed as well as expected requirements for licensing, supporting research and technology, and safety testing.

78 FR 77171 - Proposed Disposal of George H.W. Bush and Clinton Administration Electronic Backup Tapes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION [NARA-2014-011] Proposed Disposal of George H.W. Bush... George H.W. Bush and Clinton Administration Disaster Recovery Backup Tapes; final agency action. SUMMARY... collection of disaster recovery backup tapes from the George H.W. Bush and Clinton administrations under the...

The H+n-C5H12/n-C6H14→H2(v',j')+C5H11/C6H13 reactions: State-to-state dynamics and models of energy disposal

NASA Astrophysics Data System (ADS)

Picconatto, Carl A.; Srivastava, Abneesh; Valentini, James J.

2001-03-01

The rovibrational state distributions for the H2 product of the H+n-C5H12/n-C6H14→H2+C5H11/C6H13 reactions at 1.6 eV collision energy are reported. The results are compared to measurements made on the kinematically and energetically similar H+RH→H2+R (RH=CH4, C2H6, and C3H8) reactions as well as the atom-diatom reactions H+HX→H2+X(HX=HCl, HBr). For the title reactions, as for all the comparison reactions, the product appears in few of the energetically accessible states. This is interpreted as the result of a kinematic constraint on the product translational energy. Characteristic of the H+RH reactions we have previously studied, the title reactions show increasing rotational excitation of the H2 product with increasing vibrational excitation of it, a correlation that gets stronger as the size of the alkane increases. Trends and variations in the product energy disposal are analyzed and explained by a localized reaction model. This model predicates a truncation of the opacity function due to competing reactive sites in the polyatomic alkane reactant, and a relaxation of the otherwise tight coupling of energy and angular momentum conservation, because the polyatomic alkyl radical product is a sink for angular momentum.

Continuous haematic pH monitoring in extracorporeal circulation using a disposable florescence sensing element

NASA Astrophysics Data System (ADS)

Ferrari, Luca; Rovati, Luigi; Fabbri, Paola; Pilati, Francesco

2013-02-01

During extracorporeal circulation (ECC), blood is periodically sampled and analyzed to maintain the blood-gas status of the patient within acceptable limits. This protocol has well-known drawbacks that may be overcome by continuous monitoring. We present the characterization of a new pH sensor for continuous monitoring in ECC. This monitoring device includes a disposable fluorescence-sensing element directly in contact with the blood, whose fluorescence intensity is strictly related to the pH of the blood. In vitro experiments show no significant difference between the blood gas analyzer values and the sensor readings; after proper calibration, it gives a correlation of R>0.9887, and measuring errors were lower than the 3% of the pH range of interest (RoI) with respect to a commercial blood gas analyzer. This performance has been confirmed also by simulating a moderate ipothermia condition, i.e., blood temperature 32°C, frequently used in cardiac surgery. In ex vivo experiments, performed with animal models, the sensor is continuously operated in an extracorporeal undiluted blood stream for a maximum of 11 h. It gives a correlation of R>0.9431, and a measuring error lower than the 3% of the pH RoI with respect to laboratory techniques.

Continuous haematic pH monitoring in extracorporeal circulation using a disposable florescence sensing element.

PubMed

Ferrari, Luca; Rovati, Luigi; Fabbri, Paola; Pilati, Francesco

2013-02-01

During extracorporeal circulation (ECC), blood is periodically sampled and analyzed to maintain the blood-gas status of the patient within acceptable limits. This protocol has well-known drawbacks that may be overcome by continuous monitoring. We present the characterization of a new pH sensor for continuous monitoring in ECC. This monitoring device includes a disposable fluorescence-sensing element directly in contact with the blood, whose fluorescence intensity is strictly related to the pH of the blood. In vitro experiments show no significant difference between the blood gas analyzer values and the sensor readings; after proper calibration, it gives a correlation of R>0.9887, and measuring errors were lower than the 3% of the pH range of interest (RoI) with respect to a commercial blood gas analyzer. This performance has been confirmed also by simulating a moderate ipothermia condition, i.e., blood temperature 32°C, frequently used in cardiac surgery. In ex vivo experiments, performed with animal models, the sensor is continuously operated in an extracorporeal undiluted blood stream for a maximum of 11 h. It gives a correlation of R>0.9431, and a measuring error lower than the 3% of the pH RoI with respect to laboratory techniques.

16 CFR 682.3 - Proper disposal of consumer information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF CONSUMER REPORT INFORMATION AND RECORDS § 682.3 Proper disposal of consumer information. (a) Standard. Any person who maintains or otherwise possesses consumer information for a business purpose must... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Proper disposal of consumer information. 682...

16 CFR 682.3 - Proper disposal of consumer information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Proper disposal of consumer information. 682... OF CONSUMER REPORT INFORMATION AND RECORDS § 682.3 Proper disposal of consumer information. (a) Standard. Any person who maintains or otherwise possesses consumer information for a business purpose must...

Laser-induced fluorescence studies of excited Sr reactions: II. Sr(3P1)+CH3F, C2H5F, C2H4F2

NASA Astrophysics Data System (ADS)

Teule, J. M.; Janssen, M. H. M.; Bulthuis, J.; Stolte, S.

1999-06-01

The vibrational and rotational energy distributions of ground state SrF(X 2Σ) formed in the reactions of electronically excited Sr(3P1) with methylfluoride, ethylfluoride, and 1,1-difluoroethane have been studied by laser-induced fluorescence. Although the reactions of ground state Sr with these reactants are exothermic, no SrF products are observed for those reactions in this study. The fraction of available energy disposed into the sum of rotational and vibrational energy of the SrF(X 2Σ) product is approximately the same for all three reactions, i.e., 40%. The reaction of Sr(3P1) with CH3F results in very low vibrational excitation in the SrF reaction product. The product vibration increases in going to C2H5F and C2H4F2. It is concluded that the alkyl group influences the energy disposal mechanism in these reactions, and some suggestions are given for a partial explanation of the observations.

43 CFR 2743.3 - Leased disposal sites.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Leased disposal sites. 2743.3 Section 2743.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND PUBLIC PURPOSES ACT Recreation and...

43 CFR 2743.3 - Leased disposal sites.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Leased disposal sites. 2743.3 Section 2743.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND PUBLIC PURPOSES ACT Recreation and...

43 CFR 2743.3 - Leased disposal sites.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Leased disposal sites. 2743.3 Section 2743.3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND PUBLIC PURPOSES ACT Recreation and...

RNA SEQ Analysis Indicates that the AE3 Cl-/HCO3- Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart.

PubMed

Vairamani, Kanimozhi; Wang, Hong-Sheng; Medvedovic, Mario; Lorenz, John N; Shull, Gary E

2017-08-04

Loss of the AE3 Cl - /HCO 3 - exchanger (Slc4a3) in mice causes an impaired cardiac force-frequency response and heart failure under some conditions but the mechanisms are not known. To better understand the functions of AE3, we performed RNA Seq analysis of AE3-null and wild-type mouse hearts and evaluated the data with respect to three hypotheses (CO 2 disposal, facilitation of Na + -loading, and recovery from an alkaline load) that have been proposed for its physiological functions. Gene Ontology and PubMatrix analyses of differentially expressed genes revealed a hypoxia response and changes in vasodilation and angiogenesis genes that strongly support the CO 2 disposal hypothesis. Differential expression of energy metabolism genes, which indicated increased glucose utilization and decreased fatty acid utilization, were consistent with adaptive responses to perturbations of O 2 /CO 2 balance in AE3-null myocytes. Given that the myocardium is an obligate aerobic tissue and consumes large amounts of O 2 , the data suggest that loss of AE3, which has the potential to extrude CO 2 in the form of HCO 3 - , impairs O 2 /CO 2 balance in cardiac myocytes. These results support a model in which the AE3 Cl - /HCO 3 - exchanger, coupled with parallel Cl - and H + -extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-mediated disposal of CO 2 .

Field Test to Evaluate Deep Borehole Disposal.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, Ernest; Brady, Patrick Vane.; Clark, Andrew Jordan

The U.S. Department of Energy (DOE) has embarked on the Deep Borehole Field Test (DBFT), which will investigate whether conditions suitable for disposal of radioactive waste can be found at a depth of up to 5 km in the earth’s crust. As planned, the DBFT will demonstrate drilling and construction of two boreholes, one for initial scientific characterization, and the other at a larger diameter such as could be appropriate for waste disposal (the DBFT will not involve radioactive waste). A wide range of geoscience activities is planned for the Characterization Borehole, and an engineering demonstration of test package emplacementmore » and retrieval is planned for the larger Field Test Borehole. Characterization activities will focus on measurements and samples that are important for evaluating the long-term isolation capability of the Deep Borehole Disposal (DBD) concept. Engineering demonstration activities will focus on providing data to evaluate the concept’s operational safety and practicality. Procurement of a scientifically acceptable DBFT site and a site management contractor is now underway. The concept of deep borehole disposal (DBD) for radioactive wastes is not new. It was considered by the National Academy of Science (NAS 1957) for liquid waste, studied in the 1980’s in the U.S. (Woodward–Clyde 1983), and has been evaluated by European waste disposal R&D programs in the past few decades (for example, Grundfelt and Crawford 2014; Grundfelt 2010). Deep injection of wastewater including hazardous wastes is ongoing in the U.S. and regulated by the Environmental Protection Agency (EPA 2001). The DBFT is being conducted with a view to use the DBD concept for future disposal of smaller-quantity, DOE-managed wastes from nuclear weapons production (i.e., Cs/Sr capsules and granular solid wastes). However, the concept may also have broader applicability for nations that have a need to dispose of limited amounts of spent fuel from nuclear power reactors

Deep rock nuclear waste disposal test: design and operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klett, Robert D.

1974-09-01

An electrically heated test of nuclear waste simulants in granitic rock was conducted to demonstrate the feasibility of the concept of deep rock nuclear waste disposal and to obtain design data. This report describes the deep rock disposal sytstems study and the design and operation of the first concept feasibility test.

40 CFR 257.3 - Criteria for classification of solid waste disposal facilities and practices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR CLASSIFICATION OF SOLID WASTE DISPOSAL FACILITIES AND PRACTICES Classification of Solid Waste Disposal Facilities and Practices § 257.3 Criteria for classification of solid waste disposal facilities and practices. Solid waste disposal facilities or practices...

40 CFR 257.3 - Criteria for classification of solid waste disposal facilities and practices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR CLASSIFICATION OF SOLID WASTE DISPOSAL FACILITIES AND PRACTICES Classification of Solid Waste Disposal Facilities and Practices § 257.3 Criteria for classification of solid waste disposal facilities and practices. Solid waste disposal facilities or practices...

Comparison between a disposable and an electronic PCA device for labor epidural analgesia.

PubMed

Sumikura, Hiroyuki; van de Velde, Marc; Tateda, Takeshi

2004-01-01

The aims of the present study were (1) to investigate if a disposable patient-controlled analgesia (PCA) device can be used for labor analgesia and (2) to evaluate the device by midwives and parturients. Forty healthy parturients were divided into two groups and received combined spinal epidural analgesia for labor pain relief. Following intrathecal administration of 3 mg ropivacaine and 1.5 microg sufentanil, either a disposable PCA device (Coopdech Syrinjector; Daiken Medical, Osaka, Japan) or an electronic PCA device (IVAC PCAM PCA Syringe Pump; Alaris, Basingstoke, UK) was connected to the epidural catheter, and 0.15% ropivacaine with sufentanil 0.75 microg/ml was used for continuous infusion and PCA. For an electronic PCA device, continuous infusion rate, bolus dose, lockout time, and hourly limit were set at 4 ml/h, 3 ml, 15 min, and 16 ml, respectively. For a disposable PCA device, continuous infusion rate, bolus dose, and an hourly limit were set at 4 ml/h, 3 ml, and 16 ml, respectively, but lockout function was not available. No differences were observed between the groups concerning demographic data, obstetric data, and outcome of labor. Anesthetic requirements (disposable, 9.7 +/- 4.7 ml/h; electronic, 8.2 +/- 4.0 ml/h) and VAS score during the delivery (disposable, 26 +/- 25; electronic, 21 +/- 22) were similar between the groups. Midwives praised the disposable PCA device as well as the electronic one. The present results imply that the disposable PCA device can be an alternative to the electronic PCA device for labor analgesia.

hCG Triggering in ART: An Evolutionary Concept.

PubMed

Hershko Klement, Anat; Shulman, Adrian

2017-05-17

Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

10 CFR 61.7 - Concepts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.7 Concepts. (a) The disposal facility. (1) Part 61 is intended to apply to land disposal of... specific technical requirements for near-surface disposal of radioactive waste, a subset of land disposal...

10 CFR 61.7 - Concepts.

Code of Federal Regulations, 2012 CFR

2012-01-01

... COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.7 Concepts. (a) The disposal facility. (1) Part 61 is intended to apply to land disposal of... specific technical requirements for near-surface disposal of radioactive waste, a subset of land disposal...

10 CFR 61.7 - Concepts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.7 Concepts. (a) The disposal facility. (1) Part 61 is intended to apply to land disposal of... specific technical requirements for near-surface disposal of radioactive waste, a subset of land disposal...

10 CFR 61.7 - Concepts.

Code of Federal Regulations, 2013 CFR

2013-01-01

... COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.7 Concepts. (a) The disposal facility. (1) Part 61 is intended to apply to land disposal of... specific technical requirements for near-surface disposal of radioactive waste, a subset of land disposal...

10 CFR 61.7 - Concepts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.7 Concepts. (a) The disposal facility. (1) Part 61 is intended to apply to land disposal of... specific technical requirements for near-surface disposal of radioactive waste, a subset of land disposal...

Association rate constants for reactions between resonance-stabilized radicals: C 3H 3 + C 3H 3, C 3H 3 + C 3H 5, and C 3H 5 + C 3H 5

DOE PAGES

Georgievskii, Yuri; Miller, James A.; Klippenstein, Stephen J.

2007-05-18

Reactions between resonance-stabilized radicals play an important role in combustion chemistry. The theoretical prediction of rate coefficients and product distributions for such reactions is complicated by the fact that the initial complex-formation steps and some dissociation steps are barrierless. In this work, direct variable reaction coordinate transition state theory (VRC-TST) is used to predict accurately the association rate constants for the self and cross reactions of propargyl and allyl radicals. For each reaction, a set of multifaceted dividing surfaces is used to account for the multiple possible addition channels. Because of their resonant nature the geometric relaxation of the radicalsmore » is important. Here, the effect of this relaxation is explicitly calculated with the UB3LYP/cc-pvdz method for each mutual orientation encountered in the configurational integrals over the transition state dividing surfaces. The final energies are obtained from CASPT2/cc-pvdz calculations with all π-orbitals in the active space. Evaluations along the minimum energy path suggest that basis set corrections are negligible. The VRC-TST approach was also used to calculate the association rate constant and the corresponding number of states for the C 6H 5 + H → C 6H 6 exit channel of the C 3H 3 + C 3H 3 reaction, which is also barrierless. For this reaction, the interaction energies were evaluated with the CASPT2(2e,2o)/cc-pvdz method and a 1-D correction is included on the basis of CAS+1+2+QC/aug-cc-pvtz calculations for the CH 3 + H reference system. For the C 3H 3 + C 3H 3 reaction, the VRC-TST results for the energy and angular momentum resolved numbers of states in the entrance channels and in the C 6H 5 + H exit channel are incorporated in a master equation simulation to determine the temperature and pressure dependence of the phenomenological rate coefficients. The rate constants for the C 3H 3 + C 3H 3 and C 3H 5 + C 3H 5 self-reactions compare favorably

36 CFR 221.3 - Disposal of national forest timber according to management plans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Disposal of national forest timber according to management plans. 221.3 Section 221.3 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE TIMBER MANAGEMENT PLANNING § 221.3 Disposal of national forest timber...

Generic repository design concepts and thermal analysis (FY11).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Howard, Robert; Dupont, Mark; Blink, James A.

2011-08-01

Reference concepts for geologic disposal of used nuclear fuel and high-level radioactive waste in the U.S. are developed, including geologic settings and engineered barriers. Repository thermal analysis is demonstrated for a range of waste types from projected future, advanced nuclear fuel cycles. The results show significant differences among geologic media considered (clay/shale, crystalline rock, salt), and also that waste package size and waste loading must be limited to meet targeted maximum temperature values. In this study, the UFD R&D Campaign has developed a set of reference geologic disposal concepts for a range of waste types that could potentially be generatedmore » in advanced nuclear FCs. A disposal concept consists of three components: waste inventory, geologic setting, and concept of operations. Mature repository concepts have been developed in other countries for disposal of spent LWR fuel and HLW from reprocessing UNF, and these serve as starting points for developing this set. Additional design details and EBS concepts will be considered as the reference disposal concepts evolve. The waste inventory considered in this study includes: (1) direct disposal of SNF from the LWR fleet, including Gen III+ advanced LWRs being developed through the Nuclear Power 2010 Program, operating in a once-through cycle; (2) waste generated from reprocessing of LWR UOX UNF to recover U and Pu, and subsequent direct disposal of used Pu-MOX fuel (also used in LWRs) in a modified-open cycle; and (3) waste generated by continuous recycling of metal fuel from fast reactors operating in a TRU burner configuration, with additional TRU material input supplied from reprocessing of LWR UOX fuel. The geologic setting provides the natural barriers, and establishes the boundary conditions for performance of engineered barriers. The composition and physical properties of the host medium dictate design and construction approaches, and determine hydrologic and thermal responses

Chemical Stockpile Disposal Program. Risk Analysis of the Disposal of Chemical Munitions at Regional or National Sites.

DTIC Science & Technology

1987-08-01

THE DISPOSAL OF CNEM.. CU) GA TECHNOLOGIES INC SRN DIEGO CA A H SARSELL ET AL. RUG 97 GA-C- i @563 UNLRSS FIED S APEO-CDE-IS- 9 ?SIGDRAA±5-85-D-822...F/ 15/.3 NL I ihhhhhhhhhhhhlm I fflfflffllfllfllfllf smhhhhhhhhhhh ~1.02 U.,5 A I *Pig- FiLE copy CHEMICAL STOCKPILE DISPOSAL PROGRAM RISK ANALYSIS...vr~. ’ . - a ’ a’ ’- . ,I1 - .V [ N- VW; W UU V. , U .U : , r ,,, - . ..... . SECURITY CLASSIFICATION OF THIS PAGE IM : I omApproved

15 CFR 721.3 - Destruction or disposal of records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Destruction or disposal of records. 721.3 Section 721.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS...

15 CFR 721.3 - Destruction or disposal of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Destruction or disposal of records. 721.3 Section 721.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS...

Site Selection for the Disposal of LLW in Taiwan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chuang, W.S.; Chi, L.M.; Tien, N.C.

2006-07-01

This paper presents the implementation status of the low-level radioactive waste (LLW) disposal program in Taiwan, including the disposal facility regulations, status of waste management, final disposal program, licensing procedures, waste acceptance criteria, site selection criteria and processes and preliminary disposal concepts. The first phase of site selection for low-level radioactive waste final disposal in Taiwan was implemented between 1992 and 2002. The site selection process adopted a Geographic Information System (GIS), Hierarchical Analysis System, Expert Evaluation System, and site reconnaissance. An incentive program for voluntary sites was also initiated. After a series of evaluations and discussion of 30 potentialmore » candidate sites, including 8 recommended sites, 5 qualified voluntary townships, and several remote uninhabited small islets, Hsiao-chiou islet was selected as the first priority candidate site in February 1998. The geological investigation work in Hsiao-chiou was conducted from March 1999 through October 2000. An Environmental Impact Statement Report (EIS) and the Investment Feasibility Study Report (IFS) were submitted to the Environmental Protection Agency (EPA) in November 2000 and to the Ministry of Economic Affairs (MOEA) in June 2001, respectively. Unfortunately, the site investigation was discontinued in 2002 due to political and public acceptance consideration. After years of planning, the second phase of the site selection process was launched in August 2004 and will be conducted through 2008. It is planned that a repository will be constructed in early 2009 and start to operate in 2014. The site selection process for the second phase is based on the earlier work and four potential candidate sites were selected for evaluation until 2005. A near surface disposal concept is proposed for a site located in the Taiwan strait, and cavern disposal concepts are proposed for three other sites located on the main island. This

Electrochemical Disposal of Hydrazines in Water

NASA Technical Reports Server (NTRS)

Kim, Jinseong; Gonzalez-Mar, Anuncia; Salinas, Carlos; Rutherford, Larris; Jeng, King-Tsai; Andrews, Craig; Yalamanchili, Ratlaya

2007-01-01

An electrochemical method of disposal of hydrazines dissolved in water has been devised. The method is applicable to hydrazine (N2H4), to monomethyl hydrazine [also denoted by MMH or by its chemical formula, (CH3)HNNH2], and to unsymmetrical dimethyl hydrazine [also denoted UDMH or by its chemical formula, (CH3)2NNH2]. The method involves a room-temperature process that converts the hydrazine to the harmless products N2, H2O, and, in some cases, CO2

MANAGING UNCERTAINTIES ASSOCIATED WITH RADIOACTIVE WASTE DISPOSAL: TASK GROUP 4 OF THE IAEA PRISM PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seitz, R.

2011-03-02

It is widely recognized that the results of safety assessment calculations provide an important contribution to the safety arguments for a disposal facility, but cannot in themselves adequately demonstrate the safety of the disposal system. The safety assessment and a broader range of arguments and activities need to be considered holistically to justify radioactive waste disposal at any particular site. Many programs are therefore moving towards the production of what has become known as a Safety Case, which includes all of the different activities that are conducted to demonstrate the safety of a disposal concept. Recognizing the growing interest inmore » the concept of a Safety Case, the International Atomic Energy Agency (IAEA) is undertaking an intercomparison and harmonization project called PRISM (Practical Illustration and use of the Safety Case Concept in the Management of Near-surface Disposal). The PRISM project is organized into four Task Groups that address key aspects of the Safety Case concept: Task Group 1 - Understanding the Safety Case; Task Group 2 - Disposal facility design; Task Group 3 - Managing waste acceptance; and Task Group 4 - Managing uncertainty. This paper addresses the work of Task Group 4, which is investigating approaches for managing the uncertainties associated with near-surface disposal of radioactive waste and their consideration in the context of the Safety Case. Emphasis is placed on identifying a wide variety of approaches that can and have been used to manage different types of uncertainties, especially non-quantitative approaches that have not received as much attention in previous IAEA projects. This paper includes discussions of the current results of work on the task on managing uncertainty, including: the different circumstances being considered, the sources/types of uncertainties being addressed and some initial proposals for approaches that can be used to manage different types of uncertainties.« less

Communication: Reactivity borrowing in the mode selective chemistry of H + CHD3 → H2 + CD3

NASA Astrophysics Data System (ADS)

Ellerbrock, Roman; Manthe, Uwe

2017-12-01

Quantum state-resolved reaction probabilities for the H + CHD3 → H2 + CD3 reaction are calculated by accurate full-dimensional quantum dynamics calculations using the multi-layer multi-configurational time-dependent Hartree approach and the quantum transition state concept. Reaction probabilities of various ro-vibrational states of the CHD3 reactant are investigated for vanishing total angular momentum. While the reactivity of the different vibrational states of CHD3 mostly follows intuitive patterns, an unusually large reaction probability is found for CHD3 molecules triply excited in the CD3 umbrella-bending vibration. This surprising reactivity can be explained by a Fermi resonance-type mixing of the single CH-stretch excited and the triple CD3 umbrella-bend excited vibrational states of CHD3. These findings show that resonant energy transfer can significantly affect the mode-selective chemistry of CHD3 and result in counter-intuitive reactivity patterns.

Safety aspects of nuclear waste disposal in space

NASA Technical Reports Server (NTRS)

Rice, E. E.; Edgecombe, D. S.; Compton, P. R.

1981-01-01

Safety issues involved in the disposal of nuclear wastes in space as a complement to mined geologic repositories are examined as part of an assessment of the feasibility of nuclear waste disposal in space. General safety guidelines for space disposal developed in the areas of radiation exposure and shielding, containment, accident environments, criticality, post-accident recovery, monitoring systems and isolation are presented for a nuclear waste disposal in space mission employing conventional space technology such as the Space Shuttle. The current reference concept under consideration by NASA and DOE is then examined in detail, with attention given to the waste source and mix, the waste form, waste processing and payload fabrication, shipping casks and ground transport vehicles, launch site operations and facilities, Shuttle-derived launch vehicle, orbit transfer vehicle, orbital operations and space destination, and the system safety aspects of the concept are discussed for each component. It is pointed out that future work remains in the development of an improved basis for the safety guidelines and the determination of the possible benefits and costs of the space disposal option for nuclear wastes.

48 CFR 49.206-3 - Submission of inventory disposal schedules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of inventory disposal schedules. 49.206-3 Section 49.206-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts...

SPECIAL ANALYSIS FOR SLIT TRENCH DISPOSAL OF THE REACTOR PROCESS HEAT EXCHANGERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamm, L.; Collard, L.; Aleman, S.

2012-06-18

The Savannah River National Laboratory (SRNL), in response to a request from Solid Waste Management (SWM), conducted a Special Analysis (SA) to evaluate the performance of nineteen heat exchangers that are to be disposed in the E-Area low level waste facility Slit Trench 9 (ST 9). Although these nineteen heat exchangers were never decontaminated, the majority of the radionuclides in the heat exchanger inventory list were determined to be acceptable for burial because they are less than the 'generic' waste form inventory limits given in the 2008 Performance Assessment (PA) (WSRC, 2008). However, as generic waste, the H-3 and C-14more » inventories resulted in unacceptable sum-of-fractions (SOFs). Initial scoping analyses performed by SRNL indicated that if alterations were made to certain external nozzles to mitigate various potential leak paths, acceptable SOFs could be achieved through the use of a 'Special' waste form. This SA provides the technical basis for this new 'Special' waste form and provides the inventory limits for H-3 and C-14 for these nineteen heat exchangers such that the nineteen heat exchangers can be disposed in ST 9. This 'Special' waste form is limited to these nineteen heat exchangers in ST 9 and applies for H-3 and C-14, which are designated as H-3X and C-14X, respectively. The SA follows the same methodology used in the 2008 PA and the 2008 SA except for the modeling enhancements noted below. Infiltration rates above the heat exchangers are identical to those used in the 2008 PA; however, flow through the heat exchangers is unique. Because it is unknown exactly how sealed heat exchanger openings will perform and how surface and embedded contaminants will be released, multiple base cases or scenarios were established to investigate a set of performances. Each scenario consists of flow options (based on the performance of sealed openings) and a near-field release of contaminants (based on corrosion and diffusion performance). Two disposal

Knowledge based systems: A preliminary survey of selected issues and techniques

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Kavi, Srinu

1984-01-01

It is only recently that research in Artificial Intelligence (AI) is accomplishing practical results. Most of these results can be attributed to the design and use of expert systems (or Knowledge-Based Systems, KBS) - problem-solving computer programs that can reach a level of performance comparable to that of a human expert in some specialized problem domain. But many computer systems designed to see images, hear sounds, and recognize speech are still in a fairly early stage of development. In this report, a preliminary survey of recent work in the KBS is reported, explaining KBS concepts and issues and techniques used to construct them. Application considerations to construct the KBS and potential KBS research areas are identified. A case study (MYCIN) of a KBS is also provided.

Computational study of red- and blue-shifted Csbnd H⋯Se hydrogen bond in Q3Csbnd H⋯SeH2 (Q = Cl, F, H) complexes

NASA Astrophysics Data System (ADS)

Chopra, Pragya; Chakraborty, Shamik

2018-01-01

This work presents Csbnd H⋯Se hydrogen bonding interaction at the MP2 level of theory. The system Q3Csbnd H⋯SeH2 (Q = Cl, F, and H) provides an opportunity to investigate red- and blue-shifted hydrogen bonds. The origin of the red- and blue-shift in Csbnd H stretching frequency has been investigated using Natural Bond Orbital analysis. A large amount of electron density is being transferred to the σ∗Csbnd H orbital in red-shifted Cl3Csbnd H⋯SeH2. Electron density transfer in the blue-shifted F3Csbnd H⋯SeH2 is primarily to the remote fluorine atoms. Further, due to polarization of the Csbnd H bond, the contradicting effects of rehybridization and hyperconjugation are important. The extent of hyperconjugation reigns predominant in explaining the nature of the Csbnd H⋯Se hydrogen bond in Q3Csbnd H⋯SeH2 complexes as the hydrogen bond acceptor remain same in this investigation. Red- and blue-shift in Q3Csbnd H⋯SeH2 (Q = Cl and F) complexes is best described by pro-improper hydrogen bond donor concept.

High-Level Radioactive Waste: Safe Storage and Ultimate Disposal.

ERIC Educational Resources Information Center

Dukert, Joseph M.

Described are problems and techniques for safe disposal of radioactive waste. Degrees of radioactivity, temporary storage, and long-term permanent storage are discussed. Included are diagrams of estimated waste volumes to the year 2000 and of an artist's conception of a permanent underground disposal facility. (SL)

DESM: portal for microbial knowledge exploration systems.

PubMed

Salhi, Adil; Essack, Magbubah; Radovanovic, Aleksandar; Marchand, Benoit; Bougouffa, Salim; Antunes, Andre; Simoes, Marta Filipa; Lafi, Feras F; Motwalli, Olaa A; Bokhari, Ameerah; Malas, Tariq; Amoudi, Soha Al; Othum, Ghofran; Allam, Intikhab; Mineta, Katsuhiko; Gao, Xin; Hoehndorf, Robert; C Archer, John A; Gojobori, Takashi; Bajic, Vladimir B

2016-01-04

Microorganisms produce an enormous variety of chemical compounds. It is of general interest for microbiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microorganisms and their ability for bioproduction. To enable such exploration, we compiled 45 topic-specific knowledgebases (KBs) accessible through DESM portal (www.cbrc.kaust.edu.sa/desm). The KBs contain information derived through text-mining of PubMed information and complemented by information data-mined from various other resources (e.g. ChEBI, Entrez Gene, GO, KOBAS, KEGG, UniPathways, BioGrid). All PubMed records were indexed using 4,538,278 concepts from 29 dictionaries, with 1 638 986 records utilized in KBs. Concepts used are normalized whenever possible. Most of the KBs focus on a particular type of microbial activity, such as production of biocatalysts or nutraceuticals. Others are focused on specific categories of microorganisms, e.g. streptomyces or cyanobacteria. KBs are all structured in a uniform manner and have a standardized user interface. Information exploration is enabled through various searches. Users can explore statistically most significant concepts or pairs of concepts, generate hypotheses, create interactive networks of associated concepts and export results. We believe DESM will be a useful complement to the existing resources to benefit microbiology and biotechnology research. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

[Trial manufacture of a plunger shield for a disposable plastic syringe].

PubMed

Murakami, Shigeki; Emoto, Takashi; Mori, Hiroshige; Fujita, Katsuhisa; Kubo, Naoki

2008-08-20

A syringe-type radiopharmaceutical being supplied by a manufacturer has a syringe shield and a plunger shield, whereas an in-hospital labeling radiopharmaceutical is administered by a disposable plastic syringe without the plunger shield. In cooperation with Nihon Medi-Physics Co. Ltd., we have produced a new experimental plunger shield for the disposable plastic syringe. In order to evaluate this shielding effect, we compared the leaked radiation doses of our plunger shield with those of the syringe-type radiopharmaceutical (Medi shield type). Our plunger shield has a lead plate of 21 mm in diameter and 3 mm thick. This shield is equipped with the plunger-end of a disposal plastic syringe. We sealed 99mTc solution into a plastic syringe (Terumo Co.) of 5 ml with our plunger shield and Medi shield type of 2 ml. We measured leaked radiation doses around syringes using fluorescent glass dosimeters (Dose Ace). The number of measure points was 18. The measured doses were converted to 70 microm dose equivalent at 740 MBq of radioactivity. The results of our plunger shield and the Medi shield type were as follows: 4-13 microSv/h and 3-14 microSv/h at shielding areas, 3-545 microSv/h and 6-97 microSv/h at non-shielding areas, 42-116 microSv/h and 88-165 microSv/h in the vicinity of the syringe shield, and 1071 microSv/h and 1243 microSv/h at the front of the needle. For dose rates of shielding areas around the syringe, the shielding effects were approximately the same as those of the Medi shield type. In conclusion, our plunger shield may be useful for reducing finger exposure during the injection of an in-hospital labeled radiopharmaceutical.

WO3 nanoparticle-based conformable pH sensor.

PubMed

Santos, Lídia; Neto, Joana P; Crespo, Ana; Nunes, Daniela; Costa, Nuno; Fonseca, Isabel M; Barquinha, Pedro; Pereira, Luís; Silva, Jorge; Martins, Rodrigo; Fortunato, Elvira

2014-08-13

pH is a vital physiological parameter that can be used for disease diagnosis and treatment as well as in monitoring other biological processes. Metal/metal oxide based pH sensors have several advantages regarding their reliability, miniaturization, and cost-effectiveness, which are critical characteristics for in vivo applications. In this work, WO3 nanoparticles were electrodeposited on flexible substrates over metal electrodes with a sensing area of 1 mm(2). These sensors show a sensitivity of -56.7 ± 1.3 mV/pH, in a wide pH range of 9 to 5. A proof of concept is also demonstrated using a flexible reference electrode in solid electrolyte with a curved surface. A good balance between the performance parameters (sensitivity), the production costs, and simplicity of the sensors was accomplished, as required for wearable biomedical devices.

EXPERIENCES FROM THE SOURCE-TERM ANALYSIS OF A LOW AND INTERMEDIATE LEVEL RADWASTE DISPOSAL FACILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park,Jin Beak; Park, Joo-Wan; Lee, Eun-Young

2003-02-27

Enhancement of a computer code SAGE for evaluation of the Korean concept for a LILW waste disposal facility is discussed. Several features of source term analysis are embedded into SAGE to analyze: (1) effects of degradation mode of an engineered barrier, (2) effects of dispersion phenomena in the unsaturated zone and (3) effects of time dependent sorption coefficient in the unsaturated zone. IAEA's Vault Safety Case (VSC) approach is used to demonstrate the ability of this assessment code. Results of MASCOT are used for comparison purposes. These enhancements of the safety assessment code, SAGE, can contribute to realistic evaluation ofmore » the Korean concept of the LILW disposal project in the near future.« less

Advances in Geologic Disposal System Modeling and Shale Reference Cases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mariner, Paul E.; Stein, Emily R.; Frederick, Jennifer M.

The Spent Fuel and Waste Science and Technology (SFWST) Campaign of the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Office of Fuel Cycle Technology (OFCT) is conducting research and development (R&D) on geologic disposal of spent nuclear fuel (SNF) and high level nuclear waste (HLW). Two high priorities for SFWST disposal R&D are design concept development and disposal system modeling (DOE 2011, Table 6). These priorities are directly addressed in the SFWST Generic Disposal Systems Analysis (GDSA) work package, which is charged with developing a disposal system modeling and analysis capability for evaluating disposal system performance formore » nuclear waste in geologic media (e.g., salt, granite, shale, and deep borehole disposal).« less

Perspectives of Future R and D on HLW Disposal in Germany

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steininger, W.J.

2008-07-01

The 5. Energy Research Program of the Federal Government 'Innovation and New Technology' is the general framework for R and D activities in radioactive waste disposal. The Ministry of Economics and Technology (BMWi), the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) and the Ministry of Education and Research (BMBF) apply the Research Program concerning their respective responsibilities and competences. With regard to the Government's obligation to provide repositories for HLW (spent fuel and vitrified HAW) radioactive waste basic and applied R and D is needed in order to make adequate knowledge available to implementers, decision makersmore » and stakeholders in general. Non-site specific R and D projects are funded by BMWi on the basis of its Research Concept. In the first stage (1998 -2001) most R and D issues were focused on R and D activities related to HLW disposal in rock salt. By that time the R and D program had to be revised and some prioritization was demanded due to changes in politics. In the current version (2001 -2006) emphasize was put on non-saline rocks. The current Research Concept of BMWi is presently subjected to a sort of revision, evaluation, and discussion, inter alia, by experts from several German research institutions. This activity is of special importance against the background of streamlining and focusing the research activities to future demands, priorities and perspectives with regard to the salt concept and the option of disposing of HLW in argillaceous media. Because the status of knowledge on disposal in rock salt is well advanced, it is necessary to take stock of the current state-of-the-art. In this framework some key projects are being currently carried out. The results may contribute to future decisions to be made in Germany with respect to HLW disposal. The first project deals with the development of an advanced safety concept for a HLW waste repository in rock salt. The second project

Design consideration in constructing high performance embedded Knowledge-Based Systems (KBS)

NASA Technical Reports Server (NTRS)

Dalton, Shelly D.; Daley, Philip C.

1988-01-01

As the hardware trends for artificial intelligence (AI) involve more and more complexity, the process of optimizing the computer system design for a particular problem will also increase in complexity. Space applications of knowledge based systems (KBS) will often require an ability to perform both numerically intensive vector computations and real time symbolic computations. Although parallel machines can theoretically achieve the speeds necessary for most of these problems, if the application itself is not highly parallel, the machine's power cannot be utilized. A scheme is presented which will provide the computer systems engineer with a tool for analyzing machines with various configurations of array, symbolic, scaler, and multiprocessors. High speed networks and interconnections make customized, distributed, intelligent systems feasible for the application of AI in space. The method presented can be used to optimize such AI system configurations and to make comparisons between existing computer systems. It is an open question whether or not, for a given mission requirement, a suitable computer system design can be constructed for any amount of money.

Alternative disposal options for transuranic waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loomis, G.G.

1994-12-31

Three alternative concepts are proposed for the final disposal of stored and retrieved buried transuranic waste. These proposed options answer criticisms of the existing U.S. Department of Energy strategy of directly disposing of stored transuranic waste in deep, geological salt formations at the Waste Isolation Pilot Plant (WIPP) in Carlsbad, New Mexico. The first option involves enhanced stabilization of stored waste by thermal treatment followed by convoy transportation and internment in the existing WIPP facility. This concept could also be extended to retrieved buried waste with proper permitting. The second option involves in-state, in situ internment using an encapsulating lensmore » around the waste. This concept applies only to previously buried transuranic waste. The third option involves sending stored and retrieved waste to the Nevada Test Site and configuring the waste around a thermonuclear device from the U.S. or Russian arsenal in a specially designed underground chamber. The thermonuclear explosion would transmute plutonium and disassociate hazardous materials while entombing the waste in a national sacrifice area.« less

43 CFR 2743.3-1 - Patent provisions for leased disposal sites.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Patent provisions for leased disposal sites. 2743.3-1 Section 2743.3-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND...

43 CFR 2743.3-1 - Patent provisions for leased disposal sites.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Patent provisions for leased disposal sites. 2743.3-1 Section 2743.3-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND...

43 CFR 2743.3-1 - Patent provisions for leased disposal sites.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Patent provisions for leased disposal sites. 2743.3-1 Section 2743.3-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) RECREATION AND...

Chemical Stockpile Disposal Program. Monitoring Concept Plan

DTIC Science & Technology

1987-09-10

Government Owned Contractor Operated GPL General Population Limit H Bis (2-chloroethyl) sulfide or Levinstein Mustard (75% purity) P HCI Hydrogen Chloride... government agencies, will provide technical expertise and equipment necessary to monitor affected areas and resources. 2-25 SECTIO 3 PROCESS CONTROL AND...conditions and to issue correct emergency response notifications, if required. The process sensors work in conjunction with the process control system and

22 CFR 3.9 - Disposal of gifts and decorations which become the property of the United States.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Disposal of gifts and decorations which become the property of the United States. 3.9 Section 3.9 Foreign Relations DEPARTMENT OF STATE GENERAL GIFTS AND DECORATIONS FROM FOREIGN GOVERNMENTS § 3.9 Disposal of gifts and decorations which become the...

