Sample records for key bridge marriott

  1. 77 FR 3478 - Center for Scientific Review; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Marriott Tysons Corner, 1960--A Chain Bridge Road, McLean, VA 22102. Contact Person: Martha M Faraday, Ph.D... Marriott Tysons Corner, 1960-A Chain Bridge Road McLean, VA 22102. Contact Person: Martha M Faraday, Ph.D...

  2. The Marriott Secret: Put Your Staff First. The Endpaper.

    ERIC Educational Resources Information Center

    Marriott, J. W., Jr.

    1983-01-01

    The key to the success of the Marriott Corporation is its emphasis on employee satisfaction and training. Because it is a service industry, the Marriott Corporation relies on the quality of the contact between its employees and its customers. Education is also a service industry in which this contact is vitally important. Some ingredients of…

  3. Urban Youth with Disabilities: Factors Affecting Transition Employment

    ERIC Educational Resources Information Center

    Fabian, Ellen S.

    2007-01-01

    Although postsecondary employment outcomes for transition-age youth with disabilities have improved over the past decade, minority youth with disabilities continue to lag behind their peers in achieving a job. This study of predominantly minority youth participating in the Marriott Foundation's Bridges From School to Work Program from 2000 to 2005…

  4. 75 FR 61705 - Fisheries of the South Atlantic and Gulf of Mexico; Southeast Data, Assessment, and Review (SEDAR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... and times. ADDRESSES: The Review Workshop will be held at the Key West Marriott Beachside Hotel, 3841 N. Roosevelt Blvd, Key West, FL 33040; telephone: (305) 296-8100. FOR FURTHER INFORMATION CONTACT...

  5. Of Tipping Points and Sinking Ships: A Conversation between James Marriott and Suzi Gablik

    ERIC Educational Resources Information Center

    Gablik, Suzi; Marriott, James

    2007-01-01

    This article presents a conversation between the authors, James Marriott and Suzi Gablik. Marriott is a founding member and co-director of PLATFORM, a London-based, award-winning organization focused on social and ecological justice. Gablik is the author of "The Reenchantment of Art," "Conversations Before the End of Time," and "Living the Magical…

  6. 77 FR 12863 - Towing Safety Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... later than March 15, 2012. ADDRESSES: The meetings will be held at the Houston Marriott South at Hobby...-houston-hobby-airport-marriott/ . To facilitate public participation, we are inviting public comment on...

  7. 77 FR 47864 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ...), Interior. ACTION: Notice of meeting. SUMMARY: OESC will meet at the Anchorage Marriott Downtown Hotel in..., from 8 a.m. to 1 p.m. ADDRESSES: Anchorage Marriott Downtown Hotel, 820 West 7th Avenue, Anchorage...

  8. 76 FR 15988 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... assistance, such as sign language interpretation or other reasonable accommodations, should notify the... plan. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level... proposals. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level...

  9. 75 FR 76019 - National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... strategic plan. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level... proposals. Place: Bethesda Marriott Suites, 6711 Democracy Boulevard, Independence Room (2nd Level), Bethesda, MD 20817. Contact Person: Anthony Demsey, PhD, Director, National Institute of Biomedical Imaging...

  10. 75 FR 27563 - Federal Radiological Preparedness Coordinating Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... 21, 2010. ADDRESSES: The meeting will be held at the Crystal City Courtyard Marriott, Blue Ridge... holding a public meeting on June 3, 2010, from 9 a.m. to 11 a.m., at the Crystal City Courtyard Marriott.... Reasonable provisions will be made, if time permits, for oral statements from the public of not more than...

  11. 76 FR 38428 - Maritime Advisory Committee for Occupational Safety and Health (MACOSH)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... Real, San Diego, CA 92130. http://www.marriott.com/hotels/travel/sandm-san-diego-marriott-del-mar... attend the full MACOSH committee and its workgroup meetings at the time and place listed above. The... section above. The request must state the amount of time requested to speak, the interest represented (e.g...

  12. 76 FR 72369 - Safety Zone; Marco Island Marriott Charity Fireworks Display, Gulf of Mexico, Marco Island, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ...-AA00 Safety Zone; Marco Island Marriott Charity Fireworks Display, Gulf of Mexico, Marco Island, FL... establish a temporary safety zone on the waters of the Gulf of Mexico in the vicinity of Marco Island... reached the Facility, please enclose a stamped, self-addressed postcard or envelope. We will consider all...

  13. Library Survival. Workbook in Library Skills: A Self-Directed Course in the Use of the Marriott Library. General Studies 101.

    ERIC Educational Resources Information Center

    Gittins, Gwen; Dusenbury, Carolyn

    Designed to acquaint undergraduate students at the University of Utah with basic library resources and materials, the program of instruction presented can be used as a self-paced tool either in course related instruction or as an independent offering. A section containing floor plans of the University's Marriott Library illustrates the location of…

  14. Microencapsulation of Ascorbic Acid for Enhanced Long-term Retention during Storage

    DTIC Science & Technology

    2011-01-01

    in fortified instant Asian noodles by use of capillary electrophoresis. Food Chemistry 112(2): 507–514. Hau Fung Cheung, R., Marriott, P.J . and...D., Small, D. M. and Marriott, P. J. (2008). Investigation of folic acid stability in fortified instant noodles by use of capillary electrophoresis...processing and preparation of instant Asian noodles . PhD thesis, RMIT University: Melbourne. Head, M.K. and Hansen, A.P. (1979). Stability of L

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    The fiscal year (FY) 2013 U.S. Department of Energy (DOE) Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting (AMR), in conjunction with DOE's Vehicle Technologies Office AMR, was held from May 13-16, 2013, at the Crystal City Marriott and Crystal Gateway Marriott in Arlington, Virginia. This report is a summary of comments by AMR peer reviewers about the hydrogen and fuel cell projects funded by DOE's Office of Energy Efficiency and Renewable Energy (EERE).

  16. Recommendations for Future Army Analysis Efforts. Volume 4. Key Questions and Recommendations for Future Analysis Efforts on Explaining the Army and Supporting the Soldier

    DTIC Science & Technology

    1988-04-14

    McDonalds or Burger King for snack shops, Marriott for messing/billeting facilities, etc.? RECOMMENDED ELEMENTS OF ANALYSIS/TOPICAL AREAS: DATE RESULTS ITEM...e.g., a Burger King on post) now brings in about SI million per month to the family support coffers. It began in 1984 and has returned $21 million...Army, private sector franchises and family support. - The first or leading question is whether the family affects retention and, if so, what the Army

  17. James Henry Marriott: New Zealand's first professional telescope-maker

    NASA Astrophysics Data System (ADS)

    Orchiston, Wayne; Romick, Carl; Brown, Pendreigh.

    2015-11-01

    James Henry Marriott was born in London in 1799 and trained as an optician and scientific instrument- maker. In 1842 he emigrated to New Zealand and in January 1843 settled in the newly-established town of Wellington. He was New Zealand's first professional telescope-maker, but we have only been able to locate one telescope made by him while in New Zealand, a brass 1-draw marine telescope with a 44-mm objective, which was manufactured in 1844. In 2004 this marine telescope was purchased in Hawaii by the second author of this paper. In this paper we provide biographical information about Marriott, describe his 1844 marine telescope and speculate on its provenance. We conclude that although he may have been New Zealand's first professional telescope-maker Marriot actually made very few telescopes or other scientific instruments. As such, rather than being recognised as a pioneer of telescope-making in New Zealand he should be remembered as the founder of New Zealand theatre.

  18. The value-adding CFO: an interview with Disney's Gary Wilson. Interview by Geraldine E. Willigan.

    PubMed

    Wilson, G

    1990-01-01

    Financing a company is more complex than ever-and more important to its economic success. The demands on a CFO are tremendous. Optimizing capital costs requires an unprecedented level of technical sophistication. Yet the best CFOs today are not mere technicians. They are also strategists and innovators. Gary Wilson exemplifies the new CFO. In his 5 years as executive vice president and CFO of the Walt Disney Company and his 12 years at Marriott Corporation, he has shown how the finance function can add value-not just account for it. How does a CFO create value for shareholders? "Just like all the great marketing and operating executives," Wilson says, "by being creative." To Wilson, being creative means rethinking assumptions and finding clever ways to achieve financial and strategic goals. Some of Wilson's innovative deal making-like the off-balance-sheet financing he used at Marriott-is well known. At Marriott, he discovered the power of separating the ownership of an asset from its control. Marriott's strength was in operations, yet the company had a great deal of money tied up in real estate. Growth would require even more investment in real estate. Wilson's solution was to sell the hotels-in effect, removing them and the debt used to finance them from the balance sheet-and contract to operate them. In this interview, Wilson gives his view of the role of finance in today's corporation and explains the thinking behind some of the successful deals he has engineered-including Disney's Silver Screen movie-making partnerships and Euro Disneyland.

  19. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Administrator Charles Bolden gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  20. 77 FR 63849 - National Offshore Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... public comments. ADDRESSES: The meetings will be held at the Marriott South Hobby Airport Hotel, 9100... South Hobby Airport Hotel, in the Corpus Christi/South Padre Rooms. For information on facilities or...

  1. 75 FR 21005 - National Advisory Council on the National Health Service Corps; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... (BCRS), discuss recruitment and marketing strategies for the NHSC, and address current workforce issues.... Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852, Phone...

  2. 75 FR 8374 - National Human Genome Research Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Emphasis Panel, Revolutionary Sequencing Technology. Date: April 2, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Crystal City Marriott at Regan National Airport, 1999...

  3. 76 FR 22112 - National Human Genome Research Institute; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Emphasis Panel, Special Emphasis Panel (SEP)--Model Organism database (MOD). Date: June 20, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Crystal Gateway Marriott...

  4. 78 FR 64967 - Center for Scientific Review; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ....m., Crystal City Marriott, 1999 Jefferson Davis Highway, Arlington, VA 22202 which was published in... and end on November 15, 2013. The time and location remain the same. The meeting is closed to the...

  5. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Marion C. Blakey, President and CEO, Aerospace Industries Association, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  6. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Leland Melvin, right, Education Design Team Co-Chair and NASA Astronaut, speaks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  7. Early Restoration Public Meeting, Alabama | NOAA Gulf Spill Restoration

    Science.gov Websites

    Public Meeting, Alabama Date: January 23, 2012 Location: Mobile, Alabama Description: The Deepwater public meeting starting at 7:00 p.m. Address: Battle House Marriott Hotel 26 North Royal Street Mobile

  8. A "Capital" Venture.

    ERIC Educational Resources Information Center

    Brotherton, Phaedra

    2000-01-01

    Describes the program at Marriott Hospitality Public Charter High School in Washington, DC, the nation's only high school devoted to the hospitality industry. A career academy, the school provides mentoring and real-world work experiences in collaboration with industry professional associations. (JOW)

  9. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    James Stofan, right, NASA Acting Associate Administrator for Education, introduces the keynote speakers at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  10. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Cora B. Marrett, right, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  11. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Cora B. Marrett, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  12. 77 FR 56215 - National Cancer Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road... & Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd... Review & Logistics Branch, Division of Extramural Activities, 6116 Executive Boulevard, Room 8146...

  13. 76 FR 55837 - Workshops To Discuss Revisions to Federal and Indian Coal Valuation Regulations: Advance Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ...-3585. Workshop 2--Marriott St. Louis Airport, 10700 Pear Tree Lane, St. Louis, Missouri 63134..., each person may be required to present a picture identification to gain entry to the meetings. Dated...

  14. 75 FR 8063 - Stakeholder Meeting Regarding Revisions to the Unregulated Contaminant Monitoring Regulation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... meeting will be held at the Crystal City Marriott at Reagan National Airport, in the Salon D Room, at 1999 Jefferson Davis Highway, Arlington, VA 22202. The hotel is located near the Ronald Reagan Washington...

  15. Effect of mechanical degradation of laminated elastomeric bearings and shear keys upon seismic behaviors of small-to-medium-span highway bridges in transverse direction

    NASA Astrophysics Data System (ADS)

    Wu, Gang; Wang, Kehai; Zhang, Panpan; Lu, Guanya

    2018-01-01

    Laminated elastomeric bearings have been widely used for small-to-medium-span highway bridges in China, in which concrete shear keys are set transversely to prohibit large girder displacement. To evaluate bridge seismic responses more accurately, proper analytical models of bearings and shear keys should be developed. Based on a series of cyclic loading experiments and analyses, rational analytical models of laminated elastomeric bearings and shear keys, which can consider mechanical degradation, were developed. The effect of the mechanical degradation was investigated by examining the seismic response of a small-to-medium-span bridge in the transverse direction under a wide range of peak ground accelerations (PGA). The damage mechanism for small-to-medium-span highway bridges was determined, which can explain the seismic damage investigation during earthquakes in recent years. The experimental results show that the mechanical properties of laminated elastomeric bearings will degrade due to friction sliding, but the degree of decrease is dependent upon the influencing parameters. It can be concluded that the mechanical degradation of laminated elastomeric bearings and shear keys play an important role in the seismic response of bridges. The degradation of mechanical properties of laminated elastomeric bearings and shear keys should be included to evaluate more precise bridge seismic performance.

  16. 77 FR 2734 - National Advisory Council on Migrant Health; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... Advisory Council on Migrant Health. Dates and Times: February 7, 2012, 8:30 a.m. to 5 p.m.; February 8, 2012, 8:30 a.m. to 5 p.m. Place: Crystal Gateway Marriott Hotel, 1700 Jefferson Davis Highway...

  17. 78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... Person: Donald L Coppock, Ph.D., Scientific Review Officer, Special Review and Logistics Branch, Division... Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Ellen K Schwartz, EDD, Scientific Review Officer, Special Review and Logistics Branch, Division of Extramural...

  18. 76 FR 11773 - Environmental Management Site-Specific Advisory Board, Northern New Mexico

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Northern New Mexico... the Environmental Management Site-Specific Advisory Board (EM SSAB), Northern New Mexico. The Federal... Courtyard by Marriott, 3347 Cerrillos Road, Santa Fe, New Mexico 87507. FOR FURTHER INFORMATION CONTACT...

  19. 2009 TOXICOLOGY AND RISK ASSESSMENT CONFERENCE

    EPA Science Inventory

    EPA has announced

    The 2009 Toxicology and Risk Assessment Conference
    Cincinnati Marriott North, West Chester (Cincinnati), OH
    April 27-30, 2009 - Click to register!

    The Annual Toxicology and Risk Ass...

  20. 2008 TOXICOLOGY AND RISK ASSESSMENT CONFERENCE

    EPA Science Inventory

    EPA has announced

    The 2008 Toxicology and Risk Assessment Conference
    Cincinnati Marriott North, West Chester (Cincinnati), OH
    April 14 - 17, 2008 - Click to register!

    The Annual Toxicology and Risk ...

  1. 2007 TOXICOLOGY AND RISK ASSESSMENT CONFERENCE

    EPA Science Inventory

    EPA has announced

    The 2007 Toxicology and Risk Assessment Conference
    Cincinnati Marriott North, West Chester (Cincinnati), OH
    April 23- 26, 2007 - Click to register!

    The Annual Toxicology and Risk Ass...

  2. 76 FR 3639 - National Advisory Council on the National Health Service Corps; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... Partnerships, Clinician Retention and NHSC Communications and Marketing Strategies will also be part of the...: February 10, 2011--1 p.m.-4 p.m.; February 11, 2011--8:30 a.m.- 4 p.m. Place: Bethesda North Marriott Hotel...

  3. 75 FR 11870 - Inland Waterways Users Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ...: April 13, 2010. Location: The Waterford at Springfield, Gibson Ballroom, 6715 Commerce Street, Springfield, VA 22150, (703) 719-5700, accommodations at Courtyard by Marriott Springfield, 6710 Commerce... will begin at 1 p.m. and the meeting is scheduled to adjourn at approximately 5 p.m. Agenda: The Board...

  4. From Charity School to Workhouse in the 1720's: The SPCK and Mr Marriott's Solution.

    ERIC Educational Resources Information Center

    Simon, Joan

    1988-01-01

    Traces the progress of the Society for Promoting Christian Knowledge's (England) charity school movement in the early eighteenth century and its shift from promotion of catechistical instruction to putting children to work in workhouses that served to banish idleness and beggary. (GEA)

  5. 75 FR 57537 - Sunshine Act; Notice of Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ..., 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). * * * * * * The schedule for Commission..., 2010 1 p.m. Briefing on Resolution of Generic Safety Issue (GSI)--191, Assessment of Debris... 18, 2010 1:30 p.m. NRC All Employees Meeting (Public Meeting) Marriott Bethesda North Hotel, 5701...

  6. 75 FR 61227 - Sunshine Act: Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... on Security Issues (Closed--Ex. 1). Week of November 1, 2010--Tentative Tuesday, November 2, 2010 9..., 2010 1:30 p.m.--NRC All Employees Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m.--Briefing on Medical Issues (Public...

  7. 77 FR 65728 - Notice of Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ....nrc.gov. Thursday, November 29, 2012 2:30 p.m. Briefing on Security issues (Closed Ex-1) Week of... Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2). Week of November 12...

  8. 78 FR 801 - National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2012... Committee Meeting AGENCY: National Highway Traffic Safety Administration (NHTSA), U.S. Department of...: The meeting will be held in the Delaware Room of the Marriott Wardman Park at 2660 Woodley Road NW...

  9. 76 FR 58767 - Board for International Food and Agricultural Development; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... International Food and Agricultural Development; Notice of Meeting Pursuant to the Federal Advisory Committee Act, notice is hereby given of the public meeting of the Board for International Food and Agricultural... Moines Marriott located at 700 Grand Avenue, Des Moines, Iowa. ``The Next Generation: Global Food...

  10. 77 FR 66623 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... and Health Disparities Special Emphasis Panel; NIMHD Community-Based Participatory Research (CBPR... Marriott Suites, 6711 Democracy Boulevard, Bethesda, MD 20817. Contact Person: Robert Nettey, M.D., Chief... of Health, 6707 Democracy Blvd., Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

  11. 50th JANNAF Propulsion Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Eggleston, Debra S. (Editor)

    2001-01-01

    This volume, the first of two volumes, is a collection of 29 unclassified/unlimited-distribution papers which were presented at the 50th Joint Army-Navy-NASA-Air Force (JANNAF) Propulsion Meeting, held 11-13 July 2001 at the Salt Lake City Marriott Hotel in Salt Lake City, Utah.

  12. National Workplace Literacy Program 1994-1997. Final Grant Report.

    ERIC Educational Resources Information Center

    Faulkner, Cynthia

    This report provides information on a workplace education program in which Emily Griffith Opportunity School, Denver, partnered with Columbia HealthONE, Dobbs International Services, Imperial Headwear, Inc., Marriott Hotels, Provenant Health Partners, University of Colorado Health Science Center, and Westin Hotel. Section A of Part I, a program…

  13. 76 FR 25666 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... COMMISSION ON CIVIL RIGHTS Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of meeting. DATE AND TIME: Friday, May 13, 2011; 9 a.m. EDT. PLACE: The Washington Marriott at Metro Center, Junior Ballroom Salons 1 and 2, 775 12th Street, NW., Washington, DC 20005...

  14. Key Royale bridge five year evaluation.

    DOT National Transportation Integrated Search

    2013-06-01

    This report describes the design, construction, instrumentation, and five-year evaluation of the Key Royale Bridge substructure. The primary focus was the evaluation of the implementation of highly reactive supplementary cementitious materials (SCM) ...

  15. 76 FR 26720 - 2011 Annual Meeting of the Ozone Transport Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... efficiency, architectural industrial and maintenance coatings, consumer products, institution commercial and..., aftermarket catalysts, lightering, and non- road idling. DATES: The meeting will be held on June 15, 2011 starting at 9 a.m. and ending at 3:30 p.m. Location: Washington Marriott Wardman Park, 2660 Woodley Road NW...

  16. 76 FR 35225 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections.... Place: Courtyard by Marriott, 5520 Wisconsin Avenue, Chevy Chase, MD 20815. Contact Person: Charles N...-5019, charles[email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.846...

  17. 77 FR 32651 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections...). Contact Person: Charles H Washabaugh, Ph.D., Scientific Review Officer, Scientific Review Branch, National... applications. Place: Bethesda Marriott, 5151 Pooks Hill Road, Bethesda, MD 20814. Contact Person: Charles N...

  18. 77 FR 13133 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, March 22, 2012, 8 a.m. to March 23, 2012, 5 p.m., Bethesda North Marriott...

  19. 76 FR 37358 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, July 7, 2011, 8 a.m. to July 8, 2011, 5 p.m., Bethesda North Marriott...

  20. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    William Kelly, PhD, PE, Manager, Public Affairs, American Society for Engineering Education speaks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Seated are NASA Administrator Charles Bolden, left, and NASA Acting Associate Administrator for Education, James Stofan. (Photo Credit: NASA/Carla Cioffi)

  1. 75 FR 7615 - Towing Safety Advisory Committee; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... will meet in New Orleans, LA. The Committee will also discuss various issues relating to shallow-draft... March 2, 2010. ADDRESSES: The meetings will be held at the New Orleans Marriott Metairie at Lakeway in New Orleans, LA; 3838 N. Causeway Boulevard, Metairie, LA 70002; Phone: 1-504-836-5253, Toll-free: 1...

  2. Can Models Capture the Complexity of the Systems Engineering Process?

    NASA Astrophysics Data System (ADS)

    Boppana, Krishna; Chow, Sam; de Weck, Olivier L.; Lafon, Christian; Lekkakos, Spyridon D.; Lyneis, James; Rinaldi, Matthew; Wang, Zhiyong; Wheeler, Paul; Zborovskiy, Marat; Wojcik, Leonard A.

    Many large-scale, complex systems engineering (SE) programs have been problematic; a few examples are listed below (Bar-Yam, 2003 and Cullen, 2004), and many others have been late, well over budget, or have failed: Hilton/Marriott/American Airlines system for hotel reservations and flights; 1988-1992; 125 million; "scrapped"

  3. New Approaches for Early Detection of Breast Tumor Invasion or Progression

    DTIC Science & Technology

    2003-05-01

    IMMUNOHISTOCHEMICAL ASSESSMENT OF \\ Breast Disease PRIMARY LESIONS OF BREAST EPITHELIAL February 13-16, 2003 INVASION INTO BLOOD VESSELS Ritz - Carlton , Amelia...Programs, The Idea Award (BCOOI 187) and Career Development m ~ ~ ~ ~ ~ wr g .••• m Vol 16,’ No MEETING March 22 - 28, 2003 Marriott Wardman Park Hotel

  4. 76 FR 81480 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... specific times. ADDRESSES: The meeting will be held at the Harbor Beach Marriott, 3030 Holiday Drive, Ft... Information Officer, South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201, N... is physically accessible to people with disabilities. Requests for auxiliary aids should be directed...

  5. Key Royale bridge five year evaluation : [summary].

    DOT National Transportation Integrated Search

    2013-06-01

    The Florida Department of Transportation (FDOT) : maintains more than 6,500 bridges. Considering : the expense of repair and replacement of bridges, : extending their durability and service life is : important. Of special concern for bridges in : mar...

  6. 18. Interior view, 'Inside Key Route Inspection Bldg.', view to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Interior view, 'Inside Key Route Inspection Bldg.', view to east, August 16, 1939. Note inspection pits and work areas beneath tracks. The Key Route and Interurban Electric Railway Bridge Yard Shop buildings were identical, and this view provides an in-service look at the well-lit interior. While Key Route articulated cars were quite different in design from the Interurban Electric Railway cars, the maintenance requirements were quite similar. The Key Route Bridge Yard Shop building was demolished in the 1970s. Its last use was storage of much of the historic railway equipment now on display at the California State Railroad Museum in Sacramento. - Interurban Electric Railway Bridge Yard Shop, Interstate 80 at Alameda County Postmile 2.0, Oakland, Alameda County, CA

  7. Faster bridge construction using precast substructures : brief.

    DOT National Transportation Integrated Search

    2011-07-01

    Bridge replacement often requires road closures and detours that frustrate road users. It remains a key goal of Wisconsin DOT to reduce construction-related road use interruptions. This will be a challenge with bridges: Bridge inspections in 2007 ide...

  8. The key quality control technology of main cable erection in long-span suspension bridge construction

    NASA Astrophysics Data System (ADS)

    Chen, Yongrui; Wei, Wei; Dai, Jie

    2017-04-01

    Main cable is one of the most important structure of suspension Bridges, which bear all the dead and live load from upper structure. Cable erection is one of the most critical process in suspension bridge construction. Key points about strand erection are studied in this paper, including strand traction, lateral movement, section adjustment, placing into saddle, anchoring, line shape adjustment and keeping, and tension control. The technology has helped a long-span suspension bridge in Yunnan Province, China get a ideal finished state.

  9. Lodging in Boulder and Louisville, Colorado | NREL

    Science.gov Websites

    Leadership Community Education Center Economic Impact Environment, Health, & Safety Sustainability Energy : 720-587-3014 Comfort Inn 1196 W. Dillon Road Louisville, CO 80027 Phone: 303-604-0181 Courtyard by Marriott 948 West Dillon Road Louisville, CO 303-604-0007 Hampton Inn 912 W. Dillon Road Louisville, CO

  10. 78 FR 66018 - Center for Scientific Review; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Innate Immunity and Inflammation Study Section, October 03, 2013, 08:00 a.m. to October 04, 2013, 05:00 p.m., Marriott Residence...

  11. 78 FR 64519 - Center for Scientific Review; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Cancer Biomarkers Study Section, October 18, 2013, 08:00 a.m. to October 18, 2013, 06:00 p.m., Houston JW Marriott, 5150...

  12. International Students in a U.S. Graduate Business Program: Cultures, Subcultures, and the New Student.

    ERIC Educational Resources Information Center

    Howard, Janet M.; Keele, Reba

    This paper discusses the development, implementation, and results of an intercultural training program for the students of the Marriott School of Management (MSM) at Brigham Young University, Utah. Complaints from MSM international students that they felt some sense of abandonment by MSM and the university promoted a research study on…

  13. 77 FR 76058 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    .... Time: 2:00 p.m. to 3:00 p.m. Agenda: To review and evaluate contract proposals. Place: Crystal City.... Date: January 15, 2013. Time: 8:30 a.m. to 11:30 a.m. Agenda: To review and evaluate contract proposals. Place: Crystal City Marriott, 1999, Jefferson Davis Highway, Arlington, VA 22202. Contact Person...

  14. 76 FR 37788 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... meeting of its Law Enforcement AP in Orlando, FL. DATES: The meeting will take place July 20, 2011. See SUPPLEMENTARY INFORMATION. ADDRESSES: The meeting will be held at the Marriott Renaissance Orlando Hotel, 5445 Forbes Place, Orlando, FL 32812; telephone: (407) 240-1000. FOR FURTHER INFORMATION CONTACT: Kim Iverson...

  15. 78 FR 64228 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 16, 2013, 04:00 p.m. to October 17, 2013, 05:00 p.m., Bethesda North Marriott Hotel & Conference Center, 5701...

  16. 78 FR 66024 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 16, 2013, 08:00 a.m. to October 17, 2013, 05:00 p.m., Bethesda North Marriott, Rockville, MD which was...

  17. 78 FR 64228 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 17, 2013, 05:00 p.m. to October 18, 2013, 06:00 p.m., Bethesda North Marriott Hotel & Conference Center, 5701...

  18. 78 FR 64223 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, November 07, 2013, 8:00 a.m. to November 07, 2013, 6:00 p.m., Bethesda North Marriott Hotel & Conference Center, 5701...

  19. 78 FR 58323 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 17, 2013, 4:00 p.m. to October 18, 2013, 06:00 p.m., Bethesda North Marriott Hotel & Conference Center, 5701...

  20. 78 FR 64958 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 15, 2013, 4:00 p.m. to October 16, 2013, 5:00 p.m., Bethesda North Marriott Hotel & Conference Center, 5701...

  1. 77 FR 22787 - HIT Policy Committee Advisory Meeting; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... consistent with the Federal Health IT Strategic Plan and that includes recommendations on the areas in which... will be held on May 2, 2012, from 9:30 a.m. to 3 p.m./Eastern Time. Location: Washington Marriott, Location: Holiday Inn Capitol, 550 C Street SW., Washington, DC 20024. For up-to-date information, go to...

  2. 76 FR 2131 - Federal Radiological Preparedness Coordinating Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... place on January 20, 2011. The session open to the public will be from 9 a.m. EST to 10 a.m. EST. Send....m. EST to 10 a.m. EST, at the Crystal City Marriott at Reagan National Airport located at 1999... caption as soon as possible. Authority: 44 CFR 351.10(a) and 351.11(a). Timothy W. Manning, Deputy...

  3. The 28th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    Rohn, Douglas A. (Compiler)

    1994-01-01

    The proceedings of the 28th Aerospace Mechanisms Symposium, which was hosted by the NASA Lewis Research Center and held at the Cleveland Marriott Society Center on May 18, 19, and 20, 1994, are reported. Technological areas covered include actuators, aerospace mechanism applications for ground support equipment, lubricants, pointing mechanisms joints, bearings, release devices, booms, robotic mechanisms, and other mechanisms for spacecraft.

  4. 78 FR 66021 - National Cancer Institute; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, October 01, 2013, 08:00 a.m. to October 02, 2013, 05:00 p.m., Bethesda Marriott Hotel, 5151 Pooks Hill Road, Bethesda...

  5. Being Student and Practitioner Centered: Lessons Learned from Integrating a Recreation Management Department into a Business School

    ERIC Educational Resources Information Center

    Freeman, Patti A.; Duerden, Mat D.; Hill, Brian J.

    2016-01-01

    In July 2009, Brigham Young University's Recreation Management (RecM) Department moved to the Marriott School of Management (MSM), beginning its integration into a nationally ranked business school, including the transition from a college with little coordination between departments to one where all majors share a common core of classes. Despite…

  6. FHWA LTBP Bridge Performance Primer

    DOT National Transportation Integrated Search

    2014-02-01

    This TechBrief defines bridge performance and discusses the importance of measuring performance and current practices for doing so. It identifies key issues to improving performance measures and the role the Long-Term Bridge Performance (LTBP) Progra...

  7. Temporary bridge deck panels.

    DOT National Transportation Integrated Search

    2009-03-01

    The research described here has resulted in the development of a simplistic and innovative interlocking : glulam bridge deck panel for use in temporary bridge deck applications. The key feature of this panel : system is the interlocking tongue and gr...

  8. The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.

    PubMed

    Amaral, Nuno; Vendrell, Alexandre; Funaya, Charlotta; Idrissi, Fatima-Zahra; Maier, Michael; Kumar, Arun; Neurohr, Gabriel; Colomina, Neus; Torres-Rosell, Jordi; Geli, María-Isabel; Mendoza, Manuel

    2016-05-01

    Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response to chromosome segregation defects in yeast and animal cells. How chromatin bridges are detected, and whether abscission inhibition prevents their damage, remain key unresolved questions. We find that bridges induced by DNA replication stress and by condensation or decatenation defects, but not dicentric chromosomes, delay abscission in a NoCut-dependent manner. Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B. NoCut does not prevent DNA damage following condensin or topoisomerase II inactivation; however, it protects anaphase bridges and promotes cellular viability after replication stress. Therefore, the molecular origin of chromatin bridges is critical for activation of NoCut, which plays a key role in the maintenance of genome stability after replicative stress.

  9. Simple bridge security inspection : final report, September 2006.

    DOT National Transportation Integrated Search

    2006-09-01

    Bridges are among the most visible targets for terrorists since their destruction will have an : immediate as well as long-term economical and psychological impact on the nation. : Enhancing bridge security is key to improving homeland security and i...

  10. Rapid replacement/construction of bridges.

    DOT National Transportation Integrated Search

    2012-11-01

    Bridges are a key element of the transportation system because they control system capacity and are normally built at : the highest cost to the system. Once a bridge reaches its useful design service life, it needs to be replaced or : reconstructed i...

  11. 14th Annual Expeditionary Warfare Conference

    DTIC Science & Technology

    2009-11-19

    Untitled Document 2009expedition.html[5/12/2016 8:33:22 AM] 14th ANNUAL EXPEDITIONARY WARFARE CONFERENCE “Expeditionary Warfare in a Complex Joint...WWW.NDIA.ORG/MEETINGS/0700 “Expeditionary Warfare in a Complex Joint Operating Environment” BAY POINT MARRIOTT HOTEL, PANAMA CITY, FL...Focus: The purpose of the Quadrennial Defense Review (QDR) is to determine the nation’s defense strategy and establish a defense program for

  12. Adult Education between Cultures. Encounters and Identities in European Adult Education since 1890. Leeds Studies in Continuing Education. Cross-Cultural Studies in the Education of Adults, Number 2.

    ERIC Educational Resources Information Center

    Hake, Barry J., Ed.; Marriott, Stuart, Ed.

    This book contains the following papers from a European research seminar examining the history and theory of cross-cultural communication in adult education: "Introduction: Encounters and Identities in European Adult Education since 1890" (Barry J. Hake, Stuart Marriott); "The University Extension Movement (1892-1914) in Ghent,…

  13. 75 FR 71454 - Meeting of the California Desert District Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... lands on Friday, December 10, 2010, from 8 a.m. to 5 p.m. and will meet in formal session on Saturday, December 11, 2010, from 8 a.m. to 5 p.m. at the Riverside Marriott, 3400 Market Street, Riverside, CA 92501... BLM California state Web site at http://www.blm.gov/ca/st/en/info/rac/dac.html . SUPPLEMENTARY...

  14. 75 FR 56127 - Federal Radiological Preparedness Coordinating Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... place on September 28, 2010. The session is open to the public and will take place from 9 a.m. to 11 a.m... 351.10(a) and 351.11(a). The FRPCC is holding a public meeting on September 28, 2010, from 9 a.m. to 11 a.m., at the Marriott Crystal Gateway located at 1700 Jefferson Davis Highway, Arlington, VA 22202...

  15. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Special Assitant for STEM Education, U. S. Department of Education, Michael Lach, far right, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Seated from right are James Stofan, NASA Acting Associate Administrator for Education; Charles Bolden, NASA Administrator; and Cora B. Marrett, Acting Director, National Science Foundation. (Photo Credit: NASA/Carla Cioffi)

  16. Toward Successful Implementation of Prefabricated Deck Panels to Accelerate the Bridge Construction Process

    DOT National Transportation Integrated Search

    2016-08-01

    The development of accelerated bridge construction (ABC) techniques and connection details has become a national research focus. With the aging of the interstate system and many bridges on key routes requiring extensive rehabilitation or replacement,...

  17. 77 FR 9731 - Voluntary Service National Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ...) National Advisory Committee (NAC) will be held March 14-16, 2012, at the Charleston Marriott, 170 Lockwood Boulevard, Charleston, South Carolina. On March 14, the meeting will begin at 8 a.m. and end at 11:30 a.m. On March 15-16, the meeting will begin at 8:30 a.m. and end at 4:30 p.m. The meeting is open to the...

  18. Proceedings of the XIII International Symposium on Biological Control of Weeds; September 11-16, 2011; Waikoloa, Hawaii, USA

    Treesearch

    Yun Wu; Tracy Johnson; Sharlene Sing; S. Raghu; Greg Wheeler; Paul Pratt; Keith Warner; Ted Center; John Goolsby; Richard Reardon

    2013-01-01

    A total of 208 participants from 78 organizations in 19 countries gathered at the Waikoloa Beach Marriott on the Big Island of Hawaii on September 11-16, 2011 for the XIII International Symposium on Biological Control of Weeds. Following a reception on the first evening, Symposium co-chairs Tracy Johnson and Pat Conant formally welcomed the attendees on the morning of...

  19. Building Literacy Communities. The Thirty-Second Yearbook: A Doubled Peer Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Morrison, Timothy, Ed.; Martin, Linda, Ed.; Boggs, Merry, Ed.; Raine, I. LaVerne, Ed.

    2010-01-01

    For its 53rd annual meeting, the Association of Educators and Researchers met in Charlotte, North Carolina at the Marriott Charlotte City Center. This year's conference theme was "Building Literacy Communities", which was also used as the title for this year's Yearbook, Volume 32. This organization has long been the home of some of the nation's…

  20. 2006 Electrochemistry Gordon Research Conference - February 12-17-2006

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abruna, Hector D.

    The Gordon Research Conference (GRC) on Electrochemistry was held at Santa Ynez Valley Marriott, Buellton California from February 12-17, 2006. The Conference was well-attended with 113 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time formore » formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.« less

  1. High Performance Computing Operations Review Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cupps, Kimberly C.

    2013-12-19

    The High Performance Computing Operations Review (HPCOR) meeting—requested by the ASC and ASCR program headquarters at DOE—was held November 5 and 6, 2013, at the Marriott Hotel in San Francisco, CA. The purpose of the review was to discuss the processes and practices for HPC integration and its related software and facilities. Experiences and lessons learned from the most recent systems deployed were covered in order to benefit the deployment of new systems.

  2. Exploring the World of Literacy. The Thirty-Sixth Yearbook: A Doubled Peer-Reviewed Publication of the Association of Literacy Educators and Researchers

    ERIC Educational Resources Information Center

    Szabo, Susan, Ed.; Haas, Leslie, Ed.; Vasinda, Sheri, Ed.

    2014-01-01

    For their 57th annual conference, the Association of Literacy Educators and Researchers (ALER) met in Dallas, Texas at Addison Marriott Quorum by the Galleria. This year's conference theme was Exploring the World of Literacy, which was also used as the title for this year's Yearbook, Volume 36. Included are double-peer reviewed papers,…

  3. Standard plans for southern pine bridges

    Treesearch

    P. D. Hilbrich Lee; M. A. Ritter; M. H. Triche

    1995-01-01

    The development of standardized timber bridge plans and specifications is a key element in improving design and construction practices. The bridge plans presented were developed as a cooperative effort between the USDA Forest Service, Forest Products Laboratory (FPL); the University of Alabama; and the Southern Pine Council and are the first step in developing...

  4. Determination of Percent Body Fat Using 3D Whole Body Laser Scanning: A Preliminary Investigation

    DTIC Science & Technology

    2006-11-01

    S.B., Lohman, T.G., Wang, Z., and Going, S.B., 2005: Human body composition: Human Kinetics : Champaign, IL. Heyward, V.H. and Wagner, D.R...2004: Applied body composition assessment: Human Kinetics : Champaign, IL. Hodgdon, J.A., and Beckett, M.B., 1984a: Prediction of percent body fat...ethnicity. In: Human body Composition., Heymsfield, S.B., Lohman, T.G., Wang, Z., and Going, S.B (eds.). Human Kinetics : Champaign, IL. Marriott

  5. Proceedings of the Annual Symposium on Frequency Control (37th). 1-3 June 1983, Marriott Hotel, Philadelphia, Pennsylvania.

    DTIC Science & Technology

    1983-06-03

    current not power. inspection groups . The experimental procedure for the resistance TABLE I non -linearity inspection will be to condition the crystal...comparatively small [24]. By eali effect, the precision with which the effect micht controlling the experimental conditions we estimate be controlled ...intended to be a accepted on an individual basis for Group A predictor of long term performance. It is another testing. check on process control

  6. Committee on Military Nutrition Research Activity Report 1986 - 1992.

    DTIC Science & Technology

    1992-06-29

    AD-A252 884I HIIIElitEl111111ll1111lll COMMITTEE ON MILITARY NUTRITION RESEARCH DTIC- S ELECTE’ /JUL 1 41992. fox public zelease ond sle; itsd...SUBTITLE 5. FUNDING NUMBERS Committee on Military Nutrition Research DAMD17-86-G-6036 Activity Report 1986-1992 6. AUTHOR(S) work of: Committee on...Military Nutrition Research report prepared by: Bernadette M. Marriott and Robert Earl 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING

  7. Officers and Council, 1998-1999

    NASA Astrophysics Data System (ADS)

    1999-10-01

    The 1998-1999 Council of the British Astronomical Association photographed on the steps of Burlington House, London, on 1999 May 26. Front row, left to right: Bob Marriott, Hazel McGee, Martin Mobberley, Nick James, Jonathan Shanklin, Ron Johnson; centre: Richard Miles, Gordon Taylor, Jacqueline Mitton, David Tucker, John Mason, Pat Barber, David Reid, Peter Hudson; back: Laurence Anslow, Guy Hurst, Lionel Mayling, Nick Hewitt, Owen Brazell, Tony Kinder, Mark Armstrong, Maurice Gavin. Photo by Hazel McGee and Linda Newton.

  8. The Shock and Vibration Digest. Volume 18, Number 10

    DTIC Science & Technology

    1986-10-01

    STRUCTURAL SYSTEMS BRIDGES 86-1882 Analysis of the Observed Seismic Response of a Highway Bridge J.C. Wilson 34 ■>:--;■- fWVW^VWUiWlWWI...3), pp 339-354 (May-June 1986) 10 fig«, 6 table«, 24 ref« KEY WORDS; Bridge «, Seumic re»pon«e, Sy«tem identification techniques...Strong-motion accelerograms obtained on separa- tion bridge during a 19 79 California earthquake are used to examine the response of this multi- ple

  9. 78 FR 13747 - Safety Advisory 2013-01; Passing Stop Signals Protecting Movable Bridges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... 82 freight cars, including 51 hazardous materials tank cars, derailed seven cars while crossing a... bridge to close using the key pad on the locomotive radio. Through the use of a programmable logic...

  10. Development and Validation of a Light Weight, Energy Dense, Ready to Eat (RTE) Bar

    DTIC Science & Technology

    2010-11-01

    Erythropoietin SMP – Skim Milk Powder EVOH - Ethylene Vinyl Alcohol FFM – Fat Free Mass GRAS – General Recognized As Safe HFCS – High Fructose Corn Syrup...to loss in lean muscle mass, and impaired physical and cognitive performance (Marriott 1995). A loss of fat free mass ( FFM ) can also be interpreted...was reported that the soldiers lost an average of 4.02kg +/- 1.42kg in FFM during the first three months of the experiment. This portion of the

  11. JANNAF 35th Combustion Subcommittee and 17th Propulsion Systems Hazards Subcommittee Meeting: Joint Sessions

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    This publication is a compilation of 15 unclassified/unlimited technical papers presented at the 1998 meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Combustion Subcommittee (CS) and Propulsion Systems Hazards Subcommittee (PSHS) held jointly with the Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7 - 11 December 1 998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include advanced ingredients and reaction kinetics in solid propellants and experimental diagnostic techniques.

  12. Efforts to Bridge the Gap between Research and Practice in Social Work: Precedents and Prospects: Keynote Address at the Bridging the Gap Symposium

    ERIC Educational Resources Information Center

    Rubin, Allen

    2015-01-01

    This keynote address discusses previous and ongoing efforts to reduce the persistent gap between research and practice in social work and offers recommendations for further bridging that gap. Key among those recommendations is the need to conduct descriptive outcome studies of efforts to adapt research-supported interventions in everyday practice…

  13. 33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

  14. 33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

  15. 33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... draw shall open on the quarter and three-quarter hour. (u) Flagler Memorial (SR A1A) bridge, mile 1020... (SR 700/80) bridge, mile 1024.7 at Palm Beach. The draw shall open on the quarter and three-quarter... open on the quarter and three-quarter-hour. (z-2) Linton Boulevard bridge, mile 1041.1, at Delray Beach...

  16. Superhydrophobic engineered cementitious composites for highway bridge applications : technology transfer and implementation.

    DOT National Transportation Integrated Search

    2013-09-01

    The strength and durability of highway bridges are two of the key components in maintaining a : high level of freight transportation capacity on the nations highways. Superhydrophobic : engineered cementitious composite (SECC) is a new advanced con...

  17. Improved connection details for adjacent prestressed bridge beams.

    DOT National Transportation Integrated Search

    2015-03-01

    Bridges with adjacent box beams and voided slabs are simply and rapidly constructed, and are well suited to : short to medium spans. The traditional connection between the adjacent members is a shear key lled with a : conventional non-shrink grout...

  18. Proof of concept for using unmanned aerial vehicles for high mast pole and bridge inspections.

    DOT National Transportation Integrated Search

    2015-06-01

    Bridges and high mast luminaires (HMLs) are key components of transportation infrastructures. Effective inspection : processes are crucial to maintain the structural integrity of these components. The most common approach for : inspections is visual ...

  19. Properties of Anchor Rods Removed from San Francisco-Oakland Bay Bridge

    DOT National Transportation Integrated Search

    2015-08-01

    In March 2013, the construction contractor for the new self-anchored suspension bridge between San Francisco and Oakland, California, tensioned the threaded rods between the bearings/shear keys and the concrete pier cap. Within days of completion, it...

  20. Modeling Security Bridge Certificate Authority Architecture

    NASA Astrophysics Data System (ADS)

    Ren, Yizhi; Li, Mingchu; Sakurai, Kouichi

    Current Public Key Infrastructures suffer from a scaling problem, and some may have security problems, even given the topological simplification of bridge certification authorities. This paper analyzes the security problems in Bridge Certificate Authorities (BCA) model by using the concept of “impersonation risk, ” and proposes a new modified BCA model, which enhances its security, but is a bit more complex incertification path building and implementation than the existing one.

  1. Development of an engineered cementitious composite to enhance bridge approach slab durability.

    DOT National Transportation Integrated Search

    2013-06-01

    The strength and durability of highway bridges are two of the key components in maintaining a : high level of freight transportation capacity on the nations highways. : The CFIRE project 04-09 demonstrated the feasibility of a new hybrid engineered...

  2. The Status and Prospect of Research into Protective Structures of Bridge Piers against Rockfall Impact

    NASA Astrophysics Data System (ADS)

    Gao, Liang; Zhang, Shan; Zhang, Junfa; Wu, Xiangnan

    2017-06-01

    Rockfall impact on bridge piers threats severely the mountain bridge structures of lifeline engineering. Intended for mountain bridge pier protection against rockfall impact, the paper conducted comprehensive reviews on the research status of impact effects, anti-collision structure, impact response to rockfall, and protective design at home and abroad, and proposed a new-type protective structure against rockfall impact. In addition, the paper carried out deep studies on such key scientific issues as impact effect calculation, protective materials against rockfall impact, damage mechanism of protective units, and parameter optimization on the system of protective structures against rockfall impact as well, aiming to strength disaster prevention of mountain bridge structures.

  3. Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis.

