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Sample records for koolipraktika kui otsustav

  1. [Investigation of JinKui ShenQi pills by ultraviolet spectra and tandem mass spectrometry].

    PubMed

    Li, Wen-lan; Sun, Zhi; Cheng, Bin; Ji, Yu-bin; Bai, Jing

    2008-08-01

    On the base of establishing the fingerprint of JinKui ShenQi pills, the ultraviolet spectra-mass spectrometry/mass spectrometry, method was used to identify the fingerprint. Seperation was performed on the Symmetry Shield RP18 (5 microm, 4. 6 mm X 15 mm) analytical column with mobile phase consisting of 1% acetic acid and acetonitrile with gradient elute at the flow rate of 1.0 mL x min(-1), and the ultraviolet detection wavelength was set at 248 nm. Using the above-mentioned chromatographic condition, the fingerprint of different samples was established and the same fingerprint was defined. The fingerprints of different samples were compared with similarity evaluation software published by Pharmacopeia committee codex (2004A). The mass spectrograph with API-ESI ionization source was used, setting the flow rate at 0.5 mL x min(-1) after splitting stream. The pressure of atomization room was 50 Psi, the flow rate of dry gas was 9.0 L x min(-1), the capillary voltage was 4 kV, and the transmission voltage was 70 V. The negative scanner mode was chosen, scan scope was 100-2000, using ion trap to analyze quasimolecular ion peak and the selected fragment ion, and TIC chromatography and second order mass chromatogram were recorded. The major constituents among in JinKui ShenQi pills from different origins were separated well by HPLC. Although there was difference among different origins, they showed nineteen identical characteristic absorption bands. Three fingerprints chemical compositions such as loganin, cinnamal and paeonol were identified based on the retention time and ultraviolet spectra of standard preparation. According to their ultraviolet spectra, molecular weight and fragmentation information, ten peaks in the fingerprint were identified by ultraviolet spectroscopy-mass, spectrometry/massg spectrometry. They are 1,2,3-tri-O-galloyl-glucose, loganin, paeoniflorin, 1,2,3,6-tetro-O-galloyl-glucose, soya-cerebroside, cornuside, and PGG, benzoyl

  2. Classrooms in the Wild: Learning Language and Life Skills in the KUIS Outdoor Sports Circle.

    ERIC Educational Resources Information Center

    Wurr, Adrian

    The role of outdoor education activities in the Kanda University English language institute is described. The outdoor program was developed to unite faculty and students interested in recreational activities and provide an opportunity to explore common interests in nature, sports, and language learning. The activities develop self-esteem,…

  3. Materials Data on KUI3O11 (SG:61) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-04-06

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. A Survey of the Application of Multimedia in the Process of Teaching and Learning in KUiTTHO, Malaysia

    ERIC Educational Resources Information Center

    Kamaruddin, Nafisah Kamariah Md; Hamid, Mohd Zaidi Bin Abdul

    2005-01-01

    Scientific research shows that the process of remembering done in the human brain is faster when people receive many emphasizes in various forms for a short period. The concept of interactivity in multimedia helps the human brain to improve the process of learning. In addition, different approaches of multimedia make lessons very entertaining…

  5. Photoelectric observations of lunar occultations. XI

    NASA Astrophysics Data System (ADS)

    Edwards, D. A.; Evans, D. S.; Fekel, F. C.; Smith, B. W.

    1980-04-01

    Occultation observations of 466 events are presented. These include diameter measures of Aldebaran under very bad conditions and a good diameter measure of 82 Vir. The list includes 91 reappearances and observations of 34 double or multiple stars, both new and previously known. The inconsistencies of the observations of Kui 88 are discussed. Further observations are most desirable.

  6. DETECTION OF K-RAS AND P53 MUTATIONS IN SPUTUM SAMPLES OF LUNG CANCER PATIENTS USING LASER CAPTURE MICRODISSECTION MICROSCOPE AND MUTATION ANALYSIS

    EPA Science Inventory

    Detection of K-ras and p53 Mutations in Sputum Samples of Lung Cancer Patients Using Laser Capture Microdissection Microscope and Mutation Analysis

    Phouthone Keohavong a,*, Wei-Min Gao a, Kui-Cheng Zheng a, Hussam Mady b, Qing Lan c, Mona Melhem b, and Judy Mumford d.
    <...

  7. Translating Policies into Practice: Culturally Appropriate Practices in an Atayal Aboriginal Kindergarten Program in Taiwan

    ERIC Educational Resources Information Center

    Chang, Cecilia Lingfen

    2005-01-01

    This article discusses the Atayal aboriginal kindergarten program in Taiwan, known as the Kui-whai kindergarten program. While teaching a course on "Designing Kindergarten Curriculum" at a teacher-training program in Taiwan, the author realized that she had seven aboriginal preservice teachers in her class; previously she had none. Those…

  8. DETECTION OF K-RAS AND P53 MUTATIONS IN SPUTUM SAMPLES OF LUNG CANCER PATIENTS USING LASER CAPTURE MICRODISSECTION MICROSCOPE AND MUTATION ANALYSIS

    EPA Science Inventory

    Detection of K-ras and p53 Mutations in Sputum Samples of Lung Cancer Patients Using Laser Capture Microdissection Microscope and Mutation Analysis

    Phouthone Keohavong a,*, Wei-Min Gao a, Kui-Cheng Zheng a, Hussam Mady b, Qing Lan c, Mona Melhem b, and Judy Mumford d.
    <...