A Co3O4-CDots-C3N4 three component electrocatalyst design concept for efficient and tunable CO2 reduction to syngas.

PubMed

Guo, Sijie; Zhao, Siqi; Wu, Xiuqin; Li, Hao; Zhou, Yunjie; Zhu, Cheng; Yang, Nianjun; Jiang, Xin; Gao, Jin; Bai, Liang; Liu, Yang; Lifshitz, Yeshayahu; Lee, Shuit-Tong; Kang, Zhenhui

2017-11-28

Syngas, a CO and H 2 mixture mostly generated from non-renewable fossil fuels, is an essential feedstock for production of liquid fuels. Electrochemical reduction of CO 2 and H + /H 2 O is an alternative renewable route to produce syngas. Here we introduce the concept of coupling a hydrogen evolution reaction (HER) catalyst with a CDots/C 3 N 4 composite (a CO 2 reduction catalyst) to achieve a cheap, stable, selective and efficient route for tunable syngas production. Co 3 O 4 , MoS 2 , Au and Pt serve as the HER component. The Co 3 O 4 -CDots-C 3 N 4 electrocatalyst is found to be the most efficient among the combinations studied. The H 2 /CO ratio of the produced syngas is tunable from 0.07:1 to 4:1 by controlling the potential. This catalyst is highly stable for syngas generation (over 100 h) with no other products besides CO and H 2 . Insight into the mechanisms balancing between CO 2 reduction and H 2 evolution when applying the HER-CDots-C 3 N 4 catalyst concept is provided.

Integrated approach to modeling long-term durability of concrete engineered barriers in LLRW disposal facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, J.H.; Roy, D.M.; Mann, B.

1995-12-31

This paper describes an integrated approach to developing a predictive computer model for long-term performance of concrete engineered barriers utilized in LLRW and ILRW disposal facilities. The model development concept consists of three major modeling schemes: hydration modeling of the binder phase, pore solution speciation, and transport modeling in the concrete barrier and service environment. Although still in its inception, the model development approach demonstrated that the chemical and physical properties of complex cementitious materials and their interactions with service environments can be described quantitatively. Applying the integrated model development approach to modeling alkali (Na and K) leaching from amore » concrete pad barrier in an above-grade tumulus disposal unit, it is predicted that, in a near-surface land disposal facility where water infiltration through the facility is normally minimal, the alkalis control the pore solution pH of the concrete barriers for much longer than most previous concrete barrier degradation studies assumed. The results also imply that a highly alkaline condition created by the alkali leaching will result in alteration of the soil mineralogy in the vicinity of the disposal facility.« less

Structural classification of CDR-H3 revisited: a lesson in antibody modeling.

PubMed

Kuroda, Daisuke; Shirai, Hiroki; Kobori, Masato; Nakamura, Haruki

2008-11-15

Among the six complementarity-determining regions (CDRs) in the variable domains of an antibody, the third CDR of the heavy chain (CDR-H3), which lies in the center of the antigen-binding site, plays a particularly important role in antigen recognition. CDR-H3 shows significant variability in its length, sequence, and structure. Although difficult, model building of this segment is the most critical step in antibody modeling. Since our first proposal of the "H3-rules," which classify CDR-H3 structure based on amino acid sequence, the number of experimentally determined antibody structures has increased. Here, we revise these H3-rules and propose an improved classification scheme for CDR-H3 structure modeling. In addition, we determine the common features of CDR-H3 in antibody drugs as well as discuss the concept of "antibody druggability," which can be applied as an indicator of antibody evaluation during drug discovery.

Logistics Modeling of Emplacement Rate and Duration of Operations for Generic Geologic Repository Concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, Elena Arkadievna; Hardin, Ernest

This study identified potential geologic repository concepts for disposal of spent nuclear fuel (SNF) and (2) evaluated the achievable repository waste emplacement rate and the time required to complete the disposal for these concepts. Total repository capacity is assumed to be approximately 140,000 MT of spent fuel. The results of this study provide an important input for the rough-order-of-magnitude (ROM) disposal cost analysis. The disposal concepts cover three major categories of host geologic media: crystalline or hard rock, salt, and argillaceous rock. Four waste package sizes are considered: 4PWR/9BWR; 12PWR/21BWR; 21PWR/44BWR, and dual purpose canisters (DPCs). The DPC concepts assumemore » that the existing canisters will be sealed into disposal overpacks for direct disposal. Each concept assumes one of the following emplacement power limits for either emplacement or repository closure: 1.7 kW; 2.2 kW; 5.5 kW; 10 kW; 11.5 kW, and 18 kW.« less

Analysis of space systems study for the space disposal of nuclear waste. Study report, volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1981-01-01

Space systems concepts were identified and defined and evaluated as to their performance, risks, and technical viability in order to select the most attractive approach for disposal of high level nuclear wastes in space. Major study areas discussed include: (1) mission and operations analysis; (2) waste payload systems; (3) flight support system; (4) launch site systems; (5) launch vehicle systems; (6) orbit transfer system; (7) space disposal destinations; and (8) systems integration and evaluation.

Regulating the disposal of cigarette butts as toxic hazardous waste.

PubMed

Barnes, Richard L

2011-05-01

The trillions of cigarette butts generated each year throughout the world pose a significant challenge for disposal regulations, primarily because there are millions of points of disposal, along with the necessity to segregate, collect and dispose of the butts in a safe manner, and cigarette butts are toxic, hazardous waste. There are some hazardous waste laws, such as those covering used tyres and automobile batteries, in which the retailer is responsible for the proper disposal of the waste, but most post-consumer waste disposal is the responsibility of the consumer. Concepts such as extended producer responsibility (EPR) are being used for some post-consumer waste to pass the responsibility and cost for recycling or disposal to the manufacturer of the product. In total, 32 states in the US have passed EPR laws covering auto switches, batteries, carpet, cell phones, electronics, fluorescent lighting, mercury thermostats, paint and pesticide containers, and these could be models for cigarette waste legislation. A broader concept of producer stewardship includes EPR, but adds the consumer and the retailer into the regulation. The State of Maine considered a comprehensive product stewardship law in 2010 that is a much better model than EPR. By using either EPR or the Maine model, the tobacco industry will be required to cover the cost of collecting and disposing of cigarette butt waste. Additional requirements included in the Maine model are needed for consumers and businesses to complete the network that will be necessary to maximise the segregation and collection of cigarette butts to protect the environment.

Regulating the disposal of cigarette butts as toxic hazardous waste

PubMed Central

2011-01-01

The trillions of cigarette butts generated each year throughout the world pose a significant challenge for disposal regulations, primarily because there are millions of points of disposal, along with the necessity to segregate, collect and dispose of the butts in a safe manner, and cigarette butts are toxic, hazardous waste. There are some hazardous waste laws, such as those covering used tyres and automobile batteries, in which the retailer is responsible for the proper disposal of the waste, but most post-consumer waste disposal is the responsibility of the consumer. Concepts such as extended producer responsibility (EPR) are being used for some post-consumer waste to pass the responsibility and cost for recycling or disposal to the manufacturer of the product. In total, 32 states in the US have passed EPR laws covering auto switches, batteries, carpet, cell phones, electronics, fluorescent lighting, mercury thermostats, paint and pesticide containers, and these could be models for cigarette waste legislation. A broader concept of producer stewardship includes EPR, but adds the consumer and the retailer into the regulation. The State of Maine considered a comprehensive product stewardship law in 2010 that is a much better model than EPR. By using either EPR or the Maine model, the tobacco industry will be required to cover the cost of collecting and disposing of cigarette butt waste. Additional requirements included in the Maine model are needed for consumers and businesses to complete the network that will be necessary to maximise the segregation and collection of cigarette butts to protect the environment. PMID:21504925

3DD - Three Dimensional Disposal of Spent Nuclear Fuel - 12449

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dvorakova, Marketa; Slovak, Jiri

2012-07-01

Three dimensional disposal is being considered as a way in which to store long-term spent nuclear fuel in underground disposal facilities in the Czech Republic. This method involves a combination of the two most common internationally recognised disposal methods in order to practically apply the advantages of both whilst, at the same time, eliminating their weaknesses; the method also allows easy removal in case of potential re-use. The proposed method for the disposal of spent nuclear fuel will reduce the areal requirements of future deep geological repositories by more than 30%. It will also simplify the container handling process bymore » using gravitational forces in order to meet requirements concerning the controllability of processes and ensuring operational and nuclear safety. With regard to the issue of the efficient potential removal of waste containers, this project offers an ingenious solution which does not disrupt the overall stability of the original disposal complex. (authors)« less

40 CFR 229.3 - Transportation and disposal of vessels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... bottom rapidly and that marine navigation is not otherwise impaired. (6) Disposal shall not take place in... procedures; (iv) Information on the potential effect of the vessel disposal on the marine environment; and (v... practicable all materials which may degrade the marine environment, including without limitation (i) emptying...

Disposable versus non-disposable tonometer prisms: a UK national survey

PubMed Central

Jasani, Kirti M; Putri, Christine; Pearl, Amy; Sattar, Nayeem; Mercieca, Karl; Spaeth, George; Bhan-Bhargava, Archana

2017-01-01

Purpose To determine the prevalence of disposable tonometer versus non-disposable tonometer use in the UK and to determine methods of decontamination and frequency of replacement of prisms. A total of 137 ophthalmology departments were interviewed by telephone using a structured questionnaire. The main outcome measured were:types of tonometer prisms used in clinic (disposable, non-disposable and/or other)average disposable prisms used per clinic sessionaverage lifespan of non-disposable prismsprism preference by glaucoma and other teams within department. A cost and benefit analysis was then performed on the data acquired. Results One hundred and fifty-five departments were identified for the survey. Of these, 137 (88.3%) responded. Eighty-one departments (59.1%) used Tonosafe prisms alone, whereas 22 departments (16.1%) used Goldmann non-disposable prisms exclusively. Thirty-five departments (64%) on average have a change rate of 26.5% per year (range: 0–100, median: 20) attributed to damage, loss or theft. Sixteen departments (29%) reported that prisms were used until damaged or lost. Four departments (7%) were uncertain of their prism usage and could not provide further information. Conclusions Majority of eye departments in the UK opt for disposable prisms. This survey shows the perceived cost-effectiveness of disposable prisms is overestimated when the true cost of disinfection and damage is taken into account. Significant cost savings coupled with the low risk of infectivity (if decontaminated properly) should prompt clinicians and ophthalmic departments worldwide to reconsider the use of non-disposable prisms. PMID:29354698

Synthesis of polycyclic molecules by double C(sp2)-H/C(sp3)-H arylations with a single palladium catalyst.

PubMed

Pierre, Cathleen; Baudoin, Olivier

2011-04-01

Polycyclic molecules were obtained in good yields by double C(sp(2))-H/C(sp(3))-H arylations mediated by a single palladium/phosphine catalyst. Both double intermolecular/intramolecular and intramolecular/intramolecular C-C couplings were performed successfully, which indicates that this concept has a broad applicability for the rapid construction of molecular complexity.

Study on Potential Changes in Geological and Disposal Environment Caused by 'Natural Phenomena' on a HLW Disposal System

NASA Astrophysics Data System (ADS)

Kawamura, M.; Umeda, K.; Ohi, T.; Ishimaru, T.; Niizato, T.; Yasue, K.; Makino, H.

2007-12-01

We have developed a formal evaluation method to assess the potential impact of natural phenomena (earthquakes and faulting; volcanism; uplift, subsidence, denudation and sedimentation; climatic and sea-level changes) on a High Level Radioactive Waste (HLW) Disposal System. In 2000, we had developed perturbation scenarios in a generic and conservative sense and illustrated the potential impact on a HLW disposal system. As results of the development of perturbation scenarios, two points were highlighted for consideration in subsequent work: improvement of the scenarios from the viewpoints of reality, transparency, traceability and consistency and avoiding extreme conservatism. Subsequently, we have thus developed a new procedure for describing such perturbation scenarios based on further studies of the characteristics of these natural perturbation phenomena in Japan. The approach to describing the perturbation scenario is effectively developed in five steps: Step 1: Description of potential process of phenomena and their impacts on the geological environment. Step 2: Characterization of potential changes of geological environment in terms of T-H-M-C (Thermal - Hydrological - Mechanical - Chemical) processes. The focus is on specific T-H-M-C parameters that influence geological barrier performance, utilizing the input from Step 1. Step 3: Classification of potential influences, based on similarity of T-H-M-C perturbations. This leads to development of perturbation scenarios to serve as a basis for consequence analysis. Step 4: Establishing models and parameters for performance assessment. Step 5: Calculation and assessment. This study focuses on identifying key T-H-M-C process associated with perturbations at Step 2. This framework has two advantages. First one is assuring maintenance of traceability during the scenario construction processes, facilitating the production and structuring of suitable records. The second is providing effective elicitation and

Short-term response of subadult white sturgeon to hopper dredge disposal operations

USGS Publications Warehouse

Parsley, Michael J.; Popoff, Nicholas D.; Romine, Jason G.

2011-01-01

The effect of dredged-material disposal operations on the behavior of seven white sturgeon Acipenser transmontanus (50–101 cm fork length) was examined by analysis of the movements and depth use of these fish before, during, and after a series of hopper dredge disposal operations in the lower Columbia River. Analyses of fish locations showed that 12 flow-lane disposal operations within a 24-h period had minimal effect on subadult white sturgeon behavior; six of the seven fish showed slight attraction to the disposal area during disposals, and one fish increased its distance from the disposal area. The core area for all fish combined shifted toward the disposal area during disposals. In the 24 h after completion of the disposal operations the fish core areas shifted back toward those areas occupied before the disposals. The rates of movement, depths used, and diel movement patterns of the white sturgeon showed little change over all periods, suggesting that natural behaviors were not altered during and immediately after hopper dredge disposal operations.

The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana.

PubMed

Wollmann, Heike; Stroud, Hume; Yelagandula, Ramesh; Tarutani, Yoshiaki; Jiang, Danhua; Jing, Li; Jamge, Bhagyshree; Takeuchi, Hidenori; Holec, Sarah; Nie, Xin; Kakutani, Tetsuji; Jacobsen, Steven E; Berger, Frédéric

2017-05-18

Gene bodies of vertebrates and flowering plants are occupied by the histone variant H3.3 and DNA methylation. The origin and significance of these profiles remain largely unknown. DNA methylation and H3.3 enrichment profiles over gene bodies are correlated and both have a similar dependence on gene transcription levels. This suggests a mechanistic link between H3.3 and gene body methylation. We engineered an H3.3 knockdown in Arabidopsis thaliana and observed transcription reduction that predominantly affects genes responsive to environmental cues. When H3.3 levels are reduced, gene bodies show a loss of DNA methylation correlated with transcription levels. To study the origin of changes in DNA methylation profiles when H3.3 levels are reduced, we examined genome-wide distributions of several histone H3 marks, H2A.Z, and linker histone H1. We report that in the absence of H3.3, H1 distribution increases in gene bodies in a transcription-dependent manner. We propose that H3.3 prevents recruitment of H1, inhibiting H1's promotion of chromatin folding that restricts access to DNA methyltransferases responsible for gene body methylation. Thus, gene body methylation is likely shaped by H3.3 dynamics in conjunction with transcriptional activity.

Average rainwater pH, concepts of atmospheric acidity, and buffering in open systems

NASA Astrophysics Data System (ADS)

Liljestrand, Howard M.

The system of water equilibrated with a constant partial pressure of CO 2, as a reference point for pH acidity-alkalinity relationships, has nonvolatile acidity and alkalinity components as conservative quantities, but not [H +]. Simple algorithms are presented for the determination of the average pH for combinations of samples both above and below pH 5.6. Averaging the nonconservative quantity [H +] yields erroneously low mean pH values. To extend the open CO 2 system to include other volatile atmospheric acids and bases distributed among the gas, liquid and particulate matter phases, a theoretical framework for atmospheric acidity is presented. Within certain oxidation-reduction limitations, the total atmospheric acidity (but not free acidity) is a conservative quantity. The concept of atmospheric acidity is applied to air-water systems approximating aerosols, fogwater, cloudwater and rainwater. The buffer intensity in hydrometeors is described as a function of net strong acidity, partial pressures of acid and base gases and the water to air ratio. For high liquid to air volume ratios, the equilibrium partial pressures of trace acid and base gases are set by the pH or net acidity controlled by the nonvolatile acid and base concentrations. For low water to air volume ratios as well as stationary state systems such as precipitation scavenging with continuous emissions, the partial pressures of trace gases (NH 3, HCl, HNO 3, SO 2 and CH 3COOH) appear to be of greater or equal importance as carbonate species as buffers in the aqueous phase.

The interstellar chemistry of C3H and C3H2 isomers

PubMed Central

Loison, Jean-Christophe; Agúndez, Marcelino; Wakelam, Valentine; Roueff, Evelyne; Gratier, Pierre; Marcelino, Núria; Nuñez Reyes, Dianailys; Cernicharo, José; Gerin, Maryvonne

2017-01-01

We report the detection of linear and cyclic isomers of C3H and C3H2 towards various starless cores and review the corresponding chemical pathways involving neutral (C3Hx with x=1,2) and ionic (C3Hx+ with x = 1,2,3) isomers. We highlight the role of the branching ratio of electronic Dissociative Recombination (DR) reactions of C3H2+ and C3H3+ isomers showing that the statistical treatment of the relaxation of C3H* and C3H2* produced in these DR reactions may explain the relative c,l-C3H and c,l-C3H2 abundances. We have also introduced in the model the third isomer of C3H2 (HCCCH). The observed cyclic-to-linear C3H2 ratio vary from 110 ± 30 for molecular clouds with a total density around 1×104 molecules.cm-3 to 30 ± 10 for molecular clouds with a total density around 4×105 molecules.cm-3, a trend well reproduced with our updated model. The higher ratio for low molecular cloud densities is mainly determined by the importance of the H + l-C3H2 → H + c-C3H2 and H + t-C3H2 → H + c-C3H2 isomerization reactions. PMID:29142332

The interstellar chemistry of C3H and C3H2 isomers

NASA Astrophysics Data System (ADS)

Loison, Jean-Christophe; Agúndez, Marcelino; Wakelam, Valentine; Roueff, Evelyne; Gratier, Pierre; Marcelino, Núria; Reyes, Dianailys Nuñez; Cernicharo, José; Gerin, Maryvonne

2017-10-01

We report the detection of linear and cyclic isomers of C3H and C3H2 towards various starless cores and review the corresponding chemical pathways involving neutral (C3Hx with x = 1,2) and ionic (C3Hx+ with x = 1,2,3) isomers. We highlight the role of the branching ratio of electronic dissociative recombination (DR) reactions of C3H2+ and C3H3+ isomers, showing that the statistical treatment of the relaxation of C3H* and C3H2* produced in these DR reactions may explain the relative c,l-C3H and c,l-C3H2 abundances. We have also introduced in the model the third isomer of C3H2 (HCCCH). The observed cyclic-to-linear C3H2 ratio varies from 110 ± 30 for molecular clouds with a total density of about 1 × 104 molecules cm-3 to 30 ± 10 for molecular clouds with a total density of about 4 × 105 molecules cm-3, a trend well reproduced with our updated model. The higher ratio for molecular clouds with low densities is determined mainly by the importance of the H + l-C3H2 → H + c-C3H2 and H + t-C3H2 → H + c-C3H2 isomerization reactions.

Abyssal seafloor waste isolation: the concept

NASA Astrophysics Data System (ADS)

Valent, Philip J.; Young, David K.; Sawyer, William B.; Wright, Thomas D.

1998-05-01

The Naval Research Laboratory (NRL), with industry and university participation, conducted an assessment of the concept of isolating certain wastes (i.e., sewage sludge, fly ash from municipal incinerators, and contaminated dredged material) on the oceans' abyssal seafloor. In this assessment the advantages, disadvantages, and economic and environmental viability of potential engineering methods for achieving abyssal waste isolation were identified and compared. This paper presents background to the Abyssal Plains Waste Isolation (APWI) Project, describes the characteristics of the waste streams and quantities potentially available for disposal via the abyssal isolation concept, summarizes regulations affecting use of the abyssal seafloor for disposal of wastes, and introduces the technical and scientific premises underlying implementation of the concept.

36 CFR 221.3 - Disposal of national forest timber according to management plans.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SERVICE, DEPARTMENT OF AGRICULTURE TIMBER MANAGEMENT PLANNING § 221.3 Disposal of national forest timber... and of opportunities for employment. (4) Provide for coordination of timber production and harvesting...

36 CFR 221.3 - Disposal of national forest timber according to management plans.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SERVICE, DEPARTMENT OF AGRICULTURE TIMBER MANAGEMENT PLANNING § 221.3 Disposal of national forest timber... and of opportunities for employment. (4) Provide for coordination of timber production and harvesting...

ENGINEERED NEAR SURFACE DISPOSAL FACILITY OF THE INDUSTRIAL COMPLEX FOR SOLID RADWASTE MANAGEMENT AT CHERNOBYL NUCLEAR POWER PLANT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziehm, Ronny; Pichurin, Sergey Grigorevich

2003-02-27

As a part of the turnkey project ''Industrial Complex for Solid Radwaste Management (ICSRM) at the Chernobyl Nuclear Power Plant (ChNPP)'' an Engineered Near Surface Disposal Facility (ENSDF, LOT 3) will be built on the VEKTOR site within the 30 km Exclusion Zone of the ChNPP. This will be performed by RWE NUKEM GmbH, Germany, and it governs the design, licensing support, fabrication, assembly, testing, inspection, delivery, erection, installation and commissioning of the ENSDF. The ENSDF will receive low to intermediate level, short lived, processed/conditioned wastes from the ICSRM Solid Waste Processing Facility (SWPF, LOT 2), the ChNPP Liquid Radwastemore » Treatment Plant (LRTP) and the ChNPP Interim Storage Facility for RBMK Fuel Assemblies (ISF). The ENSDF has a capacity of 55,000 m{sup 3}. The primary functions of the ENSDF are: to receive, monitor and record waste packages, to load the waste packages into concrete disposal units, to enable capping and closure of the disposal unit s, to allow monitoring following closure. The ENSDF comprises the turnkey installation of a near surface repository in the form of an engineered facility for the final disposal of LILW-SL conditioned in the ICSRM SWPF and other sources of Chernobyl waste. The project has to deal with the challenges of the Chernobyl environment, the fulfillment of both Western and Ukrainian standards, and the installation and coordination of an international project team. It will be shown that proven technologies and processes can be assembled into a unique Management Concept dealing with all the necessary demands and requirements of a turnkey project. The paper emphasizes the proposed concepts for the ENSDF and their integration into existing infrastructure and installations of the VEKTOR site. Further, the paper will consider the integration of Western and Ukrainian Organizations into a cohesive project team and the requirement to guarantee the fulfillment of both Western standards and

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.

PubMed

Harada, Akihito; Maehara, Kazumitsu; Ono, Yusuke; Taguchi, Hiroyuki; Yoshioka, Kiyoshi; Kitajima, Yasuo; Xie, Yan; Sato, Yuko; Iwasaki, Takeshi; Nogami, Jumpei; Okada, Seiji; Komatsu, Tetsuro; Semba, Yuichiro; Takemoto, Tatsuya; Kimura, Hiroshi; Kurumizaka, Hitoshi; Ohkawa, Yasuyuki

2018-04-11

Regulation of gene expression requires selective incorporation of histone H3 variant H3.3 into chromatin. Histone H3.3 has several subsidiary variants but their functions are unclear. Here we characterize the function of histone H3.3 sub-variant, H3mm7, which is expressed in skeletal muscle satellite cells. H3mm7 knockout mice demonstrate an essential role of H3mm7 in skeletal muscle regeneration. Chromatin analysis reveals that H3mm7 facilitates transcription by forming an open chromatin structure around promoter regions including those of myogenic genes. The crystal structure of the nucleosome containing H3mm7 reveals that, unlike the S57 residue of other H3 proteins, the H3mm7-specific A57 residue cannot form a hydrogen bond with the R40 residue of the cognate H4 molecule. Consequently, the H3mm7 nucleosome is unstable in vitro and exhibited higher mobility in vivo compared with the H3.3 nucleosome. We conclude that the unstable H3mm7 nucleosome may be required for proper skeletal muscle differentiation.

Rate contants for CF{sub 3} + H{sub 2} {yields} CF{sub 3}H + H and CF{sub 3}H + H {yields} CF{sub 3} + H{sub 2} reactions in the temperature range 1100-1600 K.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hranisavljevic, J.; Michael, V.; Chemistry

1998-09-24

The shock tube technique coupled with H-atom atomic resonance absorption spectrometry has been used to study the reactions (1) CF{sub 3} + H{sub 2} {yields} CF{sub 3}H + H and (2) CF{sub 3}H + H{yields} CF{sub 3} + H{sub 2} over the temperature ranges 1168-1673 K and 1111-1550 K, respectively. The results can be represented by the Arrhenius expressions k1 = 2.56 x 10{sup -11} exp(-8549K/T) and k2 = 6.13 x 10{sup -11} exp(-7364K/T), both in cm3 molecule-1 s-1. Equilibrium constants were calculated from the two Arrhenius expressions in the overlapping temperature range, and good agreement was obtained with themore » literature values. The rate constants for reaction 2 were converted into rate constants for reaction 1 using literature equilibrium constants. These data are indistinguishable from direct k1 measurements, and an Arrhenius fit for the joint set is k{sub 1} = 1.88 x 10{sup -11} exp(-8185K/T) cm3 molecule-1 s-1. The CF{sub 3} + H{sub 2} {yields} CF{sub 3}H + H reaction was further modeled using conventional transition-state theory, which included ab initio electronic structure determinations of reactants, transition state, and products.« less

Disposable Electronic Cigarettes and Electronic Hookahs: Evaluation of Performance

PubMed Central

Williams, Monique; Ghai, Sanjay

2015-01-01

Introduction: The purpose of this study was to characterize the performance of disposable button-activated and disposable airflow-activated electronic cigarettes (EC) and electronic hookahs (EH). Methods: The airflow rate required to produce aerosol, pressure drop, and the aerosol absorbance at 420nm were measured during smoke-outs of 9 disposable products. Three units of each product were tested in these experiments. Results: The airflow rates required to produce aerosol and the aerosol absorbances were lower for button-activated models (3mL/s; 0.41–0.55 absorbance) than for airflow-activated models (7–17mL/s; 0.48–0.84 absorbance). Pressure drop was also lower across button-activated products (range = 6–12mm H2O) than airflow-activated products (range = 15–67mm H20). For 25 of 27 units tested, airflow did not have to be increased during smoke-out to maintain aerosol production, unlike earlier generation models. Two brands had uniform performance characteristics for all parameters, while 3 had at least 1 product that did not function normally. While button-activated models lasted 200 puffs or less and EH airflow-activated models often lasted 400 puffs, none of the models produced as many puffs as advertised. Puff number was limited by battery life, which was shorter in button-activated models. Conclusion: The performance of disposable products was differentiated mainly by the way the aerosol was produced (button vs airflow-activated) rather than by product type (EC vs EH). Users needed to take harder drags on airflow-activated models. Performance varied within models, and battery life limited the number of puffs. Data suggest quality control in manufacturing varies among brands. PMID:25104117

Modeling Groundwater Flow and Infiltration at Potential Low-Level Radioactive Waste Disposal Sites in Taiwan

NASA Astrophysics Data System (ADS)

Arnold, B. W.; Lee, C.; Ma, C.; Knowlton, R. G.

2006-12-01

Taiwan is evaluating representative sites for the potential disposal of low-level radioactive waste (LLW), including consideration of shallow land burial and cavern disposal concepts. A representative site for shallow land burial is on a small island in the Taiwan Strait with basalt bedrock. The shallow land burial concept includes an engineered cover to limit infiltration into the waste disposal cell. A representative site for cavern disposal is located on the southeast coast of Taiwan. The tunnel system for this disposal concept would be several hundred meters below the mountainous land surface in argillite bedrock. The LLW will consist of about 966,000 drums, primarily from the operation and decommissioning of four nuclear power plants. Sandia National Laboratories and the Institute of Nuclear Energy Research have collaborated to develop performance assessment models to evaluate the long-term safety of LLW disposal at these representative sites. Important components of the system models are sub-models of groundwater flow in the natural system and infiltration through the engineered cover for the shallow land burial concept. The FEHM software code was used to simulate groundwater flow in three-dimensional models at both sites. In addition, a higher-resolution two-dimensional model was developed to simulate flow through the engineered tunnel system at the cavern site. The HELP software was used to simulate infiltration through the cover at the island site. The primary objective of these preliminary models is to provide a modeling framework, given the lack of site-specific data and detailed engineering design specifications. The steady-state groundwater flow model at the island site uses a specified recharge boundary at the land surface and specified head at the island shoreline. Simulated groundwater flow vectors are extracted from the FEHM model along a cross section through one of the LLW disposal cells for utilization in radionuclide transport simulations in

48 CFR 945.604-1 - Disposal methods.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Disposal methods. 945.604... GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.604-1 Disposal methods. (b)(3) Recovering...) See 945.670 for DOE disposal methods. ...

48 CFR 945.604-1 - Disposal methods.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Disposal methods. 945.604... GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.604-1 Disposal methods. (b)(3) Recovering...) See 945.670 for DOE disposal methods. ...

Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.; Hardin, Ernest

2015-07-01

This report presents conceptual design information for a system to handle and emplace packages containing radioactive waste, in boreholes 16,400 ft deep or possibly deeper. Its intended use is for a design selection study that compares the costs and risks associated with two emplacement methods: drill-string and wireline emplacement. The deep borehole disposal (DBD) concept calls for siting a borehole (or array of boreholes) that penetrate crystalline basement rock to a depth below surface of about 16,400 ft (5 km). Waste packages would be emplaced in the lower 6,560 ft (2 km) of the borehole, with sealing of appropriate portionsmore » of the upper 9,840 ft (3 km). A deep borehole field test (DBFT) is planned to test and refine the DBD concept. The DBFT is a scientific and engineering experiment, conducted at full-scale, in-situ, without radioactive waste. Waste handling operations are conceptualized to begin with the onsite receipt of a purpose-built Type B shipping cask, that contains a waste package. Emplacement operations begin when the cask is upended over the borehole, locked to a receiving flange or collar. The scope of emplacement includes activities to lower waste packages to total depth, and to retrieve them back to the surface when necessary for any reason. This report describes three concepts for the handling and emplacement of the waste packages: 1) a concept proposed by Woodward-Clyde Consultants in 1983; 2) an updated version of the 1983 concept developed for the DBFT; and 3) a new concept in which individual waste packages would be lowered to depth using a wireline. The systems described here could be adapted to different waste forms, but for design of waste packaging, handling, and emplacement systems the reference waste forms are DOE-owned high- level waste including Cs/Sr capsules and bulk granular HLW from fuel processing. Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design July 23, 2015 iv ACKNOWLEDGEMENTS This

40 CFR 721.5540 - 1H,3H,5H-oxazolo [3,4-c] oxazole, dihydro-7a-methyl-.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 1H,3H,5H-oxazolo [3,4-c] oxazole... Specific Chemical Substances § 721.5540 1H,3H,5H-oxazolo [3,4-c] oxazole, dihydro-7a-methyl-. (a) Chemical substances and significant new uses subject to reporting. (1) The chemical substance identified as 1H,3H,5H...

Critical Safe Disposal of Spent Fuel: Behavior of Neutron Poisons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kienzler, Bernhard; Gmal, Bernhard

2007-07-01

In contrast to Yucca Mountain, European repository concepts rely on deep underground conditions which guarantee permanently a reducing geochemical environment. As long as no water comes into contact with the disposed nuclear fuel, criticality is excluded by compliance with the disposal conditions (limitation of U/Pu in the canisters). Penetration of water into the canister may also be considered as a scenario. However, water in a disposal results in geochemical reactions proceeding over very long periods of time: (1) Presence of water allows the corrosion of the steel of the canister material forming hydrogen and iron corrosion products. (2) Hydrogen pressuresmore » affect the zircaloy cladding even at low temperatures. Failure of fuel cladding and spacers leads to changes in the geometrical configuration. (3) UO{sub 2} matrix corrosion results in geochemically controlled reformation of secondary phase. (4) Even if the dissolution rate of UO{sub 2} is low, elements accounting for burnup credit do not behave similar as uranium. Geochemical reactions are analyzed in detail and compositions are presented which have a high probability to be formed in the long-term needing to be analyzed with respect to K{sub eff}. (authors)« less

Rate constants for CF{sub 3} + H{sub 2} {r_arrow} CF{sub 3}H + H and CF{sub 3}H + H {r_arrow} CF{sub 3} + H{sub 2} reactions in the temperature range 1100--1600 K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hranisavljevic, J.; Michael, J.V.

1998-09-24

The shock tube technique coupled with H-atom atomic resonance absorption spectrometry has been used to study the reactions (1) CF{sub 3} + H{sub 2} {r_arrow} CF{sub 3}H + H and (2) CF{sub 3}H + H {r_arrow} CF{sub 3} + H{sub 2} over the temperature ranges 1168--1673 K and 1111--1550 K, respectively. The results can be represented by the Arrhenius expressions k{sub 1} = 2.56 {times} 10{sup {minus}11} exp({minus}8549K/T) and k{sub 2} = 6.13 {times} 10{sup {minus}11} exp({minus}7364K/T), both in cm{sup 3} molecule{sup {minus}1} s{sup {minus}1}. Equilibrium constants were calculated from the two Arrhenius expressions in the overlapping temperature range, andmore » good agreement was obtained with the literature values. The rate constants for reaction 2 were converted into rate constants for reaction 1 using literature equilibrium constants. These data are indistinguishable from direct k{sub 1} measurements, and an Arrhenius fit for the joint set is k{sub 1} = 1.88 {times} 10{sup {minus}11} exp({minus}8185K/T) cm{sup 3} molecule{sup {minus}1} s{sup {minus}1}. The CF{sub 3} + H{sub 2} {r_arrow} CF{sub 3}H + H reaction was further modeled using conventional transition-state theory, which included ab initio electronic structure determinations of reactants, transition state, and products.« less

Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9

PubMed Central

LeRoy, Gary; Bua, Dennis J; Garcia, Benjamin A; Gozani, Or; Richard, Stéphane

2010-01-01

Chromatin is broadly compartmentalized in two defined states: euchromatin and heterochromatin. Generally, euchromatin is trimethylated on histone H3 lysine 4 (H3K4me3) while heterochromatin contains the H3K9me3 mark. The H3K9me3 modification is added by lysine methyltransferases (KMTs) such as SETDB1. Herein, we show that SETDB1 interacts with its substrate H3, but only in the absence of the euchromatic mark H3K4me3. In addition, we show that SETDB1 fails to methylate substrates containing the H3K4me3 mark. Likewise, the functionally related H3K9 KMTs G9A, GLP and SUV39H1 also fail to bind and to methylate H3K4me3 substrates. Accordingly, we provide in vivo evidence that H3K9me2-enriched histones are devoid of H3K4me2/3 and that histones depleted of H3K4me2/3 have elevated H3K9me2/3. The correlation between the loss of interaction of these KMTs with H3K4me3 and concomitant methylation impairment leads to the postulate that at least these four KMTs require stable interaction with their respective substrates for optimal activity. Thus, novel substrates could be discovered via the identification of KMT interacting proteins. Indeed, we find that SETDB1 binds to and methylates a novel substrate, the inhibitor of growth protein ING2, while SUV39H1 binds to and methylates the heterochromatin protein HP1α. Thus, our observations suggest a mechanism of post-translational regulation of lysine methylation and propose a potential mechanism for the segregation of the biologically opposing marks, H3K4me3 and H3K9me3. Furthermore, the correlation between H3-KMTs interaction and substrate methylation highlights that the identification of novel KMT substrates may be facilitated by the identification of interaction partners. PMID:21124070

Toxic-Waste Disposal by Drain-in-Furnace Technique

NASA Technical Reports Server (NTRS)

Compton, L. E.; Stephens, J. B.; Moynihan, P. I.; Houseman, J.; Kalvinskas, J. J.

1986-01-01

Compact furnace moved from site to site. Toxic industrial waste destroyed using furnace concept developed for disposal of toxic munitions. Toxic waste drained into furnace where incinerated immediately. In furnace toxic agent rapidly drained and destroyed in small combustion chamber between upper and lower layers of hot ceramic balls

Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Dan; Hu, Qi; Li, Qing

2013-04-08

Dynamic variations in the structure of chromatin influence virtually all DNA-related processes in eukaryotes and are controlled in part by post-translational modifications of histones. One such modification, the acetylation of lysine 56 (H3K56ac) in the amino-terminal α-helix (αN) of histone H3, has been implicated in the regulation of nucleosome assembly during DNA replication and repair, and nucleosome disassembly during gene transcription. In Saccharomyces cerevisiae, the histone chaperone Rtt106 contributes to the deposition of newly synthesized H3K56ac-carrying H3-H4 complex on replicating DNA, but it is unclear how Rtt106 binds H3-H4 and specifically recognizes H3K56ac as there is no apparent acetylated lysinemore » reader domain in Rtt106. Here, we show that two domains of Rtt106 are involved in a combinatorial recognition of H3-H4. An N-terminal domain homodimerizes and interacts with H3-H4 independently of acetylation while a double pleckstrin-homology (PH) domain binds the K56-containing region of H3. Affinity is markedly enhanced upon acetylation of K56, an effect that is probably due to increased conformational entropy of the αN helix of H3. Our data support a mode of interaction where the N-terminal homodimeric domain of Rtt106 intercalates between the two H3-H4 components of the (H3-H4) 2 tetramer while two double PH domains in the Rtt106 dimer interact with each of the two H3K56ac sites in (H3-H4) 2. We show that the Rtt106-(H3-H4) 2 interaction is important for gene silencing and the DNA damage response.« less

Special Analysis: Disposal of ETF Activated Carbon Vessels in Slit Trenches at the E-Area Low-Level Waste Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collard, L.B.

2003-08-25

This Special Analysis (SA) addresses two contaminants of concern, H-3 and I-129, in three Effluent Treatment Facility (ETF) Activated Carbon Vessels awaiting disposal as solid waste. The Unreviewed Disposal Question (UDQ) evaluation listed two options for disposal of this waste, disposal as Components-in-Grout (CIG) or disposal in Slit Trenches with sealed openings to restrict release of H-3 form the vessels. Consumption of the CIG inventory limit and consumption of CIG facility volume are shown for the ETF vessels to allow easy comparison with the consumption of Slit Trench inventory limit and consumption of the Slit Trench facility volume . Themore » inventory projections are based on doubling the inventory of the three ETF vessels in the E-Area to account for the unknown inventory of three ETF vessels in the ETF. When the grout ultimately is assumed to degrade hydraulically, the water movement is not impeded as much as the release is accelerated by the presence of the grout. Under these conditions for the CIG trenches relative to the Slit Trenches, the well concentrations are higher, the inventory limit is lower and for a given inventory the inventory limit consumption is higher.« less

Inexpensive and Disposable pH Electrodes

ERIC Educational Resources Information Center

Goldcamp, Michael J.; Conklin, Alfred; Nelson, Kimberly; Marchetti, Jessica; Brashear, Ryan; Epure, Emily

2010-01-01

Inexpensive electrodes for the measurement of pH have been constructed using the ionophore tribenzylamine for sensing H[superscript +] concentrations. Both traditional liquid-membrane electrodes and coated-wire electrodes have been constructed and studied, and both exhibit linear, nearly Nernstian responses to changes in pH. Measurements of pH…

Crystalline and Crystalline International Disposal Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Viswanathan, Hari S.; Chu, Shaoping; Dittrich, Timothy M.

