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  1. EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion

    SciTech Connect

    Huang, Er-Wen; Xue, Sheng-Jiang; Li, Xiao-Yan; Xu, Suo-Wen; Cheng, Jian-Ding; Zheng, Jin-Xiang; Shi, He; Lv, Guo-Li; Li, Zhi-Gang; Li, Yue; Liu, Chang-Hui; Chen, Xiao-Hui; Liu, Hong; Li, Jie; Liu, Chao

    2014-05-02

    Highlights: • Levels of EEN expression paralleled with the rate of cell proliferation. • EEN was involved in the proliferation and survival of multiple myeloma (MM) cells. • EEN regulated the activity of IGF-1-Akt/mTOR pathway. • EEN regulated proliferation and survival of MM cells by enhancing IGF-1 secretion. - Abstract: The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 to S phase by regulating cyclin-dependent kinases (CDKs) pathway, and delayed cell apoptosis via Bcl2/Bax-mitochondrial pathway. Mechanistically, we found that EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway. Exogenous IGF-1 overcame the phenotype of EEN depletion, while IGF-1 neutralization overcame that of EEN over-expression. Collectively, these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. Therefore, EEN may represent a potential diagnostic marker or therapeutic target for multiple myeloma.

  2. Decision Making in a Dynamic Situation: The Effect of Time Restrictions and Uncertainty (Beslisgedrag in een Dynamische Situatie: Het Effect van Tijdsdruk en Onzekerheid)

    DTIC Science & Technology

    1994-02-18

    genomen beslissingen op de omngeving nagaan en eventueel een ingeslagen koers wijzigen. Vergeleken met een statische taak krijgt tijdsdruk een andere...beslisser de effecten van g( Ormen beslissingen op de omngeving nagaan en eventueel een ingeslagen koers wijzigen. Vergeleken met een statische taak

  3. An Exploratory Study of the Interpretation of Logical Operators in Database Querying (Een Verkennende Studie van de Interpretatie van Logische Operatoren bijhet Bevragen van een Database)

    DTIC Science & Technology

    1991-03-22

    nn i 3 CONTENTS Page SUMMARY 5 SAMENVATTING 6 1 INTRODUCTION 7 2 METHOD 11 2.1 Subjects 12 2.2 Stimuli 12 2.3 Procedure 14 3 RESULTS 15 3.1 Latency...SAMENVATITING Het gebruik van logische operatoren in vraagtalen wordt beschouwd als een belangrijke bron van gebruikersproblemen bij het bevragen van een...verwerkingscomponenten werden getest. 7 1 INTRODUCTION Database management systems (DBMSs) are now widely used for structuring and storing textual information in

  4. ATHENA: De Combinatie van een Helderheidsversterker en Thermische Kijker met Kleurweergave (ATHENA: The Combination of a Brightness Amplifier and Thermal Viewer With Color)

    DTIC Science & Technology

    2007-08-01

    A329 27 / 46 Het ATHENA systeem Het ATHENA systeem als geheel bestaat uit de combinatie van een warmtebeeld camera en een digitale ...camerasysteem is er ook een digitale fotocamera geplaatst. TNO-rapport | TNO-DV 2007 A329 29 / 46 3.1.1 Camera’s Het ATHENA camerasysteem bestaat...uit een Lion Advance infrarood (warmtebeeld of WB) camera (Thales Optronics B.V.) en een digitale helderheidsversterker (HVCCD. zie figuur 7). De

  5. Meetopstelling van een Gepulste CO2 Laser Afstandsmeter met Heterodyne Detectie (Experimental Set-Up for a Pulsed CO2 Laser Range-Finder with Heterodyne Detection)

    DTIC Science & Technology

    1990-08-01

    voor een staande golf om te resoneren via een andere weg dan door het midden van de cavity. Meestal kan door het verdraaien van het tralie hier iets aan...gedaan worden. Mogelijkerwijs speelt ook hier het tralie dus een rol. Tot slot is gebleken dat de RF laser, die gevoed wordt door een wissel- spanning...laser. Bij beide lasers is het mogelijk door middel van hat verstellen van een tralie een lijn uit bet C0 2-spectrum in de 9 en 10 pm band te selekteren

  6. REMOTE LAND MINE(FIELD) DETECTION. An Overview of Techniques (DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND. Een Overzicht van de technieken),

    DTIC Science & Technology

    1994-09-01

    systeem voor mijnen of mijnenvelden essentieel. De basis principes en sterke en zwakke punten van "real time" mijnen detectie met visuele, nabij...tweede deel van het rapport worden aanbevelingen gegeven voor een toekomstig systeem voor de detectie van mijnen. Deze aanbevelingen zijn gebaseerd...multi-sensor systeem voor op een voertuig. Dit is gebaseerd op de interesse die de "Genie" toont voor een dergelijk systeem , de kosten van een

  7. Cognitie Versus Sensatie: Een Paradigma Voor Herorieentatie (Cognition Versus Sensation: A Paradigm for Reorientation)

    DTIC Science & Technology

    1989-07-01

    EEN PARADIGMA VOOR HERORIWNATIE 2 L.C. Boer 0 DTI ELECTE FEB 16190 WO IDISThMATO .&TfAqMnT A 1 Approved for PWbli reg 90o 02 15 053 Nederiandse...5 39 77eloonr 03463 -5 62 11 IZF 1989-20 ’COGNITIE VERSUS SENSATIE: EEN PARADIGMA VOOR HERORIENTATIE L.C. Boer 20 Niels uid daze ungave mag nworden...Dist I Special 5 Rapport nr.: IZF 1989-20 Titel: Cognitie versus sensatie: eon paradigma voor heroridntatie Auteur: Dr. L.C. Boer Instituut: Instituut

  8. Eisen voor Buitenbeelden van Voertuigsimulatoren: Een Literatuurstudie (Use of Exterior Pictures in Vehicle Simulators: A Literature Survey)

    DTIC Science & Technology

    1991-06-01

    afstand van bet traject van bet voertuig (Waidram, 1985), zoals onderbroken wegbelijning of bomen langs, de weg. Voor bet waarnemen van koers en...betroffen het op constante boogte houden en een vaste koers bandbaven bij random verstoringen. Een beeldvertraging van 100 ms zou ook geen belangrijk effect...Voor onderzoek naar, en training van, interacties tussen weggebmuikers is het echter belangrijk omn zowel koers als sneiheid van U6n of meer

  9. A Decision Support System for Manpower Planning (Een Beslissingsondersteunend Systeem voor Personeels-Planning

    DTIC Science & Technology

    1990-10-01

    over bet feitelijke ge- bruik van bet beslissingsondersteunende systeem . TNO report Page 4 ABSTRACT 2 SAMENVATTING 3 CONTENTS 4 SURVEY OF FIGURES 5 1...manpower planning and policy analysis. We describe the decision making context in which the system can be used and give a survey of its contents and its...Availability Codes Avail and/or Dist Speoial 7NO report Page 3 rapport no. FEL-90-B300 titel Een beslissingsondersteunend systeem voor personeels

  10. A Description of Preliminary Cook-off Experiment of Type IV Pipes Filled with TNT (Een Beschrijving van de Inleidende Cook-off Experimenten met TNT gevulde TYpe IV Buizen)

    DTIC Science & Technology

    1993-04-01

    houden is een speciale houder ontwikkeld zoals aangegeven in figuur 3. 1: Buiswand 2: Teflon ster 3: Stolen capilair (1.2mm) 4: Thermokoppels (4 stuks ) 5...een restant van de buis vast. Ook was te zien dat de dop een stuk van de bwis geschoven was. De buis had geen blauw- kicuring ondergaan! 27-09-9 1: Het

  11. Changes in fecal microbiota and metabolomics in a child with juvenile idiopathic arthritis (JIA) responding to two treatment periods with exclusive enteral nutrition (EEN).

    PubMed

    Berntson, Lillemor; Agback, Peter; Dicksved, Johan

    2016-06-01

    The microbiome and immune system of the digestive tract are highly important in both health and disease. Exclusive enteral nutrition (EEN) is a common anti-inflammatory treatment in children with Crohn's disease in the European countries, and the mechanism is most likely linked to changes in the intestinal microbiome. In the present study, EEN was given in two treatment periods several months apart to a patient with very severe, disabling juvenile idiopathic arthritis (JIA), with a remarkable clinical response as the result. The aim of the present study was to study how the EEN treatment influenced the microbiome and metabolome of this patient. Fecal samples from before, during, and between treatments with EEN were studied. The microbiome was analyzed by sequencing of 16S rRNA amplicons using Illumina MiSeq, and the metabolome was analyzed using nuclear magnetic resonance. The microbiome changed markedly from treatment with EEN, with a strong reduction of the Bacteroidetes phylum. Metabolic profiles showed clear differences before, during, and between treatment with EEN, where butyrate, propionate, and acetate followed a cyclic pattern with the lowest levels at the end of each treatment period. This patient with JIA showed remarkable clinical improvement after EEN treatment, and we found corresponding changes in both the fecal microbiome and the metabolome. Further studies are needed to explore the pathophysiological role of the intestinal canal in children with JIA.

  12. Analysis of Adaptive Team Concept through Simulation Models: A Survey (toetsing van adaptieve teamconcepten door middel van simulatiemodellen: een verkenning)

    DTIC Science & Technology

    2006-02-01

    beschikt dat ondieptes kan vaststellen dan zou op basis van ’vaart en koers ’ de mogelijkheid van ’grounding’ kunnen worden vastgesteld. Op een...omgeving aanwezig zijn hun kenmerken, zoals: afstand, hoogte, snelheid, koers , radartype, verandering van gedrag, informatie die beschikbaar komt (wat

  13. Is Choice Accuracy Related to Information Search Patterns (Is de Juistheid van een Keuze Gerelateerd aan het Informatiezoekpatrron)?

    DTIC Science & Technology

    1991-07-29

    incest variabele zoekgedrag. In alle complexiteitscondities bleef echter de juistheid van bet gekozen alternatief constant. Een plausibele verkiaring...W04had mom ct Oas a1e hr , Mor ib to oceur then 6 others (e.g. .68, .1Z .05 and .15). The sinulations showed that depending on the choice environment

  14. Mentale Inzetbaarheid van Teams: Ontwikkeling van een Moden van Teamfunctioneren als Module voor SCOPE (Mental Readiness of Teams - Development of a Team Model as Module for SCOPE)

    DTIC Science & Technology

    2007-04-01

    De groepscomniandant wordt dlaarbij een belangrijke rol toegedicht. Op bet individuele niveau wordt verder aan enthousiasme , motivatie en karakter...cohesie naar voren. Daarnaast wordt er veel waarde gehecht aan training en ervaring (los van teamleeftijd), enthousiasme , motivatie en karakter. Dit...zijn. Gaat hij de ervaringen van de groep uit de weg zal hij op 3 kome&n te staan. * Een koppige/eigenwijze gcdt kan de effectiviteit en enthousiasme

  15. Ex ante Implementatietoetsing van Beleid, Een Methodiek Gebaseerd op Synergie Tussen Risicomanagement en Verandermanagement (Ex Ante Test for Policy Implementation - A Method Based Upon Synergy Between Risk Management an Change Management)

    DTIC Science & Technology

    2006-12-01

    management) en specifieke middelen ( geld , ingehuurde capaciteit) die er tijdens het implementeren nog waren zijn er vaak niet meer. Tegelijkertijd komnen...zaken als bet beschikbaar stellen van middelen voor de verandering (tijd. geld , capaciteit); het ontwikkelen van nieuwe competenties en vaardigbeden...verlies uit te drukken in geld , of een explosie in een chem-ische installatie in aantal doden. Echter. vaak is een gevolg moeilijker te kwantificeren. zoals

  16. A 27 Channels, 1 MHz Fibre-Optic Measuring System (Een 27-Kannaals, 1 MHz Optisch Meetsysteem)

    DTIC Science & Technology

    1993-03-01

    het meetsysteem liggen. Als kantelpunt van het laagdoorlaat filter is wtceindelijk een frequentie van 3,6 MHz gekozeii; deze waarde blijkt optimaal te...Optical Output Logic "I" Logic Ŕ" optical Port Core Diameter >2 4V ɘ 4V @ 1 6mA siniK 200Pm Overvoltage Protection Peek Wavelength WX +7V maximum 820nmj

  17. Vrouwen bij de Koninklijke Landmacht: Een Onderzoek naar de Maatregelen die het Behoud en de Doorstroom van Vrouwelijke Militairen Verbeteren (Women in the Royal Netherlands Army: Measures for Retention and Career Development)

    DTIC Science & Technology

    2007-02-01

    op bet werk befnvloedt de werkbeleving en tevredenbeid van werknemers. Ret werk is immers niet alleen een manier om geld te verdienen. maar ook een...arbeidskracht. Als de organisatie daadwerkelijk belang hecht aan combinatiemnogelijkheden van werk en priv6, moet daar ook tijd en geld voor vrijgemaakt

  18. De Ontwikkeling van een PBPK Model voor VX; Stand van Zaken V013-813 en 207C (The Development of a PBPK Model for VX: Status Report)

    DTIC Science & Technology

    2006-02-01

    bet ontbreken van voldoende validatic- gegevens zoals de toxicokinetiek in diverse relevante species, zoals de cavia en de marmoset , maar ook van de...hydrolysesneiheid van de isomeren De enzymatische hydrolyse van VX in weefselhomogenaat afkomstig van onder andere cavia’s, marmoset , rhesusaap en een stukie...Langenberg, J.P. en Benschop, H.P., Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets

  19. Building GIS on Top of the Open DBMS ’Postgres’ (Het Bouwen van een GIS op Basis van het Open DBMS ’Postgres’)

    DTIC Science & Technology

    1991-08-01

    solution based on the extendable database management system Postgres, in which thematic and spatial data are stored together. The contents of this report...EXTENDABLE DATABASE MANAGEMENT SYSTEM "POSTGRES. IN WHICH THEMATIC AND SPATIAL DATA ARE STORED TOGETHER. THE CONTENTS OF THIS REPORT WAS PRESENTED AT THE...hebben en duale architectwr: de themnatisdie informatie is opgeslagen in een relationeel database management systeem en de ruimtekike infor- matie is

  20. Beslisbevoegdheden van de Uitgestegen Soldaat. Deel B: Verbetering van Situational Awareness Met Behulp van de Soldier Digital Assistant in een Gesimuleerde Omgeving (Authority and Responsbility of the Dismounted Soldier. Part B. Improving the Situational Awareness using the Soldier Digital Assistant in a Simulated Environment)

    DTIC Science & Technology

    2007-04-01

    omn een bepaalde handeling of een scenario te simuleren. Het voordeel van virtuele omngevingen is dat ze minder tijd en geld kosten om op te zetten...Met name door bet gebruik van bestaande middelen kon veel tijd en geld bespaard worden. Zo is de omngeving ontwikkeld in de bestaande ’Unreal’ game

  1. Simulation of a Shot from the Otomelara 76/62 with Pisces-2delk Gain Burning (Simulatie van een schot van de Otomelara 76/62 met pisces-2delk Gain Burning).

    DTIC Science & Technology

    1992-09-01

    In dit geval is daar de covolume vergelijking (ook wel bekend als Noble-Abet vergelijk~ing) voor gebruikt. Deze subroutine hoeft niet gedeclareerd te...maximale theoretische druk 232.6 MPa force 915.2 Id/kg molaire massa kruitgassen 23.2 g/rnol covolume kruitgassen 1.065 cm3/g gamma (cd,/c) 1.258 soortelijke...gehouden worden met bet covolume van de kruitgassen, de onstekcing (beide bekend) en warmteverliezen naar de born. Van dit laatste kan een redelijke

  2. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity

    PubMed Central

    Spelman, Kevin; Depoix, Delphine; McCray, Megan; Mouray, Elisabeth; Grellier, Philippe

    2010-01-01

    Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there is no data on active constituents or most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC50s of 16.5 μg/mL and 41.4 μg/mL on Plasmodium falciparum strain PFB and IC50s of 5.8 μg/mL and 16.3 μg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5 mg/kg and 50 mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50 mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum. PMID:22692989

  3. Secondary Education in Africa: Strategies for Renewal. World Bank Presentations at the UNESCO/BREDA-World Bank Regional Workshop on the Renewal of Secondary Education in Africa (Mauritius, Africa, December 2001). Africa Region Human Development Working Paper Series.

    ERIC Educational Resources Information Center

    Mastri, Lawrence, Ed.

    During the last 3 decades secondary education has become universal in most industrialized countries. Sub-Saharan African countries face special challenges to benefit from this international trend. The gap between these countries and the rest of the world in coverage, quality, and relevance of secondary education is widening. To address these…

  4. A Comparison of Decision Making Behaviour in a Static and a Dynamic Task Environment as a Function of Time Pressure (Een Vergelijking van Beslisgedrag in een Statische en een Dynamische Taakomgeving Als Functie van Tijdsdruk)

    DTIC Science & Technology

    1994-05-20

    Technische Menskunde’, Soesterberg MANAGEMENT UTTREKSEL Bij het onderzoek naar beslissen wordt de laatste jaren meer aandacht besteed aan de invioed van het...Technische Menskunde’, Soesterberg MANAGEMENT UI’FTREKSEL Bij het onderzoek naar beslissen wordt de Iaatste jaren meer aandacht besteed aan de invloed...feedback over de algemene toestand van het systeem . Daarori _n verwacht worden dat de uiteindelij- ke prestaties, in termen van uitkomsten, beter zijn in

  5. Navigation in Unfamiliar Cities: A Review of the Literature and a Theoretical Framework (Navigeren in Onbekende Steden: Een Literatuurstudie en een Theoretisch Kader)

    DTIC Science & Technology

    1989-10-02

    do not enter an unfamiliar city as a tabula rasa : they have extensive knowledge of cities they once have visited, and thus have certain expectations...begin to play an increasingly important role , such that they automatically retrieve the appropriate choice of route from the long-term memory knowledge

  6. Op weg naar een didactiek voor natuurkunde-experimenten op afstand : Ontwerp en evaluatie van een via internet uitvoerbaar experiment voor leerlingen uit het voortgezet onderwijs

    NASA Astrophysics Data System (ADS)

    Engelbarts, M. B. A.

    2009-02-01

    The subject of this thesis is a developmental study on “remote experimenting” in education. It concerns the development of a remote experiment that enables pre-university students to carry out a physics experiment at a distance via the internet. Remote experiments can offer several (practical) benefits when compared to conventional experiments but the desire to exploit these benefits put special demands on the design of the experiment, since the students might be conducting the experiment without a teacher in the vicinity. As a consequence of these demands it was decided to focus on exploring the possibilities and problems of remote experiments conducted in the absence of a teacher. The research was carried out in two cycles and focused on the development of a remote experiment that could be conducted autonomously by pre-university students to measure the speed of light in several media. This should answer the global question: What should a technically, as well as didactically, well-functioning remote experiment look like? The first cycle had an explorative character. It showed that technically the experiment already functioned quite well. However, many problems were observed concerning the content, and the way the students were tackling it. This led to two categories of recommendations. Concerning the content, the material should aim at making the students more aware of what they are doing and why they are doing it and several content related problems needed to be avoided. The second category of recommendations concerned the format of the material: the design and the working method. Special attention should be paid to designing a clear structure for the website and adding interaction and control, (feedback- and reflection facilities) to activate the students and guide them through the material. In the second research cycle these recommendations were followed by designing the material within the theoretical framework of the problem posing theory. A didactical structure was designed before writing the actual lesson material for the website describing the inter-related conceptual and content-related motivational pathway of the intended teaching-learning process. The lesson material was set up in such a way that the students are repeatedly confronted with a practical problem to solve and they play an active role in developing the method of measurement. Secondly, in an attempt to compensate for the absence of the teacher and support the teaching-learning process some format elements were developed and deployed like an automated question-, and feedback system that supported the students, activated them and gave them insight into their learning process and a ‘Where-am-I’-window that showed their current position within the material. This all had led to a technically as well as didactically well functioning remote experiment in which, at a global level, the line of reasoning was made explicit and recognizable for the students, and ad a local level was build up out of well connected successive activities and required the students to adopt an active attitude.

  7. A High Repetition Rate LIDAR (En LIDAR met een Hoge Herhalingsfrequentie)

    DTIC Science & Technology

    1991-04-01

    a tungsten wire which touches only the lamp) for the ignition of the simmer mode. I The resonator of the laser has a length of 40 cm. The back mirror ...has a reflectivity of 99,9 %; the front mirror has a reflectivity of 50 %. Both mirrors are coated for 1064 am. An aluminum profile gives the...resonator sufficient mechanical rigidity against bending. A zerodur rod, embedded in araldite, has been mounted in the center of the aluminum profile for

  8. Het natuurwetenschappelijk modelleren van dynamische systemen; Naar een didactiek voor het voortgezet onderwijs

    NASA Astrophysics Data System (ADS)

    Ormel, B. J. B.

    2010-01-01

    Scientific modelling of dynamical systems; towards a pedagogy for secondary education Computer models of complex dynamical systems play a major role in science, as well as in societal debate about issues such as climate change, and insight in models and modelling is an important learning aim in science education. However, in teaching practice, it has proven difficult to give computer modelling an integrated role in the curriculum. We took a design research approach to gain insight in the pedagogy of modelling complex dynamical systems. We designed a physics course in which students constructed, evaluated and refined computer models of the climate system. Our design objectives were to get the students engaged in a meaningful modelling process, while retaining essential characteristics of the scientific modelling process. The teaching design was classroom-tested with four teachers and, after being revised, again with one teacher. The overall conclusion is that, although the models become more and more complex along the way, the content and level of the module are well within the range of pupils’ capacities. However, the evaluation of both research cycles revealed some critical problems that hindered the achievement of the teaching goals. Based on what seemed feasible as well as problematic we formulated guidelines for the designing of a modelling curriculum. It is important that modules geared at gaining authentic modelling experience only follow after the teaching of relevant and necessary content knowledge. Focussing on the scientific modelling process should not be combined with substantive content goals. Teaching the paradigmatic models of a domain may be a powerful tool to enable pupils to apply their knowledge in a variety of contexts. Developing these models and teaching pupils how to use them then coincides with teaching the regular physics concepts. We found that students find it difficult to explain behaviour in terms of ‘rules of change’. Therefore, we propose that teaching dynamics focuses on describing the rules of change in terms of differential equations, even for rather simple systems that can be described analytically. Next, we touched upon the delicate balance between guidance and freedom. While some guidance is needed to provide a sense of direction, too much guidance may also hinder insightfulness. In a directive approach in which the teacher shows an expert modelling process, pupils may develop advanced models. However, their own ideas about the system and about how to approach the problem remain unknown. In a pupil-oriented approach it is easy to underestimate the need for explicitly motivating model decisions by the pupils as well as those made by the teacher, in order to establish a truly purpose-driven process. In our tests, teachers were little inclined to let the students evaluate their own contributions, and the students were not used to it either. Thus, if students are to become independent modellers, this will affect the whole classroom culture. Also, experiencing the modelling cycle repeatedly does not guarantee that pupils become more independent modellers themselves. They would benefit from systematic reflection on modelling activities which specifies clearly what each activity should yield and how these yields are achieved.

  9. Elektrische Scheepsvoortstuwing en Supergeleiding: Een Literatuurstudie (Electric Ship Propulsion and Superconductivity: A Desk Study)

    DTIC Science & Technology

    1992-06-01

    In this report the advantages and disadvantages of electric ship propulsion compared to mechanical propulsion are discussed and the question is...superconducting propulsion system are described. Finally, future developments are discussed, conclusions are drawn and four proposals for future studies are formulated. Superconductivity, Ship Propulsion .

  10. Synthetisch Denken : Natuurwetenschappers over hun rol in een moderne maatschappij 1900-1940

    NASA Astrophysics Data System (ADS)

    Baneke, D.

    2008-06-01

    In this study, I address the advent of ‘modernity’ in Dutch culture, especially in the Interwar years, from the perspective of scientists and engineers. They were important actors in many intellectual debates, since science and technology were at the core of the cultural and societal developments of the period. The first chapter of this study describes the cultural context. At the end of the nineteenth century, many characteristics of the ‘modern age’ were increasingly considered as problematic. Scientists, philosophers, writers and artists searched for new intellectual frameworks to befit the modern world. These frameworks were highly varied, ranging from occultism (the ‘petites régions’) to strictly rational philosophical systems. However the differences were gradual rather than fundamental. Science was at the core of the discussions about the problems of modernity. It was blamed for creating many of the problems, but it was also hailed as part of the solution. The problems of modernity were also discussed by contemporary Dutch intellectuals (including scientists) throughout the first half of the twentieth century. The cultural elite of the Netherlands was highly aware of contemporary developments in neighbouring countries. However, the Dutch debate had some specific characteristics. In contrast to the Weimar Republic, culture pessimism was absent in the 1920s. This changed in the 1930s, with the economic and political crisis. The crisis gave the problems of modernity a new urgency. In reaction, the intellectual debate changed from abstract and often utopian to a more concrete level. From the cultural and political debates that started at the turn of the twentieth century, a new kind of public intellectual emerged: the expert intellectual. That is the subject of the last chapter (chapter 8). I elaborate on the tension between social engagement and scientific objectivity that is inherent in the position of intellectuals. This tension was also one of the central issues in the debates about the role of scientists in society. The intervening chapters establish the link between the cultural developments and the rise of this modern intellectual. These six chapters are divided in two sections, each focussing on a different theme in the discussions. The two sections provide two ‘routes’ from the first to the last chapter`. The first section focuses on the universities and vocational colleges. It ends with a case-study on ir. I.P. de Vooys. The second chapter describes the quest for an all-encompassing philosophical ‘synthesis’, with special attention to debates on causality and determinism. The case-study in this section is biologist H.J. Jordan. After the Second World War, many of the ideas from the Interwar period were implemented, as I describe in a short epilogue. Expert-intellectuals played a crucial role in planning the reconstruction.

