Calomme, M; Geusens, P; Demeester, N; Behets, G J; D'Haese, P; Sindambiwe, J B; Van Hoof, V; Vanden Berghe, D
2006-04-01
Silicon (Si) deficiency in animals results in bone defects. Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements. The effect of ch-OSA supplementation was investigated on bone loss in aged ovariectomized (OVX) rats. Female Wistar rats (n = 58, age 9 months) were randomized in three groups. One group was sham-operated (sham, n = 21), and bilateral OVX was performed in the other two groups. OVX rats were supplemented orally with ch-OSA over 30 weeks (OVX1, n = 20; 1 mg Si/kg body weight daily) or used as controls (OVX0, n = 17). The serum Si concentration and the 24-hour urinary Si excretion of supplemented OVX rats was significantly higher compared to sham and OVX controls. Supplementation with ch-OSA significantly but partially reversed the decrease in Ca excretion, which was observed after OVX. The increase in bone turnover in OVX rats tended to be reduced by ch-OSA supplementation. ch-OSA supplementation increased significantly the femoral bone mineral content (BMC) in the distal region and total femoral BMC in OVX rats, whereas lumbar BMC was marginally increased. Femoral BMD was significantly increased at two sites in the distal region in OVX rats supplemented with ch-OSA compared to OVX controls. Total lumbar bone mineral density was marginally increased by ch-OSA supplementation. In conclusion, ch-OSA supplementation partially prevents femoral bone loss in the aged OVX rat model.
Wickett, R R; Kossmann, E; Barel, A; Demeester, N; Clarys, P; Vanden Berghe, D; Calomme, M
2007-12-01
The appearance of hair plays an important role in people's overall physical appearance and self-perception. Silicon (Si) has been suggested to have a role in the formation of connective tissue and is present at 1-10 ppm in hair. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to improve skin microrelief and skin mechanical properties in women with photoaged skin. The effect of ch-OSA on hair was investigated in a randomized, double blind, placebo-controlled study. Forty-eight women with fine hair were given 10 mg Si/day in the form of ch-OSA beadlets (n = 24) or a placebo (n = 24), orally for 9 months. Hair morphology and tensile properties were evaluated before and after treatment. Urinary silicon concentration increased significantly in the ch-OSA supplemented group but not in the placebo group. The elastic gradient decreased in both groups but the change was significantly smaller in the ch-OSA group (-4.52%) compared to placebo group (-11.9%). Break load changed significantly in the placebo group (-10.8%) but not in the ch-OSA supplemented group (-2.20%). Break stress and elastic modulus decreased in both groups but the change was smaller in the ch-OSA group. The cross sectional area increased significantly after 9 months compared to baseline in ch-OSA supplemented subjects but not in the placebo group. The change in urinary silicon excretion was significantly correlated with the change in cross sectional area. Oral intake of ch-OSA had a positive effect on tensile strength including elasticity and break load and resulted in thicker hair.
Barel, A; Calomme, M; Timchenko, A; De Paepe, K; Paepe, K De; Demeester, N; Rogiers, V; Clarys, P; Vanden Berghe, D
2005-10-01
Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, "none=0, severe=3") brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: -16%; Rm: -19%; Rz: -8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.
Teachers Learning from Each Other in Japan through Jugyou Kenkyu.
ERIC Educational Resources Information Center
Arani, Mohammad Reza Sarkar
Many school-based inservice teacher training programs are available to Japanese teachers, including observing classes in other schools, inviting parents to observe and provide feedback, and conducting collaborative research on the teaching-learning process (Jugyou Kenkyu). This article highlights Jugyou Kenkyu, which is based on three steps…
Geusens, Piet; Pavelka, Karel; Rovensky, Jozef; Vanhoof, Johan; Demeester, Nathalie; Calomme, Mario; Vanden Berghe, Dirk
2017-01-05
The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA). In a multicenter, double-blind, placebo-controlled study, 211 patients with knee OA (Kellgren and Lawrence grade II or III) and moderate to moderately severe pain were randomly allocated to ch-OSA or placebo for 12 weeks. The primary outcome was the change in the WOMAC pain subscale from baseline to week 12. Secondary outcomes were changes from baseline to week 12 in WOMAC total, WOMAC stiffness, WOMAC physical function, Subject Global Assessment and levels of cartilage degradation biomarkers C-terminal telopeptide of collagen type II (CTX-II) and cartilage oligomeric matrix protein (COMP). Pre-specified subgroup analyses included the effect of gender. A total of 166 (120 women, 46 men) patients were included in the analysis (87 and 79 in the ch-OSA and placebo group, respectively). In the total study population, no differences were observed between the two treatment groups for the different outcomes but significant treatment x gender interactions were found. In men taking ch-OSA, a significant improvement in WOMAC total, WOMAC stiffness and WOMAC physical function as well as a lower increase in biomarker levels of cartilage degradation was observed, but not in women. The change in WOMAC pain showed a similar positive trend in men taking ch-OSA. After 12 weeks of treatment, no effect was found of ch-OSA in the total study population on clinical parameters and biomarkers, but a gender interaction was observed. In men, ch-OSA was found effective in reducing symptoms of knee OA, which was associated with a slight but significant reduction of biomarkers that are related to cartilage degradation. The study was registered retrospectively: ISRCTN88583133 . Registration date: 2015-10-07.
