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  1. Obituary: Roland Svensson, 1950-2003

    NASA Astrophysics Data System (ADS)

    Björnsson, Claes-Ingvar

    2003-12-01

    Roland Svensson was found dead on 8 April 2003. He succumbed to the complications arising from diabetes. His contribution to the understanding of the basic properties of relativistic plasmas remains a cornerstone when studying radiation processes in many astrophysical contexts. Roland was born on 6 May 1950 in Karlshamn, Sweden. At a young age he moved with his family to Skåne, the southernmost part of Sweden. This is where he received his early education including a BS in Physics at the University of Lund in 1973. For the rest of his life, this region was home for Roland. His mother and father are Linnea Martinsson (d. 1984) and Sune Svensson. The two younger brothers are Lennart and Peter. Lennart works as a machine engineer in Sweden while Peter has settled in California as a biology professor. Roland started graduate studies in theoretical physics in Lund before receiving a Fulbright Scholarship in 1976. He then moved to the University of California in Santa Cruz and enrolled in the astronomy and astrophysics graduate program. Although his interest in astronomy had been raised during the time in Lund, it was the stimulating environment in Santa Cruz that convinced Roland to concentrate on research in astronomy. With Roland's attitude of never accepting anything unless he understood its roots, his extended background in physics served him well throughout his astronomy career; in particular, it influenced his choice of a thesis topic. At the time, the importance of relativistic temperatures attained by accreting matter in the immediate vicinity of neutron stars and black holes was becoming clear. Roland set out to make a detailed description of the physical effects electron-positron pair production and annihilation would have on such plasmas. In 1981 Roland defended his thesis titled ``Physical Properties in Relativistic Plasmas" and completed his PhD under the supervision of Bill Mathews. Roland extended the results of his thesis during two post-docs, first at

  2. Academic Performance in Children with Rolandic Epilepsy

    ERIC Educational Resources Information Center

    Piccinelli, P.; Borgatti, R.; Aldini, A.; Bindelli, D.; Ferri, M.; Perna, S.; Pitillo, G.; Termine, C.; Zambonin, F.; Balottin, U.

    2008-01-01

    The aim of this study was to investigate the frequency of reading, writing, and calculation disabilities in children with typical rolandic epilepsy (RE) and healthy control children. We also aimed to define the possible electroclinical markers of specific cognitive dysfunctions in RE. School abilities were evaluated and compared in 20 children…

  3. DETAIL OF PLAQUE DESCRIBING LION SCULPTURES BY ROLAND HINTON PERRY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF PLAQUE DESCRIBING LION SCULPTURES BY ROLAND HINTON PERRY, NORTHWEST ABUTMENT - Connecticut Avenue Bridge, Spans Rock Creek & Potomac Parkway at Connecticut Avenue, Washington, District of Columbia, DC

  4. Sleep and behavioral problems in rolandic epilepsy.

    PubMed

    Samaitienė, Rūta; Norkūnienė, Jolita; Tumienė, Birutė; Grikinienė, Jurgita

    2013-02-01

    Although patients with benign childhood epilepsy with centrotemporal spikes exhibit a benign course of the disease, some of them display sleep and behavioral problems. Sixty-one patients with rolandic epilepsy, aged 6-11 years, were included in this study. The patients were divided into two subgroups according to the presence of seizures over the preceding 6 months. The control group comprised 25 patients without epilepsy and with similar characteristics in terms of age and sex. All patients underwent evaluation of sleep (Sleep Disturbance Scale for Children) and behavior (Lithuanian version of the Child Behaviour Checklist). Only patients who had had seizures over the preceding 6 months displayed significantly higher scores for sleep problems (disorders of excessive daytime sleepiness, disorders of sleep-wake transition, and scores for total sleep problems), worse sleep quality (longer sleep-onset latency), and behavioral problems (anxiety/depression, social problems, thought problems, attention problems, and aggressive behavior) than the patients of the control group. Our data add to evidence that active epilepsy has an impact on sleep and behavior. Clinically significant sleep problems were related to the higher risk of behavioral problems. Parents' ratings for existing sleep problems were sensitive to Sleep Disturbance Scale for Children scores above normal values.

  5. A Neurocognitive Endophenotype Associated with Rolandic Epilepsy

    PubMed Central

    Smith, Anna B; Kavros, Peregrine M; Clarke, Tara; Dorta, Nelson J; Tremont, Geoffrey; Pal, Deb K

    2011-01-01

    Purpose Children with Rolandic Epilepsy (RE) experience difficulties in reading, language and attention. Their siblings are at high risk of dyslexia but are not otherwise known to have neurocognitive deficits. We therefore sought evidence for a RE-associated neurocognitive endophenotype. Methods Thirteen probands (male:female 9:4) and 11 epilepsy-free siblings (male:female 5:6) completed a neurocognitive evaluation within the domains of reading, language and attention. Frequencies of impairment were compared, and mean standardized scores of children with RE and their siblings were each compared against population means. Key findings Frequency of impairment in each domain was comparable for siblings and probands: 9% of siblings and 31% of probands were reading impaired; 36% of siblings and 54% of probands were language impaired; 70% of siblings and 67% of probands had attention impairments. Comparison of differences between sample and population means revealed evidence of a similar pattern of language deficits in both groups, specifically for picture naming and attention to competing words. For measures of attention, both groups made significantly higher omission errors and were impaired in their ability to sustain attention. Significance Children with RE and unaffected siblings demonstrate neurocognitive impairments in the domains of language and attention that are likely to remain undetected with general clinical protocols. Neurocognitively impaired probands and siblings showed a remarkably similar profile of deficits in language and attention that could explain poor academic performance. Early evaluation and intervention may benefit these children academically. PMID:22220688

  6. Roland Barthes and Decomposing/Deterritorializing the Writing Classroom.

    ERIC Educational Resources Information Center

    Richmond, Joan L.

    Roland Barthes points out in his pedagogical essays that, although students have been filled with horror stories of professorial expectations, at the same time they have expectations of their own. Barthes' points should be considered as a way of examining the classroom space and common writing teaching practices and opening them up to different…

  7. Superculture? Thoughts Prompted by Roland S. Persson's Essay

    ERIC Educational Resources Information Center

    Tebbs, Trevor J.

    2012-01-01

    The author finds Roland S. Persson's (2012a) paper to be timely, fascinating, important and powerful. At risk of mixing metaphors, it provides much food for thought and a penetrating lens through which all those vested in the optimal realisation of human potential would be prudent to review their own perceptions, boundaries of belief and…

  8. The Clinical Implications of Todd Paralysis in Children With Benign Rolandic Epilepsy.

    PubMed

    Dai, Alper I; Demiryürek, Seniz

    2016-03-01

    The aim of this study was to describe the clinical and electroencephalographic (EEG) findings of postictal Todd paralysis in benign rolandic epilepsy of childhood and find out the possible correlation with migraine. Based on International Headache Society pediatric migraine criteria, patients were investigated for migraine, and 12 of the 108 patients with benign rolandic epilepsy (6 girls and 6 boys, 11.1%) were found to have postictal Todd paralysis. Ten of these 12 patients (83.3%) had pediatric migraine based on the diagnostic criteria. We showed comorbidity of migraine and benign rolandic epilepsy with postictal Todd paralysis in children. Increased incidence of migraine in the present study suggest that children who have benign rolandic epilepsy and postictal Todd paralysis are more likely to have migraines.

  9. Risk factors for reading disability in rolandic epilepsy families

    PubMed Central

    Vega, Yaiza Hernández; Smith, Anna; Cockerill, Hannah; Tang, Shan; Agirre-Arrizubieta, Zaloa; Goyal, Sushma; Pina, Marisa; Akman, Cigdem I; Jolleff, Nicola; McGinnity, Colm; Gomez, Kumudini; Gupta, Rajesh; Hughes, Elaine; Jackman, John; McCormick, David; Oren, Caroline; Scott, David; Taylor, Jacqueline; Trounce, John; Clarke, Tara; Kugler, Steven; Mandelbaum, David E; McGoldrick, Patricia; Wolf, Steven; Strug, Lisa J; Pal, Deb K

    2015-01-01

    OBJECTIVE The high prevalence and impact of neurodevelopmental comorbidities in childhood epilepsy are now well known, as are the increased risks and familial aggregation of reading disability (RD) and speech sound disorder (SSD) in rolandic epilepsy (RE). The risk factors for RD in the general population include male sex, SSD and ADHD but it is not known if these are the same in RE or whether there is a contributory role of seizure and treatment related variables. METHODS An observational study of 108 RE probands (age range 3.6–22 years) and their 159 siblings (age range 1–29 years; 83 with EEG data) singly ascertained in the US or UK through an affected RE proband. We used a nested case-control design, multiple logistic regression and generalized estimating equations to test the hypothesis of association between RD and seizure variables or antiepileptic drug treatment in RE; we also assessed an association between EEG focal sharp waves and RD in siblings. RESULTS RD was reported in 42% of probands and 22% of siblings. Among probands, RD was strongly associated with a history of SSD (OR 9.64, 95% CI: 2.45–37.21), ADHD symptoms (OR 10.31, 95% CI: 2.15–49.44), and male sex (OR 3.62, 95% CI: 1.11–11.75), but not with seizure or treatment variables. Among siblings, RD was independently associated only with SSD (OR 4.30, 95%CI: 1.42–13.0) and not with the presence of interictal EEG focal sharp waves. SIGNIFICANCE The principal risk factors for RD in RE are SSD, ADHD and male sex, the same risk factors as for RD without epilepsy. Seizure or treatment variables do not appear to be important risk factors for RD in RE probands, and there was no evidence to support interictal EEG focal sharp waves as a risk factor for RD in siblings. Future studies should focus on the precise neuropsychological characterisation of RD in RE families, and on the effectiveness of standard oral-language and reading interventions. PMID:26580214

  10. "Profound Levels of Learning" through Brain-Based Teaching: A Tribute to Roland Barth

    ERIC Educational Resources Information Center

    Shore, Rebecca Ann

    2012-01-01

    This article is a tribute to the writings of Dr. Roland Barth through a personal story spanning over two decades. It explores Dr. Barth's personal vision of an effective school through recent brain-based principles. It revisits Barth's axioms and uses recent implications from the neurosciences as new supporting evidence for their success in…

  11. Reduced Structural Connectivity between Sensorimotor and Language Areas in Rolandic Epilepsy

    PubMed Central

    Besseling, René M. H.; Jansen, Jacobus F. A.; Overvliet, Geke M.; van der Kruijs, Sylvie J. M.; Ebus, Saskia C. M.; de Louw, Anton; Hofman, Paul A. M.; Vles, Johannes S. H.; Aldenkamp, Albert P.; Backes, Walter H.

    2013-01-01

    Introduction Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. Methods Twenty-three children with RE and 23 matched controls (age: 8–14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm2, 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. Results Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). Conclusion In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca’s area) and the supramarginal gyrus (Wernicke’s area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE. PMID:24376719

  12. Bilateral Rolandic Operculum processing underlying heartbeat awareness reflects changes in bodily self-consciousness.

    PubMed

    Blefari, Maria Laura; Martuzzi, Roberto; Salomon, Roy; Bello-Ruiz, Javier; Herbelin, Bruno; Serino, Andrea; Blanke, Olaf

    2017-03-30

    Exteroceptive bodily signals (including tactile, proprioceptive, and visual signals) are important information contributing to self-consciousness. Moreover, prominent theories proposed that visceral signals about internal bodily states are equally or even more important. Neuroimaging studies have described several brain regions which process signals related to bodily self-consciousness (BSC) based on the integration of exteroceptive signals (e.g. the premotor cortex, the angular gyrus, the supramarginal gyrus and the extrastriate body area), and that another brain region, the insula/operculum which is involved in interoception and interoceptive awareness, processes signals critical for self-awareness. Providing evidence for the integration of exteroceptive and interoceptive bodily signals, recent behavioral experiments have demonstrated that the manipulation of interoceptive (i.e. cardiac) signals, coupled with that of exteroceptive (i.e. visual) signals, also modulates BSC. Does this integration occur within or outside the structures described above? To this end, we adapted a recently designed protocol that uses cardio-visual stimulation to induce altered states of BSC to fMRI. Additionally, we measured neural activity in a classical interoceptive task. We found six brain regions (the bilateral Rolandic operculum, the bilateral supramarginal gyrus, the right frontal inferior operculum, and the left temporal superior gyrus) that were activated differently during the interoception task as opposed to a control task. The brain regions which showed the highest selectivity for BSC based on our cardio-visual manipulation were found in the bilateral Rolandic operculum. Given our findings, we propose that the Rolandic operculum processes integrated exteroceptive-interoceptive signals that are necessary for interoceptive awareness as well as BSC. This article is protected by copyright. All rights reserved.

  13. [In memory of Roland Kuhn (1912-2005) and 50 years of imipramine].

    PubMed

    Bossong, F

    2008-09-01

    Based on his clinical experience and knowledge in the humanities, phenomenology, and natural sciences, the Swiss psychiatrist and Rorschach expert Roland Kuhn discovered the specific antidepressant effect of imipramine in the treatment of vital depressive disorder. This discovery of the first tricyclic antidepressant drug shows how an education covering the various fields of psychiatry facilitates therapeutic and scientific achievements. Kuhn's methods as a psychiatrist and his papers can show present and future generations of psychiatrist ways to make new discoveries in the field of psychiatry, psychotherapy, and psychopharmacology.

  14. Rolandic beta-band activity correlates with decision time to move.

    PubMed

    Jo, Han-Gue; Hinterberger, Thilo; Wittmann, Marc; Schmidt, Stefan

    2016-03-11

    Research findings link rolandic beta-band activity to voluntary movements, but a linkage with the decision time to move remains unknown. We found that beta-band (16-28Hz) activity shortly before the movement onset is relevant for the decision time to move: the more pronounced the decrease in beta-band synchronization, the earlier the subjective experience of the decision to move. The linkage was relevant regarding 'decision', but not regarding 'intention' timing that has been often applied in the study of free will. Our findings suggest that oscillatory neural activity in the beta-band is an important neural signature pertaining to the subjective experience of making a decision to move.

  15. [Cortical mapping and neurophysiological monitoring during resection of an arteriovenous malformation in the rolandic region].

    PubMed

    Vega-Zelaya, Lorena; Pedrosa-Sánchez, Manuel; Pastor, Jesús

    2014-07-01

    INTRODUCTION. Surgery of arteriovenous malformations of eloquent areas has a significant risk of causing severe neurological deficits. CASE REPORT. A 39 years old woman having a headache, showed an arteriovenous malformation in right rolandic region. During resection, performed under general anesthesia, a neurophysiological mapping and subsequently intraoperative neurophysiological monitoring of motor and somatosensory functions was performed. The temporary closure of an artery resulted in a severe motor impairment, reversible after remove the clipping, so that artery had to be respected during the intervention. After resection, the motor and sensory responses were normal. The patient was discharged without any neurological deficits. CONCLUSION. Functional mapping and intraoperative neurophysiological monitoring were very helpful for the identification and protection of eloquent areas. The use of these techniques for resection of arteriovenous malformations located in functionally relevant areas, allows a safely surgery in patients under general anesthesia.

  16. Modulation of Rolandic Beta-Band Oscillations during Motor Simulation of Joint Actions.

    PubMed

    Ménoret, Mathilde; Bourguignon, Mathieu; Hari, Riitta

    2015-01-01

    Successful joint actions require precise temporal and spatial coordination between individuals who aim to achieve a common goal. A growing number of behavioral data suggest that to efficiently couple and coordinate a joint task, the actors have to represent both own and the partner's actions. However it is unclear how the motor system is specifically recruited for joint actions. To find out how the goal and the presence of the partner's hand can impact the motor activity during joint action, we assessed the functional state of 16 participants' motor cortex during observation and associated motor imagery of joint actions, individual actions, and non-goal-directed actions performed with either 1 or 2 hands. As an indicator of the functional state of the motor cortex, we used the reactivity of the rolandic magnetoencephalographic (MEG) beta rhythm following median-nerve stimulation. Motor imagery combined with action observation was associated with activation of the observer's motor cortex, mainly in the hemisphere contralateral to the viewed (and at the same time imagined) hand actions. The motor-cortex involvement was enhanced when the goal of the actions was visible but also, in the ipsilateral hemisphere, when the partner's hand was visible in the display. During joint action, the partner's action, in addition to the participant's own action, thus seems to be represented in the motor cortex so that it can be triggered by the mere presence of an acting hand in the peripersonal space.

  17. Modulation of Rolandic Beta-Band Oscillations during Motor Simulation of Joint Actions

    PubMed Central

    Ménoret, Mathilde; Bourguignon, Mathieu; Hari, Riitta

    2015-01-01

    Successful joint actions require precise temporal and spatial coordination between individuals who aim to achieve a common goal. A growing number of behavioral data suggest that to efficiently couple and coordinate a joint task, the actors have to represent both own and the partner’s actions. However it is unclear how the motor system is specifically recruited for joint actions. To find out how the goal and the presence of the partner’s hand can impact the motor activity during joint action, we assessed the functional state of 16 participants’ motor cortex during observation and associated motor imagery of joint actions, individual actions, and non-goal-directed actions performed with either 1 or 2 hands. As an indicator of the functional state of the motor cortex, we used the reactivity of the rolandic magnetoencephalographic (MEG) beta rhythm following median-nerve stimulation. Motor imagery combined with action observation was associated with activation of the observer’s motor cortex, mainly in the hemisphere contralateral to the viewed (and at the same time imagined) hand actions. The motor-cortex involvement was enhanced when the goal of the actions was visible but also, in the ipsilateral hemisphere, when the partner’s hand was visible in the display. During joint action, the partner’s action, in addition to the participant’s own action, thus seems to be represented in the motor cortex so that it can be triggered by the mere presence of an acting hand in the peripersonal space. PMID:26151634

  18. Are dyslexia and dyscalculia associated with Rolandic epilepsy? A short report on ten Italian patients.

    PubMed

    Canavese, Carlotta; Rigardetto, Roberto; Viano, Vilma; Vittorini, Roberta; Bassi, Bianca; Pieri, Ilaria; Capizzi, Giorgio

    2007-12-01

    Rolandic epilepsy (RE) is the most common childhood epilepsy syndrome with a good, long-term outcome. Nevertheless, some studies indicate that children with RE have more scholastic and neuropsychological problems than controls. The purpose of this study was to describe neuropsychological findings in a small group of Italian children with RE, focusing on dyslexia and dyscalculia. Possible correlations between these findings and the age-at-onset of seizures, duration of active epilepsy, frequency, type and localization of epileptic discharges were examined. Children affected by RE, aged nine to eleven years were selected from patients admitted to the outpatient service of our Clinic. They underwent cognitive evaluation, specific evaluation for dyslexia and dyscalculia, and awake and sleep EEG recordings. We found two patients out of the ten with dyscalculia, one of whom also had characteristics of dyslexia. This small study suggests that dyscalculia and dyslexia might be more frequent than expected in children with RE. No significant correlations between this finding and EEG, seizure-frequency or age-at-onset of epilepsy were found in our patients.

  19. Psychiatric and Neurocognitive Evaluation Focused on Frontal Lobe Functions in Rolandic Epilepsy

    PubMed Central

    AYAZ, Muhammed; KARAKAYA, Işık; AYAZ, Ayşe Burcu; KARA, Bülent; KUTLU, Mahire

    2013-01-01

    Introduction In this study, we aimed to assess the behavioral problems, psychiatric disorders and neurocognitive functions focusing on frontal lobe functions in children with rolandic epilepsy (RE) and compare them with a control group. Method 31 children with RE, aged between 8 and 13,5 years were compared with a control group matched for age, sex and socioeconomic status. Behavioral problems were assessed by the Child Behavior Checklist (CBCL) and psychiatric diagnoses were established by using the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version. The Wechsler Intelligence Scale for Children-Revised (WISC-R), Wisconsin Card Sorting Test (WCST) and the Stroop Color and Word Test (SCWT) were applied in both groups of children. Result The RE group presented more psychiatric disorders than the control group. Verbal and total IQ scores in the RE group were lower than in the control group. Although the groups did not differ from each other in WCST scores, children with RE displayed lower performance in SCWT. The RE group had a higher externalizing score and higher total scores in CBCL. Conclusion It was concluded that RE did not affect basic frontal lobe functions significantly, had negative effects on attention and IQ performance and increased behavioral problems and psychiatric disorders.

  20. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility

    PubMed Central

    Mellish, Louise C; Dunkley, Colin; Ferrie, Colin D; Pal, Deb K

    2015-01-01

    Background The evidence base for management of childhood epilepsy is poor, especially for the most common specific syndromes such as rolandic epilepsy (RE) and Panayiotopoulos syndrome (PS). Considerable international variation in management and controversy about non-treatment indicate the need for high quality randomised controlled trials (RCT). The aim of this study is, therefore, to describe current UK practice and explore the feasibility of different RCT designs for RE and PS. Methods We conducted an online survey of 590 UK paediatricians who treat epilepsy. Thirty-two questions covered annual caseload, investigation and management practice, factors influencing treatment, antiepileptic drug preferences and hypothetical trial design preferences. Results 132 responded (22%): 81% were paediatricians and 95% at consultant seniority. We estimated, annually, 751 new RE cases and 233 PS cases. Electroencephalography (EEG) is requested at least half the time in approximately 70% of cases; MRI brain at least half the time in 40%–65% cases and neuropsychological evaluation in 7%–8%. Clinicians reported non-treatment in 40%: main reasons were low frequency of seizures and parent/child preferences. Carbamazepine is the preferred older, and levetiracetam the preferred newer, RCT arm. Approximately one-half considered active and placebo designs acceptable, choosing seizures as primary and cognitive/behavioural measures as secondary outcomes. Conclusions Management among respondents is broadly in line with national guidance, although with possible overuse of brain imaging and underuse of EEG and neuropsychological assessments. A large proportion of patients in the UK remains untreated, and clinicians seem amenable to a range of RCT designs, with carbamazepine and levetiracetam the preferred active drugs. PMID:25202134

  1. Delayed convergence between brain network structure and function in rolandic epilepsy

    PubMed Central

    Besseling, René M. H.; Jansen, Jacobus F. A.; Overvliet, Geke M.; van der Kruijs, Sylvie J. M.; Ebus, Saskia C. M.; de Louw, Anton J. A.; Hofman, Paul A. M.; Aldenkamp, Albert P.; Backes, Walter H.

    2014-01-01

    Introduction: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. Methods: Twenty-two children with RE (age, mean ± SD: 11.3 ± 2.0 y) and 22 healthy controls (age 10.5 ± 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01–0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. Results: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. Conclusion: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of

  2. Gender Anarchy as Social Justice: An Analytic Reconstruction of the Idea of Epistemic Equality in Jane Roland Martin's "Reclaiming a Conversation"

    ERIC Educational Resources Information Center

    Seals, Greg

    2006-01-01

    Jane Roland Martin's later work, especially as represented in "The Schoolhome: Rethinking Schools for Changing Families," has been attacked as vague, essentialistic, and a formula for the (re)feminization of education. This paper does not attempt to defend Martin against these criticisms because such a defense seems impossible for…

  3. The Genetics of Reading Disability in an Often Excluded Sample: Novel Loci Suggested for Reading Disability in Rolandic Epilepsy

    PubMed Central

    Strug, Lisa J.; Addis, Laura; Chiang, Theodore; Baskurt, Zeynep; Li, Weili; Clarke, Tara; Hardison, Huntley; Kugler, Steven L.; Mandelbaum, David E.; Novotny, Edward J.; Wolf, Steven M.; Pal, Deb K.

    2012-01-01

    Background Reading disability (RD) is a common neurodevelopmental disorder with genetic basis established in families segregating “pure” dyslexia. RD commonly occurs in neurodevelopmental disorders including Rolandic Epilepsy (RE), a complex genetic disorder. We performed genomewide linkage analysis of RD in RE families, testing the hypotheses that RD in RE families is genetically heterogenenous to pure dyslexia, and shares genetic influences with other sub-phenotypes of RE. Methods We initially performed genome-wide linkage analysis using 1000 STR markers in 38 US families ascertained through a RE proband; most of these families were multiplex for RD. We analyzed the data by two-point and multipoint parametric LOD score methods. We then confirmed the linkage evidence in a second US dataset of 20 RE families. We also resequenced the SEMA3C gene at the 7q21 linkage locus in members of one multiplex RE/RD pedigree and the DISC1 gene in affected pedigrees at the 1q42 locus. Results In the discovery dataset there was suggestive evidence of linkage for RD to chromosome 7q21 (two-point LOD score 3.05, multipoint LOD 3.08) and at 1q42 (two-point LOD 2.87, multipoint LOD 3.03). Much of the linkage evidence at 7q21 derived from families of French-Canadian origin, whereas the linkage evidence at 1q42 was well distributed across all the families. There was little evidence for linkage at known dyslexia loci. Combining the discovery and confirmation datasets increased the evidence at 1q42 (two-point LOD = 3.49, multipoint HLOD = 4.70), but decreased evidence at 7q21 (two-point LOD = 2.28, multipoint HLOD  = 1.81), possibly because the replication sample did not have French Canadian representation. Discussion Reading disability in rolandic epilepsy has a genetic basis and may be influenced by loci at 1q42 and, in some populations, at 7q21; there is little evidence of a role for known DYX loci discovered in “pure” dyslexia pedigrees. 1q42 and 7q21 are

  4. The patient-specific functional scale is more responsive than the Roland Morris disability questionnaire when activity limitation is low.

    PubMed

    Hall, Amanda M; Maher, Chris G; Latimer, Jane; Ferreira, Manuela L; Costa, Leonardo O P

    2011-01-01

    The primary objective of this study was to determine which questionnaire, the Roland Morris disability questionnaire (RMDQ) or the patient-specific functional scale (PSFS), was better at detecting change in activity limitation in a large cohort of patients with low back pain undergoing rehabilitation. A secondary aim was to determine if the responsiveness of the questionnaires was influenced by the patient's level of activity limitation at baseline. Responsiveness statistics, including effect size statistics, Pearson's r correlations and receiver operative characteristic (ROC) curve analysis were used to determine ability to detect change in activity limitation on 831 patients with low back pain. Data were analysed at two time points; directly after treatment (termed short-term) and several weeks post-treatment (termed mid-term). The data were subsequently re-analysed on sub-sets of the full cohort according to the level of activity limitation from RMDQ baseline scores. In the total cohort we found that the PSFS was more responsive than the RMDQ; however, in the subgroup with high activity limitation this pattern was not observed. This is true for time points up to 6 months post-treatment. In conclusion, the RMDQ and PSFS both demonstrate good responsiveness according to the definitions given in previous guidelines. The PSFS is more responsive than the RMDQ for patients with low levels of activity limitation but not for patients with high levels of activity limitation.

  5. A Roland Morris Disability Questionnaire Target Value to Distinguish between Functional and Dysfunctional States in People with Low Back Pain

    PubMed Central

    Riddle, Daniel L.

    2016-01-01

    Purpose: To estimate a threshold Roland Morris Disability Questionnaire (RMQ) value that could be used to classify patients with low back pain (LBP) as functional or dysfunctional. Methods: In this secondary analysis of data from a study that estimated clinically important RMQ change scores, participants were adults with LBP attending one of three physical therapy clinics. Diagnostic test methodology and a reference standard of goals met were applied to estimate a threshold RMQ value that best distinguished between participants with a functional status and those whose status was dysfunctional. Results: Of 143 participants, 104 (73%) met their goals. An RMQ threshold value of 4/24 best distinguished between those who met their goals and those who did not. Sensitivity and specificity for a threshold score of 4 were 94% (95% CI, 88–98) and 69% (95% CI, 52–83), respectively. Conclusions: A threshold value of 4 RMQ points provided a reasonably accurate classification of patients. Further research is necessary to cross-validate this estimate and to examine the stability of the estimated value in people with diverse functional demands. PMID:27504045

  6. Comparison of navigated transcranial magnetic stimulation and functional magnetic resonance imaging for preoperative mapping in rolandic tumor surgery.

    PubMed

    Coburger, Jan; Musahl, Christian; Henkes, Hans; Horvath-Rizea, Diana; Bittl, Markus; Weissbach, Claudia; Hopf, Nikolai

    2013-01-01

    Navigated transcranial magnetic stimulation (nTMS) is a novel tool for preoperative functional mapping. It detects eloquent cortical areas directly, comparable to intraoperative direct cortical stimulation (DCS). The aim of this study was to evaluate the advantage of nTMS in comparison with functional magnetic resonance imaging (fMRI) in the clinical setting. Special focus was placed on accuracy of motor cortex localization in patients with rolandic lesions. Thirty consecutive patients were enrolled in the study. All patients received an fMRI and nTMS examination preoperatively. Feasibility of the technique and spatial resolution of upper and lower extremity cortical mapping were compared with fMRI. Consistency of preoperative mapping with intraoperative DCS was assessed via the neuronavigation system. nTMS was feasible in all 30 patients. fMRI was impossible in 7 out of 30 patients with special clinical conditions, pediatric patients, central vascular lesions, or compliance issues. The mean accuracy to localize motor cortex of nTMS was higher than in fMRI. In the subgroup of intrinsic tumors, nTMS produced statistically significant higher accuracy scores of the lower extremity localization than fMRI. fMRI failed to localize hand or leg areas in 6 out of 23 cases. Using nTMS, a preoperative localization of the central sulcus was possible in all patients. Verification of nTMS motor cortex localization with DCS was achieved in all cases. The fMRI localization of the hand area proved to be postcentral in one case. nTMS has fewer restrictions for preoperative functional mapping than fMRI and requires only a limited level of compliance. nTMS scores higher on the accuracy scale than fMRI. nTMS represents a highly valuable supplement for the preoperative functional planning in the clinical routine.

  7. Letting the CAT out of the Bag: Comparing Computer Adaptive Tests and an Eleven-Item Short Form of the Roland-Morris Disability Questionnaire

    PubMed Central

    Cook, Karon F.; Choi, Seung W.; Crane, Paul K.; Deyo, Richard A.; Johnson, Kurt L.; Amtmann, Dagmar

    2009-01-01

    Study Design A post-hoc simulation of a computer adaptive administration of the items of a modified version of the Roland Morris Disability Questionnaire. Objective To evaluate the effectiveness of adaptive administration of back pain-related disability items compared to a fixed 11-item short form. Summary of Background Data Short form versions of the Roland Morris Disability Questionnaire have been developed. An alternative to paper-and -pencil short forms is to administer items adaptively so that items are presented based on a person’s responses to previous items. Theoretically, this allows precise estimation of back pain disability with administration of only a few items. Materials and Methods Data were gathered from two previously conducted studies of persons with back pain. An item response theory model was used to calibrate scores based on all items, items of a paper-and-pencil short form, and several computer adaptive tests (CATs). Results Correlations between each CAT condition and scores based on a 23-item version of the Roland Morris Disability Questionnaire ranged from 0.93 to 0.98. Compared to an 11-item short form, an 11-item CAT produced scores that were significantly more highly correlated with scores based on the 23-item scale. CATs with even fewer items also produced scores that were highly correlated with scores based on all items. For example, scores from a five-item CAT had a correlation of 0.93 with full scale scores. Seven- and nine-item CATs correlated at 0.95 and 0.97, respectively. A CAT with a standard-error-based stopping rule produced scores that correlated at 0.95 with full scale scores. Conclusions A CAT-based back pain-related disability measure may be a valuable tool for use in clinical and research contexts. Use of CAT for other common measures in back pain research, such as other functional scales or measures of psychological distress, may offer similar advantages. PMID:18496352

  8. A Systematic Review of Head-to-Head Comparison Studies of the Roland-Morris and Oswestry Measures' Abilities to Assess Change.

    PubMed

    Newman, Anastasia N L; Stratford, Paul W; Letts, Lori; Spadoni, Gregory

    2013-01-01

    Objectif : Déterminer si la sensibilité au changement des résultats au questionnaire Roland-Morris (Roland-Morris Questionnaire, RMQ) et au questionnaire d'incapacité d'Oswestry (Oswestry Disability Index, ODI) diffèrent lorsqu'on les applique aux patients qui souffrent de lombalgie. Comme objectif secondaire, réaliser une analyse critique de la rigueur méthodologique des études comparatives directes sélectionnées. Méthode : Une revue systématique de cinq bases de données en ligne a été réalisée pour rechercher des études comparatives directes du RMQ et de l'ODI qui évaluaient la sensibilité au changement de ces deux mesures. Les études étaient retenues si elles satisfaisaient à un ensemble de critères d'inclusion préétabli. Un formulaire de critères de qualité nouvellement élaboré a été utilisé pour évaluer la rigueur méthodologique des études comparatives directes. Résultats : Neuf articles satisfaisaient aux critères d'inclusion. Bien que pour deux études, on ait constaté une différence statistique appréciable favorable au RQM, il n'y avait aucun avantage apparent commun pour une mesure plutôt que pour l'autre. Les lacunes méthodologiques fréquentes étaient notamment l'absence de calcul formel de la taille de l'échantillon, l'absence de critère pour la comparaison des mesures et le fait qu'il n'y avait aucune norme de référence indépendante. Conclusion : Il n'y a aucun élément probant commun permettant de privilégier une mesure plutôt qu'une autre. Plusieurs études comportaient des lacunes sur le plan méthodologique.

  9. The Association of Each Disability Based on the Three Sub-Categories of the Roland-Morris Disability Questionnaire during Hospitalization with Itself at 1 Year Postoperatively in Patients with Degenerative Lumbar Spinal Stenosis

    PubMed Central

    Manabe, Nodoka; Ino, Masatake

    2014-01-01

    Study Design A prospective study in a hospital. Purpose To investigate whether each disability based on the three sub-categories of the Roland-Morris disability questionnaire (RDQ) during hospitalization is associated with itself at 1 year postoperatively in patients with degenerative lumbar spinal stenosis (LSS). Overview of Literature Although the total score of the RDQ represents whole pain-related disabilities or health-related quality of life, it is a shortcoming that multi-dimensional changes in disabilities are difficult to understand when only using the RDQ. Methods Fifty-seven patients with LSS (men, 28; women, 29; 63.0±12.1 years) were included. Disabilities, pain intensity and depressive feelings were assessed at preoperation, discharge and 1 year postoperatively. Results The range of "mental and physical activities (MPA)," "functional movements on/around a bed (FM)" and "walking function (WF)" scores were 0 to 13 (median, 8), 0 to 6 (median, 6) and 0 to 4 (median, 3) at preoperation; 0 to 12 (median, 0), 0 to 6 (median, 0), and 0 to 4 (median, 0) at discharge; and 0 to 8 (median, 0), 0 to 5 (median, 0), and 0 to 4 (median, 0) at 1 year postoperatively, respectively. The following significant multiple regression equations were obtained: MPA at 1 year postoperatively=0.56 (MPA at discharge)-0.10 (depression at discharge)+0.90 (adjusted r2=0.41), FM at 1 year postoperatively=0.35 (MPA at discharge)-0.06 (depression at discharge)+0.40 (adjusted r2=0.45) and WF at 1 year postoperatively=0.59 (WF at discharge)-0.08 (depression at discharge)+0.63 (adjusted r2=0.29). Conclusions In our LSS population, each disability based on MPA and WF at discharge is associated with itself in the future. Therefore, disabilities excluding functional movements are longitudinally independent. PMID:24596598

  10. Identification of Reliable Sulcal Patterns of the Human Rolandic Region

    PubMed Central

    Mellerio, Charles; Lapointe, Marie-Noël; Roca, Pauline; Charron, Sylvain; Legrand, Laurence; Meder, Jean-François; Oppenheim, Catherine; Cachia, Arnaud

    2016-01-01

    A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono’s atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono’s atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning. PMID:27582700

  11. Roland: A Case for or Against NATO Standardization?

    DTIC Science & Technology

    1980-05-01

    words linguistically may reflect no more than the draftsman’s best guess as to what to name a part he has just designed. To sort out the differences...faulty translation during his visit to Poland in 1977 embarrassingly revealed, an interpreter must also be a linguist , and possess the pyschological bent...was written without benefit of today’s refined lexicology of RSI. Many combinations of forging, casting, and machining methods were developed, and

  12. [The atypical developments of rolandic epilepsy are predictable complications].

    PubMed

    Pesántez-Ríos, Gabriela; Martínez-Bermejo, Antonio; Arcas, Joaquín; Merino-Andreu, Milagros; Ugalde-Canitrot, Arturo

    2015-08-01

    Introduccion. Las evoluciones atipicas de la epilepsia rolandica son parte de un espectro clinico de fenotipos variables, idiopaticos, dependientes de la edad y con una predisposicion geneticamente determinada. Objetivo. Estudiar las caracteristicas electroclinicas sugestivas de una evolucion atipica en la epilepsia rolandica. Pacientes y metodos. Se realizo una busqueda retrospectiva de 133 niños diagnosticados de epilepsia focal benigna atipica (EFBA), sindrome de Landau-Kleffner y epilepsia de punta-onda continua durante el sueño (POCS). Se seleccionaron nueve pacientes que, en el trascurso de su epilepsia rolandica, presentaron un cuadro clinico atipico y un patron electroencefalografico (EEG) de estado epileptico electrico durante el sueño (ESES). Resultados. El inicio de la epilepsia rolandica fue, en promedio, a los 5 años. Los pacientes presentaron un empeoramiento clinico y del EEG año y medio mas tarde en promedio. En tres pacientes se observaron caracteristicas de EFBA, y en seis, de POCS. No se encontraron casos de sindrome de Landau-Kleffner. El EEG en vigilia mostro una focalidad centrotemporal izquierda en seis pacientes, y derecha, en tres. Todos los pacientes presentaron un ESES en el EEG de sueño. En tres de ellos se observo un patron atipico de ESES regional. Ademas, se detectaron alteraciones cognitivas y conductuales por deficits en areas especificas del aprendizaje, como lenguaje, memoria, atencion e inquietud. Conclusiones. El inicio precoz de la epilepsia rolandica, la aparicion de nuevas crisis con un incremento en su frecuencia y una focalidad frontocentrotemporal en el EEG, que aumenta en frecuencia, tanto en vigilia como en sueño, son caracteristicas electroclinicas sugerentes de una evolucion atipica.

  13. The Roland Maze Project — Cosmic Ray Registration at Schools

    NASA Astrophysics Data System (ADS)

    Feder, J.; JȨDRZEJCZAK, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Tokarski, P.; Wibig, T.

    Experimental studies of cosmic rays at the highest energies (above 1018 eV) are the main scientific goal of the projected large area network of extensive air shower detectors. Placing the detectors on the roofs of high school buildings will lower the cost by using the existing urban infrastructure (INTERNET, power supply, etc.), and can be a very efficient way of science popularisation by engaging high school students in the research program. 30 high schools in Łódź are already involved in the project. The project has recently obtained some financial support from the City Council of Łódź. The donation enabled us to start experimental work on detector construction details. A cycle of lectures and seminars devoted to different aspects of project realization (detector construction, on-line data acquisition system, C++ programming) has been organized for students at our Institute and at schools.

  14. [Neuropsychological alterations are frequent in rolandic epilepsy and its atypical developments].

    PubMed

    Pesantez-Rios, G; Martinez-Bermejo, A; Pesantez-Cuesta, G

    2016-08-01

    Introduccion. La epilepsia rolandica o epilepsia benigna de la infancia con puntas centrotemporales se denomina benigna debido a lo favorables que suelen ser sus crisis y a la espontanea normalizacion del electroencefalograma al llegar a la pubertad, aunque se ha demostrado el impacto sobre el desarrollo cognitivo con la presencia de deficits cognitivos heterogeneos, relacionados especialmente con las descargas intercriticas persistentes durante el sueño no REM. El objetivo de este trabajo es estudiar las redes epileptogenas involucradas en los trastornos neuropsicologicos de esta patologia. Desarrollo. Las evoluciones atipicas tienen en comun una actividad epileptica persistente durante el sueño lento, que desempeña un papel importante en el desarrollo de los deficits neurocognitivos que se asocian a esta patologia. Factores como la edad de inicio de la epilepsia, el inicio de la evolucion atipica, la localizacion de las descargas interictales y la actividad epileptica continua durante el sueño que persista durante mas de dos años pueden provocar cambios en el funcionamiento de las redes neurocognitivas, con los consecuentes deficits en las funciones neuropsicologicas, que incluso pueden resultar irreversibles. Conclusiones. Es necesario un seguimiento cercano tanto clinico como electroencefalografico; ademas, deben realizarse estudios neuropsicologicos formales desde el inicio de la epilepsia benigna de la infancia con puntas centrotemporales y mas en los casos que es evidente una evolucion atipica para detectar y prevenir los deficits neuropsicologicos antes de que se instauren definitivamente.

  15. Roland Barthes, Reading, and Roleplay: Composition's Misguided Rejection of Fragmentary Texts.

    ERIC Educational Resources Information Center

    Seitz, James

    1991-01-01

    Asserts that the act of writing can create surprising, experimental, supple forms of written discourse. Argues for exploring more mobile, heteroglot, polyphonic forms of writing. Suggests that attempting roles that produce fragmentary texts might lead toward approaching the challenges of composing unified texts from a more enlivening perspective.…

  16. The Plural Text/The Plural Self: Roland Barthes and William Coles.

    ERIC Educational Resources Information Center

    Harris, Joseph

    The role of the reader in how the meaning of a text is formed has been a nearly obsessive concern of recent critical thought. While theories of reader-response or deconstruction may seem to have had little effect on the practice of teaching literature, they do hold much in common with the way many teachers try to teach writing. The works of Roland…

  17. The Roland Maze Project school-based extensive air shower network

    NASA Astrophysics Data System (ADS)

    Feder, J.; Jȩdrzejczak, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Wibig, T.

    2006-01-01

    We plan to construct the large area network of extensive air shower detectors placed on the roofs of high school buildings in the city of Łódź. Detection points will be connected by INTERNET to the central server and their work will be synchronized by GPS. The main scientific goal of the project are studies of ultra high energy cosmic rays. Using existing town infrastructure (INTERNET, power supply, etc.) will significantly reduce the cost of the experiment. Engaging high school students in the research program should significantly increase their knowledge of science and modern technologies, and can be a very efficient way of science popularisation. We performed simulations of the projected network capabilities of registering Extensive Air Showers and reconstructing energies of primary particles. Results of the simulations and the current status of project realisation will be presented.

  18. Skin Color-Based Video Segmentation under Time-Varying Illumination

    DTIC Science & Technology

    2003-03-25

    Face and Gesture Recognition , pp. 379–384, 1996. [15] R. Kjeldsen and J. Kender. Finding skin in color images. Proc. International Conf. on Automatic...Face and Gesture Recognition , pp. 312–317, 1996. [16] M. Storring, H.J. Andersen, and E. Granum. Skin colour detection under changing lighting...Object oriented face detection using range and color information. Proc. International Conf. on Automatic Face and Gesture Recognition , pp. 76–81, 1998

  19. Parameter Networks: Towards a Theory of Low-level Vision,

    DTIC Science & Technology

    1981-04-01

    8217Iels suc(h ,-s thiose shown in 1ligure 7 to reorganize origami wo.d- figures. Figoure?7. 1’o show an example In detail, Kender’s techn!Ciue for...Compuiter Science Dept, Carnegie-.Mcllon U., October 1979. Kanade, Tl., "A theory of Origami world," CMU-CS-78-144, Computer Science Dept, Carnegie

  20. Justice: A Problem for Military Ethics during Irregular War

    DTIC Science & Technology

    2008-05-22

    189 (to Boniface),” trans. Roland Teske , ed. Boniface Ramsey (Hyde Park, New York: New York City Press, 2004), 261. 9 society was not the primary...Marcus Dods. New York: The Modern Library, 1950. Augustine. The Works of Saint Augustine. Translated by Roland Teske . Edited by Boniface Ramsey. Hyde

  1. Aping our ancestors

    NASA Astrophysics Data System (ADS)

    Ennos, Roland

    2014-08-01

    Roland Ennos argues that the abilities of the great apes to cope in the dangerous mechanical environment of the forest canopy are part of the human species' intellectual inheritance and are intimately connected with our abilities as physicists.

  2. Structuralism: Its Implications for the Performance of Prose Fiction

    ERIC Educational Resources Information Center

    Hopkins, Mary Francis

    1977-01-01

    Discusses the implications of structuralism by examining "Introduction to The Structural Analysis of Narrative", a contemporary writing by Roland Barthes. Explains Barthes' terms and concepts by using Virginia Woolf's Mrs. Dalloway character for an example. (MH)

  3. Survey of Neural Net Paradigms for Specification of Discrete Networks.

    DTIC Science & Technology

    1988-01-31

    appendix. 23 References 1. Cambier, J.L., Barth , S., Reid, W.J., Barrett,S., "Advanced Pattern Recognition", F30602-80-C-0319. ADA 132 339 2. Elman, J.L...Nov. 1985. ., .U U - - A 1 Bibliography Berge, Claude, "Principles of Combinatorics", Academic Press, 1971 Fischer, Roland , "Deconstructing Reality... Roland W., "Cognitive Strategies in Stochastic Thinking", D. Reidel, 1982(?) Searle, John, "Expression and Meaning", Cambridge U. Press, 1979 Talmy

  4. Gyro and Accelerometer Based Navigation System for a Mobile Autonomous Robot.

    DTIC Science & Technology

    1985-12-02

    8217[ C) ~OF ~ FEB 13 1986 J GYRO AND ACCELEROMETER BASED NAVIGATION SYSTEM FOR A MOBILE AUTONOMOUS ROBOT Roland J. Bloom William J. Ramey, Jr. Captain...ACCELEROMETER BASED NAVIGATION SYSTEM FOR A MOBILE AUTONOMOUS ROBOT THESIS Roland J. Bloom William J. Ramey, Jr. Captain, USAF Captain, USAF AF IT/GA/GE/ENG/85D...MOBILE AUTONOMOUS ROBOT THE SI S Presented to the Faculty of the School of Engineering of the Air Force Institute of Technology Air University In

  5. Marching to a Different Drummer. Military Women in American Popular Magazines, 1975-1985.

    DTIC Science & Technology

    1985-12-30

    16 1 0Roland E . Wolseley, "Social Effects of Magazines," in Mass Media and Communication, ed. Charles S. Steinberg (New York...Military News," Journalism Quar- terly 51 (Autumn 1974): 563-69. 4 6James E . Fletcher and Philip E . Soucy, "Army Public Affairs Officer as Perceived ...pp. 28-32. 8 5Roland E . Wolseley, "Social Effects of Magazines," in Mass Media and Communication, ed. Charles S. Steinberg (New York: Hastings House

  6. JPRS Report, East Europe

    DTIC Science & Technology

    1990-05-04

    j7,712 39.72 Barth , Dr. Janos MDF 16,753 34.78 Kosa, Andras FKgP 4,947 25.48 8 Kiskun- Horvath, Dr. Laszlo FKgP 8,649 58.52 halas Toth, Zoltan SZDSZ 6,129...its beginning stages; it requires the participation of In addition, the management/consulting firm Roland Western leasing firms or banks that...ingrad. Training courses for Soviet cadres * FRG * USSR -Business/administrative consulting of Soviet cadres _ Metal factory Leningrad - Roland Berger and

  7. Bibliographic Annual in Speech Communication: 1974. Volume 5.

    ERIC Educational Resources Information Center

    Kennicott, Patrick C., Ed.

    This annotated bibliography is an annual volume devoted to maintaining a record of graduate work in speech communication, providing abstracts of doctoral dissertations, and making subject area bibliographies available. The contents of this volume include "Studies in Mass Communication: A Selected Bibliography, 1973" by Roland C. Johnson and…

  8. Bullying among Students and Its Consequences on Health

    ERIC Educational Resources Information Center

    Houbre, Barbara; Tarquinio, Cyril; Thuillier, Isabelle; Hergott, Emmanuelle

    2006-01-01

    Violence among students at school is an ever-growing problem. Bullying can be defined as all forms of repeated physical or mental violence performed by an individual on another person who is not capable of defending him/herself (Roland & Idsoe, 2001). The three studies conducted here reveal some of the characteristics and implications of this type…

  9. Representation and Race in America’s Volunteer Military.

    DTIC Science & Technology

    1986-09-01

    H. Wedekind , "GIs in the Klan: A Look Under Their Hoods," Army Times Magazine, 7 July 1980, p. 5. 15 1Charles H. Coates and Roland J. Pellegrin... Wedekind , "CIs in the Klan." A more recent account of the alleged participation by soldiers and marines in KKK activities can be found in Daniel Greene

  10. Determination of the Conductivity and Permittivity of the Surface Material and Monitoring of the Outgassing Activity of the Cometary Nucleus

    NASA Astrophysics Data System (ADS)

    Grard, R.; Laakso, H.; Hamelin, M.; Goldstein, B.; Winterhalter, D.; Kochan, H.; Ulamec, S.

    1996-03-01

    The Permittivity Probe (PP) is one component of the Surface Electrical, Seismic and Acoustic Monitoring Experiments (SESAME). This suite of instruments is presently under consideration as a payload element of Roland, a cometary lander, which is part of the ESA corner stone mission, ROSETTA.

  11. 78 FR 23522 - Idaho Roadless Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ..., Roland Point, Wonderful Peak Idaho Roadless Areas on the Idaho Panhandle National Forests to reflect... had been inappropriately shown as only located on the Idaho Panhandle National Forest instead of split between the Idaho Panhandle and Kootenai National Forests. For purposes of this request for......

  12. Action-perception connection and the cortical mu rhythm.

    PubMed

    Hari, Riitta

    2006-01-01

    The rolandic mu rhythm consists of two main frequency components: one around 10 Hz and the other around 20 Hz. Reactivity of the mu rhythm, especially its motor cortex 20-Hz component, provides an illuminating window to the involvement of the human sensorimotor system in the loop that connects action and perception with the environment.

  13. European Consciousness: Towards Defining a Complex Concept and Its Educational Significance (Europaisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung)

    ERIC Educational Resources Information Center

    Jobst, Solvejg

    2005-01-01

    The present study aims at a definition of "European consciousness". In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmuller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain…

  14. 75 FR 17140 - Sunshine Act; Farm Credit Administration Board; Regular Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ...: Notice is hereby given, pursuant to the Government in the Sunshine Act (5 U.S.C. 552b(e)(3)), of the..., 2010, from 9 a.m. until such time as the Board concludes its business. FOR FURTHER INFORMATION CONTACT: Roland E. Smith, Secretary to the Farm Credit Administration Board, (703) 883-4009, TTY (703)...

  15. Educational Studies of Cosmic Rays with a Telescope of Geiger-Muller Counters

    ERIC Educational Resources Information Center

    Wibig, T.; Kolodziejczak, K.; Pierzynski, R.; Sobczak, R.

    2006-01-01

    A group of high school students (XII Liceum) in the framework of the Roland Maze Project has built a compact telescope of three Geiger-Muller counters. The connection between the telescope and a PC computer was also created and programmed by students involved in the Project. This has allowed students to use their equipment to perform serious…

  16. Building Peace in Warlord Situations

    DTIC Science & Technology

    2002-06-01

    Allie and Roland Wright, “Sierra Leone,” in Comprehending and Mastering African Conflicts, ed. Adebayo Adedeji (New York: Zed Book Ltd, 1999), 185. 45...102 Abass Bundu, Democracy by Force? (United States: Universal Publishers, 2001) 63. 54 document reports of atrocities and

  17. Rheological Behavior of Entangled Polystyrene-Polyhedral Oligosilsesquioxane (POSS) Copolymer (Postprint)

    DTIC Science & Technology

    2006-08-24

    15 mL of CHCl3 and precipitated into 100 mL of methanol. After stirring 1 h, the copolymer was isolated on fritted glassware and air-dried overnight... Ceram . Soc. 1925, 8, 339-355. (58) Carella, J. M.; Gotro, J. T.; Graessley, W. W. Macromolecules 1986, 19, 659-667. (59) Bero, C. A.; Roland, C. M

  18. Das Sprachlabor und der Audiovisuelle Unterricht (The Language Laboratory and Audiovisual Instruction).

    ERIC Educational Resources Information Center

    Freudenstein, Reinhold, Ed.

    Four articles, written in German, discuss such aspects of the language laboratory as: teaching pronunciation in the laboratory (Heinrich Schrand), the dummy-element in transformational grammar (Helmut Heuer), testing in the language laboratory (Kenneth S. Leigh), and language laboratory work in Finland (Roland Freihoff). Nine book reviews on…

  19. Discovery of the Self through the Writing Process: Autobiography as a Heuristic of Identity.

    ERIC Educational Resources Information Center

    Pitts, Mary Ellen

    Although the recent thrust toward writing as interaction with a text has led to de-emphasis of personal-experience writing per se, autobiography, if approached in the context of textuality (in Roland Barthes's sense), can provide a model for writing as a means of discovering one's identity--of interacting with life as text and with the written…

  20. Toward Improving Short-Range Fog Prediction in Data-Denied Areas Using the Air Force Weather Agency Mesoscale Ensemble

    DTIC Science & Technology

    2012-09-01

    Zaveri, Georg A. Grell, Mary C. Barth , 2011: The Aerosol Modeling Testbed: A Community Tool to Objectively Evaluate Aerosol Process Modules. Bull. Amer...of Cloud Ceiling and Visibility for an East Coast Winter Precipitation Event. J. Appl. Meteor., 38, 385–404. Stull, Roland B., 1988: An Introduction

  1. Revision Hope: Writing Disruption in Composition Studies.

    ERIC Educational Resources Information Center

    Jung, Julie

    1997-01-01

    Uses Roland Barthes's metaphor of the "punctum" to explore the transformative potential of disruptions. Argues that writing teachers have been trained to read disruption in texts and classrooms as "evidence of poor taste or failed pedagogy," but that disruptions delay closure and thereby create spaces wherein theories and…

  2. Constructing an Ethical Writer for the Postmodern Scene.

    ERIC Educational Resources Information Center

    Hassett, Michael J.

    The advent of postmodern criticism has brought about numerous changes in the way those in the academy read and teach the reading of texts. From Michel Foucault's "What is an Author?" to Roland Barthes'"The Death of the Author" and beyond, critics and theorists have sought to decrease the author-ity of the material that is read.…

  3. "Fare from the Madding Crowd": The Lighter Side of Error in Student Writing.

    ERIC Educational Resources Information Center

    Vaughn, Gary; Wenner, Barbara

    1999-01-01

    Discusses two intriguing ways of explaining error in student writing--the work of Michel Foucault and the work of Roland Barthes. Describes in-class activities and essay assignments that use these perspectives to help students to reach improved understanding of error in writing. (SR)

  4. No Child Left Behind and the Spectacle of Failing Schools: The Mythology of Contemporary School Reform

    ERIC Educational Resources Information Center

    Granger, David A.

    2008-01-01

    This article discusses what David Berliner (2005) has called the perverse "spectacle of fear" (208) surrounding issues of teacher quality and accountability in contemporary school reform. Drawing principally on the critical semiotics of Roland Barthes' essay, "The World of Wrestling" (1957), it examines the way that this…

  5. A Semiotic Perspective on the Technical and Professional Writing Assignment.

    ERIC Educational Resources Information Center

    Westmoreland, Kay

    1995-01-01

    Uses central ideas from Roland Barthes's essays on connotative semiotics as a rationale for directing students in technical and professional writing classes to develop the critical reflex to analyze and then make judgments about the values implied by connotative systems. (SR)

  6. Nouvelle Critique et dix-neuvieme siecle (New Criticism and the Nineteenth Century)

    ERIC Educational Resources Information Center

    Hytier, Jean

    1970-01-01

    Presents contrasting views of some French literary critics including Georges Poulet, Charles Mauron, Jean-Pierre Richard, Jean-Paul Weber, and Roland Barthes. Paper read at the Annual Meeting of the Modern Language Association of America (MLA) December 28, 1968 in New York, New York. (DS)

  7. Environmental Impact Analysis Process. Final Environmental Impact Statement. Part 2B. Proposed Central Radar System, Over-the-Horizon Backscatter Radar Program

    DTIC Science & Technology

    1987-05-22

    Tritz, Dumont, MW W. J. Doyle, Campbell, MW Bernard Lehman, Tintah, MR Kathleen Barth , Tenney, WN Mrs. Floyd Behrens, Dumont, WN Ray Shuck, Tintah...Mr. & Mrs Walter Armbrust, Wheaton, MI Walter Nosek, Wahpeton, ND Lenora Behrens, Wheaton, MR Roland Bauer, Dumont, MI Mr. & Mrs. Rodney Thiel

  8. 1967: The Birth of "The Death of the Author"

    ERIC Educational Resources Information Center

    Logie, John

    2013-01-01

    Roland Barthes's "The Death of the Author" is a foundational text for scholars who are addressing questions of authorship and textual ownership in English studies and its neighboring disciplines. Barthes's essay is typically presented without significant attention to the circumstances and context surrounding its initial English…

  9. The Body of Persuasion: A Theory of the Enthymeme.

    ERIC Educational Resources Information Center

    Walker, Jeffrey

    1994-01-01

    Examines the primary and not exclusively Aristotelian sources from which a more adequate concept of the enthymeme can be derived. Considers the relevance of that concept to the analysis of modern discourse. Analyzes works by Martin Luther King, Jr., and Roland Barthes as examples of enthymeming. (HB)

  10. Black Superintendents of Selected American Cities.

    ERIC Educational Resources Information Center

    Negro History Bulletin, 1980

    1980-01-01

    Presents photographs of 12 Black superintendents of urban school districts. They are: J. Jerome Harris, Ronald Lewis, Willie W. Herenton, Robert R. Wheeler, Alonzo A. Crim, Roland N. Patterson, Jean Franklin Emmons, Charles R. Thomas, Richard C. Hunter, Arthur Jefferson, Ulysses Byas, and Howard E. White, Sr. (GC)

  11. Goals and Objectives of National Science Policy. Science Policy Study--Hearings Volume 1. Hearings before the Task Force on Science Policy of the Committee on Science and Technology, House of Representatives, Ninety-Ninth Congress, First Session (February 28; March 7, 21, 28; April 4, 1985). No. 46.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Science and Technology.

    These hearings, which focused on the goals and objectives of national science policy, include discussions, questions and answers for the record, and, when applicable, prepared statements. Individuals appearing during the hearings include: (1) George C. Pimentel; (2) Alex Roland; (3) John S. Foster, Jr.; (4) James B. Wyngaarden; and (5) Lewis M.…

  12. Hermeneutic and Cultural Codes of S/Z: A Semiological Reading of James Joyce's "The Boarding House"

    ERIC Educational Resources Information Center

    Booryazadeh, Seyed Ali; Faghfori, Sohila; Shamsi, Habibe

    2014-01-01

    Roland Barthes as a fervent proponent of semiology believes that semiology is a branch of a comprehensive linguistics: it is the study of how language articulates the world. Semiotic codes, the paths of this articulation, accordingly underlie his attention. Barthes in a structural analysis of Balzac's "Sarrasine" in S/Z expounds five…

  13. The Proper Place of Theory in Educational History?

    ERIC Educational Resources Information Center

    Urban, Wayne J.

    2011-01-01

    In this article, the author talks about the proper place of theory in educational history and shares his comments on the essays by Eileen Tamura, Carolyn Eick, and Roland Coloma. Eileen Tamura's positing of most educational historians as practitioners of narrative history is surely on the mark. She invites historians of education to investigate…

  14. Weapons Acquisition. Processes of Selected Foreign Government.

    DTIC Science & Technology

    1986-02-01

    period from 1977 to 1985: (1) 5.56mm calibre assault rifle. (2) Milan and Hot antitank weapon systems. (3) Roland ground-to-air weapon system. (4) AMX 30...and standardization edicts . Awards and penalties are laid on accordingly. (7/17, 13/20) The ministries stand apart from one another in the same way

  15. The Debate on Dominant Culture and Cultural Imperialism

    ERIC Educational Resources Information Center

    Anchan, John P.

    2012-01-01

    In this commentary, the author reviews in depth Roland S. Persson's (2012a) target article. According to him Persson (2012a) presents a convincing argument as he wove through examples and explanations. The idea of superculture connects well with the established neocolonial literature and the North-South/Centre-Periphery debate. From general to…

  16. Low Efficiency Control Measures for Jet Engine Test Cells

    DTIC Science & Technology

    1978-09-01

    replacement cost was based upon filter cost data ob- tained from Mr. Roland Langlois, Owens - Corning Fiberglas Inc., Technical Cen- ter, Granville, Ohio. 3...Torgeson’s theory was used to calculate the collection efficiency of three commercial glass fiber filter media samples obtained from Owens - Corning Fiberglas

  17. Wallace Stevens: A Collection of Critical Essays. Twentieth Century Views Series.

    ERIC Educational Resources Information Center

    Borroff, Marie, Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Marie Borroff, Wallace Stevens, Joseph N. Riddle, Hi Simons, Sister M. Bernetta Quinn, C. Roland Wagner, Harold Bloom, Ralph J. Mills, Jr., Roy Harvey Pearce, Louis L. Martz, Morton Dauwen Zabel, and Northrop Frye--all…

  18. Antibodies to Squalene in US Navy Persian Gulf War Veterans with Chronic Multisymptom Illness

    DTIC Science & Technology

    2009-01-01

    of the Gulf war: cross sectional study. BMJ 2000;320(May (7246)):1363–7 [see comment]. [30] Taylor DN, Sanchez JL, Smoak BL, DeFraites R. Helicobacter ... pylori infection in Desert Storm troops. Clin Infect Dis 1997;25(November (5)):979–82. [31] Haley RW, Hom J, Roland PS, BryanWW, Van Ness PC, Bonte FJ

  19. The Myth in the Discourse.

    ERIC Educational Resources Information Center

    Breen, Myles; Corcoran, Farrel

    Reflecting the ideas of Roland Barthes, this paper examines the nature and importance of myth as a type of speech. The investigation proceeds by discussing myth from the perspectives of both traditional and contemporary disciplines, then considers the universality of myth, its religious impulse, and its functions. Using examples from television…

  20. Trial of Naltrexone and Dextromethorphan for Gulf War Veterans’ Illnesses

    DTIC Science & Technology

    2014-07-01

    Hom J. Is there a Gulf War Syndrome? Searching for syndromes by factor analysis of symptoms. JAMA. 1997;277:215-22. Erratum in: JAMA 1997 Aug 6;278(5...388. 2. Haley RW, Hom J, Roland PS, Bryan WW, Van Ness PC, Bonte FJ, Devous MD Sr, Mathews D, Fleckenstein JL, Wians FH Jr, Wolfe GI, Kurt TL

  1. Impacts of the Fleet Response Plan on Surface Combatant Maintenance

    DTIC Science & Technology

    2006-01-01

    Plan on Surface Combatant Maintenance Roland J. Yardley, Raj Raman, Jessie Riposo, James Chiesa, John F. Schank Prepared for the United States Navy...Command; CDR Robert Johnson, Kevin Alexander, and LCDR Tony Glover of Commander, Naval Surface Forces Atlantic; and CAPT Larry Olsen and Steve Reynolds

  2. The Role of the State and the Social Partners: Mechanisms and Spheres of Influence.

    ERIC Educational Resources Information Center

    Vocational Training, 1992

    1992-01-01

    This serial issue is devoted to clarifying the attitudes of the various parties or "social partners" to vocational training in the Member States of the European Community. Following an editorial introducing the topic are these articles: "The Community Social Dialogue" (Roland Tavitian); "From the Market Jungle to the…

  3. Literary Theory and the Notion of Difficulty. Report Series 4.7.

    ERIC Educational Resources Information Center

    Touponce, William

    The works of French literary theorists Jacques Lacan, Jacques Derrida, and Roland Barthes reflect a view of the text as the primary object of investigation for any discipline in the human sciences. Each of the three has been involved with pedagogical reforms within French cultural institutions: Derrida with the teaching of philosophy, Lacan with…

  4. Philosophy, Children and Liberal Education.

    ERIC Educational Resources Information Center

    Reed, T. M.; Hanna, Patricia

    1981-01-01

    Remarks directed to Peter Augustine Lawler and an earlier article are presented. The rationale for a program of philosophy for children developed at Montclair State College is compared with Roland Garrett's conception of philosophy. Distortions in Lawler's perception of current philosophical practice and teaching are indicated. (MLW)

  5. No Such Thing as a Consensus: Olive Banks and the Sociology of Education

    ERIC Educational Resources Information Center

    Delamont, Sara

    2008-01-01

    The title of this article comes from the editorial written for this journal by Olive Banks, Len Barton, Roger Dale, David Hargreaves, Roland Meighan, Ivan Reid and Graham Vulliamy (Banks et al. 1980, 4) that appeared in its first issue, and set out its remit. The seven scholars who wrote that editorial pledged to "publish high quality work of…

  6. The Scenic Route Is Not Always the Most Informative

    ERIC Educational Resources Information Center

    Freeman, Joan

    2012-01-01

    Roland S. Persson's (2012a) argument is that there is a dominant research culture in the field of gifts and talents, which must of necessity distort research and practice in cultures which are different. He ties this to the dominance of the global economy and points to the need for more cross-cultural studies. In this commentary, the author points…

  7. Benign Childhood Focal Epilepsies: Assessment of Established and Newly Recognized Syndromes

    ERIC Educational Resources Information Center

    Panayiotopoulos, Chrysostomos P.; Michael, Michael; Sanders, Sue; Valeta, Thalia; Koutroumanidis, Michael

    2008-01-01

    A big advance in epileptology has been the recognition of syndromes with distinct aetiology, clinical and EEG features, treatment and prognosis. A prime and common example of this is rolandic epilepsy that is well known by the general paediatricians for over 50 years, thus allowing a precise diagnosis that predicts an excellent prognosis. However,…

  8. The Aims of Education and the Leap of Freedom

    ERIC Educational Resources Information Center

    Yun, SunInn

    2014-01-01

    This paper considers the place of freedom in discussions of the aims of education. Bearing in mind remarks of R.S. Peters to the affect that the singling out of aims can "fall into the hands of rationalistically minded curriculum planners", it begins by considering the views of Roland Reichenbach regarding Bildung and his account of this…

  9. Musical Hunger: A Philosophical Testimonial of Miseducation

    ERIC Educational Resources Information Center

    Laird, Susan

    2009-01-01

    Reflecting upon Simone Weil's conception of beauty as food, this essay proposes musical hunger as a metaphoric way of understanding a particular species of "cultural miseducation" as conceived by Jane Roland Martin, that disadvantages children musically and perhaps therefore also spiritually. It examines such musical miseducation with regard to an…

  10. MX Systems Environmental Programs Scoping Summary.

    DTIC Science & Technology

    1980-04-14

    Phillips Roland Westergard, Director of Conservation and Nat. Res. Robert Hill, State Planning Coordinator James Wadhams, Director of Department of...Health Bureau, Children’s Serv. STATE TIDUSTRIAL ATIRNEY Bureau, Community Serv. Bureau, Consumer Protect. SECRETARY OF STATE Bureau, Dental Health...operations abide by environmental laws? C. What quantities will be required during construction of the following building materialls ? How and when

  11. Numerical Investigation of Dynamic Freefall Penetrometers in Soft Cohesive Marine Sediments Using a Finite Difference Approach

    DTIC Science & Technology

    2010-06-01

    Murff, and others, “Collapse loads for a cylinder embedded in trench in cohesive soil,” International Journal of Geomechanics , vol. 5, 2005, p. 320...International Journal for Numerical and Analytical Methods in Geomechanics , vol. 6, 1982, pp. 47-76. [16] P. Mott, J. Dorgan, and C. Roland, “The

  12. 78 FR 50106 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Bridges of Iowa MPS) 7600 Chavenelle Dr., Dubuque, 13000690 Johnson County Wehner, Roland and Marilyn... 15th to 21st Sts., Cedar Rapids, 13000692 LOUISIANA Madison Parish Tallulah High School, 603 Bayou Dr... Cemetery, Cemetery Rd., Lake Dr., Tuscarawas R., NC 212, 5th, E. 2nd & East Sts., Zoar, 13000701...

  13. 75 FR 22175 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    .... Phillips, Joseph A. Ragan, Mark C. Reineke, David J. Schie, David M. Sims, Roland D. Spaniol, Kevin Stein... have 3 years of recent experience driving a CMV with the vision deficiency: Christopher D. Black, Kevin.... Georgeff, Joseph Revis, Jr., Lawrence C. Smoak, III, David C. Watson, Paula L. Wharton. One...

  14. On Universals, Cultural Variations and Individual Uniqueness: Throwing down the Gauntlet in Giftedness Research

    ERIC Educational Resources Information Center

    Garces-Bacsal, Rhoda Myra

    2012-01-01

    Roland S. Persson's (2012a) piece is extremely comprehensive, timely and very relevant especially in light of a growing appreciation of cultural diversity and the emergence of a global community--which is an inevitable offshoot of globalisation that goes beyond world economy and international markets. It covers multiple themes; ranging from…

  15. What's Foucault Got to Do with It? History, Theory, and Becoming Subjected

    ERIC Educational Resources Information Center

    Butchart, Ronald E.

    2011-01-01

    The three essays that make up this issue on theory in educational history by Eileen Tamura, Caroline Eick, and Roland Sintos Coloma constitute an indictment of the field of the history of education for its neglect of theory. Read linearly, from the Introduction through Coloma, the indictment becomes increasingly strident, moving from a gentle call…

  16. PSynUTC - Evaluation of a High-Precision Time Synchronization Prototype System for Ethernet LANs

    DTIC Science & Technology

    2002-12-01

    now been taken over by our spin-off company Oregano Systems (http://www.oregano.at). Roland Höller, Nikolaus Kerö Department of Computer Technology... Oregano Systems, will demonstrate the feasibility of GPS time distribution and time synchronization in Ethernet- based LANs with a worst-case

  17. Simulation Development for Silo Test Program (STP). Volume 2. Detonation Characterization of NA/NP (Aqueous Nitric Acid/Nitropropane) and NPN (Nitropropane Nitrate).

    DTIC Science & Technology

    1984-03-31

    for advice and information on NPN; and Dr. Roland Franzen, Ford Laboratories, Inc., for discussions on NPN. Within SRI, we thank Mr. Darwin R. Henley...for constructing the targets, Mr. Daniel F. Walter for operating electronic instrumentation, Mssrs. Hugh E. Hanna, George S. Cartwright , and Kennard E

  18. Geomorphic Mapping Pool 7 - Upper Mississippi River Basin

    DTIC Science & Technology

    1987-10-05

    in the conversion of raw organic material to humus , the mixing of organic and inorganic material, the creation of channels, and the vertical...Mississippi River, Quaternary Research 20: 165-176. GALLAGHER, JAMES P., ROLAND RODELL, and KATHERINE STEVENSON , 1982, The 1980-1982 LaCrosse Area

  19. Empire: An Analytical Category for Educational Research

    ERIC Educational Resources Information Center

    Coloma, Roland Sintos

    2013-01-01

    In this article Roland Sintos Coloma argues for the relevance of empire as an analytical category in educational research. He points out the silence in mainstream studies of education on the subject of empire, the various interpretive approaches to deploying empire as an analytic, and the importance of indigeneity in research on empire and…

  20. Strategies of Organizational Survival: The Case of a National Program for Educational Reform

    ERIC Educational Resources Information Center

    Corwin, Ronald G.

    1972-01-01

    Describes a series of strategies that enabled a nationwide government program, the Teacher Corps, to survive, despite formidable external and internal constraints, and suggests some general patterns that may apply to other cases. Comments by Richard A. Graham and Roland L. Warren. (Author)

  1. Thymic emigration: conveyor belts or lucky dips?

    PubMed

    Scollay, R; Godfrey, D I

    1995-06-01

    The thymic medulla has always seemed a rather uncomplicated compartment, simply storing mature thymocytes until they are exported to the peripheral lymphoid organs. However, as discussed here by Roland Scollay and Dale Godfrey, a careful look at recent data suggests that events in the medulla may be more complex and protracted than previously thought.

  2. The Time Is Ripe (Again)

    ERIC Educational Resources Information Center

    Barth, Roland S.