This report presents the results of work conducted between September 2015 and July 2016 at Los Alamos National Laboratory in the crystalline disposal and crystalline international disposal work packages of the Used Fuel Disposition Campaign (UFDC) for DOE-NE’s Fuel Cycle Research and Development program. Los Alamos focused on two main activities during this period: Discrete fracture network (DFN) modeling to describe flow and radionuclide transport in complex fracture networks that are typical of crystalline rock environments, and a comprehensive interpretation of three different colloid-facilitated radionuclide transport experiments conducted in a fractured granodiorite at the Grimsel Test Site in Switzerland betweenmore » 2002 and 2013. Chapter 1 presents the results of the DFN work and is divided into three main sections: (1) we show results of our recent study on the correlation between fracture size and fracture transmissivity (2) we present an analysis and visualization prototype using the concept of a flow topology graph for characterization of discrete fracture networks, and (3) we describe the Crystalline International work in support of the Swedish Task Force. Chapter 2 presents interpretation of the colloidfacilitated radionuclide transport experiments in the crystalline rock at the Grimsel Test Site.« less

Interstellar H3+

PubMed Central

Oka, Takeshi

2006-01-01

Protonated molecular hydrogen, H3+, is the simplest polyatomic molecule. It is the most abundantly produced interstellar molecule, next only to H2, although its steady state concentration is low because of its extremely high chemical reactivity. H3+ is a strong acid (proton donor) and initiates chains of ion-molecule reactions in interstellar space thus leading to formation of complex molecules. Here, I summarize the understandings on this fundamental species in interstellar space obtained from our infrared observations since its discovery in 1996 and discuss the recent observations and analyses of H3+ in the Central Molecular Zone near the Galatic center that led to a revelation of a vast amount of warm and diffuse gas existing in the region. PMID:16894171

Development of rotorcraft interior noise control concepts. Phase 3: Development of noise control concepts

NASA Technical Reports Server (NTRS)

Yoerkie, Charles A.; Gintoli, P. J.; Ingraham, S. T.; Moore, J. A.

1986-01-01

The goal of this research is the understanding of helicopter internal noise mechanisms and the development, design, and testing of noise control concepts which will produce significant reductions in the acoustic environment to which passengers are exposed. The Phase 3 effort involved the identification and evaluation of current and advanced treatment concepts, including isolation of structure-borne paths. In addition, a plan was devised for the full-scale evaluation of an isolation concept. Specific objectives were as follows: (1) identification and characterization of various noise control concepts; (2) implementation of noise control concepts within the S-76 SEA (statistical energy analysis) model; (3) definition and evaluation of a preliminary acoustic isolation design to reduce structure-borne transmission of acoustic frequency main gearbox gear clash vibrations into the airframe; (4) formulation of a plan for the full-scale validation of the isolation concept; and (5) prediction of the cabin noise environment with various noise control concepts installed.

Executive Summary of Ares V: Lunar Capabilities Concept Review Through Phase A-Cycle 3

NASA Technical Reports Server (NTRS)

Holladay, J. B.; Baggett, K. E.; Feldman, S. M.

2011-01-01

This Technical Memorandum (TM) was generated as an overall Ares V summary from the Lunar Capabilities Concept Review (LCCR) through Phase A-Cycle 3 (PA-C3) with the intent that it may be coupled with separately published appendices for a more detailed, integrated narrative. The Ares V has evolved from the initial point of departure (POD) 51.00.48 LCCR configuration to the current candidate POD, PA-C3D, and the family of vehicles concept that contains vehicles PA-C3A through H. The logical progression from concept to POD vehicles is summarized in this TM and captures the trade space and performance of each. The family-of-vehicles concept was assessed during PA-C3 and offered flexibility in the path forward with the ability to add options deemed appropriate. A description of each trade space is given in addition to a summary of each Ares V element. The Ares V contributions to a Mars campaign are also highlighted with the goal of introducing Ares V capabilities within the trade space. The assessment of the Ares V vehicle as it pertains to Mars missions remained locked to the architecture presented in Mars Design Reference Authorization 5.0 using the PA-C3D vehicle configuration to assess Mars transfer vehicle options, in-space EDS capabilities, docking adaptor and propellant transfer assessments, and lunar and Mars synergistic potential.

A feasibility assessment of nuclear reactor power system concepts for the NASA Growth Space Station

NASA Technical Reports Server (NTRS)

Bloomfield, H. S.; Heller, J. A.

1986-01-01

A preliminary feasibility assessment of the integration of reactor power system concepts with a projected growth Space Station architecture was conducted to address a variety of installation, operational, disposition and safety issues. A previous NASA sponsored study, which showed the advantages of Space Station - attached concepts, served as the basis for this study. A study methodology was defined and implemented to assess compatible combinations of reactor power installation concepts, disposal destinations, and propulsion methods. Three installation concepts that met a set of integration criteria were characterized from a configuration and operational viewpoint, with end-of-life disposal mass identified. Disposal destinations that met current aerospace nuclear safety criteria were identified and characterized from an operational and energy requirements viewpoint, with delta-V energy requirement as a key parameter. Chemical propulsion methods that met current and near-term application criteria were identified and payload mass and delta-V capabilities were characterized. These capabilities were matched against concept disposal mass and destination delta-V requirements to provide a feasibility of each combination.

Disposal of Chemotherapeutic Agent -- Contaminated Waste

DTIC Science & Technology

1989-03-01

RESTRICTIVE MARKINGS 2a SECURITY CLASSIFICATION AUTHORITY 3 . DISTRIBUTION/AVAILABILITY OF REPORT 2b. DECLASSIFICATION/DOWNGRADING SCHEDULE Approved for Public...AIR .............. 22 INCINERATION SYSTEM 2 CHEMOTHERAPEUTIC WASTE THERMAL ...... 32 DESTRUCTION DISPOSAL SYSTEM 3 FRONT VIEW OF INCINERATION...The Environmental Protection Agency has published a manual (Reference 1) which provides guidelines on handling and 3 disposal of infectious waste from

U.S. program assessing nuclear waste disposal in space - A 1981 status report

NASA Technical Reports Server (NTRS)

Rice, E. E.; Edgecombe, D. S.; Best, R. E.; Compton, P. R.

1982-01-01

Concepts, current studies, and technology and equipment requirements for using the STS for space disposal of selected nuclear wastes as a complement to geological storage are reviewed. An orbital transfer vehicle carried by the Shuttle would kick the waste cannister into a 0.85 AU heliocentric orbit. One flight per week is regarded as sufficient to dispose of all high level wastes chemically separated from reactor fuel rods from 200 GWe nuclear power capacity. Studies are proceeding for candidate wastes, the STS system suited to each waste, and the risk/benefits of a space disposal system. Risk assessments are being extended to total waste disposal risks for various disposal programs with and without a space segment, and including side waste streams produced as a result of separating substances for launch.

Differential binding of /sup 3/H-imipramine and /sup 3/H-mianserin in rat cerebral cortex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dumbrille-Ross, A.; Tang, S.W.; Coscina, D.V.

1981-11-16

Drug competition profiles, effect of raphe lesion, and sodium dependency of the binding of two antidepressant drugs /sup 3/H-imipramine and /sup 3/H-mianserin to rat cerebral cortex homogenate were compared to examine whether the drugs bound to a common ''antidepressant receptor.'' Of the neurotransmitters tested, only serotonin displaced binding of both /sup 3/H-imipramine and /sup 3/H-mianserin. /sup 3/H-Mianserin binding was potently displaced by serotonin S/sub 2/ antagonists and exhibited a profile similar to that of /sup 3/H-spiperone binding. In the presence of the serotonin S/sub 2/ antagonist spiperone, antihistamines (H/sub 1/) potently displaced /sup 3/H-mianserin binding. /sup 3/H-Imipramine binding was displacedmore » potently by serotonin uptake inhibitors. The order of potency of serotonergic drugs in displacing /sup 3/H-imipramine binding was not similar to their order in displacing /sup 3/H-spiperone or -3H-serotonin binding. Prior midbrain raphe lesions greatly decreased the binding of /sup 3/H-imipramine but did not alter binding of /sup 3/H-mianserin. Binding of /sup 3/H-imipramine but not /sup 3/H-mianserin was sodium dependent. These results show that /sup 3/H-imipramine and /sup 3/H-mianserin bind to different receptors. /sup 3/H-Imipramine binds to a presynaptic serotonin receptor which is probably related to a serotonin uptake recognition site, the binding of which is sodium dependent. /sup 3/H-Mianserin binds to postsynaptic receptors, possibly both serotonin S/sub 2/ and histamine H/sub 1/ receptors, the binding of which is sodium independent.« less

Argillite And Crystalline Disposal Research: Accomplishments And Path-Forward.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, Kevin A.; Jove-Colon, Carlos F.; Wang, Yifeng

The intention of this document is to provide a path-forward for research and development (R&D) for two host rock media-specific (argillite and crystalline) disposal research work packages within the Used Fuel Disposition Campaign (UFDC). The two work packages, Argillite Disposal R&D and Crystalline Disposal R&D, support the achievement of the overarching mission and objectives of the Department of Energy Office of Nuclear Energy Fuel Cycle Technologies Program. These two work packages cover many of the fundamental technical issues that will have multiple implications to other disposal research work packages by bridging knowledge gaps to support the development of the safetymore » case. The path-forward begins with the assumption of target dates that are set out in the January 2013 DOE Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (http://energy.gov/downloads/strategy-management-and-disposal-used-nuclear-fuel-and-high-levelradioactive- waste). The path-forward will be maintained as a living document and will be updated as needed in response to available funding and the progress of multiple R&D tasks in the Used Fuel Disposition Campaign and the Fuel Cycle Technologies Program. This path forward is developed based on the report of “Used Fuel Disposition Campaign Disposal Research and Development Roadmap (FCR&D-USED- 2011-000065 REV0)” (DOE, 2011). This document delineates the goals and objectives of the UFDC R&D program, needs for generic disposal concept design, and summarizes the prioritization of R&D issues.« less

Deep Borehole Disposal Safety Analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freeze, Geoffrey A.; Stein, Emily; Price, Laura L.

This report presents a preliminary safety analysis for the deep borehole disposal (DBD) concept, using a safety case framework. A safety case is an integrated collection of qualitative and quantitative arguments, evidence, and analyses that substantiate the safety, and the level of confidence in the safety, of a geologic repository. This safety case framework for DBD follows the outline of the elements of a safety case, and identifies the types of information that will be required to satisfy these elements. At this very preliminary phase of development, the DBD safety case focuses on the generic feasibility of the DBD concept.more » It is based on potential system designs, waste forms, engineering, and geologic conditions; however, no specific site or regulatory framework exists. It will progress to a site-specific safety case as the DBD concept advances into a site-specific phase, progressing through consent-based site selection and site investigation and characterization.« less

48 CFR 34.005-3 - Concept exploration contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Concept exploration... SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.005-3 Concept exploration contracts. Whenever practicable, contracts to be performed during the concept exploration phase shall be for...

Breast Cancer Detection by B7-H3-Targeted Ultrasound Molecular Imaging.

PubMed

Bachawal, Sunitha V; Jensen, Kristin C; Wilson, Katheryne E; Tian, Lu; Lutz, Amelie M; Willmann, Jürgen K

2015-06-15

Ultrasound complements mammography as an imaging modality for breast cancer detection, especially in patients with dense breast tissue, but its utility is limited by low diagnostic accuracy. One emerging molecular tool to address this limitation involves contrast-enhanced ultrasound using microbubbles targeted to molecular signatures on tumor neovasculature. In this study, we illustrate how tumor vascular expression of B7-H3 (CD276), a member of the B7 family of ligands for T-cell coregulatory receptors, can be incorporated into an ultrasound method that can distinguish normal, benign, precursor, and malignant breast pathologies for diagnostic purposes. Through an IHC analysis of 248 human breast specimens, we found that vascular expression of B7-H3 was selectively and significantly higher in breast cancer tissues. B7-H3 immunostaining on blood vessels distinguished benign/precursors from malignant lesions with high diagnostic accuracy in human specimens. In a transgenic mouse model of cancer, the B7-H3-targeted ultrasound imaging signal was increased significantly in breast cancer tissues and highly correlated with ex vivo expression levels of B7-H3 on quantitative immunofluorescence. Our findings offer a preclinical proof of concept for the use of B7-H3-targeted ultrasound molecular imaging as a tool to improve the diagnostic accuracy of breast cancer detection in patients. ©2015 American Association for Cancer Research.

10 CFR 61.51 - Disposal site design for land disposal.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Disposal site design for land disposal. 61.51 Section 61.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.51 Disposal site design for land...

10 CFR 61.51 - Disposal site design for land disposal.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Disposal site design for land disposal. 61.51 Section 61.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.51 Disposal site design for land...

10 CFR 61.51 - Disposal site design for land disposal.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Disposal site design for land disposal. 61.51 Section 61.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.51 Disposal site design for land...

10 CFR 61.51 - Disposal site design for land disposal.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Disposal site design for land disposal. 61.51 Section 61.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.51 Disposal site design for land...

10 CFR 61.51 - Disposal site design for land disposal.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Disposal site design for land disposal. 61.51 Section 61.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.51 Disposal site design for land...

Advances in poultry litter disposal technology--a review.

PubMed

Kelleher, B P; Leahy, J J; Henihan, A M; O'Dwyer, T F; Sutton, D; Leahy, M J

2002-05-01

The land disposal of waste from the poultry industry and subsequent environmental implications has stimulated interest into cleaner and more useful disposal options. The review presented here details advances in the three main alternative disposal routes for poultry litter, specifically in the last decade. Results of experimental investigations into the optimisation of composting, anaerobic digestion and direct combustion are summarised. These technologies open up increased opportunities to market the energy and nutrients in poultry litter to agricultural and non-agricultural uses. Common problems experienced by the current technologies are the existence and fate of nitrogen as ammonia, pH and temperature levels, moisture content and the economics of alternative disposal methods. Further advancement of these technologies is currently receiving increased interest, both academically and commercially. However, significant financial incentives are required to attract the agricultural industry.

48 CFR 245.603 - Disposal methods.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Disposal methods. 245.603 Section 245.603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Contractor Inventory 245.603 Disposal methods. ...

Engineering risk assessment for emergency disposal projects of sudden water pollution incidents.

PubMed

Shi, Bin; Jiang, Jiping; Liu, Rentao; Khan, Afed Ullah; Wang, Peng

2017-06-01

Without an engineering risk assessment for emergency disposal in response to sudden water pollution incidents, responders are prone to be challenged during emergency decision making. To address this gap, the concept and framework of emergency disposal engineering risks are reported in this paper. The proposed risk index system covers three stages consistent with the progress of an emergency disposal project. Fuzzy fault tree analysis (FFTA), a logical and diagrammatic method, was developed to evaluate the potential failure during the process of emergency disposal. The probability of basic events and their combination, which caused the failure of an emergency disposal project, were calculated based on the case of an emergency disposal project of an aniline pollution incident in the Zhuozhang River, Changzhi, China, in 2014. The critical events that can cause the occurrence of a top event (TE) were identified according to their contribution. Finally, advices on how to take measures using limited resources to prevent the failure of a TE are given according to the quantified results of risk magnitude. The proposed approach could be a potential useful safeguard for the implementation of an emergency disposal project during the process of emergency response.

Advances in Geologic Disposal System Modeling and Application to Crystalline Rock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mariner, Paul E.; Stein, Emily R.; Frederick, Jennifer M.

The Used Fuel Disposition Campaign (UFDC) of the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Office of Fuel Cycle Technology (OFCT) is conducting research and development (R&D) on geologic disposal of used nuclear fuel (UNF) and high-level nuclear waste (HLW). Two of the high priorities for UFDC disposal R&D are design concept development and disposal system modeling (DOE 2011). These priorities are directly addressed in the UFDC Generic Disposal Systems Analysis (GDSA) work package, which is charged with developing a disposal system modeling and analysis capability for evaluating disposal system performance for nuclear waste in geologic mediamore » (e.g., salt, granite, clay, and deep borehole disposal). This report describes specific GDSA activities in fiscal year 2016 (FY 2016) toward the development of the enhanced disposal system modeling and analysis capability for geologic disposal of nuclear waste. The GDSA framework employs the PFLOTRAN thermal-hydrologic-chemical multi-physics code and the Dakota uncertainty sampling and propagation code. Each code is designed for massively-parallel processing in a high-performance computing (HPC) environment. Multi-physics representations in PFLOTRAN are used to simulate various coupled processes including heat flow, fluid flow, waste dissolution, radionuclide release, radionuclide decay and ingrowth, precipitation and dissolution of secondary phases, and radionuclide transport through engineered barriers and natural geologic barriers to the biosphere. Dakota is used to generate sets of representative realizations and to analyze parameter sensitivity.« less

The radioactivity estimation of 14C and 3H in graphite waste samples of the KRR-2.

PubMed

Reyoung Kim, Hee

2013-09-01

The radioactivity of (14)C and (3)H in graphite samples from the dismantled Korea Research Reactor-2 (the KRR-2) site was analyzed by high-temperature oxidation and liquid scintillation counting, and the graphite waste was suggested to be disposed of as a low-level radioactive waste. The graphite samples were oxidized at a high temperature of 800 °C, and their counting rates were measured by using a liquid scintillation counter (LSC). The combustion ratio of the graphite was about 99% on the sample with a maximum weight of 1g. The recoveries from the combustion furnace were around 100% and 90% in (14)C and (3)H, respectively. The minimum detectable activity was 0.04-0.05 Bq/g for the (14)C and 0.13-0.15 Bq/g for the (3)H at the same background counting time. The activity of (14)C was higher than that of (3)H over all samples with the activity ratios of the (14)C to (3)H, (14)C/(3)H, being between 2.8 and 25. The dose calculation was carried out from its radioactivity analysis results. The dose estimation gave a higher annual dose than the domestic legal limit for a clearance. It was thought that the sampled graphite waste from the dismantled research reactor was not available for reuse or recycling and should be monitored as low-level radioactive waste. Copyright © 2013 Elsevier Ltd. All rights reserved.

26 CFR 1.631-3 - Gain or loss upon the disposal of coal or domestic iron ore with a retained economic interest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... domestic iron ore with a retained economic interest. 1.631-3 Section 1.631-3 Internal Revenue INTERNAL...) Sales and Exchanges § 1.631-3 Gain or loss upon the disposal of coal or domestic iron ore with a... disposes of coal (including lignite), or iron ore mined in the United States, held for more than 1 year (6...

26 CFR 1.631-3 - Gain or loss upon the disposal of coal or domestic iron ore with a retained economic interest.

Code of Federal Regulations, 2012 CFR

2012-04-01

... domestic iron ore with a retained economic interest. 1.631-3 Section 1.631-3 Internal Revenue INTERNAL...) Sales and Exchanges § 1.631-3 Gain or loss upon the disposal of coal or domestic iron ore with a... disposes of coal (including lignite), or iron ore mined in the United States, held for more than 1 year (6...

26 CFR 1.631-3 - Gain or loss upon the disposal of coal or domestic iron ore with a retained economic interest.

Code of Federal Regulations, 2011 CFR

2011-04-01

... domestic iron ore with a retained economic interest. 1.631-3 Section 1.631-3 Internal Revenue INTERNAL...) Sales and Exchanges § 1.631-3 Gain or loss upon the disposal of coal or domestic iron ore with a... disposes of coal (including lignite), or iron ore mined in the United States, held for more than 1 year (6...

26 CFR 1.631-3 - Gain or loss upon the disposal of coal or domestic iron ore with a retained economic interest.

Code of Federal Regulations, 2013 CFR

2013-04-01

... domestic iron ore with a retained economic interest. 1.631-3 Section 1.631-3 Internal Revenue INTERNAL...) Sales and Exchanges § 1.631-3 Gain or loss upon the disposal of coal or domestic iron ore with a... disposes of coal (including lignite), or iron ore mined in the United States, held for more than 1 year (6...

26 CFR 1.631-3 - Gain or loss upon the disposal of coal or domestic iron ore with a retained economic interest.

Code of Federal Regulations, 2014 CFR

2014-04-01

... domestic iron ore with a retained economic interest. 1.631-3 Section 1.631-3 Internal Revenue INTERNAL...) Sales and Exchanges § 1.631-3 Gain or loss upon the disposal of coal or domestic iron ore with a... disposes of coal (including lignite), or iron ore mined in the United States, held for more than 1 year (6...

H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements

PubMed Central

Zink, Lisa-Maria; Delbarre, Erwan; Eberl, H. Christian; Keilhauer, Eva C.; Bönisch, Clemens; Pünzeler, Sebastian; Bartkuhn, Marek; Collas, Philippe; Mann, Matthias

2017-01-01

Abstract Histone chaperones prevent promiscuous histone interactions before chromatin assembly. They guarantee faithful deposition of canonical histones and functionally specialized histone variants into chromatin in a spatial- and temporally-restricted manner. Here, we identify the binding partners of the primate-specific and H3.3-related histone variant H3.Y using several quantitative mass spectrometry approaches, and biochemical and cell biological assays. We find the HIRA, but not the DAXX/ATRX, complex to recognize H3.Y, explaining its presence in transcriptionally active euchromatic regions. Accordingly, H3.Y nucleosomes are enriched in the transcription-promoting FACT complex and depleted of repressive post-translational histone modifications. H3.Y mutational gain-of-function screens reveal an unexpected combinatorial amino acid sequence requirement for histone H3.3 interaction with DAXX but not HIRA, and for H3.3 recruitment to PML nuclear bodies. We demonstrate the importance and necessity of specific H3.3 core and C-terminal amino acids in discriminating between distinct chaperone complexes. Further, chromatin immunoprecipitation sequencing experiments reveal that in contrast to euchromatic HIRA-dependent deposition sites, human DAXX/ATRX-dependent regions of histone H3 variant incorporation are enriched in heterochromatic H3K9me3 and simple repeat sequences. These data demonstrate that H3.Y's unique amino acids allow a functional distinction between HIRA and DAXX binding and its consequent deposition into open chromatin. PMID:28334823

Nanocrystalline ZnCO3-A novel sorbent for low-temperature removal of H2S.

PubMed

Balichard, Kevin; Nyikeine, Camille; Bezverkhyy, Igor

2014-01-15

The reactivity of a nanocrystalline ZnCO3 toward H2S (0.2vol% in N2/H2 mixture) at 140-180°C was characterized by thermal gravimetric analysis and by breakthrough curves measurements. We have found that under used conditions transformation of ZnCO3 into ZnS is complete and the rate determining step of the sulfidation is the surface reaction. Such behavior is in strike contrast with that of ZnO whose sulfidation is severely limited by diffusion. The higher reactivity of ZnCO3 in comparison with ZnO is attributed to the different microstructure of ZnS layer formed in these materials after a partial sulfidation. As in ZnO-ZnS transformation the molar volume increases (from 14.5 to 23.8cm(3)/mol), a continuous protective ZnS layer is formed hampering the access of H2S to the non reacted ZnO core. By contrast, in ZnCO3-ZnS transformation the molar volume decreases (from 27.9 to 23.8cm(3)/mol), which produces a discontinuous non-protective ZnS layer enabling a complete transformation of ZnCO3 even at 140°C. The higher reactivity of ZnCO3 results in a considerable increase of the breakthrough sulfur capacity of the carbonate in comparison with oxide. The material has therefore a good potential for being used as a disposable sorbent for H2S capture at low temperature. Copyright © 2013 Elsevier B.V. All rights reserved.

Properties of the pressure-induced superconducting state in trihydrides ScH3 and LaH3

NASA Astrophysics Data System (ADS)

Durajski, A. P.; Szczȩśniak, R.

2014-11-01

The present paper discusses the thermodynamic properties of the superconducting state which gets induced in the following compounds due to the influence of the high pressure: ScH3 ( p = 18 GPa) and LaH3 (p = 11 GPa). Using the Eliashberg formalism, for the Coulomb pseudopotential equal to 0.1, the following quantities have been determined: the maximum critical temperature ({{[{{T}C}]}Sc{{H3}}}=19.3 K and {{[{{T}C}]}La{{H3}}}=22.5 K), the energy gap at the Fermi surface (G), the free energy (F), the thermodynamic critical field (HC), and the specific heat (both for the superconducting (CS) and the normal (CN) state). Then, the dimensionless parameters, namely, {{R}G}\\equiv G≤ft( 0 \\right)/{{k}B}{{T}C}, {{R}H}\\equiv {{T}C}{{C}N}≤ft( {{T}C} \\right)/HC2≤ft( 0 \\right), and {{R}C}\\equiv ≤ft( {{C}S}≤ft( {{T}C} \\right)-{{C}N}≤ft( {{T}C} \\right) \\right)/{{C}N}≤ft( {{T}C} \\right), have been obtained. Those ratios deviate from the predictions of the BCS theory in the case of the studied compounds: {{[{{R}G}]}Sc{{H3}}}=3.85, {{[{{R}G}]}La{{H3}}}=3.92, {{[{{R}H}]}Sc{{H3}}}=0.160, {{[{{R}H}]}La{{H3}}}=0.154, {{[{{R}C}]}Sc{{H3}}}=1.84, and {{[{{R}C}]}La{{H3}}}=2.09. In the last step, it has been proven that the ratio of the electron effective mass (me\\star ) to the electron band mass (me) takes relatively high values, which are weakly dependent on the temperature. For example, it has been shown that {{[me\\star /{{m}e}]}Sc{{H3}}}=1.833 and {{[me\\star /{{m}e}]}La{{H3}}}=1.845 for T={{T}C}.

Summary of International Waste Management Programs (LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenberg, Harris R.; Blink, James A.; Halsey, William G.

2011-08-11

The Used Fuel Disposition Campaign (UFDC) within the Department of Energy’s Office of Nuclear Energy (DOE-NE) Fuel Cycle Technology (FCT) program has been tasked with investigating the disposal of the nation’s spent nuclear fuel (SNF) and high-level nuclear waste (HLW) for a range of potential waste forms and geologic environments. This Lessons Learned task is part of a multi-laboratory effort, with this LLNL report providing input to a Level 3 SNL milestone (System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW). The work package number is: FTLL11UF0328; the work package title is: Technical Bases / Lessons Learned;more » the milestone number is: M41UF032802; and the milestone title is: “LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW”. The system-wide integration effort will integrate all aspects of waste management and disposal, integrating the waste generators, interim storage, transportation, and ultimate disposal at a repository site. The review of international experience in these areas is required to support future studies that address all of these components in an integrated manner. Note that this report is a snapshot of nuclear power infrastructure and international waste management programs that is current as of August 2011, with one notable exception. No attempt has been made to discuss the currently evolving world-wide response to the tragic consequences of the earthquake and tsunami that devastated Japan on March 11, 2011, leaving more than 15,000 people dead and more than 8,000 people missing, and severely damaging the Fukushima Daiichi nuclear power complex. Continuing efforts in FY 2012 will update the data, and summarize it in an Excel spreadsheet for easy comparison and assist in the knowledge management of the study cases.« less

18 CFR 401.32 - Concept of 3.8.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Concept of 3.8. 401.32 Section 401.32 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact § 401.32 Concept...

18 CFR 401.32 - Concept of 3.8.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Concept of 3.8. 401.32 Section 401.32 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact § 401.32 Concept...

3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKenna, D.J.; Guan, X.M.; Shulgin, A.T.

1991-03-01

The effect of various analogues of the neurotoxic amphetamine derivative, MDA (3,4-methylenedioxyamphetamine) on carrier-mediated, calcium-independent release of 3H-5-HT and 3H-DA from rat brain synaptosomes was investigated. Both enantiomers of the neurotoxic analogues MDA and MDMA (3,4-methylenedioxymethamphetamine) induce synaptosomal release of 3H-5-HT and 3H-DA in vitro. The release of 3H-5-HT induced by MDMA is partially blocked by 10(-6) M fluoxetine. The (+) enantiomers of both MDA and MDMA are more potent than the (-) enantiomers as releasers of both 3H-5-HT and 3H-DA. Eleven analogues, differing from MDA with respect to the nature and number of ring and/or side chain substituents, alsomore » show some activity in the release experiments, and are more potent as releasers of 3H-5-HT than of 3H-DA. The amphetamine derivatives {plus minus}fenfluramine, {plus minus}norfenfluramine, {plus minus}MDE, {plus minus}PCA, and d-methamphetamine are all potent releasers of 3H-5-HT and show varying degrees of activity as 3H-DA releasers. The hallucinogen DOM does not cause significant release of either 3H-monoamine. Possible long-term serotonergic neurotoxicity was assessed by quantifying the density of 5-HT uptake sites in rats treated with multiple doses of selected analogues using 3H-paroxetine to label 5-HT uptake sites. In the neurotoxicity study of the compounds investigated, only (+)MDA caused a significant loss of 5-HT uptake sites in comparison to saline-treated controls. These results are discussed in terms of the apparent structure-activity properties affecting 3H-monoamine release and their possible relevance to neurotoxicity in this series of MDA congeners.« less

10 CFR 61.50 - Disposal site suitability requirements for land disposal.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Disposal site suitability requirements for land disposal. 61.50 Section 61.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.50 Disposal site...

10 CFR 61.50 - Disposal site suitability requirements for land disposal.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Disposal site suitability requirements for land disposal. 61.50 Section 61.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.50 Disposal site...

10 CFR 61.50 - Disposal site suitability requirements for land disposal.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Disposal site suitability requirements for land disposal. 61.50 Section 61.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.50 Disposal site...

10 CFR 61.50 - Disposal site suitability requirements for land disposal.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Disposal site suitability requirements for land disposal. 61.50 Section 61.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.50 Disposal site...

10 CFR 61.50 - Disposal site suitability requirements for land disposal.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Disposal site suitability requirements for land disposal. 61.50 Section 61.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Technical Requirements for Land Disposal Facilities § 61.50 Disposal site...

Multi-centre evaluation of two daily disposable contact lenses.

PubMed

Walker, Jon; Young, Graeme; Hunt, Chris; Henderson, Terri

2007-05-01

To evaluate the clinical performance of two daily disposable contact lenses: 1-DAY ACUVUE (1DA) (etafilcon A, Johnson & Johnson Vision Care) and FOCUS DAILIES with AquaComfort (FD) (nelfilcon A, CIBA Vision, Inc.), which contains a quickly released moisture enhancing agent, polyvinyl alcohol (PVA). This was a 1-week, daily wear, subject-masked, bilateral, parallel group study with subjects randomly assigned to one of two daily disposable soft contact lenses. Subjects were existing soft contact lens wearers in the age range 18-39 years with a spherical refraction between -0.50 and -6.00 D. Subjects were assessed at baseline and after 1 week. Assessments included both subjective (symptoms, wearing time, vision) and objective (lens fit and ocular health) outcomes. Twenty clinical sites enrolled 282 subjects (74% female) of whom 276 (98%) successfully completed the study. Significantly more 1DA wearers reported higher mean comfort scores than with FD (3.95 versus 3.41, respectively, P<0.0001). End-of-day comfort means were also significantly higher with the 1DA group compared to the FD group (3.3 versus 3.0, P=0.03). The 1DA group reported significantly longer mean overall wearing time (1DA was worn on average 0.66+/-0.30 h longer than FD, P=0.03) and longer mean comfortable wearing time (1DA was worn on average 1.73+/-0.35 h longer than FD, P<0.0001). The 1DA lens generally showed significantly better on-eye fitting in terms of movement in primary (P<0.0001) and upgaze (P<0.0001) and ease of removal from the eye (92% versus 63%, P<0.0001) compared to FD. There was significantly less corneal staining observed with the 1DA wearing eyes compared with the FD wearing eyes (23% versus 45%, respectively, P<0.0001). Finally, there was a weak correlation between corneal staining and comfort for FD (r=0.27, P=0.002, n=136), but not for 1DA (r=-0.11, P=0.18, n=140). Subjective and objective clinical performance differences between two commonly used daily disposable lenses

CAF-1-induced oligomerization of histones H3/H4 and mutually exclusive interactions with Asf1 guide H3/H4 transitions among histone chaperones and DNA

PubMed Central

Liu, Wallace H.; Roemer, Sarah C.; Port, Alex M.; Churchill, Mair E. A.

2012-01-01

Anti-silencing function 1 (Asf1) and Chromatin Assembly Factor 1 (CAF-1) chaperone histones H3/H4 during the assembly of nucleosomes on newly replicated DNA. To understand the mechanism of histone H3/H4 transfer among Asf1, CAF-1 and DNA from a thermodynamic perspective, we developed and employed biophysical approaches using full-length proteins in the budding yeast system. We find that the C-terminal tail of Asf1 enhances the interaction of Asf1 with CAF-1. Surprisingly, although H3/H4 also enhances the interaction of Asf1 with the CAF-1 subunit Cac2, H3/H4 forms a tight complex with CAF-1 exclusive of Asf1, with an affinity weaker than Asf1–H3/H4 or H3/H4–DNA interactions. Unlike Asf1, monomeric CAF-1 binds to multiple H3/H4 dimers, which ultimately promotes the formation of (H3/H4)2 tetramers on DNA. Thus, transition of H3/H4 from the Asf1-associated dimer to the DNA-associated tetramer is promoted by CAF-1-induced H3/H4 oligomerization. PMID:23034810

Potential Size of and Value Proposition for H2@Scale Concept

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth, Mark F; Jadun, Paige; Pivovar, Bryan S

The H2@Scale concept is focused on developing hydrogen as an energy carrier and using hydrogen's properties to improve the national energy system. Specifically hydrogen has the abilities to (1) supply a clean energy source for industry and transportation and (2) increase the profitability of variable renewable electricity generators such as wind turbines and solar photovoltaic (PV) farms by providing value for otherwise potentially-curtailed electricity. Thus the concept also has the potential to reduce oil dependency by providing a low-carbon fuel for fuel cell electric vehicles (FCEVs), reduce emissions of carbon dioxide and pollutants such as NOx, and support domestic energymore » production, manufacturing, and U.S. economic competitiveness. The analysis reported here focuses on the potential market size and value proposition for the H2@Scale concept. It involves three analysis phases: 1. Initial phase estimating the technical potential for hydrogen markets and the resources required to meet them; 2. National-scale analysis of the economic potential for hydrogen and the interactions between willingness to pay by hydrogen users and the cost to produce hydrogen from various sources; and 3. In-depth analysis of spatial and economic issues impacting hydrogen production and utilization and the markets. Preliminary analysis of the technical potential indicates that the technical potential for hydrogen use is approximately 60 million metric tons (MMT) annually for light duty FCEVs, heavy duty vehicles, ammonia production, oil refining, biofuel hydrotreating, metals refining, and injection into the natural gas system. The technical potential of utility-scale PV and wind generation independently are much greater than that necessary to produce 60 MMT / year hydrogen. Uranium, natural gas, and coal reserves are each sufficient to produce 60 MMT / year hydrogen in addition to their current uses for decades to centuries. National estimates of the economic potential of

Disposable condenser humidifiers in intensive care.

PubMed

Oh, T E; Thompson, W R; Hayward, D R

1981-11-01

Two disposable condenser humidifiers were evaluated in nine ventilated intensive care patients. The Portex "Humid Vent" delivered end-inspired absolute humidities of 22--26.3 g/m3 at end-inspired temperatures of 27--28.3 degrees C. Corresponding humidities and temperatures with the Servo "Humidifier 150" were higher and were constant, at 27.7--29 g/m3 and 29.3--29.7 degrees C respectively. These disposable devices can be used for humidification in intensive care, but only for patients breathing room air, or on a short term basis.

Histone H3.3 maintains genome integrity during mammalian development

PubMed Central

Jang, Chuan-Wei; Shibata, Yoichiro; Starmer, Joshua; Yee, Della; Magnuson, Terry

2015-01-01

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans and has been implicated in many important biological processes, including cell differentiation and reprogramming. Germline and somatic mutations in H3.3 genomic incorporation pathway components or in H3.3 encoding genes have been associated with human congenital diseases and cancers, respectively. However, the role of H3.3 in mammalian development remains unclear. To address this question, we generated H3.3-null mouse models through classical genetic approaches. We found that H3.3 plays an essential role in mouse development. Complete depletion of H3.3 leads to developmental retardation and early embryonic lethality. At the cellular level, H3.3 loss triggers cell cycle suppression and cell death. Surprisingly, H3.3 depletion does not dramatically disrupt gene regulation in the developing embryo. Instead, H3.3 depletion causes dysfunction of heterochromatin structures at telomeres, centromeres, and pericentromeric regions of chromosomes, leading to mitotic defects. The resulting karyotypical abnormalities and DNA damage lead to p53 pathway activation. In summary, our results reveal that an important function of H3.3 is to support chromosomal heterochromatic structures, thus maintaining genome integrity during mammalian development. PMID:26159997

Disposal methods

NASA Technical Reports Server (NTRS)

Friedlander, Alan

1991-01-01

A number of disposal options for space nuclear reactors and the associated risks, mostly in the long term, based on probabilities of Earth reentry are discussed. The results are based on a five year study that was conducted between 1978 and 1983 on the space disposal of high level nuclear waste. The study provided assessment of disposal options, stability of disposal or storage orbits, and assessment of the long term risks of Earth reentry of the nuclear waste.

Tailoring of the care concept for practicality, safety and robustness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawamura, Hideki; McKinley, Ian G

2013-07-01

The Cavern Retrievable (CARE) concept was originally developed to provide flexibility in tailoring disposal of vitrified HLW to small volunteer host sites, where high emplacement density leads to significant challenges in terms of the management of radiogenic heat. Including an extended storage period in underground caverns prior to sealing solved the heat issue, but also provided benefits in terms of a slow decision-making process that provided more opportunities to engage stakeholders. Recently, direct disposal of spent fuel is being considered in Japan and this gives more severe challenges for heat management, even for conventional disposal concepts. Due to great uncertaintiesmore » in the future of nuclear power in Japan, this may also be associated with a desire to preserve the option of retrieval for extended periods. The basic CARE concept has thus been re-assessed to consider these aspects - and also the need to be able to develop a robust safety case that can be readily communicated to stakeholders, who are more sensitive to nuclear issues than they were in the past. (authors)« less

Modeling Approach for Estimating Co-Produced Water Volumes and Saltwater Disposal Volumes in Oklahoma

NASA Astrophysics Data System (ADS)

Murray, K. E.

2016-12-01

Management of produced fluids has become an important issue in Oklahoma because large volumes of saltwater are co-produced with oil and gas, and disposed into saltwater disposal wells at high rates. Petroleum production increased from 2009-2015, especially in central and north-central Oklahoma where the Mississippian and Hunton zones were redeveloped using horizontal wells and dewatering techniques that have led to a disproportional increase in produced water volumes. Improved management of co-produced water, including desalination for beneficial reuse and decreased saltwater disposal volumes, is only possible if spatial and temporal trends can be defined and related to the producing zones. It is challenging to quantify the volumes of co-produced water by region or production zone because co-produced water volumes are generally not reported. Therefore, the goal of this research is to estimate co-produced water volumes for 2008-present with an approach that can be replicated as petroleum production shifts to other regions. Oil and gas production rates from subsurface zones were multiplied by ratios of H2O:oil and H2O:gas for the respective zones. Initial H2O:oil and H2O:gas ratios were adjusted/calibrated, by zone, to maximize correlation of county-scale produced H2O estimates versus saltwater disposal volumes from 2013-2015. These calibrated ratios were then used to compute saltwater disposal volumes from 2008-2012 because of apparent data gaps in reported saltwater disposal volumes during that timeframe. This research can be used to identify regions that have the greatest need for produced water treatment systems. The next step in management of produced fluids is to explore optimal energy-efficient strategies that reduce deleterious effects.