ERIC Educational Resources Information Center
Masami, Matoba; Reza, Sarkar Arani M.
2005-01-01
This paper tries to present a careful analysis of current trends and challenges to importing Japanese model of teachers' professional development. The objective is to examine what "we" can learn from Japanese approach to improving instruction, especially "Jugyou Kenkyu" (Lesson Study) as a collaborative research on the…
Spector, Tim D; Calomme, Mario R; Anderson, Simon H; Clement, Gail; Bevan, Liisa; Demeester, Nathalie; Swaminathan, Rami; Jugdaohsingh, Ravin; Berghe, Dirk A Vanden; Powell, Jonathan J
2008-01-01
Background Mounting evidence supports a physiological role for silicon (Si) as orthosilicic acid (OSA, Si(OH)4) in bone formation. The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of bone turnover and bone mineral density (BMD) was investigated in a double-blind placebo-controlled trial. Methods Over 12-months, 136 women out of 184 randomized (T-score spine < -1.5) completed the study and received, daily, 1000 mg Ca and 20 μg cholecalciferol (Vit D3) and three different ch-OSA doses (3, 6 and 12 mg Si) or placebo. Bone formation markers in serum and urinary resorption markers were measured at baseline, and after 6 and 12 months. Femoral and lumbar BMD were measured at baseline and after 12 months by DEXA. Results Overall, there was a trend for ch-OSA to confer some additional benefit to Ca and Vit D3 treatment, especially for markers of bone formation, but only the marker for type I collagen formation (PINP) was significant at 12 months for the 6 and 12 mg Si dose (vs. placebo) without a clear dose response effect. A trend for a dose-corresponding increase was observed in the bone resorption marker, collagen type I C-terminal telopeptide (CTX-I). Lumbar spine BMD did not change significantly. Post-hoc subgroup analysis (baseline T-score femur < -1) however was significant for the 6 mg dose at the femoral neck (T-test). There were no ch-OSA related adverse events observed and biochemical safety parameters remained within the normal range. Conclusion Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial effect on bone collagen compared to Ca/Vit D3 alone which suggests that this treatment is of potential use in osteoporosis. NTR 1029 PMID:18547426
ERIC Educational Resources Information Center
Matoba, Masami; Sarkar Arani Mohammed Reza
2006-01-01
In this paper, we examine how journal and ethnography field notes in Jugyou Kenkyu (lesson study) help teachers to understand the diverse range of talents and abilities of their students. Especially, we focus on how ethnography field note and reflective papers (karate) help teachers to change their assumptions about student learning. The data…
ERIC Educational Resources Information Center
Bulletin, 1969
1969-01-01
This document is an English-language abstract (approximately 1,500 words) of a series of research papers on the selection of college and university students. One paper compared the scores gained by three different types of entrants to six universities attracting applicants of high quality. It was found that a candidate has almost no chance of…
ONRASIA Scientific Information Bulletin. Volume 17, Number 2, Apr-Jun 1992
1992-06-01
the Physics Division, Research 7. K Yagi, H . Onuki , S. Sugiyama, Department. Dr. Rehn received his andT. Yamazaki,BunkyoKenkyu 40(5) B.A. in physics at...Pittsburgh in 1962. Aftercomplet- 8. T. Saito, K Katori, M. Nishi, and ing his thesis research in nuclear H . Onuki , Rev. Sci. Instru. 60, 2303...quadrupole resonance studies of para (1989); T. Saito, K Katori, and H . Onuki , dichlorobenzene and related mate- Physica Scripta 41,783 (1990). rials, Dr. Rchn
The Relationship between Subclinical Asperger's Syndrome and Frontotemporal Lobar Degeneration
Midorikawa, Akira; Kawamura, Mitsuru
2012-01-01