  11. Satellite Applications for Military Support. Trendwatch from an EO Perspective (Satelliettoepassingen voor Militaire Ondersteuning. Trendwatch Vanuit een EO Perspectief)

    DTIC Science & Technology

    2007-03-01

    Bangladesh . Figure 3.12 True colour image of sedimentation along the coast of Bangladesh . Source: ESA. 3.8 Fires and hotbeds The detection of fires...19 3.5 Seawater temperature and soil moisture...23 3.7 Sedimentation

  12. KIBOWI: A Training Wargame for the Royal Netherlands Army (KIBOWI: Een Training Wargame voor de Koninklijke Landmacht)

    DTIC Science & Technology

    1989-12-01

    gebruik van het model heeft plaatsgevonden gedurende 1988 en 1989 voor circa 20 weken op bataljonsniveau. Ervaring in het gebruik van het prototype...representatie en eenheidsinteractie (detectie, direct vuur, etc.). TNO report Page 4 CONTENTS ABSTRACT 1 SAMENVATTING 2 CONTENTS 4 1 INTRODUCTION 6 2 THE...processes, readjusting for hardware failures, making backups, restarts, etc. 2. Database manager To create exercise databases and to facilitate and

  13. Ergonomische Evaluatie van Drie Prototypen van een Gevechtsbepak- Kingssysteem (Ergonomical Evaluation of Three Prototypes of a Military Backpack)

    DTIC Science & Technology

    1990-07-25

    M. Holewijn KINGSSYSTEEM (V) R. Heus . t d (’ JNiets uit daeze LIligave mag wre vermenlgvuldigd en/of openbaar gemaakt door middel van druk, fotoliople...met twos schouderbanden en is gemaakt van 6 Cordurn (Hp ]i.1A) . 0) doýý e henphand hey I nd t z iech tulltioW bhar d wnnrop melt schuifhiakezi de...tostonderdool word or eon significant vorschil. gevondon tussen hot pros tatiovorl ios (1) van do vrouweiijko on hot prostatie- verlios ( t ) van do

  14. Investigations of the relationship betw een disease and airborne (1→3)-β-D-glucan in buildings

    PubMed Central

    Rylander, Ragnar

    1997-01-01

    Studies on the relationship between symptoms in indoor air and the amount of airborne (1→3)-β-D-glucan were reviewed. Relationships were found for symptoms and objective tests of airways inflammation. The data suggest that (1→3)-β-D-glucan could be a causative agent. PMID:18472858

  15. Opbouw en Werking van een Multifunctie CO2-Laserradarsysteem (Construction and Function of a Multifunction CO2-Laser System)

    DTIC Science & Technology

    1991-09-01

    heterodyne detection technique- Examples of the results of range-, velocity- and vibration measurements with the laser syst eM shown and discussed. The lase...Korpel [2]) door ecm longitudinale akoestische golf in ecu kristarooster te beachouwen als ecu lopend tralie van dichtheidratiea. Ecu monochrome optiache...TNO mppon Natna 22 Als cen dubbele meting met twee bemonsterfrequenties resulteer mn twee gemeten afstandenR. en R2met dubbeiziniheidintervallen R

  16. Quick genome sequencing of “Candidatus Liberibacter” strains by use of Enrichment-Enlargement-Next generation sequencing (EEN)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Members of “Candidatus Liberibacter” are associated with several important plant diseases such as citrus Huanglongbing (HLB) and potato zebra chip (ZC) disease. Inability to culture and low titers in infected hosts have been major obstacles for research on these bacteria. The use of whole genome seq...

  17. Making Class Size Work in the Middle Grades

    ERIC Educational Resources Information Center

    Tienken, C. H.; Achilles, C. M.

    2006-01-01

    Most research on the positive effects of class-size reduction (CSR) has occurred in the elementary level (Word, Johnston, Bain, Fulton, Zaharias, Lintz, Achilles, Folger, & Breda, 1990; Molnar, Smith, Zahorik, Palmer, Halbach, & Ehrle, 1999). Is CSR an important variable in improving education in the middle grades? Can small classes be…

  18. The Juvenile Justice System. Chapter 6.

    ERIC Educational Resources Information Center

    1996

    This collection of papers presented at a 1996 conference on children's mental health focuses on the juvenile justice system. Papers have the following titles and authors: (1) "Delinquency and Mental Illness: The Intersection of Problems and Systems" (Carolyn S. Breda); (2) "Assessing the Mental Health of Adolescents in the Mental Health and…

  19. Directory of Adult Education Centres in Africa.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Dakar (Senegal). Regional Office for Education in Africa.

    The Bureau Regional pour L'Education en Afrique (BREDA) survey, published partly in French, assembled data on the activities of adult education institutions in Africa in order to identify and develop future regional documentation centers. This draft copy of the survey is the first step towards improving international collaboration among…

  20. Effects of hydrostatic pressure, agitation and CO2 stress on Phytophthora nicotianae zoospore survival

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Phytophthora nicotianae Breda de Haan was used as a model pathogen to investigate the effects of hydrostatic pressure, agitation, and aeration with CO2 or breathable air on the survival of Phytophthora zoospores in water. Injecting CO2 into 2 liters of zoospore-infested water for 5 min at 110.4 ml ...

  1. Quality of Expert Systems: Methods and Techniques (Kwaliteit van Expertsystemen: Methoden en Technieken)

    DTIC Science & Technology

    1989-12-01

    volledigheid van specificaties. De volledigheid is gewaarborgd door bet 100% principe. Het gebruik van een fornele taal voor vastlegging van de...impliceert statement coverage. c ) Condition coverage: ledere ’conditie’ (term in een Iogische expressie) moet bij bet testen tenminste een keer TRUE en...bijvoorbeeld een waarbij c I TRUE en c2 FALSE oplevert en een waarbij bet omgekeerde bet geval is. Merk op dat in dit geval niet aan decision coverage

  2. Architects of a brighter future.

    PubMed

    2008-10-01

    An imaginative scheme for a children's speech and language clinic to be sited in a part of Newcastle Upon Tyne rich in history, and a design for a new oncology centre, in Breda, Holland, conceived to help "break the taboo that shrouds cancer" won the student architects the first and second prizes respectively in the 2008 Architects for Health (AfH) Student Awards. Health Estate Journal reports.

  3. System Design and Wide-field Imaging Aspects of Synthesis Arrays with Phased Array Stations

    NASA Astrophysics Data System (ADS)

    Bregman, Jacob Dirk

    2012-12-01

    Dit proefschrift betreft het ontwerpen van synthese radiotelescopen, zoals LOFAR. Bekende ontwerpprincipes worden gecombineerd met een visie op technologische mogelijkheden die in de nabije toekomst binnen handbereik komen. De centrale vraag daarbij is hoe wetenschappelijke gebruikers met een gegeven budget een optimaal resultaat kunnen behalen. Systeemontwerp begint met een analyse van de fundamentele beperkingen van groothoek beeldvorming met apertuursynthese en van praktische beperkingen zoals verstoring door de ionosfeer. Deze analyse heeft geleid tot een aantal schaalwetten voor telescoop- en antenne-configuratie en voor de vereiste digitale processing. In een array antenne worden de signalen van een aantal antennes opgeteld tot een versterkt signaal uit een bepaalde richting. Deze array technologie geeft de mogelijkheid een gegeven aantal eenvoudige antennes optimaal te verdelen over een aantal stations. Ons onderzoek heeft laten zien dat de stations een minimum grootte nodig hebben om verstoring door de ionosfeer over het gehele beeldveld te kunnen corrigeren. Te kleine stations kunnen maar in een beperkt deel van hun grote beeldveld voldoende scherpte krijgen. Een te beperkt aantal stations leidt echter tot toename van ruis in het beeld die met extra beeldbewerking deels is te verwijderen. Een belangrijk resultaat van het werk is het ontwerp voor twee nieuwe methoden van beeldvorming waarbij de computer bewerking is teruggebracht tot een theoretisch minimum dat evenredig is met het oppervlak van het totale beeldveld gemeten in resolutie elementen. Voor een voldoend groot aantal stations is een optimale verdeling mogelijk waarmee maximale scherpte en minimale ruis is te realiseren binnen een totaal budget dat niet door de kosten van de benodigde computing faciliteiten wordt gedomineerd.

  4. A Real-Time Synthetic Aperture Radar Processor: Introduction and Project Description (Een Real-Time Synthetic Aperture Radar Processor: Introductie en Project Beschrijving)

    DTIC Science & Technology

    1991-11-01

    ontworpen toegespitst op de nieuwe algorithmen. Door gebruik te maken van par- aflelle structuren van algoritmen en van VLSI array processing, kunnen...report Page 4 ABSTRACT 2 SAMENVATTING 3 CONTENTS 4 LIST OF SYMBOLS 6 1 INTRODUCTION 7 1.1 VLSI array processing for SAR 7 1.2 SAR processing for VLSI array... MANAGEMENT 32 5.1 Time planning 32 5.2 Quality 32 5.3 Communication and information 33 5.4 Organization 35 6 RESEARCH 36 6.1 Research area 36 6.2

  5. Effects of Practice in Selecting and Executing Keypressing Sequences (Effecten van oefening op het selecteren en uitvoeren van een sequentiele toetsdruktaak).

    DTIC Science & Technology

    1992-10-07

    is concurrent with execution ( Klapp & Wyatt, 1976; Portier et al., 1990; Portier & Van Galen, in press; Rosenbaum et al., 1986). The second aspect is...1980). Use of simple reaction time in motor programming studies: A reply to Klapp , Wyatt, and Lingo. Journal of Motor Behavior 12, 163-168. Henry, EM...and analysis: A researcher’s handbook. Englewood Cliffs, NJ: Prentice-Hall. Klapp , S.T. & Wyatt, E.P. (1976). Motor programming within a sequence of

  6. The Physiological Basis for Thermal Comfort in Different Climates; a Preliminary Study (De fysiologische basis voor thermisch comfort onder diverse klimatologische omstandigheden; een voorstudie),

    DTIC Science & Technology

    2007-11-02

    Thermal comfort is very important for optimal functioning of humans. It gives information about the thermal state of the body, by which the human...receptors and sending efferent information to the effectors by which the body controls its temperature. Thermal comfort is determined by the temperature...global thermal comfort are core temperature, temperature of the extremities and temperature of the environment. In local thermal comfort and pain

  7. Dangerous Substance Advisor: Een Expert Systeem voor het Classificeren van Gevaarlijke Stoffen (Dangerous Substance Advisor: An Expert System for the Classification of Dangerous Substances)

    DTIC Science & Technology

    1990-06-01

    edition, New York, 1986. 5 Accord europ6en relatif au transport international des marchandises Dangereuses par i!oute (ADR) 1985. 6 UN ST/SG/AC.l10/1 3/Add...AFKORTINGEN ADR Accord europ6en relatif au transport international des marchandises Dangereuses par Route. ADNR Accord europ(en relatif au transport ...des marchandises Dangereuses par voie de navigation interieure Rhin. DOT Department Of Transport (USA). DSA Dangerous Substance Advisor. EEC European

  8. Civil and Military Satellite Communications: A Systems Overview and the Future Developments (Civiele en Militaire Satelliet-Communicatie: Een Overzicht van de Systemen en de te Verwachten Ontwikkelingen)

    DTIC Science & Technology

    1991-02-01

    IEEE Communications Magazine , September 1988 [6] S.J. Campanella... Communications Magazine , September 1988 [7] William T. Brandon, "Design trade-offs in antijam military satellite communications", IEEE Communications Magazine , July...34, IEEE Communications Magazine , May 1989 [9] Bert Wiggers and Marc van der Heyden, "Digital mobile telephone network threatened from

  9. Testing of a 1kW De Nora Solid Polymer Electrolyte Fuel Cell in Combination With a Lead Acid Battery (Het Testen van een 1 kW De Nora Vaste Polymeer Elektrolyt Brandstofcel in Combinatie Met een Loodzwavelzuuraccu; Eindrapport

    DTIC Science & Technology

    1998-09-01

    developments a commercial application in 5 to 10 years is feasible which means that the fuel cell can be used for the generation of electric energy on...is important. To get insight in the possible problems involved, TNO has carried out orientating tests with a fuel cell /battery combination. The...underlying report describes the results. The tests carried out are related to charging of the battery with the fuel cell (at various initial states of

  10. Geluidsexpositie bij gebruik van CEP door F-16 crewchiefs (Sound Exposure Level of F-16 Crew Chiefs Using Communications Earplugs)

    DTIC Science & Technology

    2008-03-01

    toepassehijke normen (en wettehjke voorschriften) wordt gedurende een werkdag, of gedurende een specifieke activiteit, het geluidniveau nabij bet hoofd...rechtstreeks kan worden vergeleken met tabelwaarden uit normen . In de handel verkrijgbare apparatuur (dosismeters) voeren de benodigde metingen en

  11. [In Process Citation].

    PubMed

    Brand, H S

    2014-12-01

    Wetenschappelijk onderzoek, zoals elke maand beschreven in het Nederlands Tijdschrift voor Tandheelkunde, begint met een idee. Om het idee te kunnen onderzoeken is vervolgens geld nodig. Hierbij gaat het meestal om grote bedragen. Zo kost een promotieonderzoek van 4 jaar een paar ton aan salariskosten en materialen.

  12. The Simulation of Cooling Flows in Clusters of Galaxies

    NASA Astrophysics Data System (ADS)

    Ahmed Mohamed Ismail, Nasser Mohamed

    2007-09-01

    Met behulp van computersimulaties bestudeerde Nasser Mohamed Ahmed de 'cooling flow' in sterrenstelsels. Tot nu werd aangenomen dat het om een constante stroom ging, maar Ahmed bewijst dat dit niet mogelijk is. In plaats daarvan introduceert hij een model voor een 'unsteady flow'.

  13. Energy and wear optimisation of train longitudinal dynamics and of traction and braking systems

    NASA Astrophysics Data System (ADS)

    Conti, R.; Galardi, E.; Meli, E.; Nocciolini, D.; Pugi, L.; Rindi, A.

    2015-05-01

    Traction and braking systems deeply affect longitudinal train dynamics, especially when an extensive blending phase among different pneumatic, electric and magnetic devices is required. The energy and wear optimisation of longitudinal vehicle dynamics has a crucial economic impact and involves several engineering problems such as wear of braking friction components, energy efficiency, thermal load on components, level of safety under degraded or adhesion conditions (often constrained by the current regulation in force on signalling or other safety-related subsystem). In fact, the application of energy storage systems can lead to an efficiency improvement of at least 10% while, as regards the wear reduction, the improvement due to distributed traction systems and to optimised traction devices can be quantified in about 50%. In this work, an innovative integrated procedure is proposed by the authors to optimise longitudinal train dynamics and traction and braking manoeuvres in terms of both energy and wear. The new approach has been applied to existing test cases and validated with experimental data provided by Breda and, for some components and their homologation process, the results of experimental activities derive from cooperation performed with relevant industrial partners such as Trenitalia and Italcertifer. In particular, simulation results are referred to the simulation tests performed on a high-speed train (Ansaldo Breda Emu V250) and on a tram (Ansaldo Breda Sirio Tram). The proposed approach is based on a modular simulation platform in which the sub-models corresponding to different subsystems can be easily customised, depending on the considered application, on the availability of technical data and on the homologation process of different components.

  14. Effect of Auditory Peripheral Displays On Unmanned Aerial Vehicle Operator Performance

    DTIC Science & Technology

    2008-06-01

    indicators of course&# 8208 ;deviations or late&# 8208 ;arrivals to targets for UAV missions with single and multiple UAVs. In particular, this thesis addresses...enhances a single operator?s performance in monitoring single and multiple, semi&# 8208 ;autonomous vehicles. The results also emphasize the necessity to...Veltman, & vanBreda, 1996; Flanagan,  McAnally, Martin, Meehan, & Oldfield, 1998; Nelson et al., 1998),  collision  avoidance  (Begault  &  Pittman

  15. A walk through the different spectral states of low-mass X-ray binaries

    NASA Astrophysics Data System (ADS)

    Hiemstra, Beike

    2012-02-01

    Lage-massa röntgendubbelstersystemen zijn systemen waarin een compact object, een neutronenster of een zwart gat, materie accreteert van een gewone ster die slechts een massa heeft kleiner dan of vergelijkbaar met die van onze zon. De materie-overdracht vindt plaats via een zogeheten accretieschijf waarin het materiaal naar het compacte object spiraliseert, en soms tot slechts een paar kilometer het compacte object nadert. Door interne wrijving wordt de accretieschijf zo heet dat het voornamelijk röntgenstraling uitzendt. Rondom de accretieschijf en het compacte object bevindt zich een heet plasma, de zogenoemde corona, dat röntgen- en gammastraling uitzendt. De geometrie en oorsprong van de corona zijn niet volledig bekend, maar waarnemingen en theoriën bevestigen de aanwezigheid ervan. Gebruik makend van röntgensatellieten bestuderen we de straling afkomstig van deze accretieschijf en corona welk bijdraagt aan het onderzoek aan compacte objecten en hun nabije omgeving. In dit proefschrift bestudeer ik specifieke eigenschappen van de accretieprocessen in röntgendubbelstersystemen. Deze processen manifesteren zich op verschillende manieren en zijn veranderlijk met tijd, leidend tot de verschillende zogeheten spectrale fases. De geometrie en de temperatuur van de accretieschijf en corona zijn karakteristiek in elk van deze fases. Dit proefschrift loopt door de verschillende spectrale fases heen waarbij vanuit een observationeel standpunt verscheidene bijzonderheden van elk van deze fases worden uitgelicht. Dit levert een belangrijke bijdrage aan de algemene kennis op het gebied van accretieprocessen in lage-massa röntgendubbelstersystemen.

  16. Europea Symposium. Education for Older Adults: A Mirror to Society = Europes Symposium. Educatie en Ouderen: Een Spiegelbeeld voor de Samenleving (Berg en Dal, The Netherlands, November 14-16, 1991).

    ERIC Educational Resources Information Center

    Klercq, Jumbo, Ed.; Damen, Ulrich, Ed.

    The following papers and workshop presentations are included in these proceedings: "Grandparents and Grandchild" (Goezinne-Zijlmans, Hirsch); "Call for an Open Discussion among the Professional Educators" (Klercq); "Energetic But Marginal--Paradox and Promise" (ter Steege); "Integration of Older People within the…

  17. Problemen zijn uitdagingen. Verslag van een studiereis naar de Verenigde Staten, van 21 april tot 7 mei 1995. (Problems Are Challenges. Report of a Study Tour in the United States, from April 21 to May 7, 1995).

    ERIC Educational Resources Information Center

    1995

    This document reports on a visit to the United States by individuals involved in Regional Education Centers (ROCs) in The Netherlands. The purpose of the visit was to study the phenomenon of community colleges as an example for ROCs in Holland. This document is the third in a series of reports that appear in connection with "The Transatlantic…

  18. The Influence of Protection, Mobility and Risk Perception on the Behaviour and Physical Performance of a Combat Soldier (De Invloed van Bescherming, Mobiliteit en Risicoperceptie op het Gedrag en de Fysieke Prestatie van een Gevechtssoldaat)

    DTIC Science & Technology

    2006-12-01

    which threat consisted of environmental stress (cold) and psychological pressure ( Liebermann et al., 2002). However, no reports were found in which...down on the ground during the last 40m, this could not explain the lower velocity in condition A. Liebermann et al. (2002) studied in exercises...vigilance were significantly impaired, as were more complex functions, including memory and logical reasoning. Liebermann et al. (2002) used environmental

  19. Scatterometry

    NASA Astrophysics Data System (ADS)

    Stoffelen, Adrianus Cornelis Maria

    1996-10-01

    Een veelheid aan meteorologische metingen is dagelijks beschikbaar. De meeste van deze waarnemingen bevinden zich echter boven land, en met name windwaarnemingen boven de (Noord Atlantische) oceaan zijn schaars. Bij een westelijke luchtstroming is dit een duidelijke beperking voor de weers- en golfverwachtingen ten behoeve van Nederland. Juist dan is het gevaar voor bijvoorbeeld storm of overstroming het grootst. Ook in het aardse klimaatsysteem speelt de wind aan het oppervlak een grote rol en is de belangrijkste factor voor de aandrijving van de oceaancirculatie. De oceaancirculatie op zijn beurt is cruciaal voor de verschijnselen die samenhangen met bijvoorbeeld El Niño. Dit proefschift gaat over het scatterometer instrument dat vanuit de ruimte, zelfs onder een wolkendek, nauwkeurige en betrouwbare informatie geeft over de wind aan het oceaanoppervlak met een hoge mate van ruimtelijke consistentie. Tijdens de tweede wereldoorlog werden radars aan boord van schepen veelvuldig gebruikt voor de opsporing van vijandige vaartuigen. Hierbij werd vastgesteld dat de detectie slechter werd naarmate de wind aan het zeeoppervlak groter was. Proefondervindelijk was hiermee het principe van een wind scatterometer aangetoond. Al snel ontwikkelde zich dan ook de idee de wind aan het zeeoppervlak te meten met behulp van radar. Vanuit een vliegtuig of een satelliet word dan een microgolfbundel onder een schuine hoek naar het zeeoppervlak gestuurd. De microgolfstraling, met gewoonlijk een golflengte van enkele centimeters, wordt verstrooid aan het ruwe oppervlak, en een klein gedeelte van de uitgezonden puls keert terug naar het detectorgedeelte van de scatterometer. Het fysische fenomeen van belang voor de werking van de scatterometer is de aanwezigheid van zogeheten capillaire gavitatiegolven op het zeeoppervlak. Deze golven hebben een golflengte van enkele centimeters en reageren vrijwel instantaan op de sterkte van de wind. De verstrooiing van microgolven is op zijn beurt

  20. Organic Semiconductors: A Molecular Picture of the Charge-Transport and Energy-Transport Processes.

    NASA Astrophysics Data System (ADS)

    Brédas, Jean-Luc

    2007-03-01

    Conjugated organic oligomer and polymer materials are being increasingly considered for their incorporation as the active semiconductor elements in devices such as photo-voltaic cells, light-emitting diodes, or field-effects transistors. In the operation of these devices, electron-transfer and energy-transfer processes play a key role, for instance in the form of charge transport (in the bulk or across interfaces), energy transport, charge separation, or charge recombination [1]. Here, we provide a theoretical description of electron-transfer phenomena based on electron-transfer theory, which allows us to provide a molecular, chemically-oriented understanding. In this presentation, we focus on the parameters that impact the mobility of charge carriers [2], that is the electronic coupling within chains and between adjacent chains and the reorganization energy of the chains upon ionization. Materials under study include conjugated oligomers such as oligoacenes, oligothiophene-acenes, oligothiophenes, and oligothienacenes. [1] J.L. Br'edas, D. Beljonne, V. Coropceanu, and J. Cornil, ``Charge-Transfer and Energy-Transfer Processes in pi-Conjugated Oligomers and Polymers'', Chemical Reviews, 104, 4971-5004 (2004). [2] V. Coropceanu, J. Cornil, D.A. da Silva Filho, Y. Olivier, R. Silbey, and J.L. Br'edas, ``Charge Transport in Organic Semiconductors'', Chemical Reviews, 107, xxx (2007).