    2013-01-01

    "It's always been a promising time for teacher leadership. It's just never been a successful time," writes noted educator Roland Barth. Why? Barth points to five obstacles: administrator resistance, the taboo in teaching against elevating oneself higher than one's peers, the fact that teachers' plates are full, the…

  3. The Cenozoic Diversity of Agglutinated Foraminifera - Evidence for a late Oligocene to early Miocene diversification event

    NASA Astrophysics Data System (ADS)

    Kaminski, Michael; Setoyama, Eiichi; Kender, Sev; Cetean, Claudia

    2014-05-01

    The agglutinated foraminifera are among the most abundant micro-organisms in the deep marine environment and have a diversity record extending back to the late Precambrian. We present an updated diversity curve for agglutinated foraminiferal genera based on the stratigraphic ranges of all the agglutinated genera recognized as valid in the classification of Kaminski (2014). The data set for this analysis is based on the stratigraphic ranges of agglutinated genera published in Foraminiferal Genera and their Classification, which has been subsequently updated based on published studies and our new observations. The mean standing diversity of agglutinated foraminiferal genera was compiled by counting the number of boundary crossers rather than the number of genera in each stage. In this study, we report the stratigraphic and geographical occurrence of a benthic foraminiferal diversification event that has previously received little attention. In the latest Oligocene to earliest Miocene a number of trochospiral agglutinated genera with alveolar or canaliculate walls first appeared in the fossil record. Our studies of late Oligocene of the Congo fan, offshore Angola (Kender et al., 2008; Cetean and Kaminski, 2011) have revealed a diverse assemblage that includes new taxa of deep-water agglutinated foraminifera. In a biostratigraphic study of the Miocene foraminiferal assemblages Kender et al. (2008) noted steadily increasing diversity and proportions of infaunal agglutinated foraminiferal morphotypes over the lower Miocene interval. The proportion of infaunal agglutinated foraminifera assigned to the order Textularida increased dramatically in the lower mid-Miocene, suggesting expansion of the oxygen minimum zone into deeper waters. In addition to the trochospiral alveolar genera, several species of Reticulophragmium and Cyclammina display rapid diversification into numerous separate lineages that are at present not reflected in our generic diversity record owing to

  4. Naval Biodynamics Laboratory 1993 Command History

    DTIC Science & Technology

    1993-01-01

    Institute for Perception, TNO Soesterberg, The Netherlands LCDR Jeff Blevins Navy Foreign Liaison Office, Washington, D.C. Mr. James Bost NAVSEA 05D7...Naval Sea Systems Command, Washington, D.C. Captain T. Jones Naval Health Research Center, San Diego, CA Dr. Jeff Keuhn University of Oklahoma, Norman, OK...National Defence Research Establishment firsoirden, Sweden Mr. Roland Palmer Coastal Systems Station, Panama City, FL Mr. Bill Patten University of Oklahoma

  5. Preparing Brigade Combat Team Soldiers for Mission Readiness Through Research on Intangible Psychological Constructs and Their Applications: Phase 1

    DTIC Science & Technology

    2014-02-01

    symptoms than the control group. In addition, the group that received the intervention showed greater improvement in explanatory style , hopelessness...defined as “a personality attribute that reflects the courage and motivation to cope effectively with the stressors of daily life” (Vogt, Rizvi, Shipherd...outcomes such as stressors, strains, social support, coping , and performance (Bartone, 1999; Bartone, Roland, Picano, & Williams, 2008; Dolan

  6. Al Qaeda’s Millenarian Doctrine: Implications for US Policy

    DTIC Science & Technology

    2010-03-15

    Alfred A. Knopf, 2006), 47. 15 Roland Jacquard, In the Name of Osama Bin Laden: Global Terrorism and the Bin Laden Brotherhood (Durham, Duke...C8591-988.xml. 24 Lawrence Wright, The Looming Tower: Al Qaeda and the Road to 9/11, (New York, Alfred A. Knopf, 2006), 37. 25 Mark R. Reiff...Barracks, PA: US Army War College, 2010), 362. 35 Paul Kennedy and William I. Hitchcock , From War to Peace: Altered Strategic Lascapes in the Twentieth

  7. 737 Windshear Tests, Orlando

    NASA Technical Reports Server (NTRS)

    1992-01-01

    NASA researchers evaluating wind shear sensor displays in the experimental flight deck at NASA's Boeing 737 research aircraft. During this flight test program, over 75 microbursts were penetrated at altitudes from 800-1100 ft to test the performance of radar, lidar and infrared wind shear sensors. Pictured from left to right are Wind Shear Program Manager Roland Bowles, NASA research pilot Lee Person, Wind Shear Program Deputy Manager Michael Lewis, NASA research engineer David Hinton, NASA research engineer Emedio Bracalante.

  8. Concurrent validity of questionnaire and performance-based disability measurements in patients with chronic nonspecific low back pain.

    PubMed

    Reneman, Michiel F; Jorritsma, Wim; Schellekens, Jan M H; Göeken, Ludwig N H

    2002-09-01

    This study aimed to investigate the concurrent validity of two approaches to disability measurement in patients with chronic nonspecific low back pain (CLBP). It was hypothesized that if both are measuring the same construct, the instruments would lead to similar disability results and would correlate strongly (r > 0.75). The study compared the results of self-reported and performance-based measures of disability in 64 consecutive patients with CLBP. Participants mean age was 38.0 years, the mean duration of the current episode of back pain 9.9 months, and 90% were off work due to CLBP. The self-report measures used were: the Roland Disability Questionnaire (Roland); the Oswestry Disability Questionnaire (Oswestry); and the Quebec Back Pain Disability Questionnaire (Quebec). Performance was measured using the Isernhagen Work Systems Functional Capacity Evaluation (FCE). The mean scores from the self-report measure are as follows: Roland 13.5 (scale 0-24), Oswestry 28.2 (scale 0-100), Quebec 37.8 (scale 0-100) consistent with moderate to severe disability. In contrast the results from the performance-based measures suggested that the subjects should be able to work at a physical intensity level of moderate to heavy. Little to moderate correlation was observed between the self-report and performance-based measures (Spearman rank correlations: Roland-FCE (-0.20), p > 0.05; Oswestry-FCE (-0.52), p < 0.01; Quebec-FCE (-0.50), p < 0.01). Results are interpreted to suggest that both performance-based and self-report measures of disability should be used in order to obtain a comprehensive picture of the disability in patients with CLBP.

  9. A Brain-Based Communication and Orientation System

    DTIC Science & Technology

    2014-10-06

    imagined speech .” This project thereby sought to facilitate the DoD’s mission by providing assessments that could eventually lead to improvements...an accurate assessment of the user’s intentional focus, eye movements, and imagined speech .” This project thereby sought to facilitate the DoD’s...Nicholas Szrama, Jarod Roland, Zac Freudenberg, Jamie Solis, Jonathan Breshears, Gerwin Schalk. Using the electrocorticographic speech network to control

  10. Functional magnetic resonance imaging before and after ventriculoperitoneal shunting for hydrocephalus--case report.

    PubMed

    Fukuhara, T; Luciano, M G; Liu, J Z; Yue, G H

    2001-12-01

    A 70-year-old man with hydrocephalus was examined with functional magnetic resonance (fMR) imaging before and after ventriculoperitoneal shunting. Preoperatively, activation by right hand exercise revealed only a slight signal increase in the peri-rolandic area. However, 3 months after ventriculoperitoneal shunting, a significant signal increase was observed. fMR imaging may detect activity-related improvement of cerebral blood flow responses in patients with hydrocephalus after surgical treatment.

  11. Aircraft Survivability. Spring 2009

    DTIC Science & Technology

    2009-01-01

    Surviving an Aircraft Crash with Airbag Restraintsby Thomas Barth Inflatable restraint solutions have improved the survivability of commercial...Surviving an Aircraft Crash with Airbag Restraints by Thomas Barth Transport Aircraft Interiors The AmSafe Aviation Airbag entered service on commercial...all night.” Keithley also noted that, in his early days at BRL, Walt teamed up with a group of like-minded innovators, including Jim Foulk, Roland

  12. Is the Philippines Profiting From the War on Terrorism?

    DTIC Science & Technology

    2004-06-01

    wrest a rifle from his army captors. On 18 February 2003 Mujib Susukan, effectively the ASG’s third-ranking Sulu commander, was mortally wounded in...explosives at mobile sites on Jolo. Former hostage Roland 111 Ullah noted the Indonesians told him they were JI operatives and had themselves originally...to support the operation of government forces against terrorist organizations. February. Mujib Susukan, effectively the ASG’s third-ranking

  13. Flow Control Technology

    DTIC Science & Technology

    2010-07-01

    cm. In a similar fashion, the blades are exchangeable. For the results presented here, a blade chord of 50mm with a symmetric NACA 0015 hydrofoil ...Skogsberg and Roland [3]. Each propeller blade assembly is composed of a mounting bracket (1), Hydrofoil Shaft Bracket (2), Blade Servo (3), NACA 0015... Hydrofoil (4), Hydrofoil Shaft Connection (5), and Motor Bracket (6). This set-up can be seen in schematics of Figure 14. Blade 3’s Hydrofoil Shaft

  14. Session: Reservoir Technology

    SciTech Connect

    Renner, Joel L.; Bodvarsson, Gudmundur S.; Wannamaker, Philip E.; Horne, Roland N.; Shook, G. Michael

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five papers: ''Reservoir Technology'' by Joel L. Renner; ''LBL Research on the Geysers: Conceptual Models, Simulation and Monitoring Studies'' by Gudmundur S. Bodvarsson; ''Geothermal Geophysical Research in Electrical Methods at UURI'' by Philip E. Wannamaker; ''Optimizing Reinjection Strategy at Palinpinon, Philippines Based on Chloride Data'' by Roland N. Horne; ''TETRAD Reservoir Simulation'' by G. Michael Shook

  15. AMEDD Clinical Psychology Short Course Held in Fort Gordon, Georgia on 13-17 February 1989

    DTIC Science & Technology

    1990-06-01

    separate psychology ’service; forensic psychology; health psychology; stress. tACT (Continue on reverse if necessary and idjntify by block numberP h...Investigation 77 v Joseph Frey, III and Greg S. Swanson > American Board of Professional Psychology (ABPP) Examination 90 Edward 0. Crandell Military Forensic ...Psychology 94 Gregory A. Gahm Forensic Psychology: Role of the Military Psychologist, 105 Robert R. Roland and Dennis M. Kowal The Psychologist’s

  16. Data-Based Methods for AB Initio Protein Structure Prediction

    SciTech Connect

    Dr Keith L. Frost

    2002-11-07

    OAK 270 - Per the DOE Project Officer ''Roland Hirsh'' Germantown, Md. The required final report for this award has been waived due to the fact Dr Keith Frost who was the P.I. on the research took a leave of absence at the end of March 2000, and left the university without an approval. The University adjusted their records to reflect this early termination; no further funding applied.

  17. Fireworks under the microscope: a spectacular new species of Zodiomyces from the Thaxter collection.

    PubMed

    Rossi, Walter; Haelewaters, Danny; Pfister, Donald H

    2016-01-01

    A new species of Zodiomyces (Ascomycota, Laboulbeniales) is described, Z. rhizophorus, parasitic on a hydrophilid beetle (Coleoptera, Hydrophilidae) from Trinidad. This species was discovered during the examination of the slides of Laboulbeniales made by Roland Thaxter. It is characterized by numerous long, slender, multicellular and multiseriate outgrowths at the base of the receptacle. Thaxter's outstanding illustrations have set a standard in the field of mycology; we provide a review of the methods he employed in the preparation of these illustrations.

  18. Impact of Erb-B Signaling on Myelin Repair in the CNS Following Virus-Induced Damage

    DTIC Science & Technology

    2008-03-01

    demyelinating disease. Microb Pathog 3, 319-326 (1987) 11. Richard J. Clatch, Stephen D. Miller, Roland Metzner, Mauro C. Dal Canto, and Howard L. Lipton...176, 244-254 (1990) 12. Mauro C. Dal Canto and Howard L. Lipton: Ultrastructural immunohistochemical localization of virus in acute and chronic...initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 11, 335-339 (2005) 18. Mauro C. Dal Canto and Howard L. Lipton: Primary

  19. The International Legal Ramifications of United States Counter-Proliferation Strategy: Problems and Prospects

    DTIC Science & Technology

    1997-01-01

    following individuals for their support throughout this sometimes tortuous process: Lynne Wurzburg, Esq., Dr. William G.D. Frederick , Roland Young...Esq., Ms. Maria Kelly, and Sarah A. Wagman, Esq. I also must express my deepest gratitude to Mrs. Geralyn Frederick , whose strength throughout her...Presiden t F.W. De Klerk admitted that South Africa at one time possessed a small number of nuclear warheads; however, according to De Klerk , South

  20. TSA - a Two Scale Approximation for Wind-generated Ocean Surface Waves

    DTIC Science & Technology

    2013-01-01

    aquaculture , coastal transportation. Better forecasts, with longer lead-time, and better accuracy can help reduce potential risk to these economic...developments, due to ocean waves. Quality of Life Development of the coastal zone involves residences, recreation, fisheries, aquaculture , coastal...Babanin, J. F. Filipot, R. Magne, A. Roland, A. van der Westhuysen, P. Queffeulou, J. M. Lefevre, L . Aouf, and F. Collard (2010), Semiempirical

  1. Kosovo’s Support of NATO Stability and Humanitarian Operations

    DTIC Science & Technology

    2013-12-13

    http://www.km.gov.al/?fq=brenda&m=news&lid= 7742& gj =gj1 (accessed November 6, 2013). 47Ministry of the Kosovo Security Force, Annual Report 2012...doctrine on stability operations. Lawrence A. Yates in his book The US military’s experience in Stability Operations 1789-2005 states “ If...US stability operations identified by Yates . However, Roland Paris in At War’s End contends that- the Haiti and Somalia cases can not be considered

  2. Performance Analysis of Live-Virtual-Constructive and Distributed Virtual Simulations: Defining Requirements in Terms of Temporal Consistency

    DTIC Science & Technology

    2009-12-01

    owned and not proprietary. It is managed by the SIMAF facility located at WPAFB, OH. 115 Bibliography BCE+06. Dean Bowley, Paul Comeau, Roland Edwards... Paul J. Hiniker, Geoff Howes, Richard A. Kass, Paul Labbé, Chris Morris, Rick Nunes-Vaz, Jon Vaughan, Sophie Villeneuve, Mike Wahl, Kendall Wheaton...Narayanan. Design & Imple- mentation of Virtual and Constructive Simulations Using OpenEaagles. Linus Publications, 2009. 119 RJL+97. Maria Roussos

  3. Who Pioneered the Use of Antipsychotics in North America?

    PubMed Central

    Stip, Emmanuel

    2015-01-01

    Objective: Neuroleptics were introduced into North America 60 years ago. The credit for this advance is generally accorded to Heinz Lehmann. I sought to explore whether Lehmann really was the first North American psychiatrist to study the effects of chlorpromazine (CPZ) and to provide a more balanced view of its application in a clinical context. Method: I searched for historical documents and published articles in several libraries and interviewed psychiatrists active from 1952–1970. Results: The first article in English was published in the July volume of the Archives of Neurology and Psychiatry in 1954 (n = 71). Another article, written in French by Roland Saucier and published in a journal called Le Saguenay Médical, also described the effects of CPZ on a Canadian psychiatric population in August 1954 (n > 200). However, the first prescription for CPZ was written by Roland Saucier, who brought the product back from Paris after a fellowship there. Ruth Kajander, in Ontario, was also one of the first prescribers of this drug, following her study of its use in anesthesia and a publication in the proceedings of a symposium. Conclusion: The contents of the 2 naturalistic studies were compared. Lehmann’s study started 1 month before that of Saucier. Lehmann was the first North American psychiatrist to publish an article on CPZ, but Roland Saucier nevertheless made an important contribution, being the first to prescribe this drug in North America and reporting results for a study with a sample size 3 times that of Lehmann’s study. PMID:25886681

  4. A predictive modeling approach to analyze data in EEG-fMRI experiments.

    PubMed

    Ferdowsi, Saideh; Sanei, Saeid; Abolghasemi, Vahid

    2015-02-01

    In this paper, a novel technique based on blind source extraction (BSE) using linear prediction is proposed to extract rolandic beta rhythm from electroencephalogram (EEG) recorded in a simultaneous EEG-fMRI experiment. We call this method CLP-BSE standing for constrained-linear-prediction BSE. Extracting event-related oscillations is a crucial task due to nonphase-locked nature and inter-trial variability of this event. The main objective of this work is to extract rolandic beta rhythm to measure event-related synchronization (ERS) with acceptable signal-to-noise ratio (SNR). The extracted rhythm is utilized for constructing a regressor to analyze functional magnetic resonance imaging (fMRI). The proposed method is a semi-blind technique which uses a spatio-temporal constraint for beta rhythm extraction. This constraint is derived from recorded EEG signals based on the prior knowledge about the frequency and location of the source of interest. The main reason of employing linear prediction as an effective algorithm to extract the EEG rhythm is the ability of extracting sources which have specific temporal structure. Performance of the proposed method is evaluated using both synthetic and real EEG data. The obtained results show that the proposed technique is able to extract ERS effectively. The maximum percentage of ERS obtained by filtering is 152% while the obtained ERS by CLP-BSE is 214%. In another experiment, the extracted event-related oscillations in beta band are used to make the necessary regressor for fMRI analysis. The results of EEG-fMRI coregistration confirm that there are correlation between the extracted rolandic beta rhythm and simultaneously recorded fMRI. This conclude that, the results of EEG-fMRI combination support the reliability of CLP-BSE output.

  5. European Geophysical Society (23rd) General Assembly, Annales Geophysicae, Part 4, Nonlinear Geophysics & Natural Hazards, Supplement 4 to Volume 16, Held in Nice, France on 20-24 April 1998

    DTIC Science & Technology

    1998-01-01

    INSTABILITIES AND TURBULENCE IN THE SOLAR WIND Roland Grappin and Jacques Leorat Observatoire de Meudon, D.A.E.C, 92195 Meudon, France. In view of...and Jean -Philippe Laval (2) (1) Mathematics Institute/University of Warwick COVENTRY CV4 7AL, UK, (2) CNRS, URA 2052, CEA/DAPNIA/SAp L’Ormedes...AN URBAN AREA R. Läzaro, V. Pinto , L. Rivera, J.L. Roca and A. Casas G.P.P.G., Facultat de Geologia. Univ. Barcelona (Spain) Barcelona is situated

  6. Spatial disorientation in right-hemisphere infarction.

    PubMed Central

    Meerwaldt, J D; van Harskamp, F

    1982-01-01

    Spatial orientation was tested with the rod orientation test. The subjects were 40 normal controls and 68 brain-damaged patients with cerebral infarcts. Patients in whom the lesion included the post-rolandic region of the right hemisphere performed worse than controls or patients with lesions at other sites. Patients with an exclusively postrolandic (usually occipital) lesion showed higher error rates than patients with a combined prerolandic and postrolandic lesion, but only for the visual part of the test. These patients were re-examined one year after the stroke. Most of them showed an incomplete recovery of spatial function. PMID:7119828

  7. The Antiaircraft Journal. Volume 94, Number 3, May-June 1951

    DTIC Science & Technology

    1951-06-01

    action. Its fast rate of fire and extremely effective fire power make it outstanding for this purpose. Brig. Gen. George B. Barth , Com- manding General...the command posts of Generals Barth . Church, Dean. She writes an engaging story in a simple and irresistible style. Perhaps i\\liss Higgins was not the...to XV Corps, Camp Polk. La. McCravey, James 1.., to 344th ASU AA, Camp Stewart. Ga. Mc~amee. Roland W., to 4054th ASC, AA and GM Br Art\\’ Sch. Ft

  8. Sexuality degree zero: pleasure and power in the novels of John Rechy, Arturo Islas, and Michael Nava.

    PubMed

    Ortiz, R L

    1993-01-01

    "Sexuality Degree Zero" explores common themes and formal strategies in the fiction of three prominent gay Chicano writers: John Rechy, Arturo Islas, and Michael Nava. Employing the concept of a politicized textual "pleasure" as theorized by French critic Roland Barthes, the study argues for the political efficacy of aesthetic choices characteristic to the three authors. Analyses of Rechy's use of pornography, of Islas' transgressive use of cultural iconography, and of Nava's use of sexual "perversions" in the context of classic crime fiction, all go to demonstrate the various uses of pleasure in the construction of a doubly marginalized but defiant self and voice in fiction by gay Chicano men.

  9. Evaluation of the Effectiveness of the Defense Systems Acquisition Review Council (DSARC). Volume I. Technical Report with Appendices A and B.

    DTIC Science & Technology

    1983-04-04

    Roland 11 Perry Nelson* Hacker Murray 6/79 NAVSTAR 11 Dineen’ Shorey’ Hessler’ Murray 11/79 Copperhead 11 LaBerge * Pinie Wacker Murray 1/SO FYS III... LaBerge ’ Danzig’ Uarshman’ Christie’* 10/80 FVS PR LaBerge ’ Danzig* Bting Cua 6/82 LAMPS III Wade* Leach’ Heth h % Not a principal. "no appointee, actg...to illustrate the situation: FVS Program Review 1/80 LaBerge *Danzig* Harshman*Christie* Program Review 10/80 LaBerge *Danzig* Borsting Murray TRIDENT

  10. [Recommendations for a basic functional assessment of low back pain].

    PubMed

    Demoulin, C; Fauconnier, C; Vanderthommen, M; Henrotin, Y

    2005-01-01

    This article aims to recommend easy, reproducible and valid physical tests and questionnaires to allow a functional and physical assessment of sub-acute and chronic low back pain patients. We recommend the pain visual analogue scale, the French translation of the Roland-Morris Disability Questionnaire (EIFEL) and the Dallas questionnaire to appreciate pain intensity and its influence on patients' quality of life. Sorensen's test is recommended in order to assess trunk extensor muscles endurance. We suggest to measure pelvic and lumbar flexion mobility by means of the inclinometer technique. The test described by McQuade is recommended to assess abdominal muscles static endurance.

  11. History of the early dipteran systematics in Italy: from Lyncei to Battista Grassi.

    PubMed

    Baccetti, B

    2008-12-01

    This presentation starts with Galileo's discovery of the microscope and the first Lyncei. Giovanni Heckius and Francesco Stelluti demonstrated different kinds of mosquitoes. Later, in Florence, the Academy of Cimento solved the problem of mosquito reproduction with the discoveries of Francesco Redi, Pietro Paolo da Sangallo, Giuseppe Del Papa and Giovanni Maria Lancisi in the 18th century. In 19th century Eugenio Ficalbi reviewed the Italian Culicids. Once Battista Grassi solved the cycle of Anopheles and Plasmodia, further researches followed by Golgi, Celli, Marchiafava, Bastianelli and Bignami, as well as by Roland Ross.

  12. On the R-Dependence of the Spin-Orbit Coupling Constant: Potential Energy Functions of Xe2+ by High-Resolution Photoelectron Spectroscopy and ab initio Quantum Chemistry

    DTIC Science & Technology

    2008-01-01

    thank Professor Dr. Laura Gagliardi and Professor (1978). Dr. Roland Lindh for helpful discussions regarding the usage 41W. R. Wadt, J. Chem. Phys. 68...Karlstrdm, R. Lindh , P.-A. Malmqvist, B. 0. Roos, U. Ryde, V. Verya- 6 B. J. Whitaker, C. A. Woodward, P. J. Knowles, and A. J. Stace, J. Chem. zov, P...Reiher and A. Wolf, Phys. Lett. A 360, 603 (2007). 3J. Fedor, R. Parajuli, S. Matt-Leubner, 0. Echt, E Hagelberg, K. Gluch, B. 0. Roos, R. Lindh , P-A

  13. Air resistance measurements on actual airplane parts

    NASA Technical Reports Server (NTRS)

    Weiselsberger, C

    1923-01-01

    For the calculation of the parasite resistance of an airplane, a knowledge of the resistance of the individual structural and accessory parts is necessary. The most reliable basis for this is given by tests with actual airplane parts at airspeeds which occur in practice. The data given here relate to the landing gear of a Siemanms-Schuckert DI airplane; the landing gear of a 'Luftfahrzeug-Gesellschaft' airplane (type Roland Dlla); landing gear of a 'Flugzeugbau Friedrichshafen' G airplane; a machine gun, and the exhaust manifold of a 269 HP engine.

  14. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    SciTech Connect

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  15. The European Micropaleontological Reference Centre in Kraków

    NASA Astrophysics Data System (ADS)

    Kaminski, Michael; Waskowska, Anna; Bebenek, Slawomir; Pilarz, Monika

    2016-04-01

    We are pleased to announce the establishment of the European Micropaleontological Reference Centre, housed in the offices of Micropress Europe at the AGH University of Science & Technology in Krakow, Poland. The new European Micropaleontological Reference Centre is an initiative of the Grzybowski Foundation and Micropress Europe. The centre is designed to serve the micropaleontological community by providing a permanent repository or "museum" for published microfossil collections. The centre houses a growing collection of microfossils picked into faunal slides, as well as a well-stocked library of micropaleontological books, journals, and reprints. We have the only up-to-date paper copy of the Ellis & Messina Catalogue of Foraminifera in Central Europe. Currently, the slide collections include: - Type slides of benthic foraminifera from Poland (the collection of I. Heller from the Polish oil company GEONAFTA), - Carboniferous foraminifera from Germany and Poland (collections of G. Eickhoff and Z. Alexandrowicz), - IODP sites in the Arctic, Atlantic, and Indian Oceans (collections of M. Kaminski, E. Setoyama, A. Holborn), - Exploration wells in the Boreal seas: North Sea, Norwegian Sea, Western Barents Sea, Labrador Sea, Bering Sea, Spitsbergen, Western Siberia (collections of M. Kaminski, J. Nagy, T. Van Den Akker, V. Podobina, and others), - Paratethyan Foraminifera (collections of E. Luczkowska, C. Beldean, F. Szekely), - Mesozoic-Paleogene Foraminifera from Gubbio, Italy (collections of M. Kaminski, C. Cetean, and students) and the Polish Carpathians (collection of A. Waskowska), - Caribbean (collection of M. Kaminski, R. Preece), West Africa (collection of R. Preece, S. Kender, C. Cetean), - We have a separate collection of type specimens of species (paratypes). Slides are housed in cabinet drawers together with the relevant publication. Researchers are welcome to visit the offices of Micropress Europe to view the archived microfossil collections. The center

  16. Infarct topography and hemiparesis profiles with cerebral convexity infarction: the Stroke Data Bank.

    PubMed Central

    Mohr, J P; Foulkes, M A; Polis, A T; Hier, D B; Kase, C S; Price, T R; Tatemichi, T K; Wolf, P A

    1993-01-01

    For the 183 of 1276 patients in the NINDS Stroke Data Bank with convexity infarction in the middle cerebral artery territory, the size of the infarct did not differ between the two sides but the location of the main site of the infarct differed: on the left side, it was centred in the inferior parietal region, and was mid-frontal on the right. There was a good correlation between infarct size and weakness severity whether estimated by overall motor function on one side, arm, or hand alone. There was a poor correlation, however, for lesion location (lower third, middle third or upper third on either side of the Rolandic fissure) and any of the specific syndromes of focal weakness, no two cases sharing the same lesion for the same syndrome and several cases sharing the same lesion with a different syndrome. The findings indicated a difference in weakness syndromes between the two hemispheres and great individual variation of the acute syndrome caused by a given site of focal infarction along the Rolandic convexity. These variations may explain some of the difficulties showing effects of a given therapeutic agent in studies of acute ischaemic stroke. Large sample sizes will be required for the reliable assessment of any treatment using currently popular clinical stroke scales. Images PMID:8482953

  17. Sensorimotor activation related to speaker vs. listener role during natural conversation.

    PubMed

    Mandel, Anne; Bourguignon, Mathieu; Parkkonen, Lauri; Hari, Riitta

    2016-02-12

    Although the main function of speech is communication, the brain bases of speaking and listening are typically studied in single subjects, leaving unsettled how brain function supports interactive vocal exchange. Here we used whole-scalp magnetoencephalography (MEG) to monitor modulation of sensorimotor brain rhythms related to the speaker vs. listener roles during natural conversation. Nine dyads of healthy adults were recruited. The partners of a dyad were engaged in live conversations via an audio link while their brain activity was measured simultaneously in two separate MEG laboratories. The levels of ∼10-Hz and ∼20-Hz rolandic oscillations depended on the speaker vs. listener role. In the left rolandic cortex, these oscillations were consistently (by ∼20%) weaker during speaking than listening. At the turn changes in conversation, the level of the ∼10Hz oscillations enhanced transiently around 1.0 or 2.3s before the end of the partner's turn. Our findings indicate left-hemisphere-dominant involvement of the sensorimotor cortex during own speech in natural conversation. The ∼10-Hz modulations could be related to preparation for starting one's own turn, already before the partner's turn has finished.

  18. Acute functional reorganisation of the human motor cortex during resection of central lesions: a study using intraoperative brain mapping

    PubMed Central

    Duffau, H

    2001-01-01

    OBJECTIVES—Brain plasticity is supposed to allow the compensation of motor function in cases of rolandic lesion. The aim was to analyse the mechanisms of functional reorganisation during surgery in the central area.
METHODS—A motor brain mapping was performed in three right handed patients without any neurological deficit, operated on for a slow growing lesion near the rolandic region (two precentral resected under general anaesthesia and one retrocentral removed under local anaesthesia to allow also sensory mapping) using intraoperative direct electrical stimulations (5 mm space tips bipolar stimulator probe, biphasic square wave pulse current: 1 ms/phase, 60 Hz, 4 to 18mA).
RESULTS—For each patient, the motor areas of the hand and forearm in the primary motor cortex (M1) were identified before and after lesion removal with the same stimulation parameters: the same eloquent sites were found, plus the appearance after resection of additional sites in M1 inducing the same movement during stimulations as the previous areas.
CONCLUSIONS—Multiple cortical representations for hand and forearm movements in M1 seem to exist. In addition, the results demonstrate the short term capacity of the brain to make changes in local motor maps, by sudden unmasking after tumour resection of a second redundant site participating in the same movement. Finally, it seems not necessary for the whole of the redundant sites to be functional to provide normal movement, a concept with potential implications for surgery within the central region.

 PMID:11254775

  19. Imaging and Genetics of Language and Cognition in Pediatric Epilepsy

    PubMed Central

    Addis, Laura; Lin, Jack J.; Pal, Deb K.; Hermann, Bruce; Caplan, Rochelle

    2013-01-01

    This paper presents translational aspects of imaging and genetic studies of language and cognition in children with epilepsy of average intelligence. It also discusses current unanswered translational questions in each of these research areas. A brief review of multimodal imaging and language study findings shows that abnormal structure and function, as well as plasticity and reorganization in language-related cortical regions are found both in children with epilepsy with normal language skills and in those with linguistic deficits. The review on cognition highlights that multiple domains of impaired cognition and abnormalities in brain structure and/or connectivity are evident early on in childhood epilepsy and might be specific for epilepsy syndrome. The description of state of the art genetic analyses that can be used to explain the convergence of language impairment and Rolandic epilepsy includes a discussion of the methodological difficulties involved in these analyses. Two junior researchers describe how their current and planned studies address some of the unanswered translational questions regarding cognition and imaging and the genetic analysis of speech sound disorder, reading, and centrotemporal spikes in Rolandic epilepsy. PMID:23116771

  20. Prioritizing Rare Variants with Conditional Likelihood Ratios

    PubMed Central

    Li, Weili; Dobbins, Sara; Tomlinson, Ian; Houlston, Richard; Pal, Deb K.; Strug, Lisa J.

    2016-01-01

    Background Prioritizing individual rare variants within associated genes or regions often consists of an ad hoc combination of statistical and biological considerations. From the statistical perspective, rare variants are often ranked using Fisher’s exact p values, which can lead to different rankings of the same set of variants depending on whether 1- or 2-sided p values are used. Results We propose a likelihood ratio-based measure, maxLRc, for the statistical component of ranking rare variants under a case-control study design that avoids the hypothesis-testing paradigm. We prove analytically that the maxLRc is always well-defined, even when the data has zero cell counts in the 2×2 disease-variant table. Via simulation, we show that the maxLRc outperforms Fisher’s exact p values in most practical scenarios considered. Using next-generation sequence data from 27 rolandic epilepsy cases and 200 controls in a region previously shown to be linked to and associated with rolandic epilepsy, we demonstrate that rankings assigned by the maxLRc and exact p values can differ substantially. Conclusion The maxLRc provides reliable statistical prioritization of rare variants using only the observed data, avoiding the need to specify parameters associated with hypothesis testing that can result in ranking discrepancies across p value procedures; and it is applicable to common variant prioritization. PMID:25659987

  1. Conversion and the Real: The (Im)Possibility of Testimonial Representation.

    PubMed

    Sremac, Srdjan

    Although the spiritual vibration of conversion can be felt (by the curious outsider) through what conversion performers say in their testimonial discourse, what transforms the convert 'on stage' into a 'new being' and what is 'the real' (le réel) in conversion performance remain unclear. An important question in this connection is, What is 'real' in a conversion representation, both with respect to the convert's interaction with the audience and to the construction of social reality? Following Lacan's tripartite register of the imaginary, the symbolic, and the real, in this essay I argue that through testimonial discourse converts construct social reality as an answer to the impossibility of 'the real' in their performative discursive practice. In the first part, I question the constructed nature of testimonial representations-as well as some academic knowledge production that has governed conversion research in the last few decades-and how these representations encourage 'outsiders' to read the narrative repertoire as a negation or mirroring 'the real' of the conversion experience. In the second part, I apply Roland Barthes' analytic reflections on photography to conversion research, especially the notions of the studium (the common ground of cultural meanings) and the punctum (a personal experience that inspires private meaning). This brings me to a number of theorists (mostly never used in the field of religious conversion)-Jacques Lacan, Roland Barthes, and Slavoj Žižek-who are important to the perspective that is developed in this essay.

  2. Primary Care Physicians’ Action Plans for Responding to Results of Screening Tests Based on the Concept of Quaternary Prevention

    PubMed Central

    2016-01-01

    Since noncommunicable diseases (NCDs) are generally controllable rather than curable, more emphasis is placed on prevention than on treatment. For the early detection of diseases, primary care physicians (PCPs), as well as general practitioners and family physicians, should interpret screening results accurately and provide screenees with appropriate information about prevention and treatment, including potential harms. The concept of quaternary prevention (QP), which was introduced by Jamoulle and Roland in 1995, has been applied to screening results. This article summarizes situations that PCPs encounter during screening tests according to the concept of QP, and suggests measures to face such situations. It is suggested that screening tests be customized to fit individual characteristics instead of being performed based on general guidelines. Since screening tests should not be carried out in some circumstances, further studies based on the concept of prevention levels proposed by Jamoulle and Roland are required for the development of strategies to prevent NCDs, including cancers. Thus, applying the concept of QP helps PCPs gain better insights into screening tests aimed at preventing NCDs and also helps improve the doctor-patient relationship by helping screenees understand medical uncertainties. PMID:27951627

  3. Sensorimotor activation related to speaker vs. listener role during natural conversation

    PubMed Central

    Mandel, Anne; Bourguignon, Mathieu; Parkkonen, Lauri; Hari, Riitta

    2016-01-01

    Although the main function of speech is communication, the brain bases of speaking and listening are typically studied in single subjects, leaving unsettled how brain function supports interactive vocal exchange. Here we used whole-scalp magnetoencephalography (MEG) to monitor modulation of sensorimotor brain rhythms related to the speaker vs. listener roles during natural conversation. Nine dyads of healthy adults were recruited. The partners of a dyad were engaged in live conversations via an audio link while their brain activity was measured simultaneously in two separate MEG laboratories. The levels of ∼10-Hz and ∼20-Hz rolandic oscillations depended on the speaker vs. listener role. In the left rolandic cortex, these oscillations were consistently (by ∼20%) weaker during speaking than listening. At the turn changes in conversation, the level of the ∼10 Hz oscillations enhanced transiently around 1.0 or 2.3 s before the end of the partner’s turn. Our findings indicate left-hemisphere-dominant involvement of the sensorimotor cortex during own speech in natural conversation. The ∼10-Hz modulations could be related to preparation for starting one’s own turn, already before the partner’s turn has finished. PMID:26742643

  4. The threshold of cortical electrical stimulation for mapping sensory and motor functional areas.

    PubMed

    Guojun, Zhang; Duanyu, Ni; Fu, Paul; Lixin, Cai; Tao, Yu; Wei, Du; Liang, Qiao; Zhiwei, Ren

    2014-02-01

    This study aimed to investigate the threshold of cortical electrical stimulation (CES) for functional brain mapping during surgery for the treatment of rolandic epilepsy. A total of 21 patients with rolandic epilepsy who underwent surgical treatment at the Beijing Institute of Functional Neurosurgery between October 2006 and March 2008 were included in this study. Their clinical data were retrospectively collected and analyzed. The thresholds of CES for motor response, sensory response, and after discharge production along with other threshold-related factors were investigated. The thresholds (mean ± standard deviation) for motor response, sensory response, and after discharge production were 3.48 ± 0.87, 3.86 ± 1.31, and 4.84 ± 1.38 mA, respectively. The threshold for after discharge production was significantly higher than those of both the motor and sensory response (both p<0.05). A negative linear correlation was found between the threshold of after discharge production and disease duration. Using the CES parameters at a stimulation frequency of 50 Hz and a pulse width of 0.2 ms, the threshold of sensory and motor responses were similar, and the threshold of after discharge production was higher than that of sensory and motor response.

  5. Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain.

    PubMed

    Kivitz, Alan J; Gimbel, Joseph S; Bramson, Candace; Nemeth, Mary Anne; Keller, David S; Brown, Mark T; West, Christine R; Verburg, Kenneth M

    2013-07-01

    Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P⩽.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P⩽.05), and naproxen resulted in significant improvement of LBPI vs placebo (P⩽.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.

  6. Fungitoxic phenols from carnation (Dianthus caryophyllus) effective against Fusarium oxysporum f. sp. dianthi.

    PubMed

    Curir, Paolo; Dolci, Marcello; Dolci, Paola; Lanzotti, Virginia; De Cooman, Luc

    2003-01-01

    The phenol compositions of two cultivars of carnation (Dianthus caryophyllus) namely "Gloriana" and "Roland", which are partially and highly resistant, respectively, to Fusarium oxysporum f. sp. dianthi have been investigated with the aim of determining if endogenous phenols could have an anti-fungal effect against the pathogen. Analyses were performed on healthy and F. oxysporum-inoculated in vitro tissues, and on in vivo plants. Two benzoic acid derivatives, protocatechuic acid (3,4-dihydroxybenzoic acid) and vanillic acid (4-hydroxy-3-methoxybenzoic acid), were found within healthy and inoculated tissues of both cultivars, together with the flavonol glycoside peltatoside (3-[6-O-(alpha-L-arabinopyranosyl)-beta-D-glucopyranosyl] quercetin). These molecules proved to be only slightly inhibitory towards the pathogen. 2,6-Dimethoxybenzoic acid was detected in small amounts only in the inoculated cultivar "Gloriana", while the highly resistant cultivar "Roland" showed the presence of the flavone datiscetin (3,5,7,2'-tetrahydroxyflavone). The latter compound exhibited an appreciable fungitoxic activity towards F. oxysporum f. sp. dianthi.

  7. An fMRI study of obesity, food reward, and perceived caloric density. Does a low-fat label make food less appealing?

    PubMed

    Ng, Janet; Stice, Eric; Yokum, Sonja; Bohon, Cara

    2011-08-01

    We tested the hypothesis that obese individuals experience greater activation of the gustatory and somatosensory cortex, but weaker activation of the striatum, in response to intake and anticipated intake of high-fat chocolate milkshake versus an isocaloric milkshake labeled low-fat and a tasteless solution using functional magnetic resonance imaging (fMRI) with 17 obese and 17 lean young women. Obese relative to lean women showed greater activation in somatosensory (Rolandic operculum), gustatory (frontal operculum), and reward valuation regions (amgydala, ventralmedial prefrontal cortex (vmPFC) in response to intake and anticipated intake of milkshake versus tasteless solution, though there was little evidence of reduced striatal activation. Obese relative to lean women also showed greater activation in the Rolandic operculum, frontal operculum, and vmPFC in response to isocaloric milkshakes labeled regular versus low-fat. Results suggest that hyper-responsivity of somatosensory, gustatory, and reward valuation regions may be related to overeating and that top-down processing influence reward encoding, which could further contribute to weight gain.

  8. Educational studies of cosmic rays with a telescope of Geiger Müller counters

    NASA Astrophysics Data System (ADS)

    Wibig, T.; Kolodziejczak, K.; Pierzynski, R.; Sobczak, R.

    2006-11-01

    A group of high school students (XII Liceum) in the framework of the Roland Maze Project has built a compact telescope of three Geiger Müller counters. The connection between the telescope and a PC computer was also created and programmed by students involved in the Project. This has allowed students to use their equipment to perform serious scientific measurements concerning the single cosmic ray muon flux at ground level and below. These measurements were then analysed with the programs on the basis of current knowledge on statistics. An overview of the apparatus, methods and results have been presented at several student conferences and recently won the first prize in a national competition for high school students' scientific work. The telescope itself, in spite of its 'scientific' purposes, is built in such a way that it can be hung on a wall in a school physics lab and count muons continuously. This can help to raise in interest in studying physics among others. At present a few (three) groups of young participants of the Roland Maze Project have already built their own telescopes for their schools and some others are working on it. This work is a perfect example of what can be done by young people when respective opportunities are created by more experienced researchers and a little help and advice is given.

  9. [Effects of 3-hydroxypyridine and succinic acid derivates on the dynamics of vertebral/neurologic symptoms after the surgical treatment of disk herniations].

    PubMed

    Volchegorskiĭ, I A; Mester, K M

    2010-01-01

    A study of 3-hydroxypiridine and succinic acid derivates (emoxipin, reamberin and mexidol) effects on the 14 week dynamics of vertebral/neurologic symptoms was performed in 136 patients after the surgical treatment of disk herniations. Data obtained demonstrated the reduction of severity of neurodystrophic and radicular syndromes without significant changes in dorsalgia, psychological maladaptation (PM) and disability scores (DS) during 3.5 months in patients treated with emoxipin (150 mg i.v., daily) for two weeks after the microdiscectomy. The two-week administration of reamberin (400 mg i.v., daily) led to the early attenuation of neuropathic pain. The reduction of sings of radicular compression and DS measured with the Roland-Morris questionnaire were delayed for 3 months. Mexidol (300 mg i.v., once a day during two weeks) demonstrated the highest efficacy. This drug attenuated radicular and neurodystrophic syndromes, nociceptive and neuropathic pain, reduced PM and DS measured with both the Roland-Morris and the Oswestry questionnaires during 14 weeks after the surgery.

  10. Voxel-Wise Meta-Analysis of Gray Matter Changes in Amyotrophic Lateral Sclerosis

    PubMed Central

    Shen, Dongchao; Cui, Liying; Fang, Jia; Cui, Bo; Li, Dawei; Tai, Hongfei

    2016-01-01

    Background: Increasing neuroimaging studies have revealed gray matter (GM) anomalies of several brain regions by voxel-based morphometry (VBM) studies in patients with amyotrophic lateral sclerosis (ALS). A voxel-wise meta-analysis was conducted to integrate the reported studies to determine the consistent GM alterations in ALS based on VBM methods. Methods: Ovid Medline, Pubmed, Emabase, and BrainMap database were searched for relevant studies.Data were extracted by two independent researchers. Voxel-wise meta-analysis was performed using the effect-size signed differential mapping (ES-SDM) software. Results: Twenty-nine VBM studies comprising 638 subjects with ALS and 622 healthy controls (HCs) met inclusion criteria.The global GM volumes of ALS patients were significantly decreased compared with those of HCs. GM reductions in patients were mainly located in the right precentral gyrus, the left Rolandic operculum, the left lenticular nucleus and the right anterior cingulate/paracingulate gyri. The right precentral gyrus and the left inferior frontal gyrus might be potential anatomical biomarkers to evaluate the severity of the disease, and longer disease duration was associated with more GM atrophy in the left frontal aslant tract and the right precentral gyrus in ALS patients. Conclusion: The results support that ALS is a complex degenerative disease involving multisystems besides the motor system.The mechanism of asymmetric atrophy of the motor cortex and the implication of Rolandic operculum involvement in ALS need to be further elucidated in future studies. PMID:27065078

  11. Probing of structural relaxation times in the glassy state of sucrose and trehalose based on dynamical properties of two secondary relaxation processes

    SciTech Connect

    Kaminski, K.; Adrjanowicz, K.; Paluch, M.; Kaminska, E.

    2011-06-15

    Time-dependent isothermal dielectric measurements were carried out deeply in the glassy state on two very important saccharides: sucrose and trehalose. In both compounds two prominent secondary relaxation processes were identified. The faster one is an inherent feature of the whole family of carbohydrates. The slower one can also be detected in oligo- and polysaccharides. It was shown earlier that the {beta} process is the Johari-Goldstein (JG) relaxation coupled to motions of the glycosidic linkage, while the {gamma} relaxation originates from motions of the exocyclic hydroxymethyl unit. Recently, it was shown that the JG relaxation process can be used to determine structural relaxation times in the glassy state [R. Casalini and C. M. Roland, Phys. Rev. Lett. 102, 035701 (2009)]. In this paper we present the results of an analysis of the data obtained during aging using two independent approaches. The first was proposed by Casalini and Roland, and the second one is based on the variation of the dielectric strength of the secondary relaxation process during aging [J. K. Vij and G. Power, J. Non-Cryst. Solids 357, 783 (2011)]. Surprisingly, we found that the estimated structural relaxation times in the glassy state of both saccharides are almost the same, independent of the type of secondary mode. This finding calls into question the common view that secondary modes of intramolecular origin do not provide information about the dynamics of the glassy state.

  12. Comparison of epileptic and nonepileptic cases with centrotemporal spikes in view of clinical findings and electroencephalographic characteristics.

    PubMed

    Tombul, Temel; Anlar, Omer; Caksen, Hüseyin

    2006-03-01

    The morphological features of centrotemporal spike discharges (CTSD) and relationship of them with clinical diagnosis in cases with benign epilepsy of childhood with centrotemporal spikes (BECTS) and the other epileptic syndromes of childhood as well as some nonconvulsive neurological disorders were detected in the routine patient population who referred to the authors' EEG laboratory. Thirty-six cases (21 males, 15 females; 8 months-14 years old), in which awake and/or sleep EEGs revealed CTSD were included in this study. The cases were divided into two groups as epileptic and nonepileptic. The cases with seizure were divided into BECTS and the other epilepsies. Of the epileptic cases, 14 (38.8%) patients had typical rolandic seizures. In five cases, there were partial or secondary generalized seizures. Two cases had myoclonic seizures. In the nonepileptic group, there was mental retardation/behavioral disturbances in five cases; there were periodic syndromes of childhood such as migraine and equivalents of migraine in three cases; febrile convulsion in three cases, breath-holding spells in two cases, and primary enuresis nocturna in two cases. In the nonepileptic group, the discharges were significantly fewer than the other groups (p = .014). More frequent discharges occuring for shorter periods were more significantly observed in BECTS group (64%). Typically isolated spike and slow-waves in T3/T4 and C3/C4 location were significantly more common (86%) in rolandic epilepsy group (p = .01). The EEGs of cases with BECTS had more frequency in the cluster of discharges than the other groups (p = .018). Multifocal discharges were observed in 28.5% of cases with BECTS, in 20% of nonepileptic group, and in 71.4% of other epileptics in the trial. Although these epileptic and nonepileptic conditions have some differences in view of frequency and morphology and location, CTSDs could be manifested in the group without seizure. It was concluded that the similar focal

  13. Gain in Body Fat Is Associated with Increased Striatal Response to Palatable Food Cues, whereas Body Fat Stability Is Associated with Decreased Striatal Response

    PubMed Central

    Yokum, Sonja

    2016-01-01

    Cross-sectional brain-imaging studies reveal that obese versus lean humans show greater responsivity of reward and attention regions to palatable food cues, but lower responsivity of reward regions to palatable food receipt. However, these individual differences in responsivity may result from a period of overeating. We conducted a repeated-measures fMRI study to test whether healthy weight adolescent humans who gained body fat over a 2 or 3 year follow-up period show an increase in responsivity of reward and attention regions to a cue signaling impending milkshake receipt and a simultaneous decrease in responsivity of reward regions to milkshake receipt versus adolescents who showed stability of or loss of body fat. Adolescents who gained body fat, who largely remained in a healthy weight range, showed increases in activation in the putamen, mid-insula, Rolandic operculum, and precuneus to a cue signaling impending milkshake receipt versus those who showed stability of or loss of body fat, though these effects were partially driven by reductions in responsivity among the latter groups. Adolescents who gained body fat reported significantly greater milkshake wanting and milkshake pleasantness ratings at follow-up compared to those who lost body fat. Adolescents who gained body fat did not show a reduction in responsivity of reward regions to milkshake receipt or changes in responsivity to receipt and anticipated receipt of monetary reward. Data suggest that initiating a prolonged period of overeating may increase striatal responsivity to food cues, and that maintaining a balance between caloric intake and expenditure may reduce striatal, insular, and Rolandic operculum responsivity. SIGNIFICANCE STATEMENT This novel, repeated-measures brain-imaging study suggests that adolescents who gained body fat over our follow-up period experienced an increase in striatal responsivity to cues for palatable foods compared to those who showed stability of or loss of body fat

  14. Historical photogrammetry: Bird's Paluxy River dinosaur chase sequence digitally reconstructed as it was prior to excavation 70 years ago.

    PubMed

    Falkingham, Peter L; Bates, Karl T; Farlow, James O

    2014-01-01

    It is inevitable that some important specimens will become lost or damaged over time, conservation is therefore of vital importance. The Paluxy River dinosaur tracksite is among the most famous in the world. In 1940, Roland T. Bird described and excavated a portion of the site containing associated theropod and sauropod trackways. This excavated trackway was split up and housed in different institutions, and during the process a portion was lost or destroyed. We applied photogrammetric techniques to photographs taken by Bird over 70 years ago, before the trackway was removed, to digitally reconstruct the site as it was prior to excavation. The 3D digital model offers the opportunity to corroborate maps drawn by R.T. Bird when the tracksite was first described. More broadly, this work demonstrates the exciting potential for digitally recreating palaeontological, geological, or archaeological specimens that have been lost to science, but for which photographic documentation exists.

  15. Dyssynergia cerebellaris myoclonica (Ramsay Hunt syndrome): a condition unrelated to mitochondrial encephalomyopathies.

    PubMed Central

    Tassinari, C A; Michelucci, R; Genton, P; Pellissier, J F; Roger, J

    1989-01-01

    Thirteen patients with dyssynergia cerebellaris myoclonica (Ramsay Hunt syndrome) had full clinical and neurophysiological study as well as muscle biopsy. The patients had action myoclonus, generalised epileptic seizures, and mild cerebellar syndrome. The disease was inherited in an autosomal recessive pattern in five patients, and occurred as isolated cases in the remaining eight patients. The age at onset of symptoms ranged from 6 to 15 years (mean, 10.4 years). The EEG and polygraphic findings included normal background activity in most patients, spontaneous fast generalised spike-and-wave discharges, photosensitivity, no activation during slow sleep, and vertex and rolandic spikes in REM sleep. Results of muscle biopsy, performed an average of 14 years after onset of the disease, were normal and showed no mitochondrial abnormalities. These findings suggest that Ramsay Hunt syndrome is a condition with distinctive clinical and neurophysiological features and unrelated to mitochondrial encephalomyopathies. PMID:2703843

  16. International Program and Local Organizing Committees

    NASA Astrophysics Data System (ADS)

    2012-12-01

    International Program Committee Dionisio Bermejo (Spain) Roman Ciurylo (Poland) Elisabeth Dalimier (France) Alexander Devdariani (Russia) Milan S Dimitrijevic (Serbia) Robert Gamache (USA) Marco A Gigosos (Spain) Motoshi Goto (Japan) Magnus Gustafsson (Sweden) Jean-Michel Hartmann (France) Carlos Iglesias (USA) John Kielkopf (USA) John C Lewis (Canada) Valery Lisitsa (Russia) Eugene Oks (USA) Christian G Parigger (USA) Gillian Peach (UK) Adriana Predoi-Cross (Canada) Roland Stamm (Germany) Local Organizing Committee Nikolay G Skvortsov (Chair, St Petersburg State University) Evgenii B Aleksandrov (Ioffe Physico-Technical Institute, St Petersburg) Vadim A Alekseev (Scientific Secretary, St Petersburg State University) Sergey F Boureiko (St.Petersburg State University) Yury N Gnedin (Pulkovo Observatory, St Petersburg) Alexander Z Devdariani (Deputy Chair, St Petersburg State University) Alexander P Kouzov (Deputy Chair, St Petersburg State University) Nikolay A Timofeev (St Petersburg State University)

  17. ESA mission ROSETTA will probe for chirality of cometary amino acids.

    PubMed

    Thiemann, W H; Meierhenrich, U

    2001-01-01

    New crucial theoretical investigations on the origin of biomolecular chirality are reviewed briefly. With the goal to investigate these theories our team is going to perform the 'chirality-experiment' in the near future with cometary matter. In 2012 the robotical lander RoLand will detach from the orbiter of the ROSETTA spacecraft and set down on the surface of comet 46P/Wirtanen in order to separate and identify cometary organic compounds via GC-MS in situ. Chiral organics will be separated into their enantiomers by application of 3 capillary columns coated with different kinds of stationary phases. Non-volatile compounds like amino acids will be derivatized in especially developed gas phase alkylation steps avoiding reactions in the liquid phase. The results of these preliminary gas phase reactions are presented in this article.

  18. Position specificity in Chitonomyces (Ascomycota, Laboulbeniomycetes) on Laccophilus (Coleoptera, Dytiscidae): a molecular approach resolves a century-old debate.

    PubMed

    Goldmann, Lauren; Weir, Alex

    2012-01-01

    The occurrence of Laboulbeniomycete species consistently on a precise portion of beetle integument was investigated in 13 species of Chitonomyces ectoparasitic on the aquatic diving beetle Laccophilus maculosus (Coleoptera, Dytiscidae). The phenomenon was called "position specificity" by Roland Thaxter in 1896, yet the mechanism has remained unknown. By using molecular analysis of the nucSSU rRNA gene and the 5.8S and partial ITS1 rRNA regions, 13 species of Chitonomyces reported to exhibit position specificity on Laccophilus maculosus were placed neatly into pairs of morphotypes, resulting in synonomies and recognition of six phylogenetic species (one species is a triplet). Each phylogenetic species was located at corresponding positions on male and female beetles that make contact during mating. In addition, ecological data and video footage of the mating behaviors of Laccophilus confirmed that sexual transmission is the mechanism behind this enigmatic phenomenon.

  19. Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution.

    PubMed

    Villéga, Frédéric; Picard, Fabienne; Espil-Taris, Caroline; Husson, Marie; Michel, Véronique; Pedespan, Jean-Michel

    2011-06-01

    Benign nocturnal alternating hemiplegia (BNAH) of childhood is distinct from the classic form of malignant alternating hemiplegia of childhood [1]. It is characterized by hemiplegic attacks occurring exclusively during sleep [2]. It can be misdiagnosed as migraine, nocturnal frontal lobe epilepsy, benign rolandic epilepsy, Panayiotopoulos syndrome, or sleep-related movement disorder [1-4]. Only nine patients have been described to date, with typically, a normal development [1,5-7]. In order to insist about the benignity of the affection, we report two cases: a new three-year-old boy suffering from BNAH and a patient already published to show positive evolution at fourteen years of age. BNAH is a rare disorder but may be underdiagnosed. Making an early diagnosis can help to describe to the parents the good prognosis without treatment.

  20. Europäisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung

    NASA Astrophysics Data System (ADS)

    Jobst, Solvejg

    2005-11-01

    EUROPEAN CONSCIOUSNESS: TOWARDS DEFINING A COMPLEX CONCEPT AND ITS EDUCATIONAL SIGNIFICANCE - The present study aims at a definition of `European consciousness'. In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmüller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain identification structures and social perspectives, can take such distinct forms of moral consciousness as `Eurocentrism', `European patriotism', or `reflective European consciousness'. Making reference to Wolfgang Klafki's notion of general education, it is finally argued that the emancipatory contribution of schooling to greater European integration consists in mediating precisely this last way of thinking.

  1. Functional and structural balances of homologous sensorimotor regions in multiple sclerosis fatigue.

    PubMed

    Cogliati Dezza, I; Zito, G; Tomasevic, L; Filippi, M M; Ghazaryan, A; Porcaro, C; Squitti, R; Ventriglia, M; Lupoi, D; Tecchio, F

    2015-03-01

    Fatigue in multiple sclerosis (MS) is a highly disabling symptom. Among the central mechanisms behind it, an involvement of sensorimotor networks is clearly evident from structural and functional studies. We aimed at assessing whether functional/structural balances of homologous sensorimotor regions-known to be crucial for sensorimotor networks effectiveness-decrease with MS fatigue increase. Functional connectivity measures at rest and during a simple motor task (weak handgrip of either the right or left hand) were derived from primary sensorimotor areas electroencephalographic recordings in 27 mildly disabled MS patients. Structural MRI-derived inter-hemispheric asymmetries included the cortical thickness of Rolandic regions and the volume of thalami. Fatigue symptoms increased together with the functional inter-hemispheric imbalance of sensorimotor homologous areas activities at rest and during movement, in absence of any appreciable parenchymal asymmetries. This finding supports the development of compensative interventions that may revert these neuronal activity imbalances to relieve fatigue in MS.

  2. Airborne Wind Shear Detection and Warning Systems. Second Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Spady, Amos A., Jr. (Compiler); Bowles, Roland L. (Compiler); Schlickenmaier, Herbert (Compiler)

    1990-01-01

    The Second Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on October 18 to 20, 1988. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Herbrt Schlickenmaier of the FAA. The purpose of the meeting was to transfer significant, ongoing results gained during the second year of the joint NASA/FAA Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements.

  3. Airborne Wind Shear Detection and Warning Systems. Fourth Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Vicroy, Dan D. (Compiler); Bowles, Roland L. (Compiler); Passman, Robert H. (Compiler)

    1992-01-01

    The Fourth Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley Research Center (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on April 14-16, 1992. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Bob Passman of the FAA. The purpose of the meeting was to transfer significant ongoing results of the NASA/FAA Joint Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements. The present document has been compiled to record the essence of the technology updates and discussions which follow each.

  4. INDIAN CASTE SYSTEM: HISTORICAL AND PSYCHOANALYTIC VIEWS.

    PubMed

    Vallabhaneni, Madhusudana Rao

    2015-12-01

    This paper elucidates the historical origins and transformations of India's caste system. Surveying the complex developments over many centuries, it points out that three positions have been taken in this regard. One suggests that the caste one is born into can be transcended within one's lifetime by performing good deeds. The other declares caste to be immutable forever. And, the third says that one can be reborn into a higher caste if one lives a virtuous life. Moving on to the sociopolitical realm, the paper notes how these positions have been used and exploited. The paper then attempts to anchor the existence and purpose of the Hindu caste system in Freud's ideas about group psychology and Klein's proposals of splitting and projective identification. The paper also deploys the large group psychology concepts of Volkan and the culturally nuanced psychoanalytic anthropology of Roland and Kakar. It concludes with delineating some ameliorative strategies for this tragic problem in the otherwise robust democratic society of India.

  5. And to end on a poetic note: Galen's authorial strategies in the pharmacological books.

    PubMed

    Totelin, Laurence M V

    2012-06-01

    This paper examines the authorial strategies deployed by Galen in his two main pharmacological treatises devoted to compound remedies: Composition of Medicines according to Types and Composition of Medicines according to Places. Some of Galen's methods of self assertion (use of the first person; writing of prefaces) are conventional. Others have not received much attention from scholars. Thus, here, I examine Galen's borrowing of his sources' 'I'; his use of the phrase 'in these words'; and his recourse to Damocrates' verse to conclude pharmacological books. I argue that Galen's authorial persona is very different from that of the modern author as defined by Roland Barthes. Galen imitates and impersonates his pharmacological sources. This re-enactment becomes a way to gain experience (peira) of remedies and guarantees their efficacy.

  6. And to end on a poetic note: Galen’s authorial strategies in the pharmacological books

    PubMed Central

    Totelin, Laurence M.V.

    2012-01-01

    This paper examines the authorial strategies deployed by Galen in his two main pharmacological treatises devoted to compound remedies: Composition of Medicines according to Types and Composition of Medicines according to Places. Some of Galen’s methods of self assertion (use of the first person; writing of prefaces) are conventional. Others have not received much attention from scholars. Thus, here, I examine Galen’s borrowing of his sources’ ‘I’; his use of the phrase ‘in these words’; and his recourse to Damocrates’ verse to conclude pharmacological books. I argue that Galen’s authorial persona is very different from that of the modern author as defined by Roland Barthes. Galen imitates and impersonates his pharmacological sources. This re-enactment becomes a way to gain experience (peira) of remedies and guarantees their efficacy.

  7. An unusual neurological feature of HIV-1 encephalopathy: Gerstmann's syndrome.

    PubMed

    Cirelli, A; Ciardi, M; Salotti, A; Rossi, F

    1994-06-01

    The authors describe the first case in literature of Gerstmann's syndrome (agraphia, acalculia, finger agnosia) occurred in HIV correlated encephalopathy developed as the first severe manifestation of HIV infection in a patient with prevalent white matter neuroradiologic alterations. The PDL rapidly extended from the left subcortical parietal-occipital regions to the pre-rolandic one, with subsequent involvement of the corpus calosum splenium and the bilateral temporal lobes white matter. The authors indicate the extent of the lesions and the involvement of the interhemispheric connection fibres as the pathogenetic mechanism of the "Gerstmann syndrome", that until today has not been reported in the literature of the wide variety of AIDS dementia complex. The administration of 1 g of zidovudine for about 9 months did not avoid the establishing of the neurologic damage, but the sudden suspension of the drug could have enhanced the exacerbation of inflammation and the involvement of areas whose lesion is classically believed responsible for cognitive impairment.

  8. Session: Program Review X Wrap-Up

    SciTech Connect

    1992-01-01

    This wrap-up session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of Closing Remarks by Roland R. Kessler and six NGA Industry Critique Panel presentations: ''Summary of Comments on DOE-Industry Cooperation by Geothermal Industry Panel'' by James B. Koenig, GeothermEx, Inc.; ''NGA Industry Critique of the Exploration Component'' by Joe L. Iovenitti, Weiss Associates; ''Critique of Drilling Research'' by Jerry Hamblin, UNOCAL Geothermal; ''Critique Panel Comments on Reservoir Engineering, DOE Geothermal Technology Development'' by Dennis Kaspereit, California Energy Company, Inc.; ''DOE Geothermal Program Review - Critique on Production'' by Douglas B. Jung, Two-Phase Engineering and Research; ''Comments on the DOE Hydrothermal Energy Conversion R&D Program'' by David L. Mendive, Geothermal Development Associates.

  9. Opercular myoclonic-anarthric status epilepticus: A report of two cases

    PubMed Central

    Bhaskara Rao, Janapareddy Vijaya; Vengamma, Bhuma; Naveen, Thota; Rao, Marella Sudhakar

    2013-01-01

    Opercular myoclonic-anarthric status epilepticus (OMASE) is an uncommon disorder of diverse etiology. This condition is characterized by fluctuating cortical dysarthria associated with epileptic myoclonus involving glossopharyngeal musculature bilaterally. We report two cases of OMASE of vascular etiology in adults. In both patients, ictally clonic expression was consistent with epilepsia partialis continua and bilateral, symmetrical involvement of soft palate in one patient and tongue, lips, chin and inferior jaw in both patients due to bilateral projections of the inferior corticonuclear pathways. The inferior rolandic area of dominant and high frontal region in non-dominant hemispheres were involved by an epileptogenic lesion of vascular etiology, which was confirmed by magnetic resonance imaging of brain and single photon emission computerized tomography. Carotid Doppler study showed thrombosis of internal carotid artery in both patients, suggestive of an embolic origin. Early recognition of OMASE is important for early management of carotid occlusive disease. PMID:24339580

  10. Opercular myoclonic-anarthric status epilepticus: A report of two cases.

    PubMed

    Bhaskara Rao, Janapareddy Vijaya; Vengamma, Bhuma; Naveen, Thota; Rao, Marella Sudhakar

    2013-10-01

    Opercular myoclonic-anarthric status epilepticus (OMASE) is an uncommon disorder of diverse etiology. This condition is characterized by fluctuating cortical dysarthria associated with epileptic myoclonus involving glossopharyngeal musculature bilaterally. We report two cases of OMASE of vascular etiology in adults. In both patients, ictally clonic expression was consistent with epilepsia partialis continua and bilateral, symmetrical involvement of soft palate in one patient and tongue, lips, chin and inferior jaw in both patients due to bilateral projections of the inferior corticonuclear pathways. The inferior rolandic area of dominant and high frontal region in non-dominant hemispheres were involved by an epileptogenic lesion of vascular etiology, which was confirmed by magnetic resonance imaging of brain and single photon emission computerized tomography. Carotid Doppler study showed thrombosis of internal carotid artery in both patients, suggestive of an embolic origin. Early recognition of OMASE is important for early management of carotid occlusive disease.

  11. Clinical Impact of Epileptiform Discharge in Children With Attention-Deficit/Hyperactivity Disorder (ADHD).

    PubMed

    Lee, Eun Hye; Choi, Yong Sung; Yoon, Hoi Soo; Bahn, Geon Ho

    2016-04-01

    The aim of this study was to investigate the prevalence and clinical significance of epileptiform discharges in patients with attention-deficit/hyperactivity disorder (ADHD). The authors retrospectively reviewed 180 children who were diagnosed with ADHD and had an electroencephalography (EEG) recording. Epileptiform discharges were found in 29 (16.1%) of 180 patients with ADHD. Of these, 15 (8.3%) had generalized epileptiform discharges and 14 (7.7%) had focal epileptiform discharges. The focal epileptiform discharges were most prevalent from the frontal (5/14) and rolandic area (5/14). Among the 29 patients with epileptiform discharges and ADHD, 5 patients had previous history of epilepsy and 4 patients developed epilepsy later, whereas none of the normal EEG group developed epilepsy. The authors suggest that interictal epileptiform discharges appear to be associated with seizure occurrence in children with ADHD and might reflect maturational pathophysiology overlapping with epilepsy.

  12. Effects of a Home Exercise Program on the Self-report Disability Index and Gait Parameters in Patients with Lumbar Spinal Stenosis.

    PubMed

    Kim, Eui-Ryong; Kang, Min-Hyeok; Kim, Yang-Gon; Oh, Jae-Seop

    2014-02-01

    [Purpose] The present study was performed to identify the effect of a home exercise program on the self-reported disability index and gait parameters in patients with lumbar spinal stenosis (LSS). [Methods] Fifteen patients with LSS were enrolled in this study and were trained in a 4-week home exercise program (40 min/day). All patients were evaluated with three self-reported disability indices (Oswestry Disability Index, Roland-Morris Disability Questionnaire, and Spinal Stenosis Scale), and gait parameters were assessed using a GAITRite system before and after the home exercise program. [Results] Patients with LSS showed significant decreases in the self-reported questionnaire scores and pain intensity after the home exercise program. However, the gait parameters did not significantly change. [Conclusion] These findings suggest that home exercise programs can improve self-reported questionnaire scores and decrease pain in patients with LSS.

  13. Reduced fractional anisotropy in the anterior corpus callosum is associated with reduced speech fluency in persistent developmental stuttering.

    PubMed

    Civier, Oren; Kronfeld-Duenias, Vered; Amir, Ofer; Ezrati-Vinacour, Ruth; Ben-Shachar, Michal

    2015-04-01

    Developmental stuttering is a speech disorder that severely limits one's ability to communicate. White matter anomalies were reported in stuttering, but their functional significance is unclear. We analyzed the relation between white matter properties and speech fluency in adults who stutter (AWS). We used diffusion tensor imaging with tract-based spatial statistics, and examined group differences as well as correlations with behavioral fluency measures. We detected a region in the anterior corpus callosum with significantly lower fractional anisotropy in AWS relative to controls. Within the AWS group, reduced anisotropy in that region is associated with reduced fluency. A statistically significant interaction was found between group and age in two additional regions: the left Rolandic operculum and the left posterior corpus callosum. Our findings suggest that anterior callosal anomaly in stuttering may represent a maladaptive reduction in interhemispheric inhibition, possibly leading to a disadvantageous recruitment of right frontal cortex in speech production.

  14. Walthère Victor Spring - A Forerunner in the Study of the Greenhouse Effect

    NASA Astrophysics Data System (ADS)

    Demarée, Gaston R.; Verheyden, Rosiane

    2016-01-01

    In 1886, an article by Walthère Spring and Léon Roland, two scientists from the University of Liège, dealing with the carbon dioxide content in the atmosphere in Liège appeared in the "Mẻmoires" of the Royal Academy of Belgium. In order to explain the difference between temperatures in the city of Liège and those observed in that city's environs, the authors invoked the high level of atmospheric CO2. Although the climatological argument was rather weak and the article concerned only a local impact, it is obvious that Spring can be viewed as a precursor of Svante Arrhenius who foresaw global warming in 1895-1896.

  15. At Home in the Universe

    NASA Astrophysics Data System (ADS)

    Wheeler, John A.

    Colleague and confidant of Einstein and Bohr and pioneer of nuclear fission -- John A. Wheeler is one of our most original and profound thinkers. In engaging essays formed of reminiscence, science, and conjecture, Wheeler writes of debates and discussions with Bohr, long talks with Einstein in his study at Princeton, and the eloquence and nobility of Hermann Weyl. With simple delight in "the machinery of existence" Wheeler exudes an enthusiasm that illuminates this collection. John Wheeler is one of the 20th century's most notable nuclear physicists and relativity theorists. In addition, he has played a leading role in research on pulsars, black holes, and nuclear reactor safety. Dr. Wheeler is Jan and Roland Blumberg Professor Emeritus at the University of Texas, Austin and Joseph Henry Professor of Physics Emeritus at Princeton University.

  16. Biophysical approach to low back pain: a pilot report.

    PubMed

    Foletti, Alberto; Pokorný, Jiry

    2015-01-01

    Since biophysical treatment has been reported to be effective in the general management of pain, we decided to assess the specific effect and treatment duration of this therapeutic strategy in low back pain. We were interested in verifying the possibility that a single clinical procedure could reduce pain and improve patients' quality of life within a period of three months. An Electromagnetic Information Transfer Through Aqueous System was employed to record endogenous therapeutic signals from each individual using an electromagnetic recording device (Med Select 729). A highly significant reduction in the Roland Morris low back pain and disability questionnaire score was observed after 3 months following a single biophysical intervention (11.83 ± 6 at baseline versus 2.3 ± 3.25 at 3 months, p < 0.0001). This preliminary report provides further evidence of the theoretical implications and clinical applications of Quantum Electro Dynamic concepts in biology and medicine.

  17. The Effect of Topical Rosa damascena (Rose) Oil on Pregnancy-Related Low Back Pain: A Randomized Controlled Clinical Trial.

    PubMed

    Shirazi, Mahbobeh; Mohebitabar, Safieh; Bioos, Sodabeh; Yekaninejad, Mir Saeed; Rahimi, Roja; Shahpiri, Zahra; Malekshahi, Farhad; Nejatbakhsh, Fatemeh

    2017-01-01

    The study aimed to assess the efficacy of topical rose oil in women with pregnancy-related low back pain. A randomized controlled clinical trial was conducted on 120 women with pregnancy-related low back pain. Patients were allocated to 3 parallel groups to receive topical rose oil (in the carrier of almond oil), placebo (carrier oil), or no intervention. All groups were followed for 4 weeks. All participants were evaluated by Visual Analog Scale and the Roland-Morris Disability Questionnaires to assess the pain intensity and its impact on daily activities before and after the intervention. Significant decrease in pain intensity compared to carrier oil or no intervention was observed. The rose oil also improves the functional ability of these patients in contrast with no intervention, while its effect on function is not significant compared to carrier oil. Rose oil reduced pregnancy-related low back pain intensity without any significant adverse effect.

  18. Historical Photogrammetry: Bird's Paluxy River Dinosaur Chase Sequence Digitally Reconstructed as It Was prior to Excavation 70 Years Ago

    PubMed Central

    Falkingham, Peter L.; Bates, Karl T.; Farlow, James O.

    2014-01-01

    It is inevitable that some important specimens will become lost or damaged over time, conservation is therefore of vital importance. The Paluxy River dinosaur tracksite is among the most famous in the world. In 1940, Roland T. Bird described and excavated a portion of the site containing associated theropod and sauropod trackways. This excavated trackway was split up and housed in different institutions, and during the process a portion was lost or destroyed. We applied photogrammetric techniques to photographs taken by Bird over 70 years ago, before the trackway was removed, to digitally reconstruct the site as it was prior to excavation. The 3D digital model offers the opportunity to corroborate maps drawn by R.T. Bird when the tracksite was first described. More broadly, this work demonstrates the exciting potential for digitally recreating palaeontological, geological, or archaeological specimens that have been lost to science, but for which photographic documentation exists. PMID:24695537

  19. Cortical plasticity of motor-eloquent areas measured by navigated transcranial magnetic stimulation in patients with glioma.

    PubMed

    Conway, Neal; Wildschuetz, Noémie; Moser, Tobias; Bulubas, Lucia; Sollmann, Nico; Tanigawa, Noriko; Meyer, Bernhard; Krieg, Sandro M

    2017-01-20

    OBJECTIVE The goal of this study was to obtain a better understanding of the mechanisms underlying cerebral plasticity. Coupled with noninvasive detection of its occurrence, such an understanding has huge potential to improve glioma therapy. The authors aimed to demonstrate the frequency of plastic reshaping, find clues to the patterns behind it, and prove that it can be recognized noninvasively using navigated transcranial magnetic stimulation (nTMS). METHODS The authors used nTMS to map cortical motor representation in 22 patients with gliomas affecting the precentral gyrus, preoperatively and 3-42 months postoperatively. Location changes of the primary motor area, defined as hotspots and map centers of gravity, were measured. RESULTS Spatial normalization and analysis of hotspots showed an average shift of 5.1 ± 0.9 mm (mean ± SEM) on the mediolateral axis, and 10.7 ± 1.6 mm on the anteroposterior axis. Map centers of gravity were found to have shifted by 4.6 ± 0.8 mm on the mediolateral, and 8.7 ± 1.5 mm on the anteroposterior axis. Motor-eloquent points tended to shift toward the tumor by 4.5 ± 3.6 mm if the lesion was anterior to the rolandic region and by 2.6 ± 3.3 mm if it was located posterior to the rolandic region. Overall, 9 of 16 (56%) patients with high-grade glioma and 3 of 6 (50%) patients with low-grade glioma showed a functional shift > 10 mm at the cortical level. CONCLUSIONS Despite the small size of this series, analysis of these data showed that cortical functional reorganization occurs quite frequently. Moreover, nTMS was shown to detect such plastic reorganization noninvasively.

