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Sample records for krishnan rajeshwar rob

  1. Remembering K. S. Krishnan (1946-2014).

    PubMed

    Rikhy, Richa; Kumar, Vimlesh; Basole, Amit; Sanyal, Subhabrata

    2015-03-01

    Dr. K. S. Krishnan was on the faculty of the Division of Biological Sciences at the Tata Institute of Fundamental Research (TIFR) in Mumbai, India, and later emeritus professor at the National Center for Biological Sciences (NCBS) in Bangalore, India. His research using fruit flies has contributed richly to our understanding of synaptic function and mechanisms of anesthetic action. Dr. Krishnan passed away suddenly of a heart attack on the 24th of May, 2014. Below a few of his students fondly recall how it was to work in his group.

  2. When attempts at robbing prey turn fatal.

    PubMed

    Dejean, Alain; Corbara, Bruno; Azémar, Frédéric; Carpenter, James M

    2012-07-01

    Because group-hunting arboreal ants spread-eagle insect prey for a long time before retrieving them, these prey can be coveted by predatory flying insects. Yet, attempting to rob these prey is risky if the ant species is also an effective predator. Here, we show that trying to rob prey from Azteca andreae workers is a fatal error as 268 out of 276 potential cleptobionts (97.1 %) were captured in turn. The ant workers hunt in a group and use the "Velcro®" principle to cling firmly to the leaves of their host tree, permitting them to capture very large prey. Exceptions were one social wasp, plus some Trigona spp. workers and flies that landed directly on the prey and were able to take off immediately when attacked. We conclude that in this situation, previously captured prey attract potential cleptobionts that are captured in turn in most of the cases.

  3. When attempts at robbing prey turn fatal.

    PubMed

    Dejean, Alain; Corbara, Bruno; Azémar, Frédéric; Carpenter, James M

    2012-07-01

    Because group-hunting arboreal ants spread-eagle insect prey for a long time before retrieving them, these prey can be coveted by predatory flying insects. Yet, attempting to rob these prey is risky if the ant species is also an effective predator. Here, we show that trying to rob prey from Azteca andreae workers is a fatal error as 268 out of 276 potential cleptobionts (97.1 %) were captured in turn. The ant workers hunt in a group and use the "Velcro®" principle to cling firmly to the leaves of their host tree, permitting them to capture very large prey. Exceptions were one social wasp, plus some Trigona spp. workers and flies that landed directly on the prey and were able to take off immediately when attacked. We conclude that in this situation, previously captured prey attract potential cleptobionts that are captured in turn in most of the cases. PMID:22710934

  4. Wasps robbing food from ants: a frequent behavior?

    NASA Astrophysics Data System (ADS)

    Lapierre, Louis; Hespenheide, Henry; Dejean, Alain

    2007-12-01

    Food robbing, or cleptobiosis, has been well documented throughout the animal kingdom. For insects, intrafamilial food robbing is known among ants, but social wasps (Vespidae; Polistinae) taking food from ants has, to the best of our knowledge, never been reported. In this paper, we present two cases involving social wasps robbing food from ants associated with myrmecophytes. (1) Polybioides tabida F. (Ropalidiini) rob pieces of prey from Tetraponera aethiops Smith (Formicidae; Pseudomyrmecinae) specifically associated with Barteria fistulosa Mast. (Passifloraceae). (2) Charterginus spp. (Epiponini) rob food bodies from myrmecophytic Cecropia (Cecropiaceae) exploited by their Azteca mutualists (Formicidae; Dolichoderinae) or by opportunistic ants (that also attack cleptobiotic wasps). We note here that wasps gather food bodies (1) when ants are not yet active; (2) when ants are active, but avoiding any contact with them by flying off when attacked; and (3) through the coordinated efforts of two to five wasps, wherein one of them prevents the ants from leaving their nest, while the other wasps freely gather the food bodies. We suggest that these interactions are more common than previously thought.

  5. White Natives. "Braveheart" and "Rob Roy" as Colonial Victims.

    ERIC Educational Resources Information Center

    Beck, Bernard

    1995-01-01

    Two contemporary films, "Braveheart" and "Rob Roy," depict Scottish ethnicity from a rather narrow perspective. The positions that are sentimentally admired when attributed to white natives of Scotland are horrifying when expressed by contemporary peoples of color. These films raise interesting questions about the true nature of ethnicity. (SLD)

  6. Sugary food robbing in ants: a case of temporal cleptobiosis.

    PubMed

    Richard, Freddie-Jeanne; Dejean, Alain; Lachaud, Jean-Paul

    2004-05-01

    This study reports new information on interactions between Ectatomma tuberculatum (Ponerinae) and Crematogaster limata parabiotica (Myrmicinae). Workers of these sympatric arboreal ant species forage on the same pioneer trees. Diurnally, Ectatomma preyed on Crematogaster workers that avoided overt aggression by respecting a 'safe distance'. At night, Crematogaster initiated raids within the Ectatomma nests that they apparently left with their abdomen empty, then remained near the nest entrances where they successfully intercepted 75.2% of the returning Ectatomma foragers (N = 322). Certain intercepted workers rapidly resumed their return trip. Others (39.1%) were stopped, explored and licked during a long time by the Crematogaster. Most of them were carrying between their mandibles a droplet of liquid food that was stolen. This relationship, that appears to be a typical case of interspecific cleptobiosis, whose expression varies during the daytime, demonstrates for the first time sugary-food robbing, instead of prey robbing, in ants.

  7. A critique of Rob Lovering's criticism of the substance view.

    PubMed

    Friberg-Fernros, Henrik

    2015-03-01

    In his article, The Substance View: a critique, Rob Lovering argues that the substance view - according to which the human embryo is a person entitled to human rights - leads to such implausible implications that this view should be abandoned. In this article I respond to his criticism by arguing that either his arguments fail because the proponents of the substance view are not obligated to hold positions which may be considered absurd, or because the positions which they are assumed to be obligated to hold, are not absurd at all.

  8. A critique of Rob Lovering's criticism of the substance view.

    PubMed

    Friberg-Fernros, Henrik

    2015-03-01

    In his article, The Substance View: a critique, Rob Lovering argues that the substance view - according to which the human embryo is a person entitled to human rights - leads to such implausible implications that this view should be abandoned. In this article I respond to his criticism by arguing that either his arguments fail because the proponents of the substance view are not obligated to hold positions which may be considered absurd, or because the positions which they are assumed to be obligated to hold, are not absurd at all. PMID:24372146

  9. Spatio-temporal variation of nectar robbing in Salvia gesneriflora and its effects on nectar production and legitimate visitors.

    PubMed

    Cuevas, E; Rosas-Guerrero, V

    2016-01-01

    Nectar robbing occurs when floral visitors remove floral nectar through floral damage and usually without providing pollination in return. Even though nectar robbing may have negative, neutral or even positive effects on plant fitness, few studies have investigated temporal and spatial variation in robbing rate and their consequences, particularly in the tropics. In this study, robbing levels were estimated during 3 years in four populations of Salvia gesneriflora, a hummingbird-pollinated shrub endemic to central Mexico that is mainly robbed by birds, carpenter bees and bumblebees. The effect of robbing on nectar availability, flower longevity and on visitation rate by floral visitors was also evaluated. Our results indicate great variation in robbing levels across years and populations and a positive relationship between robbing level and flower abundance per population. Moreover, our results show that nectar availability is about eight times higher in unrobbed flowers than in robbed flowers, and that nectar robbers prefer younger flowers, although lifespan of robbed and unrobbed flowers did not differ statistically. Primary and secondary nectar robbers showed a higher visitation rate compared to legitimate visitors, and neither legitimate nor illegitimate floral visitors seem to discriminate between robbed and unrobbed flowers. These results suggest that robbers may respond to food availability and that no floral visitors apparently could differentiate between robbed and unrobbed flowers. Finally, results show that nectar robbers prefer the youngest flowers, which suggests that strong competition for access to nectar between pollinators and robbers might occur, mainly at the first stages of the flowers.

  10. Spatio-temporal variation of nectar robbing in Salvia gesneriflora and its effects on nectar production and legitimate visitors.

    PubMed

    Cuevas, E; Rosas-Guerrero, V

    2016-01-01

    Nectar robbing occurs when floral visitors remove floral nectar through floral damage and usually without providing pollination in return. Even though nectar robbing may have negative, neutral or even positive effects on plant fitness, few studies have investigated temporal and spatial variation in robbing rate and their consequences, particularly in the tropics. In this study, robbing levels were estimated during 3 years in four populations of Salvia gesneriflora, a hummingbird-pollinated shrub endemic to central Mexico that is mainly robbed by birds, carpenter bees and bumblebees. The effect of robbing on nectar availability, flower longevity and on visitation rate by floral visitors was also evaluated. Our results indicate great variation in robbing levels across years and populations and a positive relationship between robbing level and flower abundance per population. Moreover, our results show that nectar availability is about eight times higher in unrobbed flowers than in robbed flowers, and that nectar robbers prefer younger flowers, although lifespan of robbed and unrobbed flowers did not differ statistically. Primary and secondary nectar robbers showed a higher visitation rate compared to legitimate visitors, and neither legitimate nor illegitimate floral visitors seem to discriminate between robbed and unrobbed flowers. These results suggest that robbers may respond to food availability and that no floral visitors apparently could differentiate between robbed and unrobbed flowers. Finally, results show that nectar robbers prefer the youngest flowers, which suggests that strong competition for access to nectar between pollinators and robbers might occur, mainly at the first stages of the flowers. PMID:25677960

  11. Floral Nectar Guide Patterns Discourage Nectar Robbing by Bumble Bees

    PubMed Central

    Leonard, Anne S.; Brent, Joshua; Papaj, Daniel R.; Dornhaus, Anna

    2013-01-01

    Floral displays are under selection to both attract pollinators and deter antagonists. Here we show that a common floral trait, a nectar guide pattern, alters the behavior of bees that can act opportunistically as both pollinators and as antagonists. Generally, bees access nectar via the floral limb, transporting pollen through contact with the plant’s reproductive structures; however bees sometimes extract nectar from a hole in the side of the flower that they or other floral visitors create. This behavior is called “nectar robbing” because bees may acquire the nectar without transporting pollen. We asked whether the presence of a symmetric floral nectar guide pattern on artificial flowers affected bumble bees’ (Bombus impatiens) propensity to rob or access nectar “legitimately.” We discovered that nectar guides made legitimate visits more efficient for bees than robbing, and increased the relative frequency of legitimate visits, compared to flowers lacking nectar guides. This study is the first to show that beyond speeding nectar discovery, a nectar guide pattern can influence bees’ flower handling in a way that could benefit the plant. PMID:23418475

  12. Realized tolerance to nectar robbing: compensation to floral enemies in Ipomopsis aggregata

    PubMed Central

    Irwin, Rebecca E.

