Proteomic Analyses of Cellular Events Mediating/Inhibiting Chemical-Induced Injury

DTIC Science & Technology

2009-07-21

cells in patients with sarcoidosis , an innammatory disease which is onen located in the lungs [27,28J. Cell signaling in the NRF-2 Mediated Oxidative...bronchoalveolar lavage cells in sarcoidosis . J Clin Invest 2007, 117:3576-3582. 28. Yang Y, Fujita J, Bandoh 5, Ohtsuki Y, Yamadori I, Yoshinouchi T

Determining the Existence of an Athletic Stigma on a NCAA Division II University Campus

ERIC Educational Resources Information Center

Parsons, Jennifer C. M.

2010-01-01

This project replicated a previous study by Simons, Bosworth, Fujita, and Jenson (2007) examining the existence of an athletic stigma on a university campus. For this investigation, the researcher adapted the original instrument and surveyed 252 athletes on a comprehensive Midwestern NCAA Division II university campus. The survey provided both…

40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

Code of Federal Regulations, 2012 CFR

2012-07-01

... method, or any other reliable quantitative procedure must be used for those compounds that do not absorb... any other reliable quantitative method, aqueous solutions from the generator column enter a collecting... Research of the National Bureau of Standards, 86:361-366 (1981). (7) Fujita, T. et al. “A New Substituent...

40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

Code of Federal Regulations, 2010 CFR

2010-07-01

... method, or any other reliable quantitative procedure must be used for those compounds that do not absorb... any other reliable quantitative method, aqueous solutions from the generator column enter a collecting... Research of the National Bureau of Standards, 86:361-366 (1981). (7) Fujita, T. et al. “A New Substituent...

40 CFR 799.6756 - TSCA partition coefficient (n-octanol/water), generator column method.

Code of Federal Regulations, 2011 CFR

2011-07-01

... method, or any other reliable quantitative procedure must be used for those compounds that do not absorb... any other reliable quantitative method, aqueous solutions from the generator column enter a collecting... Research of the National Bureau of Standards, 86:361-366 (1981). (7) Fujita, T. et al. “A New Substituent...

A Sub-Cloud Layer Vorticity Budget Analysis for Two Microburst-Producing Storms from Jaws Dual-Doppler Data

DTIC Science & Technology

1989-01-01

1983).p 30- 4’ ENE~q2 3 sub-categories, the macroburst and the microburst. This was to account for the varied length scales of observed downbursts...Thunderstorm. Ph.D. Dissertation, St. Louis University, 225pp. Fujita, T. T., 1985: The Downburst Microburst and Macroburst . University of Chicago Press, 122 pp

Tornado activity at SRP during 1976

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pepper, D.W.; Schubert, J.F.

1978-07-01

Tracks of three small tornadoes were confirmed on the site of the Savannah River Plant during 1976. Only minor damage to buildings and vehicles was experienced. The tornadoes were rated F1 on the Fujita-Pearson scale. Synoptic weather conditions from the National Weather Service and from the SRP seven-tower data system were recorded.

Targetable Polymer - Antiangiogenic Drug Conjugates for Systemic Breast Cancer Therapy

DTIC Science & Technology

2005-09-01

6099-103. 6 Kusaka M, Sudo K, Fujita T, Marui S, Itoh F, Ingber D, Folkman J. Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin...178: 2159 (1977). 6. S. Marui et al., Chem. Pharm. Bull, 40: 96 (1992). The U.S. Army Medical Research and Materiel Command under W81XWH-04-1-0777

Gas Source MBE Growth and Characterization of TlInGaAs/InP DH Structures for Temperature-independent Wavelength LD Application

DTIC Science & Technology

2002-01-01

Structures for Temperature-independent Wavelength LD Application Hajime Asahi, Hwe-Jae Lee, Akiko Mizobata, Kenta Konishi, Osamu Maeda and Kumiko Asami The... Yamamoto , K. Iwata, S. Gonda and K. Oe, Jpn. J. Appl. Phys. 35, L876 (1996). 3. H. Asahi, Compound Semicond. 2, 34 (1996). 4. W.S. Pelouch and L.A. Schlie...Appl. Phys. Lett. 68, 1389 (1996). 5. M. Fushida, H. Asahi, K. Yamamoto , H. Koh, K. Asami, S. Gonda and K.Oe, Jpn. J. Appl. Phys. 36, L665 (1997). 6

Independent Control of Grafting Density and Conformation of Single-Stranded DNA Brushes

DTIC Science & Technology

2007-01-02

Abstreiter G, Tornow M (2004) Langmuir 20:10086–10092. 20. Kimura-Suda H, Petrovykh DY, Tarlov MJ, Whitman LJ (2003) J Am Chem Soc 125:9014–9015. 21. Wolf...Tarlov MJ, Himpsel FJ, Whitman LJ (2006) J Am Chem Soc 128:2–3. 25. Rant U, Arinaga K, Fujiwara T, Fujita S, Tornow M, Yokoyama N, Abstreiter G (2003

The Shock and Vibration Digest. Volume 12, Number 4.

DTIC Science & Technology

1980-04-01

self -excited oscillations. a great deal of experience has been gained in applying these techniques to practical situations. This Con- INVITED...Outlet Flow Field of Axial Flow Fans Key Words: Pumps, Compressors, Self -excited vibrations, Surges H. Fujita Mechanical Engrg. Res. Lab., Hitachi, Ltd...Tsu- Investigations concerned with the stability of stationary chiura, 300 Japan, NOISE-CON 79, Machinery Noise states and the possibility of self

Structure-Activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities

DTIC Science & Technology

2010-03-09

Research, San Antonio, TX 78234, USA c Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, University of Texas at Austin...Scandinavica Supplement 548, 47–63. Hagmann, W.K., 2008. The many roles for fluorine in medicinal chemistry . Journal of Medicinal Chemistry 51, 4359–4369...Hishikawa, K., Nakaki, T., Fujita, T., 2005. Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice

The Role of a Novel Myosin Isoform in Prostate Cancer Metastasis

DTIC Science & Technology

2013-10-01

of unconventional myosin function and targeting, Annu. Rev. Cell Dev. Biol. 27 (2011) 133–155. [42] W. Kliche, S. Fujita- Becker , M. Kollmar, D.J...tissue-specific diseases (laminopathies), including Emery–Dreifuss muscular dystrophy , Dunnigan-type familial partial lipodystrophy (FPLD), and...structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies , cardiomyopathy, and partial lipodystrophy. Structure 10, 811–823

Artificial Photosynthesis: Beyond Mimicking Nature

DOE PAGES

Dau, Holger; Fujita, Etsuko; Sun, Licheng

2017-11-13

In this Editorial, Guest Editors Holger Dau, Etsuko Fujita, and Licheng Sun introduce the Special Issue of ChemSusChem on “Artificial Photosynthesis for Sustainable Fuels”. Here, they discuss the need for non-fossil based fuels, introduce both biological and artificial photosynthesis, and outline various important concepts in artificial photosynthesis, including molecular and solid-state catalysts for water oxidation and hydrogen evolution, catalytic CO 2 reduction, and photoelectrochemical systems.

Structure-Antimicrobial Activity Relationship for a New Class of Antimicrobials, Silanols, in Comparison to Alcohols and Phenols

DTIC Science & Technology

2006-08-01

equations for the antimicrobial activities and the structural properties of the silanols, the alcohols, and the phenols against four bacteria.........59 4... equations in Table 4-3. ...................................69 ix 4-6 Comparison data of PRESS and RMSPE of different classes of external compounds against...manner as shown in Equation 1-1. Hansch and Fujita derived a correlation model Equation 1-2 based on the linear free energy approach using

Artificial Photosynthesis: Beyond Mimicking Nature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dau, Holger; Fujita, Etsuko; Sun, Licheng

In this Editorial, Guest Editors Holger Dau, Etsuko Fujita, and Licheng Sun introduce the Special Issue of ChemSusChem on “Artificial Photosynthesis for Sustainable Fuels”. Here, they discuss the need for non-fossil based fuels, introduce both biological and artificial photosynthesis, and outline various important concepts in artificial photosynthesis, including molecular and solid-state catalysts for water oxidation and hydrogen evolution, catalytic CO 2 reduction, and photoelectrochemical systems.

Industrious peasants in east and west: markets, technology, and family structure in Japanese and Western European agriculture.

PubMed

De Vries, Jan

2011-01-01

Jan de Vries engages with Osamu Saito's discussion of Tokugawa Japan, in particular, his exploration of de Vries's concept of an industrious revolution for East Asia, which was published in this journal in 2010. The discussion bears on the ongoing debate over the timing and character of the Great Divergence, when advanced parts of Europe pulled ahead of Asia. de Vries argues that the constraint on the Japanese rural household to acquire and shed labour delayed the shift from supply-side industriousness to demand-motivated industriousness, which in turn meant that the Great Divergence was already in place before 1800.

AGN Feedback in Clusters of Galaxies

DTIC Science & Technology

2010-01-01

cooling non-radiatively or being heated to higher temperatures. Throughout this paper , we use the term “cooling flow” to indicate clusters with...taurus cluster [51] and M87/ Virgo [24]. Concentric ripple-like features are also seen surrounding the center of Abell 2052, but current analysis shows that...2002) Chandra Imaging of the X-ray Core of the Virgo Cluster . ApJ 579:560-570. 37. Fujita Y et al. (2002) Chandra Observations of the Disruption of the

Silanols, a New Class of Antimicrobial Agent

DTIC Science & Technology

2006-04-01

carbinols against the four bacteria was log (1/MLC) = 0.670 log P + 0.0035 ∆ν -1.836, n = 282, r = 0.96, s = 0.22. This equation and a significantly...activity relationship of antimicrobial agents by means of equations [8] based on a method proposed by Hansch and Fujita in 1964 [1]. This multiple...correlation equations between their antimicrobial activities and structural properties, log P and H-bond acidity, were created by a multiple regression

Predicate Abstraction of ANSI-C Programs using SAT

DTIC Science & Technology

2003-09-23

compositionally and automatically. In Alan J. Hu and Moshe Y. Vardi, editors, Computer-Aided Verification, CAV ’98, volume 1427, pages 319–331, Vancouver...Languages, POPL ’77, pages 238–252, 1977. [14] David W. Currie, Alan J. Hu, Sreeranga Rajan, and Masahira Fujita. Automatic formal verification of dsp...Languages and Systems (TOPLAS), 2(4):564–79, 1980. [19] A. Gupta, Z. Yang, P. Ashar , and A. Gupta. SAT-based image computation with application in

An Asymmetric Hypernova (SN 2003jd) Viewed Off-Axis, and a Link to Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Maeda, K.; et al.

2006-02-01

Authors: Keiichi Maeda, Ken Nomoto, Nozomu Tominaga (Tokyo), Paolo Mazzali, Elena Pian (Trieste), Jinsong Deng (Beijing) Type Ic supernovae, the explosions following the core collapse ofmassive stars that have previously lost their hydrogen and heliumenvelopes, are particularly interesting because of the link withlong-duration gamma-ray bursts. Although indications exist that theseexplosions are aspherical, direct evidence has still been missing.Late-time observations of SN 2003jd, a luminous hypernova, providesuch evidence. Recent Subaru and Keck spectra reveal double-peakedprofiles in the nebular lines of neutral oxygen and magnesium. Theseprofiles are different from those of known Type Ic supernovae, with orwithout a gamma-ray burst, and they can be understood if SN 2003jd wasan aspherical, axisymmetric explosion viewed from near the equatorialplane. If SN 2003jd was associated with a gamma-ray burst, we missedthe burst as it was pointing away from us.

The Regulation of Polysaccharide Specific Humoral Immune Response Against Intact Streptococcus Pneumoniae

DTIC Science & Technology

2008-06-19

Attanavanich, K . and J. F. Kearney (2004). "Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells." J Immunol 172(2): 803-11...resistance in B cells." J Immunol 157(7): 2749-53. Fujita, T., K . Inoue, et al. (1994). "Fungal metabolites. Part 11. A potent immunosuppressive activity...Girkontaite, I., K . Missy, et al. (2001). "Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses." Nat

A Selection of Test Cases for the Validation of Large-Eddy Simulations of Turbulent Flows (Quelques cas d’essai pour la validation de la simulation des gros tourbillons dans les ecoulements turbulents)

DTIC Science & Technology

1998-04-01

they approach the more useful (higher) Reynolds numbers. 8.6 SUMMARY OF COMPLEX FLOWS SQUARE DUCT CMPO00 UDOv 6.5 x 10’i E Yokosawa ei al. 164] pg...Sheets for: Chapter 8. Complex Flows 184 185 CMPOO: Flow in a square duct - Experiments Yokosawa , Fujita, Hirota, & Iwata 1. Description of the flow...These are the experiments of Yokosawa ei al (1989). Air was blown through a flow meter and a settling chamber into a square duct. Measuremsents were

1984 Ivanovo tornado outbreak: Determination of actual tornado tracks with satellite data

NASA Astrophysics Data System (ADS)

Chernokulsky, Alexander; Shikhov, Andrey

2018-07-01

The 1984 Ivanovo tornado outbreak is one of the most fatal tornado events in Europe with previously unspecified tornado track characteristics. In this paper, we used Landsat images to discover tornado-induced forest disturbances and restore actual characteristics of tornadoes during the outbreak. We defined boundaries of tornado-induced windthrows by visual comparison of satellite images and specified them with Normalized Difference Infrared Index. We confirmed the occurrence of eight tornadoes during the outbreak and determined their location, path width and length. Other tornadoes occurrence during the outbreak was discussed. Fujita-scale intensity of confirmed tornadoes was estimated based on the related literature corpus including previously omitted sources. In addition, information on tornado path lengths and widths was used to estimate minimal tornado intensity for those tornadoes that passed no settlements. In total, the Ivanovo outbreak includes 8-13 tornadoes with F-scale rating mean ranges from 1.8-2.5 and has adjusted Fujita length around 540 km, which makes the outbreak one the strongest in Europe and places it within the upper quartile of U.S. outbreaks. Characteristics of certain tornadoes within the Ivanovo outbreak are exceptional for Russia. The widest tornado path during the Ivanovo outbreak is 1740 m; the longest is from 81.5-85.9 km. With the example of the Ivanovo outbreak, we showed that existing databases on historical Russian tornadoes tend to overestimate tornado path length (for very long tornadoes) and underestimate maximum tornado path width.

Rotary-Wing Operations in a Microburst Environment.

DTIC Science & Technology

1985-04-01

weather formations and thunderstorms. The large downburst is known as a macroburst . Dr T. Fujita (5:39) of the University of Chicago describes MBWS and... macroburst wind shear: Macroburst - A large (mesoscale) sized downburst. An intense macroburst often causes widespread, tornado-like damage. Damaging...between micro and macroburst wind shear. S5-1on/s 21 rn/s T-5 Min T T+5 Min T+lO Min S T-2 MinV K 2 k’ ’-’A 1 2 4 SCALE (kan Figure 1. Five Stages of

Modeling Disordered Materials with a High Throughput ab-initio Approach

DTIC Science & Technology

2015-11-13

Catal. B: Environ. 162, 21–26 (2015). [5] S. Kurian, H . Seo, and H . Jeon, Significant Enhancement in Visible Light Absorption of TiO2 Nanotube Arrays...Ba−La−Cu−O system, Z. Phys. B Con. Mat. 64, 189–193 (1986). [7] Y. Maeno, H . Hashimoto, K. Yoshida, S. Nishizaki, T. Fujita, J. G. Bednorz, and F...epitaxial growth and characterization of InSb1−xNx on GaAs for long wavelength infrared appli- cations, J. Appl. Phys. 111 (2012). [10] H . Wang, Y. N

Reconnaissance of the chemical quality of water in western Utah, Part I: Sink Valley area, drainage basins of Skull, Rush, and Government Creek Valleys, and the Dugway Valley-Old River Bed area

USGS Publications Warehouse

Waddell, K.M.

1967-01-01

This report presents data collected during the first part of an investigation that was started in 1963 by the U.S. Geological Survey in cooperation with the Utah Geological and Mineralogical Survey. The investigation has the purpose of providing information about the chemical quality of water in western Utah that will help interested parties to evaluate the suitability of the water for various uses in a broad area of Utah where little information of this type previously has been available. The area studied includes the Sink Valley area, the drainage basins of Skull, Rush, and Government Creek Valleys, and the Dugway Valley-Old River Bed area (fig. 1). Osamu Hattori and G. L. Hewitt started the investigation, and the author completed it and prepared the report.

[Clinical pharmacy practice education in master's course of Meijo University in affiliation with medical school].

PubMed

Matsuba, Kazuhisa

2009-08-01

In 2003, Meijo University has developed a new program to train students in master's degree in the field of clinical practice. This new curriculum has three big pillars of educational goal: Problem-Based Learning (PBL), communication skill and clinical pharmacy practice training. Before exposing students to clinical training, they must learn first how to solve various patients' problems through PBL and enhance their communication skill. To provide a clinical environment, education and training, the Faculty of Pharmacy cooperated with the School of Medicine of Fujita Health University. Master's students together with other members of the healthcare team observe patient's disease state and most especially monitor pharmacotherapy. At first, students will be trained for a month at the pharmacy division and experience one week-nursing job. Next, they will be trained at the clinical divisions such as General Internal Medicine, Cardiology, Endocrinology, Gastroenterology, Respiratory Medicine, Hematology, Chemotherapy, Gastroenterological Surgery, Psychiatry, and Emergency Unit. Students rotate three-month training on four clinical divisions during one year. The head physicians of the medical department hold concurrent post as professors and share responsibility with the pharmacy faculty in training the students. To have its venue where students, faculty and physicians conduct their discussion on clinical cases, a pharmacy satellite seminar class room was set up at Fujita Health University hospital. Through this, pharmacy students and faculty had more opportunities to exchange knowledge on medicine and pharmacy. Master's students are expected to acquire professionalism, ethical knowledge and pharmaceutical care skills through the clinical pharmacy practice program.

Estimating dispersion from a tornado vortex and mesocyclone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, A.H.; Hunter, C.H.

Atmospheric dispersion modeling is required to ensure that a postulated breach in radionuclide storage containers at the Savannah River Site (SRS) from a tornado strike of Fujita-scale intensity F2 or higher will not result in an unacceptable dose to individuals. Fujita-scale tornado descriptions are included in Appendix A of this report. Dispersion models previously used at SRS for estimating dispersion following a tornado strike were developed by D.W. Pepper in 1975 (DP-1387, Dispersion of Small Particles) and H.R. Haynes and D.W. Taylor in 1983 (DPST-82-982, Estimating Doses from Tornado Winds). Research conducted in 1983 on the formation and evolution ofmore » tornadic thunderstorms has lead to a more complete understanding of the tornado vortex and associated persistent updraft and downdraft regions within the parent thunderstorm. To ensure that appropriate, contemporary methods are used for safety analysis, the Pepper model and the Haynes and Taylor model were evaluated with respect to current knowledge of circulations within tornadic thunderstorms. Pepper`s model is complex numerically but contains most of the desired physical parameterizations. Haynes and Taylor`s model is used with the Puff-Plume model (an emergency response model on the Weather INformation and Display System at SRS) and has provisions for radionuclide deposition and rainout. Haynes and Taylor assumed heavy rain following the tornado for a period of ten minutes, followed by a lighter rain for another ten minutes, then no rain for the period when the material is transported to 100 km downwind. However, neither model incorporates the effects of a nearby thunderstorm downdraft.« less

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.

PubMed

Fujimoto, Tatsuhiko; Kunitomo, Jun; Tomata, Yoshihide; Nishiyama, Keiji; Nakashima, Masato; Hirozane, Mariko; Yoshikubo, Shin-Ichi; Hirai, Keisuke; Marui, Shogo

2011-11-01

During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett σ(p) and Hansch-Fujita π value as aromatic substituent constants. The attempts led to the discovery of compound 1m, possessing good in vitro potency with over 100-fold selectivity against OX1R, good metabolic stability in human and rat liver microsome, good oral bioavailability in rats, and in vivo antagonistic activity in rats by oral administration. Copyright © 2011 Elsevier Ltd. All rights reserved.

The computational analysis and modelling of substitution effects on hydrolysis of formanilides in acidic aqueous solutions

NASA Astrophysics Data System (ADS)

Lukeš, Vladimír; Škorňa, Peter; Michalík, Martin; Klein, Erik

2017-11-01

Various para, meta and ortho substituted formanilides have been theoretically studied. For trans and cis-isomers of non-substituted formanilide, the calculated B3LYP vibration normal modes were analyzed. Substituent effect on the selected normal modes was described and the comparison with the available experimental data is presented. The calculated B3LYP proton affinities were correlated with Hammett constants, Fujita-Nishioka equation and the rate constants of the hydrolysis in 1 M HCl. Found linear dependences allow predictions of dissociation constants (pKBH+) and hydrolysis rate constants. Obtained results indicate that protonation of amide group may represent the rate determining step of acid catalyzed hydrolysis.

An observational analysis of a derecho in South China

NASA Astrophysics Data System (ADS)

Xia, Rudi; Wang, Donghai; Sun, Jianhua; Wang, Gaili; Xia, Guancong

2012-12-01

Derechos occur frequently in Europe and the United States, but reports of derechos in China are scarce. In this paper, radar, satellite, and surface observation data are used to analyze a derecho event in South China on 17 April 2011. A derecho-producing mesoscale convective system formed in an environment with medium convective available energy, strong vertical wind shear, and a dry layer in the middle troposphere, and progressed southward in tandem with a front and a surface wind convergence line. The windstorm can be divided into two stages according to differences in the characteristics of the radar echo and the causes of the gale. One stage was a supercell stage, in which the sinking rear inflow of a high-precipitation supercell with a bow-shaped radar echo induced a Fujita F0 class gale. The other stage was a non-supercell stage (the echo was sequentially kidney-shaped, foot-shaped, and an ordinary single cell), in which downbursts induced a gale in Fujita F1 class. This derecho event had many similarities with derechos observed in western countries. For example, the windstorm was perpendicular to the mean flow, the gale was located in the bulging portion of the bow echo, and the derecho moved southward along with the surface front. Some differences were observed as well. The synoptic-scale forcing was weak in the absence of an advancing high-amplitude midlevel trough and an accompanying strong surface cyclone; however, the vertical wind shear was very strong, a characteristic typical of derechos associated with strong synoptic-scale forcing. Extremely high values of convective available potential energy and downdraft convective available potential energy have previously been considered necessary to the formation of weak-forcing archetype and hybrid derechos; however, these values were much less than 2000 J during this derecho event.

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.

PubMed

Ichinose, H; Ohye, T; Matsuda, Y; Hori, T; Blau, N; Burlina, A; Rouse, B; Matalon, R; Fujita, K; Nagatsu, T

1995-04-28

GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Matsumoto, S., Fujita, K., and Nagatsu, T. (1992) Biochem. Biophys. Res. Commun. 187, 359-365). Furthermore, very recently, we found that the GTP cyclohydrolase I gene is causative for hereditary progressive dystonia with marked diurnal fluctuation, also known as DOPA-responsive dystonia (Ichinose, H., Ohye, T., Takahashi, E., Seki, N., Hori, T., Segawa, M., Nomura, Y., Endo, K., Tanaka, H., Tsuji, S., Fujita, K., and Nagatsu, T. (1994) Nature Genetics 8, 236-242). To clarify the mechanisms that regulate transcription of the GTP cyclohydrolase I gene and to generate multiple species of mRNA, we isolated genomic DNA clones for the human and mouse GTP cyclohydrolase I genes. Structural analysis of the isolated clones revealed that the GTP cyclohydrolase I gene is encoded by a single copy gene and is composed of six exons spanning approximately 30 kilobases. We sequenced all exon/intron boundaries of the human and mouse genes. Structural analysis also demonstrated that the heterogeneity of GTP cyclohydrolase I mRNA is caused by an alternative usage of the splicing acceptor site at the sixth exon. The transcription start site of the mouse GTP cyclohydrolase I gene and the 5'-flanking sequences of the mouse and human genes were determined. We performed regional mapping of the mouse gene by fluorescence in situ hybridization, and the mouse GTP cyclohydrolase I gene was assigned to region C2-3 of mouse chromosome 14. We identified missense mutations in patients with GTP cyclohydrolase I deficiency and expressed mutated enzymes in Escherichia coli to confirm alterations in the enzyme activity.

[Proposal for graduate school education in the future: from the viewpoint of the Department of clinical Laboratory in a university hospital].

PubMed

Ishii, Junichi

2009-08-01

Fujita Health University Hospital, located in Toyoake, is a large teaching hospital with 1,505 beds. The Department of Clinical Laboratory in our hospital, in which 136 medical technologists work, is one of the largest clinical laboratories in Japan. Medical technologists in our hospital are required not only to perform accurate laboratory examinations, but also to contribute to the medical care team. In addition, they must educate students and trainee medical technologists. Furthermore, they conduct research to develop and evaluate new laboratory methods. Thus, we hope that education in graduate schools of medical technology (Master's course), along with promoting the specialty of laboratory techniques, will develop students' clinical skills to examine patients and research skills to conduct studies.

Polarization Processing Techniques Study

DTIC Science & Technology

1979-11-01

Scattere,’" IEEE Trans on AES, Vol 3, pp 171-178, 1967. - m ---: - .Jmm5 a mi •i• . Q AMODEL FOR THE SLVVLA TION OF THE SPECTRA L AND GEORGE A...Mr. Masaaki (Tom) Fujita FEB it so Dr. George Ioannidis Dr. i’han Levan Dr. Jeffery Bell Mr. Charles Lucas AMOED M PBM EAS. ISTRIUTKJN INUMIMiD I c.L...FinalUF STtY’ n " -- - p~ar 7S8 Var 79.L, Mr. t lber ~.i 4MJI George /7fioannz~ff1,;- WS"’’ wx.~~ ~ ~ ~ I.ler ~er30602-7F-C-01.39IF Dr. J~ni Ha-ezE Dr. Jeff

Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea Syndrome.

PubMed

Bakan, Ebubekir; Fidan, Vural; Alp, Hamit Hakan; Baygutalp, Nurcan Kilic; Cokluk, Erdem

2015-07-01

Snoring is a social hindrance problem and it can cause life threatening problems. Because of this it must be taken seriously and must be treated. Although there are many ways for treating this problem, still uvulopalatopharngoplasty (UPPP) which is an accepted classical method maintains its importance. Antioxidant status in patients with snoring have been investigated. All studies investigated the effect of CPAP treatment on the level of antioxidant agents. In this study we have examined the effect of UPPP on the level of antioxidant agents in patients with snoring.

Internet-based survey on medical manga in Japan.

PubMed

Kishi, Yukiko; Matsumura, Tomoko; Murishige, Naoko; Kodama, Yuko; Hatanaka, Nobuyo; Takita, Morihito; Sakamoto, Kenjiro; Hamaki, Tamae; Kusumi, Eiji; Kobayashi, Kazuhiko; Yuji, Koichiro; Narimatsu, Hiroto; Kami, Masahiro

2011-10-01

The more manga (Japanese graphic novels) communicate medical information, the more people are likely to be influenced by manga. We investigated through an Internet search using Google the characteristics of medical manga published in Japan, defined as those in which the main character is a medical professional and that occur in a medical setting. As of December 2008, 173 medical manga had been published. For a period of time after the first medical manga by Osamu Tezuka in 1970, the number of publications maintained a steady level, but increased rapidly in the mid 1980s. The professions of the protagonist were 134 doctors, 19 nurses, 3 dentists, 3 medical students, and 1 nursing student. Although the main character was mostly a doctor, manga featuring paramedical professionals have increased since 1990s. Medical manga may be a powerful tool for increasing the awareness of the public regarding medicine.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waterman, Michael R.

Our understanding of the classification, function, mechanism, and structure of the enzymes which incorporate atoms of oxygen from atmospheric molecular oxygen during catalysis is based on the thoughtful and technically challenging experiments of two giants in the field of Biochemistry, Howard Mason and Osamu Hayaishi. This volume celebrates the 50th anniversary of the discovery and characterization of these 'oxygenase' enzymes and provides a broad view of how far this area of research has advanced. Professor Hayaishi describes herein his perspective on the background and major discoveries which led to the development of this field. Regrettably Howard Mason passed away atmore » age 88 in 2003. I am indeed fortunate to have been a Ph.D. student with Howard and to have the opportunity to briefly review his role in the development of this field for this special commemorative issue of BBRC.« less

Prevention of child injuries during tornadoes: cases from the 2011 tornado outbreak in Alabama.

PubMed

Campbell, Christine M; Baker, Mark D; Monroe, Kathy W

2012-12-01

Tornadoes and violent weather pose a hazard to children, yet little is known about the use of personal protective devices during storms. An outbreak of tornadoes on April 27, 2011, resulted in the deaths of 23 children in Alabama. Records from 60 patients seen in a pediatric emergency department for tornado-related injuries were reviewed to identify the use of injury prevention devices. Three children directly exposed to a violent tornado (Enhanced Fujita Scale 4) were using safety equipment, specifically, a helmet and infant car seats. These 3 children sustained only minor injuries. Personal protective devices may have played a role in preventing child injuries from tornadoes. To our knowledge, this is the first report in the medical literature on helmet and infant car seat use as child protective devices during tornadoes.

Close-up view of 20 March 1976 tornadoes - Sinking cloud tops to suction vortices

NASA Technical Reports Server (NTRS)

Fujita, T. T.; Forbes, G. S.; Umenhofer, T. A.

1976-01-01

The article describes an airborne mission using a Learjet to secure direct data on a family of tornadoes spawned by a rotating thunderstorm in the Missouri-Illinois-Indiana area in March 1976 following an unusually warm February. Weakening of the tornado following increased cloud-scale vertical motion, predicted by a model constructed by Fujita (1972), was confirmed. The aircraft inspected overshooting cloud tops, examined subsidence (holes and depressions) in anvil tops it overflew, and surveyed footprints left by the tornadoes and tornado-blown litter on the ground traversed by the disturbances. Subsidence of cloud tops in advance of violent tornadoes below was confirmed. Isolated and multiple suction vortices left their characteristic ground marks; three scales of motion: tornado cyclone, tornado, and suction vortex, are evidenced by the ground truth.

Why some Jehovah's Witnesses accept blood and conscientiously reject official Watchtower Society blood policy

PubMed Central

Elder, L.

2000-01-01

In their responses to Dr Osamu Muramoto (hereafter Muramoto) Watchtower Society (hereafter WTS) spokesmen David Malyon and Donald Ridley (hereafter Malyon and Ridley),1–3 deny many of the criticisms levelled against the WTS by Muramoto.4–6 In this paper I argue as a Jehovah's Witness (hereafter JW) and on behalf of the members of AJWRB that there is no biblical basis for the WTS's partial ban on blood and that this dissenting theological view should be made clear to all JW patients who reject blood on religious grounds. Such patients should be guaranteed confidentiality should they accept whole blood or components that are banned by the WTS. I argue against Malyon's and Ridley's claim that WTS policy allows freedom of conscience to individual JWs and that it is non-coercive and non-punitive in dealing with conscientious dissent and I challenge the notion that there is monolithic support of the WTS blood policy among those who identify themselves as JWs and carry the WTS "advance directive". Key Words: Blood transfusion • Jehovah's Witnesses • Watchtower • autonomy PMID:11055042

A point hailfall classification based on hailpad measurements: The ANELFA scale

NASA Astrophysics Data System (ADS)

Dessens, J.; Berthet, C.; Sanchez, J. L.

2007-02-01

The ANELFA scale for hailfall intensity is proposed on the model of the 6-class Fujita scale for tornadoes. It is based on more than three thousand point hailfalls measured by hailpads over a 16-year period in France. The class number of a hailfall is determined by the integer value of the largest measured hailstone diameter in cm, or by equivalence with current objects: A0 to A5 for pea, grape, pigeon's egg, walnut, hen's egg, orange. The class number is followed by a plus or minus sign if the ground is significantly more or less than half-covered by hailstones respectively. When the scale is applied to the ANELFA data, a log-normal distribution is found for the class distribution, allowing the frequency determination of the upper class ever observed until now at the hailpad stations.

On flows of viscoelastic fluids under threshold-slip boundary conditions

NASA Astrophysics Data System (ADS)

Baranovskii, E. S.