Background/Aims The existence of the behavioral variant of frontotemporal dementia (bv-FTD), including senile Asperger's syndrome (AS), has been proposed. However, there are no empirical case reports to support the proposal. In this report, we present 3 patients who showed symptoms of bv-FTD and demonstrated signs of autistic spectrum disorder, especially AS. Methods We evaluated 3 subjects using the diagnostic criteria for bv-FTD, and their caregivers retrospectively provided data to calculate the Autism-Spectrum Quotient, Japanese version [Wakabayashi et al.: Shinrigaku Kenkyu 2004;75:78–84]. We also compared these data with those obtained from 3 individuals with Alzheimer's disease. Results All 3 patients met the criteria for bv-FTD and had a higher Autism-Spectrum Quotient score than did comparable Alzheimer's disease subjects. Conclusion It is possible that some senile persons with frontotemporal lobar degeneration-like maladaptive behavior may suffer from subclinical AS. PMID:22719743
Walther, Christa G; Whitfield, Robert; James, David C
2016-04-01
The biopharmaceutical production process relies upon mammalian cell technology where single cells proliferate in suspension in a chemically defined synthetic environment. This environment lacks exogenous growth factors, usually contributing to proliferation of fibroblastic cell types such as Chinese hamster ovary (CHO) cells. Use of CHO cells for production hence requires a lengthy 'adaptation' process to select clones capable of proliferation as single cells in suspension. The underlying molecular changes permitting proliferation in suspension are not known. Comparison of the non-suspension-adapted clone CHO-AD and a suspension-adapted propriety cell line CHO-SA by flow cytometric analysis revealed a highly variable bi-modal expression pattern for cell-to-cell contact proteins in contrast to the expression pattern seen for integrins. Those have a uni-modal expression on suspension and adherent cells. Integrins showed a conformation distinguished by regularly distributed clusters forming a sphere on the cell membrane of suspension-adapted cells. Actin cytoskeleton analysis revealed reorganisation from the typical fibrillar morphology found in adherent cells to an enforced spherical subcortical actin sheath in suspension cells. The uni-modal expression and specific clustering of integrins could be confirmed for CHO-S, another suspension cell line. Cytochalasin D treatment resulted in breakdown of the actin sheath and the sphere-like integrin conformation demonstrating the link between integrins and actin in suspension-adapted CHO cells. The data demonstrates the importance of signalling changes, leading to an integrin rearrangement on the cell surface, and the necessity of the reinforcement of the actin cytoskeleton for proliferation in suspension conditions.
Baseline Profile of Participants in the Japan Environment and Children's Study (JECS).
Michikawa, Takehiro; Nitta, Hiroshi; Nakayama, Shoji F; Yamazaki, Shin; Isobe, Tomohiko; Tamura, Kenji; Suda, Eiko; Ono, Masaji; Yonemoto, Junzo; Iwai-Shimada, Miyuki; Kobayashi, Yayoi; Suzuki, Go; Kawamoto, Toshihiro
2018-02-05
The Japan Environment and Children's Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the environmental factors that might affect children's health and development. We report the baseline profiles of the participating mothers, fathers, and their children. Fifteen Regional Centres located throughout Japan were responsible for recruiting women in early pregnancy living in their respective recruitment areas. Self-administered questionnaires and medical records were used to obtain such information as demographic factors, lifestyle, socioeconomic status, environmental exposure, medical history, and delivery information. In the period up to delivery, we collected bio-specimens, including blood, urine, hair, and umbilical cord blood. Fathers were also recruited, when accessible, and asked to fill in a questionnaire and to provide blood samples. The total number of pregnancies resulting in delivery was 100,778, of which 51,402 (51.0%) involved program participation by male partners. Discounting pregnancies by the same woman, the study included 95,248 unique mothers and 49,189 unique fathers. The 100,778 pregnancies involved a total of 101,779 fetuses and resulted in 100,148 live births. The coverage of children in 2013 (the number of live births registered in JECS divided by the number of all live births within the study areas) was approximately 45%. Nevertheless, the data on the characteristics of the mothers and children we studied showed marked similarity to those obtained from Japan's 2013 Vital Statistics Survey. Between 2011 and 2014, we established one of the largest birth cohorts in the world.