    2009-01-01

    Background and Aims Although the ecological and evolutionary consequences of foliar herbivory are well understood, how plants cope with floral damage is less well explored. Here the concept of tolerance, typically studied within the context of plant defence to foliar herbivores and pathogens, is extended to floral damage. Variation in tolerance to floral damage is examined, together with some of the mechanisms involved. Methods The study was conducted on Ipomopsis aggregata, which experiences floral damage and nectar removal by nectar-robbing bees. High levels of robbing can reduce seeds sired and produced by up to 50 %, an indirect effect mediated through pollinator avoidance of robbed plants. Using an experimental common garden with groups of I. aggregata, realized tolerance to robbing was measured. Realized tolerance included both genetic and environmental components of tolerance. It was hypothesized that both resource acquisition and storage traits, and traits involved in pollination would mitigate the negative effects of robbers. Key Results Groups of I. aggregata varied in their ability to tolerate nectar robbing. Realized tolerance was observed only through a component of male plant reproduction (pollen donation) and not through components of female plant reproduction. Some groups fully compensated for robbing while others under- or overcompensated. Evidence was found only for a pollination-related trait, flower production, associated with realized tolerance. Plants that produced more flowers and that had a higher inducibility of flower production following robbing were more able to compensate through male function. Conclusions Variation in realized tolerance to nectar robbing was found in I. aggregata, but only through an estimate of male reproduction, and traits associated with pollination may confer realized tolerance to robbing. By linking concepts and techniques from studies of plant–pollinator and plant–herbivore interactions, this work provides

  13. Impact of Striped-Squirrel Nectar-Robbing Behaviour on Gender Fitness in Alpinia roxburghii Sweet (Zingiberaceae).

    PubMed

    Deng, Xiaobao; Mohandass, Dharmalingam; Katabuchi, Masatoshi; Hughes, Alice C; Roubik, David W

    2015-01-01

    Nectar-robbing has the potential to strongly affect male and female reproductive fitness of plants. One example of nectar theft is that shown by striped-squirrels (Tamiops swinhoei) on a number of ginger species, including Alpinia roxburghii and A. kwangsiensis (Zingiberaceae). In this study, we used a fluorescent dye as a pollen analogue, and measured fruit and seed output, to test the effect of squirrel nectar-robbing on A. roxburghii reproductive fitness. Pollen transfer between robbed and unrobbed flowers was assessed by comparing 60 randomly established plots containing robbed and unrobbed flowers. The frequency of squirrel robbing visits and broken styles were recorded from a number of flowers for five consecutive days. Two bee species (Bombus eximius and Apis cerana), were the primary pollinators, and their visitation frequency was recorded for six consecutive days. The results showed that fluorescent powder from unrobbed flowers was dispersed further, and to a greater number of flowers than that placed on robbed flowers. Additionally, robbing flowers caused significant damage to reproductive organs, resulting in lower fruit and seed sets in robbed than in unrobbed flowers and influencing both male and female fitness. The frequency of the primary pollinator visits (B. eximius) was significantly higher for unrobbed plants than for robbed plants. The present study clearly shows the negative impact of squirrel robbing on A. roxburghii male reproductive fitness and neutral impact on female reproductive fitness. PMID:26689684

  14. Impact of Striped-Squirrel Nectar-Robbing Behaviour on Gender Fitness in Alpinia roxburghii Sweet (Zingiberaceae)

    PubMed Central

    Deng, Xiaobao; Mohandass, Dharmalingam; Katabuchi, Masatoshi; Hughes, Alice C.; Roubik, David W.

    2015-01-01

    Nectar-robbing has the potential to strongly affect male and female reproductive fitness of plants. One example of nectar theft is that shown by striped-squirrels (Tamiops swinhoei) on a number of ginger species, including Alpinia roxburghii and A. kwangsiensis (Zingiberaceae). In this study, we used a fluorescent dye as a pollen analogue, and measured fruit and seed output, to test the effect of squirrel nectar-robbing on A. roxburghii reproductive fitness. Pollen transfer between robbed and unrobbed flowers was assessed by comparing 60 randomly established plots containing robbed and unrobbed flowers. The frequency of squirrel robbing visits and broken styles were recorded from a number of flowers for five consecutive days. Two bee species (Bombus eximius and Apis cerana), were the primary pollinators, and their visitation frequency was recorded for six consecutive days. The results showed that fluorescent powder from unrobbed flowers was dispersed further, and to a greater number of flowers than that placed on robbed flowers. Additionally, robbing flowers caused significant damage to reproductive organs, resulting in lower fruit and seed sets in robbed than in unrobbed flowers and influencing both male and female fitness. The frequency of the primary pollinator visits (B. eximius) was significantly higher for unrobbed plants than for robbed plants. The present study clearly shows the negative impact of squirrel robbing on A. roxburghii male reproductive fitness and neutral impact on female reproductive fitness. PMID:26689684

  15. Impact of Striped-Squirrel Nectar-Robbing Behaviour on Gender Fitness in Alpinia roxburghii Sweet (Zingiberaceae).

    PubMed

    Deng, Xiaobao; Mohandass, Dharmalingam; Katabuchi, Masatoshi; Hughes, Alice C; Roubik, David W

    2015-01-01

    Nectar-robbing has the potential to strongly affect male and female reproductive fitness of plants. One example of nectar theft is that shown by striped-squirrels (Tamiops swinhoei) on a number of ginger species, including Alpinia roxburghii and A. kwangsiensis (Zingiberaceae). In this study, we used a fluorescent dye as a pollen analogue, and measured fruit and seed output, to test the effect of squirrel nectar-robbing on A. roxburghii reproductive fitness. Pollen transfer between robbed and unrobbed flowers was assessed by comparing 60 randomly established plots containing robbed and unrobbed flowers. The frequency of squirrel robbing visits and broken styles were recorded from a number of flowers for five consecutive days. Two bee species (Bombus eximius and Apis cerana), were the primary pollinators, and their visitation frequency was recorded for six consecutive days. The results showed that fluorescent powder from unrobbed flowers was dispersed further, and to a greater number of flowers than that placed on robbed flowers. Additionally, robbing flowers caused significant damage to reproductive organs, resulting in lower fruit and seed sets in robbed than in unrobbed flowers and influencing both male and female fitness. The frequency of the primary pollinator visits (B. eximius) was significantly higher for unrobbed plants than for robbed plants. The present study clearly shows the negative impact of squirrel robbing on A. roxburghii male reproductive fitness and neutral impact on female reproductive fitness.

  16. Nectar robbing, forager efficiency and seed set: Bumblebees foraging on the self incompatible plant Linaria vulgaris (Scrophulariaceae)

    NASA Astrophysics Data System (ADS)

    Stout, Jane C.; Allen, John A.; Goulson, Dave

    2000-07-01

    In southern England, Linaria vulgaris (common yellow toadflax) suffers from high rates of nectar robbery by bumblebees. In a wild population of L. vulgaris we found that 96 % of open flowers were robbed. Five species of bumblebee were observed foraging on these flowers, although short-tongued species ( Bombus lapidarius, B. lucorum and B. terrestris) robbed nectar whilst longer-tongued ones behaved as legitimate pollinators ( B. hortorum and B. pascuorum). Nectar rewards were highly variable; on average there was less nectar in robbed than in unrobbed flowers, but this difference was not statistically significant. The proportion of flowers containing no nectar was significantly higher for robbed flowers compared with unrobbed flowers. Secondary robbers and legitimate pollinators had similar handling times on flowers and, assuming they select flowers at random to forage on, received approximately the same nectar profit per minute, largely because most flowers had been robbed. There was no significant difference in the number of seeds in pods of robbed flowers and in pods of flowers that were artificially protected against robbing. However, more of the robbed flowers set at least some seed than the unrobbed flowers, possibly as a consequence of the experimental manipulation. We suggest that nectar robbing has little effect on plant fecundity because legitimate foragers are present in the population, and that seed predation and seed abortion after fertilization may be more important factors in limiting seed production in this species.

  17. Role of the mar-sox-rob regulon in regulating outer membrane porin expression.

    PubMed

    Chubiz, Lon M; Rao, Christopher V

    2011-05-01

    Multiple factors control the expression of the outer membrane porins OmpF and OmpC in Escherichia coli. In this work, we investigated the role of the mar-sox-rob regulon in regulating outer membrane porin expression in response to salicylate. We provide both genetic and physiological evidence that MarA and Rob can independently activate micF transcription in response to salicylate, leading to reduced OmpF expression. MarA was also found to repress OmpF expression through a MicF-independent pathway. In the case of OmpC, we found that its transcription was moderately increased in response to salicylate. However, this increase was independent of MarA and Rob. Finally, we found that the reduction in OmpF expression in a tolC mutant is due primarily to Rob. Collectively, this work further clarifies the coordinated role of MarA and Rob in regulating the expression of the outer membrane porins.

  18. Nectar robbing positively influences the reproductive success of Tecomella undulata (Bignoniaceae).

    PubMed

    Singh, Vineet Kumar; Barman, Chandan; Tandon, Rajesh

    2014-01-01

    The net consequence of nectar robbing on reproductive success of plants is usually negative and the positive effect is rarely produced. We evaluated the influence of nectar robbing on the behaviour of pollinators and the reproductive success of Tecomella undulata (Bignoniaceae) in a natural population. Experimental pollinations showed that the trees were strictly self-incompatible. The three types of floral colour morphs of the tree viz. red, orange and yellow, lacked compatibility barriers. The pollinators (Pycnonotus cafer and Pycnonotus leucotis) and the robber (Nectarinia asiatica) showed equal preference for all the morphs, as they visited each morph with nearly equal frequency and flower-handling time. The sunbirds caused up to 60% nectar robbing, mostly (99%) by piercing through the corolla tube. Although nectar is replenished at regular intervals, insufficient amount of nectar compelled the pollinators to visit additional trees in bloom. Data of manual nectar robbing from the entire tree showed that the pollinators covered lower number of flowers per tree (5 flowers/tree) and more trees per bout (7 trees/bout) than the unrobbed ones (19 flowers/tree and 2 trees bout). The robbed trees set a significantly greater amount of fruits than the unrobbed trees. However, the number of seeds in a fruit did not differ significantly. The study shows that plant-pollinator-robber interaction may benefit the self-incompatible plant species under conditions that increases the visits of pollinators among the compatible conspecifics in a population.

  19. Nectar Robbing Positively Influences the Reproductive Success of Tecomella undulata (Bignoniaceae)

    PubMed Central

    Singh, Vineet Kumar; Barman, Chandan; Tandon, Rajesh

    2014-01-01

    The net consequence of nectar robbing on reproductive success of plants is usually negative and the positive effect is rarely produced. We evaluated the influence of nectar robbing on the behaviour of pollinators and the reproductive success of Tecomella undulata (Bignoniaceae) in a natural population. Experimental pollinations showed that the trees were strictly self-incompatible. The three types of floral colour morphs of the tree viz. red, orange and yellow, lacked compatibility barriers. The pollinators (Pycnonotus cafer and Pycnonotus leucotis) and the robber (Nectarinia asiatica) showed equal preference for all the morphs, as they visited each morph with nearly equal frequency and flower-handling time. The sunbirds caused up to 60% nectar robbing, mostly (99%) by piercing through the corolla tube. Although nectar is replenished at regular intervals, insufficient amount of nectar compelled the pollinators to visit additional trees in bloom. Data of manual nectar robbing from the entire tree showed that the pollinators covered lower number of flowers per tree (5 flowers/tree) and more trees per bout (7 trees/bout) than the unrobbed ones (19 flowers/tree and 2 trees bout). The robbed trees set a significantly greater amount of fruits than the unrobbed trees. However, the number of seeds in a fruit did not differ significantly. The study shows that plant-pollinator-robber interaction may benefit the self-incompatible plant species under conditions that increases the visits of pollinators among the compatible conspecifics in a population. PMID:25036554

  20. Building a Career in America's Community Colleges: Essays by Rob Jenkins from "The Chronicle of Higher Education"

    ERIC Educational Resources Information Center

    D'Errico, Deanna, Ed.