2018-03-01

We investigate a boundary-value problem for the steady isothermal flow of an incompressible viscoelastic fluid of Oldroyd type in a 3D bounded domain with impermeable walls. We use the Fujita threshold-slip boundary condition. This condition states that the fluid can slip along a solid surface when the shear stresses reach a certain critical value; otherwise the slipping velocity is zero. Assuming that the flow domain is not rotationally symmetric, we prove an existence theorem for the corresponding slip problem in the framework of weak solutions. The proof uses methods for solving variational inequalities with pseudo-monotone operators and convex functionals, the method of introduction of auxiliary viscosity, as well as a passage-to-limit procedure based on energy estimates of approximate solutions, Korn’s inequality, and compactness arguments. Also, some properties and estimates of weak solutions are established.

Comparison of Methods for Characterizing Nonideal Solute Self-Association by Sedimentation Equilibrium

PubMed Central

Scott, David J.; Winzor, Donald J.

2009-01-01

Abstract We have examined in detail analytical solutions of expressions for sedimentation equilibrium in the analytical ultracentrifuge to describe self-association under nonideal conditions. We find that those containing the radial dependence of total solute concentration that incorporate the Adams-Fujita assumption for composition-dependence of activity coefficients reveal potential shortcomings for characterizing such systems. Similar deficiencies are shown in the use of the NONLIN software incorporating the same assumption about the interrelationship between activity coefficients for monomer and polymer species. These difficulties can be overcome by iterative analyses incorporating expressions for the composition-dependence of activity coefficients predicted by excluded volume considerations. A recommendation is therefore made for the replacement of current software packages by programs that incorporate rigorous statistical-mechanical allowance for thermodynamic nonideality in sedimentation equilibrium distributions reflecting solute self-association. PMID:19651047

Multi-millennial-scale climate variability in Antarctica during the past seven glacial periods

NASA Astrophysics Data System (ADS)

Kawamura, K.

2009-12-01

Climate variability on 1,000- to 10,000 -year timescales and associated interhemispheric seesaw during the last glacial period have been documented in a variety of paleoclimatic records. However, the frequency, magnitude, cause and prerequisites for the older glacial periods are still uncertain. We here present a new 720,000-year ice core record from Dome Fuji, East Antarctica. The agreement between the Dome Fuji and Dome C isotopic temperature records indicates homogeneous climate variability across the East Antarctic plateau throughout the past 720 kyr. By combining the two temperature proxy records, we identified persistent multi-millennial-scale Antarctic events over the past seven glacial periods. With a fully coupled atmosphere-ocean general circulation model, it is suggested that the prerequisite for the bipolar seesaw is the combination of a cold background climate and freshwater input into the northern North Atlantic. With our identification criteria, the mean repetition period of the large Antarctic events increased from 6 kyr in the older three glacial periods to 8 kyr in the younger four glacial periods. Low frequency variations (repetition period of >10 kyr) occur in the early parts of the last four glacial periods (i.e. after Mid-Brunhes climatic shift), suggesting a role of insolation forcing on the large bipolar events in the recent glacial periods. Dome Fuji Ice Core Project members (listed in alphabetical order): Ayako Abe-Ouchi, Yutaka Ageta, Shuji Aoki, Nobuhiko Azuma, Yoshiyuki Fujii, Koji Fujita, Shuji Fujita, Kotaro Fukui, Teruo Furukawa, Atsushi Furusaki, Kumiko Goto-Azuma, Ralf Greve, Motohiro Hirabayashi, Takeo Hondoh, Akira Hori, Shinichiro Horikawa, Kazuho Horiuchi, Makoto Igarashi, Yoshinori Iizuka, Takao Kameda, Kokichi Kamiyama, Hiroshi Kanda, Kenji Kawamura, Mika Kohno, Takayuki Kuramoto, Yuki Matsushi, Morihiro Miyahara, Takayuki Miyake, Atsushi Miyamoto, Hideaki Motoyama, Yasuo Nagashima, Yoshiki Nakayama, Takakiyo Nakazawa, Fumio

Guppies (Poecilia reticulata) introducing an alien parasite, Camallanus cotti (Nematoda: Camallanidae) to Africa, the first report.

PubMed

Tavakol, Sareh; Halajian, Ali; Smit, Willem J; Hoffman, Andre; Luus-Powell, Wilmien J

2017-12-01

Introduced alien fish species and their associated parasites may result in a serious threat to indigenous biodiversity. Furthermore, this may have negative impacts on cultured fish as well as on native parasitic fauna. In the present study, the invasive Asian nematode, Camallanus cotti Fujita, 1927 (Nematoda: Camallanidae), is reported from the guppy (Poecilia reticulata) for the first time in Africa. This parasite is assumed to be introduced into Africa along with the introduction of exotic poeciliid fishes, which are known to be the most common hosts of C. cotti in ornamental fish industry worldwide.The presence of this parasite in both aquarium-cultured fish as well as fish from natural waterbodies is evidence of the introduction of the alien organisms due to insufficient prophylactic veterinary control during transfer of non-native hosts between countries and the spread of them by the anthropogenic introduction to natural systems.

Sparse QSAR modelling methods for therapeutic and regenerative medicine

NASA Astrophysics Data System (ADS)

Winkler, David A.

2018-02-01

The quantitative structure-activity relationships method was popularized by Hansch and Fujita over 50 years ago. The usefulness of the method for drug design and development has been shown in the intervening years. As it was developed initially to elucidate which molecular properties modulated the relative potency of putative agrochemicals, and at a time when computing resources were scarce, there is much scope for applying modern mathematical methods to improve the QSAR method and to extending the general concept to the discovery and optimization of bioactive molecules and materials more broadly. I describe research over the past two decades where we have rebuilt the unit operations of the QSAR method using improved mathematical techniques, and have applied this valuable platform technology to new important areas of research and industry such as nanoscience, omics technologies, advanced materials, and regenerative medicine. This paper was presented as the 2017 ACS Herman Skolnik lecture.

Are the islets of Langerhans neuro-paraneuronal control centers of the exocrine pancreas?

PubMed

Radke, R; Stach, W

1986-10-01

The authors investigate whether the islets of Langerhans can actually be regarded as "neuro-paraneuronal control centers of the exocrine pancreas" as was first suggested by Fujita and Kobayashi (1979). The question is discussed on the basis of the authors' electron microscopic findings regarding pancreatic innervation before and after truncular vagotomy. The results do not seem to support the above hypothesis which advocates that the intrainsular axons are principally engaged in the release of their transmitters into the capillaries in order to regulate, via the insuloacinar portal vessels, the exocrine function of the pancreas. On the contrary, the present data draw attention to the unambiguous assignation of intrainsular axons to endocrine cells, a point of question in line with several findings published in the literature including papers by the first supporters of this hypothesis. No change was observed in the innervation pattern of the effector cells after vagotomy.

Gauge Physics of Spin Hall Effect

PubMed Central

Tan, Seng Ghee; Jalil, Mansoor B. A.; Ho, Cong Son; Siu, Zhuobin; Murakami, Shuichi

2015-01-01

Spin Hall effect (SHE) has been discussed in the context of Kubo formulation, geometric physics, spin orbit force, and numerous semi-classical treatments. It can be confusing if the different pictures have partial or overlapping claims of contribution to the SHE. In this article, we present a gauge-theoretic, time-momentum elucidation, which provides a general SHE equation of motion, that unifies under one theoretical framework, all contributions of SHE conductivity due to the kinetic, the spin orbit force (Yang-Mills), and the geometric (Murakami-Fujita) effects. Our work puts right an ambiguity surrounding previously partial treatments involving the Kubo, semiclassical, Berry curvatures, or the spin orbit force. Our full treatment shows the Rashba 2DEG SHE conductivity to be instead of −, and Rashba heavy hole instead of −. This renewed treatment suggests a need to re-derive and re-calculate previously studied SHE conductivity. PMID:26689260

Concentric waves and short-period oscillations observed in the ionosphere after the 2013 Moore EF5 tornado

NASA Astrophysics Data System (ADS)

Nishioka, Michi; Tsugawa, Takuya; Kubota, Minoru; Ishii, Mamoru

2013-11-01

We detected clear concentric waves and short-period oscillations in the ionosphere after an Enhanced Fujita scale (EF)5 tornado hit Moore, Oklahoma, U.S., on 20 May 2013 using dense wide-coverage ionospheric total electron content (TEC) observations in North America. These concentric waves were nondispersive, with a horizontal wavelength of ~120 km and a period of ~13 min. They were observed for more than 7 h throughout North America. TEC oscillations with a period of ~4 min were also observed to the south of Moore for more than 8 h. A comparison between the TEC observations and infrared cloud image from the GOES satellite indicates that the concentric waves and short-period oscillations are caused by supercell-induced atmospheric gravity waves and acoustic resonances, respectively. This observational result provides the first clear evidence of a severe meteorological event causing atmospheric waves propagating upward in the upper atmosphere and reaching the ionosphere.

The History of Sleep Surgery.

PubMed

Yaremchuk, Kathleen; Garcia-Rodriguez, Laura

2017-01-01

Snoring and the subsequent diagnosis of obstructive sleep apnea (OSA) was a life-threatening medical condition with no available treatment until the late 20th century. An early description of OSA was provided by Charles Dickens in his 1836 novel Pickwick Papers with the description of a "fat boy" who was thought to be lazy and always falling asleep but likely displayed hypersomnolence from OSA. It was not until 1976 that Ikematsu first described uvulopalatopharyngoplasty (UPPP) as an alternative surgical treatment of "snoring," with a reported cure rate of 81%. The only other surgical procedure for OSA was permanent tracheostomy, but patients suffered from social stigma from the visible stoma with skin flaps and complications such as tracheal granulomas and tracheitis. UPPP was introduced in the USA as an alternative to permanent tracheostomy by Fujita in 1981. Since then, multiple surgical approaches and combinations of approaches have surfaced, with variable success rates. © 2017 S. Karger AG, Basel.

What influences climate and glacier change in southwestern China?

NASA Astrophysics Data System (ADS)

Yasunari, Teppei J.

2011-12-01

The subject of climate change in the Tibetan Plateau (TP) and Himalayas has taken on increasing importance because of the availability of water resources from their mountain glaciers (Immerzeel et al 2010). Many of the glaciers over these regions have been retreating, while some are advancing and stable (Yao et al 2004, Scherler et al 2011). Other studies report that some glaciers in the Himalayas show acceleration of their shrinkage (e.g., Fujita and Nuimura 2011). However, the causes of glacier melting are still difficult to grasp because of the complexity of climatic change and its influence on glacier issues. Despite this, it is vital that we pursue further study to enable future predictions of glacier changes. The paper entitled 'Climate and glacier change in southwestern China during the past several decades' by Li et al (2011) provided carefully analyzed, quality controlled, long-term data on atmospheric temperature and precipitation during the period 1961-2008. The data were obtained from 111 Chinese stations. The researchers performed systematic analyses of temperature and precipitation over the whole southwestern Chinese domain. They discussed those changes in terms of other meteorological components such as atmospheric circulation patterns, radiation and altitude difference, and then showed how these factors could contribute to climate and glacier changes in the region. Air temperature and precipitation are strongly associated with glacier mass balance because of heat balance and the addition of mass when it snows. Temperature warming trends over many places in southwestern China were unequivocally dominant in all seasons and at higher altitudes. This indicates that the heat contribution to the glaciers has been increasing. On the other hand, precipitation has a wider variability in time and space. It is more difficult to clearly understand the effect of precipitation on the climate and glacier melting characteristics in the whole of southwestern China

Metal Insulator transition in Vanadium Dioxide

NASA Astrophysics Data System (ADS)

Jovaini, Azita; Fujita, Shigeji; Suzuki, Akira; Godoy, Salvador

2012-02-01

MAR12-2011-000262 Abstract Submitted for the MAR12 Meeting of The American Physical Society Sorting Category: 03.9 (T) On the metal-insulator-transition in vanadium dioxide AZITA JOVAINI, SHIGEJI FUJITA, University at Buffalo, SALVADOR GODOY, UNAM, AKIRA SUZUKI, Tokyo University of Science --- Vanadium dioxide (VO2) undergoes a metal-insulator transition (MIT) at 340 K with the structural change from tetragonal to monoclinic crystal. The conductivity _/ drops at MIT by four orders of magnitude. The low temperature monoclinic phase is known to have a lower ground-state energy. The existence of the k-vector k is prerequisite for the conduction since the k appears in the semiclassical equation of motion for the conduction electron (wave packet). The tetragonal (VO2)3 unit is periodic along the crystal's x-, y-, and z-axes, and hence there is a three-dimensional k-vector. There is a one-dimensional k for a monoclinic crystal. We believe this difference in the dimensionality of the k-vector is the cause of the conductivity drop. Prefer Oral Session X Prefer .

Development of quantitative structure-activity relationships and its application in rational drug design.

PubMed

Yang, Guang-Fu; Huang, Xiaoqin

2006-01-01

Over forty years have elapsed since Hansch and Fujita published their pioneering work of quantitative structure-activity relationships (QSAR). Following the introduction of Comparative Molecular Field Analysis (CoMFA) by Cramer in 1998, other three-dimensional QSAR methods have been developed. Currently, combination of classical QSAR and other computational techniques at three-dimensional level is of greatest interest and generally used in the process of modern drug discovery and design. During the last several decades, a number of different mythologies incorporating a range of molecular descriptors and different statistical regression ways have been proposed and successfully applied in developing of new drugs, thus QSAR method has been proven to be indispensable in not only the reliable prediction of specific properties of new compounds, but also the help to elucidate the possible molecular mechanism of the receptor-ligand interactions. Here, we review the recent developments in QSAR and their applications in rational drug design, focusing on the reasonable selection of novel molecular descriptors and the construction of predictive QSAR models by the help of advanced computational techniques.

Individual relocation decisions after tornadoes: a multi-level analysis.

PubMed

Cong, Zhen; Nejat, Ali; Liang, Daan; Pei, Yaolin; Javid, Roxana J

2018-04-01

This study examines how multi-level factors affected individuals' relocation decisions after EF4 and EF5 (Enhanced Fujita Tornado Intensity Scale) tornadoes struck the United States in 2013. A telephone survey was conducted with 536 respondents, including oversampled older adults, one year after these two disaster events. Respondents' addresses were used to associate individual information with block group-level variables recorded by the American Community Survey. Logistic regression revealed that residential damage and homeownership are important predictors of relocation. There was also significant interaction between these two variables, indicating less difference between homeowners and renters at higher damage levels. Homeownership diminished the likelihood of relocation among younger respondents. Random effects logistic regression found that the percentage of homeownership and of higher income households in the community buffered the effect of damage on relocation; the percentage of older adults reduced the likelihood of this group relocating. The findings are assessed from the standpoint of age difference, policy implications, and social capital and vulnerability. © 2018 The Author(s). Disasters © Overseas Development Institute, 2018.

Swirl ratio effects on tornado-like vortices

NASA Astrophysics Data System (ADS)

Hashemi-Tari, Pooyan; Gurka, Roi; Hangen, Horia

2007-11-01

The effect of swirl ratio on the flow field for a tornado-like vortex simulator (TVS) is investigated. Different swirl ratios are obtained by changing the geometry and tangential velocity which determine the vortex evolution. Flow visualizations, surface pressure and Particle Image Velocimetry (PIV) measurements are performed in a small TVS for swirl ratios S between 0 and 1. The PIV data was acquired for two orthogonal planes: normal and parallel to the solid boundary at several height locations. The ratio between the angular momentum and the radial momentum which characterize the swirl ratio is investigated. Statistical analysis to the turbulent field is performed by mean and rms profiles of the velocity, stresses and vorticity are presented. A Proper Orthogonal Decomposition (POD) is performed on the vorticity field. The results are used to: (i) provide a relation between these 3 sets of qualitative and quantitative measurements and the swirl ratio in an attempt to relate the fluid dynamics parameters to the forensic, Fujita scale, and (ii) understand the spatio-temporal distribution of the most energetic POD modes in a tornado-like vortex.

Spermiogenesis and Taxonomical Values of Sperm Ultrastructures in Male Crassostrea ariakensis (Fujita & Wakiya, 1929) (Pteroirmorphia: Ostreidae) in the Estuary of the Seomjin River, Korea

PubMed Central

Son, Pal Won; Chung, Jae Seung; Kim, Jin Hee; Kim, Sung Han; Chung, Ee-Yung

2014-01-01

Characteristics of the developmental stages of spermatids during spermiogenesis and phylogenetic classicfication of the species using sperm ultrastructures in male Crassostrea ariakensis were investigated by transmission electron microscope observations. The morphology of the spermatozoon of this species has a primitive type and is similar to those of Ostreidae. Ultrastructures of mature sperms are composed of broad, modified cap-shaped acrosomal vesicle and an axial rod in subacrosomal materials on an oval nucleus, four spherical mitochondria in the sperm midpiece, and satellite fibres which appear near the distal centriole. The axoneme of the sperm tail shows a 9+2 structure. Accordingly, the ultrastructural characteristics of mature sperm of C. ariakensis resemble to those of other investigated ostreids in Ostreidae in the subclass Pteriomorphia. In this study, particularly, two transverse bands (stripes) appear at the anterior region of the acrosomal vesicle of this species, unlike two or three transverse bands (stripes) in C. gigas. It is assumed that differences in this acrosomal substructure are associated with the inability of fertilization between the genus Crassostrea and other genus species in Ostreidae. Therefore, we can use sperm ultrastructures and morphologies in the resolution of taxonomic relationships within the Ostreidae in the subclass Pteriomorphia. These spermatozoa, which contain several ultrastructures such as acrosomal vesicle, an axial rod in the sperm head part and four mitochondria and satellite fibres in the sperm midpiece, belong to the family Ostreidae in the subclass Pteriomorphia. PMID:25949188

Simulation of hydrothermal recoveries by adopting symbiotic urban scenario in the Japanese megalopolis

NASA Astrophysics Data System (ADS)

Nakayama, T.; Fujita, T.; Hashimoto, S.; Hamano, H.

2008-05-01

The heat island phenomenon in summer has become a serious environmental problem with the expansion of cities and industrial areas in Japan. The present research evaluated the positive cooling effect of new material pavement (water-holding blocks) in comparison with the passive cooling effect of lawn. We coupled the process- based NIES Integrated Catchment-based Eco-hydrology (NICE) model (Nakayama, 2008; Nakayama and Watanabe, 2004, 2006, 2007; Nakayama et al., 2006, 2007) to an urban canopy model (Nakayama and Fujita, 2008) and the Regional Atmospheric Modeling System (RAMS) in order to simulate the effect of this newly symbiotic pavement on the hydrologic budget and the regional climate at the Kawasaki eco-town in Japan, with a grid spacing of 200 m. The model simulated the water and heat budgets in various types of natural and artificial pavements (covered by lawn, concrete, steel plate, synthetic rubber sheet, infiltration and water-holding blocks), and to evaluate the role of water-holding blocks in promoting evaporation and cooling to counter the heat island phenomenon (2 degrees lower than that at the lawn), by comparing with the simplified empirical model. The heat budget analysis of observation data showed that the latent heat flux at the water-holding pavement has a strong impact on the cooling temperature, which could be reproduced well by the simulation. Because the water temperature in an aquifer is almost constant throughout the year, it is estimated that the use of groundwater as a heat sink would be very effective for tackling the urban heat island phenomenon, particularly during the summer (Ministry of Environment, 2003). We evaluated the relationship between the effect of groundwater use to ameliorate the heat island phenomenon and the effect of infiltration on the water cycle in the catchment. The procedure to integrate the model simulation with political scenario for the effective selection and use of ecosystem service sites in this study would

EDITORIAL: Integrated assessments of environmental change on the Tibetan Plateau Integrated assessments of environmental change on the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Sheng, Yongwei; Yao, Tandong

2009-12-01

The Tibetan Plateau is one of the Earth's most sensitive regions in responding to climate change due to its extremely high altitude and the presence of permafrost and glaciers. The cryosphere, biosphere and hydrosphere of the plateau have been undergoing significant changes. Due to the low human population density, environmental changes on the plateau are largely driven by natural processes. Thus, the plateau provides a unique and comprehensive site for global change studies. This focus issue on Climate Change on the Tibetan Plateau aims to address both paleo and recent environmental changes across the plateau to facilitate our understanding of this remote and under-studied area. We invited a wide spectrum of contributions to address climate change, permafrost degradation, glacier/snow/ice dynamics, lake dynamics, land- cover/land-use changes, and their interactions on the plateau. Collectively, the diverse contributions in this special issue are expected to present the recent advancement of the above topics and beyond. See the PDF for the full text of the editorial. Focus on Climate Change on the Tibetan Plateau Contents Does a weekend effect in diurnal temperature range exist in the eastern and central Tibetan Plateau? Qinglong You, Shichang Kang, Wolfgang-Albert Flügel, Arturo Sanchez-Lorenzo, Yuping Yan, Yanwei Xu and Jie Huang Diurnal variations of summertime precipitation over the Tibetan Plateau in relation to orographically-induced regional circulations Xiaodong Liu, Aijuan Bai and Changhai Liu Lake-level fluctuations since the Last Glaciation in Selin Co (lake), Central Tibet, investigated using optically stimulated luminescence dating of beach ridges Dewen Li, Yingkui Li, Baoqi Ma, Guocheng Dong, Liqiang Wang and Junxiang Zhao Recent changes in Imja Glacial Lake and its damming moraine in the Nepal Himalaya revealed by in situ surveys and multi-temporal ASTER imagery Koji Fujita, Akiko Sakai, Takayuki Nuimura, Satoru Yamaguchi and Rishi R Sharma Changes

Coastal submergence at Ukishima-ga-hara adjacent to the Suruga Trough (eastern Nankai Trough), central Japan, inferred from diatoms and plant macrofossils

NASA Astrophysics Data System (ADS)

Sawai, Y.; Momohara, A.

2017-12-01

Five episodic submergence events during the past 3500 years were recognized at the Ukishima-ga-hara lowland, northern coast of Suruga Trough (eastern Nankai Trough). Coastal submergence in this region was originally reported by Osamu Fujiwara and his colleagues (e.g., Fujiwara et al., 2016) based mainly on changes in lithostratigraphy from a peaty layer that abruptly changed to a light-colored mud and results of microfossil analyses (pollen and diatoms from 57 and 13 samples, respectively). They attributed the submergence events to coseismic deformation associated with earthquakes in the Fujikawa-kako fault zone or Suruga Trough. Here I reevaluated the micropaleontology of this area using 200 samples from 15 cores to reconstruct the full history of coastal submergence during the last few thousand years. The submergence events were shown not by lithostratigraphy but clearly by changes in fossil diatom assemblages and plant macrofossils. For example, at about 2.3 m and 3.1 m below the ground surface, while aerophilic diatoms (such as Diadesmis contenta and Diploneis elliptica) dominate the underlying peaty layer, freshwater and brackish planktonic taxa (Aulacoseira and Thalassiosira) abound in the overlying layer. As many as five such changes in diatom assemblages were found in a 8-m core and radiocarbon ages constrain the age of the entire sequence to 3500 yr BP.

PREFACE: ELC International Meeting on Inference, Computation, and Spin Glasses (ICSG2013)

NASA Astrophysics Data System (ADS)

Kabashima, Yoshiyuki; Hukushima, Koji; Inoue, Jun-ichi; Tanaka, Toshiyuki; Watanabe, Osamu

2013-12-01

The close relationship between probability-based inference and statistical mechanics of disordered systems has been noted for some time. This relationship has provided researchers with a theoretical foundation in various fields of information processing for analytical performance evaluation and construction of efficient algorithms based on message-passing or Monte Carlo sampling schemes. The ELC International Meeting on 'Inference, Computation, and Spin Glasses (ICSG2013)', was held in Sapporo 28-30 July 2013. The meeting was organized as a satellite meeting of STATPHYS25 in order to offer a forum where concerned researchers can assemble and exchange information on the latest results and newly established methodologies, and discuss future directions of the interdisciplinary studies between statistical mechanics and information sciences. Financial support from Grant-in-Aid for Scientific Research on Innovative Areas, MEXT, Japan 'Exploring the Limits of Computation (ELC)' is gratefully acknowledged. We are pleased to publish 23 papers contributed by invited speakers of ICSG2013 in this volume of Journal of Physics: Conference Series. We hope that this volume will promote further development of this highly vigorous interdisciplinary field between statistical mechanics and information/computer science. Editors and ICSG2013 Organizing Committee: Koji Hukushima Jun-ichi Inoue (Local Chair of ICSG2013) Yoshiyuki Kabashima (Editor-in-Chief) Toshiyuki Tanaka Osamu Watanabe (General Chair of ICSG2013)

Low-metallicity Star Formation (IAU S255)

NASA Astrophysics Data System (ADS)

Hunt, Leslie K.; Madden, Suzanne C.; Schneider, Raffaella

2009-01-01

'Shea and Michael L. Norman; 16. Damped Lyα systems as probes of chemical evolution over cosmological timescales Miroslava Dessauges-Zavadsky; 17. Connecting high-redshift galaxy populations through observations of local damped Lyman alpha dwarf galaxies Regina E. Schulte-Ladbeck; 18. Chemical enrichment and feedback in low metallicity environments: constraints on galaxy formation Francesca Matteucci; 19. Effects of reionization on dwarf galaxy formation Massimo Ricotti; 20. The importance of following the evolution of the dust in galaxies on their SEDs A. Schurer, F. Calura, L. Silva, A. Pipino, G. L. Granato, F. Matteucci and R. Maiolino; 21. About the chemical evolution of dSphs (and the peculiar globular cluster ωCen) Andrea Marcolini and Annibale D'Ercole; 22. Young star clusters in the small Magellanic cloud: impact of local and global conditions on star formation Elena Sabbi, Linda J. Smith, Lynn R. Carlson, Antonella Nota, Monca Tosi, Michele Cignoni, Jay S. Gallagher III, Marco Sirianni and Margaret Meixner; 23. Modeling the ISM properties of metal-poor galaxies and gamma-ray burst hosts Emily M. Levesque, Lisa J. Kewley, Kirsten Larson and Leonie Snijders; 24. Dwarf galaxies and the magnetisation of the IGM Uli Klein; Session III. Explosive Events in Low-Metallicity Environments: 25. Supernovae and their evolution in a low metallicity ISM Roger A. Chevalier; 26. First stars - type Ib supernovae connection Ken'ichi Nomoto, Masaomi Tanaka, Yasuomi Kamiya, Nozomu Tominaga and Keiichi Maeda; 27. Supernova nucleosynthesis in the early universe Nozomu Tominaga, Hideyuki Umeda, Keiichi Maeda, Ken'ichi Nomoto and Nobuyuki Iwamoto; 28. Powerful explosions at Z = 0? Sylvia Ekström, Georges Meynet, Raphael Hirschi and André Maeder; 29. Wind anisotropy and stellar evolution Cyril Georgy, Georges Meynet and André Maeder; 30. Low-mass and metal-poor gamma-ray burst

Low-Metallicity Star Formation: From the First Stars to Dwarf Galaxies

NASA Astrophysics Data System (ADS)

Hunt, Leslie K.; Madden, Suzanne C.; Schneider, Raffaella

2008-12-01

'Shea and Michael L. Norman; 16. Damped Lyα systems as probes of chemical evolution over cosmological timescales Miroslava Dessauges-Zavadsky; 17. Connecting high-redshift galaxy populations through observations of local damped Lyman alpha dwarf galaxies Regina E. Schulte-Ladbeck; 18. Chemical enrichment and feedback in low metallicity environments: constraints on galaxy formation Francesca Matteucci; 19. Effects of reionization on dwarf galaxy formation Massimo Ricotti; 20. The importance of following the evolution of the dust in galaxies on their SEDs A. Schurer, F. Calura, L. Silva, A. Pipino, G. L. Granato, F. Matteucci and R. Maiolino; 21. About the chemical evolution of dSphs (and the peculiar globular cluster ωCen) Andrea Marcolini and Annibale D'Ercole; 22. Young star clusters in the small Magellanic cloud: impact of local and global conditions on star formation Elena Sabbi, Linda J. Smith, Lynn R. Carlson, Antonella Nota, Monca Tosi, Michele Cignoni, Jay S. Gallagher III, Marco Sirianni and Margaret Meixner; 23. Modeling the ISM properties of metal-poor galaxies and gamma-ray burst hosts Emily M. Levesque, Lisa J. Kewley, Kirsten Larson and Leonie Snijders; 24. Dwarf galaxies and the magnetisation of the IGM Uli Klein; Session III. Explosive Events in Low-Metallicity Environments: 25. Supernovae and their evolution in a low metallicity ISM Roger A. Chevalier; 26. First stars - type Ib supernovae connection Ken'ichi Nomoto, Masaomi Tanaka, Yasuomi Kamiya, Nozomu Tominaga and Keiichi Maeda; 27. Supernova nucleosynthesis in the early universe Nozomu Tominaga, Hideyuki Umeda, Keiichi Maeda, Ken'ichi Nomoto and Nobuyuki Iwamoto; 28. Powerful explosions at Z = 0? Sylvia Ekström, Georges Meynet, Raphael Hirschi and André Maeder; 29. Wind anisotropy and stellar evolution Cyril Georgy, Georges Meynet and André Maeder; 30. Low-mass and metal-poor gamma-ray burst

A probabilistic tornado wind hazard model for the continental United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hossain, Q; Kimball, J; Mensing, R

A probabilistic tornado wind hazard model for the continental United States (CONUS) is described. The model incorporates both aleatory (random) and epistemic uncertainties associated with quantifying the tornado wind hazard parameters. The temporal occurrences of tornadoes within the continental United States (CONUS) is assumed to be a Poisson process. A spatial distribution of tornado touchdown locations is developed empirically based on the observed historical events within the CONUS. The hazard model is an aerial probability model that takes into consideration the size and orientation of the facility, the length and width of the tornado damage area (idealized as a rectanglemore » and dependent on the tornado intensity scale), wind speed variation within the damage area, tornado intensity classification errors (i.e.,errors in assigning a Fujita intensity scale based on surveyed damage), and the tornado path direction. Epistemic uncertainties in describing the distributions of the aleatory variables are accounted for by using more than one distribution model to describe aleatory variations. The epistemic uncertainties are based on inputs from a panel of experts. A computer program, TORNADO, has been developed incorporating this model; features of this program are also presented.« less

Inter-comparison of Rainfall Estimation from Radar and Satellite During 2016 June 23 Yancheng Tornado Event over Eastern China

NASA Astrophysics Data System (ADS)

Huang, C.; Chen, S.; Liang, Z.; Hu, B.

2017-12-01

ABSTRACT: On the afternoon of June 23, 2016, Yancheng city in eastern China was hit by a severe thunderstorm that produced a devastating tornado. This tornado was ranked as an EF4 on the Enhanced Fujita scale by China Meteorological Administration, and killed at least 99 people and injured 846 others (152 seriously). This study evaluates rainfall estimates from ground radar network and four satellite algorithms with a relatively dense rain gauge network over eastern China including Jiangsu province and its adjacent regions for the Yancheng June 23 Tornado extreme convective storm in different spatiotemporal scales (from 0.04° to 0.1° and hourly to event total accumulation). The radar network is composed of about 6 S-band Doppler weather radars. Satellite precipitation products include Integrated Multi-satellitE Retrievals for GPM (IMERG), Climate Prediction Center morphing technique (CMORPH), Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Cloud Classification System (PERSIANN-CCS), and Global Satellite Mapping of Precipitation (GSMap). Relative Bias (RB), Root-Mean-Squared Error (RMSE), Correlation Coefficient (CC), Probability Of Detection (POD), False Alarm Ratio (FAR), and Critical Success Index (CSI) are used to quantify the performance of these precipitation products.

Metal-Organic Polyhedron Capped with Cucurbit[8]uril Delivers Doxorubicin to Cancer Cells.