Baseline Profile of Participants in the Japan Environment and Children’s Study (JECS)
Nitta, Hiroshi; Nakayama, Shoji F.; Yamazaki, Shin; Isobe, Tomohiko; Tamura, Kenji; Suda, Eiko; Ono, Masaji; Yonemoto, Junzo; Iwai-Shimada, Miyuki; Kobayashi, Yayoi; Suzuki, Go; Kawamoto, Toshihiro
2018-01-01
Background The Japan Environment and Children’s Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the environmental factors that might affect children’s health and development. We report the baseline profiles of the participating mothers, fathers, and their children. Methods Fifteen Regional Centres located throughout Japan were responsible for recruiting women in early pregnancy living in their respective recruitment areas. Self-administered questionnaires and medical records were used to obtain such information as demographic factors, lifestyle, socioeconomic status, environmental exposure, medical history, and delivery information. In the period up to delivery, we collected bio-specimens, including blood, urine, hair, and umbilical cord blood. Fathers were also recruited, when accessible, and asked to fill in a questionnaire and to provide blood samples. Results The total number of pregnancies resulting in delivery was 100,778, of which 51,402 (51.0%) involved program participation by male partners. Discounting pregnancies by the same woman, the study included 95,248 unique mothers and 49,189 unique fathers. The 100,778 pregnancies involved a total of 101,779 fetuses and resulted in 100,148 live births. The coverage of children in 2013 (the number of live births registered in JECS divided by the number of all live births within the study areas) was approximately 45%. Nevertheless, the data on the characteristics of the mothers and children we studied showed marked similarity to those obtained from Japan’s 2013 Vital Statistics Survey. Conclusions Between 2011 and 2014, we established one of the largest birth cohorts in the world. PMID:29093304
Araújo, Lia; Ribeiro, Oscar; Teixeira, Laetitia; Azevedo, Maria João; Jopp, Daniela S; Rott, Christoph; Paúl, Constança
2015-10-01
This study aims to present the psychometric properties of the Portuguese version of the Positive Valuation of Life Scale (Lawton et al. in J Aging Ment Healt 13:3-31, 2001). Sample included 207 community-dwelling elders (129 women; M Age = 77.2 years, SD = 7.5). The data collection included the translated and adapted Portuguese version of Positive Valuation of Life Scale, Life Satisfaction Index Z, Meaning in Life Questionnaire and Geriatric Depression Scale. From exploratory factor analysis, two factors emerged, existential beliefs and perceived control, explaining 49 % of the total variance. Both factors were positively related with meaning in life and life satisfaction and negatively related with depression (p < 0.05). The values obtained for internal consistency for the total scale and for each subscale were good (α > 0.75). The Portuguese version of Positive VOL Scale represents a reliable and valid measure to capture the subjective experience of attachment to one's life. The two-factor structure is an update to Lawton's previous work and in line with findings obtained in the USA (Dennis et al. in What is valuation of life for frail community-dwelling older adults: factor structure and criterion validity of the VOL, Thomas Jefferson University, Center for Applied Research on Aging and Health Research, 2005) and Japan (Nakagawa et al. in Shinrigaku Kenkyu 84:37-46, 2013). Future research is required to investigate VOL predictors and the potential changes toward the end of the life span.
Chen, Chia-Ching; Yamada, Tetsuji; Nakashima, Taeko; Chiu, I-Ming
2017-01-01
The purposes of this study are: (1) to empirically identify decision-making preferences of long-term health-care use, especially informal and formal home care (FHC) service use; (2) to evaluate outcomes vs. costs based on substitutability of informal and FHC service use; and (3) to investigate health outcome disparity based on substitutability. The methods of ordinary least squares, a logit model, and a bivariate probit model are used by controlling for socioeconomic, demographic, and physical/mental health factors to investigate outcomes and costs based substitutability of informal and formal health-care use. The data come from the 2013 Japanese Study of Aging and Retirement (JSTAR), which is designed by Keizai-Sangyo Kenkyu-jo, Hitotsubashi University, and the University of Tokyo. The JSTAR is a globally comparable data survey of the elderly. There exists a complement relationship between the informal home care (IHC) and community-based FHC services, and the elasticity's ranges from 0.18 to 0.22. These are reasonable results, which show that unobservable factors are positively related to IHC and community-based FHC, but negatively related to nursing home (NH) services based on our bivariate probit model. Regarding health-care outcome efficiency issue, the IHC is the best one among three types of elderly care: IHC, community-based FHC, and NH services. Health improvement/outcome of elderly with the IHC is heavier concentrated on IHC services than the elderly care services by community-based FHC and NH care services. Policy makers need to address a diversity of health outcomes and efficiency of services based on providing services to elderly through resource allocation to the different types of long-term care. A provision of partial or full compensation for elderly care at home is recommendable and a viable option to improve their quality of lives.