  20. Dilatancy Strengthening As a Mechanism for Earthquake Rupture Barriers and Aseismic Creep Transients on Oceanic Transform Faults

    NASA Astrophysics Data System (ADS)

    Liu, Y.; McGuire, J. J.; Behn, M. D.

    2014-12-01

    Ocean bottom seismometer deployments along the Gofar, Quebrada and Discovery transform faults on the East Pacific Rise (EPR) have revealed strong along-strike variation in M6 earthquake rupture extents and earthquake swarm activity. An active-source refraction survey along the ~ 100-km-long western segment of Gofar found a ~ 10-km-long zone of ~ 10-20% P wave velocity reduction, which extends from the surface to the Moho and acted as a "barrier" to previous cycles of M6 ruptures [McGuire et al., 2012; Roland et al., 2012]. The low velocity zone is interpreted to result primarily from enhanced fault zone porosity. That this region appears to behave as a rupture barrier is interesting from a fault frictional point of view because it nucleates intense microseismicity and hence has velocity-weakening (unstable slip) characteristics. In this study, we use a 3D strike-slip fault model with rate-state friction to investigate how the presence of a high-porosity, strong dilatancy zone embedded in a velocity-weakening transform fault could lead to a persistent earthquake rupture barrier. Rate-state frictional parameters are based on experimental results on gabbro gouge under hydrothermal conditions, and constrained by the tomoDD relocation of seismicity on Gofar [Froment et al., 2014]. Our modeling results reproduce the ~ 5 year recurrence interval of M6 earthquakes on two ~ 20-km-long fault segments separated by a ~ 10 km zone with effective dilatancy strengthening. A stronger dilatancy effect leads to a lower seismic coupling coefficient in the barrier zone. The release of energy in the barrier zone is manifested in various forms of aseismic deformation, including postseismic slip and interseismic slow slip events. The modeled slow slip migration speed and equivalent stress drop are comparable to those estimated from earthquake swarms on transform faults [Roland and McGuire, 2009], and suggests that such swarm activity is primarily driven by aseismic transient slip events.

  1. Determining the structural relaxation times deep in the glassy state of the pharmaceutical Telmisartan

    NASA Astrophysics Data System (ADS)

    Adrjanowicz, K.; Paluch, M.; Ngai, K. L.

    2010-03-01

    By using the dielectric relaxation method proposed recently by Casalini and Roland (2009 Phys. Rev. Lett. 102 035701), we were able to determine the structural α-relaxation times deep in the glassy state of the pharmaceutical, Telmisartan. Normally, deep in the glassy state τα is so long that it cannot be measured but τβ, which is usually much shorter, can be directly determined. The method basically takes advantage of the connection between the α-relaxation and the secondary β-relaxation of the Johari-Goldstein kind, including a relation between their relaxation times τα and τβ, respectively. Thus, τα of Telmisartan were determined by monitoring the change of the dielectric β-loss, ɛ'', with physical aging time at temperatures well below the vitrification temperature. The values of τα were compared with those expected by the coupling model (CM). Unequivocal comparison cannot be made in the case of Telmisartan because its β-loss peak is extremely broad, and the CM predicts only an order of magnitude agreement between the primitive relaxation frequency and the β-peak frequency. We also made an attempt to analyze all isothermal and aging susceptibility data after transformation into the electric modulus representation. The τα found in the glass state by using the method of Casalini and Roland in the modulus representation are similar to those obtained in the susceptibility representation. However, it is remarkable that the stretching parameter βKWW - M = 0.51 in the electric modulus representation gives more precise fits to the aging data than in the susceptibility representation with βKWW = 0.61. Our results suggest that the electric modulus representation may be useful as an alternative to analyze aging data, especially in the case of highly polar glassformers having a large ratio of low frequency and high frequency dielectric constants, such as the Telmisartan studied.

  2. Therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis.

    PubMed

    Takahashi, Naoto; Arai, Itaru; Kayama, Satoru; Ichiji, Kenji; Fukuda, Hironari; Kaga, Takahiro; Konno, Shin-Ichi

    2014-01-01

    The purpose of this study was to evaluate the therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis. Study subjects were classified into two groups according to their pharmacotherapy: the pregabalin group, treated with nonsteroidal anti-inflammatory drug and pregabalin combination therapy, and the control group, treated with nonsteroidal anti-inflammatory drug monotherapy. The two groups were compared in terms of the duration of pain after the onset of leg symptoms and the type of neurogenic intermittent claudication, whether radicular-, caudal-, or mixed-type. Numerical rating scale and Roland-Morris Disability Questionnaire scores were evaluated before and 3 months after treatment. After 3 months of treatment, there were significant differences in the numerical rating scale for radicular- and mixed-types, but not for caudal-type, between the two groups in the subjects with leg symptoms for greater than 3 months. There were significant differences between the two groups in Roland-Morris Disability Questionnaire scores for mixed-type, but not for radicular- and caudal-types, in the subjects with leg symptoms for less than 3 months and for radicular- and mixed-types, but not for caudal-type, in the subjects with leg symptoms for greater than 3 months. Nonsteroidal anti-inflammatory drug and pregabalin combination therapy may be more effective than nonsteroidal anti-inflammatory drug monotherapy for the relief of leg symptoms due to lumbar spinal stenosis, preventing aggravation of subjective symptoms and improving quality of life for patients with radicular- and mixed-types in subjects with leg symptoms for greater than 3 months, although it may be necessary to consider alternative therapy for patients with caudal-type.

  3. [EEG and ischemic stroke in full-term newborns].

    PubMed

    Selton, D; André, M; Hascoët, J M

    2003-06-01

    The aims of this study were to describe EEG anomalies in unilateral neonatal ischemic stroke without hypoxic-ischemic encephalopathy, and to determine possible links between these abnormalities and long-term outcome. In 6 full-term newborns without severe fetal distress ischemic stroke was confirmed by computed tomography and/or magnetic resonance imaging. Twenty EEGs were recorded during the neonatal period, 5 in acute stage and 15 later. The duration of the follow-up ranged from 3 to 9 years. All newborns developed unilateral clonic seizures, right-sided (5 cases) or left-sided (1 case); seizures began between 14 and 48 h of life. At follow-up, 3 children were normal at 2 and 6 years of age, while the 3 others had sequelae: epilepsy at 9 years of age in one, and unilateral mild cerebral palsy in the 2 others (3 and 4 years of age), with behavioral problems in one of them. Critical EEG discharges, rhythmic sharp waves and/or slow waves were recorded on the injured side. Abnormalities of interictal activity were excess of alpha or theta rhythms, transitory EEG discontinuity or low voltage. The 2 children with cerebral palsy had numerous unilateral post-ictal positive rolandic slow sharp waves (PRSSWs), which were similar to the positive rolandic sharp waves of premature infants; the child with behavioral problems had numerous positive left-sided temporal fast sharp waves. PRSSWs could be associated with contralateral motor sequelae, while positive left temporal fast sharp waves were associated with long term behavioral problems. These findings may be used for future prospective studies aimed at specifying the relation between EEG abnormalities and long-term outcome.

  4. The 27-item Coping Strategies Questionnaire – Revised: Confirmatory factor analysis, reliability and validity in Italian-speaking subjects with chronic pain

    PubMed Central

    Monticone, Marco; Ferrante, Simona; Giorgi, Ines; Galandra, Caterina; Rocca, Barbara; Foti, Calogero

    2014-01-01

    BACKGROUND: Increasing attention is being devoted to cognitive-behavioural measures to improve interventions for chronic pain. OBJECTIVE: To develop an Italian version of the Coping Strategies Questionnaire – Revised (CSQ-R), and to validate it in a study involving 345 Italian subjects with chronic pain. METHODS: The questionnaire was developed following international recommendations. The psychometric analyses included confirmatory factor analysis; reliability, assessed by internal consistency (Cronbach’s alpha) and test-retest reliability (intraclass correlation coefficients); and construct validity, assessed by calculating the correlations between the subscales of the CSQ-R and measures of pain (numerical rating scale), disability (Sickness Impact Profile – Roland Scale), depression (Center for Epidemiological Studies – Depression Scale) and coping (Chronic Pain Coping Inventory) (Pearson’s correlation). RESULTS: Confirmatory factor analysis revealed that the CSQ-R model had an acceptable data-model fit (comparative fit index and normed fit index ≤0.90, root mean square error of approximation ≥0.08). Cronbach’s alpha was satisfactory (CSQ-R 0.914 to 0.961), and the intraclass correlation coefficients were good/excellent (CSQ-R 0.850 to 0.918). As expected, the correlations with the numerical rating scale, Sickness Impact Profile – Roland Scale, Center for Epidemiological Studies – Depression Scale and Chronic Pain Coping Inventory highlighted the adaptive and maladaptive properties of most of the CSQ-R subscales. CONCLUSION: The CSQ-R was successfully translated into Italian. The translation proved to have good factorial structure, and its psychometric properties are similar to those of the original and other adapted versions. Its use is recommended for clinical and research purposes in Italy and abroad. PMID:24761430

  5. The usefulness of ICG video angiography in the surgical treatment of superior cluneal nerve entrapment neuropathy: technical note.

    PubMed

    Kim, Kyongsong; Isu, Toyohiko; Chiba, Yasuhiro; Morimoto, Daijiro; Ohtsubo, Seiji; Kusano, Mitsuo; Kobayashi, Shiro; Morita, Akio

    2013-11-01

    Superior cluneal nerve (SCN) entrapment neuropathy is a known cause of low back pain. Although surgical release at the entrapment point of the osteofibrous orifice is effective, intraoperative identification of the thin SCN in thick fat tissue and confirmation of sufficient decompression are difficult. Intraoperative indocyanine green video angiography (ICG-VA) is simple, clearly demonstrates the vascular flow dynamics, and provides real-time information on vascular patency and flow. The peripheral nerve is supplied from epineurial vessels around the nerve (vasa nervorum), and the authors now present the first ICG-VA documentation of the technique and usefulness of peripheral nerve neurolysis surgery to treat SCN entrapment neuropathy in 16 locally anesthetized patients. Clinical outcomes were assessed with the Roland-Morris Disability Questionnaire before surgery and at the latest follow-up after surgery. Indocyanine green video angiography was useful for identifying the SCN in fat tissue. It showed that the SCN penetrated and was entrapped by the thoracolumbar fascia through the orifice just before crossing over the iliac crest in all patients. The SCN was decompressed by dissection of the fascia from the orifice. Indocyanine green video angiography visualized the SCN and its termination at the entrapment point. After sufficient decompression, the SCN was clearly visualized on ICG-VA images. Low back pain improved significantly, from a preoperative Roland-Morris Questionnaire score of 13.8 to a postoperative score of 1.3 at the last follow-up visit (p < 0.05). The authors suggest that ICG-VA is useful for the inspection of peripheral nerves such as the SCN and helps to identify the SCN and to confirm sufficient decompression at surgery for SCN entrapment.

  6. Seventeenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1992-01-31

    PREFACE The Seventeenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 29-31, 1992. There were one hundred sixteen registered participants which equaled the attendance last year. Participants were from seven foreign countries: Italy, Japan, United Kingdom, France, Belgium, Mexico and New Zealand. Performance of many geothermal fields outside the United States was described in the papers. The Workshop Banquet Speaker was Dr. Raffaele Cataldi. Dr. Cataldi gave a talk on the highlights of his geothermal career. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Cataldi. Dr. Frank Miller presented the award at the banquet. Thirty-eight papers were presented at the Workshop with two papers submitted for publication only. Dr. Roland Horne opened the meeting and the key note speaker was J.E. ''Ted'' Mock who discussed the DOE Geothermal R. & D. Program. The talk focused on aiding long-term, cost effective private resource development. Technical papers were organized in twelve sessions concerning: geochemistry, hot dry rock, injection, geysers, modeling, and reservoir mechanics. Session chairmen were major contributors to the program and we thank: Sabodh Garg., Jim Lovekin, Jim Combs, Ben Barker, Marcel Lippmann, Glenn Horton, Steve Enedy, and John Counsil. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to Francois Groff who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook -vii

  7. Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex.

    PubMed

    Roll, Patrice; Vernes, Sonja C; Bruneau, Nadine; Cillario, Jennifer; Ponsole-Lenfant, Magali; Massacrier, Annick; Rudolf, Gabrielle; Khalife, Manal; Hirsch, Edouard; Fisher, Simon E; Szepetowski, Pierre

    2010-12-15

    It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental verbal dyspraxia, DVD), whereas mutations of sushi-repeat protein SRPX2 lead to epilepsy of the rolandic (sylvian) speech areas, with DVD or with bilateral perisylvian polymicrogyria. Pathophysiological mechanisms driven by SRPX2 involve modified interaction with the plasminogen activator receptor (uPAR). Independent chromatin-immunoprecipitation microarray screening has identified the uPAR gene promoter as a potential target site bound by FOXP2. Here, we directly tested for the existence of a transcriptional regulatory network between human FOXP2 and the SRPX2/uPAR complex. In silico searches followed by gel retardation assays identified specific efficient FOXP2-binding sites in each of the promoter regions of SRPX2 and uPAR. In FOXP2-transfected cells, significant decreases were observed in the amounts of both SRPX2 (43.6%) and uPAR (38.6%) native transcripts. Luciferase reporter assays demonstrated that FOXP2 expression yielded a marked inhibition of SRPX2 (80.2%) and uPAR (77.5%) promoter activity. A mutant FOXP2 that causes DVD (p.R553H) failed to bind to SRPX2 and uPAR target sites and showed impaired down-regulation of SRPX2 and uPAR promoter activity. In a patient with polymicrogyria of the left rolandic operculum, a novel FOXP2 mutation (p.M406T) was found in the leucine-zipper (dimerization) domain. p.M406T partially impaired the FOXP2 regulation of SRPX2 promoter activity, whereas that of the uPAR promoter remained unchanged. Together with recently described FOXP2-CNTNAP2 and SRPX2/uPAR links, the FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders.

  8. Patient Expectations as Predictors of Outcome In Patients with Acute Low Back Pain

    PubMed Central

    Phillips, Russell S.; Davis, Roger B.; Cherkin, Daniel C.; Legedza, Anna; Kaptchuk, Ted J.; Hrbek, Andrea; Buring, Julie E.; Post, Diana; Connelly, Maureen T.; Eisenberg, David M.

    2007-01-01

    BACKGROUND Few studies have evaluated the association between patient expectations for recovery and clinical outcomes, and no study has evaluated whether asking patients to choose their therapy modifies such an association. OBJECTIVE To evaluate the association between patients’ expectations and functional recovery in patients with acute low back pain (LBP), and to determine whether that association is affected by giving patients choice of therapy. DESIGN AND PARTICIPANTS A secondary analysis of a randomized controlled trial comparing usual care alone to usual care plus choice of chiropractic, acupuncture, or massage in 444 adults with acute LBP, lasting less than 21 days. MEASUREMENTS AND MAIN RESULTS Primary outcome was functional disability (Roland score) at 5 and 12 weeks. Patients’ general expectations for improvement were associated with improvement in functional status (β = 0.96, 95% CI = 0.56, 1.36). A 1-point increase in general expectations was associated with a 0.96-point improvement in Roland score. The association of expectation with outcome was 2–3 times greater in the usual care group than the choice group. However, these differences did not reach statistical significance. CONCLUSIONS In patients with acute LBP, higher expectations for recovery are associated with greater functional improvement. Eliciting patient expectations for improvement may be a simple way to identify patients with the highest (or lowest) likelihood of experiencing functional improvement. Incorporating questions about patient expectations in future trials may clarify the role of this important correlate of clinical outcomes. PMID:18066631

  9. Increasing Recreational Physical Activity in Patients With Chronic Low Back Pain: A Pragmatic Controlled Clinical Trial.

    PubMed

    Ben-Ami, Noa; Chodick, Gabriel; Mirovsky, Yigal; Pincus, Tamar; Shapiro, Yair

    2017-02-01

    Study Design Prospective, pragmatic, nonrandomized controlled clinical trial. Background Clinical guidelines recommend physical activity for the treatment of chronic low back pain. But engaging patients in physical activity has proven difficult. Known obstacles to physical activity include low self-efficacy and fear avoidance. Objectives This study tested the effectiveness of an enhanced transtheoretical model intervention (ETMI) aimed at increasing recreational physical activity in patients with chronic low back pain, in comparison to usual physical therapy. Methods Patients (n = 220) referred to physical therapy for chronic low back pain were allocated to ETMI or to a control group. The ETMI was delivered by physical therapists and based on behavior-change principles, combined with increased reassurance, therapeutic alliance, and exposure to reduce fear avoidance. The primary outcome was back pain-related disability (Roland-Morris Disability Questionnaire). Secondary outcomes included pain intensity, mental and physical health, and levels of physical activity. Results Intention-to-treat analysis in 189 patients at 12 months indicated that patients in the ETMI group had significantly lower disability compared to usual physical therapy. The difference in mean change from baseline between the interventions was 2.7 points (95% confidence interval: 0.9, 4.5) on the Roland-Morris Disability Questionnaire. At 12 months, worst pain, physical activity, and physical health were all significantly better in patients receiving ETMI. The average number of sessions was 3.5 for the ETMI group and 5.1 for controls. Conclusion Targeting obstacles to physical activity with an intervention that includes components to address self-efficacy and fear avoidance appears to be more effective than usual physical therapy care in reducing long-term disability. Further research is needed to explore the mechanisms that impact outcomes in this intervention package. Level of Evidence Therapy

  10. YOGA FOR CHRONIC LOW BACK PAIN IN A PREDOMINANTLY MINORITY POPULATION: A PILOT RANDOMIZED CONTROLLED TRIAL

    PubMed Central

    Saper, Robert B.; Sherman, Karen J.; Cullum-Dugan, Diana; Davis, Roger B.; Phillips, Russell S.; Culpepper, Larry

    2009-01-01

    Background Several studies suggest yoga may be effective for chronic low back pain; however, trials targeting minorities have not been conducted. Primary Study Objectives Assess the feasibility of studying yoga in a predominantly minority population with chronic low back pain. Collect preliminary data to plan a larger powered study. Study Design Pilot randomized controlled trial. Setting Two community health centers in a racially diverse neighborhood of Boston, Massachusetts. Participants Thirty English-speaking adults (mean age 44 years, 83% female, 83% racial/ethnic minorities; 48% with incomes ≤$30000) with moderate-to-severe chronic low back pain. Interventions Standardized series of weekly hatha yoga classes for 12 weeks compared to a waitlist usual care control. Outcome Measures Feasibility measured by time to complete enrollment, proportion of racial/ethnic minorities enrolled, retention rates, and adverse events. Primary efficacy outcomes were changes from baseline to 12 weeks in pain score (0=no pain to 10=worst possible pain) and back-related function using the modified Roland-Morris Disability Questionnaire (0–23 point scale, higher scores reflect poorer function). Secondary efficacy outcomes were analgesic use, global improvement, and quality of life (SF-36). Results Recruitment took 2 months. Retention rates were 97% at 12 weeks and 77% at 26 weeks. Mean pain scores for yoga decreased from baseline to 12 weeks (6.7 to 4.4) compared to usual care, which decreased from 7.5 to 7.1 (P=.02). Mean Roland scores for yoga decreased from 14.5 to 8.2 compared to usual care, which decreased from 16.1 to 12.5 (P=.28). At 12 weeks, yoga compared to usual care participants reported less analgesic use (13% vs 73%, P=.003), less opiate use (0% vs 33%, P=.04), and greater overall improvement (73% vs 27%, P=.03). There were no differences in SF-36 scores and no serious adverse events. Conclusion A yoga study intervention in a predominantly minority population with

  11. 3D model of radionuclide dispersion in coastal areas with multifraction cohesive and non-cohesive sediments

    NASA Astrophysics Data System (ADS)

    Brovchenko, Igor; Maderich, Vladimir; Jung, Kyung Tae

    2015-04-01

    We developed new radionuclide dispersion model that may be used in coastal areas, rivers and estuaries with non-uniform distribution of suspended and bed sediments both cohesive and non-cohesive types. Model describes radionuclides concentration in dissolved phase in water column, particulated phase on suspended sediments on each sediment class types, bed sediments and pore water. The transfer of activity between the water column and the pore water in the upper layer of the bottom sediment is governed by diffusion processes. The phase exchange between dissolved and particulate radionuclides is written in terms of desorption rate a12 (s-1) and distribution coefficient Kd,iw and Kd,ib (m3/kg) for water column and for bottom deposit, respectively. Following (Periáñez et al., 1996) the dependence of distribution coefficients is inversely proportional to the sediment particle size. For simulation of 3D circulation, turbulent diffusion and wave fields a hydrostatic model SELFE (Roland et. al. 2010) that solves Reynolds-stress averaged Navier-Stokes (RANS) equations and Wave Action transport equation on the unstructured grids was used. Simulation of suspended sediment concentration and bed sediments composition is based on (L. Pinto et. al., 2012) approach that originally was developed for non-cohesive sediments. In present study we modified this approach to include possibility of simulating mixture of cohesive and non-cohesive sediments by implementing parameterizations for erosion and deposition fluxes for cohesive sediments and by implementing flocculation model for determining settling velocity of cohesive flocs. Model of sediment transport was calibrated on measurements in the Yellow Sea which is shallow tidal basin with strongly non-uniform distribution of suspended and bed sediments. Model of radionuclide dispersion was verified on measurements of 137Cs concentration in surface water and bed sediments after Fukushima Daiichi nuclear accident. References Peri

  12. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life.

    PubMed

    Ranieri, M; Sciuscio, M; Cortese, A M; Santamato, A; Di Teo, L; Ianieri, G; Bellomo, R G; Stasi, M; Megna, M

    2009-01-01

    The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) and the beneficial effect of physical exercise on positive sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict. Often these painful syndromes after the acute event, tend to recurr becoming subacute or chronic syndromes that become for the period of interest disabiling is an event very important in these cases proper prevention, based on a maintenance drug therapy and the strengthening exercises of paravertebral muscles, flexibility exercises on the spine and when needed on the reduction of body weight. In this Observational Cohort, two-arm trial, 203 patients were enrolled and divided into two groups, the first, ALA and GLA group, (n = 101) received oral dose of 600 mg of alpha-lipoic acid (ALA) and 360 mg of gamma-linolenic acid (GLA) and a rehabilitation program for six weeks, the second (n = 102) treated with only rehabilitation program. Patients were recruited at the centre of Physical Medicine and Rehabilitation, they underwent a physiatric examination at the primary outcome (t0) and secondary outcomes were recorded at monitoring visits scheduled at two weeks = t1, four weeks = t2, six weeks = t3, and at the same has been administered the following scale: VAS scale, SF-36, Oswestry Low Back Pain Disability Questionnaire, Aberdeen Back Pain Scale (ABPS), Revised Leeds Disability Questionnaire (LDQ), Roland and Morris Disability Questionnaire. Significant improvements was noted in the ALA and GLA group for paresthesia, stabbing and burning pain, as showed by VAS (Visual Analogue Scale), Oswestry Low Back Pain Disability Questionnaire, Aberdeen Low Back Pain Scale; also, improvements of quality of life has been noted, in the same group, as showed by SF-36, LDQ (Revised Leeds Disability Questionnaire), Roland and Morris disability questionnaire. All these outcome measure showed statistically

  13. Sixteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1991-01-25

    The Sixteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 23-25, 1991. The Workshop Banquet Speaker was Dr. Mohinder Gulati of UNOCAL Geothermal. Dr. Gulati gave an inspiring talk on the impact of numerical simulation on development of geothermal energy both in The Geysers and the Philippines. Dr. Gulati was the first recipient of The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy. Dr. Frank Miller presented the award. The registered attendance figure of one hundred fifteen participants was up slightly from last year. There were seven foreign countries represented: Iceland, Italy, Philippines, Kenya, the United Kingdom, Mexico, and Japan. As last year, papers on about a dozen geothermal fields outside the United States were presented. There were thirty-six papers presented at the Workshop, and two papers were submitted for publication only. Attendees were welcomed by Dr. Khalid Aziz, Chairman of the Petroleum Engineering Department at Stanford. Opening remarks were presented by Dr. Roland Horne, followed by a discussion of the California Energy Commission's Geothermal Activities by Barbara Crowley, Vice Chairman; and J.E. ''Ted'' Mock's presentation of the DOE Geothermal Program: New Emphasis on Industrial Participation. Technical papers were organized in twelve sessions concerning: hot dry rock, geochemistry, tracer injection, field performance, modeling, and chemistry/gas. As in previous workshops, session chairpersons made major contributions to the program. Special thanks are due to Joel Renner, Jeff Tester, Jim Combs, Kathy Enedy, Elwood Baldwin, Sabodh Garg, Marcel0 Lippman, John Counsil, and Eduardo Iglesias. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Angharad Jones, Rosalee Benelli, Jeanne Mankinen, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes

  14. Randomized, Double-blind, Placebo-controlled Phase III Trial of Duloxetine Monotherapy in Japanese Patients With Chronic Low Back Pain

    PubMed Central

    Konno, Shinichi; Oda, Natsuko; Ochiai, Toshimitsu; Alev, Levent

    2016-01-01

    Study Design. A 14-week, randomized, double-blind, multicenter, placebo-controlled study of Japanese patients with chronic low back pain (CLBP) who were randomized to either duloxetine 60 mg once daily or placebo. Objective. This study aimed to assess the efficacy and safety of duloxetine monotherapy in Japanese patients with CLBP. Summary of Background Data. In Japan, duloxetine is approved for the treatment of depression, diabetic neuropathic pain, and pain associated with fibromyalgia; however, no clinical study of duloxetine has been conducted for CLBP. Methods. The primary efficacy measure was the change in the Brief Pain Inventory (BPI) average pain score from baseline to Week 14. Secondary efficacy measures included BPI pain (worst pain, least pain, pain right now), Patient's Global Impression of Improvement, Clinical Global Impressions of Severity, and Roland-Morris Disability Questionnaire, among other measures, and safety and tolerability. Results. In total, 458 patients were randomized to receive either duloxetine (n = 232) or placebo (n = 226). The BPI average pain score improved significantly in the duloxetine group compared with that in the placebo group at Week 14 [−2.43 ± 0.11 vs. −1.96 ± 0.11, respectively; between-group difference (95% confidence interval), − 0.46 [−0.77 to−0.16]; P = 0.0026]. The duloxetine group showed significant improvement in many secondary measures compared with the placebo group, including BPI pain (least pain, pain right now) (between-group difference: −1.69 ± 0.10, P = 0.0009; −2.42 ± 0.12, P P = 0.0230, respectively), Patient's Global Impression of Improvement (2.46 ± 0.07, P = 0.0026), Clinical Global Impressions of Severity (−1.46 ± 0.06, P = 0.0019), and Roland-Morris Disability Questionnaire (−3.86 ± 0.22, P = 0.0439). Adverse events occurring at a significantly higher incidence in the duloxetine group were somnolence

  15. Effect of Stratified Care for Low Back Pain in Family Practice (IMPaCT Back): A Prospective Population-Based Sequential Comparison

    PubMed Central

    Foster, Nadine E.; Mullis, Ricky; Hill, Jonathan C.; Lewis, Martyn; Whitehurst, David G. T.; Doyle, Carol; Konstantinou, Kika; Main, Chris; Somerville, Simon; Sowden, Gail; Wathall, Simon; Young, Julie; Hay, Elaine M.

    2014-01-01

    PURPOSE We aimed to determine the effects of implementing risk-stratified care for low back pain in family practice on physician’s clinical behavior, patient outcomes, and costs. METHODS The IMPaCT Back Study (IMplementation to improve Patient Care through Targeted treatment) prospectively compared separate patient cohorts in a preintervention phase (6 months of usual care) and a postintervention phase (12 months of stratified care) in family practice, involving 64 family physicians and linked physical therapy services. A total of 1,647 adults with low back pain were invited to participate. Stratified care entailed use of a risk stratification tool to classify patients into groups at low, medium, or high risk for persistent disability and provision of risk-matched treatment. The primary outcome was 6-month change in disability as assessed with the Roland-Morris Disability Questionnaire. Process outcomes captured physician behavior change in risk-appropriate referral to physical therapy, diagnostic tests, medication prescriptions, and sickness certifications. A cost-utility analysis estimated incremental quality-adjusted life-years and back-related health care costs. Analysis was by intention to treat. RESULTS The 922 patients studied (368 in the preintervention phase and 554 in the postintervention phase) had comparable baseline characteristics. At 6 months follow-up, stratified care had a small but significant benefit relative to usual care as seen from a mean difference in Roland-Morris Disability Questionnaire scores of 0.7 (95% CI, 0.1–1.4), with a large, clinically important difference in the high risk group of 2.3 (95% CI, 0.8–3.9). Mean time off work was 50% shorter (4 vs 8 days, P = .03) and the proportion of patients given sickness certifications was 30% lower (9% vs 15%, P = .03) in the postintervention cohort. Health care cost savings were also observed. CONCLUSIONS Stratified care for back pain implemented in family practice leads to significant

  16. Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex

    PubMed Central

    Roll, Patrice; Vernes, Sonja C.; Bruneau, Nadine; Cillario, Jennifer; Ponsole-Lenfant, Magali; Massacrier, Annick; Rudolf, Gabrielle; Khalife, Manal; Hirsch, Edouard; Fisher, Simon E.; Szepetowski, Pierre

    2010-01-01

    It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental verbal dyspraxia, DVD), whereas mutations of sushi-repeat protein SRPX2 lead to epilepsy of the rolandic (sylvian) speech areas, with DVD or with bilateral perisylvian polymicrogyria. Pathophysiological mechanisms driven by SRPX2 involve modified interaction with the plasminogen activator receptor (uPAR). Independent chromatin-immunoprecipitation microarray screening has identified the uPAR gene promoter as a potential target site bound by FOXP2. Here, we directly tested for the existence of a transcriptional regulatory network between human FOXP2 and the SRPX2/uPAR complex. In silico searches followed by gel retardation assays identified specific efficient FOXP2-binding sites in each of the promoter regions of SRPX2 and uPAR. In FOXP2-transfected cells, significant decreases were observed in the amounts of both SRPX2 (43.6%) and uPAR (38.6%) native transcripts. Luciferase reporter assays demonstrated that FOXP2 expression yielded a marked inhibition of SRPX2 (80.2%) and uPAR (77.5%) promoter activity. A mutant FOXP2 that causes DVD (p.R553H) failed to bind to SRPX2 and uPAR target sites and showed impaired down-regulation of SRPX2 and uPAR promoter activity. In a patient with polymicrogyria of the left rolandic operculum, a novel FOXP2 mutation (p.M406T) was found in the leucine-zipper (dimerization) domain. p.M406T partially impaired the FOXP2 regulation of SRPX2 promoter activity, whereas that of the uPAR promoter remained unchanged. Together with recently described FOXP2-CNTNAP2 and SRPX2/uPAR links, the FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders. PMID:20858596

  17. Nineteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W.

    1994-01-20

    PREFACE The Nineteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 18-20, 1994. This workshop opened on a sad note because of the death of Prof. Henry J. Ramey, Jr. on November 19, 1993. Hank had been fighting leukemia for a long time and finally lost the battle. Many of the workshop participants were present for the celebration of his life on January 21 at Stanford's Memorial Church. Hank was one of the founders of the Stanford Geothermal Program and the Geothermal Reservoir Engineering Workshop. His energy, kindness, quick wit, and knowledge will long be missed at future workshops. Following the Preface we have included a copy of the Memorial Resolution passed by the Stanford University Senate. There were one hundred and four registered participants. Participants were from ten foreign countries: Costa Rica, England, Iceland, Italy, Japan, Kenya, Mexico, New Zealand, Philippines and Turkey. Workshop papers described the performance of fourteen geothermal fields outside the United States. Roland N. Home opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a presentation about the future of geothermal development. The banquet speaker was Jesus Rivera and he spoke about Energy Sources of Central American Countries. Forty two papers were presented at the Workshop. Technical papers were organized in twelve sessions concerning: sciences, injection, production, modeling, and adsorption. Session chairmen are an important part of the workshop and our thanks go to: John Counsil, Mark Walters, Dave Duchane, David Faulder, Gudmundur Bodvarsson, Jim Lovekin, Joel Renner, and Iraj Ershaghi. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual

  18. Quark Matter 2011 (QM11) Quark Matter 2011 (QM11)

    NASA Astrophysics Data System (ADS)

    2011-12-01

    International Advisory Committee Antinori, FedericoPaic, Guy Braun-Munzinger, PeterPajares, Carlos Cifarelli, LuisaPeitzmann, Thomas Erazmus, BarbaraRedlich, Krzysztof Eskola, KariRiccati, Lodovico Gaardhøje, Jens JørgenRoland, Gunther Gale, CharlesRoy, Christelle Gelis, FrancoisSchukraft, Jürgen Giubellino, PaoloSinha, Bikash Greiner, CarstenSrivastava, Dinesh Gyulassy, MiklosStachel, Johanna Harris, JohnSteinberg, Peter Hatsuda, TetsuoStroth, Joachim Heinz, UlrichSugitate, Toru Jacak, BarbaraTserruya, Itzhak Karsch, FrithjofVelkovska, Julia Kharzeev, DimaWang, Enke Kodama, TakeshiWang, Xin, Nian Lévai, PéterWessels, Johannes Manko, VladislavXu, Nu Müller, BerndtZajc, William Ollitrault, Jean-Yves Organizing Committee Arleo, FrancoisDupieux, Pascal Bastid, NicoleFurget, Christophe Bourgeois, Marie-LaureGranier de Cassagnac, Raphael Bregant, MarcoGuernane, Rachid Carminati, FedericoHervet, Carnita Castillo, JavierKuhn, Christian Cheynis, BrigitteOlivier, Nathalie Conesa, DelValle, Zaida Connor, MichelleRenshall, Lucy Crochet, PhilippeSuire, Christophe Delagrange, HuguesTihinen, Ulla Program Committee Schutz, Yves (Chair)Baldisseri, Alberto Wiedemann, Urs (co-Chair)Safarik, Karel Aurenche, Patrick

  19. Framing the ultimatum game: the contribution of simulation.

    PubMed

    Tomasino, Barbara; Lotto, Lorella; Sarlo, Michela; Civai, Claudia; Rumiati, Rino; Rumiati, Raffaella I

    2013-01-01

    It has now become widely accepted that economic decisions are influenced by cognitive and emotional processes. In the present study, we aimed at disentangling the neural mechanisms associated with the way in which the information is formulated, i.e., framing effect, in terms of gain or loss, which influences people's decisions. Participants played a fMRI version of the Ultimatum Game (UG) where we manipulated bids through two different frames: the expression "I give you" (gain) focusing on money the respondent would receive if she/he agreed with the proponent, and the expression "I take" (loss) focusing on the money that would be removed from the respondent in the event that she/he accepted the offer. Neuroimaging data revealed a frame by response interaction, showing an increase of neural activity in the right rolandic operculum/insular cortex, the anterior cingulate, among other regions, for accepting the frame "I take" vs. rejecting, as compared to accepting the frame "I give you" vs. rejecting. In addition, the left occipito-temporal junction was activated for "I take" vs. "I give you" for offer 5, corresponding to the equal offer made unpleasant by the presence of the frame "I take," where is the proposer that takes the money. Our data extend the current understanding of the neural substrates of social decision making, by disentangling the structures sensitive to the way in which the information is formulated (i.e., framing effect), in terms of gain or loss.

  20. Comparison between Kinesio Taping and a Traditional Physical Therapy Program in Treatment of Nonspecific Low Back Pain

    PubMed Central

    Kachanathu, Shaji John; Alenazi, Aqeel M.; Seif, Hamada Eid; Hafez, Ashraf Ramadan; Alroumim, Meshari Abdulmohsen

    2014-01-01

    [Purpose] Nonspecific low back pain (NSLBP) is a very common but largely self-limiting condition. Several types of tape and their associated application methods are available for different conditions. The aim of the present study was to observe the effect of Kinesio taping (KT) compared with traditional management of NSLBP. [Subjects and Methods] Forty male and female patients with a mean age of 34.8±7.54 years were randomly divided into two groups; group 1 (n=20) which underwent conventional physical therapy with KT, and group 2 (n=20), which underwent only conventional physical therapy. The intervention sessions for both groups were three times per week for four weeks. Outcomes were assessed for activities of daily living (ADL) using the Roland-Morris Disability Questionnaire, pain severity using a visual analogue scale, and ranges of motion (ROMs) of trunk flexion and extension using the modified Schober’s test. [Results] Significant differences in measures of pain, ADL, and trunk flexion and extension ROMs were observed post intervention within each group. In comparison, there were no significant differences in measures of pain, ADL, and trunk flexion and extension ROMs post intervention between groups. [Conclusion] A physical therapy program involving strengthening exercises for abdominal muscles and stretching exercises for back, hamstring, and iliopsoas muscles with or without Kinesio taping was beneficial in the treatment of chronic low back pain. PMID:25202177

  1. Therapeutic efficacy of nonsteroidal anti-inflammatory drug therapy versus exercise therapy in patients with chronic nonspecific low back pain: a prospective study.

    PubMed

    Takahashi, Naoto; Omata, Jun-Ichi; Iwabuchi, Masumi; Fukuda, Hironari; Shirado, Osamu

    2017-03-22

    Therapy for chronic, nonspecific low back pain is mainly conservative: medication and/or exercise. Pharmacotherapy, however, has side effects, and the quantities of concomitant drugs in older persons require attention. Although exercise promises improved function, its use to alleviate pain is controversial. Thus, we compared the efficacy of pharmacotherapy versus exercise for treating chronic nonspecific low back pain. The pharmacotherapy group (n=18: 8 men, 10 women) were prescribed celecoxib monotherapy. The exercise group (n=22: 10 men, 12 women) undertook stretching exercises. Because of drop-outs, the NSAID group (n=15: 7 men, 8 women) and the exercise group (n =18: 8 men, 10 women) were finally analyzed. We applied a visual analog scale, Roland-Morris disability scores, and the 36-Item Short Form Health Survey. We used a paired t-test for within-group analyses and an unpaired t-test for between-group analyses. Pain relief was achieved after 3 months of pharmacotherapy or exercise. Quality of life improved only in the exercise group. Recovery outcomes for the two groups were not significantly different. Efficacy of exercise therapy for strictly defined low back pain was almost equivalent to that of pharmacotherapy and provided better quality of life.

  2. Relativistic Astrophysics

    NASA Astrophysics Data System (ADS)

    Jones, Bernard J. T.; Markovic, Dragoljub

    1997-06-01

    Preface; Prologue: Conference overview Bernard Carr; Part I. The Universe At Large and Very Large Redshifts: 2. The size and age of the Universe Gustav A. Tammann; 3. Active galaxies at large redshifts Malcolm S. Longair; 4. Observational cosmology with the cosmic microwave background George F. Smoot; 5. Future prospects in measuring the CMB power spectrum Philip M. Lubin; 6. Inflationary cosmology Michael S. Turner; 7. The signature of the Universe Bernard J. T. Jones; 8. Theory of large-scale structure Sergei F. Shandarin; 9. The origin of matter in the universe Lev A. Kofman; 10. New guises for cold-dark matter suspects Edward W. Kolb; Part II. Physics and Astrophysics Of Relativistic Compact Objects: 11. On the unification of gravitational and inertial forces Donald Lynden-Bell; 12. Internal structure of astrophysical black holes Werner Israel; 13. Black hole entropy: external facade and internal reality Valery Frolov; 14. Accretion disks around black holes Marek A. Abramowicz; 15. Black hole X-ray transients J. Craig Wheeler; 16. X-rays and gamma rays from active galactic nuclei Roland Svensson; 17. Gamma-ray bursts: a challenge to relativistic astrophysics Martin Rees; 18. Probing black holes and other exotic objects with gravitational waves Kip Thorne; Epilogue: the past and future of relativistic astrophysics Igor D. Novikov; I. D. Novikov's scientific papers and books.

  3. Motor features in posterior cortical atrophy and their imaging correlates☆

    PubMed Central

    Ryan, Natalie S.; Shakespeare, Timothy J.; Lehmann, Manja; Keihaninejad, Shiva; Nicholas, Jennifer M.; Leung, Kelvin K.; Fox, Nick C.; Crutch, Sebastian J.

    2014-01-01

    Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by impaired higher visual processing skills; however, motor features more commonly associated with corticobasal syndrome may also occur. We investigated the frequency and clinical characteristics of motor features in 44 PCA patients and, with 30 controls, conducted voxel-based morphometry, cortical thickness, and subcortical volumetric analyses of their magnetic resonance imaging. Prominent limb rigidity was used to define a PCA-motor subgroup. A total of 30% (13) had PCA-motor; all demonstrating asymmetrical left upper limb rigidity. Limb apraxia was more frequent and asymmetrical in PCA-motor, as was myoclonus. Tremor and alien limb phenomena only occurred in this subgroup. The subgroups did not differ in neuropsychological test performance or apolipoprotein E4 allele frequency. Greater asymmetry of atrophy occurred in PCA-motor, particularly involving right frontoparietal and peri-rolandic cortices, putamen, and thalamus. The 9 patients (including 4 PCA-motor) with pathology or cerebrospinal fluid all showed evidence of Alzheimer's disease. Our data suggest that PCA patients with motor features have greater atrophy of contralateral sensorimotor areas but are still likely to have underlying Alzheimer's disease. PMID:25086839

  4. Cerebral gray matter volume variation in female-to-male transsexuals: a voxel-based morphometric study.

    PubMed

    Kim, Tae-Hoon; Kim, Seok-Kwun; Jeong, Gwang-Woo

    2015-12-16

    Several studies seem to support the hypothesis that brain anatomy is associated with transsexualism. However, these studies were still limited because few neuroanatomical findings have been obtained from female-to-male (FtM) transsexuals. This study compared the cerebral regional volumes of gray matter (GM) between FtM transsexuals and female controls using a voxel-based morphometry. Twelve FtM transsexuals who had undergone sex-reassignment surgery and 15 female controls participated in this study. Both groups were age matched and right-handed, with no history of neurological illness. Fifteen female controls were recruited to determine whether GM volumes in FtM transsexuals more closely resembled individuals who shared their biological sex. MRI data were processed using SPM 8 with the diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL). FtM transsexuals showed significantly larger volumes of the thalamus, hypothalamus, midbrain, gyrus rectus, head of caudate nucleus, precentral gyrus, and subcallosal area compared with the female controls. However, the female controls showed a significantly larger volume in the superior temporal gyrus including Heschl's gyrus and Rolandic operculum. These findings confirm that the volume difference in brain substructures in FtM transsexuals is likely to be associated with transsexualism and that transsexualism is probably associated with distinct cerebral structures, determining gender identity.

  5. Brain maturation and epilepsy.

    PubMed

    Dulac, Olivier; Milh, Mathieu; Holmes, Gregory L

    2013-01-01

    At full term, both glutamate and gamma-amino-butyric acid (GABA) are excitatory; cortical synapses are beginning to appear, there is little myelin in the cerebral hemispheres, and long tracts hardly start to develop. Neonatal myoclonic encephalopathy can result from premature activation of N-methyl-D-aspartate (NMDA) transmission. Benign neonatal seizures and migrating partial seizures in infancy could involve excessive or premature excitability of deep cortical layers. Benign rolandic epilepsy and continuous spike waves in slow sleep are consistent with an excess of both excitatory and inhibitory cortical synapses. West and Lennox-Gastaut syndromes express age-related diffuse cortical hyperexcitability, the pattern depending on the age of occurrence; synchronization of spikes is becoming possible with maturation of the myelin. Idiopathic generalized epilepsy is itself modulated by maturation that causes frontal hyperexcitability generating myoclonic-astatic seizures, between the ages of infantile and juvenile myoclonic epilepsies. Physiological delay of hippocampo-neocortical pathways maturation could account for the delayed occurrence of mesial temporal epilepsy following infantile damage, whereas premature maturation could contribute to fronto-temporal damage characteristic of fever-induced epileptic encephalopathy in school-age children, a dramatic school-age epileptic encephalopathy.

  6. [Complicities and ambivalences of psychiatry: Münsterlingen and the 1954 feast of fools].

    PubMed

    Basso, Elisabetta

    2017-01-01

    In March 1954, Foucault visited the psychiatric asylum of Münsterlingen (Canton Thurgau), on the Swiss side of Lake Constance. Münsterlingen was the chosen place of activity for well-known psychiatrists, including Hermann Rorschach (1910-1913), and it became famous in the history of psychiatry especially through the work of Roland Kuhn, who was active in the asylum from 1939 to 1979. Kuhn was an expert in the Rorschach psycho-diagnostic test, as well as the discoverer of the first antidepressant in the early 1950s. He was also very close to Ludwig Binswanger, whose anthropological approach to mental illness had a strong influence on his own psychiatric practice. It is precisely in order to meet Kuhn and Binswanger that the young Foucault went to Switzerland, at a time when he was interested in philosophical anthropology and "existential psychopathology". Foucault's visit took place during the Carnival at the asylum, when the patients leave the hospital wearing the masks that they have made up and created.

  7. Frontal hemispheric differences in the Bereitschaftspotential associated with writing and drawing.

    PubMed

    Schreiber, H; Lang, M; Lang, W; Kornhuber, A; Heise, B; Keidel, M; Deecke, L; Kornhuber, H H

    1983-01-01

    Twenty right-handed subjects participated in a study investigating the cerebral potentials related to three complex actions: (1) writing one's own signature, (2) drawing a pentagram, and (3) fast meaningless scribbling. The Bereitschaftspotential (BP, readiness potential) started as early as 3 s prior to writing, 2.5 s prior to drawing, but only 1.5 s prior to scribbling. In all three tasks, the BP had its earliest onset over the supplementary motor area (SMA). BP topography was shifted towards the frontal lobes when compared to encephalographic activity reflecting simple finger movements, and was very weak in retro-rolandic leads. The side of the performing hand, as assessed from scribbling, was reflected in a contralateral preponderance of the precentral BP. The maximum BP (about 6 microV) was, in all three tasks, located in FCz (mid fronto-central) overlying the SMA. This location is different from that for simple finger movements, when the maximum is at the vertex. Hemispheric differences were found over the frontal cortex and were characteristic for the verbal and spatial tasks involved: for writing, the BP was significantly larger left frontally than right (even after considering the effect of the performing hand from scribbling), and the difference was largest prior to the onset of movement; for drawing, the BP was larger over the right than over the left frontal lobe, and the difference was largest during the movement.

  8. Intact brain processing of musical emotions in autism spectrum disorder, but more cognitive load and arousal in happy vs. sad music

    PubMed Central

    Gebauer, Line; Skewes, Joshua; Westphael, Gitte; Heaton, Pamela; Vuust, Peter

    2014-01-01

    Music is a potent source for eliciting emotions, but not everybody experience emotions in the same way. Individuals with autism spectrum disorder (ASD) show difficulties with social and emotional cognition. Impairments in emotion recognition are widely studied in ASD, and have been associated with atypical brain activation in response to emotional expressions in faces and speech. Whether these impairments and atypical brain responses generalize to other domains, such as emotional processing of music, is less clear. Using functional magnetic resonance imaging, we investigated neural correlates of emotion recognition in music in high-functioning adults with ASD and neurotypical adults. Both groups engaged similar neural networks during processing of emotional music, and individuals with ASD rated emotional music comparable to the group of neurotypical individuals. However, in the ASD group, increased activity in response to happy compared to sad music was observed in dorsolateral prefrontal regions and in the rolandic operculum/insula, and we propose that this reflects increased cognitive processing and physiological arousal in response to emotional musical stimuli in this group. PMID:25076869

  9. The Effects of VR-based Wii Fit Yoga on Physical Function in Middle-aged Female LBP Patients.

    PubMed

    Kim, Seong-Sik; Min, Won-Kyu; Kim, Jung-Hee; Lee, Byoung-Hee

    2014-04-01

    [Purpose] The purpose of this research was to determine the effects of a virtual reality-based yoga program on middle-aged female low back pain patients. [Subjects and Methods] Thirty middle-aged female patients who suffered from low back pain were assigned to either a physical therapy program or a virtual reality-based yoga program for a period of four weeks. Participants could check their posture and weight bearing on a monitor as they shifted their weight or changed their postures on a Wii balance board. There were a total of seven exercise programs. A 30-minute, three times per week, virtual reality-based Wii Fit yoga program or trunk stabilizing exercise was performed, respectively. [Results] Repeated-measures analysis of covariance revealed significant differences in between pre- and post-training VAS, algometer, Oswestry low-back pain disability index (ODI), Roland Morris disability questionnaire (RMDQ), and fear avoidance beliefs questionnaire (FBQ) scores. The VAS, algometer, ODI, RMDQ, and FBQ scores showed significant differences in groups. Regarding the effect of time-by-group interaction, there were significant differences in VAS, ODI, ODI, and FBQ scores. [Conclusion] In conclusion, for middle-aged female patients who have low back pain, a virtual reality-based yoga program was shown to have positive effects on physical improvements, and this program can be employed as a therapeutic medium for prevention and cure of low back pain.

  10. Mediators of yoga and stretching for chronic low back pain.

    PubMed

    Sherman, Karen J; Wellman, Robert D; Cook, Andrea J; Cherkin, Daniel C; Ceballos, Rachel M

    2013-01-01

    Although yoga is an effective treatment for chronic low back pain, little is known about the mechanisms responsible for its benefits. In a trial comparing yoga to intensive stretching and self-care, we explored whether physical (hours of back exercise/week), cognitive (fear avoidance, body awareness, and self-efficacy), affective (psychological distress, perceived stress, positive states of mind, and sleep), and physiological factors (cortisol, DHEA) mediated the effects of yoga or stretching on back-related dysfunction (Roland-Morris Disability Scale (RDQ)). For yoga, 36% of the effect on 12-week RDQ was mediated by increased self-efficacy, 18% by sleep disturbance, 9% by hours of back exercise, and 61% by the best combination of all possible mediators (6 mediators). For stretching, 23% of the effect was mediated by increased self-efficacy, 14% by days of back exercise, and 50% by the best combination of all possible mediators (7 mediators). In open-ended questions, ≥20% of participants noted the following treatment benefits: learning new exercises (both groups), relaxation, increased awareness, and the benefits of breathing (yoga), benefits of regular practice (stretching). Although both self-efficacy and hours of back exercise were the strongest mediators for each intervention, compared to self-care, qualitative data suggest that they may exert their benefits through partially distinct mechanisms.

  11. Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study.

    PubMed

    Stice, Eric; Spoor, Sonja; Bohon, Cara; Veldhuizen, Marga G; Small, Dana M

    2008-11-01

    The authors tested the hypothesis that obese individuals experience greater reward from food consumption (consummatory food reward) and anticipated consumption (anticipatory food reward) than lean individuals using functional magnetic resonance imaging (fMRI) with 33 adolescent girls (mean age = 15.7, SD = 0.9). Obese relative to lean adolescent girls showed greater activation bilaterally in the gustatory cortex (anterior and mid insula, frontal operculum) and in somatosensory regions (parietal operculum and Rolandic operculum) in response to anticipated intake of chocolate milkshake (vs. a tasteless solution) and to actual consumption of milkshake (vs. a tasteless solution); these brain regions encode the sensory and hedonic aspects of food. However, obese relative to lean adolescent girls also showed decreased activation in the caudate nucleus in response to consumption of milkshake versus a tasteless solution, potentially because they have reduced dopamine receptor availability. Results suggest that individuals who show greater activation in the gustatory cortex and somatosensory regions in response to anticipation and consumption of food, but who show weaker activation in the striatum during food intake, may be at risk for overeating and consequent weight gain.

  12. Can a self-administered questionnaire identify workers with chronic or recurring low back pain?

    PubMed

    Takekawa, Karina Satiko; Gonçalves, Josiane Sotrate; Moriguchi, Cristiane Shinohara; Coury, Helenice Jane Cote Gil; Sato, Tatiana de Oliveira

    2015-01-01

    To verify if the Nordic Musculoskeletal Questionnaire (NMQ), Visual Analogue Scale (VAS), Roland-Morris Disability Questionnaire (RDQ) and physical examination of the lumbar spine can identify workers with chronic or recurring low back pain, using health history for reference. Fifty office workers of both sexes, aged between 19 and 55 yr, were evaluated using a standardized physical examination and the NMQ, VAS and RDQ. Discriminant analysis was performed to determine the discriminant properties of these instruments. A higher success rate (94%) was observed in the model including only the NMQ and in the model including the NMQ and the physical examination. The lowest success rate (82%) was observed in the model including the NMQ, RDQ and VAS. The NMQ was able to detect subjects with chronic or recurring low back pain with 100% sensitivity and 88% specificity. The NMQ appears to be the best instrument for identifying subjects with chronic or recurring low back pain. Thus, this self-reported questionnaire is suitable for screening workers for chronic or recurring low back pain in occupational settings.

  13. Intact brain processing of musical emotions in autism spectrum disorder, but more cognitive load and arousal in happy vs. sad music.

    PubMed

    Gebauer, Line; Skewes, Joshua; Westphael, Gitte; Heaton, Pamela; Vuust, Peter

    2014-01-01

    Music is a potent source for eliciting emotions, but not everybody experience emotions in the same way. Individuals with autism spectrum disorder (ASD) show difficulties with social and emotional cognition. Impairments in emotion recognition are widely studied in ASD, and have been associated with atypical brain activation in response to emotional expressions in faces and speech. Whether these impairments and atypical brain responses generalize to other domains, such as emotional processing of music, is less clear. Using functional magnetic resonance imaging, we investigated neural correlates of emotion recognition in music in high-functioning adults with ASD and neurotypical adults. Both groups engaged similar neural networks during processing of emotional music, and individuals with ASD rated emotional music comparable to the group of neurotypical individuals. However, in the ASD group, increased activity in response to happy compared to sad music was observed in dorsolateral prefrontal regions and in the rolandic operculum/insula, and we propose that this reflects increased cognitive processing and physiological arousal in response to emotional musical stimuli in this group.

  14. Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia - a prospective, randomised, double-blind study.

    PubMed

    Thomas, E; Cyteval, C; Abiad, L; Picot, M C; Taourel, P; Blotman, F

    2003-10-01

    A prospective, randomised, double-blind study was carried out to compare the respective efficacies of transforaminal and interspinous epidural corticosteroid injections in discal radiculalgia. Thirty-one patients (18 females, 13 males) with discal radicular pain of less than 3 months' duration were consecutively randomised to receive either radio-guided transforaminal or blindly performed interspinous epidural corticosteroid injections. Post-treatment outcome was evaluated clinically at 6 and 30 days, and then at 6 months, but only by mailed questionnaire. At day 6, the between-group difference was significantly in favour of the transforaminal group with respect to Schober's index, finger-to-floor distance, daily activities, and work and leisure activities on the Dallas pain scale. At day 30, pain relief was significantly better in the transforaminal group. At month 6, answers to the mailed questionnaire still showed significantly better results for transforaminal injection concerning pain, daily activities, work and leisure activities and anxiety and depression, with a decline in the Roland-Morris score. In recent discal radiculalgia, the efficacy of radio-guided transforaminal epidural corticosteroid injections was higher than that obtained with blindly-performed interspinous injections.

  15. Nonsurgical Korean Integrative Treatments for Symptomatic Lumbar Spinal Stenosis: A Three-Armed Randomized Controlled Pilot Trial Protocol

    PubMed Central

    Kim, Kiok; Shin, Kyung-Min; Lee, Jun-Hwan; Seo, Bok-Nam; Jung, So-Young; Youn, Yousuk; Lee, Sang Ho; Kim, Jaehong; Qu, Wenchun

    2016-01-01

    This is a study protocol for a pilot three-armed randomized controlled trial on nonsurgical integrative Korean medicinal treatment for symptomatic lumbar spinal stenosis (LSS). Thirty-six participants who have been diagnosed with (LSS) and recommended for spinal surgery by neurosurgeons or orthopedics and have had spinal symptoms such as severe low back pain and neurological claudication regardless of at least three months of conservative treatments will be recruited. Participants will be randomly assigned to be one of the three intervention groups, including the Mokhuri treatment program group 1 or 2 or usual care group. All treatments will be administered in inpatient units over a period of 4 weeks. The primary outcomes are 0 to 100 Visual Analogue Scales for low back pain and leg pain and the secondary outcomes are Oswestry Disability Index; EQ-5D; Roland-Morris Disability Questionnaire; Oxford Claudication Score; physical function test, including treadmill test, walking duration, and distance assessment for free leg pain; radiologic testing; and adverse events which will be assessed during the 4-week treatment period as well as after 3 and 6 months of follow-up. Then, we will assess the feasibility of the clinical trial design as well as a nonsurgical integrative treatment program. This trial is registered with CRIS registration number: KCT0001218. PMID:26941823

  16. The five factors of personality and regional cortical variability in the Baltimore longitudinal study of aging.

    PubMed

    Kapogiannis, Dimitrios; Sutin, Angelina; Davatzikos, Christos; Costa, Paul; Resnick, Susan

    2013-11-01

    Although personality changes have been associated with brain lesions and atrophy caused by neurodegenerative diseases and aging, neuroanatomical correlates of personality in healthy individuals and their stability over time have received relatively little investigation. In this study, we explored regional gray matter (GM) volumetric associations of the five-factor model of personality. Eighty-seven healthy older adults took the NEO Personality Inventory and had brain MRI at two time points 2 years apart. We performed GM segmentation followed by regional analysis of volumes examined in normalized space map creation and voxel based morphometry-type statistical inference in SPM8. We created a regression model including all five factors and important covariates. Next, a conjunction analysis identified associations between personality scores and GM volumes that were replicable across time, also using cluster-level Family-Wise-Error correction. Larger right orbitofrontal and dorsolateral prefrontal cortices and rolandic operculum were associated with lower Neuroticism; larger left temporal, dorsolateral prefrontal, and anterior cingulate cortices with higher Extraversion; larger right frontopolar and smaller orbitofrontal and insular cortices with higher Openness; larger right orbitofrontal cortex with higher Agreeableness; larger dorsolateral prefrontal and smaller frontopolar cortices with higher Conscientiousness. In summary, distinct personality traits were associated with stable individual differences in GM volumes. As expected for higher-order traits, regions performing a large number of cognitive and affective functions were implicated. Our findings highlight personality-related variation that may be related to individual differences in brain structure that merit additional attention in neuroimaging research.

  17. Mediators of Yoga and Stretching for Chronic Low Back Pain

    PubMed Central

    Sherman, Karen J.; Wellman, Robert D.; Cook, Andrea J.; Cherkin, Daniel C.; Ceballos, Rachel M.

    2013-01-01

    Although yoga is an effective treatment for chronic low back pain, little is known about the mechanisms responsible for its benefits. In a trial comparing yoga to intensive stretching and self-care, we explored whether physical (hours of back exercise/week), cognitive (fear avoidance, body awareness, and self-efficacy), affective (psychological distress, perceived stress, positive states of mind, and sleep), and physiological factors (cortisol, DHEA) mediated the effects of yoga or stretching on back-related dysfunction (Roland-Morris Disability Scale (RDQ)). For yoga, 36% of the effect on 12-week RDQ was mediated by increased self-efficacy, 18% by sleep disturbance, 9% by hours of back exercise, and 61% by the best combination of all possible mediators (6 mediators). For stretching, 23% of the effect was mediated by increased self-efficacy, 14% by days of back exercise, and 50% by the best combination of all possible mediators (7 mediators). In open-ended questions, ≥20% of participants noted the following treatment benefits: learning new exercises (both groups), relaxation, increased awareness, and the benefits of breathing (yoga), benefits of regular practice (stretching). Although both self-efficacy and hours of back exercise were the strongest mediators for each intervention, compared to self-care, qualitative data suggest that they may exert their benefits through partially distinct mechanisms. PMID:23690832

  18. Twentieth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    1995-01-26

    PREFACE The Twentieth Workshop on Geothermal Reservoir Engineering, dedicated to the memory of Professor Hank Ramey, was held at Stanford University on January 24-26, 1995. There were ninety-five registered participants. Participants came from six foreign countries: Japan, Mexico, England, Italy, New Zealand and Iceland. The performance of many geothermal reservoirs outside the United States was described in several of the papers. Professor Roland N. Horne opened the meeting and welcomed visitors to the campus. The key note speaker was Marshall Reed, who gave a brief overview of the Department of Energy's current plan. Thirty-two papers were presented in the technical sessions of the workshop. Technical papers were organized into eleven sessions concerning: field development, modeling, well tesubore, injection, geoscience, geochemistry and field operations. Session chairmen were major contributors to the workshop, and we thank: Ben Barker, Bob Fournier, Mark Walters, John Counsil, Marcelo Lippmann, Keshav Goyal, Joel Renner and Mike Shook. In addition to the technical sessions, a panel discussion was held on ''What have we learned in 20 years?'' Panel speakers included Patrick Muffler, George Frye, Alfred Truesdell and John Pritchett. The subject was further discussed by Subir Sanyal, who gave the post-dinner speech at the banquet. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank our students who operated the audiovisual equipment. Shaun D. Fitzgerald Program Manager

  19. Retrospective on 30 years of nonimaging optics development for solar energy at the University of Chicago

    NASA Astrophysics Data System (ADS)

    O'Gallagher, Joseph J.

    2016-09-01

    As the field of nonimaging optics has developed over the last 50 years, among its many applications, the best known and recognized is probably in solar energy. In particular, the approach provides the formalism that allows the design of devices that approach the maximum physically attainable geometric concentration for a given set of optical tolerances. This means that it has the potential to revolutionize the design of solar concentrators. Much of the experimental development and early testing of these concepts was carried out at the University of Chicago by Roland Winston and his colleagues and students. In this presentation, some of many embodiments and variations of the basic Compound Parabolic Concentrator that were developed and tested over a thirty-year period at Chicago are reviewed. Practical and economic aspects of concentrator design for both thermal and photovoltaic applications are discussed. Examples covering the whole range of concentrator applications from simple low-concentration non-tracking designs to ultrahigh-concentration multistage configurations are covered.

  20. When Is EEG Indicated in Attention-Deficit/Hyperactivity Disorder?

    PubMed

    Zaimoğlu, Sennur; Türkdoğan, Dilşad; Mazlum, Betül; Bekiroğlu, Nural; Tetik-Kabil, Aylin; Eyilikeder, Seda

    2015-11-01

    The authors investigated the parameters for predicting epileptiform abnormalities in a group of children diagnosed with attention-deficit/hyperactivity disorder (ADHD). The sample consisted of 148 subjects aged between 6 and 13 (8.76 ± 1.26; 25.7% female) years. Subtypes of ADHD and comorbid psychiatric disorders were defined according to DSM-IV criteria. The Wechsler Intelligence Scale for Children-Revised was applied to all patients. Most of the subjects (89.2%) had wakefulness and sleep electroencephalography examinations lasting about one hour. The authors found out that the coexistence of speech sound disorder (odds ratio [OR] 3.90, 95% confidence interval [CI]: 1.61-9.48) and higher Digit Span test performance (OR 1.24, 95% CI: 1.06-1.44) predicted the presence of accompanying epileptiform abnormalities. The prevalence of epileptiform abnormalities was 26.4%, and they were frequently localized in the frontal (41%) and centrotemporal (28.2%) regions. Higher percentage of speech sound disorder co-occurrence (64%) in subjects with rolandic spikes suggests that epileptiform abnormalities associated with ADHD can be determined genetically at least in some cases. Pathophysiology of epileptiform abnormalities in ADHD might have complex genetic and maturational background.

  1. On the nature of the anti-tail of Comet Kohoutek /1973f/. II - Comparison of the working model with ground-based photographic observations

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.; Miller, F. D.

    1976-01-01

    On the basis of photographic observations made at the Cerro Tololo Inter-American Observatory, the radial and transverse brightness profiles and time variations in the surface brightness of the anti-tail of Comet Kohoutek were examined. In the process of photometric reduction one-dimensional radial tracings passing through the comet's nucleus and covering the entire anti-tail were used in the place of the standard two-dimensional scans. Each radial scan was defined by the position angle, and 'noise' variations were interpolated from the known field brightness outside the anti-tail. An analysis of the results provides quantitative support for a previously proposed model (Sekanina, 1974) suggesting that the dust particles in the anti-tail suffered a significant loss in radius due to evaporation near the perihelion passage. Preliminary calculations indicate that only particles initially larger than 100-150 micrometers in diameter survived. The emission rate of dust may be comparable to those derived for Comets Arend-Roland (1957 III) and Bennett (1970 II).

  2. Brain activity associated with skilled finger movements: multichannel magnetic recordings.

    PubMed

    Chiarenza, G A; Hari, R K; Karhu, J J; Tessore, S

    1991-01-01

    We recorded with a 24-channel SQUID magnetometer cerebral activity preceding and following self-paced voluntary 'skilled' movements in four healthy adults. The subject pressed buttons successively with the right index and middle fingers aiming at a time difference of 40-60 ms; on-line feedback on performance was given after each movement. Slow magnetic readiness fields (RFs) preceded the movements by 0.5 s and culminated about 20 ms after the electromyogram (EMG) onset. Movement-evoked fields, MEFs, opposite in polarity to RFs, were observed 90-120 ms after the EMG onset. They were followed by an additional 'skilled-performance field', SPF, 400-500 ms after the EMG onset. The source locations of RF, MEF, and SPF were within 2 cm from sources of the somatosensory evoked responses, which were situated in the posterior wall of the Rolandic fissure; the sources of MEF were closest to the midline. Neural generators of these deflections and of the corresponding electric potentials are discussed.

  3. Effect of an exercise programme for the prevention of back and neck pain in poultry slaughterhouse workers.

    PubMed

    Bertozzi, Lucia; Villafañe, Jorge H; Capra, Francesco; Reci, Marsida; Pillastrini, Paolo

    2015-03-01

    The objectives of this study were to determine the effectiveness of a programme of prevention exercises conducted in a corporate environment in poultry industry slaughterers suffering from musculoskeletal disorders. Forty workers, 70% female (mean ± SD age: 44.4 ± 8.4 years) were consecutively, in an alternative way, assigned to one of two groups receiving either set of 10 sessions (experimental or control group). The experimental group followed an exercise programme for a period of five weeks and a protocol of home exercises. The control group performed the exercise protocol only at home. The Roland Morris Disability Questionnaire (RMDQ) and the Oswestry Disability Index (ODI) to measure disability, the Visual Analogue Scale (VAS) score and the Pain Drawing to measure pain were used as outcome evaluations. A significant effect of time interaction (all P <0.001 and; F = 40.673; F = 33.907 and F = 25.447) existed for lumbar VAS, RMDQ and ODI immediately after the intervention (all P < 0.006). No significant group effect or group-by-time interaction was detected for any of them, which suggests that both groups improved in the same way. This study shows that a programme of prevention exercises may have a positive effect in improving musculoskeletal disorders of slaughterhouse workers. Pain decreased in the lumbar region, and there was an almost significant reduction in disability.

  4. Effects in Short and Long Term of Global Postural Reeducation (GPR) on Chronic Low Back Pain: A Controlled Study with One-Year Follow-Up

    PubMed Central

    Cecchi, Francesca; Del Canto, Antonio; Paperini, Anita; Boni, Roberta; Pasquini, Guido; Vannetti, Federica; Macchi, Claudio

    2015-01-01

    Objective. Comparing global postural reeducation (GPR) to a standard physiotherapy treatment (PT) based on active exercises, stretching, and massaging for improving pain and function in chronic low back pain (CLBP) patients. Design. Prospective controlled study. Setting. Outpatient rehabilitation facility. Participants. Adult patients with diagnosis of nonspecific, chronic (>6 months) low back pain. Interventions. Both treatments consisted of 15 sessions of one hour each, twice a week including patient education. Measures. Roland Morris Disability Questionnaire to evaluate disability, and Numeric Analog Scale for pain. A score change >30% was considered clinically significant. Past treatments, use of medications, smoking habits, height, weight, profession, and physical activity were also recorded on baseline, on discharge, and 1 year after discharge (resp., T0, T1, and T2). Results. At T0 103 patients with cLBP (51 cases and 52 controls) were recruited. The treatment (T1) has been completed by 79 (T1) of which 60 then carried out the 1-year follow-up (T2). Both GPR and PT at T1 were associated with a significant statistical and clinical improvement in pain and function, compared to T0. At T2, only pain in GPR still registered a statistically significant improvement. PMID:25945360

  5. [A political matter: science and ideology in the 21st century].

    PubMed

    Wahrig, Bettina

    2010-06-01

    In the last two decades, history of science and science studies have been quite reluctant to adopt the notion of ideology when analyzing the dynamics of science. This may be an effect of the decreasing popularity of neo-marxist approaches within this disciplinary field; but it is also due to the fact that alternative approaches have been developed, for example Michel Foucault's notion of problematization, Roland Barthes' semiotic mythology, Bruno Latour's re-interpretation of the ontological difference between fact and fetish in science, or Donna Haraway's semi-fictional re-narrations of the techno-scientific world. This contribution undertakes to sketch the impact of two strands of 19th century immanentism on the authors named above, and on their use of concepts related to the notion of ideology, namely fetish, fetishism, myth and mythology respectively. It is argued that in some respect, Marx' concept of commodity fetishism is worth being re-examined, since it articulates a dialectical relation of 'reality' and 'seeming', and its impact on Barthes' mythology is deeper than it might appear at first glance.

  6. Illness, everyday life and narrative montage: the visual aesthetics of cancer in Sara Bro's Diary.

    PubMed

    Henriksen, Nina; Tjørnhøj-Thomsen, Tine; Hansen, Helle Ploug

    2011-05-01

    This article presents a study of Sara Bro's Diary (2004), a book montage of images and texts recording the experiences of a Danish breast cancer survivor, Sara Bro. It examines two montages of photography and text, drawing on Roland Barthes' concept of 'the third meaning' to explain and discuss the effect of the layered meanings in the montage alongside their multi-medium and self-referential expression. The discussion is centred on the aesthetic practices that are invited by Bro's book montage. The article considers how the juxtaposition of images and texts are experienced and co-created by the reader. It points to the effect of the aesthetics of disguise and carnival implicit in the visual-verbal montage and argues that these generate a third meaning. This meaning is associated with the breast cancer experience but is not directly discernible in the montage. The article concludes by discussing how Bro's montage acts as an ideological statement, subverting or 'poaching on' the health care system.

  7. The narrative structure of psychiatric reports.

    PubMed

    Verde, Alfredo; Angelini, Francesca; Boverini, Silvia; Majorana, Margherita

    2006-01-01

    The present contribution illustrates the findings of a research about the narrative structure of psychiatric expertise. We have analysed a sample of nine expertises, using the methodology proposed by Roland Barthes in his book S/Z, in which he applies it to Honoré de Balzac's "Sarrasine". Barthes suggests that every narrative is characterized by the presence of five codes (hermeneutical, proairetic, semantic, symbolic and referential): we have searched for them in the expertises, but we have also observed the presence of many lapsus calami. As for our results, we have interpreted the massive presence of symbolic code in an expertise as a proof of the elaboration of the horror elicited by crime in the expert's narrative and, on the other side, the presence of referential code as the proof of the incapacity to treat such feeling and the necessity to defend himself from it. In this vision, lapsuses arise when the expert is astonished by the horror of the crime, and does not succeed in elaborating it either by using symbolic code or through his cultural resources (referential code). Finally, some reflections are made upon the difficulty for the voice of the defendant to be heard in the texts written about him.

  8. Was killing the queer author necessary to liberate the queer text?: the case of Andy Warhol's A: a novel.

    PubMed

    Hardin, Michael

    2009-01-01

    In the decades since Roland Barthes' "The Death of the Author" (1968), Michel Foucault's "What Is an Author?" (1969), and Andy Warhol's novel A (1968), we have become comfortable with the idea that the author is separate from the text. In many ways, however, killing the author was an unnecessary act since critics inherently read their own ideas into texts. Within the span of less than two years, all three texts proposed the removal of the author from the text, all three by prominent gay men in academia and art. The act of removing the author represented a kind of closet protection, separating artist from art, author from text. This aricle examines the convergence of ideas of Barthes and Foucault and how they relate to Warhol's A. In these writers and texts, we see a sexuality eager to burst forth from the page, but one that is hesitant, worried that the sexual politics of the late 1960s are not so liberated as to freely accept homosexuality among the artistic and academic elite. This is the real tragedy in the death of the author, when the identity and spirit of the artist/writer is so denied by the audience that not only is the sexuality lost, but the artist as well.