PubMed

Samanta, Soumen K; Moncelet, Damien; Briken, Volker; Isaacs, Lyle

2016-11-02

Self-assembly of ligand 1 and Pd(NO 3 ) 2 delivers Fujita-type metal-organic polyhedron (MOP) 3 which bears 24 covalently attached methyl viologen units on its external surface, as evidenced by 1 H NMR, diffusion-ordered spectroscopy NMR, electrospray mass spectrometry, transmission electron microscopy, and atomic force microscopy measurements. MOP 3 undergoes noncovalent complexation with cucurbit[n]urils to yield MOPs 4-6 with diameter ≈5-6 nm. MOP 5 can be fully loaded with doxorubicin (DOX) prodrug 2 via hetero-ternary complex formation to yield 7. The MOPs exhibit excellent stability toward neutral to slightly acidic pH in 10 mM sodium phosphate buffer, mitigating the concern of disassembly during circulation. The results of MTS assays show that MOP 7 is 10-fold more cytotoxic toward HeLa cells than equimolar quantities of DOX prodrug 2. The enhanced cytotoxicity can be traced to a combination of enhanced cellular uptake of 7 and DOX release as demonstrated by flow cytometry and confocal fluorescence microscopy. The confluence of properties imparted by the polycationic MOP architecture and plug-and-play CB[n] complexation provides a potent new platform for drug delivery application.

Effects of Magnetic Field and Rotation on 3P2 Superfluidity in Neutron Stars

NASA Astrophysics Data System (ADS)

Masuda, Kota; Nitta, Muneto

2014-09-01

It is believed that an anisotropic 3P2 superfluid state is realized in the core of neutron stars. Historically, a lot of works (Anderson et al. (1961), Hoffberg et al. (1970) and Tamagaki (1970)) discussed the properties of 3P2 superfluid state. Ginzburg-Landau (GL) equation was derived by Fujita, Tsuneto (1972) and Richardson (1972). After that, Mermin (1974) solved the problem of minimizing GL free energy density for d-wave pairing and showed what ground states are realized. By using these results, Sauls and Serene (1978) concluded that the unitary phase is realized in BCS limit, and Sauls et al. (1982) showed 3P2 vortices have a spontaneous magnetization. In this presentation, we firstly introduce GL equation and show some analogy to that of spin2-BEC. In BCS limit, degenerate ground states are parameterized by one parameter. We show effects of gradient terms, magnetic field and rotation on ground states and half-quantized 3P2 vortices are the most stable states under certain conditions. Next, by using an anisotropic GL equation, we discuss a spontaneous magnetization caused by half-quantized 3P2 vortices and compare results with that of integer vortices. Finally, we comment on possible effects of 3P2 superfluid state on neutron star observables. It is believed that an anisotropic 3P2 superfluid state is realized in the core of neutron stars. Historically, a lot of works (Anderson et al. (1961), Hoffberg et al. (1970) and Tamagaki (1970)) discussed the properties of 3P2 superfluid state. Ginzburg-Landau (GL) equation was derived by Fujita, Tsuneto (1972) and Richardson (1972). After that, Mermin (1974) solved the problem of minimizing GL free energy density for d-wave pairing and showed what ground states are realized. By using these results, Sauls and Serene (1978) concluded that the unitary phase is realized in BCS limit, and Sauls et al. (1982) showed 3P2 vortices have a spontaneous magnetization. In this presentation, we firstly introduce GL equation and

Synergetic Organization in Speech Rhythm

NASA Astrophysics Data System (ADS)

Cummins, Fred

The Speech Cycling Task is a novel experimental paradigm developed together with Robert Port and Keiichi Tajima at Indiana University. In a task of this sort, subjects repeat a phrase containing multiple prominent, or stressed, syllables in time with an auditory metronome, which can be simple or complex. A phase-based collective variable is defined in the acoustic speech signal. This paper reports on two experiments using speech cycling which together reveal many of the hallmarks of hierarchically coupled oscillatory processes. The first experiment requires subjects to place the final stressed syllable of a small phrase at specified phases within the overall Phrase Repetition Cycle (PRC). It is clearly demonstrated that only three patterns, characterized by phases around 1/3, 1/2 or 2/3 are reliably produced, and these points are attractors for other target phases. The system is thus multistable, and the attractors correspond to stable couplings between the metrical foot and the PRC. A second experiment examines the behavior of these attractors at increased rates. Faster rates lead to mode jumps between attractors. Previous experiments have also illustrated hysteresis as the system moves from one mode to the next. The dynamical organization is particularly interesting from a modeling point of view, as there is no single part of the speech production system which cycles at the level of either the metrical foot or the phrase repetition cycle. That is, there is no continuous kinematic observable in the system. Nonetheless, there is strong evidence that the oscopic behavior of the entire production system is correctly described as hierarchically coupled oscillators. There are many parallels between this organization and the forms of inter-limb coupling observed in locomotion and rhythmic manual tasks.

Can We Build an Open-Science Model to Fund Young, Risky, Blue-Sky Research? First Insights into Funding Geoscientists Via Thinkable.Org

NASA Astrophysics Data System (ADS)

McNeil, B.

2014-12-01

Some of the biggest discoveries and advances in geoscience research have come from purely curiosity-driven, blue-sky research. Marine biologist Osamu Shimomura's discovery of Green-Fluorecent Protein (GFP) in the 1960s during his postdoc is just one example, which came about through his interest and pursuit of how certain jellyfish bioluminescence. His discovery would eventually revolutionise medicine, culminating in a Nobel Prize in Chemistry in 2008. Despite the known importance of "blue-sky" research that doesn't have immediate commercial or social applications, it continues to struggle for funding from both government and industry. Success rates for young scientists also continue to decline within the government competitive granting models due to the importance of track records, yet history tells us that young scientists tend to come up with science's greatest discoveries. The digital age however, gives us a new opportunity to create an alternative and sustainable funding model for young, risky, blue-sky science that tends not to be supported by governments and industry anymore. Here I will discuss how new digital platforms empower researchers and organisations to showcase their research using video, allowing wider community engagment and funding that can be used to directly support young, risky, blue-sky research that is so important to the future of science. I will then talk about recent experience with this model from some ocean researchers who used a new platform called thinkable.org to showcase and raise funding via the public.

Raphidascaris (Raphidascaris) macrouri n. sp. (Nematoda: Anisakidae) from two deep-sea macrourid fishes in the Western Mediterranean: Morphological and molecular characterisations.

PubMed

Pérez-i-García, David; Constenla, María; Carrassón, Maite; Montero, Francisco E; Soler-Membrives, Anna; González-Solís, David

2015-10-01

A new nematode species, Raphidascaris (Raphidascaris) macrouri n. sp. (Anisakidae), is described from male and female specimens found in the intestine, and occasionally in stomach and pyloric caeca, of two deep-water macrourid fishes (Gadiformes) off Barcelona, Mediterranean Sea: Nezumia aequalis (Günther) (type-host) and Trachyrincus scabrus (Rafinesque). Based on light and scanning electron microscopy examination, the new species shows similar morphological features as the other four valid species of the subgenus Raphidascaris Railliet & Henry, 1915, but it differs from Raphidascaris (Raphidascaris) acus (Bloch, 1779), Raphidascaris (Raphidascaris) lutjani Olsen, 1952 and Raphidascaris (Raphidascaris) mediterraneus Lèbre & Petter, 1983 in the high number of precloacal papillae (23-32) and from Raphidascaris (Raphidascaris) gigi Fujita, 1928 in the length of the spicules. Moreover, Raphidascaris (Raphidascaris) macrouri n. sp. exhibits a high variability on the number and distribution of caudal papillae, which was not recorded in the other four mentioned species. This is the first species of this subgenus reported from the family Macrouridae. Sequences of ITS1-5.8S-ITS2 region are analysed and compared with closely related nematode species. Molecular analysis confirmed the uniformity of the R. (R.) macrouri n. sp. between hosts. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Near-ground tornado wind fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, J.R.

1984-07-01

A study of near-ground tornado wind fields has been conducted by inspecting damage and debris patterns found in tornado damage paths. Because there were no significant tornado events (F4 or greater) during the contract performance period, data from the literature and the files of the Institute for Disaster Research were used to perform the analyses. The results indicate: (1) maximum tornado wind speed ever experienced or expected is in the range of 250 to 300 mph; (2) appearance of damage, taken by itself, is a misleading parameter of tornado intensity. Type of construction, age of construction, materials and other constructionmore » features significantly affect structural performance of a building subjected to wind loads and should be taken into account in assigning Fujita-Scale ratings; (3) damage to forests gives a good indication of tornado wind field flow patterns, but do not give verifiable values of wind speed; (4) factors such as translational speed, wind direction and path width affect appearance of damage or a tornado; and (5) even the most awesome appearing missiles do not require incredible wind speeds to explain them. Some progress in computer simulation of tornado missiles have been made. 31 references, 8 figures, 2 tables.« less

Proposed characterization of tornadoes and hurricanes by area and intensity

NASA Technical Reports Server (NTRS)

Fujita, T. T.

1971-01-01

Results of the 1968 through 1970 Tornado Watch Experiment conducted jointly by NASA and NOAA suggested the necessity of characterizing individual tornadoes in order to improve the identity of tornado-producing nephsystems. An attempt was made, therefore, to categorize each tornado by its intensity and area. Fujita-scale wind and corresponding damage categories were devised to classify tornadoes as Gale (F0), Weak (F1), Strong (F2), Severe (F3), Devastating (F4), and Incredible (F5). Additionally, individual tornado areas were also categorized as Trace (TR), Decimicro (DM), Micro (MI), Meso (ME), Marco (MA), Giant (GI), and Decagiant (DG), thus permitting characterizing of a tornado by a combination of intensity and area, such as weak decimicro tornado, severe meso tornado, or incredible giant tornado. A test characterization of 156 Japanese tornadoes in 1950-69 was accomplished for comparison with 893 U.S. tornadoes in 1965. Unexpectedly, the percentage distribution of intensity and individual area of U.S. and Japanese tornadoes is very similar except for large and/or intense ones. Intensity distribution within the Dallas and Fargo tornadoes of 1957 was also studied in detail. It was also found that the F-scale variation along the paths of family tornadoes shows an intensity oscillation with a 45-min interval.

Lower Blood Pressure-Induced Renal Hypoperfusion Promotes Cisplatin-Induced Nephrotoxicity.

PubMed

Mizuno, Tomohiro; Hayashi, Takahiro; Shimabukuro, Yuka; Murase, Maho; Hayashi, Hiroki; Ishikawa, Kazuhiro; Takahashi, Kazuo; Yuzawa, Yukio; Yamada, Shigeki; Nagamatsu, Tadashi

2016-01-01

Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels ≤3.5 mg/dl. Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 ± 23.8 and 55.0 ± 20.4 mg/m2, respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment. © 2016 S. Karger AG, Basel.

Calcium carbonate precipitation rate as a function of ion ratio in the presence & absence of Sr2+

NASA Astrophysics Data System (ADS)

Gebrehiwet, T.; Beig, M. S.; Fujita, Y.; Redden, G. D.; Smith, R. W.

2010-12-01

Tsigabu Gebrehiwet 1*, Mikala Beig 2, Yoshiko Fujita 3, George Redden 3 and Robert W. Smith 1 1University of Idaho, 1776 Science Center Dr, Idaho Falls,ID, 83402 (*tgebrehiwet@uidaho.edu; smithbob@uidaho.edu ) 27963 Grasmere Dr.Boulder, CO 80301(mbeig@alumni.rice.edu) 3Idaho National Laboratory, MS 2208, Idaho Falls, ID 83415 (Yoshiko.Fujita@inl.gov; George.Redden@inl.gov) Engineered in situ precipitation of calcium carbonate is a proposed strategy for remediating toxic or radioactive metals (e.g., Sr2+)in subsurface environments as well as for modifying the physical properties (e.g., stiffness, permeability) of geomedia. Inducing the precipitation reaction will likely involve manipulating the geochemical conditions by adding calcium, (bi)carbonate, or both, and relying on mixing of the two reactants. Under these conditions, the ratio of Ca2+ to CO32- will vary with distance from the mixing interface, and for most or all of the porous medium, a 1:1 stoichiometry between calcium and carbonate is unlikely to be achieved. Indeed, in engineered systems where rapid treatment is an important objective, very steep ion concentration gradients may be generated, which would result in local reactant ratios varying from very small to very large over short distances, depending on the mixing geometry and particular chemical composition of the mixing fluids. This in turn has an impact on the rate of mineral precipitation. Typically, the rate of calcium carbonate precipitation is expressed with an affinity-based rate law of the type: Rate = k(Ω-1)n, where k is a rate constant, Ω is the saturation state for the mineral (e.g., calcite), and n is an empirical reaction order. The saturation state Ω is defined as the ratio of the ion activity product to the mineral solubility product. In this expression, the rate is simply dependent on the value of Ω; the actual activities of the individual ions (Ca2+ and CO32-) do not appear in the expression. In support of the development of

On the Global Regularity of a Helical-Decimated Version of the 3D Navier-Stokes Equations

NASA Astrophysics Data System (ADS)

Biferale, Luca; Titi, Edriss S.

2013-06-01

We study the global regularity, for all time and all initial data in H 1/2, of a recently introduced decimated version of the incompressible 3D Navier-Stokes (dNS) equations. The model is based on a projection of the dynamical evolution of Navier-Stokes (NS) equations into the subspace where helicity (the L 2-scalar product of velocity and vorticity) is sign-definite. The presence of a second (beside energy) sign-definite inviscid conserved quadratic quantity, which is equivalent to the H 1/2-Sobolev norm, allows us to demonstrate global existence and uniqueness, of space-periodic solutions, together with continuity with respect to the initial conditions, for this decimated 3D model. This is achieved thanks to the establishment of two new estimates, for this 3D model, which show that the H 1/2 and the time average of the square of the H 3/2 norms of the velocity field remain finite. Such two additional bounds are known, in the spirit of the work of H. Fujita and T. Kato (Arch. Ration. Mech. Anal. 16:269-315, 1964; Rend. Semin. Mat. Univ. Padova 32:243-260, 1962), to be sufficient for showing well-posedness for the 3D NS equations. Furthermore, they are directly linked to the helicity evolution for the dNS model, and therefore with a clear physical meaning and consequences.

Numerical simulation of tornadoes' meteorological conditions over Greece: A case study of tornadic activity over NW Peloponnese on March 25, 2009

NASA Astrophysics Data System (ADS)

Matsangouras, Ioannis T.; Nastos, Panagiotis T.; Pytharoulis, Ioannis

2014-05-01

Recent research revealed that NW Peloponnese, Greece is an area that favours pre-frontal tornadic incidence. This study presents the results of the synoptic analysis of the meteorological conditions during a tornado event over NW Peloponnese on March 25, 2009. Further, the role of topography in tornado genesis is examined. The tornado was formed approximately at 10:30 UTC, south-west of Vardas village, crossed the Nea Manolada and faded away at Lappas village, causing several damage. The length of its track was approximately 9-10 km and this tornado was characterized as F2 (Fujita scale) or T4-T5 in TORRO intensity scale. Synoptic analysis was based on ECMWF datasets, as well as on daily composite mean and anomaly of the geopotential heights at the middle and lower troposphere from NCEP/NCAR reanalysis. In addition, numerous datasets derived from weather observations and remote sensing were used in order to interpret better the examined extreme event. Finally, a numerical simulation was performed using the non-hydrostatic Weather Research and Forecasting model (WRF), initialized with ECMWF gridded analyses, with telescoping nested grids that allow the representation of atmospheric circulations ranging from the synoptic scale down to the meso-scale. In the numerical simulations the topography of the inner grid was modified by: a) 0% (actual topography) and b) -100% (without topography).

Cucurbit[7]uril Enables Multi-Stimuli-Responsive Release from the Self-Assembled Hydrophobic Phase of a Metal Organic Polyhedron.

PubMed

Samanta, Soumen K; Quigley, Jeffrey; Vinciguerra, Brittany; Briken, Volker; Isaacs, Lyle

2017-07-05

Mixed self-assembly of ligands 1, 2, 1,6-hexanediamine (HDA), and Pd(NO 3 ) 2 afforded Fujita-type metal organic polyhedron MOP1 (diameter ≈ 8.2 nm), which is covalently functionalized with an average of 18 cucurbit[7]uril (CB[7]) units, as evidenced by 1 H NMR, diffusion-ordered spectroscopy NMR, and transmission electron microscopy measurements. By virtue of the host-guest properties of CB[7], the inner cavity of MOP can be rendered hydrophobic by using octadecyl HDA (3) as guest during the self-assembly process. The hydrophobic cavity was successfully utilized to trap the hydrophobic dye Nile Red (NR) and the anticancer drug doxorubicin (DOX). The stimuli-responsive release of encapsulated NR or DOX occurs (1) upon addition of a competitive binder (e.g., adamantane ammonium (ADA)) for CB[7], (2) by a dual pH-chemical stimulus involving the protonation state change of adamantane carboxylate at pH 5.8, and (3) by a dual pH-photochemical stimulus involving photoisomerization of trans-6 to cis-6 at pH 5.8. NR is released from NR@MOP2 within HeLa cancer cells. This body of work suggests that the covalent attachment of cucurbit[n]uril to metal organic polyhedra constitutes a promising vehicle for the development of both diagnostic and therapeutic nanoparticles.

Get off the bus: sound strategy for injury prevention during a tornado?

PubMed

Comstock, R Dawn; Mallonee, Sue

2005-01-01

On 08 May 2003, a tornado categorized as an F-3 on the Fujita Tornado Scale (the "F Scale") struck an Oklahoma City, Oklahoma commuter bus carrying 24 passengers. The driver evacuated several passengers before the tornado struck. The tornado rolled the bus, and pelted it with debris. A case-series investigation of tornado-related injuries was conducted among passengers who were evacuated to a ditch and those who remained on the bus when the tornado struck. Nineteen of 24 passengers sought care for injuries at hospital emergency departments (injury rate = 79.2%). While a greater number of passengers who were outside the bus when the tornado struck (11) sought care for injuries than did those who remained on the bus (8); passengers outside of the bus suffered fewer injuries than did those who remained on the bus (median number of injuries 3 versus 4), and their injuries were less severe (median injury severity score (ISS) 1 versus 4). For persons caught in motor vehicles during tornado events, this study supports currently accepted recommendations to immediately evacuate and lie in a low-lying area away from motor vehicles if other shelter is unavailable. However, generalizing the experience of bus passengers to automobile drivers might be inappropriate because buses lack the safety features that might protect automobile drivers from tornado-related injuries.

ENVIRONMENTAL MANAGEMENT SCIENCE PROGRAM PROJECT NUMBER 87016 CO-PRECIPITATION OF TRACE METALS IN GROUNDWATER AND VADOSE ZONE CALCITE: IN SITU CONTAINMENT AND STABILIZATION OF STRONTIUM-90 AND OTHER DIVALENT METALS AND RADIONUCLIDES AT ARID WESTERN DOE SITES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferris, F. Grant; Fujita, Yoshiko; Smith, Robert W.

2004-06-15

Radionuclide and metal contaminants are present in the vadose zone and groundwater throughout the U.S. Department of Energy (DOE) weapons complex. In situ containment and stabilization of these contaminants in vadose zones or groundwater is a cost-effective treatment strategy. Our facilitated approach relies upon the hydrolysis of introduced urea to cause the acceleration of calcium carbonate precipitation (and trace metal coprecipitation) by increasing groundwater pH and alkalinity (Fujita et al., 2000; Warren et al., 2001). Subsurface urea hydrolysis is catalyzed by the urease enzyme, which may be either introduced with the urea or produced in situ by ubiquitous subsurface ureamore » hydrolyzing microorganisms. Because the precipitation processes are irreversible and many western aquifers are saturated with respect to calcite, the co-precipitated metals and radionuclides will be effectively removed from groundwater. The rate at which trace metals are incorporated into calcite is a function of calcite precipitation kinetics, adsorption interactions between the calcite surface and the trace metal in solution (Zachara et al., 1991), solid solution properties of the trace metal in calcite (Tesoriero and Pankow, 1996), and also the surfaces upon which the calcite is precipitating. A fundamental understanding of the coupling of calcite precipitation and trace metal partitioning, and how this occurs in aquifers and vadose environments is lacking. This report summarizes work undertaken during the second year of this project.« less

ENVIRONMENTALMANAGEMENT SCIENCE PROGRAM PROJECT NUMBER 87016 CO-PRECIPITATION OF TRACEMETALS INGROUNDWATER AND VADOSE ZONE CALCITE: IN SITU CONTAINMENT AND STABILIZATION OF STRONTIUM-90 ANDOTHER DIVALENT METALS AND RADIONUCLIDES AT ARIDWESTERN DOE SITES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferris, F. Grant; Fujita, Yoshiko; Smith, Robert W.

2004-06-15

Radionuclide and metal contaminants are present in the vadose zone and groundwater throughout the U.S. Department of Energy (DOE) weapons complex. In situ containment and stabilization of these contaminants in vadose zones or groundwater is a cost-effective treatment strategy. Our facilitated approach relies upon the hydrolysis of introduced urea to cause the acceleration of calcium carbonate precipitation (and trace metal coprecipitation) by increasing groundwater pH and alkalinity (Fujita et al., 2000; Warren et al., 2001). Subsurface urea hydrolysis is catalyzed by the urease enzyme, which may be either introduced with the urea or produced in situ by ubiquitous subsurface ureamore » hydrolyzing microorganisms. Because the precipitation processes are irreversible and many western aquifers are saturated with respect to calcite, the co-precipitated metals and radionuclides will be effectively removed from groundwater. The rate at which trace metals are incorporated into calcite is a function of calcite precipitation kinetics, adsorption interactions between the calcite surface and the trace metal in solution (Zachara et al., 1991), solid solution properties of the trace metal in calcite (Tesoriero and Pankow, 1996), and also the surfaces upon which the calcite is precipitating. A fundamental understanding of the coupling of calcite precipitation and trace metal partitioning, and how this occurs in aquifers and vadose environments is lacking. This report summarizes work undertaken during the second year of this project.« less

Use of incidentally encoded memory from a single experience in cats.

PubMed

Takagi, Saho; Tsuzuki, Mana; Chijiiwa, Hitomi; Arahori, Minori; Watanabe, Arii; Saito, Atsuko; Fujita, Kazuo

2017-08-01

We examined whether cats could retrieve and utilize incidentally encoded information from a single past event in a simple food-exploration task previously used for dogs (Fujita et al., 2012). In Experiment 1, cats were led to four open, baited containers and allowed to eat from two of them (Exposure phase). After a 15-min delay during which the cats were absent and all containers were replaced with empty ones, the cats were unexpectedly returned to the room and allowed to explore the containers (Test phase). Although the cats' first choice of container to visit was random, they explored containers from which they had not previously eaten for longer than those from which they did previously eat. In the Exposure phase of Experiment 2, two containers held food, one held a nonedible object, and the fourth was empty. Cats were allowed to eat from one of them. In the post-delay Test phase, the cats first visited the remaining baited-uneaten container significantly more often than chance and they spent more time exploring this container. Because the cats' behavior in the Test phase cannot be explained by association of the container with a pleasant experience (eating), the results suggest that cats retrieved and utilized "what" and "where" information from an incidentally encoded memory from a single experience. Copyright © 2017 Elsevier B.V. All rights reserved.

PREFACE: International Conference on High Pressure Science and Technology, Joint AIRAPT-22 & HPCJ-50

NASA Astrophysics Data System (ADS)

Viña, Luis; Tejedor, Carlos; Calleja, José M.

2010-01-01

The International Joint AIRAPT-22 & HPCJ-50 Conference was held in Odaiba, Tokyo, on 26-31 July 2009. About 480 scientists from 24 countries attended the conference and 464 papers, including 3 plenary lectures, 39 invited talks, and 156 oral presentations, were presented. It is my great pleasure to present this proceedings volume, which is based on the high quality scientific works presented at the conference. The International AIRAPT conference has been held every two years in various countries around the world since 1965, while High Pressure Conference of Japan (HPCJ) has been held annually since 1959 in various Japanese cities. Pressure is a fundamental parameter to control the property of matter. As a result, both AIRAPT and HPCJ have become highly multidisciplinary, and cover Physics, Chemistry, Materials Science, Earth and Planetary Sciences, Biosciences, Food Science, and Technology. Although each discipline has a unique target, they all have high-pressure research in common. This proceedings volume includes about 200 papers of state-of-the-art studies from numerous fields. I hope this proceedings volume provides excellent pieces of information in various fields to further advance high-pressure research. Conference logo Takehiko Yagi Conference Chairman Institute for Solid State Physics The University of Tokyo 7 December 2009 Conference photograph Participants at the conference venue, Tokyo International Exchange Center, Odaiba, Tokyo, Japan. Editor in Chief TAKEMURA Kenichi National Institute for Materials Science, Japan Editorial board Tadashi KONDO Osaka University, Japan Hitoshi MATSUKI The University of Tokushima, Japan Nobuyuki MATUBAYASI Kyoto University, Japan Yoshihisa MORI Okayama University of Science, Japan Osamu OHTAKA Osaka University, Japan Chihiro SEKINE Muroran Institute of Technology, Japan

Another Nobel Prize linked to synchrotron radiation work

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasnain, S.

The 2008 Nobel Prize in Chemistry went to Osamu Shimomura, Martin Chalfie and Roger Tsien 'for the discovery and development of the green fluorescent protein, GFP'. This year's Nobel Prize in Chemistry rewards the initial discovery of GFP and a series of important developments which have led to its use as a tagging tool in bioscience. By using DNA technology, researchers can now connect GFP to other interesting, but otherwise invisible, proteins. This glowing marker allows the movements, positions and interactions of the tagged proteins to be monitored. Osamu Shimomura was the first to isolate GFP from the jellyfish Aequoreamore » victoria, found off the west coast of North America, and discovered the protein's green glow [Shimomura et al. (1962). J. Cell. Comp. Physiol. 59, 223-240]. Martin Chalfie demonstrated the value of GFP as a luminous genetic tag. In one of his first experiments he coloured six individual cells in the transparent roundworm Caenorhabditis elegans with the aid of GFP. He had obtained the GFP gene (gfp) clone from Prasher [Prasher et al. (1992). Gene, 111, 229-233] and expressed it in E. coli. The GFP protein displayed a bright green fluorescence in this heterologous organism, suggesting that it could indeed serve as a versatile genetic marker in virtually all organisms. Chalfie transformed C. elegans with gfp under the control of a promoter regulating the expression of {beta}-tubulin, abundant in six touch receptor neurons in C. elegans. The organism subsequently expressed GFP from distinct positions in its body and at distinct times in its development [Chalfie et al. (1994). Science, 263, 802-805]. Roger Tsien contributed to the general understanding of how GFP glows by determining the formation of the GFP chromophore, a chemical group that absorbs and emits light. Tsien is best known for extending the colour palette of GFP beyond green, allowing researchers to follow several different biological processes at the same time. According to

The Microwave Spectroscopy of Aminoacetonitrile in the Vibrational Excited States 2

NASA Astrophysics Data System (ADS)

Fujita, Chiho; Higurashi, Haruka; Ozeki, Hiroyuki; Kobayashi, Kaori

2016-06-01

Aminoacetonitrile (NH_2CH_2CN) is a potential precursor of the simplest amino acid, glycine in the interstellar space and was detected toward SgrB2(N). We have extended measurements up to 1.3 THz so that the strongest transitions that may be found in the terahertz region should be covered. Aminoacetonitrile has a few low-lying vibrational excited states and indeed the pure rotational transitions in these vibrational excited states were found. The pure rotational transitions in six vibrational excited states in the 80-180 GHz range have been assigned and centrifugal distortion constants up to the sextic terms were determined. Based on spectral intensities and the vibrational information from Bak et al., They were assigned to the 3 low-lying fundamentals, 1 overtone and 2 combination bands. In the submillimeter wavelength region, perturbations were recognized and some of the lines were off by more than a few MHz. At this moment, these perturbed transitions are not included in our analysis. A. Belloche, K. M. Menten, C. Comito, H. S. P. Müller, P. Schilke, J. Ott, S. Thorwirth, and C. Hieret, 2008, Astronom. & Astrophys. 482, 179 (2008). Y. Motoki, Y. Tsunoda, H. Ozeki, and K. Kobayashi, Astrophys. J. Suppl. Ser. 209, 23 (2013). B. Bak, E. L. Hansen, F. M. Nicolaisen, and O. F. Nielsen, Can. J. Phys. 53, 2183 (1975) C. Fujita, H. Ozeki, and K. Kobayashi, 70th International Symposium on Molecular Spectroscopy (2015), MH14.

Tornado Damage Assessment: Reconstructing the Wind Through Debris Tracking and Treefall Pattern Analysis

NASA Astrophysics Data System (ADS)

Godfrey, C. M.; Peterson, C. J.; Lombardo, F.

2017-12-01

Efforts to enhance the resilience of communities to tornadoes requires an understanding of the interconnected nature of debris and damage propagation in both the built and natural environment. A first step toward characterizing the interconnectedness of these elements within a given community involves detailed post-event surveys of tornado damage. Such damage surveys immediately followed the 22 January 2017 EF3 tornadoes in the southern Georgia towns of Nashville and Albany. After assigning EF-scale ratings to impacted structures, the authors geotagged hundreds of pieces of debris scattered around selected residential structures and outbuildings in each neighborhood and paired each piece of debris with its source structure. Detailed information on trees in the vicinity of the structures supplements the debris data, including the species, dimensions, location, fall direction, and level of damage. High-resolution satellite imagery helps to identify the location and fall direction of hundreds of additional forest trees. These debris and treefall patterns allow an estimation of the near-surface wind field using a Rankine vortex model coupled with both a tree stability model and an infrastructure fragility model that simulates debris flight. Comparisons between the modeled damage and the actual treefall and debris field show remarkable similarities for a selected set of vortex parameters, indicating the viability of this approach for estimating enhanced Fujita scale levels, determining the near-surface wind field of a tornado during its passage through a neighborhood, and identifying how debris may contribute to the overall risk from tornadoes.

Investigation into the Formation, Structure, and Evolution of an EF4 Tornado in East China Using a High-Resolution Numerical Simulation

NASA Astrophysics Data System (ADS)

Yao, Dan; Xue, Haile; Yin, Jinfang; Sun, Jisong; Liang, Xudong; Guo, Jianping

2018-04-01

Devastating tornadoes in China have received growing attention in recent years, but little is known about their formation, structure, and evolution on the tornadic scale. Most of these tornadoes develop within the East Asian monsoon regime, in an environment quite different from tornadoes in the U.S. In this study, we used an idealized, highresolution (25-m grid spacing) numerical simulation to investigate the deadly EF4 (Enhanced Fujita scale category 4) tornado that occurred on 23 June 2016 and claimed 99 lives in Yancheng, Jiangsu Province. A tornadic supercell developed in the simulation that had striking similarities to radar observations. The violent tornado in Funing County was reproduced, exceeding EF4 (74 m s-1), consistent with the on-site damage survey. It was accompanied by a funnel cloud that extended to the surface, and exhibited a double-helix vorticity structure. The signal of tornado genesis was found first at the cloud base in the pressure perturbation field, and then developed both upward and downward in terms of maximum vertical velocity overlapping with the intense vertical vorticity centers. The tornado's demise was found to accompany strong downdrafts overlapping with the intense vorticity centers. One of the interesting findings of this work is that a violent surface vortex was able to be generated and maintained, even though the simulation employed a free-slip lower boundary condition. The success of this simulation, despite using an idealized numerical approach, provides a means to investigate more historical tornadoes in China.

Usefulness of Interprofessional Education (Tsurumai-Meijo IPE) in Program Collaborating with Simulated Patients.

PubMed

Goto, Aya; Hanya, Manako; Yoshimi, Akira; Uchida, Mizuki; Takeuchi, Saori; Aida, Nobuko; Suematsu, Mina; Abe, Keiko; Yasui, Hiroki; Kamei, Hiroyuki; Noda, Yukihiro

2017-01-01

Collaboration with multiple healthcare professionals is important to provide safer and higher quality care. Interprofessional education (IPE) promotes the practice of team-based care. The establishment of Tsurumai-Meijo IPE, including interprofessional education and practice (IPEP) and video-teaching materials, was conducted in collaboration with school of medicine/nursing in Nagoya University and Fujita Health University, because Meijo University does not have its own clinical settings and faculties except for pharmacy. In the established Tsurumai-Meijo IPE, pharmacy, medicine, and nursing students interviewed simulated patients (SP) together or separately and practiced team-based care through Tsurumai-Meijo IPEP. Students could learn in advance and on their own about each professional's knowledge related to patient care by using video-teaching materials from the Meijo IPE homepage. Using a questionnaire survey at the end of program, this study was examined whether Tsurumai-Meijo IPEP, and video-teaching materials were useful for understanding importance of team-based care. More than 83% of students indicated that Tsurumai-Meijo IPE is useful on future clinical practice. This suggests that the program and materials are beneficial to the medical student education. In the optional survey of some clinical pharmacists, who had participated in Tsurumai-Meijo IPE before graduation, they utilized it in their work and it facilitated their work related to team-based care. Tsurumai-Meijo IPE collaborating with SP is likely to contribute to provide high quality and safe team-based care by taking advantage of specialized professional ability of healthcare professionals.