    PubMed

    Goupil, Eugénie; Amini, Rana; Hall, David H; Labbé, Jean-Claude

    2017-12-15

    Stable cytoplasmic bridges arise from failed cytokinesis, the last step of cell division, and are a key feature of syncytial architectures in the germline of most metazoans. Whereas the Caenorhabditis elegans germline is syncytial, its formation remains poorly understood. We found that the germline precursor blastomere, P 4 , fails cytokinesis, leaving a stable cytoplasmic bridge between the two daughter cells, Z 2 and Z 3 Depletion of several regulators of actomyosin contractility resulted in a regression of the membrane partition between Z 2 and Z 3 , indicating that they are required to stabilize the cytoplasmic bridge. Epistatic analysis revealed a pathway in which Rho regulators promote accumulation of the nonc annonical anillin ANI-2 at the stable cytoplasmic bridge, which in turns promotes the accumulation of the nonm uscle myosin II NMY-2 and the midbody component CYK-7 at the bridge, in part by limiting the accumulation of canonical anillin ANI-1. Our results uncover key steps in C. elegans germline formation and define a set of conserved regulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its stability during embryonic development. © 2017 Goupil, Amini, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  4. Electrical Actuation Technology Bridging

    NASA Technical Reports Server (NTRS)

    Hammond, Monica (Compiler); Sharkey, John (Compiler)

    1993-01-01

    This document contains the proceedings of the NASA Electrical Actuation Technology Bridging (ELA-TB) Workshop held in Huntsville, Alabama, September 29-October 1, 1992. The workshop was sponsored by the NASA Office of Space Systems Development and Marshall Space Flight Center (MSFC). The workshop addressed key technologies bridging the entire field of electrical actuation including systems methodology, control electronics, power source systems, reliability, maintainability, and vehicle health management with special emphasis on thrust vector control (TVC) applications on NASA launch vehicles. Speakers were drawn primarily from industry with participation from universities and government. In addition, prototype hardware demonstrations were held at the MSFC Propulsion Laboratory each afternoon. Splinter sessions held on the final day afforded the opportunity to discuss key issues and to provide overall recommendations. Presentations are included in this document.

  5. Electrical Actuation Technology Bridging

    NASA Astrophysics Data System (ADS)

    Hammond, Monica; Sharkey, John

    1993-05-01

    This document contains the proceedings of the NASA Electrical Actuation Technology Bridging (ELA-TB) Workshop held in Huntsville, Alabama, September 29-October 1, 1992. The workshop was sponsored by the NASA Office of Space Systems Development and Marshall Space Flight Center (MSFC). The workshop addressed key technologies bridging the entire field of electrical actuation including systems methodology, control electronics, power source systems, reliability, maintainability, and vehicle health management with special emphasis on thrust vector control (TVC) applications on NASA launch vehicles. Speakers were drawn primarily from industry with participation from universities and government. In addition, prototype hardware demonstrations were held at the MSFC Propulsion Laboratory each afternoon. Splinter sessions held on the final day afforded the opportunity to discuss key issues and to provide overall recommendations. Presentations are included in this document.

  6. Determining the cost/benefit of routine maintenance cleaning on steel bridges to prevent structural deterioration.

    DOT National Transportation Integrated Search

    2013-09-01

    This study was conducted in cooperation with the U.S. Department of Transportation, Federal Highway Administration. The objective of this study is to identify the key variables necessary in estimating the impact of regular washing of steel bridges on...

  7. 33 CFR 117.484 - Pass Manchac.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... lights will be lit, and photoelectric (infrared) boat detectors will monitor the waterway beneath the... sequences. (Estimated duration that the bridge will remain closed for passage of rail traffic is 10 to 12 minutes.) The bridge will also be manually operable from two locked trackside control locations (key...

  8. 33 CFR 117.484 - Pass Manchac.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... lights will be lit, and photoelectric (infrared) boat detectors will monitor the waterway beneath the... sequences. (Estimated duration that the bridge will remain closed for passage of rail traffic is 10 to 12 minutes.) The bridge will also be manually operable from two locked trackside control locations (key...

  9. Air Pollution and Health: Bridging the Gap from Health Outcomes: Conference Summary

    EPA Science Inventory

    “Air Pollution and Health: Bridging the Gap from Sources to Health Outcomes,” an international specialty conference sponsored by the American Association for Aerosol Research, was held to address key uncertainties in our understanding of adverse health effects related to air po...

  10. Recent research and applications of numerical simulation for dynamic response of long-span bridges subjected to multiple loads.

    PubMed

    Chen, Zhiwei; Chen, Bo

    2014-01-01

    Many long-span bridges have been built throughout the world in recent years but they are often subject to multiple types of dynamic loads, especially those located in wind-prone regions and carrying both trains and road vehicles. To ensure the safety and functionality of these bridges, dynamic responses of long-span bridges are often required for bridge assessment. Given that there are several limitations for the assessment based on field measurement of dynamic responses, a promising approach is based on numerical simulation technologies. This paper provides a detailed review of key issues involved in dynamic response analysis of long-span multiload bridges based on numerical simulation technologies, including dynamic interactions between running trains and bridge, between running road vehicles and bridge, and between wind and bridge, and in the wind-vehicle-bridge coupled system. Then a comprehensive review is conducted for engineering applications of newly developed numerical simulation technologies to safety assessment of long-span bridges, such as assessment of fatigue damage and assessment under extreme events. Finally, the existing problems and promising research efforts for the numerical simulation technologies and their applications to assessment of long-span multiload bridges are explored.

  11. Recent Research and Applications of Numerical Simulation for Dynamic Response of Long-Span Bridges Subjected to Multiple Loads

    PubMed Central

    Chen, Zhiwei; Chen, Bo

    2014-01-01

    Many long-span bridges have been built throughout the world in recent years but they are often subject to multiple types of dynamic loads, especially those located in wind-prone regions and carrying both trains and road vehicles. To ensure the safety and functionality of these bridges, dynamic responses of long-span bridges are often required for bridge assessment. Given that there are several limitations for the assessment based on field measurement of dynamic responses, a promising approach is based on numerical simulation technologies. This paper provides a detailed review of key issues involved in dynamic response analysis of long-span multiload bridges based on numerical simulation technologies, including dynamic interactions between running trains and bridge, between running road vehicles and bridge, and between wind and bridge, and in the wind-vehicle-bridge coupled system. Then a comprehensive review is conducted for engineering applications of newly developed numerical simulation technologies to safety assessment of long-span bridges, such as assessment of fatigue damage and assessment under extreme events. Finally, the existing problems and promising research efforts for the numerical simulation technologies and their applications to assessment of long-span multiload bridges are explored. PMID:25006597

  12. Vision 2000: Strategies for a New Millennium, Proceedings: Military Librarians Workshop 󈨥. 41st Annual Military Librarians Workshop, 18-20 November 1997, Marriott Hotel, Dayton, Ohio.

    DTIC Science & Technology

    1997-12-01

    Science Foundation, the development of a topography of STI systems for the Library of Congress, and the development of a system to provide input to...Information System’s Database and a project to develop a reference catalog of Internet resources in area studies. She is consultant to foreign and...interface development for non-US data. Prior to this, she served as the Director of Corporate Librarian Relations, developing marketing, support, and new

  13. U.S. Department of Energy Hydrogen and Fuel Cells Program 2014 Annual Merit Review and Peer Evaluation Report: June 16-20, 2014, Washington, D.C.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2014-10-01

    The fiscal year (FY) 2014 U.S. Department of Energy (DOE) Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting (AMR), in conjunction with DOE's Vehicle Technologies Office AMR, was held from June 16-20, 2014, at the Washington Marriott Wardman Park in Washington, D.C. This report is a summary of comments by AMR peer reviewers about the hydrogen and fuel cell projects funded by DOE's Office of Energy Efficiency and Renewable Energy (EERE).

  14. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Student Ambassadors and Facilitator are seen on a panel at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. From left to right are: Quenton Bonds, University of South Florida; Geoffrey Wawrzyniak, Purdue University; Heriberto Reynoso, University of Texas at Brownsville; Marie Kingbird-Lowry, Leech Lake Tribal College; Kareen Borders, University of Washington; Katelyn Doran, University of North Carolina at Charlotte and Ashanti Johnson, PhD, Executive Director, Institute for Broadening Participation. (Photo Credit: NASA/Carla Cioffi)

  15. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Administrator Charles Bolden, far right, gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Administrator Bolden is joined on the panel from left to right by Leland Melvin, Education Design Team Co-Chair and NASA Astronaut; William Kelly, Manager, Public Affairs, American Society for Engineering Education; Michael Lach, Special Assistant for STEM Education, U.S. Department of Education; Cora Marrett, Acting Director, National Science Foundation; and James Stofan, NASA Acting Associate Administrator for Education. (Photo Credit: NASA/Carla Cioffi)

  16. Return to Beringia: parasites reveal cryptic biogeographic history of North American pikas

    USDA-ARS?s Scientific Manuscript database

    As a dispersal corridor between the northern continents, the Bering Land Bridge played a key role in shaping Holarctic biotas. The Beringian paradigm identifies the land bridge as a zone of predominantly eastward expansion from Eurasia and a staging area for subsequent colonization of lower latitude...

  17. 33 CFR 117.272 - Boot Key Harbor.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Boot Key Harbor. 117.272 Section 117.272 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.272 Boot Key Harbor. The draw of the Boot Key Harbor drawbridge, mile 0.13, between...

  18. In-Place Preservative Treatments for Covered Bridges

    Treesearch

    Stan Lebow; Jeff Morrell

    2014-01-01

    Covered bridges can be vulnerable to damage from fungal decay and insect attack. This paper describes procedures for selecting and applying in-place treatments to prevent or arrest biodegradation, and summarizes recent research evaluating some of these treatments. Wood moisture is the key to decay and termite attack, and the first line of defense against...

  19. Electrical actuation technology bridging, volume 1

    NASA Astrophysics Data System (ADS)

    Hammond, Monica S.; Doane, George B., III

    1993-01-01

    This document contains the proceedings from the conference. The workshop addressed key technologies bridging the entire field of electrical actuation including systems methodology, control electronics, power source systems, reliability, maintainability, and vehicle health management with special emphasis on thrust vector control (TVC) applications on NASA launch vehicles. Speakers were drawn primarily from industry with participation from universities and government. In addition, prototype hardware demonstrations were held at the MSFC Propulsion Laboratory each afternoon. Splinter sessions held on the final day afforded the opportunity to discuss key issues and to provide overall recommendations. Presentations are included in this document.

  20. Two Alternative Approaches to Creating Opportunities for Entrepreneurial Activity: Bridging the Divide between Academics and Entrepreneurs.

    ERIC Educational Resources Information Center

    Weaver, K. Mark

    1993-01-01

    This article shows how the Norwegian Small Business Research Center and the Alabama International Trade Center have set goals and established procedures to bridge gaps and correct misconceptions between academics and entrepreneurs. Keys to formation of both organizations were involvement of well-thought of universities, a willingness to take a…

  1. Collaborative Writing: Bridging the Gap between the Textbook and the Workplace

    ERIC Educational Resources Information Center

    Bremner, Stephen

    2010-01-01

    A key challenge facing professional communication teachers is the need to bridge the gap between the culture of the classroom and the reality of the workplace. One area of difference between the two contexts is the way in which collaborative activities surrounding the construction of written text are enacted. Differences in collaborative practices…

  2. Monitoring and Evaluation of a Long-Span Raiway Bridge Using SENTINEL-1 Data

    NASA Astrophysics Data System (ADS)

    Huang, Q.; Crosetto, M.; Monserrat, O.; Crippa, B.

    2017-09-01

    This paper is focused on displacement monitoring of a bridge, which is one of the key aspects of its structural health monitoring. A simplified Persistent Scatterer Interferometry (PSI) approach is used to monitor the displacements of the Nanjing Dashengguan Yangtze River High-speed Railway Bridge (China). This bridge is 1272 m long and hosts a total of 6 railway lines. The analysis was based on a set of twenty-nine Sentinel-1A images, acquired from April 2015 to August 2016. A dense set of measurement points were selected on the bridge. The PSI results show a maximum longitudinal displacement of 150 mm, on each side of the bridge. The displacements are strongly correlated with the temperature, showing that they are due to thermal expansion. Using the PSI results, the Coefficient of Thermal Expansion (CTE) of the whole bridge was estimated. The result agrees well with the CTE of the bridge materials. Using a regression model, the PSI-measured displacements were compared with in-situ measurements. The paper proposes a procedure to assess the performance of the movable bearings of the bridge, which is based on the PSI measurements.

  3. 2013 MOLECULAR ENERGY TRANSFER GORDON RESEARCH CONFERENCE (JANUARY 13-18, 2013 - VENTURA BEACH MARRIOTT, VENTURA CA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reid, Scott A.

    2012-10-18

    Sessions covered all areas of molecular energy transfer, with 10 sessions of talks and poster sessions covering the areas of :  Energy Transfer in Inelastic and Reactive Scattering  Energy Transfer in Photoinitiated and Unimolecular Reactions  Non-adiabatic Effects in Energy Transfer  Energy Transfer at Surfaces and Interfaces  Energy Transfer in Clusters, Droplets, and Aerosols  Energy Transfer in Solution and Solid  Energy Transfer in Complex Systems  Energy Transfer: New vistas and horizons  Molecular Energy Transfer: Where Have We Been and Where are We Going?

  4. JANNAF Airbreathing Propulsion Subcommittee and 35th Combustion Subcommittee Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    This document, CPIA Publication 682, Volume 1, is a compilation of 5 unclassified/unlimited technical papers (approved for public release) which were presented at the 1 998 meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Airbreathing Propulsion Subcommittee (APS) and Combustion Subcommittee (CS) held jointly with the Propulsion Systems Hazards Subcommittee (PSHS). The meeting was held on 7-11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include HyTech technology development, hydrocarbon fuel development for hypersonic applications, pulse detonation propulsion system development and arc heaters for direct-connect scramjet testing.

  5. KSC-2014-2038

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., James Mantovani of the NASA Surface Systems Office at NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  6. KSC-2014-2036

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Tom Engler, deputy director of Center Planning and Development at NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  7. KSC-2014-2040

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Janet Petro, deputy director of NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  8. KSC-2014-2041

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Janet Petro, deputy director of NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  9. KSC-2014-2043

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Janet Petro, deputy director of NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  10. KSC-2014-2045

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Karen Thompson, NASA's chief technologist at the Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  11. KSC-2014-2042

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Janet Petro, deputy director of NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  12. KSC-2014-2037

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Tom Engler, deputy director of Center Planning and Development at NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  13. KSC-2014-2044

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Karen Thompson, NASA's chief technologist at the Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  14. KSC-2014-2039

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., James Mantovani of the NASA Surface Systems Office at NASA's Kennedy Space Center, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  15. Albuquerque Regional Training: The Third Seminar on Surface Metrology for the Americas May 12-13 2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tran, Sophie M; Tran, Hy D.

    The Third Seminar on Surface Metrology for the Americas (SSMA) took place in Albuquerque, New Mexico May 12-13, 2014. The conference was at the Marriott Hotel, in the heart of Albuquerque Uptown, within walking distance of many fantastic restaurants. Why surface metrology? Ask Professor Chris Brown of Worcester Polytechnic Institute (WPI), the chair of the first two SSMAs in 2011 and 2012 and the chair of the ASME B46 committee on classification and designation of surface qualities, and Professor Brown responds: “Because surfaces cover everything.”

  16. Removal of failed crown and bridge

    PubMed Central

    Rahul, G R.; Poduval, Soorya T.; Shetty, Karunakar

    2012-01-01

    Crown and bridge have life span of many years but they fail for a number of reasons. Over the years, many devices have been designed to remove crowns and bridges from abutment teeth. While the removal of temporary crowns and bridges is usually very straightforward, the removal of a definitive cast crown with unknown cement is more challenging. Removal is often by destructive means. There are a number of circumstances, however, in which conservative disassembly would aid the practitioner in completing restorative/endodontic procedures. There are different mechanisms available to remove a failed crown or bridge. But there is no information published about the classification of available systems for crown and bridge removal. So it is logical to classify these systems into different groups which can help a clinician in choosing a particular type of system depending upon the clinical situation. The aim of this article is to provide a classification for various crown and bridge removal systems; describe how a number of systems work; and when and why they might be used. A PubMed search of English literature was conducted up to January 2010 using the terms: Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure. Additionally, the bibliographies of 3 previous reviews, their cross references as well as articles published in various journals like International Endodontic Journal, Journal of Endodontics and were manually searched. Key words:Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure. PMID:24558549

  17. Evidence-Based Practice in Autism Educational Research: Can We Bridge the Research and Practice Gap?

    ERIC Educational Resources Information Center

    Guldberg, Karen

    2017-01-01

    In order to develop deeper and better understandings of what constitutes effective educational practices, and to bridge the gap between research and practice, there is a need for a paradigm shift in autism educational research. The contribution of this paper is to examine the key methodological challenges that stand in the way of autism…

  18. Building the Bridge between Science and Practice: Essential Characteristics of a Translational Framework

    ERIC Educational Resources Information Center

    Stafford-Brizard, K. Brooke; Cantor, Pamela; Rose, L. Todd

    2017-01-01

    Mind, brain, and education is a field developed with two key purposes: (1) to accelerate the knowledge developed through research by using an interdisciplinary approach, and (2) to create a bridge to connect and apply this knowledge to educational practice. While great progress has been made with regard to the interdisciplinary efforts of mind,…

  19. Development of a smart timber bridge - a five-year plan

    Treesearch

    Brent M. Phares; Terry J. Wipf; Ursula Deza; James P. Wacker

    2011-01-01

    This paper outlines a 5-year research plan for the development of a structural health monitoring system for timber bridges. A series of studies identify and evaluate various sensing technologies for measurement of structural adequacy and/or deterioration parameters. The overall goal is to develop a turn-key system to analyze, monitor, and report on the performance and...

  20. Boundary Spanners as Bridges of Student and School Discourses in an Urban Science and Mathematics High School

    ERIC Educational Resources Information Center

    Buxton, Cory A.; Carlone, Heidi B.; Carlone, David

    2005-01-01

    A key to improving urban science and mathematics education is to facilitate the mutual understanding of the participants involved and then look for strategies to bridge differences. Educators need new theoretical tools to do so. In this paper the argument is made that the concept of "boundary spanner" is such a tool. Boundary spanners…

  1. Bridges to the Doctorate: mentored transition to successful completion of doctoral study for underrepresented minorities in nursing science.

    PubMed

    Kim, Mi Ja; Holm, Karyn; Gerard, Peggy; McElmurry, Beverly; Foreman, Mark; Poslusny, Susan; Dallas, Constance

    2009-01-01

    Nursing has a shortage of doctorally-prepared underrepresented minority (URM) scientists/faculty. We describe a five-year University of Illinois at Chicago (UIC) Bridges program for URM master's students' transition to doctoral study and factors in retention/graduation from the PhD program. Four master' students from two partner schools were recruited/appointed per year and assigned UIC faculty advisors. They completed 10 UIC credits during master's study and were mentored by Bridges faculty. Administrative and financial support was provided during transition and doctoral study. Partner schools' faculty formed research dyads with UIC faculty. Seventeen Bridges students were appointed to the Bridges program: 12 were admitted to the UIC PhD program since 2004 and one graduated in 2007. Eight Bridges faculty research dyads published 5 articles and submitted 1 NIH R03 application. Mentored transition from master's through doctoral program completion and administrative/financial support for students were key factors in program success. Faculty research dyads enhanced the research climate in partner schools.

  2. Research on Swivel Construction Technology of 22,400 Tons in Zoucheng Thirty Meter Bridge

    NASA Astrophysics Data System (ADS)

    Han, Jun; Benlin, Xiao

    2018-05-01

    In recent years, with the rapid development of highways and railways in our country, there have been many new bridges that need to cross the existing routes. If the conventional construction methods are used, the existing traffic will be affected and the traffic will be built above the busy traffic lines, so there is a big security risk, the construction methods must be improved and innovated. In this paper, it intends to research and develop some key technologies of swivel construction. According to the construction features to use finite element method of swivel cable-stayed bridge to analyse the cable-stayed bridge . The swivel construction process is carried out to solve the technical problems and difficulties in the construction.

  3. Experimental and Analytical Seismic Studies of a Four-Span Bridge System with Innovative Materials

    NASA Astrophysics Data System (ADS)

    Cruz Noguez, Carlos Alonso

    As part of a multi-university project utilizing the NSF Network for Earthquake Engineering Simulation (NEES), a quarter-scale model of a four-span bridge incorporating plastic hinges with different advanced materials was tested to failure on the three shake table system at the University of Nevada, Reno (UNR). The bridge was the second test model in a series of three 4-span bridges, with the first model being a conventional reinforced-concrete (RC) structure. The purpose of incorporating advanced materials was to improve the seismic performance of the bridge with respect to two damage indicators: (1) column damage and (2) permanent deformations. The goals of the study presented in this document were to (1) evaluate the seismic performance of a 4-span bridge system incorporating SMA/ECC and built-in rubber pad plastic hinges as well as post-tensioned piers, (2) quantify the relative merit of these advanced materials and details compared to each other and to conventional reinforced concrete plastic hinges, (3) determine the influence of abutment-superstructure interaction on the response, (4) examine the ability of available elaborate analytical modeling techniques to model the performance of advanced materials and details, and (5) conduct an extensive parametric study of different variations of the bridge model to study several important issues in bridge earthquake engineering. The bridge model included six columns, each pair of which utilized a different advanced detail at bottom plastic hinges: shape memory alloys (SMA), special engineered cementitious composites (ECC), elastomeric pads embedded into columns, and post-tensioning tendons. The design of the columns, location of the bents, and selection of the loading protocol were based on pre-test analyses conducted using computer program OpenSees. The bridge model was subjected to two-horizontal components of simulated earthquake records of the 1994 Northridge earthquake. Over 340 channels of data were collected. The test results showed the effectiveness of the advanced materials in reducing damage and permanent displacements. The damage was minimal in plastic hinges with SMA/ECC and those with built-in elastomeric pads. Conventional RC plastic hinges were severely damaged due to spalling of concrete and rupture of the longitudinal and transverse reinforcement. Extensive post-test analytical studies were conducted and it was determined that a computational model of the bridge that included bridge-abutment interaction using OpenSees was able to provide satisfactory estimations of key structural parameters such as superstructure displacements and base shears. The analytical model was also used to conduct parametric studies on single-column and bridge-system response under near-fault ground motions. The effects of vertical excitations and transverse shear-keys at the bridge abutments on the superstructure displacement and column drifts were also explored.

  4. A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges.

    PubMed

    Rehain-Bell, Kathryn; Love, Andrew; Werner, Michael E; MacLeod, Ian; Yates, John R; Maddox, Amy Shaub

    2017-03-20

    Germ cells in most animals are connected by intercellular bridges, actin-based rings that form stable cytoplasmic connections between cells promoting communication and coordination [1]. Moreover, these connections are required for fertility [1, 2]. Intercellular bridges are proposed to arise from stabilization of the cytokinetic ring during incomplete cytokinesis [1]. Paradoxically, proteins that promote closure of cytokinetic rings are enriched on stably open intercellular bridges [1, 3, 4]. Given this inconsistency, the mechanism of intercellular bridge stabilization is unclear. Here, we used the C. elegans germline as a model for identifying molecular mechanisms regulating intercellular bridges. We report that bridges are actually highly dynamic, changing size at precise times during germ cell development. We focused on the regulation of bridge stability by anillins, key regulators of cytokinetic rings and cytoplasmic bridges [1, 4-7]. We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin interactor. GCK-1 works together with CCM-3, a known binding partner [9], to promote intercellular bridge stability and limit localization of both canonical anillin and non-muscle myosin II (NMM-II) to intercellular bridges. Additionally, we found that a shorter anillin, known to stabilize bridges [4, 7], also regulates NMM-II levels at bridges. Consistent with these results, negative regulators of NMM-II stabilize intercellular bridges in the Drosophila egg chamber [10, 11]. Together with our findings, this suggests that tuning of myosin levels is a conserved mechanism for the stabilization of intercellular bridges that can occur by diverse molecular mechanisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. 14 CFR 1216.203 - Definition of key terms.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Floodplain and Wetlands Management § 1216.203 Definition of key terms. (a) Action—any NASA activity including... buildings, structures and utility items, marine structures, bridges and other land development items, such... wetlands. (i) Floodproofing—the modification of individual structures and facilities, their sites, and...

  6. An Undergraduate Course to Bridge the Gap between Textbooks and Scientific Research

    ERIC Educational Resources Information Center

    Wiegant, Fred; Scager, Karin; Boonstra, Johannes

    2011-01-01

    This article reports on a one-semester Advanced Cell Biology course that endeavors to bridge the gap between gaining basic textbook knowledge about cell biology and learning to think and work as a researcher. The key elements of this course are 1) learning to work with primary articles in order to get acquainted with the field of choice, to learn…

  7. Bridging East and West--Or, a Bridge Too Far? Paulo Freire and the "Tao Te Ching"

    ERIC Educational Resources Information Center

    Roberts, Peter

    2012-01-01

    This article considers key differences and similarities between Freirean and Taoist ideals. I limit my focus to the "Tao Te Ching" (attributed to Lao Tzu), paying brief attention to the origins of this classic work of Chinese philosophy before concentrating on several themes of relevance to Freire's work. An essay by James Fraser (1997), who makes…

  8. Displacement monitoring and modelling of a high-speed railway bridge using C-band Sentinel-1 data

    NASA Astrophysics Data System (ADS)

    Huang, Qihuan; Crosetto, Michele; Monserrat, Oriol; Crippa, Bruno

    2017-06-01

    Bridge displacement monitoring is one of the key components of bridge structural health monitoring. Traditional methods, usually based on limited sets of sensors mounted on a given bridge, collect point-like deformation information and have the disadvantage of providing incomplete displacement information. In this paper, a Persistent Scatterer Interferometry (PSI) approach is used to monitor the displacements of the Nanjing Dashengguan Yangtze River high-speed railway bridge. Twenty-nine (29) European Space Agency Sentinel-1A images, acquired from April 25, 2015 to August 5, 2016, were used in the PSI analysis. A total of 1828 measurement points were selected on the bridge. The results show a maximum longitudinal displacement of about 150 mm on each side of the bridge. The measured displacements showed a strong correlation with the environmental temperature at the time the images used were acquired, indicating that they were due to thermal expansion of the bridge. At each pier, a regression model based on the PSI-measured displacements was compared with a model based on in-situ measurements. The good agreement of these models demonstrates the capability of the PSI technique to monitor long-span railway bridge displacements. By comparing the modelled displacements and dozens of PSI measurements, we show how the performance of movable bearings can be evaluated. The high density of the PSI measurement points is advantageous for the health monitoring of the entire bridge.

  9. Salt-bridge networks within globular and disordered proteins: characterizing trends for designable interactions.

    PubMed

    Basu, Sankar; Mukharjee, Debasish

    2017-07-01

    There has been considerable debate about the contribution of salt bridges to the stabilization of protein folds, in spite of their participation in crucial protein functions. Salt bridges appear to contribute to the activity-stability trade-off within proteins by bringing high-entropy charged amino acids into close contacts during the course of their functions. The current study analyzes the modes of association of salt bridges (in terms of networks) within globular proteins and at protein-protein interfaces. While the most common and trivial type of salt bridge is the isolated salt bridge, bifurcated salt bridge appears to be a distinct salt-bridge motif having a special topology and geometry. Bifurcated salt bridges are found ubiquitously in proteins and interprotein complexes. Interesting and attractive examples presenting different modes of interaction are highlighted. Bifurcated salt bridges appear to function as molecular clips that are used to stitch together large surface contours at interacting protein interfaces. The present work also emphasizes the key role of salt-bridge-mediated interactions in the partial folding of proteins containing long stretches of disordered regions. Salt-bridge-mediated interactions seem to be pivotal to the promotion of "disorder-to-order" transitions in small disordered protein fragments and their stabilization upon binding. The results obtained in this work should help to guide efforts to elucidate the modus operandi of these partially disordered proteins, and to conceptualize how these proteins manage to maintain the required amount of disorder even in their bound forms. This work could also potentially facilitate explorations of geometrically specific designable salt bridges through the characterization of composite salt-bridge networks. Graphical abstract ᅟ.

  10. Microstructural processes in irradiated materials

    NASA Astrophysics Data System (ADS)

    Byun, Thak Sang; Kaoumi, Djamel; Bai, Xian-Ming

    2017-12-01

    The 8th symposium on Microstructural Progresses in Irradiated Materials (MPIM) was held at San Diego Convention Center and Marriott Marquis & Marina, San Diego, California, USA, February 26-March 2, 2017, as part of the TMS 2017 146th Annual Meeting and Exhibition. Since 2003, when the first MPIM symposium was held in the same place, the symposium has been held in odd years and has grown to one of the biggest symposia in the TMS Annual Meeting which invites more than sixty symposia. In the 8th MPIM symposium, a total of 106 oral and poster presentations, including 16 invited talks, were delivered for 4 days.

  11. Proceedings of the 4th International Conference and Exhibition: World Congress on Superconductivity, volume 1

    NASA Technical Reports Server (NTRS)

    Krishen, Kumar (Editor); Burnham, Calvin (Editor)

    1995-01-01

    The papers presented at the 4th International Conference Exhibition: World Congress on Superconductivity held at the Marriott Orlando World Center, Orlando, Florida, are contained in this document and encompass the research, technology, applications, funding, political, and social aspects of superconductivity. Specifically, the areas covered included: high-temperature materials; thin films; C-60 based superconductors; persistent magnetic fields and shielding; fabrication methodology; space applications; physical applications; performance characterization; device applications; weak link effects and flux motion; accelerator technology; superconductivity energy; storage; future research and development directions; medical applications; granular superconductors; wire fabrication technology; computer applications; technical and commercial challenges, and power and energy applications.

  12. Key participants in codeveloped technology pose for group picture

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Following the presentation of the Universal Signal Conditioning Amplifier (USCA), a new piece of technology developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr., key participants in the partnership pose for a group portrait. They are (from left) Bill Larson, NASA; Dr. Pedro Medelius, INET; Roy Bridges, Jr., KSC Director; Ed Gladney and William Saputo, L-3 Communications; Pam Gillespi, representing Congressman Dave Weldon; and Frank Kinney, Technological Research and Development Authority. The USCA is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets.

  13. Assessment of the integrity of concrete bridge structures by acoustic emission technique

    NASA Astrophysics Data System (ADS)

    Yoon, Dong-Jin; Park, Philip; Jung, Juong-Chae; Lee, Seung-Seok

    2002-06-01

    This study was aimed at developing a new method for assessing the integrity of concrete structures. Especially acoustic emission technique was used in carrying out both laboratory experiment and field application. From the previous laboratory study, we confirmed that AE analysis provided a promising approach for estimating the level of damage and distress in concrete structures. The Felicity ratio, one of the key parameter for assessing damage, exhibits a favorable correlation with the overall damage level. The total number of AE events under stepwise cyclic loading also showed a good agreement with the damage level. In this study, a new suggested technique was applied to several concrete bridges in Korea in order to verify the applicability in field. The AE response was analyzed to obtain key parameters such as the total number and rate of AE events, AE parameter analysis for each event, and the characteristic features of the waveform as well as Felicity ratio analysis. Stepwise loading-unloading procedure for AE generation was introduced in field test by using each different weight of vehicle. According to the condition of bridge, for instance new or old bridge, AE event rate and AE generation behavior indicated many different aspects. The results showed that the suggested analyzing method would be a promising approach for assessing the integrity of concrete structures.

  14. Keys to Transition: The California Model.

    ERIC Educational Resources Information Center

    Kearly, Patt

    This publication addresses basic issues related to the concept of transition as it is applied to students with disabilities in California. Following a pretest (and its answer key), the document uses a question and answer format to discuss common concerns about transition, normalization, the school role, the "Bridges" model developed by…

  15. A Decision Support System for Concrete Bridge Maintenance

    NASA Astrophysics Data System (ADS)

    Rashidi, Maria; Lemass, Brett; Gibson, Peter

    2010-05-01

    The maintenance of bridges as a key element in transportation infrastructure has become a major concern for asset managers and society due to increasing traffic volumes, deterioration of existing bridges and well-publicised bridge failures. A pivotal responsibility for asset managers in charge of bridge remediation is to identify the risks and assess the consequences of remediation programs to ensure that the decisions are transparent and lead to the lowest predicted losses in recognized constraint areas. The ranking of bridge remediation treatments can be quantitatively assessed using a weighted constraint approach to structure the otherwise ill-structured phases of problem definition, conceptualization and embodiment [1]. This Decision Support System helps asset managers in making the best decision with regards to financial limitations and other dominant constraints imposed upon the problem at hand. The risk management framework in this paper deals with the development of a quantitative intelligent decision support system for bridge maintenance which has the ability to provide a source for consistent decisions through selecting appropriate remediation treatments based upon cost, service life, product durability/sustainability, client preferences, legal and environmental constraints. Model verification and validation through industry case studies is ongoing.

  16. Controlled Blasting for Deconstruction of a Railway Bridge Near Sahibganj

    NASA Astrophysics Data System (ADS)

    Mandal, S. K.; Ghosh, A. K.; Oraon, S.

    2018-06-01

    Some of the Indian Railway bridges require reconstruction for electrification and expansion of railway tracks. Dismantling of bridge within time schedule in densely populated area requires controlled and pre-planned blasting methodology for safe pulling down of the structure and quick removal of blasted debris for fast restoration of tracks and smooth plying of trains. The three arched railway bridge (Bridge No. 61) located between Sahibganj and Karamtola cases one such example where the bridge was dismantled and the track was restored within 4 h of blasting, though the stipulated block period for demolition and restoration of tracks was 6 h. The 25.48 m long three-arched bridge was drilled and blasted with 225 number of blastholes (32 mm diameter) and 100 kg explosive (25 mm diameter). Length of blastholes varied between 0.5 and 1.8 m with blast geometry of 0.3-0.35 m burden and 0.33 m spacing. This paper deals with the conceptual and theoretical model developed for identification of the key locations for drilling and implementation of the same. It also discusses about the precautionary measures and the drilling pattern adopted for quick demolition and speedy restoration of tracks.

  17. Controlled Blasting for Deconstruction of a Railway Bridge Near Sahibganj

    NASA Astrophysics Data System (ADS)

    Mandal, S. K.; Ghosh, A. K.; Oraon, S.

    2018-02-01

    Some of the Indian Railway bridges require reconstruction for electrification and expansion of railway tracks. Dismantling of bridge within time schedule in densely populated area requires controlled and pre-planned blasting methodology for safe pulling down of the structure and quick removal of blasted debris for fast restoration of tracks and smooth plying of trains. The three arched railway bridge (Bridge No. 61) located between Sahibganj and Karamtola cases one such example where the bridge was dismantled and the track was restored within 4 h of blasting, though the stipulated block period for demolition and restoration of tracks was 6 h. The 25.48 m long three-arched bridge was drilled and blasted with 225 number of blastholes (32 mm diameter) and 100 kg explosive (25 mm diameter). Length of blastholes varied between 0.5 and 1.8 m with blast geometry of 0.3-0.35 m burden and 0.33 m spacing. This paper deals with the conceptual and theoretical model developed for identification of the key locations for drilling and implementation of the same. It also discusses about the precautionary measures and the drilling pattern adopted for quick demolition and speedy restoration of tracks.

  18. Towards Large-Scale, Non-Destructive Inspection of Concrete Bridges

    NASA Astrophysics Data System (ADS)

    Mahmoud, A.; Shah, A. H.; Popplewell, N.

    2005-04-01

    It is estimated that the rehabilitation of deteriorating engineering infrastructure in the harsh North American environment could cost billions of dollars. Bridges are key infrastructure components for surface transportation. Steel-free and fibre-reinforced concrete is used increasingly nowadays to circumvent the vulnerability of steel rebar to corrosion. Existing steel-free and fibre-reinforced bridges may experience extensive surface-breaking cracks that need to be characterized without incurring further damage. In the present study, a method that uses Lamb elastic wave propagation to non-destructively characterize cracks in plain as well as fibre-reinforced concrete is investigated both numerically and experimentally. Numerical and experimental data are corroborated with good agreement.

  19. An effective means for damage detection of bridges using the contact-point response of a moving test vehicle

    NASA Astrophysics Data System (ADS)

    Zhang, Bin; Qian, Yao; Wu, Yuntian; Yang, Y. B.

    2018-04-01

    To further the technique of indirect measurement, the contact-point response of a moving test vehicle is adopted for the damage detection of bridges. First, the contact-point response of the vehicle moving over the bridge is derived both analytically and in central difference form (for field use). Then, the instantaneous amplitude squared (IAS) of the driving component of the contact-point response is calculated by the Hilbert transform, making use of its narrow-band feature. The IAS peaks serve as the key parameter for damage detection. In the numerical simulation, a damage (crack) is modeled by a hinge-spring unit. The feasibility of the proposed method to detect the location and severity of a damage or multi damages of the bridge is verified. Also, the effects of surface roughness, vehicle speed, measurement noise and random traffic are studied. In the presence of ongoing traffic, the damages of the bridge are identified from the repeated or invariant IAS peaks generated for different traffic flows by the same test vehicle over the bridge.

  20. Pegasus power system facility upgrades

    NASA Astrophysics Data System (ADS)

    Lewicki, B. T.; Kujak-Ford, B. A.; Winz, G. R.

    2008-11-01

    Two key Pegasus systems have been recently upgraded: the Ohmic-transformer IGCT bridge control system, and the plasma-gun injector power system. The Ohmic control system contains two new microprocessor controlled components to provide an interface between the PWM controller and the IGCT bridges. An interface board conditions the command signals from the PWM controller. A splitter/combiner board routes the conditioned PWM commands to an array of IGCT bridges and interprets IGCT bridge status. This system allows for any PWM controller to safely control IGCT bridges. Future developments will include a transition to a polyphasic bridge control. This will allow for 3 to 4 times the present pulse length and provide a much higher switching frequency. The plasma gun injector system now includes active current feedback control on gun bias current via PWM buck type power supplies. Near term goals include a doubling or tripling of the applied bias voltage. Future arc bias system power supplies may include a simpler boost type system which will allow access to even higher voltages using existing low voltage energy storage systems.

  1. Salt-Bridge Energetics in Halophilic Proteins

    PubMed Central

    Nayek, Arnab; Sen Gupta, Parth Sarthi; Banerjee, Shyamashree; Mondal, Buddhadev; Bandyopadhyay, Amal K.

    2014-01-01

    Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges) to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are −3.0 kcal mol−1. Majority (78%) of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46%) with a net contribution of −5.0 kcal mol−1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (−10 kcal mol−1) exceeds than that of bridge term (−7 kcal mol−1). Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic signature in its specific electrostatic interactions which we hope would help in protein engineering and bioinformatics studies. PMID:24743799

  2. Salt-bridge energetics in halophilic proteins.

    PubMed

    Nayek, Arnab; Sen Gupta, Parth Sarthi; Banerjee, Shyamashree; Mondal, Buddhadev; Bandyopadhyay, Amal K

    2014-01-01

    Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges) to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are -3.0 kcal mol-1. Majority (78%) of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46%) with a net contribution of -5.0 kcal mol-1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (-10 kcal mol-1) exceeds than that of bridge term (-7 kcal mol-1). Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic signature in its specific electrostatic interactions which we hope would help in protein engineering and bioinformatics studies.

  3. Bridging the Gap: Linking Simulation and Testing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Krajewski, Paul E.; Carsley, John; Stoudt, Mark R.

    2012-09-01

    The Materials Genome Initiative (MGI) which is a key enabler for the Advanced Manufacturing Partnership, announced in 2011 by U.S. President Barack Obama, was established to accelerate the development and deployment of advanced materials. The MGI is driven by the need to "bridge the gap" between (I) experimental results and computational analysis to enable the rapid development and validation of new mateirals, and (II) the processes required to convert these materials into useable goods.

  4. Research on construction technology for orthotropic steel deck pavement of Haihe River Chunyi Bridge

    NASA Astrophysics Data System (ADS)

    Xue, Y. C.; Qian, Z. D.; Zhang, M.

    2017-01-01

    In order to ensure the good service quality of orthotropic steel deck pavement of Haihe River Chunyi Bridge in Tianjin, and to reduce the occurrence of pavement diseases like lateral and longitudinal cracks, the key working procedures such as steel deck cleaning, anticorrosive coating, bonding layer spraying, seam cutting, epoxy asphalt concrete’s mixing, transportation, paving and compaction were studied. The study was based on the main features of epoxy asphalt concrete which is the pavement materials of Haihe River Chunyi Bridge, and combined with the basic characteristics and construction conditions of Haihe River Chunyi Bridge. Furthermore, some processing measures like controlling time and temperature, continuous paving with two pavers, lateral feeding, and improving the compaction method were proposed. The project example shows that the processing measures can effectively solve the technical difficulties in the construction of orthotropic steel deck pavement of Haihe River Chunyi Bridge, can greatly improve the construction speed and quality, and can provide reference for the same kinds of orthotropic steel deck pavement construction.

  5. Disulfide bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins.

    PubMed

    Cogliati, Clelia; Tomaselli, Simona; Assfalg, Michael; Pedò, Massimo; Ferranti, Pasquale; Zetta, Lucia; Molinari, Henriette; Ragona, Laura

    2009-10-01

    Bile acid-binding proteins (BABPs) are cytosolic lipid chaperones that play central roles in driving bile flow, as well as in the adaptation to various pathological conditions, contributing to the maintenance of bile acid homeostasis and functional distribution within the cell. Understanding the mode of binding of bile acids with their cytoplasmic transporters is a key issue in providing a model for the mechanism of their transfer from the cytoplasm to the nucleus, for delivery to nuclear receptors. A number of factors have been shown to modulate bile salt selectivity, stoichiometry, and affinity of binding to BABPs, e.g. chemistry of the ligand, protein plasticity and, possibly, the formation of disulfide bridges. Here, the effects of the presence of a naturally occurring disulfide bridge on liver BABP ligand-binding properties and backbone dynamics have been investigated by NMR. Interestingly, the disulfide bridge does not modify the protein-binding stoichiometry, but has a key role in modulating recognition at both sites, inducing site selectivity for glycocholic and glycochenodeoxycholic acid. Protein conformational changes following the introduction of a disulfide bridge are small and located around the inner binding site, whereas significant changes in backbone motions are observed for several residues distributed over the entire protein, both in the apo form and in the holo form. Site selectivity appears, therefore, to be dependent on protein mobility rather than being governed by steric factors. The detected properties further establish a parallelism with the behaviour of human ileal BABP, substantiating the proposal that BABPs have parallel functions in hepatocytes and enterocytes.

  6. Bridging medicine and biomedical technology: enhance translation of fundamental research to patient care

    PubMed Central

    Raff, Adam B.; Seiler, Theo G.; Apiou-Sbirlea, Gabriela

    2017-01-01

    The ‘Bridging medicine and biomedical technology’ special all-congress session took place for the first time at the OSA Biophotonics Congress: Optics in Life Sciences in 2017 (http://www.osa.org/enus/meetings/osa_meetings/optics_in_the_life_sciences/bridging_medicine_and_biomedical_technology_specia/). The purpose was to identify key challenges the biomedical scientists in academia have to overcome to translate their discoveries into clinical practice through robust collaborations with industry and discuss best practices to facilitate and accelerate the process. Our paper is intended to complement the session by providing a deeper insight into the concept behind the structure and the content we developed. PMID:29296473

  7. Bridge Condition Assessment Using D Numbers

    PubMed Central

    Hu, Yong

    2014-01-01

    Bridge condition assessment is a complex problem influenced by many factors. The uncertain environment increases more its complexity. Due to the uncertainty in the process of assessment, one of the key problems is the representation of assessment results. Though there exists many methods that can deal with uncertain information, however, they have more or less deficiencies. In this paper, a new representation of uncertain information, called D numbers, is presented. It extends the Dempster-Shafer theory. By using D numbers, a new method is developed for the bridge condition assessment. Compared to these existing methods, the proposed method is simpler and more effective. An illustrative case is given to show the effectiveness of the new method. PMID:24696639

  8. JANNAF 17th Propulsion Systems Hazards Subcommittee Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    Volume 1, the first of two volumes is a compilation of 16 unclassified/unlimited technical papers presented at the 17th meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Propulsion Systems Hazards Subcommittee (PSHS) held jointly with the 35th Combustion Subcommittee (CS) and Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7 - 11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include projectile and shaped charge jet impact vulnerability of munitions; thermal decomposition and cookoff behavior of energetic materials; damage and hot spot initiation mechanisms with energetic materials; detonation phenomena of solid energetic materials; and hazard classification, insensitive munitions, and propulsion systems safety.

  9. KSC-2014-2046

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Greg Clements, chief of Kennedy's Control and Data Systems Division and lead for the Engineering and Technology's Small Payload Integrated Testing Services, or SPLITS, line of business, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  10. KSC-2014-2047

    NASA Image and Video Library

    2014-04-11

    CAPE CANAVERAL, Fla. -- At the Marriott Courtyard Hotel in Cocoa Beach, Fla., Greg Clements, chief of Kennedy's Control and Data Systems Division and lead for the Engineering and Technology's Small Payload Integrated Testing Services, or SPLITS, line of business, speaks to participants in the 4th International Workshop on Lunar and Planetary Compact and Cryogenic Science and Technology Applications. Scientists, engineers and entrepreneurs interested in research on the moon and other planetary surfaces, recently participated in the Workshop. Taking place April 8-11, 2014, the event was designed to foster collaborative work among those interested in solving the challenges of building hardware, software and businesses interested in going back to the moon and exploring beyond. Photo credit: NASA/Daniel Casper

  11. Standardization of quality control plans for highway bridges in Europe: COST Action TU 1406

    NASA Astrophysics Data System (ADS)

    Casas, Joan R.; Matos, Jose Campos e.

    2017-09-01

    In Europe, as all over the world, the need to manage roadway bridges in an efficient way led to the development of different management systems. Hence, nowadays, many European countries have their own system. Although they present a similar architectural framework, several differences can be appointed. These differences constitute a divergent mechanism that may conduct to different decisions on maintenance actions. Within the roadway bridge management process, the identification of maintenance needs is more effective when developed in a uniform and repeatable manner. This process can be accomplished by the identification of performance indicators and definition of performance goals and key performance indicators (KPI), improving the planning of maintenance strategies. Therefore, a discussion at a European level, seeking to achieve a standardized approach in this subject, will bring significant benefits. Accordingly, a COST Action is under way in Europe with the aim of standardizing the establishment of quality control plans for roadway bridges.

  12. Improvement in Titanium Complexes Bearing Schiff Base Ligands in the Ring-Opening Polymerization of L-Lactide: A Dinuclear System with Hydrazine-Bridging Schiff Base Ligands.