  1. Computer Simulation of the Effect of Pretreatment with Reversible Acetylcholinesterase Inhibitors on the Protection Against Soman Poisoning

    DTIC Science & Technology

    1993-12-01

    dan 50 %/ acetyicholinesteraseremming, hetgeen in overeenstemming is met literatuurgegevens. Tevens voorspelt bet model dat het gebruik van een...soman- vergiftiging worden besproken. TNO-rcport PML 213493122 Page CONTENTS M.’ NAGEMENT-LTFFREKSEI. SUMNMARY/SAMENVATTING 3 CONTENTS 4 INTRODUCTION 6 2...genierkte i’-anties/personen ontvangen uitsluitend een management uittreksel, een documentatiepagina en de distributielijst van het rapport. 17* Lid van de

  2. Flitseenheid voor Ultra Snelle Fotografie (Flash Unit for High-Speed Photography)

    DTIC Science & Technology

    1992-09-01

    fotografie PML 1992-91 september 1992 Exemplaar no:- 10 Autmir(s): M. Koops T. Huijser Tow]aaiantal paginars: (oxcd. distr. Iijsl on RIDPj 50 Aantai...beschrijft de ontwikkeling van een hoog energetische gepulste lichthron ten behoeve an de ultra snelle fotografie . De gebouwde flitseenheid bestaat uit een... fotografie is een zeer geschikre diagnostische techrnek voor het vastleggen van snelle verschijnselen zoals die zich o.a. voordoen op het werkgebied

  3. Deterministic Combatmodels, Interim Report 1: Literature Research (Deterministische Gevechtsmodellen, Interim Rapport 1: Literatuur Onderzoek)

    DTIC Science & Technology

    1991-12-01

    This report contain-P a description of a study of the existing literature on deterministic zombai-models. The Lancheste quations are described, both...nadeel bieraan kleeft dat het uitvoeren van een studie met een dergelijk model redelijk veel tijd kost. Dit koint doordat er een groot aantal runs moet...oprijzen. De aannaznen die aan de kiassieke Lanchestervergehjkingen voor gericht vuur ten grondslag liggen zijn de volgende: " Elke partij is intern

  4. Inrichting Gemeenschappelijke Ops-Room Voor DTO, JCG en C2000 (A Common Operations Room for DTO, JCG and C2000)

    DTIC Science & Technology

    2007-02-01

    een 3D digitale eisen en wensen leiden tot nieuwe Beschrijving van de mockup en een 2D plattegrond van de uitgangspunten en tot herontwerp...initiele ontwerp is gemodelleerd in een 3D digitale mockup en 2D plattegrond van de ruimte. De unifornie werkplek, met gescheiden toegang tot secure en...geplaatst kunnen worden. Digitale 24-uurs klokken, minstens 5 of 6 tijdzones tegeijik. Er is 66n crisisruimate opgenomen in het ontwerp. Onduidelijk is

  5. Performance Measures: Search Performance for Different Fields-of Regard (prestatiemeting se: zoekprstatie bij geinstrumenteerd zien)

    DTIC Science & Technology

    2006-07-01

    FOV) grootte, resolutie, en opvallendheid van het doel. Proefpersonen moesten in een experiment zoeken naar doelen in geprojecteerde digitale foto’s. De...Zoekplaten De zoekplaten bestonden uit geprojecteerde digitale foto’s van landschappen en stadssc~nes met daarin een doel (zie figuur 2, 3 & 4). Dit...De resolutie Het beeldmateriaal werd opgenomen met een digitale camera van het type Sony DSC- P 12. De resolutie van de oorspron~ketijke beelden was

  6. Job Oriented Training: Handleiding Serious Gaming (Job Oriented Training: Handleiding (Handbook) Serious Gaming)

    DTIC Science & Technology

    2008-09-01

    vanafdag iin van een opleiding integrale taken uitvoeren in een omgeving die zoveel mogelijk lijkt op hun toekomstige beroepspraktijk. In dit geval...Korteling, dr A.H. van der Hulst, TNO Defensie en Veiligheid TNO Defensie en Veiligheid Program matitel Projecttitel Integrale opleidings- en PC Gaming...Oriented Training toegepast. Dit betekent in essentie dat de leerlingen vanaf dag een, integrale missies uitvoeren en niet eerst de theorie wordt

  7. EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering.

    PubMed

    Xiao, An; Wu, Yingdan; Yang, Zhipeng; Hu, Yingying; Wang, Weiye; Zhang, Yutian; Kong, Lei; Gao, Ge; Zhu, Zuoyan; Lin, Shuo; Zhang, Bo

    2013-01-01

    We report here the construction of engineered endonuclease database (EENdb) (http://eendb.zfgenetics.org/), a searchable database and knowledge base for customizable engineered endonucleases (EENs), including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). EENs are artificial nucleases designed to target and cleave specific DNA sequences. EENs have been shown to be a very useful genetic tool for targeted genome modification and have shown great potentials in the applications in basic research, clinical therapies and agricultural utilities, and they are specifically essential for reverse genetics research in species where no other gene targeting techniques are available. EENdb contains over 700 records of all the reported ZFNs and TALENs and related information, such as their target sequences, the peptide components [zinc finger protein-/transcription activator-like effector (TALE)-binding domains, FokI variants and linker peptide/framework], the efficiency and specificity of their activities. The database also lists EEN engineering tools and resources as well as information about forms and types of EENs, EEN screening and construction methods, detection methods for targeting efficiency and many other utilities. The aim of EENdb is to represent a central hub for EEN information and an integrated solution for EEN engineering. These studies may help to extract in-depth properties and common rules regarding ZFN or TALEN efficiency through comparison of the known ZFNs or TALENs.

  8. Algorithms for radio interference detection and removal

    NASA Astrophysics Data System (ADS)

    Offringa, Anne René

    2012-06-01

    Tijdens dit onderzoek hebben we gekeken naar de invloed van storing door menselijke apparatuur op radioastronomie. Radiosterrenwachten zoals Westerbork kunnen de hemel met een enorme gevoeligheid en resolutie in kaart brengen. Vaak bestaan zulke sterrenwachten uit een aantal grote schotelantennes. Echter, nieuwe technologische ontwikkelingen hebben ervoor gezorgd dat op lage frequenties vele kleine antennes efficiënt gecombineerd kunnen worden tot een grote schoteltelescoop. LOFAR is een nieuwe, deels-Nederlandse supertelescoop die gebruik maakt van dit principe. Deze telescoop bestaat uit tientallen velden gevuld met vele antennetjes, verspreid over Nederland en omringende landen. Het centrum van LOFAR bevindt zich in de buurt van het Drentse dorp Exloo. Radiotelescopen worden meestal in zeer afgelegen gebieden geplaatst, omdat menselijke apparatuur storing veroorzaakt. Het bouwen van een radiotelescoop op afgelegen locaties is echter niet goedkoop. LOFAR is een nieuwe weg ingeslagen en bevat antennevelden op diverse plaatsen in ons druk bevolkte land. Een belangrijke vraag was daardoor of de storing van menselijke apparatuur niet schadelijk zou zijn voor LOFAR-observaties. In dit proefschrift beantwoorden we deze vraag. We hebben volledig geautomatiseerde technieken ontworpen om storing te verwijderen. Met deze nieuwe technieken weten we de storing op zeer accurate wijze te scheiden van het hemelsignaal. We analyseren de gefilterde data en concluderen dat, na toepassing van deze technieken, we in staat zijn om zeer gevoelige hemelkaarten te maken met LOFAR. Daarmee lijkt het dus een goede keuze geweest te zijn om LOFAR in Nederland te bouwen.

  9. Methoden voor Voorraadbeheersing van Repareerbare Reservedelen: METRIC en Enkele Varianten (Methodes for Repairable Item Inventory Control: METRIC and Some Variants)

    DTIC Science & Technology

    1990-08-01

    geval van repareerbare items (voor niet-repareerbare items altijd 0), backorders - aantal exemplaren/ stuks van een item dat niet direct geleverd kan...worden (bet aantal stuks in nalevering). Hierbij geldt automatisch dat van de termen "on hand" en "backorders" minstens een van beide gelijk san nul is

  10. [Multidisciplinary treatment in orthodontics].

    PubMed

    Oosterkamp, B C M; Kuijpers, M A R

    2015-11-01

    In deze editie van het NTvT neemt het thema ‘Multidisciplinaire aanpak in de orthodontie’ de lezer mee in de mogelijkheden van multidisciplinaire zorg vanuit een orthodontisch oogpunt. Tandheelkunde is niet meer uitsluitend gericht op preventie en behandeling van cariës. De gebitstoestand van zowel ­kinderen als volwassenen is de afgelopen 30 jaar namelijk sterk verbeterd. De cariës­ervaring is duidelijk afgenomen en mensen behouden steeds langer hun natuurlijke gebit. Daarnaast is een fraai uitziend en goed functionerend gebit steeds vanzelfsprekender geworden en zijn patiënten gemotiveerd hun gebit te behouden. Deze ontwikkelingen vragen ook van (mond)zorgverleners een andere kijk op de zorg. De tandheelkundige zorg betreft steeds meer integrale zorg met een multidisciplinair karakter waarbij ­verschillende disciplines samenwerken om in samenspraak met de patiënt tot een optimaal resultaat te komen.

  11. Viruses and virus-like particles detected during examination of feces from calves and piglets with diarrhea

    PubMed Central

    Durham, Peter J.K.; Hassard, Lori E.; Norman, G.R. (Bob); Yemen, Roberta L.

    1989-01-01

    A total of 763 fecal or intestinal samples from diarrheic calves and piglets were examined for viral content by immunofluorescence, electron microscopy or cell culture. Routine fluorescent antibody and cultural tests detected rotavirus (n=126), coronavirus (n=80) and bovine viral diarrhea virus (n=13). Electron microscopy detected rotaviruses (n=24) and coronaviruses (n=17) not identified by standard fluorescent antibody tests. Other viruses detected by electron microscopy included Breda virus-like particles (n=49), astroviruses (n=1), caliciviruses (n=1), rhabdoviruses (n=1), parvoviruses (n=2), enteroviruses (n=3), togavirus-like particles (n=2), and “chained” particles (n=5). Mixtures of several of the viruses were detected in a number of fecal samples. The survey emphasized the value of electron microscopy as a broad-spectrum diagnostic tool. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8. PMID:17423455

  12. Infrared emission features: probing the interstellar PAH population and circumstellar environment of Herbig Ae/Be stars

    NASA Astrophysics Data System (ADS)

    Boersma, Christiaan

    2009-12-01

    AKs zijn alom vertegenwoordigd en bieden een uitstekend middel om de veelheid aan objecten verspreid over het heelal te bestuderen. Met name in gebieden waar zich sterren en planeten vormen, helpen ze bij het ontwarren van de grootschalige structuur. PAKs staat voor polycyclische aromatische koolwaterstoffen en ze vormen een familie van grote kippengaasvormige moleculen opgebouwd uit koolstof en waterstof. Op aarde worden ze onderander aangetroffen in de verbrandingsproducten van fossiele brandstoffen. PAKs vormen het overgangsgebied van stofdeeltjes ter grote van een micron naar moleculair "gas". PAKs zijn uniek op twee manieren. Allereerst, PAKs fluoresceren na de absorptie van een enkel ultraviolet foton, waardoor ze te zien zijn in zeer koude gebieden, ver weg van de aanstralende bron. In de tweede plaats, gegeven de complexiteit van deze moleculen, kunnen ze een belangrijke rol hebben gespeeld in het ontstaan van leven. Met behulp van topklasse ruimte- en grond gestationeerde observatoria, zoals bijvoorbeeld Spitzer en de 10-meter klasse telescopen in Chili, is de PAK-emissie afkomstig van middelzware, zich vormende, sterren onderzocht. Door gebruik van zowel beeldvorming als spectroscopie, zijn morfologische en evolutionaire aspecten van de PAK-emissie vastgesteld. De NASA Ames PAK IR Spectroscopische Database is een verzameling van meer dan 600 berekend en ongeveer 200 experimenteel bepaalde spectra. Deze unieke database gaat eind 2009 publiek. Gebruikmakend van deze database is een systematische zoektocht gedaan naar kandidaten die verantwoordelijk kunnen worden gehouden voor de emissie in twee, tot op heden, niet goed bestudeerde regio's van het PAKs-spectra.

  13. Het testen van een 1 kW De Nora vaste polymeer elekrolyt brandstofcel voor toepassing op oppervlakteschepen. Deel 2. Eindrapport fase 1 (Testing of a 1kW De Nora Solid Polymer Electrolyte Fuel Cell for Application on Board of Naval Surface Ships. Part 2. Final Report, Phase I).

    DTIC Science & Technology

    2007-11-02

    electrolyte fuel cell (PEFC) has good chances for this application also for application on board of ships. A 1 kW PEFC stack was purchased from the...Italian firm De Nora to obtain practical experience with this type of stack. Via a dedicated computer controlled fuel cell test system the fuel cell can...150 A) and 83% (0 A). The tested fuel cell meets the given vibration and shock requirements and shows no sign of damage at pressure differences up to 10 bars between the hydrogen and air compartment.

  14. High Performance Computing for Medical Image Interpretation

    DTIC Science & Technology

    1993-10-01

    Sepat voor inteanctieve visualisatie, quantizatierve analyse, (inverse) Taitcaipanning, neurochirurgie - planning en oldrtuigtijdens bet uitvoere van...quantitatieve analyse, (inverse) radiotherapieplanning, neurochirurgie - planning en ondersteuning tijdens bet uitvoeren van operaties. Gemntregeerd in een

  15. Treating Children and Adolescents

    MedlinePlus

    ... diet requires the exclusive use of special liquid formulas and the exclusion of all other forms of ... additional issue with EEN has been that the formulas used are largely unpalatable and require delivery through ...

  16. Assessment of Benefits and Drawbacks of Using Fuzzy Logic, Especially in Fire Control Systems

    DTIC Science & Technology

    1994-03-01

    classitied by :W. Pelt classitication date :September 20, 1993 jp:op:ved ci.’ :::: - - - - title :ongerubriceerd manage mentuittreksel :Ongerubriceerd...kanonsysteem het gebruik van "fuzzy reasoning" technieken voorkwam. Dit voorstel is gedaan door SIGNAAL, in een opdracht van de KM. Het TNO-FEL had een...van bet gebruik van fuzzy logic in vergelijking met ’conventionele’ methoden. Geconcludeerd wordt dat er in principe goede mogelijkhieden voor

  17. CTC Sentinel. Volume 3, Issue 3, March 2010

    DTIC Science & Technology

    2010-03-01

    NRC Handelsblad, September 19, 2005. 3 Ibid. 4 “De radicale da’wa: De opkomst van het neo-radical- isme in Nederland ,” Dutch Intelligence and...Security Ser- vice, 2007; “Weerstand en tegenkracht: Actuele trends en ontwikkelingen van het salafisme in Nederland ,” Dutch Intelligence and Security... Nederland . Aard, omvang en dreiging (Amsterdam: IMES, 2010). Another good overview is “Salafisme in Nederland : Een voorbi- jgaand fenomeen of een

  18. [In Process Citation].

    PubMed

    Vermaire, J H

    2014-10-01

    Bij het boeken van een vliegticket of treinkaartje komt de boeker van de reis onvermijdelijk voor de keuze tussen ‘first class’ of ‘economy’ te staan. Wat de uiteindelijke keuze wordt, is afhankelijk van verschillende factoren. Zo is het beschikbare aantal plaatsen belangrijk, maar zeker ook de preferenties van de reiziger (de waarde die men hecht aan beenruimte, een krant of iets te eten onderweg) en het beschikbare budget. Economie is de wetenschap die zich met deze vraagstukken bezighoudt.

  19. An Automated Air Sampling System Comprising an OPTIC GC Injector II, Quantification of VX Vapour

    DTIC Science & Technology

    2006-01-01

    hetsveeii t[lie contracting parties. S2006 INO 747n-7-6/- ()7V’ TNO I ensvorzknIN Een geautomatiseerd luchtmonstername- systeem met een OPTIC...de dampconcentratie. Het vorige rapport in deze serie beschreef de bepaling van soman-damp met dit systeem . Dit rapport beschrijft de bepaling van VX...van VX in de uitstromende lucht zal niet eenvoudig zijn. Beschrijving van de werkzaamheden Het OPTIC- systeem werd getest met het zenuwgas VX, dat qua

  20. Parallel Search for a Conjunction of Shape and Contrast Polarity

    DTIC Science & Technology

    1994-01-01

    F.L. Kooi 16 maart 1994, Rapport TM 1994 B-6 TNO Technische Menskunde’, Soesterberg MANAGEMENT UITTREKSEL Een object dat zich van andere objecten...polariteit Dr.ing. J. Thieeuwes en dr. F.L. Kooi 16 maart 1994, Rapport TM 1994 B-6 TNO Technische Menskunde’, Soesterberg MANAGEMENT UITTREKSEL Een object dat...visuele sYsteem niet in staat is parallel te zoeken onder twee stimulus dimensies tegelijkertijd. Eerder onderzoek heeft laten zien dat hierop twee

  1. GES User’s Guide Version 1.05

    DTIC Science & Technology

    2007-11-02

    energiesystemen aan elkaar gekoppeld worden. Daarvoor zijn een aantal afspraken gemaakt, hoe een specifiek systeem , in GES apparaat genoemd...zonder dat men direct rekening behoeft te houden met andere apparaten in het systeem . GES rekent stationaire Systemen door. Doordat er terugwerking...1997 2 Contents MANAGEMENTUITTREKSEL 1 1 INTRODUCTION 6 l.i PURPOSE OF GES 6 1.2 OVERVIEW OF GES 7 1.2.1 Energy apparatus 7 1.2.2 Signal

  2. Development and Construction of a Camera System for Landmine Detection

    DTIC Science & Technology

    2005-11-25

    Ontwikkeling en vervaardiging van een camera systeem voor Iandmijn detectie Eindrapport de ’haalbaarheidsfase’ is de haalbaarheid van verschillende...demonstratiesysteem gebouwd. Dit demonstratie- systeem bestaat uit een polarisatiecamera die speciaal voor dit doel is ontwikkeld en vervaardigd. Daamaast is software...ontwikkeld voor de automnatische detectie van Iandmidjnen en de visual-isatie van de detectieresultaten. Om de werking van het systeem te demonstreren

  3. Physical Protection: the State of the Art

    DTIC Science & Technology

    2005-02-01

    twee typen : keramische monolieten die zijn gecoat met een koolstof laagje en monolieten die volledig uit koolstof bestaan. Monolithische structuren...worden nieuwe typen actieve kolen ontwikkeld zoals kooldoek ’charcoal cloth’ en kooldraad ’charcoal fibre’, veelal gemaakt van polymeren. Tevens...8217, ontwikkeld in het kader van het ’Soldier Modernisation Program’, kan een manier zijn om de ergonomische, fysieke en psychologische belasting te verlagen. Op

  4. Toxicity Testing of Combustion Products of Polyurethane and Polyvinyichioride

    DTIC Science & Technology

    1999-01-01

    hand van bet vaststellen van de giftigheid van een tweetal veel gebruikte kunststoffen, polyurethaan (PUR) en polyvinyichioride ( PVC ). Ter TNO report...polyvinyichioride ( PVC ) speelt naast de vorming van CO ook zoutzuur (HC1) een belangrijke rol. Opvallend is dat de toxische effecten veel trager tot stand...kwamen dan bij de PUR-experimenten. Bij vermindering van het zuurstofgehalte tijdens de verbranding van PVC nam de toxiciteit niet toe. Op grond van

  5. Testbed Environment for Distributed Observation (testbed omgeving voor gedistribueerde waarneming)

    DTIC Science & Technology

    2006-05-01

    Een voorsiudie die tot de specificaties van het Testbed hebben geleid is heschreven in I Bovendien hevordert een Testhed omigeving, die in meerdere pro...functies loeaal functioneren (bijvoorbeeld pompen inschakelen, ruimtes afsluiten, et cetera) waardoor het systeem onafhankelijk wordt van eon centrale...ongebalanceerde koeling, et cetera) wordt met bebuip van actuatoren (kieppen, cross-overs, pompen , et cetera) bet systeemn gereconfiguroerd zodat de

  6. Generiek Materieellogistiek Ketenmodel Defensie (Generic Value Chain Model for Defense Material Organization)

    DTIC Science & Technology

    2008-04-01

    materidle gereedheid’ ofwel het realiseerbare aanbod, uitgedrukt in ’leverbaar aantal stuks materieelgereed materieel’. 2.3.1 De Materielogistieke waardeketen...8217beschikbaarheid’ terwijI in een C’ausal Loop Diagram dat is bedoeld voor latere MARVEL analyses, gesproken moet worden van ’aantal stuks materieel...materieelgereed materieel’ is. Athankelijk van de vraag van OPCO’s (gewenst aantal stuks materieelgereed materieeb) ontstaat er wel of miet een tekort aan materieel

  7. Inelastic processes in atomic collisions involving ground state and laser-prepared atoms

    NASA Astrophysics Data System (ADS)

    Planje, Willem Gilles

    1999-11-01

    In dit proefschrift worden experimenten beschreven waarbij ionen of atomen met een bepaalde snelheid op een ensemble van doelwitatomen worden gericht. Wanneer twee deeltjes elkaar voldoende genaderd hebben, vindt er wissel- werking plaats waarbij allerlei processen kunnen optreden. Deze processen resulteren in specieke eindproducten. Kennis over de interactie tussen twee botsingspartners wordt verkregen door te bekijken welke eindproducten ontstaan, en in welke mate. Een belangrijke grootheid die van invloed is op mogelijke processen is de onderlinge snelheid van de twee kernen, oftewel de botsingssnelheid. Wanneer de botsingssnelheid voldoende klein is dan kunnen de verschillende reactiemechanismen zowel kwalitatief als kwanti- tatief vaak goed voorspeld worden door het systeem te beschouwen als een kort-stondig molecuul, opgebouwd uit de twee botsende deeltjes. De ver- schillende processen die kunnen optreden worden gekwaliceerd afhankelijk van de vorming van bepaalde eindproducten. Ruwweg de volgende indeling kan gemaakt worden: 1. de interne structuur van de eindproducten zijn identiek aan die van de beginproducten. We spreken dan van een elastische botsing. 2. e en van de deeltjes of beiden worden in een aangeslagen toestand ge- bracht (of ge¨oniseerd). Dit zijn processen waarbij de herschikte elek- tronen zich bij de oorspronkelijke kern bevinden. We spreken dan van excitatie of ionisatie. 3. e en of meerdere elektronen bevinden zich bij de andere kern na de botsing (eventueel in aangeslagen toestand). We spreken dan van elek- tronenoverdracht. In het eerste deel van deze dissertatie worden botsingsexperimenten tussen heliumionen en natriumatomen beschreven waarbij het proces van elek- tronenoverdracht wordt onderzocht. Bij dit mechanisme is het buitenste 117?Samenvatting natriumelektron betrokken. Deze kan relatief gemakkelijk `overspringen' naar het heliumion wanneer deze zich dicht in de buurt van het natrium- atoom bevindt. Het elektron kan hierbij een

  8. Carbonate microfacies analysis of penecontemporaneous dolomites of the Carnian Travenanzes Formation (Southern Alps, Italy)

    NASA Astrophysics Data System (ADS)

    Niebergall, Simon Michael; Breda, Anna; Preto, Nereo; Habler, Gerlinde; Peckmann, Jörn; Meister, Patrick

    2016-04-01

    Abundant dolomite (MgCa(CO3)2) occurs in the Middle and Late Triassic carbonate record of the Tethys realm. Whereas dolomite formation is largely related to late diagenesis and/or hydrothermal activity, Preto et al. (2015) suggested a primary origin of dolomite beds and nodules intercalated in clay rich deposits of the Carnian Travenanzes Formation (Fm.; Dolomites, Venetian Alps) based on a transmission electron microscopy study. Thus, dolomites of the Travenanzes Fm. are supposed to have formed during or soon after deposition and its petrographic features may still be indicative of the geochemical conditions prevalent in the depositional setting. The Travenanzes Fm. records both carbonate and siliciclastic input, reflecting a transitional continental to shallow marine environment (Breda and Preto, 2011) with alternations of alluvial plains, sabkhas and/or ephemeral lakes. The goal of this study is to determine the microfacies of the dolomites of the Travenanzes Fm. and to discuss possible depositional environments and scenarios of penecontemporaneous dolomite formation. The samples were taken from the Dibona section described by Breda and Preto (2011). Optical microscopy documented three different types of dolomite: (1) Microcrystalline nodular dolomite shows abundant clay interlayers and fenestral pores filled with coelestine and barite. The homogenous microcrystalline dolomite was further investigated by electron backscatter diffraction (EBSD) mapping, revealing an anhedral to subhedral microstructure of grains ranging from 2 to 10 micrometers in diameter. Some dolomite grew as spherules within the clay matrix. (2) Dolomite pebbles show semi-rounded edges in a dolosparitic matrix. (3) Dolomite with mm- to cm-scale lamination shows regularly spaced undulation with the cuspate side directed upwards. The laminae are also commonly affected by brittle or plastic deformation. Based on the petrographic observations, the following conclusions can be drawn: (1) While the

  9. Early enteral nutrition in combination with parenteral nutrition in elderly patients after surgery due to gastrointestinal cancer

    PubMed Central

    Huang, Dongping; Sun, Zhufeng; Huang, Jianwei; Shen, Zhaozai

    2015-01-01

    Objective: To evaluate the therapeutic effects of nutritional support via different routes in elderly patients after surgery for gastrointestinal (GI) cancer. Methods: 105 patients with GI cancer were randomly divided into early enteral nutrition (EEN) group (n = 35), total parenteral nutrition (TPN) group (n = 35) and EN+PN group (n = 35). Results: The nutrition status and immunity were significantly compromised in all patients, while the liver function was improved at 3 days after surgery as compared to those before surgery. At 7 days after surgery, they returned to preoperative level. The nutrition status was comparable among 3 groups at 3 and 7 days after surgery (P > 0.05). ALT, AST, ALP and GGT in TNP group were significantly higher than those in EEN group and EN+PN group (P < 0.05), whereas there was no significant difference in the liver function between EEN group and EN+PN group (P > 0.05). The CD3+ cells, CD4+ cells and CD4/CD8 in EEN group and EN+PN group were significantly higher than those in TPN group (P < 0.05), but significant difference was not observed between EEN group and EN+PN group (P > 0.05). The NK cells in EN+PN group were significantly higher than in TPN group (P < 0.01). The incidence of diarrhea in EEN group was significantly higher than in TPN group and EN+PN group (P < 0.05). Conclusion: EN+PN is superior to EEN alone and TPN alone in the old patients with GI cancer in reducing the postoperative complications, improving the immunity and decreasing the hospital stay. PMID:26550350

  10. Toward enteral nutrition for the treatment of pediatric Crohn disease in Canada: a workshop to identify barriers and enablers.