    2010-01-01

    This volume collects essays Rob Jenkins originally wrote for "The Two-Year Track" column in "The Chronicle of Higher Education". Drawing on his own experience, Rob has, for many years, been dispensing much-appreciated advice from the frontline--to those considering a community college career as well as those who desire to move up the ranks. This…

  1. RobOKoD: microbial strain design for (over)production of target compounds

    PubMed Central

    Stanford, Natalie J.; Millard, Pierre; Swainston, Neil

    2015-01-01

    Sustainable production of target compounds such as biofuels and high-value chemicals for pharmaceutical, agrochemical, and chemical industries is becoming an increasing priority given their current dependency upon diminishing petrochemical resources. Designing these strains is difficult, with current methods focusing primarily on knocking-out genes, dismissing other vital steps of strain design including the overexpression and dampening of genes. The design predictions from current methods also do not translate well-into successful strains in the laboratory. Here, we introduce RobOKoD (Robust, Overexpression, Knockout and Dampening), a method for predicting strain designs for overproduction of targets. The method uses flux variability analysis to profile each reaction within the system under differing production percentages of target-compound and biomass. Using these profiles, reactions are identified as potential knockout, overexpression, or dampening targets. The identified reactions are ranked according to their suitability, providing flexibility in strain design for users. The software was tested by designing a butanol-producing Escherichia coli strain, and was compared against the popular OptKnock and RobustKnock methods. RobOKoD shows favorable design predictions, when predictions from these methods are compared to a successful butanol-producing experimentally-validated strain. Overall RobOKoD provides users with rankings of predicted beneficial genetic interventions with which to support optimized strain design. PMID:25853130

  2. Performance of ROB's near real-time ionospheric product during normal and disturbed space weather periods.

    NASA Astrophysics Data System (ADS)

    Bergeot, Nicolas; Chevalier, Jean-Marie; Bruyninx, Carine

    2015-04-01

    Several agencies are routinely monitoring the vertical Total Electron Content (vTEC) using GNSS data. Derived maps are available with different latencies, area extents, and grid/time resolutions. However, no high-resolution maps are publically available over Europe in near real-time. In this frame, the Royal Observatory of Belgium (ROB) developed the ROB-IONO software which takes advantage of the dense EUREF Permanent GNSS Network (EPN) to monitor the ionosphere. The main ROB products consist of ionospheric vTEC maps over Europe and their variability estimated in near real-time every 15 min on 0.5° x 0.5° grids using GPS observations. The maps are available online with a latency of ~3 min in the IONEX format at ftp://gnss.oma.be and as interactive web pages at www.gnss.be. During normal ionospheric activity, the ROB-TEC maps show a good agreement with widely used post-processed global products from IGS, CODE and ESA, with mean differences of 1.3 ± 0.9, 0.6 ± 0.7 and 0.4 ± 1.6 TECu respectively for the period 2012 to mid-2013. For a disturbed period, such as the 2003 Halloween ionospheric storm, the mean differences with IGS, CODE and ESA maps are respectively 0.9 ± 2.2, 0.1 ± 2.0 and 0.6 ± 6.8 TECu, with maximum differences (>38 TECu) occurring during the major phase of the storm. These differences are due to the lower resolution of global products in time and space compared to the ROB-TEC maps. A description of two recent events, on March 17, 2013 and February 27, 2014 highlights the capability of the method adopted to detect in near real-time abnormal ionospheric behaviour over Europe. The potential of the variability maps as an indicator of rapid ionospheric variations during the 15 min of observations is also highlighted. More than 30 ionospheric events associated with Space weather were detected during the period 2012-2014. The ionospheric perturbations are associated with Coronal Mass Ejections (CMEs, ~70% of the time), active geomagnetic conditions

  3. Quantum accelerometer: Distinguishing inertial Bob from his accelerated twin Rob by a local measurement

    SciTech Connect

    Dragan, Andrzej; Fuentes, Ivette; Louko, Jorma

    2011-04-15

    A single quantum system, such as the Unruh-DeWitt detector, can be used to determine absolute acceleration by local measurements on a quantum field. To show this, we consider two kinematically indistinguishable scenarios: an inertial observer, Bob, measuring the field of a uniformly accelerated cavity, and his noninertial twin, Rob, accelerating and making measurements in a stationary cavity. We find that these scenarios can be distinguished in the nonrelativistic regime only by measurements on highly excited massive fields, allowing one to detect the noninertialness of the reference frame.

  4. Rethinking the Boundaries and Burdens of Parental Authority over Education: A Response to Rob Reich's Case Study of Homeschooling

    ERIC Educational Resources Information Center

    Glanzer, Perry L.

    2008-01-01

    Rob Reich's claim that fruitful discussions about the balance among state, parental, and children's educational interests would benefit by contemplating the widespread phenomenon of homeschooling is a welcome suggestion. His policy recommendations, however, place an unjustified burden on parents to show the adequacy of homeschooling arrangements…

  5. Using Classroom Observations to Measure Teacher Effectiveness: Q&A with Rob Ramsdell. REL Mid-Atlantic Webinar

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    In this webinar, Mr. Rob Ramsdell, Vice President, Cambridge Education, discussed the use of classroom observations as one measure of teacher effectiveness in a comprehensive educator support system. Mr. Ramsdell presented research-based recommendations for improving the quality and rigor of classroom observations. This Q&A addressed the…

  6. 78 FR 46598 - Notice of Availability of the Draft Rob Jaggers Camping Area Business Plan and Expanded Amenity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... Bureau of Land Management Notice of Availability of the Draft Rob Jaggers Camping Area Business Plan and Expanded Amenity Fee Schedule for the Fort Stanton/ Snowy River National Conservation Area, New Mexico AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: In accordance with the...

  7. Analytic Calculation of Noise Power Robbing, NPR, and Polarization Isolation Degradation

    NASA Technical Reports Server (NTRS)

    Peters, Robert; Woolner, Peter; Ekelman, Ernest

    2008-01-01

    Three Geostationary Operational Environmental Satellite (GOES) R transponders (services) required analysis and measurements to develop an accurate link budget. These are a) Search and Rescue transponder which suffers from power robbing due to thermal uplink noise, b) the Data Collection Platform Report which suffers from degradation due to NPR (Noise Power Ratio), and c) GOES Rebroadcast transponder which uses a dual circular downlink L band for which there was no depolarization data. The first two services required development of extended link budget to analytically calculate the impact of these degradations which are shown to have a significant impact on the link budget. The third service required measurements of atmospheric L band CP depolarization as there were no known previous measurements and results are reported her

  8. Immediate effects of nectar robbing by Palestine sunbirds (Nectarinia osea) on nectar alkaloid concentrations in tree tobacco (Nicotiana glauca).

    PubMed

    Kaczorowski, Rainee L; Koplovich, Avi; Sporer, Frank; Wink, Michael; Markman, Shai

    2014-04-01

    Plant secondary metabolites (PSMs), such as alkaloids, are often found in many parts of a plant, including flowers, providing protection to the plant from various types of herbivores or microbes. PSMs are also present in the floral nectar of many species, but typically at lower concentrations than in other parts of the plant. Nectar robbers often damage floral tissue to access the nectar. By doing so, these nectar robbers may initiate an increase of PSMs in the floral nectar. It is often assumed that it takes at least a few hours before the plant demonstrates an increase in PSMs. Here, we addressed the question of whether PSMs in the floral tissue are immediately being released into the floral nectar following nectar robbing. To address this research question, we investigated whether there was an immediate effect of nectar robbing by the Palestine Sunbird (Nectarinia osea) on the concentration of nectar alkaloids, nicotine and anabasine, in Tree Tobacco (Nicotiana glauca). We found that the concentration of anabasine, but not nicotine, significantly increased in floral nectar immediately following simulated nectar robbing. These findings suggest that nectar robbers could be ingesting greater amounts of PSMs than they would if they visit flowers legitimately. As a consequence, increased consumption of neurotoxic nectar alkaloids or other PSMs could have negative effects on the nectar robber.

  9. Two simultaneous suicidal gunshots to the head with robbed police guns.

    PubMed

    Padosch, S A; Dettmeyer, R B; Schyma, C W; Schmidt, P H; Madea, B

    2006-05-10

    The suicidal infliction of two gunshot wounds to the head represents a critical issue for medicolegal investigation. In principle, simultaneous infliction with two firearms or third parties' involvement, i.e. two consecutive gunshots, have to be considered. We report for the first time on a case of suicidal infliction of two simultaneous gunshots to the head (oral, temporal) with Action 4 expanding ammunition. A male had robbed two service guns and committed suicide thereafter under the influence of high-dose alcohol and cocaine. Interestingly, Action 4 ammunition had been used, leading to an uncommon gunshot wound morphology and extensive backspatter. At the scene, these findings caused confusion; moreover, the number of gunshot wounds was unclear, until autopsy revealed two gunshot wounds to the head, which had obviously been inflicted simultaneously. Expanding ammunition like QD-PEP and Action 4, used by several German federal state police forces, can cause an atypical gunshot wound morphology, most probably due to its peculiar deformation behaviour. Investigators should be careful when interpreting gunshot wound morphology at the scene after usage of such expanding ammunition. With regard to reconstruction in cases of two gunshot wounds to the head and two guns at the scene, two simultaneous gunshots should be taken into consideration. PMID:15978762

  10. Bioflocculant production by Virgibacillus sp. Rob isolated from the bottom sediment of Algoa Bay in the Eastern Cape, South Africa.

    PubMed

    Cosa, Sekelwa; Mabinya, Leonard V; Olaniran, Ademola O; Okoh, Omobola O; Bernard, Kim; Deyzel, Shaun; Okoh, Anthony I

    2011-01-01

    A bioflocculant-producing marine bacterium previously isolated from marine sediment of Algoa Bay was screened for flocculant production. Comparative analysis of 16S rDNA sequence identified the isolate to have 99% similarity to Virgibacillus sp. XQ-1 and it was deposited in the GenBank as Virgibacillus sp. Rob with accession number HQ537127. The bacterium produced biflocculants optimally in glucose (70.4%) and peptone (70.4%) as sole sources of carbon and nitrogen, alkaline pH (12) (74%); and the presence of Fe2+ (74%). Chemical analysis of the bioflocculant revealed it to be a polysaccharide. PMID:21403600

  11. The consequences of direct versus indirect species interactions to selection on traits: pollination and nectar robbing in Ipomopsis aggregata.

    PubMed

    Irwin, Rebecca E

    2006-03-01

    Organisms experience a complex suite of species interactions. Although the ecological consequences of direct versus indirect species interactions have received attention, their evolutionary implications are not well understood. I examined selection on floral traits through direct versus indirect pathways of species interactions using the plant Ipomopsis aggregata and its pollinators and nectar robber. Using path analysis and structural equation modeling, I tested competing hypotheses comparing the relative importance of direct (pollinator-mediated) versus indirect (robber-mediated) interactions to trait selection through female plant function in 2 years. The hypothesis that provided the best fit to the observed data included robbing and pollination, suggesting that both interactors are important in driving selection on some traits; however, the direction and intensity of selection through robbing versus pollination varied between years. I then increased my scope of inference by assessing traits and species interactions across more years. I found that the potential for temporal variation in the direction and intensity of selection was pronounced. Taken together, results suggest that assessing the broader context in which organisms evolve, including both direct and indirect interactions and across multiple years, can provide increased mechanistic understanding of the diversity of ways that animals shape floral and plant evolution.