  9. Influence of Mansonella perstans microfilaraemia on total IgE levels in Gabonese patients co-infected with Loa loa.

    PubMed

    Bouyou-Akotet, M K; Moussavou Boussougou, M N; Ovono-Abessolo, F; Owono-Medang, M; Kombila, M

    2014-03-01

    Mansonella (M.) perstans filariasis is widely found in Africa, including Gabon where Loa loa is also endemic. This study reports the total IgE titres according to different bioclinical forms of single or co-infection with L. loa and M. perstans in 138 patients and 20 healthy controls. The median parasite density was significantly higher in cases of loiasis. IgE titres were higher in patients with microscopic dual-infection and in the group of patients with occult loiasis plus M. perstans microfilaraemia (8425 [5292-20,679]KUI/L and 6304 [1045-10,326]KUI/L, respectively), compared to individuals with either microfilaraemic Loa loa (3368 [1414-7074]KUI/L) or Mansonella (4370 [1478-7334]KUI/L) single infections (p<0.01). IgE levels were positively correlated with M. perstans microfilaraemia (rho=0.27; p<0.01). Compared to single infections, dual M. perstans-L. loa infection induces very high total IgE titres. Studies correlating IgE titres and clinical symptoms are needed to confirm the involvement of this immunoglobulin in the pathological processes during filariasis. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Photoelectric observations of lunar occultations

    NASA Technical Reports Server (NTRS)

    Fekel, F. C.; Montemayor, T. J.; Barnes, T. G., III; Moffett, T. J.

    1980-01-01

    Photoelectric observations of 13 lunar occultation disappearances during a March 1979 Hyades passage are reported. Three double stars (SAO 93925 = Fin 342 = 70 Tau, SAO 93961 = ADS 3248, and SAO 95419 = Kui 24) and one possible double (SAO 93950 = 75 Tau) were detected. A brief description is given of the Purdue University pulse-counting photometer as modified for occultation observations.

  11. Mafic rocks from Erinpura gneiss terrane in the Sirohi region: Possible ocean-floor remnants in the foreland of the Delhi Fold Belt, NW India

    NASA Astrophysics Data System (ADS)

    Pandit, M. K.; de Wall, H.; Daxberger, H.; Just, J.; Bestmann, M.; Sharma, K. K.

    2011-08-01

    A small isolated mafic body occurs to the south of Sirohi near village Daba within the Neoproterozoic Erinpura Granite in the southern sector of the Proterozoic Delhi Fold Belt in NW India. This mafic body occurs close to a 100 m wide NE-SW trending shear zone (Daba Shear Zone) which overprints the felsic rock fabrics. Further south, a small mafic body near village Kui was also sampled which forms the southern limit of the Phulad Ophiolite Suite which is a 300 km long major NE-SW trending lineament, described as Western Margin Fault. Some of the lithological components of the Daba mafic body show locally preserved magmatic fabric but completely transformed mineralogies under lower amphibolites facies metamorphic conditions where two-stage deformation has been inferred. Magnetic fabric analysis underlines a general correspondence of structural elements in both felsic and mafic lithologies. Binary correlations of Zr with other high field strength elements underline fractionation as the main process in the evolution of Daba and Kui rocks. Geochemical characteristics indicate subalkaline tholeiitic basalt affinity for these mafic rocks. The trace element characteristics, such as enriched LIL elements, high Th, absence of negative Nb anomalies and depletion in compatible elements in Daba samples suggest an enriched mantle source and lower degree of melting. The trace and rare earth element characteristics for Kui (Th anomaly, Nb-Ta trough and less spiked patterns, flat REE trends) indicate derivation from a refractory mantle source affected by fluids derived from subduction. Distinct differences in trace and REE characteristics between Daba and Kui can be interpreted in terms of different stages of ophiolite development.

  12. Improving English and Chinese Ad-hoc Retrieval: Tipster Text Phase 3

    DTIC Science & Technology

    1998-10-01

    IMPROVING ENGLISH AND CHINESE AD-HOC RETRIEVAL: TIPSTER TEXT PHASE 3 FINAL REPORT Kui-Lam Kwok Computer Science Department, Queens College, CUNY...all past TREC experiments with consistently superior results. Since 1996, we have also participated in the TIPSTER Text Phase 3 program. This...COVERED 00-00-1998 to 00-00-1998 4. TITLE AND SUBTITLE Improving English and Chinese Ad-hoc Retrieval: TIPSTER Text Phase 3 Final Report 5a