    PubMed

    Van Limbergen, Johan; Haskett, Jennifer; Griffiths, Anne M; Critch, Jeff; Huynh, Hien; Ahmed, Najma; deBruyn, Jennifer C; Issenman, Robert; El-Matary, Wael; Walters, Thomas D; Kluthe, Cheryl; Roy, Marie-Eve; Sheppard, Elizabeth; Crandall, Wallace V; Cohen, Stan; Ruemmele, Frank M; Levine, Arie; Otley, Anthony R

    2015-10-01

    The treatment armamentarium in pediatric Crohn disease (CD) is very similar to adult-onset CD with the notable exception of the use of exclusive enteral nutrition (EEN [the administration of a liquid formula diet while excluding normal diet]), which is used more frequently by pediatric gastroenterologists to induce remission. In pediatric CD, EEN is now recommended by the pediatric committee of the European Crohn's and Colitis Organisation and the European Society for Paediatric Gastroenterology Hepatology and Nutrition as a first-choice agent to induce remission, with remission rates in pediatric studies consistently >75%. To chart and address enablers and barriers of use of EEN in Canada, a workshop was held in September 2014 in Toronto (Ontario), inviting pediatric gastroenterologists, nurses and dietitians from most Canadian pediatric IBD centres as well as international faculty from the United States and Europe with particular research and clinical expertise in the dietary management of pediatric CD. Workshop participants ranked the exclusivity of enteral nutrition; the health care resources; and cost implications as the top three barriers to its use. Conversely, key enablers mentioned included: standardization and sharing of protocols for use of enteral nutrition; ensuring sufficient dietetic resources; and reducing the cost of EEN to the family (including advocacy for reimbursement by provincial ministries of health and private insurance companies). Herein, the authors report on the discussions during this workshop and list strategies to enhance the use of EEN as a treatment option in the treatment of pediatric CD in Canada.

  11. Electron-Phonon Interactions in C_28-derived Molecular Solids

    NASA Astrophysics Data System (ADS)

    Romero, Nichols A.; Kim, Jeongnim; Martin, Richard M.

    2004-03-01

    We have investigated molecular solids made from various small close-shell fullerenes to determine their structural and electronic properties in their pristine and doped forms. Binding energies, band structure, and electron-phonon coupling were calculated using the ab initio SIESTA [1] code. We find a C_28H4 solid that binds weakly and exhibits many of the salient features of solid C_60. The electron-phonon interaction potential is over twice as large as that of C_60. Our calculations show that endohedral doping of the C_28H4 solid produces an electronic structure similar to that of the alkal-doped fullerides which is suggestive of high superconducting transition temperatures T_c. In keeping with simple estimates of Tc carried out in the literature (e.g. [2]), one obtains T_c( Na@ C_28 H_4)≈ 6T_c( K_3 C_60)≈ 116K. *Supported by NSF DMR 99-76550 and DOE DEFG-96-ER45439. [1] J. Soler et. al, J. Phys.: Condens. Matter 14, 2745 (2002). [2] N. Breda et. al, Phys. Rev. B 62, 130 (2000).

  12. Targeting individual excited states in DMRG.

    NASA Astrophysics Data System (ADS)

    Dorando, Jonathan; Hachmann, Johannes; Kin-Lic Chan, Garnet

    2007-03-01

    The low-lying excited states of π-conjugated molecules are important for the development of novel devices such as lasers, light-emitting diodes, photovoltaic cells, and field-effect transistors [1,2]. The ab-intio Density Matrix Renormalization Group (DMRG) provides a powerful way to explore the electronic structure of quasi-one-dimensional systems such as conjugated organic oligomers. However, DMRG is limited to targeting only low-lying excited states through state-averaged DMRG (SDMRG). There are several drawbacks; state-averaging degrades the accuracy of the excited states and is limited to at most a few of the low-lying states [3]. In this study, we present a new method for targeting higher individual excited states. Due to progress in the field of numerical analysis presented by Van Der Horst and others [4], we are able to target individual excited states of the Hamiltonian. This is accomplished by modifying the Jacobi-Davidson algorithm via a ``Harmonic Ritz'' procedure. We will present studies of oligoacenes and polyenes that compare the accuracy of SDMRG and Harmonic Davidson DMRG. [1] Burroughes, et al. , Nature 347, 539 (1990). [2] Shirota, J. Mater. Chem. 10, 1, (2000). [3] Ramasesha, Pati, Krishnamurthy, Shuai, Bredas, Phys. Rev. B. 54, 7598, (1997). [4] Bai, Demmel, Dongarra, Ruhe, Van Der Horst, Templates for the Solution of Algebraic Eigenvalue Problems, SIAM, 2000.

  13. Epigenetic Regulation of Hormone-dependent Plant Growth Processes

    SciTech Connect

    Ecker, Joseph Robert

    2016-11-18

    Impact of EIN6, EEN and ethylene on the H3K27me3 dynamics in Arabidopsis: To assess the dynamic responsiveness of H3K27me3 levels to ethylene and how this might affect ethylene-induced gene expression, we plan to perform H3K27me3 ChIP-seq and RNA- seq experiments in parallel with etiolated seedlings in the absence and presence of ethylene. Further implementation of ein6, een and ein6een mutants will visualize how the H3K27me3 landscape (-/+ET) is altered when H3K27me3 demethylation and/or INO80-mediated chromatin remodeling is compromised. Additional ChIP-seq analyses with EIN6 will show if ethylene- induced H3K27me3 removal at certain genes is always accompanied by the presence of EIN6.

  14. Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease.

    PubMed

    Cuív, Páraic Ó; Begun, Jakob; Keely, Simon; Lewindon, Peter J; Morrison, Mark

    2016-04-01

    Crohn's disease (CD) is a chronic disease characterized by episodic and disabling inflammation of the gastrointestinal tract in genetically susceptible individuals. The incidence and prevalence of CD is rising rapidly across the world emphasising that disease risk is also influenced by environmental and lifestyle factors, as well as the microbial community resident in the gut. Childhood-onset CD is associated with an aggressive disease course that can adversely impact patient growth and development. There is no cure for CD however new onset and recurrent cases of paediatric CD are often responsive to exclusive enteral nutrition (EEN) treatment. EEN treatment involves the exclusive consumption of an elemental or polymeric formula for several weeks and it is well established as a primary intervention strategy. EEN treatments typically achieve remission rates of over 80% and importantly they are associated with a high rate of mucosal healing, far superior to steroids, which is prognostic of improved long-term health outcomes. Furthermore, they are safe, have few side effects, and improve nutritional status and linear growth. Surprisingly, despite the utility of EEN our understanding of the host-microbe-diet interactions that underpin clinical remission and mucosal healing are limited. Here, we review the current state of knowledge and propose that the induction of autophagy, in addition to modulation of the microbiota and coordinated effects on inflammation and epithelial cell biology, may be critical for the therapeutic effects associated with EEN. A better understanding of EEN treatment will provide new opportunities to restore gut homeostasis and prolong periods of remission, as well as provide new insights into the factors that trigger and perhaps prevent CD.

  15. The Impact of Decreased Department of Defense Spending on Employment in the United States

    DTIC Science & Technology

    1991-11-01

    52..19....1. ............. 28 .0 .. 2880.4 Saut..e........:. De...en o . . De.ense, ...Rpr otePrsdn n h onrs Wsi . D ... C . .oe .mn.P.t. gOfie98 19...2eeneBde Pr c ... 1990).. -. The .Twagree comple-.tel -* t those. . een.n.abl.2.o.anauthors..... include nula ..eapon. ...n. the. Deatetohrfgrsfo...Ellis, James E. "Who Pays for Peace?" Business Week, 2 July 1990. 64-70. Fornell , Gordon E., and Glenn H. Vogel. "Forecasting the Economic Impact of

  16. Overview of Sortie-Numbers in Various Operations (Overzicht Sortie-Aantallen in Diverse Operaties)

    DTIC Science & Technology

    2005-03-01

    luchtcampagne tegen Joegoslaviý. Op 24 maart 1999 begon operatie ’Allied Force’. 2.7.2 Specifieke kenmerken operatie Operatie Allied Force vond plaats in...NAVO te fotograferen, maar ook omn de resultaten van de aanvallen vast te leggen. De KLu begon de operatie met een deelname van 16 F-1I6’s. Na ongeveer...dus 6 weken. De operatie Desert Storm begon met luchtaanvallen (16/17 januari 199 1). Op 23 feb ruari 1991 ontketendle een internationale troepenmacht

  17. Manufacturing Methods and Technology Engineering (MM and TE) Program for the Establishment of Production Techniques for High Density Thick Film Circuits used in Crystal Oscillators. Volume II.

    DTIC Science & Technology

    1980-04-01

    4- E--’ 4-’~-~I’ * - .L ___C LUJO - Ij LLL J c ~ ~C C’J U)U ZU 00 ) O Q C,, LL-I LU LU- F-i V7 LU -U EEnE E-J E .c ~ ~ ~ ( 0) (n EU, C ) E E I-J...trim, in process inspection. 11. Upon Q.C. acceptance, switch man/ auto switch to auto , and proceed with steps 2 through 9. While in auto , the procede

  18. Scientific climate change information by collaborative venture and digital portal

    NASA Astrophysics Data System (ADS)

    Dubelaar-Versluis, W.

    2010-09-01

    Klimaatportaal is the digital entry of Dutch ‘climate' knowledge centres, which are collaborated in the Platform Communication on Climate Change (PCCC). This collaborative venture was established in 2003 by the Dutch climate research community to improve the quality, efficiency and effectiveness of the communication of Dutch climate research. By now, eight Dutch knowledge centres are participating and still more want to join. The Ministry of Housing, Spatial Planning and the Environment (VROM) supports the PCCC and the project is implemented in collaboration with the BSIK ‘Climate Changes Spatial Planning' programme. The website provides actual and background climate change information for a wide audience on the national scale from policy makers, media to general public. By supplying integral climate information, such as observations of climate change, causes and consequences of climate system, adaptation, mitigation and energy issues, a wide spectrum of target groups will be served. The information is offered in different forms, because of the needs of different target groups. Klimaatportaal contains therefore news on climate issues, frequently asked questions and popular science reports, like the annually brochure De Staat van het Klimaat (‘The State of the Climate'). Recently, also a portal for students is added, where they can find information for their assignments. Beside the website, PCCC is organising activities as symposia and workshops and is supplying information on international issues, for example the content of the Kyoto protocol and the IPCC fourth assessment report (2007). Finally, informing the public through contacts with the media is also an important part of the PCCC. The presentation will address the strengths and weaknesses of this approach which may serve as an example for combining knowledge in outreach activities in other countries.

  19. Review of Published Safety Thresholds for Human Divers Exposed to Underwater Sound (Veilige maximale geluidsniveaus voor duikers - beoordeling van publicaties)

    DTIC Science & Technology

    2008-04-01

    niveaus zi.in primair bedoeld your gebruik direct als gevolg van het geluid of als onderzocht welke publicatie de meCest in relatie tot militaire sonars...bet gebruik van In een eerder uitgevoerd intern TNO underwater your duikers. De meest explosieven, heiwerkzaamheden en kennisinvesteringsproject is... Contents M anagem entuittreksel ........................................................................................... 2 SIntroduction

  20. Representation of Research Paradigms as a Function of Familiarity with Research Domains

    DTIC Science & Technology

    1992-07-01

    van de paradigma’s te kunnen vaststellen. Keuze van het Juiste paradigma werd bepaald door proefpersonen te vragen de betreffende zin te classificeren...als afkomstig van een bepaaid type onderzoek. De innoud van het paradigma werd bepaald door proefpersonen te, vragen zoveel kenmerken voor bet

  1. Kennislacunes op het gebied van wapens en munitie in OVG (Knowledge Gaps in the Area of Weapons and Munitions in MOUT)

    DTIC Science & Technology

    2008-12-01

    Militaire activiteiten Tabel 4 koppelt een overzicht van relevante militaire activiteiten in OVG aan operationele effecten volgens [2]. De koppeling ...Divert, Deter 6 Beheersen van menigten Degrade, Control 7 Uitwerkingsgebied " 8 Nevenschade - 9 Eigen veiligheid Met de koppeling van activiteiten en

  2. Interior Ballistics of Recoilless Guns

    DTIC Science & Technology

    1943-09-08

    PROCEDURE 14. Calculation of pressure -travel and velocity-travel curves ........................................... 17 PART IV. CHAPACTERISTICS OF...of a recoilless gun .............. 2 2. Comparison betw,:een pressure -travel curve calculated by the methods of this report and that obtained by...numerical integration ............................. 23 3. Theoretical pressure -travel and velocity-travel curves for the German 7.5-cm Leichtes Geschltz

  3. Exploring Muslim Diaspora Communities in Europe through a Social Movement Lens: Some Initial Thoughts

    DTIC Science & Technology

    2005-05-01

    phenomenon of diasporic collective contentious action, then, seems to make intuitive sense. Specifically, synthesizing SMT with emerging research on...een years, however, inquiry into diaspora communities has exploded, perhaps out of recognition that the concerns of diasporic networks have become...increasingly prominent in the unfolding of national and international politics[12] or simply out of recognition that diasporic terminology applies

  4. Effects of Aging and the Development of Automatic and Controlled Skills in Driving.

    DTIC Science & Technology

    1992-08-06

    performance may improve (e.g. Duncan, 1979, Korteling, 1991; Klapp , 1979, Peters, 1977). Klapp (1979), for example, pointed at superior time-sharing in...1979). Routeplanning en -geleiding: een literatuurstudie. Report IZF 1979 C-13, TNO Institute for Perception, Soesterberg, the Netherlands. Klapp , S.T

  5. Report on the Evaluation Results of the Course "Mechanic Undercarriage Leopard 2"

    DTIC Science & Technology

    2007-11-02

    Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Management uittreksel TNO Technische Menskunde, Soesterberg onderstel titel...bijvoorbeeld door Nederlandse bedrijven voor 3.5 miljard in opleidingen gei’nvesteerd (statistisch jaarboek CBS, 1996). Een belangrijke vraag bij...werkpiek (Billet, 1994). Alhoewel er weinig "harde cijfers" beschikbaar zijn over de mate van transfer van Nederlandse bedrijfsopleidingen, wijzen

  6. Operational Ocean Modelling with the Harvard Ocean Prediction System

    DTIC Science & Technology

    2008-11-01

    TNO Defence, Security and Safety Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek/ Netherlands Organisation for Applied...een goede blik in de wereld van de operationele oceanografie. Zonder in Nederland alle benodigde kennis en infrastructuur zelf op te bouwen, heeft...dit project handvatten geleverd voor verdere uitbouw van toepassing van operationele modellen binnen de Nederlandse krijgsmacht. Voor snelle

  7. Who Do We Deploy for Psychological Operations: A Function Profile for TPT Members

    DTIC Science & Technology

    2008-01-01

    Nederlandse Organisatie voor toegepast-natuurwetenschappeljk TNO efe sle n V ilig eldonderzoek / Netherlands Organisation for Applied Scientific...tactical PSYOPS teams (TPT) te selecteren. van psychologische operaties bij’rNO te komen tot een competentieprotiel voor de Nederlandse TPT-leden. Bovendien...interviews met en competentieprofielen. verhoudingen (sensitieve/intuftieve Nederlandse militairen werkzaarn op het Het competentiegedeelte van het functie

  8. Using the Euclid RTP11.13 Repository in the SEC Environment

    DTIC Science & Technology

    2006-03-01

    plaatsgevondert (verificatie) If Yes: author and report K3 Accreditation Heeft er toetsing aan normen plaatsgevonden N (accreditatie) If Yes: author and...specificaties plaatsgevonden (verificatie) K2 K3 Heeft er toetsing aan normen plaatsgevonden (accreditatie) K3 K4 Heeft er een subjectieve validatie van de

  9. Early enteral nutrition vs parenteral nutrition following pancreaticoduodenectomy: Experience from a single center

    PubMed Central

    Lu, Jian-Wen; Liu, Chang; Du, Zhao-Qing; Liu, Xue-Min; Lv, Yi; Zhang, Xu-Feng

    2016-01-01

    AIM: To analyze and compare postoperative morbidity between patients receiving total parenteral nutrition (TPN) and early enteral nutrition supplemented with parenteral nutrition (EEN + PN). METHODS: Three hundred and forty patients receiving pancreaticoduodenectomy (PD) from 2009 to 2013 at our center were enrolled retrospectively. Patients were divided into two groups depending on postoperative nutrition support scheme: an EEN + PN group (n = 87) and a TPN group (n = 253). Demographic characteristics, comorbidities, preoperative biochemical parameters, pathological diagnosis, intraoperative information, and postoperative complications of the two groups were analyzed. RESULTS: The two groups did not differ in demographic characteristics, preoperative comorbidities, preoperative biochemical parameters or pathological findings (P > 0.05 for all). However, patients with EEN + PN following PD had a higher incidence of delayed gastric emptying (16.1% vs 6.7%, P = 0.016), pulmonary infection (10.3% vs 3.6%, P = 0.024), and probably intraperitoneal infection (18.4% vs 10.3%, P = 0.059), which might account for their longer nasogastric tube retention time (9 d vs 5 d, P = 0.006), postoperative hospital stay (25 d vs 20 d, P = 0.055) and higher hospitalization expenses (USD10397 vs USD8663.9, P = 0.008), compared to those with TPN. CONCLUSION: Our study suggests that TPN might be safe and sufficient for patient recovery after PD. Postoperative EEN should only be performed scrupulously and selectively. PMID:27076767

  10. Geluidsexpositie bij Gebruik van Otoplastieken met Communicatie (Sound Exposure Level of F-16 Crew Chiefs Using Custom Molded Communications Earplugs)

    DTIC Science & Technology

    2008-10-01

    Distributielijst Onderstaande instanties/personen ontvangen een volledig exemplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie... digitale versie bijgeleverd op cd-rom) 5/7 Bibliotheek KMA 8/9 TNO Defensie en Veiligheid, vestiging Soesterberg, (Archief) 10/11 TNO Defensie

  11. Commentaar.

    PubMed

    Noorlander, E

    1999-12-01

    Het mag als een verworvenheid beschouwd worden dat er sinds kort stoffen op de markt zijn die de kans op terugval van alcoholisten verkleinen. Natuurlijk hebben deze stoffen, zoals acamprosaat en naltrexon indicaties en contra-indicaties, en die zijn in de voorgaande artikelen beschreven. Het is daarmee echter nog niet gemakkelijk geworden een richtlijn voor de dagelijkse praktijk te formuleren. Dat blijkt wel uit deze artikelen. Immers, acamprosaat is effectief gebleken, maar nu ook weer niet zó effectief dat het niet voorschrijven ervan per definitie een gemiste kans moet worden beschouwd. De Jong en Schippers wijzen er terecht op dat als stoffen té enthousiast worden voorgeschreven, zoals dat met disulfiram is gebeurd, het grote aantal mislukkingen ertoe kan leiden dat men zich weer teleurgesteld van zo'n stof afwendt. En het risico op dit soort therapeutisch enthousiasme is juist bij de behandeling van verslavingen levensgroot. Er zijn weinig ziektebeelden die bij een behandelaar zoveel machteloosheid kunnen oproepen en dus zoveel neiging naar strohalmen te grijpen.

  12. Development of Elastomeric Polypeptide BIomaterials.

    DTIC Science & Technology

    1998-01-01

    set of experimental observations on. a family of elastomeric protein-based polymers , five axiomsTiaye^een deyefoped whiCh , ( govern protein...demonstrated to be competition for hydration between hydrophobic and polar moieties These developments represent the nuts and bolts of amphiphilic polymer ...structure formation, function and engineering by means of hydrophobic folding and assembly. Basically, amphiphilic polymers , including proteins and

  13. Electronic Engineering Notebook: A software environment for research execution, documentation and dissemination

    NASA Technical Reports Server (NTRS)

    Moerder, Dan

    1994-01-01

    The electronic engineering notebook (EEN) consists of a free form research notebook, implemented in a commercial package for distributed hypermedia, which includes utilities for graphics capture, formatting and display of LaTex constructs, and interfaces to the host operating system. The latter capability consists of an information computer-aided software engineering (CASE) tool and a means to associate executable scripts with source objects. The EEN runs on Sun and HP workstations. The EEN, in day-to-day use can be used in much the same manner as the sort of research notes most researchers keep during development of projects. Graphics can be pasted in, equations can be entered via LaTex, etc. In addition, the fact that the EEN is hypermedia permits easy management of 'context', e.g., derivations and data can contain easily formed links to other supporting derivations and data. The CASE tool also permits development and maintenance of source code directly in the notebook, with access to its derivations and data.

  14. Multi-Band Frequency Selective Surfaces: Analysis

    DTIC Science & Technology

    2008-08-01

    antennas using EBG substrates", Ph.D. dissertation, Departamento de Comunicaciones , Universidad Politecnica de Valencia, Valencia, Spain, 2006. [21...Distribution list Onderstaande instanties/personen ontvangen een volledig exemplaar van bet rapport. I DMO/SC-DR&D standaard inclusief digitale versie

  15. Secure Open Systems an Investigation of Current Standardisation Efforts for Security in Open Systems

    DTIC Science & Technology

    1992-06-01

    systeem (hardware, netwerk, besturingssysteem, applicadcs) in onderlinge afstemming en sarnenhang de noodzakelijke beveiliging moewen bieden. Allcreerst...elementen van cen open systeem . SGeen van de initiatieven biedt functionaliteit voor het representeren van nonnale organisatie. structuren, taken en...verantwoordebjkhcden in een systeem . 4 Geen van de initiatieven biedt aandacht aan de beveiligingseisen die voortkomen ult maatschappelijke relaties. 5

  16. Werkbelasting Is Nog Geen Stress (Workload Does Not Necessarily Produce Stress)

    DTIC Science & Technology

    1991-09-10

    van de primaire taak. Op grand van de mate van interferentie voor verschillende typen tweede taken kunnen uitspraken gedaan warden over de componenten...mensen lopen een ver- hoogd gezondheidsrisico, omdat eerder cumulatieve effecten ontstaan, die leiden tot psychologische en psychosomatische klachten...van psychologische aard zijn. Vaak realiseert men zich niet dat aan mentale inspanning (aandacbt, concentratie, inzet) fysiologische kosten verbonden

  17. Speaking Rate from Proximal and Distal Contexts Is Used during Word Segmentation

    ERIC Educational Resources Information Center

    Reinisch, Eva; Jesse, Alexandra; McQueen, James M.

    2011-01-01

    A series of eye-tracking and categorization experiments investigated the use of speaking-rate information in the segmentation of Dutch ambiguous-word sequences. Juncture phonemes with ambiguous durations (e.g., [s] in "eens (s)peer," "once (s)pear," [t] in "nooit (t)rap," "never staircase/quick") were…

  18. Velocity Measurements on the Electric Gun Developed at the TNO Prins Maurits Laboratory (Snelheidheidsmetingen aan de bij het Prins Maurits Laboratorium Ontwikkelde Electric Gun)

    DTIC Science & Technology

    1993-03-01

    8217te veel’ aluminium explodeert. Dit wordt weergegeven door het gearceer.1e gebied. Doordat er een stuk aluminiumn over het koper uitsteekt explodeert...worden de beperkingen van de verschillende meetmethoden toegelicht. De grootste fout komt uit de snelheidsmeting. Het aantal fibers (6 stuks ), de

  19. Effect of early enteral nutrition on patients with digestive tract surgery: A meta-analysis of randomized controlled trials

    PubMed Central

    Shu, Xiao-Liang; Kang, Kai; Gu, Li-Juan; Zhang, Yong-Sheng

    2016-01-01

    Postoperative early enteral nutrition (EEN) is useful for the effective recovery of patients that have undergone surgery. However, the feasibility and efficacy of EEN in patients with digestive tract surgery remain inconclusive. In the present meta-analysis, the PubMed, EMBASE, Web of Science, The Cochrane Library, China National Knowledge Infrastructure and VIP databases were searched to identify controlled trials of patients with and without EEN following digestive tract surgery between October, 1966 and December, 2014. Methodological quality assessment was carried out for each of the included studies. For estimation of the analysis indexes, relative risk (RR) was used as the effect size of the the categorical variable, while the weighted mean difference (MD) was used as the effect size of the continuous variable. The meta-analysis was conducted using RevMan 5.2 software. Eleven randomized controlled trials involving 1,095 patients were included in the meta-analysis. The results revealed that, EEN in patients with digestive tract surgery was more effective in decreasing the incidence of infectious [RR=0.50, 95% confidence interval (CI): 0.38, 0.67; P<0.01] and non-infectious complications (RR=0.72, 95% CI: 0.43, 1.22; P<0.05) and shortening the length of first bowel action (MD=−4.10, 95% CI: −5.38, −2.82; P<0.05). It also had a significant influence on increasing the serum albumin (MD=2.87, 95% CI: 1.03, 4.71; P<0.05) and serum prealbumin (MD=0.04, 95% CI: 0.02, 0.05; P<0.05) levels. In conclusion, the results of the study have shown that EEN in patients with digestive tract surgery improved the nutritional status, reduced the risk of postoperative complications, shortened the length of hospital stay and promoted the functional recovery of the digestive system. PMID:27698702

  20. Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.