A forensic re-analysis of one of the deadliest European tornadoes

NASA Astrophysics Data System (ADS)

Holzer, Alois M.; Schreiner, Thomas M. E.; Púčik, Tomáš

2018-06-01

Extremely rare events with high potential impact, such as violent tornadoes, are of strong interest for climatology and risk assessment. In order to obtain more knowledge about the most extreme events, it is vital to study historical cases. The purpose of this paper is twofold: (1) to demonstrate how a windstorm catastrophe that happened 100 years ago, such as the Wiener Neustadt, Lower Austria, tornado on 10 July 1916, can be successfully re-analyzed using a forensic approach, and (2) to propose a repeatable working method for assessing damage and reconstructing the path and magnitude of local windstorm and tornado cases with sufficient historical sources. Based on the results of the forensic re-analyses, a chronology of the tornado impact is presented, followed by a description of the key tornado characteristics: a maximum intensity rating of F4, a damage path length of 20 km and a maximum visible tornado diameter of 1 km. Compared to a historical scientific study published soon after the event, additional new findings are presented, namely the existence of two predecessor tornadoes and a higher number of fatalities: at least 34 instead of 32. While the storm-scale meteorology could not be reconstructed, rich damage data sources for the urban area of Wiener Neustadt facilitated a detailed analysis of damage tracks and wind intensities within the tornado. The authors postulate the requirement for an International Fujita Scale to rate tornadoes globally in a consistent way, based on comparable damage indicators.

On the complexity of a combined homotopy interior method for convex programming

NASA Astrophysics Data System (ADS)

Yu, Bo; Xu, Qing; Feng, Guochen

2007-03-01

In [G.C. Feng, Z.H. Lin, B. Yu, Existence of an interior pathway to a Karush-Kuhn-Tucker point of a nonconvex programming problem, Nonlinear Anal. 32 (1998) 761-768; G.C. Feng, B. Yu, Combined homotopy interior point method for nonlinear programming problems, in: H. Fujita, M. Yamaguti (Eds.), Advances in Numerical Mathematics, Proceedings of the Second Japan-China Seminar on Numerical Mathematics, Lecture Notes in Numerical and Applied Analysis, vol. 14, Kinokuniya, Tokyo, 1995, pp. 9-16; Z.H. Lin, B. Yu, G.C. Feng, A combined homotopy interior point method for convex programming problem, Appl. Math. Comput. 84 (1997) 193-211.], a combined homotopy was constructed for solving non-convex programming and convex programming with weaker conditions, without assuming the logarithmic barrier function to be strictly convex and the solution set to be bounded. It was proven that a smooth interior path from an interior point of the feasible set to a K-K-T point of the problem exists. This shows that combined homotopy interior point methods can solve the problem that commonly used interior point methods cannot solveE However, so far, there is no result on its complexity, even for linear programming. The main difficulty is that the objective function is not monotonically decreasing on the combined homotopy path. In this paper, by taking a piecewise technique, under commonly used conditions, polynomiality of a combined homotopy interior point method is given for convex nonlinear programming.

3D Electromagnetic Imaging of Fluid Distribution Below the Kii Peninsula, SW Japan Forearc

NASA Astrophysics Data System (ADS)

Kinoshita, Y.; Ogawa, Y.; Ichiki, M.; Yamaguchi, S.; Fujita, K.; Umeda, K.; Asamori, K.

2017-12-01

Although Kii peninsula is located in the forearc of southwest Japan, it has high temperature hot springs and fluids from mantle are inferred from the isotopic ratio of helium. Non-volcanic tremors underneath the Kii Peninsula suggest rising fluids from the slab.Previously, in the southern part of the Kii Peninsula, wide band magnetotelluric measurements were carried out (Fujita et al. ,1997; Umeda et al., 2004). These studies could image the existence of the conductivity anomaly in the shallow and deep crust, however they used two dimensional inversions and three-dimensionality is not fully taken into consideration. As part of the "Crustal Dynamics" project, we have measured 20 more stations so that the whole wide-band MT stations constitute grids for three-dimensional modeling of the area. In total we have 51 wide-band magnetotelluric sites. Preliminary 3d inverse modeling showed the following features. (1) The high resistivity in the eastern Kii Peninsula at depths of 5-40km. This may imply consolidated magma body of Kumano Acidic rocks underlain by resistive Philippine Sea Plate which subducts with a low dip angle. (2) The northwestern part of Kii Peninsula has the shallow low resistivity in the upper crust, around which high seismicity is observed. (3) The northwestern part of the survey area has a deeper conductor. This implies a wedge mantle where the Philippine Sea subduction has a higher dip angle.

April 23, 1983 tornado at the Savannah River Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garrett, A.J.

1983-07-01

Just before 8:00 p.m. on Saturday, April 23, 1983, a small (Fl) tornado touched ground in Jackson, South Carolina and traveled northeast for several miles, passing just northwest of the SRP 700-A Area. The tornado uprooted or snapped many large trees in Jackson, and damaged several homes and buildings, including the loss of an entire roof from one store. After it passed through Jackson, the tornado damaged pine forests on the SRP border. Based on the Fujita tornado intensity scale and observed damage, the maximum winds in the tornado were probably 100 to 150 mph. Several swaths in the forestedmore » area, each several hundred yards long, were almost denuded (80 to 90% uprooting or snapping of trees). As the tornado approached A Area, it appeared to be weakening, with maximum tree losses of 30 to 50%. The A-Area meteorological tower measured winds of 62 mph before the wind sensor was blown off the tower. Damage to A Area was small, although several trailers lost windows and pieces of roofing, one trailer was overturned, and at least one small shed was demolished. The tornado continued to the northeast where it died out over the SRP forest after felling trees for several more miles. Inspection of the rest of the SRP site from a helicopter showed that no other tornados hit SRP during the April 23 storm, although other tornados hit parts of South Carolina and Georgia. It was the first known occurrence of a tornado at SRP since 1976.« less

Are Tornadoes Getting Stronger?

NASA Astrophysics Data System (ADS)

Elsner, J.; Jagger, T.

2013-12-01

A cumulative logistic model for tornado damage category is developed and examined. Damage path length and width are significantly correlated to the odds of a tornado receiving the next highest damage category. Given values for the cube root of path length and square root of path width, the model predicts a probability for each category. The length and width coefficients are insensitive to the switch to the Enhanced Fujita (EF) scale and to distance from nearest city although these variables are statistically significant in the model. The width coefficient is sensitive to whether or not the tornado caused at least one fatality. This is likely due to the fact that the dimensions and characteristics of the damage path for such events are always based on ground surveys. The model predicted probabilities across the categories are then multiplied by the center wind speed from the categorical EF scale to obtain an estimate of the highest tornado wind speed on a continuous scale in units of meters per second. The estimated wind speeds correlate at a level of .82 (.46, .95) [95% confidence interval] to wind speeds estimated independently from a doppler radar calibration. The estimated wind speeds allow analyses to be done on the tornado database that are not possible with the categorical scale. The modeled intensities can be used in climatology and in environmental and engineering applications. More work needs to be done to understand the upward trends in path length and width. The increases lead to an apparent increase in tornado intensity across all EF categories.

The occurrence of convective systems with a bow echo in warm season in Poland

NASA Astrophysics Data System (ADS)

Celiński-Mysław, Daniel; Palarz, Angelika

2017-09-01

The characteristics of occurrence of convective systems with a bow echo in Poland in the warm season between 2007 and 2014 were presented. Using the identification criteria proposed by Fujita (1978), Burke and Schultz (2004), Klimowski et al. (2000, 2004), and supplemented by Gatzen (2013), 91 bow echo cases were identified in the analysed period. Depending on the year, the maximum number of cases usually occurred in July or August. From the multi-annual perspective, 28 and 30 cases occurred in those months. The diurnal variation of bow echo occurrences showed that it developed, or entered the Polish territory, usually between the hours of 13:00 UTC and 21:00 UTC, while it disappeared or receded beyond the country border in the hours between 15:00 UTC and 23:00 UTC. The areas most exposed to the occurrence of bow echo included the northern part of Lubuskie and Wielkopolska provinces, the southern part of West Pomerania province, Łódź province and Silesia province. In the period studied, the south-western direction of movement of convective systems with a bow echo was prevalent. This direction changed, however, depending on the region and the month of occurrence. The type and development mode of a bow echo, as well as synoptic conditions conducive to its occurrence were defined for selected cases. The results showed that BECs (bow-echo complex) and BEs (classic bow echo) were the predominant types (respectively 43 and 29 cases). Bow echoes developed most frequently from a squall line, or from a combination of a few, often weakly organized convective cells.

Number of warning information sources and decision making during tornadoes.

PubMed

Luo, Jianjun; Cong, Zhen; Liang, Daan

2015-03-01

Taking proper protective action upon receiving tornado warnings is critical to reducing casualties. With more warning information sources becoming available, how the number of such information sources affects decision making should be quantitatively investigated. To examine how the number of warning information sources affected individuals' decisions to take protective action during tornadoes. A telephone survey using random sampling was conducted in 2012 with residents in Tuscaloosa AL and Joplin MO, resulting in a working sample of 782 respondents. Both cities were struck by violent tornadoes (Enhanced Fujita Scale [EF]4 and EF5) in 2011. The analysis was conducted in 2013. Logistic regression analysis showed that relative to having only one warning information source, having two and three or more warning information sources significantly increased the odds of taking protective action in Joplin but not in Tuscaloosa; having three or more sources had a significantly stronger effect on taking protective action in Joplin than in Tuscaloosa. Having an emergency preparation plan in both cities and being white in Tuscaloosa significantly increased the odds of taking protective action, whereas being divorced in Joplin reduced these odds. Receiving warnings from more warning information sources might be more beneficial in places with less previous exposure to tornadoes and for populations with lower awareness of a potential tornado and higher probability of receiving no warnings. Emergency management agencies and public health officials should give priority to these places and populations when formulating disaster mitigation decisions and policies. Copyright © 2015 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Focal Contacts as Mechanosensors

PubMed Central

Riveline, Daniel; Zamir, Eli; Balaban, Nathalie Q.; Schwarz, Ulrich S.; Ishizaki, Toshimasa; Narumiya, Shuh; Kam, Zvi; Geiger, Benjamin; Bershadsky, Alexander D.

2001-01-01

The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II–driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of focal contacts and to elucidate the role of cell contractility, we applied mechanical force to vinculin-containing dot-like adhesions at the cell edge using a micropipette. Local centripetal pulling led to local assembly and elongation of these structures and to their development into streak-like focal contacts, as revealed by the dynamics of green fluorescent protein–tagged vinculin or paxillin and interference reflection microscopy. Inhibition of Rho activity by C3 transferase suppressed this force-induced focal contact formation. However, constitutively active mutants of another Rho target, the formin homology protein mDia1 (Watanabe, N., T. Kato, A. Fujita, T. Ishizaki, and S. Narumiya. 1999. Nat. Cell Biol. 1:136–143), were sufficient to restore force-induced focal contact formation in C3 transferase-treated cells. Force-induced formation of the focal contacts still occurred in cells subjected to myosin II and ROCK inhibition. Thus, as long as mDia1 is active, external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts. Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force. PMID:11402062

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism.

PubMed

Riveline, D; Zamir, E; Balaban, N Q; Schwarz, U S; Ishizaki, T; Narumiya, S; Kam, Z; Geiger, B; Bershadsky, A D

2001-06-11

The transition of cell-matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II-driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of focal contacts and to elucidate the role of cell contractility, we applied mechanical force to vinculin-containing dot-like adhesions at the cell edge using a micropipette. Local centripetal pulling led to local assembly and elongation of these structures and to their development into streak-like focal contacts, as revealed by the dynamics of green fluorescent protein-tagged vinculin or paxillin and interference reflection microscopy. Inhibition of Rho activity by C3 transferase suppressed this force-induced focal contact formation. However, constitutively active mutants of another Rho target, the formin homology protein mDia1 (Watanabe, N., T. Kato, A. Fujita, T. Ishizaki, and S. Narumiya. 1999. Nat. Cell Biol. 1:136-143), were sufficient to restore force-induced focal contact formation in C3 transferase-treated cells. Force-induced formation of the focal contacts still occurred in cells subjected to myosin II and ROCK inhibition. Thus, as long as mDia1 is active, external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts. Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force.

An isolated tornadic supercell of 14 July 2012 in Poland - A prediction technique within the use of coarse-grid WRF simulation

NASA Astrophysics Data System (ADS)

Taszarek, Mateusz; Czernecki, Bartosz; Walczakiewicz, Szymon; Mazur, Andrzej; Kolendowicz, Leszek

2016-09-01

On 14 July 2012 a shortwave trough with a cold front passed through Poland. A few tornadoes were reported in the north central part of the country within an isolated cyclic supercell. The cell moved along the thermal and moisture horizontal gradients and the support of a synoptic scale lift. An analysis allowed for setting up four tornado damage tracks in a distance of 100 km and with a total length of 60 km. Tornadoes damaged 105 buildings with predominant intensity of F1-F2/T3-T4 (maximum F3/T6) in Fujita/TORRO scale, caused 1 fatality, 10 injures and felled 500 hectares of Bory Tucholskie forest. The main aim of this article was to analyze this event and assess the possibilities of its short-term prediction. In order to achieve this, a model forecast data derived from WRF-ARW simulation with a spatial resolution of 15 km and initial conditions extracted from 0000 UTC GFS was used. An analysis yielded that the cell moved in the environment of a low lifting condensation level, rich boundary layer's moisture content and a steepening vertical lapse rates that provided the presence of a thermodynamic instability. A wind vectors tilting with height and an increased vertical wind shear occurred as well. A forecasting method that combined a Universal Tornadic Index composite parameter with a convective precipitation filter showed that convective cells at 1500 UTC in the north central Poland had a potential to become tornadic. Within the use of a proposed methodology, it was possible to issue a tornado forecast for the areas where an index pointed the risk.

Estimating Price Elasticity using Market-Level Appliance Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujita, K. Sydny

This report provides and update to and expansion upon our 2008 LBNL report “An Analysis of the Price Elasticity of Demand for Appliances,” in which we estimated an average relative price elasticity of -0.34 for major household appliances (Dale and Fujita 2008). Consumer responsiveness to price change is a key component of energy efficiency policy analysis; these policies influence consumer purchases through price both explicitly and implicitly. However, few studies address appliance demand elasticity in the U.S. market and public data sources are generally insufficient for rigorous estimation. Therefore, analysts have relied on a small set of outdated papers focusedmore » on limited appliance types, assuming long-term elasticities estimated for other durables (e.g., vehicles) decades ago are applicable to current and future appliance purchasing behavior. We aim to partially rectify this problem in the context of appliance efficiency standards by revisiting our previous analysis, utilizing data released over the last ten years and identifying additional estimates of durable goods price elasticities in the literature. Reviewing the literature, we find the following ranges of market-level price elasticities: -0.14 to -0.42 for appliances; -0.30 to -1.28 for automobiles; -0.47 to -2.55 for other durable goods. Brand price elasticities are substantially higher for these product groups, with most estimates -2.0 or more elastic. Using market-level shipments, sales value, and efficiency level data for 1989-2009, we run various iterations of a log-log regression model, arriving at a recommended range of short run appliance price elasticity between -0.4 and -0.5, with a default value of -0.45.« less

Categorizing natural disaster damage assessment using satellite-based geospatial techniques

NASA Astrophysics Data System (ADS)

Myint, S. W.; Yuan, M.; Cerveny, R. S.; Giri, C.

2008-07-01

Remote sensing of a natural disaster's damage offers an exciting backup and/or alternative to traditional means of on-site damage assessment. Although necessary for complete assessment of damage areas, ground-based damage surveys conducted in the aftermath of natural hazard passage can sometimes be potentially complicated due to on-site difficulties (e.g., interaction with various authorities and emergency services) and hazards (e.g., downed power lines, gas lines, etc.), the need for rapid mobilization (particularly for remote locations), and the increasing cost of rapid physical transportation of manpower and equipment. Satellite image analysis, because of its global ubiquity, its ability for repeated independent analysis, and, as we demonstrate here, its ability to verify on-site damage assessment provides an interesting new perspective and investigative aide to researchers. Using one of the strongest tornado events in US history, the 3 May 1999 Oklahoma City Tornado, as a case example, we digitized the tornado damage path and co-registered the damage path using pre- and post-Landsat Thematic Mapper image data to perform a damage assessment. We employed several geospatial approaches, specifically the Getis index, Geary's C, and two lacunarity approaches to categorize damage characteristics according to the original Fujita tornado damage scale (F-scale). Our results indicate strong relationships between spatial indices computed within a local window and tornado F-scale damage categories identified through the ground survey. Consequently, linear regression models, even incorporating just a single band, appear effective in identifying F-scale damage categories using satellite imagery. This study demonstrates that satellite-based geospatial techniques can effectively add spatial perspectives to natural disaster damages, and in particular for this case study, tornado damages.

Comparative Analysis of the Regulation of Expression and Structures of Two Evolutionarily Divergent Genes for Δ1-Pyrroline-5-Carboxylate Synthetase from Tomato1

PubMed Central

Fujita, Tomomichi; Maggio, Albino; Garcia-Rios, Mario; Bressan, Ray A.; Csonka, Laszlo N.

1998-01-01

We isolated two tomato (Lycopersicon esculentum) cDNA clones, tomPRO1 and tomPRO2, specifying Δ1-pyrroline-5-carboxylate synthetase (P5CS), the first enzyme of proline (Pro) biosynthesis. tomPRO1 is unusual because it resembles prokaryotic polycistronic operons (M.G. García-Ríos, T. Fujita, P.C. LaRosa, R.D. Locy, J.M. Clithero, R.A. Bressan, L.N. Csonka [1997] Proc Natl Acad Sci USA 94: 8249–8254), whereas tomPRO2 encodes a full-length P5CS. We analyzed the accumulation of Pro and the tomPRO1 and tomPRO2 messages in response to NaCl stress and developmental signals. Treatment with 200 mm NaCl resulted in a >60-fold increase in Pro levels in roots and leaves. However, there was a <3-fold increase in the accumulation of the tomPRO2 message and no detectable induction in the level of the tomPRO1 message in response to NaCl stress. Although pollen contained approximately 100-fold higher levels of Pro than other plant tissues, there was no detectable increase in the level of either message in pollen. We conclude that transcriptional regulation of these genes for P5CS is probably not important for the osmotic or pollen-specific regulation of Pro synthesis in tomato. Using restriction fragment-length polymorphism mapping, we determined the locations of tomPRO1 and tomPRO2 loci in the tomato nuclear genome. Sequence comparison suggested that tomPRO1 is similar to prokaryotic P5CS loci, whereas tomPRO2 is closely related to other eukaryotic P5CS genes. PMID:9765552

Mass casualty following unprecedented tornadic events in the Southeast: natural disaster outcomes at a Level I trauma center.

PubMed

Hartmann, Elizabeth H; Creel, Nathan; Lepard, Jacob; Maxwell, Robert A

2012-07-01

On April 27, 2011, an EF4 (enhanced Fujita scale) tornado struck a 48-mile path across northwest Georgia and southeast Tennessee. Traumatic injuries sustained during this tornado and others in one of the largest tornado outbreaks in history presented to the regional Level I trauma center, Erlanger Health System, in Chattanooga, TN. Patients were triaged per mass casualty protocols through an incident command center and triage officer. Medical staffing was increased to anticipate a large patient load. Records of patients admitted as a result of tornado-related injury were retrospectively reviewed and characterized by the injury patterns, demographics, procedures performed, length of stay, and complications. One hundred four adult patients were treated in the emergency department; of these, 28 (27%) patients required admission to the trauma service. Of those admitted, 16 (57%) were male with an age range of 21 to 87 years old and an average length of stay of 10.9 ± 11.8 days. Eleven (39%) patients required intensive care unit admissions. The most common injuries seen were those of soft tissue, bony fractures, and the chest. Interventions included tube thoracostomies, exploratory laparotomies, orthopedic fixations, soft tissue reconstructions, and craniotomy. All 28 patients admitted survived to discharge. Nineteen (68%) patients were discharged home, six (21%) went to a rehabilitation hospital, and three (11%) were transferred to skilled nursing facilities. Emergency preparedness and organization are key elements in effectively treating victims of natural disasters. Those victims who survive the initial tornadic event and present to a Level I trauma center have low mortality. Like in our experience, triage protocols need to be implemented to quickly and effectively manage mass injuries.

Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.

PubMed

Hirata, Tetsuya; Fujita, Morihisa; Nakamura, Shota; Gotoh, Kazuyoshi; Motooka, Daisuke; Murakami, Yoshiko; Maeda, Yusuke; Kinoshita, Taroh

2015-09-01

The importance of endosome-to-trans-Golgi network (TGN) retrograde transport in the anterograde transport of proteins is unclear. In this study, genome-wide screening of the factors necessary for efficient anterograde protein transport in human haploid cells identified subunits of the Golgi-associated retrograde protein (GARP) complex, a tethering factor involved in endosome-to-TGN transport. Knockout (KO) of each of the four GARP subunits, VPS51-VPS54, in HEK293 cells caused severely defective anterograde transport of both glycosylphosphatidylinositol (GPI)-anchored and transmembrane proteins from the TGN. Overexpression of VAMP4, v-SNARE, in VPS54-KO cells partially restored not only endosome-to-TGN retrograde transport, but also anterograde transport of both GPI-anchored and transmembrane proteins. Further screening for genes whose overexpression normalized the VPS54-KO phenotype identified TMEM87A, encoding an uncharacterized Golgi-resident membrane protein. Overexpression of TMEM87A or its close homologue TMEM87B in VPS54-KO cells partially restored endosome-to-TGN retrograde transport and anterograde transport. Therefore GARP- and VAMP4-dependent endosome-to-TGN retrograde transport is required for recycling of molecules critical for efficient post-Golgi anterograde transport of cell-surface integral membrane proteins. In addition, TMEM87A and TMEM87B are involved in endosome-to-TGN retrograde transport. © 2015 Hirata, Fujita, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Efficacy and safety of febuxostat in elderly female patients.

PubMed

Mizuno, Tomohiro; Hayashi, Takahiro; Hikosaka, Sayo; Shimabukuro, Yuka; Murase, Maho; Takahashi, Kazuo; Hayashi, Hiroki; Yuzawa, Yukio; Nagamatsu, Tadashi; Yamada, Shigeki

2014-01-01

Maintenance of low serum urate levels is important for the management of gout. Achieving the recommended serum urate levels of less than 6.0 mg/dL is difficult in elderly (65 years of age or older) patients with renal impairment. Xanthine oxidase inhibitors allopurinol and febuxostat are used for this purpose. Although febuxostat had been shown to be efficacious in elderly patients, its safety and efficacy in elderly female patients with hyperuricemia remain unclear. The aim of this study was to assess the efficacy and safety of febuxostat in elderly female patients. We studied a retrospective cohort study. The study included elderly Japanese patients (65 years of age or older) who were treated with febuxostat at Fujita Health University Hospital from January 2012 to December 2013. The treatment goal was defined as achievement of serum urate levels of 6.0 mg/dL or lower within 16 weeks; this was the primary endpoint in the present study. Adverse events of febuxostat were defined as more than twofold increases in Common Terminology Criteria for adverse events scores from baseline. We evaluated 82 patients treated with febuxostat during the observation period and classified them into male (n=53) and female (n=29) groups. The mean time to achievement of the treatment goal was significantly shorter in the female group (53 days) than in the male group (71 days). There were no significant differences in adverse events between the 2 groups. Our findings suggest that the efficacy of febuxostat in elderly female patients is superior to that in elderly male patients and that the safety is equivalent.

Efficacy and safety of febuxostat in elderly female patients

PubMed Central

Mizuno, Tomohiro; Hayashi, Takahiro; Hikosaka, Sayo; Shimabukuro, Yuka; Murase, Maho; Takahashi, Kazuo; Hayashi, Hiroki; Yuzawa, Yukio; Nagamatsu, Tadashi; Yamada, Shigeki

2014-01-01

Background Maintenance of low serum urate levels is important for the management of gout. Achieving the recommended serum urate levels of less than 6.0 mg/dL is difficult in elderly (65 years of age or older) patients with renal impairment. Xanthine oxidase inhibitors allopurinol and febuxostat are used for this purpose. Although febuxostat had been shown to be efficacious in elderly patients, its safety and efficacy in elderly female patients with hyperuricemia remain unclear. Objective The aim of this study was to assess the efficacy and safety of febuxostat in elderly female patients. Methods We studied a retrospective cohort study. The study included elderly Japanese patients (65 years of age or older) who were treated with febuxostat at Fujita Health University Hospital from January 2012 to December 2013. The treatment goal was defined as achievement of serum urate levels of 6.0 mg/dL or lower within 16 weeks; this was the primary endpoint in the present study. Adverse events of febuxostat were defined as more than twofold increases in Common Terminology Criteria for adverse events scores from baseline. Results We evaluated 82 patients treated with febuxostat during the observation period and classified them into male (n=53) and female (n=29) groups. The mean time to achievement of the treatment goal was significantly shorter in the female group (53 days) than in the male group (71 days). There were no significant differences in adverse events between the 2 groups. Conclusion Our findings suggest that the efficacy of febuxostat in elderly female patients is superior to that in elderly male patients and that the safety is equivalent. PMID:25214776

Objective classification of historical tropical cyclone intensity

NASA Astrophysics Data System (ADS)

Chenoweth, Michael

2007-03-01

Preinstrumental records of historical tropical cyclone activity require objective methods for accurately categorizing tropical cyclone intensity. Here wind force terms and damage reports from newspaper accounts in the Lesser Antilles and Jamaica for the period 1795-1879 are compared with wind speed estimates calculated from barometric pressure data. A total of 95 separate barometric pressure readings and colocated simultaneous wind force descriptors and wind-induced damage reports are compared. The wind speed estimates from barometric pressure data are taken as the most reliable and serve as a standard to compare against other data. Wind-induced damage reports are used to produce an estimated wind speed range using a modified Fujita scale. Wind force terms are compared with the barometric pressure data to determine if a gale, as used in the contemporary newspapers, is consistent with the modern definition of a gale. Results indicate that the modern definition of a gale (the threshold point separating the classification of a tropical depression from a tropical storm) is equivalent to that in contemporary newspaper accounts. Barometric pressure values are consistent with both reported wind force terms and wind damage on land when the location, speed and direction of movement of the tropical cyclone are determined. Damage reports and derived wind force estimates are consistent with other published results. Biases in ships' logbooks are confirmed and wind force terms of gale strength or greater are identified. These results offer a bridge between the earlier noninstrumental records of tropical cyclones and modern records thereby offering a method of consistently classifying storms in the Caribbean region into tropical depressions, tropical storms, nonmajor and major hurricanes.

Categorizing natural disaster damage assessment using satellite-based geospatial techniques

USGS Publications Warehouse

Myint, S.W.; Yuan, M.; Cerveny, R.S.; Giri, C.

2008-01-01

Remote sensing of a natural disaster's damage offers an exciting backup and/or alternative to traditional means of on-site damage assessment. Although necessary for complete assessment of damage areas, ground-based damage surveys conducted in the aftermath of natural hazard passage can sometimes be potentially complicated due to on-site difficulties (e.g., interaction with various authorities and emergency services) and hazards (e.g., downed power lines, gas lines, etc.), the need for rapid mobilization (particularly for remote locations), and the increasing cost of rapid physical transportation of manpower and equipment. Satellite image analysis, because of its global ubiquity, its ability for repeated independent analysis, and, as we demonstrate here, its ability to verify on-site damage assessment provides an interesting new perspective and investigative aide to researchers. Using one of the strongest tornado events in US history, the 3 May 1999 Oklahoma City Tornado, as a case example, we digitized the tornado damage path and co-registered the damage path using pre- and post-Landsat Thematic Mapper image data to perform a damage assessment. We employed several geospatial approaches, specifically the Getis index, Geary's C, and two lacunarity approaches to categorize damage characteristics according to the original Fujita tornado damage scale (F-scale). Our results indicate strong relationships between spatial indices computed within a local window and tornado F-scale damage categories identified through the ground survey. Consequently, linear regression models, even incorporating just a single band, appear effective in identifying F-scale damage categories using satellite imagery. This study demonstrates that satellite-based geospatial techniques can effectively add spatial perspectives to natural disaster damages, and in particular for this case study, tornado damages.

Variability of back carbon in Northwest Greenland during the past 350 years

NASA Astrophysics Data System (ADS)

Goto-Azuma, Kumiko; Ogawa-Tsukagawa, Yoshimi; Kondo, Yutaka; Dallmayr, Remi; Hirabayashi, Motohiro; Ogata, Jun; Kitamura, Kyotaro; Kawamura, Kenji; Motoyama, Hideaki; Matoba, Sumito; Aoki, Teruo; Moteki, Nobuhiro; Ohata, Sho; Mori, Tatsuhiro; Koike, Makoto; Komuro, Yuki; Tsushima, Akane; Nagatsuka, Naoko

2017-04-01

An ice core to the depth of 225 m was drilled at the SIGMA-D site, Northwest Greenland, in 2014 under the SIGMA (Snow Impurity and Glacial Microbe Effects on Abrupt Warming in the Arctic) project (Matoba et al., 2015). The ice core was analyzed to the depth of 113 m with a Continuous Flow Analysis (CFA) system, which was recently built at the National Institute of Polar Research, Japan. The CFA system allowed high resolution analyses of black carbon (BC), stable isotopes of water, microparticles, electric conductivity, and trace elements (Na, K, Mg, Ca, Fe, and Al). BC was analyzed with a Wide Range SP2, which was recently developed by University of Tokyo (Mori et al., 2016). The Wide Range SP2 enabled us to measure BC particles with the size range between 40 and 4000 nm. Here we report the variability of BC concentrations and size distributions during the past 350 years. Anthropogenic impacts on concentrations, size distributions, and their seasonal variations were clearly seen during the first half of the 20th Century. References Matoba, S., H. Motoyama, K. Fujita. T. Yamasaki, M. Minowa, Y. Onuma Y. Komuro, T. Aoki, S. Yamaguchi, S. Sugiyama and H. Enomoto, Glaciological and meteorological observations at the SIGMA-D site, northwestern Greenland Ice Sheet. Bulletin of Glaciological Research 33, 7-10, 2015. Mori, T., N. Moteki, S. Ohata, M. Koike, K. Goto-Azuma, Y. Miyazaki and Y. Kondo, Improved technique for measuring the size distribution of black carbon particles in liquid water, Aerosol Science & Technology, 50, 3, 242-254, DOI: 10.1080/02786826.2016.1147644, 2016.

In situ speciation of uranium in treated acid mine drainage using the diffusion gradients in thin films technique (DGT).

PubMed

Pedrobom, Jorge Henrique; Eismann, Carlos Eduardo; Menegário, Amauri A; Galhardi, Juliana Aparecida; Luko, Karen Silva; Dourado, Thiago de Araujo; Kiang, Chang Hung

2017-02-01

The exchange membranes P81 and DE81 and Chelex-100 resin were used to perform in situ speciation of uranium in treated acid mine drainage at the Osamu Utsumi mining site, Poços de Caldas city, Southeast Brazil. To investigate possible chemical modifications in the samples during analysis, the three ligands were deployed in situ and in a laboratory (in lab). The results obtained in situ were also compared to a speciation performed using Visual MINTEQ software. Chelex-100 retained total labile U for a period of up to 48 h. The labile U fraction determined by Chelex 100 ranged from 107 ± 6% to 147 ± 44% in situ and from 115 ± 22% to 191 ± 5% in lab. DE81 retained anionic U species up to 8 h, with labile fractions ranging from 37 ± 2% to 76 ± 3% in situ and 34 ± 12% to 180 ± 17% in lab. P81 exhibited a lower efficiency in retaining U species, with concentrations ranging from 6± 2% to 19± 2% in situ and 3± 2% to 18± 2% in lab. The speciation obtained from MINTEQ suggests that the major U species were UO 2 OH + , UO 2 (OH) 3- , UO 2 (OH) 2(aq) , Ca 2 UO 2 (CO 3 ) 3(aq) , CaUO 2 (CO 3 ) 3 2- , UO 2 (CO 3 ) 2 2- , and UO 2 (CO 3 ) 3 4- . This result is in accordance with the results obtained in situ. Differences concerning speciation and the total and soluble U concentrations were observed between the deployments performed in situ and in the laboratory, indicating that U speciation must be performed in situ. Copyright © 2016 Elsevier Ltd. All rights reserved.