  12. AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora.

    PubMed

    Pletzer, Daniel; Schweizer, Gabriel; Weingart, Helge

    2014-09-01

    Transcriptional regulators of the AraC/XylS family have been associated with multidrug resistance, organic solvent tolerance, oxidative stress, and virulence in clinically relevant enterobacteria. In the present study, we identified four homologous AraC/XylS regulators, Rob, SoxS, PliA, and OpiA, from the fire blight pathogen Erwinia amylovora Ea1189. Previous studies have shown that the regulators MarA, Rob, and SoxS from Escherichia coli mediate multiple-antibiotic resistance, primarily by upregulating the AcrAB-TolC efflux system. However, none of the four AraC/XylS regulators from E. amylovora was able to induce a multidrug resistance phenotype in the plant pathogen. Overexpression of rob led to a 2-fold increased expression of the acrA gene. However, the rob-overexpressing strain showed increased resistance to only a limited number of antibiotics. Furthermore, Rob was able to induce tolerance to organic solvents in E. amylovora by mechanisms other than efflux. We demonstrated that SoxS from E. amylovora is involved in superoxide resistance. A soxS-deficient mutant of Ea1189 was not able to grow on agar plates supplemented with the superoxide-generating agent paraquat. Furthermore, expression of soxS was induced by redox cycling agents. We identified two novel members of the AraC/XylS family in E. amylovora. PliA was highly upregulated during the early infection phase in apple rootstock and immature pear fruits. Multiple compounds were able to induce the expression of pliA, including apple leaf extracts, phenolic compounds, redox cycling agents, heavy metals, and decanoate. OpiA was shown to play a role in the regulation of osmotic and alkaline pH stress responses.

  13. Water quality of Rob Roy Reservoir and Lake Owen, Albany County, and Granite Springs and Crystal Lake Reservoirs, Laramie County, Wyoming, 1997-98

    USGS Publications Warehouse

    Ogle, Kathy Muller; Peterson, D.A.; Spillman, Bud; Padilla, Rosie

    1999-01-01

    The water quality of four reservoirs was assessed during 1997 and 1998 as a cooperative project between the Cheyenne Board of Public Utilities and the U. S. Geological Survey. The four reservoirs, Rob Roy, Lake Owen, Granite Springs, and Crystal Lake, provide approximately 75 percent of the public water supply for Cheyenne, Wyoming. Samples of water and bottom sediment were collected and analyzed for selected physical, chemical, and biological characteristics to provide data about the reservoirs. Water flows between the reservoirs through a series of pipelines and stream channels. The reservoirs differ in physical characteristics such as elevation, volume, and depth.Profiles of temperature, dissolved oxygen, specific conductance, and pH were examined. Three of the four reservoirs exhibited stratification during the summer. The profiles indicate that stratification develops in all reservoirs except Lake Owen. Stratification developed in Rob Roy, Granite Springs, and Crystal Lake Reservoirs by mid-July in 1998 and continued until September, with the thickness of the epilimnion increasing during that time. Secchi disk readings indicated Rob Roy Reservoir had the clearest water of the four reservoirs studied.The composition of the phytoplankton community was different in the upper two reservoirs from that in the lower two reservoirs. Many of the species found in Rob Roy Reservoir and Lake Owen are associated with oligotrophic, nutrient-poor conditions. In contrast, many of the species found in Granite Springs and Crystal Lake Reservoirs are associated with mesotrophic or eutrophic conditions. The total number of taxa identified also increased downstream.The chemical water type in the reservoirs was similar, but dissolved-solids concentrations were greater in the downstream reservoirs. Water in all four reservoirs was a calcium-bicarbonate type. In the fall of 1997, Rob Roy Reservoir had the lowest dissolved-solids concentration (19 milligrams per liter), whereas

  14. A rare Robertsonian translocation rob(14;22) carrier with azoospermia, meiotic defects, and testicular sperm aneuploidy.

    PubMed

    Sobotka, Vladimir; Vozdova, Miluse; Heracek, Jiri; Rubes, Jiri

    2015-01-01

    Male infertility is a serious problem in an increasing number of couples. We report an infertile man with non-obstructive azoospermia and karyotype 45,XY,rob(14;22). The immunofluorescence analysis of his testicular tissue using antibodies to SYCP1, SYCP3, HORMAD2, MLH1, and centromeres showed delayed synapsis of the chromosomes involved in the translocation, a varying extent of trivalent asynapsis and its association with sex chromosomes. The mean frequency of meiotic recombination per cell was within the range of normal values. Fluorescence in situ hybridization (FISH) with probes for chromosomes 14 and 22 revealed 5.83% of chromosomally abnormal testicular spermatozoa. FISH with probes for chromosomes X, Y, and 21 showed frequencies of disomic and diploid testicular spermatozoa increased when compared to ejaculated sperm of healthy donors, but comparable with published results for azoospermic patients. PGD by FISH for the translocation and aneuploidy of chromosomes X, Y, 13, 18, and 21 showed a normal chromosomal complement in one out of three analyzed embryos. A healthy carrier girl was born after the embryo transfer. This study shows the benefits of preimplantation genetic diagnosis in a case of a rare Robertsonian translocation carrier with azoospermia and a relatively low frequency of chromosomally unbalanced testicular spermatozoa.

  15. Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination.

    PubMed

    San Millan, Alvaro; Garcia-Cobos, Silvia; Escudero, Jose Antonio; Hidalgo, Laura; Gutierrez, Belen; Carrilero, Laura; Campos, Jose; Gonzalez-Zorn, Bruno

    2010-04-01

    Plasmid pB1000 is a mobilizable replicon bearing the bla(ROB-1) beta-lactamase gene that we have recently described in Haemophilus parasuis and Pasteurella multocida animal isolates. Here we report the presence of pB1000 and a derivative plasmid, pB1000', in four Haemophilus influenzae clinical isolates of human origin. Pulsed-field gel electrophoresis showed unrelated patterns in all strains, indicating that the existence of pB1000 in H. influenzae isolates is not the consequence of clonal dissemination. The replicon can be transferred both by transformation and by conjugation into H. influenzae, giving rise to recipients resistant to ampicillin and cefaclor (MICs, > or =64 microg/ml). Stability experiments showed that pB1000 is stable in H. influenzae without antimicrobial pressure for at least 60 generations. Competition experiments between isogenic H. influenzae strains with and without pB1000 revealed a competitive disadvantage of 9% per 10 generations for the transformant versus the recipient. The complete nucleotide sequences of nine pB1000 plasmids from human and animal isolates, as well as the epidemiological data, suggest that animal isolates belonging to the Pasteurellaceae act as an antimicrobial resistance reservoir for H. influenzae. Further, since P. multocida is the only member of this family that can colonize both humans and animals, we propose that P. multocida is the vehicle for the transport of pB1000 between animal- and human-adapted members of the Pasteurellaceae.

  16. A rare Robertsonian translocation rob(14;22) carrier with azoospermia, meiotic defects, and testicular sperm aneuploidy.

    PubMed

    Sobotka, Vladimir; Vozdova, Miluse; Heracek, Jiri; Rubes, Jiri

    2015-01-01

    Male infertility is a serious problem in an increasing number of couples. We report an infertile man with non-obstructive azoospermia and karyotype 45,XY,rob(14;22). The immunofluorescence analysis of his testicular tissue using antibodies to SYCP1, SYCP3, HORMAD2, MLH1, and centromeres showed delayed synapsis of the chromosomes involved in the translocation, a varying extent of trivalent asynapsis and its association with sex chromosomes. The mean frequency of meiotic recombination per cell was within the range of normal values. Fluorescence in situ hybridization (FISH) with probes for chromosomes 14 and 22 revealed 5.83% of chromosomally abnormal testicular spermatozoa. FISH with probes for chromosomes X, Y, and 21 showed frequencies of disomic and diploid testicular spermatozoa increased when compared to ejaculated sperm of healthy donors, but comparable with published results for azoospermic patients. PGD by FISH for the translocation and aneuploidy of chromosomes X, Y, 13, 18, and 21 showed a normal chromosomal complement in one out of three analyzed embryos. A healthy carrier girl was born after the embryo transfer. This study shows the benefits of preimplantation genetic diagnosis in a case of a rare Robertsonian translocation carrier with azoospermia and a relatively low frequency of chromosomally unbalanced testicular spermatozoa. PMID:26043179

  17. Effect of Transcriptional Activators SoxS, RobA, and RamA on Expression of Multidrug Efflux Pump AcrAB-TolC in Enterobacter cloacae

    PubMed Central

    Pérez, Astrid; Poza, Margarita; Aranda, Jesús; Latasa, Cristina; Medrano, Francisco Javier; Tomás, María; Romero, Antonio; Lasa, Iñigo

    2012-01-01

    Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in multidrug resistance in Enterobacter cloacae. However, the underlying mechanism that regulates the system in this microorganism remains unknown. In Escherichia coli, the transcription of acrAB is upregulated under global stress conditions by proteins such as MarA, SoxS, and Rob. In the present study, two clinical isolates of E. cloacae, EcDC64 (a multidrug-resistant strain overexpressing the AcrAB-TolC efflux pump) and Jc194 (a strain with a basal AcrAB-TolC expression level), were used to determine whether similar global stress responses operate in E. cloacae and also to establish the molecular mechanisms underlying this response. A decrease in susceptibility to erythromycin, tetracycline, telithromycin, ciprofloxacin, and chloramphenicol was observed in clinical isolate Jc194 and, to a lesser extent in EcDC64, in the presence of salicylate, decanoate, tetracycline, and paraquat. Increased expression of the acrAB promoter in the presence of the above-described conditions was observed by flow cytometry and reverse transcription-PCR, by using a reporter fusion protein (green fluorescent protein). The expression level of the AcrAB promoter decreased in E. cloacae EcDC64 derivates deficient in SoxS, RobA, and RamA. Accordingly, the expression level of the AcrAB promoter was higher in E. cloacae Jc194 strains overproducing SoxS, RobA, and RamA. Overall, the data showed that SoxS, RobA, and RamA regulators were associated with the upregulation of acrAB, thus conferring antimicrobial resistance as well as a stress response in E. cloacae. In summary, the regulatory proteins SoxS, RobA, and RamA were cloned and sequenced for the first time in this species. The

  18. MarA, SoxS and Rob of Escherichia coli – Global regulators of multidrug resistance, virulence and stress response

    PubMed Central

    Duval, Valérie; Lister, Ida M.

    2014-01-01

    Bacteria have a great capacity for adjusting their metabolism in response to environmental changes by linking extracellular stimuli to the regulation of genes by transcription factors. By working in a co-operative manner, transcription factors provide a rapid response to external threats, allowing the bacteria to survive. This review will focus on transcription factors MarA, SoxS and Rob in Escherichia coli, three members of the AraC family of proteins. These homologous proteins exemplify the ability to respond to multiple threats such as oxidative stress, drugs and toxic compounds, acidic pH, and host antimicrobial peptides. MarA, SoxS and Rob recognize similar DNA sequences in the promoter region of more than 40 regulatory target genes. As their regulons overlap, a finely tuned adaptive response allows E. coli to survive in the presence of different assaults in a co-ordinated manner. These regulators are well conserved amongst Enterobacteriaceae and due to their broad involvement in bacterial adaptation in the host, have recently been explored as targets to develop new anti-virulence agents. The regulators are also being examined for their roles in novel technologies such as biofuel production. PMID:24860636

  19. One-step "green" preparation of graphene nanosheets and carbon nanospheres mixture by electrolyzing graphite rob and its application for glucose biosensing.