    PubMed

    Ng, Ray Kit; Kong, Cheuk Ting; So, Chi Chiu; Lui, Wing Chi; Chan, Yuen Fan; Leung, Ka Chun; So, Kam Chung; Tsang, Ho Man; Chan, Li Chong; Sham, Mai Har

    2014-01-01

    HOX genes are frequently dysregulated in human leukaemia with the gene rearrangement between mixed lineage leukaemia (MLL) and partner genes. The resultant MLL fusion proteins are known to mediate leukaemia through disruption of the normal epigenetic regulation at the target gene loci. To elucidate the pathogenic role of MLL fusion proteins in HOX dysregulation in leukaemia, we generated a novel haematopoietic lineage-specific Mll-Een knock-in mouse model using a Cre-mediated inversion strategy. The Mll(Een) (/+) invertor mice developed acute myeloid leukaemia, with organomegaly of the spleen, liver and mesenteric lymph nodes caused by infiltration of blast cells. Using Mll-Een-expressing leukaemic cell lines derived from bone marrow of Mll(Een) (/+) mutant mice, we showed that induction of Hox genes in leukaemic cells was associated with hypomethylated promoter regions and an aberrant active chromatin state at the Hox loci. Knock-down of Prmt1 was insufficient to reverse the active chromatin status and the hypomethylated Hox loci, suggesting that Prmt1-mediated histone arginine methylation was only partially involved in the maintenance of Hox expression in leukaemic cells. Furthermore, in vivo analysis of bone marrow cells of Mll(Een) (/+) mice revealed a Hox expression profile similar to that of wild-type haematopoietic stem cells. The leukaemic Hox profile was highly correlated with aberrant hypomethylation of Hox promoters in the mutant mice, which highlights the importance of DNA methylation in leukaemogenic mechanisms induced by MLL fusion proteins. Our results point to the involvement of dynamic epigenetic regulations in the maintenance of the stem cell-like HOX code that initiates leukaemic stem cells in MLL-rearranged leukaemia. This provides insights for the development of alternative strategies for leukaemia treatment.

  1. QTLs for straw quality characteristics identified in recombinant inbred lines of a Hordeum vulgare x H. spontaneum cross in a Mediterranean environment.

    PubMed

    Grando, S; Baum, M; Ceccarelli, S; Goodchild, A; El-Haramein, F Jaby; Jahoor, A; Backes, G

    2005-02-01

    Barley straw is commonly used as animal feed in many developing countries. Even a small increase in its nutritive value can have a large impact on animal production, and hence, on rural livelihood and human nutrition. Straw quality is strongly affected by environmental factors and is, therefore, difficult to improve with empirical breeding. The objective of this study was to identify molecular markers to facilitate the improvement of straw quality in barley. For this purpose, we have used the genetic linkage map that was already developed for recombinant inbred lines (RILs) of the cross between a Hordeum vulgare cultivar ('Arta') and a H. spontaneum line (H. spontaneum 41-1), covering a total of 890 cM. Straw parameters from RILs grown at Tel Hadya and Breda (ICARDA's research stations) in 2 years (1996/1997 and 1997/1998) were analyzed by NIRS for predicted nutritional characteristics including neutral detergent fiber, acid detergent fiber, lignin, digestible organic matter in dry matter, voluntary intake, crude protein, and straw morphology (the percentage of blades, sheaths, and stems). Localization of QTLs was performed using Windows QTL Cartographer, version 2.0. Seventy-three QTLs were identified, the majority of which (17) in the driest of the four environments. Only six QTLs were identified in two environments; in five cases, one of the two was the wettest environment. This is discussed in relation to the possibility of improving straw quality in favorable environments where yields are higher, rather than in dry environments where straw quality is already relatively good.

  2. Dementia and delirium, the outcomes in elderly hip fracture patients

    PubMed Central

    Mosk, Christina A; Mus, Marnix; Vroemen, Jos PAM; van der Ploeg, Tjeerd; Vos, Dagmar I; Elmans, Leon HGJ; van der Laan, Lijckle

    2017-01-01

    Background Delirium in hip fractured patients is a frequent complication. Dementia is an important risk factor for delirium and is common in frail elderly. This study aimed to extend the previous knowledge on risk factors for delirium and the consequences. Special attention was given to patients with dementia and delirium. Methods This is a retrospective cohort study performed in the Amphia Hospital, Breda, the Netherlands. A full electronic patient file system (Hyperspace Version IU4: Epic, Inc., Verona, WI, USA) was used to assess data between January 2014 and September 2015. All patients presented were aged ≥70 years with a hip fracture, who underwent surgery with osteosynthesis or arthroplasty. Patients were excluded in case of a pathological or a periprosthetic hip fracture, multiple traumatic injuries, and high-energy trauma. Patient and surgical characteristics were documented. Postoperative outcomes were noted. Delirium was screened using Delirium Observation Screening Scale and dementia was assessed from medical notes. Results Of a total of 566 included patients, 75% were females. The median age was 84 years (interquartile range: 9). Delirium was observed in 35%. Significant risk factors for delirium were a high American Society of Anesthesiology score, delirium in medical history, functional dependency, preoperative institutionalization, low hemoglobin level, and high amount of blood transfusion. Delirium was correlated with a longer hospital stay (P=0.001), increased association with complications (P<0.001), institutionalization (P<0.001), and 6-month mortality (P<0.001). Patients with dementia (N=168) had a higher delirium rate (57.7%, P<0.001) but a shorter hospital stay (P<0.001). There was no significant difference in the 6-month mortality between delirious patients with (34.0%) and without dementia (26.3%). Conclusion Elderly patients with a hip fracture are vulnerable for delirium, especially when the patient has dementia. Patients who underwent

  3. Theoretical study of geometrical and electronic structures of various thiophene-based tricyclic polymers

    NASA Astrophysics Data System (ADS)

    Hong, Sung Y.; Song, Jung M.

    1997-12-01

    A theoretical study of a variety of tricyclic polymers [-(C8H2X2Y)n-] with two different types of bridging groups was performed, X=S and Y=CH2, SiH2, C=O, C=S, or C=CH2 for the fused bithiophene system and vice versa for the thieno-bicyclic system. These two types of the bridging groups are different from each other in that S favors the aromatic form of a cyclic polymer and the other groups prefer the quinonoid form. Geometrical structures of the polymers were obtained from semiempirical self-consistent-field (SCF) band calculations and the electronic properties from the modified extended Hückel band calculations. It is found that the ground-state geometrical structures of the tricyclic polymers are determined by the bridging groups in the outer rings. That is, the fused bithiophene system is aromatic in the ground state and the thieno-bicyclic system is quinonoid. The ground-state band gaps (which correspond to the absorption peaks of π-π* band transition) of the polymers were estimated to be in the range of 0.7-2.0 eV. The band gaps were analyzed in terms of the bond-length alternation along the conjugated carbon backbone, the C1-C4 interactions, and the electronic effect of the bridging groups. We also investigated the geometrical and electronic structures of polydicyanomethylene-cyclopenta-dicyclopentadiene (PDICNCY). Unlike the theoretical predictions of Toussaint and Bredas [Synth. Met. 69, 637 (1995)], PDICNCY in the ground state was estimated to be of the quinonoid form and to possess a large band gap (2.55 eV) comparable with the gap of polythiophene.

  4. Cooper River Rediversion Project. Lake Moultrie and Santee River, South Carolina. Intake and Tailrace Canals.

    DTIC Science & Technology

    1976-06-01

    approximately 40 miles southeast of the project in an area bet.,een the Edisto and Ashley Rivers . Due to the limitations of the investigations, they... River basin . A larger ditch would collect runoff for the remainder of the intake canal beginning at approxi- mate canal station 233+00 draining...between the Edisto and Ashley Rivers . Due to the limitations of the in- vestigations, they were not able to delineate a strike trend for the fault. No

  5. International Aerospace and Ground Conference on Lightning and Static Electricity (8th): Lightning Technology Roundup, held at Fort Worth, Texas on 21-23 June 1983.

    DTIC Science & Technology

    1983-06-01

    of the large eddy in the course of the day NEW MEiANISM (Fig.5). This is seen as the rising inversion of the day time planetary A new mechadism for...continuous spectrum of Brunt Valsalansm as oxpl6suod be low, eddies in the atmosphere can be ,een from The atmospheric planetary boundary the...microecalo-capping-inversion layers in Schmidt-Bauer currents. The aerosol the atmospheric planetary boundary layer current (IA) proposed in the

  6. WitnessMan: The Software Tool to Design, Analyse and Assess a Witness Pack with Respect to Military and Medical Effects on an (un)Protected (dis)Mounted Soldier

    DTIC Science & Technology

    2006-03-01

    platen, waarde , de kosten en doorlooptijd van het seerd op een database met ComputerMan- worden geruime tijd na afloop van het expe- onderzoek...value of experimental research. WitnessMan modular software structure enables future improvements and TNO report I TNO-DV2 2006 A014 5 / 21 Contents M...Hoeneveld, DMO-Munitiebedrijf 5/7 Bibliotheek KMA 8 TNO Defensie en Veiligheid, vestiging Rijswijk Manager Besclierming, Munitie en Wapens (operaties

  7. Cognitive Ability and Whole-Body Rotation (Cognitief Vermogen en Rotatie van het Lichaam)

    DTIC Science & Technology

    1993-03-01

    unlimited. •If ". ,hA 2 CONTENTS Page SUMMARY 3 SAMENVATnING 4 1 GENERAL PROBLEM AREA 5 2 TASKS AND MOVEMENTS 5 3 PREVIOUS RESULTS FOR ACTIVE BODY...suggeree~n r. Het huidige experiment maakte gebruik van de gemotori- seerde draaistoel van bet IZF. Terwiji gedraaid werd voerden de proefpersonen een...processing, irrespective of content of cognitive processing (spatial or verbal- numerical). The interaction between body rotations and cognitive content

  8. Models and Building Blocks for Secure Open Systems

    DTIC Science & Technology

    1992-11-01

    benadcringcn met elkaar vergeleken en wordt. zo mogelijk, een gemcenschappciijke basis voor de verschillende mogelijkheden gezocht met gebruik van...volgens de in deze studie beschreven modellen voor beveiliging in open systemen. TNO report Page 5 CONTENTS ABSTRACT 2 SAMENVATrING 3 CONTENTS 5...special problem since each element in an open system (hardware, networks, operating systems, database management systems and other applications) must be

  9. Buffer Loading and Chunking in Sequential Keypressing (Het Laden van de Motor Buffer Versus Het Gebruik van Motor Chunks bij Sequentieule Toetsdrukseries)

    DTIC Science & Technology

    1994-03-18

    chunking in sequential keypressing (Het laden van de motor buffer versus het gebruik van motor chunks bij sequentiele toetsdrukseries) W.B. Verwey 18 maart...1994, Rapport TM 1994 B-7 TNO Technische Menskunde’, Soesterberg MANAGEMENT UITTREKSEL Dit rapport beschrijft een experiment naar de effecten van...Menakunde. Korte samenvatting van: Buffer loading and chunking in sequential keypressing (Het laden van de motor buffer versus het gebruik van motor

  10. JPRS Report, China.

    DTIC Science & Technology

    2007-11-02

    Zhu Rongji [Hong Kong TANG TAI No 3] .......................................... 1 D ifference Betw een Zou, Zhu...caution; otherwise, it will be extremely Difference Between Zou, Zhu easy for the party to come to a premature end. From a look 91CM0504A Hong Kong TANG ...is very Representatives of Two Forces difficult for him to truly win the trust of the Chinese 91CM0504B Hong Kong TANG TAI Communist elders. When Zhu

  11. Multimodal Imaging of Pathophysiological Changes and Their Role in Development of Breast Cancer Brain Metastasis

    DTIC Science & Technology

    2010-09-01

    time when systemic disease is under good control. In part, this may be du e to the fact that chemotherapeutic agents that show efficacy against...systemic disease , may have p oor penetration of the blood-brain barrier (BBB), which means that breast cancer metastasis in the brain may remain untreated...located betw een parenchyma and leptomeninges Metastatic lesions at brain parenchyma sho wed significan tly more perfusion, as compared to those l

  12. Investigation of Fire-Vulnerability-Reduction Effectiveness of Fire-Resistant Diesel Fuel in Armored Vehicular Fuel Tanks

    DTIC Science & Technology

    1980-09-30

    Page 1 Six Generations of Fire-Resistant Fuel Formulations Investigated by the U.S. Army.................................. 2 Referee-Grade-Base-Fuel...A. Background Information Six generations of fire-resistant fuel have ,een investigated by the Army, and these are summarized in Table 1. (2,3) The...8217. . ’ , I TABLE I. SIX GENERATIONS OF FIRE-RESISTANT FUEL FORMULATIONS INVESTIGATED BY THE U.S. ARMY 1. Fuel gellation just prior to hazard

  13. Memory-Based Expert Systems

    DTIC Science & Technology

    1987-06-01

    a consequence J-. MTRANSEVENT f Awl (he)moblct IFORMTIO MTRANS-EVNSETN oft mi (ecoomisECO : CAUSA acormblect ECO :EVENT ECO :EVENT MS IR: AUSAL LESTER...OHN-D E M EO EVEN ECO :EVENT {econom ECO : CAUSA . ON IST n 2I MF:MTR, NS-EVENT : atrmbet ECO :EVENT ECO :EEN " < :MSAR:AUSAL- ." LESTER-THUROW MILTON

  14. Airbase Operations Wargame (User Manual). Version 2.0

    DTIC Science & Technology

    1994-01-01

    geven van opdrachten. Er zijn 2 versies van bet model beschikbaar: - Versie 1, AQW-I, bet stand alone ofwel single user systeem - Versie, 2, AOW-II...spelershandleiding als een handleiding voor de spelleiding bescbikbaar waafri bet gebruik van bet model (zowel AOW-I als AQW-II) wordt toegelicbt...AOW system is a model of the real world communications between the airbase commander and his staff and a real airbase. Fig. 2. 1: Simulated organization

  15. Radiological Defense. Volume 4. An Introduction to Radiological Instruments for Military Use

    DTIC Science & Technology

    1950-01-01

    atomnic lbomnl explosion , increuis- applies to the (lefense establishment, has been emphalmsis and thoughlt have b~een placed upon assiniedl the name...development. anges in the electrical conduction of the sub- , se inee in which they are produced. This latter B. Explosive reactions such as benzoyl per... explosions falling over is 35 degrees. , (8) have given us some criteria for the design of Disposable transparent plastic covers have been 0 . hand-carried

  16. A Partnership Training Program in Breast Cancer Research Using Molecular Imaging Techniques

    DTIC Science & Technology

    2009-07-01

    induced in MCF-7 cells when they are co-cultured with macrophages. • We have analyzed how interactions between the MCF-7 and macrophages are...acrophages. W e have determ ined how the interactions betw een MCF-7 cells and macrophages are affected by tam oxifen and aspiri n. W e have also id...is somewhat smaller than that of the freely oscillating cantilever. Because the SPM tip interacts with the surface through various small forces, there

  17. Sleep and Alertness Management I: Pharmacokinetics of Hypnotics and Alertness Enhancers in Marmoset Monkeys (slaap- en alertheidsmanagement I: farmacokinetiek van slaap- en alertheidsverhogendemiddelen in marmosetapen)

    DTIC Science & Technology

    2006-10-01

    worden. prestaties en alertheid te optimaliseren. maken van HPLC - en GC-MS-tecbnieken. Teabahi Ervaringen met militaire missies bebben Teuttne cnlse norm...analyse van de bloedmonsters ( HPLC en GC-MS). De bloedmonsters zijn afgenomen met behuip van een stress reducerend protocol. waardoor anesthesie niet nodig...preparation and analysis ( HPLC and GC-MS) were developed by using high quality separation and detection methods. The blood samples were obtained using a

  18. Psychometric Properties of the Demographics, Temperament and Coping Scales (DTCS)

    DTIC Science & Technology

    2009-10-15

    prevalence rates, Combat and Operational S tress (COS) and its potential resultants (ranging from Combat and Opera tional Stress Reactions - COSRs to Post...Traumatic Stress Disorder - PTSD) are topics of specific interest to the Department of Defense (DoD). Three ind ividual difference factors: demographics...deployment Combat Stress Control (CSC) services scr eening instrument. This report presents data on the initial validation of these factors, which are

  19. Quantum DOT IR Photodetectors

    DTIC Science & Technology

    2012-07-01

    optics to obtain multiple spectral images. A multi-wavelength IR imager has a vast number of applications such as target detection in highly...In this section, we discuss the various electrochromic materials, their properties , and the modeling results. 4.1 ROIC Design The high-level diagram...inter- continuum DWELL any optic dependin structure thickness potential F ELL Dete new class o een propos and transitio ELL) struc 5. DWELL st

  20. China’s Growing Military Power: Perpectives on Security, Ballistic Missiles, and Conventional Capabilities

    DTIC Science & Technology

    2002-09-01

    send th e crew h om e, w h ich , once m ade, began th e search for a linguistic form ula to explain it. W as h ington h ad not, in fact...tradeoffs betw een cooperation and confrontation w ith W as h ington. In th e lexicology of C h inese analy ses, all of th ese is sues and oth ers w ere

  1. Environmental Program Management Tools for Federal Facilities

    DTIC Science & Technology

    2010-06-17

    conserve water ; r educe waste ; support susta inable communit ies; and lever age Federa l purchasing power to promote env ironment ally - responsible...Air emissions? Hazardous waste generated? – Recycling services available? – Endangered species in my area? – Where can I find waste storage...innovation and green entrepreneurship by increasing gr een procurem ent (e.g . biobased, water efficient, recycled content, Energy Star, etc.) Su

  2. Leadership for the 1970s. The Counseling Function of the Leadership Role.

    DTIC Science & Technology

    1978-11-01

    This monograph emphasizes skills as opposed to counseling ap- proaches (e.g., directive vs. non-directive) or theories (e.g., Rogerian, Gestalt ...downward, and judgmental. Whereas the leader has the opportunity to express disappointment and frustration , e~en to ventilate anger, the soldier has no...Another reprimand could seriously damage the sergeant’s career and additionally frustrate and anger both the soldier and the commander. In the actual case

  3. Bioactive Encapsulation for Military Food Applications: Request for Enhanced Nano and Micro Particle Fabrication and Characterization Facilities

    DTIC Science & Technology

    2016-01-25

    colloidal delivery systems into agglomerated powders (from Niro.com). 2 Particle Fabrication Facilities Spray drier – A small-scale spray drier was...energy nanoemulsion formation: Hydrocarbon oil, non-ionic surfactant, and water systems. Journal of Colloid and Interface Science, 425, 59-66. Komaiko...McClements, D. J. (2014b). Stabilization of vitamin E-en- riched mini-emulsions: Influence of organic and aqueous phase compositions. Colloids and Sur- faces

  4. Tactisch Optreden van kleine eenheden (Small Unit Tactics)

    DTIC Science & Technology

    2007-08-01

    van de KMar. Deze gaf onder andere de dagelijks training aan de ’Afghan National Police’ en een Psyopsteam dat met de lokale media onderhandelde...opsporingspatrouilIle. 6 De showing the flag patrouille. 7 De sociale patrouille. Hieronder worden deze patrouilles beschreven en tevens wordt aangegeven... sociale patrouille heeft bet contact onderbouden met de aanwezige bevolking ten doe]. Resultaat onderzoek: Tijdens patrouilles wordt met de plaatselijke

  5. Acta informatica medica is indexed in pubmed and archived in pubmed central.

    PubMed

    Masic, Izet

    2013-03-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

  6. A Tactile Torso Display Improves Orientation Awareness in Microgravity: A Case Study in the ISS

    DTIC Science & Technology

    2005-07-01

    omngeving beneden is. worden. kunnen de obolieten. een onderdeel van het vestihulair systeem . evenmin onder en ONGERUBRICEERD 3/36 A tactile torso display...TNO-DV3 2005 A052 6134 Contents M anagem entuittreksel ............................................................................................. 2...TNO Defence, Security and Safety Dr J.B.F. van Erp Firi author and project manager ONGERUBRICEERD ONGERUBRICEERD I TNO report I TNO-DV3 2005 A052

  7. An Automated Air Sampling System Comprising an OPTIC GC Injector I - Quantification of Soman Vapour

    DTIC Science & Technology

    2005-04-01

    declared applicable, or the relevant agreement concluded between the contracting parties. r 2005 TNO I- 2 Een geautomatiseerd luchtmonstername- systeem met...van de werkzaamheden JLN atvl Meloy-vlamfotometer ingezet die op fosfor Het OPTIC- systeem werd getest met het danwel zwavel analyseert. In de loop van...rapport bcschrijft de werking en eerste validerende tests met dit Toepasbaarheid systeem en vooruiet hiermee in deliverable Het in dit rapport

  8. Learning Effects on Strategy Selection in a Dynamic Task Environment as a Function of Time Pressure

    DTIC Science & Technology

    1994-06-01

    MANAGEMENT UI1TREKSEL Previous research on strategy selection in dynamic task environments indicated that subjects preferred to request information first...I febwari 1994 is de naam Instituut voor Zintuigfysiologie TNO gewijzigd in TNO Technische Menskunde. 2 CONTENTS Page SUMMARY 3 SAMENVAITING 4 I...waarin men gebruik maakt van de continue feedback over de toestand van het systeem . Proefpersonen moesten het veranderende conditieniveau van een atleet

  9. On the Design of a Gasgun Accelerator for Dynamic Warhead Tests

    DTIC Science & Technology

    1993-10-01

    warheadversneller- systeem is aangetoond en een aantal deelontwerpen opgesteld. Het nadere ontwerp en de constructie van het systeem lijken grotendeels binnen de...Dist Avail a~d/ior Spucial TNO-report PML. 253291358 Page 3 CONTENTS SUMMARY/SAMENVATTING 2 CONTENTS 3 1 INTRODUCTION 6 1.1 The present PML test...gasgun system for dynamic warhead tests, including 25 kf for program management INTERNAL EXTERNAL (kf) (kf) 315 335 TOTAL COST 650 12.4 Operating

  10. CBT for Nightmares in OEF/OIF Veterans

    DTIC Science & Technology

    2012-07-01

    examines the efficacy of two cognitive-behavioral treatments for PTSD-related recurrent nightmares and other sleep difficulties in Veterans of Operation...other Pos ttraumatic Stress Disorder (PTSD) symptoms. A cognitive-behavioral treatment ( CBT ), Imagery Rehearsal (IR), appears to have promise for...of treatment -related changes in nightmare frequency and sleep quality, focusing on noradrenergic systems. One hundred and fift een OEF/OIF

  11. The Bril (De Bril)

    DTIC Science & Technology

    2005-11-01

    Leidinggeven. de wijze waarop het management haar stempel drukt op de organisatie en haar functioneren. - Personeel & Opleiding. De ( typen /groepen...kunnen er grofweg drie typen van beslissingen worden onderscheiden: I Hierarchisch. De eersie of hoogsie in rang neemnt bet besluit. 2 Veto. In sommige...Larson, 1987; Moorhead & Griffin, 1995]. Afhankelijk van de situatie schrijft het model een van de vijf onderscheiden typen participatie voor. 3.2.5

  12. Verification of the Production Safe Flight Instrument Corporation OV/RV- 1D Stall Warning System

    DTIC Science & Technology

    1988-11-01

    Interchangeability, Louvered Scarfed Shroud Suppressor ( LSSS ). Prototype, Warning Margin 44 19. ABSTRACT (Continuo on niuese If necessar’y and Identify by block...conducted with the Louvered Scarfed Shroud Suppresser ( LSSS ) not installed clu toexessve ntne aceleand Tirewall temperatures previously encountered with...een (3rum- man’s test on airtraft/SN _67-18922 nd U.S. Army Aviation Engineering Flight Activity’s (AEFA’s) test on aircraft,. 62-5867 for LSSS not

  13. Research on Diamantane and other High Density Hydrocarbon Fuels.

    DTIC Science & Technology

    1979-10-01

    high-yield reaction involved the double homo Diels -Adler condensation of norbornadiene catalyzed by the system cobaltic acetylacetonate-triphenyl...the conditions of maximizing the yield of crystalline endo, tri(cyclopentadiene) (TriCPD) during the cracking and condensation of dicyclopentadiene...above ambient has-b-een shown to induce ring-opening, probably forming condensed cycloalkyladamantanes, which further lowers both viscosity and density

  14. Induction of a Pregnancy-Like Mammary Gland Differentiation by Docosapentaenoic Omega-3 Fatty Acid

    DTIC Science & Technology

    2009-09-01

    association betw een omega -3 fatty acids (n-3 PUFA ) and low er risk of breast cancer. Although experimental animal studies indicate that including n-3...1-0375 TITLE: Induction of a Pregnancy-Like Mammary Gland Differentiation by Docosapentaenoic Omega -3 Fatty Acid PRINCIPAL INVESTIGATOR...during pregnancy. Considerable evidences suggest strongly that the n-3 polyunsaturated fatty acid ( PUFA ) content of adipose breast tissue is

  15. First NATO/SIBCA Exercise in Sampling of Chemical Warfare Agents (Eerste NATO/SIBCA-oefening in monstername van chemische strijdmiddelen).