Dynamic weakening of smectite-rich faults at intermediate to high velocities

NASA Astrophysics Data System (ADS)

Oohashi, K.; Hirose, T.; Takahashi, M.

2013-12-01

Smectite, one of the hydrous clay mineral, is ubiquitous in incoming sediments to subduction zones and is thought to weaken and stabilize subduction thrust faults. However, frictional properties of smectite alone cannot explain the nucleation and propagation of earthquake slip at the shallow plate boundary thrust which potentially causes the devastating tsunamis. Here, we investigate for the first time the effect of smectite fraction in smectite-quartz mixtures on friction at 30 μm/s to 1.3 m/s, to shed a light on the frictional response for the intermediate to high slip rates where the conventional friction experiments have not been explored. In the low slip rate of 30 μm/s, the steady-state coefficient of friction decreases non-linearly increasing smectite fraction: it drops rapidly at moderate fraction of 30-50 vol%. On the other hand, at the faster slip rates of ≥ 150 μm/s the friction lowers from 10-20 vol% fraction since drastic slip weakening appears for the mixtures of ~20 vol % smectite. Hence the fault suddenly loses the strength by adding only 20 % of smectite. The weakening seems to be associated with an excess pore pressure invoked by shear compaction and thermal pressurization during the experiments. This property weakens the fault strength and accelerates the fault slip, even if clay content is small (c.a. 15-35 %), leading to the large stress drop. In contrast, the faults rich in smectite (≥ 50 %) may cause small stress drop during the faulting owing to low friction coefficient of smectite at any slip rates. The results highlight that smectite content significantly affects frictional properties of faults and may generates the diversity in the subduction zone earthquakes. ACKNOLEDGEMENTS We thank Kyuichi Kanagawa, Masaya Suzuki, Osamu Tadai, and Hiroko Kitajima for constructive discussions and technical help. This work was supported by a JSPS Grant-in-Aid for JSPS fellows (25-04960) to KO, a JSPS Grant-in-Aid for Young Scientists (B) (20740264

Approaches to Numerical Relativity

NASA Astrophysics Data System (ADS)

d'Inverno, Ray

2005-07-01

. Self-gravitating thin disks around rotating black holes A. Lanza; 24. An ADI and causal reconnection Gabrielle D. Allen and Bernard F. Schutz; 25. Time-symmetric ADI and causal reconnection Miguel Alcubierre and Bernard F. Schutz; 26. The numerical study of topological defects E. P. S. Shellard; 27. Computations of bubble growth during the cosmological quark-hadron transition J. C. Miller and O. Pantano; 28. Initial data of axisymmetric gravitational waves with a cosmological constant Ken-Ichi Nakao, Kei-Ichi Maeda, Takashi Nakamura and Ken-Ichi Oohara.

Effects of chiral three-nucleon forces on 4He-nucleus scattering in a wide range of incident energies

NASA Astrophysics Data System (ADS)

Toyokawa, Masakazu; Yahiro, Masanobu; Matsumoto, Takuma; Kohno, Michio

2018-02-01

An important current subject is to clarify the properties of chiral three-nucleon forces (3NFs) not only in nuclear matter but also in scattering between finite-size nuclei. Particularly for elastic scattering, this study has just started and the properties are not understood for a wide range of incident energies (E_in). We investigate basic properties of chiral 3NFs in nuclear matter with positive energies by using the Brueckner-Hartree-Fock method with chiral two-nucleon forces at N3LO and 3NFs at NNLO, and analyze the effects of chiral 3NFs on 4He elastic scattering from targets ^{208}Pb, ^{58}Ni, and ^{40}Ca over a wide range of 30 ≲ E_in/A_P ≲ 200 MeV by using the g-matrix folding model, where A_P is the mass number of the projectile. In symmetric nuclear matter with positive energies, chiral 3NFs make the single-particle potential less attractive and more absorptive. The effects mainly come from the Fujita-Miyazawa 2π-exchange 3NF and become slightly larger as E_in increases. These effects persist in the optical potentials of 4He scattering. As for the differential cross sections of 4He scattering, chiral-3NF effects are large for E_in/A_P ≳ 60 MeV and improve the agreement of the theoretical results with the measured ones. Particularly for E_in/A_P ≳ 100 MeV, the folding model reproduces measured differential cross sections pretty well. Cutoff (Λ) dependence is investigated for both nuclear matter and 4He scattering by considering two cases of Λ=450 and 550 MeV. The uncertainty coming from the dependence is smaller than chiral-3NF effects even at E_in/A_P=175 MeV.

A unified multicomponent stress-diffusion model of drug release from non-biodegradable polymeric matrix tablets.

PubMed

Salehi, Ali; Zhao, Jin; Cabelka, Tim D; Larson, Ronald G

2016-02-28

We propose a new transport model of drug release from hydrophilic polymeric matrices, based on Stefan-Maxwell flux laws for multicomponent transport. Polymer stress is incorporated in the total mixing free energy, which contributes directly to the diffusion driving force while leading to time-dependent boundary conditions at the tablet interface. Given that hydrated matrix tablets are dense multicomponent systems, extended Stefan-Maxwell (ESM) flux laws are adopted to ensure consistency with the Onsager reciprocity principle and the Gibbs-Duhem thermodynamic constraint. The ESM flux law for any given component takes into account the friction exerted by all other species and is invariant with respect to reference velocity, thus satisfying Galilean translational invariance. Our model demonstrates that penetrant-induced plasticization of polymer chains partially or even entirely offsets the steady decline of chemical potential gradients at the tablet-medium interface that drive drug release. Utilizing a Flory-Huggins thermodynamic model, a modified form of the upper convected Maxwell constitutive equation for polymer stress and a Fujita-type dependence of mutual diffusivities on composition, depending on parameters, Fickian, anomalous or case II drug transport arises naturally from the model, which are characterized by quasi-power-law release profiles with exponents ranging from 0.5 to 1, respectively. A necessary requirement for non-Fickian release in our model is that the matrix stress relaxation time is comparable to the time scale for water diffusion. Mutual diffusivities and their composition dependence are the most decisive factors in controlling drug release characteristics in our model. Regression of the experimental polymer dissolution and drug release profiles in a system of Theophylline/cellulose (K15M) demonstrate that API-water mutual diffusivity in the presence of excipient cannot generally be taken as a constant. Copyright © 2016 Elsevier B.V. All

Simulation of the Tornado Event of 22 March, 2013 over Brahmanbaria, Bangladesh using WRF Model with 3DVar DA techniques

NASA Astrophysics Data System (ADS)

Ahasan, M. N.; Alam, M. M.; Debsarma, S. K.

2015-02-01

A severe thunderstorm produced a tornado (F2 on the enhanced Fujita-Pearson scale), which affected the Brahmanbaria district of Bangladesh during 1100-1130 UTC of 22 March, 2013. The tornado consumed 38, injured 388 and caused a huge loss of property. The total length travelled by the tornado was about 12-15 km and about 1728 households were affected. An attempt has been made to simulate this rare event using the Weather Research and Forecasting (WRF) model. The model was run in a single domain at 9 km resolution for a period of 24 hrs, starting at 0000 UTC on 22 March, 2013. The meteorological conditions that led to form this tornado have been analyzed. The model simulated meteorological conditions are compared with that of a `no severe thunderstorm observed day' on 22 March, 2012. Thus, the model also ran in the same domain at same resolution for 24 hrs, starting at 0000 UTC on 22 March, 2012. The model simulated meteorological parameters are consistent with each other, and all are in good agreement with the observation in terms of the region of occurrence of the tornado activity. The model has efficiently captured the common favourable synoptic conditions for the occurrence of severe tornadoes though there are some spatial and temporal biases in the simulation. The wind speed is not in good agreement with the observation as it has shown the strongest wind of only 15-20 ms-1, against the estimated wind speed of about 55 ms-1. The spatial distributions as well as intensity of rainfall are also in good agreement with the observation. The results of these analyses demonstrated the capability of high-resolution WRF model with 3DVar Data Assimilation (DA) techniques in simulation of tornado over Brahmanbaria, Bangladesh.

Tornado-related fatalities--five states, Southeastern United States, April 25-28, 2011.

PubMed

2012-07-20

During April 25-28, 2011, a massive storm system generated 351 tornadoes (including 15 registering 4 or 5 on the Enhanced Fujita [EF] scale*), killing 338 persons in Alabama, Arkansas, Georgia, Mississippi, and Tennessee. This was the third-deadliest tornado event in the United States, surpassing an April 1974 event that resulted in 315 fatalities. This event also was historic because of the record number of fatalities that occurred despite modern advances in tornado forecasting, advanced warning times, and media coverage. Risk factors for death and injury from tornadoes are sheltering in mobile homes, proximity to an EF-4 or EF-5 tornado, being an older adult (aged ≥65 years), lack of accessibility to safe rooms (e.g., basements or reinforced shelters), and a night-time tornado impact. To describe the fatalities by demographic characteristics, type of shelter used, cause of death, and tornado severity and location, CDC reviewed data from the American Red Cross (Red Cross), death certificates, and the National Weather Service (NWS). This report summarizes the results of that review. Among the 338 decedents, median age was 55.0 years (range: 4 days-97 years); approximately one third were older adults. On tornado impact, 46.7% of decedents were in single-family homes, and 26.6% were in mobile homes. The leading cause of death was traumatic injury, including 21.9% with head injuries. Half of the deadly tornadoes were rated EF-4 or EF-5 and were responsible for 89.5% of the deaths. To prevent tornado-related deaths, health messaging should encourage the public (especially older adults and residents of mobile/manufactured homes) to pre-identify an accessible safe room, prepare the room with personal protection items (e.g., blankets and helmets), and monitor local weather.

Development of a Probabilistic Tornado Wind Hazard Model for the Continental United States Volume I: Main Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boissonnade, A; Hossain, Q; Kimball, J

Since the mid-l980's, assessment of the wind and tornado risks at the Department of Energy (DOE) high and moderate hazard facilities has been based on the straight wind/tornado hazard curves given in UCRL-53526 (Coats, 1985). These curves were developed using a methodology that utilized a model, developed by McDonald, for severe winds at sub-tornado wind speeds and a separate model, developed by Fujita, for tornado wind speeds. For DOE sites not covered in UCRL-53526, wind and tornado hazard assessments are based on the criteria outlined in DOE-STD-1023-95 (DOE, 1996), utilizing the methodology in UCRL-53526; Subsequent to the publication of UCRL53526,more » in a study sponsored by the Nuclear Regulatory Commission (NRC), the Pacific Northwest Laboratory developed tornado wind hazard curves for the contiguous United States, NUREG/CR-4461 (Ramsdell, 1986). Because of the different modeling assumptions and underlying data used to develop the tornado wind information, the wind speeds at specified exceedance levels, at a given location, based on the methodology in UCRL-53526, are different than those based on the methodology in NUREG/CR-4461. In 1997, Lawrence Livermore National Laboratory (LLNL) was funded by the DOE to review the current methodologies for characterizing tornado wind hazards and to develop a state-of-the-art wind/tornado characterization methodology based on probabilistic hazard assessment techniques and current historical wind data. This report describes the process of developing the methodology and the database of relevant tornado information needed to implement the methodology. It also presents the tornado wind hazard curves obtained from the application of the method to DOE sites throughout the contiguous United States.« less

Dual-Polarimetric Radar-Based Tornado Debris Signatures and Paths Associated with Tornadoes Over Northern Alabama During the Historic Outbreak of 27 April 2011

NASA Technical Reports Server (NTRS)

Carey, Lawrence D.; Schultz, Christopher J.; Schultz, Elise V.; Petersen, Walter A.; Gatlin, Patrick N.; Knupp, Kevin R.; Molthan, Andrew L.; Jedloved, Gary J.; Carcione, Brian C.; Darden, Christopher B.;

Simulation of Tornado over Brahmanbaria on 22 March 2013 using Doppler Weather Radar and WRF Model

NASA Astrophysics Data System (ADS)

Das, M. K.; Chowdhury, M.; Das, S.

2013-12-01

A tornado accompanied with thunderstorm, rainfall and hailstorm affected Brahmanbaria of Bangladesh in the afternoon of 22 March 2013. The tornadic storms are studied based on field survey, ground and radar observations. Low level moisture influx by southerly flow from the Bay of Bengal coupled with upper level westerly jet stream causing intense instability and shear in the wind fields triggered a series of storms for the day. The exact time and locations of the storms are investigated by using the Agartala and Cox's Bazar Doppler Weather Radar (DWR). Subsequently, the storms are simulated by using the WRF-ARW model at 1 km horizontal resolution based on 6 hourly analyses and boundary conditions of NCEP-FNL. Among the typical characteristics of the storms, the CAPE, surface wind speed, flow patterns, T-Φ gram, rainfall, sea level pressure, vorticity and vertical velocity are studied. Results show that while there are differences of 2-3 hours between the observed and simulated time of the storms, the distances between observed and simulated locations of the storms are several tens of kilometers. The maximum CAPE was generally above 2400 J kg-1 in the case. The maximum intensity of surface wind speed simulated by the model was only 38 m sec-1. This seems to be underestimated. The highest vertical velocity (updraft) simulated by the model was 250 m sec-1 around 800-950 hPa. The updraft reached up to 150 hPa. It seems that the funnel vortex reached the ground, and might have passed some places a few meters above the surface. According to the Fujita Pearson scale, this tornado can be classified as F-2 with estimated wind speed of 50-70 ms-1. Keywords: Tornado, DWR, NCEP-FNL, T-Φ gram, CAPE.

Monitoring Sound To Quantify Snoring and Sleep Apnea Severity Using a Smartphone: Proof of Concept

PubMed Central

Nakano, Hiroshi; Hirayama, Kenji; Sadamitsu, Yumiko; Toshimitsu, Ayaka; Fujita, Hisayuki; Shin, Shizue; Tanigawa, Takeshi

2014-01-01

Study Objectives: Habitual snoring is a prevalent condition that is not only a marker of obstructive sleep apnea (OSA) but can also lead to vascular risk. However, it is not easy to check snoring status at home. We attempted to develop a snoring sound monitor consisting of a smartphone alone, which is aimed to quantify snoring and OSA severity. Methods: The subjects included 50 patients who underwent diagnostic polysomnography (PSG), of which the data of 10 patients were used for developing the program and that of 40 patients were used for validating the program. A smartphone was attached to the anterior chest wall over the sternum. It acquired ambient sound from the built-in microphone and analyzed it using a fast Fourier transform on a real-time basis. Results: Snoring time measured by the smartphone highly correlated with snoring time measured by PSG (r = 0.93). The top 1 percentile value of sound pressure level (L1) determined by the smartphone correlated with the ambient sound L1 during sleep determined by PSG (r = 0.92). Moreover, the respiratory disturbance index estimated by the smartphone (smart-RDI) highly correlated with the apnea-hypopnea index (AHI) obtained by PSG (r = 0.94). The diagnostic sensitivity and specificity of the smart-RDI for diagnosing OSA (AHI ≥ 15) were 0.70 and 0.94, respectively. Conclusions: A smartphone can be used for effectively monitoring snoring and OSA in a controlled laboratory setting. Use of this technology in a noisy home environment remains unproven, and further investigation is needed. Commentary: A commentary on this article appears in this issue on page 79. Citation: Nakano H; Hirayama K; Sadamitsu Y; Toshimitsu A; Fujita H; Shin S; Tanigawa T. Monitoring sound to quantify snoring and sleep apnea severity using a smartphone: proof of concept. J Clin Sleep Med 2014;10(1):73-78. PMID:24426823

Influences of Fascicle Length During Isometric Training on Improvement of Muscle Strength.

PubMed

Tanaka, Hiroki; Ikezoe, Tome; Umehara, Jun; Nakamura, Masatoshi; Umegaki, Hiroki; Kobayashi, Takuya; Nishishita, Satoru; Fujita, Kosuke; Araki, Kojiro; Ichihashi, Noriaki

2016-11-01

Tanaka, H, Ikezoe, T, Umehara, J, Nakamura, M, Umegaki, H, Kobayashi, T, Nishishita, S, Fujita, K, Araki, K, and Ichihashi, N. Influences of fascicle length during isometric training on improvement of muscle strength. J Strength Cond Res 30(11): 3249-3255, 2016-This study investigated whether low-intensity isometric training would elicit a greater improvement in maximum voluntary contraction (MVC) at the same fascicle length, rather than the joint angle, adopted during training. Sixteen healthy women (21.8 ± 1.5 years) were randomly divided into an intervention group and a control group. Before (Pre) and after (Post) training, isometric plantarflexion MVCs were measured every 10° through the range of ankle joint position from 20° dorsiflexion to 30° plantarflexion (i.e., 6 ankle angles). Medial gastrocnemius fascicle length was also measured at each position, using B-mode ultrasound under 3 conditions of muscle activation: at rest, 30%MVC at respective angles, and MVC. Plantarflexion resistance training at an angle of 20° plantarflexion was performed 3 days a week for 4 weeks at 30%MVC using 3 sets of twenty 3-second isometric contractions. Maximum voluntary contraction in the intervention group increased at 0 and 10° plantarflexion (0°; Pre: 81.2 ± 26.5 N·m, Post: 105.0 ± 21.6 N·m, 10°; Pre: 63.0 ± 23.6 N·m, Post: 81.3 ± 20.3 N·m), which was not the angle used in training (20°). However, the fascicle length adopted in training at 20° plantarflexion and 30%MVC was similar to the value at 0 or 10° plantarflexion at MVC. Low-intensity isometric training at a shortened muscle length may be effective for improving MVC at a lengthened muscle length because of specificity of the fascicle length than the joint angle.

Thymectomy via a subxiphoid approach: single-port and robot-assisted

PubMed Central

Kaneda, Shinji; Hachimaru, Ayumi; Tochii, Daisuke; Maeda, Ryo; Tochii, Sachiko; Takagi, Yasushi

2016-01-01

Background We have previously reported on single-port thymectomy (SPT), which involves performing thymectomy via a single subxiphoid incision, and trans-subxiphoid robotic thymectomy (TRT), which is performed using the da Vinci surgical system. The aim of this study was to investigate the early surgical outcomes of thymectomy using the SPT and TRT subxiphoid approaches and to discuss their appropriate uses. Methods The subjects included 80 patients who underwent thymectomy via a subxiphoid approach. These patients were selected from among 99 surgical cases of myasthenia gravis or anterior mediastinal tumors at Fujita Health University Hospital between March 2011 and November 2015. The patients were divided into a SPT group (n=72) and a TRT group (n=8). Results The operative time was shorter in the SPT group compared with that in the TRT group (135±48 and 20±40 min, respectively; P=0.0004). There were no significant differences between the groups in terms of blood loss volume (5.9±16.8 and 5.4±4.6 mL, respectively; P=0.48), postoperative hospital stay duration (4.0±2.0 and 4.3±3.6 days, respectively; P=0.21), or the period of postoperative oral analgesic use (10.7±5.4 and 10.1±3.4 days, respectively; P=0.89). There were no intraoperative complications, such as intraoperative bleeding, in either group. In the SPT group, there was one case (1.4%) of postoperative left phrenic nerve paralysis and one case (1.4%) of transient paroxysmal atrial fibrillation. No one died during or after the surgery. Conclusions TRT may be as equally minimally invasive as SPT. In cases where the thymoma has infiltrated the surrounding organs, the extent of the infiltration should be used to determine whether to select TRT, or median sternotomy. PMID:27014473

Lessons Learned in the Integration of Earth Remote Sensing Data within the NOAA/NWS Damage Assessment Toolkit

NASA Astrophysics Data System (ADS)

Molthan, A.; Schultz, L. A.; McGrath, K.; Bell, J. R.; Cole, T.; Meyer, P. J.; Burks, J.; Camp, P.; Angle, K.

2016-12-01

Following the occurrence of a suspected or known tornado, meteorologists with NOAA's National Weather Service are tasked with performing a detailed ground survey to map the impacts of the tornado, identify specific damage indicators, and link those damage indicators to the Enhanced Fujita scale as an estimate of the intensity of the tornado at various points along the damage path. Over the past few years, NOAA/NWS meteorologists have developed the NOAA/NWS Damage Assessment Toolkit (DAT), a smartphone and web based application to support the collection of damage information, editing of the damage survey, and final publication. This allows meteorologists in the field to sample the damage track, collect geotagged photos with notations of damage areas, and aggregation of the information to provide a more detailed survey whereas previous efforts may have been limited to start and end locations, maximum width, and maximum intensity. To support these damage assessment efforts, various Earth remote sensing data sets were incorporated into the DAT to support survey efforts, following preliminary activities using remote sensing to support select NOAA/NWS field offices following the widespread outbreak of tornadoes that occurred in the southeastern United States on April 27, 2011. These efforts included the collection of various products in collaboration with multiple federal agencies and commercial providers, with particular emphasis upon the USGS Hazards Data Distribution System, hosting and sharing of these products through geospatial platforms, partnerships with forecasters to better understand their needs, and the development and delivery of training materials. This presentation will provide an overview of the project along with strengths and weaknesses, opportunities for future work and improvements, and best practices learned during the "research to applications" process supported by the NASA Applied Sciences: Disasters program.

Estimating flood discharge using witness movies in post-flood hydrological surveys

NASA Astrophysics Data System (ADS)

Le Coz, Jérôme; Hauet, Alexandre; Le Boursicaud, Raphaël; Pénard, Lionel; Bonnifait, Laurent; Dramais, Guillaume; Thollet, Fabien; Braud, Isabelle

2015-04-01

The estimation of streamflow rates based on post-flood surveys is of paramount importance for the investigation of extreme hydrological events. Major uncertainties usually arise from the absence of information on the flow velocities and from the limited spatio-temporal resolution of such surveys. Nowadays, after each flood occuring in populated areas home movies taken from bridges, river banks or even drones are shared by witnesses through Internet platforms like YouTube. Provided that some topography data and additional information are collected, image-based velocimetry techniques can be applied to some of these movie materials, in order to estimate flood discharges. As a contribution to recent post-flood surveys conducted in France, we developed and applied a method for estimating velocities and discharges based on the Large Scale Particle Image Velocimetry (LSPIV) technique. Since the seminal work of Fujita et al. (1998), LSPIV applications to river flows were reported by a number of authors and LSPIV can now be considered a mature technique. However, its application to non-professional movies taken by flood witnesses remains challenging and required some practical developments. The different steps to apply LSPIV analysis to a flood home movie are as follows: (i) select a video of interest; (ii) contact the author for agreement and extra information; (iii) conduct a field topography campaign to georeference Ground Control Points (GCPs), water level and cross-sectional profiles; (iv) preprocess the video before LSPIV analysis: correct lens distortion, align the images, etc.; (v) orthorectify the images to correct perspective effects and know the physical size of pixels; (vi) proceed with the LSPIV analysis to compute the surface velocity field; and (vii) compute discharge according to a user-defined velocity coefficient. Two case studies in French mountainous rivers during extreme floods are presented. The movies were collected on YouTube and field topography

Dual-Polarimetric Radar-Based Tornado Debris Paths Associated with EF-4 and EF-5 Tornadoes over Northern Alabama During the Historic Outbreak of 27 April 2011

NASA Technical Reports Server (NTRS)

Carey, Lawrence D.; Schultz, Christopher J.; Schultz, Elise V.; Petersen, Walter A.; Gatlin, Patrick N.; Knupp, Kevin R.; Molthan, Andrew L.; Darden, Christopher B.

2011-01-01

An historic tornado and severe weather outbreak devastated much of the southeastern United States between 25 and 28 April 2011. On 27 April 2011, northern Alabama was particularly hard hit by a large number of tornadoes, including several that reached EF-4 and EF-5 on the Enhanced Fujita damage scale. In northern Alabama alone, there were approximately 100 fatalities and hundreds of more people who were injured or lost their homes during the havoc caused by these violent tornadic storms. Two long-track and violent (EF-4 and EF-5) tornadoes occurred within range of the University of Alabama in Huntsville (UAHuntsville) Advanced Radar for Meteorological and Operational Research (ARMOR, C-band dual-polarimetric). A unique capability of dual-polarimetric radar is the near-real time identification of lofted debris associated with ongoing tornadoes on the ground. The focus of this paper is to analyze the dual-polarimetric radar-inferred tornado debris signatures and identify the associated debris paths of the long-track EF-4 and EF-5 tornadoes near ARMOR. The relative locations of the debris and damage paths for each tornado will be ascertained by careful comparison of the ARMOR analysis with NASA MODIS (Moderate Resolution Imaging Spectroradiometer) and ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) satellite imagery of the tornado damage scenes and the National Weather Service tornado damage surveys. With the ongoing upgrade of the WSR-88D (Weather Surveillance Radar - 1988 Doppler) operational network to dual-polarimetry and a similar process having already taken place or ongoing for many private sector radars, dual-polarimetric radar signatures of tornado debris promise the potential to assist in the situational awareness of government and private sector forecasters and emergency managers during tornadic events. As such, a companion abstract (Schultz et al.) also submitted to this conference explores "The use of dual-polarimetric tornadic

An Analysis of Operational Total Lightning Data During Long-Track Tornadoes

NASA Technical Reports Server (NTRS)

Carcione, Brian C.; Stano, Geoffrey T.

2012-01-01

The 27 April 2011 tornado outbreak brought three distinct waves of tornadic thunderstorms to portions of Mississippi, Alabama, Tennessee, and Georgia, striking the Tennessee Valley of north Alabama and southern Tennessee particularly hard. A total of 42 tornado paths were surveyed across the fourteen county area covered by the National Weather Service (NWS) forecast office in Huntsville, Alabama. Ten of these tornadoes were on the ground for at least 20 miles, two had total path lengths over 130 miles, and six tornadoes were classified as violent (EF-4 or EF-5 on the Enhanced Fujita Scale). Many of these tornadoes occurred within the domain of the North Alabama Lightning Mapping Array (NALMA), a ground-based total lightning detection network owned and operated by the NASA Marshall Space Flight Center. Since 2003, the NASA Short-term Prediction Research and Transition Center has supplied data from NALMA in real time to NWS forecast offices in Huntsville, Knoxville/Tri-Cities, Birmingham, and Nashville. Previous research has documented the utility of total lightning information in predicting tornadogenesis, particularly when combined with other remote sensing tools. Basic warning decision-making during events such as 27 April is not the most difficult part of the process; instead, the focus of warning meteorologists shifts to looking for changes in intensity or possible particularly dangerous situations, since doppler radar velocity data often cannot distinguish between weak and strong tornadoes. To that end, this research attempts to determine if any correlation exists between flash densities of the longest-tracked tornadoes over time, and the surveyed wind speeds of the tornadoes. The long-track EF-5 tornado which struck the Hackleburg, Phil Campbell, and Tanner communities in north Alabama was the primary focus of this research due to its intensity and extended life cycle. However, not all tornadoes were available for total lightning analysis due to widespread

Pattern and spectrum of tornado injury and its geographical information system distribution in Yancheng, China: a cross-sectional study.

PubMed

Deng, Qiangyu; Lv, Yipeng; Xue, Chen; Kang, Peng; Dong, Junqiang; Zhang, Lulu

2018-06-22

Few studies of tornado injuries have considered differences related to damage levels and Enhanced-Fujita (EF) scale ratings. This study aimed to evaluate the pattern, spectrum and geographical distribution of injuries related to the Yancheng tornado and provide guidelines for effective emergency medical strategies. The study was conducted at three hospitals which treated patients with injuries related to the tornado in Yancheng, China. We obtained the records of 451 patients with tornado-related injuries. Of these, 401 valid trauma medical records were included; 50 other records were excluded for insufficient information. Informed consent was obtained from all patients by telephone. We analysed patients' injury sites and types and used the abbreviated injury scale (AIS) to standardise injury severity. Geographical information system and non-parametric tests were used to analyse the effects of geographical factors on casualties. Women, middle-aged/elderly individuals (age>45 years) and children/adolescents (<18 years) accounted for 51.62%, 77.30% and 12.47% of injured patients, respectively. This caused a dumbbell-shaped age distribution. Head (46.63%), body surface (39.90%) and lower-limb (29.43%) injuries were common, as were soft-tissue injuries (90.77%), fractures (38.90%) and organ damage (19.70%). Minor injuries (AIS=1) were common (60.85%), whereas critical/fatal injuries (AIS≥5) were very rare (2.50%). Although the densities of injury varied among damage levels and EF ratings for different areas, area-wise differences in injury severity (AIS scores) were not significant (p>0.05). We recommend the use of helmets to prevent head injuries caused by tornadoes and suggest prioritising the treatment of high-risk head and multiple-organ injuries. Additionally, medical rescuers should follow the 'same quality and different quantity' principle: the injured in all affected areas should receive equal attention, but numbers of medical personnel should be allocated

Dual-Polarimetric Radar-Based Tornado Debris Paths Associated with EF-4 and EF-5 Tornadoes over Northern Alabama During the Historic Outbreak of 27 April 2011

NASA Technical Reports Server (NTRS)

Carey, Lawrence D.; Schultz, Chrstopher J.; Schultz, Elise V.; Petersen, Walter A.; Gatlin, Patrick N.; Knupp, Kevin R.; Molthan, Andrew L.; Jedlovec, Gary J.; Darden, Christopher B.

2012-01-01

An historic tornado and severe weather outbreak devastated much of the southeastern United States between 25 and 28 April 2011. On 27 April 2011, northern Alabama was particularly hard hit by a large number of tornadoes, including several that reached EF-4 and EF-5 on the Enhanced Fujita damage scale. In northern Alabama alone, there were approximately 100 fatalities and hundreds of more people who were injured or lost their homes during the havoc caused by these violent tornadic storms. Two long-track and violent (EF-4 and EF-5) tornadoes occurred within range of the University of Alabama in Huntsville (UAHuntsville) Advanced Radar for Meteorological and Operational Research (ARMOR, C-band dual-polarimetric). A unique capability of dual-polarimetric radar is the near-real time identification of lofted debris associated with ongoing tornadoes on the ground. The focus of this paper is to analyze the dual-polarimetric radar-inferred tornado debris signatures and identify the associated debris paths of the long-track EF-4 and EF-5 tornadoes near ARMOR. The relative locations of the debris and damage paths for each tornado will be ascertained by careful comparison of the ARMOR analysis with NASA MODIS (Moderate Resolution Imaging Spectroradiometer) and ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) satellite imagery of the tornado damage scenes and the National Weather Service tornado damage surveys. With the ongoing upgrade of the WSR-88D (Weather Surveillance Radar 1988 Doppler) operational network to dual-polarimetry and a similar process having already taken place or ongoing for many private sector radars, dual-polarimetric radar signatures of tornado debris promise the potential to assist in the situational awareness of government and private sector forecasters and emergency managers during tornadic events. As such, a companion abstract (Schultz et al.) also submitted to this conference explores The use of dual-polarimetric tornadic debris

Testing the Feasibility and Usability of a Novel Smartphone-Based Self-Management Support System for Dialysis Patients: A Pilot Study.