    PubMed

    Yin, Huanshun; Zhou, Yunlei; Meng, Xiaomeng; Shang, Kun; Ai, Shiyun

    2011-12-15

    The graphene nanosheets and carbon nanospheres mixture (GNS-CNS) was prepared by electrolyzing graphite rob in KNO(3) solution under constant current, which was characterized by TEM, AFM, SEM, FT-IR, XRD, XPS, TGA and UV-vis. The nano-mixture can keep stable in water for more than one month. Based on this kind of mixture material, a novel electrochemical biosensing platform for glucose determination was developed. Cyclic voltammetry of glucose oxidase (GOD) immobilized on GNS-CNS/GCE exhibited a pair of well-defined quasi-reversible redox peaks at -0.488 V (E(pa)) and -0.509 V (E(pc)) by direct electron transfer between the protein and the electrode. The charge-transfer coefficient (α) was 0.51, the electron transfer rate constant was 2.64 s(-1) and the surface coverage of HRP was 3.18×10(-10) mol cm(-2). The immobilized GOD could retain its bioactivity and catalyze the reduction of dissolved oxygen. The glucose biosensor has a linear range from 0.4 to 20 mM with detection limit of 0.1 mM. Moreover, the biosensor exhibits acceptable reproducibility and storage stability. The fabricated biosensor was further used to determine glucose in human plasma sample with the recoveries from 96.83% to 105.52%. Therefore, GOD/GNS-CNS/GCE could be promisingly applied to determine blood sugar concentration in the practical clinical analysis.

  20. Novel blaROB-1-Bearing Plasmid Conferring Resistance to β-Lactams in Haemophilus parasuis Isolates from Healthy Weaning Pigs

    PubMed Central

    Moleres, Javier; Santos-López, Alfonso; Lázaro, Isidro; Labairu, Javier; Prat, Cristina; Ardanuy, Carmen; González-Zorn, Bruno

    2015-01-01

    Haemophilus parasuis, the causative agent of Glässer's disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis and bronchopneumonia. Antibiotics are commonly used in disease control, and resistance to several antibiotics has been described in H. parasuis. Prediction of H. parasuis virulence is currently limited by our scarce understanding of its pathogenicity. Some genes have been associated with H. parasuis virulence, such as lsgB and group 1 vtaA, while biofilm growth has been associated with nonvirulent strains. In this study, 86 H. parasuis nasal isolates from farms that had not had a case of disease for more than 10 years were obtained by sampling piglets at weaning. Isolates were studied by enterobacterial repetitive intergenic consensus PCR and determination of the presence of lsgB and group 1 vtaA, biofilm formation, inflammatory cell response, and resistance to antibiotics. As part of the diversity encountered, a novel 2,661-bp plasmid, named pJMA-1, bearing the blaROB-1 β-lactamase was detected in eight colonizing strains. pJMA-1 was shown to share a backbone with other small plasmids described in the Pasteurellaceae, to be 100% stable, and to have a lower biological cost than the previously described plasmid pB1000. pJMA-1 was also found in nine H. parasuis nasal strains from a separate collection, but it was not detected in isolates from the lesions of animals with Glässer's disease or in nontypeable Haemophilus influenzae isolates. Altogether, we show that commensal H. parasuis isolates represent a reservoir of β-lactam resistance genes which can be transferred to pathogens or other bacteria. PMID:25747001

  1. Projeto observatórios virtuais: educação através de telescópios robóticos

    NASA Astrophysics Data System (ADS)

    Santana, P. H. S.; Shida, R. Y.

    2003-08-01

    O principal objetivo do projeto Observatórios Virtuais é o ensino na área de ciências através de atividades práticas desenvolvidas em colaboração entre instituições de pesquisa em astronomia e escolas de ensino médio e fundamental. Este ano deverá ser concluída a implantação do programa piloto de estudos, pesquisas e observação astronômica direta, com utilização em tempo real de telescópios robóticos, que assim funcionarão como "observatórios virtuais". O objetivo pedagógico das atividades práticas baseadas nas imagens atronômicas é desenvolver as habilidades e competências dos alunos no uso do método científico. Para isso, serão realizados projetos interdisciplinares, a partir de observações astronômicas, já que a astronomia é uma área interdisciplinar por excelência. Essas atividades terão níveis diferenciados de complexidade, que podem ser adequados aos vários graus do ensino e realidades regionais. Será dada ênfase ao desenvolvimento e aplicação em São Paulo, onde atua a equipe do IAG/USP. Como resultados apresentados no presente trabalho, temos a criação de um software em português para o processamento de imagens obtidas através de CCDs e a elaboração de material para as atividades educacionais relacionadas.

  2. Constitutive SoxS Expression in a Fluoroquinolone-Resistant Strain with a Truncated SoxR Protein and Identification of a New Member of the marA-soxS-rob Regulon, mdtG▿

    PubMed Central

    Fàbrega, Anna; Martin, Robert G.; Rosner, Judah L.; Tavio, M. Mar; Vila, Jordi

    2010-01-01

    Elevated levels of fluoroquinolone resistance are frequently found among Escherichia coli clinical isolates. This study investigated the antibiotic resistance mechanisms of strain NorE5, derived in vitro by exposing an E. coli clinical isolate, PS5, to two selection steps with increasing concentrations of norfloxacin. In addition to the amino acid substitution in GyrA (S83L) present in PS5, NorE5 has an amino acid change in ParC (S80R). Furthermore, we now find by Western blotting that NorE5 has a multidrug resistance phenotype resulting from the overexpression of the antibiotic resistance efflux pump AcrAB-TolC. Microarray and gene fusion analyses revealed significantly increased expression in NorE5 of soxS, a transcriptional activator of acrAB and tolC. The high soxS activity is attributable to a frameshift mutation that truncates SoxR, rendering it a constitutive transcriptional activator of soxS. Furthermore, microarray and reverse transcription-PCR analyses showed that mdtG (yceE), encoding a putative efflux pump, is overexpressed in the resistant strain. SoxS, MarA, and Rob activated an mdtG::lacZ fusion, and SoxS was shown to bind to the mdtG promoter, showing that mdtG is a member of the marA-soxS-rob regulon. The mdtG marbox sequence is in the backward or class I orientation within the promoter, and its disruption resulted in a loss of inducibility by MarA, SoxS, and Rob. Thus, chromosomal mutations in parC and soxR are responsible for the increased antibiotic resistance of NorE5. PMID:20008776

  3. Theoretical investigation on the bond dissociation enthalpies of phenolic compounds extracted from Artocarpus altilis using ONIOM(ROB3LYP/6-311++G(2df,2p):PM6) method

    NASA Astrophysics Data System (ADS)

    Thong, Nguyen Minh; Duong, Tran; Pham, Linh Thuy; Nam, Pham Cam

    2014-10-01

    Theoretical calculations have been performed to predict the antioxidant property of phenolic compounds extracted from Artocarpus altilis. The Osbnd H bond dissociation enthalpy (BDE), ionization energy (IE), and proton dissociation enthalpy (PDE) of the phenolic compounds have been computed. The ONIOM(ROB3LYP/6-311++G(2df,2p):PM6) method is able to provide reliable evaluation for the BDE(Osbnd H) in phenolic compounds. An important property of antioxidants is determined via the BDE(Osbnd H) of those compounds extracted from A. altilis. Based on the BDE(Osbnd H), compound 12 is considered as a potential antioxidant with the estimated BDE value of 77.3 kcal/mol in the gas phase.

  4. Mixed-Methods Study that Examines Nine Science Teachers' Perceptions of Slooh Robotic Telescope for Teaching Astronomy. (Breton Title: Métodos Mistos de Estudo que Examinam a Percepção de Nove Professores de Ciências sobre o Telescópio Robótico Slooh Para Ensino de Astronomia.) Métodos Mixtos de Estudio que Examinan la Percepcion de Nueve Profesores de Ciencias sobre EL Telescopio Robótico Slooh Para la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Gershun, Daniel C.; Slater, Timothy F.; Berryhill, Katie J.

    2014-07-01

    Although previous studies show that robotic telescopes have the potential to enhance student learning, there is comparatively little research that focuses on teacher perceptions of this technology. This study investigates: "what is the academic merit of using SLOOH robotic telescopes to teach astronomy as perceived by science teachers?" Our sample consists of nine science teachers of students aged 13-18 years. Pre- and post-tests, interviews, and surveys were collected during two weeks of a summer online course about robotic telescopes. While pre and post-tests do not reveal a statistically significant gain in astronomy content knowledge, analysis of qualitative data reveals five themes which describe the most important aspects of using SLOOH according to participants: "Images," "Interface," "Classroom Application," "Instructor Impact," and "Logistical Issues." Analysis of these themes suggests that SLOOH can provide an interactive and social learning environment with capabilities to incorporate crossdisciplinary themes. Embora estudos anteriores mostram que os telescópios robóticos têm o potencial de melhorar a aprendizagem dos alunos, há relativamente pouca investigação focada nas percepções de professores a respeito desta tecnologia. Este estudo investiga: "qual é o mérito acadêmico da utilização de telescópios robóticos Slooh para ensinar astronomia, tal como percebido pelos professores de ciências?" Nossa amostra é composta por nove professores de ciências de estudantes com idades entre 13-18 anos pré e pós-testes, entrevistas, e levantamentos foram coletados durante duas semanas de um curso on-line de verão sobre telescópios robóticos. Enquanto os testes pré e pós não revelaram um ganho estatisticamente significativo no conhecimento do conteúdo astronomia, a análise de dados qualitativos revela cinco temas que descrevem os aspectos mais importantes da utilização Slooh de acordo aos participantes: "Imagens", "Interface", "Aplica

  5. Rob Roy`s earthwood home

    SciTech Connect

    Roy, R.

    1995-04-01

    This article describes a 2,000 square foot house near the Canadian border, heated for $75 during the winter and maintaining a steady temperature. Among the design characteristics discussed are the following: round shape; earth sheltering; cordwood masonry; insulation and thermal mass; solar orientation; masonry stove; burning waste wood; floating slab foundation; surface bonded blocks; post and beam octoagon; waterproofing walls; drainage; earth roof.

  6. Robbing the Bank with a Theorem Prover

    NASA Astrophysics Data System (ADS)

    Clulow, Jolyon

    So it's a fairly provocative title, how did we get to that? Well automated tools have been successfully applied to modelling security protocols and finding attacks, and some good examples here are Gavin Lowe's work, using FDR to model the Needham-Shroeder protocols, and Larry Paulson's work using Isabella to prove the SET protocol secure. Now we come to the observation that security protocols, and security application programming interfaces are very closely related. So just to define what we mean by a security API here. We're talking devices that offer security services, that will obviously have some interface, typically the application programming interface, and unlike a normal API it also has to enforce policy onto the user, it has to make sure that keys remain secret, that PINs aren't revealed, and that users can't generally do things that would violate the security policy.

  7. Robbing Peter...Balancing Collection Development and Reference Responsibilities.

    ERIC Educational Resources Information Center

    Null, David G.

    1988-01-01

    Examines problems of librarians responsible for both collection development and reference services, including time demands, unclear supervisory lines, and misunderstanding of collection development. The discussion includes suggestions for improving this situation, e.g., formal reporting lines for both areas, increased communication among…

  8. Robbing Peter to Pay Paul: The Case Against "Comparability"

    ERIC Educational Resources Information Center

    Walsh, Kate

    2007-01-01

    Two proposals in the bill currently circulating to reauthorize No Child Left Behind seem to be shoe-ins for making their way into federal law. The impetus behind both proposals is to help poor kids by making sure that districts spend as much money on them as gets spent on rich kids. Going against the grain, the National Council on Teacher Quality…

  9. Doing This At Bedtime Could Temporarily Rob Your Sight

    MedlinePlus

    ... while lying on their side, explained Dr. Gordon Plant, an ophthalmologist with Moorfields Eye Hospital in London. ... ve been using to read their smartphone, said Plant, senior author of a paper on the phenomenon. ...

  10. Paintball Causes Many Vision-Robbing Eye Injuries

    MedlinePlus

    ... injuries in females were baseball/softball, cycling and soccer. Despite accounting for a smaller percentage of emergency department visits, paintball and air-gun eye injuries led to 26 percent of cases involving vision ...