    PubMed

    Tseng, Hsi-Ching; Chen, Hsing-Yin; Huang, Yen-Tzu; Lu, Wei-Yi; Chang, Yu-Lun; Chiang, Michael Y; Lai, Yi-Chun; Chen, Hsuan-Ying

    2016-02-15

    A series of titanium (Ti) complexes bearing hydrazine-bridging Schiff base ligands were synthesized and investigated as catalysts for the ring-opening polymerization (ROP) of L-lactide (LA). Complexes with electron withdrawing or steric bulky groups reduced the catalytic activity. In addition, the steric bulky substituent on the imine groups reduced the space around the Ti atom and then reduced LA coordination with Ti atom, thereby reducing catalytic activity. All the dinuclear Ti complexes exhibited higher catalytic activity (approximately 10-60-fold) than mononuclear L(Cl-H)-TiOPr2 did. The strategy of bridging dinuclear Ti complexes with isopropoxide groups in the ROP of LA was successful, and adjusting the crowded heptacoordinated transition state by the bridging isopropoxide groups may be the key to our successful strategy.

  13. The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells.

    PubMed

    Merabet, Samir; Ebner, Andreas; Affolter, Markus

    2005-08-01

    The stereotyped outgrowth of tubular branches of the Drosophila tracheal system is orchestrated by the local and highly dynamic expression profile of branchless (bnl), which encodes a secreted fibroblast growth factor (FGF)-like molecule. Despite the importance of the spatial and temporal bnl regulation, little is known about the upstream mechanisms that establish its complex expression pattern. Here, we show that the Extradenticle and Homothorax selector proteins control bnl transcription in a single cell per segment, the mesodermal bridge-cell. In addition, we observed that a key determinant of bridge-cell specification, the transcription factor Hunchback, is also required for bnl expression. Therefore, we propose that one of the functions of the bridge-cell is to synthesize and secrete the chemoattractant Bnl. These findings provide a hitherto unknown and interesting link between combinatorial inputs of transcription factors, cell-specific ligand expression and organ morphogenesis.

  14. CF60 Concrete Composition Design and Application on Fudiankou Xijiang Super Large Bridge

    NASA Astrophysics Data System (ADS)

    Qiu, Yi Mei; Wen, Sen Yuan; Chen, Jun Xiang

    2018-06-01

    Guangxi Wuzhou City Ring Road Fudiankou Xijiang super large bridge CF60 concrete is a new multi-phase composite high-performance concrete, this paper for the Fudiankou Xijiang bridge structure and characteristics of the project, in accordance with the principle of local materials and technical specification requirements, combined with the site conditions of CF60 engineering high performance concrete component materials, proportion and the technical performance, quantify the main physical and mechanical performance index. Analysis main influencing factors of the technical indicators, reasonable adjustment of concrete mix design parameters, and the use of technical means of admixture and multi-function composite admixture of concrete, obtain the optimal proportion of good work, process, mechanical properties stability and durability of engineering properties, recommend and verification of concrete mix; to explore the CF60 high performance concrete Soil in the Fudiankou Xijiang bridge application technology, detection and tracking the quality of concrete construction, concrete structure during the construction of the key technology and control points is proposed, evaluation of CF60 high performance concrete in the actual engineering application effect and benefit to ensure engineering quality of bridge structure and service life, and super long span bridge engineering construction to provide basis and reference.

  15. STABILITY OF BISEXUAL BEHAVIOR AND EXTENT OF VIRAL BRIDGING BEHAVIOR AMONG MEN WHO HAVE SEX WITH MEN AND WOMEN (MSMW)

    PubMed Central

    Friedman, M. Reuel; Stall, Ron; Plankey, Michael; Shoptaw, Steve; Herrick, A.L.; Surkan, Pamela J.; Teplin, Linda; Silvestre, Anthony J.

    2016-01-01

    BACKGROUND Bisexual men experience significant health disparities likely related to biphobia. Biphobia presents via several preconceptions, including that bisexuality is transitory, and that bisexual men act as viral bridges between MSM and heterosexual populations. We analyzed data from a prospective cohort of gay and bisexual men, the Multicenter AIDS Cohort Study, to test these preconceptions. METHODS Men reporting both male and female sexual partners (MSMW) between 2002—2009 (n=111) were classified as behaviorally bisexual. We assessed five hypotheses over two domains (transience of bisexual behavior and viral bridging). RESULTS Transience No evidence was found supporting transitory nature of bisexuality. Trajectories of bisexual behavior were not transient over time. Bridging We found little evidence to support substantial viral bridging behavior. Notably, HIV-positive MSMW reported lower proportions of female partners than HIV-negative MSMW. DISCUSSION Our results provide no empirical support for bisexual transience and scant support for viral bridging hypotheses. Our results provide key data showing that male bisexual behavior may be stable over long time periods, and that behaviorally bisexual men’s risk to female sexual partners may be lower than expected. PMID:27873033

  16. Systematic Review: Bridging the Gap in RPN-to-RN Transitions.

    PubMed

    Suva, Grace; Sager, Shelley; Mina, Elaine Santa; Sinclair, Nancy; Lloyd, Monique; Bajnok, Irmajean; Xiao, Sarah

    2015-07-01

    To review the evidence examining the influences of successful education and professional role transition for registered practical nurses (RPNs) pursuing a baccalaureate degree in nursing (BScN) and registered nurse (RN) licensure through RPN-to-RN bridging programs. Systematic review of papers published between 1995 and 2014 that evaluated students' education and professional role transitions from RPN to RN. Thirty-nine papers were selected that observed or studied the change or transition in designation from RPN to RN, or its equivalent, through bridging programs and analyzed thematically according to Meleis, Sawyer, Im, Hilfinger Messias, and Schumacher's transition model. Personal, community, and social conditions related to preparation for entry, program enrolment, and postgraduate clinical integration influence successful education and professional role transitions for RPN-to-RN bridging students. Providing key transition supports may enhance the potential for successful student transition into and throughout a bridging program, but further research is necessary to enhance this understanding and to recommend best practices for optimizing students' success. The evidence from this review identifies facilitators and barriers to successful education and professional role transition for RPN-to-RN bridging students, and identifies important considerations for future research. © 2015 Sigma Theta Tau International.

  17. Performance-based seismic assessment of skewed bridges with and without considering soil-foundation interaction effects for various site classes

    NASA Astrophysics Data System (ADS)

    Ghotbi, Abdoul R.

    2014-09-01

    The seismic behavior of skewed bridges has not been well studied compared to straight bridges. Skewed bridges have shown extensive damage, especially due to deck rotation, shear keys failure, abutment unseating and column-bent drift. This research, therefore, aims to study the behavior of skewed and straight highway overpass bridges both with and without taking into account the effects of Soil-Structure Interaction (SSI) due to near-fault ground motions. Due to several sources of uncertainty associated with the ground motions, soil and structure, a probabilistic approach is needed. Thus, a probabilistic methodology similar to the one developed by the Pacific Earthquake Engineering Research Center (PEER) has been utilized to assess the probability of damage due to various levels of shaking using appropriate intensity measures with minimum dispersions. The probabilistic analyses were performed for various bridge configurations and site conditions, including sand ranging from loose to dense and clay ranging from soft to stiff, in order to evaluate the effects. The results proved a considerable susceptibility of skewed bridges to deck rotation and shear keys displacement. It was also found that SSI had a decreasing effect on the damage probability for various demands compared to the fixed-base model without including SSI. However, deck rotation for all types of the soil and also abutment unseating for very loose sand and soft clay showed an increase in damage probability compared to the fixed-base model. The damage probability for various demands has also been found to decrease with an increase of soil strength for both sandy and clayey sites. With respect to the variations in the skew angle, an increase in skew angle has had an increasing effect on the amplitude of the seismic response for various demands. Deck rotation has been very sensitive to the increase in the skew angle; therefore, as the skew angle increased, the deck rotation responded accordingly. Furthermore, abutment unseating showed an increasing trend due to an increase in skew angle for both fixed-base and SSI models.

  18. Bryn Bridges and mutagenesis: exploring the intellectual space.

    PubMed

    Walker, G C

    2001-02-25

    The products of the SOS-regulated umuDC genes are required for most UV and chemical mutagenesis in Escherichia coli. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the umuDC gene products and the replicative DNA polymerase.

  19. Electron Transport Modeling of Molecular Nanoscale Bridges Used in Energy Conversion Schemes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dunietz, Barry D

    2016-08-09

    The goal of the research program is to reliably describe electron transport and transfer processes at the molecular level. Such insight is essential for improving molecular applications of solar and thermal energy conversion. We develop electronic structure models to study (1) photoinduced electron transfer and transport processes in organic semiconducting materials, and (2) charge and heat transport through molecular bridges. We seek fundamental understanding of key processes, which lead to design new experiments and ultimately to achieve systems with improved properties.

  20. McNamara, Clifford, and the Burdens of Vietnam, 1965-1969 (Secretaries of Defense Historical Series, Volume 6)

    DTIC Science & Technology

    2011-01-01

    North Vietnam’s line of communication ( LOC ) by destroying roads, railroads, and bridges. The Chiefs recommended that approval of later phases...Rolling Thunder to increase the cost of the war to the communists. Rolling Thunder 9, launched 2 April, inaugurated the LOC interdiction phase...destruction of three key bridges that created a LOC bottleneck. Indeed, battles with MIGs in North Vietnam’s skies and the prospect of heavy U.S

  1. The role of salt bridges on the temperature adaptation of aqualysin I, a thermostable subtilisin-like proteinase.

    PubMed

    Jónsdóttir, Lilja B; Ellertsson, Brynjar Ö; Invernizzi, Gaetano; Magnúsdóttir, Manuela; Thorbjarnardóttir, Sigríður H; Papaleo, Elena; Kristjánsson, Magnús M

    2014-12-01

    Differences in salt bridges are believed to be a structural hallmark of homologous enzymes from differently temperature-adapted organisms. Nevertheless, the role of salt bridges on structural stability is still controversial. While it is clear that most buried salt bridges can have a functional or structural role, the same cannot be firmly stated for ion pairs that are exposed on the protein surface. Salt bridges, found in X-ray structures, may not be stably formed in solution as a result of high flexibility or high desolvation penalty. More studies are thus needed to clarify the picture on salt bridges and temperature adaptation. We contribute here to this scenario by combining atomistic simulations and experimental mutagenesis of eight mutant variants of aqualysin I, a thermophilic subtilisin-like proteinase, in which the residues involved in salt bridges and not conserved in a psychrophilic homolog were systematically mutated. We evaluated the effects of those mutations on thermal stability and on the kinetic parameters. Overall, we show here that only few key charged residues involved in salt bridges really contribute to the enzyme thermal stability. This is especially true when they are organized in networks, as here attested by the D17N mutation, which has the most remarkable effect on stability. Other mutations had smaller effects on the properties of the enzyme indicating that most of the isolated salt bridges are not a distinctive trait related to the enhanced thermal stability of the thermophilic subtilase. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Nanoink bridge-induced capillary pen printing for chemical sensors.

    PubMed

    Kahng, Seong-Joong; Cerwyn, Chiew; Dincau, Brian M; Kim, Jong-Hoon; Novosselov, Igor V; Anantram, M P; Chung, Jae-Hyun

    2018-08-17

    Single-walled carbon nanotubes (SWCNTs) are used as a key component for chemical sensors. For miniature scale design, a continuous printing method is preferred for electrical conductance without damaging the substrate. In this paper, a non-contact capillary pen printing method is presented by the formation of a nanoink bridge between the nib of a capillary pen and a polyethylene terephthalate film. A critical parameter for stable printing is the advancing contact angle at the bridge meniscus, which is a function of substrate temperature and printing speed. The printed pattern including dots, lines, and films of SWCNTs are characterized by morphology, optical transparency, and electrical properties. Gas and pH sensors fabricated using the non-contact printing method are demonstrated as applications.

  3. Social capital among migrating doctors: the "bridge" over troubled water.

    PubMed

    Terry, Daniel R; Quynh, Lê

    2014-01-01

    The purpose of this paper is to examine the concept of social capital among International Medical Graduates (IMGs). It will specifically examine bridging social capital and greater intercultural communication which provides IMGs access to the wider community and plays a key role in cross-cultural adaptation and acculturation. A review of the literature. An Australian wide shortage of doctors has led to an increased reliance on the recruitment of IMGs. As IMGs migrate, they may encounter different meanings of illness, models of care and a number of social challenges. Nevertheless, greater cross-cultural adaptation and acculturation occurs through bridging social capital, where intercultural communication, new social networks and identity aids integration. This process produces more opportunities for economic capital growth and upward mobility than bonding social capital. Concerns regarding immigration, appropriate support and on-going examination processes have been expressed by IMGs in a number of studies and policy papers. However, there is very little insight into what contributes cross-cultural adaptation of IMGs. As IMGs migrate to not only a new country, but also a new health system and workplace they arrive with different cultural meanings of illness and models of care. These differences may be in contrast to the dominant western medical model, but often bring positive contributions to patient care in the new environment. In addition, improving bridging social capital provides IMGs access to the wider community and has been demonstrated to play a key role in cross-cultural adaptation and ultimately acculturation.

  4. Transportation and the Bureau of Land Management

    DOT National Transportation Integrated Search

    2008-01-01

    The Volpe Center prepared a promotional booklet featuring an overview of the BLM's transportation infrastructure. The booklet describes the BLM's roads, bridges, and trails; highlights their economic and recreational importance; and lists key transpo...

  5. Bridging the Scientific and Indigenous Communities to Study Sea Ice Change in Arctic Alaska

    NASA Astrophysics Data System (ADS)

    Mahoney, A. R.; Zappa, C. J.; Betcher, S. R.; Hauser, D.; Whiting, A.; Goodwin, J.; Harris, C.; Schaefer, B.; Schaefer, R.

    2017-12-01

    Ikaavik Sikukuun (Ice Bridges) is a newly-launched research partnership in Kotzebue, Alaska, that adopts an end-to-end community-based approach to study fundamental processes underlying the mechanisms and impacts of the changing sea ice in coastal Alaska. Under guidance from a local advisory council, we will use state-of-the-art observing techniques including long-range unmanned aerial systems (UAS) to study under-observed sea ice regions during critical periods of marine mammal migration, molting and reproduction. Here, we describe what, to the best of our knowledge, is a precedent-setting approach to co-creating research questions and hypotheses that integrate indigenous knowledge (IK) and interdisciplinary scientific methods. A key element of this approach is that we established an advisory committee of local IK holders before defining specific research questions. This has enabled us to iteratively develop hypotheses that incorporate IK and respond to the research needs of the local community while also addressing key geophysical and ecological questions related to changes in the seasonal ice zone. The advisory committee will be key participants in the project team, ensuring that IK is incorporated into the design of the observing plan and the synthesis and dissemination of findings. In addition to building bridges between the scientific community and indigenous residents of Kotzebue, the legacy of our project will include a video documentary that will allow us to share the story of this partnership and our findings with a broad audience.

  6. An O([Formula: see text]) algorithm for sorting signed genomes by reversals, transpositions, transreversals and block-interchanges.

    PubMed

    Yu, Shuzhi; Hao, Fanchang; Leong, Hon Wai

    2016-02-01

    We consider the problem of sorting signed permutations by reversals, transpositions, transreversals, and block-interchanges. The problem arises in the study of species evolution via large-scale genome rearrangement operations. Recently, Hao et al. gave a 2-approximation scheme called genome sorting by bridges (GSB) for solving this problem. Their result extended and unified the results of (i) He and Chen - a 2-approximation algorithm allowing reversals, transpositions, and block-interchanges (by also allowing transversals) and (ii) Hartman and Sharan - a 1.5-approximation algorithm allowing reversals, transpositions, and transversals (by also allowing block-interchanges). The GSB result is based on introduction of three bridge structures in the breakpoint graph, the L-bridge, T-bridge, and X-bridge that models goodreversal, transposition/transreversal, and block-interchange, respectively. However, the paper by Hao et al. focused on proving the 2-approximation GSB scheme and only mention a straightforward [Formula: see text] algorithm. In this paper, we give an [Formula: see text] algorithm for implementing the GSB scheme. The key idea behind our faster GSB algorithm is to represent cycles in the breakpoint graph by their canonical sequences, which greatly simplifies the search for these bridge structures. We also give some comparison results (running time and computed distances) against the original GSB implementation.

  7. A probabilistic bridge safety evaluation against floods.

    PubMed

    Liao, Kuo-Wei; Muto, Yasunori; Chen, Wei-Lun; Wu, Bang-Ho

    2016-01-01

    To further capture the influences of uncertain factors on river bridge safety evaluation, a probabilistic approach is adopted. Because this is a systematic and nonlinear problem, MPP-based reliability analyses are not suitable. A sampling approach such as a Monte Carlo simulation (MCS) or importance sampling is often adopted. To enhance the efficiency of the sampling approach, this study utilizes Bayesian least squares support vector machines to construct a response surface followed by an MCS, providing a more precise safety index. Although there are several factors impacting the flood-resistant reliability of a bridge, previous experiences and studies show that the reliability of the bridge itself plays a key role. Thus, the goal of this study is to analyze the system reliability of a selected bridge that includes five limit states. The random variables considered here include the water surface elevation, water velocity, local scour depth, soil property and wind load. Because the first three variables are deeply affected by river hydraulics, a probabilistic HEC-RAS-based simulation is performed to capture the uncertainties in those random variables. The accuracy and variation of our solutions are confirmed by a direct MCS to ensure the applicability of the proposed approach. The results of a numerical example indicate that the proposed approach can efficiently provide an accurate bridge safety evaluation and maintain satisfactory variation.

  8. Additive Manufacturing a Liquid Hydrogen Rocket Engine

    NASA Technical Reports Server (NTRS)

    Jones, Carl P.; Robertson, Elizabeth H.; Koelbl, Mary Beth; Singer, Chris

    2016-01-01

    Space Propulsion is a 5 day event being held from 2nd May to the 6th May 2016 at the Rome Marriott Park Hotel in Rome, Italy. This event showcases products like Propulsion sub-systems and components, Production and manufacturing issues, Liquid, Solid, Hybrid and Air-breathing Propulsion Systems for Launcher and Upper Stages, Overview of current programmes, AIV issues and tools, Flight testing and experience, Technology building blocks for Future Space Transportation Propulsion Systems : Launchers, Exploration platforms & Space Tourism, Green Propulsion for Space Transportation, New propellants, Rocket propulsion & global environment, Cost related aspects of Space Transportation propulsion, Modelling, Pressure-Thrust oscillations issues, Impact of new requirements and regulations on design etc. in the Automotive, Manufacturing, Fabrication, Repair & Maintenance industries.

  9. JANNAF 35th Combustion Subcommittee Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    Volume 1, the first of two volumes is a compilation of 63 unclassified/unlimited distribution technical papers presented at the 35th meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Combustion Subcommittee (CS) held jointly with the 17th Propulsion Systems Hazards Subcommittee (PSHS) and Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7-11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include solid gun propellant processing, ignition and combustion, charge concepts, barrel erosion and flash, gun interior ballistics, kinetics and molecular modeling, ETC gun modeling, simulation and diagnostics, and liquid gun propellant combustion; solid rocket motor propellant combustion, combustion instability fundamentals, motor instability, and measurement techniques; and liquid and hybrid rocket combustion.

  10. Bridging knowledge, policies and practices across the ageing and disability fields: a protocol for a scoping review to inform the development of a taxonomy.

    PubMed

    Nalder, Emily Joan; Putnam, Michelle; Salvador-Carulla, Luis; Spindel, Andria; Batliwalla, Zinnia; Lenton, Erica

    2017-10-25

    Bridging is a term used to describe activities, or tasks, used to promote collaboration and knowledge exchange across fields. This paper reports the protocol for a scoping review which aims to identify and characterise peer reviewed evidence describing bridging activities, between the ageing and disability fields. The purpose is to clarify the concepts underpinning bridging to inform the development of a taxonomy, and identify research strengths and gaps. A scoping review will be conducted. We will search Medline, Cumulative Index to Nursing and Allied Health Literature, Embase, PsycInfo, Sociological Abstracts and the Cochrane Library, to identify peer reviewed publications (reviews, experimental, observational, qualitative designs and expert commentaries) describing bridging activities. Grey literature, and articles not published in English will be excluded. Two investigators will independently complete article selection and data abstraction to minimise bias. A data extraction form will be iteratively developed and information from each publication will be extracted: (1) bibliographic, (2) methodological, (3) demographic, and (4) bridging information. Qualitative content analysis will be used to describe key concepts related to bridging. To our knowledge, this will be the first scoping review to describe bridging of ageing and disability knowledge, services and policies. The findings will inform the development of a taxonomy to define models of bridging that can be implemented and further evaluated to enable integrated care and improve systems and services for those ageing with disability. Ethics is not required because this is a scoping review of published literature. Findings will be disseminated through stakeholder meetings, conference presentations and peer reviewed publication. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Flood Early Warning in Bridge Management System: from idea to implementation

    NASA Astrophysics Data System (ADS)

    Kerin, Igor; Bekić, Damir; Michalis, Panagiotis; Šolman, Hrvoje; Cahill, Paul; Gilja, Gordon; Pakrashi, Vikram; Lapthorne, John; McKeogh, Eamon

    2017-04-01

    Recent advances in computational speed, cloud systems and GPRS data are some of the factors that have resulted in an increased number of operational and fully automatized Flood Early Warning Systems (FEWS). Flood forecasting is becoming a well-recognised solution for flood management as an indirect measure for minimising the risk should preventive or defence measures prove ineffective or are not feasible for implementation. Public acceptance of FEWS as a standalone solution is still considered to be at low level. Further public engagement regarding engineering risks and providing timely notifications and warnings can, however, establish the true value of such a system to the society in general. Flood risks can be direct, resulting in damage to buildings, infrastructure and natural resources, or indirect, which can be related to disaster losses leading to declines in commercial output or revenue and impact on wellbeing of people, typically from disruptions to the flow of goods and services. Flood risk and structural risks are closely related, thereby impacting the maintenance and management of bridges assets over watercourses. Many studies indicate that most bridge collapses are related to hydraulic effects and consequently scour issues (i.e. the removal of riverbed around bridge foundations due to flowing water). Consequently, hydraulic, hydrologic and geotechnical expertise and knowledge can lead to introducing FEWS as a key tool for Bridge Scour Management System (BSMS), forming a part of a BMS. The implementation of this concept was initiated with the EU/FP7 funded project BRIDGE SMS. The project introduces BSMS into the overall BMS to develop a reliable decision support tool which would efficiently manage bridge failure risks in a cost-effective way. This is accomplished through the development of FEWS, alongside monitoring systems that can provide important information about environmental and structural conditions at the catchment area and bridge site respectively. The recorded rainfall from instrumentation deployed over a catchment is used as input data for hydrological modelling and now-casting, which results in flow hydrographs at the bridge containing flow rates and water level information. Soil moisture data is also used to determine the appropriate hydrological model set-up, such as dry, medium or saturated catchment conditions. The output from the hydrological model is a now-cast flow hydrograph, with a lag time of up to 24 hours. Discharge hydrograph is correlated to water levels using an existing rating curve and to the flow velocity using discharge-flow velocity curve. Water levels and flow rates are correlated to the flow velocity which provide the basis for the prediction of scour depth. FEWS in BMS introduces readiness for extreme flood events, pointing out key indicators prior to an event. Also, by considering climate change effects which is resulting in more extreme weather phenomena's, FEWS provides important information about bridge safety and assists to coordinate resources in an efficient and cost-effective way. Acknowledgement The authors wish to acknowledge the financial support of the European Commission, through the Marie-Curie Industry-Academia Partnership and Pathways Network BRIDGE SMS (Intelligent Bridge Assessment Maintenance and Management System) - FP7-People-2013-IAPP- 612517.

  12. Studies of ZVS soft switching of dual-active-bridge isolated bidirectional DC-DC converters

    NASA Astrophysics Data System (ADS)

    Xu, Fei; Zhao, Feng; Shi, Qibiao; Wen, Xuhui

    2018-05-01

    To operate dual-active-bridge isolated bidirectional dc- dc converter (DAB) at high efficiency, the two bridge switches must operate with Zero-Voltage-Switching (ZVS) over as wide an operating range as possible. This paper proposes a new perspective on realizing ZVS in dead-time. An exact theoretical analysis and mathematical mode is built to explain the process of ZVS switching in dead-time under Single Phase Shift (SPS) control strategy. In order to assure the two bridge switches operate on soft switching, every SPS switching point is analyzed. Generally, dead-time will be determined when the power electronic devices is selected. The key factor to realizing ZVS is the size of the end time of resonance comparing to dead-time. Through detailed analysis, it can obtain the conditions of all switches achieving ZVS turn-on and turn-off. Finally, simulation validates the theoretical analysis and some advice are given to realize the ZVS soft switching.

  13. Design and fabrication of single-crystal GaN nano-bridge on homogeneous substrate for nanoindentation

    NASA Astrophysics Data System (ADS)

    Hung, Shang-Chao

    2014-12-01

    This study reports a simple method to design and fabricate a freestanding GaN nano-bridge over a homogeneous short column as supporting leg. Test samples were fabricated from MOCVD-grown single-crystal GaN films over sapphire substrate using a FIB milling to leave freestanding short spans. We also investigated the nanoindentation characteristics and the corresponding nanoscopic mechanism of the GaN nano-bridge and its short column with a conical indenter inside transmission electron microscopy. The stress-strain mechanical properties and Young's modulus have also been examined and calculated as 108 GPa ± 4.8 % by the strain energy method. The significant slope switch of the L- D curve corresponds to the transition from the single-point bending indentation to the surface stretching indentation and has been interpreted with the evolution of TEM images. This freestanding fabrication and test have key advantages to characterize nanoscale behavior of one-dimensional bridge structure and greater ease of sample preparation over other micro-fabrication techniques.

  14. An impedance-based approach for detection and quantification of damage in cracked plates and loose bolts in bridge structures

    NASA Astrophysics Data System (ADS)

    Rabiei, Masoud; Sheldon, Jeremy; Palmer, Carl

    2012-04-01

    The applicability of Electro-Mechanical Impedance (EMI) approach to damage detection, localization and quantification in a mobile bridge structure is investigated in this paper. The developments in this paper focus on assessing the health of Armored Vehicle Launched Bridges (AVLBs). Specifically, two key failure mechanisms of the AVLB to be monitored were fatigue crack growth and damaged (loose) rivets (bolts) were identified. It was shown through experiment that bolt damage (defined here as different torque levels applied to bolts) can be detected, quantified and located using a network of lead zirconate titanate (PZT) transducers distributed on the structure. It was also shown that cracks of various sizes can be detected and quantified using the EMI approach. The experiments were performed on smaller laboratory specimens as well as full size bridge-like components that were built as part of this research. The effects of various parameters such as transducer type and size on the performance of the proposed health assessment approach were also investigated.

  15. The bridge permeameter; An alternative method for single-phase, steady-state permeability measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Graf, D.C.; Warpinski, N.R.

    Laboratory measurements of single-phase, steady-state permeability of porous rock are important for a number of different applications. The oil and gas industry uses permeability data as a key indicator of the producability of a hydrocarbon reservoir; effective containment of large volumes of oil in underground salt caverns is directly dependent upon the permeability of the adjacent cavern walls; and safe, long term underground isolation of radioactive and hazardous waste is contingent upon the flow and transport characteristics of the surrounding geologic formations. An alternative method for measuring single-phase, steady-state permeability of porous rock is presented. The use of troublesome andmore » expensive mass flow meters is eliminated and replaced with a bridge configuration of flow resistors. Permeability values can be determined directly from differential pressures across the bridge network, resulting in potentially significant cost savings and simplification for conducting these types of measurements. Results from the bridge permeameter are compared with results obtained using conventional methods.« less

  16. The missing links between planning and budgeting. Keys to survival in an era of entrepreneurialism.

    PubMed

    Rice, J A; Garside, P M

    1984-03-01

    For hospitals to survive the challenges of their turbulent environment, they must build stronger links between their planning and budgeting processes. Hospitals have traditionally experienced a gap between their long-range plans and short-range budgets. This article examines the scope, nature, and causes of this gap; clarifies the need to bridge this gap; and then discusses three major initiatives (missing links) to bridge the gap. Implications of these missing links for the hospital's board, physicians, managers, and systems are also described.

  17. A Battalion Staff Prepared for War: The Key to Combined Arms Success on the Modern Tactical Battlefield,

    DTIC Science & Technology

    1988-03-10

    comoat sunort Droblems put the 3d Battalion in a Drecarious Dosition On 4 November. First, the Kall River trail, the major route from the division to...was to maintain one- way traffic through to the Kall River bridge while Company A did the same from the bridge to Schmidt. C Company, in reserve...supply weasels from the 3d Battalion crossed the Kall . (52) Meanwhile, in Schmidt the 3d Battalion prepared to defend. * The battalion had no combined arms

  18. A sustainable dietetics bridging program: development and implementation in Atlantic Canada.

    PubMed

    Lordly, Daphne; Guy, Jennifer; Barry, Paula; Garus, Jennifer

    2014-01-01

    A provincial focus on immigration and improved foreign credential recognition has led to an investigation of best practices and subsequent recommendations for the development and implementation of a sustainable university-based bridging program for internationally educated dietitians in Atlantic Canada. Data were collected from various sources and used to inform program decisions and direction. An advisory framework was established through a core group representing dietetics education and regulation and internationalization. Subsequently, a key stakeholder group was formed. As a result of this collaboration and research, a dietetics bridging framework was developed and a program pilot tested. Lessons learned may inform similar endeavours and highlight the importance of collaborative leadership and collaboration among multiple stakeholders, and of creatively addressing program sustainability issues while keeping learners (internationally educated dietitians) at the centre.

  19. Stability of Bisexual Behavior and Extent of Viral Bridging Behavior Among Men Who Have Sex with Men and Women.

    PubMed

    Friedman, M Reuel; Stall, Ron; Plankey, Michael; Shoptaw, Steve; Herrick, A L; Surkan, Pamela J; Teplin, Linda; Silvestre, Anthony J

    2017-05-01

    Bisexual men experience significant health disparities likely related to biphobia. Biphobia presents via several preconceptions, including that bisexuality is transitory, and that bisexual men act as viral bridges between men who have sex with men and heterosexual populations. We analyzed data from a prospective cohort of gay and bisexual men, the Multicenter AIDS Cohort Study, to test these preconceptions. Men reporting both male and female sexual partners (MSMW) between 2002 and 2009 (n = 111) were classified as behaviorally bisexual. We assessed five hypotheses over two domains (transience of bisexual behavior and viral bridging). No evidence was found supporting the transitory nature of bisexuality. Trajectories of bisexual behavior were not transient over time. We found little evidence to support substantial viral bridging behavior. Notably, HIV-positive MSMW reported lower proportions of female partners than HIV-negative MSMW. Our results provide no empirical support for bisexual transience and scant support for viral bridging hypotheses. Our results provide key data showing that male bisexual behavior may be stable over long time periods and that behaviorally bisexual men's risk to female sexual partners may be lower than expected.

  20. Toughening by crack bridging in heterogeneous ceramics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Curtin, W.A.

    1995-05-01

    The toughening of a ceramic by crack bridging is considered, including the heterogeneity caused simply by spatial randomness in the bridge locations. The growth of a single planar crack is investigated numerically by representing the microstructure as an array of discrete springs with heterogeneity in the mechanical properties of each spring. The stresses on each microstructural element are determined, for arbitrary configurations of spring properties and heterogeneity, using a lattice Green function technique. For toughening by (heterogeneous) crack bridging for both elastic and Dugdale bridging mechanisms, the following key physical results are found: (1) growing cracks avoid regions which aremore » efficiently bridged, and do not propagate as self-similar penny cracks; (2) crack growth thus proceeds at lower applied stresses in a heterogeneous material than in an ordered material; (3) very little toughening is evident for moderate amounts of crack growth in many cases; and (4) a different R-curve is found for every particular spatial distribution of bridging elements. These results show that material reliability is determined by both the flaw distribution and the ``toughness`` distribution, or local environment, around each flaw. These results also demonstrate that the ``microstructural`` parameters derived from fitting an R-curve to a continuum model may not have an immediate relationship to the actual microstructure; the parameters are ``effective`` parameters that absorb the effects of the heterogeneity. The conceptual issues illuminated by these conclusions must be fully understood and appreciated to further develop microstructure-property relationships in ceramic materials.« less

  1. Superhydrophobic engineered cementitious composites for highway applications : phase I.

    DOT National Transportation Integrated Search

    2013-05-01

    The strength and durability of highway bridges are two of the key components in maintaining a high level of freight transportation capacity on the nations highways. This research focused on developing new hybrid superhydrophobic engineered cementi...

  2. Identifying and characterizing key nodes among communities based on electrical-circuit networks.

    PubMed

    Zhu, Fenghui; Wang, Wenxu; Di, Zengru; Fan, Ying

    2014-01-01

    Complex networks with community structures are ubiquitous in the real world. Despite many approaches developed for detecting communities, we continue to lack tools for identifying overlapping and bridging nodes that play crucial roles in the interactions and communications among communities in complex networks. Here we develop an algorithm based on the local flow conservation to effectively and efficiently identify and distinguish the two types of nodes. Our method is applicable in both undirected and directed networks without a priori knowledge of the community structure. Our method bypasses the extremely challenging problem of partitioning communities in the presence of overlapping nodes that may belong to multiple communities. Due to the fact that overlapping and bridging nodes are of paramount importance in maintaining the function of many social and biological networks, our tools open new avenues towards understanding and controlling real complex networks with communities accompanied with the key nodes.

  3. Physics validation for design change of KSTAR passive stabilizer

    NASA Astrophysics Data System (ADS)

    Jeon, Y. M.; Kim, J. Y.; Oh, Y. K.; Yang, H. L.; Kim, W. C.; Kim, H. K.; Sabbagh, S. A.; Bialek, J. M.; Humphreys, D. A.; Welander, A. S.; Walker, M. L.

    2009-11-01

    Recently, the design of the passive stabilizer in KSTAR has been changed to improve controllability of the active control system and reduce the possibility of producing an additional error field. Originally the passive stabilizer in KSTAR was designed for RWM and vertical instability (or VDE) stabilizations and plasma startup efficiency, so that current bridges were designed and combined through 3D saddle-loop connections. Since the key design change is removing the current bridges, it's essential to assure satisfactory control performance for these instabilities under the design change. Control capability for n=1 RWM and achievable βN will be addressed as a primary goal of the passive stabilizer together with vertical instability control and effects on plasma startup. In addition, the changes in electro-magnetic force on conducting structures will be discussed qualitatively as a key engineering issue of the design change.

  4. KSC-97PC1281

    NASA Image and Video Library

    1997-08-22

    KENNEDY SPACE CENTER, FLA. -- Following the presentation of the Universal Signal Conditioning Amplifier (USCA), a new piece of technology developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr., key participants in the partnership pose for a group portrait. They are (from left) Bill Larson, NASA; Dr. Pedro Medelius, INET; Roy Bridges, Jr., KSC Director; Ed Gladney and William Saputo, L-3 Communications; Pam Gillespi, representing Congressman Dave Weldon; and Frank Kinney, Technological Research and Development Authority. The USCA is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets

  5. Mechanical Properties of Respiratory Muscles

    PubMed Central

    Sieck, Gary C.; Ferreira, Leonardo F.; Reid, Michael B.; Mantilla, Carlos B.

    2014-01-01

    Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of the upper airway. The basic structural and functional properties of respiratory muscles are similar to those of other striated muscles (both skeletal and cardiac). The sarcomere is the fundamental organizational unit of striated muscles and sarcomeric proteins underlie the passive and active mechanical properties of muscle fibers. In this respect, the functional categorization of different fiber types provides a conceptual framework to understand the physiological properties of respiratory muscles. Within the sarcomere, the interaction between the thick and thin filaments at the level of cross-bridges provides the elementary unit of force generation and contraction. Key to an understanding of the unique functional differences across muscle fiber types are differences in cross-bridge recruitment and cycling that relate to the expression of different myosin heavy chain isoforms in the thick filament. The active mechanical properties of muscle fibers are characterized by the relationship between myoplasmic Ca2+ and cross-bridge recruitment, force generation and sarcomere length (also cross-bridge recruitment), external load and shortening velocity (cross-bridge cycling rate), and cross-bridge cycling rate and ATP consumption. Passive mechanical properties are also important reflecting viscoelastic elements within sarcomeres as well as the extracellular matrix. Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes, but their manifestations will depend on their impact on these basic elemental structures. PMID:24265238

  6. 00pp0065

    NASA Image and Video Library

    2000-01-14

    Before the start of the First Florida Space Summit, participants gather around the poster. From left are Center Director Roy Bridges, Representative Jim Davis, Representative Dave Weldon, NASA Administrator Dan Goldin, Senator Connie Mack, Governor Jeb Bush, Senator Bob Graham and 45th Space Wing Commander Brig. Gen. Donald Pettit. The summit, which was held at the Kennedy Space Center Visitor Complex, featured key state officials and aerospace companies to discuss the future of space as it relates to the State of Florida. Moderated by Bridges, the event also included State Senator Patsy Kurth, State Senator Charlie Bronson, and State Representative Randy Ball

  7. KSC-00pp0065

    NASA Image and Video Library

    2000-01-14

    Before the start of the First Florida Space Summit, participants gather around the poster. From left are Center Director Roy Bridges, Representative Jim Davis, Representative Dave Weldon, NASA Administrator Dan Goldin, Senator Connie Mack, Governor Jeb Bush, Senator Bob Graham and 45th Space Wing Commander Brig. Gen. Donald Pettit. The summit, which was held at the Kennedy Space Center Visitor Complex, featured key state officials and aerospace companies to discuss the future of space as it relates to the State of Florida. Moderated by Bridges, the event also included State Senator Patsy Kurth, State Senator Charlie Bronson, and State Representative Randy Ball

  8. Development of desiccant based air conditioning for hotels and motels. Final report, phase 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Banks, N.J.

    1994-10-01

    This report contains final reports from two phases of field tests: Phase I at the Marriott Courtyard in West Palm Beach, completed in October 1991, and Phase II at the Walt Disney World Swan Hotel in Orlando, completed in August 1993. The goal was to measure the performance and reliability of the desiccant units. The successfull program proved the value of the gas-fired desiccant technology to the hospitality industry. The desiccant units reduced moisture by 15 to 20% relative humidity. Measurements of temperature, humidity, and wallboard moisture content showed a dramatic reduction in the humidity levels experienced prior to installationmore » of the units and in the control areas without desiccants. Moisture damage was kept in check and remodelling due to it was eliminated.« less

  9. Transactions of the Twenty-First Water Reactor Safety Information Meeting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Monteleone, S.

    1993-10-01

    This report contains summaries of papers on reactor safety research to be presented at the 21st Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 25--27, 1993. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the Electric Power Research Institute (EPRI), the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningfulmore » discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session.« less

  10. Superhydrophobic engineered cementitious composites for highway applications : phase II.

    DOT National Transportation Integrated Search

    2013-06-01

    The strength and durability of highway bridges are two of the key components in maintaining a : high level of freight transportation capacity on the nations highways. : The CFIRE project 04-09 demonstrated the feasibility of a new hybrid engineered...

  11. BRIDG: a domain information model for translational and clinical protocol-driven research.

    PubMed

    Becnel, Lauren B; Hastak, Smita; Ver Hoef, Wendy; Milius, Robert P; Slack, MaryAnn; Wold, Diane; Glickman, Michael L; Brodsky, Boris; Jaffe, Charles; Kush, Rebecca; Helton, Edward

    2017-09-01

    It is critical to integrate and analyze data from biological, translational, and clinical studies with data from health systems; however, electronic artifacts are stored in thousands of disparate systems that are often unable to readily exchange data. To facilitate meaningful data exchange, a model that presents a common understanding of biomedical research concepts and their relationships with health care semantics is required. The Biomedical Research Integrated Domain Group (BRIDG) domain information model fulfills this need. Software systems created from BRIDG have shared meaning "baked in," enabling interoperability among disparate systems. For nearly 10 years, the Clinical Data Standards Interchange Consortium, the National Cancer Institute, the US Food and Drug Administration, and Health Level 7 International have been key stakeholders in developing BRIDG. BRIDG is an open-source Unified Modeling Language-class model developed through use cases and harmonization with other models. With its 4+ releases, BRIDG includes clinical and now translational research concepts in its Common, Protocol Representation, Study Conduct, Adverse Events, Regulatory, Statistical Analysis, Experiment, Biospecimen, and Molecular Biology subdomains. The model is a Clinical Data Standards Interchange Consortium, Health Level 7 International, and International Standards Organization standard that has been utilized in national and international standards-based software development projects. It will continue to mature and evolve in the areas of clinical imaging, pathology, ontology, and vocabulary support. BRIDG 4.1.1 and prior releases are freely available at https://bridgmodel.nci.nih.gov . © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  12. Bridge damage detection using spatiotemporal patterns extracted from dense sensor network

    NASA Astrophysics Data System (ADS)

    Liu, Chao; Gong, Yongqiang; Laflamme, Simon; Phares, Brent; Sarkar, Soumik

    2017-01-01

    The alarmingly degrading state of transportation infrastructures combined with their key societal and economic importance calls for automatic condition assessment methods to facilitate smart management of maintenance and repairs. With the advent of ubiquitous sensing and communication capabilities, scalable data-driven approaches is of great interest, as it can utilize large volume of streaming data without requiring detailed physical models that can be inaccurate and computationally expensive to run. Properly designed, a data-driven methodology could enable fast and automatic evaluation of infrastructures, discovery of causal dependencies among various sub-system dynamic responses, and decision making with uncertainties and lack of labeled data. In this work, a spatiotemporal pattern network (STPN) strategy built on symbolic dynamic filtering (SDF) is proposed to explore spatiotemporal behaviors in a bridge network. Data from strain gauges installed on two bridges are generated using finite element simulation for three types of sensor networks from a density perspective (dense, nominal, sparse). Causal relationships among spatially distributed strain data streams are extracted and analyzed for vehicle identification and detection, and for localization of structural degradation in bridges. Multiple case studies show significant capabilities of the proposed approach in: (i) capturing spatiotemporal features to discover causality between bridges (geographically close), (ii) robustness to noise in data for feature extraction, (iii) detecting and localizing damage via comparison of bridge responses to similar vehicle loads, and (iv) implementing real-time health monitoring and decision making work flow for bridge networks. Also, the results demonstrate increased sensitivity in detecting damages and higher reliability in quantifying the damage level with increase in sensor network density.

  13. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle

    PubMed Central

    Perz-Edwards, Robert J.; Irving, Thomas C.; Baumann, Bruce A. J.; Gore, David; Hutchinson, Daniel C.; Kržič, Uroš; Porter, Rebecca L.; Ward, Andrew B.; Reedy, Michael K.

    2011-01-01

    Stretch activation is important in the mechanical properties of vertebrate cardiac muscle and essential to the flight muscles of most insects. Despite decades of investigation, the underlying molecular mechanism of stretch activation is unknown. We investigated the role of recently observed connections between myosin and troponin, called “troponin bridges,” by analyzing real-time X-ray diffraction “movies” from sinusoidally stretch-activated Lethocerus muscles. Observed changes in X-ray reflections arising from myosin heads, actin filaments, troponin, and tropomyosin were consistent with the hypothesis that troponin bridges are the key agent of mechanical signal transduction. The time-resolved sequence of molecular changes suggests a mechanism for stretch activation, in which troponin bridges mechanically tug tropomyosin aside to relieve tropomyosin’s steric blocking of myosin–actin binding. This enables subsequent force production, with cross-bridge targeting further enhanced by stretch-induced lattice compression and thick-filament twisting. Similar linkages may operate in other muscle systems, such as mammalian cardiac muscle, where stretch activation is thought to aid in cardiac ejection. PMID:21148419

  14. The Social Work Role in Reducing 30-Day Readmissions: The Effectiveness of the Bridge Model of Transitional Care.

    PubMed

    Alvarez, Renae; Ginsburg, Jacob; Grabowski, Jessica; Post, Sharon; Rosenberg, Walter

    2016-04-01

    The hospital experience is taxing and confusing for patients and their families, particularly those with limited economic and social resources. This complexity often leads to disengagement, poor adherence to the plan of care, and high readmission rates. Novel approaches to addressing the complexities of transitional care are emerging as possible solutions. The Bridge Model is a person-centered, social work-led, interdisciplinary transitional care intervention that helps older adults safely transition from the hospital back to their homes and communities. The Bridge Model combines 3 key components-care coordination, case management, and patient engagement-which provide a seamless transition during this stressful time and improve the overall quality of transitional care for older adults, including reducing hospital readmissions. The post Affordable Care Act (ACA) and managed care environment's emphasis on value and quality support further development and expansion of transitional care strategies, such as the Bridge Model, which offer promising avenues to fulfil the triple aim by improving the quality of individual patient care while also impacting population health and controlling per capita costs.

  15. Extracellular ultrathin fibers sensitive to intracellular reactive oxygen species: Formation of intercellular membrane bridges

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jung, Se-Hui; Park, Jin-Young; Joo, Jung-Hoon

    2011-07-15

    Membrane bridges are key cellular structures involved in intercellular communication; however, dynamics for their formation are not well understood. We demonstrated the formation and regulation of novel extracellular ultrathin fibers in NIH3T3 cells using confocal and atomic force microscopy. At adjacent regions of neighboring cells, phorbol 12-myristate 13-acetate (PMA) and glucose oxidase induced ultrathin fiber formation, which was prevented by Trolox, a reactive oxygen species (ROS) scavenger. The height of ROS-sensitive ultrathin fibers ranged from 2 to 4 nm. PMA-induced formation of ultrathin fibers was inhibited by cytochalasin D, but not by Taxol or colchicine, indicating that ultrathin fibers mainlymore » comprise microfilaments. PMA-induced ultrathin fibers underwent dynamic structural changes, resulting in formation of intercellular membrane bridges. Thus, these fibers are formed by a mechanism(s) involving ROS and involved in formation of intercellular membrane bridges. Furthermore, ultrastructural imaging of ultrathin fibers may contribute to understanding the diverse mechanisms of cell-to-cell communication and the intercellular transfer of biomolecules, including proteins and cell organelles.« less

  16. Application of digital image correlation for long-distance bridge deflection measurement

    NASA Astrophysics Data System (ADS)

    Tian, Long; Pan, Bing; Cai, Youfa; Liang, Hui; Zhao, Yan

    2013-06-01

    Due to its advantages of non-contact, full-field and high-resolution measurement, digital image correlation (DIC) method has gained wide acceptance and found numerous applications in the field of experimental mechanics. In this paper, the application of DIC for real-time long-distance bridge deflection detection in outdoor environments is studied. Bridge deflection measurement using DIC in outdoor environments is more challenging than regular DIC measurements performed under laboratory conditions. First, much more image noise due to variations in ambient light will be presented in the images recorded in outdoor environments. Second, how to select the target area becomes a key factor because long-distance imaging results in a large field of view of the test object. Finally, the image acquisition speed of the camera must be high enough (larger than 100 fps) to capture the real-time dynamic motion of a bridge. In this work, the above challenging issues are addressed and several improvements were made to DIC method. The applicability was demonstrated by real experiments. Experimental results indicate that the DIC method has great potentials in motion measurement in various large building structures.