Visible light active photocatalyst from recycled disposable heating pads

NASA Astrophysics Data System (ADS)

Lee, Meng-Chien; Wang, Chun-Yu; Chen, Che-Chin; Wang, Chih-Ming; Hsiao, Ta-Chih; Tsai, Din Ping

2016-01-01

Alpha-Fe2O3 (α-Fe2O3) is cheap and abundant and has potential to be a highly efficient photocatalyst for water splitting. According to the report, there are a huge amount of disposable heating pads being created every year, and the pads are used one time then thrown away. We found that the main product of used heating pads is α-Fe2O3. Here, we collect and purify the α-Fe2O3 powder in the used heating pads using low power consumption processes. It is shown that the recycled heating pads can be used as a cost-effective photocatalyst for H2 energy and for decomposition of organic pollutants as well. Additionally, the plasmonic enhanced photocatalysis reaction of α-Fe2O3 is also investigated. It is found that H2 evolution rate can be enhanced 15% using α-Fe2O3 nanoparticles coated with a thin Au layer. The degradation of methylene blue can also enhance 12% compared to photocatalyst α-Fe2O3 nanoparticles coated without Au layer.

3-Methyl-7-(2-thienyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione: pi-stacked bilayers built from N-H...O, C-H...O and C-H...pi hydrogen bonds.

PubMed

Trilleras, Jorge; Quiroga, Jairo; Cobo, Justo; Glidewell, Christopher

2009-06-01

In the title compound, C(12)H(9)N(3)O(2)S, the thienyl substituent is disordered over two sets of sites with occupancies of 0.749 (3) and 0.251 (3). A combination of N-H...O, C-H...O and C-H...pi hydrogen bonds links the molecules into bilayers and these bilayers are themselves linked into a continuous structure by pi-pi stacking interactions.

Why consider subseabed disposal of high-level nuclear waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heath, G. R.; Hollister, C. D.; Anderson, D. R.

1980-01-01

Large areas of the deep seabed warrant assessment as potential disposal sites for high-level radioactive waste because: (1) they are far from seismically and tectonically active lithospheric plate boundaries; (2) they are far from active or young volcanos; (3) they contain thick layers of very uniform fine-grained clays; (4) they are devoid of natural resources likely to be exploited in the forseeable future; (5) the geologic and oceanographic processes governing the deposition of sediments in such areas are well understood, and are remarkably insensitive to past oceanographic and climatic changes; and (6) sedmentary records of tens of millions of yearsmore » of slow, uninterrupted deposition of fine grained clay support predictions of the future stability of such sites. Data accumulated to date on the permeability, ion-retardation properties, and mechanical strength of pelagic clay sediments indicate that they can act as a primary barrier to the escape of buried nuclides. Work in progress should determine within the current decade whether subseabed disposal is environmentally acceptable and technically feasible, as well as address the legal, political and social issues raised by this new concept.« less

45 CFR 671.12 - Waste disposal.

Code of Federal Regulations, 2014 CFR

2014-10-01

... chloride (PVC), polyurethane foam, polystyrene foam, rubber and lubricating oils, treated timbers and other... onto ice-free areas or into any fresh water system. (h) Open burning of wastes is prohibited at all... dispose of waste by open burning prior to March 1, 1994, allowance shall be made for the wind direction...

45 CFR 671.12 - Waste disposal.

Code of Federal Regulations, 2013 CFR

2013-10-01

... chloride (PVC), polyurethane foam, polystyrene foam, rubber and lubricating oils, treated timbers and other... onto ice-free areas or into any fresh water system. (h) Open burning of wastes is prohibited at all... dispose of waste by open burning prior to March 1, 1994, allowance shall be made for the wind direction...

45 CFR 671.12 - Waste disposal.

Code of Federal Regulations, 2011 CFR

2011-10-01

... chloride (PVC), polyurethane foam, polystyrene foam, rubber and lubricating oils, treated timbers and other... onto ice-free areas or into any fresh water system. (h) Open burning of wastes is prohibited at all... dispose of waste by open burning prior to March 1, 1994, allowance shall be made for the wind direction...

45 CFR 671.12 - Waste disposal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... chloride (PVC), polyurethane foam, polystyrene foam, rubber and lubricating oils, treated timbers and other... onto ice-free areas or into any fresh water system. (h) Open burning of wastes is prohibited at all... dispose of waste by open burning prior to March 1, 1994, allowance shall be made for the wind direction...

45 CFR 671.12 - Waste disposal.

Code of Federal Regulations, 2012 CFR

2012-10-01

... chloride (PVC), polyurethane foam, polystyrene foam, rubber and lubricating oils, treated timbers and other... onto ice-free areas or into any fresh water system. (h) Open burning of wastes is prohibited at all... dispose of waste by open burning prior to March 1, 1994, allowance shall be made for the wind direction...

Used Fuel Disposal in Crystalline Rocks. FY15 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yifeng

2015-08-20

The objective of the Crystalline Disposal R&D Work Package is to advance our understanding of long-term disposal of used fuel in crystalline rocks and to develop necessary experimental and computational capabilities to evaluate various disposal concepts in such media. Chapter headings are as follows: Fuel matrix degradation model and its integration with performance assessments, Investigation of thermal effects on the chemical behavior of clays, Investigation of uranium diffusion and retardation in bentonite, Long-term diffusion of U(VI) in bentonite: dependence on density, Sorption and desorption of plutonium by bentonite, Dissolution of plutonium intrinsic colloids in the presence of clay and asmore » a function of temperature, Laboratory investigation of colloid-facilitated transport of cesium by bentonite colloids in a crystalline rock system, Development and demonstration of discrete fracture network model, Fracture continuum model and its comparison with discrete fracture network model.« less

Knowledge-Based Manufacturing and Structural Design for a High Speed Civil Transport

NASA Technical Reports Server (NTRS)

Marx, William J.; Mavris, Dimitri N.; Schrage, Daniel P.

1994-01-01

The aerospace industry is currently addressing the problem of integrating manufacturing and design. To address the difficulties associated with using many conventional procedural techniques and algorithms, one feasible way to integrate the two concepts is with the development of an appropriate Knowledge-Based System (KBS). The authors present their reasons for selecting a KBS to integrate design and manufacturing. A methodology for an aircraft producibility assessment is proposed, utilizing a KBS for manufacturing process selection, that addresses both procedural and heuristic aspects of designing and manufacturing of a High Speed Civil Transport (HSCT) wing. A cost model is discussed that would allow system level trades utilizing information describing the material characteristics as well as the manufacturing process selections. Statements of future work conclude the paper.

9 CFR 315.3 - Disposal of products passed for cooking if not handled according to this part.

Code of Federal Regulations, 2010 CFR

2010-01-01

... cooking if not handled according to this part. 315.3 Section 315.3 Animals and Animal Products FOOD SAFETY... OF CARCASSES AND PARTS PASSED FOR COOKING § 315.3 Disposal of products passed for cooking if not handled according to this part. Products passed for cooking if not handled and processed in accordance...

A mass spectrometric study of gaseous H4PO+3 and H2PO-3 ions

NASA Astrophysics Data System (ADS)

de Petris, Giulia; Occhiucci, Giorgio; Pepi, Federico

1994-09-01

H4PO+3 ions have been generated in a mass spectrometer by proton-transfer to H3PO3 from different Brønsted acids. The proton affinity of H3PO3 has been estimated by bracketing and kinetic methods to be 198.6 ± 2 kcal mol-1. Gaseous H4PO+3 ions have been structurally assessed by metastable ion kinetic energy (MIKE) and collisionally induced dissociation (CID) mass spectrometry leading to the detection of a single isomeric species. The chemistry of H2PO-3 is characterized by facile addition-elimination reactions leading to formation of polyanions. Species containing up to six P atoms have been detected.

Concept for Mars Volcanic Emission Life Scout 3-D Artist Concept

NASA Image and Video Library

2004-12-21

This artist rendition depicts a concept for a Mars orbiter that would scrutinize the martian atmosphere for chemical traces of life or environments supportive of life that might be present anywhere on the planet. 3D glasses are necessary.

Anoxic Biodegradation of Isosaccharinic Acids at Alkaline pH by Natural Microbial Communities.

PubMed

Rout, Simon P; Charles, Christopher J; Doulgeris, Charalampos; McCarthy, Alan J; Rooks, Dave J; Loughnane, J Paul; Laws, Andrew P; Humphreys, Paul N

2015-01-01

One design concept for the long-term management of the UK's intermediate level radioactive wastes (ILW) is disposal to a cementitious geological disposal facility (GDF). Under the alkaline (10.0H>13.0) anoxic conditions expected within a GDF, cellulosic wastes will undergo chemical hydrolysis. The resulting cellulose degradation products (CDP) are dominated by α- and β-isosaccharinic acids (ISA), which present an organic carbon source that may enable subsequent microbial colonisation of a GDF. Microcosms established from neutral, near-surface sediments demonstrated complete ISA degradation under methanogenic conditions up to pH 10.0. Degradation decreased as pH increased, with β-ISA fermentation more heavily influenced than α-ISA. This reduction in degradation rate was accompanied by a shift in microbial population away from organisms related to Clostridium sporosphaeroides to a more diverse Clostridial community. The increase in pH to 10.0 saw an increase in detection of Alcaligenes aquatilis and a dominance of hydrogenotrophic methanogens within the Archaeal population. Methane was generated up to pH 10.0 with acetate accumulation at higher pH values reflecting a reduced detection of acetoclastic methanogens. An increase in pH to 11.0 resulted in the accumulation of ISA, the absence of methanogenesis and the loss of biomass from the system. This study is the first to demonstrate methanogenesis from ISA by near surface microbial communities not previously exposed to these compounds up to and including pH 10.0.

Metabolism of D-[1-3H]glucose, D-[2-3H]glucose, D-[5-3H]glucose, D-[6-3H]glucose and D-[U-14C]glucose by rat and human erythrocytes incubated in the presence of H2O or D2O.

PubMed

Conget, I; Malaisse, W J

1995-02-01

The present study investigates whether heavy water affects the efficiency of 3HOH production from D-[1-3H]glucose, D-[2-3H]glucose, D-[5-3H]glucose and D-[6-3H]glucose relative to the total generation of tritiated metabolites produced by either rat or human erythrocytes. The relative 3HOH yield was close to 95% with D-[5-3H]glucose, 72% with D-[2-3H]glucose, 22-32% with D-[1-3H]glucose, and only 12% with D-[6-3H]glucose. In the latter case, the comparison of the specific radioactivity of intracellular and extracellular acidic metabolites, expressed relative to that of 14C-labelled metabolites produced from D-[U-14C]glucose, indicated that the generation of 3HOH from D-[6-3H]glucose occurs at distal metabolic steps, such as the partial reversion of the pyruvate kinase reaction or the interconversion of pyruvate and L-alanine in the reaction catalysed by glutamate-pyruvate transaminase. As a rule, the substitution of H2O by D2O only caused minor to negligible changes in the relative 3HOH yield. This implies that the unexpectedly high deuteration of 13C-labelled D-glucose metabolites recently documented in erythrocytes exposed to D2O cannot be attributed to any major interference of heavy water with factors regulating both the deuteration and detritiation efficiency, such as the enzyme-to-enzyme tunnelling of specific glycolytic intermediates.

Geological Disposal of Radioactive Waste: A Long-Term Socio-Technical Experiment.

PubMed

Schröder, Jantine

2016-06-01

In this article we investigate whether long-term radioactive waste management by means of geological disposal can be understood as a social experiment. Geological disposal is a rather particular technology in the way it deals with the analytical and ethical complexities implied by the idea of technological innovation as social experimentation, because it is presented as a technology that ultimately functions without human involvement. We argue that, even when the long term function of the 'social' is foreseen to be restricted to safeguarding the functioning of the 'technical', geological disposal is still a social experiment. In order to better understand this argument and explore how it could be addressed, we elaborate the idea of social experimentation with the notion of co-production and the analytical tools of delegation, prescription and network as developed by actor-network theory. In doing so we emphasize that geological disposal inherently involves relations between surface and subsurface, between humans and nonhumans, between the social, material and natural realm, and that these relations require recognition and further elaboration. In other words, we argue that geological disposal concurrently is a social and a technical experiment, or better, a long-term socio-technical experiment. We end with proposing the idea of 'actor-networking' as a sensitizing concept for future research into what geological disposal as a socio-technical experiment could look like.

Synthesis ofN-(2-chloro-5-methylthiophenyl)-N'-(3-methyl-thiophenyl)-N'-[3H3]methylguanidine, l brace [3H3]CNS-5161 r brace

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibbs, Andrew R.; Morimoto, Hiromi; VanBrocklin, Henry F.

2001-09-28

The preparation of the title compound, [{sup 3}H{sub 3}]CNS-5161, was accomplished in three steps starting with the production of [{sup 3}H{sub 3}]iodomethane (CT{sub 3}I). The intermediate N-[{sup 3}H{sub 3}]methyl-3-(thiomethylphenyl)cyanamide was prepared in 77% yield by the addition of CT{sub 3}I to 3-(thiomethylphenyl)cyanamide, previously treated with sodium hydride. Reaction of this tritiated intermediate with 2-chloro-5-thiomethylaniline hydrochloride formed the guanidine compound [{sup 3}H{sub 3}]CNS-5161. Purification by HPLC gave the desired labeled product in an overall yield of 9% with greater than 96% radiochemical purity and a final specific activity of 66 Ci mmol{sup -1}.

A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor

NASA Astrophysics Data System (ADS)

Bihar, Eloїse; Deng, Yingxin; Miyake, Takeo; Saadaoui, Mohamed; Malliaras, George G.; Rolandi, Marco

2016-06-01

Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and is printed on paper. ADH and its cofactor nicotinamide adenine dinucleotide (NAD+) are immobilized onto the OECT with an electrolyte gel. When the OECT-breathalyzer is exposed to ethanol vapor, the enzymatic reaction of ADH and ethanol transforms NAD+ into NADH, which causes a decrease in the OECT source drain current. In this fashion, the OECT-breathalyzer easily detects ethanol in the breath equivalent to BAC from 0.01% to 0.2%. The use of a printed OECT may contribute to the development of breathalyzers that are disposable, ecofriendly, and integrated with wearable devices for real-time BAC monitoring.

A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor

PubMed Central

Bihar, Eloїse; Deng, Yingxin; Miyake, Takeo; Saadaoui, Mohamed; Malliaras, George G.; Rolandi, Marco

2016-01-01

Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and is printed on paper. ADH and its cofactor nicotinamide adenine dinucleotide (NAD+) are immobilized onto the OECT with an electrolyte gel. When the OECT-breathalyzer is exposed to ethanol vapor, the enzymatic reaction of ADH and ethanol transforms NAD+ into NADH, which causes a decrease in the OECT source drain current. In this fashion, the OECT-breathalyzer easily detects ethanol in the breath equivalent to BAC from 0.01% to 0.2%. The use of a printed OECT may contribute to the development of breathalyzers that are disposable, ecofriendly, and integrated with wearable devices for real-time BAC monitoring. PMID:27291059

Chemical Stockpile Disposal Program. Transportation of Chemical Agents and Munitions. A Concept Plan.

DTIC Science & Technology

1987-06-30

one of the disposal alternatives now under study by the U.S. Army for...departure, established Army procedures and Army-sponsored studies on safety and security practices and on the handling and transportation of chemical agents...Statement published by the Army in July 1986. As part of the public commentary on this document, requests were made of the Army to consider also the

Direct disposal of spent fuel: developing solutions tailored to Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawamura, Hideki; McKinley, Ian G

2013-07-01

With the past Government policy of 100% reprocessing in Japan now open to discussion, options for direct disposal of spent fuel (SF) are now being considered in Japan. The need to move rapidly ahead in developing spent fuel management concepts is closely related to the ongoing debate on the future of nuclear power in Japan and the desire to understand the true costs of the entire life cycle of different options. Different scenarios for future nuclear power - and associated decisions on extent of reprocessing - will give rise to quite different inventories of SF with different disposal challenges. Althoughmore » much work has been carried out spent fuel disposal within other national programmes, the potential for mining the international knowledge base is limited by the boundary conditions for disposal in Japan. Indeed, with a volunteer approach to siting, no major salt deposits and few undisturbed sediments, high tectonic activity, relatively corrosive groundwater and no deserts, it is evident that a tailored solution is needed. Nevertheless, valuable lessons can be learned from projects carried out worldwide, if focus is placed on basic principles rather than implementation details. (authors)« less

MIMO-OFDM for a Cellular Deployment - Concepts, Real-Time Implementation and Measurements Towards 3GPP-LTE

DTIC Science & Technology

2007-09-01

CONCEPTS, REAL-TIME IMPLEMENTATION AND MEASUREMENTS TOWARDS 3GPP-LTE T. Haustein , J. Eichinger, W. Zirwas, E. Schulz Nokia Siemens...BER (bottom) in an office scenario while the UE is moved from one room to another. REFERENCES [1] V. Jungnickel, A. Forck, T. Haustein , C. Juchems...2.12.2006 [3] T. Haustein , A. Forck, H. Gäbler, V. Jungnickel and S. Schif- fermüller, „Real-Time Experiments on Channel Adaptive Transmis- sion in

Reaction paths in the system Al 2O 3-hBN-Y

NASA Astrophysics Data System (ADS)

Reichert, K.; Oreshina, O.; Cremer, R.; Neuschütz, D.

2001-07-01

As part of the investigations on the suitability of a new concept for a tailored fiber-matrix interface in sapphire fiber reinforced NiAl matrix composites for application as a high-temperature structural material, the interfacial reactions in the system alumina-hexagonal boron nitride-yttrium (Al 2O 3-hBN-Y) have been examined in the temperature range of 1100-1300°C. For this, alumina substrates were coated with hBN by means of CVD and subsequently with sputter deposited yttrium. Afterwards the samples were annealed for up to 16 h under inert atmosphere. Grazing incidence X-ray diffraction (GIXRD) served to analyze the phases formed by diffusion processes in the reaction zone. The peak intensities in these diffraction patterns were used to evaluate the sequence of phases formed due to diffusion and reaction. After the initial formation of YN and YB 2, the phases Y 2O 3, Al 2Y, and YB 4 were observed. Even longer annealing times or higher temperatures, respectively, led to the formation of the ternary oxides YAlO 3 and Y 3Al 5O 12 as well as metallic aluminum.

10 CFR 20.2008 - Disposal of certain byproduct material.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Disposal of certain byproduct material. 20.2008 Section 20.2008 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Waste Disposal § 20.2008 Disposal of certain byproduct material. (a) Licensed material as defined in paragraphs (3...

10 CFR 20.2008 - Disposal of certain byproduct material.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Disposal of certain byproduct material. 20.2008 Section 20.2008 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Waste Disposal § 20.2008 Disposal of certain byproduct material. (a) Licensed material as defined in paragraphs (3...

10 CFR 20.2008 - Disposal of certain byproduct material.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Disposal of certain byproduct material. 20.2008 Section 20.2008 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Waste Disposal § 20.2008 Disposal of certain byproduct material. (a) Licensed material as defined in paragraphs (3...

10 CFR 20.2008 - Disposal of certain byproduct material.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Disposal of certain byproduct material. 20.2008 Section 20.2008 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Waste Disposal § 20.2008 Disposal of certain byproduct material. (a) Licensed material as defined in paragraphs (3...

10 CFR 20.2008 - Disposal of certain byproduct material.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Disposal of certain byproduct material. 20.2008 Section 20.2008 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Waste Disposal § 20.2008 Disposal of certain byproduct material. (a) Licensed material as defined in paragraphs (3...

Comparison of three commercial knowledge bases for detection of drug-drug interactions in clinical decision support.

PubMed

Fung, Kin Wah; Kapusnik-Uner, Joan; Cunningham, Jean; Higby-Baker, Stefanie; Bodenreider, Olivier

2017-07-01

To compare 3 commercial knowledge bases (KBs) used for detection and avoidance of potential drug-drug interactions (DDIs) in clinical practice. Drugs in the DDI tables from First DataBank (FDB), Micromedex, and Multum were mapped to RxNorm. The KBs were compared at the clinical drug, ingredient, and DDI rule levels. The KBs were evaluated against a reference list of highly significant DDIs from the Office of the National Coordinator for Health Information Technology (ONC). The KBs and the ONC list were applied to a prescription data set to simulate their use in clinical decision support. The KBs contained 1.6 million (FDB), 4.5 million (Micromedex), and 4.8 million (Multum) clinical drug pairs. Altogether, there were 8.6 million unique pairs, of which 79% were found only in 1 KB and 5% in all 3 KBs. However, there was generally more agreement than disagreement in the severity rankings, especially in the contraindicated category. The KBs covered 99.8-99.9% of the alerts of the ONC list and would have generated 25 (FDB), 145 (Micromedex), and 84 (Multum) alerts per 1000 prescriptions. The commercial KBs differ considerably in size and quantity of alerts generated. There is less variability in severity ranking of DDIs than suggested by previous studies. All KBs provide very good coverage of the ONC list. More work is needed to standardize the editorial policies and evidence for inclusion of DDIs to reduce variation among knowledge sources and improve relevance. Some DDIs considered contraindicated in all 3 KBs might be possible candidates to add to the ONC list. Published by Oxford University Press on behalf of the American Medical Informatics Association 2017. This work is written by US Government employees and is in the public domain in the United States.

Development of quantitative methods for the detection of enteroviruses in sewage sludges during activation and following land disposal.

PubMed Central

Hurst, C J; Farrah, S R; Gerba, C P; Melnick, J L

1978-01-01

The development and evaluation of methods for the quantitative recovery of enteroviruses from sewage sludge are reported. Activated sewage sludge solids were collected by centrifugation, and elution of the solid-associated virus was accomplished by mechanical agitation in glycine buffer at pH 11.0. Eluted viruses were concentrated either onto an aluminum hydroxide floc or by association with a floc which formed de novo upon adjustment of the glycine eluate to pH 3.5. Viruses which remained in the liquid phase after lowering the pH of glycine eluate were concentrated by adsorption to and elution from membrane filters. The method of choice included high pH glycine elution and subsequent low pH concentration; it yielded an efficiency of recovery from activated sludge of 80% for poliovirus type 1, 68% for echovirus type 7, and 75% for coxsackievirus B3. This method was used to study the survival of naturally occurring virus in sludge at a sewage treatment plant and after subsequent land disposal of the solids after aerobic digestion. Reduction of enterovirus titers per gram (dry weight) of solids were modest during sludge activation but increased to a rate of 2 log 10/week after land disposal. PMID:29559

Development of quantitative methods for the detection of enteroviruses in sewage sludges during activation and following land disposal.

PubMed

Hurst, C J; Farrah, S R; Gerba, C P; Melnick, J L

1978-07-01

The development and evaluation of methods for the quantitative recovery of enteroviruses from sewage sludge are reported. Activated sewage sludge solids were collected by centrifugation, and elution of the solid-associated virus was accomplished by mechanical agitation in glycine buffer at pH 11.0. Eluted viruses were concentrated either onto an aluminum hydroxide floc or by association with a floc which formed de novo upon adjustment of the glycine eluate to pH 3.5. Viruses which remained in the liquid phase after lowering the pH of glycine eluate were concentrated by adsorption to and elution from membrane filters. The method of choice included high pH glycine elution and subsequent low pH concentration; it yielded an efficiency of recovery from activated sludge of 80% for poliovirus type 1, 68% for echovirus type 7, and 75% for coxsackievirus B3. This method was used to study the survival of naturally occurring virus in sludge at a sewage treatment plant and after subsequent land disposal of the solids after aerobic digestion. Reduction of enterovirus titers per gram (dry weight) of solids were modest during sludge activation but increased to a rate of 2 log 10/week after land disposal.

The astrochemistry of H+3

NASA Astrophysics Data System (ADS)

Herbst, E.

2000-09-01

The reactions of the molecular ion H3+ are pivotal to the chemistry of dense interstellar clouds. Produced by the cosmic-ray ionizati on of molecular hydrogen, H3+ reacts with a variety of a toms and molecules to produce species that are precursors to many of the detect ed molecules in dense clouds. For example, the reaction of H3+ with atomic O leads, eventually, to the production of water, while the re action with HD leads to the production of a wide variety of deuterated isotopom ers. In this article, the chemistry of H3+ and the produc ts derived from it are discussed in the larger context of interstellar chemistr y.

H3K27me3 and H3K4me3 chromatin environment at super-induced dehydration stress memory genes of Arabidopsis thaliana.

PubMed

Liu, Ning; Fromm, Michael; Avramova, Zoya

2014-03-01

Pre-exposure to a stress may alter the plant's cellular, biochemical, and/or transcriptional responses during future encounters as a 'memory' from the previous stress. Genes increasing transcription in response to a first dehydration stress, but producing much higher transcript levels in a subsequent stress, represent the super-induced 'transcription memory' genes in Arabidopsis thaliana. The chromatin environment (histone H3 tri-methylations of Lys 4 and Lys 27, H3K4me3, and H3K27me3) studied at five dehydration stress memory genes revealed existence of distinct memory-response subclasses that responded differently to CLF deficiency and displayed different transcriptional activities during the watered recovery periods. Among the most important findings is the novel aspect of the H3K27me3 function observed at specific dehydration stress memory genes. In contrast to its well-known role as a chromatin repressive mechanism at developmentally regulated genes, H3K27me3 did not prevent transcription from the dehydration stress-responding genes. The high H3K27me3 levels present during transcriptionally inactive states did not interfere with the transition to active transcription and with H3K4me3 accumulation. H3K4me3 and H3K27me3 marks function independently and are not mutually exclusive at the dehydration stress-responding memory genes.

Comparison of (/sup 3/H)pirenzepine and (/sup 3/H)quinuclidinylbenzilate binding to muscarinic cholinergic receptors in rat brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luthin, G.R.; Wolfe, B.B.

The properties of (/sup 3/H)quinuclidinylbenzilate ( (/sup 3/H)QNB) binding and (/sup 3/H)pirenzepine ( (/sup 3/H)PZ) binding to various regions of rat brain were compared. (/sup 3/H)PZ appeared to bind with high affinity to a single site, with a Kd value of approximately 15 nM in the cerebral cortex. The rank order of potencies of muscarinic drugs to inhibit binding of either (/sup 3/H)QNB or (/sup 3/H)PZ was QNB greater than atropine . scopolamine greater than pirenzepine greater than oxotremorine greater than bethanechol. Muscarinic antagonists (except PZ) inhibited both (/sup 3/H)PZ and (/sup 3/H)QNB binding with Hill coefficients of approximately 1.more » PZ inhibited (/sup 3/H)QNB binding in cortex with a Hill coefficient of 0.7, but inhibited (/sup 3/H)PZ binding with a Hill coefficient of 1.0. Hill coefficients for agonists were less than 1. The density of (/sup 3/H)PZ binding sites was approximately half the density of (/sup 3/H)QNB binding sites in cortex, striatum and hippocampus. In pons-medulla and cerebellum, the densities of (/sup 3/H)PZ binding sites were 20 and 0%, respectively, relative to the densities of (/sup 3/H)QNB binding sites. When unlabeled PZ was used to compete for (/sup 3/H)QNB binding, the relative number of high-affinity PZ binding sites in cortex, pons and cerebellum agreed with the relative number of (/sup 3/H)PZ binding sites in those regions. The binding of (/sup 3/H)PZ and (/sup 3/H)QNB was nonadditive in cortex. GTP inhibited high-affinity oxotremorine binding, but not PZ binding. Together, these data suggest that (/sup 3/H)PZ binds to a subset of (/sup 3/H)QNB binding sites. Whether this subset reflects the existence of subtypes of muscarinic receptors or is a consequence of coupling to another membrane protein remains to be seen.« less

Unsafe disposal of feces of children <3 years among households with latrine access in rural Bangladesh: Association with household characteristics, fly presence and child diarrhea

PubMed Central

Ercumen, Ayse; Ashraf, Sania; Rahman, Mahbubur; Shoab, Abul K.; Luby, Stephen P.; Unicomb, Leanne

2018-01-01

Background Young children frequently defecate in the living environment in low-income countries. Unsafe child feces disposal has been associated with risk of diarrhea. Additionally, reported practices can underestimate socially undesirable unhygienic behaviors. This analysis aimed to assess (1) the sensitivity of reported child feces disposal practices as an indicator for observed presence of human feces in the domestic environment, (2) household characteristics associated with reported unsafe feces disposal and (3) whether unsafe feces disposal is associated with fly presence and diarrhea among children <3 years. Methods We recorded caregiver-reported feces disposal practices for children <3 years; unsafe disposal was defined as feces put/rinsed into a drain, ditch, bush or garbage heap or left on the ground and safe disposal as feces put/rinsed into latrine or specific pit or buried. We conducted spot checks for human feces, counted flies in the compound and recorded caregiver-reported child diarrhea prevalence among 803 rural Bangladeshi households. We assessed associations using generalized estimating equations (GEE) and generalized linear models (GLM) with robust standard errors. Results Unsafe disposal of child feces was reported by 80% of households. Reported disposal practices had high sensitivity (91%) but low positive predictive value (15%) as an indicator of observed feces in the compound. Unsafe disposal was more common among households that reported daily adult open defecation (PR: 1.13, 1.02–1.24) and had children defecating in a nappy or on the ground versus in a potty (PR: 2.92, 1.98–4.32), and less common in households where adults reported always defecating in latrines (PR: 0.91, 0.84–0.98). The presence of observed human feces was similarly associated with these household characteristics. Reported unsafe feces disposal or observed human feces were not associated with fly detection or child diarrhea. Conclusion Despite access to on

Disposable soft 3 axis force sensor for biomedical applications.

PubMed

Chathuranga, Damith Suresh; Zhongkui Wang; Yohan Noh; Nanayakkara, Thrishantha; Hirai, Shinichi

2015-08-01

This paper proposes a new disposable soft 3D force sensor that can be used to calculate either force or displacement and vibrations. It uses three Hall Effect sensors orthogonally placed around a cylindrical beam made of silicon rubber. A niobium permanent magnet is inside the silicon. When a force is applied to the end of the cylinder, it is compressed and bent to the opposite side of the force displacing the magnet. This displacement causes change in the magnetic flux around the ratiomatric linear sensors (Hall Effect sensors). By analysing these changes, we calculate the force or displacement in three directions using a lookup table. This sensor can be used in minimal invasive surgery and haptic feedback applications. The cheap construction, bio-compatibility and ease of miniaturization are few advantages of this sensor. The sensor design, and its characterization are presented in this work.

Site Selection and Geological Research Connected with High Level Waste Disposal Programme in the Czech Republic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomas, J.

2003-02-25

Attempts to solve the problem of high-level waste disposal including the spent fuel from nuclear power plants have been made in the Czech Republic for over the 10 years. Already in 1991 the Ministry of Environment entitled The Czech Geological Survey to deal with the siting of the locality for HLW disposal and the project No. 3308 ''The geological research of the safe disposal of high level waste'' had started. Within this project a sub-project ''A selection of perspective HLW disposal sites in the Bohemian Massif'' has been elaborated and 27 prospective areas were identified in the Czech Republic. Thismore » selection has been later narrowed to 8 areas which are recently studied in more detail. As a parallel research activity with siting a granitic body Melechov Massif in Central Moldanubian Pluton has been chosen as a test site and the 1st stage of research i.e. evaluation and study of its geological, hydrogeological, geophysical, tectonic and structural properties has been already completed. The Melechov Massif was selected as a test site after the recommendation of WATRP (Waste Management Assessment and Technical Review Programme) mission of IAEA (1993) because it represents an area analogous with the host geological environment for the future HLW and spent fuel disposal in the Czech Republic, i.e. variscan granitoids. It is necessary to say that this site would not be in a locality where the deep repository will be built, although it is a site suitable for oriented research for the sampling and collection of descriptive data using up to date and advanced scientific methods. The Czech Republic HLW and spent fuel disposal programme is now based on The Concept of Radioactive Waste and Spent Nuclear Fuel Management (''Concept'' hereinafter) which has been prepared in compliance with energy policy approved by Government Decree No. 50 of 12th January 2000 and approved by the Government in May 2002. Preparation of the Concept was required, amongst other reasons in

Enhanced LOD Concepts for Virtual 3d City Models

NASA Astrophysics Data System (ADS)

Benner, J.; Geiger, A.; Gröger, G.; Häfele, K.-H.; Löwner, M.-O.

2013-09-01

Virtual 3D city models contain digital three dimensional representations of city objects like buildings, streets or technical infrastructure. Because size and complexity of these models continuously grow, a Level of Detail (LoD) concept effectively supporting the partitioning of a complete model into alternative models of different complexity and providing metadata, addressing informational content, complexity and quality of each alternative model is indispensable. After a short overview on various LoD concepts, this paper discusses the existing LoD concept of the CityGML standard for 3D city models and identifies a number of deficits. Based on this analysis, an alternative concept is developed and illustrated with several examples. It differentiates between first, a Geometric Level of Detail (GLoD) and a Semantic Level of Detail (SLoD), and second between the interior building and its exterior shell. Finally, a possible implementation of the new concept is demonstrated by means of an UML model.

49 CFR 599.201 - Identification of salvage auctions and disposal facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... facilities. 599.201 Section 599.201 Transportation Other Regulations Relating to Transportation (Continued... and Disposal Facilities § 599.201 Identification of salvage auctions and disposal facilities. (a... disposal facility identified in paragraph (a)(2) or (a)(3) of this section. (2) A disposal facility listed...

Trajectory Design for a Single-String Impactor Concept

NASA Technical Reports Server (NTRS)

Dono Perez, Andres; Burton, Roland; Stupl, Jan; Mauro, David

2017-01-01

This paper introduces a trajectory design for a secondary spacecraft concept to augment science return in interplanetary missions. The concept consist of a single-string probe with a kinetic impactor on board that generates an artificial plume to perform in-situ sampling. The trajectory design was applied to a particular case study that samples ejecta particles from the Jovian moon Europa. Results were validated using statistical analysis. Details regarding the navigation, targeting and disposal challenges related to this concept are presented herein.

Nonoxidative free fatty acid disposal is greater in young women than men.

PubMed

Koutsari, Christina; Basu, Rita; Rizza, Robert A; Nair, K Sreekumaran; Khosla, Sundeep; Jensen, Michael D

2011-02-01

Large increases in systemic free fatty acid (FFA) availability in the absence of a corresponding increase in fatty acid oxidation can create a host of metabolic abnormalities. These adverse responses are thought to be the result of fatty acids being shunted into hepatic very low-density lipoprotein-triglyceride production and/or intracellular lipid storage and signaling pathways because tissues are forced to increase nonoxidative FFA disposal. The objective of the study was to examine whether variations in postabsorptive nonoxidative FFA disposal within the usual range predict insulin resistance and hypertriglyceridemia. We measured: systemic FFA turnover using a continuous iv infusion of [9-10, (3)H]palmitate; substrate oxidation with indirect calorimetry combined with urinary nitrogen excretion; whole-body and peripheral insulin sensitivity with the labeled iv glucose tolerance test minimal model. the study was conducted at the Mayo Clinic General Clinical Research Center. Participants included healthy, postabsorptive, nonobese adults (21 women and 21 men). There were no interventions. Nonoxidative FFA disposal (micromoles per minute), defined as the FFA disappearance rate minus fatty acid oxidation. Women had 64% greater nonoxidative FFA disposal rate than men but a better lipid profile and similar insulin sensitivity. There was no significant correlation between nonoxidative FFA disposal and whole-body sensitivity, peripheral insulin sensitivity, or fasting serum triglyceride concentrations in men or women. Healthy nonobese women have greater rates of nonoxidative FFA disposal than men, but this does not appear to relate to adverse health consequences. Understanding the sex-specific interaction between adipose tissue lipolysis and peripheral FFA removal will help to discover new approaches to treat FFA-induced abnormalities.

End-of-life disposal of high elliptical orbit missions: The case of INTEGRAL

NASA Astrophysics Data System (ADS)

Armellin, Roberto; San-Juan, Juan F.; Lara, Martin

2015-08-01

Nowadays there is international consensus that space activities must be managed to minimize debris generation and risk. The paper presents a method for the end-of-life (EoL) disposal of spacecraft in high elliptical orbits (HEO). The time evolution of HEO is strongly affected by Earth's oblateness and luni-solar perturbation, and this can cause in the long-term to extended interferences with low Earth orbit (LEO) protected region and uncontrolled Earth re-entry. An EoL disposal concept that exploits the effect of orbital perturbations to reduce the disposal cost is presented. The problem is formulated as a multiobjective optimization problem, which is solved with an evolutionary algorithm. To explore at the best the search space a semi-analytical orbit propagator, which allows the propagation of the orbit motion for 100 years in few seconds, is adopted. The EoL disposal of the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) mission is used as a practical test-case to show the effectiveness of the proposed methodology.

Preliminary risk assessment for nuclear waste disposal in space, volume 2

NASA Technical Reports Server (NTRS)

Rice, E. E.; Denning, R. S.; Friedlander, A. L.

1982-01-01

Safety guidelines are presented. Waste form, waste processing and payload fabrication facilities, shipping casks and ground transport vehicles, payload primary container/core, radiation shield, reentry systems, launch site facilities, uprooted space shuttle launch vehicle, Earth packing orbits, orbit transfer systems, and space destination are discussed. Disposed concepts and risks are then discussed.

Comparative Analyses of H3K4 and H3K27 Trimethylations Between the Mouse Cerebrum and Testis

PubMed Central

Cui, Peng; Liu, Wanfei; Zhao, Yuhui; Lin, Qiang; Zhang, Daoyong; Ding, Feng; Xin, Chengqi; Zhang, Zhang; Song, Shuhui; Sun, Fanglin; Yu, Jun; Hu, Songnian

2012-01-01

The global features of H3K4 and H3K27 trimethylations (H3K4me3 and H3K27me3) have been well studied in recent years, but most of these studies were performed in mammalian cell lines. In this work, we generated the genome-wide maps of H3K4me3 and H3K27me3 of mouse cerebrum and testis using ChIP-seq and their high-coverage transcriptomes using ribominus RNA-seq with SOLiD technology. We examined the global patterns of H3K4me3 and H3K27me3 in both tissues and found that modifications are closely-associated with tissue-specific expression, function and development. Moreover, we revealed that H3K4me3 and H3K27me3 rarely occur in silent genes, which contradicts the findings in previous studies. Finally, we observed that bivalent domains, with both H3K4me3 and H3K27me3, existed ubiquitously in both tissues and demonstrated an invariable preference for the regulation of developmentally-related genes. However, the bivalent domains tend towards a “winner-takes-all” approach to regulate the expression of associated genes. We also verified the above results in mouse ES cells. As expected, the results in ES cells are consistent with those in cerebrum and testis. In conclusion, we present two very important findings. One is that H3K4me3 and H3K27me3 rarely occur in silent genes. The other is that bivalent domains may adopt a “winner-takes-all” principle to regulate gene expression. PMID:22768982

Analysis of space systems for the space disposal of nuclear waste follow-on study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1982-01-01

The impact on space systems of three alternative waste mixes was evaluated as part of an effort to investigate the disposal of certain high-level nuclear wastes in space as a complement to mined geologic repositories. A brief overview of the study background, objectives, scope, approach and guidelines, and limitations is presented. The effects of variations in waste mixes on space system concepts were studied in order to provide data for determining relative total system risk benefits resulting from space disposal of the alternative waste mixes. Overall objectives of the NASA-DOE sustaining-level study program are to investigate space disposal concepts which can provide information to support future nuclear waste terminal storage programmatic decisions and to maintain a low level of research activity in this area to provide a baseline for future development should a decision be made to increase the emphasis on this option.