    DTIC Science & Technology

    1998-01-01

    hoog model, circa 50 liter), 3 stuks ; plastic afvalbakken (laag model, circa 30 liter), 8 stuks ; DS2-apparaten met patronen; 10 liter Saval...Voor monsters van materialen die niet of siecht in de monsterpotten kunnen worden gebracht, zoals bijvoorbeeld vegetatie of een stuk kunststof, zijn...benodigdheden voor monsterneming Bijlage 2 Materieel verzorgd door teamleden van de NBC-school materiaal voor afbakenen van terrein CAM’S, 4 stuks

  16. Strategic Capacity RNLA Central Maintenance Depot for Electronic Materials (ECW), Investigation into the Future Workload of ECW. (Strategische Omvang Elektronische Centrale Werkplaats (ECW) onderzoek naar de toekomstige werkiast van ECW)

    DTIC Science & Technology

    1998-03-01

    installatie van lokale netwerken RVS /EM Artillerie MeetMiddelen Meteo (5 stuks ) RVS MOR (3 stuks ) Geluid Meet Dienst (4 stuks ) Perba (80 stuks ) Vo-meters...200 A 300 stuks ) In tweede instantie is bezien of werkzaamheden die apart vermeld staan, tot een gemeenschappelijke technologiecel gerekend kunnen...Leopard) 12 Sensoren Meteo (5 stuks ) MOR (3 stuks ) Geluid Meet Dienst (4 stuks ) Perba (80 stuks ) VO-meters (200 ý 300 stuks ) EOV RPV 13 IT systemen

  17. Ir A.H. de Voogt: life and career of a radio pioneer

    NASA Astrophysics Data System (ADS)

    Strom, R. G.

    2007-06-01

    There are probably few radio astronomers who would be able to recall A.H. de Voogt, which is unfortunate, but at the same time unsurprising: for he published no original astronomical research, never carried out pioneering observations, nor is his name linked to either theoretical or instrumental breakthroughs. Yet he was described by the man who first observed the 21 cm hydrogen line from the Netherlands as a radio astronomy pioneer, at the very birth of the Dutch effort. He was, moreover, a trail blazer at the cutting edge of radio, not once but twice in his career. Without him it is unlikely that the 21 cm line would have been observed in the Netherlands in 1951, and arguably the H I mapping of the Milky Way under Jan Oort's leadership would have taken place much later, if at all. Radio astronomy observing itself might well have been compromised by interference had it not been for De Voogt's foresight. \\ Anthonet Hugo de Voogt (1892-1969) built, while still a teenager, one of the very first amateur radio stations (call letters VO: *** -/- - -) in Holland, earned the radio-telegrapher's diploma during his student days, and was intimately involved in the foundation of the Dutch Society for Radio-Telegraphy in 1916. Until the 1920s, he was very active in amateur radio and astronomy circles. Trained in electrical engineering at Delft, he joined the PTT (Post Office) as a telegraph engineer in 1919, worked his way through the ranks to become head of the telephone district of Breda in 1939, and was promoted to head the PTT Radio Service just days after the end of the war. As his department was responsible for overseas radio communication, he initiated a research effort to study radio propagation in the ionosphere and the effects of solar activity. To this end, he rescued a number of Würzburg-Riese 7.5-m radar antennas abandoned at the end of the war, made one available for Jan Oort's H I work, and launched a series of radio astronomical initiatives. His group also

  18. Polarimetry in the Outskirts of NGC 6611

    NASA Astrophysics Data System (ADS)

    Orsatti, Ana M.; Vega, E. Irene; Marraco, Hugo G.

    2006-11-01

    We present new polarimetric UBVRI observations of 25 stars in the direction of the halo of NGC 6611, the rich stellar open cluster embedded in an ionized hydrogen complex (M16). Our plan is to characterize the interstellar material (ISM) associated with halo stars in order to make a comparison with the ISM dusty core characteristics that resulted from a previous investigation by the same authors. Of the halo stars, 47% (8 out of 17) show indications of intrinsic polarization in their light, similar to what was found for core stars (50%). We have identified the presence of nearby dust clouds located on the Local arm that produce a mean polarization of about 1%; a value λmax=0.61+/-0.07 μm, which is slightly larger than that of the average ISM; and a mean direction of the polarization vectors of θV=81.9d+/-1.8d. The ISM associated with the halo region has λmax similar to the general interstellar medium (0.55+/-0.07 μm). The observed polarizations show a gradual increase from halo (Pmax=1.93%+/-0.3%) to core (Pmax=3.19%+/-0.63%). Position angles of the e-vector for both groups are generally similar, but there exists a slight difference in mean direction between them that is within the errors. We have also found that the halo stars are possibly represented by Whittet & van Breda's relationship, while in the cluster's core the dust does not fulfill the above-mentioned relationship. As a conclusion, we cannot find any clear difference between core and halo dust characteristics, with the exception of λmax, which may suggest a change in dust size. Based on observations obtained at Complejo Astronómico El Leoncito, operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the Universities of La Plata, Córdoba, and San Juan.

  19. Aspects théoriques et expérimentaux du dopage physique (implantation) des polymères électroactifs

    NASA Astrophysics Data System (ADS)

    Moliton, A.; Duroux, J. L.; Froyer, G.

    In this paper is presented the physicist point of view concerning the transport mechanisms and the doping of electroactive polymers, and the main results collected by physical doping (ion implantation) of these materials. In a first step, the Peierls transition is explained in the frame of solid state physics and we show by using the Hückel theory that a band gap shows up in a model atoms separated by bond lengths alternating between two values. Doping mechanisms and their effects on the band structure are presented following Bredas theory through the example of polyparaphenylene. Therefore we show that defects (polarons and bipolarons) are introduced on the chain generating localized gap states. For high level doping, bipolaron bands are obtained which partly close the gap. The second step of this paper describes the overall conduction process and not only the intrachain process. It may be explained in terms of Mott theory (variable range hoping) elaborated for amorphous semiconducting materials. From the experimental point of view, cristallographic studies performed so far show that dopants are localized in intersticial position and thus can transfer charge to the polymer chain. Some examples of implantation profiles are presented in electroactive polymers, it is possible to calculate the mean ion range from the stopping powers deduced from implantation parameters. With large implantation parameters, particularly E > 100 keV, polymer degradation becomes noticeable and is constant whatever the polymer type, electroactive or not. With smoother parameters, electroactive polymers can be doped efficiently and in a stable way allowing thus the practical formation of components which should become important in the forth coming years. Dans cet article nous présentons essentiellement du point de vue du physicien d'une part les mécanismes de conduction et de dopage des polymères électroactifs, et d'autre part les principaux résultats obtenus à la suite du dopage

  20. Early enteral nutrition after total gastrectomy for gastric cancer.

    PubMed

    Chen, Wei; Zhang, Zheng; Xiong, Maoming; Meng, Xiangling; Dai, Fen; Fang, Jun; Wan, Hong; Wang, Miaofeng

    2014-01-01

    目的:评价胃癌患者全胃切除术后,早期肠内营养(EEN)与全肠外营养 (TPN)的差异。方法:收集2011 年5 月至2013 年5 月我科收治的胃癌全胃 切除患者,术后随机选择EEN 或TPN,对EEN 组和TPN 组患者术前及术后 的营养指标、肝功能、癌症患者营养评估标准(PG-SGA)、术后并发症、住 院时间以及住院费用进行对照研究。结果:符合入选标准的胃癌全胃切除患 者共72 例,其中EEN 组37 例,TPN 组35 例。EEN 组在术后3~5 天低白蛋 白血症逐渐改善,而TPN 组术后21 天才逐渐恢复。EEN 组术后14 天体重较 术前减轻,术后21 天逐渐恢复,而TPN 组在术后21 天内体重无明显恢复 (p<0.05)。两组营养指标有明显统计学差异(p<0.05)。ENN 组和TPN 组 并发症发生率分别为8.1%和25.7%,两组间无明显统计学差异(p>0.05)。 ENN 组住院时间为12.2±2.5 天,TPN 组为14.9±2.9 天(p<0.05),ENN 组和 TPN 组住院费用分别为36472±4833 元人民币和40140±3927 元人民币 (p<0.05)。结论:与TPN 相比,胃癌全胃切除术后选择EEN 安全、患者耐 受性好,并且可以缩短住院时间,减少住院总费用。

  1. The Determination of Mustard Gas and Related Vesicants in Rubber and Paint by Gas Chromatography-Mass Spectrometry

    DTIC Science & Technology

    1992-12-01

    genomen kunnen worden op een slagveld na gebruik van chemische strijdmiddelen. Binnen bet kader van de opdracbt A84/Y,/159 ’Identificatie van chemische...publicatie gebruikt. TNO-report PML 214492016 Page 4 CONTENTS SUMMARYISAMENVATTING 2 VOORWOORD 3 CONTENTS 4 1 INTRODUCTION 5 2 EXPERIMENTAL 5 2.1...TNO-roport PNI. 2144Q 201 b imgc 12 4 AUTHENTICATION E.R. Wil H.L, Boter (author) (project manager ) TNO-report PML 214492016 Page 13 5 REFERENCES 1

  2. Projectiel Fotografie (Projectile Photography)

    DTIC Science & Technology

    1991-12-01

    Projectiel fotografie AD-A256 492 Niets uA deze uitgave mag worden atu~) vermenigvuldigd en/of openbaar gemaakf ueut) door middel van druk, fotokopie...N - Approved for Pubbiee) 9212 38 DisfiTN@Q ThO rapport Pagina 2 rapport no. . FEL-91-AO80 Accesion For Miel Projectiel fotografie NTIS CRA&I DTIC...purpose. TNO rapport Pagina 4 SAMENVATTING 2 ABSTRACT 3 INHOUDSOPGAVE 4 1 PROJECTIEL FOTOGRAFIE 5 2 DE OPBOUW VAN EEN TV SYSTEEM 7 2.1 De triggerpoort 8

  3. [TALE nuclease engineering and targeted genome modification].

    PubMed

    Shen, Yan; Xiao, An; Huang, Peng; Wang, Wei-Ye; Zhu, Zuo-Yan; Zhang, Bo

    2013-04-01

    Artificial designer nucleases targeting specific DNA sequences open up a new field for reverse genetics study. The rapid development of engineered endonucleases (EENs) enables targeted genome modification theoretically in any species. The construction of transcription activator-like effector nucleases (TALENs) is simpler with higher specificity and less toxicity than zinc-finger nucleases (ZFNs). Here, we summarized the recent progresses and prospects of TALEN technology, with an emphasis on its structure, function, and construction strategies, as well as a collection of species and genes that have been successfully modified by TALENs, especially the application in zebrafish.

  4. Ozone Ageing of Silicone Rubber and the Effects of Anti-Oxidants on the Ozone Ageing of Nitrile Rubber.

    DTIC Science & Technology

    1981-04-01

    APR 81 UNCLASSIFIED RAE-TM-MAT-369 DRIC-BR-87489 F/G 11/10 NL mEEns MEOMOEEhMImIIIIIIIIIIIEIIIIII 1.0 SIIIII . ’ + 1.8 11112 1.4 11111_L6 l~y k ~IT N i...graphs follow a characteristic curve of ozone attack on rubber. Table I is a representation of the retention of physical properties of the rubbers...TEST) ozone resistance. Silicone rubber. Nitrile rubber. 17. Abstract Work done by others suggested that a rapid lose of physical properties could occur

  5. Aircraft Handling Qualities Data

    DTIC Science & Technology

    1972-12-01

    34 sent an early estimate in the design process and perhaps the "nominal config- uration" is one which never left the drawing board. The data have been...09 * P 0,0 04@0 in WP5 5 4.55 *55 a0p @4 4.em #50 a,45 05555 eO-aO* ൈ 04 40 C’ L tip- left -ൌ It U4 - - -amw --- - - 2 - -- 4 -4 A-a A22 * ~127... seEen -ts and a movable stabilizer. The lateral con- trol empl(ys five srciler ;anels, an inboard aileron between the inboard and outboard flars, and an

  6. Boosting Immune Responses Against Bacterial Pathogens: In Vitro Analysis of Immunomodulators (In Vitro Analyse van de Stimulerende Werking van Verschillende Stoffen op het Immuunsysteem)

    DTIC Science & Technology

    2007-07-01

    Distribution list Onderstaande instanties/personen ontvangen een volledig exernplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie...Directeur Militaire Gezondheidszorg 9 CDCIBGGZ Kol-arts H.A. Gerretsen MPH 10 CDCfBGGZ/CEMG A.S. de Koning, arts standaard inclusief digitale versie...Ltkol C.A. Bourgondie n standaard inclusief digitale versie bijgeleverd op cd-rom 16 Mindef/DMO/DWS&B/RLS&B/Logistieke systemen Kol ir. M.B.G. Mulder

  7. Environmental Assessment. Proposed Air Force Space Division Housing Project, White Point, Los Angeles, California

    DTIC Science & Technology

    1984-07-01

    cottoitail Sylvilagus auduboni 1 s9een A A runs California g-round squirrel Citellus beechc-yi skulls A A in owl pellets burrows--i recent kill seen...0 . o 0 0 .>L0 ý’ aC - 4) -Gof ’,~*4H-3r--.n ml~𔃺 I I- I The following is a report of the nature of archeological resources on and adjacent to Fort...furnished by vilsey and Ham. Study Method No archeological survey of the Palos Verdes Hills, in which the study areas are located, has been published

  8. Unsteady Airloads on a Sinusoidally Oscillating Supercritical Airfoil.

    DTIC Science & Technology

    1979-07-01

    hodograph method of Boerstoel Codes i/or ( Ref. 1). e𔃻" l (*) At present Dr. Yoshihara is employed by the Boeing Co. -3-- rMemorandum AE-79-01 5 Emphasis...nas een performed on a-model of an oscillating supercritical airfoil, 7f which the geometry has been generated with tne hodograph method of Boerstoel ...Te:argest -teviatilons sn’- JW Up r--rte ar ru"r of i arC-’ 1, -..- ero rie . r C-acun1t’e, ;a’ a ar-e bowto" calculated cu;rve. Near th -sun e,4,,, he niessur

  9. Dynamic Displays for Tactical Planning. Volume 3. Software Documentation

    DTIC Science & Technology

    1979-12-01

    ANtj E EV EfTS DU, I NG (,’C iF L -9L AY fp SP,)27 )u ~T’ PLi MAALNT=Lij CALL t3ULT 1- I ITS.( 2) .AD.l I Soil 3)) kLA ( 19, i ~)E* LY 70o FL- vkt ;AT(Ui...Tu CiSTFRUCT A jvuI A dEThEEN t, A42. 9j,-)’j C ***USING THE FUNCTIUN KEY’iJARC) IN A CALCULATOR PAD TYPE FuKIm;r C (** CALCULATOR TYPE PAD AT RIGHT

  10. Tussenrapportage Validatie Onderwijsvernieuwingen (Validation Assistant in Instructional Design)

    DTIC Science & Technology

    2007-05-01

    Research Kampweg 5 Postbus 23 3769 ZG Soesterberg TNO-rapport wwton T 034 635 62 11 TNO- DV 2007 All F 034 635 39 77info- DenV@tno. n I Tussenrapportage...te vergemakkelijken zou in TNO-rapportnummer meer detailinformatie nodig heeft om een de opleiding tot opleidingsontwikkelaars TNO- DV 2007 Al 11...invulling en dle voortgang van het dr. M.L. van Emmerik onderzoek. M.G. van Schalk TNO0-rapport I TNO- DV 2007 Al 11 4/29 Samenvatting Vraagstelling Op

  11. Refined Genetic Algorithms for Polypeptide Structure Prediction.

    DTIC Science & Technology

    1996-12-01

    designing no v el proteins, in deco ding the information obtained from the Human Genome Pro ject (91), in designing new drugs, and in trying to...function that assigns tness v alues to p ossible solutions and an enco de/ deco de b et w een the algorithm and problem spaces. Al- though these metho ds...genetic algorithms: In tro duction and o v erview of curren t researc h. Parallel Genetic Algorithms, pages 5{35, 1993. 22. Bruce S. Duncan . P arallel ev

  12. Neutron fluxes in radiotherapy rooms.

    PubMed

    Agosteo, S; Foglio Para, A; Maggioni, B

    1993-01-01

    The spatial distribution of the neutron flux, originated in an electron accelerator therapy room when energies above the threshold of (y,n) and (e,e'n) reactions are employed, is physically due to a direct flux, coming from the accelerator head, and to a flux diffused from the walls. In this work, the flux is described to a high degree of approximation by a set of functions whose spatial behavior is univocally determined by the angular distributions of the neutrons emitted from the shield of the accelerator head and diffused from the walls. The analytical results are verified with an extended series of Monte Carlo simulations obtained with the MCNP code.

  13. Literature Review of Five Metabolites of TNT or DNT.

    DTIC Science & Technology

    1981-10-01

    IJNCLA SIFED SN -AD-F500 151 0/ 6 6 L E~mhhhhEENE -ti LI 1111 U~ 2.2 11111.25 IJI Ihi6 MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARDS...E3IGro 1. REONME E "Mea GOVT ACCESSION NO:. RECIPIENT S CATALOG NUMBER NSWc/r 82-308 14. TITLE (an &uils)*. L . TYPE OF REPORT a PERIOD COVERED LITERATURE...3 IR (KBr)(cm-): 3300b, 3275s, 3070, 1525 4 1330, 1008, 893, 840, 7q5, 720 A-1 -,------ ? ,,j, L , , - ,’... . . . .. .. . . . " .7 ), a ..e

  14. Diterpenoid derivatives of Kenyan Croton sylvaticus.

    PubMed

    Ndunda, Beth; Langat, Moses K; Midiwo, Jacob O; Omosa, Leonidah K

    2015-04-01

    Kenyan Croton sylvaticus Hochst. ex Krauss gave four clerodane diterpenoids, the new ent-3,13E-clerodadiene-15-formate (1), the known 15-acetoxy-ent-3,13E-clerodadiene (2), ent-3,13E-clerodadien-15-ol (3) and hardwickiic acid (4), two known halimane diterpenoids, penduliflaworosin (5) and crotohalimaneic acid (6) and one labdane diterpenoid, labda-13E-ene-8a,15-diol (7). The compounds, when tested for their anti-microbial activities against Bacillus subtilis, Xanthomonas campestris and Candida albicans, were found to be inactive.

  15. Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida.

    PubMed

    Pellati, Federica; Calò, Samuele; Benvenuti, Stefania; Adinolfi, Barbara; Nieri, Paola; Melegari, Michele

    2006-07-01

    Bioassay-guided fractionation of n-hexane extracts of Echinacea pallida (Asteraceae) roots led to the isolation and structure elucidation of two polyacetylenes (1, 3) and three polyenes (2, 4, 5). Two are known hydroxylated compounds, namely 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2). Two dicarbonylic constituents, namely pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3) and pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4), were isolated and characterized for the first time. Furthermore, the structure elucidation of pentadeca-(8Z,13Z)-dien-11-yn-2-one (5) is described. The structure of the compounds isolated was determined on the basis of UV, IR, NMR (including 1D and 2D NMR experiments, such as 1H-1H gCOSY, gHSQC-DEPT, gHMBC, gNOESY) and MS spectroscopic data. The cytotoxic activity of the isolated constituents against MIA PaCa-2 human pancreatic adenocarcinoma cells was evaluated in the concentration range 1-100 microg/ml. Results show that the hydroxylated compounds (1, 2) have low cytotoxicity, while the more hydrophobic polyacetylenes (3) and polyenes (4, 5) displayed moderate activity.

  16. Nutrition in Pediatric Inflammatory Bowel Disease: From Etiology to Treatment. A Systematic Review

    PubMed Central

    Penagini, Francesca; Dilillo, Dario; Borsani, Barbara; Cococcioni, Lucia; Galli, Erica; Bedogni, Giorgio; Zuin, Giovanna; Zuccotti, Gian Vincenzo

    2016-01-01

    Nutrition is involved in several aspects of pediatric inflammatory bowel disease (IBD), ranging from disease etiology to induction and maintenance of disease. With regards to etiology, there are pediatric data, mainly from case-control studies, which suggest that some dietary habits (for example consumption of animal protein, fatty foods, high sugar intake) may predispose patients to IBD onset. As for disease treatment, exclusive enteral nutrition (EEN) is an extensively studied, well established, and valid approach to the remission of pediatric Crohn’s disease (CD). Apart from EEN, several new nutritional approaches are emerging and have proved to be successful (specific carbohydrate diet and CD exclusion diet) but the available evidence is not strong enough to recommend this kind of intervention in clinical practice and new large experimental controlled studies are needed, especially in the pediatric population. Moreover, efforts are being made to identify foods with anti-inflammatory properties such as curcumin and long-chain polyunsaturated fatty acids n-3, which can possibly be effective in maintenance of disease. The present systematic review aims at reviewing the scientific literature on all aspects of nutrition in pediatric IBD, including the most recent advances on nutritional therapy. PMID:27258308

  17. Chemosystematic investigations of irregular diterpenes in Anisotome and related New Zealand Apiaceae.

    PubMed

    Zidorn, Christian; Sturm, Sonja; Dawson, John W; van Klink, John W; Stuppner, Hermann; Perry, Nigel B

    2002-02-01

    A chemosystematic HPLC-UV and HPLC-MS investigation of New Zealand members of the Apiaceae was performed. Diterpenes were identified and quantified in methanolic extracts from subaerial parts of 28 taxa and 54 samples of Aciphylla, Anisotome, Apium, Gingidia, Lignocarpa, Oreomyrrhis, and Scandia. Six diterpenes (1-2, 4-7) and four polyacetylenes (8-11) were identified. The known compounds were the diterpenes anisotomenoic acid 1, anisotomene-1-ol 2, 16-acetoxyanisotomenoic acid 4 and anisotomene-1,12-diol 5; and the polyacetylenes falcarinol 8, falcarindiol 9, (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol 10, and (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol 1-acetate 11. New irregular diterpenes 13,14-dihydroanisotom-12E-ene-1,14-diol 6 and 14-methoxy-13,14-dihydroanisotom-12E-ene-1-ol 7 were isolated from A. haastii. Isomers of the new semi-synthetic diterpene 16-hydroxyanisotomenoic acid 3 were detected in extracts of Anisitone flexuosa. Structure elucidation was performed by HR mass spectrometry and 1D and 2D NMR spectroscopy. In crude extracts, compounds were identified by their HPLC retention times and their on-line HPLC-UV and MS spectra. Anisotomene diterpenes occurred in eight out of 16 species of the genus Anisotome, but were not detected in any of the other genera. In contrast, polyacetylenes were present in all the genera investigated.

  18. Design, syntheses, and properties of tunable, dual-stimuli (temperature and pH) responsive copolymers

    NASA Astrophysics Data System (ADS)

    Manokruang, Kiattikhun

    polymer aggregates for each pH, rather than random/polydisperse structures. TEM images of the collapsed morphology showed polymer aggregates that included numerous small hydrophobic cores, demonstrating that the phase transition of these copolymers involved the formation of micelles with many hydrophobic clusters. Finally, these copolymers were used to prepare hollow microcapsules that provided an exceptional protection and a prolonged stability of an encapsulated matter at acidic conditions (pH 2) and a sharp and fast pH-triggered release at physiological conditions (pH 7). A second series of copolymers was synthesized to compose of ethylene glycol oligomers (EOm) connected in an alternating fashion with hydrophobic alkyls (EEn), (EOm-alt-EE n). Also, terpolymers were synthesized to compose of EOm connected in an alternating fashion with EEn and lysine ethyl ester (LyE), (EOm-alt-(EEn;LyE). Both copolymers and terpolymers demonstrated temperature responsive LCST phase behavior in aqueous solution, whose critical temperature is dictated by the thermodynamics of the hydrophilic/hydrophobic balance. In addition, the terpolymers' LCST can be further tuned by tailoring the ratio of EEn to LyE yielding dual responsive, viz. temperature and pH responsive, polymers upon conversion of LyE to ionizable Lysine (Lys). These last polymers that included ionizable units showed a reversible temperature and pH sensitive phase transition, allowing for such polymers to exhibit a phase separation with both-or-either temperature increase and pH-decrease. The extended phase diagrams, collected from turbidity measurements and modulated differential scanning callorimetry (MDSC), showed that the phase diagram remained a genuine LCST binodal throughout the complete concentration range. In addition, 1H-NMR provided additional strong evidence that the phase transition proceeded without micelle formation. Finally, hydrogels were prepared from EOm-alt-EEn, which exhibited reversible swelling

  19. Compatibility study and adaption of stone repair mortars for the Lede stone (Belgium)

    NASA Astrophysics Data System (ADS)

    De Kock, T.; Vandevoorde, D.; Boone, M. A.; Dewanckele, J.; De Boever, W.; Lanzón, M.; De Schutter, G.; Van Hoorebeke, L.; Jacobs, P.; Cnudde, V.