  17. Inspection Mechanism and Experimental Study of Prestressed Reverse Tension Method under PC Beam Bridge Anchorage

    NASA Astrophysics Data System (ADS)

    Peng, Zhang

    2018-03-01

    the prestress under anchorage is directly related to the structural security and performance of PC beam bridge. The reverse tension method is a kind of inspection which confirms the prestress by exerting reversed tension load on the exposed prestressing tendon of beam bridge anchoring system. The thesis elaborately expounds the inspection mechanism and mechanical effect of reverse tension method, theoretically analyzes the influential elements of inspection like tool anchorage deformation, compression of conjuncture, device glide, friction of anchorage loop mouth and elastic compression of concrete, and then presents the following formula to calculate prestress under anchorage. On the basis of model experiment, the thesis systematically studies some key issues during the reverse tension process of PC beam bridge anchorage system like the formation of stress-elongation curve, influential factors, judgment method of prestress under anchorage, variation trend and compensation scale, verifies the accuracy of mechanism analysis and demonstrates: the prestress under anchorage is less than or equal to 75% of the ultimate strength of prestressing tendon, the error of inspect result is less than 1%, which can meet with the demands of construction. The research result has provided theoretical basis and technical foundation for the promotion and application of reverse tension in bridge construction.

  18. Highly efficient model updating for structural condition assessment of large-scale bridges.

    DOT National Transportation Integrated Search

    2015-02-01

    For eciently updating models of large-scale structures, the response surface (RS) method based on radial basis : functions (RBFs) is proposed to model the input-output relationship of structures. The key issues for applying : the proposed method a...

  19. Minority Student Retention.

    ERIC Educational Resources Information Center

    Henderson, James C.

    1991-01-01

    Discusses the community college's role in Native American education. Describes recruitment, counseling, assessment, remedial, and outreach programs developed by San Juan College to help minority students succeed, and specifically help Native Americans bridge the worlds of public school, reservation, and university. Identifies keys to the programs'…

  20. 33 CFR 117.261 - Atlantic Intracoastal Waterway from St. Marys River to Key Largo.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... hour. (i) [Reserved] (j) NASA Railroad bridge, mile 876.6 at Kennedy Space Center. (1) The draw is not... Sections Affected, which appears in the Finding Aids section of the printed volume and at www.fdsys.gov. ...

  1. A low-noise measurement system for scanning thermal microscopy resistive nanoprobes based on a transformer ratio-arm bridge

    NASA Astrophysics Data System (ADS)

    Świątkowski, Michał; Wojtuś, Arkadiusz; Wielgoszewski, Grzegorz; Rudek, Maciej; Piasecki, Tomasz; Jóźwiak, Grzegorz; Gotszalk, Teodor

    2018-04-01

    Atomic force microscopy (AFM) is a widely used technology for the investigation and characterization of nanomaterials. Its functionality can be easily expanded by applying dedicated extension modules, which can measure the electrical conductivity or temperature of a sample. In this paper, we introduce a transformer ratio-arm bridge setup dedicated to AFM-based thermal imaging. One of the key features of the thermal module is the use of a low-power driving signal that prevents undesirable tip heating during resistance measurement, while the other is the sensor location in a ratio-arm transformer bridge working in the audio frequency range and ensuring galvanic isolation of the tip, enabling contact-mode scanning of electronic circuits. The proposed expansion module is compact and it can be integrated onto the AFM head close to the cantilever. The calibration process and the resolution of 11 mK of the proposed setup are shown.

  2. Damage assessment of bridge infrastructure subjected to flood-related hazards

    NASA Astrophysics Data System (ADS)

    Michalis, Panagiotis; Cahill, Paul; Bekić, Damir; Kerin, Igor; Pakrashi, Vikram; Lapthorne, John; Morais, João Gonçalo Martins Paulo; McKeogh, Eamon

    2017-04-01

    Transportation assets represent a critical component of society's infrastructure systems. Flood-related hazards are considered one of the main climate change impacts on highway and railway infrastructure, threatening the security and functionality of transportation systems. Of such hazards, flood-induced scour is a primarily cause of bridge collapses worldwide and one of the most complex and challenging water flow and erosion phenomena, leading to structural instability and ultimately catastrophic failures. Evaluation of scour risk under severe flood events is a particularly challenging issue considering that depth of foundations is very difficult to evaluate in water environment. The continual inspection, assessment and maintenance of bridges and other hydraulic structures under extreme flood events requires a multidisciplinary approach, including knowledge and expertise of hydraulics, hydrology, structural engineering, geotechnics and infrastructure management. The large number of bridges under a single management unit also highlights the need for efficient management, information sharing and self-informing systems to provide reliable, cost-effective flood and scour risk management. The "Intelligent Bridge Assessment Maintenance and Management System" (BRIDGE SMS) is an EU/FP7 funded project which aims to couple state-of-the art scientific expertise in multidisciplinary engineering sectors with industrial knowledge in infrastructure management. This involves the application of integrated low-cost structural health monitoring systems to provide real-time information towards the development of an intelligent decision support tool and a web-based platform to assess and efficiently manage bridge assets. This study documents the technological experience and presents results obtained from the application of sensing systems focusing on the damage assessment of water-hazards at bridges over watercourses in Ireland. The applied instrumentation is interfaced with an open-source platform that can offer a more economical remote monitoring solution. The results presented in this investigation provide an important guide for a multidisciplinary approach to bridge monitoring and can be used as a benchmark for the field application of cost-effective and robust sensing methods. This will deliver key information regarding the impact of water-related hazards at bridge structures through an integrated structural health monitoring and management system. Acknowledgement: The authors wish to acknowledge the financial support of the European Commission, through the Marie Curie action Industry-Academia Partnership and Pathways Network BRIDGE SMS (Intelligent Bridge Assessment Maintenance and Management System) - FP7-People-2013-IAPP- 612517.

  3. Studies on silicon NMR characterization and kinetic modeling of the structural evolution of siloxane-based materials and their applications in drug delivery and adsorption

    NASA Astrophysics Data System (ADS)

    Ambati, Jyothirmai

    This dissertation presents studies of the synthetic processes and applications of siloxane-based materials. Kinetic investigations of bridged organoalkoxysilanes that are precursors to organic-inorganic hybrid polysilsesquioxanes are a primary focus. Quick gelation despite extensive cyclization is found during the polymerization of bridged silane precursors except for silanes with certain short bridges. This work is an attempt to characterize and understand some of the distinct features of bridged silanes using experimental characterization, kinetic modeling and simulation. In addition to this, the dissertation shows how the properties of siloxane-materials can be engineered for drug delivery and adsorption. The phase behavior of polymerizing mixtures is first investigated to identify the solutions that favor kinetic characterization. Microphase separation is found to cause gradual loss of NMR signal for certain initial compositions. Distortionless Enhancement by Polarization Transfer 29Si NMR is employed to identify the products of polymerization of some short-bridged silanes under no signal loss conditions. This technique requires knowing indirect 29Si-1H scalar coupling constants which sometimes cannot be measured due to second-order effects. However, the B3LYP density functional method with 6-31G basis set is found to predict accurate 29Si- 1H coupling constants of organoalkoxysilanes and siloxanes. The scalar coupling constants thus estimated are employed to resolve non-trivial coupled NMR spectra and quantitative kinetic modeling is performed using the DEPT Si NMR transients. In order to investigate the role of the organic bridging group, the structural evolution of bridged and non-bridged silanes are compared using Monte Carlo simulations. Kinetic and simulation models suggest that cyclization plays a key role right from the onset of polymerization for bridged silanes even more than in non-bridged silanes. The simulations indicate that the carbosiloxane rings formed from short-bridged precursors slow down but do not prevent gelation. The tuning of siloxane-based materials for adsorption technologies are also discussed here. In the first example, antioxidant enzyme loading is investigated as a means to reduce oxidative stress generated by silica nanoparticle drug carriers. Materials are engineered for promising enzyme loading and protection from proteolysis. Second, the potential of copper sulfate impregnation to enhance adsorption of ammonia by silica is explored by molecular simulation. KEYWORDS: Sol-gel Polymerization, Kinetic Investigation, Si NMR, Bridged Silanes, DFT Calculations.

  4. A Bridge to the Future: Observations on Building a Digital Library.

    ERIC Educational Resources Information Center

    Gaunt, Marianne I.

    2002-01-01

    The experience of Rutgers University Libraries illustrates the extensive planning, work effort, possibilities, and investment required to develop the digital library. Examines these key areas: organizational structure; staff development needs; facilities and the new digital infrastructure; metadata standards/interoperability; digital collection…

  5. FutureTox III: Bridges for Translation

    EPA Science Inventory

    The present document describes key discussion points and outcomes of a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) Workshop, entitled FutureTox III1,2 that was held in Crystal City, Virginia, November 19-20, 2015. The workshop built on the many lessons l...

  6. 76 FR 62085 - Great Lakes Pilotage Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [USCG-2011-0948] Great Lakes Pilotage Advisory... notice announcing a Great Lakes Pilotage Advisory Committee (GLPAC) public meeting on October 18, 2011... regarding the bridge hour study, a key component of the statutory ratemaking authority of the Great Lakes...

  7. Adverse Outcome Pathways and Ecological Risk Assessment: Bridging to Population Level Effects

    EPA Science Inventory

    The viability of populations of plants and animals is a key focus for environmental regulation. Population-level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their con-specifics, competitor...

  8. Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies.

    PubMed

    Pampalona, J; Soler, D; Genescà, A; Tusell, L

    2010-01-05

    The cytokinesis-block micronucleus assay has emerged as a biomarker of chromosome damage relevant to cancer. Although it was initially developed to measure micronuclei, it is also useful for measuring nucleoplasmic bridges and nuclear buds. Abnormal nuclear morphologies are frequently observed in malignant tissues and short-term tumour cell cultures. Changes in chromosome structure and number resulting from chromosome instability are important factors in oncogenesis. Telomeres have become key players in the initiation of chromosome instability related to carcinogenesis by means of breakage-fusion-bridge cycles. To better understand the connection between telomere dysfunction and the appearance of abnormal nuclear morphologies, we have characterised the presence of micronuclei, nucleoplasmic bridges and nuclear buds in human mammary primary epithelial cells. These cells can proliferate beyond the Hayflick limit by spontaneously losing expression of the p16(INK4a) protein. Progressive telomere shortening leads to the loss of the capping function, and the appearance of end-to-end chromosome fusions that can enter into breakage-fusion-bridge cycles generating massive chromosomal instability. In human mammary epithelial cells, different types of abnormal nuclear morphologies were observed, however only nucleoplasmatic bridges and buds increased significantly with population doublings. Fluorescent in situ hybridisation using centromeric and painting specific probes for chromosomes with eroded telomeres has revealed that these chromosomes are preferentially included in the different types of abnormal nuclear morphologies observed, thus reflecting their common origin. Accordingly, real-time imaging of cell divisions enabled us to determine that anaphase bridge resolution was mainly through chromatin breakage and the formation of symmetric buds in daughter nuclei. Few micronuclei emerged in this cell system thus validating the scoring of nucleoplasmic bridges and nuclear buds for measuring chromosome instability in telomere-dysfunction cell environments.

  9. Bridge hosts for avian influenza viruses at the wildlife/domestic interface: an eco-epidemiological framework implemented in southern Africa.

    PubMed

    Caron, A; Grosbois, V; Etter, E; Gaidet, N; de Garine-Wichatitsky, M

    2014-12-01

    Wild terrestrial birds can act as potential local spreaders or bridge hosts for avian influenza viruses (AIVs) between waterfowl (the maintenance hosts of AIVs) and domestic avian populations in which AIVs may cause disease. Few studies have investigated this hypothesis, although it is an important knowledge gap in our understanding of AIV spread within socio-ecosystems. We designed a simple and reproducible approach in an agro-ecosystem in Zimbabwe based on: (1) bird counts at key target sites (i.e., wetlands, villages, intensive poultry production buildings and ostrich farms) to identify which wild birds species co-occur in these different sites and seasons when the risk of AIV transmission through these potential bridge hosts is maximal and (2) targeted sampling and testing for AIV infection in the identified potential bridge hosts. We found that 12 wild bird species represented the vast majority (79%) of co-occurrences in the different sites, whereas 230 bird species were recorded in this ecosystem. Specifically, three species - barn swallow, Hirundo rustica, red-billed quelea, Quelea quelea and cattle egret, Bubulcus ibis - represented the main potential bridge host species (65% of co-occurrences). In two out of these three species (i.e., barn swallow and red-billed quelea), we detected AIV infections, confirming that they can play a bridge function between waterfowl and domestic species in the ecosystem. Our approach can be easily implemented in other ecosystems to identify potential bridge hosts, and our results have implications in terms of surveillance, risk management and control of AIV spread in socio-ecosystems. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Optimum design of bridges with superelastic-friction base isolators against near-field earthquakes

    NASA Astrophysics Data System (ADS)

    Ozbulut, Osman E.; Hurlebaus, Stefan

    2010-04-01

    The seismic response of a multi-span continuous bridge isolated with novel superelastic-friction base isolator (S-FBI) is investigated under near-field earthquakes. The isolation system consists of a flat steel-Teflon sliding bearing and a superelastic NiTi shape memory alloy (SMA) device. Sliding bearings limit the maximum seismic forces transmitted to the superstructure to a certain value that is a function of friction coefficient of sliding interface. Superelastic SMA device provides restoring capability to the isolation system together with additional damping characteristics. The key design parameters of an S-FBI system are the natural period of the isolated, yielding displacement of SMA device, and the friction coefficient of the sliding bearings. The goal of this study is to obtain optimal values for each design parameter by performing sensitivity analyses of the isolated bridge. First, a three-span continuous bridge is modeled as a two-degrees-of-freedom with S-FBI system. A neuro-fuzzy model is used to capture rate-dependent nonlinear behavior of SMA device. A time-dependent method which employs wavelets to adjust accelerograms to match a target response spectrum with minimum changes on the other characteristics of ground motions is used to generate ground motions used in the simulations. Then, a set of nonlinear time history analyses of the isolated bridge is performed. The variation of the peak response quantities of the isolated bridge is shown as a function of design parameters. Also, the influence of temperature variations on the effectiveness of S-FBI system is evaluated. The results show that the optimum design of the isolated bridge with S-FBI system can be achieved by a judicious specification of design parameters.

  11. 4. Rockwork on north bank of the S. Platte River. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Rockwork on north bank of the S. Platte River. Located approximately 2.4 miles upstream from KeysTone Bridge and about 30 feet above river. View looking northwest from 70 fee. - Denver & Rio Grande Rockwork, East of South Platte, Waterton, Jefferson County, CO

  12. Cultural Pedagogy and Bridges to Literacy: Home and Kindergarten.

    ERIC Educational Resources Information Center

    Korat, Ofra

    2001-01-01

    Presents five key aspects of cultural pedagogy theory: social interactions, self-identity, externalization of inner thought, educational institutions, and narratives. Views these aspects as critical vehicles to fostering the child's literacy development. Notes that within this framework, great importance has been assigned to the cooperative link…

  13. Establishing a Community of Discourse through Social Norms

    ERIC Educational Resources Information Center

    Mullins, Sara Brooke

    2018-01-01

    While researchers, educators, state and national organizations, and policy makers are taking strides to help transform traditional mathematics classrooms into inquiry-based classrooms, they fail to address how to bridge the gap between creating discussions to developing mathematical discourse. One key component for producing inquiry-based…

  14. Adverse Outcome Pathways and Ecological Risk Assessment: Bridging to Population Level Effects, Journal Article

    EPA Science Inventory

    The viability of populations of plants and animals is a key focus for environmental regulation. Population-level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their con-specifics, competitor...

  15. 2007 TOXICOLOGY AND RISK ASSESSMENT ...

    EPA Pesticide Factsheets

    EPA has announced The 2007 Toxicology and Risk Assessment Conference Cincinnati Marriott North, West Chester (Cincinnati), OHApril 23- 26, 2007 - Click to register!The Annual Toxicology and Risk Assessment Conference is a unique meeting where several Government Agencies come together to discuss toxicology and risk assessment issues that are not only of concern to the government, but also to a broader audience including academia and industry. The theme of this year's conference is Emerging Issues and Challenges in Risk Assessment and the preliminary agenda includes: Plenary Sessions and prominent speakers (tentative) include: Issues of Emerging Chemical ContaminantsUncertainty and Variability in Risk Assessment Use of Mechanistic data in IARC evaluationsParallel Sessions:Uncertainty and Variability in Dose-Response Assessment Recent Advances in Toxicity and Risk Assessment of RDX The Use of Epidemiologic Data for Risk Assessment Applications Cumulative Health Risk Assessment:

  16. Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature.

    PubMed

    Takemura, Kazuhiro; Hanawa-Suetsugu, Kyoko; Suetsugu, Shiro; Kitao, Akio

    2017-07-28

    The BAR domain superfamily proteins sense or induce curvature in membranes. The inverse-BAR domain (I-BAR) is a BAR domain that forms a straight "zeppelin-shaped" dimer. The mechanisms by which IRSp53 I-BAR binds to and deforms a lipid membrane are investigated here by all-atom molecular dynamics simulation (MD), binding energy analysis, and the effects of mutation experiments on filopodia on HeLa cells. I-BAR adopts a curved structure when crystallized, but adopts a flatter shape in MD. The binding of I-BAR to membrane was stabilized by ~30 salt bridges, consistent with experiments showing that point mutations of the interface residues have little effect on the binding affinity whereas multiple mutations have considerable effect. Salt bridge formation increases the local density of lipids and deforms the membrane into a concave shape. In addition, the point mutations that break key intra-molecular salt bridges within I-BAR reduce the binding affinity; this was confirmed by expressing these mutants in HeLa cells and observing their effects. The results indicate that the stiffness of I-BAR is important for membrane deformation, although I-BAR does not act as a completely rigid template.

  17. BRIDGE - Behavioural reaching interfaces during daily antigravity activities through upper limb exoskeleton: Preliminary results.

    PubMed

    Gandolla, Marta; Costa, Andrea; Aquilante, Lorenzo; Gfoehler, Margit; Puchinger, Markus; Braghin, Francesco; Pedrocchi, Alessandra

    2017-07-01

    People with neuromuscular diseases such as muscular dystrophy experience a distributed and evolutive weakness in the whole body. Recent technological developments have changed the daily life of disabled people strongly improving the perceived quality of life, mostly concentrating on powered wheelchairs, so to assure autonomous mobility and respiratory assistance, essential for survival. The key concept of the BRIDGE project is to contrast the everyday experience of losing functions by providing them of a system able to exploit the best their own residual capabilities in arm movements so to keep them functional and autonomous as much as possible. BRIDGE is composed by a light, wearable and powered five degrees of freedom upper limb exoskeleton under the direct control of the user through a joystick or gaze control. An inverse kinematic model allows to determine joints position so to track patient desired hand position. BRIDGE prototype has been successfully tested in simulation environment, and by a small group of healthy volunteers. Preliminary results show a good tracking performance of the implemented control scheme. The interaction procedure was easy to understand, and the interaction with the system was successful.

  18. Measurement of Vehicle-Bridge-Interaction force using dynamic tire pressure monitoring

    NASA Astrophysics Data System (ADS)

    Chen, Zhao; Xie, Zhipeng; Zhang, Jian

    2018-05-01

    The Vehicle-Bridge-Interaction (VBI) force, i.e., the normal contact force of a tire, is a key component in the VBI mechanism. The VBI force measurement can facilitate experimental studies of the VBI as well as input-output bridge structural identification. This paper introduces an innovative method for calculating the interaction force by using dynamic tire pressure monitoring. The core idea of the proposed method combines the ideal gas law and a basic force model to build a relationship between the tire pressure and the VBI force. Then, unknown model parameters are identified by the Extended Kalman Filter using calibration data. A signal filter based on the wavelet analysis is applied to preprocess the effect that the tire rotation has on the pressure data. Two laboratory tests were conducted to check the proposed method's validity. The effects of different road irregularities, loads and forward velocities were studied. Under the current experiment setting, the proposed method was robust to different road irregularities, and the increase in load and velocity benefited the performance of the proposed method. A high-speed test further supported the use of this method in rapid bridge tests. Limitations of the derived theories and experiment were also discussed.

  19. The initial regime of drop coalescence

    NASA Astrophysics Data System (ADS)

    Anthony, Christopher; Harris, Michael; Basaran, Osman

    2017-11-01

    Drop coalescence plays a key role in both industry and nature. Consequently, study of the phenomenon has been the focus of numerous experimental, computational and theoretical works to date. In coalescence, two drops come into contact and a liquid bridge forms between them. As time advances, this bridge grows from microscopic to macroscopic scales. Despite the large volume of work dedicated to this problem, currently experiment, theory, and computation are not in perfect agreement with respect to the earliest times following the initial contact of the drops. Experiments report an initial regime where the radius of the connecting bridge grows linearly in time before a transition to either a Stokes regime or an inertial regime where either viscous or inertial forces balance capillary force. In the initial linear regime, referred to as the inertially-limited viscous regime, all three forces are thought to be important. This is in contrast to theory which predicts that all coalescence events begin in the Stokes regime. We use high accuracy numerical simulation to show that the existing discrepancy in the literature can be resolved by paying careful attention to the initial conditions that set the shape and size of the bridge connecting the two drops.

  20. Optic fiber sensor-based smart bridge cable with functionality of self-sensing

    NASA Astrophysics Data System (ADS)

    He, Jianping; Zhou, Zhi; Jinping, Ou

    2013-02-01

    Bridge cables, characterized by distributed large span, serving in harsh environment and vulnerability to random damage, are the key load-sustaining components of cable-based bridges. To ensure the safety of the bridge structure, it is critical to monitor the loading conditions of these cables under lengthwise random damages. Aiming at obtaining accurate monitoring at the critical points as well as the general information of the cable force distributed along the entire cable, this paper presents a study on cable force monitoring by combining optical fiber Bragg grating (FBG) sensors and Brillouin optical time domain analysis/reflectory (BOTDA/R) sensing technique in one single optical fiber. A smart FRP-OF-FBG rebar based cable was fabricated by protruding a FRP packaged OF-FBG sensor into the bridge cable. And its sensing characteristics, stability under high stress state temperature self-compensation as well as BOTDA/R distributed data improvement by local FBG sensors have been investigated. The results show that FRP-OF-FBG rebar in the smart cable can deform consistantly along with the steel wire and the cable force obtained from the optical fiber sensors agree well with theoretical value with relative error less than ±5%. Besides, the temperature self-compensation method provides a significant cost-effective technique for the FRP-OF-FBG based cables' in situ cable force measurement. And furthermore, potential damages of the bridge cable, e.g. wire breaking and corrosion, can be characterized and symbolized by the discontinuity and fluctuation of the distributed BOTDA data thereafter accuracy improved by local FBG sensors.

  1. Stamina and Clout Define This Rare Breed.

    ERIC Educational Resources Information Center

    Harrington-Lueker, Donna

    1991-01-01

    Takeover artists are a rare breed. Persons hired to put bankrupt school systems back on the road to academic solvency need stamina, clout, and plenty of experience. For all their state-given powers, takeover superintendents must identify key constituencies, build bridges, and promote belief in change from within. (MLH)

  2. Glossary for econometrics and epidemiology.

    PubMed

    Gunasekara, F Imlach; Carter, K; Blakely, T

    2008-10-01

    Epidemiologists and econometricians are often interested in similar topics-socioeconomic position and health outcomes-but the different languages that epidemiologists and economists use to interpret and discuss their results can create a barrier to mutual communication. This glossary defines key terms used in econometrics and epidemiology to assist in bridging this gap.

  3. Adverse Outcome Pathways and Ecological Risk Assessment: Bridging to Population Level Effects: Report of Pellston Workgroup 3

    EPA Science Inventory

    The continuing persistence and genetic diversity of populations is a key concern for environmental regulations. Population-level responses integrate the cumulative effects of chemical stressors on individuals as those individuals interact with and are affected by their con-speci...

  4. Neighborhood Science Stories: Bridging Science Standards and Urban Students' Lives

    ERIC Educational Resources Information Center

    Burke, Christopher

    2007-01-01

    Shelter, distribution of resources, adaptation and food sources are all key topics in teaching fifth grade students ecosystems. These terms and ideas are often presented in value neutral terms in the standard science curriculum. These terms have radically different connotations in different communities. In this paper students' fictional narrative…

  5. Bridging the Gap between Senior Citizens and Young People.

    ERIC Educational Resources Information Center

    Iannacone, George; Skelly, Joan

    1985-01-01

    This article describes a school district's programs that build relationships between the schools and the local senior citizens, including a grandparent program, developmental seminars, and a prom for senior citizens put on by the students. Also described are some keys to making such programs work, and the benefits. (DCS)

  6. Cases on Technological Adaptability and Transnational Learning: Issues and Challenges

    ERIC Educational Resources Information Center

    Mukerji, Siran, Ed.; Tripathi, Purnendu, Ed.

    2010-01-01

    Technology holds the key for bridging the gap between access to quality education and the need for enhanced learning experiences. This book contains case studies on divergent themes of personalized learning environments, inclusive learning for social change, innovative learning and assessment techniques, technology and international partnership…

  7. Opportunities and Challenges in Employing In Vitro-In Vivo Extrapolation (IVIVE) to the Tox21 Dataset

    EPA Science Inventory

    In vitro-in vivo extrapolation (IVIVE), or the process of using in vitro data to predict in vivo phenomena, provides key opportunities to bridge the disconnect between high-throughput screening data and real-world human exposures and potential health effects. Strategies utilizing...

  8. Reinforcing Deficit, Journeying toward Equity: Cultural Brokering in Family Engagement Initiatives

    ERIC Educational Resources Information Center

    Ishimaru, Ann M.; Torres, Kathryn E.; Salvador, Jessica E.; Lott, Joe, II; Williams, Dawn M. Cameron; Tran, Christine

    2016-01-01

    Families are key actors in efforts to improve student learning and outcomes, but conventional engagement efforts often disregard the cultural and social resources of nondominant families. Individuals who serve as cultural brokers play critical, though complex, roles bridging between schools and families. Using an equitable collaboration lens with…

  9. Flood Control Minnesota River, Minnesota, Mankato-North Mankato-Le Hillier. Design Memorandum Number 8. Part I. Location Study and Draft Supplement II to the Final Environmental Impact Statement for Bridge Relocations. Main Street, Trunk Highways 60 Bridge over the Minnesota River between Mankato and North Mankato.

    DTIC Science & Technology

    1981-06-01

    Technical Report No. 4, "Social and Economic Resources". 31. Mankato CBD - Existing land use in the Mankato CBD is com- prised of retail, service, and...encompassing Key City Urban Renewal Area. This renewal area contains 107 acres and includes the central portion of the CBD neighborhood. The enclosed...land for light industrial and commercial use in the southwestern portion of the CBD . Several new businesses have already located in the area, including

  10. Dibenzosiloles and 12H-indololo[3,2-d]naphtho[1,2-b][1]siloles: exploration of organic chromophores exhibiting efficient solid-state fluorescence.

    PubMed

    Shimizu, Masaki

    2015-02-01

    The construction of a diorganosilylene bridge over a biaryl moiety at the 2,2'-positions is a versatile strategy for fine-tuning its HOMO-LUMO energy gap, which is closely linked to the electronic and optical properties of the compounds. Therefore, there is growing interest in the use of silicon-bridged biaryl motifs as key cores of various types of advanced functional materials, such as light-emitting, semiconducting, photovoltaic, and sensing materials. To accelerate the advances of materials based on silicon-bridged biaryls, it is essential to create new classes of biaryls and explore their functions and properties. This Personal Account describes recent research on the development of organic chromophores based on functionalized dibenzosiloles and 12H-indololo[3,2-d]naphtho[1,2-b][1]siloles as solid-state emitters. Copyright © 2014 The Chemical Society of Japan and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Fiber optic chloride sensing: if corrosion's the problem, chloride sensing is the key

    NASA Astrophysics Data System (ADS)

    Fuhr, Peter L.; MacCraith, Brian D.; Huston, Dryver R.; Guerrina, Mario; Nelson, Matthew

    1997-09-01

    The use of chloride-based deicing agents to help clear US highways of roadway hazards leads to associated chemical related problems. Fouling of local rivers and streams due to runoff of the water borne chlorides is significant and has contributed to local ordances are attempting to force state agencies to reduce, if not eliminate, the use of these chlorides. With respect to the corrosion aspects of chloride application, cracks that occur in the roadway/bridge pavement allow water to seep into the pavement carrying the chloride to the rebar with the resultant increase in corrosion. The costs of this corrosion are considerable and have led to the widespread use of chloride/water impermeable membranes on roadways and especially within bridges. Fiber optic sensor have repeatedly been shown to provide measurement capabilities of parameters within such reinforced concrete structures. Development of a fiber optic chloride sensors capable of being embedded within a roadway or bridge deck is reported.

  12. Ruthenium-catalyzed intramolecular metathesis of dienes and its application in the synthesis of bridged and spiro azabicycles

    NASA Astrophysics Data System (ADS)

    Kuznetsov, N. Yu; Bubnov, Yu N.

    2015-07-01

    The review presents a historical excursion into catalytic alkene metathesis, covering the problems of history of the discovery of this process, as well as investigations on the properties, structure and reactivity of the most popular ruthenium catalysts for metathesis, mechanism of their action and decomposition. The main part covers studies devoted to the syntheses of bridged azabicyclic and 1-azaspirocyclic compounds comprising the intramolecular metathesis of dienes as the key step. The formation of a bicyclic skeleton of a series of natural bridged (cocaine, ferruginine, calystegines, and anatoxin-a) and spiro (pinnaic acids, halichlorine, hystrionicotoxin, and cephalotaxine) azabicycles, as well as their analogues and compounds with larger rings is demonstrated. The methods for the synthesis of diene precursors and the conditions for final assembling of the bicyclic compounds are considered in detail. The generalization of the literature data allows one to efficiently carry out the mentioned process taking into account the most important features. The bibliography includes 129 references.

  13. Patterns of preference and practice: bridging actors in wildfire response networks in the American Northwest.

    PubMed

    Faas, A J; Velez, Anne-Lise K; FitzGerald, Clare; Nowell, Branda L; Steelman, Toddi A

    2017-07-01

    The roles of bridging actors in emergency response networks can be important to disaster response outcomes. This paper is based on an evaluation of wildfire preparedness and response networks in 21 large-scale wildfire events in the wildland-urban interface near national forests in the American Northwest. The study investigated how key individuals in responder networks anticipated seeking out specific people in perceived bridging roles prior to the occurrence of wildfires, and then captured who in fact assumed these roles during actual large-scale events. It examines two plausible, but contradictory, bodies of theory-similarity and dissimilarity-that suggest who people might seek out as bridgers and who they would really go to during a disaster. Roughly one-half of all pre-fire nominations were consistent with similarity. Yet, while similarity is a reliable indicator of how people expect to organise, it does not hold up for how they organise during the real incident. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.

  14. Compact piezoelectric tripod manipulator based on a reverse bridge-type amplification mechanism

    NASA Astrophysics Data System (ADS)

    Na, Tae-Won; Choi, Jun-Ho; Jung, Jin-Young; Kim, Hyeong-Geon; Han, Jae-Hung; Park, Kwang-Chun; Oh, Il-Kwon

    2016-09-01

    We report a hierarchical piezoelectric tripod manipulator based on a reverse bridge-type displacement amplifier. The reverse bridge-type amplification mechanism is pre-strained by each piezo-stack actuator up to 60 μm and is cross-stacked in a series arrangement to make a compact and high-stroke manipulator having load-bearing characteristics. The designed manipulator with three degrees of freedom is compact with a height of 56.0 mm, a diameter of 48.6 mm and total weight of 115 g. It achieves a translational stroke of up to 880 μm in heaving motion and a tilting angle of up to 2.0° in rotational motion within the operating voltage and power range of the piezoelectric stack actuator. A key feature of the present design is built-in and pre-strained displacement amplification mechanisms integrated with piezoelectric stacked actuators, resulting in a compact tripod manipulator having exceptionally high stroke and load-bearing capacity.

  15. Pesticide Environmental Fate Research for the 21st Century: Building Bridges Between Laboratory and Field Studies at Varying Scales

    USDA-ARS?s Scientific Manuscript database

    Accurate determination of predicted environmental concentrations (PECs) is a continuing and often elusive goal of pesticide risk assessment. PECs are typically derived using simulation models that depend on laboratory generated data for key input parameters (t1/2, Koc, etc.). Model flexibility in ...

  16. Pesticide Environmental Fate Research for the 21st Century: Building Bridges Between Laboratory and Field Studies at Varying Scales

    USDA-ARS?s Scientific Manuscript database

    Accurate determination of predicted environmental concentrations (PECs) is a continuing and often elusive goal of pesticide risk assessment. PECs are typically derived using simulation models that depend on laboratory generated data for key input parameters (t1/2, Koc, etc.). Model flexibility in ev...

  17. 33 CFR 165.779 - Regulated Navigation Area; Columbus Day Weekend, Biscayne Bay, Miami, FL.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Rickenbacker Causeway Bridge and Coon Point, Elliot Key contained within an imaginary line connecting the...″ N, 80°12′06″ W; thence west to Point 6 in position 25°30′00″ N, 80°13′17″ W; thence northwest to...

  18. 33 CFR 165.779 - Regulated Navigation Area; Columbus Day Weekend, Biscayne Bay, Miami, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Rickenbacker Causeway Bridge and Coon Point, Elliot Key contained within an imaginary line connecting the...″ N, 80°12′06″ W; thence west to Point 6 in position 25°30′00″ N, 80°13′17″ W; thence northwest to...

  19. Culturally Responsive Mathematics Pedagogy: A Bridge Too Far?

    ERIC Educational Resources Information Center

    Sparrow, Len; Hurst, Chris

    2012-01-01

    The Swan Valley Cluster of Schools for the Make it Count project identified the professional learning of teachers as a key factor in improving the numeracy outcomes of urban Indigenous children. Two mentor teachers were assigned to support cluster teachers in planning and teaching mathematics during 2011. This paper reports on the initiative and…

  20. Bridging Behavioral Assessment and Behavioral Intervention: Finding Your Inner Behavior Analyst

    ERIC Educational Resources Information Center

    Johnson, LeAnne D.; Monn, Emily

    2015-01-01

    The persistence of challenging behaviors for some children highlights a need and an opportunity to explore several key principles of behavioral intervention that are necessary for effective decision- making when more personalized interventions must be layered on top of high-quality universal supports. In the absence of expert support,…

  1. Building Bridges with Families: Honoring the Mandates of IDEIA

    ERIC Educational Resources Information Center

    Coots, Jennifer J.

    2007-01-01

    Parent participation has been one of the key principles of the Individuals with Disabilities Education Improvement Act (IDEIA) since it was first authorized in 1975 as the Education for All Handicapped Children Act (EAHCA) and has continued through the most recent reauthorization in 2004. Parents of children with disabilities have decision making…

  2. Towards Developing an Industry-Validated Food Technology Curriculum in Afghanistan

    ERIC Educational Resources Information Center

    Ebner, Paul; McNamara, Kevin; Deering, Amanda; Oliver, Haley; Rahimi, Mirwais; Faisal, Hamid

    2017-01-01

    Afghanistan remains an agrarian country with most analyses holding food production and processing as key to recovery. To date, however, there are no public or private higher education departments focused on food technology. To bridge this gap, Herat University initiated a new academic department conferring BS degrees in food technology. Models for…

  3. It's a Puzzle: A Self-Organizing Activity

    ERIC Educational Resources Information Center

    McCollum, Janet; Barber, Catherine R.

    2017-01-01

    Helping students connect abstract concepts to concrete situations is often a challenge. Students who are unable to make the basic connections are at risk of spending the semester and beyond misunderstanding key points and their application. In this article, we provide a framework that includes debriefing, bridge building, and assimilation to help…

  4. Identification of Key Indicators of Quality in Afterschool Programs. CRESST Report 748

    ERIC Educational Resources Information Center

    Huang, Denise; La Torre, Deborah; Harven, Aletha; Huber, Lindsay Perez; Jiang, Lu; Leon, Seth; Oh, Christine

    2008-01-01

    Researchers and policymakers are increasingly interested in the issue of school accountability. Despite this, program standards for afterschool programs are not as fully developed as they are in other fields. This study bridges that gap and presents the results from a study that identifies benchmarks and indicators for high quality afterschool…

  5. The National Issues Forum: Bridging the Human Gap through Innovative Learning.

    ERIC Educational Resources Information Center

    McMahan, Eva M.

    The National Issues Forum model, a series of community based public discussions on key domestic issues, may be a partial solution to the "human gap" between growing complexity and a capacity to deal with it, by exemplifying "innovative learning." To engage in innovative learning, characterized by anticipation and participation,…

  6. Appalachian Bridges to the Baccalaureate: How Community Colleges Affect Transfer Success

    ERIC Educational Resources Information Center

    Decker, Amber K.

    2011-01-01

    Statement of the problem. Too few community college students who intend to transfer and earn a baccalaureate degree actually do. This is a problem because postsecondary education is a key factor in economic mobility, and community colleges enroll a disproportionate number of nontraditional, part-time and low-income students. Although individual…

  7. Bridging the Educational Research-Teaching Practice Gap: Foundations for Assessing and Developing Biochemistry Students' Visual Literacy

    ERIC Educational Resources Information Center

    Schonborn, Konrad J.; Anderson, Trevor R.

    2010-01-01

    External representations (ERs), such as diagrams, animations, and dynamic models are vital tools for communicating and constructing knowledge in biochemistry. To build a meaningful understanding of structure, function, and process, it is essential that students become visually literate by mastering key cognitive skills that are essential for…

  8. Health as a bridge to peace and trust in Myanmar: The 21st Century Panglong Conference.

    PubMed

    Tang, Kun; Zhao, Yingxi

    2017-06-28

    The twenty-first Century Panglong Conference, proposed by Aung San Suu Kyi and her National League for Democracy, has concluded with unsatisfactory results. This five-day conference attracted global attention and wide endorsements from the United Nations and many other key stakeholders. The broad framework of the peace dialogue included various social and economic issues. However, the implication of the conference on the health system strengthening efforts in ethnic areas was largely unknown. Although a "convergence model" was proposed by organizations in Thai-Myanmar borders as a roadmap for integrations of the national and ethnic health systems years ago, the genuine bottlenecks beneath have not been addressed. This commentary discussed the Panglong Conference and its implication for the health systems in ethnic regions, as well as the bottlenecks of a "peace process" in health sector. It outlined a few key steps to achieve health system convergence between national and ethnic health systems, the outcome of which will not only improve the health status of the ethnic regions, but also help strengthen mutual trust and understanding among peoples, as a powerful bridge for peace.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Monteleone, S.

    This three-volume report contains 90 papers out of the 102 that were presented at the Twenty-First Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, during the week of October 25--27, 1993. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Germany, Japan, Russia, Switzerland, Taiwan, and United Kingdom. The titles of the papers and the names of the authors have been updatedmore » and may differ from those that appeared in the final program of the meeting. Individual papers have been cataloged separately. This document, Volume 1 covers the following topics: Advanced Reactor Research; Advanced Instrumentation and Control Hardware; Advanced Control System Technology; Human Factors Research; Probabilistic Risk Assessment Topics; Thermal Hydraulics; and Thermal Hydraulic Research for Advanced Passive Light Water Reactors.« less

  10. Videos, tweet-ups, and training unite scientist communicators at Fall Meeting

    NASA Astrophysics Data System (ADS)

    Adams, Mary Catherine; Ramsayer, Kate

    2012-02-01

    AGU's public information office held several events at the 2011 Fall Meeting designed to train, recognize, and reward member scientists who communicate with, or want to communicate with, nonscience audiences. On Sunday, about 90 researchers gathered at the Marriott Marquis hotel for an all-day science communications training event covering topics including journalism from the insider's perspective, storytelling, and using humor to share science. On Wednesday a communications panel focusing specifically on climate science shared tips on communicating with audiences via TV and the Web, among other outlets. At a social media soiree Monday evening, geobloggers, Facebook fans, Twitter followers, and others met in person and talked about how to share news and research across the many platforms of the Internet. Later in the week, bloggers from AGU's blogosphere and other sites met for lunch to discuss the online Earth and space science community.

  11. Proceedings -- US Russian workshop on fuel cell technologies (in English;Russian)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baker, B.; Sylwester, A.

    1996-04-01

    On September 26--28, 1995, Sandia National Laboratories sponsored the first Joint US/Russian Workshop on Fuel Cell Technology at the Marriott Hotel in Albuquerque, New Mexico. This workshop brought together the US and Russian fuel cell communities as represented by users, producers, R and D establishments and government agencies. Customer needs and potential markets in both countries were discussed to establish a customer focus for the workshop. Parallel technical sessions defined research needs and opportunities for collaboration to advance fuel cell technology. A desired outcome of the workshop was the formation of a Russian/American Fuel Cell Consortium to advance fuel cellmore » technology for application in emerging markets in both countries. This consortium is envisioned to involve industry and national labs in both countries. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.« less

  12. A STUDY OF THE ACIDOSIS, BLOOD UREA, AND PLASMA CHLORIDES IN URANIUM NEPHRITIS IN THE DOG, AND OF THE PROTECTIVE ACTION OF SODIUM BICARBONATE.

    PubMed

    Goto, K

    1917-05-01

    1. The presence of an acidosis in dogs with experimental uranium nephritis is demonstrable by the Van Slyke-Stillman-Cullen method and that of Marriott. It is detected more readily by the former method. 2. This acidosis is associated with increase in the blood urea and plasma chlorides and with the appearance of albumin and casts in the urine. 3. The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium. It also diminishes the severity of the changes produced by uranium in the kidneys. 4. The oral administration of sodium bicarbonate to normal dogs raises the carbon dioxide content of the plasma as determined by the. Van Slyke-Stillman-Cullen method.

  13. Impact of proton transfer phenomena on the electronic structure of model Schiff bases: an AIM/NBO/ELF study.

    PubMed

    Panek, Jarosław J; Filarowski, Aleksander; Jezierska-Mazzarello, Aneta

    2013-10-21

    Understanding of the electronic structure evolution due to a proton dynamics is a key issue in biochemistry and material science. This paper reports on density functional theory calculations of Schiff bases containing short, strong intramolecular hydrogen bonds where the bridged proton is located: (i) at the donor site, (ii) strongly delocalized, and (iii) at the acceptor site. The mobility of the bridged proton and its influence on the molecular structure and properties of the chosen Schiff base derivatives have been investigated on the basis of Atoms in Molecules, Natural Bond Orbitals, and Electron Localization Function theories. It has been observed that the extent of the bridged proton delocalization is strongly modified by the steric and inductive effects present in the studied compounds introduced by various substituents. It has been shown that: (i) potential energy profiles for the proton motion are extremely dependent on the substitution of the aromatic ring, (ii) the topology of the free electron pairs present at the donor∕acceptor site, as well as their electron populations, are affected qualitatively by the bridged proton position, (iii) the distortion of the molecular structure due to the bridged proton dynamics includes the atomic charge fluctuations, which are in some cases non-monotonic, and (iv) topology of the ELF recognizes events of proton detachment from the donor and attachment to the acceptor. The quantitative and qualitative results shed light onto molecular consequences of the proton transfer phenomena.

  14. Inductance analysis of superconducting quantum interference devices with 3D nano-bridge junctions

    NASA Astrophysics Data System (ADS)

    Wang, Hao; Yang, Ruoting; Li, Guanqun; Wu, Long; Liu, Xiaoyu; Chen, Lei; Ren, Jie; Wang, Zhen

    2018-05-01

    Superconducting quantum interference devices (SQUIDs) with 3D nano-bridge junctions can be miniaturized into nano-SQUIDs that are able to sense a few spins in a large magnetic field. Among all device parameters, the inductance is key to the performance of SQUIDs with 3D nano-bridge junctions. Here, we measured the critical-current magnetic flux modulation curves of 12 devices with three design types using a current strip-line directly coupled to the SQUID loop. A best flux modulation depth of 71% was achieved for our 3D Nb SQUID. From the modulation curves, we extracted the inductance values of the current stripe-line in each design and compared them with the corresponding simulation results of InductEX. In this way, London penetration depths of 110 and 420 nm were determined for our Nb (niobium) and NbN (niobium nitride) films, respectively. Furthermore, we showed that inductances of 11 and 119 pH for Nb and NbN 3D nano-bridge junctions, respectively, dominated the total inductance of our SQUID loops which are 23 pH for Nb and 255 pH for NbN. A screening parameter being equal to one suggests optimal critical currents of 89.6 and 8.1 μA for Nb and NbN SQUIDs, respectively. Additionally, intrinsic flux noise of 110 ± 40 nΦ0/(Hz)1/2 is calculated for the Nb SQUIDs with 3D nano-bridge junctions by Langevin simulation.

  15. A discussion on the merits and limitations of using drive-by monitoring to detect localised damage in a bridge

    NASA Astrophysics Data System (ADS)

    Hester, David; González, Arturo

    2017-06-01

    Given the large number of bridges that currently have no instrumentation, there are obvious advantages in monitoring the condition of a bridge by analysing the response of a vehicle crossing it. As a result, the last two decades have seen a rise in the research attempting to solve the problem of identifying damage in a bridge from vehicle measurements. This paper examines the theoretical feasibility and practical limitations of a drive-by system in identifying damage associated to localised stiffness losses. First, the nature of the damage feature that is sought within the vehicle response needs to be characterized. For this purpose, the total vehicle response is considered to be made of 'static' and 'dynamic' components, and where the bridge has experienced a localised loss in stiffness, an additional 'damage' component. Understanding the nature of this 'damage' component is crucial to have an informed discussion on how damage can be identified and localised. Leveraging this new understanding, the authors propose a wavelet-based drive-by algorithm. By comparing the effect of the 'damage' component to other key effects defining the measurements such as 'vehicle speed', the 'road profile' and 'noise' on a wavelet contour plot, it is possible to establish if there is a frequency range where drive-by can be successful. The algorithm uses then specific frequency bands to improve the sensitivity to damage with respect to limitations imposed by Vehicle-Bridge vibrations. Recommendations on the selection of the mother wavelet and frequency band are provided. Finally, the paper discusses the impact of noise and road profile on the ability of the approach to identify damage and how periodic measurements can be effective at monitoring localised stiffness changes.