  11. This Is Telementoring: An Interview with Rob Somers.

    ERIC Educational Resources Information Center

    Hackworth, Bob

    1987-01-01

    Robert L. Somers, who directs the Telementoring Project at Appalachian State University, explains the project's efforts to develop inservice training packages and deliver them to developmental educators nationwide using a variety of telecommunications technologies. Reviews technical and financial aspects of project participations. (AYC)

  12. 75 FR 57664 - Airworthiness Directives; G ROB-WERKE Model G120A Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Executive Order 12866; (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... describes the unsafe condition as: GROB Aircraft AG has been informed that flap ribs P/N 120A-1053 and 120A... flap ribs P/N 120A-1053 and 120A-1054 have been found cracked during regular maintenance....

  13. Robbing Public to Pay Private? Two Cases of Refinancing Education Infrastructure in Australia

    ERIC Educational Resources Information Center

    Crump, Stephen; Slee, Roger

    2005-01-01

    This paper will explore private sector participation in public sector education in the Australian context, focusing on case studies of Queensland and New South Wales, with reference to developments in other states and territories and internationally. In Australia, most states and territories have PPP policies and key projects include the Southbank…

  14. Another Woman Gets Robbed? What Jung, Freud, Piaget, and Vygotsky Took from Sabina Spielrein

    ERIC Educational Resources Information Center

    Aldridge, Jerry

    2009-01-01

    Certainly not as many who have heard the names of Carl Jung, Sigmund Freud, Jean Piaget, and Lev Vygotsky, have heard of Sabina Spielrein. While Spielrein had numerous face-to-face encounters, some personal and some professional, with all four men, and the accounting of her life and the interactions she had with them has been the content of…

  15. Robbing Peter to Pay Paul: The Price of Standards-Driven Education

    ERIC Educational Resources Information Center

    Ingleby, Ewan

    2010-01-01

    This article presents research findings on mentoring within PCET ITT (Post-Compulsory Education and Training Initial Teacher Training). The research has identified that mentors and mentees consider that the role of the mentor is unclear. Moreover, mentors are unsure of the aims of PCET ITT programmes. The inconsistency of mentor training…

  16. Robbing Peter to Pay Paul: Coverage of State and International Information in Government Documents Courses

    ERIC Educational Resources Information Center

    Griffiths, David; Hogenboom, Karen

    2005-01-01

    The authors surveyed instructors of graduate-level government documents courses in the United States regarding their coverage of IGO, foreign, and state government information. Though instructors value this information, most allot too few class hours to it. The creation of specialized distance education courses by an alliance of LIS programs would…

  17. Too Much and Too Many: How Commercialism and Screen Technology Combine to Rob Children of Creative Play

    ERIC Educational Resources Information Center

    Linn, Susan

    2009-01-01

    Hands-on creative play is essential to children's health and well being, yet in the 21st century United States, nurturing such play has actually become countercultural. The dominant, marketing-driven, media-saturated culture dictates against it. In addition to depriving children of time spent in creative play, unlimited access to screens means…

  18. Commemorating the 20th century Darwin: Ernst Mayr's words and thoughts, five years later. Interview by Rob J. Kulathinal.

    PubMed

    Mayr, Ernst

    2010-02-01

    It has been five years since Ernst Mayr, one of the most influential evolutionary biologists of the last century, passed away. Mayr's seminal work as a naturalist and, in particular, as a bird systematist allowed him to approach the species problem in a revolutionary way. As a leading architect of the Modern Evolutionary Synthesis, Mayr helped integrate Darwinian theory with the broad fields of systematics and genetics. We pay tribute to this legend by publishing an interview taken shortly before his death.

  19. Bringing compassion to the ethical dilemma in killing kangaroos for conservation: comment on "Conservation through sustainable use" by Rob Irvine.

    PubMed

    Ramp, Daniel

    2013-06-01

    Ethical debate on the killing of kangaroos has polarised conservation and animal welfare science, yet at the heart of these scientific disciplines is the unifying aim of reducing harm to non-human animals. This aim provides the foundation for common ground, culminating in the development of compassionate conservation principles that seek to provide mechanisms for achieving both conservation and welfare goals. However, environmental decision-making is not devoid of human interests, and conservation strategies are commonly employed that suit entrenched positions and commercial gain, rather than valuing the needs of the non-human animals in need of protection. The case study on the wild kangaroo harvest presents just such a dilemma, whereby a conservation strategy is put forward that can only be rationalised by ignoring difficulties in the potential for realising conservation benefits and the considerable welfare cost to kangaroos. Rather than an open debate on the ethics of killing game over livestock, in this response I argue that efforts to bring transparency and objectivity to the public debate have to date been obfuscated by those seeking to maintain entrenched interests. Only by putting aside these interests will debate about the exploitation of wildlife result in humane, compassionate, and substantive conservation benefits.

  20. Isolation breeds naivety: island living robs Australian varanid lizards of toad-toxin immunity via four-base-pair mutation.

    PubMed

    Ujvari, Beata; Mun, Hee-chang; Conigrave, Arthur D; Bray, Alessandra; Osterkamp, Jens; Halling, Petter; Madsen, Thomas

    2013-01-01

    Since their introduction to the toad-free Australian continent cane toads (Bufo marinus) have caused a dramatic increase in naïve varanid mortality when these large lizards attempt to feed on this toxic amphibian. In contrast Asian-African varanids, which have coevolved with toads, are resistant to toad toxin. Toad toxins, such as Bufalin target the H1-H2 domain of the α(1) subunit of the sodium-potassium-ATPase enzyme. Sequencing of this domain revealed identical nucleotide sequences in four Asian as well as in three African varanids, and identical sequences in all 11 Australian varanids. However, compared to the Asian-African varanids, the Australian varanids showed four-base-pair substitutions, resulting in the alteration in three of the 12 amino acids representing the H1-H2 domain. The phenotypic effect of the substitutions was investigated in human embryonic kidney (HEK) 293 cells stably transfected with the Australian and the Asian-African H1-H2 domains. The transfections resulted in an approximate 3000-fold reduction in resistance to Bufalin in the Australian HEK293 cells compared to the Asian-African HEK293 cells, demonstrating the critical role of this minor mutation in providing Bufalin resistance. Our study hence presents a clear link between genotype and phenotype, a critical step in understanding the evolution of phenotypic diversity.

  1. An Industrial Perspective of CAM/ROB Fuzzy Integrated Postprocessing Implementation for Redundant Robotic Workcells Applicability for Big Volume Prototyping

    NASA Astrophysics Data System (ADS)

    Andrés, J.; Gracia, L.; Tornero, J.; García, J. A.; González, F.

    2009-11-01

    The implementation of a postprocessor for the NX™ platform (Siemens Corp.) is described in this paper. It is focused on a milling redundant robotic milling workcell consisting of one KUKA KR 15/2 manipulator (6 rotary joints, KRC2 controller) mounted on a linear axis and synchronized with a rotary table (i.e., two additional joints). For carrying out a milling task, a choice among a set of possible configurations is required, taking into account the ability to avoid singular configurations by using both additional joints. Usually, experience and knowledge of the workman allow an efficient control in these cases, but being it a tedious job. Similarly to this expert knowledge, a stand-alone fuzzy controller has been programmed with Matlab's Fuzzy Logic Toolbox (The MathWorks, Inc.). Two C++ programs complement the translation of the toolpath tracking (expressed in the Cartesian space) from the NX™-CAM module into KRL (KUKA Robot Language). In order to avoid singularities or joint limits, the location of the robot and the workpiece during the execution of the task is fit after an inverse kinematics position analysis and a fuzzy inference (i.e., fuzzy criterion in the Joint Space). Additionally, the applicability of robot arms for the manufacture of big volume prototypes with this technique is proven by means of one case studied. It consists of a big orographic model to simulate floodways, return flows and retention storage of a reservoir in the Mijares river (Puebla de Arenoso, Spain). This article deals with the problem for a constant tool orientation milling process and sets the technological basis for future research at five axis milling operations.

  2. Calculated properties of some oxoborons R-B≡) and their higher energy isomers R-O=B

    NASA Astrophysics Data System (ADS)

    Nguyen, Minh Tho; Groarke, Peter J.; Ha, Tae-Kyu

    Ab initio molecular orbital calculations have been employed to study four simple oxoboron molecules, XBO (X = H, F, Cl and CH3) and their isomers XOB. Several properties of oxoborons including the geometries, rotational constants, vibrational wavenumbers, thermochemical parameters and nuclear quadrupole coupling constants have been calculated and thereby predicted using appropriate correction schemes based on available experimental data. Energy barriers for the 1,2-shifts obtained at the MP4/DZP level using MP2/DZP-geometries suggest that, while HOB and CH3OB are relatively stable with respect to unimolecular rearrangement (energy barrier of about 25 kcal mol-1), FOB and ClOB are unstable in this regard. The former have bent equilibrium structures and their energy is quite high relative to their oxoboron isomers (≥ 50 kcal mol-1). An analysis based on the Boys' localized orbitals and molecular electrostatic potentials discloses that during the 1,2-shifts, the migrating group (H or CH3) behaves essentially as a cationic species moving between two electron pairs.

  3. Identity and generic placement of Phestinia costella Hampson (Lepidoptera: Pyralidae: Phycitinae) reared on the invasive plant Chromolaena odorata (L.) R. M. King & H. Rob (Asteraceae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We provide descriptions and illustrations for identification of Phestinia costella Hampson, a stem gall producer on the invasive plant Chromolaena odorata (L.) R. M. King & H. Robinson (Asteraceae) that has been investigated for biological control measures. Specimens collected from C. odorata on Tr...

  4. Larvicidal activity of Ipomoea cairica (L.) Sweet and Ageratina adenophora (Spreng.) King & H. Rob. plant extracts against arboviral and filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae).

    PubMed

    Samuel, Lallianrawna; Lalrotluanga; Muthukumaran, Rajendra Bose; Gurusubramanian, Guruswami; Senthilkumar, Nachimuthu

    2014-06-01

    Culex quinquefasciatus Say, an arboviral and filarial vector, is one of the most widespread mosquitoes in the world, and insecticide-resistant populations have been reported worldwide. Due to the emergence of resistance in C. quinquefasciatus plant based products or plant extracts may be alternative sources in integrated vector management program. The present study was carried out to establish the larvicidal activities of crude solvent extracts prepared from flowers and leaves of Ipomoea cairica and Ageratina adenophora against third instar larvae of C. quinquefasciatus as target species. The plant extracts were prepared with petroleum ether, chloroform and methanol solvents using sequential extraction method to determine the best extractant for subsequent isolation and characterization of active ingredient. The total yield of plant extract in the Soxhlet extraction ranged between 0.79% and 19.35%. The qualitative phytochemical study of the plant extracts from different solvents showed the presence of alkaloids, flavonoids, phenols, terpenes, saponins and tannins in different combinations. I. cairica and A. adenophora plant extracts were found to be effective against third instar larvae of C. quinquefasciatus causing 77-100% mortality at 48h. Highest mortality was observed at 500ppm and the order of larvicidal action was observed to be of methanol extract of I. cairica flower>petroleum ether extract of A. adenophora leaf>chloroform extract of I. cairica leaf. High mortality (100%) with low LC50 and LT50 were observed in methanolic flower extract (LC50 - 8.43ppm; LT50 - 2.51h at 48h) of I. cairica, and petroleum ether (LC50 - 133.56ppm; LT50 - 9.45h at 48h) leaf extract of A. adenophora. Lethal concentration (LC50 and LC90) values gradually decreased with the exposure periods, lethal time (LT50 and LT90) decreased with the concentration in bioassay experiment with the crude plant extracts. There was a significant correlation (three-way factorial ANOVA) was noticed among concentration of the plant extracts, exposure time and solvent extraction in relation to larval mortality (P<0.0001), which indicates that larval mortality is concentration dependent as well as time-dependent. Further in-depth study is needed to identify and characterize the active components present in the plant solvent extracts and implement the effective arboviral and filarial mosquito vector management program.