    2012-04-01

    One of the main historic building materials in northern Belgium is the Lede stone. This arenaceous limestone from Lutetian age was excavated in the region of Ghent and Brussels and was transported northwards by main rivers such as the Scheldt and Zenne. Thanks to this natural transport route, the stone in also found in many cities which lie abroad the excavation area, such as Antwerp (Belgium) and various cities in the Netherlands (Breda, Zierikzee, …). Due to its dominant occurrence in our cultural heritage, it is frequently subjected to restoration and renovation works. Depending on the degree of decay, most frequent stone operations are cleaning, healing with mortar or replacing it by (often exotic) fresh blocks. Originally, this limestone has a greenish-gray colour, but when being exposed to atmospheric conditions it acquires a yellowish to rusty coloured patina. The origin of the latter is most likely the oxidation of glauconite minerals which are present in a few percent in the stone. In addition, the stone often demonstrates black crust formation due to sulphation. Cleaning of the stone often results in an excess removal of this black gypsum crusts and patina, thus exposing deeper parts of the stone which appear more greenish-gray again. When the stone is subsequently healed by adding repair mortar to damaged parts, the question rises which mortar colour is more appropriate. The choice of repair mortar is greatly depending on commercial aspects. When handling entire facades on monuments, a mineral mortar based on ZnCl is most often applied in Belgium. The big advantage of this mortar is its fast curing. Three colour types have been developed for the Lede stone in specific. However, the hardness of this mortar is sometimes in conflict with reversibility. For the handling of individual sculptures some conservators choose for the application of (hydraulic) lime mortars. The advantage of using such mortars is their high compatibility and reversibility. The

  20. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio.

    PubMed

    Wu, Xiaoyi; Chao, Zhimao; Wang, Chun; Yu, Li

    2015-03-06

    A solvent system of n-hexane, methyl acetate, acetonitrile, and water at a novel volume ratio of 4:3:4:4 forms three layers, i.e. upper phase (UP), middle phase (MP), and lower phase (LP), with a volume ratio of 1:1.20:1.42 at room temperature (25°C). All three two-phases from this three-phase solvent system were successfully used to separate some chemical constituents from three plant medicines with counter-current chromatography (CCC). Eight coumarins (B1-B8) were obtained from petroleum ether extract of fresh roots of Angelica dahurica (Baizhi) with a stationary phase of UP and a mobile phase of LP. Six diarylheptanoids (L1-L6) were obtained from petroleum ether extract of dried rhizomes of Alpinia officinarum (Liangjiang) with a stationary phase of UP and a mobile phase of MP. Three chemical constituents (Z1-Z3) were obtained from ethyl acetate extract of fresh rhizomes of Anemarrhena asphodeloides (Zhimu) with a stationary phase of MP and a mobile phase of LP. Preparative HPLC was used for further purification if necessary. Seventeen chemical constituents were identified as oxypeucedanin hydrate (B1), byakangelicin (B2), byakangelicol (B3), bergapten (B4), oxypeucedanin (B5), imperatorin (B6), phellopterin (B7), isoimperatorin (B8), 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone (L1), 7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-4E-en-3-heptanone (L2), 5-hydroxy-1,7-diphenyl-3-heptanone (L3), 1,7-diphenyl-4E-en-3-heptanone (L4), 5-hydroxy-1,7-diphenyl-4E,6E-dien-3-heptanone (L5), isomers of 1,7-diphenyl-3,5-heptandione and 5-hydroxy-1,7-diphenyl-4E-en-3-heptanone (L6), mangiferin (Z1), timosaponin A-III (Z2), and 2,6,4'-trihydroxy-4-methoxy-benzophenone (Z3) by means of MS, (1)H and (13)C NMR studies. Five compounds of B3, L3, L5, L6, and Z3 were isolated by CCC for the first time.

  1. Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae).

    PubMed

    Rios, María Yolanda; Aguilar-Guadarrama, A Berenice; Gutiérrez, María Del Carmen

    2007-03-21

    Heliopsis longipes (Compositae) is a Mexican plant used as analgesic in pain toothache. A solution of 10mug/ml of dichloromethane extract from this plant showed analgesic activity determined by means of GABA release in mice brain slices. Through a bioassay-directed separation, fractions G-1, G-2, G-4 and G-6 at the same concentration were active. Affinin was the unique and common active compound, and evoke the GABA release 0.5min after administration at 1x10(-4)M concentration. Inactive compound were undeca-2E-en-8,10-dyinoic acid isobutylamide, hinokinin, 2'-hydroxyhinokinin, 3beta-sn-glyceroyl-(1''-palmitoxy)urs-12-ene, 13(18)-ursen-3beta-ol, 13(18)-ursen-3beta-acetate, beta-sitosterol and stigmasterol. The analgesic activity of Heliopsis longipes could be associated to affinin.

  2. Applications of Multiconductor Transmission Line Theory to the Prediction of Cable Coupling. Volume 5. Prediction of Crosstalk Involving Twisted Wire Pairs

    DTIC Science & Technology

    1978-02-01

    ADES1dfeetf, GV C CESgIiON NO e) . SRECUIET CAS.fTALOG NUMEoRt a6. OSR Y9 TIO T TE MENDIT I ofA I tOITPLINGrt) I?.:ico ofTF Cross T EEN tle Ibntolvtineg i Blok...equations and resulting chain parameter matrix for the single wire receptor model, one can characterize an electrically short Ax section of the line...jW-GIG(x) - J(I)2mIR(x) (2-la) dx dRx ) -j~ 2 ml(X) -jWLRIR(X) (2-1b) dx dI(x) jW(cG + cm) VG x + jWcmVR W (2-c) dI-R W jwcmVG(x) -jw(cR + cm) VR(X) (Z

  3. Epoxidation reactions of unsaturated fatty esters with potassium peroxomonosulfate.

    PubMed

    Lie Ken Jie, M S; Pasha, M K

    1998-06-01

    Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave the corresponding monoepoxy derivatives. Reaction of Oxone with methyl linoleate and octadeca-9Z,11E-dienoate furnished the corresponding diepoxystearate derivative. Methyl 9,12-dioxo-octadec-10Z-enoate was obtained when a C18 furanoid fatty ester (methyl 9,12-epoxy-9,11-octadecadienoate) was treated with Oxone. The yield of these reactions was very high (85-99%), and the epoxy derivatives were readily isolated by solvent extraction. The products were identified by spectroscopic methods.

  4. STS-112 crew arrives at KSC's SLF for launch

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-112 Mission Specialist Fyodor Yurchikhin, who is with the Russian Space Agency, shows his happiness at returning to KSC to prepare for launch. He will be making his first Shuttle flight. STS-112, aboard Space Shuttle Atlantis, is the 15th assembly mission to the International Space Station. Atlantis will be carrying the S1 Integrated Truss Structure, the first starboard truss segment, to be attached to the central truss segment, S0, and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. The 11-day mission includes three spacewalks. Launch is scheduled for Oct. 2 betw een 2 and 6 p.m.

  5. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Daychem Laboratories Inc. - Elbeck Enterprises Inc.). Part 6

    DTIC Science & Technology

    1994-03-01

    4.-4 Lai 0 OO c.. H 1 00 0(E1) C en NEE)Een ) cn cE)cE ) eVCE n ) E cE) ECV)CE on _jNcEl ) t) m E)C cm) I- m E nen) 0 H I CO00(E) II 00000000 0000000...NOPNM MN-NNNNN ft .. .. fNP P. NN NNP% .Nr. MM NF% NM NP .M P. r. P.P% . 44 ) M ’v ) M )v 4’ )e N-4:10,0-4NO 00 0 0 0 00 0 0 0 0 00 0 0 0 00 0 0 0 0

  6. Species Differences in the Disposition and Metabolism of 2,4,6-Trinitrotoluene as a Function of Route of Administration.

    DTIC Science & Technology

    1981-06-01

    commercial suppliers. Swiss albino CD1® mice (20 to 30 g) and Sprague-Dawley CD@ rats (200 to 300 g) were purchased from Charles River Breeding Laboratories...e sat sea eateca aaCt MtMtn*Mea Nt r.tt .NeN eeN ttNtN- *- t-t--t- t-. 278t taet atee eaa aatt aat aetetta teea tea *e..a~ea ee..eae~ a aaa...aa~~aa~ aaa e~...............°*eaee teaa+aeea ta .. ,,, tatte .,+ et .13 tattetta t aa aa aa a- * tattoo 1 tat tea t-...... at ., a = d’+ a~rU -+ c

  7. High Latitude Electron Detectors on Satellite P78-1: Preliminary Data Results.

    DTIC Science & Technology

    1981-05-04

    t r5 ’n 01i ON STA rA1 ME4 T -j lII~ EHpoaI A plpi we~d fl - publIo -C -rloa se; d I sI -i butfl . ii I I I cd. 01 S’ .1 BRj :Ol STA T E.EN I !h1 b ...V- PIe. ’Aceer~sion For NTIS GRA&I DT I ,T A B Unamonead J"m jf I (!,t ion- S-Dist r~ibut ionl/ AVail.1bili ty Codes ’Availl and/or Dis~t Special...Timne, Kp 1 8a . Di ffe rent ial 1Electron Spectria From B ~oth Deitetors Taken at Cort-erted Geomnagnet ic Latitude, 6G;411’ Northern Nights ide Auror-a

  8. Manufacturing Methods and Technology Project Execution Report.

    DTIC Science & Technology

    1985-04-01

    IMPLEMENT THE MACHINE TCUL INTL PRL.DUCITuN. 6 3U oCL𔃾 H- IGri :iPL.Eb ABkAflIVE BELT QiNuii’G THE MACH IN’E HAS BEEiv MOVE,) uN SPOiT ANL) INSTAL.LATION 1S...6C38 H IGri uEPO..IT ION W4ELu IU C WuRK LCMPLEIEO ALL WELD _ iE.TLD SATiSFALTURILY F~ik mELD QUALITY -u BALLISTIC INTEGkITY. THt ABOVE CONTRACT VALUE...MOULE SCANNER PERFORMANCE TH1S EFFORT PRODUCE. AN CU’MMO1 t MODUL.E SCANNER ACCEPTAiCt TESTER. THE TECHNICAL W2’RK HA.S bEEN COIMPLETED. THE FliAL

  9. Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer.

    PubMed

    Li, B; Liu, H Y; Guo, S H; Sun, P; Gong, F M; Jia, B Q

    2015-06-29

    The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa-tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment. Patients' clinical outcomes, post-operative immune function, and nutritional statuses were compared, which revealed that the postoperative fever duration (80.2 ± 6.0 vs 88.1 ± 8.1 h, P < 0.05), anal exhaust time (78.8 ± 9.3 vs 85.3 ± 8.4 h, P < 0.05), and length of hospitalization (7.73 ± 2.13 vs 9.77 ± 1.76 days, P < 0.01) differed significantly. Treatment costs in thousands of dol-lars were 31.24 ± 3.21 for the experimental group and 35.61 ± 2.32 for the control group; this difference was statistically significant (P < 0.01). The incidence of postoperative complications did not significantly differ between the experimental and control groups [14.0% (21/150) vs 17.3% (26/150), P > 0.05]. At postoperative days 3 and 7, the CD3(+), CD4(+), natural killer cell, albumin, and prealbumin levels and CD4(+)/CD8(+) ra-tio were significantly higher in the experimental group than the control group (all P < 0.05). CD8(+) cell counts were significantly lower in the experimental group than the control group (P < 0.05). Postsurgical oral EEN can improve nutritional status and immune function and promote early recovery of intestinal function in patients with gastric cancer.

  10. The growth and reproduction performance of TALEN-mediated β-lactoglobulin-knockout bucks.

    PubMed

    Ge, Hengtao; Cui, Chenchen; Liu, Jun; Luo, Yan; Quan, Fusheng; Jin, Yaping; Zhang, Yong

    2016-10-01

    With the technological development of several engineered endonucleases (EENs), such as zinc-finger nucleases, transcription activator-like effector nucleases (TALENs) and CRISPR/Cas9, gene targeting by homologous recombination has been efficiently improved to generate site-specifically genetically modified livestock. However, few studies have been done to investigate the health and fertility of these animals. The purpose of the present study is to investigate if gene targeting events and a recloning procedure would affect the production traits of EEN-mediated gene targeted bucks. TALEN-mediated β-lactoglobulin (BLG) gene mono-allelic knockout (BLG (+/-)) goats and bi-allelic knockout (BLG (-/-)) buck produced by using sequential gene targeting combined with recloning in fibroblasts from BLG (+/-) buck were used to evaluate their health and fertility. Birth weight and postnatal growth of BLG (+/-) bucks were similar to the wild-type goats. None of the parameters for both fresh and frozen-thawed semen quality were significantly different in BLG (+/-) or BLG (-/-) bucks compared to their corresponding comparators. In vitro fertilization (IVF) test revealed that the proportion of IVF oocytes developing to the blastocyst stage was identical among BLG (+/-), BLG (-/-) and wild-type bucks. Conception rates of artificial insemination were respectively 42.3, 38.0 and 42.6 % for frozen-thawed semen from the BLG (+/-), BLG (-/-) and wild-type bucks. In addition, germline transmission of the targeted BLG modification was in accordance with Mendelian rules. These results demonstrated that the analyzed growth and reproductive traits were not impacted by targeting BLG gene and recloning, implicating the potential for dairy goat breeding of BLG (+/-) and BLG (-/-) bucks.

  11. Cytotoxic benzophenone and triterpene from Garcinia hombroniana.

    PubMed

    Jamila, Nargis; Khairuddean, Melati; Yaacob, Nik Soriani; Kamal, Nik Nur Syazni Nik Mohamed; Osman, Hasnah; Khan, Sadiq Noor; Khan, Naeem

    2014-06-01

    Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to investigate the bioactive chemical constituents of the bark of G. hombroniana. Ethyl acetate and dichloromethane extracts of G. hombroniana yielded two new (1, 9) and thirteen known compounds which were characterized by the spectral techniques of NMR, UV, IR and EI/ESI-MS, and identified as; 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone(1), 2,3',4,4'-tetrahydroxy-6-methoxybenzophenone (2), 2,3',4,6-tetrahydroxybenzophenone (3), 1,3,6,7-tetrahydroxyxanthone (4), 3,3',4',5,7-pentahydroxyflavone (5),3,3',5,5',7-pentahydroxyflavanone (6), 3,3',4',5,5',7-hexahydroxyflavone (7), 4',5,7-trihydroxyflavanone-7-rutinoside (8), 18(13→17)-abeo-3β-acetoxy-9α,13β-lanost-24E-en-26-oic acid (9), garcihombronane B (10), garcihombronane D (11), friedelan-3-one (12), lupeol (13), stigmasterol (14) and stigmasterol glucoside (15). In the in vitro cytotoxicity against MCF-7, DBTRG, U2OS and PC-3 cell lines, compounds 1 and 9 displayed good cytotoxic effects against DBTRG cancer cell lines. Compounds 1-8 were also found to possess significant antioxidant activities. Owing to these properties, this study can be further extended to explore more significant bioactive components of this plant.

  12. Multi-resolution Analysis of the slip history of 1999 Chi-Chi, Taiwan earthquake

    NASA Astrophysics Data System (ADS)

    Ji, C.; Helmberger, D. V.

    2001-05-01

    Studies of large earthquakes have revealed strong heterogeneity in faulting slip distributions at mid-crustal depths. These results are inferred from modeling l ocal GPS and strong motion records but are usually limited by the lack of data density. Here we report on the fault complexity of the large (Magnitude 7.6) Chi- Chi earthquake obtained by inverting densely and well distributed static measure ments consisting of 119 GPS and 23 doubly integrated strong motion records, whic h is the best static data set yet recorded for a large earthquake. We show that the slip of the Chi-Chi earthquake was concentrated on the surface of a "wedge shaped" block. Furthermore, similar to our previous study in 1999 Hector Mine ea rthquake (Ji et al., 2001), the static data, teleseismic body wave and local str ong motion data are used to constrain the rupture process. A simulated annealing method combined with wavelet transform approach is employed to solve for the sl ip histories on subfault elements with variable sizes. The sizes are adjusted it eratively based on data type and distribution to produce an optimal balance betw een resolution and reliability. Results indicate strong local variations in rupt ure characteristics with relatively rapid changes in the middle and southern por tion producing relatively strong accelerations.

  13. E nergetic Particles As Tracers Of Magnetic Connectivity And Solar Injectio n

    NASA Astrophysics Data System (ADS)

    Malandraki, O. E.; Lario, D.; Kelin, K.-L.; Marsden, R. G.; Heber, B.; Sarris, E. T.; Geranios, A.

    2007-01-01

    Advances exp ected in solar energetic par ticle (SEP) research in the contex t of possible observ ations with the Solar Orb iter (SO LO) and Inner Heliospheric Sentinels (IHS) are presen ted. Sin ce propag ation effects ar e expected to hav e a mu ch smaller inf luence on par ticle profiles closer to the Sun, SEP observations ob tained with SO LO and IHS w ill provide a more accurate estimation of the onset times of SEP even ts and enable the separation of differ ent EP in jections. Fine-time resolution SEP measuremen ts obtained by SO LO and IHS along with more detailed information on solar activ ity available from SOLO, from other spacecraft, and from ground-based instrumen ts, comp ared e.g. to Helios, w ill mak e possible important investigations of the r elative timing of in jection betw een energetic electrons and ions in close link age w ith th e p lasma and radiation conditions in their source regions on the Sun. The in tensities and angular distributions of near- relativistic electrons will also be used to provide information con cerning the n ear-Sun connectivity of Interplanetary Magnetic Field lin es threading through Interplanetary Coronal Mass Ejections in the inner helio sphere.

  14. Word Frequency Analysis. MOS: 75B. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    COMMAND FORT MONROE, VIRGINIA 23651 _N -- SEP 1 W %r 4 4Ř A~ 9b AT oP 70311 0 .1 ft I.t...oI3 ~ PREPARED BY: OPERATIONS DIV. DPFOCOY...C tS ItI 2 iaL...P v 9 r 1 A e 2 G R S S 1 G ..I C E 5 2 H A N n I J N O 14EEN2 GUIDE I H ’irL ED 0 HAPPENS0 G, lu..t,CF WIAN’ 4 wk;vdt.a1rEN I HAV INtG 1 HAIDS 63M...SLED t 1 1 . 1 m/pImAt, 1 IN7RODUCTIDN 2 Issue 11 ITEPS I I T’AlSI1 I ISO 21 IyEt I 11 vi IS 1 IT’S 7 JAwI jD1P1 ŕ 11 9 IV I J’IVED-DVEj JUN z ItS

  15. A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides.

    PubMed

    Hartog, Anita; Belle, Fabiën N; Bastiaans, Jacqueline; de Graaff, Priscilla; Garssen, Johan; Harthoorn, Lucien F; Vos, Arjan P

    2015-03-01

    Inflammatory bowel diseases (IBD) including ulcerative colitis (UC) and Crohn's disease (CD) are chronic relapsing inflammatory disorders of the gastrointestinal tract. The interaction between a disturbed microbial composition, the intestinal mucosal barrier and the mucosal immune system plays an important role in IBD and its chronicity. It has been indicated that due to the altered microbial composition the balance between T regulatory cells (Treg) and T helper cells (Th) 17 is disturbed, leading to an inflammatory state. The present study shows that oral intake of a specific multi fibre mix (MF), designed to match the fibre content of a healthy diet, counteracts IBD-like intestinal inflammation and weight loss in dextran sodium sulphate treated mice. This reduction in inflammation might be brought about, at least in part, by the MF-induced decrease in inflammatory cytokines, increase in IL-10 and the relative increase in Treg cells in the mesenteric lymph nodes (MLN). Moreover, the Treg percentage in the MLN correlates with the percentage of tolerogenic lamina propria derived CD103+RALDH+dendritic cells in the MLN, suggesting that these play a role in the observed effects. In children with CD exclusive enteral nutrition (EEN) is a widely used safe and effective therapy. Optimizing enteral nutritional concepts with the tested fibre mix, know to modulate the gut microbiota composition, SCFA production and inflammatory status (as indicated by the present study) could possibly further improve efficacy in inducing remission.

  16. Women and men in science: creating equal opportunities

    NASA Astrophysics Data System (ADS)

    Slomp, Caroline P.

    2016-04-01

    In the Netherlands, 17% of professors are women This is one of the lowest percentages for countries in the EU, placing the Netherlands at position 24 in a total of 27. The percentage of women professors is gradually increasing, but at the current growth rate, a gender balance cannot be expected to be reached before 2055 (LNVH, 2015). This underrepresentation of women in leadership positions is all the more surprising given the nearly equal numbers of male and female students at universities already since the end of the 1980s (CBS, 2010). In my presentation, I will give a personal perspective on the barriers that women face when pursuing a career in science and the types of bias encountered, with specific attention to the role of cultural stereotypes and how these impact the day-to-day life of women in science and contribute to the loss of very talented researchers. I will also discuss strategies that can be developed to work around such issues and the need for further changes in research funding schemes. Finally, I urge both men and women to always speak up when they observe gender bias, for example when women are being overlooked as plenary speakers at conferences, for awards and fellowships, as project or discussion partners and leaders, for positions and for promotion. References: LNVH (Dutch Network of Women Professors), 2015, Monitor Vrouwelijke Hoogleraren. http://www.lnvh.nl CBS (Statistics Netherlands), 2010. Terugblkken. Een eeuw in statistieken. http://www.cbs.nl

  17. Th and U fuel photofission study by NTD for AD-MSR subcritical assembly

    NASA Astrophysics Data System (ADS)

    Sajo-Bohus, Laszlo; Greaves, Eduardo D.; Davila, Jesus; Barros, Haydn; Pino, Felix; Barrera, Maria T.; Farina, Fulvio

    2015-07-01

    During the last decade a considerable effort has been devoted for developing energy generating systems based on advanced nuclear technology within the design concepts of GEN-IV. Thorium base fuel systems such as accelerator driven nuclear reactors are one of the often mentioned attractive and affordable options. Several radiotherapy linear accelerators are on the market and due to their reliability, they could be employed as drivers for subcritical liquid fuel assemblies. Bremsstrahlung photons with energies above 5.5MeV, induce (γ,n) and (e,e'n) reactions in the W-target. Resulting gamma radiation and photo or fission neutrons may be absorbed in target materials such as thorium and uranium isotopes to induce sustained fission or nuclear transmutation in waste radioactive materials. Relevant photo driven and photo-fission reaction cross sections are important for actinides 232Th, 238U and 237Np in the radiotherapy machines energy range of 10-20 MV. In this study we employ passive nuclear track detectors (NTD) to determine fission rates and neutron production rates with the aim to establish the feasibility for gamma and photo-neutron driven subcritical assemblies. To cope with these objectives a 20 MV radiotherapy machine has been employed with a mixed fuel target. Results will support further development for a subcritical assembly employing a thorium containing liquid fuel. It is expected that acquired technological knowledge will contribute to the Venezuelan nuclear energy program.

  18. High-performance liquid chromatography analysis of polyacetylenes and polyenes in Echinacea pallida by using a monolithic reversed-phase silica column.

    PubMed

    Pellati, Federica; Calò, Samuele; Benvenuti, Stefania

    2007-05-11

    In this study, a RP-HPLC method for the analysis of polyacetylenes and polyenes in Echinacea pallida roots and phytopharmaceuticals was developed. The reference compounds used for quantification were isolated from the plant material and their structures were determined on the basis of the analysis of UV, IR, NMR and MS data. The complete structure elucidation of three compounds, namely 8-hydroxy-tetradec-(9E)-ene-11,13-diyn-2-one (1), tetradec-(8Z)-ene-11,13-diyn-2-one (6) and pentadec-(8Z)-en-2-one (9) is described. In the analysis of the n-hexane extracts of E. pallida roots, the comparison between conventional and monolithic columns showed that the elution order in both cases is identical and the selectivity is equivalent. However, the retention times achieved by the monolithic column are shorter, resulting in a faster separation (20 min). Therefore, the analyses were carried out on a Chromolith Performance RP-18e (100 mm x 4.6 mm i.d.), with a gradient mobile phase composed by H(2)O and ACN at the flow rate of 2 mL/min. The column was thermostatted at 20 degrees C. The photodiode array detector monitored the eluent at 210 nm. The validation procedure confirmed that this technique affords reliable analysis of these components and is appropriate for the quality control of complex matrices, such as E. pallida roots and phytopharmaceuticals.

  19. Interannual and Annual Variations in the Mediterranean Sea from Satellite Altimetry and Grace Data

    NASA Astrophysics Data System (ADS)

    Garcia, D.; Vigo, I.; Chao, B. F.; Del Río, J.