PubMed

Hayashi, Aki; Yamaguchi, Satoko; Waki, Kayo; Fujiu, Katsuhito; Hanafusa, Norio; Nishi, Takahiro; Tomita, Hyoe; Kobayashi, Haruka; Fujita, Hideo; Kadowaki, Takashi; Nangaku, Masaomi; Ohe, Kazuhiko

2017-04-20

Diet and fluid restrictions that need continuous self-management are among the most difficult aspects of dialysis treatment. Smartphone applications may be useful for supporting self-management. Our objective is to investigate the feasibility and usability of a novel smartphone-based self-management support system for dialysis patients. We developed the Self-Management and Recording System for Dialysis (SMART-D), which supports self-monitoring of three mortality-related factors that can be modified by lifestyle: interdialytic weight gain and predialysis serum potassium and phosphorus concentrations. Data is displayed graphically, with all data evaluated automatically to determine whether they achieve the values suggested by the Japanese Society for Dialysis Therapy guidelines. In a pilot study, 9 dialysis patients used SMART-D system for 2 weeks. A total of 7 of them completed questionnaires rating their assessment of SMART-D's usability and their satisfaction with the system. In addition, the Kidney Disease Quality of Life scale was compared before and after the study period. All 9 participants were able to use SMART-D with no major problems. Completion rates for body weight, pre- and postdialysis weight, and serum potassium and phosphorus concentrations were, respectively, 89% (SD 23), 95% (SD 7), and 78% (SD 44). Of the 7 participants who completed the usability survey, all were motivated by the sense of security derived from using the system, and 6 of the 7 (86%) reported that using SMART-D helped improve their lifestyle and self-management. Using SMART-D was feasible, and the system was well regarded by patients. Further study with larger scale cohorts and longer study and follow-up periods is needed to evaluate the effects of SMART-D on clinical outcomes and quality of life. ©Aki Hayashi, Satoko Yamaguchi, Kayo Waki, Katsuhito Fujiu, Norio Hanafusa, Takahiro Nishi, Hyoe Tomita, Haruka Kobayashi, Hideo Fujita, Takashi Kadowaki, Masaomi Nangaku, Kazuhiko Ohe

Post-embryonic development of Camallanus cotti (Nematoda: Camallanidae), with emphasis on growth of some taxonomically important somatic characters.

PubMed

Levsen, Arne; Berland, Bjørn

2002-01-01

In this paper, the quantitative post-embryonic development of the Asian freshwater fish nematode Camallanus cotti Fujita, 1927, is described. Larval and adult morphometrics were obtained by following the parasite's life cycle experimentally using copepods Macrocyclops albidus (Jurine) as intermediate host and guppies Poecilia reticulata (Peters), southern platyfish Xiphophorus maculatus (Günther) and paradise fish Macropodus opercularis (L.) as definitive host. Additionally, adult worms were obtained from heavily infected paradise fish imported from Singapore. It is suggested that the gradual change in proportions of the worm's somatic body parts reflects the specific ecological role of each developmental stage. The free-living infective first-stage larva seems to be adapted for transmission, as indicated by its relatively long tail, designed to generate host-attracting movements, and its non-functional intestine. The second- and third-stage larvae from the copepod intermediate host seem mainly to invest in trophic functionality, i.e., the development of the buccal capsule and the oesophagus, which are crucial structures for the worm's successful establishment in the definitive fish host. Once in the fish intestine, the larvae enter a period of considerable growth. After the fourth (i.e., last) moult, a 72% increase in average female body length occurs. This is accompanied by doubling the average vulva-tail tip distance and the average tail length. The length of the female hind body expands in an accelerating allometric fashion, and seems to be closely linked to the posterior-wards expansion of the uterus. In the males however, growth seems to cease after the final moult. We conclude that female post-maturational body size, but especially the length of the hind body and the tail, are closely related to reproductive state, i.e., the developmental stage of the offspring in the uterus, and, probably, the worms' age. Any future taxonomical studies of camallanids in

Addressing the human resources crisis: a case study of Cambodia’s efforts to reduce maternal mortality (1980–2012)

PubMed Central

Fujita, Noriko; Abe, Kimiko; Rotem, Arie; Tung, Rathavy; Keat, Phuong; Robins, Ann; Zwi, Anthony B

2013-01-01

Objective To identify factors that have contributed to the systematic development of the Cambodian human resources for health (HRH) system with a focus on midwifery services in response to high maternal mortality in fragile resource-constrained countries. Design Qualitative case study. Review of the published and grey literature and in-depth interviews with key informants and stakeholders using an HRH system conceptual framework developed by the authors (‘House Model’; Fujita et al, 2011). Interviews focused on the perceptions of respondents regarding their contributions to strengthening midwifery services and the other external influences which may have influenced the HRH system and reduction in the maternal mortality ratio (MMR). Setting Three rounds of interviews were conducted with senior and mid-level managers of the Ministries of Health (MoH) and Education, educational institutes and development partners. Participants A total of 49 interviewees, who were identified through a snowball sampling technique. Main outcome measures Scaling up the availability of 24 h maternal health services at all health centres contributing to MMR reduction. Results The incremental development of the Cambodian HRH system since 2005 focused on the production, deployment and retention of midwives in rural areas as part of a systematic strategy to reduce maternal mortality. The improved availability and access to midwifery services contributed to significant MMR reduction. Other contributing factors included improved mechanisms for decision-making and implementation; political commitment backed up with necessary resources; leadership from the top along with a growing capacity of mid-level managers; increased MoH capacity to plan and coordinate; and supportive development partners in the context of a conducive external environment. Conclusions Lessons from this case study point to the importance of a systemic and comprehensive approach to health and HRH system strengthening and

Using Satellite Remote Sensing to assist the National Weather Service (NWS) in Storm Damage Surveys

NASA Astrophysics Data System (ADS)

Schultz, L. A.; Molthan, A.; McGrath, K.; Bell, J. R.; Cole, T.; Burks, J.

2016-12-01

In recent years, the NWS has developed a GIS-based application, called the Damage Assessment Toolkit (DAT), to conduct storm surveys after severe weather events. At present, the toolkit is primarily used for tornado damage surveys and facilitates the identification of damage indicators in accordance with the Enhanced Fujita (EF) intensity scale by allowing surveyors to compare time- and geo-tagged photos against the EF scale guidelines. Mobile and web-based applications provide easy access to the DAT for NWS personnel while performing their duties in the field or office. Multispectral satellite remote sensing imagery has demonstrated benefits for the detection and mapping of damage tracks caused by tornadoes, especially for long-track events and/or areas not easily accessed by NWS personnel. For example, imagery from MODIS, Landsat 7, Landsat 8, ASTER, Sentinel 2, and commercial satellites, collected and distributed in collaboration with the USGS Hazards Data Distribution System, have been useful for refining track location and extent through a "bird's eye" view of the damaged areas. The NASA Short-term Prediction Research and Transition (SPoRT) Center has been working with the NWS and USGS to provide imagery and derived products from polar-orbiting satellite platforms to assist in the detection and refinement of tornado tracks as part of a NASA Applied Science: Disasters project. Working closely with select Weather Forecast Offices (WFOs) and Regional Operations Centers (ROCs) in both the NWS Central and Southern regions, high- and medium-resolution (0.5 - 30 m and 250 m - 1 km resolutions, respectively) imagery and derived products have been provided to the DAT interface for evaluation of operational utility by the NWS for their use in both the field and in the office during post event analysis. Highlighted in this presentation will be case studies where the remotely sensed imagery assisted in the adjustment of a tornado track. Examples will be shown highlighting

Cocowood Fibrovascular Tissue System—Another Wonder of Plant Evolution

PubMed Central

González, Oswaldo M.; Nguyen, Khoi A.

2016-01-01

The coconut palm (Cocos nucifera L.) stem tissue (referred to as cocowood in this study) is a complex fibrovascular system that is made up of fibrovascular bundles embedded into a parenchymatous ground tissue. The complex configuration of fibrovascular bundles along with the non-uniform distribution of the material properties likely allow senile coconut stems to optimize their biomechanical performance per unit mass (i.e., mechanical efficiency) and grow into tall, slender, and very flexible plants with minimum resources of biomass and water. For the first time, to the best of the authors' knowledge, this paper examines, from the integral (i.e., stem structure) and macroscopic (i.e., tissue structure) levels of hierarchy, the characteristic triple helix formation depicted by the fibrovascular bundles within the monocotyledon cocowood. The natural course of the tangential orientation of the axial fibrovascular bundles is mapped for the whole cocowood structure by quantifying 264 cocowood discs, corresponding to 41 senile coconut palms estimated to be >70 years old. The observed variations were modeled in this paper by simple equations that partially enabled characterization of the cocowood fibrovascular tissue system. Furthermore, 11 finite element analyses (FEA) were performed over a three dimensional (3D) finite element (FE) model resembling a characteristic coconut palm stem of 25 m in height to analyze the biomaterial reactions produced by the progressive deviation of the tangential fibrovascular bundles on the cocowood mechanical response (i.e., on the material compressive strength and the bending stiffness). The analyses in this study were carried out for the critical wind speed of 23 m/s (i.e., Gale tornado according to the Fujita tornado scale). For each analysis, the characteristic average maxima degree of orientation of the cocowood fibrovascular bundles was varied from 0° to 51°. The acquired results provided a deep understanding of the cocowood optimum

Representatives of countries participating in the International Space Station toured KSC's Space Sta

NASA Technical Reports Server (NTRS)

1998-01-01

Senior government officials from 15 countries participating in the International Space Station (ISS) signed agreements in Washington D.C. on Jan. 29 to establish the framework of cooperation among the partners on the design, development, operation and utilization of the Space Station. Acting Secretary of State Strobe Talbott signed the 1998 Intergovernmental Agreement on Space Station Cooperation with representatives of Russia, Japan, Canada, and participating countries of the European Space Agency (ESA), including Belgium, Denmark, France, Germany, Italy, the Netherlands, Norway, Spain, Sweden, Switzerland, and the United Kingdom. Some of these officials then toured KSC's Space Station Processing Facility (SSPF) with NASA Administrator Daniel Goldin, at front, sixth from the left. They are, left to right, front to back: Hidetoshi Murayama, National Space Development Agency of Japan (NASDA); Louis Laurent, Embassy of France; Haakon Blankenborg, Norwegian Parliament Standing Committee on Foreign Affairs; His Excellency Joris Vos, ambassador of the Netherlands; His Excellency Tom Vraalsen, ambassador of Norway; Daniel Goldin; Luigi Berlinguer, Italian minister for education, scientific, and technological research; Antonio Rodota, director general, European Space Agency (ESA); Yvan Ylieff, Belgian minister of science and chairman of the ESA Ministerial Council; Jacqueline Ylieff; Masaaki Komatsu, KSC local NASDA representative and interpreter; Serge Ivanets, space attache, Embassy of Russia; Hiroshi Fujita, Science and Technology Agency of Japan; Akira Mizutani, Japanese Ministry of Foreign Affairs; Peter Grognard, science attache, Royal Embassy of Belgium; Michelangelo Pipan, Italian diplomatic counselor to the minister; His Excellency Gerhard Fulda, German Federal Foreign Office; Jorg Feustel-Buechl, ESA director of manned space flight and microgravity; A. Yakovenko, Russian Ministry of Foreign Affairs; JoAnn Morgan, KSC associate director for Advanced Development

High-beta steady-state research with integrated modeling in the JT-60 Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozeki, T.

2007-05-15

Improvement of high-beta performance and its long sustainment was obtained with ferritic steel tiles in the JT-60 Upgrade (JT-60U) [T. Fujita et al., Phys. Plasmas 50, 104 (2005)], which were installed inside the vacuum vessel to reduce fast ion loss by decreasing the toroidal field ripple. When a separation between the plasma surface and the wall was small, high-beta plasmas reached the ideal wall stability limit, i.e., the ideal magnetohydrodynamics stability limit with the wall stabilization. A small rotation velocity of 0.3% of the Alfven velocity was found to be effective for suppressing the resistive wall mode. Sustainment of themore » high normalized beta value of {beta}{sub N}=2.3 has been extended to 28.6 s ({approx}15 times the current diffusion time) by improvement of the confinement and increase in the net heating power. Based on the research in JT-60U experiments and first-principle simulations, integrated models of core, edge-pedestal, and scrape-off-layer (SOL) divertors were developed, and they clarified complex features of reactor-relevant plasmas. The integrated core plasma model indicated that the small amount of electron cyclotron (EC) current density of about half the bootstrap current density could effectively stabilize the neoclassical tearing mode by the localized EC current accurately aligned to the magnetic island center. The integrated edge-pedestal model clarified that the collisionality dependence of energy loss due to the edge-localized mode was caused by the change in the width of the unstable mode and the SOL transport. The integrated SOL-divertor model clarified the effect of the exhaust slot on the pumping efficiency and the cause of enhanced radiation near the X-point multifaceted asymmetric radiation from edge. Success in these consistent analyses using the integrated code indicates that it is an effective means to investigate complex plasmas and to control the integrated performance.« less

PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients.

PubMed

Nakaoka, Kazunori; Hashimoto, Senju; Kawabe, Naoto; Nitta, Yoshifumi; Murao, Michihito; Nakano, Takuji; Shimazaki, Hiroaki; Kan, Toshiki; Takagawa, Yuka; Ohki, Masashi; Kurashita, Takamitsu; Takamura, Tomoki; Nishikawa, Toru; Ichino, Naohiro; Osakabe, Keisuke; Yoshioka, Kentaro

2015-01-01

To investigate associations between patatin-like phospholipase domain-containing 3 (PNPLA3) genotypes and fibrosis and hepatocarcinogenesis in Japanese chronic hepatitis C (CHC) patients. Two hundred and thirty-one patients with CHC were examined for PNPLA3 genotypes, liver stiffness measurements (LSM), and hepatocellular carcinoma (HCC) from May 2010 to October 2012 at Fujita Health University Hospital. The rs738409 single nucleotide polymorphism (SNP) encoding for a functional PNPLA3 I148M protein variant was genotyped using a TaqMan predesigned SNP genotyping assay. LSM was determined as the velocity of a shear wave (Vs) with an acoustic radiation force impulse. Vs cut-off values for cirrhosis were set at 1.55 m/s. We excluded CHC patients with a sustained virological response or relapse after interferon treatment. PNPLA3 genotypes were CC, CG, and GG for 118, 72, and 41 patients, respectively. Multivariable logistic regression analysis selected older age (OR = 1.06; 95% CI: 1.03-1.09; p < 0.0001), higher body mass index (BMI) (OR= 1.12; 95% CI: 1.03-1.22; p = 0.0082), and PNPLA3 genotype GG (OR = 2.07; 95% CI: 0.97-4.42; p = 0.0599) as the factors independently associated with cirrhosis. When 137 patients without past history of interferon treatment were separately assessed, multivariable logistic regression analysis selected older age (OR = 1.05; 95% CI: 1.02-1.09; p = 0.0034), and PNPLA3 genotype GG (OR = 3.35; 95% CI: 1.13-9.91; p = 0.0291) as the factors independently associated with cirrhosis. Multivariable logistic regression analysis selected older age (OR = 1.12; 95% CI: 1.07-1.17; p < 0.0001), PNPLA3 genotype GG (OR = 2.62; 95% CI: 1.15-5.96; p = 0.0218), and male gender (OR = 1.83; 95% CI: 0.90-3.71); p = 0.0936) as the factors independently associated with HCC. PNPLA3 genotype I148M is one of risk factors for developing HCC in Japanese CHC patients, and is one of risk factors for progress to cirrhosis in the patients without past history of

KSC-98pc246

NASA Image and Video Library

1998-01-30

CAPE CANAVERAL, Fla. -- In the International Space Station Processing Facility at NASA's Kennedy Space Center in Florida, senior government officials from 15 countries participating in the space station program signed agreements in Washington D.C. on Jan. 29 to establish the framework of cooperation among the partners on the design, development, operation and utilization of the space station. Acting Secretary of State Strobe Talbott signed the 1998 Intergovernmental Agreement on Space Station Cooperation with representatives of Russia, Japan, Canada, and participating countries of the European Space Agency ESA -- Belgium, Denmark, France, Germany, Italy, the Netherlands, Norway, Spain, Sweden, Switzerland, and the United Kingdom. Some of these officials then toured Kennedy's Space Station Processing Facility SSPF with NASA Administrator Daniel Goldin, at front, sixth from the left. They are, left to right, front to back: Hidetoshi Murayama, National Space Development Agency of Japan NASDA Louis Laurent, Embassy of France Haakon Blankenborg, Norwegian Parliament Standing Committee on Foreign Affairs His Excellency Joris Vos, ambassador of the Netherlands His Excellency Tom Vraalsen, ambassador of Norway Goldin Luigi Berlinguer, Italian minister for education, scientific, and technological research Antonio Rodota, director general, ESA Yvan Ylieff, Belgian minister of science and chairman of the ESA Ministerial Council Jacqueline Ylieff Masaaki Komatsu, Kennedy local NASDA representative and interpreter Serge Ivanets, space attache, Embassy of Russia Hiroshi Fujita, Science and Technology Agency of Japan Akira Mizutani, Japanese Ministry of Foreign Affairs Peter Grognard, science attache', Royal Embassy of Belgium Michelangelo Pipan, Italian diplomatic counselor to the minister His Excellency Gerhard Fulda, German Federal Foreign Office Jorg Feustel-Buechl, ESA director of manned space flight and microgravity A. Yakovenko, Russian Ministry of Foreign Affairs Jo

Heterologous co-expression in E. coli of isoamylase genes from cassava Manihot esculenta Crantz 'KU50' achieves enzyme-active heteromeric complex formation.

PubMed

Panpetch, Pawinee; Field, Robert A; Limpaseni, Tipaporn

2018-03-01

Cloning of two isoamylase genes, MeISA1 and MeISA2, from cassava (Manihot esculenta Crantz) tubers, accompanied by their co-expression in E. coli demonstrates a requirement for heteromeric complex formation to achieve debranching activity. Starch debranching enzyme (DBE) or isoamylase (ISA) (EC.3.2.1.68), an important enzyme in starch metabolism, catalyses the hydrolysis of α-1,6 glycosidic linkages of amylopectin. Isoforms of ISAs have been reported in higher plants and algae (Fujita et al. in Planta 208:283-293, 1999; Hussain et al. in Plant Cell 15:133-149, 2003; Ishizaki et al. in Agric Biol Chem 47:771-779, 1983; Mouille et al. in Plant Cell 8:1353-1366, 1996). In the current work, cassava ISA genes were isolated from cDNA generated from total RNA from tubers of Manihot esculanta Crantz cultivar KU50. MeISA1 and MeISA2 were successfully amplified and cloned into a pETDuet1 vector. The putative MeISA1 and MeISA2 proteins comprised 763 and 882 amino acids, with substantial similarity to StISA1 and StISA2 from potato (84.4% and 68.9%, respectively). Recombinant MeISA1 and MeISA2 were co-expressed in Escherichia coli SoluBL21 (DE3). Histrap TM -Purified rMeISA1 and rMeISA2 showed approximate molecular weights of 87 and 99 kDa, respectively, by SDS-PAGE. Debranching activity was only detectable in the column fractions where both recombinant ISA isoforms were present. The heteromeric DBE from crude extracts of 4-5 h induced cultures analysed by gel filtration chromatography and western blot showed combinations of rMeISA1 and rMeISA2 at ratios of 1:1 to 4:1. Pooled fractions with DBE activity were used for enzyme characterisation, which showed that the enzyme was specific for amylopectin, with optimum activity at 37 °C and pH 7.0. Enzyme activity was enhanced by Co 2+ , Mg 2+ and Ca 2+ , but was strongly inhibited by Cu 2+ . Debranched amylopectin products showed chain length distributions typical of plant DBE.

Sharpest views of Betelgeuse reveal how supergiant stars lose mass-Unveiling the true face of a behemoth

NASA Astrophysics Data System (ADS)

2009-07-01

the size of a tennis ball on the International Space Station (ISS), as seen from the ground. "Thanks to these outstanding images, we have detected a large plume of gas extending into space from the surface of Betelgeuse," says Pierre Kervella from the Paris Observatory, who led the team. The plume extends to at least six times the diameter of the star, corresponding to the distance between the Sun and Neptune. "This is a clear indication that the whole outer shell of the star is not shedding matter evenly in all directions," adds Kervella. Two mechanisms could explain this asymmetry. One assumes that the mass loss occurs above the polar caps of the giant star, possibly because of its rotation. The other possibility is that such a plume is generated above large-scale gas motions inside the star, known as convection - similar to the circulation of water heated in a pot. To arrive at a solution, astronomers needed to probe the behemoth in still finer detail. To do this Keiichi Ohnaka from the Max Planck Institute for Radio Astronomy in Bonn, Germany, and his colleagues used interferometry. With the AMBER instrument on ESO's Very Large Telescope Interferometer, which combines the light from three 1.8-metre Auxiliary Telescopes of the VLT, the astronomers obtained observations as sharp as those of a giant, virtual 48-metre telescope. With such superb resolution, the astronomers were able to detect indirectly details four times finer still than the amazing NACO images had already allowed (in other words, the size of a marble on the ISS, as seen from the ground). "Our AMBER observations are the sharpest observations of any kind ever made of Betelgeuse. Moreover, we detected how the gas is moving in different areas of Betelgeuse's surface ― the first time this has been done for a star other than the Sun", says Ohnaka. The AMBER observations revealed that the gas in Betelgeuse's atmosphere is moving vigorously up and down, and that these bubbles are as large as the

Spatial-temporal clustering of tornadoes

NASA Astrophysics Data System (ADS)

Malamud, Bruce D.; Turcotte, Donald L.; Brooks, Harold E.

2016-12-01

The standard measure of the intensity of a tornado is the Enhanced Fujita scale, which is based qualitatively on the damage caused by a tornado. An alternative measure of tornado intensity is the tornado path length, L. Here we examine the spatial-temporal clustering of severe tornadoes, which we define as having path lengths L ≥ 10 km. Of particular concern are tornado outbreaks, when a large number of severe tornadoes occur in a day in a restricted region. We apply a spatial-temporal clustering analysis developed for earthquakes. We take all pairs of severe tornadoes in observed and modelled outbreaks, and for each pair plot the spatial lag (distance between touchdown points) against the temporal lag (time between touchdown points). We apply our spatial-temporal lag methodology to the intense tornado outbreaks in the central United States on 26 and 27 April 2011, which resulted in over 300 fatalities and produced 109 severe (L ≥ 10 km) tornadoes. The patterns of spatial-temporal lag correlations that we obtain for the 2 days are strikingly different. On 26 April 2011, there were 45 severe tornadoes and our clustering analysis is dominated by a complex sequence of linear features. We associate the linear patterns with the tornadoes generated in either a single cell thunderstorm or a closely spaced cluster of single cell thunderstorms moving at a near-constant velocity. Our study of a derecho tornado outbreak of six severe tornadoes on 4 April 2011 along with modelled outbreak scenarios confirms this association. On 27 April 2011, there were 64 severe tornadoes and our clustering analysis is predominantly random with virtually no embedded linear patterns. We associate this pattern with a large number of interacting supercell thunderstorms generating tornadoes randomly in space and time. In order to better understand these associations, we also applied our approach to the Great Plains tornado outbreak of 3 May 1999. Careful studies by others have associated

Spatial-Temporal Clustering of Tornadoes

NASA Astrophysics Data System (ADS)

Malamud, Bruce D.; Turcotte, Donald L.; Brooks, Harold E.

2017-04-01

The standard measure of the intensity of a tornado is the Enhanced Fujita scale, which is based qualitatively on the damage caused by a tornado. An alternative measure of tornado intensity is the tornado path length, L. Here we examine the spatial-temporal clustering of severe tornadoes, which we define as having path lengths L ≥ 10 km. Of particular concern are tornado outbreaks, when a large number of severe tornadoes occur in a day in a restricted region. We apply a spatial-temporal clustering analysis developed for earthquakes. We take all pairs of severe tornadoes in observed and modelled outbreaks, and for each pair plot the spatial lag (distance between touchdown points) against the temporal lag (time between touchdown points). We apply our spatial-temporal lag methodology to the intense tornado outbreaks in the central United States on 26 and 27 April 2011, which resulted in over 300 fatalities and produced 109 severe (L ≥ 10 km) tornadoes. The patterns of spatial-temporal lag correlations that we obtain for the 2 days are strikingly different. On 26 April 2011, there were 45 severe tornadoes and our clustering analysis is dominated by a complex sequence of linear features. We associate the linear patterns with the tornadoes generated in either a single cell thunderstorm or a closely spaced cluster of single cell thunderstorms moving at a near-constant velocity. Our study of a derecho tornado outbreak of six severe tornadoes on 4 April 2011 along with modelled outbreak scenarios confirms this association. On 27 April 2011, there were 64 severe tornadoes and our clustering analysis is predominantly random with virtually no embedded linear patterns. We associate this pattern with a large number of interacting supercell thunderstorms generating tornadoes randomly in space and time. In order to better understand these associations, we also applied our approach to the Great Plains tornado outbreak of 3 May 1999. Careful studies by others have associated

Cloud-to-Ground Lightning Characteristics of a Major Tropical Cyclone Tornado Outbreak

NASA Technical Reports Server (NTRS)

McCaul, Eugene W., Jr.; Buechler, Dennis; Goodman, Steven J.

1999-01-01

It is well known that most tropical cyclones (TCs) that make landfall along the Gulf coast of the United States spawn at least a few tornadoes. Although most landfalling TCs generate fewer than a dozen such tornadoes, a small proportion produce large swarm outbreaks, with as many as 25 or more tornadoes. Usually, these major outbreaks occur in large, intense hurricane-strength TCs, but on 15-17 August 1994 Tropical Storm Beryl spun off 37 tornadoes along its path from the Florida panhandle through the mid-Atlantic states. Some 32 of these tornadoes occurred on 16 August 1994 from eastern Georgia to southern Virginia, with most of these taking place in South Carolina. Beryl's 37 tornadoes moved it into what was at that time fifth place historically in terms of TC tornado productivity. The Beryl outbreak is especially noteworthy in that at least three of the tornadoes achieved peak intensity of F3 on the Fujita damage intensity scale. Although no fatalities resulted from the Beryl outbreak, at least 50 persons suffered injuries, and property damages totalled more than $50 million . The Beryl outbreak is a good example of a TC whose greatest danger to the public is its post-landfall severe weather. In this respect, and in the character of its swarm outbreak of tornadoes, it resembles another large tornado outbreak spawned by a relatively weak TC, Hurricane Danny of 1985). In the Danny outbreak, numerous shallow mini-supercell storms were found to have occurred, and it was noted that, because of the storms' relatively shallow depth, cloud-to-ground (CG) lightning was negligible. Better observations of future TC tornado outbreaks, especially with modern surveillance tools such as Doppler radars and the National Lightning Detection Network (NLDN), were recommended. Although the Beryl tornado outbreak is not the first set of TC-spawned tornado storms to be observed with the NLDN, it is one of the largest and likely the most intense such outbreak. The purpose of this paper

PREFACE: Fullerene Nano Materials (Symposium of IUMRS-ICA2008)

NASA Astrophysics Data System (ADS)

Miyazawa, Kun'ichi; Fujita, Daisuke; Wakahara, Takatsugu; Kizuka, Tokushi; Matsuishi, Kiyoto; Ochiai, Yuichi; Tachibana, Masaru; Ogata, Hironori; Mashino, Tadahiko; Kumashiro, Ryotaro; Oikawa, Hidetoshi

2009-07-01

. This symposium was partly supported by the Coordination Program of Science and Technology Projects ''Developing Nanotechnologies and Engaging the Public'' conducted by the Council for Science and Technology Policy (CSTP) and funded by Special Coordination Funds for Promoting Science and Technology. Organizing committee of Symposium N (IUMRS-ICA 2008) Chair Kun'ichi Miyazawa (National Institute for Materials Science, Japan) Vice Chairs Daisuke Fujita (National Institute for Materials Science, Japan) Takatsugu Wakahara (National Institute for Materials Science, Japan) Tokushi Kizuka (Tsukuba University, Japan) Kiyoto Matsuishi (Tsukuba University, Japan) Yuichi Ochiai (Chiba University, Japan) Masaru Tachibana (Yokohama City University, Japan) Hironori Ogata (Hosei University, Japan) Tadahiko Mashino (Keio University, Japan) Ryotaro Kumashiro (Tohoku University, Japan) Hidetoshi Oikawa (Tohoku University, Japan)

A proposal of monitoring and forecasting system for crustal activity in and around Japan using a large-scale high-fidelity finite element simulation codes

NASA Astrophysics Data System (ADS)

Hori, Takane; Ichimura, Tsuyoshi; Takahashi, Narumi

2017-04-01

Here we propose a system for monitoring and forecasting of crustal activity, such as spatio-temporal variation in slip velocity on the plate interface including earthquakes, seismic wave propagation, and crustal deformation. Although, we can obtain continuous dense surface deformation data on land and partly on the sea floor, the obtained data are not fully utilized for monitoring and forecasting. It is necessary to develop a physics-based data analysis system including (1) a structural model with the 3D geometry of the plate interface and the material property such as elasticity and viscosity, (2) calculation code for crustal deformation and seismic wave propagation using (1), (3) inverse analysis or data assimilation code both for structure and fault slip using (1) & (2). To accomplish this, it is at least necessary to develop highly reliable large-scale simulation code to calculate crustal deformation and seismic wave propagation for 3D heterogeneous structure. Actually, Ichimura et al. (2015, SC15) has developed unstructured FE non-linear seismic wave simulation code, which achieved physics-based urban earthquake simulation enhanced by 1.08 T DOF x 6.6 K time-step. Ichimura et al. (2013, GJI) has developed high fidelity FEM simulation code with mesh generator to calculate crustal deformation in and around Japan with complicated surface topography and subducting plate geometry for 1km mesh. Fujita et al. (2016, SC16) has improved the code for crustal deformation and achieved 2.05 T-DOF with 45m resolution on the plate interface. This high-resolution analysis enables computation of change of stress acting on the plate interface. Further, for inverse analyses, Errol et al. (2012, BSSA) has developed waveform inversion code for modeling 3D crustal structure, and Agata et al. (2015, AGU Fall Meeting) has improved the high-fidelity FEM code to apply an adjoint method for estimating fault slip and asthenosphere viscosity. Hence, we have large-scale simulation and

Annually-resolved temperature reconstructions of the past 2000 years from Dome-Fuji, East Antarctica

NASA Astrophysics Data System (ADS)

Motizuki, Yuko; Takahashi, Kazuya; Nakai, Yoichi; Motoyama, Hideaki

2016-04-01

We present annually-resolved temperature and SST reconstructions of the past 2000 years based on water (oxygen and deuterium) isotope measurement on a shallow ice core drilled in 2010 at Dome Fuji station, East Antarctica. These time series records will be an essential contribution to the PAGES 2k project from sparse data area in Antarctica. Dome Fuji station is located on a summit of Dronning Maud Land at an altitude of 3810 m a.s.l. (above sea level) (77o19'01'' S, 39o42'12'' E) in East Antarctica. The 10 m depth mean snow temperature at Dome Fuji is -57.3oC1). The inland area around Dome Fuji has been recognized to be especially unique: The snow and ice there contain much stratospheric information. The direct evidence for this comes from tritium contents originated from the nuclear bomb tests in the 1960s; the tritium fallout at the Dome Fuji site is outstandingly high among 16 snow pit samples widely collected over Antarctica2). To date the concerned Dome Fuji ice core, we applied volcanic signature matching to transfer the West Antarctic Ice Sheet (WAIS) Divide ice core chronology constructed by annual layer counting as used in the study by Sigl et al. (2014)3). In our presentation, we confine ourselves to discuss the oscillation periodicity that we observed in the oxygen isotope record in our data: The periods of approximately 10, 20, and 200 years were found. We will present the time series analyses for this in detail, and will discuss the origin of this periodicity. References: 1) Kameda, T., Motoyama, H., Fujita, S., and Takahashi, S.: "Past temporal and spatial variability of surface mass balance at Dome Fuji", East Antarctica, by the stake method from 1995 to 2006, J. Glaciol., 54, 107-116, 2008. 2) Fourre, E., Jean-Baptiste, P., Dapoigny, A., Baumier, D., Petit, J.-R., and Jouzel, J.: "Past and recent tritium levels in Arctic and Antarctic polar caps", Earth Planet. Sc. Lett., 245, 56-64, 2006. 3) Sigl, M., J. McConnell, M. Toohey, M. Curran, S. Das, R

EDITORIAL: Invited review and topical lectures from the 13th International Congress on Plasma Physics

NASA Astrophysics Data System (ADS)

Zagorodny, A.; Kocherga, O.