  16. Structural Bridges through Fold Space.

    PubMed

    Edwards, Hannah; Deane, Charlotte M

    2015-09-01

    Several protein structure classification schemes exist that partition the protein universe into structural units called folds. Yet these schemes do not discuss how these units sit relative to each other in a global structure space. In this paper we construct networks that describe such global relationships between folds in the form of structural bridges. We generate these networks using four different structural alignment methods across multiple score thresholds. The networks constructed using the different methods remain a similar distance apart regardless of the probability threshold defining a structural bridge. This suggests that at least some structural bridges are method specific and that any attempt to build a picture of structural space should not be reliant on a single structural superposition method. Despite these differences all representations agree on an organisation of fold space into five principal community structures: all-α, all-β sandwiches, all-β barrels, α/β and α + β. We project estimated fold ages onto the networks and find that not only are the pairings of unconnected folds associated with higher age differences than bridged folds, but this difference increases with the number of networks displaying an edge. We also examine different centrality measures for folds within the networks and how these relate to fold age. While these measures interpret the central core of fold space in varied ways they all identify the disposition of ancestral folds to fall within this core and that of the more recently evolved structures to provide the peripheral landscape. These findings suggest that evolutionary information is encoded along these structural bridges. Finally, we identify four highly central pivotal folds representing dominant topological features which act as key attractors within our landscapes.

  17. An Intramolecular Salt Bridge in Bacillus thuringiensis Cry4Ba Toxin Is Involved in the Stability of Helix α-3, Which Is Needed for Oligomerization and Insecticidal Activity.

    PubMed

    Pacheco, Sabino; Gómez, Isabel; Sánchez, Jorge; García-Gómez, Blanca-Ines; Soberón, Mario; Bravo, Alejandra

    2017-10-15

    Bacillus thuringiensis three-domain Cry toxins kill insects by forming pores in the apical membrane of larval midgut cells. Oligomerization of the toxin is an important step for pore formation. Domain I helix α-3 participates in toxin oligomerization. Here we identify an intramolecular salt bridge within helix α-3 of Cry4Ba (D111-K115) that is conserved in many members of the family of three-domain Cry toxins. Single point mutations such as D111K or K115D resulted in proteins severely affected in toxicity. These mutants were also altered in oligomerization, and the mutant K115D was more sensitive to protease digestion. The double point mutant with reversed charges, D111K-K115D, recovered both oligomerization and toxicity, suggesting that this salt bridge is highly important for conservation of the structure of helix α-3 and necessary to promote the correct oligomerization of the toxin. IMPORTANCE Domain I has been shown to be involved in oligomerization through helix α-3 in different Cry toxins, and mutations affecting oligomerization also elicit changes in toxicity. The three-dimensional structure of the Cry4Ba toxin reveals an intramolecular salt bridge in helix α-3 of domain I. Mutations that disrupt this salt bridge resulted in changes in Cry4Ba oligomerization and toxicity, while a double point reciprocal mutation that restored the salt bridge resulted in recovery of toxin oligomerization and toxicity. These data highlight the role of oligomer formation as a key step in Cry4Ba toxicity. Copyright © 2017 American Society for Microbiology.

  18. An innovative educational approach to professional development of medical laboratory scientists in Botswana.

    PubMed

    Magowe, Mabel Km; Ledikwe, Jenny H; Kasvosve, Ishmael; Martin, Robert; Thankane, Kabo; Semo, Bazghina-Werq

    2014-01-01

    To address the shortage of laboratory scientists in Botswana, an innovative, one-year academic bridging program was initiated at the University of Botswana, to advance diploma-holding laboratory technicians towards becoming laboratory scientists holding Bachelor's degrees. An evaluation was conducted, which described the outcomes of the program and the lessons learned from this novel approach to meeting human resource needs. This was a cross-sectional, mixed-methods evaluation. Qualitative interviews were conducted with graduates of the Bachelor of Science (BSc) Medical Laboratory Sciences (MLS) bridging program, along with the graduates' current supervisors, and key informants who were involved in program development or implementation. The quantitative data collected included a written questionnaire, completed by program graduates, with a retrospective pre-test/post-test survey of graduates' confidence, in terms of key laboratory competencies. The BSc MLS bridging program produced thirty-three laboratory scientists over 3 years. There was a significant increase in confidence among graduates, for specified competencies, after the program (P<0.05). Graduates reported acquiring new skills and, often, accepting new responsibilities at their former workplace, particularly in relationship to leadership and management. Five graduates enrolled in advanced degree programs. Most graduates assumed increased responsibility. However, only two graduates were promoted after completing the training program. The lessons learned include: the importance of stakeholder involvement, the need for data to identify local needs, financial sustainability, catering for the needs of adult learners, and ensuring a technically challenging work environment, conducive to the application of skills learned during training. A strong public health and clinical laboratory system is essential for the rapid detection and control of emerging health threats, and for patient care. However, there is a need to adequately prepare laboratory human resources, to ensure efficient and effective laboratory services. Advancement of laboratory technicians towards becoming laboratory scientists, through a bridging program, can provide the necessary skills within a short time.

  19. Bridging the Gap between Health and Social Care for Rare Diseases: Key Issues and Innovative Solutions.

    PubMed

    Castro, Raquel; Senecat, Juliette; de Chalendar, Myriam; Vajda, Ildikó; Dan, Dorica; Boncz, Béata

    2017-01-01

    Bridging the gaps between health and social care for rare diseases is not only necessary but crucial to increase the life expectancy, quality of life and autonomy of people living with a rare disease, supporting them in the full realisation of their fundamental human rights.The complexity of rare diseases, their strong relation to disability and the current unmet social and daily life needs of people living with a rare disease must not be underestimated and require urgent attention from all stakeholders involved in care provision, from healthcare to social and community services.The Commission Expert Group Recommendations to Support the Incorporation of Rare Diseases into Social Services and Policies, adopted unanimously in April 2016, by the representatives of European Member States and the other rare disease stakeholders, clearly set the tone for the need to promote measures that facilitate multidisciplinary, holistic, continuous, person-centred and participative care provision to people living with rare diseases.These recommendations, sided by other recent policy developments at European and national levels, represent an important policy step into approaching rare diseases' complex challenges in regards to holistic care provision.Innovative approaches aiming at bridging the gap between health, social and community service and support providers are currently being developed and tested in different European countries: standards of care, networks of expertise, case management services, one-stop-shop services, amongst others.These ongoing pilot approaches, presented in this chapter, have the power to inspire future policies and the effective and efficient implementation of holistic care pathways for people living with a rare disease, bringing about significant changes for patients, carers, care providers, competent authorities and the society at large.Nonetheless, the challenges to fully address this issue remain numerous and other key issues will also need to be taken into account when moving forward with the implementation of measures that aim at bridging the gaps between care providers and providing holistic care to people living with a rare disease.

  20. River sedimentation and channel bed characteristics in northern Ethiopia

    NASA Astrophysics Data System (ADS)

    Demissie, Biadgilgn; Billi, Paolo; Frankl, Amaury; Haile, Mitiku; Lanckriet, Sil; Nyssen, Jan

    2016-04-01

    Excessive sedimentation and flood hazard are common in ephemeral streams which are characterized by flashy floods. The purposes of this study was to investigate the temporal variability of bio-climatic factors in controlling sediment supply to downstream channel reaches and the effect of bridges on local hydro-geomorphic conditions in causing the excess sedimentation and flood hazard in ephemeral rivers of the Raya graben (northern Ethiopia). Normalized Difference Vegetation Index (NDVI) was analyzed for the study area using Landsat imageries of 1972, 1986, 2000, 2005, 2010, and 2012). Middle term, 1993-2011, daily rainfall data of three meteorological stations, namely, Alamata, Korem and Maychew, were considered to analyse the temporal trends and to calculate the return time intervals of rainfall intensity in 24 hours for 2, 5, 10 and 20 years using the log-normal and the Gumbel extreme events method. Streambed gradient and bed material grain size were measured in 22 river reaches (at bridges and upstream). In the study catchments, the maximum NDVI values were recorded in the time interval from 2000 to 2010, i.e. the decade during which the study bridges experienced the most severe excess sedimentation problems. The time series analysis for a few rainfall parameters do not show any evidence of rainfall pattern accountable for an increase in sediment delivery from the headwaters nor for the generation of higher floods with larger bedload transport capacities. Stream bed gradient and bed material grain size data were measured in order to investigate the effect of the marked decrease in width from the wide upstream channels to the narrow recently constructed bridges. The study found the narrowing of the channels due to the bridges as the main cause of the thick sedimentation that has been clogging the study bridges and increasing the frequency of overbank flows during the last 15 years. Key terms: sedimentation, ephemeral streams, sediment size, bridge clogging

  1. Recent advances in the development of a self-powered wireless sensor network for structural health prognosis

    NASA Astrophysics Data System (ADS)

    Godinez-Azcuaga, Valery F.; Inman, Daniel J.; Ziehl, Paul H.; Giurgiutiu, Victor; Nanni, Antonio

    2011-04-01

    This paper presents the most recent advances in the development of a self powered wireless sensor network for steel and concrete bridges monitoring and prognosis. This five-year cross-disciplinary project includes development and deployment of a 4-channel acoustic emission wireless node powered by structural vibration and wind energy harvesting modules. In order to accomplish this ambitious goal, the project includes a series of tasks that encompassed a variety of developments such as ultra low power AE systems, energy harvester hardware and especial sensors for passive and active acoustic wave detection. Key studies on acoustic emission produced by corrosion on reinforced concrete and by crack propagation on steel components to develop diagnosis tools and models for bridge prognosis are also a part of the project activities. It is important to mention that the impact of this project extends beyond the area of bridge health monitoring. Several wireless prototype nodes have been already requested for applications on offshore oil platforms, composite ships, combat deployable bridges and wind turbines. This project was awarded to a joint venture formed by Mistras Group Inc, Virginia Tech, University of South Carolina and University of Miami and is sponsored through the NIST-TIP Grant #70NANB9H007.

  2. The interdependence of Ca2+ activation, sarcomere length, and power output in the heart.

    PubMed

    McDonald, Kerry S

    2011-07-01

    Myocardium generates power to perform external work on the circulation; yet, many questions regarding intermolecular mechanisms regulating power output remain unresolved. Power output equals force × shortening velocity, and some interesting new observations regarding control of these two factors have arisen. While it is well established that sarcomere length tightly controls myocyte force, sarcomere length-tension relationships also appear to be markedly modulated by PKA-mediated phosphorylation of myofibrillar proteins. Concerning loaded shortening, historical models predict independent cross-bridge mechanics; however, it seems that the mechanical state of one population of cross-bridges affects the activity of other cross-bridges by, for example, recruitment of cross-bridges from the non-cycling pool to the cycling force-generating pool during submaximal Ca(2+) activation. This is supported by the findings that Ca(2+) activation levels, myofilament phosphorylation, and sarcomere length are all modulators of loaded shortening and power output independent of their effects on force. This fine tuning of power output probably helps optimize myocardial energetics and to match ventricular supply with peripheral demand; yet, the discernment of the chemo-mechanical signals that modulate loaded shortening needs further clarification since power output may be a key convergent point and feedback regulator of cytoskeleton and cellular signals that control myocyte growth and survival.

  3. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.

    PubMed

    P Barros, Emília; Malmstrom, Robert D; Nourbakhsh, Kimya; Del Rio, Jason C; Kornev, Alexandr P; Taylor, Susan S; Amaro, Rommie E

    2017-03-14

    Close-range electrostatic interactions that form salt bridges are key components of protein stability. Here we investigate the role of these charged interactions in modulating the allosteric activation of protein kinase A (PKA) via computational and experimental mutational studies of a conserved basic patch located in the regulatory subunit's B/C helix. Molecular dynamics simulations evidenced the presence of an extended network of fluctuating salt bridges spanning the helix and connecting the two cAMP binding domains in its extremities. Distinct changes in the flexibility and conformational free energy landscape induced by the separate mutations of Arg239 and Arg241 suggested alteration of cAMP-induced allosteric activation and were verified through in vitro fluorescence polarization assays. These observations suggest a mechanical aspect to the allosteric transition of PKA, with Arg239 and Arg241 acting in competition to promote the transition between the two protein functional states. The simulations also provide a molecular explanation for the essential role of Arg241 in allowing cooperative activation, by evidencing the existence of a stable interdomain salt bridge with Asp267. Our integrated approach points to the role of salt bridges not only in protein stability but also in promoting conformational transition and function.

  4. A novel bridge scour monitoring and prediction system

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Michalis, Panagiotis; Zhang, Hanqing

    2015-04-01

    Earth's surface is continuously shaped due to the action of geophysical flows. Erosion due to the flow of water in river systems has been identified as a key problem in preserving ecological health but also a threat to our built environment and critical infrastructure, worldwide. As an example, it has been estimated that a major reason for bridge failure is due to scour. Even though the flow past bridge piers has been investigated both experimentally and numerically, and the mechanisms of scouring are relatively understood, there still lacks a tool that can offer fast and reliable predictions. Most of the existing formulas for prediction of bridge pier scour depth are empirical in nature, based on a limited range of data or for piers of specific shape. In this work, the use of a novel methodology is proposed for the prediction of bridge scour. Specifically, the use of an Adaptive Neuro-Fuzzy Inference System (ANFIS) is proposed to estimate the scour depth around bridge piers. In particular, various complexity architectures are sequentially built, in order to identify the optimal for scour depth predictions, using appropriate training and validation subsets obtained from the USGS database (and pre-processed to remove incomplete records). The model has five variables, namely the effective pier width (b), the approach velocity (v), the approach depth (y), the mean grain diameter (D50) and the skew to flow. Simulations are conducted with data groups (bed material type, pier type and shape) and different number of input variables, to produce reduced complexity and easily interpretable models. Analysis and comparison of the results indicate that the developed ANFIS model has high accuracy and outstanding generalization ability for prediction of scour parameters. The effective pier width (as opposed to skew to flow) is amongst the most relevant input parameters for the estimation. Training of the system to new bridge geometries and flow conditions can be achieved by obtaining real time data, via novel electromagnetic sensors monitoring scour depth. Once the model is trained with data representative of the new system, bridge scour prediction can be performed for high/design flows or floods.

  5. STS-98 Commander Cockrell talks with Leinbach and Bridges at SLF

    NASA Technical Reports Server (NTRS)

    2001-01-01

    STS-98 Mission Commander Kenneth Cockrell (center) talks with Launch Director Michael Leinbach (red and white jacket) and Center Director Roy Bridges (right) at the Shuttle Landing Facility after the crew's arrival Sunday to complete preparations for launch. Behind him are, from left to right, Mission Specialist Thomas Jones; Tom Kwiatkowski, NASA, Johnson Space Center (JSC); and Robert Hanley, United Space Alliance, JSC. The crew also includes Pilot Mark Polansky and Mission Specialists Marsha Ivins and Robert Curbeam. STS-98 is the seventh construction flight to the International Space Station, carrying as payload the U.S. Lab Destiny, a key element in the construction of the ISS. Launch of STS-98 is scheduled for Feb. 7 at 6:11 p.m. EST.

  6. [Bridge role of Jingming (BL 1) for VDT asthenopia and brainfag based on human instinct].

    PubMed

    Zhang, Wei; Li, Huanan; Zhao, Na; Hai, Xinghua; Dong, Hua; Wang, Jingui

    2017-01-12

    To explore the bridge role of Jingming (BL 1) for video display terminal (VDT) asthenopia and brainfag. Ancient literature and modern scientific research on the acupoint have been analyzed and summarized so as to explore pressing the acupoint the instinct feedback of brain after asthenopia. It is demonstrated that Jingming (BL 1) is a key channel between eyes, brain and the outside world, and it is one of major feedback points of brain after asthenopia. In this paper we try to establish a new research thinking and ascertain it, namely Jingming (BL 1) reflecting the relationship between asthenopia and brainfag. We hope that it can provide some references for further research on cognizing brain through eye.

  7. USCA, a codeveloped piece of technology, is presented to Bridges, KSC Director, by Saputo, L-3 Commu

    NASA Technical Reports Server (NTRS)

    1997-01-01

    William Saputo, L-3 Communications, presents a new piece of technology, developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr. (second from left). The piece of technology being presented, the Universal Signal Conditioning Amplifier (USCA), is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets.

  8. Bridging graduate education in public health and the liberal arts.

    PubMed

    Aelion, C Marjorie; Gubrium, Aline C; Aulino, Felicity; Krause, Elizabeth L; Leatherman, Thomas L

    2015-03-01

    The University of Massachusetts Amherst is part of Five-Colleges Inc, a consortium that includes the university and four liberal arts colleges. Consortium faculty from the School of Public Health and Health Sciences at the university and from the colleges are working to bridge liberal arts with public health graduate education. We outline four key themes guiding this effort and exemplary curricular tools for innovative community-based and multidisciplinary academic and research programs. The structure of the consortium has created a novel trajectory for student learning and engagement, with important ramifications for pedagogy and professional practice in public health. We show how graduate public health education and liberal arts can, and must, work in tandem to transform public health practice in the 21st century.

  9. Social Indicators Research and Health-Related Quality of Life Research.

    ERIC Educational Resources Information Center

    Michalos, Alex C.

    2004-01-01

    The aim of this essay is to build a bridge between two intersecting areas of research, social indicators research on the one hand and health-related quality of life research on the other. The first substantive section of the paper introduces key concepts and definitions in the social indicators research tradition, e.g., social indicators,…

  10. A Pathway to Enhancing Professionalism: Building a Bridge between TAFE and University Early Childhood Qualifications

    ERIC Educational Resources Information Center

    Whitington, Victoria; Ebbeck, Marjory; Diamond, Alexandra; Yim, Hoi Yin Bonnie

    2009-01-01

    It has been argued that a key strategy to improve developmental and educational outcomes for young children is to increase the number of childcare staff with early childhood university degrees (Saracho & Spodek, 2007). In order to upgrade the qualifications of staff, a number of Australian universities provide pathways that enable graduates of…

  11. Do Facilitated Online Dual Credit Classes Result in Deep Learning?

    ERIC Educational Resources Information Center

    Stark Education Partnership, 2015

    2015-01-01

    This study, with funding from the Jennings Foundation, sought to answer the following broad research question: Do facilitated online dual credit courses result in deep learning? The answer to this question is key to addressing barriers many students face in bridging from high school to college. This report includes a descriptive case study that…

  12. No Teacher Is an Island: Bridging the Gap between Teachers' Professional Practice and Research Findings

    ERIC Educational Resources Information Center

    Herrington, Deborah; Daubenmire, Patrick L.

    2016-01-01

    Despite decades of research regarding best practices for the teaching and learning of chemistry, as well as two sets of national reform documents for science education, classroom instruction in high school chemistry classrooms remains largely unchanged. One key reason for this continued gap between research and practice is a reliance on…

  13. Through a Different Lens: Bridging the Expectation-Perception (Quality) Divide in Higher Education

    ERIC Educational Resources Information Center

    Yeo, Roland K.; Marquardt, Michael J.

    2011-01-01

    The paper draws on the underpinnings of SERVQUAL (a Service Quality measurement model) and explores three key aspects of service standards as adopted by an Engineering School in Singapore: customer orientation, course design/delivery and support services. Qualitative methodology was employed and data were collected by means of structured in-depth…

  14. Planting Aesthetics Seeds within the Journey of Children's Reading

    ERIC Educational Resources Information Center

    Cheng, Jui-Ching; Chen, Siou-Mi; Chou, Mei-Ju

    2015-01-01

    For the impact of parent-child reading picture books have on the child's learning process has been recommended at the elementary level as the appropriate strategies to bridge preschool and family education. The purpose of the study is firstly, to investigate the key virtues of the implementation in children's reading in preschool and at home;…

  15. Building Social Capital in Vulnerable Families: Success Markers of a School-Based Intervention Program

    ERIC Educational Resources Information Center

    Terrion, Jenepher Lennox

    2006-01-01

    Researchers suggest that key to addressing the needs of vulnerable families is to involve parents in their child's academic life. However, this article argues, it is not simply involvement that matters for the improved functioning of these families but the production of the three dimensions of social capital (bonding, bridging, and linking)…

  16. Bridging Worlds: Ethnic Minority Pupils in Catholic Schools in England

    ERIC Educational Resources Information Center

    Morris, Andrew B.

    2010-01-01

    Aggregated attainment data for each of the four Key Stages of the National Curriculum during 2006-07 are used to compare the performance of schools having differing proportions of ethnic minority pupils on roll. The data are for all maintained primary and secondary schools that completed the 2007 Annual Schools' Census. There are noticeable…

  17. Industrial strength herons: The Black-crowns of Baltimore

    USGS Publications Warehouse

    Erwin, R.M.; Anders, V.P.; Miles-Iverson, K.

    1990-01-01

    The largest night-heron colony in Maryland is located at the foot of the Key Bridge in Dundalk, Maryland, in an industrial area. Foraging herons were followed from the colony during May-July, . Most birds followed landed near industrial/urban sites. Availability of perches and lights (at night) may serve to enhance the heron's prey capture success.

  18. Bridging the Gap: The Struggle of One Hispanic Father

    ERIC Educational Resources Information Center

    Vasquez, Sarah

    2016-01-01

    Parent involvement has been shown to be one of the keys to student educational success, their ability to perform at a high level and persevere. The latest government statistics reveal that 53 million Hispanics now reside in the United States and 75 % of this population speaks Spanish at home [Cooper, M. (2014). "Hispanics in America and in…

  19. Opting out of the Bill: Voluntary Adequacy Funding in Maryland

    ERIC Educational Resources Information Center

    Finch, Maida A.; Goff, Peter; Houck, Eric

    2016-01-01

    The key to anticipating local response to state finance policy is to bridge knowledge of the state context with the specifications of the individual reform. Yet it is precisely this unique blend of social, political, and economic factors in any given state that makes the impact of school finance reforms difficult to predict, especially as these…

  20. Using Insider Research in MEd Final Projects to Bridge the Theory/Practice Gap

    ERIC Educational Resources Information Center

    Arar, Khalid

    2018-01-01

    This paper aims to identify key issues involved in MEd final project supervision and to highlight the potential of supervision from an academic institution to change educational reality through the postgraduate student-teachers' work-based final project as insider researchers in Israeli schools. It draws on analysis of case-study data from two…

  1. Bridging the Distance: The Use of Blogs as Reflective Learning Tools for Placement Students

    ERIC Educational Resources Information Center

    Wolf, Katharina

    2010-01-01

    This paper reviews the effectiveness of web logs ("blogs"), or online journals, within the context of a compulsory final-year placement unit for public relations students. The key goal behind the use of Web2.0 technology was to encourage ongoing, reflective practice via an exchange between students thereby limiting feelings of isolation…

  2. Spoken Language Processing Model: Bridging Auditory and Language Processing to Guide Assessment and Intervention

    ERIC Educational Resources Information Center

    Medwetsky, Larry

    2011-01-01

    Purpose: This article outlines the author's conceptualization of the key mechanisms that are engaged in the processing of spoken language, referred to as the spoken language processing model. The act of processing what is heard is very complex and involves the successful intertwining of auditory, cognitive, and language mechanisms. Spoken language…

  3. Developing Early Warning Indicators for the San Francisco Unified School District. Youth Data Archive Issue Brief

    ERIC Educational Resources Information Center

    John W. Gardner Center for Youth and Their Communities, 2011

    2011-01-01

    San Francisco's Bridge to Success (BtS) initiative brings together the City and County of San Francisco, the San Francisco Unified School District (SFUSD), the City College of San Francisco (CCSF), and key community organizations to promote postsecondary success for underrepresented students. Partners agree that the first step in achieving this…

  4. Building bridges with clinicians.

    PubMed

    Brady, Timothy S; Hankins, Robert W

    2003-06-01

    Clinical and ancillary staff need and welcome the opportunity to be involved in healthcare financial management. To provide them with the financial tools they need, a group of clinical and nonclinical professionals identified the key components of a curriculum that addressed financial, managerial, and cost accounting, along with training objectives that include understanding cost allocation, trend analysis, and variance analysis.

  5. Developing Alternative Placement Criteria for English Courses at City College of San Francisco. Issue Brief

    ERIC Educational Resources Information Center

    Castrechini, Sebastian

    2013-01-01

    Recognizing the need to improve postsecondary access and success for underrepresented populations, the San Francisco Unified School District (SFUSD), City College of San Francisco (CCSF), the City and County of San Francisco, and key community organizations formed the Bridge to Success initiative in 2009. The John W. Gardner Center for Youth and…

  6. Welcome to Our World: Bridging Youth Development Research in Nonprofit and Academic Communities

    ERIC Educational Resources Information Center

    Bialeschki, M. Deborah; Conn, Michael

    2011-01-01

    This commentary discusses the emergence of youth development research and evaluation in the nonprofit arena over the past 10 to 15 years. Included in this discussion is the establishment of the context for youth development research in nonprofits, a brief description of key examples of research from three youth nonprofits that illustrate the…

  7. NITARP: Bridging the Gap Between the Traditional Science Classroom and Authentic Research

    NASA Astrophysics Data System (ADS)

    Stalnaker, Olivia K.; Evans, Sam; Rutherford, Thomas; Taylor, John; Rebull, Luisa

    2018-01-01

    In this poster, the differences between what occurs in the traditional secondary science classroom and what happens in the actual research world is examined. Secondary classroom teachers generally have limited, if any, research experience beyond what is presented through their undergraduate college lab coursework. A disparity exists between classroom laboratory work and professional research. Opportunities like NITARP provide research elements that bridge this gap. NITARP teams are in a unique situation, joining a small team working alongside Caltech researchers on cutting edge investigations in astrophysics. In this poster it is shown how the NITARP program provides key components and experiences to expand the skill sets that teachers bring to their classrooms, bridging the gap between the typical secondary classroom and the world of the professional researcher. The NASA/IPAC program immerses participating teachers into a year-long training experience via online and face-to-face learning that translates into enhanced instruction at the secondary level. This work was made possible through the NASA/IPAC Teacher Archive Research Program (NITARP) and was funded by NASA Astrophysics Data Program.

  8. Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch

    PubMed Central

    Blees, Andreas; Reichel, Katrin; Trowitzsch, Simon; Fisette, Olivier; Bock, Christoph; Abele, Rupert; Hummer, Gerhard; Schäfer, Lars V.; Tampé, Robert

    2015-01-01

    Salt bridges in lipid bilayers play a decisive role in the dynamic assembly and downstream signaling of the natural killer and T-cell receptors. Here, we describe the identification of an inter-subunit salt bridge in the membrane within yet another key component of the immune system, the peptide-loading complex (PLC). The PLC regulates cell surface presentation of self-antigens and antigenic peptides via molecules of the major histocompatibility complex class I. We demonstrate that a single salt bridge in the membrane between the transporter associated with antigen processing TAP and the MHC I-specific chaperone tapasin is essential for the assembly of the PLC and for efficient MHC I antigen presentation. Molecular modeling and all-atom molecular dynamics simulations suggest an ionic lock-switch mechanism for the binding of TAP to tapasin, in which an unfavorable uncompensated charge in the ER-membrane is prevented through complex formation. Our findings not only deepen the understanding of the interaction network within the PLC, but also provide evidence for a general interaction principle of dynamic multiprotein membrane complexes in immunity. PMID:26611325

  9. Iterating between Tools to Create and Edit Visualizations.

    PubMed

    Bigelow, Alex; Drucker, Steven; Fisher, Danyel; Meyer, Miriah

    2017-01-01

    A common workflow for visualization designers begins with a generative tool, like D3 or Processing, to create the initial visualization; and proceeds to a drawing tool, like Adobe Illustrator or Inkscape, for editing and cleaning. Unfortunately, this is typically a one-way process: once a visualization is exported from the generative tool into a drawing tool, it is difficult to make further, data-driven changes. In this paper, we propose a bridge model to allow designers to bring their work back from the drawing tool to re-edit in the generative tool. Our key insight is to recast this iteration challenge as a merge problem - similar to when two people are editing a document and changes between them need to reconciled. We also present a specific instantiation of this model, a tool called Hanpuku, which bridges between D3 scripts and Illustrator. We show several examples of visualizations that are iteratively created using Hanpuku in order to illustrate the flexibility of the approach. We further describe several hypothetical tools that bridge between other visualization tools to emphasize the generality of the model.

  10. Distinct dissociation kinetics between ion pairs: Solvent-coordinate free-energy landscape analysis.

    PubMed

    Yonetani, Yoshiteru

    2015-07-28

    Different ion pairs exhibit different dissociation kinetics; however, while the nature of this process is vital for understanding various molecular systems, the underlying mechanism remains unclear. In this study, to examine the origin of different kinetic rate constants for this process, molecular dynamics simulations were conducted for LiCl, NaCl, KCl, and CsCl in water. The results showed substantial differences in dissociation rate constant, following the trend kLiCl < kNaCl < kKCl < kCsCl. Analysis of the free-energy landscape with a solvent reaction coordinate and subsequent rate component analysis showed that the differences in these rate constants arose predominantly from the variation in solvent-state distribution between the ion pairs. The formation of a water-bridging configuration, in which the water molecule binds to an anion and a cation simultaneously, was identified as a key step in this process: water-bridge formation lowers the related dissociation free-energy barrier, thereby increasing the probability of ion-pair dissociation. Consequently, a higher probability of water-bridge formation leads to a higher ion-pair dissociation rate.

  11. The Role of Simulation in Pedagogies of Higher Education for the Health Professions: Through a Practice-Based Lens

    ERIC Educational Resources Information Center

    Rooney, Donna; Hopwood, Nick; Boud, David; Kelly, Michelle

    2015-01-01

    The preparation of future professionals for practice is a key focus of higher education institutions. Among a range of approaches is the use of simulation pedagogies. While simulation is often justified as a direct bridge between higher education and professional practice, this paper questions this easy assumption. It develops a conceptually…

  12. Dodgy Data, Language Invisibility and the Implications for Social Inclusion: A Critical Analysis of Indigenous Student Language Data in Queensland Schools

    ERIC Educational Resources Information Center

    Dixon, Sally; Angelo, Denise

    2014-01-01

    As part of the "Bridging the Language Gap" project undertaken with 86 State and Catholic schools across Queensland, the language competencies of Indigenous students have been found to be "invisible" in several key and self-reinforcing ways in school system data. A proliferation of inaccurate, illogical and incomplete data…

  13. 31. VIEW NORTHEAST OF OPERATING MACHINERY. GEAR 'C5' IS AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. VIEW NORTHEAST OF OPERATING MACHINERY. GEAR 'C5' IS AT LOWER LEFT AND EMERGENCY BRAKE MECHANISM ON PEDESTAL AT CENTER. NOTE LOWER EQUALIZING LINKAGE FOR COUNTERWEIGHT AT LEFT CENTER OF PHOTOGRAPH - THIS WAS A KEY COMPONENT OF STRAUSS' PATENT PARALLOGRAM LINKAGE - Tomlinson Bridge, Spanning Quinnipiac River at Forbes Street (U.S. Route 1), New Haven, New Haven County, CT

  14. English Articulation between the San Francisco Unified School District and the City College of San Francisco. Youth Data Archive Issue Brief

    ERIC Educational Resources Information Center

    Gurantz, Oded

    2012-01-01

    San Francisco's Bridge to Success (BtS) initiative brings together the City and County of San Francisco, the San Francisco Unified School District (SFUSD), the City College of San Francisco (CCSF), and key community organizations to promote postsecondary success for underrepresented students. Various working groups, each comprised of staff from…

  15. Improving pharmacy revenue integrity.

    PubMed

    Carmody, Jennifer J; Townsend, Kyle; Schwartz, Kathy

    2013-09-01

    Billings Clinic learned the following important lessons in implementing a pharmacy revenue integrity initiative: Integrate pharmacy data as fully as possible. Audit and review pharmacy data regularly to validate the data and identify key areas where education can be provided to support accuracy and compliance. Use technology to bridge gaps between pharmacy data, such as gaps in billable units and billed units. Establish data governance workflows.

  16. Integrated remote sensing and visualization (IRSV) system for transportation infrastructure operations and management, phase one, volume 5 : automated management bridge information system.

    DOT National Transportation Integrated Search

    2009-12-01

    This volume focuses on one of the key components of the IRSV system, i.e., the AMBIS module. This module serves as one of : the tools used in this study to translate raw remote sensing data in the form of either high-resolution aerial photos or v...

  17. Social Capital and Educational Organizing in Low Income, Minority, and New Immigrant Communities: Can the University Strengthen Community Organizations?

    ERIC Educational Resources Information Center

    Krasner, Michael Alan; Pierre-Louis, Francois

    2009-01-01

    A college-based program that combines training, direct support, and technical assistance was found to produce significant gains in bonding and bridging social capital and key political attributes among low-income, minority, and immigrant groups organizing to enhance their power to influence public school politics and policies in New York City.…

  18. Better Policies for Dual Language Learners: Bridging Research, Policy, Implementation, and Classroom Practice

    ERIC Educational Resources Information Center

    Williams, Conor P.

    2015-01-01

    On December 11, 2014, "New America" convened a group of leading experts on dual language learners (DLLs) to launch its new Dual Language Learners National Work Group. The group aimed to address three questions: (1) What are the key best practices for dual language learner instruction, policy, and research?; (2) What are the areas of…

  19. The Digital Divide and Inequities for Students with Disabilities: Needed… A Bridge over Troubled Waters!

    ERIC Educational Resources Information Center

    Tyson, Patricia A.

    2015-01-01

    One of the key concepts of the NCLB legislation was the improvement of student achievement in academics with the use of technology (NCLB, 2001). Ironically, the NCLB mandate of accountability has not provided the necessary resources for achieving its goals, and students with disabilities are, in fact, being left behind. Therefore, the law is…

  20. Enacting Key Skills-Based Curricula in Secondary Education: Lessons from a Technology-Mediated, Group-Based Learning Initiative

    ERIC Educational Resources Information Center

    Johnston, Keith; Conneely, Claire; Murchan, Damian; Tangney, Brendan

    2015-01-01

    Bridge21 is an innovative approach to learning for secondary education that was originally conceptualised as part of a social outreach intervention in the authors' third-level institution whereby participants attended workshops at a dedicated learning space on campus focusing on a particular model of technology-mediated group-based learning. This…

  1. The bridge of iconicity: from a world of experience to the experience of language.

    PubMed

    Perniss, Pamela; Vigliocco, Gabriella

    2014-09-19

    Iconicity, a resemblance between properties of linguistic form (both in spoken and signed languages) and meaning, has traditionally been considered to be a marginal, irrelevant phenomenon for our understanding of language processing, development and evolution. Rather, the arbitrary and symbolic nature of language has long been taken as a design feature of the human linguistic system. In this paper, we propose an alternative framework in which iconicity in face-to-face communication (spoken and signed) is a powerful vehicle for bridging between language and human sensori-motor experience, and, as such, iconicity provides a key to understanding language evolution, development and processing. In language evolution, iconicity might have played a key role in establishing displacement (the ability of language to refer beyond what is immediately present), which is core to what language does; in ontogenesis, iconicity might play a critical role in supporting referentiality (learning to map linguistic labels to objects, events, etc., in the world), which is core to vocabulary development. Finally, in language processing, iconicity could provide a mechanism to account for how language comes to be embodied (grounded in our sensory and motor systems), which is core to meaningful communication.

  2. The bridge of iconicity: from a world of experience to the experience of language

    PubMed Central

    Perniss, Pamela; Vigliocco, Gabriella

    2014-01-01

    Iconicity, a resemblance between properties of linguistic form (both in spoken and signed languages) and meaning, has traditionally been considered to be a marginal, irrelevant phenomenon for our understanding of language processing, development and evolution. Rather, the arbitrary and symbolic nature of language has long been taken as a design feature of the human linguistic system. In this paper, we propose an alternative framework in which iconicity in face-to-face communication (spoken and signed) is a powerful vehicle for bridging between language and human sensori-motor experience, and, as such, iconicity provides a key to understanding language evolution, development and processing. In language evolution, iconicity might have played a key role in establishing displacement (the ability of language to refer beyond what is immediately present), which is core to what language does; in ontogenesis, iconicity might play a critical role in supporting referentiality (learning to map linguistic labels to objects, events, etc., in the world), which is core to vocabulary development. Finally, in language processing, iconicity could provide a mechanism to account for how language comes to be embodied (grounded in our sensory and motor systems), which is core to meaningful communication. PMID:25092668

  3. Arthroscopically Assisted Reconstruction of Acute Acromioclavicular Joint Dislocations: Anatomic AC Ligament Reconstruction With Protective Internal Bracing—The “AC-RecoBridge” Technique

    PubMed Central

    Izadpanah, Kaywan; Jaeger, Martin; Ogon, Peter; Südkamp, Norbert P.; Maier, Dirk

    2015-01-01

    An arthroscopically assisted technique for the treatment of acute acromioclavicular joint dislocations is presented. This pathology-based procedure aims to achieve anatomic healing of both the acromioclavicular ligament complex (ACLC) and the coracoclavicular ligaments. First, the acromioclavicular joint is reduced anatomically under macroscopic and radiologic control and temporarily transfixed with a K-wire. A single-channel technique using 2 suture tapes provides secure coracoclavicular stabilization. The key step of the procedure consists of the anatomic repair of the ACLC (“AC-Reco”). Basically, we have observed 4 patterns of injury: clavicular-sided, acromial-sided, oblique, and midportion tears. Direct and/or transosseous ACLC repair is performed accordingly. Then, an X-configured acromioclavicular suture tape cerclage (“AC-Bridge”) is applied under arthroscopic assistance to limit horizontal clavicular translation to a physiological extent. The AC-Bridge follows the principle of internal bracing and protects healing of the ACLC repair. The AC-Bridge is tightened on top of the repair, creating an additional suture-bridge effect and promoting anatomic ACLC healing. We refer to this combined technique of anatomic ACLC repair and protective internal bracing as the “AC-RecoBridge.” A detailed stepwise description of the surgical technique, including indications, technical pearls and pitfalls, and potential complications, is given. PMID:26052493

  4. Building Bridges to Diversity in Graduate Physics & Astronomy: The Fisk-Vanderbilt Masters-to-PhD Bridge Program

    NASA Astrophysics Data System (ADS)

    Stassun, Keivan G.

    2006-12-01

    We describe the Fisk-Vanderbilt Masters-to-PhD Bridge program as a successful model for effective partnerships with minority-serving institutions toward significantly broadening the participation of underrepresented groups in the physical sciences. The program couples targeted recruitment with active retention strategies, and is built upon a clearly defined structure that is flexible enough to address individual student needs while maintaining clearly communicated baseline standards for student performance. A key precept of the program’s philosophy is to eliminate passivity in student mentoring; students are deliberately groomed to successfully transition into the PhD program through active involvement in research experiences with future PhD advisers, coursework that demonstrates competency in core PhD subject areas, and frequent interactions with joint mentoring committees. This approach allows student progress and performance to be monitored and evaluated in a more holistic manner than usually afforded by limited metrics such as standardized tests. Since its inception in 2004, the program has attracted a total of 18 underrepresented students, with a retention rate of 90%. Recent research indicates that minority students are nearly twice as likely as non-minority students to seek a Masters degree en route to the PhD. In essence, the Bridge program described here builds upon this increasingly important pathway, with a dedicated mentoring process designed to ensure that the Masters-to-PhD transition is a successful one.

  5. A density functional theory study on the active center of Fe-only hydrogenase: characterization and electronic structure of the redox states.

    PubMed

    Liu, Zhi-Pan; Hu, P

    2002-05-08

    We have carried out extensive density functional theory (DFT) calculations for possible redox states of the active center in Fe-only hydrogenases. The active center is modeled by [(H(CH(3))S)(CO)(CN(-))Fe(p)(mu-DTN)(mu-CO)Fe(d)(CO)(CN(-))(L)](z)() (z is the net charge in the complex; Fe(p)= the proximal Fe, Fe(d) = the distal Fe, DTN = (-SCH(2)NHCH(2)S-), L is the ligand that bonds with the Fe(d) at the trans position to the bridging CO). Structures of possible redox states are optimized, and CO stretching frequencies are calculated. By a detailed comparison of all the calculated structures and the vibrational frequencies with the available experimental data, we find that (i) the fully oxidized, inactive state is an Fe(II)-Fe(II) state with a hydroxyl (OH(-)) group bonded at the Fe(d), (ii) the oxidized, active state is an Fe(II)-Fe(I) complex which is consistent with the assignment of Cao and Hall (J. Am. Chem. Soc. 2001, 123, 3734), and (iii) the fully reduced state is a mixture with the major component being a protonated Fe(I)-Fe(I) complex and the other component being its self-arranged form, Fe(II)-Fe(II) hydride. Our calculations also show that the exogenous CO can strongly bond with the Fe(II)-Fe(I) species, but cannot bond with the Fe(I)-Fe(I) complex. This result is consistent with experiments that CO tends to inhibit the oxidized, active state, but not the fully reduced state. The electronic structures of all the redox states have been analyzed. It is found that a frontier orbital which is a mixing state between the e(g) of Fe and the 2 pi of the bridging CO plays a key role concerning the reactivity of Fe-only hydrogenases: (i) it is unoccupied in the fully oxidized, inactive state, half-occupied in the oxidized, active state, and fully occupied in the fully reduced state; (ii) the e(g)-2 pi orbital is a bonding state, and this is the key reason for stability of the low oxidation states, such as Fe(I)-Fe(I) complexes; and (iii) in the e(g)-2 pi orbital more charge accumulates between the bridging CO and the Fe(d) than between the bridging CO and the Fe(p), and the occupation increase in this orbital will enhance the bonding between the bridging CO and the Fe(d), leading to the bridging-CO shift toward the Fe(d).

  6. Bridging Graduate Education in Public Health and the Liberal Arts

    PubMed Central

    Gubrium, Aline C.; Aulino, Felicity; Krause, Elizabeth L.; Leatherman, Thomas L.

    2015-01-01

    The University of Massachusetts Amherst is part of Five-Colleges Inc, a consortium that includes the university and four liberal arts colleges. Consortium faculty from the School of Public Health and Health Sciences at the university and from the colleges are working to bridge liberal arts with public health graduate education. We outline four key themes guiding this effort and exemplary curricular tools for innovative community-based and multidisciplinary academic and research programs. The structure of the consortium has created a novel trajectory for student learning and engagement, with important ramifications for pedagogy and professional practice in public health. We show how graduate public health education and liberal arts can, and must, work in tandem to transform public health practice in the 21st century. PMID:25706025

  7. Emerging perspectives in social neuroscience and neuroeconomics of aging

    PubMed Central

    Mather, Mara

    2011-01-01

    This article introduces the special issue of ‘Social Cognitive and Affective Neuroscience’ on Aging Research, and offers a broad conceptual and methodological framework for considering advances in life course research in social neuroscience and neuroeconomics. The authors highlight key areas of inquiry where aging research is raising new insights about how to conceptualize and examine critical questions about the links between cognition, emotion and motivation in social and economic behavior, as well as challenges that need to be addressed when taking a life course perspective in these fields. They also point to several emerging approaches that hold the potential for addressing these challenges, through bridging approaches from laboratory and population-based science, bridging inquiry across life stages and expanding measurement of core psychological phenotypes. PMID:21482573

  8. Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly.

    PubMed

    Shalaeva, Daria N; Dibrova, Daria V; Galperin, Michael Y; Mulkidjanian, Armen Y

    2015-05-27

    Binding of cytochrome c, released from the damaged mitochondria, to the apoptotic protease activating factor 1 (Apaf-1) is a key event in the apoptotic signaling cascade. The binding triggers a major domain rearrangement in Apaf-1, which leads to oligomerization of Apaf-1/cytochrome c complexes into an apoptosome. Despite the availability of crystal structures of cytochrome c and Apaf-1 and cryo-electron microscopy models of the entire apoptosome, the binding mode of cytochrome c to Apaf-1, as well as the nature of the amino acid residues of Apaf-1 involved remain obscure. We investigated the interaction between cytochrome c and Apaf-1 by combining several modeling approaches. We have applied protein-protein docking and energy minimization, evaluated the resulting models of the Apaf-1/cytochrome c complex, and carried out a further analysis by means of molecular dynamics simulations. We ended up with a single model structure where all the lysine residues of cytochrome c that are known as functionally-relevant were involved in forming salt bridges with acidic residues of Apaf-1. This model has revealed three distinctive bifurcated salt bridges, each involving a single lysine residue of cytochrome c and two neighboring acidic resides of Apaf-1. Salt bridge-forming amino acids of Apaf-1 showed a clear evolutionary pattern within Metazoa, with pairs of acidic residues of Apaf-1, involved in bifurcated salt bridges, reaching their highest numbers in the sequences of vertebrates, in which the cytochrome c-mediated mechanism of apoptosome formation seems to be typical. The reported model of an Apaf-1/cytochrome c complex provides insights in the nature of protein-protein interactions which are hard to observe in crystallographic or electron microscopy studies. Bifurcated salt bridges can be expected to be stronger than simple salt bridges, and their formation might promote the conformational change of Apaf-1, leading to the formation of an apoptosome. Combination of structural and sequence analyses provides hints on the evolution of the cytochrome c-mediated apoptosis.

  9. Mental Imagery and Post-Traumatic Stress Disorder: A Neuroimaging and Experimental Psychopathology Approach to Intrusive Memories of Trauma

    PubMed Central

    Clark, Ian A.; Mackay, Clare E.

    2015-01-01

    This hypothesis and theory paper presents a pragmatic framework to help bridge the clinical presentation and neuroscience of intrusive memories following psychological trauma. Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD). However, key questions, including those involving etiology, remain. In particular, we know little about the brain mechanisms involved in why only some moments of the trauma return as intrusive memories while others do not. We first present an overview of the patient experience of intrusive memories and the neuroimaging studies that have investigated intrusive memories in PTSD patients. Next, one mechanism of how to model intrusive memories in the laboratory, the trauma film paradigm, is examined. In particular, we focus on studies combining the trauma film paradigm with neuroimaging. Stemming from the clinical presentation and our current understanding of the processes involved in intrusive memories, we propose a framework in which an intrusive memory comprises five component parts; autobiographical (trauma) memory, involuntary recall, negative emotions, attention hijacking, and mental imagery. Each component part is considered in turn, both behaviorally and from a brain imaging perspective. A mapping of these five components onto our understanding of the brain is described. Unanswered questions that exist in our understanding of intrusive memories are considered using the proposed framework. Overall, we suggest that mental imagery is key to bridging the experience, memory, and intrusive recollection of the traumatic event. Further, we suggest that by considering the brain mechanisms involved in the component parts of an intrusive memory, in particular mental imagery, we may be able to aid the development of a firmer bridge between patients’ experiences of intrusive memories and the clinical neuroscience behind them. PMID:26257660

  10. Geometry and Integrability

    NASA Astrophysics Data System (ADS)

    Mason, Lionel; Nutku, Yavuz

    2003-12-01

    Based on courses held at the Feza GÜrsey Institute, this collection of survey articles introduces advanced graduate students to an exciting area on the border of mathematics and mathematical physics. Including articles by key names such as Calogero, Donagi and Mason, it features the algebro-geometric material from Donagi as well as the twistor space methods in Woodhouse's contribution, forming a bridge between the pure mathematics and the more physical approaches.