  13. Detecting and Jamming Dynamic Communication Networks in Anti-Access Environments

    DTIC Science & Technology

    2011-03-01

    2006. ACM. [30] Chen Wang and Li Xiao. Sensor localization in concave environments. ACM Trans. Sen. Netw., 4(1): 1-31. 2008. [31] Kui Wu, Yong Gao...Chong Liu, Jianping Pan, and Dandan Huang . Robust range-free localization in wireless sensor net- works. Mob. Netw. Appl., 12(5):392-405. 2007. [33...sensor network survey. Comput. Netw., 52(12):2292-2330,2008. [37] Yong Yuan, Zongkai Yang, Min Chen, and Jianhua He. A survey on information

  14. Filtered Mass Density Function for Subgrid Scale Modeling of Turbulent Diffusion Flames

    DTIC Science & Technology

    2005-08-27

    obtain aK(P) e(’Ui) L + a (P) e(Uj) L (Ui)L _0We_ a (a [(KUi)L + a Ktj) L at Oxj axi axj [ xj a i )x I - 2a0 (y Oa(jL) a(p) TL(Ui,Ui) (6a)3 Oxi Oxj Ox...and Frankel, S. H., Two-dimensional large eddy simulation of soot formation in the near-field of a strongly radiating nonpremixed acetylene -air

  15. Optimization of perpendicular anisotropy of Ta-inserted double CoFeB/MgO interface MTJ's for STT-MRAM

    NASA Astrophysics Data System (ADS)

    Clark, Billy D.; Paul, Soumalya; Schwarm, Samuel C.; Singh, Amritpal; Natarajarathinam, Anusha; Gupta, Subhadra

    2016-01-01

    Ta inserts in double magnetic tunnel junctions have been shown to induce perpendicular magnetic anisotropy. We fabricated the central layers of a CoFeB/MgO based double magnetic tunnel junction with a Ta insertion layer between the free layers of the magnetic tunnel junctions. The thickness of the Ta insert and CoFeB layer were varied from 0.5 to 1.1 nm and 0.9 to 1.7 nm respectively, to find which minimum thickness of Ta will induce perpendicular anisotropy in the MTJ. FMR studies were performed to measure the interfacial anisotropy Ku,i. We demonstrated that the most effective stack minimized the CoFeB thickness while maximizing the Ta thickness. This was balanced with the need to keep both CoFeB layers from decoupling or becoming magnetically dead.

  16. Prime Contract Awards of $100,000 or More by Federal Supply Classification or Service Category and Purchasing Office, FY 85. Part 1 (1005-5999).

    DTIC Science & Technology

    1985-01-01

    aKUi ". t (bQ % 04 C3,) 0 <<ZO r-..; 04 c - . 0 ~ ~~~~ z .’. L t m~d.. &Ll 00 0 4 4 4 4 - -~ 4 44 .. 4 (’N . o ~ t 0- ’- l I td CE - Q. W .00 10 4 0...N c’) .0 N .- 4-4 r_ -4-4(0-4 0 N1 Cl) N4 -40 0m U Nr > 0 U) I E E 10 0 .- CE 10*0~ X E 0 1U.0nO g,.9Mqm 0 0-4 .X--4 Xt- o) EUq , 0E. -E. 0.~x-0 04 N

  17. DFT study on the effects of β-cyclodextrin in synthesis of 2-phenylbenzimidazole via benzaldehyde and o-phenylenediamine.

    PubMed

    Cheng, Yamei; Wang, Xueye; Li, Weiwei; Chang, Dan

    2016-12-01

    The conversion of 2-phenylbenzimidazole using o-phenylenediamine and benzaldehyde can be improved significantly under β-cyclodextrin (β-CD). The density functional theory (DFT) method was applied to study the whole process. According to energy parameters (binding energy, deformation energy) and structural deformation, entry models and the reaction process can be pinpointed, with o-phenylenediamine embedding β-CD from a wide rim, and then benzaldehyde passing into the inclusion from the narrow rim. Subsequently, natural bonding orbital (NBO), Mulliken charge, frontier orbital, FuKui function and nuclear magnetic resonance (NMR) methods were employed to reveal the mechanism of electron transfer. The results illustrate that β-CD plays a catalytic role in synthesis reaction mechanism on the secondary side, improving the reactivity and selectivity of the process. Graphical Abstract Density functional theory study of the effects of β-cyclodextrin in synthesis of 2-phenylbenzimidazole via benzaldehyde and o-phenylenediamine.