  5. Systemic, genotype-specific induction of two herbivore-deterrent iridoid glycosides in Plantago lanceolata L. in response to fungal infection by Diaporthe adunca (Rob.) Niessel.

    PubMed

    Marak, Hamida B; Biere, Arjen; Van Damme, Jos M M

    2002-12-01

    Iridoid glycosides are a group of terpenoid secondary plant compounds known to deter generalist insect herbivores. In ribwort plantain (Plantago lanceolata), the iridoid glycosides aucubin and catalpol can be induced following damage by insect herbivores. In this study, we investigated whether the same compounds can be induced following infection by the fungal pathogen Diaporthe adunca, the causal agent of a stalk disease in P. lanceolata. Significant induction of aucubin and catalpol was observed in two of the three plant genotypes used in this study following inoculation with the pathogen. In one of the genotypes, induction occurred within 6 hr after inoculation, and no decay was observed within 8 days. The highest level of induction was observed in reproductive tissues (spikes and stalks) where infection took place. In these tissues, iridoid glycoside levels in infected plants were, on average, 97% and 37% higher than the constitutive levels in the corresponding control plants, respectively. Significant induction was also observed in leaves (24%) and roots (17%). In addition to significant genotypic variation in the level of induction, we found genetic variation for the tissue-specific pattern of induction, further broadening the scope for evolutionary fine-tuning of induced responses. Recent studies have revealed a negative association between iridoid glycoside levels in P. lanceolata genotypes and the amount of growth and reproduction of D. adunca that these genotypes support. However, for the three genotypes used in the present study, differences in resistance were not related to their constitutive or induced levels of iridoid glycosides, suggesting that additional resistance mechanisms are important in this host-pathogen system. We conclude that iridoid glycosides in P. lanceolata can be induced both by arthropods and pathogenic micro-organisms. Pathogen infection could, therefore, potentially enhance resistance to generalist insect herbivores in this species. PMID:12564791

  6. Rob hospitals to pay poor. Hospital and system executives say Bush's plan for uninsured threatens their fiscal stability; insurers, some docs endorse it.

    PubMed

    Lubell, Jennifer; Zigmond, Jessica

    2007-01-29

    President's Bush's plan to offer tax deductions for healthcare premiums along with shifting disproportionate-share funds to the states drew howls from hospital executives who say their institutions can't afford that approach. John Bluford, left, of Truman Medical Centers in Kansas City, Mo., says the plan could have a "potentially devastating effect" on hospitals and their patients. PMID:17315346

  7. Instalación de un nuevo telescopio robótico en la estación de altura Cesco

    NASA Astrophysics Data System (ADS)

    Schwartz, M. A. Perna, P.; Mauas, P.; Veltri, A.; Hereñú, H.

    In this paper we present the works done for the installation of a 16 inches reflector telescope at the Carlos U. Cesco high altitude station of the Observatorio Astronómico Félix Aguilar; San Juan; Argentina. We describe the implementation of the software and hardware needed for the remote control of the instrument and its future robotization. FULL TEXT IN SPANISH

  8. When Art and Business Don't Mix: Overemphasis on Marketing Can Distract Artists and Rob Cultures, Argues One Art Instructor.

    ERIC Educational Resources Information Center

    MacKichan, Margaret A.

    1993-01-01

    Discusses the limited options available to Native American art students for developing artistic skills, stressing that the emphasis on mass marketing can hinder the creativity of young artists. Suggests alternatives for art programs and art students. Urges students to recognize that there are choices when it comes to serious art. (MY)

  9. Parental Origin and Timing of De Novo Robertsonian Translocation Formation

    PubMed Central

    Bandyopadhyay, Ruma; Heller, Anita; Knox-DuBois, Cami; McCaskill, Christopher; Berend, Sue Ann; Page, Scott L.; Shaffer, Lisa G.

    2002-01-01

    Robertsonian translocations (ROBs) are the most common chromosomal rearrangements in humans. ROBs are whole-arm rearrangements between the acrocentric chromosomes 13–15, 21, and 22. ROBs can be classified into two groups depending on their frequency of occurrence, common (rob(13q14q) and rob(14q21q)), and rare (all remaining possible nonhomologous combinations). Herein, we have studied 29 case subjects of common and rare de novo ROBs to determine their parental origins and timing of formation. We compared these case subjects to 35 published case subjects of common ROBs and found that most common ROBs apparently have the same breakpoints and arise mainly during oogenesis (50/54). These probably form through a common mechanism and have been termed “class 1.” Collectively, rare ROBs also occur mostly during oogenesis (7/10) but probably arise through a more “random” mechanism or a variety of mechanisms and have been termed “class 2.” Thus, we demonstrate that although both classes of ROBs occur predominantly during meiosis, the common, class 1 ROBs occur primarily during oogenesis and likely form through a mechanism distinct from that forming class 2 ROBs. PMID:12424707

  10. Practicalities of Using a Modified Version of the Cochrane Collaboration Risk of Bias Tool for Randomised and Non-Randomised Study Designs Applied in a Health Technology Assessment Setting

    ERIC Educational Resources Information Center

    Robertson, Clare; Ramsay, Craig; Gurung, Tara; Mowatt, Graham; Pickard, Robert; Sharma, Pawana

    2014-01-01

    We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. Objectives: (1) To assess time to complete RoB assessment; (2) To assess inter-rater agreement; and (3) To explore the association between RoB and treatment effect size. Methods: Cochrane risk of…

  11. Flexibility in Management of Modernization in Construction - Electrical Works/ Elastyczność W Zarządzaniu Modernizacją Obiektów Budowlanych Na Przykładzie Robót Elektrycznych

    NASA Astrophysics Data System (ADS)

    Nowotarski, Piotr; Pasławski, Jerzy

    2015-06-01

    The article presents the general principles of flexible approach, illustrated with case study regarding flexibility in modernization. Flexibility is understood in the present case as a skilful adaptation to changes in the dynamically changing environment. The essence of flexibility approach is being staged to make decisions based on environmental and process monitoring in progress. Presented case study of upgrading the electrical system in the multi-family housing in the common area is based on step by step procedure responding to damage state of this system. Simple analysis is based on cost comparison but there are other criteria (environmental, social etc.) and conflict solving situations taken into account in presented paper. Artykuł prezentuje możliwość zastosowania elastyczności w modernizacjach istniejących obiektów budowlanych na przykładzie instalacji oświetleniowej. Elastyczność jest rozumiana w tym przypadku jako umiejętne dostosowanie się do zmian w dynamicznie zmieniającym się środowisku. Istotą podejścia elastycznego jest podejmowanie odpowiednich decyzji w odpowiednim czasie opartych na monitoringu środowiska i procesu w toku. Prezentowane studium przypadku modernizacji instalacji elektrycznej w budownictwie wielorodzinnym w częściach wspólnych obiektu (korytarze, klatki schodowe, hala garażowa) opiera się na wymianie i modernizacji tylko tych punktów, które w danym momencie ulegają awarii. Prosta analiza oby typów modernizacji opiera się na porównaniu kosztów, natomiast trzeba zaznaczyć, że możliwe są także inne kryteria (środowiskowe, konfliktu społecznego, itp.), które będą przedmiotem kolejnych publikacji. Zastąpienie tradycyjnych żarówek rozwiązaniami opartymi na technologii LED z zastosowaniem czujników ruchu może prowadzić do znacznych oszczędności, ale może też oznaczać obniżenie komfortu dla użytkowników (np. dla osób starszych, którym jeden cykl działania oświetlenia nie jest wystarczający do pokonania całej drogi na korytarzu). Osiągnięcie kompromisu w tego typu konfliktach interesów może być rozwiązane za pomocą podejścia elastycznego i zwinnego.

  12. EVALUATION OF DRINKING WATER TREATMENT TECHNOLOGIES FOR REMOVAL OF ENDOCRINE DISRUPTORS

    EPA Science Inventory

    Evaluation of Drinking Water Treatment Technologies for Removal of Endocrine Disruptors. Schenck, K*, Speth, T, U.S. EPA, Cincinnati, OH, USA, Rosenblum, L, Wendelken, S, Pepich, B, and Krishnan, R, Shaw Environmental, Inc., Cincinnati, OH, USA. Many of the chemicals identified...

  13. Familiarizing Postgraduate ESL Students with the Literature Review in a WAC/EAP Engineering Classroom

    ERIC Educational Resources Information Center

    Melles, Gavin

    2005-01-01

    The literature review is an academic genre that has a natural place in theses, dissertations, and other genres such as the lab report. The typical final (fourth) year project in the engineering curriculum is an example where such an extensive review can take place (Krishnan & Kathpalia 2002). Second language students may have special…

  14. AN APPLIED ONTOLOGY TO THE MID-ATLANTIC CABLE: HISTORICAL TO MODERN INFORMATICS CONSIDERATION FROM A MATH PERSPECTIVE KAIEM L. FRINK ELIZABETH CITY STATE UNIVERSITY(ECSU)KAIEM_FRINK@HOTMAIL.COM, DR. DEWAYNE B. BRANCH ECSU, DR. ROB RASKIN JET PROPULSIONS LABORATORY GLENDA THOMAS ECSU,KENNETH JONES ECSU

    NASA Astrophysics Data System (ADS)

    Frink, K.; Branch, B. D.; Raskin, R.

    2009-12-01

    As early as the 1600's scientists in various fields world to address a global human need of human communication on a global basis by implementing the trans-Atlantic cable. The Mid 4Trans-Atlantic cable is one of the earliest forms of global commutation. Here may be the first evidence of informatics needs where science, data, and engineering were collaborated across disciplines to advance a world standard of living. This work investigates what applied ontology may have been consisting with the thought pattern of such expertise who conducted informatics arguably without computers, ontology’s, and a cyber infrastructure. In modern context, an applied ontology may best represent the body of intentional learning, research and collaboration among scientists to achieve a human goal. Perhaps if such intentional non-partisan work can achieve a solution such as Trans-Atlantic Cable, climate change may benefit from intentional collaborative ontology’s and systems of multi user knowledgebase or expert informatics systems. 1Bruce C. Heezen 1924 -1977 American Geologist famous for mapping the Mid Atlantic Mountain Ridge in the 1950’s. Heezen died in 1977 on a submarine cruise to study the Mid-Atlantic ridge near Ice land aboard the NR-1 submarine. 7Marie Tharp academic background is Bachelors Degree in English, Master Degree in Geology University of Michigan, and Mathematics Degree at the University of Tulsa. Tharp worked at Lamont- Doherty Earth Observatory at Columbia University. History of the Digital Divide during the 1600’s touches on the availability of information. 3Issue of Mathematics during the 1600’s would be lack of communications and assessment. The scientific communities cannot address climate change most largely due to language barriers amongst humans. Weight per meter for the cable and the ships weight capacity in the 1600’sWeight/per meter 2w/m=X1 taking into account that maximum depths or Atlantic Ocean was unknown at that time and still is.

  15. Obligate short-arm exchange in de novo Robertsonian translocation formation influences placement of crossovers in chromosome 21 nondisjunction.