  11. Role of School Employees' Mental Health Knowledge in Interdisciplinary Collaborations to Support the Academic Success of Students Experiencing Mental Health Distress

    ERIC Educational Resources Information Center

    Frauenholtz, Susan; Mendenhall, Amy N.; Moon, Jungrim

    2017-01-01

    Children with mental health disorders are at elevated risk of deleterious academic outcomes. The school, acting as a bridge between home and community, is a key site for identification and intervention with children experiencing mental health distress. Yet survey research has indicated that many teachers and other school staff have limited…

  12. Common pressure vessel development for the nickel hydrogen technology

    NASA Technical Reports Server (NTRS)

    Holleck, G.

    1981-01-01

    The design of a pressure vessel nickel hydrogen cell is described. The cell has the following key features: it eliminates electrolyte bridging; provides for independent electrolyte management for each unit stack; provides for independent oxygen management for each unit stack; has good heat dissipation; has a mechanically sound and practical interconnection; and has the maximum in common with state of the art individual pressure vessel technology.

  13. 33 CFR 80.757 - Suncoast Keys, FL to Horseshoe Point, FL.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... latitude 29°16.6′ N. longitude 83°06.7′ W. 300° true to the shoreline of Hog Island. (h) A north-south line... formed by the centerline of Highway 44 Bridge over the Salt River. (c) A north-south line drawn through Crystal River Entrance Daybeacon 25 across the river entrance. (d) A north-south line drawn through the...

  14. 33 CFR 80.757 - Suncoast Keys, FL to Horseshoe Point, FL.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... latitude 29°16.6′ N. longitude 83°06.7′ W. 300° true to the shoreline of Hog Island. (h) A north-south line... formed by the centerline of Highway 44 Bridge over the Salt River. (c) A north-south line drawn through Crystal River Entrance Daybeacon 25 across the river entrance. (d) A north-south line drawn through the...

  15. 33 CFR 80.757 - Suncoast Keys, FL to Horseshoe Point, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... latitude 29°16.6′ N., longitude 83°06.7′ W., 300° true to the shoreline of Hog Island. (h) A north-south... formed by the centerline of Highway 44 Bridge over the Salt River. (c) A north-south line drawn through Crystal River Entrance Daybeacon 25 across the river entrance. (d) A north-south line drawn through the...

  16. 33 CFR 80.757 - Suncoast Keys, FL to Horseshoe Point, FL.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... latitude 29°16.6′ N. longitude 83°06.7′ W. 300° true to the shoreline of Hog Island. (h) A north-south line... formed by the centerline of Highway 44 Bridge over the Salt River. (c) A north-south line drawn through Crystal River Entrance Daybeacon 25 across the river entrance. (d) A north-south line drawn through the...

  17. KSC-2012-1322

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to industry partners and stakeholders during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 people from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  18. KSC-2012-1325

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Phil McAlister, NASA's director of Commercial Spaceflight Development, talks to industry partners and stakeholders during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 people from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  19. KSC-2012-1333

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to media during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 industry partners and stakeholders from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  20. KSC-2012-1326

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to industry partners and stakeholders during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 people from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  1. KSC-2012-1332

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to media during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 industry partners and stakeholders from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  2. KSC-2012-1330

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to media during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 industry partners and stakeholders from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  3. KSC-2012-1323

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to industry partners and stakeholders during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 people from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  4. KSC-2012-1331

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Ed Mango, program manager for NASA's Commercial Crew Program CCP, talks to media during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 industry partners and stakeholders from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  5. KSC-2012-1324

    NASA Image and Video Library

    2012-02-14

    COCOA BEACH, Fla. -- Phil McAlister, NASA's director of Commercial Spaceflight Development, talks to industry partners and stakeholders during a preproposal conference at the Courtyard Marriott in Cocoa Beach, Fla. The meeting focused on information related to NASA's release of the Commercial Crew Integrated Capability CCiCap Announcement for Proposals on Feb. 7. More than 50 people from 25 aerospace companies attended the conference to find out what the space agency would be looking for in terms of milestones, funding, schedules, strategies, safety cultures, business modules and eventual flight certification standards of integrated crew space transportation systems. The goal of the CCiCap is to develop an indigenous U.S. transportation system that can safely, affordably and routinely fly to low Earth orbit destinations, including the International Space Station. Proposals are due March 23 and NASA plans to award multiple Space Act Agreements, valued from $300 million to $500 million each, toward the development of fully integrated commercial crew transportation systems in the summer of 2012. For more information, visit www.nasa.gov/commercialcrew Photo credit: Kim Shiflett

  6. High-performance light-emitting diodes based on carbene-metal-amides

    NASA Astrophysics Data System (ADS)

    Di, Dawei; Romanov, Alexander S.; Yang, Le; Richter, Johannes M.; Rivett, Jasmine P. H.; Jones, Saul; Thomas, Tudor H.; Abdi Jalebi, Mojtaba; Friend, Richard H.; Linnolahti, Mikko; Bochmann, Manfred; Credgington, Dan

    2017-04-01

    Organic light-emitting diodes (OLEDs) promise highly efficient lighting and display technologies. We introduce a new class of linear donor-bridge-acceptor light-emitting molecules, which enable solution-processed OLEDs with near-100% internal quantum efficiency at high brightness. Key to this performance is their rapid and efficient utilization of triplet states. Using time-resolved spectroscopy, we establish that luminescence via triplets occurs within 350 nanoseconds at ambient temperature, after reverse intersystem crossing to singlets. We find that molecular geometries exist at which the singlet-triplet energy gap (exchange energy) is close to zero, so that rapid interconversion is possible. Calculations indicate that exchange energy is tuned by relative rotation of the donor and acceptor moieties about the bridge. Unlike other systems with low exchange energy, substantial oscillator strength is sustained at the singlet-triplet degeneracy point.

  7. Bridging the Divide- Adventures of an academic entrepreneur

    NASA Astrophysics Data System (ADS)

    Venkatesan, Thirumalai

    2017-01-01

    Academic research and entrepreneurship are simultaneously synergistic and conflicting as careers and my talk is about the challenges of bridging these careers. After a research career at Bell Labs and Bellcore which led to the invention of the Pulsed Laser Deposition Process I started Neocera as a company to translate products arising from academic research. Leaving Bell and building the company in Maryland as a Professor at UMD was a great learning experience. Managing creative people to productize, focusing on marketing/sales and managing cash flows constituted a world significantly different from what one encounters in the academia. Survival is key and a hasty decision can be the difference between success and bankruptcy. In my talk I will discuss the various lessons I learnt from the process and how one handles the challenges to eventually make an economic and societal impact.

  8. Bridging implementation, knowledge, and ambition gaps to eliminate tuberculosis in the United States and globally.

    PubMed

    Castro, Kenneth G; LoBue, Philip

    2011-03-01

    We reflect on remarkable accomplishments in global tuberculosis (TB) control and identify persistent obstacles to the successful elimination of TB from the United States and globally. One hundred and twenty nine years after Koch's discovery of the etiologic agent of TB, this health scourge continues to account for 9.4 million cases and 1.7 million deaths annually worldwide. Implementation of the Directly Observed Treatment Short-course strategy from 1995 through 2009 has saved 6 million lives. TB control is increasingly being achieved in countries with high-income economies, yet TB continues to plague persons living in countries with low-income and lower-middle-income economies. To accelerate progress against the global effects of disease caused by TB and achieve its elimination, we must bridge 3 key gaps in implementation, knowledge, and ambition.

  9. Enabling campus grids with open science grid technology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weitzel, Derek; Bockelman, Brian; Swanson, David

    2011-01-01

    The Open Science Grid is a recognized key component of the US national cyber-infrastructure enabling scientific discovery through advanced high throughput computing. The principles and techniques that underlie the Open Science Grid can also be applied to Campus Grids since many of the requirements are the same, even if the implementation technologies differ. We find five requirements for a campus grid: trust relationships, job submission, resource independence, accounting, and data management. The Holland Computing Center's campus grid at the University of Nebraska-Lincoln was designed to fulfill the requirements of a campus grid. A bridging daemon was designed to bring non-Condormore » clusters into a grid managed by Condor. Condor features which make it possible to bridge Condor sites into a multi-campus grid have been exploited at the Holland Computing Center as well.« less

  10. Materials science. Materials that couple sensing, actuation, computation, and communication.

    PubMed

    McEvoy, M A; Correll, N

    2015-03-20

    Tightly integrating sensing, actuation, and computation into composites could enable a new generation of truly smart material systems that can change their appearance and shape autonomously. Applications for such materials include airfoils that change their aerodynamic profile, vehicles with camouflage abilities, bridges that detect and repair damage, or robotic skins and prosthetics with a realistic sense of touch. Although integrating sensors and actuators into composites is becoming increasingly common, the opportunities afforded by embedded computation have only been marginally explored. Here, the key challenge is the gap between the continuous physics of materials and the discrete mathematics of computation. Bridging this gap requires a fundamental understanding of the constituents of such robotic materials and the distributed algorithms and controls that make these structures smart. Copyright © 2015, American Association for the Advancement of Science.

  11. "Cooking the books"--behavior-based safety at the San Francisco Bay Bridge.

    PubMed

    Brown, Garrett D; Barab, Jordan

    2007-01-01

    Practitioners of Behavior-Based Safety (BBS) claim dramatic reductions in worker injuries and illnesses through modifying workers' "unsafe behaviors." This case study of a BBS program implemented by KFM, a giant construction consortium rebuilding the eastern span of the San Francisco Bay Bridge in California, documents how BBS was used to suppress reporting of worker injuries and illnesses on site. The key elements of KFM's BBS "injury prevention" strategy included: 1) cash incentives to workers and supervisors who do not report injuries; 2) reprisals and threats of reprisals against those employees who do report injuries; 3) selection and use of employer friendly occupational health clinics and workers compensation insurance administrators; 4) strict limits on the activities of contract industrial hygiene consultants; and 5) a secretive management committee that decides whether reported injuries and illnesses are legitimate and recordable. KFM reported injury and illness rates 55% to 72% lower than other bridge builders in the Bay Area, but the California Division of Occupational Safety and Health (Cal/OSHA) issued Willful citations to the consortium in June 2006 for failing to record 13 worker injuries on its "OSHA Log 300," as required by law.

  12. Cardiac transplantation: candidate identification, evaluation, and management.

    PubMed

    McCalmont, Vicki; Ohler, Linda

    2008-01-01

    For more than 40 years, cardiac transplantation has been a treatment option for patients with severe heart failure in whom optimal medical management is no longer effective. Critical care nurses are integrally involved in the care of patients with severe heart failure who may benefit from cardiac transplantation and are in a special position to recognize potential candidates for transplantation. Understanding patient selection criteria, the evaluation process, and how patients are managed while awaiting transplantation is key to the knowledge and skills required. It is also important to understand the allocation of donor hearts as part of this process. The waiting period for a suitable donor heart can be long and a patient's condition may deteriorate, requiring an increase in pharmacologic bridges with intravenous inotropic agents or mechanical bridges with circulatory assist devices. Critical care nurses become important as a personal bridge to transplantation through their education of patients and families and helping them cope with their fears during the waiting period. Critical care nurses who possess knowledge of patient selection and organ allocation processes along with the skills of caring for this complex patient population can contribute to better outcomes for patients with heart failure who may be candidates for cardiac transplantation.

  13. Design and Synthesis of Novel Block Copolymers for Efficient Opto-Electronic Applications

    NASA Technical Reports Server (NTRS)

    Sun, Sam-Shajing; Fan, Zhen; Wang, Yiqing; Taft, Charles; Haliburton, James; Maaref, Shahin

    2002-01-01

    It has been predicted that nano-phase separated block copolymer systems containing electron rich donor blocks and electron deficient acceptor blocks may facilitate the charge carrier separation and migration in organic photovoltaic devices due to improved morphology in comparison to polymer blend system. This paper presents preliminary data describing the design and synthesis of a novel Donor-Bridge-Acceptor (D-B-A) block copolymer system for potential high efficient organic optoelectronic applications. Specifically, the donor block contains an electron donating alkyloxy derivatized polyphenylenevinylene (PPV), the acceptor block contains an electron withdrawing alkyl-sulfone derivatized polyphenylenevinylene (PPV), and the bridge block contains an electronically neutral non-conjugated aliphatic hydrocarbon chain. The key synthetic strategy includes the synthesis of each individual block first, then couple the blocks together. While the donor block stabilizes and facilitates the transport of the holes, the acceptor block stabilizes and facilitates the transport of the electrons, the bridge block is designed to hinder the probability of electron-hole recombination. Thus, improved charge separation and stability are expected with this system. In addition, charge migration toward electrodes may also be facilitated due to the potential nano-phase separated and highly ordered block copolymer ultra-structure.

  14. δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity.

    PubMed

    Peigneur, Steve; Paolini-Bertrand, Marianne; Gaertner, Hubert; Biass, Daniel; Violette, Aude; Stöcklin, Reto; Favreau, Philippe; Tytgat, Jan; Hartley, Oliver

    2014-12-19

    Conotoxins are venom peptides from cone snails with multiple disulfide bridges that provide a rigid structural scaffold. Typically acting on ion channels implicated in neurotransmission, conotoxins are of interest both as tools for pharmacological studies and as potential new medicines. δ-Conotoxins act by inhibiting inactivation of voltage-gated sodium channels (Nav). Their pharmacology has not been extensively studied because their highly hydrophobic character makes them difficult targets for chemical synthesis. Here we adopted an acid-cleavable solubility tag strategy that facilitated synthesis, purification, and directed disulfide bridge formation. Using this approach we readily produced three native δ-conotoxins from Conus consors plus two rationally designed hybrid peptides. We observed striking differences in Nav subtype selectivity across this group of compounds, which differ in primary structure at only three positions: 12, 23, and 25. Our results provide new insights into the structure-activity relationships underlying the Nav subtype selectivity of δ-conotoxins. Use of the acid-cleavable solubility tag strategy should facilitate synthesis of other hydrophobic peptides with complex disulfide bridge patterns. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Redox cofactors insertion in prokaryotic molybdoenzymes occurs via a conserved folding mechanism

    PubMed Central

    Arias-Cartin, Rodrigo; Ceccaldi, Pierre; Schoepp-Cothenet, Barbara; Frick, Klaudia; Blanc, Jean-Michel; Guigliarelli, Bruno; Walburger, Anne; Grimaldi, Stéphane; Friedrich, Thorsten; Receveur-Brechot, Véronique; Magalon, Axel

    2016-01-01

    A major gap of knowledge in metalloproteins is the identity of the prefolded state of the protein before cofactor insertion. This holds for molybdoenzymes serving multiple purposes for life, especially in energy harvesting. This large group of prokaryotic enzymes allows for coordination of molybdenum or tungsten cofactors (Mo/W-bisPGD) and Fe/S clusters. Here we report the structural data on a cofactor-less enzyme, the nitrate reductase respiratory complex and characterize the conformational changes accompanying Mo/W-bisPGD and Fe/S cofactors insertion. Identified conformational changes are shown to be essential for recognition of the dedicated chaperone involved in cofactors insertion. A solvent-exposed salt bridge is shown to play a key role in enzyme folding after cofactors insertion. Furthermore, this salt bridge is shown to be strictly conserved within this prokaryotic molybdoenzyme family as deduced from a phylogenetic analysis issued from 3D structure-guided multiple sequence alignment. A biochemical analysis with a distantly-related member of the family, respiratory complex I, confirmed the critical importance of the salt bridge for folding. Overall, our results point to a conserved cofactors insertion mechanism within the Mo/W-bisPGD family. PMID:27886223

  16. Experimental design for the evaluation of high-T(sub c) superconductive thermal bridges in a sensor satellite

    NASA Technical Reports Server (NTRS)

    Scott, Elaine P.; Lee, Kasey M.

    1994-01-01

    Infrared sensor satellites, which consist of cryogenic infrared sensor detectors, electrical instrumentation, and data acquisition systems, are used to monitor the conditions of the earth's upper atmosphere in order to evaluate its present and future changes. Currently, the electrical connections (instrumentation), which act as thermal bridges between the cryogenic infrared sensor and the significantly warmer data acquisition unit of the sensor satellite system, constitute a significant portion of the heat load on the cryogen. As a part of extending the mission life of the sensor satellite system, the researchers at the National Aeronautics and Space Administration's Langley Research Center (NASA-LaRC) are evaluating the effectiveness of replacing the currently used manganin wires with high-temperature superconductive (HTS) materials as the electrical connections (thermal bridges). In conjunction with the study being conducted at NASA-LaRC, the proposed research is to design a space experiment to determine the thermal savings on a cryogenic subsystem when manganin leads are replaced by HTS leads printed onto a substrate with a low thermal conductivity, and to determine the thermal conductivities of HTS materials. The experiment is designed to compare manganin wires with two different types of superconductors on substrates by determining the heat loss by the thermal bridges and providing temperature measurements for the estimation of thermal conductivity. A conductive mathematical model has been developed and used as a key tool in the design process and subsequent analysis.

  17. Bye to Thule, For Now

    NASA Image and Video Library

    2017-12-08

    On March 31, the P-3 departed Thule, Greenland. IceBridge teams flew a science transit flight to Kangerlussaq, Greenland, where missions will be based for the next several weeks before returning to Thule. Along the route, instruments surveyed several targets of opportunity including two ground tracks of the Ice, Cloud and land Elevation Satellite (ICESat) and several glaciers (Rink, Kangerdlugssuaq, Jakobshavn and Russell), turning up great data and spectacular views. March 29 was another perfect day for a land ice flight. The P-3 flew between deep canyons and over glaciers along the northwest coast of Greenland. But before the start of land ice flights, IceBridge reached a key milestone over sea ice. On March 28, IceBridge flew its eighth sea ice flight marking the completion of all high- and medium-priority sea ice missions planned from Thule. Among the sea ice missions was a science transit back from Fairbanks to Thule on March 25, during which the P-3 surveyed in complete darkness. Researchers watched the scanning pattern of the green lasers on the sea ice below and the beautiful Aurora Borealis above. To learn more about Ice Bridge go to: www.nasa.gov/mission_pages/icebridge/news/spr11/index.html NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook

  18. Disruption of Alluvial Fan Processes in a Cascade Range Stream, and Attempts to Address the Resulting Problems...

    NASA Astrophysics Data System (ADS)

    DeVries, P.

    2016-12-01

    Alluvial fan processes have been altered in two ways on Mouse Creek, tributary of the Sauk River, WA. A county road and low profile bridge were built in the vicinity of a large scale break in slope, and a berm was built upstream along one bank to confine flows. The system has a high sediment load from episodic mass wasting upstream. Over 10 years of survey data and analyses provide a case study of aggradation, flooding, and avulsion processes above the road crossing, and of efforts to address the resulting problems. The berm precluded fan deposition upstream, and appears to have shifted the deposition zone downstream closer to the bridge, leading to an avulsion and impacting upstream migration of salmon to spawning habitat. In addition, the bed elevation of the channel is now higher than the historic fan surface on the other side of the berm. The bridge was raised to reduce the road crossing influence on sediment transport and deposition, which worked for a while locally until the avulsion developed, which accelerated aggradation in the former main channel above the bridge. Plans have been developed for removing the berm and allowing the stream to re-engage its fan. The key design question presently is: should the berm be excavated to its toe on the channel side to accelerate restoration of depositional processes, or should a semblance of bankfull morphology be retained?

  19. Towards surgeon-authored VR training: the scene-development cycle.

    PubMed

    Dindar, Saleh; Nguyen, Thien; Peters, Jörg

    2016-01-01

    Enabling surgeon-educators to themselves create virtual reality (VR) training units promises greater variety, specialization, and relevance of the units. This paper describes a software bridge that semi-automates the scene-generation cycle, a key bottleneck in authoring, modeling, and developing VR units. Augmenting an open source modeling environment with physical behavior attachment and collision specifications yields single-click testing of the full force-feedback enabled anatomical scene.

  20. Civilian Surge. Key to Complex Operations

    DTIC Science & Technology

    2009-01-01

    being settled, the U.S. Army contributed to building bridges and roads and other construction projects . After World War II, the military focused...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ...of civilians needed to perform such duties as building governments, repairing infrastructure, and opening schools. In both countries, PRTs rely

  1. Bridging the San Francisco System: 21st Century Strategic Partnerships for the Asian Pacific

    DTIC Science & Technology

    2016-04-08

    apparatuses characterized their newly obtained national sovereignty. Further, a union of these disparate and distant archipelagic states in a multilateral...the Nixon administration released the Guam Doctrine in 1969. Later known as the Nixon Doctrine , this policy aimed primarily at Asia, promoted...allies to the North, the archipelagic regional states also continue to offer the United States key regional defense positioning. Moreover, these

  2. The NASA John C. Stennis Environmental Geographic Information System

    NASA Technical Reports Server (NTRS)

    Cohan, Tyrus

    2002-01-01

    Contents include the following: 1. Introduction: Background information. Initial applications of the SSC EGIS. Ongoing projects. 2.Scope of SSC EGIS. 3. Data layers. 4. Onsite operations. 5. Landcover classifications. 6. Current activities. 7. GIS/Key. 8. Infrastructure base map - development. 9. Infrastructure base map - application. 10. Incorrected layer. 11. Corrected layer. 12. Emergency environmental response tool. 13. Future directions. 14. Bridging the gaps. 15. Environmental geographical information system.

  3. Linking Regulation of Practitioner School Psychology and the United Nations Convention on the Rights of the Child: The Need to Build a Bridge

    ERIC Educational Resources Information Center

    Woods, Kevin; Bond, Caroline

    2014-01-01

    In 2014, the 25th anniversary of the United Nations Convention on the Rights of the Child presents an opportunity for school psychology to evaluate its achievements relevant to the Convention, as well as its current and future strategic adherence to the Convention's principles. With analysis of key school psychology documentation from the UK, it…

  4. Crystal Structures of Beta- and Gammaretrovirus Fusion Proteins Reveal a Role for Electrostatic Stapling in Viral Entry

    PubMed Central

    Aydin, Halil; Cook, Jonathan D.

    2014-01-01

    Membrane fusion is a key step in the life cycle of all envelope viruses, but this process is energetically unfavorable; the transmembrane fusion subunit (TM) of the virion-attached glycoprotein actively catalyzes the membrane merger process. Retroviral glycoproteins are the prototypical system to study pH-independent viral entry. In this study, we determined crystal structures of extramembrane regions of the TMs from Mason-Pfizer monkey virus (MPMV) and xenotropic murine leukemia virus-related virus (XMRV) at 1.7-Å and 2.2-Å resolution, respectively. The structures are comprised of a trimer of hairpins that is characteristic of class I viral fusion proteins and now completes a structural library of retroviral fusion proteins. Our results allowed us to identify a series of intra- and interchain electrostatic interactions in the heptad repeat and chain reversal regions. Mutagenesis reveals that charge-neutralizing salt bridge mutations significantly destabilize the postfusion six-helix bundle and abrogate retroviral infection, demonstrating that electrostatic stapling of the fusion subunit is essential for viral entry. Our data indicate that salt bridges are a major stabilizing force on the MPMV and XMRV retroviral TMs and likely provide the key energetics for viral and host membrane fusion. PMID:24131724

  5. Introduction to multiprotocol over ATM (MPOA)

    NASA Astrophysics Data System (ADS)

    Fredette, Andre N.

    1997-10-01

    Multiprotocol over ATM (MPOA) is a new protocol specified by the ATM Forum. MPOA provides a framework for effectively synthesizing bridging and routing with ATM in an environment of diverse protocols and network technologies. The primary goal of MPOA is the efficient transfer of inter-subnet unicast data in a LAN Emulation (LANE) environment. MPOA integrates LANE and the next hop resolution protocol (NHRP) to preserve the benefits of LAN Emulation, while allowing inter-subnet, internetwork layer protocol communication over ATM VCCs without requiring routers in the data path. It reduces latency and the internetwork layer forwarding load on backbone routers by enabling direct connectivity between ATM-attached edge devices (i.e., shortcuts). To establish these shortcuts, MPOA uses both routing and bridging information to locate the edge device closest to the addressed end station. By integrating LANE and NHRP, MPOA allows the physical separation of internetwork layer route calculation and forwarding, a technique known as virtual routing. This separation provides a number of key benefits including enhanced manageability and reduced complexity of internetwork layer capable edge devices. This paper provides an overview of MPOA that summarizes the goals, architecture, and key attributes of the protocol. In presenting this overview, the salient attributes of LANE and NHRP are described as well.

  6. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

    PubMed Central

    Martin, Carol-Anne; Murray, Jennie E.; Carroll, Paula; Leitch, Andrea; Mackenzie, Karen J.; Halachev, Mihail; Fetit, Ahmed E.; Keith, Charlotte; Bicknell, Louise S.; Fluteau, Adeline; Gautier, Philippe; Hall, Emma A.; Joss, Shelagh; Soares, Gabriela; Silva, João; Bober, Michael B.; Duker, Angela; Wise, Carol A.; Quigley, Alan J.; Phadke, Shubha R.; Wood, Andrew J.; Vagnarelli, Paola; Jackson, Andrew P.

    2016-01-01

    Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in NCAPD2, NCAPH, or NCAPD3, encoding subunits of these complexes, cause microcephaly. In addition, hypomorphic Ncaph2 mice have significantly reduced brain size, with frequent anaphase chromatin bridge formation observed in apical neural progenitors during neurogenesis. Such DNA bridges also arise in condensin-deficient patient cells, where they are the consequence of failed sister chromatid disentanglement during chromosome compaction. This results in chromosome segregation errors, leading to micronucleus formation and increased aneuploidy in daughter cells. These findings establish “condensinopathies” as microcephalic disorders, with decatenation failure as an additional disease mechanism for microcephaly, implicating mitotic chromosome condensation as a key process ensuring mammalian cerebral cortex size. PMID:27737959

  7. The research-practice gap: bridging the schism between eating disorder researchers and practitioners.

    PubMed

    Lilienfeld, Scott O; Ritschel, Lorie A; Lynn, Steven Jay; Brown, Amanda P; Cautin, Robin L; Latzman, Robert D

    2013-07-01

    The field of eating disorders (EDs) treatment has been beset by a marked disjunction between scientific evidence and clinical application. We describe the nature and scope of the research-practice gap in the ED field. We draw on surveys and broader literature to better understand the research-practice gap in ED treatment and reasons for resistance to evidence-based practice. We identify three sources of the research-practice gap: (1) attitudinal factors, (2) differences in the definition of "evidence," and (3) cognitive factors, especially naïve realism and confirmation bias. We affirm the role of science as a safeguard against human fallibility and as a means of bridging the research-practice gap, and delineate key principles of scientific thinking for ED researchers and practitioners. We conclude with proposals for narrowing the research-practice gap in ED treatment and enhancing the quality of interventions for ED clients. Copyright © 2013 Wiley Periodicals, Inc.

  8. Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

    NASA Astrophysics Data System (ADS)

    da, Lin-Tai; Pardo-Avila, Fátima; Xu, Liang; Silva, Daniel-Adriano; Zhang, Lu; Gao, Xin; Wang, Dong; Huang, Xuhui

    2016-04-01

    The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. Our results reveal that Pol II backtracking occurs in a stepwise mode where two intermediate states are involved. We find that the continuous bending motion of the Bridge helix (BH) serves as a critical checkpoint, using the highly conserved BH residue T831 as a sensing probe for the 3'-terminal base paring of RNA:DNA hybrid. If the base pair is mismatched, BH bending can promote the RNA 3'-end nucleotide into a frayed state that further leads to the backtracked state. These computational observations are validated by site-directed mutagenesis and transcript cleavage assays, and provide insights into the key factors that regulate the preferences of the backward translocation.

  9. Bridging the gap between hospital and primary care: the pharmacist home visit.

    PubMed

    Ensing, Hendrik T; Koster, Ellen S; Stuijt, Clementine C M; van Dooren, Ad A; Bouvy, Marcel L

    2015-06-01

    Bridging the gap between hospital and primary care is important as transition from one healthcare setting to another increases the risk on drug-related problems and consequent readmissions. To reduce those risks, pharmacist interventions during and after hospitalization have been frequently studied, albeit with variable effects. Therefore, in this manuscript we propose a three phase approach to structurally address post-discharge drug-related problems. First, hospitals need to transfer up-todate medication information to community pharmacists. Second, the key phase of this approach consists of adequate follow-up at the patients' home. Pharmacists need to apply their clinical and communication skills to identify and analyze drug-related problems. Finally, to prevent and solve identified drug related problems a close collaboration within the primary care setting between pharmacists and general practitioners is of utmost importance. It is expected that such an approach results in improved quality of care and improved patient safety.

  10. Modelling of double air-bridged structured inductor implemented by a GaAs integrated passive device manufacturing process

    NASA Astrophysics Data System (ADS)

    Li, Yang; Yao, Zhao; Zhang, Chun-Wei; Fu, Xiao-Qian; Li, Zhi-Ming; Li, Nian-Qiang; Wang, Cong

    2017-05-01

    In order to provide excellent performance and show the development of a complicated structure in a module and system, this paper presents a double air-bridge-structured symmetrical differential inductor based on integrated passive device technology. Corresponding to the proposed complicated structure, a new manufacturing process fabricated on a high-resistivity GaAs substrate is described in detail. Frequency-independent physical models are presented with lump elements and the results of skin effect-based measurements. Finally, some key features of the inductor are compared; good agreement between the measurements and modeled circuit fully verifies the validity of the proposed modeling approach. Meanwhile, we also present a comparison of different coil turns for inductor performance. The proposed work can provide a good solution for the design, fabrication, modeling, and practical application of radio-frequency modules and systems.

  11. Nutrigenetics: bridging two worlds to understand type 2 diabetes.

    PubMed

    Harrington, Janas M; Phillips, Catherine M

    2014-04-01

    The increasing global prevalence of type 2 diabetes mellitus (T2DM) is a major public health concern. Accumulating data provides strong evidence of the shared contribution of genetic and environmental factors to T2DM risk. Genome-wide association studies have hugely improved our understanding of the genetic basis of T2DM. However, it is obvious that genetics only partly account for an individuals' predisposition to T2DM. The dietary environment has changed remarkably over the last century. Examination of individual macronutrients and more recently of foods and dietary patterns is becoming increasingly important in terms of developing public health strategies. Nutrigenetics offers the potential to improve diet-related disease prevention and therapy, but is not without its own challenges. In this review we present evidence on the dietary environment and genetics as risk factors for T2DM and bridging the 2 disciplines we highlight some key gene-nutrient interactions.

  12. Research about the high precision temperature measurement

    NASA Astrophysics Data System (ADS)

    Lin, J.; Yu, J.; Zhu, X.; Zeng, Z.; Deng, Y.

    2012-12-01

    High precision temperature control system is one of most important support conditions for tunable birefringent filter.As the first step,we researched some high precision temperature measurement methods for it. Firstly, circuits with a 24 bit ADC as the sensor's reader were carefully designed; Secondly, an ARM porcessor is used as the centrol processing unit, it provides sufficient reading and procesing ability; Thirdly, three kinds of sensors, PT100, Dale 01T1002-5 thermistor, Wheatstone bridge(constructed by pure copper and manganin) as the senor of the temperature were tested respectively. The resolution of the measurement with these three kinds of sensors are all better than 0.001 that's enough for 0.01 stability temperature control. Comparatively, Dale 01T1002-5 thermistor could get the most accurate temperature of the key point, Wheatstone bridge could get the most accurate mean temperature of the whole layer, both of them will be used in our futrue temperature controll system.

  13. Helping System Engineers Bridge the Peaks

    NASA Technical Reports Server (NTRS)

    Rungta, Neha; Tkachuk, Oksana; Person, Suzette; Biatek, Jason; Whalen, Michael W.; Castle, Joseph; Castle, JosephGundy-Burlet, Karen

    2014-01-01

    In our experience at NASA, system engineers generally follow the Twin Peaks approach when developing safety-critical systems. However, iterations between the peaks require considerable manual, and in some cases duplicate, effort. A significant part of the manual effort stems from the fact that requirements are written in English natural language rather than a formal notation. In this work, we propose an approach that enables system engineers to leverage formal requirements and automated test generation to streamline iterations, effectively "bridging the peaks". The key to the approach is a formal language notation that a) system engineers are comfortable with, b) is supported by a family of automated V&V tools, and c) is semantically rich enough to describe the requirements of interest. We believe the combination of formalizing requirements and providing tool support to automate the iterations will lead to a more efficient Twin Peaks implementation at NASA.

  14. Functional Land Management: Bridging the Think-Do-Gap using a multi-stakeholder science policy interface.

    PubMed

    O'Sullivan, Lilian; Wall, David; Creamer, Rachel; Bampa, Francesca; Schulte, Rogier P O

    2018-03-01

    Functional Land Management (FLM) is proposed as an integrator for sustainability policies and assesses the functional capacity of the soil and land to deliver primary productivity, water purification and regulation, carbon cycling and storage, habitat for biodiversity and recycling of nutrients. This paper presents the catchment challenge as a method to bridge the gap between science, stakeholders and policy for the effective management of soils to deliver these functions. Two challenges were completed by a wide range of stakeholders focused around a physical catchment model-(1) to design an optimised catchment based on soil function targets, (2) identify gaps to implementation of the proposed design. In challenge 1, a high level of consensus between different stakeholders emerged on soil and management measures to be implemented to achieve soil function targets. Key gaps including knowledge, a mix of market and voluntary incentives and mandatory measures were identified in challenge 2.

  15. A security proof of the round-robin differential phase shift quantum key distribution protocol based on the signal disturbance

    NASA Astrophysics Data System (ADS)

    Sasaki, Toshihiko; Koashi, Masato

    2017-06-01

    The round-robin differential phase shift (RRDPS) quantum key distribution (QKD) protocol is a unique QKD protocol whose security has not been understood through an information-disturbance trade-off relation, and a sufficient amount of privacy amplification was given independently of signal disturbance. Here, we discuss the security of the RRDPS protocol in the asymptotic regime when a good estimate of the bit error rate is available as a measure of signal disturbance. The uniqueness of the RRDPS protocol shows up as a peculiar form of information-disturbance trade-off curve. When the length of a block of pulses used for encoding and the signal disturbance are both small, it provides a significantly better key rate than that from the original security proof. On the other hand, when the block length is large, the use of the signal disturbance makes little improvement in the key rate. Our analysis will bridge a gap between the RRDPS protocol and the conventional QKD protocols.

  16. Putting the RSTA O&O to the Test: Burma 2004

    DTIC Science & Technology

    2001-05-01

    operations with three international airports (Bangkok, Chiang Mai and Hat Yai), numerous shipping ports, and an efficient railway. However, there are...interaction with the indigenous population. The urban areas (see Appendix C – Urban Maps) in this AOR include: • Chiang Mai , the third largest city in...The eight bridges connecting the two halves are key terrain. Burmese insurgents have moved into the border areas west of Chiang Mai . In response

  17. Translations on Eastern Europe Political, Sociological, and Military Affairs, Number 1366

    DTIC Science & Technology

    1977-03-18

    Key Words and Document Analysis. 17a. Descriptors X X X X X X International Affairs Albania Bulgaria Czechoslovakia East Germany Hungary...TRIBUNA, 29 Dec 76) ’ 11 EAST GERMANY GDR Military Developments Reported (DIE WELT, various dates) 16 Figures on Military...34 conquered Tirgoviste and Giurgiu where "the enemy hit like turbined pigs, destroying the bridge and drowning the Moslems." The author goes on to quote from

  18. Science communication at scientific societies.

    PubMed

    Braha, Jeanne

    2017-10-01

    Scientific societies can play a key role in bridging the research and practice of scientists' engagement of public audiences. Societies are beginning to support translation of science communication research, connections between scientists and audiences, and the creation of opportunities for scientists to engage publics without extensive customization. This article suggests roles, strategies, and mechanisms for scientific societies to promote and enhance their member's engagement of public audiences. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Triadic awareness predicts partner choice in male-infant-male interactions in Barbary macaques.

    PubMed

    Kubenova, Barbora; Konecna, Martina; Majolo, Bonaventura; Smilauer, Petr; Ostner, Julia; Schülke, Oliver

    2017-03-01

    Social knowledge beyond one's direct relationships is a key in successfully manoeuvring the social world. Individuals gather information on the quality of social relationships between their group companions, which has been termed triadic awareness. Evidence of the use of triadic awareness in natural contexts is limited mainly to conflict management. Here we investigated triadic awareness in wild Barbary macaques (Macaca sylvanus) in the context of bridging interactions defined as male-infant-male interactions whereby a male (initiator, holder) presents an infant to another male (receiver, non-holder) in order to initiate an affiliative interaction with that male. Analyses based on 1263 h of focal observations on ten infants of one wild social group in Morocco supported the hypothesis that males use their knowledge of the relationship between infants and other adult males when choosing a male as a partner for bridging interactions. Specifically, (i) the number of bridging interactions among holder-infant-receiver triads was positively affected by the strength of the infant-receiver relationship and (ii) when two males were available as bridging partners, a male was more likely to be chosen as the receiver the stronger his social relationship with the infant relative to the other available male. This demonstrates that non-human primates establish triadic awareness of temporary infant-male relationships and use it in a naturally occurring affiliative context. Our results contribute to the discussion about the mechanism underlying the acquisition of triadic awareness and the benefits of its usage, and lend support to hypotheses linking social complexity to the evolution of complex cognition.

  20. Bridging the gap: decision-making processes of women with breast cancer using complementary and alternative medicine (CAM).

    PubMed

    Balneaves, Lynda G; Truant, Tracy L O; Kelly, Mary; Verhoef, Marja J; Davison, B Joyce

    2007-08-01

    The purpose of this study was to explore the personal and social processes women with breast cancer engaged in when making decisions about complementary and alternative medicine (CAM). The overall aim was to develop a conceptual model of the treatment decision-making process specific to breast cancer care and CAM that will inform future information and decision support strategies. Grounded theory methodology explored the decisions of women with breast cancer using CAM. Semistructured interviews were conducted with 20 women diagnosed with early-stage breast cancer. Following open, axial, and selective coding, the constant comparative method was used to identify key themes in the data and develop a conceptual model of the CAM decision-making process. The final decision-making model, Bridging the Gap, was comprised of four core concepts including maximizing choices/minimizing risks, experiencing conflict, gathering and filtering information, and bridging the gap. Women with breast cancer used one of three decision-making styles to address the paradigmatic, informational, and role conflict they experienced as a result of the gap they perceived between conventional care and CAM: (1) taking it one step at a time, (2) playing it safe, and (3) bringing it all together. Women with breast cancer face conflict and anxiety when making decisions about CAM within a conventional cancer care context. Information and decision support strategies are needed to ensure women are making safe, informed treatment decisions about CAM. The model, Bridging the Gap, provides a conceptual framework for future decision support interventions.

  1. Agri-environmental collaboratives as bridging organisations in landscape management.

    PubMed

    Prager, Katrin

    2015-09-15

    In recent years, landscape and its management has become a focus of policies and academic conceptualisation. Landscape is understood as a concept of interconnected natural and human systems. Its management must take into account the dynamic interdependencies and diverging interests of various stakeholders at different levels. Bridging organisations can provide an arena for trust-building, conflict resolution, learning and collaboration between relevant stakeholders. This paper draws on two strands of literature - landscape governance and co-management of social-ecological systems - to investigate the contributions of agri-environmental collaboratives (AEC) to sustainable landscape management. Based on data from 41 interviews with key informants and AEC members in Germany and the Netherlands, six fields of contributions were identified: policy implementation and service provision; coordination and mediation; awareness raising and behaviour change; care for 'everyday' landscapes; maintenance and protection of landscapes (including species and habitats); and income generation and economic benefits. Some of the contributions evolve around the specific role of AEC as bridging organisations, but other contributions such as economic benefits emerge beyond this analytical lens. The paper therefore emphasises holistic, bottom up assessment of AEC contributions and argues that governments should support such organisations through i) funding for facilitators and ii) funding for impact monitoring and data management. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Network approach to the symptom-level association between alcohol use disorder and posttraumatic stress disorder.

    PubMed

    Afzali, Mohammad H; Sunderland, Matthew; Batterham, Philip J; Carragher, Natacha; Calear, Alison; Slade, Tim

    2017-03-01

    The high prevalence of alcohol use disorder among individuals with a history of trauma and posttraumatic stress disorder is well documented. The current study applied network analysis to map the structure of symptom associations between these disorders. Data come from a community sample of 449 Australian adults with a history of trauma and alcohol consumption during the last 12 months. Data analysis consisted of the construction of the comorbidity network of PTSD/AUD symptoms, identification of the bridging symptoms, computation of the centrality measures, and evaluation of the robustness of the results. Results highlighted two main symptom clusters, corresponding to two disorders, and that only nine edges connected the two clusters. Bridging symptoms connecting the two clusters were: alcohol use in dangerous situations, physical or mental health problems as a result of alcohol use, loss of interest or reduced social activities, and reckless/self-destructive behaviour. Identification of both central symptoms, because of their key role in the constellation and strong associations with majority of symptoms, and bridge symptoms, because of their mediating role between two disorders, has some implications in terms of self-medication and risk-taking/self-regulation theories of comorbidity and provides a number of clinical implications, which warrants further exploration within clinical samples.

  3. Silk elasticity as a potential constraint on spider body size.

    PubMed

    Rodríguez-Gironés, Miguel A; Corcobado, Guadalupe; Moya-Laraño, Jordi

    2010-10-07

    Silk is known for its strength and extensibility and has played a key role in the radiation of spiders. Individual spiders use different glands to produce silk types with unique sets of proteins. Most research has studied the properties of major ampullate and capture spiral silks and their ecological implications, while little is known about minor ampullate silk, the type used by those spider species studied to date for bridging displacements. A biomechanical model parameterised with available data shows that the minimum radius of silk filaments required for efficient bridging grows with the square root of the spider's body mass, faster than the radius of minor ampullate silk filaments actually produced by spiders. Because the morphology of spiders adapted to walking along or under silk threads is ill suited for moving on a solid surface, for these species there is a negative relationship between body mass and displacement ability. As it stands, the model suggests that spiders that use silk for their displacements are prevented from attaining a large body size if they must track their resources in space. In particular, silk elasticity would favour sexual size dimorphism because males that must use bridging lines to search for females cannot grow large. 2010 Elsevier Ltd. All rights reserved.

  4. Effect of sodium chloride on the structure and stability of spider silk's N-terminal protein domain.

    PubMed

    Gronau, Greta; Qin, Zhao; Buehler, Markus J

    2013-03-01

    A spider's ability to store silk protein solutions at high concentration is believed to be related to the protein's terminal domains. It has been suggested that a shift in salt concentration and pH can have a significant influence on the assembly process. Based on experimental data, a model has been proposed in which the N-terminal domain exists as a monomer during storage and assembles into a homodimer upon spinning. Here we perform a systematic computational study using atomistic, coarse-grained and well-tempered metadynamics simulation to understand how the NaCl concentration in the solution affects the N-terminal domain of the silk protein. Our results show that a high salt concentration, as found during storage, weakens key salt bridges between the monomers, inducing a loss in bond energy by 28.6% in a single salt bridge. As a result dimer formation is less likely as 35.5% less energy is required to unfold the dimer by mechanical force. Conversely, homodimer formation appears to be more likely at low salt concentrations as the salt bridge stays at the lower energy state. The link between salt concentration, structure and stability of the N-terminal domain provides a possible mechanism that prevents premature fiber formation during storage.

  5. Effect of sodium chloride on the structure and stability of spider silk’s N-terminal protein domain

    PubMed Central

    Gronau, Greta; Qin, Zhao; Buehler, Markus J.

    2013-01-01

    A spider’s ability to store silk protein solutions at high concentration is believed to be related to the protein’s terminal domains. It has been suggested that a shift in salt concentration and pH can have a significant influence on the assembly process. Based on experimental data, a model has been proposed in which the N-terminal domain exists as a monomer during storage and assembles into a homodimer upon spinning. Here we perform a systematic computational study using atomistic, coarse-grained and well-tempered metadynamics simulation to understand how the NaCl concentration in the solution affects the N-terminal domain of the silk protein. Our results show that a high salt concentration, as found during storage, weakens key salt bridges between the monomers, inducing a loss in bond energy by 28.6% in a single salt bridge. As a result dimer formation is less likely as 35.5% less energy is required to unfold the dimer by mechanical force. Conversely, homodimer formation appears to be more likely at low salt concentrations as the salt bridge stays at the lower energy state. The link between salt concentration, structure and stability of the N-terminal domain provides a possible mechanism that prevents premature fiber formation during storage. PMID:23833703

  6. Formation of a cylindrical bridge in cell division

    NASA Astrophysics Data System (ADS)

    Citron, Daniel; Schmidt, Laura E.; Reichl, Elizabeth; Ren, Yixin; Robinson, Douglas; Zhang, Wendy W.

    2007-11-01

    In nature, the shape transition associated with the division of a mother cell into two daughter cells proceeds via a variety of routes. In the cylinder-thinning route, which has been observed in Dictyostelium and most animal cells, the mother cell first forms a broad bridge-like region, also known as a furrow, between two daughter cells. The furrow then rapidly evolves into a cylindrical bridge, which thins and eventually severs the mother cell into two. The fundamental mechanism underlying this division route is not understood. Recent experiments on Dictyostelium found that, while the cylinder-thinning route persists even when key actin cross-linking proteins are missing, it is disrupted by the removal of force-generating myosin-II proteins. Other measurements revealed that mutant cells lacking myosin-II have a much more uniform tension over the cell surface than wild-type cells. This suggests that tension variation may be important. Here we use a fluid model, previously shown to reproduce the thinning dynamics [Zhang & Robinson, PNAS 102, 7186 (2005)], to test this idea. Consistent with the experiments, the model shows that the cylinder formation process occurs regardless of the exact viscoelastic properties of the cell. In contrast to the experiments, a tension variation in the model hinders, rather then expedites, the cylinder formation.

  7. A bridge column with superelastic NiTi SMA and replaceable rubber hinge for earthquake damage mitigation

    NASA Astrophysics Data System (ADS)

    Varela, Sebastian; ‘Saiid' Saiidi, M.