NASA Astrophysics Data System (ADS)
László, Márton, ,, Dr.
2010-05-01
Nowadays potato (Solanum tuberosum L.) is a more important throughout the world between field crops. As potato is such a potassium demanding crop, it is particularly important that the potassium fertilizers used should be correctly balanced. Applying the adequate quantity of balanced K- fertilizer is the first requirement for achieving optimum yield and doing so will result in potatoes of acceptable quality. Potato potassium nutrition has been studied at the Research Institute for Soil Science and Agricultural Chemistry of the Hungarian Academy of Sciences (RISSAC-HAS)- Experiment Station, Nagyhörcsök (chernozem soil) in a long term field experiment designed to determine NPK- nutrient requirements. The method of the experiment was 43 mixed factorial design with 64 treatments in 2 repetitions with 128 plots. The residual effects of K- levels brought about by build- up fertilization were studied. Potato were planted in 1978. The experimental dates were estimated by multivariate analysis of variance (MANOVA). On the basis of foliar analysis at early flowering about 4.5 to 5.0% K in dry matter proved to be satisfactory for obtaining maximum yield (32.6 t/ha). The yields increased by 22%, 34%, and 38% at 124-140, 141-168 and 169-208 ppm soil AL- K2O rates, respectively. The tubers concentrated much N 19% and less P 81% than potassium. Results for tuber maximum uptake of potassium reached a maximum about 130 days after planting. The improvement of the K supply of the soil increased yield and induced low concentrations of numerous microelements on leaves considered to be important. Key words: Potato (Solanum tuberosum L.), chernozem soil, potassium, yield Introduction Potato is an important food crop, more particularly in the temperate zone, especially in Europe and Asia. Between 1981 and 1995, in spite of an 18% decrease in cultivated area production increased by 13% because the average yield increased from 11.0 to 15.1 t/ha. Potato is a soil nutrients demanding crop and has a particularly high requirement for potassium. Tubers remove 1.5 times more potassium than nitrogen and 4 or 5 times the amount of phosphate. The quantity of nutrients taken up by a crop is not necessarily an indication of responsiveness to fertilizers but potato, because its root system is relativly poorly developed in relation to yield is extremly responsive to all nutrients (Márton 1984). As potato is such a demanding crop, it is particularly important that the potassium fertilizers used should be correctly balanced (Burton 1966). Applying the adequate quantity of balanced K- fertilizer is the first requirement for achieving optimum yield and doing so will result in potatoes of acceptable quality (Márton 2000). It is not the objective of present publication to give recommendations K- fertilizers which vary greatly according to local conditions. We intend to discuss various aspects of potassium effects on the basis of our research results. The importance of potatoes In terms of area planted, potato is the twelfth most important crop in all the world (18.48 million hectares) by FAO in 1995. In terms of total production it occupies the 5th position with 280 million t, between maize (515 mio) and sugar beet (266 mio). It is a high yielding crop. The world average being 15.1 t/ha, the third highest yielding crop on the bases of fresh matter following sugar cane (62.6 t/ha) and sugar beet (33.9 t/ha). Area planted, production and yield (1981 and 1995) Between 1981 and 1995 the total world area planted declined by 18%. While the importance of the crop declined more or less markedly in Europe, and in N. and C. America, there has been an increase in S. America (Márton 1999). The area planted in Asia has more than doubled and in Africa tripled. Despite of the reduction in area, world production has actually increased by 13% in the same period. This increase in production is due to a general 37% growth in yield from 11 to 15.1 t/ha. The potential yields of varieties, estimated at 85-100 t/ha for potato, 75-85 t/ha for beet and 12-15 t/ha for wheat (Evans 1977). These are far higher than the yields commonly obtained in practice. World average yields were only 1/6th of the potential