  18. Total IgE in urban Black South African teenagers: the influence of atopy and helminth infection.

    PubMed

    Levin, M E; Le Souëf, P N; Motala, C

    2008-08-01

    Total IgE levels are usually elevated in allergic diseases, being highest in atopic eczema, followed by atopic asthma and allergic rhinitis. Genetic factors are believed to play a role in total IgE levels, with higher levels seen in Black African subjects. Total IgE is also raised in parasite infection. Thus, the higher total IgE levels in Black Africans could be because of environmental rather than genetic factors. Few studies have investigated the usefulness of total IgE levels in the evaluation of atopy in Black Africans. The objective of this study was to determine the total IgE levels in unselected urban Black African high school children and to correlate this with atopy and ascaris sensitization. Atopic status was assessed by means of specific allergen sensitization (skin prick tests to eight inhalant and four food allergens), self-reported asthma and bronchial hyper-responsiveness measured by methacholine challenge. Ascaris sensitization was assessed by means of ascaris IgE measured by CAP-RAST. Total IgE levels were markedly skewed toward the left and were not distributed in a Gaussian or a log-normal distribution. Skin prick tests were positive for aeroallergens in 32.3% of subjects. Thirty four percent had elevated ascaris IgE. Total IgE was higher in atopic vs. non-atopic subjects and correlated with the number of positive skin prick tests, self-reported asthma and bronchial hyper-responsiveness. Subjects without allergy (or) atopy had a median total IgE of 80-90 kU/I. In addition total IgE correlated with ascaris IgE. Subjects with no ascaris sensitization had median total IgE of 77.1 kU/l. Subjects with neither atopy/asthma nor ascaris sensitisation had a median total IgE of 69.9 kU/I, similar to the levels seen in people of other genetic origins. This study suggests that helminthic infection rather than genetic differences, may be the major determining factor of IgE levels in certain populations.

  19. Chemical profiling approach to evaluate the influence of traditional and simplified decoction methods on the holistic quality of Da-Huang-Xiao-Shi decoction using high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry.

    PubMed

    Yan, Xuemei; Zhang, Qianying; Feng, Fang

    2016-04-01

    Da-Huang-Xiao-Shi decoction, consisting of Rheum officinale Baill, Mirabilitum, Phellodendron amurense Rupr. and Gardenia jasminoides Ellis, is a traditional Chinese medicine used for the treatment of jaundice. As described in "Jin Kui Yao Lue", a traditional multistep decoction of Da-Huang-Xiao-Shi decoction was required while simplified one-step decoction was used in recent repsorts. To investigate the chemical difference between the decoctions obtained by the traditional and simplified preparations, a sensitive and reliable approach of high-performance liquid chromatography coupled with diode-array detection and electrospray ionization time-of-flight mass spectrometry was established. As a result, a total of 105 compounds were detected and identified. Analysis of the chromatogram profiles of the two decoctions showed that many compounds in the decoction of simplified preparation had changed obviously compared with those in traditional preparation. The changes of constituents would be bound to cause the differences in the therapeutic effects of the two decoctions. The present study demonstrated that certain preparation methods significantly affect the holistic quality of traditional Chinese medicines and the use of a suitable preparation method is crucial for these medicines to produce special clinical curative effect. This research results elucidated the scientific basis of traditional preparation methods in Chinese medicines.

  20. A survey of the studies on white tiger shaking head method described by ancient and modern physicians.

    PubMed

    Yue, Gong-lei; Wang, Fu-chun; Bing, Yan; Hong, Jie

    2009-06-01

    Having studied white tiger shaking head method described by ancient and modern physicians, and analyzed and compared its manipulation techniques, the authors believe that the core of white tiger shaking head method originating from Zhenjiu Daquan ([Chinese characters: see text] Complete Book of Acupuncture-Moxibustion) by XU Feng lies in the techniques of "squarely withdrawing and circularly inserting" and "shaking and vibrating", and the manipulation factor is "circularly inserting and shaking, and squarely withdrawing and vibrating". Physicians such as WANG Ji (his second method), YANG Ji-zhou, LU Shou-kang and ZHENG Kui-shan inherited and developed white tiger shaking head method. WANG Ji's first method and what LI Chan and modem physicians YANG Zhao-min and LU Shou-yan described do not belong to white tiger shaking head method. The authors have made a new suggestion on standardizing the manipulation of white tiger shaking head method and approached to new ideas on research into standardization of ancient acupuncture.

  1. [Anaphylactic reaction to Ficus benjamina (weeping fig)].

    PubMed

    Werfel, S; Ruëff, F; Przybilla, B

    2001-10-01

    Ficus benjamina (weeping fig) is a widespread indoor ornamental plant. Allergens of Ficus benjamina are a well-known cause of IgE-mediated respiratory diseases. We treated a 32-year-old female who for 10 years had suffered from perennial rhinoconjunctivitis. When dusting her 2 meter high Ficus benjamina, she developed an anaphylactic reaction which resolved without sequelae. Skin prick testing revealed a strong immediate type reaction to a Ficus extract, the serum concentration of specific IgE-antibodies to Ficus was > 100 kU/I (CAP class 6). In view of these strong test reactions and the conclusive history, no challenge tests with Ficus allergens were performed. After removal of the Ficus plants which she had owned for 17 years and after thorough cleaning of her dwelling, the patient's symptoms of perennial rhinoconjunctivitis stopped. The patient also was sensitized to, but not allergic to natural rubber latex, which occurs frequently in Ficus allergy and probably is due to cross reactivity to allergens from both sources. As Ficus benjamina is an important source of indoor allergens, it should not be used in dwellings or work places.