    2016-07-01

    This paper reports a unique concept for resilient bridge columns that can undergo intense earthquake loading and remain functional with minimal damage and residual drift. In this concept, the column is designed so that its components can be easily disassembled and reassembled to facilitate material recycling and component reuse. This is meant to foster sustainability of bridge systems while minimizing monetary losses from earthquakes. Self-centering and energy dissipation in the column were provided by unbonded superelastic nickel-titanium (NiTi) shape memory alloy bars placed inside a plastic hinge element made of rubber. This replaceable plastic hinge was in turn attached to a concrete-filled carbon fiber-reinforced polymer tube and a precast concrete footing that were designed to behave elastically. The proposed concept was evaluated experimentally by testing a ¼-scale column model under simulated near-fault earthquake motions on a shake table. After testing, the model was disassembled, reassembled and tested again. The seismic performance of the reassembled model was found to be comparable to that of the ‘virgin’ model. A relatively simple computational model of the column tested that was developed in OpenSees was able to match some of the key experimental response parameters.

  8. Examining key design decisions involved in developing a serious game for child sexual abuse prevention.

    PubMed

    Stieler-Hunt, Colleen; Jones, Christian M; Rolfe, Ben; Pozzebon, Kay

    2014-01-01

    This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitizing game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has implications for the design of Serious Games more generally, including that research should underpin game design decisions, game designers should consider ways of bridging the game to real life, the learning that arises from the game should go beyond rote-learning, designers should consider how the player can make the game-world their own and comprehensive evaluations of Serious Games should be undertaken.

  9. Biometrics encryption combining palmprint with two-layer error correction codes

    NASA Astrophysics Data System (ADS)

    Li, Hengjian; Qiu, Jian; Dong, Jiwen; Feng, Guang

    2017-07-01

    To bridge the gap between the fuzziness of biometrics and the exactitude of cryptography, based on combining palmprint with two-layer error correction codes, a novel biometrics encryption method is proposed. Firstly, the randomly generated original keys are encoded by convolutional and cyclic two-layer coding. The first layer uses a convolution code to correct burst errors. The second layer uses cyclic code to correct random errors. Then, the palmprint features are extracted from the palmprint images. Next, they are fused together by XORing operation. The information is stored in a smart card. Finally, the original keys extraction process is the information in the smart card XOR the user's palmprint features and then decoded with convolutional and cyclic two-layer code. The experimental results and security analysis show that it can recover the original keys completely. The proposed method is more secure than a single password factor, and has higher accuracy than a single biometric factor.

  10. Examining key design decisions involved in developing a serious game for child sexual abuse prevention

    PubMed Central

    Stieler-Hunt, Colleen; Jones, Christian M.; Rolfe, Ben; Pozzebon, Kay

    2014-01-01

    This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitizing game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has implications for the design of Serious Games more generally, including that research should underpin game design decisions, game designers should consider ways of bridging the game to real life, the learning that arises from the game should go beyond rote-learning, designers should consider how the player can make the game-world their own and comprehensive evaluations of Serious Games should be undertaken. PMID:24550880

  11. Prediction of Scour Depth around Bridge Piers using Adaptive Neuro-Fuzzy Inference Systems (ANFIS)

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Zhang, Hanqing

    2014-05-01

    Earth's surface is continuously shaped due to the action of geophysical flows. Erosion due to the flow of water in river systems has been identified as a key problem in preserving ecological health of river systems but also a threat to our built environment and critical infrastructure, worldwide. As an example, it has been estimated that a major reason for bridge failure is due to scour. Even though the flow past bridge piers has been investigated both experimentally and numerically, and the mechanisms of scouring are relatively understood, there still lacks a tool that can offer fast and reliable predictions. Most of the existing formulas for prediction of bridge pier scour depth are empirical in nature, based on a limited range of data or for piers of specific shape. In this work, the application of a Machine Learning model that has been successfully employed in Water Engineering, namely an Adaptive Neuro-Fuzzy Inference System (ANFIS) is proposed to estimate the scour depth around bridge piers. In particular, various complexity architectures are sequentially built, in order to identify the optimal for scour depth predictions, using appropriate training and validation subsets obtained from the USGS database (and pre-processed to remove incomplete records). The model has five variables, namely the effective pier width (b), the approach velocity (v), the approach depth (y), the mean grain diameter (D50) and the skew to flow. Simulations are conducted with data groups (bed material type, pier type and shape) and different number of input variables, to produce reduced complexity and easily interpretable models. Analysis and comparison of the results indicate that the developed ANFIS model has high accuracy and outstanding generalization ability for prediction of scour parameters. The effective pier width (as opposed to skew to flow) is amongst the most relevant input parameters for the estimation.

  12. In Situ Repair of Deteriorated Concrete in Hydraulic Structures: Feasibility Study

    DTIC Science & Technology

    1987-05-01

    because of its severe deterioration. Examination of the structure had revealed extensive cracking in the beams , columns , and walls as well as pockets of...used extensively in hydraulic structures, such as dams, spill- ways, lock chambers, and bridge support columns and piers. The Corps of Engineers...Figure 6. Repair of crack by post reinforcement. lli FORM KEY WITH PRECAST CONCRETE OR MORTAR PLUGS SET IN BITI.MEN, HoLE DRILLED IN STEM OF WALL

  13. Bridging the Gap: Developing a Tool to Support Local Civilian and Military Disaster Preparedness

    DTIC Science & Technology

    2010-01-01

    HSC, 2005), the National Strategy for Physical Protection of Critical Infrastructures and Key Assets (DHS, 2003b), the National Strategy for Mari- time...10-2501 (p. 46), The installation CEMP 10-2 provides comprehensive guidance for emergency response to physical threats resulting from major accidents...installations must develop a CEMP 10-2 using the AF [Air Force] template to address the physical threats to their base. . . . The CEMP 10-2 should be

  14. Plasma contactor design for electrodynamic tether applications

    NASA Technical Reports Server (NTRS)

    Wilbur, Paul J.; Laupa, Thomas G.

    1988-01-01

    The plasma contacting process is described and experiments are discussed that suggest the key role that cold ions play in establishing a low impedance plasma bridge that can conduct current in either direction between a contactor electrode and a dilute plasma. A ring cusp contactor is shown to provide from 1000-mA of electron emission to 500-mA of electron collection as its bias relative to a simulated space plasma is varied through an 80-v range.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martz, Joseph Christopher; Spearing, Dane Robert; Labouriau, Andrea

    Microclad is a composite material consisting of a thin copper coating applied on a single side over a Kapton substrate. Kapton is the commercial designator for polyimide supplied by DuPont. Microclad is a key material in detonator manufacture and function. Detonators which utilize Microclad function when a large current applied through a thin bridge etched into the copper produces a plasma, accelerating a Kapton flyer into an explosive (PETN) pellet. The geometry and properties of the Microclad are a critical element of this process.

  16. Experimental design to measure the anchoring energy on substrate surface by using the alternating-current bridge

    NASA Astrophysics Data System (ADS)

    Hao, Hui-Ming; Liu, Yao-Yao; Zhang, Ping; Cai, Ming-Lei; Wang, Xiao-Yan; Zhu, Ji-Liang; Ye, Wen-Jiang

    2017-08-01

    Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 11374087 and 11504080), the Natural Science Foundation of Hebei Province, China (Grant Nos. A2014202123 and A2017202004), the Research Project of the Education Department of Hebei Province, China (Grant No. QN2014130), the Key Subject Construction Project of Hebei Provincial University, and the Undergraduate Innovation and Entrepreneurship Training Program, China (Grant No. 201610080016).

  17. Network news: innovations in 21st century systems biology.

    PubMed

    Arkin, Adam P; Schaffer, David V

    2011-03-18

    A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approaches bridge the gap between correlative analysis and mechanistic insights? Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Effect of Context on Internal and External Actor’s Perception on COIN

    DTIC Science & Technology

    2011-05-19

    beautiful mountain ranges, tourism industry and expansive fruit orchards along the Swat River has been a cradle of civilization since the third century BC...execute, created a class system in Swat consisting of a few privileged rich landowners, Khans, and the majority of poor farmers and peasants. The Wali...key bridges and culverts that not only affected military convoys, but also the local farmers and traders whose goods could not be brought to the

  19. Incorporating physically-based microstructures in materials modeling: Bridging phase field and crystal plasticity frameworks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lim, Hojun; Abdeljawad, Fadi; Owen, Steven J.

    Here, the mechanical properties of materials systems are highly influenced by various features at the microstructural level. The ability to capture these heterogeneities and incorporate them into continuum-scale frameworks of the deformation behavior is considered a key step in the development of complex non-local models of failure. In this study, we present a modeling framework that incorporates physically-based realizations of polycrystalline aggregates from a phase field (PF) model into a crystal plasticity finite element (CP-FE) framework. Simulated annealing via the PF model yields ensembles of materials microstructures with various grain sizes and shapes. With the aid of a novel FEmore » meshing technique, FE discretizations of these microstructures are generated, where several key features, such as conformity to interfaces, and triple junction angles, are preserved. The discretizations are then used in the CP-FE framework to simulate the mechanical response of polycrystalline α-iron. It is shown that the conformal discretization across interfaces reduces artificial stress localization commonly observed in non-conformal FE discretizations. The work presented herein is a first step towards incorporating physically-based microstructures in lieu of the overly simplified representations that are commonly used. In broader terms, the proposed framework provides future avenues to explore bridging models of materials processes, e.g. additive manufacturing and microstructure evolution of multi-phase multi-component systems, into continuum-scale frameworks of the mechanical properties.« less

  20. Mechanism of conformational coupling in SecA: Key role of hydrogen-bonding networks and water interactions.

    PubMed

    Milenkovic, Stefan; Bondar, Ana-Nicoleta

    2016-02-01

    SecA uses the energy yielded by the binding and hydrolysis of adenosine triphosphate (ATP) to push secretory pre-proteins across the plasma membrane in bacteria. Hydrolysis of ATP occurs at the nucleotide-binding site, which contains the conserved carboxylate groups of the DEAD-box helicases. Although crystal structures provide valuable snapshots of SecA along its reaction cycle, the mechanism that ensures conformational coupling between the nucleotide-binding site and the other domains of SecA remains unclear. The observation that SecA contains numerous hydrogen-bonding groups raises important questions about the role of hydrogen-bonding networks and hydrogen-bond dynamics in long-distance conformational couplings. To address these questions, we explored the molecular dynamics of SecA from three different organisms, with and without bound nucleotide, in water. By computing two-dimensional hydrogen-bonding maps we identify networks of hydrogen bonds that connect the nucleotide-binding site to remote regions of the protein, and sites in the protein that respond to specific perturbations. We find that the nucleotide-binding site of ADP-bound SecA has a preferred geometry whereby the first two carboxylates of the DEAD motif bridge via hydrogen-bonding water. Simulations of a mutant with perturbed ATP hydrolysis highlight the water-bridged geometry as a key structural element of the reaction path. Copyright © 2015. Published by Elsevier B.V.

  1. Prototypes for Content-Based Image Retrieval in Clinical Practice

    PubMed Central

    Depeursinge, Adrien; Fischer, Benedikt; Müller, Henning; Deserno, Thomas M

    2011-01-01

    Content-based image retrieval (CBIR) has been proposed as key technology for computer-aided diagnostics (CAD). This paper reviews the state of the art and future challenges in CBIR for CAD applied to clinical practice. We define applicability to clinical practice by having recently demonstrated the CBIR system on one of the CAD demonstration workshops held at international conferences, such as SPIE Medical Imaging, CARS, SIIM, RSNA, and IEEE ISBI. From 2009 to 2011, the programs of CADdemo@CARS and the CAD Demonstration Workshop at SPIE Medical Imaging were sought for the key word “retrieval” in the title. The systems identified were analyzed and compared according to the hierarchy of gaps for CBIR systems. In total, 70 software demonstrations were analyzed. 5 systems were identified meeting the criterions. The fields of application are (i) bone age assessment, (ii) bone fractures, (iii) interstitial lung diseases, and (iv) mammography. Bridging the particular gaps of semantics, feature extraction, feature structure, and evaluation have been addressed most frequently. In specific application domains, CBIR technology is available for clinical practice. While system development has mainly focused on bridging content and feature gaps, performance and usability have become increasingly important. The evaluation must be based on a larger set of reference data, and workflow integration must be achieved before CBIR-CAD is really established in clinical practice. PMID:21892374

  2. Incorporating physically-based microstructures in materials modeling: Bridging phase field and crystal plasticity frameworks

    DOE PAGES

    Lim, Hojun; Abdeljawad, Fadi; Owen, Steven J.; ...

    2016-04-25

    Here, the mechanical properties of materials systems are highly influenced by various features at the microstructural level. The ability to capture these heterogeneities and incorporate them into continuum-scale frameworks of the deformation behavior is considered a key step in the development of complex non-local models of failure. In this study, we present a modeling framework that incorporates physically-based realizations of polycrystalline aggregates from a phase field (PF) model into a crystal plasticity finite element (CP-FE) framework. Simulated annealing via the PF model yields ensembles of materials microstructures with various grain sizes and shapes. With the aid of a novel FEmore » meshing technique, FE discretizations of these microstructures are generated, where several key features, such as conformity to interfaces, and triple junction angles, are preserved. The discretizations are then used in the CP-FE framework to simulate the mechanical response of polycrystalline α-iron. It is shown that the conformal discretization across interfaces reduces artificial stress localization commonly observed in non-conformal FE discretizations. The work presented herein is a first step towards incorporating physically-based microstructures in lieu of the overly simplified representations that are commonly used. In broader terms, the proposed framework provides future avenues to explore bridging models of materials processes, e.g. additive manufacturing and microstructure evolution of multi-phase multi-component systems, into continuum-scale frameworks of the mechanical properties.« less

  3. Bridging Scales: A Model-Based Assessment of the Technical Tidal-Stream Energy Resource off Massachusetts, USA

    NASA Astrophysics Data System (ADS)

    Cowles, G. W.; Hakim, A.; Churchill, J. H.

    2016-02-01

    Tidal in-stream energy conversion (TISEC) facilities provide a highly predictable and dependable source of energy. Given the economic and social incentives to migrate towards renewable energy sources there has been tremendous interest in the technology. Key challenges to the design process stem from the wide range of problem scales extending from device to array. In the present approach we apply a multi-model approach to bridge the scales of interest and select optimal device geometries to estimate the technical resource for several realistic sites in the coastal waters of Massachusetts, USA. The approach links two computational models. To establish flow conditions at site scales ( 10m), a barotropic setup of the unstructured grid ocean model FVCOM is employed. The model is validated using shipboard and fixed ADCP as well as pressure data. For device scale, the structured multiblock flow solver SUmb is selected. A large ensemble of simulations of 2D cross-flow tidal turbines is used to construct a surrogate design model. The surrogate model is then queried using velocity profiles extracted from the tidal model to determine the optimal geometry for the conditions at each site. After device selection, the annual technical yield of the array is evaluated with FVCOM using a linear momentum actuator disk approach to model the turbines. Results for several key Massachusetts sites including comparison with theoretical approaches will be presented.

  4. Development of an intelligent hydroinformatic system for real-time monitoring and assessment of civil infrastructure

    NASA Astrophysics Data System (ADS)

    Cahill, Paul; Michalis, Panagiotis; Solman, Hrvoje; Kerin, Igor; Bekic, Damir; Pakrashi, Vikram; McKeogh, Eamon

    2017-04-01

    With the effects of climate change becoming more apparent, extreme weather events are now occurring with greater frequency throughout the world. Such extreme events have resulted in increased high intensity flood events which are having devastating consequences on hydro-structures, especially on bridge infrastructure. The remote and often inaccessible nature of such bridges makes inspections problematic, a major concern if safety assessments are required during and after extreme flood events. A solution to this is the introduction of smart, low cost sensing solutions at locations susceptible to hydro-hazards. Such solutions can provide real-time information on the health of the bridge and its environments, with such information aiding in the mitigation of the risks associated with extreme weather events. This study presents the development of an intelligent system for remote, real-time monitoring of hydro-hazards to bridge infrastructure. The solution consists of two types of remote monitoring stations which have the capacity to monitor environmental conditions and provide real-time information to a centralized, big data database solution, from which an intelligent decision support system will accommodate the results to control and manage bridge, river and catchment assets. The first device developed as part of the system is the Weather Information Logging Device (WILD), which monitors rainfall, temperature and air and soil moisture content. The ability of the WILD to monitor rainfall in real time enables flood early warning alerts and predictive river flow conditions, thereby enabling decision makers the ability to make timely and effective decisions about critical infrastructures in advance of extreme flood events. The WILD is complemented by a second monitoring device, the Bridge Information Recording Device (BIRD), which monitors water levels at a given location in real-time. The monitoring of water levels of a river allows for, among other applications, hydraulic modelling to assess the likely impact that severe flood events will have on a bridges foundation, particularly due to scour. The process of reading and validating data from the WILD and BIRD buffer servers is outlined, as is the transmission protocol used for the sending of recorded data to a centralized repository for further use and analysis. Finally, the development of a centralized repository for the collection of data from the WILD and BIRD devices is presented. Eventually the big data solution would be used to receive, store and send the monitored data to the hydrological models, whether existing or developed, and the results would be transmitted to the intelligent decision support system based on a web-based platform, for managing, planning and executing data, processes and procedures for bridge assets. The development of intelligent hydroinformatic system is an important tool for the protection of key infrastructure assets from the increasingly common effects of climate change. Acknowledgement The authors wish to acknowledge the financial support of the European Commission, through the Marie Curie Industry-Academia Partnership and Pathways Network BRIDGE SMS (Intelligent Bridge Assessment Maintenance and Management System) - FP7-People-2013-IAPP- 612517.

  5. Thermo-optic characteristics and switching power limit of slow-light photonic crystal structures on a silicon-on-insulator platform.

    PubMed

    Chahal, Manjit; Celler, George K; Jaluria, Yogesh; Jiang, Wei

    2012-02-13

    Employing a semi-analytic approach, we study the influence of key structural and optical parameters on the thermo-optic characteristics of photonic crystal waveguide (PCW) structures on a silicon-on-insulator (SOI) platform. The power consumption and spatial temperature profile of such structures are given as explicit functions of various structural, thermal and optical parameters, offering physical insight not available in finite-element simulations. Agreement with finite-element simulations and experiments is demonstrated. Thermal enhancement of the air-bridge structure is analyzed. The practical limit of thermo-optic switching power in slow light PCWs is discussed, and the scaling with key parameters is analyzed. Optical switching with sub-milliwatt power is shown viable.

  6. Quantum key distribution with untrusted detectors

    NASA Astrophysics Data System (ADS)

    González, P.; Rebón, L.; Ferreira da Silva, T.; Figueroa, M.; Saavedra, C.; Curty, M.; Lima, G.; Xavier, G. B.; Nogueira, W. A. T.

    2015-08-01

    Side-channel attacks currently constitute the main challenge for quantum key distribution (QKD) to bridge theory with practice. So far two main approaches have been introduced to address this problem, (full) device-independent QKD and measurement-device-independent QKD. Here we present a third solution that might exceed the performance and practicality of the previous two in circumventing detector side-channel attacks, which arguably is the most hazardous part of QKD implementations. Our proposal has, however, one main requirement: the legitimate users of the system need to ensure that their labs do not leak any unwanted information to the outside. The security in the low-loss regime is guaranteed, while in the high-loss regime we already prove its robustness against some eavesdropping strategies.

  7. Operation IceBridge Turns Five

    NASA Image and Video Library

    2017-12-08

    In May 2014, two new studies concluded that a section of the land-based West Antarctic ice sheet had reached a point of inevitable collapse. Meanwhile, fresh observations from September 2014 showed sea ice around Antarctica had reached its greatest extent since the late 1970s. To better understand such dynamic and dramatic differences in the region's land and sea ice, researchers are travelling south to Antarctica this month for the sixth campaign of NASA’s Operation IceBridge. The airborne campaign, which also flies each year over Greenland, makes annual surveys of the ice with instrumented research aircraft. Instruments range from lasers that map the elevation of the ice surface, radars that "see" below it, and downward looking cameras to provide a natural-color perspective. The Digital Mapping System (DMS) camera acquired the above photo during the mission’s first science flight on October 16, 2009. At the time of the image, the DC-8 aircraft was flying at an altitude of 515 meters (1,700 feet) over heavily compacted first-year sea ice along the edge of the Amundsen Sea. Since that first flight, much has been gleaned from IceBridge data. For example, images from an IceBridge flight in October 2011 revealed a massive crack running about 29 kilometers (18 miles) across the floating tongue of Antarctica's Pine Island Glacier. The crack ultimately led to a 725-square-kilometer (280-square-mile) iceberg. In 2012, IceBridge data was a key part of a new map of Antarctica called Bedmap2. By combining surface elevation, ice thickness, and bedrock topography, Bedmap2 gives a clearer picture of Antarctica from the ice surface down to the land surface. Discoveries have been made in Greenland, too, including the identification of a 740-kilometer-long (460-mile-long) mega canyon below the ice sheet. Repeated measurements of land and sea ice from aircraft extend the record of observations once made by NASA’s Ice, Cloud, and Land Elevation Satellite, or ICESat, which stopped functioning in 2009. In addition to extending the ICESat record, IceBridge also sets the stage for ICESat-2, which is scheduled for launch in 2017. Credit: IceBridge DMS L0 Raw Imagery courtesy of the Digital Mapping System (DMS) team/NASA DAAC at the National Snow and Ice Data Center More info: earthobservatory.nasa.gov/IOTD/view.php?id=84549 earthobservatory.nasa.gov/IOTD/view.php?id=84549

  8. Thermodynamics, ecology and evolutionary biology: A bridge over troubled water or common ground?

    NASA Astrophysics Data System (ADS)

    Skene, Keith R.

    2017-11-01

    This paper addresses a key issue confronting ecological and evolutionary biology, namely the challenge of a cohesive approach to these fields given significant differences in the concepts and foundations of their study. Yet these two areas of scientific research are paramount in terms addressing the spatial and temporal dynamics and distribution of diversity, an understanding of which is needed if we are to resolve the current crisis facing the biosphere. The importance of understanding how nature responds to change is now of essential rather than of metaphysical interest as our planet struggles with increasing anthropogenic damage. Ecology and evolutionary biology can no longer remain disjointed. While some progress has been made in terms of synthetic thinking across these areas, this has often been in terms of bridge building, where thinking in one aspect is extended over to the other side. We review these bridges and the success or otherwise of such efforts. This paper then suggests that in order to move from a descriptive to a mechanistic understanding of the biosphere, we may need to re-evaluate our approach to the studies of ecology and evolutionary biology, finding a common denominator that will enable us to address the critical issues facing us, particularly in terms of understanding what drives change, what determines tempo and how communities function. Common ground, we argue, is essential if we are to comprehend how resilience operates in the natural world and how diversification can counter increasing extinction rates. This paper suggests that thermodynamics may provide a bridge between ecology and evolutionary biology, and that this will enable us to move forward with otherwise intractable problems.

  9. Post-glacial flooding of the Bering Land Bridge dated to 11 cal ka BP based on new geophysical and sediment records

    USGS Publications Warehouse

    Jakobsson, Martin; Pearce, Christof; Cronin, Thomas M.; Backman, Jan; Anderson, Leif G.; Barrientos, Natalia; Bjork, Goran; Coxhall, Helen; de Boer, Agatha; Mayer, Larry; Morth, Carl-Magnus; Nilsson, Johan; Rattray, Jayne; Sranne, Christian; Semiletov, Igor; O'Regan, Matt

    2017-01-01

    The Bering Strait connects the Arctic and Pacific oceans and separates the North American and Asian landmasses. The presently shallow ( ∼  53 m) strait was exposed during the sea level lowstand of the last glacial period, which permitted human migration across a land bridge today referred to as the Bering Land Bridge. Proxy studies (stable isotope composition of foraminifera, whale migration into the Arctic Ocean, mollusc and insect fossils and paleobotanical data) have suggested a range of ages for the Bering Strait reopening, mainly falling within the Younger Dryas stadial (12.9–11.7 cal ka BP). Here we provide new information on the deglacial and post-glacial evolution of the Arctic–Pacific connection through the Bering Strait based on analyses of geological and geophysical data from Herald Canyon, located north of the Bering Strait on the Chukchi Sea shelf region in the western Arctic Ocean. Our results suggest an initial opening at about 11 cal ka BP in the earliest Holocene, which is later than in several previous studies. Our key evidence is based on a well-dated core from Herald Canyon, in which a shift from a near-shore environment to a Pacific-influenced open marine setting at around 11 cal ka BP is observed. The shift corresponds to meltwater pulse 1b (MWP1b) and is interpreted to signify relatively rapid breaching of the Bering Strait and the submergence of the large Bering Land Bridge. Although the precise rates of sea level rise cannot be quantified, our new results suggest that the late deglacial sea level rise was rapid and occurred after the end of the Younger Dryas stadial.

  10. Post-glacial flooding of the Bering Land Bridge dated to 11 cal ka BP based on new geophysical and sediment records

    NASA Astrophysics Data System (ADS)

    Jakobsson, Martin; Pearce, Christof; Cronin, Thomas M.; Backman, Jan; Anderson, Leif G.; Barrientos, Natalia; Björk, Göran; Coxall, Helen; de Boer, Agatha; Mayer, Larry A.; Mörth, Carl-Magnus; Nilsson, Johan; Rattray, Jayne E.; Stranne, Christian; Semiletov, Igor; O'Regan, Matt

    2017-08-01

    The Bering Strait connects the Arctic and Pacific oceans and separates the North American and Asian landmasses. The presently shallow ( ˜ 53 m) strait was exposed during the sea level lowstand of the last glacial period, which permitted human migration across a land bridge today referred to as the Bering Land Bridge. Proxy studies (stable isotope composition of foraminifera, whale migration into the Arctic Ocean, mollusc and insect fossils and paleobotanical data) have suggested a range of ages for the Bering Strait reopening, mainly falling within the Younger Dryas stadial (12.9-11.7 cal ka BP). Here we provide new information on the deglacial and post-glacial evolution of the Arctic-Pacific connection through the Bering Strait based on analyses of geological and geophysical data from Herald Canyon, located north of the Bering Strait on the Chukchi Sea shelf region in the western Arctic Ocean. Our results suggest an initial opening at about 11 cal ka BP in the earliest Holocene, which is later than in several previous studies. Our key evidence is based on a well-dated core from Herald Canyon, in which a shift from a near-shore environment to a Pacific-influenced open marine setting at around 11 cal ka BP is observed. The shift corresponds to meltwater pulse 1b (MWP1b) and is interpreted to signify relatively rapid breaching of the Bering Strait and the submergence of the large Bering Land Bridge. Although the precise rates of sea level rise cannot be quantified, our new results suggest that the late deglacial sea level rise was rapid and occurred after the end of the Younger Dryas stadial.

  11. Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles.

    PubMed

    Guffei, Amanda; Sarkar, Rahul; Klewes, Ludger; Righolt, Christiaan; Knecht, Hans; Mai, Sabine

    2010-12-01

    Hodgkin's lymphoma is characterized by the presence of mono-nucleated Hodgkin cells and bi- to multi-nucleated Reed-Sternberg cells. We have recently shown telomere dysfunction and aberrant synchronous/asynchronous cell divisions during the transition of Hodgkin cells to Reed-Sternberg cells.1 To determine whether overall changes in nuclear architecture affect genomic instability during the transition of Hodgkin cells to Reed-Sternberg cells, we investigated the nuclear organization of chromosomes in these cells. Three-dimensional fluorescent in situ hybridization revealed irregular nuclear positioning of individual chromosomes in Hodgkin cells and, more so, in Reed-Sternberg cells. We characterized an increasingly unequal distribution of chromosomes as mono-nucleated cells became multi-nucleated cells, some of which also contained chromosome-poor 'ghost' cell nuclei. Measurements of nuclear chromosome positions suggested chromosome overlaps in both types of cells. Spectral karyotyping then revealed both aneuploidy and complex chromosomal rearrangements: multiple breakage-bridge-fusion cycles were at the origin of the multiple rearranged chromosomes. This conclusion was challenged by super resolution three-dimensional structured illumination imaging of Hodgkin and Reed-Sternberg nuclei. Three-dimensional super resolution microscopy data documented inter-nuclear DNA bridges in multi-nucleated cells but not in mono-nucleated cells. These bridges consisted of chromatids and chromosomes shared by two Reed-Sternberg nuclei. The complexity of chromosomal rearrangements increased as Hodgkin cells developed into multi-nucleated cells, thus indicating tumor progression and evolution in Hodgkin's lymphoma, with Reed-Sternberg cells representing the highest complexity in chromosomal rearrangements in this disease. This is the first study to demonstrate nuclear remodeling and associated genomic instability leading to the generation of Reed-Sternberg cells of Hodgkin's lymphoma. We defined nuclear remodeling as a key feature of Hodgkin's lymphoma, highlighting the relevance of nuclear architecture in cancer.

  12. How to create innovation by building the translation bridge from basic research into medicinal drugs: an industrial perspective

    PubMed Central

    2013-01-01

    The global healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities. This decrease in internal research productivity is resulting in a major decline of patent-protected sales (patent cliff) of most of the pharmaceutical companies. Three major global adaptive trends as driving forces to cope with these challenges are evident: cut backs of internal research and development jobs in the western hemisphere (Europe and USA), following the market growth potential of Asia by building up internal or external research and development capabilities there and finally, ‘early innovation hunting’ with an increased focus on identifying and investing in very early innovation sources within academia and small start-up companies. Early innovation hunting can be done by different approaches: increased corporate funding, establishment of translational institutions to bridge innovation, increasing sponsored collaborations and formation of technology hunting groups for capturing very early scientific ideas and concepts. This emerging trend towards early innovation hunting demands special adaptations from both the pharmaceutical industry and basic researchers in academia to bridge the translation into new medicines which deliver innovative medicines that matters to the patient. This opinion article describes the different modalities of cross-fertilisation between basic university or publicly funded institutional research and the applied research and development activities within the pharmaceutical industry. Two key factors in this important translational bridge can be identified: preparation of both partnering organisations to open up for new and sometime disruptive ideas and creation of truly trust-based relationships between the different groups allowing long-term scientific collaborations while acknowledging that value-creating differences are an essential factor for successful collaboration building. PMID:23496921

  13. How to create innovation by building the translation bridge from basic research into medicinal drugs: an industrial perspective.

    PubMed

    Germann, Paul G; Schuhmacher, Alexander; Harrison, Juan; Law, Ronald; Haug, Kevin; Wong, Gordon

    2013-03-05

    The global healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities. This decrease in internal research productivity is resulting in a major decline of patent-protected sales (patent cliff) of most of the pharmaceutical companies. Three major global adaptive trends as driving forces to cope with these challenges are evident: cut backs of internal research and development jobs in the western hemisphere (Europe and USA), following the market growth potential of Asia by building up internal or external research and development capabilities there and finally, 'early innovation hunting' with an increased focus on identifying and investing in very early innovation sources within academia and small start-up companies. Early innovation hunting can be done by different approaches: increased corporate funding, establishment of translational institutions to bridge innovation, increasing sponsored collaborations and formation of technology hunting groups for capturing very early scientific ideas and concepts. This emerging trend towards early innovation hunting demands special adaptations from both the pharmaceutical industry and basic researchers in academia to bridge the translation into new medicines which deliver innovative medicines that matters to the patient. This opinion article describes the different modalities of cross-fertilisation between basic university or publicly funded institutional research and the applied research and development activities within the pharmaceutical industry. Two key factors in this important translational bridge can be identified: preparation of both partnering organisations to open up for new and sometime disruptive ideas and creation of truly trust-based relationships between the different groups allowing long-term scientific collaborations while acknowledging that value-creating differences are an essential factor for successful collaboration building.

  14. The Cuba–United States Thaw: Building Bridges through Science and Global Health

    PubMed Central

    Bausch, Daniel G.; Kouri, Vivian; Resik, Sonia; Acosta, Belsy; Guillen, Gerardo; Goraleski, Karen; Espinal, Marcos; Guzman, Maria G.

    2017-01-01

    Beginning in 2014, there has been significant progress in normalization of relations between Cuba and the United States. Herein, we discuss the history and recent progress in scientific collaboration between the two countries as well as the continued challenges. Science and global health diplomacy can be key tools in reestablishing a trusting and productive relationship of mutual and global benefit, bringing about better and healthier lives for people in both Cuba and the United States. PMID:28719268

  15. Military Review: The Professional Journal of the U.S. Army. Volume 89, Number 1, January-February 2009

    DTIC Science & Technology

    2009-02-01

    GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S...with services in Qarguhliyah, resulting in iraqi government projects to resurface a key road in the area, build a bridge to replace a damaged span...to an iraqi civil conservation force to perform public works functions such as trash removal and municipal improvement projects under the direction

  16. The Cuba-United States Thaw: Building Bridges Through Science and Global Health.

    PubMed

    Bausch, Daniel G; Kouri, Vivian; Resik, Sonia; Acosta, Belsy; Guillen, Gerardo; Goraleski, Karen; Espinal, Marcos; Guzman, Maria G

    2017-06-01

    AbstractBeginning in 2014, there has been significant progress in normalization of relations between Cuba and the United States. Herein, we discuss the history and recent progress in scientific collaboration between the two countries as well as the continued challenges. Science and global health diplomacy can be key tools in reestablishing a trusting and productive relationship of mutual and global benefit, bringing about better and healthier lives for people in both Cuba and the United States.

  17. What we need is theory of human cooperation (and meta-analysis) to bridge the gap between the lab and the wild.

    PubMed

    Van Lange, Paul A M; Balliet, Daniel P; IJzerman, Hans

    2012-02-01

    This commentary seeks to clarify the potential discrepancy between lab-based and field data in the use and effectiveness of punishment to promote cooperation by recommending theory that outlines key differences between the lab and field, such as the shadow of the future and degree of information availability. We also discuss a recent meta-analysis (Balliet et al. 2011) that does not support all conclusions outlined in Guala's target article.

  18. Project CHECO Southeast Asia Report. Rolling Thunder, January 1967 - November 1968

    DTIC Science & Technology

    1969-10-01

    APPENDIX 5, Neut (alized o( Abandoned A list of inactive targets previously li,ted prima(ily in APPENDiX 4 that had been neutralized I- or abandoned and...struck was Van Dien Battery Plant for which no BDA was avail- able. " TRANSPORTATION, A major interdiction effort continued against the key lines of...the Laos Bor- der . Bridges that have not been used regularly s?,nce the bombing started are up and in use on LOCs leading to the DMZ. In short, the

  19. Scientific innovation's two Valleys of Death: how blood and tissue banks can help to bridge the gap.

    PubMed

    Thompson, Sean D A

    2014-12-01

    Most biomedical basic research in the United States takes place at universities and research institutes and is funded by federal grants. Basic research is awarded billions of federal dollars every year, enabling new discoveries and greater understanding of the fundamental science that makes new innovations and therapies possible. However, when basic research yields an invention of practical use and the research evolves from basic to applied, the playing field changes. Pre-technology licensing federal dollars all but disappear, and innovations rely predominantly on private funding to support the full path from bench to bedside. It is along this path that the scientific advance faces two Valleys of Death. These sometimes insurmountable development stages are the product of the innovation's inherent financial, business and investment risks. Well-planned and executed in vivo studies using quality biological materials demonstrating proof-of-concept is often the key to bridging these gaps, and blood and tissue banks offer unique services and resources to enable this process.

  20. Dynamic switching mechanisms of a CC chemokine, CCL5 (RANTES). A simulation study

    NASA Astrophysics Data System (ADS)

    Peter, Emanuel; Pivkin, Igor

    CCL5 (RANTES) belongs to the class of pro-inflammatory chemokines which are part of the human immune-response. It is known to activate leukocytes through its associated chemokine receptor 5 (CCR5) and plays a key role in several malignancies, including HIV-1 infections and cancer. In this talk, we present our results from enhanced sampling simulations of the CCL5 (RANTES) monomer. We find that this protein can adopt 2 different conformations : a globular form, with an orthogonal alignment of the N-terminal part, and a 'cis' form, in which the N-terminus is aligned parallel to the β-strand interface. A detailed analysis of the structure reveals that each of these states is stabilized by salt-bridges along the sequence, and corresponds to a defined dihedral-geometry of the 2 disulfide bridges Cys10-34 and Cys11-50. We derive a uniform distribution of transitions from the globular form of CCL5 (RANTES), and find that each of the main conformers adopts different electrostatic patterns.

  1. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.

    PubMed

    Martin, Carol-Anne; Murray, Jennie E; Carroll, Paula; Leitch, Andrea; Mackenzie, Karen J; Halachev, Mihail; Fetit, Ahmed E; Keith, Charlotte; Bicknell, Louise S; Fluteau, Adeline; Gautier, Philippe; Hall, Emma A; Joss, Shelagh; Soares, Gabriela; Silva, João; Bober, Michael B; Duker, Angela; Wise, Carol A; Quigley, Alan J; Phadke, Shubha R; Wood, Andrew J; Vagnarelli, Paola; Jackson, Andrew P

    2016-10-01

    Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome structure. Here, we report that biallelic mutations in NCAPD2, NCAPH, or NCAPD3, encoding subunits of these complexes, cause microcephaly. In addition, hypomorphic Ncaph2 mice have significantly reduced brain size, with frequent anaphase chromatin bridge formation observed in apical neural progenitors during neurogenesis. Such DNA bridges also arise in condensin-deficient patient cells, where they are the consequence of failed sister chromatid disentanglement during chromosome compaction. This results in chromosome segregation errors, leading to micronucleus formation and increased aneuploidy in daughter cells. These findings establish "condensinopathies" as microcephalic disorders, with decatenation failure as an additional disease mechanism for microcephaly, implicating mitotic chromosome condensation as a key process ensuring mammalian cerebral cortex size. © 2016 Martin et al.; Published by Cold Spring Harbor Laboratory Press.

  2. Enzyme-like catalysis via ternary complex mechanism: alkoxy-bridged dinuclear cobalt complex mediates chemoselective O-esterification over N-amidation.

    PubMed

    Hayashi, Yukiko; Santoro, Stefano; Azuma, Yuki; Himo, Fahmi; Ohshima, Takashi; Mashima, Kazushi

    2013-04-24

    Hydroxy group-selective acylation in the presence of more nucleophilic amines was achieved using acetates of first-row late transition metals, such as Mn, Fe, Co, Cu, and Zn. Among them, cobalt(II) acetate was the best catalyst in terms of reactivity and selectivity. The combination of an octanuclear cobalt carboxylate cluster [Co4(OCOR)6O]2 (2a: R = CF3, 2b: R = CH3, 2c: R = (t)Bu) with nitrogen-containing ligands, such as 2,2'-bipyridine, provided an efficient catalytic system for transesterification, in which an alkoxide-bridged dinuclear complex, Co2(OCO(t)Bu)2(bpy)2(μ2-OCH2-C6H4-4-CH3)2 (10), was successfully isolated as a key intermediate. Kinetic studies and density functional theory calculations revealed Michaelis-Menten behavior of the complex 10 through an ordered ternary complex mechanism similar to dinuclear metallo-enzymes, suggesting the formation of alkoxides followed by coordination of the ester.

  3. Dissociative adsorption of O2 on unreconstructed metal (100) surfaces: Pathways, energetics, and sticking kinetics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Da-Jiang; Evans, James W.

    An accurate description of oxygen dissociation pathways and kinetics for various local adlayer environments is key for an understanding not just of the coverage dependence of oxygen sticking, but also of reactive steady states in oxidation reactions. Density functional theory analysis for M(100) surfaces with M=Pd, Rh, and Ni, where O prefers the fourfold hollow adsorption site, does not support the traditional Brundle-Behm-Barker picture of dissociative adsorption onto second-nearest-neighbor hollow sites with an additional blocking constraint. Rather adsorption via neighboring vicinal bridge sites dominates, although other pathways can be active. The same conclusion also applies for M=Pt and Ir, wheremore » oxygen prefers the bridge adsorption site. Statistical mechanical analysis is performed based on kinetic Monte Carlo simulation of a multisite lattice-gas model consistent with our revised picture of adsorption. This analysis determines the coverage and temperature dependence of sticking for a realistic treatment of the oxygen adlayer structure.« less

  4. Ultrasonic wave-based structural health monitoring embedded instrument.

    PubMed

    Aranguren, G; Monje, P M; Cokonaj, Valerijan; Barrera, Eduardo; Ruiz, Mariano

    2013-12-01

    Piezoelectric sensors and actuators are the bridge between electronic and mechanical systems in structures. This type of sensor is a key element in the integrity monitoring of aeronautic structures, bridges, pressure vessels, wind turbine blades, and gas pipelines. In this paper, an all-in-one system for Structural Health Monitoring (SHM) based on ultrasonic waves is presented, called Phased Array Monitoring for Enhanced Life Assessment. This integrated instrument is able to generate excitation signals that are sent through piezoelectric actuators, acquire the received signals in the piezoelectric sensors, and carry out signal processing to check the health of structures. To accomplish this task, the instrument uses a piezoelectric phased-array transducer that performs the actuation and sensing of the signals. The flexibility and strength of the instrument allow the user to develop and implement a substantial part of the SHM technique using Lamb waves. The entire system is controlled using configuration software and has been validated through functional, electrical loading, mechanical loading, and thermal loading resistance tests.

  5. Sensory neural pathways revisited to unravel the temporal dynamics of the Simon effect: A model-based cognitive neuroscience approach.

    PubMed

    Salzer, Yael; de Hollander, Gilles; Forstmann, Birte U

    2017-06-01

    The Simon task is one of the most prominent interference tasks and has been extensively studied in experimental psychology and cognitive neuroscience. Despite years of research, the underlying mechanism driving the phenomenon and its temporal dynamics are still disputed. Within the framework of the review, we adopt a model-based cognitive neuroscience approach. We first go over key findings in the literature of the Simon task, discuss competing qualitative cognitive theories and the difficulty of testing them empirically. We then introduce sequential sampling models, a particular class of mathematical cognitive process models. Finally, we argue that the brain architecture accountable for the processing of spatial ('where') and non-spatial ('what') information, could constrain these models. We conclude that there is a clear need to bridge neural and behavioral measures, and that mathematical cognitive models may facilitate the construction of this bridge and work towards revealing the underlying mechanisms of the Simon effect. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Synthesis of a Neutral Mixed-Valence Diferrocenyl Carborane for Molecular Quantum-Dot Cellular Automata Applications.

    PubMed

    Christie, John A; Forrest, Ryan P; Corcelli, Steven A; Wasio, Natalie A; Quardokus, Rebecca C; Brown, Ryan; Kandel, S Alex; Lu, Yuhui; Lent, Craig S; Henderson, Kenneth W

    2015-12-14

    The preparation of 7-Fc(+) -8-Fc-7,8-nido-[C2 B9 H10 ](-) (Fc(+) FcC2 B9 (-) ) demonstrates the successful incorporation of a carborane cage as an internal counteranion bridging between ferrocene and ferrocenium units. This neutral mixed-valence Fe(II) /Fe(III) complex overcomes the proximal electronic bias imposed by external counterions, a practical limitation in the use of molecular switches. A combination of UV/Vis-NIR spectroscopic and TD-DFT computational studies indicate that electron transfer within Fc(+) FcC2 B9 (-) is achieved through a bridge-mediated mechanism. This electronic framework therefore provides the possibility of an all-neutral null state, a key requirement for the implementation of quantum-dot cellular automata (QCA) molecular computing. The adhesion, ordering, and characterization of Fc(+) FcC2 B9 (-) on Au(111) has been observed by scanning tunneling microscopy. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Recent advances in computational methodology for simulation of mechanical circulatory assist devices

    PubMed Central

    Marsden, Alison L.; Bazilevs, Yuri; Long, Christopher C.; Behr, Marek

    2014-01-01

    Ventricular assist devices (VADs) provide mechanical circulatory support to offload the work of one or both ventricles during heart failure. They are used in the clinical setting as destination therapy, as bridge to transplant, or more recently as bridge to recovery to allow for myocardial remodeling. Recent developments in computational simulation allow for detailed assessment of VAD hemodynamics for device design and optimization for both children and adults. Here, we provide a focused review of the recent literature on finite element methods and optimization for VAD simulations. As VAD designs typically fall into two categories, pulsatile and continuous flow devices, we separately address computational challenges of both types of designs, and the interaction with the circulatory system with three representative case studies. In particular, we focus on recent advancements in finite element methodology that has increased the fidelity of VAD simulations. We outline key challenges, which extend to the incorporation of biological response such as thrombosis and hemolysis, as well as shape optimization methods and challenges in computational methodology. PMID:24449607

  8. Perceptual awareness and its neural basis: bridging experimental and theoretical paradigms

    PubMed Central

    Raffone, Antonino; Srinivasan, Narayanan; van Leeuwen, Cees

    2014-01-01

    Understanding consciousness is a major scientific challenge of our times, and perceptual awareness is an integral part of that challenge. This Theme Issue aims to provide a timely focus on crucial insights from leading scientists on perceptual awareness and its neural basis. The issue refers to key research questions and findings in perceptual awareness research and aims to be a catalyst for further research, by bringing together the state-of-the-art. It shows how bridges are being built between empirical and theoretical research and proposes new directions for the study of multisensory awareness and the role of the states of the body therein. In this introduction, we highlight crucial problems that have characterized the development of the study of perceptual awareness. We then provide an overview of major experimental and theoretical paradigms related to perceptual awareness and its neural basis. Finally, we present an overview of the Theme Issue, with reference to the contributed articles and their relationships. PMID:24639576

  9. The Meyerhoff Way: How the Meyerhoff Scholarship Program Helps Black Students Succeed in the Sciences

    NASA Astrophysics Data System (ADS)

    Stolle-McAllister, Kathy; Sto. Domingo, Mariano R.; Carrillo, Amy

    2011-02-01

    The Meyerhoff Scholarship Program (MSP) is widely recognized for its comprehensive approach of integrating students into the science community. The supports provided by the program aim to develop students, primarily Blacks, into scientists by offering them academic, social, and professional opportunities to achieve their academic and career goals. The current study allowed for a rich understanding of the perceptions of current Meyerhoff students and Meyerhoff alumni about how the program works. Three groups of MSP students were included in the study: (1) new Meyerhoff students participating in Summer Bridge ( n = 45), (2) currently enrolled Meyerhoff students ( n = 92), and (3) graduates of the MSP who were currently enrolled in STEM graduate studies or had completed an advanced STEM degree ( n = 19). Students described the importance of several key aspects of the MSP: financial support, the Summer Bridge Program, formation of Meyerhoff identity, belonging to the Meyerhoff family, and developing networks—all of which serve to integrate students both academically and socially.