U.S. program assessing nuclear waste disposal in space - A status report

NASA Technical Reports Server (NTRS)

Rice, E. E.; Priest, C. C.; Friedlander, A. L.

1980-01-01

Various concepts for the space disposal of nuclear waste are discussed, with attention given to the destinations now being considered (high earth orbit, lunar orbit, lunar surface, solar orbit, solar system escape, sun). Waste mixes are considered in the context of the 'Purex' (Plutonium and Uranium extraction) process and the potential forms for nuclear waste disposal (ORNL cermet, Boro-silicate glass, Metal matrix, Hot-pressed supercalcine) are described. Preliminary estimates of the energy required and the cost surcharge needed to support the space disposal of nuclear waste are presented (8 metric tons/year, requiring three Shuttle launches). When Purex is employed, the generated electrical energy needed to support the Shuttle launches is shown to be less than 1%, and the projected surcharge to electrical users is shown to be slightly more than two mills/kW-hour.

Material dependence of 2H(d,p)3H cross section at the very low energies

NASA Astrophysics Data System (ADS)

Kılıç, Ali İhsan; Czerski, Konrad; Kuştan-Kılıç, Fadime; Targosz-Sleczka, Natalia; Weissbach, Daniel; Huke, Armin; Ruprecht, Götz

2017-09-01

Calculations of the material dependence of 2H(d,p)3H cross section and neutron-to-proton branching ratio of d+d reactions have been performed including a concept of the 0+ threshold single particle resonance. The resonance has been assumed to explain the enhanced electron screening effect observed in the d+d reaction for different metallic targets. Here, we have included interference effects between the flat and resonance part of the cross section, which allowed us to enlighten observed suppression of the neutron channel in some metals such as Sr and Li. Since the position of the resonance depends on the screening energy that strongly depends on the local electron density. The resonance width, observed for the d+d reactions in the very hygroscopic metals (Sr and Li) and therefore probably contaminated by oxides, should be much larger than for other metals. Thus, the interference term of the cross section depending on the total resonance width provides the material dependences.

Are Disposable and Standard Gonioscopy Lenses Comparable?

PubMed

Lee, Bonny; Szirth, Bernard C; Fechtner, Robert D; Khouri, Albert S

2017-04-01

Gonioscopy is important in the evaluation and treatment of glaucoma. With increased scrutiny of acceptable sterilization processes for health care instruments, disposable gonioscopy lenses have recently been introduced. Single-time use lenses are theorized to decrease infection risk and eliminate the issue of wear and tear seen on standard, reusable lenses. However, patient care would be compromised if the quality of images produced by the disposable lens were inferior to those produced by the reusable lens. The purpose of this study was to compare the quality of images produced by disposable versus standard gonioscopy lenses. A disposable single mirror lens (Sensor Medical Technology) and a standard Volk G-1 gonioscopy lens were used to image 21 volunteers who were prospectively recruited for the study. Images of the inferior and temporal angles of each subject's left eye were acquired using a slit-lamp camera through the disposable and standard gonioscopy lens. In total, 74 images were graded using the Spaeth gonioscopic system and for clarity and quality. Clarity was scored as 1 or 2 and defined as either (1) all structures perceived or (2) all structures not perceived. Quality was scored as 1, 2, or 3, and defined as (1) all angle landmarks clear and well focused, (2) some angle landmarks clear, others blurred, or (3) angle landmarks could not be ascertained. The 74 images were divided into images taken with the disposable single mirror lens and images taken with the standard Volk G-1 gonioscopy lens. The clarity and quality scores for each of these 2 image groups were averaged and P-values were calculated. Average quality of images produced with the standard lens was 1.46±0.56 compared with 1.54±0.61 for those produced with the disposable lens (P=0.55). Average clarity of images produced with the standard lens was 1.47±0.51 compared with 1.49±0.51 (P=0.90) with the disposable lens. We conclude that there is no significant difference in quality of images

Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes.

PubMed

Calin, G A; Gafà, R; Tibiletti, M G; Herlea, V; Becheanu, G; Cavazzini, L; Barbanti-Brodano, G; Nenci, I; Negrini, M; Lanza, G

2000-05-20

Colon carcinomas with microsatellite mutator phenotype exhibit specific genetic and clinico-pathological features. This report describes the analysis of 63 "microsatellite instability-high" (MSI-H) tumors for the presence of mutations in microsatellites located in the coding regions (CDRs) of 6 genes: TGFbetaRII, BAX, hMSH3, hMSH6, IGFIIR, and BLM. The following frequencies of mutations were detected: TGFbetaRII (70%), BAX (54%), hMSH3 (36.5%), IGFIIR (22%), hMSH6 (17.5%), and BLM (16%). The overall picture revealed combinations of mutations suggestive of a progressive order of accumulation, with mutations of TGFbetaRII and BAX first, followed by frameshifts in hMSH3, hMSH6, IGFIIR, and BLM. Correlations with 12 clinico-pathological parameters revealed that tumors with frameshifts in 1 or 2 CDRs were significantly better differentiated than tumors with frameshifts in more than 2 CDRs. We also found that mutations in the hMSH3 gene were significantly associated with decreased wall invasiveness and aneuploidy, and frameshifts in the BLM gene were significantly associated with the mucinous histotype. A trend toward an association between hMSH3 and IGFIIR with the medullary and conventional adenocarcinoma histotypes, respectively, was seen. Our results strengthen the concept that mutations in target genes have a role in the tumorigenic process of MSI-H tumors, and indicate that frameshifts in microsatellites located in CDRs occur in a limited number of combinations that could determine distinct clinico-pathological traits. Copyright 2000 Wiley-Liss, Inc.

Comparison of (/sup 3/H)nicotine and (/sup 3/H)acetylcholine binding in mouse brain: regional distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sershen, H.; Reith, M.E.; Hashim, A.

1985-06-01

In a continuing study of nicotine binding sites, the authors determined the relative amount of nicotine binding and acetylcholine binding in various brain regions of C57/BL and of DBA mice. Although midbrain showed the highest and cerebellum the lowest binding for both (/sup 3/H)nicotine and (/sup 3/H)acetylcholine, the ratio of nicotine to acetylcholine binding showed a three-fold regional variation. Acetylcholine inhibition of (/sup 3/H)nicotine binding indicated that a portion of nicotine binding was not inhibited by acetylcholine. These results indicate important differences between the binding of (+/-)-(/sup 3/H)nicotine and that of (/sup 3/H)acetylcholine.

Rapid measurement of 3J(H N-H alpha) and 3J(N-H beta) coupling constants in polypeptides.

PubMed

Barnwal, Ravi Pratap; Rout, Ashok K; Chary, Kandala V R; Atreya, Hanudatta S

2007-12-01

We present two NMR experiments, (3,2)D HNHA and (3,2)D HNHB, for rapid and accurate measurement of 3J(H N-H alpha) and 3J(N-H beta) coupling constants in polypeptides based on the principle of G-matrix Fourier transform NMR spectroscopy and quantitative J-correlation. These experiments, which facilitate fast acquisition of three-dimensional data with high spectral/digital resolution and chemical shift dispersion, will provide renewed opportunities to utilize them for sequence specific resonance assignments, estimation/characterization of secondary structure with/without prior knowledge of resonance assignments, stereospecific assignment of prochiral groups and 3D structure determination, refinement and validation. Taken together, these experiments have a wide range of applications from structural genomics projects to studying structure and folding in polypeptides.

24 CFR 586.45 - Disposal of buildings and property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Disposal of buildings and property... ASSISTANCE-COMMUNITY REDEVELOPMENT AND HOMELESS ASSISTANCE § 586.45 Disposal of buildings and property. (a... from HUD under § 586.35(c)(1) or § 586.35(d)(2), DoD shall dispose of buildings and property in...

Efficacy of carprofen on conception rates in lactating dairy cows after subcutaneous or intrauterine administration at the time of breeding.

PubMed

Heuwieser, W; Iwersen, M; Goetze, L

2011-01-01

Manipulation of the reproductive tract can cause inflammatory processes in the endometrium and release of cytokines and prostaglandins. It has been shown that PGF2α has direct negative effects on embryonic survival and development. Treatment with nonsteroidal antiinflammatory drugs (e.g., ibuprofen lysinate, flunixin meglumine) might improve pregnancy rates after embryo transfer in recipient heifers. The primary objective of this study was to evaluate the effect of a nonsteroidal antiinflammatory drug on reproductive performance in lactating dairy cows when administered at the time of first-service artificial insemination (AI) based on the hypothesis that uterine manipulation during AI might be similarly intense compared with embryo transfer in its effect on prostaglandin release. A total of 970 cows (333 primiparous and 637 multiparous) from 17 Holstein dairy farms were enrolled. On the day of first AI, cows were randomly allocated to 1 of 3 treatment groups. Cows of group 1 received 1.4 mg/kg of body weight (BW) of carprofen subcutaneously immediately after AI (SC group). In group 2, 1.4 mg/kg of BW of carprofen was administered into the uterus using a sterile disposable catheter 12 to 24 h after AI (IU group). Animals of group 3 remained as untreated controls. First AI conception rate was similar for the SC group (42.2%) compared with the untreated control group (45.1%). A binary logistic regression model for the odds of conception at first AI revealed a negative effect of an intrauterine administration of carprofen on conception rate (38.3%). Cows allocated to the IU group had a lower likelihood of being pregnant within 200 d in milk than cows in the control group. In summary, subcutaneous treatment with the nonsteroidal antiinflammatory drug carprofen at the time of AI did not influence conception rate, whereas an intrauterine administration of carprofen 12 to 24 h after first AI had a negative effect on first-service conception rate in lactating dairy cows

Phase Equilibria and Transport Properties in the Systems AgNO3/RCN/H2O. R = CH3, C2H5, C3H7, C4H,, C6H5, and C6H5CH2

NASA Astrophysics Data System (ADS)

Das, Surjya P.; Wittekopf, Burghard; Weil, Konrad G.

1988-11-01

Silver nitrate can form homogeneous liquid phases with some organic nitriles and water, even when there is no miscibility between the pure liquid components. We determined the shapes of the single phase regions in the ternary phase diagram for the following systems: silver nitrate /RCN /H2O with R =CH3, C3H7, C6H5, and C6H5CH2 at room temperature and for R =C6H5 also at 60 °C and O °C. Furthermore we studied kinematic viscosities, electrical conductivities, and densities of mixtures containing silver nitrate, RCN, and water with the mole ratios X /4 /1 (0.2≦ X ≦S 3.4). In these cases also R = C2H5 and C4H9 were studied. The organic nitriles show different dependences of viscosity and conductivity on the silver nitrate content from the aliphatic ones.

Disposal of disused sealed radiation sources in Boreholes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vicente, R.

2007-07-01

This paper gives a description of the concept of a geological repository for disposal of disused sealed radiation sources (DSRS) under development in the Institute of Energy and Nuclear Research (IPEN), in Brazil. DSRS represent a significant fraction of total activity of radioactive wastes to be managed. Most DSRS are collected and temporarily stored at IPEN. As of 2006, the total collected activity is 800 TBq in 7,508 industrial gauge or radiotherapy sources, 7.2 TBq in about 72,000 Americium-241 sources detached from lightning rods, and about 0,5 GBq in 20,857 sources from smoke detectors. The estimated inventory of sealed sourcesmore » in the country is 2.7 hundred thousand sources with 26 PBq. The proposed repository is designed to receive the total inventory of sealed sources. A description of the pre-disposal facilities at IPEN is also presented. (authors)« less

Radical-molecule reaction C3H+H2O: a mechanistic study.

PubMed

Dong, Hao; Ding, Yi-Hong; Sun, Chia-Chung

2005-02-08

Despite the importance of the C(3)H radical in both combustion and interstellar space, the reactions of C(3)H toward stable molecules have never been studied. In this paper, we report our detailed mechanistic study on the radical-molecule reaction C(3)H+H(2)O at the Becke's three parameter Lee-Yang-Parr-B3LYP6-311G(d,p) and coupled cluster with single, double, and triple excitations-CCSD(T)6-311G(2d,p) (single-point) levels. It is shown that the C(3)H+H(2)O reaction initially favors formation of the carbene-insertion intermediates HCCCHOH (1a,1b) rather than the direct H- or OH-abstraction process. Subsequently, the isomers (1a,1b) can undergo a direct H- extrusion to form the well-known product propynal HCCCHO (P(5)). Highly competitively, (1a,1b) can take the successive 1,4- and 1,2-H-shift interconversion to isomer H(2)CCCHO(2a,2b) and then to isomer H(2)CCHCO(3a,3b), which can finally take a direct C-C bond cleavage to give product C(2)H(3) and CO (P(1)). The other products are kinetically much less feasible. With the overall entrance barrier 10.6 kcal/mol, the title reaction can be important in postburning processes. Particularly, our calculations suggest that the title reaction may play a role in the formation of the intriguing interstellar molecule, propynal HCCCHO. The calculated results will also be useful for the analogous C(3)H reactions such as with ammonia and alkanes.

The allocation of valenced concepts onto 3D space.

PubMed

Marmolejo-Ramos, Fernando; Tirado, Carlos; Arshamian, Edward; Vélez, Jorge Iván; Arshamian, Artin

2018-06-01

The valence-space metaphor research area investigates the metaphorical mapping of valenced concepts onto space. Research findings from this area indicate that positive, neutral, and negative concepts are associated with upward, midward, and downward locations, respectively, in the vertical plane. The same research area has also indicated that such concepts seem to have no preferential location on the horizontal plane. The approach-avoidance effect consists in decreasing the distance between positive stimuli and the body (i.e. approach) and increasing the distance between negative stimuli and the body (i.e. avoid). Thus, the valence-space metaphor accounts for the mapping of valenced concepts onto the vertical and horizontal planes, and the approach-avoidance effect accounts for the mapping of valenced concepts onto the "depth" plane. By using a cube conceived for the study of allocation of valenced concepts onto 3D space, we show in three studies that positive concepts are placed in upward locations and near the participants' body, negative concepts are placed in downward locations and far from the participants' body, and neutral concepts are placed in between these concepts in both planes.

Clinical and treatment effects on /sup 3/H-clonidine and /sup 3/H-imipramine binding in elderly depressed patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Georgotas, A.; Schweitzer, J.; McCue, R.E.

1987-06-01

/sup 3/H-clonidine and /sup 3/H-imipramine binding were measured in depressed patients, 55 years and older. There was no significant difference in either /sup 3/H-clonidine or /sup 3/H-imipramine binding between depressed patients and age- and sex-matched controls. There was no significant correlation between /sup 3/H-clonidine or /sup 3/H-imipramine binding and severity of depression before treatment. There was a significant negative correlation between the K/sub D/ of /sup 3/H-imipramine binding sites and Hamilton score over seven weeks of antidepressant treatment. There was no significant difference between receptor data of responders and nonresponders to antidepressant treatment. 19 references, 2 tables.

Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses' Health Study.

PubMed

Healey, Megan A; Hu, Rong; Beck, Andrew H; Collins, Laura C; Schnitt, Stuart J; Tamimi, Rulla M; Hazra, Aditi

2014-10-01

Repressive histone tail modifications have been associated with molecular breast cancer subtypes. We investigated whether histone 3 lysine 9 trimethylation (H3K9me3) and histone 3 lysine 27 trimethylation (H3K27me3) were associated with tumor features and subtypes while adjusting for prospectively collected reproductive and lifestyle breast cancer risk factors. We have tissue microarray data with immunohistochemical marker information on 804 incident cases of invasive breast cancer diagnosed from 1976-2000 in the Nurses' Health Study. Tissue microarray sections were stained for global H3K9me3 and H3K27me3, and scored into four categories. Multivariate odds ratios (OR) and 95 % confidence intervals (CI) were calculated using logistic regression models for tumor features and subtypes, adjusting for breast cancer risk factors. While there were no significant associations between H3K9me3 and tumor features, H3K27me3 was significantly associated with lower grade tumors compared to high grade tumors in the multivariate model (OR = 1.95, 95 % CI 1.35-2.81, p = 0.0004). H3K27me3 was suggestively associated with estrogen receptor-positive (ER+) tumors (OR = 1.47, 95 % CI 0.97-2.23, p = 0.07). In subtype analyses, H3K27me3 was positively associated with the luminal A subtype compared to all other subtypes (OR = 1.42, 95 % CI 1.14-1.77, p = 0.002), and was inversely associated with HER2-type (OR = 0.58, 95 % CI 0.37-0.91, p = 0.02) and basal-like breast cancer (OR = 0.52, 95 % CI 0.36-0.76, p = 0.0006). In the largest immunohistochemical examination of H3K9me3 and H3K27me3 in breast cancer, we found that H3K27me3 positivity, but not H3K9me3, was associated with lower grade tumors and the luminal A subtype after adjusting for reproductive and lifestyle breast cancer risk factors.

Study of extraterrestrial disposal of radioactive wastes. Part 3: Preliminary feasibility screening study of space disposal of the actinide radioactive wastes with 1 percent and 0.1 percent fission product contamination

NASA Technical Reports Server (NTRS)

Hyland, R. E.; Wohl, M. L.; Finnegan, P. M.

1973-01-01

A preliminary study was conducted of the feasibility of space disposal of the actinide class of radioactive waste material. This waste was assumed to contain 1 and 0.1 percent residual fission products, since it may not be feasible to completely separate the actinides. The actinides are a small fraction of the total waste but they remain radioactive much longer than the other wastes and must be isolated from human encounter for tens of thousands of years. Results indicate that space disposal is promising but more study is required, particularly in the area of safety. The minimum cost of space transportation would increase the consumer electric utility bill by the order of 1 percent for earth escape and 3 percent for solar escape. The waste package in this phase of the study was designed for normal operating conditions only; the design of next phase of the study will include provisions for accident safety. The number of shuttle launches per year required to dispose of all U.S. generated actinide waste with 0.1 percent residual fission products varies between 3 and 15 in 1985 and between 25 and 110 by 2000. The lower values assume earth escape (solar orbit) and the higher values are for escape from the solar system.

Performance assessment methodology and preliminary results for low-level radioactive waste disposal in Taiwan.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnold, Bill Walter; Chang, Fu-lin; Mattie, Patrick D.

2006-02-01

Sandia National Laboratories (SNL) and Taiwan's Institute for Nuclear Energy Research (INER) have teamed together to evaluate several candidate sites for Low-Level Radioactive Waste (LLW) disposal in Taiwan. Taiwan currently has three nuclear power plants, with another under construction. Taiwan also has a research reactor, as well as medical and industrial wastes to contend with. Eventually the reactors will be decomissioned. Operational and decommissioning wastes will need to be disposed in a licensed disposal facility starting in 2014. Taiwan has adopted regulations similar to the US Nuclear Regulatory Commission's (NRC's) low-level radioactive waste rules (10 CFR 61) to govern themore » disposal of LLW. Taiwan has proposed several potential sites for the final disposal of LLW that is now in temporary storage on Lanyu Island and on-site at operating nuclear power plants, and for waste generated in the future through 2045. The planned final disposal facility will have a capacity of approximately 966,000 55-gallon drums. Taiwan is in the process of evaluating the best candidate site to pursue for licensing. Among these proposed sites there are basically two disposal concepts: shallow land burial and cavern disposal. A representative potential site for shallow land burial is located on a small island in the Taiwan Strait with basalt bedrock and interbedded sedimentary rocks. An engineered cover system would be constructed to limit infiltration for shallow land burial. A representative potential site for cavern disposal is located along the southeastern coast of Taiwan in a tunnel system that would be about 500 to 800 m below the surface. Bedrock at this site consists of argillite and meta-sedimentary rocks. Performance assessment analyses will be performed to evaluate future performance of the facility and the potential dose/risk to exposed populations. Preliminary performance assessment analyses will be used in the site-selection process and to aid in design of

Analysis of nuclear waste disposal in space, phase 3. Volume 1: Executive summary of technical report

NASA Technical Reports Server (NTRS)

Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

1980-01-01

The objectives, approach, assumptions, and limitations of a study of nuclear waste disposal in space are discussed with emphasis on the following: (1) payload characterization; (2) safety assessment; (3) health effects assessment; (4) long-term risk assessment; and (5) program planning support to NASA and DOE. Conclusions are presented for each task.

49 CFR 599.201 - Identification of salvage auctions and disposal facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... on the Web site at http://www.cars.gov/disposal; or (3) A facility that disposes of vehicles in...) of this section, be currently listed on the Web site at http://www.cars.gov/disposal, as of the date.... (1) A disposal facility that qualifies as such by active membership in ELVS and that fails to...

49 CFR 599.201 - Identification of salvage auctions and disposal facilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... on the Web site at http://www.cars.gov/disposal; or (3) A facility that disposes of vehicles in...) of this section, be currently listed on the Web site at http://www.cars.gov/disposal, as of the date.... (1) A disposal facility that qualifies as such by active membership in ELVS and that fails to...

49 CFR 599.201 - Identification of salvage auctions and disposal facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... on the Web site at http://www.cars.gov/disposal; or (3) A facility that disposes of vehicles in...) of this section, be currently listed on the Web site at http://www.cars.gov/disposal, as of the date.... (1) A disposal facility that qualifies as such by active membership in ELVS and that fails to...

49 CFR 599.201 - Identification of salvage auctions and disposal facilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... on the Web site at http://www.cars.gov/disposal; or (3) A facility that disposes of vehicles in...) of this section, be currently listed on the Web site at http://www.cars.gov/disposal, as of the date.... (1) A disposal facility that qualifies as such by active membership in ELVS and that fails to...

A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.

PubMed

Ott, Heidi M; Graves, Alan P; Pappalardi, Melissa B; Huddleston, Michael; Halsey, Wendy S; Hughes, Ashley M; Groy, Arthur; Dul, Edward; Jiang, Yong; Bai, Yuchen; Annan, Roland; Verma, Sharad K; Knight, Steven D; Kruger, Ryan G; Dhanak, Dashyant; Schwartz, Benjamin; Tummino, Peter J; Creasy, Caretha L; McCabe, Michael T

2014-12-01

The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27). Recently, EZH2 mutations have been reported at Y641, A677, and A687 in non-Hodgkin lymphoma. Although the Y641F/N/S/H/C and A677G mutations exhibit clearly increased activity with substrates dimethylated at lysine 27 (H3K27me2), the A687V mutant has been shown to prefer a monomethylated lysine 27 (H3K27me1) with little gain of activity toward H3K27me2. Herein, we demonstrate that despite this unique substrate preference, A687V EZH2 still drives increased H3K27me3 when transiently expressed in cells. However, unlike the previously described mutants that dramatically deplete global H3K27me2 levels, A687V EZH2 retains normal levels of H3K27me2. Sequencing of B-cell-derived cancer cell lines identified an acute lymphoblastic leukemia cell line harboring this mutation. Similar to exogenous expression of A687V EZH2, this cell line exhibited elevated H3K27me3 while possessing H3K27me2 levels higher than Y641- or A677-mutant lines. Treatment of A687V EZH2-mutant cells with GSK126, a selective EZH2 inhibitor, was associated with a global decrease in H3K27me3, robust gene activation, caspase activation, and decreased proliferation. Structural modeling of the A687V EZH2 active site suggests that the increased catalytic activity with H3K27me1 may be due to a weakened interaction with an active site water molecule that must be displaced for dimethylation to occur. These findings suggest that A687V EZH2 likely increases global H3K27me3 indirectly through increased catalytic activity with H3K27me1 and cells harboring this mutation are highly dependent on EZH2 activity for their survival. ©2014 American Association for Cancer Research.

48 CFR 204.805 - Disposal of contract files.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files. (1...

48 CFR 204.805 - Disposal of contract files.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files. (1...

48 CFR 204.805 - Disposal of contract files.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files. (1...

48 CFR 204.805 - Disposal of contract files.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files. (1...

48 CFR 204.805 - Disposal of contract files.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files. (1...

Conceptual waste packaging options for deep borehole disposal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Jiann -Cherng; Hardin, Ernest L.

This report presents four concepts for packaging of radioactive waste for disposal in deep boreholes. Two of these are reference-size packages (11 inch outer diameter) and two are smaller (5 inch) for disposal of Cs/Sr capsules. All four have an assumed length of approximately 18.5 feet, which allows the internal length of the waste volume to be 16.4 feet. However, package length and volume can be scaled by changing the length of the middle, tubular section. The materials proposed for use are low-alloy steels, commonly used in the oil-and-gas industry. Threaded connections between packages, and internal threads used to sealmore » the waste cavity, are common oilfield types. Two types of fill ports are proposed: flask-type and internal-flush. All four package design concepts would withstand hydrostatic pressure of 9,600 psi, with factor safety 2.0. The combined loading condition includes axial tension and compression from the weight of a string or stack of packages in the disposal borehole, either during lower and emplacement of a string, or after stacking of multiple packages emplaced singly. Combined loading also includes bending that may occur during emplacement, particularly for a string of packages threaded together. Flask-type packages would be fabricated and heat-treated, if necessary, before loading waste. The fill port would be narrower than the waste cavity inner diameter, so the flask type is suitable for directly loading bulk granular waste, or loading slim waste canisters (e.g., containing Cs/Sr capsules) that fit through the port. The fill port would be sealed with a tapered, threaded plug, with a welded cover plate (welded after loading). Threaded connections between packages and between packages and a drill string, would be standard drill pipe threads. The internal flush packaging concepts would use semi-flush oilfield tubing, which is internally flush but has a slight external upset at the joints. This type of tubing can be obtained with premium

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

NASA Technical Reports Server (NTRS)

Chullen, Cinda

2010-01-01

With the retirement of the Space Shuttle fleet imminent in 2011, a new concept of operations will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), the Japan Aerospace Exploration Agency's (JAXA's) H-II Transfer Vehicle (HTV) and the Boeing Delta IV Heavy (DIV-H). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

Preliminary Comparison of Radioactive Waste Disposal Cost for Fusion and Fission Reactors

NASA Astrophysics Data System (ADS)

Seki, Yasushi; Aoki, Isao; Yamano, Naoki; Tabara, Takashi

1997-09-01

The environmental and economic impact of radioactive waste (radwaste) generated from fusion power reactors using five types of structural materials and a fission reactor has been evaluated and compared. Possible radwaste disposal scenario of fusion radwaste in Japan is considered. The exposure doses were evaluated for the skyshine of gamma-ray during the disposal operation, groundwater migration scenario during the institutional control period of 300 years and future site use scenario after the institutional period. The radwaste generated from a typical light water fission reactor was evaluated using the same methodology as for the fusion reactors. It is found that radwaste from the fusion reactors using F82H and SiC/SiC composites without impurities could be disposed by the shallow land disposal presently applied to the low level waste in Japan. The disposal cost of radwaste from five fusion power reactors and a typical light water reactor were roughly evaluated and compared.

A simple hydrogen-bonded chain in (3Z)-3-{1-[(5-phenyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one, and a hydrogen-bonded ribbon of centrosymmetric rings in the self-assembled adduct (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one-6-(2-hydroxyethyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one (1/1).

PubMed

Quiroga, Jairo; Portilla, Jaime; Cobo, Justo; Glidewell, Christopher

2010-01-01

(3Z)-3-{1-[(5-Phenyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one, C(15)H(15)N(3)O(2), (I), and the stoichiometric adduct (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one-6-(2-hydroxyethyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one (1/1), C(10)H(13)N(3)O(2).C(10)H(13)N(3)O(2), (II), in which the two components have the same composition but different constitutions, are formed in the reactions of 2-acetyl-4-butyrolactone with 5-amino-3-phenyl-1H-pyrazole and 5-amino-3-methyl-1H-pyrazole, respectively. In each compound, the furanone component contains an intramolecular N-H...O hydrogen bond. The molecules of (I) are linked into a chain by a single intermolecular N-H...O hydrogen bond, while in (II), a combination of one O-H...N hydrogen bond, within the selected asymmetric unit, and two N-H...O hydrogen bonds link the molecular components into a ribbon containing alternating centrosymmetric R(4)(4)(20) and R(6)(6)(22) rings.

TEXSYS. [a knowledge based system for the Space Station Freedom thermal control system test-bed

NASA Technical Reports Server (NTRS)

Bull, John

1990-01-01

The Systems Autonomy Demonstration Project has recently completed a major test and evaluation of TEXSYS, a knowledge-based system (KBS) which demonstrates real-time control and FDIR for the Space Station Freedom thermal control system test-bed. TEXSYS is the largest KBS ever developed by NASA and offers a unique opportunity for the study of technical issues associated with the use of advanced KBS concepts including: model-based reasoning and diagnosis, quantitative and qualitative reasoning, integrated use of model-based and rule-based representations, temporal reasoning, and scale-up performance issues. TEXSYS represents a major achievement in advanced automation that has the potential to significantly influence Space Station Freedom's design for the thermal control system. An overview of the Systems Autonomy Demonstration Project, the thermal control system test-bed, the TEXSYS architecture, preliminary test results, and thermal domain expert feedback are presented.

Interconversion of η3-H2SiRR' σ-complexes and 16-electron silylene complexes via reversible H-H or C-H elimination.

PubMed

Lipke, Mark C; Neumeyer, Felix; Tilley, T Don

2014-04-23

Solid samples of η(3)-silane complexes [PhBP(Ph)3]RuH(η(3)-H2SiRR') (R,R' = Et2, 1a; PhMe, 1b; Ph2, 1c, MeMes, 1d) decompose when exposed to dynamic vacuum. Gas-phase H2/D2 exchange between isolated, solid samples of 1c-d3 and 1c indicate that a reversible elimination of H2 is the first step in the irreversible decomposition. An efficient solution-phase trap for hydrogen, the 16-electron ruthenium benzyl complex [PhBP(Ph)3]Ru[η(3)-CH2(3,5-Me2C6H3)] (3) reacts quantitatively with H2 in benzene via elimination of mesitylene to form the η(5)-cyclohexadienyl complex [PhBP(Ph)3]Ru(η(5)-C6H7) (4). This H2 trapping reaction was utilized to drive forward and quantify the elimination of H2 from 1b,d in solution, which resulted in the decomposition of 1b,d to form 4 and several organosilicon products that could not be identified. Reaction of {[PhBP(Ph)3]Ru(μ-Cl)}2 (2) with (THF)2Li(SiHMes2) forms a new η(3)-H2Si species [PhBP(Ph)3]Ru[CH2(2-(η(3)-H2SiMes)-3,5-Me2C6H2)] (5) which reacts with H2 to form the η(3)-H2SiMes2 complex [PhBP(Ph)3]RuH(η(3)-H2SiMes2) (1e). Complex 1e was identified by NMR spectroscopy prior to its decomposition by elimination of Mes2SiH2 to form 4. DFT calculations indicate that an isomer of 5, the 16-electron silylene complex [PhBP(Ph)3]Ru(μ-H)(═SiMes2), is only 2 kcal/mol higher in energy than 5. Treatment of 5 with XylNC (Xyl = 2,6-dimethylphenyl) resulted in trapping of [PhBP(Ph)3]Ru(μ-H)(═SiMes2) to form the 18-electron silylene complex [PhBP(Ph)3]Ru(CNXyl)(μ-H)(═SiMes2) (6). A closely related germylene complex [PhBP(Ph)3]Ru[CN(2,6-diphenyl-4-MeC6H2)](H)(═GeH(t)Bu) (8) was prepared from reaction of (t)BuGeH3 with the benzyl complex [PhBP(Ph)3]Ru[CN(2,6-diphenyl-4-MeC6H2)][η(1)-CH2(3,5-Me2C6H3)] (7). Single crystal XRD analysis indicated that unlike for 6, the hydride ligand in 8 is a terminal hydride that does not engage in 3c-2e Ru-H → Ge bonding. Complex 1b is an effective precatalyst for the catalytic Ge-H dehydrocoupling

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

PubMed

Earnshaw, W C; Allshire, R C; Black, B E; Bloom, K; Brinkley, B R; Brown, W; Cheeseman, I M; Choo, K H A; Copenhaver, G P; Deluca, J G; Desai, A; Diekmann, S; Erhardt, S; Fitzgerald-Hayes, M; Foltz, D; Fukagawa, T; Gassmann, R; Gerlich, D W; Glover, D M; Gorbsky, G J; Harrison, S C; Heun, P; Hirota, T; Jansen, L E T; Karpen, G; Kops, G J P L; Lampson, M A; Lens, S M; Losada, A; Luger, K; Maiato, H; Maddox, P S; Margolis, R L; Masumoto, H; McAinsh, A D; Mellone, B G; Meraldi, P; Musacchio, A; Oegema, K; O'Neill, R J; Salmon, E D; Scott, K C; Straight, A F; Stukenberg, P T; Sullivan, B A; Sullivan, K F; Sunkel, C E; Swedlow, J R; Walczak, C E; Warburton, P E; Westermann, S; Willard, H F; Wordeman, L; Yanagida, M; Yen, T J; Yoda, K; Cleveland, D W

2013-04-01

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.

PubMed

Yang, Xiyue; Wang, Jing; Zhou, Zewei; Jiang, Rong; Huang, Jie; Chen, Lulu; Cao, Zhouli; Chu, Han; Han, Bing; Cheng, Yusi; Chao, Jie

2018-06-01

Phagocytosis of silicon dioxide (SiO 2 ) into lung cells causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular RNAs (circRNAs) are a subclass of noncoding RNAs that are present within mammalian cells; however, researchers have not determined whether circRNAs are involved in the pathophysiologic process of silicosis. To elucidate the role of these RNAs in SiO 2 -induced inflammation in pulmonary macrophages, we investigated the upstream molecular mechanisms and functional effects of circRNAs on cell apoptosis, proliferation, and migration. Primary cultures of alveolar macrophages from healthy donors and from patients and the RAW264.7 macrophage cell line were used to explore the functions of circZC3H4 RNA in macrophage activation. The experimental results indicated the following: 1) SiO 2 concomitantly increased circZC3H4 RNA expression and increased ZC3H4 protein levels; 2) circular ZC3H4 (circZC3H4) RNA and ZC3H4 protein participated in SiO 2 -induced macrophage activation; and 3) SiO 2 -activated macrophages promoted fibroblast proliferation and migration via the circZC3H4 RNA/ZC3H4 pathway. The up-regulation of the ZC3H4 protein was confirmed in tissue samples from patients with silicosis. Our study elucidates a link between SiO 2 -induced macrophage activation and the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potential use of ZC3H4 to develop novel therapeutic strategies for silicosis.-Yang, X., Wang, J., Zhou, Z., Jiang, R., Huang, J., Chen, L., Cao, Z., Chu, H., Han, B., Cheng, Y., Chao, J. Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.

Structurally characterized 1,1,3,3-tetramethylguanidine solvated magnesium aryloxide complexes: [Mg(mu-OEt)(DBP)(H-TMG)]2, [Mg(mu-OBc)(DBP)(H-TMG)]2, [Mg(mu-TMBA)(DBP)(H-TMG)]2, [Mg(mu-DPP)(DBP)(H-TMG)]2, [Mg(BMP)2(H-TMG)2], [Mg(O-2,6-Ph2C6H3)2 (H-TMG)2].

PubMed

Monegan, Jessie D; Bunge, Scott D

2009-04-06

The synthesis and structural characterization of several 1,1,3,3-tetramethylguanidine (H-TMG) solvated magnesium aryloxide complexes are reported. Bu(2)Mg was successfully reacted with H-TMG, HOC(6)H(3)(CMe(3))(2)-2,6 (H-DBP), and either ethanol, a carboxylic acid, or diphenyl phosphate in a 1:1 ratio to yield the corresponding [Mg(mu-L)(DBP)(H-TMG)](2) where L = OCH(2)CH(3) (OEt, 1), O(2)CC(CH(3))(3) (OBc, 2), O(2)C(C(6)H(2)-2,4,6-(CH(3))(3)) (TMBA, 3), or O(2)P(OC(6)H(5))(2) (DPP, 4). Bu(2)Mg was also reacted with two equivalents of H-TMG and HOC(6)H(3)(CMe(3))-2-(CH(3))-6 (BMP) or HO-2,6-Ph(2)C(6)H(3) to yield [Mg(BMP)(2)(H-TMG)(2)] (5) and [Mg(O-2,6-Ph(2)C(6)H(3))(2)(H-TMG)(2)] (6). Compounds 1-6 were characterized by single-crystal X-ray diffraction. Polymerization of l- and rac-lactide with 1 was found to generate polylactide (PLA). A discussion concerning the relevance of compounds 2 - 4 to the structure of Mg-activated phosphatase enzymes is also provided. The bulk powders for all complexes were found to be in agreement with the crystal structures based on elemental analyses, FT-IR spectroscopy, and (1)H, (13)C and (31)P NMR studies.

Draft Geologic Disposal Requirements Basis for STAD Specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilgen, Anastasia G.; Bryan, Charles R.; Hardin, Ernest

2015-03-25

This document provides the basis for requirements in the current version of Performance Specification for Standardized Transportation, Aging, and Disposal Canister Systems, (FCRD-NFST-2014-0000579) that are driven by storage and geologic disposal considerations. Performance requirements for the Standardized Transportation, Aging, and Disposal (STAD) canister are given in Section 3.1 of that report. Here, the requirements are reviewed and the rationale for each provided. Note that, while FCRD-NFST-2014-0000579 provides performance specifications for other components of the STAD storage system (e.g. storage overpack, transfer and transportation casks, and others), these have no impact on the canister performance during disposal, and are not discussedmore » here.« less

Electrical conductivity of aluminum hydride AlH3 at high pressure and temperature

NASA Astrophysics Data System (ADS)

Shakhray, Denis; Molodets, Alexander; Fortov, Vladimir; Khrapak, Aleksei

2009-06-01

A study of electrophysical and thermodynamic properties of alane AlH3 under multi shock compression has been carried out. The increase in specific electroconductivity of alane at shock compression up to pressure 100 GPa have been measured. High pressures and temperatures were obtained with explosive device, which accelerates the stainless impactor up to 3 km/sec. The impact shock is split into a shock wave reverberating in alane between two stiff metal anvils. The conductivity of shocked alane increases in the range up to 60-75 GPa and is about 30 1/Ohm*cm. In this region the semiconductor regime is true for shocked alane. The conductivity of alane achieves approximately 500 1/Ohm*cm at 80-90 GPa. In this region conductivity is interpreted in frames of the conception of the ``dielectric catastrophe'', taking into consideration significant difference between electronic states of isolated AlH3 molecule and condensed alane.

Ocean Disposal Site Monitoring

EPA Pesticide Factsheets

EPA is responsible for managing all designated ocean disposal sites. Surveys are conducted to identify appropriate locations for ocean disposal sites and to monitor the impacts of regulated dumping at the disposal sites.

Review of Propulsion Technologies for N+3 Subsonic Vehicle Concepts

NASA Technical Reports Server (NTRS)

Ashcraft, Scott W.; Padron, Andres S.; Pascioni, Kyle A.; Stout, Gary W., Jr.; Huff, Dennis L.