  2. Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts

    PubMed Central

    Zheng, Luyu; Zhang, Weiyi; Jiang, Miao; Zhang, Huarong; Xiong, Fei; Yu, Yang; Chen, Meijuan; Zhou, Jing; Dai, Xiaoming; Jiang, Ming; Wang, Mingyan; Cheng, Ge; Duan, Jinao; Yu, Wei; Lin, Biaoyang; Fu, Haian; Zhang, Xu

    2013-01-01

    Many traditional Chinese medicine (TCM) formulae have been used in cancer therapy. The JIN formula is an ancient herbal formula recorded in the classic TCM book Jin Kui Yao Lue (Golden Chamber). The JIN formula significantly delayed the growth of subcutaneous human H460 xenografted tumors in vivo compared with the growth of mock controls. Gene array analysis of signal transduction in cancer showed that the JIN formula acted on multiple targets such as the mitogen-activated protein kinase, hedgehog, and Wnt signaling pathways. The coformula treatment of JIN and diamminedichloroplatinum (DDP) affected the stress/heat shock pathway. Proteomic analysis showed 36 and 84 differentially expressed proteins between the mock and DDP groups and between the mock and JIN groups, respectively. GoMiner analysis revealed that the differentially expressed proteins between the JIN and mock groups were enriched during cellular metabolic processes, and so forth. The ones between the DDP and mock groups were enriched during protein-DNA complex assembly, and so forth. Most downregulated proteins in the JIN group were heat shock proteins (HSPs) such as HSP90AA1 and HSPA1B, which could be used as markers to monitor responses to the JIN formula therapy. The mechanism of action of the JIN formula on HSP proteins warrants further investigation. PMID:24066008

  3. Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism

    PubMed Central

    Xiong, Fei; Jiang, Miao; Chen, Meijuan; Wang, Xiaoxia; Zhang, Shiping; Zhou, Jing; Li, Ke; Sheng, Yan; Yin, Lian; Tang, Yuping; Ye, Lihong; Wu, Mianhua; Fu, Haian; Zhang, Xu

    2017-01-01

    MaiMenDong Decoction and WeiJing Decoction (Jin formula) is a traditional Chinese medication that consists of 8 medicinal plants, which recorded in the classical TCM literature Jin Kui Yao Lue and has been utilized in the treatment of lung diseases for hundreds of years in China. The present study aimed to determine the anti-tumor activity and the underlying mechanisms of Jin formula combined with cisplatin in the treatment of non-small cell lung cancer (NSCLC). Xenograft model of NCI-A549 was established in Balb/c nude mice. Five groups, including normal, MOCK, Jin, cisplatin (DDP), and Jin+DDP were included in the study. We found that Jin formula ameliorated the body weight loss caused by DDP 15 days after drug administration. Moreover, the combination of Jin with DDP enhanced the anti-tumor function of DDP. Microarray analysis showed that Jin suppressed gene expression of certain pathways which regulating cell cycle and apoptosis. Furthermore, DDP mainly decreased the gene expression level of angiogenesis associated factors, such as VEGFA, TGF-β and MMP-1. Moreover, co-treatment with Jin and DDP not only down-regulated Bcl-2 and E2F1, but also decreased the expression of MYC, MET, and MCAM. In addition, co-formula decreased the levels of p-AKT (thr308) and p-PTEN, increased Bax/Bcl-2 value, and resulted in apoptosis of tumor cells. Taken together, Jin+DDP significantly inhibited the growth of A549 cell transplanted solid tumor with slight side effect compared to the treatment by DDP only, and had a better effect than the Jin group. The mechanisms may be mainly associated with inactivation of PI3K/AKT pathway and apoptosis induction. PMID:28900482

  4. Blood stasis syndrome in Japan and its molecular biological analysis.

    PubMed

    Goto, Hirozo

    2014-07-01

    Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine, blood is thought of as not only blood but also as a living component of the body. In fact, blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan, the concept of blood stasis syndrome is based on the past literature, for instance, Synopsis of Golden Chamber (Jin Kui Yao Lue), etc. There are many signs of this syndrome, such as a dry mouth, fullness of the abdomen and rough skin. However, the levels of importance of these signs had been unclear. Therefore, in order to determine the levels of seriousness, a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa (Terasawa's Blood Stasis Score). Using the scoring system, we have studied blood stasis syndrome mainly related to blood circulation using modern techniques of analysis. From the results, we found that patients with blood stasis syndrome showed hemorheological abnormalities, and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore, we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis, and found no specific protein expression. However, there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years, as one of the molecular biological factors affecting blood stasis syndrome, we have been studying hypoxia inducible factor, which is located in the upstream of many genes. Above all, blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.