  9. Savage poetry: torture and cruelty in Mirbeau and Barbey d'Aurevilly.

    PubMed

    Thompson, Hannah

    2010-01-01

    Octave Mirbeau's Le Jardin des supplices and Barbey d'Aurevilly's L'Ensorcelée and Les Diaboliques depict a range of cruel attacks on the human body. These examples of violence, hitherto neglected by critical readers of the texts, have much to tell us not only about the authors' approach to violence, but also about the relationships between author, reader, and text that such representations of violence foreground. The notion of readerly pleasure theorized by Roland Barthes and linked to identity formation by Emma Wilson is associated with the witnessing or experiencing of pain in these texts. The reader is problematically positioned as both sadist, vicariously enjoying the suffering he or she is forced to witness, and masochist, taking pleasure in the authors' manipulations of them. These depictions of violated bodies ask whether and by what means violence can be represented in language, and this discussion leads to an analysis of the impact that such representations of violence have on the reader's experience of a text.

  10. Dipolar Effects in an Ultracold Gas of LiCs Molecules

    NASA Astrophysics Data System (ADS)

    Weidemueller, Matthias

    2011-05-01

    Recently, there has been important progress in the investigation of ultracold polar molecules in the absolute ground state, thus opening intriguing perspectives for strongly correlated quantum systems under the influence of long-range dipolar forces. We have studied the formation of LiCs molecules via photoassociation (PA) in a double-species magneto-optical trap. The LiCs dimer is a particularly promising candidate for observing dipolar effects, as it possesses the largest dipole moment of all alkali dimers (5.5 Debye in the ground state). Ultracold LiCs molecules in the absolute rovibrational ground state are formed by a single photo-association step. The dipole moment of ground state levels is determined by Stark spectroscopy and was found to be in excellent agreement with the theoretical predictions. Vibrational redistribution due to spontaneous emission and blackbody radiation is observed and compared a rate-equation model.In collaboration with Johannes Deiglmayr, Marc Repp, University of Heidelberg; Roland Wester, University of Innsbruck; and Olivier Dulieu, Laboratoire Aime Cotton. Work was supported by DFG and ESF in the framework of the Eurocores EuroQUAM as well as the Heidelberg Center for Quantum Dynamics.

  11. Universality of the onset of activated transport in Lennard-Jones liquids with tunable coordination: Implications for the effects of pressure and directional bonding on the crossover to activated transport, configurational entropy, and fragility of glassforming liquids

    NASA Astrophysics Data System (ADS)

    Rabochiy, Pyotr; Lubchenko, Vassiliy

    2012-02-01

    We establish, via classical density functional theory, that the crossover to activated transport in liquids takes place when the depth of the metastable minimum in the free energy corresponding to long-lived aperiodic structures reaches a certain near universal value. We show that the particle vibrational displacement is strongly correlated with this depth in a broad range of pressure and temperature, thus providing basis for a Lindemann-like criterion for the onset of activated transport in liquids. The configurational entropy at the crossover temperature Tcr, too, is found to be nearly system-independent, consistent with the random first order transition theory. We show that to reproduce existing data for the pressure dependence of Tcr, the liquid must increase its coordination with pressure. Upon increasing pressure at fixed coordination, the liquid's fragility is predicted to exhibit re-entrant behavior. This prediction is consistent with glycerol data but is in contrast with data in several organic liquids and polymers, whose fragility monotonically decreases with pressure in the so far accessed pressure range. Allowing for increase in coordination with pressure mitigates the disagreement, owing to the resulting decrease in the thermal expansivity. Finally, we rationalize the correlation between the isobaric and isochoric fragilities put forth by Casalini and Roland [Phys. Rev. E 72, 031503 (2005), 10.1103/PhysRevE.72.031503] and make predictions on the limiting behavior of the fragility at high pressure.

  12. With Weekly Astronomy Tips Against the Weekly Papers' Astrology Humbug

    NASA Astrophysics Data System (ADS)

    Szécsényi-Nagy, G. A.

    2006-08-01

    The true democracy - following a long lasting monolithic political-cultural system of the so-called Peoples' Democracy -- freed the sluices in the early nineties for any absurd written idea. No really powerful newspapers or widely circulated magazines were allowed to publish any destructive astrological advice during those 40 years. Although here and there, somehow, it appeared cloaked but was unable to reach the wide public. The first signs of these unwanted changes reached our nation through the electronic media (first of all television, of course ) but very soon a whirl of everyday astrology has occupied a substantial part of almost every newspaper.This situation urges professional and amateur astronomers, astrophysicists, as well as other skeptic scientists and journalists to set their face against any ideas of pseudo-science. In our country, the most has been done by the Hungarian Astronomical Association and the Roland Eötvös Physical Society.I intend to call the attention of our colleagues from other countries and regions to these brave initiatives, and inform them on some useful steps and their first results. I also expect a vivid exchange of the opinions and strategies that can build and develop a wiser society in the over-industrialized or consuming-oriented countries

  13. Diffusion imaging of cerebral white matter in persons who stutter: evidence for network-level anomalies

    PubMed Central

    Cai, Shanqing; Tourville, Jason A.; Beal, Deryk S.; Perkell, Joseph S.; Guenther, Frank H.; Ghosh, Satrajit S.

    2013-01-01

    Deficits in brain white matter have been a main focus of recent neuroimaging studies on stuttering. However, no prior study has examined brain connectivity on the global level of the cerebral cortex in persons who stutter (PWS). In the current study, we analyzed the results from probabilistic tractography between regions comprising the cortical speech network. An anatomical parcellation scheme was used to define 28 speech production-related ROIs in each hemisphere. We used network-based statistic (NBS) and graph theory to analyze the connectivity patterns obtained from tractography. At the network-level, the probabilistic corticocortical connectivity from the PWS group were significantly weaker than that from persons with fluent speech (PFS). NBS analysis revealed significant components in the bilateral speech networks with negative correlations with stuttering severity. To facilitate comparison with previous studies, we also performed tract-based spatial statistics (TBSS) and regional fractional anisotropy (FA) averaging. Results from tractography, TBSS and regional FA averaging jointly highlight the importance of several regions in the left peri-Rolandic sensorimotor and premotor areas, most notably the left ventral premotor cortex (vPMC) and middle primary motor cortex, in the neuroanatomical basis of stuttering. PMID:24611042

  14. Functional capacity and its associated factors in the elderly with low back pain

    PubMed Central

    Palma, Roger; de Conti, Marta Helena Souza; Quintino, Natasha Mendonça; Gatti, Marcia Aparecida Nuevo; Simeão, Sandra Fiorelli Almeida Penteado; de Vitta, Alberto

    2014-01-01

    OBJECTIVE: To assess the level of functional capacity in subjects aged 60 years and older, who have lower back pain, and its association with demographic, socioeconomic, work-related, lifestyle-related and disease mentioned variables. METHODS: A cross-sectional study was conducted with 246 elderly registered at the Family Health Strategy of Vila São Paulo, Bauru,SP, Brazil, who reported lower back pain and were sampled by a two-stage cluster technique. The subjects were interviewed at home by using a multidimensional instrument (demographic; socioeconomic aspects; life style; work characterization; disease mentioned), and also the IPAQ, the Nordic and the Roland Morris questionnaires. A bivariate and multivariate descriptive logistic regression analysis was carried out. RESULTS: The prevalence of lower back pain in men was of 25.1% and in women it was of 35.1%. The mean score in the functional capacity assessment was 10.46 ± 5.62. A fraction of 67.5% of the elderly demonstrated an inappropriate functional capacity. The age group from 70 to 80 years old, the subjects reporting three or more diseases and the sedentary group presented an independent association with inappropriate functional capacity. CONCLUSION: The older, sedentary subjects and who reported more than three diseases presented low functional capacity. Level of Evidence III, Cross Sectioning. PMID:25538473

  15. Effect of Magnitude Estimation of Pleasantness and Intensity on fMRI Activation to Taste.

    PubMed

    Cerf-Ducastel, B; Haase, L; Murphy, C

    2012-03-01

    The goal of the present study was to investigate whether the psychophysical evaluation of taste stimuli using magnitude estimation influences the pattern of cortical activation observed with neuroimaging. That is, whether different brain areas are involved in the magnitude estimation of pleasantness relative to the magnitude estimation of intensity. fMRI was utilized to examine the patterns of cortical activation involved in magnitude estimation of pleasantness and intensity during hunger in response to taste stimuli. During scanning, subjects were administered taste stimuli orally and were asked to evaluate the perceived pleasantness or intensity using the general Labeled Magnitude Scale (Green 1996, Bartoshuk et al. 2004). Image analysis was conducted using AFNI. Magnitude estimation of intensity and pleasantness shared common activations in the insula, rolandic operculum, and the medio dorsal nucleus of the thalamus. Globally, magnitude estimation of pleasantness produced significantly more activation than magnitude estimation of intensity. Areas differentially activated during magnitude estimation of pleasantness versus intensity included, e.g., the insula, the anterior cingulate gyrus, and putamen; suggesting that different brain areas were recruited when subjects made magnitude estimates of intensity and pleasantness. These findings demonstrate significant differences in brain activation during magnitude estimation of intensity and pleasantness to taste stimuli. An appreciation for the complexity of brain response to taste stimuli may facilitate a clearer understanding of the neural mechanisms underlying eating behavior and over consumption.

  16. Computer-aided combined movement examination of the lumbar spine and manual therapy implications: Case report.

    PubMed

    Monie, A P; Barrett, C J; Price, R I; Lind, C R P; Singer, K P

    2016-02-01

    Combined movement examination (CME) of the lumbar spine has been recommended for clinical examination as it confers information about mechanical pain patterns. However, little quantitative study has been undertaken to validate its use in manual therapy practice. This study used computer aided CME to develop a normal reference range, and to guide provisional diagnosis and management. Two cases were assessed, before and after manual therapy using CME, a pain Visual Analogue Scale, the Roland Morris Low Back Pain and Disability Questionnaire and the Short Form (SF-12) Health Survey. Diagnosis and management were guided by comparing each CME pattern with the age and gender matched reference range. Self-reports data and CME total change scores were markedly improved for both cases, particularly for the most painful and restricted CME directions. This report describes how computer-aided CME and a normal reference range may be used objectively to inform a diagnosis and as an outcome measure in cases of mechanical LBP. Future investigations of cases with specific lumbar pathologies are required to validate this concept.

  17. The Effect of Harmonic Technique vs End Range Loading Exercises on Pain and Disability in Patients With Non-Specific Chronic Low Back Pain: A Preliminary Study

    PubMed Central

    Arab, Amir Massoud; Saadati, Heidar; Sheikhhoseini, Rahman

    2016-01-01

    Objective The purpose of this study was to compare the effects of end range loading (ERL) vs harmonic technique (HT) on patients with chronic low back pain (LBP). Method Fourteen volunteer patients with LBP were randomly assigned to 2 groups based on a blocked randomization method with 7 patients in the HT group and 7 patients in the ERL group. The patients received 10 sessions of treatment for 5 sessions per week. Pain intensity and disability score were recorded using the numeric pain scale and Roland-Morris Disability questionnaire (RMQ), respectively, before and after the treatment period. Results Although pain intensity (P = .02) and the RMQ score (P = .03) decreased in the HT technique group, no statistically significant change was found in the ERL group for the RMQ score (P > .05). The effect size for HT was .6 and .3 for numeric pain scale and RMQ, respectively. Conclusion This preliminary study showed that pain intensity and disability improved in subjects with chronic LBP in the HT group. More investigations with larger sample size are needed to clarify these findings. PMID:27069426

  18. The clinical and biomechanical effects of fascial-muscular lengthening therapy on tight hip flexor patients with and without low back pain

    PubMed Central

    Avrahami, Daniel; Potvin, Jim R.

    2014-01-01

    Background: Many patients have tight hip flexors with or without low back pain. Manual fascial-muscular lengthening therapy (FMLT) is one commonly used treatment for this population. Objective: Investigate the clinical and biomechanical effects of manual FMLT on tight hip flexor patients with and without low back pain. Methods: A nonrandomized trial, before-and-after experiment with multiple baselines conducted on two different patient populations: 1) Mechanical low back pain patients with tight hip flexors (n = 10) and 2) Asymptomatic group with tight hip flexors (n = 8). Four treatments of manual FMLT were performed on the hip flexor of the two groups of patients over a two-week period. Primary outcome measures over the two-week period were 1) Maximum voluntary trunk flexor and extensor moments, 2) Disability (Roland Morris Disability Questionnaire) and pain (10-cm Visual Analogue Scale), 3) Passive hip extension mobility. Results: Primary outcome analysis involved within-groups comparisons. Maximum voluntary trunk extension demonstrated increases for the low back pain patients. The low back pain patients demonstrated a small, but significant, reduction in disability and pain. Both groups demonstrated an increase in passive hip extension measurements. Conclusion: This preliminary study demonstrated interesting results from manual FMLT on two tight hip flexor patient populations with and without low back pain. However, there were several significant limitations from this study, which restrict the ability to generalize the results. PMID:25550670

  19. Dynamic heterogeneity above and below the mode-coupling temperature

    NASA Astrophysics Data System (ADS)

    Flenner, Elijah; Szamel, Grzegorz

    2012-02-01

    We study the temperature dependence of the spatial extend of the dynamic heterogeneity in a soft sphere system near the so-called mode-coupling temperature Tc. We utilize a recently introduced procedureootnotetextE. Flenner and G. Szamel, Phys. Rev. Lett. 105, 217801 (2010) to calculate the ensemble independent dynamic susceptibility χ4(τα) and the dynamic correlation length ξ(τα) at the alpha relaxation time τα. Above Tc, we find that χ4(τα) ˜ξ(τα)^3 and ξ(τα) ˜(τα), which is the same behavior found in a binary hard-sphere system. We track these relationships below Tc to examine the recently reported non-monotonic temperature dependence of dynamic correlations found in the same systemootnotetextW. Kob, S. Roland-Vargas and L. Berthier, Nat. Phys. DOI:10.1038/NPHYS2133. Finally, we examine the relationship between dynamic susceptibilities that can be determined from experiments and the dynamic correlation length ξ(τα).

  20. Efficacy of acupuncture for degenerative lumbar spinal stenosis: protocol for a randomised sham acupuncture-controlled trial

    PubMed Central

    Qin, Zongshi; Ding, Yulong; Wu, Jiani; Zhou, Jing; Yang, Likun; Liu, Xiaoxu; Liu, Zhishun

    2016-01-01

    Introduction Degenerative lumbar spinal stenosis (DLSS) is a major public health problem and the primary reason why older adults seek lumbar spine surgery. Acupuncture may be effective for DLSS, but the evidence supporting this possibility is still limited. Methods and analysis A total of 80 participants with DLSS will be randomly allocated to either an acupuncture group or a sham acupuncture (SA) group at a ratio of 1:1. 24 treatments will be provided over 8 weeks. The primary outcome is the score change of the Modified Roland-Morris Disability Questionnaire (RMDQ) responses from baseline to week 8. The secondary outcomes include the assessment of lower back pain and leg pain using the Numeric Rating Scale (NRS), the change in the number of steps per month, and the assessment of the specific quality of life using the Swiss Spinal Stenosis Questionnaire (SSSQ). We will follow-up with the participants until week 32. All of the participants who received allocation will be included in the statistical analysis. Ethics/dissemination This protocol has been approved by the Research Ethical Committee of Guang'anmen Hospital (Permission number: 2015EC114) and Fengtai Hospital of Integrated Traditional and Western Medicine (Permission number: 16KE0409). The full data set will be made available when this trial is completed and published. Applications for the release of data should be made to ZL (principal investigator). Trial registration number NCT02644746. PMID:27852717

  1. Approach for a Global Height Reference System

    NASA Astrophysics Data System (ADS)

    Ihde, Johannes

    2015-04-01

    Hermann Drewes, Christoph Foerste, Thomas Gruber, Gunter Liebsch, Roland Pail, Laura Sanchez For Earth system monitoring the heights are main parameters for global changes. Physical heights are potential differences of the outer Earth gravity field at different positions. Long term monitoring of the vertical component of the Earth surface needs a standardized defined and realized global reference relating the geometry and the gravity field of the Earth. In the last two decades, in several working groups of the International Association of Geodesy were different concepts for definition and realization of global height reference system discussed. Furthermore, the satellite gravity missions have the Earth gravity field data basis general extended. So far, it is possible to develop the present local and regional height reference systems concepts to a global approach. The presented proposal has to be understood as a model that consider the present possibilities and actual needs for the realization of a global height reference system. It includes aspects for the combination of observations and products representing the geometry and the gravity field of the Earth.

  2. The Many Faces of Elongator in Neurodevelopment and Disease

    PubMed Central

    Kojic, Marija; Wainwright, Brandon

    2016-01-01

    Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons. Malfunction of these highly regulated and coordinated events results in various neurological diseases. The Elongator complex is a multi-subunit complex highly conserved in eukaryotes whose function has been implicated in the majority of cellular activities underlying neurodevelopment. These activities include cell motility, actin cytoskeleton organization, exocytosis, polarized secretion, intracellular trafficking and the maintenance of neural function. Several studies have associated mutations in Elongator subunits with the neurological disorders familial dysautonomia (FD), intellectual disability (ID), amyotrophic lateral sclerosis (ALS) and rolandic epilepsy (RE). Here, we review the various cellular activities assigned to this complex and discuss the implications for neural development and disease. Further research in this area has the potential to generate new diagnostic tools, better prevention strategies and more effective treatment options for a wide variety of neurological disorders. PMID:27847465

  3. Evaluation of metabolic syndrome in patients with chronic low back pain.

    PubMed

    Duruöz, Mehmet Tuncay; Turan, Yasemin; Gürgan, Alev; Deveci, Hülya

    2012-03-01

    The aim of our study was to investigate the frequency of the metabolic syndrome in chronic low back pain and evaluate the differences in clinical and functional parameters in chronic low back pain patients with and without metabolic syndrome. Patients complaining of low back pain complaint lasting for at least 2 months were included in the study. In order to establish functional deficiency, Roland-Morris Disability Questionnaire, Istanbul Low Back Pain Disability Index and Oswestry Disability Index were used. To evaluate depression, Beck's depression scale was used. The diagnosis of metabolic syndrome was made according to the criteria of National Cholesterol Education Program (NCEP) defined in 2001. For this; lumbar circumference around anterior iliac spine, arterial blood pressure, fasting blood glucose, plasma triglyceride levels and HDL cholesterol levels were noted down. Sixty patients (51 women) were included in the study. There was significant difference in terms of BMI (P = 0.034), age (P = 0.001), waist circumference (P = 0.048) and disease duration (P = 0.005) between chronic low back pain patients with and without metabolic syndrome. There was no significant difference in other parameters. Low back pain is a frequent complaint amongst people with obesity in the abdominal area. According to our results, elderly people, people with chronic low back pain and patients with high BMI are under risk for metabolic syndrome. For this reason this group of patients can be screened for metabolic syndrome and preventive measures can be taken.

  4. Plasma-photocatalysis combination for air pollutant removal: identification of the synergy mechanisms

    NASA Astrophysics Data System (ADS)

    Guaitella, O.; Thevenet, F.; Rousseau, A.; Guillard, C.; Stancu, G.; Roepcke, J.

    2006-10-01

    The coupling of a photocatalyst with a non thermal plasma (DBD) is studied; based on experimental results we discuss separately the contributions of (i) the chemistry involved as a function of the porosity of the material, and (ii) the influence of the photocatalytic activity on the chemistry of C2H2 oxidation. C2H2 removal is strongly increased by the presence of a porous material (SiO2 or TiO2): the destruction of C2H2 is driven by species created by the plasma and concentrated by a porous [1]. Our experiments confirm that C2H2 removal rate increases with the porosity of the material, whereas the selectivity also depends on the chemical composition of the surface. In parallel, the temporal evolution of C2H2 concentration was measured by Tuneable Diode Laser Absorption Spectroscopy (TDLAS) in the mid infrared region in a low pressure discharge during a single plasma pulse (one shot). The contribution of external ultraviolet radiation and plasma exposure were quantified, both with and without photocatalyst. The synergetic effect was clearly demonstrated [2]. [1] U. Roland, F. Holzer, F.-D. Kopinke 2002 Catalysis Today 73 315--323 [2] A. Rousseau, O. Guaitella, L.V. Gatilova, F. Thevenet, C. Guillard, J. Roepcke, G. D. Stancu , Appl. Phys. Let. 87, 221501 (2005).

  5. The phonological short-term store-rehearsal system: patterns of impairment and neural correlates.

    PubMed

    Vallar, G; Di Betta, A M; Silveri, M C

    1997-06-01

    Two left brain-damaged patients (L.A. and T.O.) with a selective impairment of auditory-verbal span are reported. Patient L.A. was unable to hold auditory-verbal material in the phonological store component of short-term memory. His performance was however normal on tasks requiring phonological judgements, which specifically involve the phonological output buffer component of the rehearsal process. He also showed some evidence that rehearsal contributed to the immediate retention of auditory-verbal material. Patient T.O. never made use of the rehearsal process in tasks assessing both immediate retention and the ability to make phonological judgements, but the memory capacity of the phonological short-term store was comparatively preserved. These contrasting patterns of impairment suggest that the phonological store component of verbal short-term memory was severely impaired in patient L.A., and spared, at least in part, in patient T.O. The rehearsal process was preserved in L.A., and primarily defective in T.O. The localisation of the lesions in the left hemisphere (L.A.: inferior parietal lobule, superior and middle temporal gyri; T.O.: sub-cortical premotor and rolandic regions, anterior insula) suggests that these two sub-components of phonological short-term memory have discrete anatomical correlates.

  6. Atlas of Great Comets

    NASA Astrophysics Data System (ADS)

    Stoyan, Ronald; Dunlop, Storm

    2015-01-01

    Foreword; Using this book; Part I. Introduction: Cometary beliefs and fears; Comets in art; Comets in literature and poetry; Comets in science; Cometary science today; Great comets in antiquity; Great comets of the Middle Ages; Part II. The 30 Greatest Comets of Modern Times: The Great Comet of 1471; Comet Halley 1531; The Great Comet of 1556; The Great Comet of 1577; Comet Halley, 1607; The Great Comet of 1618; The Great Comet of 1664; Comet Kirch, 1680; Comet Halley, 1682; The Great Comet of 1744; Comet Halley, 1759; Comet Messier, 1769; Comet Flaugergues, 1811; Comet Halley, 1835; The Great March Comet of 1843; Comet Donati, 1858; Comet Tebbutt, 1861; The Great September Comet of 1882; The Great January Comet of 1910; Comet Halley, 1910; Comet Arend-Roland, 1956; Comet Ikeya-Seki, 1965; Comet Bennett, 1970; Comet Kohoutek, 1973-4; Comet West, 1976; Comet Halley, 1986; Comet Shoemaker-Levy 9, 1994; Comet Hyakutake, 1996; Comet Hale-Bopp, 1997; Comet McNaught, 2007; Part III. Appendices; Table of comet data; Glossary; References; Photo credits; Index.

  7. The Effects of VR-based Wii Fit Yoga on Physical Function in Middle-aged Female LBP Patients

    PubMed Central

    Kim, Seong-Sik; Min, Won-Kyu; Kim, Jung-Hee; Lee, Byoung-Hee

    2014-01-01

    [Purpose] The purpose of this research was to determine the effects of a virtual reality-based yoga program on middle-aged female low back pain patients. [Subjects and Methods] Thirty middle-aged female patients who suffered from low back pain were assigned to either a physical therapy program or a virtual reality-based yoga program for a period of four weeks. Participants could check their posture and weight bearing on a monitor as they shifted their weight or changed their postures on a Wii balance board. There were a total of seven exercise programs. A 30-minute, three times per week, virtual reality-based Wii Fit yoga program or trunk stabilizing exercise was performed, respectively. [Results] Repeated-measures analysis of covariance revealed significant differences in between pre- and post-training VAS, algometer, Oswestry low-back pain disability index (ODI), Roland Morris disability questionnaire (RMDQ), and fear avoidance beliefs questionnaire (FBQ) scores. The VAS, algometer, ODI, RMDQ, and FBQ scores showed significant differences in groups. Regarding the effect of time-by-group interaction, there were significant differences in VAS, ODI, ODI, and FBQ scores. [Conclusion] In conclusion, for middle-aged female patients who have low back pain, a virtual reality-based yoga program was shown to have positive effects on physical improvements, and this program can be employed as a therapeutic medium for prevention and cure of low back pain. PMID:24764631

  8. General Aspects

    NASA Astrophysics Data System (ADS)

    Höfle, Gerhard

    Epothilone is a microbial product, and thus its history may be traced back to the discovery of the respective microbe, Sorangium cellulosum, a bacterium belonging to the taxonomic group of myxobacteria, which originally has been described by Roland Thaxter in 1892 (1). Today this group of organisms comprises around 40 species, one of which is Sorangium cellulosum. For a long time, myxobacteria were only known for their gliding motility and sophisticated life cycle, although it had been occasionally speculated that they might produce secondary metabolites like actinomycetes or bacilli (2). In 1975 Hans Reichenbach and his group at the German Centre for Biotechnology (GBF; now called the Helmholtz Centre for Infection Research) set out to isolate strains of myxobacteria from soil samples collected all over the world, and to examine their secondary metabolism. In 1978, while work was already ongoing, I joined them and took over the chemistry part. In the same year the first structure of a myxobacterial metabolite, ambruticin, was published by a group from Warner-Lambert (3) making us very confident of being on the right track. Ambruticin had been isolated from a Sorangium cellulosum strain, and was identified as a unique cyclopropane polyketide structure exhibiting potentially useful antifungal properties. Ambruticin and its derivatives had been developed for medical application for some time, and recently gained new interest (4).

  9. Fullerenes produced by harnessing sunlight

    SciTech Connect

    Not Available

    1993-08-01

    Two independent groups of researchers have demonstrated that fullerenes can be produced by harnessing focused sunlight to vaporize carbon. Adapted to a large scale, generation of the carbon-cage molecules in solar furnaces might overcome yield-limiting problems associated with other fullerene production techniques, the researchers suggest. At Rice University, Houston, chemistry professor Richard E. Smalley and graduate students L.P. Felipe Chibante, Andreas Thess, J. Michael Alford, and Michael D. Diener used a parabolic mirror to focus sunlight on a graphite target to produce what appears to be a high yield of fullerenes. At the National Renewable Energy Laboratory (NREL), Golden, Colo., Roland R. Pitts, Mary Jane Hale, Carl Bingham, Allan Lewandowski, and David E.King, working in collaboration with Clark L. Fields, a chemistry professor at the University of Northern Colorado, Greeley, used NREL's high-flux solar furnace to produce soot that contains C[sub 60] and C[sub 70]. Papers describing the Rice and NREL results appeared together in last week's Journal of Physical Chemistry (97, 8696 and 8701 (1993)).

  10. Auricular Point Acupressure to Manage Chronic Low Back Pain in Older Adults: A Randomized Controlled Pilot Study

    PubMed Central

    Morone, Natalia E.; Cao, Yuling; Shen, Juan; Bhatnagar, Shreya; Liang, Zhan; Glick, Ronald M.; Suen, Lorna Kwai-Ping

    2014-01-01

    This prospective, randomized clinical trial (RCT) pilot study was designed to (1) assess the feasibility and tolerability of an easily administered, auricular point acupressure (APA) intervention and (2) provide an initial assessment of effect size as compared to a sham treatment. Thirty-seven subjects were randomized to receive either the real or sham APA treatment. All participants were treated once a week for 4 weeks. Self-report measures were obtained at baseline, weekly during treatment, at end-of-intervention (EOI), and at a 1-month follow-up. A dropout rate of 26% in the real APA group and 50% in the sham group was observed. The reduction in worst pain from baseline to EOI was 41% for the real and 5% for the sham group with a Cohen's effect size of 1.22 (P < 0.00). Disability scores on the Roland Morris Disability Questionnaire (RMDQ) decreased in the real group by 29% and were unchanged in the sham group (+3%) (P < 0.00). Given the high dropout rate, results must be interpreted with caution; nevertheless, our results suggest that APA may provide an inexpensive and effective complementary approach for the management of back pain in older adults, and further study is warranted. PMID:25147574

  11. It's in the eye of the beholder: selective attention to drink properties during tasting influences brain activation in gustatory and reward regions.

    PubMed

    van Rijn, Inge; de Graaf, Cees; Smeets, Paul A M

    2017-03-20

    Statements regarding pleasantness, taste intensity or caloric content on a food label may influence the attention consumers pay to such characteristics during consumption. There is little research on the effects of selective attention on taste perception and associated brain activation in regular drinks. The aim of this study was to investigate the effect of selective attention on hedonics, intensity and caloric content on brain responses during tasting drinks. Using functional MRI brain responses of 27 women were measured while they paid attention to the intensity, pleasantness or caloric content of fruit juice, tomato juice and water. Brain activation during tasting largely overlapped between the three selective attention conditions and was found in the rolandic operculum, insula and overlying frontal operculum, striatum, amygdala, thalamus, anterior cingulate cortex and middle orbitofrontal cortex (OFC). Brain activation was higher during selective attention to taste intensity compared to calories in the right middle OFC and during selective attention to pleasantness compared to intensity in the right putamen, right ACC and bilateral middle insula. Intensity ratings correlated with brain activation during selective attention to taste intensity in the anterior insula and lateral OFC. Our data suggest that not only the anterior insula but also the middle and lateral OFC are involved in evaluating taste intensity. Furthermore, selective attention to pleasantness engaged regions associated with food reward. Overall, our results indicate that selective attention to food properties can alter the activation of gustatory and reward regions. This may underlie effects of food labels on the consumption experience of consumers.

  12. STS-93 crew members look at top of external tank in VAB

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Inside the Vehicle Assembly Building, two STS-93 crew members, (center) Mission Specialist Michel Tognini of France and Pilot Jeffrey S. Ashby, get a close look at something seldom seen, the tip of an external tank. With them are Roland Nedelkovich (far left), with the Vertical Integration Test Team, and John Hlavacka (far right). STS-93 is scheduled to launch July 9 aboard Space Shuttle Columbia and has the primary mission of the deployment of the Chandra X-ray Observatory. Formerly called the Advanced X-ray Astrophysics Facility, Chandra comprises three major elements: the spacecraft, the science instrument module (SIM), and the world's most powerful X-ray telescope. Chandra will allow scientists from around the world to see previously invisible black holes and high-temperature gas clouds, giving the observatory the potential to rewrite the books on the structure and evolution of our universe. Other STS-93 crew members are Commander Eileen M. Collins and Mission Specialists Catherine G. Coleman and Steven A. Hawley.

  13. Aberrant functional brain connectome in people with antisocial personality disorder

    PubMed Central

    Tang, Yan; Long, Jun; Wang, Wei; Liao, Jian; Xie, Hua; Zhao, Guihu; Zhang, Hao

    2016-01-01

    Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016–0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD. PMID:27257047

  14. Altered gray matter organization in children and adolescents with ADHD: a structural covariance connectome study

    PubMed Central

    Griffiths, K R; Grieve, S M; Kohn, M R; Clarke, S; Williams, L M; Korgaonkar, M S

    2016-01-01

    Although multiple studies have reported structural deficits in multiple brain regions in attention-deficit hyperactivity disorder (ADHD), we do not yet know if these deficits reflect a more systematic disruption to the anatomical organization of large-scale brain networks. Here we used a graph theoretical approach to quantify anatomical organization in children and adolescents with ADHD. We generated anatomical networks based on covariance of gray matter volumes from 92 regions across the brain in children and adolescents with ADHD (n=34) and age- and sex-matched healthy controls (n=28). Using graph theory, we computed metrics that characterize both the global organization of anatomical networks (interconnectivity (clustering), integration (path length) and balance of global integration and localized segregation (small-worldness)) and their local nodal measures (participation (degree) and interaction (betweenness) within a network). Relative to Controls, ADHD participants exhibited altered global organization reflected in more clustering or network segregation. Locally, nodal degree and betweenness were increased in the subcortical amygdalae in ADHD, but reduced in cortical nodes in the anterior cingulate, posterior cingulate, mid temporal pole and rolandic operculum. In ADHD, anatomical networks were disrupted and reflected an emphasis on subcortical local connections centered around the amygdala, at the expense of cortical organization. Brains of children and adolescents with ADHD may be anatomically configured to respond impulsively to the automatic significance of stimulus input without having the neural organization to regulate and inhibit these responses. These findings provide a novel addition to our current understanding of the ADHD connectome. PMID:27824356

  15. Development of Sampling Techniques For Planetary Surfaces

    NASA Astrophysics Data System (ADS)

    Coste, P.; Eiden, M.; Gromov, V.; Ilykorpi, T.; Kochan, H.; Re, E.; Richter, L.

    During the last 15 years, the European Space Agency has initiated the development of a number of sampling techniques for planetary surfaces, in the frame of its basic Technology and Research Programme (TRP). Sampling may be performed by means of drilling, coring, milling, grain scooping or picking, and penetration. The items addressed in particular are: the Sample Acquisition System (SAS) for the late Comet Nucleus Sample and Return mission; the Small Sample Acquisition and Distribution Tool (SSA/DT): the Mole and the Sampling Mole (SM). Some of these devices have found a direct application within an ESA planetary mission, as expected; in other cases, their concept was used and modified to fulfill updated requirements. Sampling or soil probing capabilities are included to various extents in these current or near-future ESA missions: the Huygens Probe (on NASA's CASSINI spacecraft), on its way to Titan surface; the RoLand Lander (on ROSETTA s/c), onto Comet Wirtanen; the Beagle2 Lander (carried by MARS EXPRESS s/c) sampling the Martian surface and sub- surface. Future sampling missions to Mercury, the Moon and to asteroids are being studied. Even more challenging missions to Venus are considered.

  16. Purification of Staphylococcal β-Hemolysin and Its Action on Staphylococcal and Streptococcal Cell Walls

    PubMed Central

    Chesbro, William R.; Heydrick, Fred P.; Martineau, Roland; Perkins, Gail N.

    1965-01-01

    Chesbro, William R. (University of New Hampshire, Durham), Fred P. Heydrick, Roland Martineau, and Gail N. Perkins. Purification of staphylococcal β-hemolysin and its action on staphylococcal and streptococcal cell walls. J. Bacteriol. 89:378–389. 1965.—After growth of bovine-derived strains of Staphylococcus aureus in a completely dialyzable medium, the β-hemolysin in the culture supernatant fluids was purified by gradient-elution chromatography on cellulose phosphate. The purified hemolysin contained two components, demonstrable by immunodiffusion or electrophoresis, but was free from α-hemolysin, coagulase, Δ-hemolysin, enterotoxins A and B, glucuronidase, hyaluronidase, lipase, muramidase, Panton-Valentine leukocidin, phosphatase, and protease. The hemolysin was heat-labile and sulfhydryl-dependent, and the preparation was leukocidal for guinea pig macrophages. When rabbit red blood cell (RBC) stroma and staphylococcal or enterococcal cell walls were treated with the purified hemolysin, it liberated mucopolysaccharides from the rabbit RBC stroma, polysaccharides and mucopolysaccharides (or mucopeptides) from the staphyloccoal cell walls, and rhamnose, glucose, an unidentified monosaccharide, N-acetylglucosamine, and at least two polysaccharides from the enterococcal cell walls. The hemolytic and cell-wall degradative activities had similar thermal inactivation kinetics, pH optima, sedimentation coefficients, and chromatographic and electrophoretic mobilities; both required Mg and were inhibited by thiol-inactivating agents. Consequently, it seems likely that both activities are expressions of the same enzyme. PMID:14255704

  17. Prevalence and associations of neuropathic pain in a cohort of multi-ethnic Asian low back pain patients.

    PubMed

    Kew, Yueting; Tan, Cheng-Yin; Ng, Chong-Jing; Thang, Sue-Sien; Tan, Leong-Hooi; Khoo, Yvonne Khaii; Lim, Jun-Ni; Ng, Jia-Hui; Chan, Chris Yin-Wei; Kwan, Mun-Keong; Goh, Khean-Jin

    2017-04-01

    The prevalence of neuropathic low back pain differs in different ethnic populations. The aims of the study are to determine its frequency and associations in a multi-ethnic cohort of Asian low back pain patients. This was a cross-sectional study of low back patients seen at the University of Malaya Medical Centre, Kuala Lumpur, Malaysia. Neuropathic low back pain patients were identified using the painDETECT questionnaire and compared with non-neuropathic (unclear or nociceptive) low back pain patients, in terms of socio-demographic and clinical factors, pain severity (numerical pain rating scale, NPRS), disability (Roland Morris Disability Questionnaire, RMDQ), as well as anxiety and depression (Hospital Anxiety and Depression Scale, HADS). Of 210 patients, 26 (12.4%) have neuropathic low back pain. Neuropathic pain is associated with non-Chinese ethnicity, higher body mass index and pain radiation below the knee. Patients with neuropathic pain have significantly higher NPRS and RMDQ scores, and there are more subjects with anxiety on HADS. However, there are no differences between the groups in age, gender, pain duration or underlying diagnosis of low back pain. The prevalence of neuropathic low back pain in a multi-ethnic Malaysian cohort is lower than previously reported in other populations with possible differences between ethnic groups. It is associated with greater pain severity, disability and anxiety.

  18. Intrinsic Functional Plasticity of the Sensory-Motor Network in Patients with Cervical Spondylotic Myelopathy

    PubMed Central

    Zhou, F. Q.; Tan, Y. M.; Wu, L.; Zhuang, Y.; He, L. C.; Gong, H. H.

    2015-01-01

    Several neuroimaging studies have suggested brain reorganisation in patients with cervical spondylotic myelopathy (CSM); however, the changes in spontaneous neuronal activity that are associated with connectedness remain largely unknown. In this study, functional connectivity strength (FCS), a data-driven degree centrality method based on a theoretical approach, was applied for the first time to investigate changes in the sensory-motor network (SMN) at the voxel level. Comparatively, CSM not only showed significantly decreased FCS in the operculum-integrated regions, which exhibited reduced resting-state functional connectivity (rsFC) around the Rolandic sulcus, but it also showed increased FCS in the premotor, primary somatosensory, and parietal-integrated areas, which primarily showed an enhanced rsFC pattern. Correlation analysis showed that altered FCS (in the left premotor-ventral/precentral-operculum, right operculum-parietale 4, and right S1) was associated with worsening Japanese Orthopaedic Association scores and that the rsFC pattern was influenced by cervical cord micro-structural damage at the C2 level. Together, these findings suggest that during myelopathy, the intrinsic functional plasticity of the SMN responds to the insufficient sensory and motor experience in CSM patients. This knowledge may improve our understanding of the comprehensive functional defects found in CSM patients and may inspire the development of new therapeutic strategies in the future. PMID:25897648

  19. Adolescent patient with bilateral crossbite treated with surgically assisted rapid maxillary expansion: a case report evaluated by the 3d laser scanner, and using FESA method.

    PubMed

    Ivanov, Ch I; Velemínská, J; Dostálová, T; Foltán, R

    2011-01-01

    Our purpose in this case report is to present an orthodontic treatment obtained and the results achieved in 17-year-old white female patient with Angle Class II malocclusion and bilateral posterior crossbite. Patient was treated with bonded acrylic Hyrax appliance and surgically assisted rapid maxillary expansion (SARME). The multiloop system 0.16 TMA (ß titanium) arch wire was used in the alignment phase and on purpose to prohibit bite opening and optimize threedimensional movement control. After treatment bonded lingual retainers were placed in between maxillary central incisors and in mandible canine-to-canine. A functional removable Klammt appliance was used for retention. The 3D Laser Scanner Roland LPX-250 was used in order to obtain digital dental casts. Evaluation of the treatment results was measured on these models and using finite element scaling analysis (FESA). An Angle Class I relationship was obtained after 2½ years of treatment, function and facial aesthetics were improved. The shape of the palate changed significant in the width direction, not significantly in length and high direction. The greatest expansion of palate was found in the region between the palatal cusps of the first molars 26.6%, followed by first 21.9% and second premolars 16.5%. SARME in adult patients with bilateral cross bite and maxillary deficiency lead to satisfactory results. The 3D laser scanned models and their measurements, using advanced software's are successfully used for precise studies.

  20. Towards a functional neuroanatomy of conscious perception and its modulation by volition: implications of human auditory neuroimaging studies.

    PubMed Central

    Silbersweig, D A; Stern, E

    1998-01-01

    Conscious sensory perception and its modulation by volition are integral to human mental life. Functional neuroimaging techniques provide a direct means of identifying and characterizing in vivo the systems-level patterns of brain activity associated with such mental functions. In a series of positron emission tomography activation experiments, we and our colleagues have examined a range of normal and abnormal auditory states that, when contrasted, provide dissociations relevant to the question of the neural substrates of sensory awareness. These dissociations include sensory awareness in the presence and absence of external sensory stimuli, the transition from sensory unawareness to awareness (or vice versa) in the presence of sensory stimuli, and sensory awareness with and without volition. The auditory states studied include hallucinations, mental imagery, cortical deafness modulated by attention, and hearing modulated by sedation. The results of these studies highlight the distributed nature of the functional neuroanatomy that is sufficient, if not necessary, for sensory awareness. The probable roles of unimodal association (as compared with primary) cortices, heteromodal cortices, limbic/paralimbic regions and subcortical structures (such as the thalamus) are discussed. In addition, interactions between pre- and post-rolandic regions are examined in the context of top-down, volitional modulation of sensory awareness. PMID:9854260

  1. The Five Factors of personality and regional cortical variability in the Baltimore Longitudinal Study of Aging

    PubMed Central

    Sutin, Angelina; Davatzikos, Christos; Costa, Paul; Resnick, Susan

    2012-01-01

    Although personality changes have been associated with brain lesions and atrophy caused by neurodegenerative diseases and aging, neuroanatomical correlates of personality in healthy individuals and their stability over time have received relatively little investigation. In this study, we explored regional gray matter (GM) volumetric associations of the five-factor model of personality. Eighty-seven healthy older adults took the NEO Personality Inventory and had brain MRI at two time points 2 years apart. We performed GM segmentation followed by regional analysis of volumes examined in normalized space map creation and voxel based morphometry-type statistical inference in SPM8. We created a regression model including all five factors and important covariates. Next, a conjunction analysis identified associations between personality scores and GM volumes that were replicable across time, also using cluster-level Family-Wise-Error correction. Larger right orbitofrontal and dorsolateral prefrontal cortices and rolandic operculum were associated with lower Neuroticism; larger left temporal, dorsolateral prefrontal, and anterior cingulate cortices with higher Extraversion; larger right frontopolar and smaller orbitofrontal and insular cortices with higher Openness; larger right orbitofrontal cortex with higher Agreeableness; larger dorsolateral prefrontal and smaller frontopolar cortices with higher Conscientiousness. In summary, distinct personality traits were associated with stable individual differences in GM volumes. As expected for higher-order traits, regions performing a large number of cognitive and affective functions were implicated. Our findings highlight personality-related variation that may be related to individual differences in brain structure that merit additional attention in neuroimaging research. PMID:22610513

  2. Statistical design of a uranium corrosion experiment

    SciTech Connect

    Wendelberger, Joanne R; Moore, Leslie M

    2009-01-01

    This work supports an experiment being conducted by Roland Schulze and Mary Ann Hill to study hydride formation, one of the most important forms of corrosion observed in uranium and uranium alloys. The study goals and objectives are described in Schulze and Hill (2008), and the work described here focuses on development of a statistical experiment plan being used for the study. The results of this study will contribute to the development of a uranium hydriding model for use in lifetime prediction models. A parametric study of the effect of hydrogen pressure, gap size and abrasion on hydride initiation and growth is being planned where results can be analyzed statistically to determine individual effects as well as multi-variable interactions. Input to ESC from this experiment will include expected hydride nucleation, size, distribution, and volume on various uranium surface situations (geometry) as a function of age. This study will also address the effect of hydrogen threshold pressure on corrosion nucleation and the effect of oxide abrasion/breach on hydriding processes. Statistical experiment plans provide for efficient collection of data that aids in understanding the impact of specific experiment factors on initiation and growth of corrosion. The experiment planning methods used here also allow for robust data collection accommodating other sources of variation such as the density of inclusions, assumed to vary linearly along the cast rods from which samples are obtained.

  3. Human annoyance and reactions to hotel room specific noises

    NASA Astrophysics Data System (ADS)

    Everhard, Ian L.

    2004-05-01

    A new formula is presented where multiple annoyance sources and transmission loss values of any partition are combined to produce a new single number rating of annoyance. The explanation of the formula is based on theoretical psychoacoustics and survey testing used to create variables used to weight the results. An imaginary hotel room is processed through the new formula and is rated based on theoretical survey results that would be taken by guests of the hotel. The new single number rating compares the multiple sources of annoyance to a single imaginary unbiased source where absolute level is the only factor in stimulating a linear rise in annoyance [Fidell et al., J. Acoust. Soc. Am. 66, 1427 (1979); D. M. Jones and D. E. Broadbent, ``Human performance and noise,'' in Handbook of Noise Control, 3rd ed., edited by C. M. Harris (ASA, New York, 1998), Chap. 24; J. P. Conroy and J. S. Roland, ``STC Field Testing and Results,'' in Sound and Vibration Magazine, Acoustical Publications, pp. 10-15 (July 2003)].

  4. Identification of Human Gustatory Cortex by Activation Likelihood Estimation

    PubMed Central

    Veldhuizen, Maria G.; Albrecht, Jessica; Zelano, Christina; Boesveldt, Sanne; Breslin, Paul; Lundström, Johan N.

    2010-01-01

    Over the last two decades, neuroimaging methods have identified a variety of taste-responsive brain regions. Their precise location, however, remains in dispute. For example, taste stimulation activates areas throughout the insula and overlying operculum, but identification of subregions has been inconsistent. Furthermore, literature reviews and summaries of gustatory brain activations tend to reiterate rather than resolve this ambiguity. Here we used a new meta-analytic method [activation likelihood estimation (ALE)] to obtain a probability map of the location of gustatory brain activation across fourteen studies. The map of activation likelihood values can also serve as a source of independent coordinates for future region-of-interest analyses. We observed significant cortical activation probabilities in: bilateral anterior insula and overlying frontal operculum, bilateral mid dorsal insula and overlying Rolandic operculum, and bilateral posterior insula/parietal operculum/postcentral gyrus, left lateral orbitofrontal cortex (OFC), right medial OFC, pregenual anterior cingulate cortex (prACC) and right mediodorsal thalamus. This analysis confirms the involvement of multiple cortical areas within insula and overlying operculum in gustatory processing and provides a functional “taste map” which can be used as an inclusive mask in the data analyses of future studies. In light of this new analysis, we discuss human central processing of gustatory stimuli and identify topics where increased research effort is warranted. PMID:21305668

  5. Comparison between Kinesio Taping and a Traditional Physical Therapy Program in Treatment of Nonspecific Low Back Pain.

    PubMed

    Kachanathu, Shaji John; Alenazi, Aqeel M; Seif, Hamada Eid; Hafez, Ashraf Ramadan; Alroumim, Meshari Abdulmohsen

    2014-08-01

    [Purpose] Nonspecific low back pain (NSLBP) is a very common but largely self-limiting condition. Several types of tape and their associated application methods are available for different conditions. The aim of the present study was to observe the effect of Kinesio taping (KT) compared with traditional management of NSLBP. [Subjects and Methods] Forty male and female patients with a mean age of 34.8±7.54 years were randomly divided into two groups; group 1 (n=20) which underwent conventional physical therapy with KT, and group 2 (n=20), which underwent only conventional physical therapy. The intervention sessions for both groups were three times per week for four weeks. Outcomes were assessed for activities of daily living (ADL) using the Roland-Morris Disability Questionnaire, pain severity using a visual analogue scale, and ranges of motion (ROMs) of trunk flexion and extension using the modified Schober's test. [Results] Significant differences in measures of pain, ADL, and trunk flexion and extension ROMs were observed post intervention within each group. In comparison, there were no significant differences in measures of pain, ADL, and trunk flexion and extension ROMs post intervention between groups. [Conclusion] A physical therapy program involving strengthening exercises for abdominal muscles and stretching exercises for back, hamstring, and iliopsoas muscles with or without Kinesio taping was beneficial in the treatment of chronic low back pain.

  6. [The Brazilian version of the Fear Avoidance Beliefs Questionnaire].

    PubMed

    Abreu, Ana Maria de; Faria, Christina Danielli Coelho de Morais; Cardoso, Sônia Maria Vicente; Teixeira-Salmela, Luci Fuscaldi

    2008-03-01

    The aim of the present study was to investigate the psychometric properties and validate the Portuguese version of the Fear Avoidance Beliefs Questionnaire (FABQ-Brazil). This instrument assesses how beliefs and fear of individuals with lower back pain affect two subscales related to their physical activities (FABQ-Phys) and work (FABQ-Work). The questionnaire was translated into Brazilian Portuguese, following the recommended methodology, and applied to 53 individuals with non-specific chronic lower back pain. The test-retest intra-class correlation coefficients (ICC = 0.84 and 0.91) and the internal consistency (Cronbach's = 0.80 and 0.90) for FABQ-Phys and FABQ-Work, respectively, were acceptable. The stepwise multiple regression analyses revealed statistically significant correlations between all isolated items with their respective subscales, and the set of the items explained 99% of the changes in scores for each subscale. No significant correlations were found between the subscales; however, both the FABQ-Phys and FABQ-Work subscales were positively associated with pain intensity (visual numerical scale) and degree of disability (Roland Morris Questionnaire). These findings supported the evidence that the FABQ-Brazil showed adequate psychometric properties for individuals with chronic lower back pain.

  7. Elcatonin in combination with risedronate is more effective than risedronate alone for relieving back pain in postmenopausal women with osteoporosis.

    PubMed

    Takakuwa, Masayuki; Iwamoto, Jun

    2012-01-01

    Intramuscularly administered elcatonin (ECT) reduces pain via the central nervous system. A prospective study was performed to determine whether ECT has a beneficial effect on back pain and function in postmenopausal women with osteoporosis during bisphosphonate therapy. Sixty-one postmenopausal osteoporotic women with back pain (mean age: 73.7 years, range: 54-96 years) were divided into two groups: the control group (n=30) and the ECT (intramuscular, 20 units a week) group (n=31). All patients received treatment with risedronate (17.5 mg weekly). The duration of the study was 8 weeks. Urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX), visual analogue scale (VAS) for back pain at rest and movement, and Roland-Morris Disability Questionnaire (RDQ) score for function were assessed. Urinary NTX levels, VAS at rest and movement, and RDQ score markedly decreased during 8 weeks of treatment in both ECT and control groups. A significant reduction in VAS at movement, but not in VAS at rest and RDQ score, was noted in the ECT group than in the control group. This effect was observed from 2 weeks after the start of therapy. These results suggested that ECT in combination with risedronate was more effective than risedronate alone for reducing back pain in postmenopausal women with osteoporosis.

  8. Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures.

    PubMed

    Ohtori, Seiji; Akazawa, Tsutomu; Murata, Yasuaki; Kinoshita, Tomoaki; Yamashita, Masaomi; Nakagawa, Koichi; Inoue, Gen; Nakamura, Junichi; Orita, Sumihisa; Ochiai, Nobuyasu; Kishida, Shunji; Takaso, Masashi; Eguchi, Yawara; Yamauchi, Kazuyo; Suzuki, Munetaka; Aoki, Yasuchika; Takahashi, Kazuhisa

    2010-02-01

    Elderly postmenopausal women who have osteoporosis sometimes experience low back pain, however, the relationship between low back pain and osteoporosis in the absence of vertebral fractures remains unclear. We examined the relationship between bone mineral density (BMD), bone resorption and low back pain in elderly female patients who did not have osteoporotic vertebral fractures. The average BMD was 0.675 g/cm(2) when assessed by dual-energy X-ray absorptiometry (DEXA). Patients were excluded from the study if they had vertebral fractures revealed by radiography, CT scans or MRI. Bisphosphonate (risedronate) was administered for 4 months. The visual analogue scale (VAS) pain score, Roland Morris Disability Questionnaire (RDQ), Short Form-36 (SF-36) questionnaire, BMD and N-terminal telopeptide of type I collagen (NTx; a marker for bone resorption) were examined before and after treatment. DEXA did not increase significantly, but serum and urinary NTx were decreased (-51.4% and -62.0%, respectively) after 4 months of risedronate treatment (p<0.01). The assessment was repeated using the VAS score, RDQ and SF-36, which revealed an improvement after risedronate treatment (p<0.01). A decrease in serum and urinary NTx was associated with improvement of low back pain, suggesting that despite the absence of vertebral fractures, bone resorption due to osteoporosis may cause low back pain.

  9. Map Showing Principal Coal Beds and Bedrock Geology of the Ucross-Arvada Area, Central Powder River Basin, Wyoming

    USGS Publications Warehouse

    Molnia, Carol L.

    2013-01-01

    The Ucross-Arvada area is part of the Powder River Basin, a large, north-trending structural depression between the Black Hills on the east and the Bighorn Mountains on the west. Almost all of the study area is within Sheridan and Johnson Counties, Wyoming. Most of the Ucross-Arvada area lies within the outcrop of the Wasatch Formation of Eocene age; the extreme northeast corner falls within the outcrop of the Tongue River Member of the Fort Union Formation of Paleocene age. Within the Powder River Basin, both the Wasatch Formation and the Tongue River Member of the Fort Union Formation contain significant coal resources. The map includes locations and elevations of coal beds at 1:50,000 scale for an area that includes ten 7½-minute quadrangles covering some 500 square miles. The Wasatch Formation coal beds shown (in descending order) are Monument Peak, Walters (also called Ulm 1), Healy (also called Ulm 2), Truman, Felix, and Arvada. The Fort Union Formation coal beds shown (in descending order) are Roland (of Baker, 1929) and Smith.

  10. Dipole versus distributed EEG source localization for single versus averaged spikes in focal epilepsy.

    PubMed

    Plummer, C; Wagner, M; Fuchs, M; Harvey, A S; Cook, M J

    2010-06-01

    The aim of this study is to characterize and compare dipole and distributed EEG source localization (ESL) of interictal epileptiform discharges (IEDs) in focal epilepsy. Single and averaged scalp IEDs from eight patients-four with benign focal epilepsy of childhood with centrotemporal spikes (BFEC) and four with mesial temporal lobe epilepsy (MTLE)-underwent independent component analysis (ICA) from IED onset to peak. The boundary element method forward model was applied to one of four inverse models: two dipolar-moving regularized, rotating nonregularized and two distributed-standardized low-resolution electromagnetic tomography with rotating cortical sources or with fixed extended sources. Solutions were studied at IED onset, midupswing, peak; ESL strength maxima; ESL residual deviation minima (best fit). From 11,040 ESL parameter points and 960 ESL maps, best-fit dipole and distributed solutions fell at the IED midupswing in BFEC and MTLE when the dominant ICA component typically peaked, localizing to the lower Rolandic sulcus in BFEC and to basolateral or anterior temporal cortex in MTLE. Single-to-averaged ESL variability was high in MTLE. Dipole and distributed ESL are complementary; best-fit solutions for both occupy the IED midupswing and not the IED peak. ICA, a "blind" statistical operation, aids clinical interpretation of ESL fit quality. Single-to-averaged IED localization discordance can be high, a problem warranting further scrutiny if ESL is to earn a place in routine epilepsy care.

  11. Work-Related Low Back Pain Treatment: A Randomized Controlled Trial from Tehran, Iran, Comparing Multidisciplinary Educational Program versus Physiotherapy Education

    PubMed Central

    Ghadyani, Leila; Kazemnejad, Anoshirvan; Wagner, Joan

    2016-01-01

    Study Design Clinical trial. Purpose To compare the multidisciplinary educational program versus physiotherapy education among Iranian nurses. Overview of Literature Low back pain (LBP) can accompany significant occupational injuries in the nursing profession. There is no agreement on the most effective educational practice. Methods This study was conducted from August 17, 2014 to September 22, 2014 in Tehran, Iran. Eligible nurses with chronic mechanical LBP (n=136) were classified into an intervention group (n=66) or the control group (n=70). The intervention group received physiotherapy education for 120-minutes followed by a 120-minute health education session based on predictive constructs of social cognitive theory (SCT). The control group received the 120-minute physiotherapy education. Disability rate, pain severity and back pain prevention behavior were measured at initially and 3 months after intervention using visual analogue scale, Roland-Morris disability questionnaire and nursing low back pain preventive behaviors questionnaire. Results The two groups were the same in terms of all studied variables at the initiation of the study. At the 3-month follow up, predictive constructs of LBP preventive behaviors of participants in the intervention were improved (p<0.001). Significant decreases were evident at 3 months in pain severity (p=0.03) and disability (p=0.003). Conclusions The designed multidisciplinary educational intervention could decrease chronic mechanical LBP in nurses. PMID:27559449

  12. Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.

    PubMed

    Spencer, John; Coaker, Hannah

    2015-01-01

    The SelectBio 2015: Academic Drug Discovery Conference was held in Cambridge, UK, on 19-20 May 2015. Building on the success of academic drug discovery events in the USA, this conference aimed to showcase the exciting new research emerging from academic drug discovery and to help bridge the gap between basic research and commercial application. At the event the authors heard from a number of speakers on a broad array of topics, from partnering models for academia and industry to novel drug discovery approaches across various therapeutic areas, with a few talks, such as those by Susanne Muller-Knapp (Structure Genomics Consortium, Oxford University, Oxford, UK) and Julian Blagg (Institute of Cancer Research, UK), covering both remits, by highlighting a number of such partnerships and then delving into some case studies. The conference concluded with a heated debate on whether phenotypic discovery should be favored over targeted discovery in academia and pharma, in a panel discussion chaired by Roland Wolkowicz (San Diego State University, USA).

  13. ACRIDINE ORANGE BINDING BY MICROCOCCUS LYSODEIKTICUS

    PubMed Central

    Beers, Roland F.

    1964-01-01

    Beers, Roland F., Jr. (Johns Hopkins University, Baltimore, Md). Acridine orange binding by Micrococcus lysodeikticus. J. Bacteriol. 88:1249–1256. 1964.—Micrococcus lysodeikticus cells bind acridine orange (AO) reversibly. The adsorption isotherm is consistent with a highly cooperative-type binding similar to that observed with polyadenylic acid. The cells exhibit a strong buffering action on the concentration of free AO which remains constant (1 μg/ml) over a range from 5 to 95% saturation of the cells by AO. The cells stain either fluorescent orange or green. The fraction stained orange is directly proportional to the quantity of dye adsorbed, indicating that these cells bind a fixed amount of AO (10% of dry weight). The green-stained cells contain less than 1% of the AO bound to orange-stained cells. The results suggest that the abrupt increase in amount of AO bound by the orange-stained cells occurs when the concentration of free AO reaches a threshold concentration. Similar results were obtained with Bacillus cereus. Mg increases the free AO concentration and the extent of binding capacity of the cells. PMID:14234778

  14. Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain.

    PubMed

    Gimbel, Joseph S; Kivitz, Alan J; Bramson, Candace; Nemeth, Mary Anne; Keller, David S; Brown, Mark T; West, Christine R; Verburg, Kenneth M

    2014-09-01

    A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg (n=527) administered at 8-week intervals via 3 intravenous injections followed by 4 subcutaneous injections. Effectiveness analyses included change from parent study baseline in Brief Pain Inventory Short Form, Roland Morris Disability Questionnaire, and Patient's Global Assessment of low back pain. Safety assessments included adverse event documentation, physical/neurological examinations, and laboratory tests. Mean treatment duration during the extension study was 194 and 202 days with tanezumab 10 and 20mg, respectively. Both tanezumab doses provided similar and sustained improvements in all effectiveness outcomes. The most frequently reported adverse events were arthralgia, paresthesia, and hypoesthesia. Adverse events initially described as osteonecrosis were reported in 6 patients (tanezumab 10mg, n=2; tanezumab 20mg, n=4); 9 additional patients (tanezumab 10mg, n=7; tanezumab 20mg, n=2) underwent total joint replacement (TJR). A blinded, independent adjudication committee reviewed all 6 patients with reported osteonecrosis and 4 of the 9 patients undergoing TJR. Adjudication outcomes were osteonecrosis (n=0), worsening osteoarthritis (n=5; 1 rapidly progressive), and another diagnosis or indeterminate (n=5). Tanezumab 10mg had better tolerability than tanezumab 20mg, and may represent an effective long-term treatment for chronic low back pain.

  15. Conference scene: DGVS spring conference 2009.

    PubMed

    Kolligs, Frank Thomas

    2009-10-01

    The 3rd annual DGVS Spring Conference of the German Society for Gastroenterology (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten) was held at the Seminaris Campus Hotel in Berlin, Germany, on 8-9 May, 2009. The conference was organized by Roland Schmid and Matthias Ebert from the Technical University of Munich, Germany. The central theme of the meeting was 'translational gastrointestinal oncology: towards personalized medicine and individualized therapy'. The conference covered talks on markers for diagnosis, screening and surveillance of colorectal cancer, targets for molecular therapy, response prediction in clinical oncology, development and integration of molecular imaging in gastrointestinal oncology and translational research in clinical trial design. Owing to the broad array of topics and limitations of space, this article will focus on biomarkers, response prediction and the integration of biomarkers into clinical trials. Presentations mentioned in this summary were given by Matthias Ebert (Technical University of Munich, Germany), Esmeralda Heiden (Epigenomics, Berlin, Germany), Frank Kolligs (University of Munich, Germany), Florian Lordick (University of Heidelberg, Germany), Hans Jorgen Nielsen (University of Copenhagen, Denmark), Anke Reinacher-Schick (University of Bochum, Germany), Christoph Röcken (University of Berlin, Germany), Wolff Schmiegel (University of Bochum, Germany) and Thomas Seufferlein (University of Halle, Germany).

  16. Nonoperatively treated type A spinal fractures: mid-term versus long-term functional outcome.

    PubMed

    Post, R B; van der Sluis, C K; Leferink, V J M; Dijkstra, P U; ten Duis, H J

    2009-08-01

    This study focuses on the mid-term (four years) and long-term (ten years) functional outcome of patients treated nonoperatively for a type A spinal fracture without primary neurological deficit. Functional outcome was measured using the visual analogue scale spine score (VAS) and the Roland-Morris disability questionnaire (RMDQ). The 50 patients included were on average 41.2 years old at the time of injury. Four years post injury, a mean VAS score of 74.5 and a mean RMDQ score of 4.9 were found. Ten years after the accident, the mean VAS and RMDQ scores were 72.6 and 4.7, respectively (NS). No significant relationships were found between the difference scores of the VAS and RMDQ compared with age, gender, fracture sub-classification, and time between measurements. Three (6%) patients had a poor long-term outcome. None of the patients required surgery for late onset pain or progressive neurological deficit. Functional outcome after a nonoperatively treated type A spinal fracture is good, both four and ten years post injury. For the group as a whole, four years after the fracture a steady state exists in functional outcome, which does not change for ten years at least after the fracture.

  17. Chronotype predicts activity patterns in the neural underpinnings of the motor system during the day.

    PubMed

    Peres, Isabella; Vetter, Céline; Blautzik, Janusch; Reiser, Maximilian; Pöppel, Ernst; Meindl, Thomas; Roenneberg, Till; Gutyrchik, Evgeny

    2011-12-01

    Neuroimaging is increasingly used to study the motor system in vivo. Despite many reports of time-of-day influences on motor function at the behavioral level, little is known about these influences on neural motor networks and their activations recorded in neuroimaging. Using functional magnetic resonance imaging (fMRI), the authors studied 15 healthy subjects (9 females; mean ± SD age: 23 ± 3 yrs) performing a self-paced finger-tapping task at different times of day (morning, midday, afternoon, and evening). Blood-oxygenation-level-dependent signal showed systematic differences across the day in task-related motor areas of the brain, specifically in the supplementary motor area, parietal cortex, and rolandic operculum (p(corr)< .0125). The authors found that these time-of-day-dependent hemodynamic modulations are associated with chronotype and not with homeostatic sleep pressure. These results show that consideration of time-of-day for the analysis of fMRI studies is imperative.

  18. Altered gray matter organization in children and adolescents with ADHD: a structural covariance connectome study.

    PubMed

    Griffiths, K R; Grieve, S M; Kohn, M R; Clarke, S; Williams, L M; Korgaonkar, M S

    2016-11-08

    Although multiple studies have reported structural deficits in multiple brain regions in attention-deficit hyperactivity disorder (ADHD), we do not yet know if these deficits reflect a more systematic disruption to the anatomical organization of large-scale brain networks. Here we used a graph theoretical approach to quantify anatomical organization in children and adolescents with ADHD. We generated anatomical networks based on covariance of gray matter volumes from 92 regions across the brain in children and adolescents with ADHD (n=34) and age- and sex-matched healthy controls (n=28). Using graph theory, we computed metrics that characterize both the global organization of anatomical networks (interconnectivity (clustering), integration (path length) and balance of global integration and localized segregation (small-worldness)) and their local nodal measures (participation (degree) and interaction (betweenness) within a network). Relative to Controls, ADHD participants exhibited altered global organization reflected in more clustering or network segregation. Locally, nodal degree and betweenness were increased in the subcortical amygdalae in ADHD, but reduced in cortical nodes in the anterior cingulate, posterior cingulate, mid temporal pole and rolandic operculum. In ADHD, anatomical networks were disrupted and reflected an emphasis on subcortical local connections centered around the amygdala, at the expense of cortical organization. Brains of children and adolescents with ADHD may be anatomically configured to respond impulsively to the automatic significance of stimulus input without having the neural organization to regulate and inhibit these responses. These findings provide a novel addition to our current understanding of the ADHD connectome.

  19. Intelligence-related differences in the asymmetry of spontaneous cerebral activity.

    PubMed

    Santarnecchi, Emiliano; Tatti, Elisa; Rossi, Simone; Serino, Vinicio; Rossi, Alessandro

    2015-09-01

    Recent evidence suggests the spontaneous BOLD signal synchronization of corresponding interhemispheric, homotopic regions as a stable trait of human brain physiology, with emerging differences in such organization being also related to some pathological conditions. To understand whether such brain functional symmetries play a role into higher-order cognitive functioning, here we correlated the functional homotopy profiles of 119 healthy subjects with their intelligence level. Counterintuitively, reduced homotopic connectivity in above average-IQ versus average-IQ subjects was observed, with significant reductions in visual and somatosensory cortices, supplementary motor area, rolandic operculum, and middle temporal gyrus, possibly suggesting that a downgrading of interhemispheric talk at rest could be associated with higher cognitive functioning. These regions also showed an increased spontaneous synchrony with medial structures located in ipsi- and contralateral hemispheres, with such pattern being mostly detectable for regions placed in the left hemisphere. The interactions with age and gender have been also tested, with different patterns for subjects above and below 25 years old and less homotopic connectivity in the prefrontal cortex and posterior midline regions in female participants with higher IQ scores. These findings support prior evidence suggesting a functional role for homotopic connectivity in human cognitive expression, promoting the reduction of synchrony between primary sensory regions as a predictor of higher intelligence levels.

  20. PREFACE: International Conference "Trends in Spintronics and Nanomagnetism" (TSN-2010)

    NASA Astrophysics Data System (ADS)

    Maruccio, Giuseppe; Sanvito, Stefano; Hoffmann, Germar; Wiesendanger, Roland; Rowan, Alan

    2011-03-01

    Dublin, Ireland), Germar Hoffmann and Roland Wiesendanger (Institute for Applied Physics, University of Hamburg, Germany), and Alan Rowan (NSRIM Institute Radboud University Nijmegen, The Netherlands). This group also acted as the Publication Committee and managed all the submitted papers that were reviewed by expert referees in order to meet the standards of the Journal of Physics: Conference Series. Conference photographNobel Laureate A Fert with some members of the organizing committee. The conference would not have been possible without the support from the local organizing committee at the University of Salento and NNL Institute Nanoscience-CNR, including Anna Paola Caricato, Luigi Martina and the Conference Secretaries Maria Concetta Gerardi, Adriana Amato, and Gabriella Zammillo. We are grateful for the technical assistance of Michele Linciano, Antonio Guerrieri, Carmine Mangia, Luciano Carluccio, and Tommaso Moscara e Francesco Sabetta. We also gratefully acknowledge Serena Chiriacó, Anna Grazia Mondeduro and Massimo Corrado who helped to run the conference. The conference was made possible by the financial support from the European Commission through the SpiDME project (EU-FP6-029002), the Italian Ministry for Foreign Affairs, the University of Lecce and its Department of Physics, and all of the sponsors (Lot Oriel, Attocube, Schaefer, Cryogenic Ltd, Oxford Instruments, MTI Corporation, Cantele, Monte dei Paschi di Siena). Conference Chair and Co-Chairs Giuseppe MaruccioStefano SanvitoGermar HoffmannRoland WiesendangerAlan Rowan Logos

  1. Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses.

    PubMed

    Jones, Stephanie R; Pritchett, Dominique L; Sikora, Michael A; Stufflebeam, Steven M; Hämäläinen, Matti; Moore, Christopher I

    2009-12-01

    Variations in cortical oscillations in the alpha (7-14 Hz) and beta (15-29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its prominence, the neural mechanisms regulating mu are unknown. We characterized the ongoing MEG mu rhythm from a localized source in the finger representation of primary somatosensory (SI) cortex. Subjects showed variation in the relative expression of mu-alpha or mu-beta, which were nonoverlapping for roughly 50% of their respective durations on single trials. To delineate the origins of this rhythm, a biophysically principled computational neural model of SI was developed, with distinct laminae, inhibitory and excitatory neurons, and feedforward (FF, representative of lemniscal thalamic drive) and feedback (FB, representative of higher-order cortical drive or input from nonlemniscal thalamic nuclei) inputs defined by the laminar location of their postsynaptic effects. The mu-alpha component was accurately modeled by rhythmic FF input at approximately 10-Hz. The mu-beta component was accurately modeled by the addition of approximately 10-Hz FB input that was nearly synchronous with the FF input. The relative dominance of these two frequencies depended on the delay between FF and FB drives, their relative input strengths, and stochastic changes in these variables. The model also reproduced key features of the impact of high prestimulus mu power on peaks in SI-evoked activity. For stimuli presented during high mu power, the model predicted enhancement in an initial evoked peak and decreased subsequent deflections. In agreement, the MEG-evoked responses showed an enhanced initial peak and a trend to smaller subsequent peaks. These data provide new information on the dynamics of the mu rhythm in humans and the model provides a novel mechanistic

  2. Quantitative Analysis and Biophysically Realistic Neural Modeling of the MEG Mu Rhythm: Rhythmogenesis and Modulation of Sensory-Evoked Responses

    PubMed Central

    Pritchett, Dominique L.; Sikora, Michael A.; Stufflebeam, Steven M.; Hämäläinen, Matti; Moore, Christopher I.

    2009-01-01

    Variations in cortical oscillations in the alpha (7–14 Hz) and beta (15–29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its prominence, the neural mechanisms regulating mu are unknown. We characterized the ongoing MEG mu rhythm from a localized source in the finger representation of primary somatosensory (SI) cortex. Subjects showed variation in the relative expression of mu-alpha or mu-beta, which were nonoverlapping for roughly 50% of their respective durations on single trials. To delineate the origins of this rhythm, a biophysically principled computational neural model of SI was developed, with distinct laminae, inhibitory and excitatory neurons, and feedforward (FF, representative of lemniscal thalamic drive) and feedback (FB, representative of higher-order cortical drive or input from nonlemniscal thalamic nuclei) inputs defined by the laminar location of their postsynaptic effects. The mu-alpha component was accurately modeled by rhythmic FF input at approximately 10-Hz. The mu-beta component was accurately modeled by the addition of approximately 10-Hz FB input that was nearly synchronous with the FF input. The relative dominance of these two frequencies depended on the delay between FF and FB drives, their relative input strengths, and stochastic changes in these variables. The model also reproduced key features of the impact of high prestimulus mu power on peaks in SI-evoked activity. For stimuli presented during high mu power, the model predicted enhancement in an initial evoked peak and decreased subsequent deflections. In agreement, the MEG-evoked responses showed an enhanced initial peak and a trend to smaller subsequent peaks. These data provide new information on the dynamics of the mu rhythm in humans and the model provides a novel mechanistic

  3. The Deepwater Horizon Disaster: What Happened and Why

    SciTech Connect

    Horne, Roland N.

    2011-01-05

    The Deepwater Horizon disaster was the largest oil spill in US history, and the second largest spill in the world. 11 men lost their lives in the explosion and fire. Although the impacts of the spill were evident to large numbers of people, its causes were harder to see. This lecture will focus on the technical aspects of the events that led to the spill itself: what happened on the rig before, during and after the event, up to the time the rig sank. As with many engineering disasters, the accident was due to a sequence of failures, including both technical systems and procedural issues. Although the causes were complex and interacting, the lecture will focus on four main problems: (1) the failure of the cement and casing seal, (2) the failure to recognize and respond to hydrocarbon flow into the riser, (3) the ignition of hydrocarbons on the rig, and (4) the failure of the blow-out preventer (BOP) to seal the well. The lecture will conclude with some suggestions as to how events such as the Deepwater Horizon disaster can be avoided in the future. (Roland N. Horne is the Thomas Davies Barrow Professor of Earth Sciences at Stanford University, and was the Chairman of Petroleum Engineering from 1995 to 2006. He holds BE, PhD and DSc degrees from the University of Auckland, New Zealand, all in Engineering Science. Horne is a member of the U.S. National Academy of Engineering and is also an Honorary Member of the Society of Petroleum Engineers.)

  4. The importance of synchrony and temporal order of visual and tactile input for illusory limb ownership experiences - an FMRI study applying virtual reality.