2007-05-01

The 13th International Congress on Plasma Physics (ICPP 2006) was organized, on behalf of the International Advisory Committee of the ICPP series, by the National Academy of Sciences of Ukraine and the Bogolyubov Institute for Theoretical Physics (BITP) and held in Kiev, Ukraine, 22 26 May 2006. The Congress Program included the topics: fundamental problems of plasma physics; fusion plasmas; plasmas in astrophysics and space physics; plasmas in applications and technologies; complex plasmas. A total of 305 delegates from 30 countries took part in the Congress. The program included 9 invited review lectures, 32 invited topical and 313 contributed papers (60 of which were selected for oral presentation). The Congress Program was the responsibility of the International Program Committee: Anatoly Zagorodny (Chairman) Bogolyubov Institute for Theoretical Physics, Ukraine Olha Kocherga (Scientific Secretary) Bogolyubov Institute for Theoretical Physics, Ukraine Boris Breizman The University of Texas at Austin, USA Iver Cairns School of Physics, University of Sydney, Australia Tatiana Davydova Institute for Nuclear Research, Ukraine Tony Donne FOM-Institute for Plasma Physics, Rijnhuizen, The Netherlands Nikolai S Erokhin Space Research Institute of RAS, Russia Xavier Garbet CEA, France Valery Godyak OSRAM SYLVANIA, USA Katsumi Ida National Institute for Fusion Science, Japan Alexander Kingsep Russian Research Centre `Kurchatov Institute', Russia E P Kruglyakov Budker Institute of Nuclear Physics, Russia Gregor Morfill Max-Planck-Institut für extraterrestrische Physik, Germany Osamu Motojima National Institute for Fusion Science, Japan Jef Ongena ERM-KMS, Brussels and EFDA-JET, UK Konstantyn Shamrai Institute for Nuclear Research, Ukraine Raghvendra Singh Institute for Plasma Research, India Konstantyn Stepanov Kharkiv Institute of Physics and Technology, Ukraine Masayoshi Tanaka National Institute for Fusion Science, Japan Nodar Tsintsadze Physics Institute, Georgia The

The life-cycle of the digenetic trematode, Proctoeces maculatus (Looss, 1901) Odhner, 1911 (Syn. P. rubtenuis [Linton, 1907] Hanson, 1950), and description of Cerceria adranocerca n. sp

USGS Publications Warehouse

Stunkard, H.W.; Uzmann, J.R.

1959-01-01

The genus Proctoeces was erected by Odhner ( 191 1) to contain Distonium maculatuni Looss, 1901, from Labrus merula and Crenilabrus spp. at Triest. Odhner had found the parasite in Blennius ocellaris at Naples. One adult specimen from Chrysophrys bifasciata and two immature specimens from lulis lunaris taken in the Red Sea, were described as a new species, Proctoeces erythraeus. Dawes (1946) listed P. erythraeus as a synonym of  P. maculatus (Looss) , but the species was recognized by Manter ( 1947) on the basis of six specimens he had collected from Calamus calamus and Calamus bajonado at the biological laboratory of the Carnegie Institution at Dry Tortugas, Florida. Several additional species have been de scribed. Fujita ( 1925) reported a metacercaria from the Japanese oyster, Ostrea gigas, as a new species, Proctoeces ostreae. The paper was translated by R. Ph. Dollfus who noted (p. 57) ,“Il est à souhaiter que des recherches chez les poissons mangers de Lamellibranches, sur les côtes de la préfecture d'Hiroshima, permettent de découvrir des exemplaires complètement adultes de Proctoeces ostreae Fuj., chez lesquels l'extension des vitellogènes et les dimensions des oeufs puissent être observées avec précision; il sera alors possible de savoir définitivement si P. ostreae Fuj. doit ou non tomber en synonymie avec P. maculatus (Looss)." Yamaguti (1934) described P. maculatus from Sparus aries, Sparws macrocephalus, Pagrosomus auratus, and Epinephelus akaara in Japan. Several specimens from Pagrosomus auratus, which differed from P. maculatus in larger size, larger eggs, and trilobed ovary, he described as a new species, Proctoeces major. Yamaguti ( 1938) reported P. nzaculatus from Sensicossyphus reticulatus and described a larva from the liver of the pelecypod mollusk, Brachidontes senhausi, as an unidentified member of the genus Proctoeces. Manter ( 1940) described Proctoeces tnagnorus from a single specimen found in the intestine of Caulolatilus

The Relationship between Tornado Reports and Cloud-to-Ground Lightning Polarity in the Southeastern United States during the Cool Season from 1989 to 2002

NASA Astrophysics Data System (ADS)

Carey, L. D.; Butts, D. A.

2006-12-01

Several past case and climatological studies have analyzed the relationship between tornadogenesis and cloud-to-ground (CG) lightning polarity. In particular, there has been an emphasis on investigating when and under what environmental and storm conditions tornadoes are associated with anomalous positive CG lightning in order to understand cloud electrification mechanisms and to explore tornado nowcasting opportunities using National Lightning Detection Network (NLDN) CG lightning data. Most of the case and all of the climatological studies have been conducted during the warm season (April to September). In the southeastern United States, a significant number of tornadoes occur in the cool season (October to March). To address this gap in our climatological knowledge, we extend past research by determining the NLDN ground flash properties, including polarity, flash density, peak current, and multiplicity, in the vicinity of tornado reports during the cool season from 1989 2002 in the southeastern United States (i.e., from 102 to 72 degrees west longitude and from 24 to 42 degrees north latitude). Following past studies, we examined NLDN CG lightning properties within 50 km and one hour prior to all tornado reports (i.e., F0 - F5 on the Fujita damage scale). Interestingly, no NLDN detected ground flash activity occurred in the vicinity of 967 (29 %) of the 3325 tornado reports in our sample. Only 10 % (236) of the remaining 2358 tornado reports were associated with predominately (> 50 %) positive CG (PPCG) lightning activity. About 25 % (598) of the tornado reports accompanied by ground flash activity were associated with > 25 % positive CG polarity. In our analysis domain, the geographic frequency maximum of tornadoes accompanied by PPCG lightning activity occurred in a north-south oriented region centered on central Kansas that extended northward into Nebraska and southward into Oklahoma. In this preferred region, 30 % to 60 % of all cool season tornado reports

SABRE observations of Pi2 pulsations: case studies

NASA Astrophysics Data System (ADS)

Bradshaw, E. G.; Lester, M.

1997-01-01

(Imperial College, London), J. C. Samson (University of Alberta, Edmonton), L. J. Lanzerotti (AT&T Bell Laboratories), A. Wolfe (New York City Technical College) and to Dr. M. Vellante (University of LÁquila) for helpful discussions. They also thank Dr. A. Meloni (Istituto Nazionale di Geofisica, Roma) who made available geomagnetic field observations from LÁquila Geomagnetic Observatory. This research activity at LÁquila is supported by MURST (40% and 60% contracts) and by GIFCO/CNR. Topical Editor K.-H. Glaßmeier thanks C. Waters and S. Fujita for their help in evaluating this paper.-> Correspondence to :P. Francia->

Methodology for a GIS-based damage assessment for researchers following large scale disasters

NASA Astrophysics Data System (ADS)

Crawford, Patrick Shane

research field. Along with visually mapping the data, geometric calculations can be conducted on the data to give the viewer more information about the damage. In Chapter 4, a tornado damage contour for Moore, Oklahoma following the May 20, 2013 tornado is shown. This damage contour was created in GIS based on the Enhanced Fujita (EF) damage scale, and gives the viewer an easily understood picture of the extent and distribution of the tornado. This thesis aims to describe a foundational groundwork for activities that are performed in the GIS-based damage assessment procedure and provide uses for the damage assessment as well as research being conducted on how to use the data collected from these assessments. This will allow researchers to conduct a highly adaptable, rapid GIS-based damage assessment of their own.

PREFACE: 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) and 25th Symposium on Plasma Science for Materials (SPSM-25)

NASA Astrophysics Data System (ADS)

Watanabe, Takayuki; Kaneko, Toshio; Sekine, Makoto; Tanaka, Yasunori

2013-06-01

advances in thermal and non-equilibrium plasmas as well as on more new and innovative developments in the field of life innovation, green innovation and a technical report session. The editors hope that this volume will be useful and helpful for deepening our understanding of science and technology of plasma materials processing and also for stimulating further development of the plasma technology. Finally, we would like to thank the conference chairmen, the members of the organizing committee, the advisory committee, the executive committee, the program committee, the publication committee, organizing secretariat and financial support from The 153rd Committee on Plasma Materials Science, JSPS. Sponsors and Supporting Organization: The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science Organizing Committee Chairperson: Osamu Tsuji, SAMCO Corporation, Japan Advisory Committee Chairperson: Akihisa Matsuda, Osaka University, Japan Executive Committee Chairperson: Masaru Hori, Nagoya University, Japan Program Committee Chairperson: Takamasa Ishigaki, Hosei University, Japan Publication Committee Chairperson: Takayuki Watanabe, Kyushu University Editors of APCPST-11 and SPMS-25 Professor Takayuki Watanabe, Kyushu University, Japan Professor Toshio Kaneko, Tohoku University, Japan Professor Makoto Sekine, Nagoya University, Japan Professor Yasunori Tanaka, Kanazawa University, Japan

Incorporating TPC observed parameters and QuikSCAT surface wind observations into hurricane initialization using 4D-VAR approaches

NASA Astrophysics Data System (ADS)

Park, Kyungjeen

This study aims to develop an objective hurricane initialization scheme which incorporates not only forecast model constraints but also observed features such as the initial intensity and size. It is based on the four-dimensional variational (4D-Var) bogus data assimilation (BDA) scheme originally proposed by Zou and Xiao (1999). The 4D-Var BDA consists of two steps: (i) specifying a bogus sea level pressure (SLP) field based on parameters observed by the Tropical Prediction Center (TPC) and (ii) assimilating the bogus SLP field under a forecast model constraint to adjust all model variables. This research focuses on improving the specification of the bogus SLP indicated in the first step. Numerical experiments are carried out for Hurricane Bonnie (1998) and Hurricane Gordon (2000) to test the sensitivity of hurricane track and intensity forecasts to specification of initial vortex. Major results are listed below: (1) A linear regression model is developed for determining the size of initial vortex based on the TPC observed radius of 34kt. (2) A method is proposed to derive a radial profile of SLP from QuikSCAT surface winds. This profile is shown to be more realistic than ideal profiles derived from Fujita's and Holland's formulae. (3) It is found that it takes about 1 h for hurricane prediction model to develop a conceptually correct hurricane structure, featuring a dominant role of hydrostatic balance at the initial time and a dynamic adjustment in less than 30 minutes. (4) Numerical experiments suggest that track prediction is less sensitive to the specification of initial vortex structure than intensity forecast. (5) Hurricane initialization using QuikSCAT-derived initial vortex produced a reasonably good forecast for hurricane landfall, with a position error of 25 km and a 4-h delay at landfalling. (6) Numerical experiments using the linear regression model for the size specification considerably outperforms all the other formulations tested in terms of the

EDITORIAL: Editorial from the new Editor-in-Chief for 2014 Editorial from the new Editor-in-Chief for 2014

NASA Astrophysics Data System (ADS)

Graham, W. G.

2014-02-01

from receipt-to-first decision of a paper is only 50 days. In 2014 we will continue to support the low-temperature plasma physics community through the publication of special topical issues. Those already scheduled for next year are: Transport in B-fields in low temperature plasmas, Guest Editors: Rod Boswell and Igor D Kaganovich Spots and patterns on electrodes of gas discharges, Guest Editors: Mikhail S Benilov and Ulrich Kogelschatz Interaction of electromagnetic waves with low temperature plasmas, Guest Editors: Osamu Sakai and Shahid Rauf We will also launch a new feature: LabTalks, a way in which our authors can showcase their group's work and communicate their research published in PSST to a wider audience. Full details are on the PSST website. Along with the leadership team, made up of Associate Editors, Anne, Nick and Richard and the great PSST staff at Institute of Physics Publishing, led by Alice Malhador, I will strive to grow, improve and deliver a journal which reflects the excellent science from the low-temperature plasma community. We hope we can continue to count on your vital support as authors and referees.

PREFACE: 15th International Conference on Thin Films (ICTF-15)

NASA Astrophysics Data System (ADS)

Takai, Osamu; Saito, Nagahiro; Zettsu, Nobuyuki; Cho, Sung-Pyo; Terashima, Chiaki; Ueno, Tomonaga; Sakai, Osamu; Miyazaki, Seiichi; Yoshimura, Kazuki; Akamatsu, Kensuke; Ito, Takahiro; Yogo, Toshinobu; Inoue, Yasushi; Ohtake, Naoto; Yoshida, Tsukasa; Tosa, Masahiro; Takai, Madoka; Fujiwara, Yasufumi; Matsuda, Naoki; Teshima, Katsuya; Seki, Takahiro; Matsunaga, Katsuyuki; Fujita, Daisuke

2013-03-01

in the ancient temples and shrines, as well as private houses, which are built in styles unique to Kyoto. Furthermore, many festivals, ceremonies and traditional activities reveal the will of this city to convey and develop its 1200-year-old culture. Participants of the conference will also be able to see many world heritage sites in the city. Moreover, November is the best time of year to visit Kyoto. We hope you will enjoy Kyoto very much. We would like to offer our thanks for all the contributions from the members of the International Advisory Committee and Organizing Committee, Symposium Chairs, the Secretary General, the Thin Film Division of IUVSTA (chair: Professor Dr Alberto Tagliaferro), IUVSTA, VSJ and other cooperating societies, and to all of the supporting organizations and enterprises. We would also like to express our thanks to all of the participants, secretariat members and members of the supporting staff. I am very pleased to welcome you to ICTF-15 and Kyoto! Director Professor Dr Osamu Takai Chairperson of ICTF-15 EcoTopia Science Institute, and Department of Materials, Physics and Energy Engineering Graduate School of Engineering Nagoya University Japan

New Light on Dark Energy

NASA Astrophysics Data System (ADS)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The

The Growing-up of a Star

NASA Astrophysics Data System (ADS)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The

[Current status of tuberculosis education in universities and future tasks].

PubMed

2000-02-01

Symposium Topics and Presenters: 1. Education of tuberculosis in medial school: Kaoru SHIMOKATA (Department of Clinical Preventive Medicine, Nagoya University Daiko Medical Center) 2. From Medical University holding Tuberculous ward: Shosaku ABE (Third Department of Internal Medicine, Sapporo Medical University School of Medicine), et al. 3. Necessity and Significance of Sanatorium ward associated with University Hospital: Saburo SONE, et al. (Third Department of Internal Medicine, The University of Tokushima School of Medicine) 4. A proposal on education and training for tuberculosis in medical school from aspect of sanitariums: Takeshi OGURA (Toneyama National Hospital) 5. How to avoid infecting TB and to prevent contracting TB while medical and nursing practices: Keiichi NAGAO (Health Sciences, Center, Chiba University), et al. 6. Special speech: A review of the year since TB patient rooms were included in a common ward as a part of ministry of welfare's model project: Shuji KURANE (Fourth Department of Internal Medicine, Nippon Medical School) Tuberculosis began to rank first in mortality rate in Japan in the Meiji Era, and especially since it did not conform to the "national wealth and military strength" that was the national policy of the time due to the high mortality rates in the early decades of life, it was referred to as the "disease that was destroying the country" and the "pandemic disease." Even after entering the Showa Era, tuberculosis long occupied first place as the cause of death in Japan, and it raged unchecked for a period after World War II. However, the prognosis of tuberculosis as a whole improved considerably as a result of the development of antituberculosis agents, such as streptomycin, and the advent of rifampicin made it a curable disease. Its rank as a cause of death subsequently fell precipitously, and many of the TB wards that had been established in university hospitals were closed as the numbers of patients rapidly declined. At the

Science Underlying 2008 Nobel Prizes

NASA Astrophysics Data System (ADS)

Caldwell, Bernadette A.

2009-01-01

JCE offers a wealth of materials for teaching and learning chemistry that you can explore online. In the list below, Bernadette Caldwell of the Editorial Staff suggests additional resources that are available through JCE for teaching the science behind some of the 2008 Nobel Prizes . Discovering and Applying the Chemistry of GFP The Royal Swedish Academy of Sciences awarded the 2008 Nobel Prize in Chemistry for the discovery and development of the green fluorescent protein, GFP to three scientists: Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien. These scientists led the field in discovering and introducing a fluorescing protein from jellyfish into cells and genes under study, which allows researchers to witness biochemistry in action. Now tags are available that emit light in different colors, revealing myriad biological processes and their interactions simultaneously. Identifying HPV and HIV, HIV's Replication Cycle, and HIV Virus-Host Interactions The Nobel Assembly at Karolinska Institutet awarded the 2008 Nobel Prize in Medicine or Physiology for their discovery of human immunodeficiency virus (HIV) to two scientists: Françoise Barré-Sinoussi and Luc Montagnier; and for his discovery of human papilloma viruses [HPV] causing cervical cancer to one scientist, Harald zur Hausen. Diseases caused by these infectious agents significantly affect global health. While isolating and studying the virus, researchers discovered HIV is an uncommon retrovirus that infects humans and relies on the host to make its viral DNA, infecting and killing the host's white blood cells, ultimately destroying the immune systems of infected humans. Related Resources at JCE Online The Journal has published articles relating to GFP specifically, and more generally to fluorescing compounds applied to biochemistry. The Journal has also published an article and a video on protease inhibition—a strategy to suppress HIV's biological processes. With the video clips, an accompanying guide

PREFACE: 14th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2014)

NASA Astrophysics Data System (ADS)

2014-11-01

create strong networks between researchers. We also provide nice opportunities to experience Japanese nature and culture. The special cruise to see the magnificent whirlpool up close will definitely be one of the highlights. Additionally, we will serve Awaji's traditional performing art, Awaji Ningyo Joruri, which has a history of over 500 years and has been inherited through the generations. There are many individuals we would like to thank for their support in organizing PowerMEMS2014. The TPC, chaired by Takayuki Fujita, have given us their valuable time and best effort in reviewing abstracts. The PowerMEMS School chair Yuji Suzuki and the expert speakers made the School possible. The local organizing committee, led by Kensuke Kanda has provided us with invaluable assistance in preparing the PowerMEMS2014 venue. The financial support from both the Tsutomu Nakauchi Foundation, the Hyogo International Association and the conference sponsors have also been gratefully appreciated. Finally, we would like to thank each of you for attending the conference and bringing your expertise. We wish you all a successful conference and an exciting and relaxing stay in Awaji Island.

Thermal Resistances in the Everest Area derived from Satellite Imagery using a Nonlinear Energy Balance Model

NASA Astrophysics Data System (ADS)

Rounce, D.; McKinney, D. C.

2013-12-01

., Diolaiuti, G., Cutler, M., Smiraglia, C. Meteorology and surface energy fluxes in the 2005-2007 ablation seasons at the Miage debris-covered glacier. J. Geoph. Res., 115, 2010 Foster, L., Brock, B., Cutler, M., Diotri, F. A physically based method for estimating supraglacial debris thickness from thermal band remote-sensing data. J. Glaciol. 58(210):677-691, 2012 Nakawo, M., Rana, B. Estimate of Ablation Rate of Glacier Ice Under a Supraglacial Debris Layer. Geografiska Annaler 81(4):695-701, 1999 Nicholson, L. Modelling melt beneath supraglacial debris: implications for the climatic response of debris-covered glaciers. PhD thesis, Univ. of St Andrews, 2004 Nicholson, L., Benn, D. Calculating ice melt beneath a debris layer using meteorological data. J. Glaciol. 52(178):463-470, 2006 Nicholson, L., Benn, D. Properties of Natural Supraglacial Debris in Relation to Modelling Sub-Debris Ice Ablation. Earth Surf. Proc. and Landforms 38(5):490-501, 2012 Reid, T., Brock, B. An Energy-Balance Model for Debris-Covered Glaciers Including Heat Conduction through the Debris Layer. J. Glaciol. 56(199):903-916, 2010 Zhang, Y., Fujita, K., Liu, S., Liu, Q., Nuimura, T. Distribution of Debris Thickness and its Effect on Ice Melt at Hailuogou Glacier. J. Glaciol. 57(206):1147-1157, 2011

List of Participants

NASA Astrophysics Data System (ADS)

2011-08-01

GonzalezBUAP, FCFM Lorenzo Díaz CruzBUAP Facultad de Ciencias Físico Matemáticas Luis Rey Díaz BarrónDivisión de Ciencias e Ingenierías Luis UrenaUniversidad de Guanajuato Magda LolaDept. of Physics, University of Patras, Greece Mahmoud WahbaEgyptian Center for Theoretical Physics, MTI Marcus S CohenNew Mexico State University Mario A Acero OrtegaICN - UNAM Mario E GomezUniversidad de Huelva Mark PipeUniversity of Sheffield Mauro NapsucialeDCI-UG Mirco CannoniUniversidad de Huelva Mónica Felipa Ramírez PalaciosUniversidad de Guadalajara Murli Manohar VermaLucknow university, India Nassim BozorgniaUCLA Octavio Obregón Octavio ValenzuelaIA-UNAM Oleg KamaevUniversity of Minnesota Osamu SetoHokkai-Gakuen University Pedro F González DíazIFF, CSIC, Serrano 121, 28006 Madrid, Spain Qaisar ShafiBartol Research Inst. and Delaware U. Raul Hennings-YeomansLos Alamos National Laboratory René Ángeles MartínezDepartamento de Fisica, del DCI de la Universidad de Guanajuato Reyna XoxocotziBUAP, FCFM Rishi Kumar TiwariGovt. Model Science College, Rewa (MP) INDIA Roberto A SussmanICN-UNAM Selim Gómez ÁvilaDCI-UG Sugai KenichiSaitama University Susana Valdez AlvaradoDCI-UG TVladimir - 2K CollaborationColorado State University Tonatiuh MatosCINVESTAV Valeriy DvoeglazovUniversidad de Zacatecas Vannia Gonzalez MaciasDCI-UG Vladimir Avila-ReeseInstituto de Astronomia, UNAM Wolfgang BietenholzINC, UNAM (Mexico) Yamanaka MasatoKyoto Sangyo University Yann MambriniLPT Orsay Yu-Feng ZhouInstitute of Theotretical Physics, Chinese Academy of Sciences, PR China Aaron HigueraDCI-UG Azarael Yebra PérezDCI-UG César Hernández AguayoDCI-UG Jaime Chagoya AlvarezDCI-UG Jonathan Rashid Rosique CampuzanoDCI-UG José Alfredo Soto ÁlvarezDCI-UG Juan Carlos De Haro SantosDCI-UG Luis Eduardo Medina MedranoDCI-UG Maria Fatima Rubio EspinozaDCI-UG Paulo Alberto Rodriguez HerreraDCI-UG Roberto Oziel Gutierrez CotaDCI-UG Rocha Moran Maria PaulinaDCI-UG Xareni Sanchez MonroyDCI-UG

Climate Past and Present: A Study on Glaciology of Himalayas in India

NASA Astrophysics Data System (ADS)

Shanmuganandan, S.

2003-04-01

Glaciers are moving bodies of ice and snow, which are normally present above the snow line. Glaciers and ice sheets are hundreds to more than one thousand meters thick and change significantly only over decades. On these longer time scales they can influence atmospheric circulation and global sea levels. Glaciers play an important role in maintaining ecosystem stability as they act as buffers and regulate the runoff water supply from high mountains to the plains during both dry and wet spells. The present study is an attempt to analyze the Climate of the Past and Present of the Himalayas with reference to study the glaciology. The study also attempted to use the remote sensed data to explore the past and present situation of glaciology of the Himalayas. Since mountain glaciology of Himalayas played a vital role and stand as an example to explore the possibility of the climate change that occurred from the past to the present and also to determine the status in the future. The Study was based on the secondary and primary data collected from available sources and also collected from various published records to document the evidences for the same. It was observed that the Himalayan glaciers account for about 70% of the world’s non-polar glaciers and affect the lives of millions of people in several countries: China, India, Pakistan, Afghanistan, Nepal and Bangladesh. Their runoff feeds two of the oldest rivers in the world, the Indus and the Ganges, whose tributaries carry precious water for 500 million people on the northern Indian plains. Most of the glaciers in the Himalayas are of a summer-accumulation type, that is major accumulation and ablation take place simultaneously during summer (Fujita et. al, 1997). The glaciers of the Himalayas include some of the longest outside the Polar Regions and reached their largest extent during the end of the last ice age (more than 20,000 years ago). The evidence of these large ice masses can be seen in 'U' shaped valleys

Stereoscopic observations from meteorological satellites

NASA Astrophysics Data System (ADS)

Hasler, A. F.; Mack, R.; Negri, A.

The capability of making stereoscopic observations of clouds from meteorological satellites is a new basic analysis tool with a broad spectrum of applications. Stereoscopic observations from satellites were first made using the early vidicon tube weather satellites (e.g., Ondrejka and Conover [1]). However, the only high quality meteorological stereoscopy from low orbit has been done from Apollo and Skylab, (e.g., Shenk et al. [2] and Black [3], [4]). Stereoscopy from geosynchronous satellites was proposed by Shenk [5] and Bristor and Pichel [6] in 1974 which allowed Minzner et al. [7] to demonstrate the first quantitative cloud height analysis. In 1978 Bryson [8] and desJardins [9] independently developed digital processing techniques to remap stereo images which made possible precision height measurement and spectacular display of stereograms (Hasler et al. [10], and Hasler [11]). In 1980 the Japanese Geosynchronous Satellite (GMS) and the U.S. GOES-West satellite were synchronized to obtain stereo over the central Pacific as described by Fujita and Dodge [12] and in this paper. Recently the authors have remapped images from a Low Earth Orbiter (LEO) to the coordinate system of a Geosynchronous Earth Orbiter (GEO) and obtained stereoscopic cloud height measurements which promise to have quality comparable to previous all GEO stereo. It has also been determined that the north-south imaging scan rate of some GEOs can be slowed or reversed. Therefore the feasibility of obtaining stereoscopic observations world wide from combinations of operational GEO and LEO satellites has been demonstrated. Stereoscopy from satellites has many advantages over infrared techniques for the observation of cloud structure because it depends only on basic geometric relationships. Digital remapping of GEO and LEO satellite images is imperative for precision stereo height measurement and high quality displays because of the curvature of the earth and the large angular separation of the

Cognitive and Behavioral Skills Exercises Completed by Patients with Major Depression During Smartphone Cognitive Behavioral Therapy: Secondary Analysis of a Randomized Controlled Trial.

PubMed

Furukawa, Toshi A; Horikoshi, Masaru; Fujita, Hirokazu; Tsujino, Naohisa; Jinnin, Ran; Kako, Yuki; Ogawa, Sei; Sato, Hirotoshi; Kitagawa, Nobuki; Shinagawa, Yoshihiro; Ikeda, Yoshio; Imai, Hissei; Tajika, Aran; Ogawa, Yusuke; Akechi, Tatsuo; Yamada, Mitsuhiko; Shimodera, Shinji; Watanabe, Norio; Inagaki, Masatoshi; Hasegawa, Akio

2018-01-11

tasks, engaged in different types of activities, and also filled in more cognitive restructuring worksheets than the latter. Activities such as "test-drive a new car," "go to a coffee shop after lunch," or "call up an old friend" were found to be particularly rewarding. All cognitive restructuring strategies were found to significantly decrease the distress level, with "What would be your advice to a friend who has a similar problem?" found more helpful than some other strategies. The CBT program offered via smartphone and connected to the remote server is not only effective in alleviating depression but also opens a new avenue in gathering information of what and how each participant may utilize the program. The activities and strategies found useful in this analysis will provide valuable information in brush-ups of the program itself and of mobile health (mHealth) in general. Japanese Clinical Trials Registry UMIN CTR 000013693; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ ctr_view.cgi?recptno=R000015984 (Archived by WebCite at http://www.webcitation.org/6u6pxVwik). ©Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa. Originally published in JMIR Mental Health (http://mental.jmir.org), 11.01.2018.

Latest climate changes in Romania :tornadoes

NASA Astrophysics Data System (ADS)

Pop, Elena

2014-05-01

Latest climate changes in Romania :tornadoes As climate change has been considered a research priority in the European Strategy for enduring development , I have done a detailed research with my students of the new climate change that has been going on in Romania for the past decade. More precisely I have studied together with my students the phenomenon of tornadoes that have seriously affected on some occasions some our our country's locations, such as Facaeni, in the county of Ialomita, in August 2002. A quite unusual phenomenon occurred on that location situated at 44.56 degrees northern latitude and at 27.89 degrees eastern longitude, that caused severe damage to the local environment and three persons lost their lives in the process, as well as other thirty people suffering from bad injuries. The magnitude of that strong phenomenon rose on the Fujita scale at level F3 which implied wing gusts between 252-300 km/ hour . A main cause of occurrence of such a severe weather was the difference in temperature of two huge air masses, one of Polar origin, and other coming from tropical latitudes . Their crossroads was on that precise territory of Romania. The duration of the worst part of the tornado path lasted only for two minutes, but the consequences of its passage were colossal : total destruction of 33 households, and other 395 were partially damaged, 1,000 people afflicted by the devastation and 100 acres of acacia tree forest ripped off the ground. The first ever recorded tornado phenomenon in Romania was around 1894-1896, considered at that time " a freak of nature" was seen as a cloud formation abnormality , an uncontrolled force of nature that had a huge impact , and at the same time, it vanished into "thin air " fast. The most affected areas in Romania by tornadoes are the south-eastern planes where the cloud formations can create fast columns of air rotating up to 500 km/hour. The local people compared the cloud funnels created on the planes to "serpents

Strong Coupling Gauge Theories in LHC ERA

NASA Astrophysics Data System (ADS)

Fukaya, H.; Harada, M.; Tanabashi, M.; Yamawaki, K.

2011-01-01

AdS/QCD, light-front holography, and the nonperturbative running coupling / Stanley J. Brodsky, Guy de Teramond and Alexandre Deur -- New results on non-abelian vortices - Further insights into monopole, vortex and confinement / K. Konishi -- Study on exotic hadrons at B-factories / Toru Iijima -- Cold compressed baryonic matter with hidden local symmetry and holography / Mannque Rho -- Aspects of baryons in holographic QCD / T. Sakai -- Nuclear force from string theory / K. Hashimoto -- Integrating out holographic QCD back to hidden local symmetry / Masayasu Harada, Shinya Matsuzaki and Koichi Yamawaki -- Holographic heavy quarks and the giant Polyakov loop / Gianluca Grignani, Joanna Karczmarek and Gordon W. Semenoff -- Effect of vector-axial-vector mixing to dilepton spectrum in hot and/or dense matter / Masayasu Harada and Chihiro Sasaki -- Infrared behavior of ghost and gluon propagators compatible with color confinement in Yang-Mills theory with the Gribov horizon / Kei-Ichi Kondo -- Chiral symmetry breaking on the lattice / Hidenori Fukaya [for JLQCD and TWQCD collaborations] -- Gauge-Higgs unification: Stable Higgs bosons as cold dark matter / Yutaka Hosotani -- The limits of custodial symmetry / R. Sekhar Chivukula ... [et al.] -- Higgs searches at the tevatron / Kazuhiro Yamamoto [for the CDF and D[symbol] collaborations] -- The top triangle moose / R. S. Chivukula ... [et al.] -- Conformal phase transition in QCD like theories and beyond / V. A. Miransky -- Gauge-Higgs unification at LHC / Nobuhito Maru and Nobuchika Okada -- W[symbol]W[symbol] scattering in Higgsless models: Identifying better effective theories / Alexander S. Belyaev ... [et al.] -- Holographic estimate of Muon g - 2 / Deog Ki Hong -- Gauge-Higgs dark matter / T. Yamashita -- Topological and curvature effects in a multi-fermion interaction model / T. Inagaki and M. Hayashi -- A model of soft mass generation / J. Hosek -- TeV physics and conformality / Thomas Appelquist -- Conformal

The 2009 Lindau Nobel Laureate Meeting: Martin Chalfie, Chemistry 2008

PubMed Central

Chalfie, Martin

2010-01-01

American Biologist Martin Chalfie shared the 2008 Nobel Prize in Chemistry with Roger Tsien and Osamu Shimomura for their discovery and development of the Green Fluorescent Protein (GFP). Martin Chalfie was born in Chicago in 1947 and grew up in Skokie Illinois. Although he had an interest in science from a young age-- learning the names of the planets and reading books about dinosaurs-- his journey to a career in biological science was circuitous. In high school, Chalfie enjoyed his AP Chemistry course, but his other science courses did not make much of an impression on him, and he began his undergraduate studies at Harvard uncertain of what he wanted to study. Eventually he did choose to major in Biochemistry, and during the summer between his sophomore and junior years, he joined Klaus Weber's lab and began his first real research project, studying the active site of the enzyme aspartate transcarbamylase. Unfortunately, none of the experiments he performed in Weber's lab worked, and Chalfie came to the conclusion that research was not for him. Following graduation in 1969, he was hired as a teacher Hamden Hall Country Day School in Connecticut where he taught high school chemistry, algebra, and social sciences for 2 years. After his first year of teaching, he decided to give research another try. He took a summer job in Jose Zadunaisky's lab at Yale, studying chloride transport in the frog retina. Chalfie enjoyed this experience a great deal, and having gained confidence in his own scientific abilities, he applied to graduate school at Harvard, where he joined the Physiology department in 1972 and studied norepinephrine synthesis and secretion under Bob Pearlman. His interest in working on C. elegans led him to post doc with Sydney Brenner, at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. In 1982 he was offered position at Columbia University. When Chalfie first heard about GFP at a research seminar given by Paul Brehm in

The 2009 Lindau Nobel Laureate meeting: Martin Chalfie, Chemistry 2008.