for potato, 1/6th for wheat and 2/5th for sugar beet in 1995. Utilization of the crop The major part of potato production is usually used for human consumption. Human consumption of potatoes however has declined in the industrialised countries as the standard of living has increased. In these countries an increasing proportion of the crop is used for manufacturing products such as crisp, oven-ready chips, dehydrated potato powder. Thus, in Hungary the consumption of potatoes per person decreased from 110 kg in 1951/1960 to 60 kg in 1995, whereas the consumption of processed potatoes increased from 1 to 15 kg/person during this period. Uptake of potassium Potassium is the nutrient taken up by potato in the greatest quantity, it also takes up much nitrogen and appreciable amounts of phosphorus, calcium, magnesium and sulphur (Perrenoud 1993). Maximum uptakes by different varieties in Japan range between 140 and 267 K2O (Kali Kenkyu Kai 1980). In England, potatoes grown on the " blueprint" system and giving the very high yield of 77.7 t/ha took up 450 kg/ha K2O (Anderson and Hewgill 1978). Brazílian experiments with 6 varieties showed the following uptakes (kg/ha): potassium 207-367 (Motta 1976). Removal of potassium by tubers 23 experimental crops in France (Loué 1977), -with a mean yield of 37.3 t/ha tubers removed: 196 kg K2O, respectively. It is equal to 5.3 kg K2O per 1 tonne tuber. Motta Macedo (1976) reports the following removals in kg/ha for 6 varieties grown in Brazíl: K2O: 118-192. In 14 experiments in India (Grewal and Singh 1979) a mean yield of 28.8 t/ha tuber was obtained which removed an average of 91 kg/ha K2O. At very high yield level, nutrient removal in tuber is very high. Anderson and Hewgill (1978) report a yield of 90 t/ha, obtained at Stockbridge House in 1973 which contained 487 kg K2O in the tubers. The effects of potassium fertilizer on yield The averages of 1267 experimental results (607 from 8 developed countries and 660 from 10 developing countries) were estimated. Yields increased by 14, 10 and 11% for 1-100, 101-200 and 201-300 kg/ha K2O rates, respectively. The greater average effect of potassium on yield at the 1-100 kg/ha K2O rate as compared to higher doses was due to the strong effect of this nutrient in experiments. 1 kg K2O produces 32, 16 and 13 kg tubers when 1-100, 101-200 and 201-300 kg/ha K2O are applied. An example of the effect of potassium on yield is in the Siebold (1971) reports that heavy potash dressing had spectacular effects on yield on a soil which fixed potassium strongly. Nutrient interactions In 17 years of a long- term experiment at Aspach (France) (Loué 1977) positive interactions between N and K were recorded in 15 years and negative in 2. Yadav and Tripathi (1973) recorded an NxK interaction amounting to 4.44 t/ha tubers in India. Materials and Methods The NPK fertilization field trial was set up at the Nagyhörcsök Experiment Station of the Research Institute for Soil Science and Agricultural Chemistry of the Hungarian Academy of Sciences by Imre Kádár in the autumn of 1973. The method of the experiment was 43 design of the mixed factorial with 64 treatments, in 2 repetitions with 128 plots. The gross and net size of the plots were 6 x 6 = 36 m2 and 24.5 m2 respectivly. N fertilization was repeated yearly. As regards P and K residual effects of nutrient levels brought about by build-up fertilization in autumn 1973, were recorded. The experiment was carried out in South-East Hungary on a calcareous chernozem soil. The clay fraction (0.002 mm) content of the soil was 20 % and silt fraction (0.02 mm) 40 %. The 0.05-0.02 mm fraction was 35-50 %. The main characteristics of the soil (plough layer) are as follows: CaCO3 5 %, humus 3 %, pH(KCl) = 7.4-7.8, AL-P2O5 = 50-80 ppm, AL-K2O = 120-140 ppm, Mg(KCl) = 120-150 ppm, EDTA-Mn = 100-150 ppm, EDTA-Zn = 1-2 ppm, EDTA-Cu = 2-4 ppm. The initial nutrient supply of the soil was poor in P and medium in K. After build-up fertilization (1973) the easily soluble phosphorus and potassium contents of the soil rapidly decreased without yearly maintenance fertilization. In the first four years of the experiment winter wheat-winter wheat-maize-maize were grown. Potatoes (variety: Desirée) were planted by hand in 