  5. Geography has more influence than language on maternal genetic structure of various northeastern Thai ethnicities.

    PubMed

    Kutanan, Wibhu; Ghirotto, Silvia; Bertorelle, Giorgio; Srithawong, Suparat; Srithongdaeng, Kanokpohn; Pontham, Nattapon; Kangwanpong, Daoroong

    2014-09-01

    Several literatures have shown the influence of geographic and linguistic factors in shaping genetic variation patterns, but their relative impact, if any, in the very heterogeneous northeastern region of Thailand has not yet been studied. This area, called Isan, is geographically structured in two wide basins, the Sakon Nakorn Basin and the Korat Basin, serving today as home to diverse ethnicities encompassing two different linguistic families, that is, the Austro-Asiatic; Suay (Kui), Mon, Chaobon (Nyahkur), So and Khmer, and the Tai-Kadai; Saek, Nyaw, Phu Tai, Kaleung and Lao Isan. In this study, we evaluated the relative role of geographic distance and barriers as well as linguistic differences as possible causes affecting the maternal genetic distances among northeastern Thai ethnicities. A 596-bp segment of the hypervariable region I mitochondrial DNA was utilized to elucidate the genetic structure and biological affinity from 433 individuals. Different statistical analyses agreed in suggesting that most ethnic groups in the Sakon Nakorn Basin are closely related. Mantel test revealed that genetic distances were highly associated to geographic (r = 0.445, P<0.01) but not to linguistic (r = 0.001, P>0.01) distances. Three evolutionary models were compared by Approximate Bayesian Computation. The posterior probability of the scenario, which assumed an initial population divergence possibly related to reduced gene flow among basins, was equal or higher than 0.87. All analyses exhibited concordant results supporting that geography was the most relevant factor in determining the maternal genetic structure of northeastern Thai populations.

  6. Cosmic-ray exposure ages of chondrules

    NASA Astrophysics Data System (ADS)

    Roth, Antoine S. G.; Metzler, Knut; Baumgartner, Lukas P.; Leya, Ingo

    2016-07-01

    If chondrules were exposed to cosmic rays prior to meteorite compaction, they should retain an excess of cosmogenic noble gases. Beyersdorf-Kuis et al. (2015) showed that such excesses can be detected provided that the chemical composition of each individual chondrule is precisely known. However, their study was limited to a few samples as they had to be irradiated in a nuclear reactor for instrumental neutron activation analysis. We developed a novel analytical protocol that combines the measurements of He and Ne isotopic concentrations with a fast method to correct for differences in chemical composition using micro X-ray computed tomography. Our main idea is to combine noble gas, nuclear track, and petrography data for numerous chondrules to understand the precompaction exposure history of the chondrite parent bodies. Here, we report our results for a total of 77 chondrules and four matrix samples from NWA 8276 (L3.00), NWA 8007 (L3.2), and Bjurböle (L/LL4). All chondrules from the same meteorite have within uncertainty identical 21Ne exposure ages, and all chondrules from Bjurböle have within uncertainty identical 3He exposure ages. However, most chondrules from NWA 8276 and a few from NWA 8007 show small but resolvable differences in 3He exposure age that we attribute to matrix contamination and/or gas loss. The finding that none of the chondrules has noble gas excesses is consistent with the uniform track density found for each meteorite. We conclude that the studied chondrules did not experience a precompaction exposure longer than a few Ma assuming present-day flux of galactic cosmic rays. A majority of chondrules from L and LL chondrites thus rapidly accreted and/or was efficiently shielded from cosmic rays in the solar nebula.

  7. Spontaneous emission in dielectric nanoparticles

    NASA Astrophysics Data System (ADS)

    Pukhov, K. K.; Basiev, T. T.; Orlovskii, Yu. V.

    2008-09-01

    An analytical expression is obtained for the radiative-decay rate of an excited optical center in an ellipsoidal dielectric nanoparticle (with sizes much less than the wavelength) surrounded by a dielectric medium. It is found that the ratio of the decay rate A nano of an excited optical center in the nanoparticle to the decay rate A bulk of an excited optical center in the bulk sample is independent of the local-field correction and, therefore, of the adopted local-field model. Moreover, the expression implies that the ratio A nano/ A bulk for oblate and prolate ellipsoids depends strongly on the orientation of the dipole moment of the transition with respect to the ellipsoid axes. In the case of spherical nanoparticles, a formula relating the decay rate A nano and the dielectric parameters of the nanocomposite and the volumetric content c of these particles in the nanocomposite is derived. This formula reduces to a known expression for spherical nanoparticles in the limit c ≪ 1, while the ratio A nano/ A bulk approaches unity as c tends to unity. The analysis shows that the approach used in a number of papers {H. P. Christensen, D. R. Gabbe, and H. P. Jenssen, Phys. Rev. B 25, 1467 (1982); R. S. Meltzer, S. P. Feofilov, B. Tissue, and H. B. Yuan, Phys. Rev. B 60, R14012 (1999); R. I. Zakharchenya, A. A. Kaplyanskii, A. B. Kulinkin, et al., Fiz. Tverd. Tela 45, 2104 (2003) [Phys. Solid State 45, 2209 (2003)]; G. Manoj Kumar, D. Narayana Rao, and G. S. Agarwal, Phys. Rev. Lett. 91, 203903 (2003); Chang-Kui Duan, Michael F. Reid, and Zhongqing Wang, Phys. Lett. A 343, 474 (2005); K. Dolgaleva, R. W. Boyd, and P. W. Milonni, J. Opt. Soc. Am. B 24, 516 (2007)}, for which the formula for A nano is derived merely by substituting the bulk refractive index by the effective refractive index of the nanocomposite must be revised, because the resulting ratio A nano/ A bulk turns out to depend on the local-field model. The formulas for the emission and absorption cross