  10. The Meyerhoff Way: How the Meyerhoff Scholarship Program Helps Black Students Succeed in the Sciences

    PubMed Central

    Stolle-McAllister, Kathy; Sto. Domingo, Mariano R.; Carrillo, Amy

    2011-01-01

    The Meyerhoff Scholarship Program (MSP) is widely recognized for its comprehensive approach of integrating students into the science community. The supports provided by the program aim to develop students, primarily Blacks, into scientists by offering them academic, social, and professional opportunities to achieve their academic and career goals. The current study allowed for a rich understanding of the perceptions of current Meyerhoff students and Meyerhoff alumni about how the program works. Three groups of MSP students were included in the study: 1) new Meyerhoff students participating in Summer Bridge (n=45), 2) currently enrolled Meyerhoff students (n=92), and 3) graduates of the MSP who were currently enrolled in STEM graduate studies or had completed an advanced STEM degree (n=19). Students described the importance of several key aspects of the Meyerhoff Scholars Program: financial support, the Summer Bridge Program, formation of Meyerhoff identity, belonging to the Meyerhoff family, and developing networks - all of which serve to integrate students both academically and socially. PMID:21850153

  11. Scientific Innovation's Two Valleys of Death: How Blood and Tissue Banks Can Help to Bridge the Gap

    PubMed Central

    Thompson, Sean D.A.

    2014-01-01

    Abstract Most biomedical basic research in the United States takes place at universities and research institutes and is funded by federal grants. Basic research is awarded billions of federal dollars every year, enabling new discoveries and greater understanding of the fundamental science that makes new innovations and therapies possible. However, when basic research yields an invention of practical use and the research evolves from basic to applied, the playing field changes. Pre-technology licensing federal dollars all but disappear, and innovations rely predominantly on private funding to support the full path from bench to bedside. It is along this path that the scientific advance faces two Valleys of Death. These sometimes insurmountable development stages are the product of the innovation’s inherent financial, business and investment risks. Well-planned and executed in vivo studies using quality biological materials demonstrating proof-of-concept is often the key to bridging these gaps, and blood and tissue banks offer unique services and resources to enable this process. PMID:25457967

  12. Three Bridge Fryer's Ford Bridge, Nimrod Bridge, and Ward's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Three Bridge - Fryer's Ford Bridge, Nimrod Bridge, and Ward's Crossing Bridge - Fryer's Ford Bridge, Spanning East Fork of Point Remove Creek at Fryer Bridge Road (CR 67), Solgohachia, Conway County, AR

  13. 47 CFR 80.1007 - Bridge-to-bridge radiotelephone installation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bridge-to-bridge radiotelephone installation. 80.1007 Section 80.1007 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Bridge-to-Bridge Act § 80.1007 Bridge-to-bridge radiotelephone installation. Use of the bridge-to-bridge...

  14. 47 CFR 80.1007 - Bridge-to-bridge radiotelephone installation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bridge-to-bridge radiotelephone installation. 80.1007 Section 80.1007 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Bridge-to-Bridge Act § 80.1007 Bridge-to-bridge radiotelephone installation. Use of the bridge-to-bridge...

  15. Influence of Holocene environmental change and anthropogenic impact on the diversity and distribution of roe deer

    PubMed Central

    Baker, K H; Hoelzel, A R

    2014-01-01

    Extant patterns of population structure and levels of diversity are a consequence of factors that vary in both space and time. Our objective in this study is to investigate a species that has responded to both natural and anthropogenic changes in ways that have shaped modern populations and provide insight into the key processes. The roe deer (Capreolus capreolus) is one of the two species of deer native to Britain. During the last glacial maximum (LGM), the British habitat was largely under ice and there was a land bridge to mainland Europe. As the Earth warmed during the early Holocene, the land bridge was lost. Subsequent hunting on the British mainland left the southern region extirpated of roe deer, whereas a refugial population remained in the north. Later reintroductions from Europe led to population expansion, especially in southern United Kingdom. Here, we combine data from ancient and modern DNA to track population dynamics and patterns of connectivity, and test hypotheses about the influence of natural and anthropogenic environmental change. We find that past expansion and divergence events coincided with a warming environment and the subsequent closure of the land bridge between Europe and the United Kingdom. We also find turnover in British roe deer haplotypes between the late-Holocene and modern day that have likely resulted from recent human disturbance activities such as habitat perturbation, overhunting and restocking. PMID:24448563

  16. Influence of Holocene environmental change and anthropogenic impact on the diversity and distribution of roe deer.

    PubMed

    Baker, K H; Hoelzel, A R

    2014-06-01

    Extant patterns of population structure and levels of diversity are a consequence of factors that vary in both space and time. Our objective in this study is to investigate a species that has responded to both natural and anthropogenic changes in ways that have shaped modern populations and provide insight into the key processes. The roe deer (Capreolus capreolus) is one of the two species of deer native to Britain. During the last glacial maximum (LGM), the British habitat was largely under ice and there was a land bridge to mainland Europe. As the Earth warmed during the early Holocene, the land bridge was lost. Subsequent hunting on the British mainland left the southern region extirpated of roe deer, whereas a refugial population remained in the north. Later reintroductions from Europe led to population expansion, especially in southern United Kingdom. Here, we combine data from ancient and modern DNA to track population dynamics and patterns of connectivity, and test hypotheses about the influence of natural and anthropogenic environmental change. We find that past expansion and divergence events coincided with a warming environment and the subsequent closure of the land bridge between Europe and the United Kingdom. We also find turnover in British roe deer haplotypes between the late-Holocene and modern day that have likely resulted from recent human disturbance activities such as habitat perturbation, overhunting and restocking.

  17. Distinct roles for key karyogamy proteins during yeast nuclear fusion.

    PubMed

    Melloy, Patricia; Shen, Shu; White, Erin; Rose, Mark D

    2009-09-01

    During yeast mating, cell fusion is followed by the congression and fusion of the two nuclei. Proteins required for nuclear fusion are found at the surface (Prm3p) and within the lumen (Kar2p, Kar5p, and Kar8p) of the nuclear envelope (NE). Electron tomography (ET) of zygotes revealed that mutations in these proteins block nuclear fusion with different morphologies, suggesting that they act in different steps of fusion. Specifically, prm3 zygotes were blocked before formation of membrane bridges, whereas kar2, kar5, and kar8 zygotes frequently contained them. Membrane bridges were significantly larger and occurred more frequently in kar2 and kar8, than in kar5 mutant zygotes. The kinetics of NE fusion in prm3, kar5, and kar8 mutants, measured by live-cell fluorescence microscopy, were well correlated with the size and frequency of bridges observed by ET. However the kar2 mutant was defective for transfer of NE lumenal GFP, but not diffusion within the lumen, suggesting that transfer was blocked at the NE fusion junction. These observations suggest that Prm3p acts before initiation of outer NE fusion, Kar5p may help dilation of the initial fusion pore, and Kar2p and Kar8p act after outer NE fusion, during inner NE fusion.

  18. Unique self-assembly properties of a bridge-shaped protein dimer with quantum dots

    NASA Astrophysics Data System (ADS)

    Wang, Jianhao; Jiang, Pengju; Gao, Liqian; Yu, Yongsheng; Lu, Yao; Qiu, Lin; Wang, Cheli; Xia, Jiang

    2013-09-01

    How protein-protein interaction affects protein-nanoparticle self-assembly is the key to the understanding of biomolecular coating of nanoparticle in biological fluids. However, the relationship between protein shape and its interaction with nanoparticles is still under-exploited because of lack of a well-conceived binding system and a method to detect the subtle change in the protein-nanoparticle assemblies. Noticing this unresolved need, we cloned and expressed a His-tagged SpeA protein that adopts a bridge-shaped dimer structure, and utilized a high-resolution capillary electrophoresis method to monitor assembly formation between the protein and quantum dots (QDs, 5 nm in diameter). We observed that the bridge-shaped structure rendered a low SpeA:QD stoichiometry at saturation. Also, close monitoring of imidazole (Im) displacement of surface-bound protein revealed a unique two-step process. High-concentration Im could displace surface-bound SpeA protein and form a transient QD-protein intermediate, through a kinetically controlled displacement process. An affinity-driven equilibrium step then followed, resulting in re-assembling of the QD-protein complex in about 1 h. Through a temporarily formed intermediate, Im causes a rearrangement of His-tagged proteins on the surface. Thus, our work showcases that the synergistic interplay between QD-His-tag interaction and protein-protein interaction can result in unique properties of protein-nanoparticle assembly for the first time.

  19. A construct-network approach to bridging diagnostic and physiological domains: application to assessment of externalizing psychopathology.

    PubMed

    Patrick, Christopher J; Venables, Noah C; Yancey, James R; Hicks, Brian M; Nelson, Lindsay D; Kramer, Mark D

    2013-08-01

    A crucial challenge in efforts to link psychological disorders to neural systems, with the aim of developing biologically informed conceptions of such disorders, is the problem of method variance (Campbell & Fiske, 1959). Since even measures of the same construct in differing domains correlate only moderately, it is unsurprising that large sample studies of diagnostic biomarkers yield only modest associations. To address this challenge, a construct-network approach is proposed in which psychometric operationalizations of key neurobehavioral constructs serve as anchors for identifying neural indicators of psychopathology-relevant dispositions, and as vehicles for bridging between domains of clinical problems and neurophysiology. An empirical illustration is provided for the construct of inhibition-disinhibition, which is of central relevance to problems entailing deficient impulse control. Findings demonstrate that: (1) a well-designed psychometric index of trait disinhibition effectively predicts externalizing problems of multiple types, (2) this psychometric measure of disinhibition shows reliable brain response correlates, and (3) psychometric and brain-response indicators can be combined to form a joint psychoneurometric factor that predicts effectively across clinical and physiological domains. As a methodology for bridging between clinical problems and neural systems, the construct-network approach provides a concrete means by which existing conceptions of psychological disorders can accommodate and be reshaped by neurobiological insights. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  20. Monitoring of prestress losses using long-gauge fiber optic sensors

    NASA Astrophysics Data System (ADS)

    Abdel-Jaber, Hiba; Glisic, Branko

    2017-04-01

    Prestressed concrete has been increasingly used in the construction of bridges due to its superiority as a building material. This has necessitated better assessment of its on-site performance. One of the most important indicators of structural integrity and performance of prestressed concrete structures is the spatial distribution of prestress forces over time, i.e. prestress losses along the structure. Time-dependent prestress losses occur due to dimensional changes in the concrete caused by creep and shrinkage, in addition to strand relaxation. Maintaining certain force levels in the strands, and thus the concrete cross-sections, is essential to ensuring stresses in the concrete do not exceed design stresses, which could cause malfunction or failure of the structure. This paper presents a novel method for monitoring prestress losses based on long-gauge fiber optic sensors embedded in the concrete during construction. The method includes the treatment of varying environmental factors such as temperature to ensure accuracy of results in on-site applications. The method is presented as applied to a segment of a post-tensioned pedestrian bridge on the Princeton University campus, Streicker Bridge. The segment is a three-span continuous girder supported on steel columns, with sensors embedded at key locations along the structure during construction in October 2009. Temperature and strain measurements have been recorded intermittently since construction. The prestress loss results are compared to estimates from design documents.

  1. Bridging the gap: from massive stars to supernovae

    PubMed Central

    Crowther, Paul A.; Janka, Hans-Thomas; Langer, Norbert

    2017-01-01

    Almost since the beginning, massive stars and their resultant supernovae have played a crucial role in the Universe. These objects produce tremendous amounts of energy and new, heavy elements that enrich galaxies, encourage new stars to form and sculpt the shapes of galaxies that we see today. The end of millions of years of massive star evolution and the beginning of hundreds or thousands of years of supernova evolution are separated by a matter of a few seconds, in which some of the most extreme physics found in the Universe causes the explosive and terminal disruption of the star. Key questions remain unanswered in both the studies of how massive stars evolve and the behaviour of supernovae, and it appears the solutions may not lie on just one side of the explosion or the other or in just the domain of the stellar evolution or the supernova astrophysics communities. The need to view massive star evolution and supernovae as continuous phases in a single narrative motivated the Theo Murphy international scientific meeting ‘Bridging the gap: from massive stars to supernovae’ at Chicheley Hall, UK, in June 2016, with the specific purpose of simultaneously addressing the scientific connections between theoretical and observational studies of massive stars and their supernovae, through engaging astronomers from both communities. This article is part of the themed issue ‘Bridging the gap: from massive stars to supernovae’. PMID:28923995

  2. Bridging the gap: from massive stars to supernovae.

    PubMed

    Maund, Justyn R; Crowther, Paul A; Janka, Hans-Thomas; Langer, Norbert

    2017-10-28

    Almost since the beginning, massive stars and their resultant supernovae have played a crucial role in the Universe. These objects produce tremendous amounts of energy and new, heavy elements that enrich galaxies, encourage new stars to form and sculpt the shapes of galaxies that we see today. The end of millions of years of massive star evolution and the beginning of hundreds or thousands of years of supernova evolution are separated by a matter of a few seconds, in which some of the most extreme physics found in the Universe causes the explosive and terminal disruption of the star. Key questions remain unanswered in both the studies of how massive stars evolve and the behaviour of supernovae, and it appears the solutions may not lie on just one side of the explosion or the other or in just the domain of the stellar evolution or the supernova astrophysics communities. The need to view massive star evolution and supernovae as continuous phases in a single narrative motivated the Theo Murphy international scientific meeting 'Bridging the gap: from massive stars to supernovae' at Chicheley Hall, UK, in June 2016, with the specific purpose of simultaneously addressing the scientific connections between theoretical and observational studies of massive stars and their supernovae, through engaging astronomers from both communities.This article is part of the themed issue 'Bridging the gap: from massive stars to supernovae'. © 2017 The Author(s).

  3. Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

    PubMed Central

    Kensler, Robert W.; Craig, Roger; Moss, Richard L.

    2017-01-01

    Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and the fully phosphorylated state of cMyBP-C, respectively. We found that thick filaments from the cMyBP-C phospho-deficient hearts had highly ordered cross-bridge arrays, whereas the filaments from the cMyBP-C phospho-mimetic hearts showed a strong tendency toward disorder. Our results support the hypothesis that dephosphorylation of cMyBP-C promotes or stabilizes the relaxed/superrelaxed quasi-helical ordering of the myosin heads on the filament surface, whereas phosphorylation weakens this stabilization and binding of the heads to the backbone. Such structural changes would modulate the probability of myosin binding to actin and could help explain the acceleration of cross-bridge interactions with actin when cMyBP-C is phosphorylated because of, for example, activation of β1-adrenergic receptors in myocardium. PMID:28167762

  4. Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments.

    PubMed

    Kensler, Robert W; Craig, Roger; Moss, Richard L

    2017-02-21

    Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and the fully phosphorylated state of cMyBP-C, respectively. We found that thick filaments from the cMyBP-C phospho-deficient hearts had highly ordered cross-bridge arrays, whereas the filaments from the cMyBP-C phospho-mimetic hearts showed a strong tendency toward disorder. Our results support the hypothesis that dephosphorylation of cMyBP-C promotes or stabilizes the relaxed/superrelaxed quasi-helical ordering of the myosin heads on the filament surface, whereas phosphorylation weakens this stabilization and binding of the heads to the backbone. Such structural changes would modulate the probability of myosin binding to actin and could help explain the acceleration of cross-bridge interactions with actin when cMyBP-C is phosphorylated because of, for example, activation of β 1 -adrenergic receptors in myocardium.

  5. NASA IceBridge: Scientific Insights from Airborne Surveys of the Polar Sea Ice Covers

    NASA Astrophysics Data System (ADS)

    Richter-Menge, J.; Farrell, S. L.

    2015-12-01

    The NASA Operation IceBridge (OIB) airborne sea ice surveys are designed to continue a valuable series of sea ice thickness measurements by bridging the gap between NASA's Ice, Cloud and Land Elevation Satellite (ICESat), which operated from 2003 to 2009, and ICESat-2, which is scheduled for launch in 2017. Initiated in 2009, OIB has conducted campaigns over the western Arctic Ocean (March/April) and Southern Oceans (October/November) on an annual basis when the thickness of sea ice cover is nearing its maximum. More recently, a series of Arctic surveys have also collected observations in the late summer, at the end of the melt season. The Airborne Topographic Mapper (ATM) laser altimeter is one of OIB's primary sensors, in combination with the Digital Mapping System digital camera, a Ku-band radar altimeter, a frequency-modulated continuous-wave (FMCW) snow radar, and a KT-19 infrared radiation pyrometer. Data from the campaigns are available to the research community at: http://nsidc.org/data/icebridge/. This presentation will summarize the spatial and temporal extent of the OIB campaigns and their complementary role in linking in situ and satellite measurements, advancing observations of sea ice processes across all length scales. Key scientific insights gained on the state of the sea ice cover will be highlighted, including snow depth, ice thickness, surface roughness and morphology, and melt pond evolution.

  6. Asia's communications market booms

    NASA Astrophysics Data System (ADS)

    Davis, Neil W.

    1995-01-01

    Asia's communications and direct broadcasting satellite business markets has bloomed, with a growing number of Asian-owned communications satellites launched and others purchased for imminent use. Ironically, Hong Kong now possesses Asia's most successful satellite TV broadcasting firm, even though it does not hold the keys to the actual technology. In contrast, Japan holds virtually all the technical keys but companies are bogged down by financial trouble, the absence of a local enterprise equivalent to telecommunications, and bureaucratic intervention. Due to large trade deficits vis-a-vis Tokyo and lower prices offered by US and European telecom equipment suppliers, Asian countries are not buying from Japan. Currently, excessive competition is likely to come from other Asian countries, prompting Japanese firms surprised by this development to attempt at 'bridging' the competition gap with the US and European suppliers.

  7. Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases.

    PubMed

    Zhang, Yi; Tang, Jun; Tian, Zhiqiang; van Velkinburgh, Jennifer C; Song, Jianxun; Wu, Yuzhang; Ni, Bing

    2016-09-02

    Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.

  8. A systematic literature review of engineering identity: definitions, factors, and interventions affecting development, and means of measurement

    NASA Astrophysics Data System (ADS)

    Morelock, John R.

    2017-11-01

    Studies exploring what it means to be an engineer professionally have been conducted for decades, but have boomed in recent years. This systematic literature review aims to organise extant studies on engineering identity by coding around four key variables: (a) definitions of engineering identity, (b) factors affecting engineering identity development, (c) interventions affecting engineering identity development, and (d) means of measuring identity. In doing so, this review provides strategies for future research and educational interventions to advance work related to engineering identity. Publications were selected for inclusion by screening and appraising results obtained from databases and keywords refined through a scoping study. Derived from key findings, suggestions for future research include bridging disparate strands of engineering identity literature and incorporating more varied methodological approaches. Also from key findings, suggestions for future practice involve better connecting existing definitions of engineering identity and factors known to affect identity development with identity-related interventions.

  9. Probabilistic seismic hazard assessment for the effect of vertical ground motions on seismic response of highway bridges

    NASA Astrophysics Data System (ADS)

    Yilmaz, Zeynep

    Typically, the vertical component of the ground motion is not considered explicitly in seismic design of bridges, but in some cases the vertical component can have a significant effect on the structural response. The key question of when the vertical component should be incorporated in design is answered by the probabilistic seismic hazard assessment study incorporating the probabilistic seismic demand models and ground motion models. Nonlinear simulation models with varying configurations of an existing bridge in California were considered in the analytical study. The simulation models were subjected to the set of selected ground motions in two stages: at first, only horizontal components of the motion were applied; while in the second stage the structures were subjected to both horizontal and vertical components applied simultaneously and the ground motions that produced the largest adverse effects on the bridge system were identified. Moment demand in the mid-span and at the support of the longitudinal girder and the axial force demand in the column are found to be significantly affected by the vertical excitations. These response parameters can be modeled using simple ground motion parameters such as horizontal spectral acceleration and vertical spectral acceleration within 5% to 30% error margin depending on the type of the parameter and the period of the structure. For a complete hazard assessment, both of these ground motion parameters explaining the structural behavior should also be modeled. For the horizontal spectral acceleration, Abrahamson and Silva (2008) model was used within many available standard model. A new NGA vertical ground motion model consistent with the horizontal model was constructed. These models are combined in a vector probabilistic seismic hazard analyses. Series of hazard curves developed and presented for different locations in Bay Area for soil site conditions to provide a roadmap for the prediction of these features for future earthquakes. Findings from this study will contribute to the development of revised guidelines to address vertical ground motion effects, particularly in the near fault regions, in the seismic design of highway bridges.

  10. Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness

    PubMed Central

    Sequeira, Vasco; Najafi, Aref; McConnell, Mark; Fowler, Ewan D; Bollen, Ilse A E; Wüst, Rob C I; dos Remedios, Cris; Helmes, Michiel; White, Ed; Stienen, Ger J M; Tardiff, Jil; Kuster, Diederik W D; van der Velden, Jolanda

    2015-01-01

    Abstract Heart failure (HF) with diastolic dysfunction has been attributed to increased myocardial stiffness that limits proper filling of the ventricle. Altered cross-bridge interaction may significantly contribute to high diastolic stiffness, but this has not been shown thus far. Cross-bridge interactions are dependent on cytosolic [Ca2+] and the regeneration of ATP from ADP. Depletion of myocardial energy reserve is a hallmark of HF leading to ADP accumulation and disturbed Ca2+ handling. Here, we investigated if ADP elevation in concert with increased diastolic [Ca2+] promotes diastolic cross-bridge formation and force generation and thereby increases diastolic stiffness. ADP dose-dependently increased force production in the absence of Ca2+ in membrane-permeabilized cardiomyocytes from human hearts. Moreover, physiological levels of ADP increased actomyosin force generation in the presence of Ca2+ both in human and rat membrane-permeabilized cardiomyocytes. Diastolic stress measured at physiological lattice spacing and 37°C in the presence of pathological levels of ADP and diastolic [Ca2+] revealed a 76 ± 1% contribution of cross-bridge interaction to total diastolic stress in rat membrane-permeabilized cardiomyocytes. Inhibition of creatine kinase (CK), which increases cytosolic ADP, in enzyme-isolated intact rat cardiomyocytes impaired diastolic re-lengthening associated with diastolic Ca2+ overload. In isolated Langendorff-perfused rat hearts, CK inhibition increased ventricular stiffness only in the presence of diastolic [Ca2+]. We propose that elevations of intracellular ADP in specific types of cardiac disease, including those where myocardial energy reserve is limited, contribute to diastolic dysfunction by recruiting cross-bridges, even at low Ca2+, and thereby increase myocardial stiffness. Key points Diastolic dysfunction in heart failure patients is evident from stiffening of the passive properties of the ventricular wall. Increased actomyosin interactions may significantly limit diastolic capacity, however, direct evidence is absent. From experiments at the cellular and whole organ level, in humans and rats, we show that actomyosin-related force development contributes significantly to high diastolic stiffness in environments where high ADP and increased diastolic [Ca2+] are present, such as the failing myocardium. Our basal study provides a mechanical mechanism which may partly underlie diastolic dysfunction. PMID:26096258

  11. 47 CFR 80.331 - Bridge-to-bridge communication procedure.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bridge-to-bridge communication procedure. 80..., Alarm, Urgency and Safety Procedures § 80.331 Bridge-to-bridge communication procedure. (a) Vessels subject to the Bridge-to-Bridge Act transmitting on the designated navigational frequency must conduct...

  12. 47 CFR 80.331 - Bridge-to-bridge communication procedure.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bridge-to-bridge communication procedure. 80..., Alarm, Urgency and Safety Procedures § 80.331 Bridge-to-bridge communication procedure. (a) Vessels subject to the Bridge-to-Bridge Act transmitting on the designated navigational frequency must conduct...

  13. Ionic liquid and deep eutectic solvent-activated CelA2 variants generated by directed evolution.

    PubMed

    Lehmann, Christian; Bocola, Marco; Streit, Wolfgang R; Martinez, Ronny; Schwaneberg, Ulrich

    2014-06-01

    Chemoenzymatic cellulose degradation is one of the key steps for the production of biomass-based fuels under mild conditions. An effective cellulose degradation process requires diverse physico-chemical dissolution of the biomass prior to enzymatic degradation. In recent years, "green" solvents, such as ionic liquids and, more recently, deep eutectic liquids, have been proposed as suitable alternatives for biomass dissolution by homogenous catalysis. In this manuscript, a directed evolution campaign of an ionic liquid tolerant β-1,4-endoglucanase (CelA2) was performed in order to increase its performance in the presence of choline chloride/glycerol (ChCl:Gly) or 1-butyl-3-methylimidazolium chloride ([BMIM]Cl), as a first step to identify residues which govern ionic strength resistance and obtaining insights for employing cellulases on the long run in homogenous catalysis of lignocellulose degradation. After mutant library screening, variant M4 (His288Phe, Ser300Arg) was identified, showing a dramatically reduced activity in potassium phosphate buffer and an increased activity in the presence of ChCl:Gly or [BMIM]Cl. Further characterization showed that the CelA2 variant M4 is activated in the presence of these solvents, representing a first report of an engineered enzyme with an ionic strength activity switch. Structural analysis revealed that Arg300 could be a key residue for the ionic strength activation through a salt bridge with the neighboring Asp287. Experimental and computational results suggest that the salt bridge Asp287-Arg300 generates a nearly inactive CelA2 variant and activity is regained when ChCl:Gly or [BMIM]Cl are supplemented (~5-fold increase from 0.64 to 3.37 μM 4-MU/h with the addition ChCl:Gly and ~23-fold increase from 3.84 to 89.21 μM 4-pNP/h with the addition of [BMIM]Cl). Molecular dynamic simulations further suggest that the salt bridge between Asp287 and Arg300 in variant M4 (His288Phe, Ser300Arg) modulates the observed salt activation.

  14. Capacity Building on the Use of Earth Observation for Bridging the Gaps between Science and Policy

    NASA Astrophysics Data System (ADS)

    Thapa, R. B.; Bajracharya, B.

    2017-12-01

    Although the geospatial technologies and Earth observation (EO) data are getting more accessible, lack of skilled human resources and institutional capacities are the major hurdles in the effective applications in Hindu Kush Himalayan (HKH) region. Designing efficient and cost effective capacity building (CB) programs fitting needs by different users on the use of EO information for decision making will provide options in bridging the gaps in the region. This paper presents the strategies adopted by SERVIR-HKH as an attempt to strengthen the capacity of governments and development stakeholders in the region. SERVIR-HKH hub plays vital role in CB on EO applications by bringing together the leading scientists from the Globe and the key national institutions and stakeholders in the region. We conducted country consultation workshops in Afghanistan, Bangladesh, Pakistan, and Nepal to identify national priorities, requirements and the capacity of the institutions to utilize EO information in decision making. The need assessments were focused on four thematic areas of SERVIR where capacity gaps in utilization of EO data in policy decisions were identified in thirteen key service areas. Geospatial capacities in GIT infrastructure, data, and human resources were varied. Linking EO information to policy decision is mostly lacking. Geospatial data sharing provision among the institutions in the region is poor. We developed a capacity building strategy for HKH region which bridges the gaps in a coordinated manner through customized training programs, institutional strengthening, coordination and regional cooperation. Using the strategy, we conducted training on FEWS NET remote sensing products for agro-climatological analysis, which focused on technical interpretation and analysis of the remote sensing and modeled products, eg, CHIRPS, RFE2, CHIRTS, GFS, NDVI, GeoCLIM and GeoGLAM. Scientists from USGS FEWS NET program delivered the training to mid-level managers and decision makers. We also carried out on-the-job trainings on wheat mapping using multi-sensor EO data for co-development of methodologies and implementation on sustainable basis. In this presentation, we will also present the lesson learned from capacity building efforts at SERVIR-HKH and how we envision the best practices for other SERVIR hubs.

  15. Guardrails for use on historic bridges: volume 2--bridge deck overhang design.

    DOT National Transportation Integrated Search

    2016-11-01

    Bridges that are designated historic present a special challenge to bridge engineers whenever rehabilitation work or improvements are : made to the bridges. Federal and state laws protect historically significant bridges, and railings on these bridge...

  16. New ideas in asthma and allergy research: creating a multidisciplinary graduate school

    PubMed Central

    Björkstén, Bengt; Graninger, Göran; Ekman, Gunilla Jacobsson

    2003-01-01

    The spring term of 2001 saw the start of a new, unique graduate research training program at the Centre for Allergy Research at the Karolinska Institutet in Stockholm, Sweden. The program was created to bridge the gaps between basic, clinical, social, and behavioral sciences and to establish a global approach to the study of asthma and allergy. A reflection, two years on, discusses the strategies that are key to this model’s success and the challenges in introducing a multidisciplinary research program. PMID:12975463

  17. A Quasi-Solid-State Li-Ion Capacitor Based on Porous TiO2 Hollow Microspheres Wrapped with Graphene Nanosheets.

    PubMed

    Wang, Faxing; Wang, Chun; Zhao, Yujuan; Liu, Zaichun; Chang, Zheng; Fu, Lijun; Zhu, Yusong; Wu, Yuping; Zhao, Dongyuan

    2016-12-01

    The quasi-solid-state Li-ion capacitor is demonstrated with graphene nanosheets prepared by an electrochemical exfoliation as the positive electrode and the porous TiO 2 hollow microspheres wrapped with the same graphene nanosheets as the negative electrode, using a Li-ion conducting gel polymer electrolyte. This device may be the key to bridging the gap between conventional lithium-ion batteries and supercapacitors, meanwhile meeting the safety demands of electronic devices. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Synthetic study toward the misassigned (±)-tronoharine.

    PubMed

    Zhong, Xue; Li, You; Zhang, Jing; Han, Fu-She

    2015-02-06

    The synthesis of a pentacyclic indole compound corresponding to the core structure of the misassigned indole alkaloid, tronoharine (1), is presented. The key reactions were a formal [3 + 3] cycloaddition of an indol-2-yl carbinol with an azadiene for the construction of the 6/5/6/6 tetracyclic system containing an all-carbon quaternary center and an intramolecular substitution reaction of an amine and a triflate for the creation of the bridged azepine ring. In addition, some other interesting transformations discovered during the synthetic studies are also discussed.

  19. German wine in an American bottle: the spread of modern psychiatry in China, 1898-1949.

    PubMed

    Li, Wenjing; Schmiedebach, Heinz-Peter

    2015-09-01

    Modern psychiatry was first introduced to mainland China around 1900 by Western missionaries. By 1949 the field had developed gradually as a result of contact with Western psychiatry and especially its American practitioners. This paper analyses the role played by key individuals and events in this process in the years prior to 1949. It argues that modern psychiatry was introduced to China through a process of cultural adaptation in which the USA served as a bridge for German thought. © The Author(s) 2015.

  20. Airway mechanics and methods used to visualize smooth muscle dynamics in vitro.

    PubMed

    Cooper, P R; McParland, B E; Mitchell, H W; Noble, P B; Politi, A Z; Ressmeyer, A R; West, A R

    2009-10-01

    Contraction of airway smooth muscle (ASM) is regulated by the physiological, structural and mechanical environment in the lung. We review two in vitro techniques, lung slices and airway segment preparations, that enable in situ ASM contraction and airway narrowing to be visualized. Lung slices and airway segment approaches bridge a gap between cell culture and isolated ASM, and whole animal studies. Imaging techniques enable key upstream events involved in airway narrowing, such as ASM cell signalling and structural and mechanical events impinging on ASM, to be investigated.

  1. Building bridges between cellular and molecular structural biology.

    PubMed

    Patwardhan, Ardan; Brandt, Robert; Butcher, Sarah J; Collinson, Lucy; Gault, David; Grünewald, Kay; Hecksel, Corey; Huiskonen, Juha T; Iudin, Andrii; Jones, Martin L; Korir, Paul K; Koster, Abraham J; Lagerstedt, Ingvar; Lawson, Catherine L; Mastronarde, David; McCormick, Matthew; Parkinson, Helen; Rosenthal, Peter B; Saalfeld, Stephan; Saibil, Helen R; Sarntivijai, Sirarat; Solanes Valero, Irene; Subramaniam, Sriram; Swedlow, Jason R; Tudose, Ilinca; Winn, Martyn; Kleywegt, Gerard J

    2017-07-06

    The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

  2. Diaminophosphine oxide ligand enabled asymmetric nickel-catalyzed hydrocarbamoylations of alkenes.

    PubMed

    Donets, Pavel A; Cramer, Nicolai

    2013-08-14

    Chiral trivalent phosphorus species are the dominant class of ligands and the key controlling element in asymmetric homogeneous transition-metal catalysis. Here, novel chiral diaminophosphine oxide ligands are described. The arising catalyst system with nickel(0) and trimethylaluminum efficiently activates formamide C-H bonds under mild conditions providing pyrrolidones via intramolecular hydrocarbamoylation in a highly enantioselective manner with as little as 0.25% mol catalyst loading. Mechanistically, the secondary phosphine oxides behave as bridging ligands for the nickel center and the Lewis acidic organoaluminum center to give a heterobimetallic catalyst with superior reactivity.

  3. Identification of key residues for protein conformational transition using elastic network model.

    PubMed

    Su, Ji Guo; Xu, Xian Jin; Li, Chun Hua; Chen, Wei Zu; Wang, Cun Xin

    2011-11-07

    Proteins usually undergo conformational transitions between structurally disparate states to fulfill their functions. The large-scale allosteric conformational transitions are believed to involve some key residues that mediate the conformational movements between different regions of the protein. In the present work, a thermodynamic method based on the elastic network model is proposed to predict the key residues involved in protein conformational transitions. In our method, the key functional sites are identified as the residues whose perturbations largely influence the free energy difference between the protein states before and after transition. Two proteins, nucleotide binding domain of the heat shock protein 70 and human/rat DNA polymerase β, are used as case studies to identify the critical residues responsible for their open-closed conformational transitions. The results show that the functionally important residues mainly locate at the following regions for these two proteins: (1) the bridging point at the interface between the subdomains that control the opening and closure of the binding cleft; (2) the hinge region between different subdomains, which mediates the cooperative motions between the corresponding subdomains; and (3) the substrate binding sites. The similarity in the positions of the key residues for these two proteins may indicate a common mechanism in their conformational transitions.

  4. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit or...

  5. 78 FR 45863 - Drawbridge Operation Regulation; Willamette River at Portland, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... operating schedule that govern four Multnomah County bridges: The Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge, mile 13.1, all crossing the... the Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and...

  6. 77 FR 43164 - Drawbridge Operation Regulation; Willamette River, Portland, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... schedule that governs four Multnomah County bridges: The Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge, mile 13.1, all crossing the..., mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge...

  7. 47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit or...

  8. Simple model of cable-stayed bridge deck subjected to static wind loading

    NASA Astrophysics Data System (ADS)

    Kang, Yi-Lung; Wang, Yang Cheng

    1997-05-01

    Cable-stayed bridges have been known since 18th century with aesthetics design. The structural system and the structural behavior are significantly different from those of continuous bridges. Compared to continuous bridge, cable- stayed bridges have more flexure bridge deck than those of continuous bridges.On the other hand, cable-stayed bridges have less stiffness to resist wind loading especially for lateral loads. The first considering of bridge engineering is safety. In 1940's, Tacoma Narrows Suspension Bridge destroyed by wind loading is a good example even though it is not a cable-stayed bridge. After the bridge was destroyed, a lot of research articles have been published regarding cable supported bridge subjected to wind loading. In recent days, high strength materials have been served. The bridge engineers use the advantages to expand the span length of cable-stayed bridges. Due to the span length increased and the use of high strength materials, cable- stayed bridges have more significant nonlinear behavior subjected to wind loading. In this paper, a slice bridge deck of cable-stayed bridge connected to internal support cables is considered. The deck has been considered to be subjected to lateral static wind loading. Since cables can not take compressive force, the deck has strongly nonlinear behavior even though the materials are linear elastic. Several primary load combinations have ben considered in this paper such as the bridge deck supposed to be moved horizontally without rotation or the bridge deck supposed to be moved horizontally with rotational deformation. The mathematical formulas and the numerical solutions are found and represented in graphical forms. The results can be provided to bridge designers and researchers for further study of this type of structure subjected to wind loading.

  9. Dynamic response for structural health monitoring of the Penang (I) cable-stayed bridge

    NASA Astrophysics Data System (ADS)

    Mohammed, M. I.; Sulaeman, E.; Mustapha, F.

    2017-03-01

    The paper discusses the dynamic response of the Penang (I) cable stayed bridge structure under various moving load representing typical traffic load of the bridge. The bridge has a total span of 440 m excluding the transition bridge that assumed to be not connected structurally to the main bridge structure. The bridge that links the fast growing Pinang Island and the Malaysian Mainland Peninsula has been known to be fully utilized which leads to the construction of Penang (II) bridge and now the third one. Due to highly traffic use of the bridge that may lead to reduction of the bridge design life, the dynamic response of the bridge becomes important to predict critical part of the bridge structure elements including the main girder and the 144 stay cables. The present study reveals that, due to flexible nature of the cable stayed bridge, the moving load that interacts with the natural dynamic characteristics of the bridge, gives significant stress increment compare to proportional static load especially when the moving load is un-symmetric. For this reason, several classes of typical vehicle passing the bridge with various vehicle speeds are investigated to demonstrate their effect on the bridge displacement, internal forces and stresses. The results can be used for further fatigue assessment of the bridge.

  10. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the designated...

  11. 47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the designated...

  12. Vibration analysis of the Second Saikai Bridge—a concrete filled tubular (CFT) arch bridge

    NASA Astrophysics Data System (ADS)

    Yoshimura, Mistuhiro; Wu, Qingxiong; Takahashi, Kazuo; Nakamura, Shozo; Furukawa, Kazuyoshi

    2006-02-01

    Concrete-filled steel tubular (CFT) arch bridges have been rapidly developing in China since 1990. Research has focused on the static behavior, thermal stress and erection technique, however, and there has been very little research of natural vibrations and dynamic responses of these bridges. Japan's first CFT arch bridge in highway bridges, the Second Saikai Bridge, is now under construction in Nagasaki Prefecture. Furthermore, this bridge has a pedestrian bridge that is suspended under the girder, which is rare. Therefore, the natural vibration properties are examined, and the influence of pedestrian bridge structure on the natural vibration of main bridge is discussed first. Response analysis under a moving vehicle and pedestrian is carried out, and the response characteristics and response level are clarified. The natural vibrations and responses are compared to those of CFT arch bridges that have been constructed in China. Results show the fine performance of both main bridge and pedestrian bridge of the Second Saikai Bridge.

  13. Unexpected Connections between Humidity and Ion Transport Discovered Using a Model to Bridge Guard Cell-to-Leaf Scales.

    PubMed

    Wang, Yizhou; Hills, Adrian; Vialet-Chabrand, Silvere; Papanatsiou, Maria; Griffiths, Howard; Rogers, Simon; Lawson, Tracy; Lew, Virgilio L; Blatt, Michael R

    2017-11-01

    Stomatal movements depend on the transport and metabolism of osmotic solutes that drive reversible changes in guard cell volume and turgor. These processes are defined by a deep knowledge of the identities of the key transporters and of their biophysical and regulatory properties, and have been modeled successfully with quantitative kinetic detail at the cellular level. Transpiration of the leaf and canopy, by contrast, is described by quasilinear, empirical relations for the inputs of atmospheric humidity, CO 2 , and light, but without connection to guard cell mechanics. Until now, no framework has been available to bridge this gap and provide an understanding of their connections. Here, we introduce OnGuard2, a quantitative systems platform that utilizes the molecular mechanics of ion transport, metabolism, and signaling of the guard cell to define the water relations and transpiration of the leaf. We show that OnGuard2 faithfully reproduces the kinetics of stomatal conductance in Arabidopsis thaliana and its dependence on vapor pressure difference (VPD) and on water feed to the leaf. OnGuard2 also predicted with VPD unexpected alterations in K + channel activities and changes in stomatal conductance of the slac1 Cl - channel and ost2 H + -ATPase mutants, which we verified experimentally. OnGuard2 thus bridges the micro-macro divide, offering a powerful tool with which to explore the links between guard cell homeostasis, stomatal dynamics, and foliar transpiration. © 2017 American Society of Plant Biologists. All rights reserved.

  14. A new energy-efficient control approach for astronomical telescope drive system

    NASA Astrophysics Data System (ADS)

    Zhou, W.; Wang, Y.

    2012-12-01

    Drive control makes the astronomical telescope accurately tracking celestial bodies in spite of external and internal disturbances, which is a key technique to the performance of telescopes. In this paper, we propose a nonlinear ad, aptive observer based on power reversible approach for high precision telescope position tracking. The nonlinear adaptive observer automatically estimates the disturbances in drive system, and the observed value is applied to compensate for the real disturbances. With greatly reduced disturbances, the control precision can be evidently improved. In conventional drive control, the brake device is often used to slow down the reaction wheel and may waste enormous energy. To avoid those disadvantages, an H-bridge is put forward for wheel speed regulation. Such H-bridge has four independent sections, and each section mainly consists of a power electronic switch and an anti-parallel diode. During the period of the mount slowing down, the armature current of drive motor goes through the two path-wise diodes to charge the battery. Thus, energy waste is avoided. Based on the disturbance compensation, an optimal controller is designed to minimize an evaluation function which is made up of a weighted sum of position errors and energy consumption.The outputs of the controller are applied to control the H-bridge. Simulations are performed in MATLAB language. The results show that high precision control can be obtained by the proposed approach. And the energy consumption will be remarkably reduced.

  15. Mapping evidence of interventions and strategies to bridge the gap in the implementation of the prevention of mother-to-child transmission of HIV programme policy in sub-Saharan countries: A scoping review.

    PubMed

    Ngidi, Wilbroda H; Naidoo, Joanne R; Ncama, Busisiwe P; Luvuno, Zamasomi P B; Mashamba-Thompson, Tivani P

    2017-05-29

    Prevention of mother-to-child transmission (PMTCT) of HIV is a life-saving public health intervention. Sub-Saharan African (SSA) countries have made significant progress in the programme, but little is known about the strategies used by them to eliminate mother-to-child transmission of HIV. To map evidence of strategies and interventions employed by SSA in bridging the implementation gap in the rapidly changing PMTCT of HIV programme policy. Electronic search of the databases MEDLINE, PubMed and SABINET for articles published in English between 2001 and August 2016. Key words included 'Sub-Saharan African countries', 'implementation strategies', 'interventions to bridge implementation gap', 'prevention of mother-to-child transmission of HIV' and 'closing implementation gap'. Of a total of 743 articles, 25 articles that met the inclusion criteria were included in the study. Manual content analysis resulted in the identification of three categories of strategies: (1) health system (referral systems, integration of services, supportive leadership, systematic quality-improvement approaches that vigorously monitors programme performance); (2) health service delivery (task shifting, networking, shared platform for learning, local capacity building, supportive supervision); as well as (3) community-level strategies (community health workers, technology use - mHealth, family-centred approaches, male involvement, culturally appropriate interventions). There are strategies that exist in SSA countries. Future research should examine multifaceted scientific models to prioritise the highest impact and be evaluated for effectiveness and efficiency.

  16. 49 CFR 237.111 - Review of bridge inspection reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Review of bridge inspection reports. 237.111... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.111 Review of bridge inspection reports. Bridge inspection reports shall be reviewed by railroad bridge supervisors and railroad...

  17. 49 CFR 237.111 - Review of bridge inspection reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Review of bridge inspection reports. 237.111... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.111 Review of bridge inspection reports. Bridge inspection reports shall be reviewed by railroad bridge supervisors and railroad...

  18. Field performance of timber bridges. 7, Connell Lake stress-laminated deck bridge

    Treesearch

    L. E. Hislop; M. A. Ritter

    The Connell Lake bridge was constructed in early 1991 on the Tongass National Forest, Alaska, as a demonstration bridge under the Timber Bridge Initiative. The bridge is a stress-laminated deck structure with an approximate 36-ft length and 18-ft width and is the first known stress-laminated timber bridge constructed in Alaska. Performance of the bridge was monitored...

  19. 25. VIEW OF McGREGOR BRIDGE (18811936), CROSSING THE MERRIMACK RIVER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. VIEW OF McGREGOR BRIDGE (1881-1936), CROSSING THE MERRIMACK RIVER AT BRIDGE STREET, LOOKING SOUTHEAST. NORTH ELEVATION OF DOUBLE-DECKED, THREE-SPAN DOUGLAS PATENT PARABOLIC IRON TRUSS ERECTED BY CORRUGATED METAL COMPANY (BERLIN IRON BRIDGE COMPANY, BERLIN, CT) From 'Bridge Street Bridge', photographer and date unknown. - Notre Dame Bridge, Spanning Merrimack River on Bridge Street, Manchester, Hillsborough County, NH

  20. Improving Bridging from Informatics Practice to Theory.

    PubMed

    Lehmann, C U; Gundlapalli, A V

    2015-01-01

    In 1962, Methods of Information in Medicine ( MIM ) began to publish papers on the methodology and scientific fundamentals of organizing, representing, and analyzing data, information, and knowledge in biomedicine and health care. Considered a companion journal, Applied Clinical Informatics ( ACI ) was launched in 2009 with a mission to establish a platform that allows sharing of knowledge between clinical medicine and health IT specialists as well as to bridge gaps between visionary design and successful and pragmatic deployment of clinical information systems. Both journals are official journals of the International Medical Informatics Association. As a follow-up to prior work, we set out to explore congruencies and interdependencies in publications of ACI and MIM. The objectives were to describe the major topics discussed in articles published in ACI in 2014 and to determine if there was evidence that theory in 2014 MIM publications was informed by practice described in ACI publications in any year. We also set out to describe lessons learned in the context of bridging informatics practice and theory and offer opinions on how ACI editorial policies could evolve to foster and improve such bridging. We conducted a retrospective observational study and reviewed all articles published in ACI during the calendar year 2014 (Volume 5) for their main theme, conclusions, and key words. We then reviewed the citations of all MIM papers from 2014 to determine if there were references to ACI articles from any year. Lessons learned in the context of bridging informatics practice and theory and opinions on ACI editorial policies were developed by consensus among the two authors. A total of 70 articles were published in ACI in 2014. Clinical decision support, clinical documentation, usability, Meaningful Use, health information exchange, patient portals, and clinical research informatics emerged as major themes. Only one MIM article from 2014 cited an ACI article. There are several lessons learned including the possibility that there may not be direct links between MIM theory and ACI practice articles. ACI editorial policies will continue to evolve to reflect the breadth and depth of the practice of clinical informatics and articles received for publication. Efforts to encourage bridging of informatics practice and theory may be considered by the ACI editors. The lack of direct links from informatics theory-based papers published in MIM in 2014 to papers published in ACI continues as was described for papers published during 2012 to 2013 in the two companion journals. Thus, there is little evidence that theory in MIM has been informed by practice in ACI.

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