    PubMed

    Bekrater-Bodmann, Robin; Foell, Jens; Diers, Martin; Kamping, Sandra; Rance, Mariela; Kirsch, Pinar; Trojan, Jörg; Fuchs, Xaver; Bach, Felix; Çakmak, Hüseyin Kemal; Maaß, Heiko; Flor, Herta

    2014-01-01

    In the so-called rubber hand illusion, synchronous visuotactile stimulation of a visible rubber hand together with one's own hidden hand elicits ownership experiences for the artificial limb. Recently, advanced virtual reality setups were developed to induce a virtual hand illusion (VHI). Here, we present functional imaging data from a sample of 25 healthy participants using a new device to induce the VHI in the environment of a magnetic resonance imaging (MRI) system. In order to evaluate the neuronal robustness of the illusion, we varied the degree of synchrony between visual and tactile events in five steps: in two conditions, the tactile stimulation was applied prior to visual stimulation (asynchrony of -300 ms or -600 ms), whereas in another two conditions, the tactile stimulation was applied after visual stimulation (asynchrony of +300 ms or +600 ms). In the fifth condition, tactile and visual stimulation was applied synchronously. On a subjective level, the VHI was successfully induced by synchronous visuotactile stimulation. Asynchronies between visual and tactile input of ±300 ms did not significantly diminish the vividness of illusion, whereas asynchronies of ±600 ms did. The temporal order of visual and tactile stimulation had no effect on VHI vividness. Conjunction analyses of functional MRI data across all conditions revealed significant activation in bilateral ventral premotor cortex (PMv). Further characteristic activation patterns included bilateral activity in the motion-sensitive medial superior temporal area as well as in the bilateral Rolandic operculum, suggesting their involvement in the processing of bodily awareness through the integration of visual and tactile events. A comparison of the VHI-inducing conditions with asynchronous control conditions of ±600 ms yielded significant PMv activity only contralateral to the stimulation site. These results underline the temporal limits of the induction of limb ownership related to multisensory

  5. Twenty-first workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    1996-01-26

    PREFACE The Twenty-First Workshop on Geothermal Reservoir Engineering was held at the Holiday Inn, Palo Alto on January 22-24, 1996. There were one-hundred fifty-five registered participants. Participants came from twenty foreign countries: Argentina, Austria, Canada, Costa Rica, El Salvador, France, Iceland, Indonesia, Italy, Japan, Mexico, The Netherlands, New Zealand, Nicaragua, the Philippines, Romania, Russia, Switzerland, Turkey and the UK. The performance of many geothermal reservoirs outside the United States was described in several of the papers. Professor Roland N. Horne opened the meeting and welcomed visitors. The key note speaker was Marshall Reed, who gave a brief overview of the Department of Energy's current plan. Sixty-six papers were presented in the technical sessions of the workshop. Technical papers were organized into twenty sessions concerning: reservoir assessment, modeling, geology/geochemistry, fracture modeling hot dry rock, geoscience, low enthalpy, injection, well testing, drilling, adsorption and stimulation. Session chairmen were major contributors to the workshop, and we thank: Ben Barker, Bobbie Bishop-Gollan, Tom Box, Jim Combs, John Counsil, Sabodh Garg, Malcolm Grant, Marcel0 Lippmann, Jim Lovekin, John Pritchett, Marshall Reed, Joel Renner, Subir Sanyal, Mike Shook, Alfred Truesdell and Ken Williamson. Jim Lovekin gave the post-dinner speech at the banquet and highlighted the exciting developments in the geothermal field which are taking place worldwide. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank our students who operated the audiovisual equipment. Shaun D. Fitzgerald Program Manager.

  6. Losing it.

    PubMed

    Coutu, Diane L

    2004-04-01

    "It's worse than I thought.... She's completely lost her mind," says Harry Beecham, the CEO of blue chip management consultancy Pierce and Company. The perplexed executive was in a hotel suite with his wife in Amsterdam, the latest stop on his regular trek to dozens of Pierce offices worldwide. In his hand was a sheaf of paper--the same message sent over and over again by his star employee and protégée Katharina Waldburg. The end of the world is coming, she warned. "Someone is going to die." Harry wouldn't have expected this sort of behavior from Katharina. After graduating with distinction from Oxford, she made a name for herself by single-handedly building Pierce's organizational behavior practice. At 27, she's poised to become the youngest partner ever elected at the firm. But Harry can't ignore the faxes in his hand. Or the stream-of-consciousness e-mails Katharina's been sending to one of the directors in Pierce's Berlin office--mostly gibberish but potentially disastrous to Katharina's reputation if they ever got out. Harry also can't dismiss reports from Roland Fuoroli, manager of the Berlin office, of a vicious verbal exchange Katharina had with him, or of an "over the top" lunch date Katharina had with one of Pierce's clients in which she was explaining the alphabet's role in the creation of the universe. Harry is planning to talk to Katharina when he gets to Berlin. What should he say? And will it be too late? Four commentators offer their advice in this fictional case study. They are Kay Redfield Jamison, a professor of psychiatry and a coauthor of Manic-Depressive Illness; David E. Meen, a former director at McKinsey & Company; Norman Pearlstine, the editor in chief at Time Incorporated; and Richard Primus, an assistant law professor at the University of Michigan.

  7. Voxel-Based Morphometry in Individuals at Genetic High Risk for Schizophrenia and Patients with Schizophrenia during Their First Episode of Psychosis

    PubMed Central

    Bai, Chuan; Zhou, Qian; Wei, Shengnan; Jiang, Xiaowei; Geng, Haiyang; Zhou, Yifang; Tang, Yanqing; Wang, Fei

    2016-01-01

    Background Understanding morphologic changes in vulnerable and early disease state of schizophrenia (SZ) may provide further insight into the development of psychosis. Method Whole brain voxel-based morphometry was performed to identify gray matter (GM) regional differences in 60 individuals with SZ during their first psychotic episode (FE-SZ), 31 individuals at genetic high risk for SZ (GHR-SZ) individuals, and 71 healthy controls. Results Significant differences were found in several regions including the prefrontal cortex, parietal lobe, temporal lobe, hippocampus, occipital lobe, and cerebellum among the three groups (p<0.05, corrected). Compared to the HC group, the FE-SZ group had significantly decreased GM volumes in several regions including the cerebellum, hippocampus, fusiform gyrus, lingual gyrus, supramarginal gyrus, and superior, middle, and inferior temporal gyri and significantly increased GM volumes in the middle frontal gyrus and inferior operculum frontal gyrus (p<0.05). The GHR-SZ group had significant decreases in GM volumes in the supramaginal gyrus, precentral gyrus, and rolandic operculum and significant increases in GM volumes in the cerebellum, fusiform gyrus, middle frontal gyrus, inferior operculum frontal gyrus, and superior, middle, and inferior temporal gyri when compared to the HC group (p<0.05). Compared to the GHR-SZ group, the FE-SZ group had significant decreases in GM volumes in several regions including the cerebellum, fusiform gyrus, supramarginal gyrus, and superior, middle, and inferior temporal gyri (p<0.05). Conclusions The findings herein implicate the involvement of multisensory integration in SZ development and pathophysiology. Additionally, the patterns of observed differences suggest possible indicators of disease, vulnerability, and resiliency in SZ. PMID:27723806

  8. Relationship between physical activity and disability in low back pain: a systematic review and meta-analysis.

    PubMed

    Lin, Chung-Wei Christine; McAuley, James H; Macedo, Luciana; Barnett, Dominique C; Smeets, Rob J; Verbunt, Jeanine A

    2011-03-01

    It is often assumed that patients with pain-related disability due to low back pain (LBP) will have reduced physical activity levels, but recent studies have provided results that challenge this assumption. The aim of our systematic review was to examine the relationship between physical activity and disability in LBP. The literature search included 6 electronic databases and the reference list of relevant systematic reviews and studies to May 2010. To be included, studies had to measure both disability (eg, with the Roland Morris Disability Questionnaire) and physical activity (eg, by accelerometry) in patients with non-specific LBP. Two independent reviewers screened search results and extracted data, and authors were contacted for additional data. Correlation coefficients were pooled using the random-effects model. The search identified 3213 records and 18 studies were eligible for inclusion. The pooled results showed a weak relationship between physical activity and disability in acute or subacute (<3months) LBP (r=-0.08, 95% confidence interval=-0.17 to 0.002), and a moderate and negative relationship in chronic (>3months) LBP (r=-0.33, 95% confidence interval=-0.51 to -0.15). That is, persons with acute or subacute LBP appear to vary in the levels of physical activity independent of their pain-related disability. Persons with chronic LBP with high levels of disability are also likely to have low levels of physical activity. Persons with acute or subacute back pain appear to vary in the levels of physical activity independent of disability. Persons with chronic back pain with high levels of disability will likely have low levels of physical activity.

  9. Fixed-point adiabatic quantum search

    NASA Astrophysics Data System (ADS)

    Dalzell, Alexander M.; Yoder, Theodore J.; Chuang, Isaac L.

    2017-01-01

    Fixed-point quantum search algorithms succeed at finding one of M target items among N total items even when the run time of the algorithm is longer than necessary. While the famous Grover's algorithm can search quadratically faster than a classical computer, it lacks the fixed-point property—the fraction of target items must be known precisely to know when to terminate the algorithm. Recently, Yoder, Low, and Chuang [Phys. Rev. Lett. 113, 210501 (2014), 10.1103/PhysRevLett.113.210501] gave an optimal gate-model search algorithm with the fixed-point property. Previously, it had been discovered by Roland and Cerf [Phys. Rev. A 65, 042308 (2002), 10.1103/PhysRevA.65.042308] that an adiabatic quantum algorithm, operating by continuously varying a Hamiltonian, can reproduce the quadratic speedup of gate-model Grover search. We ask, can an adiabatic algorithm also reproduce the fixed-point property? We show that the answer depends on what interpolation schedule is used, so as in the gate model, there are both fixed-point and non-fixed-point versions of adiabatic search, only some of which attain the quadratic quantum speedup. Guided by geometric intuition on the Bloch sphere, we rigorously justify our claims with an explicit upper bound on the error in the adiabatic approximation. We also show that the fixed-point adiabatic search algorithm can be simulated in the gate model with neither loss of the quadratic Grover speedup nor of the fixed-point property. Finally, we discuss natural uses of fixed-point algorithms such as preparation of a relatively prime state and oblivious amplitude amplification.

  10. The use of glucosamine for chronic low back pain: a systematic review of randomised control trials

    PubMed Central

    Sodha, Reena; Sivanadarajah, Naveethan; Alam, Mahbub

    2013-01-01

    Objectives To ascertain whether the use of oral glucosamine influences symptoms or functional outcomes in patients with chronic low back pain (LBP) thought to be related to spinal osteoarthritis (OA). Design Systematic review of randomised control trials. Searches were performed up to March 2011 on Medline, AMED, CINHAL, Cochrane and EMBASE with subsequent reference screening of retrieved studies. In addition, the grey literature was searched via opensigle. Included studies were required to incorporate at least one of the Cochrane Back Pain Review Group's outcome measures as part of their design. Trials with participants over 18 years with a minimum of 12 weeks of back pain, in combination with radiographic changes of OA in the spine, were included. Studies were rated for risk-of-bias and graded for quality. Results 148 studies were identified after screening and meeting eligibility requirements, and three randomised controlled trials (n=309) were included in the quantitative synthesis. The review found that there was low quality but generally no evidence of an effect from glucosamine on function, with no change in the Roland-Morris Disability Questionnaire score in all studies. Conflicting evidence was demonstrated with pain scores with two studies showing no difference and one study with a high risk-of-bias showing both a statistically and clinically significant improvement from taking glucosamine. Conclusions On the basis of the current research, any clinical benefit of oral glucosamine for patients with chronic LBP and radiographic changes of spinal OA can neither be demonstrated nor excluded based on insufficient data and the low quality of existing studies. PMID:23794557

  11. A neuroanatomical model of space-based and object-centered processing in spatial neglect.

    PubMed

    Pedrazzini, Elena; Schnider, Armin; Ptak, Radek

    2017-04-05

    Visual attention can be deployed in space-based or object-centered reference frames. Right-hemisphere damage may lead to distinct deficits of space- or object-based processing, and such dissociations are thought to underlie the heterogeneous nature of spatial neglect. Previous studies have suggested that object-centered processing deficits (such as in copying, reading or line bisection) result from damage to retro-rolandic regions while impaired spatial exploration reflects damage to more anterior regions. However, this evidence is based on small samples and heterogeneous tasks. Here, we tested a theoretical model of neglect that takes in account the space- and object-based processing and relates them to neuroanatomical predictors. One hundred and one right-hemisphere-damaged patients were examined with classic neuropsychological tests and structural brain imaging. Relations between neglect measures and damage to the temporal-parietal junction, intraparietal cortex, insula and middle frontal gyrus were examined with two structural equation models by assuming that object-centered processing (involved in line bisection and single-word reading) and space-based processing (involved in cancelation tasks) either represented a unique latent variable or two distinct variables. Of these two models the latter had better explanatory power. Damage to the intraparietal sulcus was a significant predictor of object-centered, but not space-based processing, while damage to the temporal-parietal junction predicted space-based, but not object-centered processing. Space-based processing and object-centered processing were strongly intercorrelated, indicating that they rely on similar, albeit partly dissociated processes. These findings indicate that object-centered and space-based deficits in neglect are partly independent and result from superior parietal and inferior parietal damage, respectively.

  12. Effect of Mild Thyrotoxicosis on Performance and Brain Activations in a Working Memory Task

    PubMed Central

    Göbel, Anna; Heldmann, Marcus; Göttlich, Martin; Dirk, Anna-Luise; Brabant, Georg; Münte, Thomas F.

    2016-01-01

    Aims Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. The aim of this study was to evaluate effects of mild induced thyrotoxicosis on working memory and its neural correlates. Methods Twenty-nine healthy, male subjects with normal thyroid state participated in the study. Functional MRI was acquired during a working memory task (n-back task) before and after ingesting 250 μg L-thyroxin per day for a period of eight weeks. In addition, neuropsychological tests were performed. Results In the hyperthyroid condition the subjects showed slower reaction times, but a higher accuracy in the 0-back version of the memory tasks. Fewer differences between euthyroid and hyperthyroid state were seen for the more difficult conditions of the n-back task. FMRI revealed effects of difficulty in the parahippocampal gyrus, supplementary motor area, prefrontal cortex, anterior cingulate cortex, posterior cerebellum, rolandic operculum and insula (p<0.05, FWE corrected). When comparing euthyroid and hyperthyroid condition in relation to task-induced activation, differences of activation were found in the right prefrontal cortex as well as in the right parahippocampal area. In the psychological assessment, the alerting effect in the Attention Network Task (ANT) and four out of five parameters of the auditory verbal learning test (AVLT) showed an increase from euthyroid to hyperthyroid state. Conclusions It can be concluded that even a short-term intake of thyroid hormones leads to an activation of brain areas associated with working memory and to an improvement of accuracy of working memory tasks. PMID:27536945

  13. Functional connectivity between brain regions involved in learning words of a new language.

    PubMed

    Veroude, Kim; Norris, David G; Shumskaya, Elena; Gullberg, Marianne; Indefrey, Peter

    2010-04-01

    Previous studies have identified several brain regions that appear to be involved in the acquisition of novel word forms. Standard word-by-word presentation is often used although exposure to a new language normally occurs in a natural, real world situation. In the current experiment we investigated naturalistic language exposure and applied a model-free analysis for hemodynamic-response data. Functional connectivity, temporal correlations between hemodynamic activity of different areas, was assessed during rest before and after presentation of a movie of a weather report in Mandarin Chinese to Dutch participants. We hypothesized that learning of novel words might be associated with stronger functional connectivity of regions that are involved in phonological processing. Participants were divided into two groups, learners and non-learners, based on the scores on a post hoc word recognition task. The learners were able to recognize Chinese target words from the weather report, while the non-learners were not. In the first resting state period, before presentation of the movie, stronger functional connectivity was observed for the learners compared to the non-learners between the left supplementary motor area and the left precentral gyrus as well as the left insula and the left rolandic operculum, regions that are important for phonological rehearsal. After exposure to the weather report, functional connectivity between the left and right supramarginal gyrus was stronger for learners than for non-learners. This is consistent with a role of the left supramarginal gyrus in the storage of phonological forms. These results suggest both pre-existing and learning-induced differences between the two groups.

  14. Vacuum Phenomenon of the Sacroiliac Joint: Correlation with Sacropelvic Morphology

    PubMed Central

    Higashino, Kosaku; Morimoto, Masatoshi; Sakai, Toshinori; Yamashita, Kazuta; Abe, Mitusnobu; Nagamachi, Akihiro; Sairyo, Koichi

    2016-01-01

    Study Design A radiologic study of sacropelvic morphology and vacuum phenomenon of sacroiliac joint in subjects unrelated to low back pain. Purpose The aim of this study is to describe the relationship between sacropelvic morphology and vacuum phenomenon of the sacroiliac joint. Overview of Literature Lumbopelvic alignment and sacropelvic morphology are associated with the pathomechanisms of various spinal disorders. The vacuum phenomena of the sacroiliac joint (SJVP) are often observed in clinical practice, but the relationships between these phenomena and sacropelvic morphology have not been investigated. This study examined the prevalence of SJVP in computed tomography (CT) images and the relationship between sacropelvic morphology and SJVP. Methods We analyzed multiplanar CT images of 93 subjects (59 men, 34 women). Pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), and lumbar lordosis (LL) were measured using the three-dimensional reconstruction method. The prevalence of SJVP in multiplanar CT images were reviewed. Roland-Morris Disability Questionnaire (RDQ) scores and the modified Japanese Orthopedic Association (JOA) score, which focuses on subjective symptoms and restriction of activities of daily living, were also obtained from all the subjects. Results Thirty-six of the 93 subjects had SJVP (39%), with marked female predominance (91% women, 8.5% men). Men with SJVP had significantly lower PI than men without SJVP (35.1° vs. 46.3°, p<0.05). There was no correlation between SJVP and the modified JOA or RDQ scores. Conclusions These data suggest that differences in sacropelvic morphology can influence the biomechanical environment and contribute to SJVP in men. Presence of SJVP did not affect JOA or RDQ scores. PMID:27559459

  15. Diffuse Decreased Gray Matter in Patients with Idiopathic Craniocervical Dystonia: A Voxel-Based Morphometry Study

    PubMed Central

    Piccinin, Camila C.; Piovesana, Luiza G.; Santos, Maria C. A.; Guimarães, Rachel P.; De Campos, Brunno M.; Rezende, Thiago J. R.; Campos, Lidiane S.; Torres, Fabio R.; Amato-Filho, Augusto C.; França, Marcondes C.; Lopes-Cendes, Iscia; Cendes, Fernando; D’Abreu, Anelyssa

    2015-01-01

    Background: Recent studies have addressed the role of structures other than the basal ganglia in the pathophysiology of craniocervical dystonia (CCD). Neuroimaging studies have attempted to identify structural abnormalities in CCD but a clear pattern of alteration has not been established. We performed whole-brain evaluation using voxel-based morphometry (VBM) to identify patterns of gray matter (GM) changes in CCD. Methods: We compared 27 patients with CCD matched in age and gender to 54 healthy controls. VBM was used to compare GM volumes. We created a two-sample t-test corrected for subjects’ age, and we tested with a level of significance of p < 0.001 and false discovery rate (FDR) correction (p < 0.05). Results: Voxel-based morphometry demonstrated significant reductions of GM using p < 0.001 in the cerebellar vermis IV/V, bilaterally in the superior frontal gyrus, precuneus, anterior cingulate and paracingulate, insular cortex, lingual gyrus, and calcarine fissure; in the left hemisphere in the supplementary motor area, inferior frontal gyrus, inferior parietal gyrus, temporal pole, supramarginal gyrus, rolandic operculum, hippocampus, middle occipital gyrus, cerebellar lobules IV/V, superior, and middle temporal gyri; in the right hemisphere, the middle cingulate and precentral gyrus. Our study did not report any significant result using the FDR correction. We also detected correlations between GM volume and age, disease duration, duration of botulinum toxin treatment, and the Marsden–Fahn dystonia scale scores. Conclusion: We detected large clusters of GM changes chiefly in structures primarily involved in sensorimotor integration, motor planning, visuospatial function, and emotional processing. PMID:25620953

  16. Acupuncture in patients with acute low back pain: a multicentre randomised controlled clinical trial.

    PubMed

    Vas, Jorge; Aranda, José Manuel; Modesto, Manuela; Benítez-Parejo, Nicolás; Herrera, Antonia; Martínez-Barquín, Dulce María; Aguilar, Inmaculada; Sánchez-Araujo, Max; Rivas-Ruiz, Francisco

    2012-09-01

    Reviews of the efficacy of acupuncture as a treatment for acute low back pain have concluded that there is insufficient evidence for its efficacy and that more research is needed to evaluate it. A multicentre randomized controlled trial was conducted at 4 primary-care centres in Spain to evaluate the effects of acupuncture in patients with acute nonspecific low back pain in the context of primary care. A total of 275 patients with nonspecific acute low back pain (diagnosed by their general practitioner) were recruited and assigned randomly to 4 different groups: conventional treatment either alone or complemented by 5 sessions over a 2-week period of true acupuncture, sham acupuncture, or placebo acupuncture per patient. Patients were treated from February 2006 to January 2008. The primary outcome was the reduction in Roland Morris Disability Questionnaire scores of 35% or more after 2weeks' treatment. The patients in the 3 types of acupuncture groups were blinded to the treatments, but those who received conventional treatment alone were not. In the analysis adjusted for the total sample (true acupuncture relative risk 5.04, 95% confidence interval 2.24-11.32; sham acupuncture relative risk 5.02, 95% confidence interval 2.26-11.16; placebo acupuncture relative risk 2.57 95% confidence interval 1.21-5.46), as well as for the subsample of occupationally active patients, all 3 modalities of acupuncture were better than conventional treatment alone, but there was no difference among the 3 acupuncture modalities, which implies that true acupuncture is not better than sham or placebo acupuncture.

  17. Yoga for veterans with chronic low back pain: Design and methods of a randomized clinical trial.

    PubMed

    Groessl, Erik J; Schmalzl, Laura; Maiya, Meghan; Liu, Lin; Goodman, Debora; Chang, Douglas G; Wetherell, Julie L; Bormann, Jill E; Atkinson, J Hamp; Baxi, Sunita

    2016-05-01

    Chronic low back pain (CLBP) afflicts millions of people worldwide, with particularly high prevalence in military veterans. Many treatment options exist for CLBP, but most have limited effectiveness and some have significant side effects. In general populations with CLBP, yoga has been shown to improve health outcomes with few side effects. However, yoga has not been adequately studied in military veteran populations. In the current paper we will describe the design and methods of a randomized clinical trial aimed at examining whether yoga can effectively reduce disability and pain in US military veterans with CLBP. A total of 144 US military veterans with CLBP will be randomized to either yoga or a delayed treatment comparison group. The yoga intervention will consist of 2× weekly yoga classes for 12weeks, complemented by regular home practice guided by a manual. The delayed treatment group will receive the same intervention after six months. The primary outcome is the change in back pain-related disability measured with the Roland-Morris Disability Questionnaire at baseline and 12-weeks. Secondary outcomes include pain intensity, pain interference, depression, anxiety, fatigue/energy, quality of life, self-efficacy, sleep quality, and medication usage. Additional process and/or mediational factors will be measured to examine dose response and effect mechanisms. Assessments will be conducted at baseline, 6-weeks, 12-weeks, and 6-months. All randomized participants will be included in intention-to-treat analyses. Study results will provide much needed evidence on the feasibility and effectiveness of yoga as a therapeutic modality for the treatment of CLBP in US military veterans.

  18. Comparing Once- versus Twice-Weekly Yoga Classes for Chronic Low Back Pain in Predominantly Low Income Minorities: A Randomized Dosing Trial.

    PubMed

    Saper, Robert B; Boah, Ama R; Keosaian, Julia; Cerrada, Christian; Weinberg, Janice; Sherman, Karen J

    2013-01-01

    Background. Previous studies have demonstrated that once-weekly yoga classes are effective for chronic low back pain (cLBP) in white adults with high socioeconomic status. The comparative effectiveness of twice-weekly classes and generalizability to racially diverse low income populations are unknown. Methods. We conducted a 12-week randomized, parallel-group, dosing trial for 95 adults recruited from an urban safety-net hospital and five community health centers comparing once-weekly (n = 49) versus twice-weekly (n = 46) standardized yoga classes supplemented by home practice. Primary outcomes were change from baseline to 12 weeks in pain (11-point scale) and back-related function (23-point modified Roland-Morris Disability Questionnaire). Results. 82% of participants were nonwhite; 77% had annual household incomes <$40,000. The sample's baseline mean pain intensity [6.9 (SD 1.6)] and function [13.7 (SD 5.0)] reflected moderate to severe back pain and impairment. Pain and back-related function improved within both groups (P < 0.001). However, there were no differences between once-weekly and twice-weekly groups for pain reduction [-2.1 (95% CI -2.9, -1.3) versus -2.4 (95% CI -3.1, -1.8), P = 0.62] or back-related function [-5.1 (95% CI -7.0, -3.2) versus -4.9 (95% CI -6.5, -3.3), P = 0.83]. Conclusions. Twelve weeks of once-weekly or twice-weekly yoga classes were similarly effective for predominantly low income minority adults with moderate to severe chronic low back pain. This trial is registered with ClinicalTrials.gov NCT01761617.

  19. Spatial variability in cortex-muscle coherence investigated with magnetoencephalography and high-density surface electromyography.

    PubMed

    Piitulainen, Harri; Botter, Alberto; Bourguignon, Mathieu; Jousmäki, Veikko; Hari, Riitta

    2015-11-01

    Cortex-muscle coherence (CMC) reflects coupling between magnetoencephalography (MEG) and surface electromyography (sEMG), being strongest during isometric contraction but absent, for unknown reasons, in some individuals. We used a novel nonmagnetic high-density sEMG (HD-sEMG) electrode grid (36 mm × 12 mm; 60 electrodes separated by 3 mm) to study effects of sEMG recording site, electrode derivation, and rectification on the strength of CMC. Monopolar sEMG from right thenar and 306-channel whole-scalp MEG were recorded from 14 subjects during 4-min isometric thumb abduction. CMC was computed for 60 monopolar, 55 bipolar, and 32 Laplacian HD-sEMG derivations, and two derivations were computed to mimic "macroscopic" monopolar and bipolar sEMG (electrode diameter 9 mm; interelectrode distance 21 mm). With unrectified sEMG, 12 subjects showed statistically significant CMC in 91-95% of the HD-sEMG channels, with maximum coherence at ∼25 Hz. CMC was about a fifth stronger for monopolar than bipolar and Laplacian derivations. Monopolar derivations resulted in most uniform CMC distributions across the thenar and in tightest cortical source clusters in the left rolandic hand area. CMC was 19-27% stronger for HD-sEMG than for "macroscopic" monopolar or bipolar derivations. EMG rectification reduced the CMC peak by a quarter, resulted in a more uniformly distributed CMC across the thenar, and provided more tightly clustered cortical sources than unrectifed sEMGs. Moreover, it revealed CMC at ∼12 Hz. We conclude that HD-sEMG, especially with monopolar derivation, can facilitate detection of CMC and that individual muscle anatomy cannot explain the high interindividual CMC variability.

  20. Phasic stabilization of motor output after auditory and visual distractors.

    PubMed

    Piitulainen, Harri; Bourguignon, Mathieu; Smeds, Eero; De Tiège, Xavier; Jousmäki, Veikko; Hari, Riitta

    2015-12-01

    To maintain steady motor output, distracting sensory stimuli need to be blocked. To study the effects of brief auditory and visual distractors on the human primary motor (M1) cortex, we monitored magnetoencephalographic (MEG) cortical rhythms, electromyogram (EMG) of finger flexors, and corticomuscular coherence (CMC) during right-hand pinch (force 5-7% of maximum) while 1-kHz tones and checkerboard patterns were presented for 100 ms once every 3.5-5 s. Twenty-one subjects (out of twenty-two) showed statistically significant ∼20-Hz CMC. Both distractors elicited a covert startle-like response evident in changes of force and EMG (∼50% of the background variation) but without any visible movement, followed by ∼1-s enhancement of CMC (auditory on average by 75%, P < 0.001; visual by 33%, P < 0.05) and rolandic ∼20-Hz rhythm (auditory by 14%, P < 0.05; visual by 11%, P < 0.01). Directional coupling of coherence from muscle to the M1 cortex (EMG→MEG) increased for ∼0.5 s at the onset of the CMC enhancement, but only after auditory distractor (by 105%; P < 0.05), likely reflecting startle-related proprioceptive afference. The 20-Hz enhancements occurred in the left M1 cortex and were for the auditory stimuli preceded by an early suppression (by 7%, P < 0.05). Task-unrelated distractors modulated corticospinal coupling at ∼20 Hz. We propose that the distractors triggered covert startle-like responses, resulting in proprioceptive afference to the cortex, and that they also transiently disengaged the subject's attention from the fine-motor task. As a result, the corticospinal output was readjusted to keep the contraction force stable.

  1. Response set bias, internal consistency and construct validity of the Oswestry Low Back Pain Disability Questionnaire

    PubMed Central

    Tibbles, Anthony C; Waalen, Judith K; Hains, François C

    1998-01-01

    Background: The Oswestry Low Back Pain Disability Questionnaire (ODQ) is a widely used 10-item paper and pencil measure of disability resulting from low back pain. However, few studies have assessed the psychometric properties of the instrument. This study evaluated the response set bias, the internal consistency, and the construct validity of the ODQ. Objectives: The original ODQ was compared to seven modified versions to examine whether a response set bias existed. The internal consistency of the ODQ was assessed using the Cronbach alpha. Finally, the relationship between scores on the ODQ and the Roland Morris Functional Disability Scal (RM) was examined. Methods: Seven modified versions of the ODQ were developed from the original. One of the eight versions was randomly allocated to 102 adult patients presenting with low lack pain. There was no attempt to select patients on the basis of pain intensity or prior treatment so as to maximize the range and diversity of low back pain sufferers. Results: Results suggest that the responses given on the eight versions of the ODQ are a function of content and not of the format in which the items are presented. The ODQ also has strong internal consisstency (alpha = 0.85) and is strongly correlated to the RM (r = .70, p = .0005). The ODQ is a significant predictor of the RM scores (T-9.45, p = .0005) and duration of symptoms (T = -2.17, p = .0325). Conclusion: The ODQ appears to possess stable psychometric properties. The use of more than one version provides practitioners with a means of repeatedly assessing the disability levels of patients suffering from low back pain over the course of treatment.

  2. Impact of physical and psychosocial factors on disability caused by lumbar pain amongst fishing sector workers.

    PubMed

    Rodríguez-Romero, Beatriz; Pita-Fernández, Salvador; Carballo-Costa, Lidia

    2013-07-01

    Functional disability due to lumbar pain should be considered from the biopsychosocial model. There is inconclusive evidence as to whether the key determining factors in this form of disability are psychosocial or physical. Our aim is to identify variables that cause functional disability due to lumbar pain amongst shellfish gatherers in Galicia by means of a cross-sectional survey. Participants (N = 929) completed a self-administered, paper-based questionnaire including sociodemographic and lifestyle issues, as well as the nature of the lumbar pain, the presence of musculoskeletal pain in other regions of the body, the Roland-Morris Disability Questionnaire (RMDQ) and SF-36. Univariate examination, ROC curve and logistic regression analyses were performed. Most of these workers are women (98.7 %), with a mean age of 50.6 years. The point-prevalence of lumbar pain stands at 65.5 %. The RMDQ mean was 4.9 (SD = 4.7). In the logistic regression analysis, the variables associated with disability (RMDQ > median) were age (OR = 1.04), physical exercise (OR = 0.57), pain intensity (OR = 1.16), the number of regions of musculoskeletal pain (OR = 1.24) and mental health (SF-36) (OR = -0.95). Functional disability is determined by the physical nature of the pain and mental health attributes, although the former has a greater impact. In decreasing order of importance, functional disability is attributable to the presence of lower back pain, the number of regions of musculoskeletal pain, the intensity of that pain and age. Regular physical exercise and better mental health have a protective effect on disability.

  3. Comparison of efficacy of neural therapy and physical therapy in chronic low back pain.

    PubMed

    Atalay, Nilgun Simsir; Sahin, Fusun; Atalay, Ali; Akkaya, Nuray

    2013-01-01

    The aim of this prospective study was to evaluate the effects of neural therapy, and physical therapy on level of pain, disability, quality of life, and psychological status in patients with chronic low back pain. Patients admitted to the physical therapy and rehabilitation outpatient clinic with the complaint of low back pain of at least 3 months duration. Group 1 (n=27), physical therapy (PT, hotpack, ultrasound, TENS 15 sessions), group 2 (n=33), neural therapy (NT, 1:1 mixture of 20 mg/mL Lidocaine HCl (Jetokain simplex®) and saline for 5 sessions. For pain, Visual Analogue Scale (VAS), for disability Roland Morris Disability Questionnaire (RMDQ), for quality-of-life Nottingham-Health-Profile (NHP), for depression, and anxiety, Hospital Anxiety-Depression Scale (HADS) were used before and after the treatment. Mean age was 47.3±11.32 years, symptom time was 13.78±11.98 months. There were no differences for demographic variables between groups. Significant improvements were detected for VAS, RMDQ, NHP-Pain, NHP-Physical activity, HADS for both of two groups after treatment. In addition to these findings, significant improvements were found for NHP-Energy, NHP-Social isolation in NT group. The differences of pre- and post-treatment values of parameters were evaluated for each group. Although there were no differences for VAS, NHP-sleep, NHP-Emotional reaction, HADS between groups, RMDQ, NHP-Pain, NHP-Physical activity, NHP-Social isolation were higher in NT than PT before treatment, the improvements for these parameters were better in NT than PT. In conclusion both of NT and PT are effective on pain, function, quality of life, anxiety, and depression in patients with chronic low back pain.

  4. Chronic pain coping styles in patients with herniated lumbar discs and coexisting spondylotic changes treated surgically: Considering clinical pain characteristics, degenerative changes, disability, mood disturbances, and beliefs about pain control

    PubMed Central

    Misterska, Ewa; Jankowski, Roman; Głowacki, Maciej

    2013-01-01

    Background Pain catastrophizing, appraisals of pain control, styles of coping, and social support have been suggested to affect functioning in patients with low back pain. We investigated the relation of chronic pain coping strategies to psychological variables and clinical data, in patients treated surgically due to lumbar disc herniation and coexisting spondylotic changes. Material/Methods The average age of study participants (n=90) was 43.47 years (SD 10.21). Patients completed the Polish versions of the Chronic Pain Coping Inventory-42 (PL-CPCI-42), Beck Depression Inventory (BDI-PL), Coping Strategies Questionnaire (CSQ-PL), Beliefs about Pain Control Questionnaire (BPCQ-PL), and Roland-Morris Disability Questionnaire (RMQ-PL). Results In the PL-CPCI-42 results, resting, guarding and coping self-statements were frequently used as coping strategies (3.96 SD 1.97; 3.72 SD 1.72; 3.47 SD 2.02, respectively). In the CSQ-PL domains, catastrophizing and praying/hoping were frequently used as coping strategies (3.62 SD 1.19). The mean score obtained from the BDI-PL was 11.86 SD 7.23, and 12.70 SD 5.49 from the RMDQ-PL. BPCQ-PL results indicate that the highest score was in the subscale measuring beliefs that powerful others can control pain (4.36 SD 0.97). Exercise correlated significantly with beliefs about internal control of pain (rs=0.22). We identified associations between radiating pain and guarding (p=0.038) and between sports recreation and guarding (p=0.013) and task persistence (p=0.041). Conclusions Back pain characteristics, depressive mood, disability, and beliefs about personal control of pain are related to chronic LBP coping styles. Most of the variables related to advancement of degenerative changes were not associated with coping efforts. PMID:24370564

  5. CO2 Trapping in Reservoirs with Fluvial Architecture: Sensitivity to Heterogeneity and Hysteresis in Characteristic Relationships for Different Rock Types

    NASA Astrophysics Data System (ADS)

    Gershenzon, N. I.; Ritzi, R. W., Jr.; Dominic, D. F.; Mehnert, E.; Okwen, R. T.

    2015-12-01

    Naum I. Gershenzona, Robert W. Ritzi Jr.a, David F. Dominica, Edward Mehnertb, and Roland T. OkwenbaDepartment of Earth and Environmental Sciences, Wright State University, 3640 Col. Glenn Hwy., Dayton, OH 45435, USAbIllinois State Geological Survey, Prairie Research Institute, University of Illinois at Urbana-Champaign, 615 East Peabody Drive, Champaign, IL 61820, USA A number of important candidate CO2 reservoirs exhibit sedimentary architecture reflecting fluvial deposition. Recent studies have led to new conceptual and quantitative models for sedimentary architecture in fluvial deposits over a range of scales that are relevant to CO2 injection and storage, led to new geocellular modelling approaches for representing this architecture, and led to new computational studies of CO2 plume dynamics during and after injection. The processes of CO2 trapping depend upon a complex system of non-linear and hysteretic characteristic relationships including how relative permeability and capillary pressure vary with brine and CO2 saturation. New computational studies of capillary trapping in conglomeratic reservoirs strongly suggest that representing small-scale (decimeter to meter) textural facies among different rock types, including their organization within a hierarchy of larger-scale stratification, representing differences in characteristic relationships between rock types, and representing hysteresis in characteristic curves can all be critical to understanding trapping processes. In this context, CO2trapping was evaluated in conglomeratic reservoirs with fluvial architecture including different rock types with different and hysteretic characteristic curves and with capillary pressure defined for each rock type using two different conventional approaches, i.e. Brooks-Corey and van Genuchten. The results show that in these reservoirs the capillary trapping rates are quite sensitive to differences between the Brooks-Corey and van Genuchten approaches, and that

  6. The effects of risk factors on EEG and seizure in children with ADHD.

    PubMed

    Kartal, Ayşe; Aksoy, Erhan; Deda, Gülhis

    2017-03-01

    Attention-deficit hyperactivity disorder (ADHD) is one of the most commonly seen developmental disorders in childhood. Its etiology, however, is not well known even though bio-psycho-social reasons have been thought to play a big role. The aims of this retrospective study are to identify the risk factors of ADHD in patients diagnosed with ADHD in childhood, analyze the relationship between clinical symptoms and risk factors to which they were exposed and determine their effects on prospective electrophysiological findings. Longitudinal cohort study of all children with ADHD treated at Ankara University Medical University during 2007-2012, with follow-up to ascertain risk factors and seizure and EEG abnormalities outcome. Multinominal univariate logistic regression analysis was used to calculate adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for associations. Epileptiform discharges were found in 32 (22.9%) of the 140 ADHD patients. Of these, 71.9% had focal epileptiform discharges and 28.1% had generalized epileptiform discharges. The focal epileptiform discharges were most prevalent from the rolandic area. Among the 140 patients, 20 (14.3%) had a previous history of seizure, and all twenty had epileptiform discharges on EEG whereas none of the patients who had normal EEG had a seizure history. The rates of epileptiform discharges were significantly related to gestational age and asphyxia (RR: 1.8, 95% CI 0.3, 9.3; RR: 9.6, 95% CI 2.3, 40, respectively), whereas the rates of epilepsy were related to asphyxia but not gestational age. History of asphyxia and prematurity do seem to increase the risk of EEG abnormality in patients with ADHD. Modification of these environmental risk factors by evidence-based prevention programs may help to decrease the burden of ADHD.

  7. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children

    PubMed Central

    Liu, Meng-Jia; Su, Xiao-jun; MD, Xiu-Yu Shi; Wu, Ge-fei; Zhang, Yu-qin; Gao, Li; Wang, Wei; Liao, Jian-xiang; Wang, Hua; Mai, Jian-ning; Gao, Jing-yun; Shu, Xiao-mei; Huang, Shao-ping; Zhang, Li; Zou, Li-Ping

    2017-01-01

    Abstract This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred. Twenty-five medical centers participate in this clinical trial. The general information, clinical information, and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups was compared, and usefulness of the most commonly used AEDs was evaluated. A total of 1817 subjects were collected. The average age of the subject was 8.81 years. The average age of onset is 6.85 years (1–14 years). Male-to-female ratio is 1.13:1. A total of 62.9% of the patients are receiving monotherapies, and 10.6% are receiving multidrug therapy. Both age and course of disease of treated rolandic epilepsy (RE) patients are significantly different from those of untreated patients. Bilateral findings on electroencephalography (EEG) are less seen in patients with monotherapy compared with patients with multidrug therapy. Except for 25.4% patients not taking any AEDs, oxcarbazepine (OXC), sodium valproate (VPA), and levetiracetam (LEV) are the most commonly used 3 AEDs. VPA and LEV are commonly used in add-on therapy. OXC and LEV are more effective as monotherapy than VPA. Age of onset of Chinese RE patients is 6.85 years. Bilateral findings on EEG could be a risk factor to require multidrug therapy. In Chinese patients, OXC, VPA, and LEV are most commonly used AEDs as monotherapy and OXC and LEV are more effective than VPA. PMID:28121917

  8. Neuropathic Pain in Elderly Patients with Chronic Low Back Painand Effects of Pregabalin: A Preliminary Study

    PubMed Central

    Ito, Kenyu; Hida, Tetsuro; Ito, Sadayuki; Harada, Atsushi

    2015-01-01

    Study Design Preliminary study. Purpose To assess the association of neuropathic pain with chronic low back pain (LBP) and the effect of pregabalin on neuropathic pain in the elderly. Overview of Literature Of those with chronic LBP, 37% were predominantly presenting with neuropathic pain in young adults. Pregabalin is effective for pain in patients with diabetic neuropathy and peripheral neuralgia. No study has reported on the effects of pregabalin for chronic LBP in elderly patients yet. Methods Pregabalin was administered to 32 patients (age, ≥65 years) with chronic LBP for 4 weeks. Pain and activities of daily living were assessed using the Neuropathic Pain Screening Questionnaire (NePSQ), the pain DETECT questionnaire, visual analog scale, the Japanese Orthopedic Association score, the short form of the McGill Pain Questionnaire and the Roland Morris Disability Questionnaire. Modic change and spinal canal stenosis were investigated using magnetic resonance imaging. Results Altogether, 43.3% of patients had neuropathic pain according to the NePSQ and 15.6% patients had pain according to the pain DETECT. The efficacy rate of pregabalin was 73.3%. A significant effect was observed in patients with neuropathic pain after 4 weeks of administration. Conclusions Neuropathic pain was slightly less frequently associated with chronic LBP in the elderly. Pregabalin was effective in reducing pain in patients with chronic LBP accompanied with neuropathic pain. Lumbar spinal stenosis and lower limb symptoms were observed in patients with neuropathic pain. We recommend the use of pregabalin for patients after evaluating a screening score, clinical symptoms and magnetic resonance imaging studies. PMID:25901238

  9. Validation of the Brazilian-Portuguese Version of the Gesture Behavior Test for Patients with Non-Specific Chronic Low Back Pain

    PubMed Central

    Furtado, Ricardo; Jones, Anamaria; Furtado, Rita NV; Jennings, Fábio; Natour, Jamil

    2009-01-01

    OBJECTIVE: To develop a Brazilian version of the gesture behavior test (GBT) for patients with chronic low back pain. METHODS: Translation of GBT into Portuguese was performed by a rheumatologist fluent in the language of origin (French) and skilled in the validation of questionnaires. This translated version was back-translated into French by a native-speaking teacher of the language. The two translators then created a final consensual version in Portuguese. Cultural adaptation was carried out by two rheumatologists, one educated patient and the native-speaking French teacher. Thirty patients with chronic low back pain and fifteen healthcare professionals involved in the education of patients with low back pain through back schools (gold-standard) were evaluated. Reproducibility was initially tested by two observers (inter-observer); the procedures were also videotaped for later evaluation by one of the observers (intra-observer). For construct validation, we compared patients’ scores against the scores of the healthcare professionals. RESULTS: Modifications were made to the GBT for cultural reasons. The Spearman’s correlation coefficient and the intra-class coefficient, which was employed to measure reproducibility, ranged between 0.87 and 0.99 and 0.94 to 0.99, respectively (p < 0.01). With regard to validation, the Mann-Whitney test revealed a significant difference (p < 0.01) between the averages for healthcare professionals (26.60; SD 2.79) and patients (16.30; SD 6.39). There was a positive correlation between the GBT score and the score on the Roland Morris Disability Questionnaire (r= 0.47). CONCLUSIONS: The Brazilian version of the GBT proved to be a reproducible and valid instrument. In addition, according to the questionnaire results, more disabled patients exhibited more protective gesture behavior related to low-back. PMID:19219312

  10. Shared and distinct anatomical correlates of semantic and phonemic fluency revealed by lesion-symptom mapping in patients with ischemic stroke.

    PubMed

    Biesbroek, J Matthijs; van Zandvoort, Martine J E; Kappelle, L Jaap; Velthuis, Birgitta K; Biessels, Geert Jan; Postma, Albert

    2016-05-01

    Semantic and phonemic fluency tasks are frequently used to test executive functioning, speed and attention, and access to the mental lexicon. In semantic fluency tasks, subjects are required to generate words belonging to a category (e.g., animals) within a limited time window, whereas in phonemic fluency tasks subjects have to generate words starting with a given letter. Anatomical correlates of semantic and phonemic fluency are currently assumed to overlap in left frontal structures, reflecting shared executive processes, and to be distinct in left temporal and right frontal structures, reflecting involvement of distinct memory processes and search strategies. Definite evidence for this assumption is lacking. To further establish the anatomical correlates of semantic and phonemic fluency, we applied assumption-free voxel-based and region-of-interest-based lesion-symptom mapping in 93 patients with ischemic stroke. Fluency was assessed by asking patients to name animals (semantic), and words starting with the letter N and A (phonemic). Our findings indicate that anatomical correlates of semantic and phonemic fluency overlap in the left inferior frontal gyrus and insula, reflecting shared underlying cognitive processes. Phonemic fluency additionally draws on the left rolandic operculum, which might reflect a search through phonological memory, and the middle frontal gyrus. Semantic fluency additionally draws on left medial temporal regions, probably reflecting a search through semantic memory, and the right inferior frontal gyrus, which might reflect the application of a visuospatial mental imagery strategy in semantic fluency. These findings establish shared and distinct anatomical correlates of semantic and phonemic fluency.

  11. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): first annual report.

    PubMed

    de By, Theo M M H; Mohacsi, Paul; Gummert, Jan; Bushnaq, Hasan; Krabatsch, Thomas; Gustafsson, Finn; Leprince, Pascal; Martinelli, Luigi; Meyns, Bart; Morshuis, Michiel; Netuka, Ivan; Potapov, Evgenij; Zittermann, Armin; Delmo Walter, Eva Maria; Hetzer, Roland

    2015-05-01

    The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) was founded on 10 December 2009 with the initiative of Roland Hetzer (Deutsches Herzzentrum Berlin, Berlin, Germany) and Jan Gummert (Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany) with 15 other founding international members. It aims to promote scientific research to improve care of end-stage heart failure patients with ventricular assist device or a total artificial heart as long-term mechanical circulatory support. Likewise, the organization aims to provide and maintain a registry of device implantation data and long-term follow-up of patients with mechanical circulatory support. Hence, EUROMACS affiliated itself with Dendrite Clinical Systems Ltd to offer its members a software tool that allows input and analysis of patient clinical data on a daily basis. EUROMACS facilitates further scientific studies by offering research groups access to any available data wherein patients and centres are anonymized. Furthermore, EUROMACS aims to stimulate cooperation with clinical and research institutions and with peer associations involved to further its aims. EUROMACS is the only European-based Registry for Patients with Mechanical Circulatory Support with rapid increase in institutional and individual membership. Because of the expeditious data input, the European Association for Cardiothoracic Surgeons saw the need to optimize the data availability and the significance of the registry to improve care of patients with mechanical circulatory support and its potential contribution to scientific intents; hence, the beginning of their alliance in 2012. This first annual report is designed to provide an overview of EUROMACS' structure, its activities, a first data collection and an insight to its scientific contributions.

  12. Intermolecular forces and the glass transition.

    PubMed

    Hall, Randall W; Wolynes, Peter G

    2008-01-17

    Random first-order transition theory is used to determine the role of attractive and repulsive interactions in the dynamics of supercooled liquids. Self-consistent phonon theory, an approximate mean field treatment consistent with random first-order transition theory, is used to treat individual glassy configurations, whereas the liquid phase is treated using common liquid-state approximations. Free energies are calculated using liquid-state perturbation theory. The transition temperature, T*A, the temperature where the onset of activated behavior is predicted by mean field theory; the lower crossover temperature, T*C, where barrierless motions actually occur through fractal or stringy motions (corresponding to the phenomenological mode coupling transition temperature); and T*K, the Kauzmann temperature (corresponding to an extrapolated entropy crisis), are calculated in addition to T*g, the glass transition temperature that corresponds to laboratory cooling rates. Relationships between these quantities agree well with existing experimental and simulation data on van der Waals liquids. Both the isobaric and isochoric behavior in the supercooled regime are studied, providing results for DeltaCV and DeltaCp that can be used to calculate the fragility as a function of density and pressure, respectively. The predicted variations in the alpha-relaxation time with temperature and density conform to the empirical density-temperature scaling relations found by Casalini and Roland. We thereby demonstrate the microscopic origin of their observations. Finally, the relationship first suggested by Sastry between the spinodal temperature and the Kauzmann temperatures, as a function of density, is examined. The present microscopic calculations support the existence of an intersection of these two temperatures at sufficiently low temperatures.

  13. The Influence of verbalization on the pattern of cortical activation during mental arithmetic

    PubMed Central

    2012-01-01

    Background The aim of the present functional magnetic resonance imaging (fMRI) study at 3 T was to investigate the influence of the verbal-visual cognitive style on cerebral activation patterns during mental arithmetic. In the domain of arithmetic, a visual style might for example mean to visualize numbers and (intermediate) results, and a verbal style might mean, that numbers and (intermediate) results are verbally repeated. In this study, we investigated, first, whether verbalizers show activations in areas for language processing, and whether visualizers show activations in areas for visual processing during mental arithmetic. Some researchers have proposed that the left and right intraparietal sulcus (IPS), and the left angular gyrus (AG), two areas involved in number processing, show some domain or modality specificity. That is, verbal for the left AG, and visual for the left and right IPS. We investigated, second, whether the activation in these areas implied in number processing depended on an individual's cognitive style. Methods 42 young healthy adults participated in the fMRI study. The study comprised two functional sessions. In the first session, subtraction and multiplication problems were presented in an event-related design, and in the second functional session, multiplications were presented in two formats, as Arabic numerals and as written number words, in an event-related design. The individual's habitual use of visualization and verbalization during mental arithmetic was assessed by a short self-report assessment. Results We observed in both functional sessions that the use of verbalization predicts activation in brain areas associated with language (supramarginal gyrus) and auditory processing (Heschl's gyrus, Rolandic operculum). However, we found no modulation of activation in the left AG as a function of verbalization. Conclusions Our results confirm that strong verbalizers use mental speech as a form of mental imagination more strongly than

  14. Functional MRI and intraoperative brain mapping to evaluate brain plasticity in patients with brain tumours and hemiparesis

    PubMed Central

    Roux, F; Boulanouar, K; Ibarrola, D; Tremoulet, M; Chollet, F; Berry, I

    2000-01-01

    OBJECTIVE—To support the hypothesis about the potential compensatory role of ipsilateral corticofugal pathways when the contralateral pathways are impaired by brain tumours.
METHODS—Retrospective analysis was carried out on the results of functional MRI (fMRI) of a selected group of five paretic patients with Rolandic brain tumours who exhibited an abnormally high ipsilateral/contralateral ratio of activation—that is, movements of the paretic hand activated predominately the ipsilateral cortex. Brain activation was achieved with a flexion extension of the fingers. Statistical parametric activation was obtained using a t test and a threshold of p<0.001. These patients, candidates for tumour resection, also underwent cortical intraoperative stimulation that was correlated to the fMRI spatial data using three dimensional reconstructions of the brain. Three patients also had postoperative control fMRI.
RESULTS—The absence of fMRI activation of the primary sensorimotor cortex normally innervating the paretic hand for the threshold chosen, was correlated with completely negative cortical responses of the cortical hand area during the operation. The preoperative fMRI activation of these patients predominantly found in the ipsilateral frontal and primary sensorimotor cortices could be related to the residual ipsilateral hand function. Postoperatively, the fMRI activation returned to more classic patterns of activation, reflecting the consequences of therapy.
CONCLUSION—In paretic patients with brain tumours, ipsilateral control could be implicated in the residual hand function, when the normal primary pathways are impaired. The possibility that functional tissue still remains in the peritumorous sensorimotor cortex even when the preoperative fMRI and the cortical intraoperative stimulations are negative, should be taken into account when planning the tumour resection and during the operation.

 PMID:10990503

  15. Group-level spatial independent component analysis of Fourier envelopes of resting-state MEG data.

    PubMed

    Ramkumar, Pavan; Parkkonen, Lauri; Hyvärinen, Aapo

    2014-02-01

    We developed a data-driven method to spatiotemporally and spectrally characterize the dynamics of brain oscillations in resting-state magnetoencephalography (MEG) data. The method, called envelope spatial Fourier independent component analysis (eSFICA), maximizes the spatial and spectral sparseness of Fourier energies of a cortically constrained source current estimate. We compared this method using a simulated data set against 5 other variants of independent component analysis and found that eSFICA performed on par with its temporal variant, eTFICA, and better than other ICA variants, in characterizing dynamics at time scales of the order of minutes. We then applied eSFICA to real MEG data obtained from 9 subjects during rest. The method identified several networks showing within- and cross-frequency inter-areal functional connectivity profiles which resemble previously reported resting-state networks, such as the bilateral sensorimotor network at ~20Hz, the lateral and medial parieto-occipital sources at ~10Hz, a subset of the default-mode network at ~8 and ~15Hz, and lateralized temporal lobe sources at ~8Hz. Finally, we interpreted the estimated networks as spatiospectral filters and applied the filters to obtain the dynamics during a natural stimulus sequence presented to the same 9 subjects. We observed occipital alpha modulation to visual stimuli, bilateral rolandic mu modulation to tactile stimuli and video clips of hands, and the temporal lobe network modulation to speech stimuli, but no modulation of the sources in the default-mode network. We conclude that (1) the proposed method robustly detects inter-areal cross-frequency networks at long time scales, (2) the functional relevance of the resting-state networks can be probed by applying the obtained spatiospectral filters to data from measurements with controlled external stimulation.

  16. How social myths about childhood, motherhood and medicine affect the detection of subtle developmental problems in young children.

    PubMed

    Williams, Jane

    Focus by child health professionals on the well-being of young Australian children and their families has intensified in the past decade, with particular attention drawn to the importance of the early detection and intervention of developmental problems. While many children with developmental difficulties are detected in the preschool years, those with more subtle forms of developmental problems are often only noticed by their mothers, passing unnoticed by professionals until the children begin school and fail socially or academically. This study aimed to ascertain ways in which child health professionals may utilise the experience of mothers to improve early recognition and diagnosis of subtle developmental and behavioural problems in children. French philosopher, Roland Barthes (1973) proposed that myths play an important social role in defining underlying social values that affect how people interpret what others say or do. This paper explores how the social myths of childhood, motherhood and medicine impact upon the early detection of children with subtle developmental problems. In particular, it examines how social myths affect when and how mothers become concerned about their children's development, from whom they seek advice, and the responses which mothers receive in regard to their concerns. Mythical notions of the 'blameless child', 'boys will be boys' and 'children who look OK are OK', and the constituted myth of motherhood, are all shown to affect when mothers become concerned about their children's development. What mothers do about their concerns and the responses they receive from child health professionals are also influenced by these myths. The myth of medicine is also examined to determine how it affects communication between mothers and doctors, the roles and responsibilities of doctors, and the value placed on a mother's concerns by doctors.

  17. Short-Term Effects of Kinesio Taping in Women with Pregnancy-Related Low Back Pain: A Randomized Controlled Clinical Trial.

    PubMed

    Kaplan, Şeyhmus; Alpayci, Mahmut; Karaman, Erbil; Çetin, Orkun; Özkan, Yasemin; İlter, Server; Şah, Volkan; Şahin, Hanım Güler

    2016-04-18

    BACKGROUND Pregnancy-related low back pain is a common condition during pregnancy. Kinesio tape is a drug-free elastic therapeutic tape used for treating various musculoskeletal problems. The aim of this study was to investigate the short-term effects of lumbar Kinesio taping on pain intensity and disability in women with pregnancy-related low back pain. MATERIAL AND METHODS A total of 65 patients with pregnancy-related low back pain were randomly allocated into either Kinesio taping (n=33) or control (n=32) groups. The intervention group was treated with paracetamol plus Kinesio taping, while the control group received only paracetamol. Kinesio taping was applied in the lumbar flexion position, and four I-shaped bands were used. Two bands were attached horizontally, with space correction technique. The remaining 2 bands, 1 on each side of the lumbar spine, were placed vertically, with inhibition technique. Low back pain intensity was measured on a 10-cm visual analogue scale (VAS), and the Roland-Morris Disability Questionnaire (RMDQ) was used for evaluation of disability. RESULTS Pain intensity and RMDQ scores improved significantly in both groups at 5 days compared with baseline. Considering the degree of treatment effect (the change from baseline to day 5), the Kinesio taping group was significantly superior than the control group in all outcome measures (for all, P<0.001). CONCLUSIONS The results of this study indicate that Kinesio taping can be used as a complementary treatment method to achieve effective control of pregnancy-related low back pain.

  18. Sensory-motor networks involved in speech production and motor control: an fMRI study.

    PubMed

    Behroozmand, Roozbeh; Shebek, Rachel; Hansen, Daniel R; Oya, Hiroyuki; Robin, Donald A; Howard, Matthew A; Greenlee, Jeremy D W

    2015-04-01

    Speaking is one of the most complex motor behaviors developed to facilitate human communication. The underlying neural mechanisms of speech involve sensory-motor interactions that incorporate feedback information for online monitoring and control of produced speech sounds. In the present study, we adopted an auditory feedback pitch perturbation paradigm and combined it with functional magnetic resonance imaging (fMRI) recordings in order to identify brain areas involved in speech production and motor control. Subjects underwent fMRI scanning while they produced a steady vowel sound /a/ (speaking) or listened to the playback of their own vowel production (playback). During each condition, the auditory feedback from vowel production was either normal (no perturbation) or perturbed by an upward (+600 cents) pitch-shift stimulus randomly. Analysis of BOLD responses during speaking (with and without shift) vs. rest revealed activation of a complex network including bilateral superior temporal gyrus (STG), Heschl's gyrus, precentral gyrus, supplementary motor area (SMA), Rolandic operculum, postcentral gyrus and right inferior frontal gyrus (IFG). Performance correlation analysis showed that the subjects produced compensatory vocal responses that significantly correlated with BOLD response increases in bilateral STG and left precentral gyrus. However, during playback, the activation network was limited to cortical auditory areas including bilateral STG and Heschl's gyrus. Moreover, the contrast between speaking vs. playback highlighted a distinct functional network that included bilateral precentral gyrus, SMA, IFG, postcentral gyrus and insula. These findings suggest that speech motor control involves feedback error detection in sensory (e.g. auditory) cortices that subsequently activate motor-related areas for the adjustment of speech parameters during speaking.

  19. Descriptive analysis of a 1:1 physiotherapy outpatient intervention post primary lumbar discectomy: one arm of a small-scale parallel randomised controlled trial across two UK sites

    PubMed Central

    Rushton, A; Calcutt, A; Heneghan, N; Heap, A; White, L; Goodwin, P

    2016-01-01

    Objective There is a lack of high-quality evidence for physiotherapy post lumbar discectomy. Substantial heterogeneity in treatment effects may be explained by variation in quality, administration and components of interventions. An optimised physiotherapy intervention may reduce heterogeneity and improve patient benefit. The objective was to describe, analyse and evaluate an optimised 1:1 physiotherapy outpatient intervention for patients following primary lumbar discectomy, to provide preliminary insights. Design A descriptive analysis of the intervention embedded within an external pilot and feasibility trial. Setting Two UK spinal centres. Participants Participants aged ≥18; post primary, single level, lumbar discectomy were recruited. Intervention The intervention encompassed education, advice, mobility and core stability exercises, progressive exercise, and encouragement of early return to work/activity. Patients received ≤8 sessions for ≤8 weeks, starting 4 weeks post surgery (baseline). Outcomes Blinded outcome assessment at baseline and 12 weeks (post intervention) included the Roland Morris Disability Questionnaire. STarT Back data were collected at baseline. Statistical analyses summarised participant characteristics and preplanned descriptive analyses. Thematic analysis grouped related data. Findings Twenty-two of 29 allocated participants received the intervention. STarT Back categorised n=16 (55%) participants ‘not at low risk’. Physiotherapists identified reasons for caution for 8 (36%) participants, commonly risk of overdoing activity (n=4, 18%). There was no relationship between STarT Back and physiotherapists’ evaluation of caution. Physiotherapists identified 154 problems (mean (SD) 5.36 (2.63)). Those ‘not at low risk’, and/or requiring caution presented with more problems, and required more sessions (mean (SD) 3.14 (1.16)). Conclusions Patients present differently and therefore require tailored interventions. These

  20. Eighteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W.

    1993-01-28

    PREFACE The Eighteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 26-28, 1993. There were one hundred and seventeen registered participants which was greater than the attendance last year. Participants were from eight foreign countries: Italy, Japan, United Kingdom, Mexico, New Zealand, the Philippines, Guatemala, and Iceland. Performance of many geothermal fields outside the United States was described in several of the papers. Dean Gary Ernst opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a brief overview of the Department of Energy's current plan. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Mock who also spoke at the banquet. Thirty-nine papers were presented at the Workshop with two papers submitted for publication only. Technical papers were organized in twelve sessions concerning: field operations, The Geysers, geoscience, hot-dry-rock, injection, modeling, slim hole wells, geochemistry, well test and wellbore. Session chairmen were major contributors to the program and we thank: John Counsil, Kathleen Enedy, Harry Olson, Eduardo Iglesias, Marcelo Lippmann, Paul Atkinson, Jim Lovekin, Marshall Reed, Antonio Correa, and David Faulder. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to John Hornbrook who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook

  1. A Randomized, Single-Blind, Placebo-Controlled Study on the Efficacy of the Arthrokinematic Approach-Hakata Method in Patients with Chronic Nonspecific Low Back Pain

    PubMed Central

    Kogure, Akira; Kotani, Kazuhiko; Katada, Shigehiko; Takagi, Hiroshi; Kamikozuru, Masahiro; Isaji, Takashi; Hakata, Setsuo

    2015-01-01

    Study design cized, single-blind, controlled trial. Objective To investigate the efficacy of the Arthrokinematic approach (AKA)-Hakata (H) method for chronic low back pain. Summary of Background Data The AKA-H method is used to manually treat abnormalities of intra-articular movement. Methods One hundred eighty-six patients with chronic nonspecific low back pain randomly received either the AKA-H method (AKA-H group) or the sham technique (S group) monthly for 6 months. Data were collected at baseline and once a month. Outcome measures were pain intensity (visual analogue scale [VAS]) and quality of life (the Roland-Morris Disability Questionnaire [RDQ] and Short Form SF-36 questionnaire [SF-36]). Results At baseline, the VAS, RDQ, and SF-36 scores showed similar levels between the groups. After 6 months, the AKA-H group had more improvement in the VAS (42.8% improvement) and RDQ score (31.1% improvement) than the sham group (VAS: 10.4% improvement; RDQ: 9.8% improvement; both, P < 0.001). The respective scores for the SF-36 subscales (physical functioning, role physical, bodily pain, social functioning, general health perception, role emotional, and mental health) were also significantly more improved in the AKA-H group than in the sham group (all, P < 0.001). The scores for the physical, psychological, and social aspects of the SF-36 subscales showed similar improvement in the AKA-H group. Conclusion The AKA-H method can be effective in managing chronic low back pain. Trial Registration UMIN Clinical Trials Registry (UMIN-CTR) UMIN000006250. PMID:26646534

  2. MEG-based detection and localization of perilesional dysfunction in chronic stroke.

    PubMed

    Chu, Ron K O; Braun, Allen R; Meltzer, Jed A

    2015-01-01

    Post-stroke impairment is associated not only with structural lesions, but also with dysfunction in surviving perilesional tissue. Previous studies using equivalent current dipole source localization of MEG/EEG signals have demonstrated a preponderance of slow-wave activity localized to perilesional areas. Recent studies have also demonstrated the utility of nonlinear analyses such as multiscale entropy (MSE) for quantifying neuronal dysfunction in a wide range of pathologies. The current study utilized beamformer-based reconstruction of signals in source space to compare spectral and nonlinear measures of electrical activity in perilesional and healthy cortices. Data were collected from chronic stroke patients and healthy controls, both young and elderly. We assessed relative power in the delta (1-4 Hz), theta (4-7 Hz), alpha (8-12 Hz) and beta (15-30 Hz) frequency bands, and also measured the nonlinear complexity of electrical activity using MSE. Perilesional tissue exhibited a general slowing of the power spectrum (increased delta/theta, decreased beta) as well as a reduction in MSE. All measures tested were similarly sensitive to changes in the posterior perilesional regions, but anterior perilesional dysfunction was detected better by MSE and beta power. The findings also suggest that MSE is specifically sensitive to electrophysiological dysfunction in perilesional tissue, while spectral measures were additionally affected by an increase in rolandic beta power with advanced age. Furthermore, perilesional electrophysiological abnormalities in the left hemisphere were correlated with the degree of language task-induced activation in the right hemisphere. Finally, we demonstrate that single subject spectral and nonlinear analyses can identify dysfunctional perilesional regions within individual patients that may be ideal targets for interventions with noninvasive brain stimulation.

  3. Theory of classical and quantum transport in monolayers of MoS2

    NASA Astrophysics Data System (ADS)

    Adam, Shaffique

    From the family of new van der Waals materials, the class of layered transition metal dichalcogenides has emerged as a particularly interesting system due to the inherent spin and valley degrees of freedom. In this talk we focus on the interplay between these degrees of freedom and the different types of disorder in monolayers of molybdenum disulphide. Within the semiclassical Drude-Boltzmann formalism, treating the screening of impurities with the random phase approximation, we demonstrate that different scattering mechanisms such as charged impurity scattering, intervalley scattering, and phonons provide different signatures in electronic transport. This allows us to conclude, for example, that in CVD-grown monolayers of MoS2, intervalley scattering dominates over other mechanisms at low temperatures. Interestingly, charged impurities generate spatial inhomogeneity in the carrier density that results in a classical disorder-induced magnetoresistance that can be observed at room temperature. However, at lower temperatures, in this regime of strong intervalley scattering, we predict that the quantum phase-coherent corrections to the conductivity results in a one-parameter crossover from weak localization to weak anti-localization as a function of magnetic field, where this crossover is determined only by the spin lifetime. By comparing with available experimental data, we show that this combined framework allows for a novel way to measure the spin-relaxation in monolayers of MoS2. We find that the spin scattering arises from the Dyakonov-Perel spin-orbit scattering mechanism with a conduction band spin-splitting of about 4 meV, consistent with calculations using density functional theory. Work done in collaboration with Indra Yudhistira and the experimental groups of Goki Eda (NUS), Michael Fuhrer (Monash) and Roland Kawakami (Ohio State), and funded by Singapore National Research Foundation and Ministry of Education.

  4. The Prognosis of Acute Low Back Pain in Primary Care in the U.S. A 2-Year Prospective Cohort Study

    PubMed Central

    Mehling, Wolf E.; Gopisetty, Viranjini; Bartmess-LeVasseur, Elizabeth; Acree, Mike; Pressman, Alice; Goldberg, Harley; Hecht, Frederick M; Carey, Tim; Avins, Andrew L

    2011-01-01

    Study Design Prospective cohort study Objective to assess the prognosis of patients presenting with acute low back pain (LBP) in a primary care setting in the U.S. Summary of Background Data Practice guidelines for acute LBP based on return-to-work outcomes underestimate the development of chronic pain in the primary care setting. Due to differences in inclusion criteria, chronic pain definitions and national health systems, prognostic cohort studies have reported a wide range of results limiting interpretation and generalization. Current data from carefully designed prognostic studies of acute LBP are lacking for the U.S. primary care system. Methods Members of a large health service organization were enrolled after seeking medical care for acute LBP, with or without sciatica, of up to 30 days duration, with no prior episode in the past 12 months and no history of spine surgery. We conducted phone interviews at baseline, six months and two years. Based on receiver operating characteristic analyses, a combination of global perceived recovery with pain intensity was used as primary outcome for chronic pain. Recurrence and multiple secondary outcomes were assessed to allow for comparison with other studies. Results 605 patients had an average pain intensity of 5.6 (numeric rating scale 0–10) and disability of 15.8 (Roland Morris scale 0–24). Eight percent had declared sick leave between pain onset and baseline interview. 13% of 521 patients (86% follow-up) suffered from chronic pain at six months and 19% of 443 patients at 2 years. At six months, 54% had experienced at least one LBP recurrence, and 47% in the subsequent 18 months. Conclusion The prognosis of strictly-defined acute LBP, with or without sciatica, is less favorable than commonly stated in practice guidelines based on failure to return to work. Broad initiatives to develop new means for the primary and secondary prevention of recurrent and chronic LBP are urgently needed. PMID:22504516

  5. A Systematic Review of Outcome Measures Use, Analytical Approaches, Reporting Methods, and Publication Volume by Year in Low Back Pain Trials Published between 1980 and 2012: Respice, adspice, et prospice

    PubMed Central

    Froud, Robert; Patel, Shilpa; Buchbinder, Rachelle; Eldridge, Sandra; Underwood, Martin

    2016-01-01

    Background Increasing patient-reported outcome measures in the 1980s and 1990s led to the development of recommendations at the turn of the millennium for standardising outcome measures in non-specific low back pain (LBP) trials. Whether these recommendations impacted use is unclear. Previous work has examined citation counts, but actual use and change over time, has not been explored. Since 2011, there has been some consensus on the optimal methods for reporting back pain trial outcomes. We explored reporting practice, outcome measure use, and publications over time. Methods We performed a systematic review of LBP trials, searching the European Guidelines for the management of LBP, extending the search to 2012. We abstracted data on publications by year, outcome measure use, analytical approach, and approaches taken to reporting trials outcomes. Data were analysed using descriptive statistics and regression analyses. Results We included 401 trials. The number of published trials per year has increased by a factor of 4.5 from 5.4 (1980–1999) to 24.4 (2000–2012). The most commonly used outcome measures have been the Visual Analogue Scale for pain intensity, which has slowly increased in use since 1980/81 from 20% to 60% of trials by 2012, and the Roland-Morris Disability Questionnaire, which rose to 55% in 2002/2003, and then fell back to 28% by 2012. Most trialists (85%) report between-group mean differences. Few (8%) report individual improvements, and some (4%) report only within-group analyses. Student’s t test, ANOVA, and ANCOVA regression, or mixed models, were the most common approaches to analysis. Conclusions Recommendations for standardising outcomes may have had a limited or inconsistent effect on practice. Since the research community is again considering outcome measures and modifying recommendations, groups offering recommendations should be cognisant that better ways of generating trialist buy-in may be required in order for their

  6. Brain plasticity in Parkinson's disease with freezing of gait induced by action observation training.

    PubMed

    Agosta, Federica; Gatti, Roberto; Sarasso, Elisabetta; Volonté, Maria Antonietta; Canu, Elisa; Meani, Alessandro; Sarro, Lidia; Copetti, Massimiliano; Cattrysse, Erik; Kerckhofs, Eric; Comi, Giancarlo; Falini, Andrea; Filippi, Massimo

    2017-01-01

    Gait disorders represent a therapeutic challenge in Parkinson's disease (PD). This study investigated the efficacy of 4-week action observation training (AOT) on disease severity, freezing of gait and motor abilities in PD, and evaluated treatment-related brain functional changes. 25 PD patients with freezing of gait were randomized into two groups: AOT (action observation combined with practicing the observed actions) and "Landscape" (same physical training combined with landscape-videos observation). At baseline and 4-week, patients underwent clinical evaluation and fMRI. Clinical assessment was repeated at 8-week. At 4-week, both groups showed reduced freezing of gait severity, improved walking speed and quality of life. Moreover, AOT was associated with reduced motor disability and improved balance. AOT group showed a sustained positive effect on motor disability, walking speed, balance and quality of life at 8-week, with a trend toward a persisting reduced freezing of gait severity. At 4-week vs. baseline, AOT group showed increased recruitment of fronto-parietal areas during fMRI tasks, while the Landscape group showed a reduced fMRI activity of the left postcentral and inferior parietal gyri and right rolandic operculum and supramarginal gyrus. In AOT group, functional brain changes were associated with clinical improvements at 4-week and predicted clinical evolution at 8-week. AOT has a more lasting effect in improving motor function, gait and quality of life in PD patients relative to physical therapy alone. AOT-related performance gains are associated with an increased recruitment of motor regions and fronto-parietal mirror neuron and attentional control areas.