2011-01-01

NASA has set aggressive fuel burn, noise, and emission reduction goals for a new generation (N+3) of aircraft targeting concepts that could be viable in the 2035 timeframe. Several N+3 concepts have been formulated, where the term "N+3" indicate aircraft three generations later than current state-of-the-art aircraft, "N". Dramatic improvements need to be made in the airframe, propulsion systems, mission design, and the air transportation system in order to meet these N+3 goals. The propulsion system is a key element to achieving these goals due to its major role with reducing emissions, fuel burn, and noise. This report provides an in-depth description and assessment of propulsion systems and technologies considered in the N+3 subsonic vehicle concepts. Recommendations for technologies that merit further research and development are presented based upon their impact on the N+3 goals and likelihood of being operational by 2035.

Humboldt Open Ocean Disposal Site (HOODS) Survey Work 2014

EPA Pesticide Factsheets

The Humboldt Open Ocean Disposal Site (HOODS) is a dredged material disposal site located 3 nautical miles (nm) offshore of Humboldt Bay in Northern California. HOODS was permanently designated by EPA Region 9 in 1995, and has been actively used for dredged material disposal operations since then. The HOODS has received higher volumes of dredged material than predicted since its designation in 1995, mainly from USACE construction and maintenance dredging.

Histone H3 Variants in Trichomonas vaginalis

PubMed Central

Zubáčová, Zuzana; Hostomská, Jitka

2012-01-01

The parabasalid protist Trichomonas vaginalis is a widespread parasite that affects humans, frequently causing vaginitis in infected women. Trichomonad mitosis is marked by the persistence of the nuclear membrane and the presence of an asymmetric extranuclear spindle with no obvious direct connection to the chromosomes. No centromeric markers have been described in T. vaginalis, which has prevented a detailed analysis of mitotic events in this organism. In other eukaryotes, nucleosomes of centromeric chromatin contain the histone H3 variant CenH3. The principal aim of this work was to identify a CenH3 homolog in T. vaginalis. We performed a screen of the T. vaginalis genome to retrieve sequences of canonical and variant H3 histones. Three variant histone H3 proteins were identified, and the subcellular localization of their epitope-tagged variants was determined. The localization of the variant TVAG_185390 could not be distinguished from that of the canonical H3 histone. The sequence of the variant TVAG_087830 closely resembled that of histone H3. The tagged protein colocalized with sites of active transcription, indicating that the variant TVAG_087830 represented H3.3 in T. vaginalis. The third H3 variant (TVAG_224460) was localized to 6 or 12 distinct spots at the periphery of the nucleus, corresponding to the number of chromosomes in G1 phase and G2 phase, respectively. We propose that this variant represents the centromeric marker CenH3 and thus can be employed as a tool to study mitosis in T. vaginalis. Furthermore, we suggest that the peripheral distribution of CenH3 within the nucleus results from the association of centromeres with the nuclear envelope throughout the cell cycle. PMID:22408228

25 CFR 15.3 - Who can make a will disposing of trust or restricted land or trust personalty?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Who can make a will disposing of trust or restricted land or trust personalty? 15.3 Section 15.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROBATE PROBATE OF INDIAN ESTATES, EXCEPT FOR MEMBERS OF THE OSAGE NATION AND THE FIVE CIVILIZED TRIBES Introduction § 15.3 Who can make a will...

Characteristics of leachate in Foot and Mouth Disease Carcass Disposal using Molecular Biology Method

NASA Astrophysics Data System (ADS)

Choi, E. J.; Kim, B. J.; Wi, D. W.; Choi, N. C.; Lee, S. J.; Min, J. E.; Park, C. Y.

2012-04-01

The Leachate from Foot and Mouth Disease(FMD) carcass disposal by is one of the types of high-concentration contaminated wastewater with the greatest environmental impact. This is due to its pollutants: nitrate nitrogen (NO3--N) and pathogenic microorganisms. Satisfactory treatment of leachate is not an easy task for its high concentrations of nitrate nitrogen and pathogenic microorganisms. Therefore suitable FMD leachate treatment processes should be adopted to improve treatment performance and to reduce overall running costs. The objective of this study was to determine the leachate characteristics through environmental analysis and molecular biology method (bacteria identification and Polymerase Chain Reaction) using FMD leachate samples for optimal FMD leachate treatment processes. The Sixteen FMD leachate samples was obtained from carcass disposal regions in Korea. Results of environmental analysis showed that pH and Eh was observed from 5.57 to 7.40, -134~358mV. This data was exhibited typical early carcass disposal (Neutral pH and Reducing Environment by abundant organic matter). TOC and nitrate nitrogen high concentrations in FMD leachate showed a large variability from 2.3 to 38,730 mg/L(mean - 6,821.93mg/L) and 0.335 ~231.998mg/L(mean - 37.46mg/L), respectively. The result of bacteria identification was observed Bacillus cereus, Pseudomonas putida, Acinetobacter ursingii, Aeromonas hydrophila, Serratia liquefaciens, Brevundimonas naejangsanensis, Serratia liquefaciens, Pseudomonas fluorescens, Pseudomonas aeruginosa, Acinetobacter ursingii. The results of Polymerase Chain Reaction(PCR) using EzTaxon server data revealed Pseudoclavibacter helvolus, Pseudochrobactrum saccharolyticum, Corynebacterium callunae, Paenibacillus lautus, Paenibacillus sp., Bacillus arvi, Brevundimonas bullata, Acinetobacter ursingii, Lysinibacillus sphaericus, Bacillus pumilus, Bacillus sphaericus, Bacillus psychrodurans, Pseudomonas sp.

Frequency Comb Assisted IR Measurements of H_3^+, H_2D^+ and D_2H^+ Transitions

NASA Astrophysics Data System (ADS)

Jusko, Pavol; Asvany, Oskar; Schlemmer, Stephan

2016-06-01

We present recent measurements of the fundamental transitions of H_3^+, H_2D^+ and D_2H^+ in a 4 K 22-pole trap by action spectroscopic techniques. Either Laser Induced Inhibition of Cluster Growth (He attachment at T≈4 K), endothermic reaction of H_3^+ with O_2, or deuterium exchange has been used as measurement scheme. We used a 3 μm optical parametric oscillator coupled to a frequency comb in order to achieve accuracy generally below 1 MHz. Five transitions of H_3^+, eleven of H_2D^+ and ten of D_2H^+ were recorder in our spectral range. We compare our H_3^+ results with two previous frequency comb assisted works. Moreover, accurate determination of the frequency allows us to predict pure rotational transitions for H_2D^+ and D_2H^+ in the THz range. P. Jusko, C. Konietzko, S. Schlemmer, O. Asvany, J. Mol. Spec. 319 (2016) 55 O. Asvany, S. Brünken, L. Kluge, S. Schlemmer, Appl. Phys. B 114 (2014) 203 O. Asvany, J. Krieg, S. Schlemmer, Rev. Sci. Instr. 83 (2012) 093110 J.N. Hodges, A.J. Perry, P.A. Jenkins, B.M. Siller, B.J. McCall, J. Chem. Phys. 139 (2013) 164201 H.-C. Chen, C.-Y. Hsiao, J.-L. Peng, T. Amano, J.-T. Shy, Phys. Rev. Lett. 109 (2012) 263002

40 CFR 721.85 - Disposal.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., State, or local laws and regulations. (1) Incineration. (2) Landfill. (3) Deep well injection. (d... by the following. This provision does not supercede any applicable Federal, State, or local laws and regulations. (1) Incineration. (2) Landfill. (3) Deep well injection. (b) Disposal of the process stream...

SLEUTH (Strategies and Lessons to Eliminate Unused Toxicants: Help!). Educational Activities on the Disposal of Household Hazardous Waste. Household Hazardous Waste Disposal Project. Metro Toxicant Program Report No. 1D.

ERIC Educational Resources Information Center

Dyckman, Claire; And Others

This teaching unit is part of the final report of the Household Hazardous Waste Disposal Project. It consists of activities presented in an introduction and three sections. The introduction contains an activity for students in grades 4-12 which defines terms and concepts for understanding household hazardous wastes. Section I provides activities…

12 CFR 222.83 - Disposal of consumer information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Duties of Users of Consumer Reports Regarding Identity Theft § 222.83 Disposal of consumer information. (a) Definitions as used in this section. (1) You means... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Disposal of consumer information. 222.83...

Communication: State-to-state dynamics of the Cl + H2O → HCl + OH reaction: Energy flow into reaction coordinate and transition-state control of product energy disposal.

PubMed

Zhao, Bin; Sun, Zhigang; Guo, Hua

2015-06-28

Quantum state-to-state dynamics of a prototypical four-atom reaction, namely, Cl + H2O → HCl + OH, is investigated for the first time in full dimensionality using a transition-state wave packet method. The state-to-state reactivity and its dependence on the reactant internal excitations are analyzed and found to share many similarities both energetically and dynamically with the H + H2O → H2 + OH reaction. The strong enhancement of reactivity by the H2O stretching vibrational excitations in both reactions is attributed to the favorable energy flow into the reaction coordinate near the transition state. On the other hand, the insensitivity of the product state distributions with regard to reactant internal excitation stems apparently from the transition-state control of product energy disposal.

Identification and Characterization of Switchgrass Histone H3 and CENH3 Genes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miao, Jiamin; Frazier, Taylor; Huang, Linkai

Switchgrass is one of the most promising energy crops and only recently has been employed for biofuel production. The draft genome of switchgrass was recently released; however, relatively few switchgrass genes have been functionally characterized. CENH3, the major histone protein found in centromeres, along with canonical H3 and other histones, plays an important role in maintaining genome stability and integrity. Despite their importance, the histone H3 genes of switchgrass have remained largely uninvestigated. In this study, we identified 17 putative switchgrass histone H3 genes in silico. Of these genes, 15 showed strong homology to histone H3 genes including six H3.1more » genes, three H3.3 genes, four H3.3-like genes and two H3.1-like genes. The remaining two genes were found to be homologous to CENH3. RNA-seq data derived from lowland cultivar Alamo and upland cultivar Dacotah allowed us to identify SNPs in the histone H3 genes and compare their differential gene expression. Interestingly, we also found that overexpression of switchgrass histone H3 and CENH3 genes in N. benthamiana could trigger cell death of the transformed plant cells. Localization and deletion analyses of the histone H3 and CENH3 genes revealed that nuclear localization of the N-terminal tail is essential and sufficient for triggering the cell death phenotype. Lastly, our results deliver insight into the mechanisms underlying the histone-triggered cell death phenotype and provide a foundation for further studying the variations of the histone H3 and CENH3 genes in switchgrass.« less

Identification and Characterization of Switchgrass Histone H3 and CENH3 Genes

DOE PAGES

Miao, Jiamin; Frazier, Taylor; Huang, Linkai; ...

2016-07-12

Switchgrass is one of the most promising energy crops and only recently has been employed for biofuel production. The draft genome of switchgrass was recently released; however, relatively few switchgrass genes have been functionally characterized. CENH3, the major histone protein found in centromeres, along with canonical H3 and other histones, plays an important role in maintaining genome stability and integrity. Despite their importance, the histone H3 genes of switchgrass have remained largely uninvestigated. In this study, we identified 17 putative switchgrass histone H3 genes in silico. Of these genes, 15 showed strong homology to histone H3 genes including six H3.1more » genes, three H3.3 genes, four H3.3-like genes and two H3.1-like genes. The remaining two genes were found to be homologous to CENH3. RNA-seq data derived from lowland cultivar Alamo and upland cultivar Dacotah allowed us to identify SNPs in the histone H3 genes and compare their differential gene expression. Interestingly, we also found that overexpression of switchgrass histone H3 and CENH3 genes in N. benthamiana could trigger cell death of the transformed plant cells. Localization and deletion analyses of the histone H3 and CENH3 genes revealed that nuclear localization of the N-terminal tail is essential and sufficient for triggering the cell death phenotype. Lastly, our results deliver insight into the mechanisms underlying the histone-triggered cell death phenotype and provide a foundation for further studying the variations of the histone H3 and CENH3 genes in switchgrass.« less

Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes.

PubMed

Ortiz, José G; Rassi, Nicole; Maldonado, Patricia M; González-Cabrera, Silvia; Ramos, Igmeris

2006-09-01

Valeriana officinalis extracts are used in folkloric medicine for their sedative, hypnotic and tranquilizer effects. Using [3H]flunitrazepam binding as an indicator, the interactions of commercial Valerian extracts with GABA(A) receptors were examined. There was considerable fluctuation among the different extracts, some mildly enhanced [3H]flunitrazepam binding, others had no effect and others had inhibitory effects, independent of standardization by valerenic acid. Central depression can also be accomplished by a reduction of excitatory transmission. Valerian extracts had modest inhibitory effects on [3H]MK-801 binding, an indicator of NMDA-Valerian interactions. Spectral analyses (UV region) did not show marked differences among the different extracts. The inhibitory effects of one of the extracts on [3H]flunitrazepam binding was somewhat stable, while on [3H]MK-801 binding the inhibitory effects were lost within months. These results suggest that particular care should be taken in analysing and interpreting results from commercial Valerian preparations. Copyright (c) 2006 John Wiley & Sons, Ltd.

Identification of two H3-histamine receptor subtypes

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, R.E. Jr.; Zweig, A.; Shih, N.Y.

The H3-histamine receptor provides feedback inhibition of histamine synthesis and release as well as inhibition of other neurotransmitter release. We have characterized this receptor by radioligand binding studies with the H3 agonist N alpha-(3H)methylhistamine ((3H)NAMHA). The results of (3H)NAMHA saturation binding and NAMHA inhibition of (3H)NAMHA binding were consistent with an apparently single class of receptors (KD = 0.37 nM, Bmax = 73 fmol/mg of protein) and competition assays with other agonists and the antagonists impromidine and dimaprit disclosed only a single class of sites. In contrast, inhibition of (3H)NAMHA binding by the specific high affinity H3 antagonist thioperamide revealedmore » two classes of sites (KiA = 5 nM, BmaxA = 30 fmol/mg of protein; KiB = 68 nM, BmaxB = 48 fmol/mg of protein). Burimamide, another antagonist that, like thioperamide, contains a thiourea group, likewise discriminated between two classes of sites. In addition to differences between some antagonist potencies for the two receptors, there is a differential guanine nucleotide sensitivity of the two. The affinity of the H3A receptor for (3H) NAMHA was reduced less than 2-fold, whereas (3H)NAMHA binding to the H3B receptor was undetectable in the presence of guanosine 5'-O-(3-thiotriphosphate). The distinction between H3A and H3B receptor subtypes, the former a high affinity and the latter a low affinity thioperamide site, draws support from published in vitro data.« less

Artificial Intelligence, Expert Systems, Natural Language Interfaces, Knowledge Engineering and the Librarian.

ERIC Educational Resources Information Center

Davies, Jim

This paper begins by examining concepts of artificial intelligence (AI) and discusses various definitions of the concept that have been suggested in the literature. The nesting relationship of expert systems within the broader framework of AI is described, and expert systems are characterized as knowledge-based systems (KBS) which attempt to solve…

R-matrix description of particle energy spectra produced by low-energy 3H + 3H reactions

DOE PAGES

Brune, C. R.; Caggiano, J. A.; Sayre, D. B.; ...

2015-07-20

An R-matrix model for three-body final states is presented and applied to a recent measurement of the neutron energy spectrum from the 3H + 3H→ 2n + α reaction. The calculation includes the n alpha and n n interactions in the final state, angular momentum conservation, antisymmetrization, and the interference between different channels. A good fit to the measured spectrum is obtained, where clear evidence for the 5He ground state is observed. The model is also used to predict the alpha-particle spectrum from 3H + 3H as well as particle spectra from 3He + 3He. The R-matrix approach presented heremore » is very general, and can be adapted to a wide variety of problems with three-body final states.« less

Disposal of olive mill wastewater with DC arc plasma method.

PubMed

Ibrahimoglu, Beycan; Yilmazoglu, M Zeki

2018-07-01

Olive mill wastewater is an industrial waste, generated as a byproduct of olive oil production process and generally contains components such as organic matter, suspended solids, oil, and grease. Although various methods have been developed to achieve the disposal of this industrial wastewater, due to the low cost, the most common disposal application is the passive storage in the lagoons. The main objective of this study is to reduce pollution parameters in olive mill wastewater and draw water to discharge limits by using plasma technology. Plasma-assisted disposal of olive mill wastewater method could be an alternative disposal technique when considering potential utilization of treated water in agricultural areas and economic value of flammable plasma gas which is the byproduct of disposal process. According to the experimental results, the rates of COD (chemical oxygen demand) and BOD (biological oxygen demand) of olive mill wastewater are decreased by 94.42% and 95.37%, respectively. The dissolved oxygen amount is increased from 0.36 to 6.97 mg/l. In addition, plasma gas with high H 2 content and treated water that can be used in agricultural areas for irrigation are obtained from non-dischargeable wastewater. Copyright © 2018 Elsevier Ltd. All rights reserved.

Activated Carbon-Based System for the Disposal of Psychoactive Medications

PubMed Central

Song, Yang; Manian, Mahima; Fowler, William; Korey, Andrew; Kumar Banga, Ajay

2016-01-01

The misuse and improper disposal of psychoactive medications is a major safety and environmental concern. Hence, the proper disposal of these medications is critically important. A drug deactivation system which contains activated carbon offers a unique disposal method. In the present study, deactivation efficiency of this system was tested by using three model psychoactive drugs. HPLC validation was performed for each drug to ensure that the analytical method employed was suitable for its intended use. The method was found to be specific, accurate and precise for analyzing the drugs. The extent and rate of deactivation of the drugs was determined at several time points. After 28 days in the presence of activated carbon, the extent of leaching out of the drugs was evaluated. Deactivation started immediately after addition of the medications into the disposal pouches. Within 8 h, around 47%, 70% and 97% of diazepam, lorazepam and buprenorphine were adsorbed by the activated carbon, respectively. By the end of 28 days, over 99% of all drugs were deactivated. The desorption/leaching study showed that less than 1% of the active ingredients leached out from the activated carbon. Thus, this deactivation system can be successfully used for the disposal of psychoactive medications. PMID:27827989

40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

40 CFR 721.3031 - Boric acid (H3BO3), zinc salt (2=3).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Boric acid (H3BO3), zinc salt (2=3... Substances § 721.3031 Boric acid (H3BO3), zinc salt (2=3). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as boric acid (H3BO3), zinc salt (2=3) (PMN P...

Insertion of bentonite with Organometallic [Fe3O(OOC6H5)6(H2O)3(NO3).nH2O] as Adsorbent of Congo Red

NASA Astrophysics Data System (ADS)

Said, Muhammad; Paluta Utami, Hasja; Hayati, Ferlina

2018-01-01

The adsorption of Congo red using bentonite inserted organometallic has been investigated. The insertion bentonite was characterized using FT-IR Spectrophotometer, XRD and XRF analysis. The FT-IR characterization showed the higher intensity of peak wavenumber at 470.6 cm-1 for Fe3O on the ratio 1:3. While the XRD characterization showed the shift of diffraction angle of 2θ was 5.2° and has a basal spacing of 16.8 Å. In the XRF characterization, the insertion process of organometallic occurred optimally with the percentage of metal oxide reached 71.75 %. The adsorption process of bentonite inserted organometallic compound [Fe3O(OOC6H5)6(H2O)3(NO3)·nH2O] showed the adsorption rate (k) is 0.050 min-1, the largest adsorption capacity (b) at 70°C is 4.48 mol/g, the largest adsorption energy at temperature 30°C which is 6.4 kJ/mol Organometallic compounds. The value of the enthalpy (ΔH) and entropy (ΔS) decreased with increasing concentrations of the Congo red. Effect of pH on the adsorption on at pH 3 shows the biggest of number Congo red absorbed is 19.52 mg/L for insertion of bentonite.

Laboratory Measurements for H3+ Deuteration Reactions

NASA Astrophysics Data System (ADS)

Bowen, Kyle; Hillenbrand, Pierre-Michel; Urbain, Xavier; Savin, Daniel Wolf

2018-06-01

Deuterated molecules are important chemical tracers of protostellar cores. At the ~106 cm-3 particle densities and ~20 K temperatures typical for protostellar cores, most molecules freeze onto dust grains. A notable exception is H3+ and its isotopologues. These become important carriers of positive charge in the gas, can couple to any ambient magnetic field, and can thereby alter the cloud dynamics. Knowing the total abundance of H3+ and its isotopologues is important for studying the evolution of protostellar cores. However, H3+ and D3+ have no dipole moment. They lack a pure rotational spectrum and are not observable at protostellar core temperatures. Fortunately H2D+ and D2H+ have dipole moments and a pure rotational spectrum that can be excited in protostellar cores. Observations of these two molecules, combined with astrochemical models, provide information about the total abundance of H3+ and all its isotopologues. The inferred abundances, though, rely on accurate astrochemical data for the deuteration of H3+ and its isotopologues.Here we present laboratory measurements of the rate coefficients for three important deuterating reactions, namely D + H3+/H2D+/D2H+ → H + H2D+/ D2H+/D3+. Astrochemical models currently rely on rate coefficients from classical (Langevin) or semi-classical methods for these reactions, as fully quantum-mechanical calculations are beyond current computational capabilities. Laboratory studies are the most tractable means of providing the needed data. For our studies we used our novel dual-source, merged fast-beams apparatus, which enables us to study reactions of neutral atoms and molecular ions. Co-propagating beams allow us to measure experimental rate coefficients as a function of collision energy. We extract cross section data from these results, which we then convolve with a Maxwell-Boltzmann distribution to generate thermal rate coefficients. Here we present our results for these three reactions and discuss some implications.

Development of a Universal Canister for Disposal of High-Level Waste in Deep Boreholes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, Laura L.; Gomberg, Steve

2015-11-01

The mission of the United States Department of Energy’s Office of Environmental Management is to complete the safe cleanup of the environmental legacy brought about from five decades of nuclear weapons development and government-sponsored nuclear energy research. Some of the wastes that must be managed have been identified as good candidates for disposal in a deep borehole in crystalline rock. In particular, wastes that can be disposed of in a small package are good candidates for this disposal concept. A canister-based system that can be used for handling these wastes during the disposition process (i.e., storage, transfer, transportation, and disposal)more » could facilitate the eventual disposal of these wastes. Development of specifications for the universal canister system will consider the regulatory requirements that apply to storage, transportation, and disposal of the capsules, as well as operational requirements and limits that could affect the design of the canister (e.g., deep borehole diameter). In addition, there are risks and technical challenges that need to be recognized and addressed as Universal Canister system specifications are developed. This paper provides an approach to developing specifications for such a canister system that is integrated with the overall efforts of the DOE’s Used Fuel Disposition Campaign's Deep Borehole Field Test and compatible with planned storage of potential borehole-candidate wastes.« less

PRN 83-3: Label Improvement Program - Storage and Disposal Label Statements

EPA Pesticide Factsheets

This Notice is to inform all registrants that the label of all pesticide products must include updated storage and disposal statements. No application for amended registration is required if you use the exact wording contained in this Notice.

Bismuth-Based, Disposable Sensor for the Detection of Hydrogen Sulfide Gas.

PubMed

Rosolina, Samuel M; Carpenter, Thomas S; Xue, Zi-Ling

2016-02-02

A new sensor for the detection of hydrogen sulfide (H2S) gas has been developed to replace commercial lead(II) acetate-based test papers. The new sensor is a wet, porous, paper-like substrate coated with Bi(OH)3 or its alkaline derivatives at pH 11. In contrast to the neurotoxic lead(II) acetate, bismuth is used due to its nontoxic properties, as Bi(III) has been a reagent in medications such as Pepto-Bismol. The reaction between H2S gas and the current sensor produces a visible color change from white to yellow/brown, and the sensor responds to ≥ 30 ppb H2S in a total volume of 1.35 L of gas, a typical volume of human breath. The alkaline, wet coating helps the trapping of acidic H2S gas and its reaction with Bi(III) species, forming colored Bi2S3. The sensor is suitable for testing human bad breath and is at least 2 orders of magnitude more sensitive than a commercial H2S test paper based on Pb(II)(acetate)2. The small volume of 1.35-L H2S is important, as the commercial Pb(II)(acetate)2-based paper requires large volumes of 5 ppm H2S gas. The new sensor reported here is inexpensive, disposable, safe, and user-friendly. A simple, laboratory setup for generating small volumes of ppb-ppm of H2S gas is also reported.

Ab-initio study of the energetics and thermodynamics of the reaction CH3H + O( 3P) → CF3H … O → CF3 + OH

NASA Astrophysics Data System (ADS)

Kreye, W. C.

1996-07-01

Ab-initio computations at 298.15 K were made of the activation quantities ΔH ‡, ΔS ‡, and ΔG ‡ and of the reaction quantities ΔHr and ΔSr for CF3H + O( 3P) → CF3H … O → .CF3.OH. CF 3H … O is the transition state (TS). GAUSSIAN92 was used and energies computed at a slightly modified Gaussian-2 level. Two potential surfaces for the TS had symmetries 3A' and 3A″. The two rate constants included a semi-classical, quantum-mechanical-tunneling transmission coefficient. The ab-initio ΔH ‡and ΔH r values were in excellent agreement (± 1 kcal/mol) with experiment; but the ΔS ‡, ΔG ‡, and ΔS r values yielded somewhat poorer agreement. Experimental and ab-initio structures were in excellent agreement.

INDIVIDUAL DOSIMETRY IN DISPOSAL REPOSITORY OF HEAT-GENERATING NUCLEAR WASTE.

PubMed

Pang, Bo; Saurí Suárez, Héctor; Becker, Frank

2016-09-01

Certain working scenarios in a disposal facility of heat-generating nuclear waste might lead to an enhanced level of radiation exposure for workers in such facilities. Hence, a realistic estimation of the personal dose during individual working scenarios is desired. In this study, the general-purpose Monte Carlo N-Particle code MCNP6 (Pelowitz, D. B. (ed). MCNP6 user manual LA-CP-13-00634, Rev. 0 (2013)) was applied to simulate a representative radiation field in a disposal facility. A tool to estimate the personal dose was then proposed by taking into account the influence of individual motion sequences during working scenarios. As basis for this approach, a movable whole-body phantom was developed to describe individual body gestures of the workers during motion sequences. In this study, the proposed method was applied to the German concept of geological disposal in rock salt. The feasibility of the proposed approach was demonstrated with an example of working scenario in an emplacement drift of a rock salt mine. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

30 CFR 817.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Disposal of excess spoil: Durable rock fills...-UNDERGROUND MINING ACTIVITIES § 817.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 816.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Disposal of excess spoil: Durable rock fills...-SURFACE MINING ACTIVITIES § 816.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 817.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Disposal of excess spoil: Durable rock fills...-UNDERGROUND MINING ACTIVITIES § 817.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 817.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Disposal of excess spoil: Durable rock fills...-UNDERGROUND MINING ACTIVITIES § 817.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 817.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Disposal of excess spoil: Durable rock fills...-UNDERGROUND MINING ACTIVITIES § 817.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 817.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Disposal of excess spoil: Durable rock fills...-UNDERGROUND MINING ACTIVITIES § 817.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 816.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Disposal of excess spoil: Durable rock fills...-SURFACE MINING ACTIVITIES § 816.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 816.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Disposal of excess spoil: Durable rock fills...-SURFACE MINING ACTIVITIES § 816.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 816.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Disposal of excess spoil: Durable rock fills...-SURFACE MINING ACTIVITIES § 816.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

30 CFR 816.73 - Disposal of excess spoil: Durable rock fills.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Disposal of excess spoil: Durable rock fills...-SURFACE MINING ACTIVITIES § 816.73 Disposal of excess spoil: Durable rock fills. The regulatory authority may approve the alternative method of disposal of excess durable rock spoil by gravity placement in...

Plastic Membrane Sensor from a Disposed Combined Glass Electrode

ERIC Educational Resources Information Center

Marafie, Hayat M.; Shoukry, Adel F.; Alshatti, Laila A.

2007-01-01

The construction of combined plastic membrane electrode for hydralazinium cation from a disposed glass electrode is described. A variety of electrodes could be prepared by students using other types of polymers, plasticizers, or exchangers which could also help to study effects of pH and temperature, or environmental investigations.

CAL3JHH: a Java program to calculate the vicinal coupling constants (3J H,H) of organic molecules.

PubMed

Aguirre-Valderrama, Alonso; Dobado, José A

2008-12-01

Here, we present a free web-accessible application, developed in the JAVA programming language for the calculation of vicinal coupling constant (3J(H,H)) of organic molecules with the H-Csp3-Csp3-H fragment. This JAVA applet is oriented to assist chemists in structural and conformational analyses, allowing the user to calculate the averaged 3J(H,H) values among conformers, according to its Boltzmann populations. Thus, the CAL3JHH program uses the Haasnoot-Leeuw-Altona equation, and, by reading the molecule geometry from a protein data bank (PDB) file format or from multiple pdb files, automatically detects all the coupled hydrogens, evaluating the data needed for this equation. Moreover, a "Graphical viewer" menu allows the display of the results on the 3D molecule structure, as well as the plotting of the Newman projection for the couplings.

Fully printed flexible and disposable wireless cyclic voltammetry tag.

PubMed

Jung, Younsu; Park, Hyejin; Park, Jin-Ah; Noh, Jinsoo; Choi, Yunchang; Jung, Minhoon; Jung, Kyunghwan; Pyo, Myungho; Chen, Kevin; Javey, Ali; Cho, Gyoujin

2015-01-29

A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep wave from +500 mV to -500 mV which enable to scan a printed electrochemical cell in the CV tag. By simply dropping any specimen solution on the electrochemical cell in the CV tag, the presence of solutes in the solution can be detected and shown on the signage of the CV tag in five sec. 10 mM of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) was used as a standard solute to prove the working concept of fully printed disposable wireless CV tag. Within five seconds, we can wirelessly diagnose the presence of TMPD in the solution using the CV tag in the proximity of the 13.56 MHz RF reader. This fully printed and wirelessly operated flexible CV tag is the first of its kind and marks the path for the utilization of inexpensive and disposable wireless electrochemical sensor systems for initial diagnose hazardous chemicals and biological molecules to improve public hygiene and health.

Fully printed flexible and disposable wireless cyclic voltammetry tag

NASA Astrophysics Data System (ADS)

Jung, Younsu; Park, Hyejin; Park, Jin-Ah; Noh, Jinsoo; Choi, Yunchang; Jung, Minhoon; Jung, Kyunghwan; Pyo, Myungho; Chen, Kevin; Javey, Ali; Cho, Gyoujin

2015-01-01

A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep wave from +500 mV to -500 mV which enable to scan a printed electrochemical cell in the CV tag. By simply dropping any specimen solution on the electrochemical cell in the CV tag, the presence of solutes in the solution can be detected and shown on the signage of the CV tag in five sec. 10 mM of N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) was used as a standard solute to prove the working concept of fully printed disposable wireless CV tag. Within five seconds, we can wirelessly diagnose the presence of TMPD in the solution using the CV tag in the proximity of the 13.56 MHz RF reader. This fully printed and wirelessly operated flexible CV tag is the first of its kind and marks the path for the utilization of inexpensive and disposable wireless electrochemical sensor systems for initial diagnose hazardous chemicals and biological molecules to improve public hygiene and health.

Disposable stainless steel vs plastic laryngoscope blades among paramedics.

PubMed

Dos Santos, Frank D; Schnakofsky, Roberto; Cascio, Anthony; Liu, Junfeng; Merlin, Mark A

2011-07-01

Several studies have been published in the literature about intubation methods, but little is available on intubation equipment used in this setting. This is the first prehospital comparison of disposable plastic vs disposable stainless steel laryngoscope blades used by paramedics. The objective of this study was to compare prehospital intubation success rates on first attempt and overall number of attempts to obtain intubations using disposable plastic laryngoscopes blades vs disposable stainless steel laryngoscope blades. A retrospective prehospital cohort study was conducted during two 3-year periods. Two-way contingency table and χ(2) test were conducted to determine if there was a difference between the 2 types of blades. A proportional odds model with calculated 95% confidence interval (CI) and odd ratios were then calculated. A total of 2472 paramedic intubations were recorded over the 6-year period. The stainless steel single-use blades had a first attempt success rate of 88.9% vs 78.5% with plastic blades (P = .01; odds ratio, 1.94; 95% CI, 1.17-3.41). The stainless steel single-use laryngoscope blade had a lower number of attempts to successful intubation than the plastic blade (88.8% vs 74.3%, respectively) (P < .01; odds ratio, 1.64; 95% CI, 1.34-2.00). In the prehospital setting, stainless steel disposable blades were superior to plastic disposable blades in first attempt and overall number of attempts to intubation. Until further research is done, we recommend use of stainless steel blades for intubations in the prehospital setting by paramedics. Copyright © 2011 Elsevier Inc. All rights reserved.

Influence of disposable, concentric needle electrodes on muscle enzyme and lactate serum levels.

PubMed

Finsterer, Josef; Mittendorfer, Bettina; Neuhuber, Werner; Löscher, Wolfgang N

2002-08-01

Several studies addressed the question whether needle-EMG causes elevation of muscle enzymes [aspartate-aminotransferase, alanine-aminotransferase, lactate-dehydrogenase, creatine-phosphokinase (CPK), isoenzyme-MB, aldolase] and lactate with conflicting results. However, these studies used sterilizable needle electrodes and different protocols and methods to record EMGs and determine muscle enzymes. This study examined if muscle enzymes are elevated immediately after or 24 h following EMGs with disposable, concentric needle-electrodes, and if they are dependent on age, sex, muscle, number of investigated sites and previous CPK-elevation. In 53 subjects, 24 woman, 29 men, aged 17-88 years, muscle enzymes were determined before, immediately after and 24 h following EMG with disposable, concentric needle-electrodes. Muscle enzymes were not different before, immediately after and 24 h following the EMG. Muscle enzymes were not different between patients 60 years of age. Apart from higher CPK in men than women, muscle enzymes were not different between the genders. Apart from CPK, muscle enzymes were not different between the brachial biceps and anterior tibial muscle. Muscle enzymes were not different if 20 sites were investigated and were independent on pre-EMG CPK-levels. In conclusion this study shows that muscle enzymes do not increase immediately or 24 h following EMG with disposable, concentric needle-electrodes, irrespective of age, gender, muscle, number of investigated sites and pre-EMG CK-levels.

Microchannel Reactor System Design & Demonstration For On-Site H2O2 Production by Controlled H2/O2 Reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adeniyi Lawal

whole industry as a result of our technology demonstration, our production concept is expected to save >5 trillion Btu/year of steam usage and >3 trillion Btu/year in electric power consumption. Our analysis also indicates >50 % reduction in waste disposal cost and ~10% reduction in feedstock energy. These savings translate to ~30% reduction in overall production and transportation costs for the $1B annual H2O2 market.« less

Lab-scale evaluation of aerated burial concept for treatment and emergency disposal of infectious animal carcasses.

PubMed

Koziel, Jacek A; Ahn, Heekwon; Glanville, Thomas D; Frana, Timothy S; van Leeuwen, J Hans; Nguyen, Lam T

2018-06-01

Nearly 55,000 outbreaks of animal disease were reported to the World Animal Health Information Database between 2005 and 2016. To suppress the spread of disease, large numbers of animal mortalities often must be disposed of quickly and are frequently buried on the farm where they were raised. While this method of emergency disposal is fast and relatively inexpensive, it also can have undesirable and lasting impacts (slow decay, concerns about groundwater contamination, pathogens re-emergence, and odor). Following the 2010 foot-and-mouth disease outbreak, the Republic of Korea's National Institute of Animal Science funded research on selected burial alternatives or modifications believed to have potential to reduce undesirable impacts of burial. One such modification involves the injection of air into the liquid degradation products from the 60-70% water from decomposing carcasses in lined burial trenches. Prior to prototype development in the field, a laboratory-scale study of aerated decomposition (AeD) of poultry carcasses was conducted to quantify improvements in time of carcass decomposition, reduction of potential groundwater pollutants in the liquid products of decomposition (since trench liners may ultimately leak), and reduction of odorous VOCs emitted during decomposition. Headspace gases also were monitored to determine the potential for using gaseous biomarkers in the aerated burial trench exhaust stream to monitor completion of the decomposition. Results of the lab-scale experiments show that the mass of chicken carcasses was reduced by 95.0 ± 0.9% within 3 months at mesophilic temperatures (vs. negligible reduction via mesophilic anaerobic digestion typical of trench burial) with concomitant reduction of biochemical oxygen demand (BOD; 99%), volatile suspended solids (VSS; 99%), total suspended solids (TSS; 99%), and total ammonia nitrogen (TAN; 98%) in the liquid digestate. At week #7 BOD and TSS in digestate met the U.S. EPA standards for

Sanitization and Disposal of Excess Information Technology Equipment

DTIC Science & Technology

2009-09-21

Report No. D-2009-104 September 21, 2009 Sanitization and Disposal of Excess Information Technology Equipment...2009 2. REPORT TYPE 3. DATES COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Sanitization and Disposal of Excess Information Technology ...Defense (Networks and Information Integration)/DOD Chief Information Officer DRMS Defense Reutilization and Marketing Service IT Information

Heat Treatment. Sludge Treatment and Disposal Course #166. Instructor's Guide [and] Student Workbook.

ERIC Educational Resources Information Center

Filer, Herb; Broste, Dale

This lesson was developed for a course in sludge treatment and disposal. The lesson describes the Porteous heat treatment method of sludge conditioning and compares that system to the Zimpro wet air oxidation process. The theory of heat treatment, system of components and functions, and concepts of operation are addressed in the lesson. The…

Evaluating pharmaceutical waste disposal in pediatric units.

PubMed

Almeida, Maria Angélica Randoli de; Wilson, Ana Maria Miranda Martins; Peterlini, Maria Angélica Sorgini

2016-01-01

To verify the disposal of pharmaceutical waste performed in pediatric units. A descriptive and observational study conducted in a university hospital. The convenience sample consisted of pharmaceuticals discarded during the study period. Handling and disposal during preparation and administration were observed. Data collection took place at pre-established times and was performed using a pre-validated instrument. 356 drugs disposals were identified (35.1% in the clinic, 31.8% in the intensive care unit, 23.8% in the surgical unit and 9.3% in the infectious diseases unit). The most discarded pharmacological classes were: 22.7% antimicrobials, 14.8% electrolytes, 14.6% analgesics/pain killers, 9.5% diuretics and 6.7% antiulcer agents. The most used means for disposal were: sharps' disposable box with a yellow bag (30.8%), sink drain (28.9%), sharps' box with orange bag (14.3%), and infectious waste/bin with a white bag (10.1%). No disposal was identified after drug administration. A discussion of measures that can contribute to reducing (healthcare) waste volume with the intention of engaging reflective team performance and proper disposal is necessary. Verificar o descarte dos resíduos de medicamentos realizado em unidades pediátricas. Estudo descritivo e observacional, realizado em um hospital universitário. A amostra de conveniência foi constituída pelos medicamentos descartados durante o período de estudo. Observaram-se a manipulação e o descarte durante o preparo e a administração. A coleta dos dados ocorreu em horários preestabelecidos e realizada por meio de instrumento pré-validado. Identificaram-se 356 descartes de medicamentos (35,1% na clínica, 31,8% na unidade de cuidados intensivos, 23,8% na cirúrgica e 9,3% na infectologia). As classes farmacológicas mais descartadas foram: 22,7% antimicrobianos, 14,8% eletrólitos, 14,6% analgésicos, 9,5% diuréticos e 6,7% antiulcerosos. Vias mais utilizadas: caixa descartável para perfurocortante com

Experiences in improving the state of the practice in verification and validation of knowledge-based systems

NASA Technical Reports Server (NTRS)

Culbert, Chris; French, Scott W.; Hamilton, David

1994-01-01

Knowledge-based systems (KBS's) are in general use in a wide variety of domains, both commercial and government. As reliance on these types of systems grows, the need to assess their quality and validity reaches critical importance. As with any software, the reliability of a KBS can be directly attributed to the application of disciplined programming and testing practices throughout the development life-cycle. However, there are some essential differences between conventional software and KBSs, both in construction and use. The identification of these differences affect the verification and validation (V&V) process and the development of techniques to handle them. The recognition of these differences is the basis of considerable on-going research in this field. For the past three years IBM (Federal Systems Company - Houston) and the Software Technology Branch (STB) of NASA/Johnson Space Center have been working to improve the 'state of the practice' in V&V of Knowledge-based systems. This work was motivated by the need to maintain NASA's ability to produce high quality software while taking advantage of new KBS technology. To date, the primary accomplishment has been the development and teaching of a four-day workshop on KBS V&V. With the hope of improving the impact of these workshops, we also worked directly with NASA KBS projects to employ concepts taught in the workshop. This paper describes two projects that were part of this effort. In addition to describing each project, this paper describes problems encountered and solutions proposed in each case, with particular emphasis on implications for transferring KBS V&V technology beyond the NASA domain.

Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis)

PubMed Central

Saade, Evelyne; Pirozhkova, Iryna; Aimbetov, Rakhan; Lipinski, Marc; Ogryzko, Vasily

2015-01-01

The H3.3 histone variant has been a subject of increasing interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication independent unlike the replication-coupled deposition of its canonical counterparts H3.1/2. Second, H3.3 has been consistently associated with an active state of chromatin. In accordance, this histone variant should be expected to be causally involved in the regulation of gene expression, or more generally, its incorporation should have downstream consequences for the structure and function of chromatin. This, however, leads to an apparent paradox: In cells that slowly replicate in the organism, H3.3 will accumulate with time, opening the way to aberrant effects on heterochromatin. Here, we review the indications that H3.3 is expected both to be incorporated in the heterochromatin of slowly replicating cells and to retain its functional downstream effects. Implications for organismal aging are discussed. PMID:25720734

41 CFR 109-45.5104-2 - Methods of disposal.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Methods of disposal. 109-45.5104-2 Section 109-45.5104-2 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS UTILIZATION AND DISPOSAL...

3-Helium in Obscure H II Regions

NASA Astrophysics Data System (ADS)

Bania, T. M.; Rood, R. T.; Balser, D. S.

1999-05-01

The light isotope of helium, (3) He, can serve as a probe of cosmology, the evolution of low mass stars, and the chemical evolution of the Galaxy. Its abundance can be determined via measurements of the 3.46 cm hyperfine transition of (3) He(+) . Potentially observable sources of ionized gas include H ii regions and planetary nebulae. The selection of (3) He targets is counter-intuitive because the (3) He(+) hyperfine line strength is proportional to the source density, while one usually thinks of H ii regions in terms of radio continuum or recombination line strength both of which depend on the square of the density. The (3) He(+) line strength depends on the (3) He(+) abundance ratio and a number of other factors: $ TL(A}({) (3) He(+)) ~ frac {N((3) He(+)}{N() H(+)}) frac {({TC(A}}D)({1/2)) Te(1/4) (theta_obs (2) - theta_beam (2})({3/4}}{Delta {v}({)) (3) He(+)) [ln(5.717 x 10(-3}Te({3/2})]^{1/2)) theta_obs } where T_L^A and Delta v are the antenna temperature and FWHM of the ^3He^+ line, D is the nebular distance, T_C^A and theta_obs are the antenna temperature and observed FWHM angular size of the continuum emission, theta_beam is the telescope's FWHM beam, and Te is the nebular electron temperature. For H {sc ii} regions much larger than the telescope beam we can select targets using the criterion: TLA(^3He^+)\\sim\\sqrt{TCA D\\theta_obs}. This is the case since we can neglect the weak dependence on T_e and because we do not know either ^3He^{+}/H^+ or Delta v. Thus big, distant H ii regions could be potential ^3He^+ targets even if their continuum emission is weak. Armed with this knowledge we included H ii regions like S209 in our early observing list along with more famous sources like W43. Still we did not have the temerity to push this reasoning to the limit. We have now found, however, that this selection criterion is valid for even the wimpiest known H ii regions. Here we report on the detection of ^3He^+$ emission in 8 distant, low density H ii regions.

Minimum dV for Targeted Spacecraft Disposal

NASA Technical Reports Server (NTRS)

Bacon, John B.

2017-01-01

The study analyzes the minimum capability required to dispose safely of a space object. The study considers 3- sigma environmental uncertainties, as well as spacecraft-specific constraints such as the available thrust, total impulse, the achievable increase or decrease in commandable frontal area under stable attitude (or stable tumble), and the final controllable altitude at which any such dV may be imparted. The study addresses the definition of the length and location of a 'safe' disposal area, which is a statistical manifestation of uncertainty in this process. Some general legal concerns are raised that are unique to this prospect of low dV disposals. Future work is summarized. The goal of such research is to improve public safety by creating optimally safe disposal strategies (and potentially, applicable regulations) for low-dV and/or low-thrust spacecraft that under more traditional strategies would need to be abandoned to fully-random decay with its inherent higher risk of human casualty.

Nqrs Data for H4I3Li2NO9 [H4INO3·2(ILiO3)] (Subst. No. 2278)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for H4I3Li2NO9 [H4INO3·2(ILiO3)] (Subst. No. 2278)

Nqrs Data for H6I3InO12 [I3InO9·3(H2O)] (Subst. No. 2289)

NASA Astrophysics Data System (ADS)

Chihara, H.; Nakamura, N.

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for H6I3InO12 [I3InO9·3(H2O)] (Subst. No. 2289)

Al6H18: A baby crystal of γ-AlH3

NASA Astrophysics Data System (ADS)

Kiran, B.; Kandalam, Anil K.; Xu, Jing; Ding, Y. H.; Sierka, M.; Bowen, K. H.; Schnöckel, H.

2012-10-01

Using global-minima search methods based on the density functional theory calculations of (AlH3)n (n = 1-8) clusters, we show that the growth pattern of alanes for n ≥ 4 is dominated by structures containing hexa-coordinated Al atoms. This is in contrast to the earlier studies where either linear or ring structures of AlH3 were predicted to be the preferred structures in which the Al atoms can have a maximum of five-fold coordination. Our calculations also reveal that the Al6H18 cluster, with its hexa-coordination of the Al atoms, resembles the unit-cell of γ-AlH3, thus Al6H18 is designated as the "baby crystal." The fragmentation energies of the (AlH3)n (n = 2-8) along with the dimerization energies for even n clusters indicate an enhanced stability of the Al6H18 cluster. Both covalent (hybridization) and ionic (charge) contribution to the bonding are the driving factors in stabilizing the isomers containing hexa-coordinated Al atoms.

Concept development of a Mach 3.0 high-speed civil transport

NASA Technical Reports Server (NTRS)

Robins, A. Warner; Dollyhigh, Samuel M.; Beissner, Fred L., Jr.; Geiselhart, Karl; Martin, Glenn L.; Shields, E. W.; Swanson, E. E.; Coen, Peter G.; Morris, Shelby J., Jr.

1988-01-01

A baseline concept for a Mach 3.0 high-speed civil transport concept was developed as part of a national program with the goal that concepts and technologies be developed which will enable an effective long-range high-speed civil transport system. The Mach 3.0 concept reported represents an aggressive application of advanced technology to achieve the design goals. The level of technology is generally considered to be that which could have a demonstrated availability date of 1995 to 2000. The results indicate that aircraft are technically feasible that could carry 250 passengers at Mach 3.0 cruise for a 6500 nautical mile range at a size, weight and performance level that allows it to fit into the existing world airport structure. The details of the configuration development, aerodynamic design, propulsion system design and integration, mass properties, mission performance, and sizing are presented.

Uptake of /sup 3/H-choline and synthesis of /sup 3/H-acetylcholine by human penile corpus cavernosum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanco, R.; Saenz de Tejada, I.; Azadzoi, K.

1986-03-05

The neuroeffectors which relax penile smooth muscle and lead to erection are unknown; physiological studies of human corpus cavernosum, in vitro, have suggested a significant role of cholinergic neurotransmission. To further characterize the importance of cholinergic nerves, biopsies of human corpus cavernosum were obtained at the time of penile prosthesis implantation. Tissues were incubated in /sup 3/H-choline (10/sup -5/M, 80 Ci/mmol) in oxygenated physiological salt solution at 37/sup 0/C, pH 7.4 for 1 hour. Radiolabelled compounds were extracted with perchloric acid (0.4 M) and acetylcholine and choline were separated by HPLC; /sup 14/C-acetylcholine was used as internal standard. /sup 3/H-cholinemore » was accumulated by the tissues (20 +/- 1.9 fmol/mg), and /sup 3/H-acetylcholine was synthesized (4.0 +/- 1.1 fmol/mg). In control experiments, heating of the tissue blocked synthesis of /sup 3/H-acetylcholine. Inhibition of high affinity choline transport by hemicholinium-3 (10/sup -5/M) diminished tissue accumulation of /sup 3/H-choline and significantly reduced the synthesis of /sup 3/H-acetylcholine (0.5 +/ 0.2 fmol/mg, p < 0.05). These results provide direct evidence of neuronal accumulation of choline and enzymatic conversion to acetylcholine in human corpus cavernosum. Taken together with the physiological studies, it can be concluded that cholinergic neurotransmission in human corpus cavernosum plays a role in penile erection.« less

The 3H(d,gamma) Reaction and the 3 H(d,gamma)/ 3H(d, n) Branching Ratio for Ec.m. 300 keV

NASA Astrophysics Data System (ADS)

Parker, Cody E.

The 3H(d, gamma)5He reaction and the 3H(d, gamma)/3H(d, n) branching ratio have been measured using a 500-keV pulsed deuteron beam incident on a titanium tritide target of stopping thickness at the Edwards Accelerator Laboratory. The time-of-flight technique has been used to distinguish the gamma-rays from neutrons in the bismuth germinate (BGO) gamma-ray detector. A stilbene scintillator and an NE-213 scintillator have been used to detect the neutrons from the 3H(d, n)alpha reaction using both the pulse-shape discrimination and time-of-flight techniques. A target holder with an ion-implanted silicon detector at a fixed angle of 135° to the beam axis to simultaneously measure alpha-particles as a normalization for the number of neutrons was incorporated to reduce the uncertainty in the neutron yield over the preliminary measurement. The gamma-rays have been measured at laboratory angles of 0°, 4°, 9°, and 15°. Information about the gamma-ray energy distribution for the unbound ground state and first excited state of 5He have been obtained experimentally by comparing the BGO data to Monte Carlo simulations. The reported branching ratios for each angle contain only contributions from the ground-state gamma-ray branch.

pH regulation in anoxic rice coleoptiles at pH 3.5: biochemical pHstats and net H+ influx in the absence and presence of NO3−

PubMed Central

Greenway, Hank; Kulichikhin, Konstantin Y.; Cawthray, Gregory R.; Colmer, Timothy D.

2012-01-01

During anoxia, cytoplasmic pH regulation is crucial. Mechanisms of pH regulation were studied in the coleoptile of rice exposed to anoxia and pH 3.5, resulting in H+ influx. Germinating rice seedlings survived a combination of anoxia and exposure to pH 3.5 for at least 4 d, although development was retarded and net K+ efflux was continuous. Further experiments used excised coleoptile tips (7–10 mm) in anoxia at pH 6.5 or 3.5, either without or with 0.2 mM NO3−, which distinguished two processes involved in pH regulation. Net H+ influx (μmol g−1 fresh weight h−1) for coleoptiles with NO3− was ∼1.55 over the first 24 h, being about twice that in the absence of NO3−, but then decreased to 0.5–0.9 as net NO3− uptake declined from ∼1.3 to 0.5, indicating reduced uptake via H+–NO3− symports. NO3− reduction presumably functioned as a biochemical pHstat. A second biochemical pHstat consisted of malate and succinate, and their concentrations decreased substantially with time after exposure to pH 3.5. In anoxic coleoptiles, K+ balancing the organic anions was effluxed to the medium as organic anions declined, and this efflux rate was independent of NO3− supply. Thus, biochemical pHstats and reduced net H+ influx across the plasma membrane are important features contributing to pH regulation in anoxia-tolerant rice coleoptiles at pH 3.5. PMID:22174442

Metallization of aluminum hydride AlH3 at high multiple-shock pressures

NASA Astrophysics Data System (ADS)

Molodets, A. M.; Shakhray, D. V.; Khrapak, A. G.; Fortov, V. E.

2009-05-01

A study of electrophysical and thermodynamic properties of alane AlH3 under multishock compression has been carried out. The increase in specific electroconductivity of alane at shock compression up to pressure 100 GPa has been measured. High pressures and temperatures were obtained with an explosive device, which accelerates the stainless impactor up to 3 km/s. A strong shock wave is generated on impact with a holder containing alane. The impact shock is split into a shock wave reverberating in alane between two stiff metal anvils. This compression loads the alane sample by a multishock manner up to pressure 80-90 GPa, heats alane to the temperature of about 1500-2000 K, and lasts 1μs . The conductivity of shocked alane increases in the range up to 60-75 GPa and is about 30(Ωcm)-1 . In this region the semiconductor regime is true for shocked alane. The conductivity of alane achieves approximately 500(Ωcm)-1 at 80-90 GPa. In this region, conductivity is interpreted in frames of the conception of the “dielectric catastrophe,” taking into consideration significant differences between the electronic states of isolated molecule AlH3 and condensed alane.

Synthetic, Infrared, 1H and 13C NMR Spectral Studies on N-(2-/3-Substituted Phenyl)-4-Substituted Benzenesulphonamides, 4-X'C6H4SO2NH(2-/3-XC6H4), where X' = H, CH3, C2H5, F, Cl or Br, and X = CH3 or Cl

NASA Astrophysics Data System (ADS)

Gowda, B. Thimme; Shetty, Mahesha; Jayalakshmi, K. L.

2005-02-01

Twenty three N-(2-/3-substituted phenyl)-4-substituted benzenesulphonamides of the general formula, 4-X'C6H4SO2NH(2-/3-XC6H4), where X' = H, CH3, C2H5, F, Cl or Br and X = CH3 or Cl have been prepared and characterized, and their infrared spectra in the solid state, 1H and 13C NMR spectra in solution were studied. The N-H stretching vibrations, νN-H, absorb in the range 3285 - 3199 cm-1, while the asymmetric and symmetric SO2 vibrations vary in the ranges 1376 - 1309 cm-1 and 1177 - 1148 cm-1, respectively. The S-N and C-N stretching vibrations absorb in the ranges 945 - 893 cm-1 and 1304 - 1168 cm-1, respectively. The compounds do not exhibit particular trends in the variation of these frequencies on substitution either at ortho or meta positions with either a methyl group or Cl. The observed 1H and 13C chemical shifts of are assigned to protons and carbons of the two benzene rings. Incremental shifts of the ring protons and carbons due to -SO2NH(2-/3-XC6H4) groups in C6H5SO2NH(2-/3-XC6H4), and 4- X'C6H4SO2- and 4-X'C6H4SO2NH- groups in 4-X'C6H4SO2NH(C6H5) are computed and employed to calculate the chemical shifts of the ring protons and carbons in the substituted compounds, 4-X'C6H4SO2NH(2-/3-XC6H4). The computed values agree well with the observed chemical shifts.

Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis).

PubMed

Saade, Evelyne; Pirozhkova, Iryna; Aimbetov, Rakhan; Lipinski, Marc; Ogryzko, Vasily

2015-06-01

The H3.3 histone variant has been a subject of increasing interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication independent unlike the replication-coupled deposition of its canonical counterparts H3.1/2. Second, H3.3 has been consistently associated with an active state of chromatin. In accordance, this histone variant should be expected to be causally involved in the regulation of gene expression, or more generally, its incorporation should have downstream consequences for the structure and function of chromatin. This, however, leads to an apparent paradox: In cells that slowly replicate in the organism, H3.3 will accumulate with time, opening the way to aberrant effects on heterochromatin. Here, we review the indications that H3.3 is expected both to be incorporated in the heterochromatin of slowly replicating cells and to retain its functional downstream effects. Implications for organismal aging are discussed. © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Two new three-dimensional zinc phosphites templated by piperazine: [H2pip][Zn3(HPO3)4(H2O)2] and K[H2pip]0.5[Zn3(HPO3)4

NASA Astrophysics Data System (ADS)

Zhang, Xiao; Wang, Guo-Ming; Wang, Zong-Hua; Wang, Ying-Xia; Lin, Jian-Hua

2014-01-01

Two three-dimensional open-framework zinc phosphites with the same organically templated, [H2pip][Zn3(HPO3)4(H2O)2] (1) and K[H2pip]0.5[Zn3(HPO3)4] (2) (pip = piperazine), have been solvothermally synthesized and structurally characterized by IR, elemental analysis, thermogravimetric analysis, powder and single-crystal X-ray diffractions. Compound 1 consists of ZnO4 tetrahedra, [HPO3] pseudopyramids and [ZnO4(H2O)2] octahedra, which are linked through their vertexes to generate three-dimensional architecture with intersecting 8-membered channels along the [1 0 0], [0 0 1] and [1 0 1] directions. Compound 2 is constructed from strictly alternating ZnO4 tetrahedra and [HPO3] pseudopyramids, and exhibits (3,4)-connected inorganic framework with 8-, and 12-membered channels, in which the K+ and diprotonated H2pip2+ extra-framework cations reside, respectively. The coexistence of inorganic K+ and organic piperazine mixed templates in the structure is unique and, to the best of our knowledge, firstly observed in metal-phosphite materials. In addition, the participation of left-handed and right-handed helical chains in construction of the puckered 4.82 sheet structure in 2 is also noteworthy.

Formation of stable uranium(VI) colloidal nanoparticles in conditions relevant to radioactive waste disposal.

PubMed

Bots, Pieter; Morris, Katherine; Hibberd, Rosemary; Law, Gareth T W; Mosselmans, J Frederick W; Brown, Andy P; Doutch, James; Smith, Andrew J; Shaw, Samuel

2014-12-09

The favored pathway for disposal of higher activity radioactive wastes is via deep geological disposal. Many geological disposal facility designs include cement in their engineering design. Over the long term, interaction of groundwater with the cement and waste will form a plume of a hyperalkaline leachate (pH 10-13), and the behavior of radionuclides needs to be constrained under these extreme conditions to minimize the environmental hazard from the wastes. For uranium, a key component of many radioactive wastes, thermodynamic modeling predicts that, at high pH, U(VI) solubility will be very low (nM or lower) and controlled by equilibrium with solid phase alkali and alkaline-earth uranates. However, the formation of U(VI) colloids could potentially enhance the mobility of U(VI) under these conditions, and characterizing the potential for formation and medium-term stability of U(VI) colloids is important in underpinning our understanding of U behavior in waste disposal. Reflecting this, we applied conventional geochemical and microscopy techniques combined with synchrotron based in situ and ex situ X-ray techniques (small-angle X-ray scattering and X-ray adsorption spectroscopy (XAS)) to characterize colloidal U(VI) nanoparticles in a synthetic cement leachate (pH > 13) containing 4.2-252 μM U(VI). The results show that in cement leachates with 42 μM U(VI), colloids formed within hours and remained stable for several years. The colloids consisted of 1.5-1.8 nm nanoparticles with a proportion forming 20-60 nm aggregates. Using XAS and electron microscopy, we were able to determine that the colloidal nanoparticles had a clarkeite (sodium-uranate)-type crystallographic structure. The presented results have clear and hitherto unrecognized implications for the mobility of U(VI) in cementitious environments, in particular those associated with the geological disposal of nuclear waste.

Space disposal of nuclear wastes

NASA Technical Reports Server (NTRS)

Priest, C. C.; Nixon, R. F.; Rice, E. E.

1980-01-01

The DOE has been studying several options for nuclear waste disposal, among them space disposal, which NASA has been assessing. Attention is given to space disposal destinations noting that a circular heliocentric orbit about halfway between Earth and Venus is the reference option in space disposal studies. Discussion also covers the waste form, showing that parameters to be considered include high waste loading, high thermal conductivity, thermochemical stability, resistance to leaching, fabrication, resistance to oxidation and to thermal shock. Finally, the Space Shuttle nuclear waste disposal mission profile is presented.

Sludge Treatment, Utilization, and Disposal.

ERIC Educational Resources Information Center

Dick, Richard I.

1978-01-01

Presents the 1978 literature review of wastewater treatment. This review covers such areas: (1) industrial and hazardous sludges; (2) chemical sludges; (3) stabilization and combustion; (4) ocean disposal; and (5) land application. A list of 411 references is also presented. (HM)

Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron.

PubMed Central

Steward, L. J.; Ge, J.; Bentley, K. R.; Barber, P. C.; Hope, A. G.; Lambert, J. J.; Peters, J. A.; Blackburn, T. P.; Barnes, N. M.

1995-01-01

1. The radioligand binding characteristics of the 3H-derivative of the novel 5-HT3 receptor antagonist BRL46470 were investigated and directly compared to the well characterized 5-HT3 receptor radioligand [3H]-granisetron, in tissue homogenates prepared from rat cerebral cortex/hippocampus, rat ileum, NG108-15 cells, HEK-5-HT3As cells and human putamen. 2. In rat cerebral cortex/hippocampus, rat ileum, NG108-15 cell and HEK-5-HT3As cell homogenates, [3H]-BRL46470 bound with high affinity (Kd (nM): 1.57 +/- 0.18, 2.49 +/- 0.30, 1.84 +/- 0.27, 3.46 +/- 0.36, respectively; mean +/- s.e. mean, n = 3-4) to an apparently homogeneous saturable population of sites (Bmax (fmol mg-1 protein): 102 +/- 16, 44 +/- 4, 968 +/- 32 and 2055 +/- 105, respectively; mean +/- s.e. mean, n = 3-4) but failed to display specific binding in human putamen homogenates. 3. In the same homogenates of rat cerebral cortex/hippocampus, rat ileum, NG108-15 cells, HEK-5-HT3As cells and human putamen as used for the [3H]-BRL46470 studies, [3H]-granisetron also bound with high affinity (Kd (nM): 1.55 +/- 0.61, 2.31 +/- 0.44, 1.89 +/- 0.36, 2.03 +/- 0.42 and 6.46 +/- 2.58 respectively; mean +/- s.e. mean, n = 3-4) to an apparently homogeneous saturable population of sites (Bmax (fmol mg-1 protein): 39 +/- 4, 20 +/- 2, 521 +/- 47, 870 +/- 69 and 18 +/- 2, respectively; mean +/- s.e. mean, n = 3-4).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8528560

Disposal of Vessels at Sea

EPA Pesticide Factsheets

Vessel disposal general permits are issued by the EPA under the Marine Protection, Research and Sanctuaries Act. Information is provided for vessel disposal permit applicants and where to dispose a vessel.

Efficacy of NH3 as a secondary barrier treatment for inactivation of Salmonella Typhimurium and methicillin-resistant Staphylococcus aureus in digestate of animal carcasses: Proof-of-concept

PubMed Central

2017-01-01

Managing the disposal of infectious animal carcasses from routine and catastrophic disease outbreaks is a global concern. Recent research suggests that burial in lined and aerated trenches provides the rapid pathogen containment provided by burial, while reducing air and water pollution potential and the length of time that land is taken out of agricultural production. Survival of pathogens in the digestate remains a concern, however. A potential answer is a ‘dual’-barrier approach in which ammonia is used as a secondary barrier treatment to reduce the risk of pathogen contamination when trench liners ultimately leak. Results of this study showed that the minimum inhibitory concentration (MIC) of NH3 is 0.1 M (~1,468 NH3-N mg/L), and 0.5 M NH3 (~7,340 NH3-N mg/L) for ST4232 & MRSA43300, respectively at 24 h and pH = 9±0.1 and inactivation was increased by increasing NH3 concentration and/or treatment time. Results for digestate treated with NH3 were consistent with the MICs, and both pathogens were completely inactivated within 24 h. PMID:28475586

The inhibition of marine nitrification by ocean disposal of carbon dioxide.

PubMed

Huesemann, Michael H; Skillman, Ann D; Crecelius, Eric A

2002-02-01

In an attempt to reduce the threat of global warming, it has been proposed that the rise of atmospheric carbon dioxide concentrations be reduced by the ocean disposal of CO2 from the flue gases of fossil fuel-fired power plants. The release of large amounts of CO2 into mid or deep ocean waters will result in large plumes of acidified seawater with pH values ranging from 6 to 8. In an effort to determine whether these CO2-induced pH changes have any effect on marine nitrification processes, surficial (euphotic zone) and deep (aphotic zone) seawater samples were sparged with CO2 for varying time durations to achieve a specified pH reduction, and the rate of microbial ammonia oxidation was measured spectrophotometrically as a function of pH using an inhibitor technique. For both seawater samples taken from either the euphotic or aphotic zone, the nitrification rates dropped drastically with decreasing pH. Relative to nitrification rates in the original seawater at pH 8, nitrification rates were reduced by ca. 50% at pH 7 and more than 90% at pH 6.5. Nitrification was essentially completely inhibited at pH 6. These findings suggest that the disposal of CO2 into mid or deep oceans will most likely result in a drastic reduction of ammonia oxidation rates within the pH plume and the concomitant accumulation of ammonia instead of nitrate. It is unlikely that ammonia will reach the high concentration levels at which marine aquatic organisms are known to be negatively affected. However, if the ammonia-rich seawater from inside the pH plume is upwelled into the euphotic zone, it is likely that changes in phytoplankton abundance and community structure will occur. Finally, the large-scale inhibition of nitrification and the subsequent reduction of nitrite and nitrate concentrations could also result in a decrease of denitrification rates which, in turn, could lead to the buildup of nitrogen and unpredictable eutrophication phenomena. Clearly, more research on the environmental

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

PubMed

Pittalà, Valeria; Romeo, Giuseppe; Salerno, Loredana; Siracusa, Maria Angela; Modica, Maria; Materia, Luisa; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana; Marucci, Gabriella; Angeli, Piero; Russo, Filippo

2006-01-01

The discovery of a new series of selective and high-affinity alpha(1)-adrenoceptor (alpha(1)-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for alpha(1)-ARs and substantial selectivity with respect to 5-HT(1A) and dopaminergic D(1) and D(2) receptors. Functional assays, performed on selected derivatives, showed antagonistic properties.

Synthesis of 3,5-Isoxazolidinediones and 1H-2,3-Benzoxazine-1,4(3H)-diones from Aliphatic Oximes and Dicarboxylic Acid Chlorides

PubMed Central

2015-01-01

The synthesis of the title compounds was carried out by reacting dicarboxylic acid chlorides with oximes in the presence of excess triethylamine. Disubstituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a–f) and 2,2′-ethylidene-bis[4,4-dialkyl-3,5-isoxazolidinedione]s (9a–f). Compounds 9 were formed from 8 and its N-unsubstituted 3,5-isoxazolidinedione decomposition product. Phthaloyl chlorides reacted with acetone oxime to yield 3-(1-methylethenyl)-1H-2,3-benzoxazine-1,4(3H)-diones (16a–e). Products 16 spontaneously decomposed to give N-unsubstituted 1H-2,3-benzoxazine-1,4(3H)-diones (17a–e) at rates that were dependent on temperature and solvent. Kinetic studies showed that two of the compounds decomposed by zero-order kinetics under neutral conditions. Butanedioyl chloride did not produce a cyclic product. PMID:24620711

Synthesis of 3,5-isoxazolidinediones and 1H-2,3-benzoxazine-1,4(3H)-diones from aliphatic oximes and dicarboxylic acid chlorides.

PubMed

Izydore, Robert A; Jones, Joseph T; Mogesa, Benjamin; Swain, Ira N; Davis-Ward, Ronda G; Daniels, Dwayne L; Kpakima, Felicia Frazier; Spaulding-Phifer, Sharnelle T

2014-04-04

The synthesis of the title compounds was carried out by reacting dicarboxylic acid chlorides with oximes in the presence of excess triethylamine. Disubstituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a-f) and 2,2'-ethylidene-bis[4,4-dialkyl-3,5-isoxazolidinedione]s (9a-f). Compounds 9 were formed from 8 and its N-unsubstituted 3,5-isoxazolidinedione decomposition product. Phthaloyl chlorides reacted with acetone oxime to yield 3-(1-methylethenyl)-1H-2,3-benzoxazine-1,4(3H)-diones (16a-e). Products 16 spontaneously decomposed to give N-unsubstituted 1H-2,3-benzoxazine-1,4(3H)-diones (17a-e) at rates that were dependent on temperature and solvent. Kinetic studies showed that two of the compounds decomposed by zero-order kinetics under neutral conditions. Butanedioyl chloride did not produce a cyclic product.

Arabidopsis kinetochore null2 is an upstream component for centromeric histone H3 variant cenH3 deposition at centromeres.

PubMed

Lermontova, Inna; Kuhlmann, Markus; Friedel, Swetlana; Rutten, Twan; Heckmann, Stefan; Sandmann, Michael; Demidov, Dmitri; Schubert, Veit; Schubert, Ingo

2013-09-01

The centromeric histone H3 variant cenH3 is an essential centromeric protein required for assembly, maintenance, and proper function of kinetochores during mitosis and meiosis. We identified a kinetochore null2 (KNL2) homolog in Arabidopsis thaliana and uncovered features of its role in cenH3 loading at centromeres. We show that Arabidopsis KNL2 colocalizes with cenH3 and is associated with centromeres during all stages of the mitotic cell cycle, except from metaphase to mid-anaphase. KNL2 is regulated by the proteasome degradation pathway. The KNL2 promoter is mainly active in meristematic tissues, similar to the cenH3 promoter. A knockout mutant for KNL2 shows a reduced level of cenH3 expression and reduced amount of cenH3 protein at chromocenters of meristematic nuclei, anaphase bridges during mitosis, micronuclei in pollen tetrads, and 30% seed abortion. Moreover, knl2 mutant plants display reduced expression of suppressor of variegation 3-9 homologs2, 4, and 9 and reduced DNA methylation, suggesting an impact of KNL2 on the epigenetic environment for centromere maintenance.

30 CFR 816.89 - Disposal of noncoal mine wastes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... underground water. Wastes shall be routinely compacted and covered to prevent combustion and wind-borne waste... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Disposal of noncoal mine wastes. 816.89 Section... ACTIVITIES § 816.89 Disposal of noncoal mine wastes. (a) Noncoal mine wastes including, but not limited to...

30 CFR 817.89 - Disposal of noncoal mine wastes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... underground water. Wastes shall be routinely compacted and covered to prevent combustion and wind-borne waste... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Disposal of noncoal mine wastes. 817.89 Section... ACTIVITIES § 817.89 Disposal of noncoal mine wastes. (a) Noncoal mine wastes including, but not limited to...

Expansion of antimonato polyoxovanadates with transition metal complexes: (Co(N3C5H15)2)2[{Co(N3C5H15)2}V15Sb6O42(H2O)]·5H2O and (Ni(N3C5H15)2)2[{Ni(N3C5H15)2}V15Sb6O42(H2O)]·8H2O.

PubMed

Antonova, Elena; Näther, Christian; Kögerler, Paul; Bensch, Wolfgang

2012-02-20

Two new polyoxovanadates (Co(N(3)C(5)H(15))(2))(2)[{Co(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)]·5H(2)O (1) and (Ni(N(3)C(5)H(15))(2))(2)[{Ni(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)]·8H(2)O (2) (N(3)C(5)H(15) = N-(2-aminoethyl)-1,3-propanediamine) were synthesized under solvothermal conditions and structurally characterized. In both structures the [V(15)Sb(6)O(42)(H(2)O)](6-) shell displays the main structural motif, which is strongly related to the {V(18)O(42)} archetype cluster. Both compounds crystallize in the triclinic space group P1 with a = 14.3438(4), b = 16.6471(6), c = 18.9186(6) Å, α = 87.291(3)°, β = 83.340(3)°, γ = 78.890(3)°, and V = 4401.4(2) Å(3) (1) and a = 14.5697(13), b = 15.8523(16), c = 20.2411(18) Å, α = 86.702(11)°, β = 84.957(11)°, γ = 76.941(11)°, and V = 4533.0(7) Å(3) (2). In the structure of 1 the [V(15)Sb(6)O(42)(H(2)O)](6-) cluster anion is bound to a [Co(N(3)C(5)H(15))(2)](2+) complex via a terminal oxygen atom. In the Co(2+)-centered complex, one of the amine ligands coordinates in tridentate mode and the second one in bidentate mode to form a strongly distorted CoN(5)O octahedron. Similarly, in compound 2 an analogous NiN(5)O complex is joined to the [V(15)Sb(6)O(42)(H(2)O)](6-) anion via the same attachment mode. A remarkable difference between the two compounds is the orientation of the noncoordinated propylamine group leading to intermolecular Sb···O contacts in 1 and to Sb···N interactions in 2. In the solid-state lattices of 1 and 2, two additional [M(N(3)C(5)H(15))(2)](2+) complexes act as countercations and are located between the [{M(N(3)C(5)H(15))(2)}V(15)Sb(6)O(42)(H(2)O)](4-) anions. Between the anions and cations strong N-H···O hydrogen bonds are observed. In both compounds the clusters are stacked along the b axis in an ABAB fashion with cations and water molecules occupying the space between the clusters. Magnetic characterization demonstrates that the Ni(2+) and Co(2+) cations do not

On the Automation of the MarkIII Data Analysis System.

NASA Astrophysics Data System (ADS)

Schwegmann, W.; Schuh, H.

1999-03-01

A faster and semiautomatic data analysis is an important contribution to the acceleration of the VLBI procedure. A concept for the automation of one of the most widely used VLBI software packages the MarkIII Data Analysis System was developed. Then, the program PWXCB, which extracts weather and cable calibration data from the station log-files, was automated supplementing the existing Fortran77 program-code. The new program XLOG and its results will be presented. Most of the tasks in the VLBI data analysis are very complex and their automation requires typical knowledge-based techniques. Thus, a knowledge-based system (KBS) for support and guidance of the analyst is being developed using the AI-workbench BABYLON, which is based on methods of artificial intelligence (AI). The advantages of a KBS for the MarkIII Data Analysis System and the required steps to build a KBS will be demonstrated. Examples about the current status of the project will be given, too.

Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability

NASA Astrophysics Data System (ADS)

Sabater, David; Arriarán, Sofía; Romero, María Del Mar; Agnelli, Silvia; Remesar, Xavier; Fernández-López, José Antonio; Alemany, Marià

2014-01-01

White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation.

Investigations of the unsaturated zone at two radioactive waste disposal sites in Lithuania.

PubMed

Skuratovič, Žana; Mažeika, Jonas; Petrošius, Rimantas; Martma, Tõnu

2016-01-01

The unsaturated zone is an important part of the water cycle, governed by many hydrological and hydrogeological factors and processes and provide water and nutrients to the terrestrial ecosystem. Besides, the soils of the unsaturated zone are regarded as the first natural barrier to a large extent and are able to limit the spread of contaminants depending on their properties. The unsaturated zone provides a linkage between atmospheric moisture, groundwater, and seepage of groundwater to streams, lakes, or other surface water bodies. The major difference between water flow in saturated and unsaturated soils is that the hydraulic conductivity, which is conventionally assumed to be a constant in saturated soils, is a function of the degree of saturation or matrix suction in the unsaturated soils. In Lithuania, low and intermediate level radioactive wastes generated from medicine, industry and research were accumulated at the Maisiagala radioactive waste repository. Short-lived low and intermediate levels radioactive waste, generated during the operation of the Ignalina Nuclear Power Plant (INPP) and arising after the INPP decommissioning will be disposed of in the near surface repository close to the INPP (Stabatiske site). Extensive data sets of the hydraulic properties and water content attributed to unsaturated zone soil profiles of the two radioactive waste disposal sites have been collected and summarized. Globally widespread radionuclide tritium ((3)H) and stable isotope ratio ((18)O/(16)O and (2)H/(1)H) distribution features were determined in precipitation, unsaturated zone soil moisture profiles and groundwater.

An eco friendly solution to the food waste disposal

NASA Astrophysics Data System (ADS)

Babu, G. Reddy; Kumar, G. Madhav

2017-07-01

In recent years, waste disposal at workmen camp is one of the major problems being faced by many nations across the world. In the workmen colony at Chittapur, a series of kitchens were built for cooking purpose and a number of small canteens are also functioning. Considerable quantity of food waste is collected daily from these eateries and disposed at a faraway place. Food waste is highly degradable in nature, if not disposed properly it causes problems related to environmental pollution. Hence, it is very important to identify an environment friendly process rather than opt for land filling or any disposal method. We worked together to find a suitable eco-friendly solution for the food waste disposal at Chittapur site and suggested that biogas production through anaerobic digestion is a solution for the disposal and utilization of food waste for better purpose. This resulted in setting up a 500 kg per day food waste treatment biogas plant at Chittapur. This establishment is the first time in the construction industry at workmen camp in India. Anaerobic Digestion has been recognized as one of the best options that is available for treating food waste, as it generates two valuable end products, biogas and compost. Biogas is a mixture of CH4 and CO2 about (55:45). Biogas generated can be used for thermal applications such as cooking or for generating electricity. The digested slurry is a well stabilized organic manure and can be used as soil fertilizer. Plant design is to handle 500 kg of food waste /day. 27 kg LPG is obtained from 500kg of kitchen waste. The Value of 27 kg of LPG is Rs.2700/day. Daily 1000 litres of digested effluent was obtained. It is good organic manure with plant micro nutrients and macro nutrients. This can be used for growing plants and in agriculture. The value of manure per day is Rs.250/-. The annual revenue is Rs.10.62 lakhs and the annual expenditure is 1.8 lakhs. The net benefit is 8.82 lakhs. Payback period is 2.1 years. This process

Disposal of spent fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blomeke, J O; Ferguson, D E; Croff, A G

1978-01-01

Based on preliminary analyses, spent fuel assemblies are an acceptable form for waste disposal. The following studies appear necessary to bring our knowledge of spent fuel as a final disposal form to a level comparable with that of the solidified wastes from reprocessing: 1. A complete systems analysis is needed of spent fuel disposition from reactor discharge to final isolation in a repository. 2. Since it appears desirable to encase the spent fuel assembly in a metal canister, candidate materials for this container need to be studied. 3. It is highly likely that some ''filler'' material will be needed betweenmore » the fuel elements and the can. 4. Leachability, stability, and waste-rock interaction studies should be carried out on the fuels. The major disadvantages of spent fuel as a disposal form are the lower maximum heat loading, 60 kW/acre versus 150 kW/acre for high-level waste from a reprocessing plant; the greater long-term potential hazard due to the larger quantities of plutonium and uranium introduced into a repository; and the possibility of criticality in case the repository is breached. The major advantages are the lower cost and increased near-term safety resulting from eliminating reprocessing and the treatment and handling of the wastes therefrom.« less

Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008 - 2011).