  8. Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition

    PubMed Central

    Nieters, Alexandra; Łuczyńska, Anna; Becker, Susen; Becker, Nikolaus; Vermeulen, Roel; Overvad, Kim; Aleksandrova, Krasimira; Boeing, Heiner; Lagiou, Pagona; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Krogh, Vittorio; Masala, Giovanna; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas.; Jeurnink, Suzanne M.; Weiderpass, Elisabete; Ardanaz, Eva; Chirlaque, Maria-Dolores; Sánchez, María-José; Sánchez, Soledad; Borgquist, Signe; Butt, Salma; Melin, Beatrice; Späth, Florentin; Rinaldi, Sabina; Brennan, Paul; Kelly, Rachel S.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolf

    2014-01-01

    Previous epidemiological studies suggest an inverse association between allergies, marked by elevated immunoglobulin (Ig) E levels, and non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent and prospective data are sparse. We examined the association between prediagnostic total (low: <20; intermediate: 20–100; high >100 kU/l) and specific IgE (negative: <0.35; positive ≥0.35 kU/I) concentrations against inhalant antigens and lymphoma risk in a study nested within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 1021 incident cases and matched controls of NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up time of 7 years were investigated. Multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CI) were calculated by conditional logistic regression. Specific IgE was not associated with the risk of MM, B-cell NHL and B-cell NHL subtypes. In contrast, total IgE levels were inversely associated with the risk of MM [high level: OR = 0.40 (95% CI = 0.21–0.79)] and B-cell NHL [intermediate level: OR = 0.68 (95% CI = 0.53–0.88); high level: OR = 0.62 (95% CI = 0.44–0.86)], largely on the basis of a strong inverse association with chronic lymphocytic leukemia [CLL; intermediate level: OR = 0.49 (95% CI = 0.30–0.80); high level: OR = 0.13 (95% CI = 0.05–0.35)] risk. The inverse relationship for CLL remained significant for those diagnosed 5 years after baseline. The findings of this large prospective study demonstrated significantly lower prediagnostic total IgE levels among CLL and MM cases compared with matched controls. This corresponds to the clinical immunodeficiency state often observed in CLL patients prior to diagnosis. No support for an inverse association between prediagnostic levels of specific IgE and NHL risk was found. PMID:25269801

  9. Air quality in the mountain climate-balneological resort Kislovodsk

    NASA Astrophysics Data System (ADS)

    Chalaya, Elena; Efimenko, Natalia; Povolotckaia, Nina; Senik, Irina; Slepykh, Victor

    2016-04-01

    There has been studied the quality of the surface atmosphere in the mountain climate-balneological resort Kislovodsk (MCBRK) to treat by means of climate and landscape (TCL) of the patients suffering from bronchial asthma (PBA) [1]. 60 children (31 boys and 29 girls at the age of 9-11 years) were examined in the course of 34 days of the resort treatment in MCBRK, PBA (ICD-10 G45,0) in a remission stage. There have been used the data of the long-term bioclimatic monitoring (BCM) that is carried out by PRIC FMBA, aerosol monitoring of IFA RAS, landscape monitoring of SNP in Kislovodsk Resort Park (KRP) as well as the data of medical monitoring, daily testing of meteopathic reactions (MPR), indicators dynamics of bronchial patency, cardiac rhythm, neurovascular reactivity, psychoemotional status of patients. TCL was carried out in the form of walks under the canopy of Betula pendula Roth., Salix f. pendula, acer platanoides globosum, Aesculus hippocastanum L., Phellodendron amurense, Tilia caucasica in KRP daily lasting from 1 till 2 hours. The results of a complex research showed that at TCL in KRP the favourable heat balance had 92% warm relations (TB<600BT/m2 - comfort and weak over comfort); the increased natural aero ionization (∑(N+)+(N-)=1350-1850 ion/cm3 at KUI<0,88); bacteriostatics natural trees 13-58%; the level of the weighed aerosol particles (the size of 500-20000 nanometers) from 1,2 to 3,6 particles/cm3 - (from pure to poorly polluted atmosphere); only 86% of the patients had cases with the increased and high transparency of the atmosphere (0,756-0,849). Under the influence of the course TCL 53(88%) patients had improved indicators of bronchial patency, 58(97%) had signs of increasing qualities of regulatory processes in the organism (vegetative regulation for 14%; neurohumoral regulation for 12%; psychoemotional regulation for 16%; the ability of the organism to adaptation for 17%); 38(63%) patients had vegetative index of Kerde that reached normal

  10. Environmental problems of resort towns of Caucasian Mineralnye Vody region during the anthropocene era

    NASA Astrophysics Data System (ADS)

    Efimenko, Natalia; Chalaya, Elena; Povolotckaia, Nina; Artamonova, Mariya; Senik, Irina; Slepykh, Viktor