    2006-07-01

    More than a decade of altimetry data h ave been used to develop thr ee studies in the Med iterranean Sea (and Black sea wh en feasible). Firstly, sea level v ariations (SLV) data from 49 tide g auge ( TG) stations along th e North Med iterranean and Black Sea coast have been compared to close SLV measurements from altimetry. From those compar isons, vertical crustal motions at th e TG sites have b een inf erred. Secondly , in terannual SLV have been explored in the Mediterran ean and Black Sea. A kink of tendency in mid-1999 is observed in sev eral regions of the Med iterranean and in the Black Sea. Thirdly, th e steric and eustatic terms of the annual SLV of the Mediterr anean has been inferred from time- variab le gravity (TVG) data and temperature (T) and salinity (S) profiles. It has been inf erred that the SLV are main ly driven by steric SLV, wh ich are par tially offset by w ater mass changes.

  20. Cembrane-type diterpenoids from the Chinese liverworts Chandonanthus hirtellus and C. birmensis.

    PubMed

    Li, Rui-Juan; Lin, Zhao-Min; Kang, Ya-Qi; Guo, Yan-Xia; Lv, Xin; Zhou, Jin-Chuan; Wang, Song; Lou, Hong-Xiang

    2014-02-28

    Six new cembrane-type diterpenoids (1-6) were isolated from two species of Chandonanthus: Chandonanones A, B, and D-F (1, 2, and 4-6) were isolated from C. hirtellus, and chandonanones B, C, E, and F (2, 3, 5, and 6) from C. birmensis. Five known diterpenoids, (8E)-4α-acetoxy-12α,13α-epoxycembra-1(15),8-diene (7), isochandonanthone (8), chandonanthone (9), anadensin (10), and 2,10,14-triacetoxy-7,8,18,19-diepoxydolabell-3(E)-ene (11), were also obtained. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). The absolute configurations of compounds 1 and 2 were unequivocally confirmed using single-crystal X-ray diffraction analysis with Cu Kα radiation. Cytotoxicity tests of the isolated diterpenoids against seven cancer cell lines (DU145, PC3, A549, PC12, NCI-H292, NCI-H1299, and A172) revealed that some of the diterpenoids had weak activity.

  1. Support for EU fundraising in the field of Environment & Energy - BayFOR

    NASA Astrophysics Data System (ADS)

    Ammerl, Thomas; Baumann, Cornelia; Reiter, Andrea; Blume, Andreas; Just, Jana; Franke, Jan

    2013-04-01

    Contract negotiations with the European Commission e) Project implementation (Project management, dissemination, Science-Policy-Interface) BayFOR staff has profound R&D background, as well as knowledge and experience in disseminating project outcomes, in particular with regard to the adaptation of results to the needs of relevant target groups like science, industry/SMEs, policy makers and the public. Furthermore, BayFOR can draw on distinct experience in the management of European research projects (e.g. CLIMB, Largecells, AlpBC, GeoMol, WE-EEN, WINALP). As a partner in the network for SMEs "Enterprise Europe Network" (EEN), BayFOR offers advice and support on topics such as funding, research programs, public procurement, market penetration and the promotion of innovation at European level. Beyond, BayFOR will make use of its regional networks to promote uptake and exploitation of project results. BayFOR is also commissioned by Bavaria's State Ministry of Science, Research and the Arts to look after the Bavarian University Funding Programme for the Initiation of International Projects (BayIntAn). Our efforts are aimed at initiating or strengthening transnational collaborative research involving Bavarian universities and universities of applied sciences.

  2. Timelike Compton Scattering off the nucleon: observables and experimental perspectives for JLab at 12 GeV

    SciTech Connect

    Boer, Marie

    2016-03-01

    Hard exclusive processes such as photoproduction or electroproduction of photon or meson off the nucleon provide access to the Generalized Parton Distributions (GPDs), in the regime where the scattering amplitude is factorized into a hard and a soft part. GPDs contain the correlation between the longitudinal momentum fraction and the transverse spatial densities of quarks and gluons in the nucleon. Timelike Compton Scattering (TCS) correspond to the reaction gammaN --> gamma*N --> e+e?N, where the photon is scattered off a quark. It is measured through its interference with the associated Bethe-Heitler process, which has the same final state. TCS allows to access the GPDs and test their universality by comparison to the results obtained with the DVCS process (eN --> e gamma N). Also, results obtained with TCS provide additional independent constrains to the GPDs parameterization. We will present the physical motivations for TCS, with our theoretical predictions for TCS observables and their dependencies. We calculated for JLab 12 GeV energies all the single and double beam and/or target polarization observables off the proton and off the neutron. We will also present the experimental perspectives for the next years at JLab. Two proposals were already accepted at JLab: in Hall B, with the CLAS12 spectrometer, in order to measure the unpolarized cross section and in Hall A, with the SoLID spectrometer, in order to measure the unpolarized cross section and the beam spin asymmetry at high intensity. A Letter Of Intent was also submitted in order to measure the transverse target spin asymmetries in Hall C. We will discuss the merits of this different experiments and present some of the expected results.

  3. Probing the darkness : the link between baryons and dark matter

    NASA Astrophysics Data System (ADS)

    Velliscig, Marco

    2015-11-01

    De meeste materie in ons Universum is donker. Deze donkere materie vormt de bouwsteen van de grootschalige, kosmische structuren, waarin sterrenstelsels leven. Door zijn botsingloze natuur is donkere materie namelijk beter in staat structuren te vormen dan normale ("baryonische") materie. Deze structuren bestaan uit vlakken, filamenten en knopen, die samen ook wel het kosmisch web worden genoemd. Sterrenstelsels bewonen de centra van grotere "halo's" van donkere materie. Deze halo's zijn zelf niet zichtbaar en het licht uitgezonden door sterrenstelsels kan ons alleen iets vertellen over het binnendeel van deze halo's. In dit proefschrift trachten we meer over halo's te weten te komen. Hiertoe maken we gebruik van kosmologische, hydrodynamische simulaties, waarin we niet alleen de donkere maar ook de zichtbare materie meenemen, alsmede alle processen die gedacht worden belangrijk te zijn voor de vorming en groei van sterrenstelsels. Dergelijke simulaties bieden ons de mogelijkheid om het verband tussen zichtbare en donkere materie te verkennen, aangezien beide componenten tegelijk en zelfconsistent worden gesimuleerd. In waarnemingen kan dit verband onderzocht worden door gebruik te maken van zwaartekrachtlenzen. De werking van dergelijke lenzen is gebaseerd op de afbuiging van fotonen (lichtdeeltjes) wanneer deze door een zwaartekrachtspotentiaal reizen. Zodoende ondervindt licht dat van ver in het heelal naar ons toe reist, onderweg verschillende kleine afbuigingen. Als gevolg hiervan zien wij het beeld van de bron als verplaatst, vergroot en verstoord. Het zwaartekrachtlenseffect kan gebruikt worden om verschillende eigenschappen van (materie in) het Universum te meten, waaronder de totale massa en het massaprofiel van halo's, de vormen van halo's, de efficientie van de vorming van sterrenstelsels en uiteindelijk ook de fundamentele kosmologische parameters van ons Universum. Door gebruik te maken van kosmologische, hydrodynamische simulaties kunnen we ook

  4. Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients with Prolonged Fasting.

    PubMed

    Xi, Fengchan; Li, Ning; Geng, Yanxia; Gao, Tao; Zhang, Juanjuan; Jun, Tanshan; Lin, Zhiliang; Li, Weiqin; Zhu, Weiming; Yu, Wenkui; Li, Jieshou

    2014-05-01

    Although different studies suggest that early enteral nutrition (EEN) has benefits in reducing infectious complications, there is no data that addresses whether delayed enteral nutrition (EN) is detrimental and if it may have effects on inflammatory responses and immune function. Forty-five critically ill patients with long fasting were randomly allocated in two groups according to the type of nutritional support. The first group included patients assuming a standard enteral nutrition (EN, n = 22) and the second group assuming a parenteral nutrition (PN, n = 23). The daily nutritional amount was 25 kcal (105 kJ)/kg for all patients. The inflammatory markers white blood cells (WBC), C-reactive protein (CRP), TNF-α, IL-1-β, IL-6, IL-4, IL- 10 and the immune T-lymphocyte sub-populations CD3+, CD4+, CD8+, and HLA-DR+ were evaluated at day 1, and after 2, 3 and 7 days. IL-4, IL-10, CD3+, CD4+, CD8+ and the CD4+/CD8+ ratio were not statistically different between the two groups. WBC and TNF-α in EN patients were higher than those in PN after 3 and 7 days (P < 0.05). CRP and IL-6 levels were higher in EN patients than those assuming a PN after 2 and 3 days (P < 0.05). HLA-DR levels in patients assuming an EN were found higher than those in PN at day 7 (P < 0.05). Delayed EN for critically ill patients with long-term fasting increased systemic inflammatory responses, whereas EN could modify immune function, therefore reducing hospital stay and costs.

  5. Present and Future Automotive Composite Materials Research Efforts at DOE

    SciTech Connect

    Warren, C.D.

    1999-07-03

    Automobiles of the future will be forced to travel fi.uther on a tank of fuel while discharging lower levels of pollutants. Currently, the United States uses in excess of 16.4 million barrels of petroleum per day. Sixty-six percent of that petroleum is used in the transportation of people and goods. Automobiles currently account for just under two-thirds of the nation's gasoline consumptio~ and about one-third of the total United States energy usage. [1] By improving transportation related fiel efficiency, the United States can lessen the impact that emissions have on our environment and provide a cleaner environment for fiture generations. In 1992, The Department of Energy's (DOE) Office of Transportation Materials completed a comprehensive program plan entitled, The Lightweight MateriaIs (LWko Multi-Year Program Plan, for the development of technologies aimed at reducing vehicle mass [2]. This plan was followed in 1997 by the more comprehensive Office of Advanced Automotive Technologies research and development plan titled, Energy Eficient Vehicles for a Cleaner Environment [3] which outlines the department's plans for developing more efficient vehicles during the next ~een years. Both plans identi~ potential applications, technology needs, and R&D priorities. The goal of the Lightweight Materials Program is to develop materials and primary processing methods for the fabrication of lighter weight components which can be incorporated into automotive systems. These technologies are intended to reduce vehicle weight, increase fuel efficiency and decrease emissions. The Lightweight Materials program is jointly managed by the Department of Energy(DOE) and the United States Automotive Materials Partnership (USAMP). Composite materiak program work is coordinated by cooperative research efforts between the DOE and the Automotive Composites Consortium (ACC).

  6. A Combined Use of Decomposition and Texture for Terrain Classification of Fully Polarimetric SAR Images

    NASA Astrophysics Data System (ADS)

    Rodionova, N. V.

    2007-03-01

    This p aper presents two-stag e unsupervised terrain classification of fully polarimetr ic SA R data using Freeman and Durden decomposition based on three simp le scattering mechanisms: surface, volume and double bounce (first step), and textur al features (uncorrelated uniformity , contr ast, inv erse mo men t and entropy) obtained from grey lev el co-occurrence matr ices (GLCM) (second step). Textural f eatures ar e defined in moving w indow 5x5 pixels w ith N=32 (N - number of grey lev els) . This algorith m preserves th e purity of domin ant polarimetric scattering properties and defines textural features in each scatter ing category. It is shown better object discrimin ation after app lying textur e w ith in fix ed scattering category. Speckle r eduction is one of th e main mo ments in imag e interpr etation improvement because of its great influen ce on textur e. Results from unfiltered and Lee filtered polar imetr ic SAR imag es show that the v alues of contrast and en tropy decr ease and th e values of uniformity and inverse moment increase with speckle reduction, that's tru e for all polarizations (HH, VV, HV). Th e d iscr imination b etw een objects increases after speckle f ilter ing. Polar ization influen ce on textur e features is def ined by calculating th e features in SAR images w ith HH , VV and HV polarizations before and after speck le filter ing, and then creating RG B images. It is shown mor e polarization inf luence on textur e features (uniformity , inverse mo ment and entropy) before filtering and less influen ce - after speck le f iltering. I t's not true for contrast wher e polar ization influen ce is not ch anged practically w ith filtering. SIR-C/X-SA R SLC L-band imag es of Moscow r egion are used for illustr ation.

  7. Thermal and epithermal neutron fluence rate gradient measurements by PADC detectors in LINAC radiotherapy treatments-field

    NASA Astrophysics Data System (ADS)

    Barrera, M. T.; Barros, H.; Pino, F.; Dávila, J.; Sajo-Bohus, L.

    2015-07-01

    LINAC VARIAN 2100 is where energetic electrons produce Bremsstrahlung radiation, with energies above the nucleon binding energy (E≈5.5MeV). This radiation induce (γ,n) and (e,e'n) reactions mainly in the natural tungsten target material (its total photoneutron cross section is about 4000 mb in a energy range from 9-17 MeV). These reactions may occur also in other components of the system (e.g. multi leaf collimator). During radiation treatment the human body may receive an additional dose inside and outside the treated volume produced by the mentioned nuclear reactions. We measured the neutron density at the treatment table using nuclear track detectors (PADC-NTD). These covered by a boron-converter are employed, including a cadmium filter, to determine the ratio between two groups of neutron energy, i.e. thermal and epithermal. The PADC-NTD detectors were exposed to the radiation field at the iso-center during regular operation of the accelerator. Neutron are determined indirectly by the converting reaction 10B(n,α)7Li the emerging charged particle leave their kinetic energy in the PADC forming a latent nuclear track, enlarged by chemical etching (6N, NaOH, 70°C). Track density provides information on the neutron density through calibration coefficient (˜1.6 104 neutrons /track) obtained by a californium source. We report the estimation of the thermal and epithermal neutron field and its gradient for photoneutrons produced in radiotherapy treatments with 18 MV linear accelerators. It was obsered that photoneutron production have higher rate at the iso-center.

  8. A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.

    PubMed

    Sharma, Neeraj; LaRusch, Jessica; Sosnay, Patrick R; Gottschalk, Laura B; Lopez, Andrea P; Pellicore, Matthew J; Evans, Taylor; Davis, Emily; Atalar, Melis; Na, Chan-Hyun; Rosson, Gedge D; Belchis, Deborah; Milewski, Michal; Pandey, Akhilesh; Cutting, Garry R

    2016-12-01

    The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1). In this study, we explored whether COOH-terminal sequences in CFTR beyond the PDZ-binding motif influence its interaction with NHERF1. NHERF1 displayed minimal self-association in blot overlays (NHERF1, Kd = 1,382 ± 61.1 nM) at concentrations well above physiological levels, estimated at 240 nM from RNA-sequencing and 260 nM by liquid chromatography tandem mass spectrometry in sweat gland, a key site of CFTR function in vivo. However, NHERF1 oligomerized at considerably lower concentrations (10 nM) in the presence of the last 111 amino acids of CFTR (20 nM) in blot overlays and cross-linking assays and in coimmunoprecipitations using differently tagged versions of NHERF1. Deletion and alanine mutagenesis revealed that a six-amino acid sequence (1417)EENKVR(1422) and the terminal (1478)TRL(1480) (PDZ-binding motif) in the COOH-terminus were essential for the enhanced oligomerization of NHERF1. Full-length CFTR stably expressed in Madin-Darby canine kidney epithelial cells fostered NHERF1 oligomerization that was substantially reduced (∼5-fold) on alanine substitution of EEN, KVR, or EENKVR residues or deletion of the TRL motif. Confocal fluorescent microscopy revealed that the EENKVR and TRL sequences contribute to preferential localization of CFTR to the apical membrane. Together, these results indicate that COOH-terminal sequences mediate enhanced NHERF1 interaction and facilitate the localization of CFTR, a property that could be manipulated to stabilize mutant forms of CFTR at the apical surface to maximize the effect of CFTR-targeted therapeutics.

  9. Terpenoids from Leaves of Guarea macrophylla Display In Vitro Cytotoxic Activity and Induce Apoptosis In Melanoma Cells.

    PubMed

    Conserva, Geanne Alexandra A; Girola, Natalia; Figueiredo, Carlos R; Azevedo, Ricardo A; Mousdell, Sasha; Sartorelli, Patricia; Soares, Marisi G; Antar, Guilherme M; Lago, João Henrique G

    2017-04-10

    Guarea macrophylla is a Brazilian plant species that has been used in folk medicine to treat a range of diseases. Our ongoing work focuses on the discovery of new bioactive natural products derived from Brazilian flora. The current study describes the identification of cytotoxic compounds from the EtOH extract of leaves from G. macrophylla using bioactivity-guided fractionation. This approach resulted in the isolation and characterization of four compounds: cycloart-23E-ene-3β,25-diol (1), (23S*,24S*)-dihydroxycicloart-25-en-3-one (2), isopimara-7,15-diene-2α,3β-diol (3), and isopimara-7,15-dien-3β-ol (4), in which 2 and 3 are identified as new derivatives. In vitro assays were conducted to evaluate the cytotoxic activity of compounds 1-4 against a panel of cancer cell lines and to determine the possible mechanism(s) related to the activity of the compounds on B16F10Nex2 cells. The most active compound 1 induced cytotoxic effects on tumor cells, with IC50 values of 18.3, 52.1, and 58.9 µM against HL-60, HeLa, and B16F10-Nex2 tumor cells, respectively. Furthermore, it was observed in melanoma cells that compound 1 induced several specific apoptotic hallmarks, such as morphological changes in the cell shape structure, nuclear DNA condensation, specific chromatin fragmentation, and disruption in the mitochondrial membrane potential, which are related to the intrinsic apoptotic pathway.

  10. Emulation of an ensemble Kalman filter algorithm on a flood wave propagation model

    NASA Astrophysics Data System (ADS)

    Barthélémy, S.; Ricci, S.; Pannekoucke, O.; Thual, O.; Malaterre, P. O.

    2013-06-01

    parametrized variance and correlation length scale with a diffusion operator makes it possible to model the converged background error covariance matrix from the EnKF without actually integrating the EnKF algorithm. This method was finally applied to a case with two different observation point with different error statistics. It was shown that the results of this emulated EnKF (EEnKF) in terms of background error variance, correlation length scale and analyzed water level is close to those of the EnKF but with a significantly reduced computational cost.

  11. Radio Sounding Techniques for the Galilean Icy Moons and their Jovian Magnetospheric Environment

    NASA Technical Reports Server (NTRS)

    Green, James L.; Markus, Thursten; Fung, Shing F.; Benson, Robert F.; Reinich, Bodo W.; Song, Paul; Gogineni, S. Prasad; Cooper, John F.; Taylor, William W. L.; Garcia, Leonard

    2004-01-01

    Radio sounding of the Earth's topside ionosphere and magnetosphere is a proven technique from geospace missions such as the International Satellites for Ionospheric Studies (ISIS) and the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE). Application of this technique to Jupiter's icy moons and the surrounding Jovian magnetosphere will provide unique remote sensing observations of the plasma and magnetic field environments and the subsurface conductivities, of Europa, Ganymede, and Callisto. Spatial structures of ionospheric plasma above the surfaces of the moons vary in response to magnetic-field perturbations from (1) magnetospheric plasma flows, (2) ionospheric currents from ionization of sputtered surface material, and (3) induced electric currents in salty subsurface oceans and from the plasma flows and ionospheric currents themselves. Radio sounding from 3 kHz to 10 MHz can provide the global electron densities necessary for the extraction of the oceanic current signals and supplements in-situ plasma and magnetic field measurements. While radio sounding requires high transmitter power for subsurface sounding, little power is needed to probe the electron density and magnetic field intensity near the spacecraft. For subsurface sounding, reflections occur at changes in the dielectric index, e.g., at the interfaces between two different phases of water or between water and soil. Variations in sub-surface conductivity of the icy moons can be investigated by radio sounding in the frequency range from 10 MHz to 50 MHz, allowing the determination of the presence of density and solid-liquid phase boundaries associated with oceans and related structures in overlying ice crusts. The detection of subsurface oceans underneath the icy crusts of the Jovian moons is one of the primary objectives of the Jupiter Icy Moons Orbiter (JIMO) mission. Preliminary modeling results show that return signals are clearly distinguishable be&een an ice crust with a thickness of

  12. Experiences on Altimeter Calibration at Ibiza Island and Cape of Begur (Spain)

    NASA Astrophysics Data System (ADS)

    Martinez Benjamin, J. J.; Martinez Harcia, M.; Ortiz Castello, M. A.; Talaya, J.; Baron, A.; Rodriguez Velasco, G.; Martín Davila, J.; Garate, J.; Bonnefond, P.; Garcia, C.

    2006-07-01

    Three preliminary camp aigns for TOPEX /POSEIDON (T/P) wer e made in March 1999 and July 2000 and for JASON-1 in August 2002, in the NW Mediterran ean Sea at th e Begur Cape area. Dir ect abso lute altimeter calibration , and mapping of the sea surface, w ere made in these camp aigns from dir ect overflights using GPS buoys with a toroidal design performed at the I CC based in the orig inal design of the Univ ersity of Colorado at Boulder and a estimation of the TOPEX A lt- B bias w as made. A Spanish JASON-1 geoid gradien t campaign with Fench support has been made in June 2003 at the Ibiza island in the NW Mediterr anean Sea. Th e main objectiv e has b een to map w ith a new d esign ed, builded and calibrated GPS catamar an, the lo cal geoid gradien t in three ar eas around Ibiza island under the ascending (187) and descending (248) Jason-1ground tracks. The catamaran equ ipped with two GPS antennas to perform continuous sea lev el measur ements was towed by the Patro l Dev a from th e Span ish N avy. Five GPS reference stations were dep loyed on Ibiza island: one in Portinatx, two in San Anton io and two in Ibiza. The marin e geo id has been used to relate the coastal tide gauge data from Ibiza and San An tonio h arbours to off- shore altimetric data. In th e framework of the campaign, the levelling of the Ibiza and San Anton io tide gauges to the r espective GPS mark ers w as p erformed. We present synth esis of the resu lts obtained from Topex/Poseidon and th e first r esults on Jason-1 altimeter calibration using the direct measurements from GPS buoys and the derived marin e geoid. Th e Ibiza results agree relativ ely w ell with resu lts ob tained at Corsica, Harvest and Bass Strait calibration permanen t sites. Moreov er, the geod etic activities (e.g., GPS, levelling) has p ermitted to build a very accurate (few mm) local n etwork link ed to th e European one, w ith a reference frame compatible with th e satellite altimetry missions (ITRF2000). The GPS

  13. Hartley and Itokawa: small comet and asteroid with similar morphologies and structures

    NASA Astrophysics Data System (ADS)

    Kochemasov, G. G.

    2011-10-01

    " Orbits ma ke s tructures " [1-3]. This three-word sentence means that as all cosmic bodies moves in non-circular keplerian orbits they all are subjected to an action of inertia -gravity warping waves. These waves arise in bodies as a result of periodically changing accelerations causing inertia-gravity forces. These forces are absorbed by bodies masses and make them to warp. This warping is smoothed by gravity making globular shapes of the larger bodies. But smaller bodies with rather weak gravity keep their warped shapes. The wave nature warping happens in four interfering direct ions (ortho - and diagonal) and in various wavelengths. The fundamental wave 1 long 2π R makes ubiquitous tectonic dichotomy: an oppos ition of the uplifted segment-hemisphere and the subsided one. For small bodies a result of this is in their convexo-concave shape [3] (Fig. 1-7). The uplifted bulging segment expands and is breaking by cracks, faults, rifts. The opposed subsided concave segment contracts. As a result in the middle of an oblong body is formed a narrow thoroughly squeezed and degassed portion - a neck or waist (wringed out wet linen). Subsequently here at a weakened place could happen a break - formation of binaries, polycomponental bodies, satellites. Figures 1 to 4 show development stages of small bodies leading to a full separation of two parts. Traces of warping waves of four directions are often seen on surfaces of many celestial bodies as cross -cutting lineations. A recent example of the small core of the Hartley 2 comet (2 km long) is very impressive. At received points of view are clearly seen at least three ortho- and diagonal lineations often marked by small outgassing craters (Fig. 1). Crossing lineations produce square forms (craters ) earlier s een on the Eros ' s urface. Wave comp res s ion lineations make the Hart ley 2 t o appear as a wafer ca ke. A " wa is t" (neck) is formed as a res ult of nearing a concave depression, from one side, and deep cracks

  14. PRESENT; PREScription of Enteral Nutrition in pediaTric Crohn's disease in Spain.

    PubMed

    Navas-López, Victor Manuel; Martín-de-Carpi, Javier; Segarra, Oscar; García-Burriel, José Ignacio; Díaz-Martín, Juan José; Rodríguez, Alejandro; Medina, Enrique; Juste, Mercedes

    2014-03-01

    : La frecuencia de empleo de la NEE en pacientes con EC es similar a la de otros cuestionarios europeos. Se precisan herramientas y recursos que faciliten la aceptación por parte del paciente y de su familia así como disponer de más tiempo a dedicar para instaurar esta modalidad terapéutica. Dada la disparidad de criterios para la indicación de la EEN, sería útil disponer de guías de práctica clínica ampliamente aceptadas o protocolos que facilitan la decisión de utilizarla.