PubMed

Ferreira, Vitor F; da Rocha, David R; da Silva, Fernando C; Ferreira, Patrícia G; Boechat, Núbia A; Magalhães, Jorge L

2013-03-01

The triazoles represent a class of five-membered heterocyclic compounds of great importance for the preparation of new drugs with diverse biological activities because they may present several structural variations with the same numbers of carbon and nitrogen atoms. Due to the success of various triazoles that entered the pharmaceutical market and are still being used in medicines, many companies and research groups have shown interest in developing new methods of synthesis and biological evaluation of potential uses for these compounds. In this review, the authors explored aspects of patents for the 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole families, including prototypes being considered in clinical studies between 2008 and 2011. The triazoles have been studied for over a century as an important class of heterocyclic compounds and still attract considerable attention due to their broad range of biological activities. More recently, there has been considerable interest in the development of novel triazoles with anti-inflammatory, antiplatelet, antimicrobial, antimycobacterial, antitumoral and antiviral properties and activity against several neglected diseases. This review emphasizes recent perspective and advances in the therapeutically active 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivative patents between 2008 and 2011, covering the development of new chemical entities and new pharmaceuticals. Many studies have focused on these compounds as target structures and evaluated them in several biological targets. The preparation of 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives brings to light several issues. There is a need to find new, more efficient preparations for these triazoles that take into consideration current issues in green chemistry, energy saving and sustainability. New diseases are discovered and new viruses and bacteria continue to challenge mankind, so it is imperative to find new prototypes for these

Energy and Spectroscopic Characterization of the Isomers of C4H3-, C6H3-, and C6H5-

NASA Technical Reports Server (NTRS)

Wright, Danielle; Bera, Partha P.; Lee, Timothy J.

2015-01-01

Organic and inorganic molecules, neutral and ions have been observed in the interstellar medium. A few anions of organic molecules have also been observed recently. The Cassini spacecraft in the upper atmosphere of Titan has observed anions of large organic molecules. In this project we have studied the physical and spectroscopic properties of C4H3-, C6H3-, and C6H5-. We have optimized the geometrical structures of all low-lying isomers of the anions, calculated rotational, and harmonic vibrational frequencies of the anions mentioned above using the B3LYP density functional along with the augmented correlation consistent polar valence triple zeta (aug-cc-pVTZ) basis set. We have found many low-lying isomers on the potential energy surface of these anions.

Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.

PubMed

Ray, Anirban; Bandyopadhyay, Amitabha; Matsumoto, Tomohiro; Deng, Haiteng; Maitra, Umadas

2008-11-01

The fission yeast Schizosaccharomyces pombe homologue of the p40/eIF3h subunit of mammalian translation initiation factor eIF3 has been characterized in this study. We show that this protein physically associates with the 40S ribosomal particles as a constituent of the multimeric eIF3 protein complex, which consists of all five known eIF3 core subunits (eIF3a, eIF3b, eIF3c, eIF3g and eIF3i) as well as the five non-core subunits (eIF3d, eIF3e, eIF3f, eIF3h and eIF3m) that constitute an eIF3 holocomplex in fission yeast. However, affinity purification of eIF3 from fission yeast cells expressing TAP-tagged eIF3h suggests the presence of distinct forms of eIF3 that differ in their composition of the non-core subunits. Further characterization of eIF3h shows that strains lacking eif3h(+) (eif3hDelta) are viable and show no gross defects, either in vegetative growth or in the rate of in vivo protein synthesis. Polysome profile analysis shows no apparent defects in translation initiation. Furthermore, deletion of eif3h(+) does not affect the ability of the other eIF3 subunits to remain associated with one another in a tight protein complex similar to the situation in wild-type cells. Additionally, we show that human eIF3h can functionally substitute fission yeast eIF3h in complementing in vivo a genetic deletion of eif3h(+). Interestingly, mutant eif3hDelta cells show several prominent phenotypic properties. They are hypersensitive to caffeine and highly defective in meiosis, producing either no spores or incomplete tetrads with a very high frequency. The implications of these results in relation to the functions of eIF3h in Sz. pombe are discussed. (c) 2008 John Wiley & Sons, Ltd.

Space nuclear reactors — A post-operational disposal strategy

NASA Astrophysics Data System (ADS)

Angelo, Joseph A.; Buden, David

If 100-kWe and multimegawatt-electric class space nuclear reactors are to play a significant role in humanity's push into cislunar and heliocentric space in the next millennium, the obvious advantages of space nuclear power plants should not be denied to space mission planners due to a failure to develop internationally-acceptable post-operational disposal strategies for spent reactor cores. This is true whether the space reactor has shut down at the end of its normal mission lifetime or in response to an onboard system failure/emergency which causes a premature mission termination. Up until now the great majority of aerospace nuclear safety efforts have concentrated on prelaunch, launch and reactor startup activities. In fact, with the exception of the development of the "nuclear safe orbit" (NSO) concept, little technical attention has yet been given to the post-operational disposal of future space reactors. This paper describes the technical alternatives available for the safe, acceptable disposal of space reactors that could be used in a wide variety of space applications in the 21st Century. Post-operational core radioactivity levels for typical advanced design (hundred kWe-class) space reactors are presented as a function of decay time and contrasted to the spent core radionuclide inventory of the SNAP-10A system, the only nuclear reactor operated in space by the United States. The role of a permanent space station, smart robotic systems, and an operating lunar base in support of spent core disposal strategies is also presented, including use of a selected portion of the lunar surface as an internationally-designated spent reactor core repository.

Fully printed flexible and disposable wireless cyclic voltammetry tag

PubMed Central

Jung, Younsu; Park, Hyejin; Park, Jin-Ah; Noh, Jinsoo; Choi, Yunchang; Jung, Minhoon; Jung, Kyunghwan; Pyo, Myungho; Chen, Kevin; Javey, Ali; Cho, Gyoujin

2015-01-01

A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep wave from +500 mV to −500 mV which enable to scan a printed electrochemical cell in the CV tag. By simply dropping any specimen solution on the electrochemical cell in the CV tag, the presence of solutes in the solution can be detected and shown on the signage of the CV tag in five sec. 10 mM of N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD) was used as a standard solute to prove the working concept of fully printed disposable wireless CV tag. Within five seconds, we can wirelessly diagnose the presence of TMPD in the solution using the CV tag in the proximity of the 13.56 MHz RF reader. This fully printed and wirelessly operated flexible CV tag is the first of its kind and marks the path for the utilization of inexpensive and disposable wireless electrochemical sensor systems for initial diagnose hazardous chemicals and biological molecules to improve public hygiene and health. PMID:25630250

Proton transfer reactions and dynamics in CH(3)OH-H(3)O(+)-H(2)O complexes.

PubMed

Sagarik, Kritsana; Chaiwongwattana, Sermsiri; Vchirawongkwin, Viwat; Prueksaaroon, Supakit

2010-01-28

Proton transfer reactions and dynamics in hydrated complexes formed from CH(3)OH, H(3)O(+) and H(2)O were studied using theoretical methods. The investigations began with searching for equilibrium structures at low hydration levels using the DFT method, from which active H-bonds in the gas phase and continuum aqueous solution were characterized and analyzed. Based on the asymmetric stretching coordinates (Deltad(DA)), four H-bond complexes were identified as potential transition states, in which the most active unit is represented by an excess proton nearly equally shared between CH(3)OH and H(2)O. These cannot be definitive due to the lack of asymmetric O-H stretching frequencies (nu(OH)) which are spectral signatures of transferring protons. Born-Oppenheimer molecular dynamics (BOMD) simulations revealed that, when the thermal energy fluctuations and dynamics were included in the model calculations, the spectral signatures at nu(OH) approximately 1000 cm(-1) appeared. In continuum aqueous solution, the H-bond complex with incomplete water coordination at charged species turned out to be the only active transition state. Based on the assumption that the thermal energy fluctuations and dynamics could temporarily break the H-bonds linking the transition state complex and water molecules in the second hydration shell, elementary reactions of proton transfer were proposed. The present study showed that, due to the coupling among various vibrational modes, the discussions on proton transfer reactions cannot be made based solely on static proton transfer potentials. Inclusion of thermal energy fluctuations and dynamics in the model calculations, as in the case of BOMD simulations, together with systematic IR spectral analyses, have been proved to be the most appropriate theoretical approaches.

Gas generation behavior of transuranic waste under disposal conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujisawa, Ryutaro; Kurashige, Tetsunari; Inagaki, Yusuke

1999-07-01

The generation of hydrogen-gas from metallic waste is an important issue for the safety analysis of geological disposal facilities for transuranic (TRU) radioactive waste in Japan. The objective of this study is to clarify the gas-generation behavior of stainless steel and carbon steel in non-oxidizing alkaline synthetic groundwater (pH 12.8 and 10.5) at 30 C simulating geological disposal environments. At pH 12.8, the observed gas-generation rate from stainless steel in the initial period of immersion was 1.0 x 10{sup 2} Nml/m{sup 2}/y and 1.0 x 10 Nml/m{sup 2}/y after 200 days (N represents the standard state of gas at 0more » C and 1 atm). At pH 10.5, gas generation was not observed for 60 days in the initial period. At 60 days, the gas-generation observed was 5.0 x 10 NMl/m{sup 2}/y. After 250 days, the gas-generation rate approaches zero. At pH 12.8, the observed gas generation rate of carbon steel in the initial period of immersion was 1.5 x 10{sup 2} Nml/m{sup 2}/y and the gas generation rate began to decrease after 200 days. After 300 days, it was 25 Nml/m{sup 2}/y. At pH 10.5, the gas generation rate in the initial period was 5.0 x 10{sup 2} Nml/m{sup 2}/y and was 1.0 x 10 Nml/m{sup 2}/y after 200 days.« less

A wide-angle camera module for disposable endoscopy

NASA Astrophysics Data System (ADS)

Shim, Dongha; Yeon, Jesun; Yi, Jason; Park, Jongwon; Park, Soo Nam; Lee, Nanhee

2016-08-01

A wide-angle miniaturized camera module for disposable endoscope is demonstrated in this paper. A lens module with 150° angle of view (AOV) is designed and manufactured. All plastic injection-molded lenses and a commercial CMOS image sensor are employed to reduce the manufacturing cost. The image sensor and LED illumination unit are assembled with a lens module. The camera module does not include a camera processor to further reduce its size and cost. The size of the camera module is 5.5 × 5.5 × 22.3 mm3. The diagonal field of view (FOV) of the camera module is measured to be 110°. A prototype of a disposable endoscope is implemented to perform a pre-clinical animal testing. The esophagus of an adult beagle dog is observed. These results demonstrate the feasibility of a cost-effective and high-performance camera module for disposable endoscopy.

Modification of the histone tetramer at the H3-H3 interface impacts tetrasome conformations and dynamics

NASA Astrophysics Data System (ADS)

Ordu, Orkide; Kremser, Leopold; Lusser, Alexandra; Dekker, Nynke H.

2018-03-01

Nucleosomes consisting of a short piece of deoxyribonucleic acid (DNA) wrapped around an octamer of histone proteins form the fundamental unit of chromatin in eukaryotes. Their role in DNA compaction comes with regulatory functions that impact essential genomic processes such as replication, transcription, and repair. The assembly of nucleosomes obeys a precise pathway in which tetramers of histones H3 and H4 bind to the DNA first to form tetrasomes, and two dimers of histones H2A and H2B are subsequently incorporated to complete the complex. As viable intermediates, we previously showed that tetrasomes can spontaneously flip between a left-handed and right-handed conformation of DNA-wrapping. To pinpoint the underlying mechanism, here we investigated the role of the H3-H3 interface for tetramer flexibility in the flipping process at the single-molecule level. Using freely orbiting magnetic tweezers, we studied the assembly and structural dynamics of individual tetrasomes modified at the cysteines close to this interaction interface by iodoacetamide (IA) in real time. While such modification did not affect the structural properties of the tetrasomes, it caused a 3-fold change in their flipping kinetics. The results indicate that the IA-modification enhances the conformational plasticity of tetrasomes. Our findings suggest that subnucleosomal dynamics may be employed by chromatin as an intrinsic and adjustable mechanism to regulate DNA supercoiling.

A validation of the 3H/3He method for determining groundwater recharge

NASA Astrophysics Data System (ADS)

Solomon, D. K.; Schiff, S. L.; Poreda, R. J.; Clarke, W. B.

1993-09-01

Tritium and He isotopes have been measured at a site where groundwater flow is nearly vertical for a travel time of 100 years and where recharge rates are spatially variable. Because the mid-1960s 3H peak (arising from aboveground testing of thermonuclear devices) is well-defined, the vertical groundwater velocity is known with unusual accuracy at this site. Utilizing 3H and its stable daughter 3He to determine groundwater ages, we compute a recharge rate of 0.16 m/yr, which agrees to within about 5% of the value based on the depth of the 3H peak (measured both in 1986 and 1991) and two-dimensional modeling in an area of high recharge. Zero 3H/3He age occurs at a depth that is approximately equal to the average depth of the annual low water table, even though the capillary fringe extends to land surface during most of the year at the study site. In an area of low recharge (0.05 m/yr) where the 3H peak (and hence the vertical velocity) is also well-defined, the 3H/3He results could not be used to compute recharge because samples were not collected sufficiently far above the 3H peak; however, modeling indicates that the 3H/3He age gradient near the water table is an accurate measure of vertical velocities in the low-recharge area. Because 3H and 3He have different diffusion coefficients, and because the amount of mechanical mixing is different in the area of high recharge than in the low-recharge area, we have separated the dispersive effects of mechanical mixing from molecular diffusion. We estimate a longitudinal dispersivity of 0.07 m and effective diffusion coefficients for 3H (3HHO) and 3He of 2.4×10-5 and 1.3×10-4 m2/day, respectively. Although the 3H/3He age gradient is an excellent indicator of vertical groundwater velocities above the mid-1960s 3H peak, dispersive mixing and diffusive loss of 3He perturb the age gradient near and below the 3H peak.

CFD Growth of 3C-SiC on 4H/6H Mesas

NASA Technical Reports Server (NTRS)

Neudeck, Philip G.; Trunek, Andrew J.; Spry, David J.; Powell, J. Anthony; Du, Hui; Skowronski, Marek; Huang, XianRong; Dudley, Michael

2006-01-01

This article describes growth and characterization of the highest quality reproducible 3C-SiC heteroepitaxial films ever reported. By properly nucleating 3C-SiC growth on top of perfectly on-axis (0001) 4H-SiC mesa surfaces completely free of atomic scale steps and extended defects, growth of 3C-SiC mesa heterofilms completely free of extended crystal defects can be achieved. In contrast, nucleation and growth of 3C-SiC mesa heterofilms on top of 4H-SiC mesas with atomic-scale steps always results in numerous observable dislocations threading through the 3C-SiC epilayer. High-resolution X-ray diffraction and transmission electron microscopy measurements indicate non-trivial in-plane lattice mismatch between the 3C and 4H layers. This mismatch is somewhat relieved in the step-free mesa case via misfit dislocations confined to the 3C/4H interfacial region without dislocations threading into the overlying 3C-SiC layer. These results indicate that the presence or absence of steps at the 3C/4H heteroepitaxial interface critically impacts the quality, defect structure, and relaxation mechanisms of single-crystal heteroepitaxial 3C-SiC films.

Hydrogen Storage Properties of New Hydrogen-Rich BH3NH3-Metal Hydride (TiH2, ZrH2, MgH2, and/or CaH2) Composite Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Young Joon; Xu, Yimin; Shaw, Wendy J.

2012-04-19

Ammonia borane (AB = NH3BH3) is one of the most attractive materials for chemical hydrogen storage due to its high hydrogen contents of 19.6 wt.%, however, impurity levels of borazine, ammonia and diborane in conjunction with foaming and exothermic hydrogen release calls for finding ways to mitigate the decomposition reactions. In this paper we present a solution by mixing AB with metal hydrides (TiH2, ZrH2, MgH2 and CaH2) which have endothermic hydrogen release in order to control the heat release and impurity levels from AB upon decomposition. The composite materials were prepared by mechanical ball milling, and their H2 releasemore » properties were characterized by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The formation of volatile products from decomposition side reactions, such as borazine (N3B3H6) was determined by mass spectrometry (MS). Sieverts type pressure-composition-temperature (PCT) gas-solid reaction instrument was adopted to observe the kinetics of the H2 release reactions of the combined systems and neat AB. In situ 11B MAS-NMR revealed a destabilized decomposition pathway. We found that by adding specific metal hydrides to AB we can eliminate the impurities and mitigate the heat release.« less

Integrating Design and Manufacturing for a High Speed Civil Transport Wing

NASA Technical Reports Server (NTRS)

Marx, William J.; Mavris, Dimitri N.; Schrage, Daniel P.

1994-01-01

The aerospace industry is currently addressing the problem of integrating design and manufacturing. Because of the difficulties associated with using conventional, procedural techniques and algorithms, it is the authors' belief that the only feasible way to integrate the two concepts is with the development of an appropriate Knowledge-Based System (KBS). The authors propose a methodology for an aircraft producibility assessment, including a KBS, that addresses both procedural and heuristic aspects of integrating design and manufacturing of a High Speed Civil Transport (HSCT) wing. The HSCT was chosen as the focus of this investigation since it is a current NASA/aerospace industry initiative full of technological challenges involving many disciplines. The paper gives a brief background of selected previous supersonic transport studies followed by descriptions of key relevant design and manufacturing methodologies. Georgia Tech's Concurrent Engineering/Integrated Product and Process Development methodology is discussed with reference to this proposed conceptual producibility assessment. Evaluation criteria are presented that relate pertinent product and process parameters to overall product producibility. In addition, the authors' integration methodology and reasons for selecting a KBS to integrate design and manufacturing are presented in this paper. Finally, a proposed KBS is given, as well as statements of future work and overall investigation objectives.

Sources of Radium Accumulation in Stream Sediments near Disposal Sites in Pennsylvania: Implications for Disposal of Conventional Oil and Gas Wastewater.

PubMed

Lauer, Nancy E; Warner, Nathaniel R; Vengosh, Avner

2018-02-06

In Pennsylvania, Appalachian oil and gas wastewaters (OGW) are permitted for release to surface waters after some treatment by centralized waste treatment (CWT) facilities. While this practice was largely discontinued in 2011 for unconventional Marcellus OGW at facilities permitted to release high salinity effluents, it continues for conventional OGW. This study aimed to evaluate the environmental implications of the policy allowing the disposal of conventional OGW. We collected stream sediments from three disposal sites receiving treated OGW between 2014 and 2017 and measured 228 Ra, 226 Ra, and their decay products, 228 Th and 210 Pb, respectively. We consistently found elevated activities of 228 Ra and 226 Ra in stream sediments in the vicinity of the outfall (total Ra = 90-25,000 Bq/kg) compared to upstream sediments (20-80 Bq/kg). In 2015 and 2017, 228 Th/ 228 Ra activity ratios in sediments from two disposal sites were relatively low (0.2-0.7), indicating that a portion of the Ra has accumulated in the sediments in recent (<3) years, when no unconventional Marcellus OGW was reportedly discharged. 228 Ra/ 226 Ra activity ratios were also higher than what would be expected solely from disposal of low 228 Ra/ 226 Ra Marcellus OGW. Based on these variations, we concluded that recent disposal of treated conventional OGW is the source of high Ra in stream sediments at CWT facility disposal sites. Consequently, policies pertaining to the disposal of only unconventional fluids are not adequate in preventing radioactive contamination in sediments at disposal sites, and the permission to release treated Ra-rich conventional OGW through CWT facilities should be reconsidered.

Influence on Levels of Information as Presented by Different Technologies on Students' Understanding of Acid, Base, and pH Concepts.

ERIC Educational Resources Information Center

Nakhleh, Mary B.; Krajcik, Joseph S.

1994-01-01

Involves secondary students in a study designed to allow investigation into how different levels of information presented by various technologies (chemical indicators, pH meters, and microcomputer-based laboratories-MBLs) affected students' understanding of acid, base, and pH concepts. Results showed that students using MBLs exhibited a greater…

3D structure of a complex of transform basins from gravity data, a case study from the central Dead Sea fault

NASA Astrophysics Data System (ADS)

Rosenthal, Michal; Schattner, Uri; Ben-Avraham, Zvi

2017-04-01

The Kinneret-Bet She'an (KBS) basin complex comprises the Sea of Galilee, Kinarot, and Bet She'an sub-basins. The complex developed at the intersection between two major tectonic boundaries: the Oligo-Miocene Azraq-Sirhan failed rift, that later developed into the southern Galilee basins and Carmel-Gilboa fault system; and the Dead Sea fault (DSF) plate boundary that developed since the Miocene. Despite numerous studies, KBS still remains one of the enigmatic basin complexes. Its structure, stratigraphy and development are vaguely understood - both inside the basin and in correlation with its surroundings. Our study presents a new and comprehensive 3D model for the structure of KBS complex. It is based on all available gravity measurements, adopted from the national gravity database, and new gravity measurements, collected in cooperation with the Geological Survey of Israel and funded by the Ministry of National Infrastructure, Energy and Water Resources. The gravity data were integrated with constraints from boreholes, surface geology, seismic surveys, potential field studies and teleseismic tomography. The dense distribution of gravity data [1] provides suitable coverage for modeling the deep structure in three dimensions. The model details the spatial distribution, depth, thickness and density of the following regional units within the KBS complex and across its surroundings: upper crust, pre-Senonian sediments, Senonian and Cenozoic sediments, Miocene volcanics, Pliocene and Quaternary volcanics. Additional local units include salt, gabbro and pyroclasts. Results indicate that the KBS complex comprises two sub-basins separated by a structural saddle: Kinneret-Kinarot ( 6-7 km deep, 45 km long) and Bet She'an ( 4 km deep, 10 km long) sub-basin. A 500 m thick layer of Miocene volcanics appears across the Bet She'an sub-basin, yet missing from the Kinneret-Kinarot sub-basin. Between the basins Zemah-1 borehole penetrated a salt unit. The model indicates that this

Synthesis and fundamental properties of stable Ph(3)SnSiH(3) and Ph(3)SnGeH(3) hydrides: model compounds for the design of Si-Ge-Sn photonic alloys.

PubMed

Tice, Jesse B; Chizmeshya, Andrew V G; Groy, Thomas L; Kouvetakis, John

2009-07-06

The compounds Ph(3)SnSiH(3) and Ph(3)SnGeH(3) (Ph = C(6)H(5)) have been synthesized as colorless solids containing Sn-MH(3) (M = Si, Ge) moieties that are stable in air despite the presence of multiple and highly reactive Si-H and Ge-H bonds. These molecules are of interest since they represent potential model compounds for the design of new classes of IR semiconductors in the Si-Ge-Sn system. Their unexpected stability and high solubility also makes them a safe, convenient, and potentially useful delivery source of -SiH(3) and -GeH(3) ligands in molecular synthesis. The structure and composition of both compounds has been determined by chemical analysis and a range of spectroscopic methods including multinuclear NMR. Single crystal X-ray structures were determined and indicated that both compounds condense in a Z = 2 triclinic (P1) space group with lattice parameters (a = 9.7754(4) A, b = 9.8008(4) A, c = 10.4093(5) A, alpha = 73.35(10)(o), beta = 65.39(10)(o), gamma = 73.18(10)(o)) for Ph(3)SnSiH(3) and (a = 9.7927(2) A, b = 9.8005(2) A, c = 10.4224(2) A, alpha = 74.01(3)(o), beta = 65.48(3)(o), gamma = 73.43(3)(o)) for Ph(3)SnGeH(3). First principles density functional theory simulations are used to corroborate the molecular structures of Ph(3)SnSiH(3) and Ph(3)SnGeH(3), gain valuable insight into the relative stability of the two compounds, and provide correlations between the Si-Sn and Ge-Sn bonds in the molecules and those in tetrahedral Si-Ge-Sn solids.

Geological considerations in hazardouswaste disposal

NASA Astrophysics Data System (ADS)

Cartwright, K.; Gilkeson, R. H.; Johnson, T. M.

1981-12-01

Present regulations assume that long-term isolation of hazardous wastes — including toxic chemical, biological, radioactive, flammable and explosive wastes — may be effected by disposal in landfills that have liners of very low hydraulic conductivity. In reality, total isolation of wastes in humid areas is not possible; some migration of leachate from wastes buried in the gound will always occur. Regulations should provide performance standards applicable on a site-by-site basis rather than rigid criteria for site selection and design. The performance standards should take into account several factors: (1) the categories, segregation, degradation and toxicity of the wastes; (2) the site hydrogeology, which governs the direction and rate of contaminant transport; (3) the attenuation of contaminants by geochemical interactions with geologic materials; and (4) the release rate of unattenuated pollutants to surface or groundwater. An adequate monitoring system is essential. The system should both test the extent to which the operation of the site meets performance standards and provide sufficient warning of pollution problems to allow implementation of remedial measures. In recent years there has been a trend away from numerous, small disposal sites toward fewer and larger sites. The size of a disposal site should be based on the attenuation capacity of the geologic material, which has a finite, though generally not well-defined, limit. For slowly degradable wastes, engineered sites with leachate-collection systems appear to be only a temporary solution since the leachate collected will also require final disposal.

Geological considerations in hazardouswaste disposal

USGS Publications Warehouse

Cartwright, K.; Gilkeson, R.H.; Johnson, T.M.

1981-01-01

Present regulations assume that long-term isolation of hazardous wastes - including toxic chemical, biological, radioactive, flammable and explosive wastes - may be effected by disposal in landfills that have liners of very low hydraulic conductivity. In reality, total isolation of wastes in humid areas is not possible; some migration of leachate from wastes buried in the gound will always occur. Regulations should provide performance standards applicable on a site-by-site basis rather than rigid criteria for site selection and design. The performance standards should take into account several factors: (1) the categories, segregation, degradation and toxicity of the wastes; (2) the site hydrogeology, which governs the direction and rate of contaminant transport; (3) the attenuation of contaminants by geochemical interactions with geologic materials; and (4) the release rate of unattenuated pollutants to surface or groundwater. An adequate monitoring system is essential. The system should both test the extent to which the operation of the site meets performance standards and provide sufficient warning of pollution problems to allow implementation of remedial measures. In recent years there has been a trend away from numerous, small disposal sites toward fewer and larger sites. The size of a disposal site should be based on the attenuation capacity of the geologic material, which has a finite, though generally not well-defined, limit. For slowly degradable wastes, engineered sites with leachate-collection systems appear to be only a temporary solution since the leachate collected will also require final disposal. ?? 1981.

Dual-resolution modeling demonstrates greater conformational heterogeneity of CENP-A/H4 dimer than that of H3/H4

NASA Astrophysics Data System (ADS)

Zhao, Haiqing

Centromere protein A (CENP-A) is a centromere-specific H3 histone variant and shares only about 50% amino acid sequence identity with the canonical H3 protein. CENP-A is required for packaging the centromere and for the proper separation of chromosomes during mitosis. Despite their discrete functions, previously reported crystal structures of the CENP-A/H4 and H3/H4 dimers reveal surprising similarity. In this work, we characterize the structure and dynamics of CENP-A/H4 and H3/H4 dimers with a dual-resolution approach, using both all-atom and coarse-grained (CG) molecular dynamics (MD) simulations. Interestingly, the histone dimer containing CENP-A is more structurally variable than the canonical H3 dimer. Furthermore, our calculations revealed significant conformational distinctions between the interface profiles of CENP-A/H4 and H3/H4. In addition, the presence of the CENP-A-specific chaperone HJURP dramatically reduced the conformational heterogeneity of CENP-A/H4. Overall, these results are in general agreement with the available experimental data and provide new dynamic insights into the mechanisms underpinning the chaperone-mediated assembly of CENP-A nucleosomes in vivo.

Reducing infectious complications after transrectal prostate needle biopsy using a disposable needle guide: is it possible?

PubMed

Gurbuz, Cenk; Canat, Lutfi; Atis, Gokhan; Caskurlu, Turhan

2011-01-01

To investigate whether the use of a disposable needle guide results in a decreased incidence of infectious complication after transrectal prostate needle biopsy (TPNB). Fifty five patients who underwent 10-core TPNB were randomized into two groups. A pre-biopsy blood and urine examination was performed in both groups. Group 1 (25 patients) underwent biopsy with disposable biopsy needle guide and Group 2 (30 patients) underwent biopsy with reusable biopsy needle guide. All patients had a blood and negative urine culture before the procedure. The patients received ciprofloxacin 500 mg twice a day beginning the day before the biopsy and continued for 3 days after. Serum C-reactive protein levels and urine and blood specimens were obtained 48 h after the biopsy. Primary endpoint of the study was to determine the effect of needle guide on the bacteriologic urinary tract infection (UTI) rate and secondary end point was to determine symptomatic UTI. The mean age of the patients was 63.46 (range 55 to 68) years. There were no significant differences regarding the prostate-specific antigen level, prostate size, existence of comorbidity in two groups before the procedure. Bacteriologic and symptomatic UTI was detected in 4% vs. 6.6% and 4% vs. 3.9% in Group 1 and 2 relatively (P > 0.05). The use of a disposable needle guide does not appear to minimize infection risk after TPNB. Large scale and randomized studies are necessary to determine the effect of disposable needle guide on infection rate after TPNB.

The interconversion and disposal of ketone bodies in untreated and injured post-absorptive rats

PubMed Central

Barton, Roger N.

1973-01-01

[3-14C]Acetoacetate and β-hydroxy[3-14C]butyrate were used to investigate the kinetics of ketone body metabolism in rats 3h after bilateral hind-limb ischaemia and in controls, both groups being in the post-absorptive state and in a 20°C environment. Calculations were carried out as described by Heath & Barton (1973) and the following conclusions were reached. 1. In both injured and control rats, the rates of irreversible disposal (extrahepatic utilization) of β-hydroxybutyrate and acetoacetate were proportional within experimental error to their blood concentrations up to at least 0.4mm (the maximum found in these rats), implying that they were determined, via these concentrations, by the rates of production by the liver. 2. Conversion of blood β-hydroxybutyrate into blood acetoacetate took place mainly in the liver, but the reverse process occurred mainly in extrahepatic tissues. 3. The `metabolic clearance rate' (the volume of blood which, if completely cleared of substrate in unit time, would give a disposal rate equal to that in the whole animal) was calculated for β-hydroxybutyrate and acetoacetate. Comparison with the cardiac output showed that in control rats the proportion of circulating β-hydroxybutyrate extracted was lower than that of acetoacetate, clearance of which appeared almost complete. After injury both metabolic clearance rates decreased, probably because of the lower cardiac output. 4. After injury, because the average blood concentrations of ketone bodies, especially acetoacetate, were higher, the mean total rate of disposal also increased. Assuming complete oxidation, the mean contribution of ketone bodies to the whole body O2 consumption rose from 7 to 15%. PMID:4798577

The interconversion and disposal of ketone bodies in untreated and injured post-absorptive rats.

PubMed

Barton, R N

1973-11-01

[3-(14)C]Acetoacetate and beta-hydroxy[3-(14)C]butyrate were used to investigate the kinetics of ketone body metabolism in rats 3h after bilateral hind-limb ischaemia and in controls, both groups being in the post-absorptive state and in a 20 degrees C environment. Calculations were carried out as described by Heath & Barton (1973) and the following conclusions were reached. 1. In both injured and control rats, the rates of irreversible disposal (extrahepatic utilization) of beta-hydroxybutyrate and acetoacetate were proportional within experimental error to their blood concentrations up to at least 0.4mm (the maximum found in these rats), implying that they were determined, via these concentrations, by the rates of production by the liver. 2. Conversion of blood beta-hydroxybutyrate into blood acetoacetate took place mainly in the liver, but the reverse process occurred mainly in extrahepatic tissues. 3. The ;metabolic clearance rate' (the volume of blood which, if completely cleared of substrate in unit time, would give a disposal rate equal to that in the whole animal) was calculated for beta-hydroxybutyrate and acetoacetate. Comparison with the cardiac output showed that in control rats the proportion of circulating beta-hydroxybutyrate extracted was lower than that of acetoacetate, clearance of which appeared almost complete. After injury both metabolic clearance rates decreased, probably because of the lower cardiac output. 4. After injury, because the average blood concentrations of ketone bodies, especially acetoacetate, were higher, the mean total rate of disposal also increased. Assuming complete oxidation, the mean contribution of ketone bodies to the whole body O(2) consumption rose from 7 to 15%.

An observational investigation of the identity of B11244 (l-C{sub 3}H{sup +}/C{sub 3}H{sup -})

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGuire, Brett A.; Carroll, P. Brandon; Gratier, Pierre

Pety et al. have reported the detection of eight transitions of a closed-shell, linear molecule (B11244) in observations toward the Horsehead photodissociation region (PDR), which they attribute to the l-C{sub 3}H{sup +} cation. Recent high-level ab initio calculations have called this assignment into question; the anionic C{sub 3}H{sup –} molecule has been suggested as a more likely candidate. Here, we examine observations of the Horsehead PDR, Sgr B2(N), TMC-1, and IRC+10216 in the context of both l-C{sub 3}H{sup +} and C{sub 3}H{sup –}. We find no observational evidence of K{sub a} = 1 lines, which should be present were themore » carrier indeed C{sub 3}H{sup –}. Additionally, we find a strong anticorrelation between the presence of known molecular anions and B11244 in these regions. Finally, we discuss the formation and destruction chemistry of C{sub 3}H{sup –} in the context of the physical conditions in the regions. Based on these results, we conclude there is little evidence to support the claim that the carrier is C{sub 3}H{sup –}.« less

A DECISION SUPPORT TOOL (DST) FOR DISPOSAL OF ...

EPA Pesticide Factsheets

Symposium Paper AFTER A BUILDING OR WATER TREATMENT/DISTRIBUTION FACILITY HAS GONE THROUGH DECONTAMINATION ACTIVITIES FOLLOWING A CONTAMINATION EVENT WITH CHEMICAL/BIOLOGICAL WARFARE AGENTS OR TOXIC INDUSTRIAL CHEMICAL, THERE WILL BE A SIGNIFICANT AMOUNT OF RESIDUAL MATERIAL AND WASTE TO BE DISPOSED. A CONTAMINATION EVENT COULD OCCUR FROM TERRORIST ACTIVITY OR FROM A NATURAL DISASTER SUCH AS THE RECENT HURRICANE EVENTS IN THE GULF COAST WHERE MOLD AND POLLUTANTS FROM DAMAGED CHEMICAL AND INDUSTRIAL FACILITIES HAVE RESULTED IN SIGNIFICANT QUANTITIES OF CONTAMINATED MATERIALS. IT iS LIKELY THAT MUCH OF THIS MATERIAL WILL BE DISPOSED OF IN PERMITTED LANDFILLS OR HIGH TEMPERATURE THERMAL INCINERATION FACILITIES. DATA HAS BEEN COLLECTED FROM THE OPEN LITERATURE, FROM STATE AND FEDERAL REGULATORY AGENCIES, AND FROM WASTE MANAGEMENT AND WATER UTILITY INDUSTRY STAKEHOLDER GROUPS, TO DEVELOP TECHNICAL GUIDANCE FOR DISPOSAL OF THESe RESIDUES. THE INFORMATION BECOMES AVAILABLE, AND OLD INFORMATION (SUCH AS CONTACT INFORMATION FOR KEY PERSONNEL) CHANGES. THE PRiMARY AUDIENCE FOR THIS TOOL WILL BE: 1) EMERGENCY RESPONSE AUTHORITIES WHO HAVE TO DECIDE THE MOST APPROPRIATE DECONTAMINATION METHODS AND DISPOSAL OF THE RESULTING RESIDUES; 2)STATE AND LOCAL PERMITTING AGENCIES, WHO HAVE TO MAKE DECISIONS ABOUT WHICH FACILITIES WILL BE ALLOWED TO DISPOSE OF THE MATERIALS: AND 3) THE WASTE MANAGEMENT AND WATER UTILITY INDUSTRY, THAT NEEDS TO SAFELY DISPOSE OF DECONTAMINATION RESIDUE

Wastewater Disposal Wells, Fracking, and Environmental Injustice in Southern Texas.

PubMed

Johnston, Jill E; Werder, Emily; Sebastian, Daniel

2016-03-01

To investigate race and poverty in areas where oil and gas wastewater disposal wells, which are used to permanently inject wastewater from hydraulic fracturing (fracking) operations, are permitted. With location data of oil and gas disposal wells permitted between 2007 and 2014 in the Eagle Ford area, a region of intensive fracking in southern Texas, we analyzed the racial composition of residents living less than 5 kilometers from a disposal well and those farther away, adjusting for rurality and poverty, using a Poisson regression. The proportion of people of color living less than 5 kilometers from a disposal well was 1.3 times higher than was the proportion of non-Hispanic Whites. Adjusting for rurality, disposal wells were 2.04 times (95% confidence interval = 2.02, 2.06) as common in areas with 80% people of color or more than in majority White areas. Disposal wells are also disproportionately sited in high-poverty areas. Wastewater disposal wells in southern Texas are disproportionately permitted in areas with higher proportions of people of color and residents living in poverty, a pattern known as "environmental injustice."

Wastewater Disposal Wells, Fracking, and Environmental Injustice in Southern Texas

PubMed Central

Werder, Emily; Sebastian, Daniel

2016-01-01

Objectives. To investigate race and poverty in areas where oil and gas wastewater disposal wells, which are used to permanently inject wastewater from hydraulic fracturing (fracking) operations, are permitted. Methods. With location data of oil and gas disposal wells permitted between 2007 and 2014 in the Eagle Ford area, a region of intensive fracking in southern Texas, we analyzed the racial composition of residents living less than 5 kilometers from a disposal well and those farther away, adjusting for rurality and poverty, using a Poisson regression. Results. The proportion of people of color living less than 5 kilometers from a disposal well was 1.3 times higher than was the proportion of non-Hispanic Whites. Adjusting for rurality, disposal wells were 2.04 times (95% confidence interval = 2.02, 2.06) as common in areas with 80% people of color or more than in majority White areas. Disposal wells are also disproportionately sited in high-poverty areas. Conclusions. Wastewater disposal wells in southern Texas are disproportionately permitted in areas with higher proportions of people of color and residents living in poverty, a pattern known as “environmental injustice.” PMID:26794166

Unified Technical Concepts. Module 3: Rate.

ERIC Educational Resources Information Center

Technical Education Research Center, Waco, TX.

This concept module on rate is one of thirteen modules that provide a flexible, laboratory-based physics instructional package designed to meet the specialized needs of students in two-year, postsecondary technical schools. Each of the thirteen concept modules discusses a single physics concept and how it is applied to each energy system. This…

Human factors evaluation of level 2 and level 3 automated driving concepts : concepts of operation.

DOT National Transportation Integrated Search

2014-07-01

The Concepts of Operation document evaluates the functional framework of operations for Level 2 and Level 3 automated vehicle systems. This is done by defining the varying levels of automation, the operator vehicle interactions, and system components...

A high-yield, enzymatic synthesis of GDP-D-[3H]arabinose and GDP-L-[3H]fucose.

PubMed

Mengeling, B J; Turco, S J

1999-02-01

For assays involving glycosyltransferases or transporters, several GDP-sugars are either commercially unavailable or expensive. We describe an enzymatic synthesis of GDP-d-[3H]arabinosep and GDP-l-[3H]fucose that yields 66-95% nucleotide-sugar from the appropriate radiolabeled sugar in less than 30 min. The coupled reaction requires Mg2+, ATP, and GTP along with the appropriate radioactive monosaccharide, sugar-1-kinase, and pyrophosphorylase. The latter two activities are present in a cytosolic fraction of Crithidia fasciculata, which is easily grown at room temperature in simple culture medium without serum or added CO2. Addition of commercial yeast inorganic pyrophosphatase shifts the equilibrium of the pyrophosphorylase reaction toward nucleotide-sugar formation. To verify that these nucleotide-sugars are biologically active, we tested their ability to serve as substrates for glycosyltransferases. GDP-l-[3H]fucose functions as the donor substrate for recombinant human fucosyltransferase V, and GDP-d-[3H]arabinosep serves as the donor substrate for the arabinosyltransferase activities present in Leishmania major microsomes. Copyright 1999 Academic Press.