1978. Plant sampling was carried out by averaging 20 subsamples per plot. The experimental data were estimated by multivariate analysis of variance, MANOVA. In this paper We would like to present the potassium effects on potato yield. Results and Discussion Uptake of potassium Under the experimental conditions of 1978, on the basis of foliar analysis at early flowering, in dry matter about 4.5 to 5.0% K proved to be satisfactory for obtaining maximum yield (32.6 t/ha). Effects of K- fertilizers on yield Potato yields increased by 22%, 34% and 38% at 124-140, 141-168 and 169-208 ppm soil AL- K2O rates, respectively. That the average effect of potassium on yield was greater at 208 ppm K2O than at higher rates is due to the strong effect of this nutrient in experiments. 1 ppm K2O produced 268, 232 and 185 kg tubers when 124-140, 141-168 and 169-208 ppm K2O were applied. These results are very similar to those reported by Siebold (1971), he found that heavy dressing of potash had spectacular effects on the yield on a soil with strong potassium- fixing ability. Removal of potassium and other nutrients in tuber The tubers removed much nitrogen, 0.1 times more than potassium and 6 times as much as phosphorus. Removal of calcium and magnesium were much lower but still significant. In experiment- giving a mean yield of 32.6 t/ha tubers on K- effects on average of NP removed 454 kg N, 76 kg P2O5, 488 kg K2O, 81 kg CaO, 26 kg MgO and 14 kg/t N, 2 kg/t P2O5, 15 kg/t K2O, 3 kg/t CaO and 0.8 kg per tonne MgO, respectivly. We found that 32.6 t/ha crop removed 1.8 kg sodium, 1.6 kg iron, 400 g zinc and 100 g manganese. Pattern of potassium and other nutrient uptake The uptake of nutrients during potato growth were studied. Results for tuber average uptake of nitrogen (472 kg/ha), phosphorus (77 kg/ha) and potassium (426 kg/ha) reached a maximum about 130 days after planting. It was observed that crop took up about 3.6 kg N, 0.5 kg P and 3.0 kg K per ha per day. Nutrient interaction Improving K- supply of the soil was found to increase yield and induce low concentration of numerous elements on leaves considered as important. K- fertilization had a negative effect mainly on the Mg and Ca contents. Thus e.g. K/Mg ratio increased from 3 to 11 at yearly flowering as an effect of K fertilization, that however, should not be considered an unfavourable ratio as yet and on these plots K fertilization still remained effective. Acknowledgements This research was supported by Research Institute for Soil Science and Agricultural Chemistry of the Hungarian Academy of Sciences. References Anderson, G.D.-Hewgill, D. (1978).: Effects of nitrogen, phosphorus and potassium on ‘Blueprint' grown potatoes. Maximising Yields of crops. ADASARC Symposium. 139-150. Burton, W.G. (1966).: The potato. Veemann. Wageningen. Evans, S.A. (1977).: The place of fertilizers in ‘Blueprints' for the production of potatoes and cereals. Fertilizer use and production of carbohydrates and lipids. Proc. 13th Coll. Inst. Bern, 231-241. FAO. (1995).: Production Yearbook, Vol. 49. Grewal, J.S. (1975).: Manuring of potatoes. Indian Farming. 25:15-17. Kali, K.K. (1980).: Private communication. Tokyo. Loué, A. (1977).: Fertilisation et nutrition minérale de la pomme de terre. Expérimentation et études agronomiques, SCPA. Mulhouse. 147. Márton, L. (1984).: Fertilization effects on potato yield and quality. Doctoral dissertation. KAU. Keszthely. Márton, L.-Jose, A.B. (1999).: Potato (Solanum tuberosum L.) production in Brazíl. Acta Agronomica Óváriensis. 41:153-158. Márton, L. (2000).: Nitrogen, phosphorus and potassium effects on potato quality. In: Agro markets and conditions. Agricultural University of Veszprém. 241-247. Keszthely. Hungary. Motta Macedo, M.C. (1976).: Absorcao de nutrientes por cultivares nacionais de batatinha (Solanum tuberosum L.). Diss., Escola Superior. Luiz de Queiroz da Universidade de Sáo Paulo. Perrenoud, S.: (1993).: Potato. Fertilizing for high yield. IPI Bulletin. N.8. Basel. Switz. Siebold, M. (1971).: Kartoffelanbau auf kalifixierenden Böden. Kartoffelbau. 22:12-13. Yadav, S.C.-Tripathi, B.R. (1973).: Studies on soil moisture regimes and nitrogen, phosphorus and potash fertilization on yield of potato (S. tuberosum L.). Plant Sci. 5:97-104.