    2017-04-01

    There has been studied the influence of ecological factors on rehabilitation properties of the atmospheric surface layer (ASL) in the mountain resorts of the Caucasian Mineralnye Vody Region (CMVR) according to the research methods [1] accepted in balneology. Taking into consideration the data of the long-term complex multiple-factor bioclimatic monitoring (PRIC FMBA, IFA RAS, SNP), it has been revealed: - the increase in frequency of inter-day variability of the integral index of weather pathogenicity (IIWP) in the range of 0,35KUI >2,0). These signs are noted on the background of the continuing period of climate warming. At the present time the rehabilitation potential of ASL in the resorts of Caucasian Mineralnye Vody region is estimated within 2,08-2,68 points (max =3,0 points). Mountainous areas are more sensitive to anthropogenic impacts, changes of radiation mode and circulation modes. It was revealed that

  11. Specific weather biotrop factors in the mountain resorts of North Caucasus

    NASA Astrophysics Data System (ADS)

    Efimenko, Natalia; Chalaya, Elena; Povolotckaia, Nina; Senik, Irina; Slepykh, Victor

    2015-04-01

    Key aspects of weather therapeutic action in the mountain resorts of the Northern Caucasus (RNC) are formed under the combined influence of global, regional and local atmospheric processes, picturesque landscape, vegetation which create specificity and attraction of the weather regime for the interests of resort rehabilitation, recreation and tourism practically during the whole year. They include high purity of surface atmosphere (background level of aerosols for the countryside, the transparency of the atmosphere 0.780 -0.890); natural hypo barium and hypoxia (5-10%); increased natural aeroionization (N+=400-1000 ion/cm3; N- = 600-1200 ion/cm3; KUI = 0.8 -1.0); the softness of temperature rate (± 600 W/m ); regime of solar radiation favourable for heliotherapy. Pathogenic effects in the mountains can occur both in front atmospheric processes and in conditions of relatively favorable weather. For example, in a stable anti-cyclonic air mass with the sunny weather, foehn effects can happen that are accompanied by excessively low air humidity (lower than 20-30%), the air temperature rises in the afternoon (in winter until 15- 20°C, in summer - up to 25-35°C). The situation can be worsened by ozone intrusion (O3) with the increase of its concentration by 20 ppb or more, temperature stratification change, formation of pollution accumulation conditions in the gorges and valleys where the resort towns are located. We can observe: the increase in the concentration of aerosol pollution from 1.78 to 4 and even up to 8-10 particles/cm (particle diameter is 500-1000 nm); the rise in mass concentration of submicron aerosol up to 75 mkg/m3 and the gas pollution (CO, COx, O3) of the surface atmosphere. Against this backdrop the effects of rapid changes in the chemical composition of natural ions due to the formation of positive nitrogen ions (often with a prevalence of positive over negative air ions) can be sometimes developed. In such situations people suffering from

  12. Modelling the interaction between volcanic sources and fault zones at the Etna Mount

    NASA Astrophysics Data System (ADS)

    Aloisi, Marco; Mattia, Mario; Monaco, Carmelo; Pulvirenti, Fabio

    2010-05-01

    account the presence of the main "crust discontinuities", either in the "no friction" or in the "Coulomb friction" cases, inside a medium not-homogeneous, with topography and gravitational loading. Solving the contact problems for the Pernicana, Timpe, Trecastagni, Acitrezza and S. Venerina fault systems, we investigate the variations in the deformation pattern and in the static stress change with respect to the homogeneous elastic half-space modelling case. Moreover, we quantify if the intrusive process encouraged the seismogenic structures to slip, producing the 29 October 2002 earthquake. References: Aloisi, M., A. Bonaccorso, S. Gambino, M. Mattia, and G. Puglisi (2003), Etna 2002 eruption imaged from continuous tilt and GPS data, Geophys. Res. Lett., 30(23), 2214, doi:10.1029/2003GL018896. Aloisi, M., A. Bonaccorso, and S. Gambino (2006), Imaging composite dike propagation (Etna, 2002 case), J. Geophys. Res., 111, B06404, doi:10.1029/2005JB003908. Bonforte A., Carbone D., Greco F. and M. Palano (2007), Intrusive mechanism of the 2002 NE-rift eruption at Mt Etna (Italy)modelled using GPS and gravity data, Geophys. J. Int. (2007) 169, 339-347 doi: 10.1111/j.1365-246X.2006.03249.x. Currenti G., Piombo A., Del Negro C. and M. Dragoni (2008a), Piezomagnetic fields due to an inclined rectangular fault in a viscoelastic half-space: an application to the 2002-2003 Etna eruption, Geophys. J. Int., 175, 901-912 doi: 10.1111/j.1365-246X.2008.03941.x. Currenti, G., C. Del Negro, G. Ganci, and C. A. Williams (2008b), Static stress changes induced by the magmatic intrusions during the 2002-2003 Etna eruption, J. Geophys. Res., 113, B10206, doi:10.1029/2007JB005301. Liu J. and Li Zhong Kui (2007), The Deformation of Discontinuity in the DDA Method, Key Engineering Materials, Volume "Progresses in Fracture and Strength of Materials and Structures", Vol. 353 - 358, Pag. 3047 - 3050, DOI: 10.4028/www.scientific.net/KEM.353-358.3047 Walter, T. R., V. Acocella, M. Neri, and F. Amelung