  7. Plasma-Photocatalyst Interaction for VOC Removal: Origin of the Synergy

    NASA Astrophysics Data System (ADS)

    Rousseau, Antoine

    2007-10-01

    It is well known that the coupling of an atmospheric non-thermal plasma with catalytic materials lead to synergetic effects for the abatement of some volatiles organic compounds (VOC). We analyze, here, the mechanisms of such a synergy where the catalyst is a porous semi-conductor (TiO2). Different porous materials are compared: silica fibers possibly containing SiO2 and/or TiO2 nanoparticles. The respective influence of the porosity versus the chemical type of the catalyst is investigated and the oxidizing species are identified using two complementary approaches. 1) Efficiency of the plasma-catalyst coupling in a dielectric barrier discharge (DBD) at atmospheric pressure, 2) Plasma-catalytic surface interaction in a pulsed low pressure discharge. It is shown that the VOC oxidation scales as a function of the specific injected energy and occurs mainly on the porous surface due to short-life species produced the plasma [1-3]; Time resolved and in-situ measurements using laser absorption spectroscopy and emission spectroscopy in a low-pressure experiment have shown that i) plasma-TiO2 synergy is also evidenced at low pressure[4], ii) O atoms are reversively adsorbed on porous nanoparticles of TiO2; their desorption occur during the first millisecond of a plasma pulse [5], iii) air-plasma pre-treatment of the porous material leads to an enhancement of VOC adsorption on porous TiO2 and has no influence on porous silica. [1] U. Roland et al. Catalysis Today 73 315--323 [2] F. Thevenet et al. Catal. Today 122 (2007) 186--194 [3] F. Thevenet et al. International Journal of Plasma Environmental Science and Technology, 1, (2007), 52-56 [4] A. Rousseau et al. Appl. Phys. Let. 87, 221501 (2005) [5] Allegraud et al. J. Phys. D. : Appl. Phys submitted.

  8. Short-Term Effects of Kinesio Taping in Women with Pregnancy-Related Low Back Pain: A Randomized Controlled Clinical Trial

    PubMed Central

    Kaplan, Şeyhmus; Alpayci, Mahmut; Karaman, Erbil; Çetin, Orkun; Özkan, Yasemin; İlter, Server; Şah, Volkan; Şahin, Hanım Güler

    2016-01-01

    Background Pregnancy-related low back pain is a common condition during pregnancy. Kinesio tape is a drug-free elastic therapeutic tape used for treating various musculoskeletal problems. The aim of this study was to investigate the short-term effects of lumbar Kinesio taping on pain intensity and disability in women with pregnancy-related low back pain. Material/Methods A total of 65 patients with pregnancy-related low back pain were randomly allocated into either Kinesio taping (n=33) or control (n=32) groups. The intervention group was treated with paracetamol plus Kinesio taping, while the control group received only paracetamol. Kinesio taping was applied in the lumbar flexion position, and four I-shaped bands were used. Two bands were attached horizontally, with space correction technique. The remaining 2 bands, 1 on each side of the lumbar spine, were placed vertically, with inhibition technique. Low back pain intensity was measured on a 10-cm visual analogue scale (VAS), and the Roland-Morris Disability Questionnaire (RMDQ) was used for evaluation of disability. Results Pain intensity and RMDQ scores improved significantly in both groups at 5 days compared with baseline. Considering the degree of treatment effect (the change from baseline to day 5), the Kinesio taping group was significantly superior than the control group in all outcome measures (for all, P<0.001). Conclusions The results of this study indicate that Kinesio taping can be used as a complementary treatment method to achieve effective control of pregnancy-related low back pain. PMID:27088271

  9. Are tactile acuity and clinical symptoms related to differences in perceived body image in patients with chronic nonspecific lower back pain?

    PubMed

    Nishigami, Tomohiko; Mibu, Akira; Osumi, Michihiro; Son, Kouki; Yamamoto, Shyogo; Kajiwara, Saori; Tanaka, Katsuyoshi; Matsuya, Ayako; Tanabe, Akihito

    2015-02-01

    Clinically, perceived image of the lower back and the two-point discrimination (TPD) test are used as markers for evaluating alterations of cortical reorganization. The purpose of the present study was to examine whether TPD and selected clinical findings are different in subgroups of individuals with chronic nonspecific lower back pain (CNLBP) based on body image drawings. Forty-two patients with CNLBP and seventeen healthy individuals were recruited. Perceived body image, TPD and clinical profiles was measured. Of the patients with CNLBP, 42.8% had a normal perceived body image, 28.5% an expanded image, and 28.5% a shrunken image. The TPD distance threshold was significantly larger for the expanded subgroup (13.3 ± 6.8 mm) compared with the control (5.5 ± 3.8 mm; Difference, 7.8; 95%CI, 1.83 to 13.66; p < 0.05) and normal subgroups (4.5 ± 5.5 mm; Difference, 8.8; 95%CI, 2.90 to 14.59; p < 0.05). No significant differences in pain intensity, duration of pain, Roland Morris Disability Questionnaire (RDQ), and Pain Catastrophizing Scale (PCS) scores were found between three body image subgroups. Our results suggest that TPD is increased in patients who report an expanded perceived image of the lower back compared with healthy individuals and patients who report a normal image. The effectiveness of new rehabilitation techniques may be evaluated by assessing perceived image of the lower back and TPD values for patients with CNLBP before and after treatment.

  10. Role of Epidural Injections to Prevent Surgical Intervention in Patients with Chronic Sciatica: A Systematic Review and Meta-Analysis

    PubMed Central

    Kim, Sunny

    2016-01-01

    Objective: The aim of this study is to evaluate the efficacy of the different types of epidural injections (EI) to prevent surgical intervention in patients suffering from chronic sciatica due to lumbar disc herniation (LDH). Material and Methods: Studies were identified by searching PubMed, MEDLINE, and Google Scholar to retrieve all available relevant articles. Lists of references of several systematic reviews were also used for scanning further references. Publications from the past ten years (2006-2016) were considered, and all studies selected were in the English language only. The studies employed specified the use of EI to treat sciatica caused by LDH. A total of 19 papers meeting the eligibility criteria (mentioned below) were included in this study. The pain scores, functional disability scores, and surgical rates from these studies were considered, and meta-analysis was performed. Outcome measures: Pain scores, functional disability scores, and surgical rates were assessed from the included studies. The Numeric Rating Scale (NRS) and Visual Analogue Scale (VAS) have been the most commonly used baseline scales for pain evaluation followed by the Verbal Numerical Rating Scale (VNRS) and Japanese Orthopedic Association (JOA). The Oswestry Disability Index (ODI) and Roland Morris Disability Questionnaire (RMDQ) scales were used for the functional disability scoring system in the literature. Results: Significant improvement in the pain scores and functional disability scores were observed. Additionally, greater than 80% of the patients suffering from chronic sciatica caused by LDH could successfully prevent surgical intervention after EI treatment with or without steroids. Conclusion: The management of sciatica with EI treatment results in significant improvements in the pain score, functional disability score, and surgical rate. We concluded that EI provides new hope to prevent surgical intervention in patients suffering from sciatica caused by LDH. PMID

  11. A Randomized Trial Comparing Yoga, Stretching, and a Self-care Book for Chronic Low Back Pain

    PubMed Central

    Sherman, Karen J.; Cherkin, Daniel C.; Wellman, Robert D.; Cook, Andrea J.; Hawkes, Rene J.; Delaney, Kristin; Deyo, Richard A.

    2012-01-01

    Background Chronic low back pain is a common problem lacking highly effective treatment options. Small trials suggest that yoga may have benefits for this condition. This trial was designed to determine whether yoga is more effective than conventional stretching exercises or a self-care book for primary care patients with chronic low back pain. Methods 228 adults with chronic low back pain were randomized to 12 weekly classes of yoga (n=92) or conventional stretching exercises (n=91) or a self-care book (n=45). Back-related functional status (modified Roland Disability Questionnaire, 23-point scale) and bothersomeness of pain (11-point numerical scale) at 12 weeks were the primary outcomes. Outcomes were assessed at baseline, 6, 12 and 26 weeks by interviewers unaware of treatment group. Results After adjustment for baseline values, 12-week outcomes for the yoga group were superior to those for the self-care group (mean difference for function = −2.5 [95% CI= −3.7 to −1.3; P<0.001]; mean difference for symptoms = −1.1 [95% CI= −1.7 to −0.4; P<0.001]). At 26 weeks, function for the yoga group remained superior (mean difference = −1.8 [95% CI= − 3.1 to −0.5; P<0.0001]). Yoga was not superior to conventional stretching exercises at any time point. Conclusions Yoga classes were more effective than a self-care book, but not stretching classes, in improving function and reducing symptoms due to chronic low back pain, with benefits lasting at least several months. PMID:22025101

  12. Applications of finite element simulation in orthopedic and trauma surgery

    PubMed Central

    Herrera, Antonio; Ibarz, Elena; Cegoñino, José; Lobo-Escolar, Antonio; Puértolas, Sergio; López, Enrique; Mateo, Jesús; Gracia, Luis

    2012-01-01

    Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography (CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element (FE) simulation lets us know the biomechanical changes that take place after hip prostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints

  13. Sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease.

    PubMed

    Gautschi, Oliver P; Corniola, Marco V; Smoll, Nicolas R; Joswig, Holger; Schaller, Karl; Hildebrandt, Gerhard; Stienen, Martin N

    2016-05-01

    Sex differences in pain perception are known to exist; however, the exact pathomechanism remains unclear. This work aims to elucidate sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life (HRQoL) in patients with lumbar degenerative disc disease. In a prospective 2-center study, back and leg pain (visual analogue scale [VAS]), functional disability (Oswestry Disability Index and Roland-Morris Disability Index), and HRQoL (EuroQol-5D and Short Form [SF12]) were collected for consecutive patients undergoing lumbar spine surgery. Objective functional impairment (OFI) was estimated using age-adjusted and sex-adjusted cutoff values for the timed-up-and-go (TUG) test. A healthy cohort of n = 110 subjects served as the control group. Univariate and multivariate analyses were performed to test the association between sex and pain, subjective and OFIs, and HRQoL. The study comprised n = 305 patients (41.6% females). Female patients had more VAS back pain (P = 0.002) and leg pain (P = 0.014). They were more likely to report higher functional impairment in terms of Oswestry Disability Index (P = 0.005). Similarly, HRQoL measured with the EuroQol-5D index (P = 0.012) and SF12 physical composite score (P = 0.005) was lower in female patients. Female patients reported higher VAS back and leg pain, functional impairment, and reduced HRQoL than male patients. However, there were no sex differences with respect to the presence and degree of OFI measured by the TUG test using age-adjusted and sex-adjusted cutoff values. As such, the TUG may be a good test to overcome sex bias for the clinical assessment of patients with degenerative disc disease.

  14. MEG-based detection and localization of perilesional dysfunction in chronic stroke

    PubMed Central

    Chu, Ron K.O.; Braun, Allen R.; Meltzer, Jed A.

    2015-01-01

    Post-stroke impairment is associated not only with structural lesions, but also with dysfunction in surviving perilesional tissue. Previous studies using equivalent current dipole source localization of MEG/EEG signals have demonstrated a preponderance of slow-wave activity localized to perilesional areas. Recent studies have also demonstrated the utility of nonlinear analyses such as multiscale entropy (MSE) for quantifying neuronal dysfunction in a wide range of pathologies. The current study utilized beamformer-based reconstruction of signals in source space to compare spectral and nonlinear measures of electrical activity in perilesional and healthy cortices. Data were collected from chronic stroke patients and healthy controls, both young and elderly. We assessed relative power in the delta (1–4 Hz), theta (4–7 Hz), alpha (8–12 Hz) and beta (15–30 Hz) frequency bands, and also measured the nonlinear complexity of electrical activity using MSE. Perilesional tissue exhibited a general slowing of the power spectrum (increased delta/theta, decreased beta) as well as a reduction in MSE. All measures tested were similarly sensitive to changes in the posterior perilesional regions, but anterior perilesional dysfunction was detected better by MSE and beta power. The findings also suggest that MSE is specifically sensitive to electrophysiological dysfunction in perilesional tissue, while spectral measures were additionally affected by an increase in rolandic beta power with advanced age. Furthermore, perilesional electrophysiological abnormalities in the left hemisphere were correlated with the degree of language task-induced activation in the right hemisphere. Finally, we demonstrate that single subject spectral and nonlinear analyses can identify dysfunctional perilesional regions within individual patients that may be ideal targets for interventions with noninvasive brain stimulation. PMID:26106540

  15. On the Relationship Between 'Universal' and 'Particular' in Architecture.

    PubMed

    Arenghi, Alberto; Garofolo, Ilaria; Laurìa, Antonio

    2016-01-01

    In 1998 Molly Follette Story, James Mueller and Roland Mace published the book The Universal Design File; that can be considered the result of a long way, started by Mace in 1985, towards a design approach based on the principles of Universal Design. In 2010 the Centre for Active Design publishes the Active Design Guidelines: Promoting Physical Activity and Health in Design. Between these two milestones, this article offers some ideas about the evolution of the universal approach to design. Assuming that Universal Design approach can present limits, this article aims to reflect on the relationship between universal and particular in developing a theoretical approach to architecture and design, supporting the idea that the wide gray area of the population who need specific access solutions can find answers to their needs only through successive adjustments, time by time plugged on universal solutions. This implies a process of requirement-based retrofitting of existing spaces and goods, to get qualities or perfecting performances otherwise inadequate. From this perspective the project for accessibility should be seen as a never ending process, and not a fix and final product, and Universal Design should be considered as a methodological approach ideally tending towards accessibility as a goal. Having this in mind, the article explores the issues related to how to blend universal and particular in a human centred design strategy, how to combine design actions and awareness by the users to allow an effective mutual adaptation between people and their living environment. The article aims to be further food for thought regarding research to be implemented in future works.

  16. Minutes of the meeting of the international program committee

    NASA Astrophysics Data System (ADS)

    2012-12-01

    The meeting of the International Program Committee occurred on 5 June 2012. The agenda consisted of the following items: - Information on conference participants, contributions and grants - Information on the financial support received by the conference - Committee membership - Organizers of the next two meeting of the ICSLS Conference participants and contributions There were about 100 registered participants for the ICSLS. They presented more than 100 contributions, namely, 19 invited talks, 20 oral contributions and more than 61 contributed papers. It was noted that only very few participants came from North America. Reasons quoted were finacial problems of laboratories and overlapping of several conferences. Finacial support received The conference received grants from St. Petersburg University, the Russian Foundation for Basic Research, and the non-profit Dynasty Foundation. About 40% of the budget was collected in the form of registration fees. Discounted fees and fee waives were provided for 40 participants. Committee membership The Committee instructed Professor A Devdariani to contact the absent members who had missed two successive conferences and ask them whether they intended to prolong their membership on the Committee, and inform other Committee members accordingly. Organizers of the next meetings of the ICSLS The 20th ICSLS held in St. John's, Newfoundland, Canada decided to hold the 22nd ICSLS at the University of Tennessee. The event will be organized by Christian Parriger. All issues regarding the next conference were discussed including budget, travel, conference site, accommodation, and proceedings. Torun, Poland was proposed for the 23d ICSLS by Roman Ciurylo. Roland Stamm proposed the Aix-Marseille University as a backup to the first proposal.

  17. Kinematic and Neurophysiological Consequences of an Assisted-Force-Feedback Brain-Machine Interface Training: A Case Study

    PubMed Central

    Silvoni, Stefano; Cavinato, Marianna; Volpato, Chiara; Cisotto, Giulia; Genna, Clara; Agostini, Michela; Turolla, Andrea; Ramos-Murguialday, Ander; Piccione, Francesco

    2013-01-01

    In a proof-of-principle prototypical demonstration we describe a new type of brain-machine interface (BMI) paradigm for upper limb motor-training. The proposed technique allows a fast contingent and proportionally modulated stimulation of afferent proprioceptive and motor output neural pathways using operant learning. Continuous and immediate assisted-feedback of force proportional to rolandic rhythm oscillations during actual movements was employed and illustrated with a single case experiment. One hemiplegic patient was trained for 2 weeks coupling somatosensory brain oscillations with force-field control during a robot-mediated center-out motor-task whose execution approaches movements of everyday life. The robot facilitated actual movements adding a modulated force directed to the target, thus providing a non-delayed proprioceptive feedback. Neuro-electric, kinematic, and motor-behavioral measures were recorded in pre- and post-assessments without force assistance. Patient’s healthy arm was used as control since neither a placebo control was possible nor other control conditions. We observed a generalized and significant kinematic improvement in the affected arm and a spatial accuracy improvement in both arms, together with an increase and focalization of the somatosensory rhythm changes used to provide assisted-force-feedback. The interpretation of the neurophysiological and kinematic evidences reported here is strictly related to the repetition of the motor-task and the presence of the assisted-force-feedback. Results are described as systematic observations only, without firm conclusions about the effectiveness of the methodology. In this prototypical view, the design of appropriate control conditions is discussed. This study presents a novel operant-learning-based BMI-application for motor-training coupling brain oscillations and force feedback during an actual movement. PMID:24223567

  18. Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia

    PubMed Central

    Wu, Chao; Zheng, Yingjun; Li, Juanhua; Zhang, Bei; Li, Ruikeng; Wu, Haibo; She, Shenglin; Liu, Sha; Peng, Hongjun; Ning, Yuping; Li, Liang

    2017-01-01

    Under a “cocktail-party” listening condition with multiple-people talking, compared to healthy people, people with schizophrenia benefit less from the use of visual-speech (lipreading) priming (VSP) cues to improve speech recognition. The neural mechanisms underlying the unmasking effect of VSP remain unknown. This study investigated the brain substrates underlying the unmasking effect of VSP in healthy listeners and the schizophrenia-induced changes in the brain substrates. Using functional magnetic resonance imaging, brain activation and functional connectivity for the contrasts of the VSP listening condition vs. the visual non-speech priming (VNSP) condition were examined in 16 healthy listeners (27.4 ± 8.6 years old, 9 females and 7 males) and 22 listeners with schizophrenia (29.0 ± 8.1 years old, 8 females and 14 males). The results showed that in healthy listeners, but not listeners with schizophrenia, the VSP-induced activation (against the VNSP condition) of the left posterior inferior temporal gyrus (pITG) was significantly correlated with the VSP-induced improvement in target-speech recognition against speech masking. Compared to healthy listeners, listeners with schizophrenia showed significantly lower VSP-induced activation of the left pITG and reduced functional connectivity of the left pITG with the bilateral Rolandic operculum, bilateral STG, and left insular. Thus, the left pITG and its functional connectivity may be the brain substrates related to the unmasking effect of VSP, assumedly through enhancing both the processing of target visual-speech signals and the inhibition of masking-speech signals. In people with schizophrenia, the reduced unmasking effect of VSP on speech recognition may be associated with a schizophrenia-related reduction of VSP-induced activation and functional connectivity of the left pITG. PMID:28360829

  19. Comparative study of the fermentative characteristics of inulin and different types of fibre in rats inoculated with a human whole faecal flora.

    PubMed

    Roland, N; Nugon-Baudon, L; Andrieux, C; Szylit, O

    1995-08-01

    It is known that the physico-chemical characteristics of fibre modify their fermentation characteristics in the colon. Previously we showed the varying effects of inulin and different types of fibre on the hepatic and intestinal xenobiotic-metabolizing enzymes (XME) in initially germ-free rats inoculated with a human, methanogenic, whole-faecal flora (Roland et al. 1994). The aim of the present work was to assess whether or not these effects could be related to differences in production of fermentation metabolites (gases excreted in vivo and caecal metabolites) due to the different compositions of fibre. The different types of fibres were analysed with regard to their solubility and their composition of neutral monomers and uronic acids. Inulin was totally soluble, carrot (Daucus carota), cocoa (Theobroma cacao) and wheat bran were partially soluble; pea (Pisum sativum) and oat were nearly totally insoluble. Uronic acids were found mostly in carrot and cocoa fibre. Glucose was present as the main neutral monomer in each fibre type. Xylose was found also in wheat bran, pea and oat fibres, and arabinose was found in wheat bran. Inulin consumption led to high levels of H2 production but no CH4 production, to a 4-fold greater caecal concentration of butyrate than with the other fibres and to a decrease in caecal pH. Conversely, rats fed on carrot or cocoa fibre produced a large amount of CH4 but no H2 and generated a different profile of short-chain fatty acids (SCFA). The lowest amounts of gases and SCFA were found in rats fed on wheat bran, pea and oat fibre. We observed a relationship between the caecal concentration of SCFA and the activity of hepatic glutathione-S-transferase (EC 2.5.1.18) but no direct link was shown between the other XME and the fermentation profile.

  20. Results of a Randomized Controlled Trial to Examine the Efficacy of a Chronic Pain Self-Management Group for Older Adults [ISRCTN11899548

    PubMed Central

    Ersek, Mary; Turner, Judith A.; Cain, Kevin C.; Kemp, Carol A.

    2008-01-01

    Chronic pain is a common, disabling problem in older adults. Pain self-management training is a multimodal therapy that has been found to be effective in young to middle-aged adult samples; however, few studies have examined the effectiveness of this therapy in older adults. In this randomized, controlled trial, we evaluated a pain self-management training group (SMG) intervention as compared with an education-only (BOOK) control condition. Participants, 65 years of age or older who experienced persistent, noncancer pain that limited their activities, were recruited from 43 retirement communities in the Pacific Northwest of the United States. The primary outcome was physical disability, as measured by the Roland-Morris Disability Questionnaire. Secondary outcomes were depression (Geriatric Depression Scale), pain intensity (Brief Pain Inventory), and pain-related interference with activities (Brief Pain Inventory). Randomization occurred by facility to minimize cross-contamination between groups. Two-hundred and fifty-six individuals, mean age=81.8 (SD: 6.5), enrolled and 218 completed the study. No significant differences in outcomes were found between groups at post-intervention, 6-month follow-up, or 12-month follow-up. The SMG group showed a significantly greater increase over time, relative to the BOOK group, in two process measures, as measured by the Chronic Pain Coping Inventory: use of relaxation and use of exercise/stretching. In both cases, the increase was greatest from baseline to the post-intervention assessment. Study findings indicate that additional research is needed to determine the most effective content and delivery methods for self-management therapies targeted at older adults with chronic pain. PMID:18086516

  1. Eccentricity-dependent changes in local onset and offset responses in patients with progressive cone dystrophy.

    PubMed

    Holopigian, K; Wynn, P; Seiple, W; Carr, R E; Hood, D C

    2007-08-01

    Shinoda and colleagues hypothesized that patients with cone dystrophy (CD) might suffer from a selective ON-system deficit, based on the local nature of the disease [Shinoda, K, Ohde, H, Inoue, R, Ishida, S, Mashima, Y, & Oguchi, Y (2002). ON-pathway disturbance in two siblings. Acta Ophthalmologica Scandinavica, 80, 219-223]. The purpose of the current study was to test this hypothesis by examining onset and offset responses as a function of eccentricity in a group of patients with CD using long-duration LED stimuli. Nine patients with CD participated in this study (mean age of 36.1 years and visual acuity 20/200). For this study, the following measures were obtained: Humphrey threshold visual fields, standard multifocal ERGs (mfERGs) as well as mfERGs to long duration stimuli recorded using the Retiscan stimulator (Roland Instruments). This display contained 61 scaled hexagons and the LEDs were on for 100ms (180cd/m(2)) and off for 100ms. In addition, standard full-field photopic and flicker ERGs using Ganzfeld stimulation were obtained. For the control subjects, the onset responses were larger than the offset responses at all eccentricities; whereas for the patients, there was overlap between the amplitudes of the onset and offset responses. For the patients, the amplitude ratios (relative to the control data) indicated that the difference between the onset and offset responses was greatest for the central-most ring and this difference decreased with increasing eccentricity. For the onset responses, Humphrey thresholds and mfERG amplitudes, performance was poorest for the center ring and best for the most peripheral ring; for the offset responses, the opposite pattern of results was obtained. The differences in the pattern of results in the long duration mfERG data are consistent with a selective loss of the onset responses in our patient population.

  2. Neuroscience education in addition to trigger point dry needling for the management of patients with mechanical chronic low back pain: A preliminary clinical trial.

    PubMed

    Téllez-García, Mario; de-la-Llave-Rincón, Ana I; Salom-Moreno, Jaime; Palacios-Ceña, Maria; Ortega-Santiago, Ricardo; Fernández-de-Las-Peñas, César

    2015-07-01

    The objective of the current study was to determine the short-term effects of trigger point dry needling (TrP-DN) alone or combined with neuroscience education on pain, disability, kinesiophobia and widespread pressure sensitivity in patients with mechanical low back pain (LBP). Twelve patients with LBP were randomly assigned to receive either TrP-DN (TrP-DN) or TrP-DN plus neuroscience education (TrP-DN + EDU). Pain intensity (Numerical Pain Rating Scale, 0-10), disability (Roland-Morris Disability Questionnaire-RMQ-, Oswestry Low Back Pain Disability Index-ODI), kinesiophobia (Tampa Scale of Kinesiophobia-TSK), and pressure pain thresholds (PPT) over the C5-C6 zygapophyseal joint, transverse process of L3 vertebra, second metacarpal, and tibialis anterior muscle were collected at baseline and 1-week after the intervention. Patients treated with TrP-DN + EDU experienced a significantly greater reduction of kinesiophobia (P = 0.008) and greater increases in PPT over the transverse process of L3 (P = 0.049) than those patients treated only with TrP-DN. Both groups experienced similar decreases in pain, ODI and RMQ, and similar increases in PPT over the C5/C6 joint, second metacarpal, and tibialis anterior after the intervention (all, P > 0.05). The results suggest that TrP-DN was effective for improving pain, disability, kinesiophobia and widespread pressure sensitivity in patients with mechanical LBP at short-term. The inclusion of a neuroscience educational program resulted in a greater improvement in kinesiophobia.

  3. The logical interpretation and the measurement problem

    NASA Astrophysics Data System (ADS)

    Vuletic, Mark I.

    The measurement problem is one of the two key problems in the foundations of quantum mechanics, carrying with it the seeming implication that instead of the familiar definite states of affairs we think we experience, there typically should exist only phenomenologically ill-defined "superpositions" of such states of affairs. Dissatisfaction with this implication has led to the development of many wildly different interpretations of quantum mechanics, positing everything from pilot waves to splitting universes. A recent tradition of interpretation draws heavily upon decoherence and a "consistent histories" formalism to try to resolve the standard conceptual problems of quantum mechanics. Roland Omnes, one physicist in this tradition, argues that his own "logical interpretation" resolves every paradox and conceptual difficulty raised by quantum mechanics, except for what he calls the "objectification problem." Figuring out what relation the objectification problem has to the measurement problem, and, more generally, what the logical interpretation has to say about the measurement problem, turns out to be very difficult, even with the benefit of correspondence. In my dissertation, I have tried to narrow down the possibilities for what Omnes might have in mind with respect to the measurement problem, and considered whether any of these constitutes an advance over what came before. I conclude that there are two plausible possibilities: either (i) an overly aggressive pragmatic spirit has caused Omnes to fail to even realize that a critical part of the measurement problem exists, or (ii) the logical interpretation is best understood as offering a stochastic hidden factor interpretation, with complementarity operating at the level of the hidden factors, even though Omnes himself would resist describing the logical interpretation in this way. I also conclude that the logical interpretation, far from saving classical logic, actually undermines it. While this may not

  4. Applications of finite element simulation in orthopedic and trauma surgery.

    PubMed

    Herrera, Antonio; Ibarz, Elena; Cegoñino, José; Lobo-Escolar, Antonio; Puértolas, Sergio; López, Enrique; Mateo, Jesús; Gracia, Luis

    2012-04-18

    Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography (CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element (FE) simulation lets us know the biomechanical changes that take place after hip prostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints

  5. The effects of physical therapeutic agents on serum levels of stress hormones in patients with osteoarthritis

    PubMed Central

    Tönük, Şükrü Burak; Serin, Erdinc; Ayhan, Fikriye Figen; Yorgancioglu, Zeynep Rezan

    2016-01-01

    Abstract To investigate the effects of physical agents on the levels of stress hormones in patients with osteoarthritis (OA). Transcutaneous electrical nerve stimulation, hot packs, and therapeutic ultrasound were applied to the lumbar region and knees of patients with OA. Blood samples were taken for the measurement of the serum levels of glucose, insulin (INS), growth hormone (GH), prolactin (PRL), cortisol (COR), and plasma adrenocorticotropic hormone (ACTH) immediately before and after the 1st session, to investigate the acute effects of those physical agents on the endocrine system. The hormone levels were also measured every 5 sessions in a total of 10 sessions. The treatment response was also evaluated by using the visual analogue scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Western Ontario and McMaster Universities Arthritis Index (WOMAC) throughout the therapy period. After the 1st session, there was a decrease in INS levels and a mild decrease in PRL levels (P = 0.001 and P < 0.05, respectively). Throughout the 10-session therapy period, the INS levels increased, whereas the ACTH and COR levels decreased (P < 0.05 for all). The VAS-spine, RMDQ, VAS-knee, and WOMAC scores decreased (P = 0.001 for VAS-spine and P < 0.001 for all others). A positive correlation was detected between the changes in serum COR and WOMAC-pain score (P < 0.05). Although the combination therapy caused changes in INS level accompanied with steady glucose levels, the application of physical agents did not adversely affect the hormone levels. The decrease in ACTH and COR levels may be attributed to the analgesic effect of agents and may be an indicator of patient comfort through a central action. PMID:27583888

  6. Reduction in the amount of crosstalk with reduced number of focal spot rows in a grating array based zonal wavefront sensor

    NASA Astrophysics Data System (ADS)

    Pathak, Biswajit; Boruah, Bosanta R.

    2015-06-01

    The Shack Hartmann wavefront sensor (SHWS), named after Johannes Franz Hartmann and Roland Shack, is one of the most well-known and popularly used optical wavefront sensor that finds numerous applications in various optical technologies. SHWS samples the incident wavefront by means of a lenslet array to produce an array of regular 2D array of focal spots on the detector plane of a digital camera, in the case of an unaberrated plane wavefront. If the incident wavefront is aberrated or deviates from a plane wavefront, the respective focal spots get shifted from its reference positions corresponding to the regular grid. If the incident wavefront aberration increases or has a very large curvature, the focal spot of one lenslet may enter the detector sub-aperture of the nearby lenslet. Thus, the SHWS has a limited dynamic range that is restricted to aberrations which do not allow the sub-images to be displaced out from their own detector sub-array. It makes the SHWS sensitive to cross-talk when higher order aberrations are present thereby unavoidably a ecting the wavefront estimation process. The array of tiny lenses of the SHWS can be replaced by an array of gratings followed by a focusing lens, generating an array of focal spots which is similar to that as in the case of a SHWS. In this paper, the spatial frequency of such a grating array based zonal wavefront sensor is configured to produce lesser number of rows of focal spots. The reduction in the number of focal spot rows reduces the amount of cross talk in the vertical direction. In this paper we present preliminary experimental results to demonstrate the above stated reduction in crosstalk.

  7. Study protocol of cost-effectiveness and cost-utility of a biopsychosocial multidisciplinary intervention in the evolution of non-specific sub-acute low back pain in the working population: cluster randomised trial

    PubMed Central

    2011-01-01

    Background Low back pain (LBP), with high incidence and prevalence rate, is one of the most common reasons to consult the health system and is responsible for a significant amount of sick leave, leading to high health and social costs. The objective of the study is to assess the cost-effectiveness and cost-utility analysis of a multidisciplinary biopsychosocial educational group intervention (MBEGI) of non-specific sub-acute LBP in comparison with the usual care in the working population recruited in primary healthcare centres. Methods/design The study design is a cost-effectiveness and cost-utility analysis of a MBEGI in comparison with the usual care of non-specific sub-acute LBP. Measures on effectiveness and costs of both interventions will be obtained from a cluster randomised controlled clinical trial carried out in 38 Catalan primary health care centres, enrolling 932 patients between 18 and 65 years old with a diagnosis of non-specific sub-acute LBP. Effectiveness measures are: pharmaceutical treatments, work sick leave (% and duration in days), Roland Morris disability, McGill pain intensity, Fear Avoidance Beliefs (FAB) and Golberg Questionnaires. Utility measures will be calculated from the SF-12. The analysis will be performed from a social perspective. The temporal horizon is at 3 months (change to chronic LBP) and 12 months (evaluate the outcomes at long term). Assessment of outcomes will be blinded and will follow the intention-to-treat principle. Discussion We hope to demonstrate the cost-effectiveness and cost-utility of MBEGI, see an improvement in the patients' quality of life, achieve a reduction in the duration of episodes and the chronicity of non-specific low back pain, and be able to report a decrease in the social costs. If the intervention is cost-effectiveness and cost-utility, it could be applied to Primary Health Care Centres. Trial registration ISRCTN: ISRCTN58719694 PMID:21859489

  8. Sex differences in associations of arginine vasopressin and oxytocin with resting-state functional brain connectivity.

    PubMed

    Rubin, Leah H; Yao, Li; Keedy, Sarah K; Reilly, James L; Bishop, Jeffrey R; Carter, C Sue; Pournajafi-Nazarloo, Hossein; Drogos, Lauren L; Tamminga, Carol A; Pearlson, Godfrey D; Keshavan, Matcheri S; Clementz, Brett A; Hill, Scot K; Liao, Wei; Ji, Gong-Jun; Lui, Su; Sweeney, John A

    2017-01-02

    Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI. Men showed higher nodal degree (connectedness) and efficiency (information propagation capacity) in left inferior frontal gyrus (IFG) and bilateral superior temporal gyrus (STG) and higher nodal degree in left rolandic operculum. Women showed higher nodal betweenness (being part of paths between nodes) in right putamen and left inferior parietal gyrus (IPG). Higher hormone levels were associated with less intrinsic connectivity. In men, higher AVP was associated with lower nodal degree and efficiency in left IFG (pars orbitalis) and left STG and less efficiency in left IFG (pars triangularis). In women, higher AVP was associated with lower betweenness in left IPG, and higher OT was associated with lower nodal degree in left IFG (pars orbitalis). Hormones differentially correlate with brain networks that are important for emotion processing and cognition in men and women. AVP in men and OT in women may regulate orbital frontal cortex connectivity, which is important in emotion processing. Hormone associations with STG and pars triangularis in men and parietal cortex in women may account for well-established sex differences in verbal and visuospatial abilities, respectively. © 2016 Wiley Periodicals, Inc.

  9. fMRI study of brain activity elicited by oral parafunctional movements.

    PubMed

    Byrd, K E; Romito, L M; Dzemidzic, M; Wong, D; Talavage, T M

    2009-05-01

    Parafunctional masticatory activity, such as the tooth clenching and grinding that is associated with bruxism, is encountered by clinicians in many disciplines, including dentistry, neurology and psychiatry. Despite this, little is known about the neurological basis for these activities. To identify the brain network engaged in such complex oromotor activity, functional magnetic resonance imaging (fMRI) was used to elucidate the brain activation patterns of 20 individuals (10 males and 10 females, mean s.d. age of 26.3+/-4.1 years) with (parafunctional, PFx group, 5M/5F) and without (normal functional, NFx group, 5 M/5F) self-reported parafunctional grinding and clenching habits during clenching and grinding tasks. Subject group classification was based on: (i) self-reported history, (ii) clinical examination, (iii) evaluation of dental casts and (iv) positive responses to the temporomandibular disorder (TMD) History Questionnaire [Dworkinand LeResche, Journal of Craniomandibular Disorders, (1992) 6:301]. While subjects performed these oromotor tasks, each wore a custom-designed oral appliance minimizing head motion during imaging. Mean per cent signal changes showed significant between group differences in motor cortical (supplementary motor area, sensorimotor cortex and rolandic operculum) and subcortical (caudate) regions. Supplementary motor area data suggest that motor planning and initiation, particularly during the act of clenching, are less prominent in individuals with oromotor parafunctional behaviours. The overall extent of activated areas was reduced in subjects with self-reported parafunctional masticatory activity compared with the controls. This study's methodology and findings provide an initial step in understanding the neurological basis of parafunctional masticatory activities that are relevant for therapeutic research applications of temporomandibular joint and muscle disorders and associated comorbidities.

  10. Altered intrinsic brain activity in patients with paroxysmal kinesigenic dyskinesia by PRRT2 mutation: altered brain activity by PRRT2 mutation.

    PubMed

    Luo, ChunYan; Chen, Yongping; Song, Wei; Chen, Qin; Gong, QiYong; Shang, Hui-Fang

    2013-11-01

    The proline-rich transmembrane protein 2 (PRRT2) gene has been recently identified as a causative gene of paroxysmal kinesigenic dyskinesia (PKD), with an insertion mutation c.649_650insC (p.P217fsX7) reported as the most common mutation. However, the pathogenic mechanism of the mutation of PRRT2 remains largely unknown. Resting-state functional magnetic resonance imaging is a promising approach to assess cerebral function and reveals underlying functional changes. Resting-state functional magnetic resonance imaging was performed in 4 Chinese PKD patients with p.P217fsX7 mutation, 6 Chinese PKD patients without the mutation, and 10 healthy control subjects. Voxel-based analysis was used to characterize alterations in the amplitude of low-frequency fluctuation (ALFF). When compared with the healthy control subjects, both groups of PKD patients showed alterations in spontaneous brain activities within cortical-basal ganglia circuitry. Besides, the group of patients with p.P217fsX7 mutation also exhibited increased ALFF in the right postcenral gyrus and right rolandic operculum area, while the alteration of ALFF in group of patients without the mutation additionally involved the middle orbitofrontal cortex. Direct comparative analysis between these two patient groups revealed significantly increased ALFF in the right postcentral gyrus in the group with p.P217fsX7 mutation. Increased spontaneous brain activity in the cortical-basal ganglia circuitry, especially in the motor preparation areas, is a common pathophysiology in PKD. Differences in the spatial patterns of increased ALFF between patients with and those without the mutation might reflect the distinct pathological mechanism resulting from PRRT2 mutation.

  11. Kinesio Taping® is not better than placebo in reducing pain and disability in patients with chronic non-specific low back pain: a randomized controlled trial

    PubMed Central

    Luz, Maurício A.; Sousa, Manoel V.; Neves, Luciana A. F. S.; Cezar, Aline A. C.; Costa, Leonardo O. P.

    2015-01-01

    Background: Kinesio Taping ® has been widely used in clinical practice. However, it is unknown whether this type of tape is more effective than placebo taping in patients with chronic lower back pain. Objective: To compare the effectiveness of Kinesio Taping ® in patients with chronic non-specific low back pain against a placebo tape and a control group. Method: This is a 3-arm, randomized controlled trial with a blinded assessor. Sixty patients with chronic non-specific low back pain were randomized into one of the three groups: Kinesio Taping ® group (n=20), Micropore® (placebo) group (n=20) and control group (n=20). Patients allocated to both the Kinesio Taping ® group and the placebo group used the different types of tape for a period of 48 hours. The control group did not receive any intervention. The outcomes measured were pain intensity (measured by an 11-point numerical rating scale) and disability (measured by the 24-item Roland Morris Disability Questionnaire). A blinded assessor measured the outcomes at baseline, 48 hours and 7 days after randomization. Results: After 48 hours, there was a statistically significant difference between the Kinesio Taping ® group versus the control group (mean between-group difference = -3.1 points, 95% CI=-5.2 to -1.1, p=0.003), but no difference when compared to the placebo group (mean between-group difference= 1.9 points, 95% CI=-0.2 to 3.9, p=0.08). For the other outcomes no differences were observed. Conclusions: The Kinesio Taping ® is not better than placebo (Micropore®) in patients with chronic low back pain. PMID:26647750

  12. Mesotherapy versus Systemic Therapy in the Treatment of Acute Low Back Pain: A Randomized Trial

    PubMed Central

    Costantino, Cosimo; Marangio, Emilio; Coruzzi, Gabriella

    2011-01-01

    Pharmacological therapy of back pain with analgesics and anti-inflammatory drugs is frequently associated with adverse effects, particularly in the elderly. Aim of this study was to compare mesotherapic versus conventional systemic administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids in patients with acute low back pain. Eighty-four patients were randomized to receive anti-inflammatory therapy according to the following protocols: (a) mesotherapy group received the 1st and 4th day 2% lidocaine (1 mL) + ketoprofen 160 mg (1 mL) + methylprednisolone 40 mg (1 mL), then on 7th, 10th, and 13th day, 2% lidocaine (1 mL) + ketoprofen 160 mg (1 mL) + methylprednisolone 20 mg (1 mL) (b) conventional therapy group received ketoprofen 80 mg × 2/die and esomeprazole 20 mg/die orally for 12 days, methylprednisolone 40 mg/die intramuscularly for 4 days, followed by methylprednisolone 20 mg/die for 3 days, and thereafter, methylprednisolone 20 mg/die at alternate days. Pain intensity and functional disability were assessed at baseline (T0), at the end of treatment (T1), and 6 months thereafter (T2) by using visual analogic scale (VAS) and Roland-Morris disability questionnaire (RMDQ). In both groups, VAS and RMDQ values were significantly reduced at the end of drug treatment and after 6 months, in comparison with baseline. No significant differences were found between the two groups. This suggests that mesotherapy may be a valid alternative to conventional therapy in the treatment of acute low back pain with corticosteroids and NSAIDs. PMID:20953425

  13. Additive effect of elcatonin to risedronate for chronic back pain and quality of life in postmenopausal women with osteoporosis: a randomized controlled trial.

    PubMed

    Hongo, Michio; Miyakoshi, Naohisa; Kasukawa, Yuji; Ishikawa, Yoshinori; Shimada, Yoichi

    2015-07-01

    Calcitonin has been reported to reduce acute and chronic back pain in osteoporotic patients. The additive effect of calcitonin with a bisphosphonate on chronic back pain remains unclear. The purpose of this study was to evaluate the effect of combining elcatonin (eel calcitonin) with risedronate for patients with chronic back pain. Forty-five postmenopausal women diagnosed as having osteoporosis with chronic back pain persisting for more than 3 months, after excluding women with fresh vertebral fractures within the last 6 months, were randomly allocated to a risedronate group (risedronate alone, n = 22) and a combined group (risedronate and elcatonin, n = 23). The study period was 6 months. Pain was evaluated with a visual analogue scale (VAS) and the Roland-Morris questionnaire (RDQ). Back extensor strength, bone mineral density, and quality of life on the SF-36 and the Japanese osteoporosis quality of life score were also evaluated. Significant improvements were found in the combined group for VAS at final follow-up compared with baseline and 3 months, mental health status on the SF-36, and JOQOL domains for back pain and general health. The JOQOL domain for back pain improved significantly, but no change was found in the VAS or other domains in the risedronate group. Bone mineral density increased significantly in the two groups, but no significant difference was found between the groups. Back extensor strength did not change in both groups. In conclusion, the use of elcatonin in addition to risedronate for more than 3 months reduced chronic back pain. The additional therapy of risedronate with elcatonin may be a useful and practical choice for the treatment of osteoporosis with chronic back pain persisting more than 3 months.

  14. A voxel-based morphometry (VBM) analysis of regional grey and white matter volume abnormalities within the speech production network of children who stutter.

    PubMed

    Beal, Deryk S; Gracco, Vincent L; Brettschneider, Jane; Kroll, Robert M; De Nil, Luc F

    2013-09-01

    It is well documented that neuroanatomical differences exist between adults who stutter and their fluently speaking peers. Specifically, adults who stutter have been found to have more grey matter volume (GMV) in speech relevant regions including inferior frontal gyrus, insula and superior temporal gyrus (Beal et al., 2007; Song et al., 2007). Despite stuttering having its onset in childhood only one study has investigated the neuroanatomical differences between children who do and do not stutter. Chang et al. (2008) reported children who stutter had less GMV in the bilateral inferior frontal gyri and middle temporal gyrus relative to fluently speaking children. Thus it appears that children who stutter present with unique neuroanatomical abnormalities as compared to those of adults who stutter. In order to better understand the neuroanatomical correlates of stuttering earlier in its development, near the time of onset, we used voxel-based morphometry to examine volumetric differences between 11 children who stutter and 11 fluent children. Children who stutter had less GMV in the bilateral inferior frontal gyri and left putamen but more GMV in right Rolandic operculum and superior temporal gyrus relative to fluent children. Children who stutter also had less white matter volume bilaterally in the forceps minor of the corpus callosum. We discuss our findings of widespread anatomic abnormalities throughout the cortical network for speech motor control within the context of the speech motor skill limitations identified in people who stutter (Namasivayam and van Lieshout, 2008; Smits-Bandstra et al., 2006).

  15. The Importance of Synchrony and Temporal Order of Visual and Tactile Input for Illusory Limb Ownership Experiences – An fMRI Study Applying Virtual Reality

    PubMed Central

    Diers, Martin; Kamping, Sandra; Rance, Mariela; Kirsch, Pinar; Trojan, Jörg; Fuchs, Xaver; Bach, Felix; Çakmak, Hüseyin Kemal; Maaß, Heiko; Flor, Herta

    2014-01-01

    In the so-called rubber hand illusion, synchronous visuotactile stimulation of a visible rubber hand together with one's own hidden hand elicits ownership experiences for the artificial limb. Recently, advanced virtual reality setups were developed to induce a virtual hand illusion (VHI). Here, we present functional imaging data from a sample of 25 healthy participants using a new device to induce the VHI in the environment of a magnetic resonance imaging (MRI) system. In order to evaluate the neuronal robustness of the illusion, we varied the degree of synchrony between visual and tactile events in five steps: in two conditions, the tactile stimulation was applied prior to visual stimulation (asynchrony of −300 ms or −600 ms), whereas in another two conditions, the tactile stimulation was applied after visual stimulation (asynchrony of +300 ms or +600 ms). In the fifth condition, tactile and visual stimulation was applied synchronously. On a subjective level, the VHI was successfully induced by synchronous visuotactile stimulation. Asynchronies between visual and tactile input of ±300 ms did not significantly diminish the vividness of illusion, whereas asynchronies of ±600 ms did. The temporal order of visual and tactile stimulation had no effect on VHI vividness. Conjunction analyses of functional MRI data across all conditions revealed significant activation in bilateral ventral premotor cortex (PMv). Further characteristic activation patterns included bilateral activity in the motion-sensitive medial superior temporal area as well as in the bilateral Rolandic operculum, suggesting their involvement in the processing of bodily awareness through the integration of visual and tactile events. A comparison of the VHI-inducing conditions with asynchronous control conditions of ±600 ms yielded significant PMv activity only contralateral to the stimulation site. These results underline the temporal limits of the induction of limb ownership related to

  16. The ASIBIA sea-ice facility: First results from the Atmosphere-Sea-Ice-Biogeochemistry in the Arctic chamber

    NASA Astrophysics Data System (ADS)

    France, James L.; Thomas, Max

    2016-04-01

    Working in the natural ocean-ice-atmosphere system is very difficult, as conducting fieldwork on sea-ice presents many challenges ice including costs, safety, experimental controls and access. The new ASIBIA (Atmosphere-Sea-Ice-Biogeochemistry in the Arctic) coupled Ocean-Sea-Ice-(Snow)-Atmosphere chamber facility at the University of East Anglia, UK, we are aiming to perform controlled first-year sea-ice investigations in areas such as sea-ice physics, physicochemical and biogeochemical processes in sea-ice and quantification of the bi-directional flux of gases in various states of first-year sea-ice conditions. The facility is a medium sized chamber with programmable temperatures from -55°C to +30°C, allowing a full range of first year sea-ice growing conditions in both the Arctic and Antarctic to be simulated. The water depth can be up to 1 m (including up to 25 cm of sea-ice) and an optional 1 m tall Teflon film atmosphere on top of the sea-ice, thus creating a closed and coupled ocean-sea-ice-atmosphere mesocosm. Ice growth in the tank is well suited for studying first-year sea-ice physical properties, with in-situ ice-profile measurements of temperature, salinity, conductivity, pressure and spectral light transmission. Underwater and above ice cameras are installed to record the physical development of the sea-ice. Here, we present the data from the first suites of experiments in the ASIBIA chamber focussing on sea-ice physics and give a brief description of the capabilities of the facility going forward. The ASIBIA chamber was funded as part of an ERC consolidator grant to the late Prof. Roland von Glasow and we hope this work and further development of the facility will act as a lasting legacy.

  17. Whole-Brain Analysis of Amyotrophic Lateral Sclerosis by Using Echo-Planar Spectroscopic Imaging

    PubMed Central

    Verma, Gaurav; Woo, John H.; Chawla, Sanjeev; Wang, Sumei; Sheriff, Sulaiman; Elman, Lauren B.; McCluskey, Leo F.; Grossman, Murray; Melhem, Elias R.; Maudsley, Andrew A.

    2013-01-01

    Purpose: To detect regional metabolic differences in amyotrophic lateral sclerosis (ALS) with whole-brain echo-planar spectroscopic imaging. Materials and Methods: Sixteen patients with ALS (nine men, seven women; mean age, 56.6 years), five persons suspected of having ALS (four men, one woman; mean age, 62.6 years), and 10 healthy control subjects (five men, five women; mean age, 56.1 years) underwent echo-planar spectroscopic imaging after providing informed consent. The study was approved by the institutional review board and complied with HIPAA. Data were analyzed with the Metabolic Imaging and Data Analysis System software, and processed metabolite maps were coregistered and normalized to a standard brain template. Metabolite maps of creatine (Cr), choline (Cho), and N-acetylaspartate (NAA) were segmented into 81 regions with Automated Anatomical Labeling software to measure metabolic changes throughout the brains of patients with ALS. Statistical analysis involved an unpaired, uncorrected, two-sided Student t test. Results: The NAA/Cho ratio across six regions was significantly lower by a mean of 23% (P ≤ .01) in patients with ALS than in control subjects. These regions included the caudate, lingual gyrus, supramarginal gyrus, and right and left superior and right inferior occipital lobes. The NAA/Cr ratio was significantly lower (P ≤ .01) in eight regions in the patient group, by a mean of 16%. These included the caudate, cuneus, frontal inferior operculum, Heschl gyrus, precentral gyrus, rolandic operculum, and superior and inferior occipital lobes. The Cho/Cr ratio did not significantly differ in any region between patient and control groups. Conclusion: Whole-brain echo-planar spectroscopic imaging permits detection of regional metabolic abnormalities in ALS, including not only the motor cortex but also several other regions implicated in ALS pathophysiologic findings. © RSNA, 2013 PMID:23360740

  18. Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up?

    PubMed

    Ashworth, Julie; Green, Daniel J; Dunn, Kate M; Jordan, Kelvin P

    2013-07-01

    Opioid prescribing for chronic noncancer pain is increasing, but there is limited knowledge about longer-term outcomes of people receiving opioids for conditions such as back pain. This study aimed to explore the relationship between prescribed opioids and disability among patients consulting in primary care with back pain. A total of 715 participants from a prospective cohort study, who gave consent for review of medical and prescribing records and completed baseline and 6month follow-up questionnaires, were included. Opioid prescription data were obtained from electronic prescribing records, and morphine equivalent doses were calculated. The primary outcome was disability (Roland-Morris Disability Questionnaire [RMDQ]) at 6months. Multivariable linear regression was used to examine the association between opioid prescription at baseline and RMDQ score at 6months. Analyses were adjusted for potential confounders using propensity scores reflecting the probability of opioid prescription given baseline characteristics. In the baseline period, 234 participants (32.7%) were prescribed opioids. In the final multivariable analysis, opioid prescription at baseline was significantly associated with higher disability at 6-month follow-up (P<.022), but the magnitude of this effect was small, with a mean RMDQ score of 1.18 (95% confidence interval: 0.17 to 2.19) points higher among those prescribed opioids compared to those who were not. Our findings indicate that even after adjusting for a substantial number of potential confounders, opioids were associated with slightly worse functioning in back pain patients at 6-month follow-up. Further research may help us to understand the mechanisms underlying these findings and inform clinical decisions regarding the usefulness of opioids for back pain.

  19. Neurophysiological activity underlying altered brain metabolism in epileptic encephalopathies with CSWS.

    PubMed

    De Tiège, Xavier; Trotta, Nicola; Op de Beeck, Marc; Bourguignon, Mathieu; Marty, Brice; Wens, Vincent; Nonclercq, Antoine; Goldman, Serge; Van Bogaert, Patrick

    2013-08-01

    We investigated the neurophysiological correlate of altered regional cerebral glucose metabolism observed in children with epileptic encephalopathy with continuous spike-waves during sleep (CSWS) by using a multimodal approach combining time-sensitive magnetic source imaging (MSI) and positron emission tomography with [(18)F]-fluorodeoxyglucose (FDG-PET). Six patients (4 boys and 2 girls, age range: 4-8 years, 3 patients with Landau-Kleffner syndrome (LKS), 3 patients with atypical rolandic epilepsy (ARE)) were investigated by FDG-PET and MSI at the acute phase of CSWS. In all patients, the onset(s) of spike-waves discharges were associated with significant focal hypermetabolism. The propagation of epileptic discharges to other brain areas was associated with focal hypermetabolism (five patients), hypometabolism (one patient) or the absence of any significant metabolic change (one patient). Interestingly, most of the hypometabolic areas were not involved in the epileptic network per se. This study shows that focal hypermetabolism observed at the acute phase of CSWS are related to the onset or propagation sites of spike-wave discharges. Spike-wave discharges propagation can be associated to other types of metabolic changes, suggesting the occurrence of various neurophysiological mechanisms at the cellular level. Most of the hypometabolic areas are not involved in the epileptic network as such and are probably related to a mechanism of remote inhibition. These findings highlight the critical value of combining FDG-PET with time-sensitive functional neuroimaging approaches such as MSI to assess CSWS epileptic network when surgery is considered as a therapeutic approach.

  20. The intrahemispheric functional properties of the developing sensorimotor cortex are influenced by maturation.

    PubMed

    Berchicci, Marika; Tamburro, Gabriella; Comani, Silvia

    2015-01-01

    The investigation of the functional changes in the sensorimotor cortex has important clinical implications as deviations from normal development can anticipate developmental disorders. The functional properties of the sensorimotor cortex can be characterized through the rolandic mu rhythm, already present during infancy. However, how the sensorimotor network develops from early infancy to adulthood, and how sensorimotor processing contributes to the generation of perceptual-motor coupling remains largely unknown. Here, we analyzed magnetoencephalographic (MEG) data recorded in two groups of infants (11-24 and 26-47 weeks), two groups of children (24-34 and 36-60 months), and a control group of adults (20-39 years), during intermixed conditions of rest and prehension. The MEG sensor array was positioned over the sensorimotor cortex of the contralateral hemisphere. We characterized functional connectivity and topological properties of the sensorimotor network across ages and conditions through synchronization likelihood and segregation/integration measures in an individual mu rhythm frequency range. All functional measures remained almost unchanged during the first year of life, whereas they varied afterwards through childhood to reach adult values, demonstrating an increase of both segregation and integration properties. With age, the sensorimotor network evolved from a more random (infants) to a "small-world" organization (children and adults), more efficient both locally and globally. These findings are in line with prior studies on structural and functional brain development in infants, children and adults. We could not demonstrate any significant change in the functional properties of the sensorimotor cortex in the prehension condition with respect to rest. Our results support the view that, since early infancy, the functional properties of the developing sensorimotor cortex are modulated by maturation.

  1. Significant Efficacy of Tramadol/Acetaminophen in Elderly Patients with Chronic Low Back Pain Uncontrolled by NSAIDs: An Observational Study

    PubMed Central

    Imamura, Toshihiro

    2015-01-01

    Chronic low back pain (LBP) is a common condition and is generally treated using non-steroidal anti-inflammatory drug (NSAID); however, chronic NSAID use can decrease renal function. Tramadol, a weak opioid agonist, may improve chronic LBP and disability, while avoiding adverse effects such as gastrointestinal and renal toxicity. However, few studies have evaluated the short-term efficacy of opioids in Asian patients with chronic LBP. In this study, 24 patients with chronic LBP unresponsive to NSAIDs (10 men, 14 women; mean age, 65.1 ± 12.1 years) were prescribed tramadol/acetaminophen (37.5 mg/325 mg; four tablets daily) for 1 month. Then, the following parameters were assessed at baseline and after 1 week and 1 month of treatment: leg pain and LBP (Visual Analog Score [VAS]); activity of daily life (Roland-Morris Disability Questionnaire [RDQ]); and disability (Oswestry Disability Index [ODI]). Leg pain resolved within 1 week (p = 0.00093); however, LBP was relieved only at 1 month (p = 0.00034). The mean RDQ (p = 0.015) and ODI (p = 0.0032) scores were improved at 1 month. A total 41.6% of patients reported nausea and floating sensation beginning tramadol/acetaminophen treatment, and 12.5% (four patients) discontinued treatment as a result. LBP did not improve in 25% of patients administered tramadol/acetaminophen. Because this was an observational study, rather than a comparative study, further investigation is needed to evaluate the long-term efficacy of tramadol/acetaminophen in elderly patients with chronic LBP unresponsive to NSAIDs. PMID:26157527

  2. Comparing Once- versus Twice-Weekly Yoga Classes for Chronic Low Back Pain in Predominantly Low Income Minorities: A Randomized Dosing Trial

    PubMed Central

    Saper, Robert B.; Boah, Ama R.; Keosaian, Julia; Cerrada, Christian; Weinberg, Janice; Sherman, Karen J.

    2013-01-01

    Background. Previous studies have demonstrated that once-weekly yoga classes are effective for chronic low back pain (cLBP) in white adults with high socioeconomic status. The comparative effectiveness of twice-weekly classes and generalizability to racially diverse low income populations are unknown. Methods. We conducted a 12-week randomized, parallel-group, dosing trial for 95 adults recruited from an urban safety-net hospital and five community health centers comparing once-weekly (n = 49) versus twice-weekly (n = 46) standardized yoga classes supplemented by home practice. Primary outcomes were change from baseline to 12 weeks in pain (11-point scale) and back-related function (23-point modified Roland-Morris Disability Questionnaire). Results. 82% of participants were nonwhite; 77% had annual household incomes <$40,000. The sample's baseline mean pain intensity [6.9 (SD 1.6)] and function [13.7 (SD 5.0)] reflected moderate to severe back pain and impairment. Pain and back-related function improved within both groups (P < 0.001). However, there were no differences between once-weekly and twice-weekly groups for pain reduction [−2.1 (95% CI −2.9, −1.3) versus −2.4 (95% CI −3.1, −1.8), P = 0.62] or back-related function [−5.1 (95% CI −7.0, −3.2) versus −4.9 (95% CI −6.5, −3.3), P = 0.83]. Conclusions. Twelve weeks of once-weekly or twice-weekly yoga classes were similarly effective for predominantly low income minority adults with moderate to severe chronic low back pain. This trial is registered with ClinicalTrials.gov NCT01761617. PMID:23878604

  3. Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

    PubMed Central

    Kocur, Piotr

    2014-01-01

    Objective. To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID). Design. Prospective controlled randomized single blinded trial. Settings. Ambulatory care of rehabilitation. Participants. 59 patients, age 51.8 ± 9.0 years, with chronic low back pain. Interventions. 2 weeks of DTM in the treatment group (TG) versus 2 weeks of DTM combined with NSAID in the control group (CG). Main Outcome Measures. Visual analogue scale, Oswestry disability index (ODI), and Roland-Morris questionnaire (RM). Results. In both the TG and the CG, a significant pain reduction and function improvement were observed. VAS decreased from 58.3 ± 18.2 to 42.2 ± 21.1 (TG) and from 51.8 ± 18.8 to 30.6 ± 21.9 (CG). RM value decreased from 9.8 ± 5.1 to 6.4 ± 4.4 (TG), and from 9.3 ± 5.5 to 6.1 ± 4.6 (CG). ODI value decreased from 29.2 ± 17.3 to 21.4 ± 15.1 (TG) and from 21.4 ± 9.4 to 16.6 ± 9.4 (CG). All pre-post-treatment differences were significant; however, there was no significant difference between the TG and the CG. Conclusion. DTM had a positive effect on reducing pain in patients with chronic low back pain. Concurrent use of DTM and NSAID contributed to low back pain reduction in a similar degree that the DTM did. PMID:24707200

  4. Lesion correlates of impairments in actual tool use following unilateral brain damage.

    PubMed

    Salazar-López, E; Schwaiger, B J; Hermsdörfer, J

    2016-04-01

    To understand how the brain controls actions involving tools, tests have been developed employing different paradigms such as pantomime, imitation and real tool use. The relevant areas have been localized in the premotor cortex, the middle temporal gyrus and the superior and inferior parietal lobe. This study employs Voxel Lesion Symptom Mapping to relate the functional impairment in actual tool use with extent and localization of the structural damage in the left (LBD, N=31) and right (RBD, N=19) hemisphere in chronic stroke patients. A series of 12 tools was presented to participants in a carousel. In addition, a non-tool condition tested the prescribed manipulation of a bar. The execution was scored according to an apraxic error scale based on the dimensions grasp, movement, direction and space. Results in the LBD group show that the ventro-dorsal stream constitutes the core of the defective network responsible for impaired tool use; it is composed of the inferior parietal lobe, the supramarginal and angular gyrus and the dorsal premotor cortex. In addition, involvement of regions in the temporal lobe, the rolandic operculum, the ventral premotor cortex and the middle occipital gyrus provide evidence of the role of the ventral stream in this task. Brain areas related to the use of the bar largely overlapped with this network. For patients with RBD data were less conclusive; however, a trend for the involvement of the temporal lobe in apraxic errors was manifested. Skilled bar manipulation depended on the same temporal area in these patients. Therefore, actual tool use depends on a well described left fronto-parietal-temporal network. RBD affects actual tool use, however the underlying neural processes may be more widely distributed and more heterogeneous. Goal directed manipulation of non-tool objects seems to involve very similar brain areas as tool use, suggesting that both types of manipulation share identical processes and neural representations.

  5. The Effectiveness of Oral Corticosteroids for Management of Lumbar Radiating Pain: Randomized, Controlled Trial Study

    PubMed Central

    Kim, Sungguk; Kim, Jaejung; Oh, Taebum

    2016-01-01

    Background Although both pregabalin and gabapentin are known to be useful for treating lumbar radiating pain and reducing the incidence of surgery, the oral corticosteroids sometimes offer a dramatic effect on severe radiating pain despite the lack of scientific evidence. Methods A total of 54 patients were enrolled among 703 patients who complained of lumbar radiating pain. Twenty patients who received an oral corticosteroid was classified as group A and 20 patients who received the control drugs (pregabalin or gabapentin) as group B. Oswestry Disability Index (ODI), Revised Roland Morris disability questionnaire (RMDQ), Short Form 36 (SF-36) questionnaire, lumbar radiating pain, objective patient satisfaction, and objective improvement of patients or physicians were assessed at 2, 6, and 12 weeks after medication. Results No difference in the sex ratio and age was observed between the groups (p = 0.70 and p = 0.13, respectively). Group A showed greater improvement in radiating pain after 2, 6, and 12 weeks than group B (p < 0.001, p = 0.001, and p < 0.001, respectively). No differences were observed between the groups in satisfaction at the beginning and 12 weeks after taking the medication (p = 0.062 and p = 0.061, respectively) and in objective improvement of patients and physicians (p = 0.657 and p = 0.748, respectively). Group A was less disabled and had greater physical health scores than group B (p = 0.014 and p = 0.017, respectively). Conclusions Oral corticosteroids for the treatment of lumbar radiating pain can be more effective in pain relief than gabapentin or pregabalin. The satisfaction of patients and physicians with the drug and objective improvement status were not inferior to that with gabapentin or pregabalin. PMID:27583108

  6. Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures.

    PubMed

    Grafström, Roland C; Nymark, Penny; Hongisto, Vesa; Spjuth, Ola; Ceder, Rebecca; Willighagen, Egon; Hardy, Barry; Kaski, Samuel; Kohonen, Pekka

    2015-11-01

    This paper outlines the work for which Roland Grafström and Pekka Kohonen were awarded the 2014 Lush Science Prize. The research activities of the Grafström laboratory have, for many years, covered cancer biology studies, as well as the development and application of toxicity-predictive in vitro models to determine chemical safety. Through the integration of in silico analyses of diverse types of genomics data (transcriptomic and proteomic), their efforts have proved to fit well into the recently-developed Adverse Outcome Pathway paradigm. Genomics analysis within state-of-the-art cancer biology research and Toxicology in the 21st Century concepts share many technological tools. A key category within the Three Rs paradigm is the Replacement of animals in toxicity testing with alternative methods, such as bioinformatics-driven analyses of data obtained from human cell cultures exposed to diverse toxicants. This work was recently expanded within the pan-European SEURAT-1 project (Safety Evaluation Ultimately Replacing Animal Testing), to replace repeat-dose toxicity testing with data-rich analyses of sophisticated cell culture models. The aims and objectives of the SEURAT project have been to guide the application, analysis, interpretation and storage of 'omics' technology-derived data within the service-oriented sub-project, ToxBank. Particularly addressing the Lush Science Prize focus on the relevance of toxicity pathways, a 'data warehouse' that is under continuous expansion, coupled with the development of novel data storage and management methods for toxicology, serve to address data integration across multiple 'omics' technologies. The prize winners' guiding principles and concepts for modern knowledge management of toxicological data are summarised. The translation of basic discovery results ranged from chemical-testing and material-testing data, to information relevant to human health and environmental safety.

  7. The effects of strength exercise and walking on lumbar function, pain level, and body composition in chronic back pain patients

    PubMed Central

    Lee, Jung-Seok; Kang, Suh-Jung

    2016-01-01

    The beneficial effects of a strength exercise program and a combined exercise program of strength training plus walking were examined in overweight with chronic back pain patients. The participants were randomly placed in the strength exercise group (SEG, n=15), combined exercise group (CEG, n=15), and control group (CG, n=6). All subjects performed exercise twice per week, 50 min per session with a professional instructors for 12 weeks. In order to evaluate exercise intervention effects, lumbar function was measured by back strength and flexibility. Roland-Morris disability questionnaire (RMDQ) and visual analogue scale (VAS) were used to evaluate pain level. Fat and muscle mass were measured to compare body composition changes. All measurements were performed before and after 12 weeks of exercise program. Lumbar function: Back strength was significantly different over time, and significant time×group differences were found between SEG and CG and, CEG and CG. Pain disorder degree: VAS showed a significant group difference, and significant time×group differences were shown between SEG and CG, and CEG and CG. Also, RMDG showed a significant difference between CEG and CG. Body composition: Fat mass was significantly different over time×group between SEG and CG. In conclusion, participating in strength and walking exercises were beneficial to improve lumbar function. Also, the combined exercise program was more effective for reducing pain levels than the strength exercise. Finally, fat mass was reduced in this study and this may play a possible role in the improvement of lumbar function and reduction in low back pain. PMID:27807526

  8. Thirteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Horne, R.N.; Brigham, W.E.; Miller, F.G.; Cook, J.W.

    1988-01-21

    , Yasmin Gulamani, and Rosalee Benelli for their valued help with the meeting arrangements and preparing the Proceedings. We also owe great thanks to our students who arranged and operated the audio-visual equipment, especially Jeralyn Luetkehans. The Thirteenth Workshop was supported by the Geothermal Technology Division of the U.S. Department of Energy through Contract No. DE-AS07-84ID12529. We deeply appreciate this continued support. Henry J. Ramey, Jr. Paul Kruger Roland N. Horne William E. Brigham Frank G. Miller Jean W. Cook

  9. Analysis of the global free infra-gravity wave climate for the SWOT mission, and preliminary results of numerical modelling

    NASA Astrophysics Data System (ADS)

    Rawat, A.; Aucan, J.; Ardhuin, F.

    2012-12-01

    uses the energy balance equation, used for large scale models of swells and wind-waves, extended to periods of 100 s. The source of FIGWs energy is treated like coastal reflection (Ardhuin and Roland 2012). The amount of FIGW energy at the shoreline is crudely represented as a constant fraction of the incoming bound wave energy. The spatial and temporal variability of the modeled FIGW energy is similar to that in data from DART stations. Future work will include an estimation of seismic noise sources of hum, following the method of Ardhuin et al. (2011), in order to use the global seismic network for the validation of FIGW energy levels.

  10. Analysis and numerical modeling of the global free infra-gravity wave climate for the SWOT mission

    NASA Astrophysics Data System (ADS)

    Ardhuin, Fabrice; Aucan, Jérome; Rawat, Arshad

    2013-04-01

    uses the energy balance equation, used for large scale models of swells and wind-waves, extended to periods of 100 s. The source of FIGWs energy is treated like coastal reflection (Ardhuin and Roland 2012). The amount of FIGW energy at the shoreline is crudely represented as a constant fraction of the incoming bound wave energy. The spatial and temporal variability of the modeled FIGW energy is similar to that in data from DART stations. Future work will include an estimation of seismic noise sources of hum, following the method of Ardhuin et al. (2011), in order to use the global seismic network for the validation of FIGW energy levels.