PubMed

Chalfie, Martin

2010-02-10

American Biologist Martin Chalfie shared the 2008 Nobel Prize in Chemistry with Roger Tsien and Osamu Shimomura for their discovery and development of the Green Fluorescent Protein (GFP). Martin Chalfie was born in Chicago in 1947 and grew up in Skokie Illinois. Although he had an interest in science from a young age--learning the names of the planets and reading books about dinosaurs--his journey to a career in biological science was circuitous. In high school, Chalfie enjoyed his AP Chemistry course, but his other science courses did not make much of an impression on him, and he began his undergraduate studies at Harvard uncertain of what he wanted to study. Eventually he did choose to major in Biochemistry, and during the summer between his sophomore and junior years, he joined Klaus Weber's lab and began his first real research project, studying the active site of the enzyme aspartate transcarbamylase. Unfortunately, none of the experiments he performed in Weber's lab worked, and Chalfie came to the conclusion that research was not for him. Following graduation in 1969, he was hired as a teacher Hamden Hall Country Day School in Connecticut where he taught high school chemistry, algebra, and social sciences for 2 years. After his first year of teaching, he decided to give research another try. He took a summer job in Jose Zadunaisky's lab at Yale, studying chloride transport in the frog retina. Chalfie enjoyed this experience a great deal, and having gained confidence in his own scientific abilities, he applied to graduate school at Harvard, where he joined the Physiology department in 1972 and studied norepinephrine synthesis and secretion under Bob Pearlman. His interest in working on C. elegans led him to post doc with Sydney Brenner, at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. In 1982 he was offered position at Columbia University. When Chalfie first heard about GFP at a research seminar given by Paul Brehm in 1989

Statistical Examination of Tornado Report and Warning Near-Storm Environments

NASA Astrophysics Data System (ADS)

Anderson-Frey, Alexandra K.

This study makes use of a 13-year dataset of 14,814 tornado events and 44,961 tornado warnings in the continental United States, along with near-storm environmental data associated with each of those tornado events and warnings, to build a methodology that can be used to create nuanced climatologies of near-storm environmental data. Two key parameter spaces are identified as being particularly useful in this endeavor: mixed-layer convective available potential energy (MLCAPE) versus 0-6-km vector shear magnitude (SHR6) and mixed-layer lifting condensation level (MLLCL) versus 0-1-km storm-relative helicity (SRH1). In addition, the Significant Tornado Parameter (STP) is identified as a useful composite parameter that can highlight near-storm environments that are particularly favorable for the development of significant tornadoes. Two particular statistical methods for the analysis and characterization of near-storm environments are described and applied: Kernel Density Estimation (KDE), which is applied to bulk (proximity soundinglike) parameter values associated with each event or warning, and Self-Organizing Maps (SOMs), which are applied to fully two-dimensional plots of STP in an area surrounding each event or warning. The KDE approach characterizes and identifies differences in the environments of tornadoes forming in quasi-linear convective systems versus those forming in right-moving supercells; specific environmental traits are also identified for different geographical regions, seasons, and times of day. Tornado warning performance is found to be best in environments with particularly large values of MLCAPE and SHR6. The early evening transition (EET) period is of particular interest: MLCAPE and MLLCL heights are in the process of falling, and SHR6 and SRH1 are in the process of increasing. Accordingly, tornadoes rated 2 or greater on the enhanced Fujita scale (EF2+) are also most common during the EET, probability of detection (POD) is relatively high

Radar observations of a tornado-spawning storm complex in Southeast Brazil and Meso-Eta forecasts of this extreme event

NASA Astrophysics Data System (ADS)

Held, Gerhard; Gomes, Jorge Luis; Gomes, Ana Maria

2014-05-01

During the early afternoon of 22 September 2013, severe storms, accompanied by large hail, damaging winds, heavy precipitation and intense lightning activity, devastated a region in the southeast State of São Paulo. Several extremely intense storm cells moved at up to 80 km/h east-southeastwards, ahead of a strong cold front approaching through Paraná, which created extremely unstable conditions that led to deep convection and overshooting towers up to 18 km. At least one of theses cells spawned a tornado when it reached the town of Taquarituba. The tornado traversed the town from south-southwest to north-northeast and was responsible for 63 people injured and two fatalities. Based on the damage reported, it was at least an F3 according to the Fujita scale. The objective of the present study is to characterize this severe thunderstorm event, using different types of data, and to evaluate the forecasts provided by the Meso-Eta model centered over Bauru. The pre-frontal and frontal convective cells were tracked throughout their life-time by IPMet's Doppler radars, which cover the western and central regions of the State São Paulo, as well as northern Paraná State. Radar volume scans, generated every 7,5 min, were processed with the TITAN (Thunderstorm Identification, Tracking, Analysis and Nowcasting) Software, yielding the following preliminary results: as the storm complex traversed the Paranapanema River, which forms the border between the two states, the cells intensified drastically and shortly before reaching the town of Taquarituba, that particular cell displayed extremely strong radial shear just above the cloud base (about -20 to +35 m/s), which led to the formation of a deep meso-cyclone, from which the tornado spawned and touched down at around 14:30 LT (LT=UT-3h). Cell properties calculated by TITAN showed a drastic increase of VIL (Vertically Integrated Liquid water content) from 13:52 LT (7,9 kg/m2) to a maximum of 61,8 kg/m2 at 14:15 LT. From 14

[Preventive measures against tuberculosis in working facilities and companies].

PubMed

Suzuki, Kiminori; Satou, Ken

2007-03-01

The health care program in working facilities and companies have played a significant part in prevention of tuberculosis. However, the ordinary national tuberculosis survey policy was abolished in April, 2005 and the tuberculosis survey for salary-earners is on the brink of drastic change. In this symposium the current status of the prevailing survey of tuberculosis in working facilities and companies was reviewed and the future direction of the tuberculosis survey in comparison to that in lung cancer survey was discussed. 1. Epidemiological trends of tuberculosis from the tuberculosis surveillance data: Masako OHMORI (Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association). The estimated rate of tuberculosis case discovery by periodical mass screening in the working facilities was 0.033% and it was higher than that in general adult population. The detection rate of tuberculosis in nurses who suffered from tuberculosis reached 40.4% by an aid of mass X-ray screening and 8.7% by contact tracing. The risk of onset of the disease was 4.3 times higher nurses than in general at the same years of age. The importance of infection control measures in the medical facilities was emphasized. 2. Current status and problems in tuberculosis control in a large-sized company: Yusuke NAKAOKA (Department of Occupational Health, Osaka Railway Hospital, West Japan Railway Company). Some preventive modalities against TB such as periodical medical check-up and awareness programs have been done for the purpose of prevention in our company. The prevalence of the disease has significantly reduced in number. The specific circumstances in large-sized company should be taken into consideration, and it is important for company workers and health professionals to recognize their roles in preventing the infectious disease. 3. Are there any differences between clinical cases and control people working for small-sized companies in the onset of tuberculosis?: Osamu NAKASHIMA, Kohei

Chronicle of a Death Foretold

NASA Astrophysics Data System (ADS)

2007-05-01

more dust production and mass ejection: in these phases indeed the amount of dust is significantly higher than in the others. After this intense matter production and ejection the star continues its pulsation and when it reaches the maximum luminosity, it displays a much more expanded dust shell. This clearly supports a strong connection between the Mira pulsation and the dust production and expulsion. Furthermore, the astronomers found that grains of aluminum oxide - also called corundum - constitute most of S Ori's dust shell: the grain size is estimated to be of the order of 10 millionths of a centimetre, that is one thousand times smaller than the diameter of a human hair. "We know one chapter of the secret life of a Mira star, but much more can be learned in the near future, when we add near-infrared interferometry with the AMBER instrument on the VLTI to our (already broad) observational approach," said Wittkowski. More Information The research presented here is reported in a paper in press in the journal Astronomy and Astrophysics ("The Mira variable S Ori: Relationships between the photosphere, molecular layer, dust shell, and SiO maser shell at 4 epochs", by M. Wittkowski et al.). It is available in PDF format from the publisher's web site. The team consists of Markus Wittkowski (ESO), David A. Boboltz (U.S. Naval Observatory, USA), Keiichi Ohnaka and Thomas Driebe (MPIfR Bonn, Germany), and Michael Scholz (University of Heidelberg, Germany and University of Sydney, Australia).

Preface: LEHTSC2007

NASA Astrophysics Data System (ADS)

Oyanagi, Hiroyuki

2008-03-01

also appreciate exhibitors of Cryoportal 2007 for promoting the conference and financial support. The efforts of Atsuyuki Fukano, Zhyu Sun and Changjing Zhang for arranging the conference site and audio-visual equipment are appreciated. Also thanks are due to Masayo Fujita for maintaining the secretariat and Masako Oyanagi for coordinating social events. Lastly we wish to express our sincere thanks to the editorial team of IOP Publishing. Hiroyuki Oyanagi Chairman of LEHTSC2007

Condensed Matter Theories - Volume 22

NASA Astrophysics Data System (ADS)

Reinholz, Heidi; Röpke, Gerd; de Llano, Manuel

2007-09-01

pt. A. Fermi liquids. Pressure comparison between the spherical cellular model and the Thomas-Fermi model / G.A. Baker, Jr. Pair excitations and vertex corrections in Fermi fluids and the dynamic structure function of two-dimension 3He / H.M. Böhm, H. Godfrin, E. Krotscheck, H.J. Lauter, M. Meschke and M. Panholzer. Condensation of helium in wedges / E.S. Hernádez ... [et al.]. Non-Fermi liquid behavior from the Fermi-liquid approach / V.A. Khodel ... [et al.]. Theory of third sound and stability of thin 3He-4He superfluid films / E. Krotscheck and M.D. Miller. Pairing in asymmetrical Fermi systems / K.F. Quader and R. Liao. Ground-state properties of small 3He drops from quantum Monte Carlo simulations / E. Sola, J. Casulleras and J. Boronat. Ground-state energy and compressibility of a disordered two-dimensional electron gas / Tanatar ... [et al.]. Quasiexcitons in photoluminescence of incompressible quantum liquids / A. Wójs, A.G ladysiewicz and J.J. Quinn -- pt. B. Bose liquids. Quantum Boltzmann liquids / K.A. Gernoth, M L. Ristig and T. Lindenau. Condensate fraction in the dynamic structure function of Bose fluids / M. Saarela, F. Mazzanti and V. Apaja -- pt. C. Strongly-correlated electronic systems. Electron gas in high-field nanoscopic transport: metallic carbon nanotubes / F. Green and D. Neilson. Evolution and destruction of the Kondo effect in a capacitively coupled double dot system / D.E. Logan and M.R. Galpin. The method of increments-a wavefunction-based Ab-Initio correlation method for solids / B. Paulus. Fractionally charged excitations on frustrated lattices / E. Runge, F. Pollmann and P. Fulde. 5f Electrons in actinides: dual nature and photoemission spectra / G. Zwicknagl -- pt. D. Magnetism. Magnetism in disordered two-dimensional Kondo-Necklace / W. Brenig. On the de Haas-can Alphen oscillation in 2D / S. Fujita and D.L. Morabito. Dynamics in one-dimensional spin systems-density matrix reformalization group study / S. Nishimoto and M

[The clinical application of quantiferon TB-2G: its usefulness and limitations].

PubMed

Sato, Shigeki; Nagai, Hideaki

2011-02-01

compromised hosts is essential for TB control, but T cell assay might be influenced by the degree of cell-mediated immunosuppression. The relationship between immunocompetence and specific interferon (IFN)-gamma response in whole blood QuantiFERON-TB Gold (QFT) is uncertain. Immune-related clinical indicators associated with the degree of antigen-specific IFN-gamma production were analysed using a large immunologically-unselected population with obvious TB infection. The absolute number of blood lymphocyte in TB patients was significantly associated with specific IFN-gamma production in a linear regression model. Sensitivity of 2 IFN-gamma Release Assays, QFT and ELISPOT, partly depends on peripheral lymphocyte counts. At low lymphocyte count conditions, ELISPOT assay is superior to whole blood QFT for detecting tuberculosis infection. (4) QuantiFERON TB-2G among staffs in the hospitals of Nationao Hospital Organization: Susumu OGURI, Chihiro NISHIO, Kensuke SUMI, Masayoshi MINAGUCHI, Tomomasa TSUBOI, Atuo SATOU, Osamu TOKUNAGA, Takeshi MIYAMOMAE, Takuya KURASAWA (National Hospital Organization Minami-Kyoto National Hospital) To investigate the infection rate of tuberculosis among staffs working in the hospitals of NHO. Questionnaires were sent to the hospitals and the responses were analyzed. Among the staffs working in the hospitals with tuberculosis wards, positive rate of QuantiFERON TB-2G was 6.9%, probable positive rate was 5.6%. On the other hand, among the staffs working in the hospitals without tuberculosis wards, positive rate was 4.4%, probable positive rate was 3.9%. It is necessary to monitor the infection rate among hospital staffs.

EDITORIAL: Message from the Editor Message from the Editor

NASA Astrophysics Data System (ADS)

Thomas, Paul

2011-01-01

Index. The journal depends entirely on its authors and referees and so I would like to thank them all for their work in 2010 and look forward to a continuing, successful collaboration in 2011. Refereeing The Nuclear Fusion editorial office understands how much effort is required of our referees. The Editorial Board decided that an expression of thanks to our most loyal referees is appropriate and so, since January 2005, we have been offering the top ten most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. This year, two of the top referees have reviewed four or more manuscripts in the period November 2009 to November 2010 and provided particularly detailed advice to the authors. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their special issues is also excluded from consideration. The following people have been selected: Osamu Naito, Japan Atomic Energy Agency, Naka, Japan Masahiro Kobayashi, National Institute for Fusion Science, Toki, Japan Duccio Testa, Lausanne Federal Polytechnic University, Switzerland Vladimir Pustovitov, Russian Research Centre, Kurchatov Insitute, Russia Christopher Holland, University of California at San Diego, USA Yuri Gribov, ITER International Organisation, Cadarache, France Eriko Jotaki, Kyushu University, Japan Sven Wiesen, Jülich Research Centre, Germany Viktor S. Marchenko, Ukraine National Academy of Sciences, Ukraine Richard Stephens, General Atomics, USA In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2010. Our thanks to them! Authors The winner of the 2010 Nuclear Fusion Award was J.E. Rice et al for the paper entitled 'Inter-machine comparison of

EDITORIAL: Nanotechnology in vivo Nanotechnology in vivo

NASA Astrophysics Data System (ADS)

Demming, Anna

2010-04-01

Since the development of x-rays the ability to image inside our bodies has provided medicine with a potent diagnostic tool, as well as fascinating us with the eerie evidence of our mechanistic mortality. In December 2008 Osamu Shimomura, Martin Chalfie and Roger Y Tsien received a Nobel Prize for the discovery and development of the green fluorescent protein. The award recognised a new discovery that further facilitated our abilities to follow cellular activities and delve deeper into the workings of living organisms. Since the first observation of green fluorescent protein in jelly fish over thirty years ago, quantum dots have emerged as a potential alternative tool for imaging [1]. The advantages of quantum dots over organic dyes and fluorescent proteins include intense luminescence, high molar extinction coefficient, resistance to photobleaching, and broad excitation with narrow emission bands. However, one drawback for biological applications has been the layer of hydrophobic organic ligands often present at the surface as a result of the synthesis procedures. One solution to improve the solubility of quantum dots has been to conjugate them with a hydrophilic substance, as reported by Nie et al [2]. Chitosan is a hydrophilic, non-toxic, biocompatible and biodegradable substance and has been conjugated with quantum dots such as CdSe-ZnS [2] for bioassays and intracellular labelling. As well as luminescence, different nanoparticles present a variety of exceptional properties that render them useful in a range of bio applications, including MRI, drug delivery and cancer hyperthermia therapy. The ability to harness these various attributes in one system was reported by researchers in China, who incorporated magnetic nanoparticles, fluorescent quantum dots and pharmaceutical drugs into chitosan nanoparticles for multifunctional smart drug delivery systems [3]. More recently silicon quantum dots have emerged as a less cytotoxic alternative to CdSe for bio

PREFACE: The Sixth International Conference on Gravitation & Cosmology

NASA Astrophysics Data System (ADS)

Date, Ghanashyam; Souradeep, Tarun

2008-07-01

Subhabrata Majumdar Cosmology with Clusters David Langlois Cosmological Perturbations from Inflation John Conklin The Gravity Probe B Experiment and Results B. Sathyaprakash Physics, Astrophysics and Cosmology with Gravitational Waves Rana Adhikari Survey of Gravitational Waves Experiments John Baker Survey of Numerical Relativity Results Maria Alessandra Papa Data Analysis for Gravitational Wave Detectors Alessandra Buonanno Interfacing analytical and numerical relativity in modeling binary black hole coalescences Andy Fabian X-ray detection of spinning black hole Alejandro Corichi Black Holes in Loop Quantum Gravity Madhavan Varadarajan Black Hole Information Loss Puzzle in LQG Parampreet Singh Big Bang Singularity Resolution in Loop Quantum Cosmology Sumit Das Cosmological Singularities in String Theory and Gauge-Gravity Duality Samir Mathur What do black holes tell us about the state of the early Universe? Martin Reuter Asymptotic Safety in Quantum Gravity Keiichi Maeda Beyond the Einstein-Hilbert Action Jurgen Ehlers Concluding Remarks

EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010)

NASA Astrophysics Data System (ADS)

Takahashi, M.; Saito, H.

2011-02-01

Yanagihara, Yuta Toyoda and Eiji Kita Monte Carlo simulations of the magnetocaloric effect in magnetic Ni-Mn-X (X = Ga, In) Heusler alloys V D Buchelnikov, V V Sokolovskiy, S V Taskaev, V V Khovaylo, A A Aliev, L N Khanov, A B Batdalov, P Entel, H Miki and T Takagi Changes in electronic states and magnetic free energy in La1-zCez(FexSi1-x)13 magnetic refrigerants A Fujita, S Fujieda and K Fukamichi Garnet composite films with Au particles fabricated by repetitive formation for enhancement of Faraday effect H Uchida, Y Mizutani, Y Nakai, A A Fedyanin and M Inoue Control of magnetic domain wall displacement using spin current in small in-plane magnetic field in Permalloy nanowires Yoshihiko Togawa, Takashi Kimura, Ken Harada, Akira Tonomura and Yoshichika Otani Magnetic-field tunable transmittance in a ferrofluid-filled silicon nitride photonic crystal slab H M Lee, L Horng and J C Wu Evaluation of a miniature magnetostrictive actuator using Galfenol under tensile stress Toshiyuki Ueno, Hidemitsu Miura and Sotoshi Yamada Sub-nm resolution depth profiling of the magnetic structure of thin films by the depth-resolved x-ray magnetic circular dichroism technique K Amemiya and M Sakamaki

VLBA Teams With Optical Interferometer to Study Star's Layers

NASA Astrophysics Data System (ADS)

2007-05-01

speed of about 10 km/s. The multi-wavelength analysis indicates that near the minimum there is more dust production and mass ejection: in these phases indeed the amount of dust is significantly higher than in the others. After this intense matter production and ejection the star continues its pulsation and when it reaches the maximum luminosity, it displays a much more expanded dust shell. This clearly supports a strong connection between the Mira pulsation and the dust production and expulsion. Furthermore, the astronomers found that grains of aluminum oxide - also called corundum - constitute most of S Ori's dust shell: the grain size is estimated to be of the order of 10 millionths of a centimetre, that is one thousand times smaller than the diameter of a human hair. "We know one chapter of the secret life of a Mira star, but much more can be learned in the near future, when we add near-infrared interferometry with the AMBER instrument on the VLTI to our (already broad) observational approach," said Wittkowski. More Information The research presented here is reported in a paper in press in the journal Astronomy and Astrophysics ("The Mira variable S Ori: Relationships between the photosphere, molecular layer, dust shell, and SiO maser shell at 4 epochs", by M. Wittkowski et al.). It is available in PDF format from the publisher's web site. The team consists of Markus Wittkowski (ESO), David A. Boboltz (U.S. Naval Observatory, USA), Keiichi Ohnaka and Thomas Driebe (MPIfR Bonn, Germany), and Michael Scholz (University of Heidelberg, Germany and University of Sydney, Australia). Notes A maser is the microwave equivalent to a laser, which emits visible light. A maser emits powerful microwave radiation instead and its study requires radio telescopes. An astrophysical maser is a naturally occurring source of stimulated emission that may arise in molecular clouds, comets, planetary atmospheres, stellar atmospheres, or from various conditions in interstellar space. ESO

The 13th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2013)

NASA Astrophysics Data System (ADS)

Mitcheson, Paul; Beeby, Steve

2013-12-01

Institute of Technology, USA Ryutaro Maeda, National Institute of Advanced Industrial Science and Technology, Japan Kazusuke Maenaka, University of Hyogo, Japan Paul Mitcheson, Imperial College London, UK Albert Pisano, UC San Diego, USA Susumu Sugiyama, Ritsumeikan University, Japan Yuju Suzuki, University of Tokyo, Japan Shuji Tanaka, Tohoku University, Japan Miwako Waga, Susano Berkeley LLC, Japan Peter Woias, University Freiburg IMTEK, Germany Technical Program Committee David Arnold, University of Florida, USA Seiji Aoyagi, Kansai University, Japan Skandar Basrour, Tima Laboratory, France Philippe Basset, Université Paris Est/ESIEE Paris, France Mustafa Ilker Beyaz, Antalya International University, Turkey Danick Briand, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland Steve Burrow, University of Bristol, UK Luc Fréchette, University of Sherbrooke, Canada Takayuki Fujita, University of Hyogo, Japan Florian Herrault, Georgia Institute of Technology, USA Andrew Holmes, Imperial College London, UK Hanseup Kim, University of Utah, USA Seong-Hyok Kim, Georgia Institute of Technology, USA Sejin Kwon, KAIST, South Korea Carol Livermore, Northeastern University, USA Matthew McCarthy, Drexel University, USA Jae Park, Kwangwoon University, South Korea Paul Ronney, University of Southern California, USA Nico de Rooij, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland Yuji Suzuki, University of Tokyo, Japan Shuji Tanaka, Tohoku University, Japan Luis Velasque-Garcia, Massachusetts Institute of Technology, USA Huib Visser, Imec Netherlands Ruud Vullers, Imec, Netherlands C Mike Waits, US Army Research Laboratory, USA Xiaohong Wang, Tsinghua University, China David Yates, Imperial College London, UK Local Organising Committee Dibin Zhu, University of Southampton, UK Alex Weddell, University of Southampton, UK Tzern Toh, Imperial College London, UK Michail Kiziroglou, Imperial College London, UK Christopher Kwan, Imperial College London, UK

[Patient-centered medicine for tuberculosis medical services].

PubMed

Fujita, Akira; Narita, Tomoyo

2012-12-01

necessary patient information among the relevant parties. The regional care pathway was developed by the Tobu Public Health Center. It is currently being used by several other public health centers in Hiroshima. Utilization of these two pathways has resulted in improved adherence, treatment being offered at local clinics, shorter hospitalization and better treatment outcomes. 2. Patient-centered DOTS in Funabashi-city: Akiko UOZUMI (Funabashi-city Public Health Center) In Funabashi-city, all TB patients, including those with LTBI, are treated under DOTS which recognizes and tries to accommodate the various different needs of each individual patient. For example, various types of DOTS are offered, such as pharmacy-based DOTS and DOTS supported by caregivers of nursing homes. This enables public health nurses to take into consideration both the results of risk assessment and convenience for the patient, and choose DOTS which most effectively support the patient. Furthermore, DOTS in principle is offered face-to-face, so that DOTS providers may not only build relationship of trust with the patient, but also to collect and analyze the necessary information regarding the patient and respond timely when problems arise. Such effort has directly contributed to improved default and treatment rate. 3. Hospital DOTS and clinical path for the treatment of tuberculosis: Kentaro SAKASHITA, Akira FUJITA (Tokyo Metropolitan Tama Medical Center) We introduced a version of hospital DOTS at Tama Medical Center (formerly Fuchu Hospital) in 2004. As part of this three-stage version, patients are allowed to progress to the next stage if they meet the step-up criteria. Following the introduction of this hospital DOTS, the occurrence of drug administration-related incidents decreased and support for patient adherence became easier for health care workers than before. In 2006, we developed a clinical path based on this hospital DOTS with consistent eligibility criteria for patients. This clinical

Proceedings of the 8th International Symposium on Foundations of Quantum Mechanics in the Light of New Technology

NASA Astrophysics Data System (ADS)

Ishioka, Sachio; Fujikawa, Kazuo

2006-06-01

Preface -- Committees -- Opening address / H. Fukuyama -- Welcoming address / N. Osakabe -- Special lecture. Albert Einstein: opportunity and perception / C. N. Yang -- Quantum information and entanglement. Quantum optics with single atoms and photons / H. J. Kimble. Quantum information system experiments using a single photon source / Y. Yamamoto. Quantum communication and quantum computation with entangled photons / A. Zeilinger. High-fidelity quantum teleportation and a quantum teleportation network for continuous variables / N. Takei, A. Furusawa. Long lived entangled states / H. Häffner ... [et al.]. Quantum non-locality using tripartite entanglement with non-orthogonal states / J. V. Corbett, D. Home. Quantum entanglement and wedge product / H Heydari. Analysis of the generation of photon pairs in periodically poled lithium niobate / J. Söderholm ... [et al.]. Generation of entangled photons in a semiconductor and violation of Bell's inequality / G. Oohata, R. Shimizu, K. Edamatsu -- Quantum computing. Decoherence of a Josephson junction flux qubit / Y. Nakamura ... [et al.]. Spectroscopic analysis of a candidate two-qubit silicon quantum computer in the microwave regime / J. Gorman, D. G. Hasko, D. A. Williams. Berry phase detection in charge-coupled flux-qubits and the effect of decoherence / H. Nakano ... [et al.]. Locally observable conditions for the successful implementation of entangling multi-qubit quantum gates / H. F. Hofmann, R. Okamoto, S. Takeuchi. State control in flux qubit circuits: manipulating optical selection rules of microwave-assisted transitions in three-level artificial atoms / Y.-X. Liu ... [et al.]. The effect of local structure and non-uniformity on decoherence-free states of charge qubits / T. Tanamoto, S. Fujita. Entanglement-assisted estimation of quantum channels / A. Fujiwara. Superconducting quantum bit with ferromagnetic [symbol]-Junction / T. Yamashita, S. Takahashi, S. Maekawa. Generation of macroscopic Greenberger

PREFACE Preface

NASA Astrophysics Data System (ADS)

Takahashi, Migaku; Saito, Hitoshi; Yoshimura, Satoru; Takanashi, Koki; Sahashi, Masashi; Tsunoda, Masakiyo

2011-01-01

23 countries, with about 40 percent of participants attending from overseas (see figure). The program involved 4 plenary talks (45 minutes each), 37 invited talks (30 minutes), 85 contributed talks (15 minutes), and 352 posters. Pie chart Organizing Committee of ISAMMA 2010 M TakahashiTohoku Univ., Japan, Chairman K TakanashiTohoku Univ., Japan, Chair of the Program Committee H SaitoAkita Univ., Japan, Chair of the Publication Committee M SahashiTohoku Univ., Japan, Chair of the Treasury Committee M TsunodaTohoku Univ., Japan, General Secretary H AkinagaAIST, Japan H FukunagaNagasaki Univ., Japan K HonoNIMS, Japan S IshioAkita Univ., Japan S IwataNagoya Univ., Japan K NakagawaNihon Univ., Japan S NakagawaTokyo Inst. of Tech., Japan T OnoKyoto Univ., Japan Y SuzukiOsaka Univ., Japan M TanakaEhime Univ., Japan T Tanaka Univ. of Tokyo, Japan Program Committee of ISAMMA 2010 K TakanashiTohoku Univ., Japan, ChairS MizukamiTohoku Univ., Japan M MizuguchiTohoku Univ., Japan, Vice-chairH NaganumaTohoku Univ., Japan M DoiTohoku Univ., JapanS NakagawaTokyo Inst. of Tech., Japan A FujitaTohoku Univ., JapanK NakamuraTohoku Univ., Japan K IshiyamaTohoku Univ., JapanK OnoKEK, Japan T KatoNagoya Univ., JapanT OnoKyoto Univ., Japan T KawagoeOsaka Pref. Univ.of Edu., JapanF SatoTohoku Univ., Japan O KitakamiTohoku Univ., JapanM ShiraiTohoku Univ., Japan Y KitamotoTokyo Inst. of Tech., JapanS SugimotoTohoku Univ., Japan F MatsukuraTohoku Univ., JapanM YamaguchiTohoku Univ., Japan C MitsumataHitachi Metals, Japan Publication Committee of ISAMMA 2010 H SaitoAkita Univ., Japan, ChairS MitaniNIMS, Japan S YoshimuraAkita Univ., Japan, Vice-chairH MuraokaTohoku, Japan Y AndoTohoku Univ., JapanM NakanoNagasaki Univ., Japan J AriakeAIT, JapanR NakataniOsaka Univ., Japan H AsanoNagoya Univ., JapanK O'GradyUniv. of York, UK M FutamotoChuo Univ., JapanA SakumaTohoku Univ., Japan J HayakawaHitachi, ARL, JapanT SatoKeio Univ., Japan T HondaKyushu Inst. of Tech., JapanT SatoShinshu Univ., Japan M

Proceedings of the 9th International Symposium on Foundations of Quantum Mechanics in the Light of New Technology

NASA Astrophysics Data System (ADS)

Ishioka, Sachio; Fujikawa, Kazuo

2009-06-01

detection / T. Tanamoto, Y. Nishi, S. Fujita. Geometric universal single qubit operation of cold two-level atoms / H. Imai, A. Morinaga. Entanglement dynamics in quantum Brownian motion / K. Shiokawa. Coupling superconducting flux qubits using AC magnetic flxues / Y. Liu, F. Nori. Entanglement purification using natural spin chain dynamics and single spin measurements / K. Maruyama, F. Nori. Experimental analysis of spatial qutrit entanglement of down-converted photon pairs / G. Taguchi ... [et al.]. On the phase sensitivity of two path interferometry using path-symmetric N-photon states / H. F. Hofmann. Control of multi-photon coherence using the mixing ratio of down-converted photons and weak coherent light / T. Ono, H. F. Hofmann -- Mechanical properties of confined geometry. Rattling as a novel anharmonic vibration in a solid / Z. Hiroi, J. Yamaura. Micro/nanomechanical systems for information processing / H. Yamaguchi, I. Mahboob -- Precise measurements. Electron phase microscopy for observing superconductivity and magnetism / A. Tonomura. Ratio of the Al[symbol] and Hg[symbol] optical clock frequencies to 17 decimal places / W. M. Itano ... [et al.]. STM and STS observation on titanium-carbide metallofullerenes: [symbol] / N. Fukui ... [et al.]. Single shot measurement of a silicon single electron transistor / T. Ferrus ... [et al.]. Derivation of sensitivity of a Geiger mode APDs detector from a given efficiency to estimate total photon counts / K. Hammura, D. A. Williams -- Novel properties in nano-systems. First principles study of electroluminescence in ultra-thin silicon film / Y. Suwa, S. Saito. First principles nonlinear optical spectroscopy / T. Hamada, T. Ohno. Field-induced disorder and carrier localization in molecular organic transistors / M. Ando ... [et al.]. Switching dynamics in strongly coupled Josephson junctions / H. Kashiwaya ... [et al.]. Towards quantum simulation with planar coulomb crystals / I. M. Buluta, S. Hasegawa -- Fundamental problems in