  11. Responsiveness and minimal clinically important difference for pain and disability instruments in low back pain patients

    PubMed Central

    Lauridsen, Henrik H; Hartvigsen, Jan; Manniche, Claus; Korsholm, Lars; Grunnet-Nilsson, Niels

    2006-01-01

    Background The choice of an evaluative instrument has been hampered by the lack of head-to-head comparisons of responsiveness and the minimal clinically important difference (MCID) in subpopulations of low back pain (LBP). The objective of this study was to concurrently compare responsiveness and MCID for commonly used pain scales and functional instruments in four subpopulations of LBP patients. Methods The Danish versions of the Oswestry Disability Index (ODI), the 23-item Roland Morris Disability Questionnaire (RMQ), the physical function and bodily pain subscales of the SF36, the Low Back Pain Rating Scale (LBPRS) and a numerical rating scale for pain (0–10) were completed by 191 patients from the primary and secondary sectors of the Danish health care system. Clinical change was estimated using a 7-point transition question and a numeric rating scale for importance. Responsiveness was operationalised using standardardised response mean (SRM), area under the receiver operating characteristic curve (ROC), and cut-point analysis. Subpopulation analyses were carried out on primary and secondary sector patients with LBP only or leg pain +/- LBP. Results RMQ was the most responsive instrument in primary and secondary sector patients with LBP only (SRM = 0.5–1.4; ROC = 0.75–0.94) whereas ODI and RMQ showed almost similar responsiveness in primary and secondary sector patients with leg pain (ODI: SRM = 0.4–0.9; ROC = 0.76–0.89; RMQ: SRM = 0.3–0.9; ROC = 0.72–0.88). In improved patients, the RMQ was more responsive in primary and secondary sector patients and LBP only patients (SRM = 1.3–1.7) while the RMQ and ODI were equally responsive in leg pain patients (SRM = 1.3 and 1.2 respectively). All pain measures demonstrated almost equal responsiveness. The MCID increased with increasing baseline score in primary sector and LBP only patients but was only marginally affected by patient entry point and pain location. The MCID of the percentage change score

  12. Non-specific mechanisms in orthodox and CAM management of low back pain (MOCAM): theoretical framework and protocol for a prospective cohort study

    PubMed Central

    Bradbury, Katherine; Al-Abbadey, Miznah; Carnes, Dawn; Dimitrov, Borislav D; Eardley, Susan; Fawkes, Carol; Foster, Jo; Greville-Harris, Maddy; Harvey, J Matthew; Leach, Janine; Lewith, George; Roberts, Lisa; Parry, Laura; Yardley, Lucy; Bishop, Felicity L

    2016-01-01

    Introduction Components other than the active ingredients of treatment can have substantial effects on pain and disability. Such ‘non-specific’ components include: the therapeutic relationship, the healthcare environment, incidental treatment characteristics, patients’ beliefs and practitioners’ beliefs. This study aims to: identify the most powerful non-specific treatment components for low back pain (LBP), compare their effects on patient outcomes across orthodox (physiotherapy) and complementary (osteopathy, acupuncture) therapies, test which theoretically derived mechanistic pathways explain the effects of non-specific components and identify similarities and differences between the therapies on patient–practitioner interactions. Methods and analysis This research comprises a prospective questionnaire-based cohort study with a nested mixed-methods study. A minimum of 144 practitioners will be recruited from public and private sector settings (48 physiotherapists, 48 osteopaths and 48 acupuncturists). Practitioners are asked to recruit 10–30 patients each, by handing out invitation packs to adult patients presenting with a new episode of LBP. The planned multilevel analysis requires a final sample size of 690 patients to detect correlations between predictors, hypothesised mediators and the primary outcome (self-reported back-related disability on the Roland-Morris Disability Questionnaire). Practitioners and patients complete questionnaires measuring non-specific treatment components, mediators and outcomes at: baseline (time 1: after the first consultation for a new episode of LBP), during treatment (time 2: 2 weeks post-baseline) and short-term outcome (time 3: 3 months post-baseline). A randomly selected subsample of participants in the questionnaire study will be invited to take part in a nested mixed-methods study of patient–practitioner interactions. In the nested study, 63 consultations (21/therapy) will be audio-recorded and analysed

  13. An Innovative and Portable Multimodal Pain Relief Device for the Management of Neuropathic Low Back Pain - a Study from Kashmir (Southeast Asia)

    PubMed Central

    Lone, Baseer-ul-Rasool; Beigh, Mirza-Idrees-ul-Haq; Manzoor, Mushbiq

    2016-01-01

    We developed a portable multimodal system with seven different mechanisms of pain relief incorporated into a lumbar belt called the Comfort-N-Harmony Belt (C&H belt). Here, we describe the technical details of the system and also summarize the effects of this multimodal pain relieving technology as an adjuvant to analgesics versus analgesics alone, on the level of pain, improvement of psychological status, disability, and the quality of life in the patients with neuropathic low back pain (LBP). We tracked the volunteers who were following up at a tertiary health care center for the complaints of neuropathic LBP of minimum three months duration and were on analgesics alone with no relief in the severity of the pain. Study group A (n = 45) consisted of volunteers with LBP on C&H belt therapy, along with the usually prescribed analgesic intake, and group B (n = 45) with LBP volunteers on analgesics, plus a similar looking but plain leather belt (placebo). For pain, the VAS (Visual Analogue Scale); for anxiety and depression, the (HADS) Hospital Anxiety-Depression Scale; for disability, the RMDQ (Roland Morris Disability Questionnaire); and for quality of life, (NHP) Nottingham-Health-Profile were used before and after the study period.  There were no significant differences in demographic variables between the groups (p < 0.05). After the study period of one month, VAS, RMDQ, NHP-pain, NHP-physical activity, and HADS scores in both groups were significantly improved compared to the pre-treatment scores (p < 0.05). Group A also showed significant improvements in the scores of NHP-energy level and NHP-social isolation (p < 0.05). The post-treatment scores did not significantly show any difference between the two groups (p > 0.05). However, in comparison of pre- and post-treatment scores, the pre-treatment score values of RMDQ, NHP-pain, NHP-physical activity, and NHP-social isolation were much higher in group A compared to the group B, but still these scores were

  14. Tactile acuity training for patients with chronic low back pain: a pilot randomised controlled trial

    PubMed Central

    2014-01-01

    Background Chronic pain can disrupt the cortical representation of a painful body part. This disruption may play a role in maintaining the individual’s pain. Tactile acuity training has been used to normalise cortical representation and reduce pain in certain pain conditions. However, there is little evidence for the effectiveness of this intervention for chronic low back pain (CLBP). The primary aim of this study was to inform the development of a fully powered randomised controlled trial (RCT) by providing preliminary data on the effect of tactile acuity training on pain and function in individuals with CLBP. The secondary aim was to obtain qualitative feedback about the intervention. Methods In this mixed-methods pilot RCT 15 individuals were randomised to either an intervention (tactile acuity training) or a placebo group (sham tactile acuity training). All participants received 3 sessions of acuity training (intervention or sham) from a physiotherapist and were requested to undertake daily acuity home training facilitated by an informal carer (friend/relative). All participants also received usual care physiotherapy. The primary outcome measures were pain (0-100visual analogue scale (VAS)) and function (Roland Morris Disability Questionnaire (RMDQ)). Participants and their informal carers were invited to a focus group to provide feedback on the intervention. Results The placebo group improved by the greatest magnitude for both outcome measures, but there was no statistically significant difference (Mean difference (95%CI), p-value) between groups for change in pain (25.6 (-0.7 to 51.9), p = 0.056) or function (2.2 (-1.6 to 6.0), p = 0.237). Comparing the number of individuals achieving a minimally clinically significant improvement, the placebo group had better outcomes for pain with all participants achieving ≥30% improvement compared to only a third of the intervention group (6/6 vs. 3/9, p = 0.036). Qualitatively, participants reported that

  15. Identifying environmental sounds: a multimodal mapping study

    PubMed Central

    Tomasino, Barbara; Canderan, Cinzia; Marin, Dario; Maieron, Marta; Gremese, Michele; D'Agostini, Serena; Fabbro, Franco; Skrap, Miran

    2015-01-01

    Our environment is full of auditory events such as warnings or hazards, and their correct recognition is essential. We explored environmental sounds (ES) recognition in a series of studies. In study 1 we performed an Activation Likelihood Estimation (ALE) meta-analysis of neuroimaging experiments addressing ES processing to delineate the network of areas consistently involved in ES processing. Areas consistently activated in the ALE meta-analysis were the STG/MTG, insula/rolandic operculum, parahippocampal gyrus and inferior frontal gyrus bilaterally. Some of these areas truly reflect ES processing, whereas others are related to design choices, e.g., type of task, type of control condition, type of stimulus. In study 2 we report on 7 neurosurgical patients with lesions involving the areas which were found to be activated by the ALE meta-analysis. We tested their ES recognition abilities and found an impairment of ES recognition. These results indicate that deficits of ES recognition do not exclusively reflect lesions to the right or to the left hemisphere but both hemispheres are involved. The most frequently lesioned area is the hippocampus/insula/STG. We made sure that any impairment in ES recognition would not be related to language problems, but reflect impaired ES processing. In study 3 we carried out an fMRI study on patients (vs. healthy controls) to investigate how the areas involved in ES might be functionally deregulated because of a lesion. The fMRI evidenced that controls activated the right IFG, the STG bilaterally and the left insula. We applied a multimodal mapping approach and found that, although the meta-analysis showed that part of the left and right STG/MTG activation during ES processing might in part be related to design choices, this area was one of the most frequently lesioned areas in our patients, thus highlighting its causal role in ES processing. We found that the ROIs we drew on the two clusters of activation found in the left and in

  16. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, P.; Partnership, Emso

    2009-04-01

    EMSO, a Research Infrastructure listed within ESFRI (European Strategy Forum on Research Infrastructures) Roadmap), is the European-scale network of multidisciplinary seafloor observatories from the Arctic to the Black Sea with the scientific objective of long-term real-time monitoring of processes related to geosphere/biosphere/hydrosphere interactions. EMSO will enhance our understanding of processes through long time series appropriate to the scale of the phenomena, constituting the new frontier of studying Earth interior, deep-sea biology and chemistry and ocean processes. EMSO will reply also to the need expressed in the frame of GMES (Global Monitoring for Environment and Security) to develop a marine segment integrated in the in situ and satellite global monitoring system. The EMSO development relays upon the synergy between the scientific community and the industry to improve the European competitiveness with respect to countries like USA/Canada, NEPTUNE, VENUS and MARS projects, Taiwan, MACHO project, and Japan, DONET project. In Europe the development of an underwater network is based on previous EU-funded projects since early '90, and presently supported by EU initiatives. The EMSO infrastructure will constitute the extension to the sea of the land-based networks. Examples of data recorded by seafloor observatories will be presented. EMSO is presently at the stage of Preparatory Phase (PP), funded in the EC FP7 Capacities Programme. The project has started in April 2008 and will last 4 years with the participation of 12 Institutions representing 12 countries. EMSO potential will be significantly increased also with the interaction with other Research Infrastructures addressed to Earth Science. 2. IFREMER-Institut Français de Recherche pour l'exploitation de la mer (France, ref. Roland Person); KDM-Konsortium Deutsche Meeresforschung e.V. (Germany, ref. Christoph Waldmann); IMI-Irish Marine Institute (Ireland, ref. Michael Gillooly); UTM-CSIC-Unidad de

  17. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, Paolo

    2010-05-01

    EMSO, a Research Infrastructure listed within ESFRI (European Strategy Forum on Research Infrastructures) Roadmap (Report 2006, http://cordis.europa.eu/esfri/roadmap.htm), is the European-scale network of multidisciplinary seafloor observatories from the Arctic to the Black Sea with the scientific objective of long-term real-time monitoring of processes related to geosphere/biosphere/hydrosphere interactions. EMSO will enhance our understanding of processes through long time series appropriate to the scale of the phenomena, constituting the new frontier of studying Earth interior, deep-sea biology and chemistry and ocean processes. The development of an underwater network is based on previous EU-funded projects since early '90 and is being supported by several EU initiatives, as the on-going ESONET-NoE, coordinated by IFREMER (2007-2011, http://www.esonet-emso.org/esonet-noe/), and aims at gathering together the Research Community of the Ocean Observatories. In 2006 the FP7 Capacities Programme launched a call for Preparatory Phase (PP) projects, that will provide the support to create the legal and organisational entities in charge of managing the infrastructures, and coordinating the financial effort among the countries. Under this call the EMSO-PP project was approved in 2007 with the coordination of INGV and the participation of other 11 Institutions of 11 countries. The project has started in April 2008 and will last 4 years. The EMSO is a key-infrastructure both for Ocean Sciences and for Solid Earth Sciences. In this respect it will enhance and complement profitably the capabilities of other European research infrastructures such as EPOS, ERICON-Aurora Borealis, and SIOS. The perspective of the synergy among EMSO and other ESFRI Research Infrastructures will be outlined. EMSO Partners: IFREMER-Institut Français de Recherche pour l'exploitation de la mer (France, ref. Roland Person); KDM-Konsortium Deutsche Meeresforschung e.V. (Germany, ref. Christoph

  18. Tabulation of comet observations.

    NASA Astrophysics Data System (ADS)

    1991-07-01

    Concerning comets: 1957 III Arend-Roland, 1957 V Mrkos, 1958 III Burnham, 1959 III Bester-Hoffmeister, 1959 VI Alcock, 1959 VIII P/Giacobini-Zinner, 1960 I P/Wild 1, 1960 II Burnham, 1960 III P/Schaumasse, 1960 VIII P/Finlay, 1961 V Wilson-Hubbard, 1961 VIII Seki, 1962 III Seki-Lines, 1962 VIII Humason, 1963 I Ikeya, 1963 III Alcock, 1963 V Pereyra, 1964 VI Tomita-Gerber-Honda, 1964 VIII Ikeya, 1964 IX Everhart, 1979 X Bradfield, 1980 X P/Stephan-Oterma, 1980 XII Meier, 1980 XIII P/Tuttle, 1981 II Panther, 1982 I Bowell, 1982 IV P/Grigg-Skjellerup, 1982 VII P/d'Arrest, 1986 III P/Halley, 1987 IV Shoemaker, 1987 XII P/Hartley 3, 1987 XIX P/Schwassmann-Wachmann 2, 1987 XXIX Bradfield, 1987 XXX Levy, 1987 XXXII McNaught, 1987 XXXIII P/Borrelly, 1987 XXXVI P/Parker-Hartley, 1987 XXXVII P/Helin- Roman-Alu 1, 1988 III Shoemaker-Holt, 1988 V Liller, 1988 VIII P/Ge-Wang, 1988 XI P/Shoemaker-Holt 2, 1988 XIV P/Tempel 2, 1988 XV Machholz, 1988 XX Yanaka, 1988 XXI Shoemaker, 1988 XXIV Yanaka, 1989 III Shoemaker, 1989 V Shoemaker-Holt-Rodriquez, 1989 VIII P/Pons-Winnecke, 1989 X P/Brorsen-Metcalf, 1989 XI P/Gunn, 1989 XIII P/Lovas 1, 1989 XVIII McKenzie-Russell, 1989 XIX Okazaki-Levy-Rudenko, 1989 XX P/Clark, 1989 XXI Helin-Ronan-Alu, 1989 XXII Aarseth-Brewington, 1989h P/Van Biesbroeck, 1989t P/Wild 2, 1989u P/Kearns-Kwee, 1989c1 Austin, 1989e1 Skorichenko-George, 1990a P/Wild 4, 1990b Černis-Kiuchi-Nakamura, 1990c Levy, 1990e P/Wolf-Harrington, 1990f P/Honda-Mrkos-Pajdušáková, 1990g McNaught-Hughes, 1990i Tsuchiya-Kiuchi, 1990n P/Taylor, 1990ο P/Shoemaker-Levy 1, 1991a P/Metcalf-Brewington, 1991b Arai, 1991c P/Swift-Gehrels, 1991d Shoemaker-Levy, 1991e P/Shoemaker-Levy 3, 1991h P/Takamizawa, 1991j P/Hartley 1, 1991k P/Mrkos, 1991l Helin-Lawrence, 1991n P/Faye, 1991q P/Levy, 1991t P/Hartley 2, P/Encke, P/Schwassmann-Wachmann 1.

  19. The long-term fate of permafrost peatlands under rapid climate warming

    NASA Astrophysics Data System (ADS)

    Swindles, Graeme T.; Morris, Paul J.

    2016-04-01

    High-latitude permafrost peatlands contain globally important amounts of soil organic carbon, owing to cold conditions which suppress anaerobic decomposition. However, there is much concern that climate warming and subsequent permafrost thaw threaten the stability of this carbon store. The ultimate fate of permafrost peatlands and their carbon stores is unclear because of complex feedbacks between peat accumulation, hydrology and vegetation. Unfortunately, field monitoring campaigns only span the last few decades and therefore provide an incomplete picture of permafrost peatland response to rapid warming in the twentieth century. Here we use a high-resolution palaeoecological approach to understand the longer-term response of peatlands in Subarctic Sweden in contrasting states of permafrost degradation to recent rapid warming. At all sites we identify a drying trend until the late-twentieth century; however, two sites subsequently experienced a rapid shift to wetter conditions as permafrost thawed in response to climatic warming, culminating in collapse of the peat domes. Commonalities between study sites lead us to propose a five-phase model for permafrost peatland response to climatic warming. This model suggests a shared ecohydrological trajectory towards a common end point: inundated Arctic fen. Although carbon accumulation is rapid in such sites, and thus peatland ecosystem services are resumed, saturated soil conditions are likely to cause elevated methane emissions that have implications for climate-feedback mechanisms. We outline our plans to test the model published in Swindles et al. (2015) using the same methodological approach in other high-latitude locations, including zones of continuous and discontinuous permafrost. Reference: Swindles, G.T., Morris, P.J., Mullan, D., Watson, E.J., Turner, T.E., Roland, T., Amesbury, M.J., Kokfelt, U., Schoning, K., Pratte, S., Gallego-Sala, A., Charman, D.J., Sanderson, N., Garneau, M., Carrivick, J.L., Woulds, C

  20. Preface: phys. stat. sol. (b) 242/2

    NASA Astrophysics Data System (ADS)

    Szopa, Marek; Mierzejewski, Marcin; Lisowski, Mariusz

    2005-02-01

    This issue contains the Proceedings of the 28th International Conference of Theoretical Physics, ICTP2004 - Electron Correlations in Nano- and Macrosystems, which was held in Ustro, Poland, from 2-7 September 2004. ICTP2004 followed the series of conferences organized by the Institute of Physics of the University of Silesia in Katowice, devoted biannually to the physics of condensed matter.The main objective of the Conference was to bring together specialists working on the physics of electron correlations in nano- and macro-regimes, with the intention of enhancing their mutual understanding and cooperation. The Conference was an international forum for the presentation and discussion of novel scientific ideas and experimental results. The programme of the conference consisted of 25 invited lectures, 11 contributed lectures and 27 papers presented during poster session. The contributions were devoted to problems related to the following subjects: Transport in low dimensional systems Carbon nanotubes and fullerenes Non Fermi liquid systems Superconductivity and Magnetism Quantum phase transitions New materials in magnetoelectronics Among the participants were 88 scientists from 10 countries and 3 continents. The invited talks were presented by distinguished physicists: Hélène Bouchiat, Liviu Chibotaru, Ulrich Eckern, Klaus Ensslin, Jim Freericks, Raymond Frésard, Peter Hänggi, Heike Herper, Carsten Honerkamp, Helmut Keiter, Stefan Krompiewski, Tadeusz Lulek, Kazumi Maki, Nina Markovi, Roman Micnas, Volker Meden, Andrzej M. Ole, Thomas Pruschke, Marek Przybylski, Ken-ichi Sasaki, Uri Sivan, Józef Spaek, Frank Steglich, Michael Thorwart and Roland Zeyher. The Organizing Committee would like to express our gratitude to the International Scientific Committee and to all the speakers and contributors for their talks and posters. Special thanks are addressed to all the participants for their valuable discussions and stimulating atmosphere of the meeting. We express

  1. Ultrasound assessment of transversus abdominis muscle contraction ratio during abdominal hollowing: a useful tool to distinguish between patients with chronic low back pain and healthy controls?

    PubMed

    Pulkovski, N; Mannion, A F; Caporaso, F; Toma, V; Gubler, D; Helbling, D; Sprott, H

    2012-08-01

    Spine stabilisation exercises, in which patients are taught to preferentially activate the transversus abdominus (TrA) during "abdominal hollowing" (AH), are a popular treatment for chronic low back pain (cLBP). The present study investigated whether performance during AH differed between cLBP patients and controls to an extent that would render it useful diagnostic tool. 50 patients with cLBP (46.3 ± 12.5 years) and 50 healthy controls (43.6 ± 12.7 years) participated in this case-control study. They performed AH in hook-lying. Using M-mode ultrasound, thicknesses of TrA, and obliquus internus and externus were determined at rest and during 5 s AH (5 measures each body side). The TrA contraction-ratio (TrA-CR) (TrA contracted/rest) and the ability to sustain the contraction [standard deviation (SD) of TrA thickness during the stable phase of the hold] were investigated. There were no significant group differences for the absolute muscle thicknesses at rest or during AH, or for the SD of TrA thickness. There was a small but significant difference between the groups for TrA-CR: cLBP 1.35 ± 0.14, controls 1.44 ± 0.24 (p < 0.05). However, Receiver Operator Characteristics (ROC) analysis revealed a poor and non-significant ability of TrA-CR to discriminate between cLBP patients and controls on an individual basis (ROC area under the curve, 0.60 [95% CI 0.495; 0.695], p = 0.08). In the patient group, TrA-CR showed a low but significant correlation with Roland Morris score (Spearman Rho = 0.328; p = 0.02). In conclusion, the difference in group mean values for TrA-CR was small and of uncertain clinical relevance. Moreover, TrA-CR showed a poor ability to discriminate between control and cLBP subjects on an individual basis. We conclude that the TrA-CR during abdominal hollowing does not distinguish well between patients with chronic low back pain and healthy controls.

  2. A randomised controlled trial of post-operative rehabilitation after surgical decompression of the lumbar spine

    PubMed Central

    Denzler, Raymond; Dvorak, Jiri; Müntener, Markus; Grob, Dieter

    2007-01-01

    Spinal decompression is the most common type of spinal surgery carried out in the older patient, and is being performed with increasing frequency. Physiotherapy (rehabilitation) is often prescribed after surgery, although its benefits compared with no formal rehabilitation have yet to be demonstrated in randomised control trials. The aim of this randomised controlled trial was to examine the effects on outcome up to 2 years after spinal decompression surgery of two types of postoperative physiotherapy compared with no postoperative therapy (self-management). Hundred and fifty-nine patients (100 men, 59 women; 65 ± 11 years) undergoing decompression surgery for spinal stenosis/herniated disc were randomised to one of the following programmes beginning 2 months post-op: recommended to “keep active” (CONTROL; n = 54); physiotherapy, spine stabilisation exercises (PT-StabEx; n = 56); physiotherapy, mixed techniques (PT-Mixed; n = 49). Both PT programmes involved 2 × 30 min sessions/week for up to 12 weeks, with home exercises. Pain intensity (0–10 graphic rating scale, for back and leg pain separately) and self-rated disability (Roland Morris) were assessed before surgery, before and after the rehabilitation phase (approx. 2 and 5 months post-op), and at 12 and 24 months after the operation. ‘Intention to treat’ analyses were used. At 24 months, 151 patients returned questionnaires (effective return rate, excluding 4 deaths, 97%). Significant reductions in leg and back pain and self-rated disability were recorded after surgery (P < 0.05). Pain showed no further changes in any group up to 24 months later, whereas disability declined further during the “rehabilitation” phase (P < 0.05) then stabilised, but with no significant group differences. 12 weeks of post-operative physiotherapy did not influence the course of change in pain or disability up to 24 months after decompression surgery. Advising patients to keep active by

  3. Citations Prize 2013

    NASA Astrophysics Data System (ADS)

    Cherry, Simon; Ruffle, Jon

    2014-06-01

    Physics in Medicine and Biology (PMB) awards its 'Citations Prize' to the authors of the original research paper that has received the most citations in the preceding five years (according to the Institute for Scientific Information (ISI)). The lead author of the winning paper is presented with the Rotblat Medal (named in honour of Professor Sir Joseph Rotblat, a Nobel Prize winner who also was the second—and longest serving—Editor of PMB, from 1961-1972). The winner of the 2013 Citations Prize for the paper which has received the most citations in the previous five years (2008-2012) is Figure. Figure. Four of the prize winning authors. From left to right: Thomas Istel (Philips), Jens-Peter Schlomka (with medal, MorphoDetection), Ewald Roessl (Philips), and Gerhard Martens (Philips). Title: Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography Authors: Jens Peter Schlomka1, Ewald Roessl1, Ralf Dorscheid2, Stefan Dill2, Gerhard Martens1, Thomas Istel1, Christian Bäumer3, Christoph Herrmann3, Roger Steadman3, Günter Zeitler3, Amir Livne4 and Roland Proksa1 Institutions: 1 Philips Research Europe, Sector Medical Imaging Systems, Hamburg, Germany 2 Philips Research Europe, Engineering & Technology, Aachen, Germany 3 Philips Research Europe, Sector Medical Imaging Systems, Aachen, Germany 4 Philips Healthcare, Global Research and Advanced Development, Haifa, Israel Reference: Schlomka et al 2008 Phys. Med. Biol. 53 4031-47 This paper becomes the first to win both this citations prize and also the PMB best paper prize (The Roberts Prize), which it won for the year 2008. Discussion of the significance of the winning paper can be found in this medicalphysicsweb article from the time of the Roberts Prize win (http://medicalphysicsweb.org/cws/article/research/39907). The author's enthusiasm for their prototype spectral CT system has certainly been reflected in the large number of citations the paper subsequently has

  4. Comparison of complementary and alternative medicine with conventional mind–body therapies for chronic back pain: protocol for the Mind–body Approaches to Pain (MAP) randomized controlled trial

    PubMed Central

    2014-01-01

    Background The self-reported health and functional status of persons with back pain in the United States have declined in recent years, despite greatly increased medical expenditures due to this problem. Although patient psychosocial factors such as pain-related beliefs, thoughts and coping behaviors have been demonstrated to affect how well patients respond to treatments for back pain, few patients receive treatments that address these factors. Cognitive-behavioral therapy (CBT), which addresses psychosocial factors, has been found to be effective for back pain, but access to qualified therapists is limited. Another treatment option with potential for addressing psychosocial issues, mindfulness-based stress reduction (MBSR), is increasingly available. MBSR has been found to be helpful for various mental and physical conditions, but it has not been well-studied for application with chronic back pain patients. In this trial, we will seek to determine whether MBSR is an effective and cost-effective treatment option for persons with chronic back pain, compare its effectiveness and cost-effectiveness compared with CBT and explore the psychosocial variables that may mediate the effects of MBSR and CBT on patient outcomes. Methods/Design In this trial, we will randomize 397 adults with nonspecific chronic back pain to CBT, MBSR or usual care arms (99 per group). Both interventions will consist of eight weekly 2-hour group sessions supplemented by home practice. The MBSR protocol also includes an optional 6-hour retreat. Interviewers masked to treatment assignments will assess outcomes 5, 10, 26 and 52 weeks postrandomization. The primary outcomes will be pain-related functional limitations (based on the Roland Disability Questionnaire) and symptom bothersomeness (rated on a 0 to 10 numerical rating scale) at 26 weeks. Discussion If MBSR is found to be an effective and cost-effective treatment option for patients with chronic back pain, it will become a valuable

  5. Back pain outcomes in primary care following a practice improvement intervention:- a prospective cohort study

    PubMed Central

    2011-01-01

    Background Back pain is one of the UK's costliest and least understood health problems, whose prevalence still seems to be increasing. Educational interventions for general practitioners on back pain appear to have had little impact on practice, but these did not include quality improvement learning, involve patients in the learning, record costs or document practice activities as well as patient outcomes. Methods We assessed the outcome of providing information about quality improvement techniques and evidence-based practice for back pain using the Clinical Value Compass. This included clinical outcomes (Roland and Morris Disability Questionnaire), functional outcomes, costs of care and patient satisfaction. We provided workshops which used an action learning approach and collected before and after data on routine practice activity from practice electronic databases. In parallel, we studied outcomes in a separate cohort of patients with acute and sub-acute non-specific back pain recruited from the same practices over the same time period. Patient data were analysed as a prospective, split-cohort study with assessments at baseline and eight weeks following the first consultation. Results Data for 1014 patients were recorded in the practice database study, and 101 patients in the prospective cohort study. We found that practice activities, costs and patient outcomes changed little after the intervention. However, the intervention was associated with a small, but statistically significant reduction in disability in female patients. Additionally, baseline disability, downheartedness, self-rated health and leg pain had small but statistically significant effects (p < 0.05) on follow-up disability scores in some subgroups. Conclusions GP education for back pain that both includes health improvement methodologies and involves patients may yield additional benefits for some patients without large changes in patterns of practice activity. The effects in this study were

  6. PEGASUS - An Austrian Nanosatellite for QB50

    NASA Astrophysics Data System (ADS)

    Scharlemann, Carsten; Seifert, Bernhard; Kohl, Dominik; Birschitzky, David; Gury, Lionel; Kerschbaum, Franz; Obertscheider, Christof; Ottensamer, Roland; Reissner, Alexander; Riel, Thomas; Sypniewski, Richard; Taraba, Michael; Trausmuth, Robert; Turetschek, Thomas

    2015-04-01

    PEGASUS - An Austrian Nanosatellite for QB50 C. Scharlemann* David Birschitzky* Lionel Gury*, Franz Kerschbaum~, Dominik Kohl#, Christof Obertscheider*, Roland Ottensamer~, Alexander Reissner+, Thomas Riel#, B. Seifert+, Richard Sypniewski*, Michael Taraba?, Robert Trausmuth*, Thomas Turetschek?, …. (*)University of Applied Sciences Wiener Neustadt, Austria (+)FOTEC GmbH, Wiener Neustadt, Austria (+) Spaceteam, TU Wien, Austria (~) University Wien, Wien, Austria The QB50 project is an international project with the goal to send up to 50 Nanosatellites, a.k.a. CubeSat, into the Thermosphere. The scientific goal of this mission is to monitor over a period of up to nine months the prevailing conditions in this rather unknown part of Earth's atmosphere. Each of the 50 nanosatellites will be equipped with one of three possible scientific instruments: (i) a set of Langmuir probes, (ii) atomic oxygen measurement device, (iii) ion/neutral mass spectrometer. All satellites will be launched together and released in a string-of-pearls type fashion. It is predicted that the satellites will drift apart rather rapidly following the release. Therefore, the QB50 missions offers the possibility of a measurement grid in the thermosphere of unprecedented scope and accuracy. One of the satellites, named PEGASUS, is designed and build by a team of Austrian researches and students. PEGASUS will be equipped with the aforementioned Langmuir probes and will provide information about essential properties of the plasma in the thermosphere such as the electrontemperature and -density. In order to ensure the capability to collect and downlink the data over several months, PEGASUS requires about the same types of subsystems as one would find on large-scale satellites. This includes an attitude control system, an on-board computer, telecommunication devices, an electrical power systems allowing to harvest the solar power and either distribute or store it for later use, a thermal control system

  7. Prevention of low back pain: effect, cost-effectiveness, and cost-utility of maintenance care – study protocol for a randomized clinical trial

    PubMed Central

    2014-01-01

    Background Low back pain (LBP) is a prevalent condition and a socioeconomic problem in many countries. Due to its recurrent nature, the prevention of further episodes (secondary prevention), seems logical. Furthermore, when the condition is persistent, the minimization of symptoms and prevention of deterioration (tertiary prevention), is equally important. Research has largely focused on treatment methods for symptomatic episodes, and little is known about preventive treatment strategies. Methods/Design This study protocol describes a randomized controlled clinical trial in a multicenter setting investigating the effect and cost-effectiveness of preventive manual care (chiropractic maintenance care) in a population of patients with recurrent or persistent LBP. Four hundred consecutive study subjects with recurrent or persistent LBP will be recruited from chiropractic clinics in Sweden. The primary outcome is the number of days with bothersome pain over 12 months. Secondary measures are self-rated health (EQ-5D), function (the Roland Morris Disability Questionnaire), psychological profile (the Multidimensional Pain Inventory), pain intensity (the Numeric Rating Scale), and work absence. The primary utility measure of the study is quality-adjusted life years and will be calculated using the EQ-5D questionnaire. Direct medical costs as well as indirect costs will be considered. Subjects are randomly allocated into two treatment arms: 1) Symptom-guided treatment (patient controlled), receiving care when patients feel a need. 2) Preventive treatment (clinician controlled), receiving care on a regular basis. Eligibility screening takes place in two phases: first, when assessing the primary inclusion/exclusion criteria, and then to only include fast responders, i.e., subjects who respond well to initial treatment. Data are collected at baseline and at follow-up as well as weekly, using SMS text messages. Discussion This study investigates a manual strategy (chiropractic

  8. Participant Characteristics Associated with Symptomatic Improvement from Yoga for Chronic Low Back Pain

    PubMed Central

    Stein, Kim M; Weinberg, Janice; Sherman, Karen J; Lemaster, Chelsey M; Saper, Robert

    2014-01-01

    Context Studies suggest that yoga is effective for moderate to severe chronic low back pain (cLBP) in diverse predominantly lower socioeconomic status populations. However, little is known about factors associated with benefit from the yoga intervention. Objective Identify factors at baseline independently associated with greater efficacy among participants in a study of yoga for cLBP. Design From September–December 2011, a 12-week randomized dosing trial was conducted comparing weekly vs. twice-weekly 75-minute hatha yoga classes for 95 predominantly low-income minority adults with nonspecific cLBP. Participant characteristics collected at baseline were used to determine factors beyond treatment assignment (reported in the initial study) that predicted outcome. We used bivariate testing to identify baseline characteristics associated with improvement in function and pain, and included select factors in a multivariate linear regression. Setting Recruitment and classes occurred in an academic safety-net hospital and five affiliated community health centers in Boston, Massachusetts. Participants Ninety-five adults with nonspecific cLBP, ages ranging from 20–64 (mean 48) years; 72 women and 23 men. Outcome measures Primary outcomes were changes in back-related function (modified Roland-Morris Disability Questionnaire, RMDQ; 0–23) and mean low back pain intensity (0–10) in the previous week, from baseline to week 12. Results Adjusting for group assignment, baseline RMDQ, age, and gender, foreign nationality and lower baseline SF36 physical component score (PCS) were independently associated with improvement in RMDQ. Greater than high school education level, cLBP less than 1 year, and lower baseline SF36 PCS were independently associated with improvement in pain intensity. Other demographics including race, income, gender, BMI, and use of pain medications were not associated with either outcome. Conclusions Poor physical health at baseline is associated with

  9. A Model of Integrative Care for Low-Back Pain

    PubMed Central

    Buring, Julie E.; Hrbek, Andrea L.; Davis, Roger B.; Connelly, Maureen T.; Cherkin, Daniel C.; Levy, Donald B.; Cunningham, Mark; O'Connor, Bonnie; Post, Diana E.

    2012-01-01

    Abstract Objectives While previous studies focused on the effectiveness of individual complementary and alternative medical (CAM) therapies, the value of providing patients access to an integrated program involving multiple CAM and conventional therapies remains unknown. The objective of this study is to explore the feasibility and effects of a model of multidisciplinary integrative care for subacute low-back pain (LBP) in an academic teaching hospital. Design This was a pilot randomized trial comparing an individualized program of integrative care (IC) plus usual care to usual care (UC) alone for adults with LBP. Subjects Twenty (20) individuals with LPB of 3–12 weeks' duration were recruited from an occupational health clinic and community health center. Interventions Participants were randomized to 12 weeks of individualized IC plus usual care versus UC alone. IC was provided by a trained multidisciplinary team offering CAM therapies and conventional medical care. Outcome measures The outcome measures were symptoms (pain, bothersomeness), functional status (Roland-Morris score), SF-12, worry, and difficulty performing three self-selected activities. Results Over 12 weeks, participants in the IC group had a median of 12.0 visits (range 5–25). IC participants experienced significantly greater improvements at 12 weeks than those receiving UC alone in symptom bothersomeness (p=0.02) and pain (p=0.005), and showed greater improvement in functional status (p=0.08). Rates of improvement were greater for patients in IC than UC in functional status (p=0.02), bothersomeness (p=0.002), and pain scores (p=0.001). Secondary outcomes of self-selected most challenging activity, worry, and the SF-12 also showed improvement in the IC group at 12 weeks. These differences persisted at 26 weeks, but were no longer statistically significant. Conclusions It was feasible for a multidisciplinary, outpatient IC team to deliver coordinated, individualized intervention to patients

  10. Map and Data for Quaternary Faults and Fault Systems on the Island of Hawai`i

    USGS Publications Warehouse

    Cannon, Eric C.; Burgmann, Roland; Crone, Anthony J.; Machette, Michael N.; Dart, Richard L.

    2007-01-01

    and catalog of data, both in Adobe Acrobat PDF format. The senior authors (Eric C. Cannon and Roland Burgmann) compiled the fault data as part of ongoing studies of active faulting on the Island of Hawai`i. The USGS is responsible for organizing and integrating the State or regional products under their National Seismic Hazard Mapping project, including the coordination and oversight of contributions from individuals and groups (Michael N. Machette and Anthony J. Crone), database design and management (Kathleen M. Haller), and digitization and analysis of map data (Richard L. Dart). After being released an Open-File Report, the data in this report will be available online at http://earthquake.usgs.gov/regional/qfaults/, the USGS Quaternary Fault and Fold Database of the United States.

  11. A Comparison of the Effects of 2 Types of Massage and Usual Care on Chronic Low Back Pain: A Randomized, Controlled Trial

    PubMed Central

    Cherkin, Daniel C.; Sherman, Karen J.; Kahn, Janet; Wellman, Robert; Cook, Andrea J.; Johnson, Eric; Erro, Janet; Delaney, Kristin; Deyo, Richard A.

    2013-01-01

    Background Few studies have evaluated the effectiveness of massage for back pain. Objective To evaluate the effectiveness of two types of massage for chronic back pain. Design Single-blind parallel group randomized controlled trial. Setting Integrated health care delivery system in Seattle area. Patients 401 persons 20 to 65 years of age with non-specific chronic low back pain. Interventions Ten treatments over 10 weeks of Structural Massage (intended to identify and alleviate musculoskeletal contributors to pain through focused soft-tissue manipulation) (n=132) or Relaxation Massage (intended to decrease pain and dysfunction by inducing relaxation) (n=136). Treatments provided by 27 experienced licensed massage therapists. Comparison group received continued usual care (n=133). Study presented as comparison of usual care with two types of massage. Measurements Primary outcomes were the Roland Disability Questionnaire (RDQ) and the Symptom Bothersomeness scale measured at 10 weeks. Outcomes also measured after 26 and 52 weeks. Results At 10 weeks, the massage groups had similar functional outcomes that were superior to those for usual care. The adjusted mean RDQ scores were 2.9 and 2.4 points lower for the relaxation and structural massage groups, respectively, compared to usual care (95% CIs: [1.8, 4.0] and [1.4, 3.5]). Adjusted mean symptom bothersomeness scores were 1.7 points and 1.4 points lower with relaxation and structural massage, respectively, versus usual care (95% CIs: [1.2, 2.2] and [0.8, 1.9]). The beneficial effects of relaxation massage on function (but not on symptom reduction) persisted at 52 weeks, but were small. Limitations Restricted to single site; therapists and patients not blinded to treatment. Conclusions This study confirms the results of smaller trials that massage is an effective treatment for chronic back pain with benefits lasting at least 6 months, and also finds no evidence of a clinically-meaningful difference in the effectiveness

  12. Validation of the baseline severity stratification of objective functional impairment in lumbar degenerative disc disease.

    PubMed

    Stienen, Martin N; Smoll, Nicolas R; Joswig, Holger; Corniola, Marco V; Schaller, Karl; Hildebrandt, Gerhard; Gautschi, Oliver P

    2017-03-03

    OBJECTIVE The Timed Up and Go (TUG) test is a simple, objective, and standardized method to measure objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). The objective of the current work was to validate the OFI baseline severity stratification (BSS; with levels of "none," "mild," "moderate," and "severe"). METHODS Data were collected in a prospective IRB-approved 2-center study. Patients were assessed with a comprehensive panel of scales for measuring pain (visual analog scale [VAS] for back and leg pain), functional impairment (Roland-Morris Disability Index [RMDI] and Oswestry Disability Index [ODI]), and health-related quality of life (HRQOL; EQ-5D and SF-12). OFI BSS was determined using age- and sex-adjusted cutoff values. RESULTS A total of 375 consecutive patients scheduled for lumbar spine surgery were included. Each 1-step increase on the OFI BSS corresponded to an increase of 0.53 in the back pain VAS score, 0.69 in the leg pain VAS score, 1.81 points in the RMDI, and 5.93 points in the ODI, as well as to a decrease in HRQOL of -0.073 in the EQ-5D, -1.99 in the SF-12 physical component summary (PCS), and -1.62 in the SF-12 mental component summary (MCS; all p < 0.001). Patients with mild, moderate, and severe OFI had increased leg pain by 0.90 (p = 0.044), 1.54 (p < 0.001), and 1.94 (p < 0.001); increased ODI by 7.99 (p = 0.004), 12.64 (p < 0.001), and 17.13 (p < 0.001); and decreased SF-12 PCS by -2.57 (p = 0.049), -3.63 (p = 0.003), and -6.23 (p < 0.001), respectively. CONCLUSIONS The OFI BSS is a valid measure of functional impairment for use in daily clinical practice. The presence of OFI indicates the presence of significant functional impairment on subjective outcome measures.

  13. List of Organizing Committees and Sponsors

    NASA Astrophysics Data System (ADS)

    2012-03-01

    Organizers DIRECTORS Maria L CalvoPresident of International Commission for Optics, Spain Aram V PapoyanDirector of Institute for Physical Research of NAS, Armenia HEADS OF PROJECT Tigran Dadalyan YSU, Armenia Artsrun MartirosyanIPR, Armenia COORDINATOR Narine GevorgyanIPR, Armenia / ICTP, Italy MANAGERS Paytsar MantashyanIPR, Armenia Karen VardanyanIPR, Armenia INTERNATIONAL ADVISORY COMMITTEE Marcis AuzinshLatvia Roland AvagyanArmenia Tapash ChakrabortyCanada Yuri ChilingaryanArmenia Eduard KazaryanArmenia Albert KirakosyanArmenia Radik KostanyanArmenia Avinash PandeyIndia Marat SoskinUkraine INTERNATIONAL PROGRAM COMMITTEE David Sarkisyan (Chair)Armenia Roman AlaverdyanArmenia Dan ApostolRomania Levon AslanyanArmenia Aranya BhattacherjeeIndia Gagik BuniatyanArmenia Vigen ChaltykyanArmenia Roldao Da RochaBrazil Miltcho DanailovItaly Vladimir GerdtRussia Samvel GevorgyanArmenia Gayane GrigoryanArmenia Rafik HakobyanArmenia Takayuki MiyaderaJapan Levon MouradianArmenia Atom MuradyanArmenia Simon RochesterUSA Hayk SarkisyanArmenia Aleksandr VardanyanArmenia LOCAL ORGANIZING COMMITTEE Narek AghekyanArmenia Anahit GogyanArmenia Melanya GrigoryanArmenia Armen HovhannisyanArmenia Lilit HovhannisyanArmenia Tatevik KhachatryanArmenia Astghik KuzanyanArmenia Satenik KuzanyanArmenia Vladimir LazarevRussia Lilit MantashyanArmenia Hripsime MkrtchyanArmenia Pavel MuzhikyanArmenia Wahi NarsisianArmenia Sahak OrdukhanyanArmenia Anna ReymersArmenia Narine TorosyanArmenia The Symposium was organized by YSU & NAS SPIE Armenian Student Chapter Institute for Physical Research (IPR) of National Academy of Sciences (NAS) Russian-Armenian (Slavonic) University (RAU) LT-PYRKAL cjsc Yerevan State University (YSU) Official Sponsors of the Symposium LT-PYRKAlRussian ArmenianSPIE LT-PYRKAL cjscRussian-Armenian UniversityYSU & NAS SPIE Student Chapter Further sponsors NFSATICTPSCSADevout Generation National Foundation of Science and Advanced TechnologiesThe Abdus Salam International Centre

  14. Efficacy and safety of acupuncture for the treatment of non-specific acute low back pain: a randomised controlled multicentre trial protocol [ISRCTN65814467

    PubMed Central

    Vas, Jorge; Perea-Milla, Emilio; Mendez, Camila; Silva, Luis Carlos; Herrera Galante, Antonia; Aranda Regules, Jose Manuel; Martinez Barquin, Dulce M; Aguilar, Inmaculada; Faus, Vicente

    2006-01-01

    Background Low back pain and its associated incapacitating effects constitute an important healthcare and socioeconomic problem, as well as being one of the main causes of disability among adults of working age. The prevalence of non-specific low back pain is very high among the general population, and 60–70% of adults are believed to have suffered this problem at some time. Nevertheless, few randomised clinical trials have been made of the efficacy and efficiency of acupuncture with respect to acute low back pain. The present study is intended to assess the efficacy of acupuncture for acute low back pain in terms of the improvement reported on the Roland Morris Questionnaire (RMQ) on low back pain incapacity, to estimate the specific and non-specific effects produced by the technique, and to carry out a cost-effectiveness analysis. Methods/Design Randomised four-branch controlled multicentre prospective study made to compare semi-standardised real acupuncture, sham acupuncture (acupuncture at non-specific points), placebo acupuncture and conventional treatment. The patients are blinded to the real, sham and placebo acupuncture treatments. Patients in the sample present symptoms of non specific acute low back pain, with a case history of 2 weeks or less, and will be selected from working-age patients, whether in paid employment or not, referred by General Practitioners from Primary Healthcare Clinics to the four clinics participating in this study. In order to assess the primary and secondary result measures, the patients will be requested to fill in a questionnaire before the randomisation and again at 3, 12 and 48 weeks after starting the treatment. The primary result measure will be the clinical relevant improvement (CRI) at 3 weeks after randomisation. We define CRI as a reduction of 35% or more in the RMQ results. Discussion This study is intended to obtain further evidence on the effectiveness of acupuncture on acute low back pain and to isolate the

  15. Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study

    PubMed Central

    Murase, Kimihiko; Tabara, Yasuharu; Ito, Hiromu; Kobayashi, Masahiko; Takahashi, Yoshimitsu; Setoh, Kazuya; Kawaguchi, Takahisa; Muro, Shigeo; Kadotani, Hiroshi; Kosugi, Shinji; Sekine, Akihiro; Yamada, Ryo; Nakayama, Takeo; Mishima, Michiaki; Matsuda, Shuichi; Matsuda, Fumihiko; Chin, Kazuo

    2015-01-01

    Introduction Association of knee and low back pain with sleep disturbance is poorly understood. We aimed to clarify the independent and combined effects of these orthopedic symptoms on sleep in a large-scale general population. Methods Cross-sectional data about sleep and knee/low back pain were collected for 9,611 community residents (53±14 years old) by a structured questionnaire. Sleep duration less than 6 h/d was defined as short sleep. Sleep quality and the presence of knee and low back pain were evaluated by dichotomous questions. Subjects who complained about knee or low back pains were graded by tertiles of a numerical response scale (NRS) score and a Roland-Morris disability questionnaire (RDQ) score respectively. Multivariate regression analyses were performed to determine the correlates of short sleep duration and poor sleep quality. Results Frequency of participants who complained of the orthopedic symptoms was as follows; knee pain, 29.0%; low back pain, 42.0% and both knee and low back pain 17.6%. Both knee and low back pain were significantly and independently associated with short sleep duration (knee pain: odds ratio (OR) = 1.19, p<0.01; low back pain: OR = 1.13, p = 0.01) and poor sleep quality (knee pain: OR = 1.22, p<0.01; low back pain; OR = 1.57, p<0.01). The group in the highest tertile of the NRS or RDQ score had the highest risk for short sleep duration and poor sleep quality except for the relationship between the highest tertile of the RDQ score and short sleep duration.(the highest tertile of the NRS: OR for short sleep duration = 1.31, p<0.01; OR for poor sleep quality = 1.47, p<0.01; the highest tertile of the RDQ: OR for short sleep duration = 1.11, p = 0.12; OR for poor sleep quality = 1.81, p<0.01) Further, coincident knee and low back pain raised the odds ratios for short sleep duration (either of knee or low back pain: OR = 1.10, p = 0.06; both knee and low back pain: OR = 1.40, p<0.01) and poor sleep quality (either of knee or

  16. Theory and experiment in biomedical science

    NASA Astrophysics Data System (ADS)

    Allen, Roland

    2012-10-01

    A physicist might regard a person as a collection of electrons and quarks, and a biologist might regard her as an assemblage of biochemical molecules. But according to some speakers at a recent Welch conference [1] biology is a branch of physics. Then biomedical research is a branch of applied physics. Even if one adopts a more modest perspective, it is still true that physics can contribute strongly to biomedical research. An example on the experimental side is the recent studies of G protein-coupled receptors (targeted by more than 50 percent of therapeutic drugs) using synchrotron radiation and nuclear magnetic resonance. On the theory side, one might classify models as microscopic (e.g., simulations of molecules, ions, or electrons), mesoscopic (e.g., simulations of pathways within a cell), or macroscopic (e.g., calculations of processes involving the whole body). We have recently introduced a new macroscopic method for estimating the biochemical response to pharmaceuticals, surgeries, or other medical interventions, and applied it in a simple model of the response to bariatric surgeries [2]. An amazing effect is that the most widely used bariatric surgery (Roux-en-Y-gastric bypass) usually leads to remission of type 2 diabetes in days, long before there is any significant weight loss (with further beneficial effects in the subsequent months and years). Our results confirm that this effect can be largely explained by the enhanced post-meal excretion of glucagon-like peptide 1 (GLP-1), an incretin that increases insulin secretion from the pancreas, but also suggest that other mechanisms are likely to be involved, possibly including an additional insulin-independent pathway for glucose transport into cells. [4pt] [1] Physical Biology, from Atoms to Medicine, edited by Ahmed H. Zewail (Imperial College Press, London, 2008).[0pt] [2] Roland E. Allen, Tyler D. Hughes, Jia Lerd Ng, Roberto D. Ortiz, Michel Abou Ghantous, Othmane Bouhali, Abdelilah Arredouani

  17. Study protocol of effectiveness of a biopsychosocial multidisciplinary intervention in the evolution of non-speficic sub-acute low back pain in the working population: cluster randomised trial

    PubMed Central

    2010-01-01

    Background Non-specific low back pain is a common cause for consultation with the general practitioner, generating increased health and social costs. This study will analyse the effectiveness of a multidisciplinary intervention to reduce disability, severity of pain, anxiety and depression, to improve quality of life and to reduce the incidence of chronic low back pain in the working population with non-specific low back pain, compared to usual clinical care. Methods/Design A Cluster randomised clinical trial will be conducted in 38 Primary Health Care Centres located in Barcelona, Spain and its surrounding areas. The centres are randomly allocated to the multidisciplinary intervention or to usual clinical care. Patients between 18 and 65 years old (n = 932; 466 per arm) and with a diagnostic of a non-specific sub-acute low back pain are included. Patients in the intervention group are receiving the recommendations of clinical practice guidelines, in addition to a biopsychosocial multidisciplinary intervention consisting of group educational sessions lasting a total of 10 hours. The main outcome is change in the score in the Roland Morris disability questionnaire at three months after onset of pain. Other outcomes are severity of pain, quality of life, duration of current non-specific low back pain episode, work sick leave and duration, Fear Avoidance Beliefs and Goldberg Questionnaires. Outcomes will be assessed at baseline, 3, 6 and 12 months. Analysis will be by intention to treat. The intervention effect will be assessed through the standard error of measurement and the effect-size. Responsiveness of each scale will be evaluated by standardised response mean and receiver-operating characteristic method. Recovery according to the patient will be used as an external criterion. A multilevel regression will be performed on repeated measures. The time until the current episode of low back pain takes to subside will be analysed by Cox regression. Discussion We hope

  18. Validation of a Spanish version of the Spine Functional Index

    PubMed Central

    2014-01-01

    Background The Spine Functional Index (SFI) is a recently published, robust and clinimetrically valid patient reported outcome measure. Objectives The purpose of this study was the adaptation and validation of a Spanish-version (SFI-Sp) with cultural and linguistic equivalence. Methods A two stage observational study was conducted. The SFI was cross-culturally adapted to Spanish through double forward and backward translation then validated for its psychometric characteristics. Participants (n = 226) with various spine conditions of >12 weeks duration completed the SFI-Sp and a region specific measure: for the back, the Roland Morris Questionnaire (RMQ) and Backache Index (BADIX); for the neck, the Neck Disability Index (NDI); for general health the EQ-5D and SF-12. The full sample was employed to determine internal consistency, concurrent criterion validity by region and health, construct validity and factor structure. A subgroup (n = 51) was used to determine reliability at seven days. Results The SFI-Sp demonstrated high internal consistency (α = 0.85) and reliability (r = 0.96). The factor structure was one-dimensional and supported construct validity. Criterion specific validity for function was high with the RMQ (r = 0.79), moderate with the BADIX (r = 0.59) and low with the NDI (r = 0.46). For general health it was low with the EQ-5D and inversely correlated (r = −0.42) and fair with the Physical and Mental Components of the SF-12 and inversely correlated (r = −0.56 and r = −0.48), respectively. The study limitations included the lack of longitudinal data regarding other psychometric properties, specifically responsiveness. Conclusions The SFI-Sp was demonstrated as a valid and reliable spine-regional outcome measure. The psychometric properties were comparable to and supported those of the English-version, however further longitudinal investigations are required. PMID:24972525

  19. Effectiveness of a cognitive behavioural therapy-based rehabilitation programme (Progressive Goal Attainment Program) for patients who are work-disabled due to back pain: study protocol for a multicentre randomised controlled trial

    PubMed Central

    2013-01-01

    Background Psychologically informed rehabilitation programmes such as the Progressive Goal Attainment Program (PGAP) have the potential to address pain-related disability by targeting known psychological factors that inhibit rehabilitation progress. However, no randomised controlled trials of this intervention exist and it has not been evaluated in the Irish health service context. Our objective was to evaluate the clinical efficacy and cost-effectiveness of the PGAP in a multicentre randomised controlled trial with patients who are work-disabled due to back pain. Methods and design Adult patients (ages 18 years and older) with nonmalignant back pain who are work-disabled because of chronic pain and not involved in litigation in relation to their pain were invited to take part. Patients were those who show at least one elevated psychosocial risk factor (above the 50th percentile) on pain disability, fear-based activity avoidance, fatigue, depression or pain catastrophizing. Following screening, patients are randomised equally to the intervention or control condition within each of the seven trial locations. Patients allocated to the control condition receive usual medical care only. Patients allocated to the PGAP intervention condition attend a maximum of 10 weekly individual sessions of structured active rehabilitation in addition to usual care. Sessions are delivered by a clinical psychologist and focus on graded activity, goal-setting, pacing activity and cognitive-behavioural therapy techniques to address possible barriers to rehabilitation. The primary analysis will be based on the amount of change on the Roland Morris Disability Questionnaire posttreatment. We will also measure changes in work status, pain intensity, catastrophizing, depression, fear avoidance and fatigue. Outcome measures are collected at baseline, posttreatment and 12-month follow-up. Health-related resource use is also collected pre- and posttreatment and at 12-month follow-up to evaluate

  20. Numerical wave modelling for seismo-acoustic noise sources: wave model accuracy issues and evidence for variable seismic attenuation

    NASA Astrophysics Data System (ADS)

    Ardhuin, F.; Lavanant, T.; Obrebski, M. J.; Marié, L.; Royer, J.

    2012-12-01

    Nonlinear wave-wave interactions generate noise that numerical ocean wave models may simulate. The accuracy of the noise source predicted by the theory of Longuet-Higgins (1950) and Hasselmann (1963) depends on the realism of the directional wave distribution, which is generally not very well known. Numerical noise models developed by Kedar et al. (2008) and Ardhuin et al. (2010) also suffer from poorly known seismic wave propagation and attenuation properties. Here, several seismic and ocean pressure records are used here to assess the effects of wave modelling errors on the magnitude of noise sources. Measurements within 200~m from the sea surface are dominated by acoustic-gravity modes, for which bottom effects are negligible. These data show that directional wave spectra are well enough reproduced to estimate seismo-acoustic noise sources at frequencies below 0.3~Hz, whith an underestimation of the noise level by about 50%. In larger water depths, the comparison of a numerical noise model with hydrophone records from two open-ocean sites near Hawaii and Kerguelen islands reveal that a) deep ocean acoustic noise at frequencies 0.1 to 1 Hz is consistent with the Rayleigh wave theory, and is well predicted up to 0.4~Hz. b) In particular, evidence of the vertical modes expected theoretically is given by the local maxima in the noise spectrum. c) noise above 0.6 Hz is not well modeled probably due to a poor estimate of the directional properties of high frequency wind-waves, d) the noise level is strongly influenced by bottom properties, in particular the presence of sediments. Further, for continental coastal seismic stations, an accurate model of noise level variability near the noise spectral peak requires an accurate modelling of coastal reflection (Ardhuin and Roland JGR 2012). In cases where noise sources are confined to a small area (e.g. Obrebski et al. GRL 2012), the source amplitude may be factored out, allowing an estimate of seismic attenuation rates

  1. An epidemiological study of low back pain in professional drivers

    NASA Astrophysics Data System (ADS)

    Bovenzi, Massimo; Rui, Francesca; Negro, Corrado; D'Agostin, Flavia; Angotzi, Giuliano; Bianchi, Sandra; Bramanti, Lucia; Festa, GianLuca; Gatti, Silvana; Pinto, Iole; Rondina, Livia; Stacchini, Nicola

    2006-12-01

    The prevalence of low back pain (LBP) was investigated in 598 Italian professional drivers exposed to whole-body vibration (WBV) and ergonomic risk factors (drivers of earth moving machines, fork-lift truck drivers, truck drivers, bus drivers). The control group consisted of a small sample of 30 fire inspectors not exposed to WBV. Personal, occupational and health histories were collected by means of a structured questionnaire. Vibration measurements were performed on representative samples of the machines and vehicles used by the driver groups. From the vibration magnitudes and exposure durations, alternative measures of vibration dose were estimated for each subject. Daily vibration exposure, expressed in terms of 8-h energy-equivalent frequency-weighted acceleration, A(8), averaged 0.28-0.61 (range 0.10-1.18) m s -2 rms in the driver groups. Duration of exposure to WBV ranged between 1 and 41 years. The 7-day and 12-month prevalence of LBP was greater in the driver groups than in the controls. In the professional drivers, the occurrence of 12-month LBP, high intensity of LBP (Von Korff pain scale score ⩾5), and LBP disability (Roland & Morris disability scale score ⩾12) significantly increased with increasing cumulative vibration exposure. Even though several alternative measures of vibration exposure were associated with LBP outcomes, nevertheless a more regular trend of association with LBP was found for vibration dose expressed as ∑ a vit i (m s -2 h), in which the frequency-weighted acceleration, a v, and lifetime exposure duration, t, were given equal weight. In multivariate data analysis, individual characteristics (e.g. age, body mass index) and a physical load index (derived from combining manual materials handling and awkward postures) were significantly associated with LBP outcomes, while psychosocial work factors (e.g. job decision, job support) showed a marginal relation to LBP. This study tends to confirm that professional driving in industry

  2. An Innovative and Portable Multimodal Pain Relief Device for the Management of Neuropathic Low Back Pain - a Study from Kashmir (Southeast Asia).

    PubMed

    Tarfarosh, Shah Faisal Ahmad; Lone, Baseer-Ul-Rasool; Beigh, Mirza-Idrees-Ul-Haq; Manzoor, Mushbiq

    2016-06-29

    We developed a portable multimodal system with seven different mechanisms of pain relief incorporated into a lumbar belt called the Comfort-N-Harmony Belt (C&H belt). Here, we describe the technical details of the system and also summarize the effects of this multimodal pain relieving technology as an adjuvant to analgesics versus analgesics alone, on the level of pain, improvement of psychological status, disability, and the quality of life in the patients with neuropathic low back pain (LBP). We tracked the volunteers who were following up at a tertiary health care center for the complaints of neuropathic LBP of minimum three months duration and were on analgesics alone with no relief in the severity of the pain. Study group A (n = 45) consisted of volunteers with LBP on C&H belt therapy, along with the usually prescribed analgesic intake, and group B (n = 45) with LBP volunteers on analgesics, plus a similar looking but plain leather belt (placebo). For pain, the VAS (Visual Analogue Scale); for anxiety and depression, the (HADS) Hospital Anxiety-Depression Scale; for disability, the RMDQ (Roland Morris Disability Questionnaire); and for quality of life, (NHP) Nottingham-Health-Profile were used before and after the study period.  There were no significant differences in demographic variables between the groups (p < 0.05). After the study period of one month, VAS, RMDQ, NHP-pain, NHP-physical activity, and HADS scores in both groups were significantly improved compared to the pre-treatment scores (p < 0.05). Group A also showed significant improvements in the scores of NHP-energy level and NHP-social isolation (p < 0.05). The post-treatment scores did not significantly show any difference between the two groups (p > 0.05). However, in comparison of pre- and post-treatment scores, the pre-treatment score values of RMDQ, NHP-pain, NHP-physical activity, and NHP-social isolation were much higher in group A compared to the group B, but still these scores were

  3. Revisiting the influence of chain length on the α- and β-relaxations in oligomeric glass formers

    NASA Astrophysics Data System (ADS)

    Ngai, K. L.

    2013-12-01

    Dielectric relaxation measurements of a series of oligo(propylene glycol) dimethyl ethers, CH3-O-[CH2-CH(CH3)-O]N-CH3, including samples with the number of PG units N = 1, 2, 3, 7, 17, 34, and 69, were made by Mattsson et al. [Phys. Rev. Lett. 94, 165701 (2005)] at ambient pressure. The objective of the study was to relate the change of properties of the glass transition dynamics to the number of monomer units N in the chain. Not examined in the previous publication is how the change of the width of the frequency dispersion of the α-relaxation with N is related to the observed change in the α-β bifurcation characterized by the ratio, τα(Tg)/τβ(Tg). In this paper, the frequency dispersion of the dimer, trimer, and heptamer are fitted by the Fourier transform of the Kohlrausch stretched exponential function, ϕ(t) = exp[-(t/τα)1-n]. Determined from experimental data, both τα(Tg)/τβ(Tg) and n increase with N. More interestingly, we find τα(Tg)/τβ(Tg) has approximately the same value as [τα(Tg)/tc]n with tc = 2 ps, in accordance with the prediction of the Coupling Model of approximate relation between τα and τβ given by τβ ≈ (tc)n(τα)1-n. Considered also are previously unpublished dielectric loss spectra of the heptamer taken at different combinations of T and P with τα(T,P) fixed by Roland et al. [Phys. Rev. B 77, 012201 (2008)]. The dielectric loss data show not only the α-loss peaks superpose but also the high frequency flank including the barely resolved JG β-relaxation superposes approximately. This is again consistent with the approximate relation between τα and τβ from the Coupling Model because n is unchanged on varying P and T with τα(T,P) kept constant, and tc is a constant. The additional advance made herein has the benefit of enhancing the impact of the earlier experimental studies of the oligo(propylene glycol) dimethyl ethers on current understanding of the dynamics of glass transition.

  4. Twelfth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Rivera, J.

    1987-01-22

    arrangements and preparing the Proceedings. We also owe great thanks to our students who arranged and operated the audio-visual equipment, specially Jim Lovekin. The Twelfth Workshop was supported by the Geothermal Technology Division of the U. S. Department of Energy through Contract Nos. DE-AS03-80SF11459 and DE-AS07- 84ID12529. We deeply appreciate this continued support. January 1987 Henry J. Ramey, Jr. Paul Kruger Roland N. Horne William E. Brigham Frank G. Miller Jesus Rivera

  5. Role of radiofrequency denervation in lumbar zygapophyseal joint synovitis in baseball pitchers: a clinical experience.

    PubMed

    Vad, Vijay B; Cano, William G; Basrai, Dilshaad; Lutz, Gregory E; Bhat, Atul L

    2003-07-01

    Lumbar zygapophyseal joints have long been considered a source of low back pain with or without leg pain. The objective of this prospective study was to investigate the therapeutic effectiveness of lumbar zygapophyseal joint radiofrequency denervation (RFD) followed by physical therapy, for the treatment of refractory lumbar zygapophyseal joint mediated low back pain secondary to lumbar zygapophyseal joint synovitis, in baseball pitchers. Participants included twelve male baseball pitchers with a diagnosis of lumbar zygapophyseal joint synovitis mediated low back pain and a subsequent difficulty in pitching. These athletes underwent a trial of treatment, including oral anti-inflammatory medication, physical therapy, osteopathic manipulations, and fluoroscopically guided intra-articular zygapophyseal joint injection utilizing steroid and local anesthetic agent. Failure to progress led to these athletes receiving percutaneous, fluoroscopically-guided, radiofrequency denervation of the bilateral L 4-L5 and L5-S1 zygapophyseal joints. A good response to a diagnostic medial branch block was a prerequisite for RFD treatment. In all cases, the medial branch above and below the involved level was treated. Post procedure, all athletes participated in a phased physical therapy program followed by a progressive return to pitching. Success was defined as the ability to return to pre-procedure level of baseball pitching combined with greater than 50% low back pain reduction. Pre- and post-RFD, Visual Analog (Numeric) Scale (VAS) and Roland-Morris (R-M) tests were administered. Ten out of 12 (83%) athletes were able to return to pitching at a level attained prior to RFD. All 12 patients, experienced statistically significant low back pain relief, with a mean pre-RFD VAS of 8.4; mean post-RFD VAS of 1.7; mean pre-RFD R-M score of 12.3; and mean post-RFD R-M score of 22.3. In conclusion, athletes, experiencing lumbar zygapophyseal joint mediated low back pain secondary to

  6. Effectiveness of a 'Global Postural Reeducation' program for persistent Low Back Pain: a non-randomized controlled trial

    PubMed Central

    2010-01-01

    Background The aim of this non-randomized controlled trial was to evaluate the effectiveness of a Global Postural Reeducation (GPR) program as compared to a Stabilization Exercise (SE) program in subjects with persistent low back pain (LBP) at short- and mid-term follow-up (ie. 3 and 6 months). Methods According to inclusion and exclusion criteria, 100 patients with a primary complaint of persistent LBP were enrolled in the study: 50 were allocated to the GPR group and 50 to the SE group. Primary outcome measures were Roland and Morris Disability Questionnaire (RMDQ) and Oswestry Disability Index (ODI). Secondary outcome measures were lumbar Visual Analogue Scale (VAS) and Fingertip-to-floor test (FFT). Data were collected at baseline and at 3/6 months by health care professionals unaware of the study. An intention to treat approach was used to analyze participants according to the group to which they were originally assigned. Results Of the 100 patients initially included in the study, 78 patients completed the study: 42 in the GPR group and 36 in the SE group. At baseline, the two groups did not differ significantly with respect to gender, age, BMI and outcome measures. Comparing the differences between groups at short- and mid-term follow-up, the GPR group revealed a significant reduction (from baseline) in all outcome measures with respect to the SE group. The ordered logistic regression model showed an increased likelihood of definitive improvement (reduction from baseline of at least 30% in RMDQ and VAS scores) for the GPR group compared to the SE group (OR 3.9, 95% CI 2.7 to 5.7). Conclusions Our findings suggest that a GPR intervention in subjects with persistent LBP induces a greater improvement on pain and disability as compared to a SE program. These results must be confirmed by further studies with higher methodological standards, including randomization, larger sample size, longer follow-up and subgrouping of the LBP subjects. Trial registration NCT

  7. Yoga vs. physical therapy vs. education for chronic low back pain in predominantly minority populations: study protocol for a randomized controlled trial

    PubMed Central

    2014-01-01

    Background Chronic low back pain causes substantial morbidity and cost to society while disproportionately impacting low-income and minority adults. Several randomized controlled trials show yoga is an effective treatment. However, the comparative effectiveness of yoga and physical therapy, a common mainstream treatment for chronic low back pain, is unknown. Methods/Design This is a randomized controlled trial for 320 predominantly low-income minority adults with chronic low back pain, comparing yoga, physical therapy, and education. Inclusion criteria are adults 18–64 years old with non-specific low back pain lasting ≥12 weeks and a self-reported average pain intensity of ≥4 on a 0–10 scale. Recruitment takes place at Boston Medical Center, an urban academic safety-net hospital and seven federally qualified community health centers located in diverse neighborhoods. The 52-week study has an initial 12-week Treatment Phase where participants are randomized in a 2:2:1 ratio into i) a standardized weekly hatha yoga class supplemented by home practice; ii) a standardized evidence-based exercise therapy protocol adapted from the Treatment Based Classification method, individually delivered by a physical therapist and supplemented by home practice; and iii) education delivered through a self-care book. Co-primary outcome measures are 12-week pain intensity measured on an 11-point numerical rating scale and back-specific function measured using the modified Roland Morris Disability Questionnaire. In the subsequent 40-week Maintenance Phase, yoga participants are re-randomized in a 1:1 ratio to either structured maintenance yoga classes or home practice only. Physical therapy participants are similarly re-randomized to either five booster sessions or home practice only. Education participants continue to follow recommendations of educational materials. We will also assess cost effectiveness from the perspectives of the individual, insurers, and society using

  8. Effectiveness of massage therapy for subacute low-back pain: a randomized controlled trial

    PubMed Central

    Preyde, M

    2000-01-01

    BACKGROUND: The effectiveness of massage therapy for low-back pain has not been documented. This randomized controlled trial compared comprehensive massage therapy (soft-tissue manipulation, remedial exercise and posture education), 2 components of massage therapy and placebo in the treatment of subacute (between 1 week and 8 months) low-back pain. METHODS: Subjects with subacute low-back pain were randomly assigned to 1 of 4 groups: comprehensive massage therapy (n = 25), soft-tissue manipulation only (n = 25), remedial exercise with posture education only (n = 22) or a placebo of sham laser therapy (n = 26). Each subject received 6 treatments within approximately 1 month. Outcome measures obtained at baseline, after treatment and at 1-month follow-up consisted of the Roland Disability Questionnaire (RDQ), the McGill Pain Questionnaire (PPI and PRI), the State Anxiety Index and the Modified Schober test (lumbar range of motion). RESULTS: Of the 107 subjects who passed screening, 98 (92%) completed post-treatment tests and 91 (85%) completed follow-up tests. Statistically significant differences were noted after treatment and at follow-up. The comprehensive massage therapy group had improved function (mean RDQ score 1.54 v. 2.86-6.5, p < 0.001), less intense pain (mean PPI score 0.42 v. 1.18-1.75, p < 0.001) and a decrease in the quality of pain (mean PRI score 2.29 v. 4.55-7.71, p = 0.006) compared with the other 3 groups. Clinical significance was evident for the comprehensive massage therapy group and the soft-tissue manipulation group on the measure of function. At 1-month follow-up 63% of subjects in the comprehensive massage therapy group reported no pain as compared with 27% of the soft-tissue manipulation group, 14% of the remedial exercise group and 0% of the sham laser therapy group. INTERPRETATION: Patients with subacute low-back pain were shown to benefit from massage therapy, as regulated by the College of Massage Therapists of Ontario and delivered by

  9. Aerobic exercise reduces neuronal responses in food reward brain regions.

    PubMed

    Evero, Nero; Hackett, Laura C; Clark, Robert D; Phelan, Suzanne; Hagobian, Todd A

    2012-05-01

    Acute exercise suppresses ad libitum energy intake, but little is known about the effects of exercise on food reward brain regions. After an overnight fast, 30 (17 men, 13 women), healthy, habitually active (age = 22.2 ± 0.7 yr, body mass index = 23.6 ± 0.4 kg/m(2), Vo(2peak) = 44.2 ± 1.5 ml·kg(-1)·min(-1)) individuals completed 60 min of exercise on a cycle ergometer or 60 min of rest (no-exercise) in a counterbalanced, crossover fashion. After each condition, blood oxygen level-dependent responses to high-energy food, low-energy food, and control visual cues, were measured by functional magnetic resonance imaging. Exercise, compared with no-exercise, significantly (P < 0.005) reduced the neuronal response to food (high and low food) cues vs. control cues in the insula (-0.37 ± 0.13 vs. +0.07 ± 0.18%), putamen (-0.39 ± 0.10 vs. -0.10 ± 0.09%), and rolandic operculum (-0.37 ± 0.17 vs. 0.17 ± 0.12%). Exercise alone significantly (P < 0.005) reduced the neuronal response to high food vs. control and low food vs. control cues in the inferior orbitofrontal cortex (-0.94 ± 0.33%), insula (-0.37 ± 0.13%), and putamen (-0.41 ± 0.10%). No-exercise alone significantly (P < 0.005) reduced the neuronal response to high vs. control and low vs. control cues in the middle (-0.47 ± 0.15%) and inferior occipital gyrus (-1.00 ± 0.23%). Exercise reduced neuronal responses in brain regions consistent with reduced pleasure of food, reduced incentive motivation to eat, and reduced anticipation and consumption of food. Reduced neuronal response in these food reward brain regions after exercise is in line with the paradigm that acute exercise suppresses subsequent energy intake.

  10. Program and abstracts of the Second Tsunami Source Workshop; July 19-20, 2010

    USGS Publications Warehouse

    Lee, W.H.K.; Kirby, S.H.; Diggles, M.F.

    2010-01-01

    In response to a request by the National Oceanic and Atmospheric Administration (NOAA) for computing tsunami propagations in the western Pacific, Eric Geist asked Willie Lee for assistance in providing parameters of earthquakes which may be future tsunami sources. The U.S. Geological Survey (USGS) Tsunami Source Working Group (TSWG) was initiated in August 2005. An ad hoc group of diverse expertise was formed, with Steve Kirby as the leader. The founding members are: Rick Blakely, Eric Geist, Steve Kirby, Willie Lee, George Plafker, Dave Scholl, Roland von Huene, and Ray Wells. Half of the founding members are USGS emeritus scientists. A report was quickly completed because of NOAA's urgent need to precalculate tsunami propagation paths for early warning purposes. It was clear to the group that much more work needed to be done to improve our knowledge about tsunami sources worldwide. The group therefore started an informal research program on tsunami sources and meets irregularly to share ideas, data, and results. Because our group activities are open to anyone, we have more participants now, including, for example, Harley Benz and George Choy (USGS, Golden, Colo.), Holly Ryan and Stephanie Ross (USGS, Menlo Park, Calif.), Hiroo Kanamori (Caltech), Emile Okal (Northwestern University), and Gerard Fryer and Barry Hirshorn (Pacific Tsunami Warning Center, Hawaii). To celebrate the fifth anniversary of the TSWG, a workshop is being held in the Auditorium of Building 3, USGS, Menlo Park, on July 19-20, 2010 (Willie Lee and Steve Kirby, Conveners). All talks (except one) will be video broadcast. The first tsunami source workshop was held in April 2006 with about 100 participants from many institutions. This second workshop (on a much smaller scale) will be devoted primarily to recent work by the USGS members. In addition, Hiroo Kanamori (Caltech) will present his recent work on the 1960 and 2010 Chile earthquakes, Barry Hirshorn and Stuart Weinstein (Pacific Tsunami

  11. Revisiting an interdisciplinary hydrological modelling project. A socio-hydrology (?) example from the early 2000s

    NASA Astrophysics Data System (ADS)

    Seidl, Roman; Barthel, Roland

    2016-04-01

    Interdisciplinary scientific and societal knowledge plays an increasingly important role in global change research. Also, in the field of water resources interdisciplinarity as well as cooperation with stakeholders from outside academia have been recognized as important. In this contribution, we revisit an integrated regional modelling system (DANUBIA), which was developed by an interdisciplinary team of researchers and relied on stakeholder participation in the framework of the GLOWA-Danube project from 2001 to 2011 (Mauser and Prasch 2016). As the model was developed before the current increase in literature on participatory modelling and interdisciplinarity, we ask how a socio-hydrology approach would have helped and in what way it would have made the work different. The present contribution firstly presents the interdisciplinary concept of DANUBIA, mainly with focus on the integration of human behaviour in a spatially explicit, process-based numerical modelling system (Roland Barthel, Janisch, Schwarz, Trifkovic, Nickel, Schulz, and Mauser 2008; R. Barthel, Nickel, Meleg, Trifkovic, and Braun 2005). Secondly, we compare the approaches to interdisciplinarity in GLOWA-Danube with concepts and ideas presented by socio-hydrology. Thirdly, we frame DANUBIA and a review of key literature on socio-hydrology in the context of a survey among hydrologists (N = 184). This discussion is used to highlight gaps and opportunities of the socio-hydrology approach. We show that the interdisciplinary aspect of the project and the participatory process of stakeholder integration in DANUBIA were not entirely successful. However, important insights were gained and important lessons were learnt. Against the background of these experiences we feel that in its current state, socio-hydrology is still lacking a plan for knowledge integration. Moreover, we consider necessary that socio-hydrology takes into account the lessons learnt from these earlier examples of knowledge integration

  12. Open-label, randomized, controlled pilot study of the effects of a glucosamine complex on Low back pain

    PubMed Central

    Tant, Laure; Gillard, Bruno; Appelboom, Thierry

    2005-01-01

    Background: A series of studies has suggested some efficacy of glucosamine in arthrosis of the knee, but virtually no documentation exists regarding its effects on low back pain. Objectives: The primary objective of this study was to examine whether a 12-week course of a glucosamine complex (GC) could benefit patients having low back pain despite a course of noninvasive physical therapy. In addition, we sought to delineate the subgroup of responders. Methods: This open-label, randomized, controlled study was conducted at the Division of Rheumatology and Physical Medicine, Erasme University Hospital, Brussels, Belgium. Male and female outpatients aged 40 to 80 years with low back pain (duration, ≥ 12 weeks; pain score on 10-cm visual analog scale [VAS] [0 = none to 10 = worst imaginable], ≥3 cm) despite noninvasive physical therapy (massage, stretching, heat application, and analgesics for ≥4 weeks) were included. Patients were randomly assigned to receive, in addition to conventional treatment (CT) (physical therapy plus analgesics/antiinflammatories), a GC (enriched with sulfonyl methane, silicon, and a botanical extract of Ribes nigrum) or CT alone (control) for 12 weeks. Pain at rest and on movement (effort) and early morning lumbar stiffness were measured every 4 weeks using the VAS. The primary end point was improvement in VAS score for pain at rest at 12 weeks. Two validated questionnaires were used to assess improvements in quality of life (QOL) (Oswestry Disability Questionnaire [ODQ] [10 items; scale: 0 = no disability to 60 = maximal disability] and Roland-Morris Disability Questionnaire [RMDQ] [24 items; scale: 0 = no disability to 24 = severe disability]). Responders were defined as patients who positively assessed the efficacy of the GC. At each visit, patients were also asked about possible adverse events. Results: Of 36 enrolled patients, 32 completed the study (18 men, 14 women; mean [SE] age, 64 [2] years; 17 in the GC group and 15 in the

  13. The application of simple mass spectrometers to planetary sub-surface sampling using penetrators

    NASA Astrophysics Data System (ADS)

    Sheridan, Simon; Morse, Andrew; Bardwell, Max; Barber, Simeon; Wright, Ian

    2010-05-01

    (1-4), 363-387. Todd, J.F.J., Barber, S.J., Wright, I.P., Morgan, G.H., Morse, A.D., Sheridan, S., Leese, M.R., Maynard, J., Evans, S.T., Pillinger, C.T. et al. (2007). Ion trap mass spectrometry on a comet nucleus: the Ptolemy instrument and the Rosetta space mission. J. Mass Spectrom. 42,1-10. Pillinger C. T., and Wright I. P. (1993). MODULUS - Methods Of Determining and Understanding Light elements from Unequivocal Stable isotope composition. A type 2 proposal submitted to the RoLand Cometary Lander of the ESA International Rosetta Mission for the provision of Ptolemy - an evolved gas analyser. Richter L., Coste P., Grzesik A., Magnani P., Nadalini R., Neuhaus D., Re E., Romstedt J., Sims M. and Sohl F. (2005). Instrumented Moles for Planetary Subsurface Regolith Studies. Geophysical Research Abstracts, Vol. 7, 08659 A. Smith A.,. Crawford I. A., Gowen R. A., Ball A. J., Barber S. J., Church P., Coates A. J., Gao Y., Griffiths A. D., Hagermann A.,•Joy K. H., Phipps A., Pike W. T., Scott R., Sheridan S., Sweeting M., Talboys D.,•Tong V.,•Wells N.,• Biele J., Chela-Flores J.,•Dabrowski B., Flannagan J., Grande M., Grygorczuk J., Kargl G.,. Khavroshkin O. B.,•Klingelhoefer G., Knapmeyer M.,• Marczewski W., McKenna-Lawlor S.,•Richter L., Rothery D. A., Seweryn K., Ulamec S., Wawrzaszek R., Wieczorek M., Wright I. P. and Sims M. (2009). LunarEX - a proposal to cosmic vision. Exp Astron 23:711-740: DOI 10.1007/s10686-008-9109-6

  14. Neural underpinnings for model-oriented therapy of aphasic word production.

    PubMed

    Abel, Stefanie; Weiller, Cornelius; Huber, Walter; Willmes, Klaus

    2014-05-01

    /superior frontal gyrus for the phonological method. (4) Impairment-specific changes of activation were found for P-patients in left IFGoper. Patients with semantic disorders (S-patients) relied on right frontal areas involving IFG, pars triangularis. After therapy, they revealed less activation decrease in areas involving left STG, caudate, paracentral lobule, and right rolandic operculum. Regarding naming performance, the present study corroborates previous findings on training and generalisation effects and reveals differential therapy effects for P-patients. Moreover, brain imaging results confirm a predominance of (1) general effects in the left brain hemisphere. (2) Brain regions related to visual strategy, monitoring/feedback, and articulatory patterns were characteristic for the familiar trained items. (3) Distinct regions associated with strategies, monitoring capacities, and linguistic information indicate the specific therapeutic influence on word retrieval. (4) While P-patients relied more on preserved phonological functions in the left hemisphere, S-patients revealed right-sided compensation of semantic processing as well as increased strategic efforts in both hemispheres.

  15. Effects of Mindfulness-Based Stress Reduction vs Cognitive-Behavioral Therapy and Usual Care on Back Pain and Functional Limitations among Adults with Chronic Low Back Pain: A Randomized Clinical Trial

    PubMed Central

    Cherkin, Daniel C.; Sherman, Karen J.; Balderson, Benjamin H.; Cook, Andrea J.; Anderson, Melissa L.; Hawkes, Rene J.; Hansen, Kelly E.; Turner, Judith A.

    2016-01-01

    Importance Mindfulness-based stress reduction (MBSR) has not been rigorously evaluated for young and middle-aged adults with chronic low back pain. Objective To evaluate the effectiveness for chronic low back pain of MBSR versus usual care (UC) and cognitive-behavioral therapy (CBT). Design, Setting, and Participants Randomized, interviewer-blind, controlled trial in integrated healthcare system in Washington State of 342 adults aged 20–70 years with CLBP enrolled between September 2012 and April 2014 and randomly assigned to MBSR (n = 116), CBT (n = 113), or UC (n = 113). Interventions CBT (training to change pain-related thoughts and behaviors) and MBSR (training in mindfulness meditation and yoga) were delivered in 8 weekly 2-hour groups. UC included whatever care participants received. Main Outcomes and Measures Co-primary outcomes were the percentages of participants with clinically meaningful (≥30%) improvement from baseline in functional limitations (modified Roland Disability Questionnaire [RDQ]; range 0 to 23) and in self-reported back pain bothersomeness (0 to 10 scale) at 26 weeks. Outcomes were also assessed at 4, 8, and 52 weeks. Results Among 342 randomized participants (mean age, 49 (range, 20–70); 225 (66%) women; mean duration of back pain, 7.3 years (range 3 months to 50 years), <60% attended 6 or more of the 8 sessions, 294 (86.0%) completed the study at 26 weeks and 290 (84.8%) completed the study 52weeks. In intent-to-treat analyses, at 26 weeks, the percentage of participants with clinically meaningful improvement on the RDQ was higher for MBSR (61%) and CBT (58%) than for UC (44%) (overall P = 0.04; MBSR versus UC: RR [95% CI] = 1.37 [1.06 to 1.77]; MBSR versus CBT: 0.95 [0.77 to 1.18]; CBT versus UC: 1.31 [1.01 to 1.69]. The percentage of participants with clinically meaningful improvement in pain bothersomeness was 44% in MBSR and 45% in CBT, versus 27% in UC (overall P = 0.01; MBSR versus UC: 1.64 [1.15 to 2.34]; MBSR versus CBT: 1

  16. Salix polaris growth responses to active layer detachment and solifluction processes in High Arctic.

    NASA Astrophysics Data System (ADS)

    Siekacz, Liliana

    2015-04-01

    participation of missing and partially missing rings. Share of missing rings in shrubs growing within an active layer detachment on the valley slope reached 16,22% and 15,36%. Even higher variation is observed in partially missing rings which account for 31,07% within detachment and 23,39% on surrounding slope. Those values are more than twice higher comparing to the valley floor. There is also noticeable difference between detachment and surrounding slope indicating that wedging rings are an effect of mechanical stress that is higher within the detachment. Comparing growth patterns in aboveground and belowground plant parts different growth allocation is noticed. Years of detachment event growth rings were present only in aboveground parts. It is supposed that mechanical stress delays the onset of the growing season similarly to low temperatures (Buchwał et al., 2013), resulting in not enough time to fully allocate resources for growth in the belowground parts. Growth pattern is extremely irregular, indicating that the slope is in constant movement, which disrupts growth conditions. Analyzed shrubs showed two possible event years: 2006 and 2008, with the highest participation of missing and partially missing rings. Air and ground temperature data were also analyzed and confirmed that active layer detachment happened in 2006. REFERENCES Buchwał A, Rachlewicz G, Fonti P, Cherubini P, Gärtner H, (2013) Temperature modulates intra-plant growth of Salix Polaris from a high Arctic site (Svalbard). Polar Biol 36:1305-1318. Hagen J O, Liestøl O, Roland E, Jørgensen T, (1993) Glacier atlas of Svalbard and Jan Mayen. Norsk Polarinstitutt Meddelelser 129: 160. Rachlewicz G, (2009) Contemporary sediment fluxes and relief changes in high Arctic glacierized valley systems (Billefjorden, Central Spitsbergen). Wyd. Nauk. UAM Poznań, seria Geografia 87:204. Schweingruber FH, Poschlod P, (2005) Growth rings in herbs and shrubs: life span, age determination and stem anatomy. For Snow

  17. COIN Project: Towards a zero-waste technology for concrete aggregate production in Norway

    NASA Astrophysics Data System (ADS)

    Cepuritis, Rolands; Willy Danielsen, Svein

    2014-05-01

    COIN Project: Towards a zero-waste technology for concrete aggregate production in Norway Rolands Cepuritis, Norcem/NTNU and Svein Willy Danielsen, SINTEF Aggregate production is a mining operation where no purification of the "ore" is necessary. Still it is extremely rare that an aggregate production plant is operating on the basis of zero-waste concept. This is since historically the fine crushed aggregate (particles with a size of less than 2, 4 or sometimes 8 mm) has been regarded as a by-product or waste of the more valuable coarse aggregate production. The reason is that the crushed coarse aggregates can easily replace coarse rounded natural stones in almost any concrete composition; while, the situation with the sand is different. The production of coarse aggregate normally yields fine fractions with rough surface texture, flaky or elongated particles an inadequate gradation. When such a material replaces smooth and rounded natural sand grains in a concrete mix, the result is usually poor and much more water and cement has to be used to achieve adequate concrete flow. The consequences are huge stockpiles of the crushed fine fractions that can't be sold (mass balance problems) for the aggregate producers, sustainability problems for the whole industry and environmental issues for society due to dumping and storing of the fine co-generated material. There have been attempts of utilising the material in concrete before; however, they have mostly ended up in failure. There have been attempts to adjust the crushed sand to the properties of the natural sand, which would still give a lot of waste, especially if the grading would have to be adjusted and the high amounts of fines abundantly present in the crushed sand would have to be removed. Another fundamental reason for failure has been that historically such attempts have mainly ended up in a research carried out by people (both industrial and academic) with aggregate background (= parties willing to find market

  18. Assessment of coal geology, resources, and reserves in the Montana Powder River Basin

    USGS Publications Warehouse

    Haacke, Jon E.; Scott, David C.; Osmonson, Lee M.; Luppens, James A.; Pierce, Paul E.; Gunderson, Jay A.

    2013-01-01

    The purpose of this report is to summarize geology, coal resources, and coal reserves in the Montana Powder River Basin assessment area in southeastern Montana. This report represents the fourth assessment area within the Powder River Basin to be evaluated in the continuing U.S. Geological Survey regional coal assessment program. There are four active coal mines in the Montana Powder River Basin assessment area: the Spring Creek and Decker Mines, both near Decker; the Rosebud Mine, near Colstrip; and the Absaloka Mine, west of Colstrip. During 2011, coal production from these four mines totaled approximately 36 million short tons. A fifth mine, the Big Sky, had significant production from 1969-2003; however, it is no longer in production and has since been reclaimed. Total coal production from all five mines in the Montana Powder River Basin assessment area from 1968 to 2011 was approximately 1.4 billion short tons. The Rosebud/Knobloch coal bed near Colstrip and the Anderson, Dietz 2, and Dietz 3 coal beds near Decker contain the largest deposits of surface minable, low-sulfur, subbituminous coal currently being mined in the assessment area. A total of 26 coal beds were identified during this assessment, 18 of which were modeled and evaluated to determine in-place coal resources. The total original coal resource in the Montana Powder River Basin assessment area for the 18 coal beds assessed was calculated to be 215 billion short tons. Available coal resources, which are part of the original coal resource remaining after subtracting restrictions and areas of burned coal, are about 162 billion short tons. Restrictions included railroads, Federal interstate highways, urban areas, alluvial valley floors, state parks, national forests, and mined-out areas. It was determined that 10 of the 18 coal beds had sufficient areal extent and thickness to be evaluated for recoverable surface resources ([Roland (Baker), Smith, Anderson, Dietz 2, Dietz 3, Canyon, Werner

  19. Pedometer-Based Internet-Mediated Intervention For Adults With Chronic Low Back Pain: Randomized Controlled Trial

    PubMed Central

    Kadri, Reema; Hughes, Maria; Kerr, Eve A; Piette, John D; Holleman, Rob; Kim, Hyungjin Myra; Richardson, Caroline R

    2013-01-01

    Background Chronic pain, especially back pain, is a prevalent condition that is associated with disability, poor health status, anxiety and depression, decreased quality of life, and increased health services use and costs. Current evidence suggests that exercise is an effective strategy for managing chronic pain. However, there are few clinical programs that use generally available tools and a relatively low-cost approach to help patients with chronic back pain initiate and maintain an exercise program. Objective The objective of the study was to determine whether a pedometer-based, Internet-mediated intervention can reduce chronic back pain-related disability. Methods A parallel group randomized controlled trial was conducted with 1:1 allocation to the intervention or usual care group. 229 veterans with nonspecific chronic back pain were recruited from one Department of Veterans Affairs (VA) health care system. Participants randomized to the intervention received an uploading pedometer and had access to a website that provided automated walking goals, feedback, motivational messages, and social support through an e-community (n=111). Usual care participants (n=118) also received the uploading pedometer but did not receive the automated feedback or have access to the website. The primary outcome was measured using the Roland Morris Disability Questionnaire (RDQ) at 6 months (secondary) and 12 months (primary) with a difference in mean scores of at least 2 considered clinically meaningful. Both a complete case and all case analysis, using linear mixed effects models, were conducted to assess differences between study groups at both time points. Results Baseline mean RDQ scores were greater than 9 in both groups. Primary outcome data were provided by approximately 90% of intervention and usual care participants at both 6 and 12 months. At 6 months, average RDQ scores were 7.2 for intervention participants compared to 9.2 for usual care, an adjusted difference of 1

  20. Characteristics of 3-component Magnetic Fields of Equatorial Pi 2s - MAGDAS/CPMN Observations in Daytime and Nighttime -

    NASA Astrophysics Data System (ADS)

    Hirayama, Y.; Yumoto, K.; Uozumi, T.; Yoshikawa, A.; Group, M.

    2008-12-01

    .1 at DAV respectively. The amplitude ratio of H-component Pi 2s at DAV to CEB is found to be almost 1.5 constantly in night in all season, indicating the CA effect of equatorial Pi 2. The enhancement of the ratio of D-component to H- component at around sunrise and sunset may be explained by the meridional ionospheric current of equatorial Pi 2, but more future study is needed. Acknowledgements We appreciate the following Co-investigators for their contribution to the MAGDAS/CPMN project; Dr. Baylie Damtie(Bahir Dar University, AAB), Dr. Ronald Woodman Pollitt and Dr. Jose Ishitsuka (Instituto Geofisico del Peru, ANC), Dr. Roland Emerito S. Otadoy(University of San Carlos, CEB), Fr. Daniel McNamara(Manila Observatory, DAV), Dr. Severino L. G. Dutra(Brazilian National Space Research Institute, EUS) and Dr. Mazlan Othman and Dr. Mohd Fairos (National Space Agency, LKW). We appreciate Dr. Shinichi Watari(National Institute of Information and Communications Technology) providing the magnetic field data of YAP.

  1. Observations of Anomalous Subcrustal Reflections Along the East Pacific Rise: Possible Detection of a Melt Permeability Barrier

    NASA Astrophysics Data System (ADS)

    Arnoux, G. M.; Toomey, D. R.

    2013-12-01

    Crustal accretion at mid-ocean ridges primarily occurs within the narrow neovolcanic zone at the spreading axis, with supplementary lower crustal accumulation thought to originate from the crystallization of magma bodies at the base of the crust. The narrowness of the neovolcanic zone requires melt focusing - a process that has been proposed to arise from the presence of melt impermeable boundaries, or permeability barriers, within the thermal boundary layer near the base of the lithosphere that inhibit the upward migration of melt, effectively focusing it laterally to the ridge axis. Numerical simulations, as well as structural and petrological characteristics of the Oman ophiolite, suggest the existence of such melt impermeable boundaries. A recent analysis of seismic data from the East Pacific Rise (EPR) between the Siqueiros and Clipperton transform faults (8°15'N-10°20'N) reveals anomalous subcrustal reflections ~20 km east of the rise axis and ~20-50 km south of the Clipperton transform. The reflections are characterized by large amplitudes, high frequency content on the order of 20-30 Hz, and a travel time curve that is parabolic with arrival times increasing rapidly at ranges <20 km from the receiver. The approximate depth, slope, and geographical extent of the reflector are estimated by back projecting the onset times of the anomalous reflections into a predefined velocity model. This method reveals that the reflector dips both away from the ridge axis and northward toward the Clipperton transform with a minimum depth below seafloor of ~7.2 km (0.7 km below the Moho) nearest to the ridge. Further off-axis and roughly 20 km to the north, closest to the Clipperton transform, the depth of the reflector increases to ~10.6 km (4 km below the Moho). The slope of the observed reflector thus conforms to the base of the thermal boundary layer (i.e. the 1200-1300° C isotherms) in thermal models adjacent to oceanic transform faults (Roland et al., 2010). The 1240

  2. Frictional Behavior of Oceanic Transform Faults and Influence on Earthquake Characteristics

    NASA Astrophysics Data System (ADS)

    Liu, Y.; Behn, M. D.; McGuire, J. J.

    2010-12-01

    zone W is the largest, resulting in an extremely low coupling coefficient of order 10-5. For the long/slow case, greater earthquakes of magnitude 6 or 7 repeat every 80-120 years due to a much larger AT. The largest earthquake continues to nucleate where W is the largest, while smaller earthquakes also emerge at locations closer to the ridges. The seismic coupling coefficient is close to 0.15, the average estimate by Boettcher and Jordan [JGR, 2004]. We plan to perform earthquake cycle calculations on RTFs of various configurations to construct the scaling relations and compare to the above observations, in order to understand the mechanism(s) for seismic and aseismic slip partitioning on RTFs. A more sophisticated thermal model that incorporates realistic oceanic lithosphere rheology and effects of shear heating and hydrothermal circulation [Roland et al., Gcubed, 2010] will be used to constrain the friction parameter distribution. Specifically, we will focus on the Quebrada, Discovery and Gofar fault system on the East Pacific Rise, where abundant OBS data are available to constrain our model, to study the conditions that control the transition between aseismic and seismic slip, and the presence of a frictional barrier and its effects on earthquake rupture.

  3. Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients.

    PubMed

    Magnin, M; Morel, A; Jeanmonod, D

    2000-01-01

    exhibiting random or rhythmic low-threshold calcium spike bursts were found preponderantly in the ventral anterior nucleus (53.4%) and in the ventral lateral anterior nucleus (52.7%). Tremor-locked units were confined to the ventral division of the ventral lateral posterior nucleus (35.4%). None of the random or rhythmic low-threshold calcium spike bursting units responded to somatosensory stimuli or voluntary movements, either in the medial or in the lateral thalamus. The presence of low-threshold calcium spike bursts at the thalamic level, together with the paucity (8%) of responses to voluntary movements compared to what is found in normal non-human primates, demonstrate a pathological state of inhibition due to the overactivity of the internal subdivision of the globus pallidus units. Activities of the thalamic cells producing low-threshold calcium spike bursts are not synchronized with each other or with the tremor. However, this does not exclude a causal role of these activities in the generation of tremor. Indeed, it has been demonstrated that even random electrical stimulations of the rolandic cortex in parkinsonian patients induce tremor episodes, probably due to the triggering of rhythmic, low-threshold calcium spike-dependent, thalamocortical activities. Similarly, low-threshold calcium spike bursts could be at the origin of rigidity and dystonia through an activation of the supplementary motor area and of akinesia when reaching the pre-supplementary motor area. We conclude that the intrinsic oscillatory properties of individual neurons, combined with the dynamic properties of the thalamocortical circuitry, are responsible for the three cardinal parkinsonian symptoms.

  4. History of infrared optronics in France

    NASA Astrophysics Data System (ADS)

    Fouilloy, J. P.; Siriex, Michel B.

    1995-09-01

    In France, the real start of work on the applications of infrared radiations occurred around 1947 - 1948. During many years, technological research was performed in the field of detectors, optical material, modulation techniques, and a lot of measurements were made in order to acquire a better knowledge of the propagation medium and radiation of IR sources, namely those of jet engines. The birth of industrial infrared activities in France started with the Franco-German missile guidance programs: Milan, HOT, Roland and the French air to air missile seeker programs: R530, MAGIC. At these early stages of IR technologies development, it was a great technical adventure for both the governmental agencies and industry to develop: detector technology with PbS and InSb, detector cooling for 3 - 5 micrometer wavelength range, optical material transparent in the infrared, opto mechanical design, signal processing and related electronic technologies. Etablissement Jean Turck and SAT were the pioneers associated with Aerospatiale, Matra and under contracts from the French Ministry of Defence (DGA). In the 60s, the need arose to enhance night vision capability of equipment in service with the French Army. TRT was chosen by DGA to develop the first thermal imagers: LUTHER 1, 2, and 3 with an increasing number of detectors and image frequency rate. This period was also the era in which the SAT detector made rapid advance. After basic work done in the CNRS and with the support of DGA, SAT became the world leader of MCT photovoltaic detector working in the 8 to 12 micron waveband. From 1979, TRT and SAT were given the responsibility for the joint development and production of the first generation French thermal imaging modular system so-called SMT. Now, THOMSON TTD Optronique takes over the opto-electronics activities of TRT. Laser based systems were also studied for military application using YAG type laser and CO2 laser: Laboratoire de Marcousis, CILAS, THOMSON CSF and SAT have

  5. 3d-modelling workflows for trans-nationally shared geological models - first approaches from the project GeoMol

    NASA Astrophysics Data System (ADS)

    Rupf, Isabel

    2013-04-01

    framework model are interpreted seismic lines, 3d-models can be generated either in time or in depth domain. Some partners will build their 3d-model in time domain and convert it after finishing to depth. Other participants will transform seismic information first and will model directly in depth domain. To ensure comparability between the different parts transnational velocity models for time-depth conversion are required at an early stage of the project. The exchange of model geometries, topology, and geo-scientific content will be achieved applying an appropriate cyberinfrastructure called GST. It provides functionalities to ensure semantic and technical interoperability. Within the project GeoMol a web server for the dissemination of 3d geological models will be implemented including an administrative interface for the role-based access, real-time transformation of country-specific coordinate systems and a web visualisation features. The project GeoMol is co-funded by the Alpine Space Program as part of the European Territorial Cooperation 2007-2013. The project integrates partners from Austria, France, Germany, Italy, Slovenia and Switzerland and runs from September 2012 to June 2015. Further information on www.geomol.eu. The GeoMol 3D-modelling team: Roland Baumberger (swisstopo), Magdalena Bottig (GBA), Alessandro Cagnoni (RLB), Laure Capar (BRGM), Renaud Couëffé (BRGM), Chiara D'Ambrogi (ISPRA), Chrystel Dezayes (BRGM), Gerold Diepolder (LfU BY), Charlotte Fehn (LGRB), Sunseare Gabalda (BRGM), Gregor Götzl (GBA), Andrej Lapanje (GeoZS), Fabio Carlo Molinari (RER-SGSS), Edgar Nitsch (LGRB), Robert Pamer (LfU BY), Sebastian Pfleiderer (GBA), Marco Pantaloni (ISPRA), Uta Schulz (LfU BY), Günter Sokol (LGRB), Gunther Wirsing (LGRB), Heiko Zumsprekel (LGRB)

  6. IN MY OPINION: Physics in the wider context

    NASA Astrophysics Data System (ADS)

    Morris, Andrew

    1999-11-01

    and progression opportunities for science specialists, whilst ensuring that the general public are scientifically literate. I think physics education has a serious contribution to make to all sections of society:The specialist, preparing for and progressing in a scientific/technological career. The skilled worker, analysing, understanding and innovating in any occupation. The citizen coping with increasing complexity in society. The individual trying to understanding the world into which they were born. To continue improving our educational systems and to assist each of these groups demands a grand alliance of people involved in physics education. Reflecting first on the wider context can help us choose appropriate points at which to intervene. Otherwise, educational improvement may be hampered, with valuable effort expended on positive reform actions rendered useless by constraints elsewhere in the system. How has the subject and its place in the curriculum evolved? What can be learned from previous curriculum innovations? What do public perceptions of physics tell us? The aim of the fifth Shaping the Future booklet is to encourage debate about where reform efforts should best be directed. Contributors will include Steve Adams, Michael Barnett, Sheila Carlton, John Berkeley, Martin Hollins, Marilyn Holyoake, Andrew Hunt, Roland Jackson, Jon Ogborn, Russell Stannard and Charles Thomas. A Discussion Meeting based on Physics in a wider context, at the ASE Annual Meeting, Leeds, promises to be lively. I hope you will come and express your views! If you would like to attend the meeting, to be held on 7 January 2000, and be sent a free copy of the manuscript for the 48 page booklet in advance, please contact: Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH (e-mail: 16-19project@iop.org)

  7. PREFACE: Nano- and microfluidics Nano- and microfluidics

    NASA Astrophysics Data System (ADS)

    Jacobs, Karin

    2011-05-01

    compressible fluids Kerstin Falk and Klaus Mecke Wetting, roughness and flow boundary conditions Olga I Vinogradova and Aleksey V Belyaev Molecular transport and flow past hard and soft surfaces: computer simulation of model systems F Léonforte, J Servantie, C Pastorino, and M Müller Simulations of slip flow on nanobubble-laden surfaces J Hyväluoma, C Kunert and J Harting Electrophoretic transport of biomolecules across liquid-liquid interfaces Thomas Hahn, Götz Münchow and Steffen Hardt Wetting morphologies and their transitions in grooved substrates Ralf Seemann, Martin Brinkmann, Stephan Herminghaus, Krishnacharya Khare, Bruce M Law, Sean McBride, Konstantina Kostourou, Evgeny Gurevich, Stefan Bommer, Carsten Herrmann and Dominik Michler Imbibition in mesoporous silica: rheological concepts and experiments on water and a liquid crystal Simon Gruener, and Patrick Huber Theory and simulations of water flow through carbon nanotubes: prospects and pitfalls Douwe Jan Bonthuis, Klaus F Rinne, Kerstin Falk, C Nadir Kaplan, Dominik Horinek, A Nihat Berker, Lydéric Bocquet, and Roland R Netz Structure and flow of droplets on solid surfaces P Müller-Buschbaum, D Magerl, R Hengstler, J-F Moulin, V Körstgens, A Diethert, J Perlich, S V Roth, M Burghammer, C Riekel, M Gross, F Varnik, P Uhlmann, M Stamm, J M Feldkamp and C G Schroer Stability and dynamics of droplets on patterned substrates: insights from experiments and lattice Boltzmann simulations F Varnik, M Gross, N Moradi, G Zikos, P Uhlmann, P Müller-Buschbaum, D Magerl, D Raabe, I Steinbach and M Stamm Micro-capsules in shear flow R Finken, S Kessler and U Seifert Micro-rheology on (polymer-grafted) colloids using optical tweezers C Gutsche, M M Elmahdy, K Kegler, I Semenov, T Stangner, O Otto, O Ueberschär, U F Keyser, M Krueger, M Rauscher, R Weeber, J Harting, Y W Kim, V Lobaskin, R R Netz, and F Kremer Dynamics of colloids in confined geometries L Almenar and M Rauscher Dynamics of red blood cells and vesicles in

  8. Report about the Solar Eclipse on August 11, 1999

    NASA Astrophysics Data System (ADS)

    1999-08-01

    sec) and took images in a complete automated way, allowing us to observe the eclipse by naked eye or with binoculars. To get as many images as possible during totality, we use binning 2x2 to reduce the readout time to 19 sec. Afterward, one of the best image was flat-fielded and processed with a special algorithm that modelled a fit the continuous component of the corona and then subtracted from the original image. The remaining details were enhanced by unsharp masking and added to the original image. Finally, gaussian histogram equalization was applied". Eclipse Photo by Eddy Pomaroli Second "Diamond Ring" [JPEG: 400 x 438 pix - 129k] [JPEG: 731 x 800 pix - 277k] [JPEG: 1940 x 2123 pix - 2.3M] Diamond Ring at ESO HQ (Eddy Pomaroli) "Despite the clouds, we saw the second "diamond ring" from the ESO HQ. In a sense, we were quite lucky, since the clouds were very heavy during the total phase and we might easily have missed it all!". "I used an old Minolta SRT-101 camera and a teleobjective (450 mm; f/8). The exposure was 1/125 sec on Kodak Elite 100 (pushed to 200 ASA). I had the feeling that the Sun would become visible and had the camera pointed, by good luck in the correct direction, as soon as the cloud moved away". Eclipse Photo by Roland Reiss First Partial Phase [JPEG: 400 x 330 pix - 94k] [JPEG: 800 x 660 pix - 492k] [JPEG: 3000 x 2475 pix - 4.5M] End of First Partial Phase (Roland Reiss) "I observed the eclipse from my home in Garching. The clouds kept moving and this was the last photo I was able to obtain during the first partial phase, before they blocked everything". "The photo is interesting, because it shows two more images of the eclipsed Sun, below the overexposed central part. In one of them, the remaining, narrow crescent is particularly well visible. They are caused by reflections in the camera. I used a Minolta camera and a Fuji colour slide film". Eclipse Spectra Some ESO people went a step further and obtained spectra of the Sun at the time of the

  9. Preface: Proceedings of the ESF Exploratory Workshop on Glassy Liquids under Pressure: Fundamentals and Applications (Ustroń, Poland, 10-12 October 2007) Proceedings of the ESF Exploratory Workshop on Glassy Liquids under Pressure: Fundamentals and Applications (Ustroń, Poland, 10-12 October 2007)

    NASA Astrophysics Data System (ADS)

    Drozd-Rzoska, Aleksandra; Rzoska, Sylwester J.; Tamarit, Josep Ll

    2008-06-01

    and the glass transition temperature J. Non-Cryst. Solids 353 3915 [3]Donth E 1998 The Glass Transition. Relaxation Dynamics in Liquids and Disordered Materials(Springer Series in Materials Science II vol 48) (Berlin: Springer) [4] Johari G P and Goldstein M 1971 Viscous liquids and the glass transition in aliphatic alcohols and other norigid molecules J. Chem. Phys. 55 4245 [5] Roland C M and Casalini R 2004 Viscosity crossover in 0-therphenyl and salol under high pressure Phys. Rev. Lett.92 245702 [6] Novikov V N and Sokolov A P 2003 Universality of the dynamic crossover in glass-forming liquids: A 'magic' relaxation time Phys. Rev. E 67 031507 [7] Stanley H E 1971/1987 Introduction to Critical Phenomena (New York: Oxford University Press) [8] Anisimov M A 1993 Critical Phenomena in Liquids and in Liquid Crystals (Reading: Gordon and Breach) [9] McMillan P F 2003 New materials from high pressure experiments: challenges and opportunities High Press. Res. 67 031507 [10] Craig D Q M, Royall P G, Kett V L and Hopton M L 1999 The relevance of the amorphous state to pharmaceutical dosage forms: glass drugs and freeze dried systems Int. J. Pharm. 179 179 [11] Poirier J P 2000 Introduction to the physics of the earth's interior (Cambridge: Cambridge University Press) [12] Mezzega E, Shurtenberger P, Burbridge A and Michel M 2005 Understanding food as soft materials Nature Mater. 4 729 [13] Jones R A L 2002 Soft Condensed Matter Physics (New York: Oxford University Press) [14] Angell C A 1985 Strong and fragile liquids Relaxations in Complex Systems Ngai K L and Wright (ed) (Springfield: National Technical Information Service, US Department of Commerce) 1 [15] Böhmer R, Ngai K L, Angell C A and Plazek D J 1993 Nonexponential relaxations in strong and fragile glass formers J. Chem. Phys. 99 4201 [16] Floudas G 2004 Effects of pressure on systems with intristic orientational order Prog. Polym. Sci. 29 1143 [17] Roland C M, Hensel-Bielowka S, Paluch M and Casalini R 2005

  10. Cosmic Forensics Confirms Gamma-Ray Burst And Supernova Connection

    NASA Astrophysics Data System (ADS)

    2003-03-01

    between the supernova and the gamma ray burst. The supra-nova model involves a two-step process: the first step is the collapse of the core of an extremely massive star accompanied by the ejection of the outer layers of the star. The collapsed core forms a rapidly rotating black hole surrounded by a swirling disk of matter. In the second step this black hole-disk system produces a jet of high-energy particles. Shock waves within the jet produce the burst of X-rays and gamma rays that is observed to last only a few minutes. Interaction of the jet with the ejected supernova shell produces the X-ray afterglow, which can last for days or even months. The reason for the delay between the formation of the black hole and the production of the jet is not understood. Earlier observations with Japan's ASCA, the Italian-Netherlands Beppo-SAX, and the European Space Agency's XMM-Newton satellites, as well as Chandra had given some indication of the presence of elements expected in a shell ejected by a supernova. However, the number of X-rays detected in those observations was small, and the possibility remained that the reported lines were an instrumental effect or statistical fluctuation. Since Chandra was able to observe X-ray lines from GRB 020813 for almost an entire day, the number of X-rays detected was five times larger than for previous observations. This enabled the team to make a definitive identification of the silicon and sulfur lines. Chandra observed GRB 020813 for about 77,000 seconds, approximately 21 hours after the initial burst. Other members of the research team included Herman Marshall, George Ricker, Roland Vanderspek, Peter Ford, Geoffrey Crew (MIT), and Donald Lamb (University of Chicago). The High Energy Transmission Grating Spectrometer was built by MIT. NASA's Marshall Space Flight Center in Huntsville, Ala., manages the Chandra program, and TRW, Inc., Redondo Beach, Calif., is the prime contractor for the spacecraft. The Smithsonian's Chandra X-ray Center

  11. National Geothermal Data System: Transforming the Discovery, Access, and Analytics of Data for Geothermal Exploration

    SciTech Connect

    Patten, Kim

    2013-05-01

    data are insufficient for promoting geothermal exploration. Authors of this paper are Arlene Anderson, US DOE Geothermal Technologies Office, David Blackwell, Southern Methodist University (SMU), Cathy Chickering (SMU), Toni Boyd, Oregon Institute of Technology’s GeoHeat Center, Roland Horne, Stanford University, Matthew MacKenzie, Uberity, Joe Moore, University of Utah, Duane Nickull, Uberity, Stephen Richard, Arizona Geological Survey, and Lisa Shevenell, University of Nevada, Reno. “NGDS User Centered Design: Meeting the Needs of the Geothermal Community,” discusses the user- centered design approach taken in the development of a user interface solution for the NGDS. The development process is research based, highly collaborative, and incorporates state-of-the-art practices to ensure a quality user interface for the widest and greatest utility. Authors of this paper are Harold Blackman, Boise State University, Suzanne Boyd, Anthro-Tech, Kim Patten, Arizona Geological Survey, and Sam Zheng, Siemens Corporate Research. “Fueling Innovation and Adoption by Sharing Data on the DOE Geothermal Data Repository Node on the National Geothermal Data System,” describes the motivation behind the development of the Geothermal Data Repository (GDR) and its role in the NGDS. This includes the benefits of using the GDR to share geothermal data of all types and DOE’s data submission process. Authors of this paper are Jon Weers, National Renewable Energy Laboratory and Arlene Anderson, US DOE Geothermal Technologies Office. Finally, “Developing the NGDS Adoption of CKAN for Domestic & International Data Deployment,” provides an overview of the “Node-In-A-Box” software package designed to provide data consumers with a highly functional interface to access the system, and to ease the burden on data providers who wish to publish data in the system. It is important to note that this software package constitutes a reference implementation and that the NGDS architecture

  12. Comments on Reservoir Technology, DOE PR VII, San Francisco, March 23, 1989

    SciTech Connect

    Barker, B.J.

    1989-03-21

    technology, developing the linkages of people needed to make developments have an impact on costs, and targeting those areas of greatest impact on product cost. We have seen a lot of fine DOE-sponsored work in the past which has not been effectively utilized, and I think the DOE is working to do a better job of this. The talks on Tuesday impressed me with a number of examples, I'll mention four which represent types of activities which should be encouraged. Dennis Nielson described good, basic science work on tracers, followed by relevant field testing at Dixie. This type of work is fundamental to improving our tools, and injection is a critical area of concern for both pollution control and energy recovery. Also in the area of tracers, Roland Horne described adaptation of existing technology from the transportation field. This is a particularly effective technique because borrowed methods are readily accessible to operators who lack the technical resources of the larger operators. A lot of DOE money in the past has gone into numerical modeling, including the great Reservoir Simulator Derby years ago at Stanford. Marcello Lippmann described an absolutely crucial next step which needs to be repeated to establish confidence in performance predictions. That project was the retrospective look at East Olkaria using a model which had been updated, and showed reasonable forecasting ability. Finally, the project Ernie Majer discussed, looking at microseismic signals accompanying injection, is an example of DOE/Industry cost-shared work which needs to be encouraged. This type of work will simultaneously stretch research budgets and give scientists more immediate and useful feedback from the industrial market place than we can give in annual meetings such as this. The point in these four examples is that they represent DOE research moving closer to the market. This interaction is vital to a continued DOE program which is justified by results. These trends need to be encouraged

  13. Idiopathic focal epilepsies: the "lost tribe".

    PubMed

    Pal, Deb K; Ferrie, Colin; Addis, Laura; Akiyama, Tomoyuki; Capovilla, Giuseppe; Caraballo, Roberto; de Saint-Martin, Anne; Fejerman, Natalio; Guerrini, Renzo; Hamandi, Khalid; Helbig, Ingo; Ioannides, Andreas A; Kobayashi, Katsuhiro; Lal, Dennis; Lesca, Gaetan; Muhle, Hiltrud; Neubauer, Bernd A; Pisano, Tiziana; Rudolf, Gabrielle; Seegmuller, Caroline; Shibata, Takashi; Smith, Anna; Striano, Pasquale; Strug, Lisa J; Szepetowski, Pierre; Valeta, Thalia; Yoshinaga, Harumi; Koutroumanidis, Michalis

    2016-09-01

    The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., 2010), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many "treats" for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age-related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow-wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community. Most neurologists would recognise the core syndromes of IFE to comprise: benign epilepsy of childhood with centro-temporal spikes or Rolandic epilepsy (BECTS/RE); Panayiotopoulos syndrome; and the idiopathic occipital epilepsies (Gastaut and photosensitive types). The Landau-Kleffner syndrome and the related (idiopathic) epilepsy with continuous spikes and waves in sleep (CSWS or ESES) are also often included, both as a consequence of the shared morphology of the interictal discharges and their potential evolution from core syndromes, for example, CSWS from BECTS. Atypical benign focal epilepsy of childhood also has shared electro-clinical features warranting inclusion. In addition, a number of less well-defined syndromes of IFE have been proposed, including benign childhood seizures with affective symptoms, benign childhood epilepsy with parietal spikes, benign childhood seizures with frontal or midline spikes, and benign focal seizures of adolescence. The

  14. Grain-size based sea-level reconstruction in the south Bohai Sea during the past 135 kyr

    NASA Astrophysics Data System (ADS)

    Yi, Liang; Chen, Yanping

    2013-04-01

    and sea level. Nature 324, 137-140. Charman, D.J., Roe, H.M., Roland Gehrels, W., 2002. Modern distribution of saltmarsh testate amoebae: regional variability of zonation and response to environmental variables. Journal of Quaternary Science 17, 387-409. Horton, B.P., 1997. Quantification of the indicative meaning of a range of Holocene sea-level index points from the western North Sea, Department of Geography. University of Durham, Durham City, UK, p. 509. Horton, B.P., Corbett, R., Culver, S.J., Edwards, R.J., Hillier, C., 2006. Modern saltmarsh diatom distributions of the Outer Banks, North Carolina, and the development of a transfer function for high resolution reconstructions of sea level. Estuarine, Coastal and Shelf Science 69, 381-394. IOCAS (Institute of Oceanology, Chinese Academy of Sciences), 1985. Bohai Sea Geology. Science Press, Beijing, China. Madsen, A.T., Murray, A.S., Andersen, T.J., Pejrup, M., 2007. Temporal changes of accretion rates on an estuarine salt marsh during the late Holocene -Reflection of local sea level changes? The Wadden Sea, Denmark. Marine Geology 242, 221-233. Mauz, B., Hassler, U., 2000. Luminescence chronology of Late Pleistocene raised beaches in southern Italy: new data of relative sea-level changes. Marine Geology 170, 187-203. Yi, L., Yu, H.J., Ortiz, J.D., Xu, X.Y., Qiang, X.K., Huang, H.J., Shi, X., Deng, C.L., 2012. A reconstruction of late Pleistocene relative sea level in the south Bohai Sea, China, based on sediment grain-size analysis. Sedimentary Geology 281, 88-100. Zong, Y., Shennan, I., Combellick, R.A., Hamilton, S.L., Rutherford, M.M., 2003. Microfossil evidence for land movements associated with the AD 1964 Alaska earthquake. The Holocene 13, 7-20.

  15. Competitive spirit

    NASA Astrophysics Data System (ADS)

    2000-01-01

    been published previously. Any kind of reference may be consulted; textbooks and journal articles can be cited. The problems can be downloaded from the webpage of the Ortvay contest (mafihe.elte.hu/ortvay ) in Hungarian and English; on preliminary request the problems can be sent via e-mail. If an institute is represented by several contestants, then a teacher or student acting as local organizer collects the solutions and posts them to the referees. Solutions can be sent by mail, fax or e-mail to the address given on the webpage. The contest is evaluated separately for each university year and the referees reserve the right to withhold or to divide some prizes. Beyond the money prizes for the first, second and third places, honourable mentions and special prizes for outstanding solutions of individual problems can be awarded. The sponsors of the contest are the Students' Foundation of the Faculty of Sciences of Eötvös University and the Roland Eötvös Physical Society. The results are announced in December and the organizers are hoping for even more participants in future contests. Among the winners of the European Union Young Scientists competition which took place in Thessaloniki, Greece in September was Sarah Flannery from Ireland. Sarah had used advanced mathematics to compare two cryptographic systems and proved that a new system for encrypting information on the Internet is as secure and considerably faster than the one currently in use. Three students from Iceland also gained a prize for their work on a distant cluster of hundreds of galaxies, demonstrating the capacities of modern data processing tools and the Internet in the project. The winning entries were selected from 57 projects presented from over 30 countries, and the aim of the contest was to encourage and highlight young people's interest in science by inviting them to play a part in actual research projects. Some of the winners will be able to work on projects at the Joint Research Centre

  16. Seasonal and spatial contrasts of sedimentary organic carbon in floodplain lakes of the central Amazon basin.

    NASA Astrophysics Data System (ADS)

    Sobrinho, Rodrigo; Kim, Jung-Hyun; Abril, Gwenaël; Zell, Claudia; Moreira-Turcq, Patricia; Mortillaro, Jean-Michel; Meziane, Tarik; Damsté, Jaap; Bernardes, Marcelo

    2014-05-01

    .e. from upstream to downstream. We also identify the OC contribution from the seasonally flooded forests, i.e. temporary wetlands as the most important source of sedimentary OC in floodplain lakes. Accordingly, we attribute temporal and spatial difference in sedimentary OC composition to the hydrological connectivity between the Amazon River and its floodplain lakes and thus between the surrounding forests and the floodplain lakes. References: Abril, G., J.-M.Martinez, Artigas, L.F., Moreira-Turcq, P., Benedetti, M.P., Vidal, L., Meziane, T., Kim, J.-H., Bernardes, M.C., Savoye, N., Deborde, J., Albéric, P., Souza, M.F.L., Souza, E.L., Roland, F. Amazon River carbon dioxide outgassing fuelled by wetlands. Nature accepted (2013). Battin, T.J., Luyssaert, S., Kaplan, L.A., Aufdenkampe, A.K., Richter, A., Tranvik, L.J., 2009. The boundless carbon cycle. Nature Geoscience 2, 598 - 600 (2009). Cole, J.J., Prairie, Y.T., Caraco, N.F., McDowell, W.H., Tranvik, L.J., Striegl, R.G., Duarte, C.M., Kortelainen, P., Downing, J.A., Middelburg, J.J., Melack, J. Plumbing the Global Carbon Cycle: Integrating Inland Waters into the Terrestrial Carbon Budget. Ecosystems 10, 171 - 184 (2007). Downing, J. A. Global limnology: up-scaling aquatic services and processes to planet Earth. Verh Internat Verein Limnol 30, 1149.-1166 (2009). Einsele, G., Yan, J., Hinderer, M. Atmospheric carbon burial in modern lake basins and its significance for the global carbon budget. Global and Planetary Change 30, 167 - 195 (2001). Hedges, J.I., Ertel, J.R. Characterization of Lignin by Gas Capillary Chromatography of Cupric Oxide Oxidation Products. Analitical Chemistry 54, 174-178 (1982). Hopmans, E.C., Weijers, J.W.H., Schefu, E., Herfort, L., Damste, J.S.S., Schouten, S.,. A novel proxy for terrestrial organic matter in sediments based on branched and isoprenoid tetraether lipids. Earth and Planetary Science Letters 224, 107 - 116 (2004). Martinelli, L.A., Victoria, R.L., Camargo, P.B.d., Piccolo, M

  17. European Plate Observing System - the Arctic dimension and the Nordic collaboration

    NASA Astrophysics Data System (ADS)

    Atakan, K.; Heikkinen, P.; Juhlin, C.; Thybo, H.; Vogfjord, K.

    2012-04-01

    Dehls (NGU), Øystein Nordgulen (NGU), Roland Roberts (UU), Reynir Bødvarsson (UU), Ólafur Guðmundsson (UU), Steinunn Jacobsdottir (IMO), Freysteinn Sigmundsson (IES), Benedikt Halldórsson (EERC), Gudmundur Valsson (LMI), Irina Artemieva (KU), Peter Voss (GEUS), Trine Dahl-Jensen (GEUS), Tine B. Larsen (GEUS), Jens Jørgen Møller (GEUS), Martin Hansen (GEUS), Jørgen Tulstrup (GEUS), Johnny Fredericia (GEUS), Niels Andersen (DTU-Space), Jurgen Matzka (DTU-Space), Shfaqat Abbas Khan (DTU-Space), Niels Balling (AU), Markku Poutanen (FGI), Elena Kozlovskaya (SGO).

  18. LHC Nobel Symposium Proceedings

    NASA Astrophysics Data System (ADS)

    Ekelöf, Tord

    2013-12-01

    puzzlement. The apparent absence of hints in the LHC experimental data of new phenomena that could relate to dark matter, dark energy, the dominance of matter over antimatter in the Universe, the unification of the strong and the electroweak interactions and their further unification with gravity left the Symposium with no guidance as to how to answer the question: what next? And in experimental fundamental science it is not the confirmation of already established theories that thrills the most; it is the appearance of the unexpected that creates the greatest excitement. However, the LHC is only at the beginning of its voyage into the uncharted territories of higher energies and smaller dimensions that it was built for, so the possibilities for unexpected discoveries are only starting to be explored. The LHC will start up again in 2015 with nearly twice its previous energy and with increased luminosity—new discoveries might then appear sooner than we even dare hope for! The LHC Nobel Symposium was attended by about 60 invited participants and lasted four days. The program was divided into seven sessions; QCD and Heavy Ion Physics, B Physics, Electroweak Physics, The Higgs Boson, Connections to Neutrino Physics and Astroparticle Physics, Beyond the Standard Model and Forward Look. There were 27 plenary invited talks given by participants, each followed by lively discussions. All but one of the speakers have submitted write-ups of their talks for these proceedings. We are hopeful that the remaining talk will be published in a forthcoming issue of Physica Scripta . I am gratified that Professor Roland Allen has agreed to write a paper on the essence of the Higgs boson discovery to be published in Physica Scripta , intended for undergraduate students and educated physicists, regardless of their field of research. I wish to express my deep gratitude to all Speakers and Participants in the Symposium, to the Members of the Local and International Organizing Committees, to the

  19. PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

    NASA Astrophysics Data System (ADS)

    Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

    2010-04-01

    . The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

  20. PREFACE: The Eighth Liquid Matter Conference The Eighth Liquid Matter Conference

    NASA Astrophysics Data System (ADS)

    Dellago, Christoph; Kahl, Gerhard; Likos, Christos N.

    2012-07-01

    Daoulas, Victor Rühle and Kurt Kremer Smectic shellsTeresa Lopez-Leon, Alberto Fernandez-Nieves, Maurizio Nobili and Christophe Blanc Intrinsic profiles and the structure of liquid surfacesP Tarazona, E Chacón and F Bresme Competing ordered structures formed by particles with a regular tetrahedral patch decorationGünther Doppelbauer, Eva G Noya, Emanuela Bianchi and Gerhard Kahl Heterogeneous crystallization in colloids and complex plasmas: the role of binary mobilitiesH Löwen, E Allahyarov, A Ivlev and G E Morfill Isotope effects in water as investigated by neutron diffraction and path integral molecular dynamicsAnita Zeidler, Philip S Salmon, Henry E Fischer, Jörg C Neuefeind, J Mike Simonson and Thomas E Markland Confined cubic blue phases under shearO Henrich, K Stratford, D Marenduzzo, P V Coveney and M E Cates Depletion-induced biaxial nematic states of boardlike particlesS Belli, M Dijkstra and R van Roij Active Brownian motion tunable by lightIvo Buttinoni, Giovanni Volpe, Felix Kümmel, Giorgio Volpe and Clemens Bechinger Structure and stability of charged clustersMark A Miller, David A Bonhommeau, Christopher J Heard, Yuyoung Shin, Riccardo Spezia and Marie-Pierre Gaigeot Non-equilibrium relaxation and tumbling times of polymers in semidilute solutionChien-Cheng Huang, Gerhard Gompper and Roland G Winkler Thermophoresis of colloids by mesoscale simulationsDaniel Lüsebrink, Mingcheng Yang and Marisol Ripoll Computing the local pressure in molecular dynamics simulationsThomas W Lion and Rosalind J Allen Gradient-driven fluctuations in microgravityA Vailati, R Cerbino, S Mazzoni, M Giglio, C J Takacs and D S Cannell

  1. The Eighth Liquid Matter Conference.

    PubMed

    Dellago, Christoph; Kahl, Gerhard; Likos, Christos N

    2012-07-18

    Daoulas, Victor Rühle and Kurt Kremer Smectic shellsTeresa Lopez-Leon, Alberto Fernandez-Nieves, Maurizio Nobili and Christophe Blanc Intrinsic profiles and the structure of liquid surfacesP Tarazona, E Chacón and F Bresme Competing ordered structures formed by particles with a regular tetrahedral patch decorationGünther Doppelbauer, Eva G Noya, Emanuela Bianchi and Gerhard Kahl Heterogeneous crystallization in colloids and complex plasmas: the role of binary mobilitiesH Löwen, E Allahyarov, A Ivlev and G E Morfill Isotope effects in water as investigated by neutron diffraction and path integral molecular dynamicsAnita Zeidler, Philip S Salmon, Henry E Fischer, Jörg C Neuefeind, J Mike Simonson and Thomas E Markland Confined cubic blue phases under shearO Henrich, K Stratford, D Marenduzzo, P V Coveney and M E Cates Depletion-induced biaxial nematic states of boardlike particlesS Belli, M Dijkstra and R van Roij Active Brownian motion tunable by lightIvo Buttinoni, Giovanni Volpe, Felix Kümmel, Giorgio Volpe and Clemens Bechinger Structure and stability of charged clustersMark A Miller, David A Bonhommeau, Christopher J Heard, Yuyoung Shin, Riccardo Spezia and Marie-Pierre Gaigeot Non-equilibrium relaxation and tumbling times of polymers in semidilute solutionChien-Cheng Huang, Gerhard Gompper and Roland G Winkler Thermophoresis of colloids by mesoscale simulationsDaniel Lüsebrink, Mingcheng Yang and Marisol Ripoll Computing the local pressure in molecular dynamics simulationsThomas W Lion and Rosalind J Allen Gradient-driven fluctuations in microgravityA Vailati, R Cerbino, S Mazzoni, M Giglio, C J Takacs and D S Cannell.

  2. Permanent or transitory effects on neurocognitive components of the CNV complex induced by brain dysfunctions, lesions and ablations in humans.

    PubMed

    Zappoli, Roberto

    2003-05-01

    selected patients submitted to complete ablation of the damaged cortical areas, with uni- or bilateral lesions restricted to the prefrontal or associative parieto-temporal areas. We have always used the standard CNV paradigm (S1-S2 motor-response) which evokes a complex of neurocognitive potentials, including the P300 from S1, which are well-known, since they are certainly among the most studied ERPs in the various ages and races of normal subjects, psychiatric patients and subjects with different brain diseases. The most important results have been, (1) In normal subjects the MRI and the latency differences of CNV component measurements along the bidirectional pathways functionally interconnecting ipsilateral distant associative cortical areas (e.g. the arcuate-superior longitudinal complex bundle) were accounted for by the transcortical conduction time, which varies in our scalp recordings from 1 cm/0.74 to 1.28 ms ( approximately 9.8 m/s). (2) Constantly, no true auditory S1-elicited N1a, b, c, P2, N2, P300 components or CNV slow waves (O- and E-wave) were recordable over the whole of the ablated cortical areas, but only clearly identifiable volume-conducted EP/ERPs generated in other hemispheric structures. (3) The post-S1 ERP/CNV complexes on the intact hemisphere were found to be within the normal limits. (4) Effects of severe disruption on the S1 ERP/CNV complexes evocable on the site and on remote ipsilateral apparently normal anatomo-functionally interconnected brain regions were observed in 5 patients, 4 of whom had extensive frontocortical ablations. In two of the latter the distant disruptive action on the CNV components over the neuroradiologically normal ipsilateral two-way connected post-rolandic sensory and association areas was seen to be partially reversible, showing aspects of a probable slowly evolving diaschisis-like effect. Similar deactivation of some ERP components was observed in reverse on the ipsilateral dorsolateral frontocortical region in the

  3. Predictive engineering tools for injection-molded long-carbon-fiber thermoplastic composites - FY 2015 third quarterly report

    SciTech Connect

    Nguyen, Ba Nghiep; Fifield, Leonard S.; Mori, Steven; Gandhi, Umesh N.; Wang, Jin; Costa, Franco; Wollan, Eric J.; Tucker, III, Charles L.

    2015-07-01

    During the third quarter of FY 2015, the following technical progress has been made toward project milestones: 1) Magna oversaw the tool build and prepared the molding plan for the complex part of Phase II. 2) PlastiComp hosted a visit by Magna and Toyota on April 23rd to finalize the molding scope and schedule. The plan for molding trials including selection of molding parameters for both LFT and D-LFT for the U-shape complex part was established. 3) Toyota shipped the U-shape complex part tool to Magna on May 28th, 2015. 4) Plasticomp provided 30wt% LCF/PP and 30wt% LCF/PA66 compounded pellets to Magna for molding the complex part. 5) Magna performed preliminary molding trials on June 2nd, 2015 to validate wall thickness, fill profile, tool temperature and shot size requirements for the complex part. 6) Magna performed the first complex part run on June 16th and 17th, 2015 at Magna’s Composite Centre of Excellence in Concord, ON, Canada. Dale Roland of Plasticomp, and Umesh Gandhi of Toyota also attended the molding. 7) Magna discussed and finalized the plan with PNNL and the team for cutting samples from molded parts at selected locations for fiber orientation and length measurements. 8) Magna provided the computer-aided design (CAD) files of the complex parts with and without ribs to PNNL and Autodesk to build the corresponding ASMI models for injection molding simulations. Magna also provided the actual parameters used. 9) Plasticomp’s provided knowledge and experience of molding LCF materials essential to the successful molding of the parts including optimization of fill speed, tool temperatures, and plasticizing conditions for the 30wt% LCF/PP and 30wt% LCF/PA66 materials in both rib and non-rib versions. 10) Magna molded additional parts for evaluation of mechanical property testing including torsional stiffness on June 29th and 30th, 2015 at Magna’s Composite Center of Excellence. 11) Toyota began preparation for the torsion test of the specimens

  4. Chiropractic clinical practice guideline: evidence-based treatment of adult neck pain not due to whiplash

    PubMed Central

    Anderson-Peacock, Elizabeth; Blouin, Jean-Sébastien; Bryans, Roland; Danis, Normand; Furlan, Andrea; Marcoux, Henri; Potter, Brock; Ruegg, Rick; Gross Stein, Janice; White, Eleanor

    2005-01-01

    treatment options or referral to the appropriate health services. For adverse events associated with a treatment modality, but not a known or observable risk factor, there was evidence to recommend heightened vigilance when a relevant treatment is planned or administered. For adverse events associated with a treatment modality and predicted by an observable risk factor, there was evidence to recommend absolute contraindications, and requirements for treatment modality modification or caution to minimize harm and maximize benefit. For managing the theoretic risk of dissection, there was evidence to recommend a systematic risk-management approach. For managing the theoretic risk of stroke, there was support to recommend minimal rotation in administering any modality of upper-cervical spine treatment, and to recommend caution in treating a patient with hyperhomocysteinemia, although the evidence was especially ambiguous in both of these areas. Research recommendations addressed the poor caliber of many of the studies; the GDC concluded that the scientific base for chiropractic cervical treatment of neck pain was not of sufficient quality or scope to “cover” current chiropractic practice comprehensively, although this should not suggest other disciplines are more evidence-based. VALIDATION This guideline was authored by the 10 members of the GDC (Elizabeth Anderson-Peacock, Jean-Sébastien Blouin, Roland Bryans, Normand Danis, Andrea Furlan, Henri Marcoux, Brock Potter, Rick Ruegg, Janice Gross Stein, Eleanor White) based on the work of 3 literature search teams and an evidence extraction team, and in light of feedback from a commentator (Donald R Murphy), a 5-person review panel (Robert R Burton, Andrea Furlan, Richard Roy, Steven Silk, Roy Till), a 6-person Task Force (Grayden Bridge, H James Duncan, Wanda Lee MacPhee, Bruce Squires, Greg Stewart, Dean Wright), and 2 national profession-wide critiques of complete drafts. Two professional editors with extensive guidelines

  5. Contribution of seismic processing to put up the scaffolding for the 3-dimensional study of deep sedimentary basins: the fundaments of trans-national 3D modelling in the project GeoMol

    NASA Astrophysics Data System (ADS)

    Capar, Laure

    2013-04-01

    European Territorial Cooperation 2007-2013. The project integrates partners from Austria, France, Germany, Italy, Slovenia and Switzerland and runs from September 2012 to June 2015. Further information on www.geomol.eu The GeoMol seismic interpretation team: Roland Baumberger (swisstopo), Agnès BRENOT (BRGM), Alessandro CAGNONI (RLB), Renaud COUËFFE (BRGM), Gabriel COURRIOUX (BRGM), Chiara D'Ambrogi (ISPRA), Chrystel Dezayes (BRGM), Charlotte Fehn (LGRB), Sunseare GABALDA (BRGM), Gregor Götzl (GBA), Andrej Lapanje (GeoZS), Stéphane MARC (BRGM), Alberto MARTINI (RER-SGSS), Fabio Carlo Molinari (RER-SGSS), Edgar Nitsch (LGRB), Robert Pamer (LfU BY), Marco PANTALONI (ISPRA), Sebastian Pfleiderer (GBA), Andrea PICCIN (RLB), (Nils Oesterling (swisstopo), Isabel Rupf (LGRB), Uta Schulz (LfU BY), Yves SIMEON (BRGM), Günter SÖKOL (LGRB), Heiko Zumsprekel (LGRB)

  6. Sixth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.

    1980-12-18

    researchers, engineers and managers involved in geothermal reservoir study and development and the provision of a forum for the prompt and open reporting of progress and for the exchange of ideas, continue to be met . Active discussion by the majority of the participants is apparent both in and outside the workshop arena. The Workshop Proceedings now contain some of the most highly cited geothermal literature. Unfortunately, the popularity of the Workshop for the presentation and exchange of ideas does have some less welcome side effects. The major one is the developing necessity for a limitation of the number of papers that are actually presented. We will continue to include all offered papers in the Summaries and Proceedings. As in the recent past, this sixth Workshop was supported by a grant from the Department of Energy. This grant is now made directly to Stanford as part of the support for the Stanford Geothermal Program (Contract No. DE-AT03-80SF11459). We are certain that all participants join us in our appreciation of this continuing support. Thanks are also due to all those individuals who helped in so many ways: The members of the program committee who had to work so hard to keep the program to a manageable size - George Frye (Aminoil USA), Paul G. Atkinson (Union Oil Company). Michael L. Sorey (U.S.G.S.), Frank G. Miller (Stanford Geothermal Program), and Roland N. Horne (Stanford Geothermal Program). The session chairmen who contributed so much to the organization and operation of the technical sessions - George Frye (Aminoil USA), Phillip H. Messer (Union Oil Company), Leland L. Mink (Department of Energy), Manuel Nathenson (U.S.G.S.), Gunnar Bodvarsson (Oregon State University), Mohindar S. Gulati (Union Oil Company), George F. Pinder (Princeton University), Paul A. Witherspoon (Lawrence Berkeley Laboratory), Frank G. Miller (Stanford Geothermal Program) and Michael J. O'Sullivan (Lawrence Berkeley Laboratory). The many people who assisted behind the scenes

  7. 10 years of mapping the icy saturnian satellites

    NASA Astrophysics Data System (ADS)

    Roatsch, Thomas; Kersten, Elke; Matz, Klaus-Dieter; Porco, Carolyn

    2014-05-01

    synoptic map for making planet-wide maps on a single sheet was used for Phoebe [2]. • A quadrangle scheme with 15 tiles for Mercury-sized bodies and high-resolution imaging was used for Enceladus, Tethys, Dione, and Rhea. • A quadrangle scheme with 3 tiles, a subdivision of the synoptic map was used for Mimas and Iapetus. The individual maps and tiles were extracted from global mosaics and reprojected into the defined map projections. We added resolution maps and index maps for every individual tile of the atlas, showing the image resolution, the image numbers and the location of the images for every map, respectively. The entire atlases are available to the public through the Imaging Team's website: http://ciclops.org/maps. The map tiles are also archived as standard products in the Planetary Data System (PDS): http://pds.jpl.nasa.gov/. Nomenclature: The nomenclature proposed by the Cassini-ISS team was approved by the IAU (http://planetarynames.wr.usgs.gov/). By international agreement, the features must be named after people or locations in • "Le Morte d'Arthur" for Mimas • "The Thousand Nights and a Night" for Enceladus • "The Odyssey of Homer" for Tethys • "The Aeneid of Virgil" for Dione • Creation myths (with Asian emphasis) for Rhea • "The Song of Roland" for Iapetus • "The Argonautica" for Phoebe Future work: The Cassini Equinox mission ended in 2010. Cassini is now operating in the Solstice mission hopefully until September 2017. Several additional close satellite flybys are scheduled for this time frame e.g. for Enceladus in October 2015 and for Mimas in January 2017. These upcoming flybys will help to replace the low-resolution parts of these atlases with higher resolu-tion images. The northern polar regions will be illumi-nated during the extended mission providing an oppor-tunity to obtain high-resolution Cassini coverage of high northern latitudes. References: [1] Porco et al., 2004, Cassini imaging science: instrument characteristics and

  8. Editorial: Current status and perspective on drug targets in tubercle bacilli and drug design of antituberculous agents based on structure-activity relationship.

    PubMed

    Tomioka, Haruaki

    2014-01-01

    promoting the elucidation of the molecular structures of drug targets in MTB, and are consequently markedly useful for the design of new, promising antituberculous drugs using QSAR techniques. In this issue, we review the following areas. Firstly, Dr. Li M. Fu reviews the perspective that combines machine learning and genomics for drug discovery in tuberculosis, in relation to the problem that the exhaustive search for useful drug targets over the entire MTB genome would not be as productive as expected in practice [1]. Secondly, the review article by Drs. R. S. Chauhan. S. K. Chanumolu, C. Rout, and R. Shrivastava focuses on analysis of the current state of MTB genomic resources, host-pathogen interaction studies in the context of mycobacterial persistence, and drug target discovery based on the utilization of computational tools and metabolic network analyses [2]. Thirdly, Drs. Daria Bottai, Agnese Serafini, Alessandro Cascioferro, Roland Brosch, and Riccardo Manganelli review the current knowledge on MTB T7SS/ESX secretion systems and their impact on MTB physiology and virulence, and the possible approaches to develop T7SS/ESX inhibitors [3]. Fourthly, Drs. E. Jeffrey North, Mary Jackson, and Richard E. Lee review and analyze new and emerging inhibitors of the mycolic acid biosynthetic pathway, including mycobacterial enzymes for fatty acid synthesis, mycolic acid-modifying enzymes, fatty acid-activating and -condensing enzymes, transporters, and transferases, that have been discovered in the post-genomic era of tuberculosis drug discovery [4]. Fifthly, Drs. Katarina Mikusova, Vadim Makarov, and Joao Neres review the mycobacterial enzyme DprE1, which catalyzes a unique epimerization reaction in the biosynthesis of decaprenylphosphoryl arabinose, a single donor of the arabinosyl residue for the build-up of arabinans, one of the mycobacterial cell wall components, as an important drug target especially for the development of benzothiazinones [5]. Sixthly, I review the

  9. PREFACE: Introduction to the proceedings of Dynamics Days South America 2010

    NASA Astrophysics Data System (ADS)

    Macau, Elbert E. N.; Pereira, Tiago; Prado, Antonio F. B. A.; Turci, Luiz F. R.; Winter, Othon C.

    2011-03-01

    number of attendees ever. Finally, we would like to express our gratitude to all the participants for their presentations, discussions, and remarkable interactions with one another. The tireless work undertaken by all the members of the International Advisory Committee and the Organizing Committee must also be recognized. We also wish to express our deep appreciation for the Scientific Societies and Research Support Agencies which supported the conference and provided all the resources which were necessary to make this idea of a South American Dynamics Days come true. Elbert E N Macau, Tiago Pereira, Antonio F B A Prado, Luiz F R Turci, and Othon C WinterEditors Conference photograph Conference photograph Conference photograph Conference photograph International Advisory Committee Adilson E MotterNorthwestern UniversityEvanston - IL - USA Alfredo OzorioCentro Brasileiro de Pesquisas FísicasRio de Janeiro - RJ - Brazil Celso Grebogi (Chair)University of AberdeenAberdeen - UK Ed OttUniversity of MarylandCollege Park - MD - USA Epaminondas Rosa JrIllinois State UniversityNormal - IL - USA Hans Ingo WeberPontifícia Universidade CatólicaRio de Janeiro - RJ - Brazil Holger KantzMax Planck Institute for the Physics of Complex SystemsDresden - Germany Jason Gallas (Co-chair)Universidade Federal do Rio Grande do SulPorto Alegre - RS - Brazil José Roberto Rios LeiteUniv. Federal de PernanbucoRecife - PE - Brazil Jürgen KurthsPotsdam Institute for climate Impact ResearchHumboldt University, Berlin - Germany Kenneth ShowalterWest Virginia UniversityMorgantown - WV - USA Lou PecoraNaval Research LabWashington - DC - USA Luis Antonio AguirreUniversidade Federal de Minas GeraisBelo Horizonte - MG - Brazil Marcelo VianaIMPA - Instituto Nacional de Matemática Pura e AplicadaRio de Janeiro - RJ - Brazil Miguel A F SanjuánUniversidad Rey Juan CarlosMadrid - Spain Paulo Roberto de Souza MendesPontifícia Universidade CatólicaRio de Janeiro - RJ - Brazil Roland KorbeleUniversidade de

  10. ESA's high-energy observatories spot doughnut-shaped cloud with a black-hole filling

    NASA Astrophysics Data System (ADS)

    2004-07-01

    -energy X-rays seen by XMM-Newton appear to come from a diffuse emission, far away from the black hole, the higher-energy X-rays detected by Integral are directly related to the black hole activity. The team could infer the doughnut’s structure and its distance from the black hole by virtue of light that was either reflected or completely absorbed. The torus itself appears to be several hundred light years from the black hole, although the observation could not gauge its diameter, from inside to outside. The result marks the clearest observation of an obscured black hole in X-ray and gamma-ray `colours’, a span of energy nearly a million times wider than the window of visible light, from red to violet. Multi-wavelength studies are increasingly important to understanding black holes, as already demonstrated earlier this year. In May 2004, the European project known as the Astrophysical Virtual Observatory, in which ESA plays a major role, found 30 supermassive black holes that had previously escaped detection behind masking dust clouds. Note for editors This result will appear on The Astrophysical Journal. Besides Volker Beckmann, the author list includes Neil Gehrels, Pascal Favre, Roland Walter, Thierry Courvoisier, Pierre-Olivier Petrucci and Julien Malzac. For more information about the Astrophysical Virtual Observatory programme and how it has allowed European scientists to discover a number of previously hidden black holes, see: http://www.spacetelescope.org/news/html/heic0409.html More about Integral The International Gamma Ray Astrophysics Laboratory (Integral) is the first space observatory that can simultaneously observe celestial objects in gamma rays, X-rays and visible light. Integral was launched on a Russian Proton rocket on 17 October 2002 into a highly elliptical orbit around Earth. Its principal targets include regions of the galaxy where chemical elements are being produced and compact objects, such as black holes. More information on Integral can be

  11. Enacs Survey of Southern Galaxies Indicates Open Universe

    NASA Astrophysics Data System (ADS)

    1996-02-01

    first time. This may imply that the formation of at least a good fraction of the nearby, rich clusters is still going on. If the mean density of the Universe is indeed much smaller than the critical density, as indicated by the cluster masses determined during this survey, then this is a quite unexpected result. One explanation may be that many clusters have only started to form fairly recently. Notes: [1] The team is headed by Peter Katgert (Leiden Observatory, The Netherlands) and Alain Mazure (Laboratoire d'Astronomie Spatiale, Marseille, France); other members are Andrea Biviano and Roland den Hartog (Leiden Observatory, The Netherlands), Pierre Dubath (Observatoire de Geneve, Switzerland), Eric Escalera (SISSA, Trieste, Italy), Paola Focardi (Bologna University, Italy), Daniel Gerbal (Institut d'Astrophysique, Paris, France), Guilano Giuricin (SISSA, Trieste, Italy), Bernard Jones (Theoretical Astrophysics Centre, Copenhagen, Denmark), Olivier Le Fevre (Meudon Observatory, Paris, France), Mariano Moles and Jaime Perea (Astrophysics Institute of Andalucia, Granada, Spain), and George Rhee (University of Nevada, Las Vegas, U.S.A.). [2] The detailed results will soon be published in two comprehensive articles to appear in the European journal Astronomy & Astrophysics. [3] This Press Release is accompanied by ESO Press Photo 07/96, (click here to get the image [GIF,45k] and caption ) showing one of the rich clusters, as observed with the ESO 1-metre Schmidt telescope. [4] The masses of the planets in the solar system are determined in a similar way from the motions of their moons. The faster the moon moves around the planet at a given distance, the heavier is the planet.

  12. Balloon Kyphoplasty

    PubMed Central

    2004-01-01

    balloon kyphoplasty for patients with multiple myeloma or metastatic disease. In another study, the researchers reported complete height restoration in 9% of patients, a mean 56% height restoration in 60% of patients, and no appreciable height restoration in 31% of the patients who received balloon kyphoplasty. Kyphosis correction: Four studies that assessed Cobb angle before and after balloon kyphoplasty in patients with osteoporosis found a significant reduction in degree of kyphosis after the procedure. In these studies, the differences between preoperative and postoperative Cobb angles were 3.4°, 7°, 8.8°, and 9.9°. Only 1 study investigated kyphosis correction in patients with multiple myeloma or metastatic disease. The authors reported a significant improvement (5.2°) in local kyphosis. Quality of life: Four studies used the Short Form 36 (SF-36) Health Survey Questionnaire to measure the quality of life in patients with osteoporosis after they had balloon kyphoplasty. A significant improvement in most of the domains of the SF-36 (bodily pain, social functioning, vitality, physical functioning, mental health, and role functioning) was observed in 2 studies. One study found that general health declined, although not significantly, and another found that role emotional declined. Both studies that used the Oswestry Disability Index found that patients had a better quality of life after balloon kyphoplasty. In one study, this improvement was statistically significant. In another study, researchers found that quality of life after kyphoplasty improved significantly, as measured with the Roland-Morris Disability Questionnaire. Yet another study used a quality of life questionnaire and found that 62% of the patients that had balloon kyphoplasty had returned to normal activities, whereas 2 patients had reduced mobility. To measure quality of life in patients with multiple myeloma or metastatic disease, one group of researchers used the SF-36 and found significantly