    PubMed

    Berend, Sue Ann; Page, Scott L; Atkinson, William; McCaskill, Christopher; Lamb, Neil E; Sherman, Stephanie L; Shaffer, Lisa G

    2003-02-01

    Robertsonian translocations (ROBs) involving chromosome 21 are found in approximately 5% of patients with Down syndrome (DS). The most common nonhomologous ROB in DS is rob(14q21q). Aberrant recombination is associated with nondisjunction (NDJ) leading to trisomy 21. Haplotype analysis of 23 patients with DS and de novo rob(14q21q) showed that all translocations and all nondisjoined chromosomes 21 were maternally derived. Meiosis II NDJ occurred in 21 of 23 families. For these, a ROB DS chromosome 21 genetic map was constructed and compared to a normal female map and a published trisomy 21 map derived from meiosis II NDJ. The location of exchanges differed significantly from both maps, with a significant shift to a more distal interval in the ROB DS map. The shift may perturb segregation, leading to the meiosis II NDJ in this study, and is further evidence for crossover interference. More importantly, because the event in the short arms that forms the de novo ROB influences the placement of chiasmata in the long arm, it is most likely that the translocation formation occurs through a recombination pathway in meiosis. Additionally, we have demonstrated that events that occur in meiosis I can influence events, such as chromatid segregation in meiosis II, many decades later. PMID:12506337

  16. Interactions between nectar robbers and seed predators mediated by a shared host plant, Ipomopsis aggregata.

    PubMed

    Brody, Alison K; Irwin, Rebecca E; McCutcheon, Meghan L; Parsons, Emily C

    2008-02-01

    Animals that consume plant parts or rewards but provide no services in return are likely to have significant impacts on the reproductive success of their host plants. The effects of multiple antagonists to plant reproduction may not be predictable from studying their individual effects in isolation. If consumer behaviors are contingent on each other, such interactions may limit the ability of the host to evolve in response to any one enemy. Here, we asked whether nectar robbing by a bumblebee (Bombus occidentalis) altered the likelihood of pre-dispersal seed predation by a fly (Hylemya sp.) on a shared host plant, Ipomopsis aggregata (Polemoniaceae). We estimated the fitness consequences of the combined interactions using experimental manipulations of nectar robbing within and among sites. Within sites, nectar robbing reduced the percentage of fruits destroyed by Hylemya. However, the negative effects of robbing on seed production outweighed any advantages associated with decreased seed predation in robbed plants. We found similar trends among sites when we manipulated robbing to all plants within a local population, although the results were not statistically significant. Taken together, our results suggest that seed predation is not independent of nectar robbing. Thus, accounting for the interactions among species is crucial to predicting their ecological effects and plant evolutionary response.

  17. Disentanglement of two harmonic oscillators in relativistic motion

    SciTech Connect

    Lin, S.-Y.; Chou, C.-H.; Hu, B. L.

    2008-12-15

    We study the dynamics of quantum entanglement between two Unruh-DeWitt detectors, one stationary (Alice), and another uniformly accelerating (Rob), with no direct interaction but coupled to a common quantum field in (3+1)D Minkowski space. We find that for all cases studied the initial entanglement between the detectors disappears in a finite time ('sudden death'). After the moment of total disentanglement the correlations between the two detectors remain nonzero until late times. The relation between the disentanglement time and Rob's proper acceleration is observer dependent. The larger the acceleration is, the longer the disentanglement time in Alice's coordinate, but the shorter in Rob's coordinate.

  18. Risk of Bias in Systematic Reviews of Non-Randomized Studies of Adverse Cardiovascular Effects of Thiazolidinediones and Cyclooxygenase-2 Inhibitors: Application of a New Cochrane Risk of Bias Tool

    PubMed Central

    Bilandzic, Anja; Fitzpatrick, Tiffany; Rosella, Laura; Henry, David

    2016-01-01

    Background Systematic reviews of the effects of healthcare interventions frequently include non-randomized studies. These are subject to confounding and a range of other biases that are seldom considered in detail when synthesizing and interpreting the results. Our aims were to assess the reliability and usability of a new Cochrane risk of bias (RoB) tool for non-randomized studies of interventions and to determine whether restricting analysis to studies with low or moderate RoB made a material difference to the results of the reviews. Methods and Findings We selected two systematic reviews of population-based, controlled non-randomized studies of the relationship between the use of thiazolidinediones (TZDs) and cyclooxygenase-2 (COX-2) inhibitors and major cardiovascular events. Two epidemiologists applied the Cochrane RoB tool and made assessments across the seven specified domains of bias for each of 37 component studies. Inter-rater agreement was measured using the weighted Kappa statistic. We grouped studies according to overall RoB and performed statistical pooling for (a) all studies and (b) only studies with low or moderate RoB. Kappa scores across the seven bias domains ranged from 0.50 to 1.0. In the COX-2 inhibitor review, two studies had low overall RoB, 14 had moderate RoB, and five had serious RoB. In the TZD review, six studies had low RoB, four had moderate RoB, four had serious RoB, and two had critical RoB. The pooled odds ratios for myocardial infarction, heart failure, and death for rosiglitazone versus pioglitazone remained significantly elevated when analyses were confined to studies with low or moderate RoB. However, the estimate for myocardial infarction declined from 1.14 (95% CI 1.07–1.24) to 1.06 (95% CI 0.99–1.13) when analysis was confined to studies with low RoB. Estimates of pooled relative risks of cardiovascular events with COX-2 inhibitors compared with no nonsteroidal anti-inflammatory drug changed little when analyses were

  19. 28 CFR Appendix to Subpart Q of... - Confinement of Persons in District of Columbia Correctional Institutions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... violence means murder, manslaughter, rape, kidnapping, robbery, burglary, assault with intent to kill, assault with intent to rape, assault with intent to rob or extortion involving the threat or use...

  20. 28 CFR Appendix to Subpart Q of... - Confinement of Persons in District of Columbia Correctional Institutions

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... violence means murder, manslaughter, rape, kidnapping, robbery, burglary, assault with intent to kill, assault with intent to rape, assault with intent to rob or extortion involving the threat or use...

  1. Sailing on the "Boundless and Bottomless Sea": A View from the OIA Bridge

    ERIC Educational Resources Information Center

    Behrens, Rob

    2015-01-01

    The prevention and resolution of student complaints are critical factors in maintaining and improving the student experience. Rob Behrens looks at the wider context, drawing on lessons from beyond higher education, to examine the opportunities and possible pitfalls.

  2. ISS Update: NASA Astronaut Mike Fincke

    NASA Video Gallery

    NASA Public Affairs Officer Rob Navias talks with NASA Astronaut Mike Fincke inside the Mission Control Center at Johnson Space Center. They discuss the current activities taking place aboard the I...

  3. Reversing the Literacy Decline by Controlling the Electronic Demons.

    ERIC Educational Resources Information Center

    Shenkman, Harriet

    1985-01-01

    Computer games, rock video, television, and movies are robbing teenagers of time they should be using to develop their minds. However, the electronic media do have a positive potential. A 10-item reference list is provided. (Author/DCS)

  4. Robert Ambrose: Principal Investigator, Game Changing Development Program

    NASA Video Gallery

    Dr. Rob Ambrose is currently overseeing one very large existing project and will likely be overseeing several new starts in the near future. In addition, he has three projects: Human Robotic System...

  5. ISS Update: Keeping Track of Station Inventory – 03.14.13

    NASA Video Gallery

    Public Affairs Officer Dan Huot interviews Rob Adams, Inventory and Stowage Officer, inside the Mission Control Center. Adams and his team keep track of the gear aboard the International Space Stat...

  6. Underweight Seniors May Have Added Alzheimer's Risk

    MedlinePlus

    ... fullstory_160278.html Underweight Seniors May Have Added Alzheimer's Risk Study links lower body weight to increased ... older adults' risk of the memory-robbing disorder Alzheimer's disease, new research suggests. The study included 280 ...

  7. Welcome Back to Earth

    NASA Video Gallery

    NASA astronaut Scott Kelly is interviewed by public affairs officer Rob Navias just after returning to Earth aboard a Soyuz spacecraft on March 1, 2016 (March 2, local Kazakh time) following a 340 ...

  8. Asthma Inhalers

    MedlinePlus

    ... reduce the release of chlorofluorocarbons (CFCs) into the atmosphere when taking certain asthma medications. Until recently, most ... hydrofluoroalkane (HFA) inhalers, that do not rob the atmosphere of ozone. “The FDA [Food and Drug Administration] ...

  9. Tiny Asteroid Approaches Earth

    NASA Video Gallery

    On Oct. 15, 2010, NASA astronomer Rob Suggs captured this view of the tiny asteroid 2010 TG19 as it made its way among the stars of the constellation Pegasus. It will continue to approach during th...

  10. NASA Now: Forces and Motion: Project Morpheus

    NASA Video Gallery

    Meet NASA engineer Rob Morehead who works on the main engines for Project Morpheus, a revolutionary new robotic lander. Morpheus is a full spacecraft and rocket-powered lander, which demonstrates n...

  11. ISS Update: Progress 50 Launch and Docking with Tom Erkenswick

    NASA Video Gallery

    NASA Public Affairs Officer Rob Navias conducts an interview with Visiting Vehicle Officer Tom Erkenswick about the launch of the ISS Progress 50 resupply ship and its docking to the International ...

  12. Guidelines for growing perennial grasses for biofuel and bioproducts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Guidelines for growing perennial grasses for biofuel and bioproducts Rob Mitchell Abstract: Switchgrass, big bluestem, and warm-season grass mixtures provide numerous benefits. Existing field equipment, herbicides, and cultivar improvement promote rapid establishment in the planting year. These gra...

  13. 75 FR 65230 - Drawbridge Operation Regulation; Arkansas Waterway, Pine Bluff, AR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ...) entitled Drawbridge Operation Regulation; Arkansas Waterway, Pine Bluff, AR in the Federal Register (75 FR... Bluff, AR AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: Drawbridge operations for the Rob...

  14. Teleportation with a uniformly accelerated partner.

    PubMed

    Alsing, Paul M; Milburn, G J

    2003-10-31

    In this work, we give a description of the process of teleportation between Alice in an inertial frame, and Rob who is in uniform acceleration with respect to Alice. The fidelity of the teleportation is reduced due to Davies-Unruh radiation in Rob's frame. In so far as teleportation is a measure of entanglement, our results suggest that quantum entanglement is degraded in noninertial frames.

  15. Chinese Herbal Medicine and Fluorouracil-Based Chemotherapy for Colorectal Cancer: A Quality-Adjusted Meta-Analysis of Randomized Controlled Trials.

    PubMed

    McCulloch, Michael; Ly, Helen; Broffman, Michael; See, Caylie; Clemons, Jen; Chang, Raymond

    2016-09-01

    Background Chinese herbal medicines reportedly increase efficacy and minimize toxicity of chemotherapy; however, little attention has been paid to how poor study quality can bias outcomes. Methods We systematically searched MEDLINE, TCMLARS, EMBASE, and Cochrane Library for randomized controlled trials of Chinese herbal medicines combined with fluorouracil-based chemotherapy compared with the same chemotherapy alone. We screened for eligibility, extracted data, and pooled data with random-effects meta-analysis. Outcome measures were survival, toxicity, tumor response, performance status, quality of life, and Cochrane Risk of Bias (ROB) criteria to critically evaluate the quality of reporting in the randomized trials included in the meta-analysis. Results We found 36 potentially eligible studies, with only 3 (those with low ROB) qualifying for meta-analysis. Two reported chemotherapy-related diarrhea reduced by 57% (relative risk [RR] = 0.43; 95% CI = 0.19-1.01; I(2) test for variation in RR due to heterogeneity = 0.0%), with nonsignificant results. Two reported white blood cell toxicity reduced by 66% (RR = 0.34; 95% CI = 0.16-0.72; I(2) test for variation in RR due to heterogeneity = 0.0%), with statistically significant results. Stratifying analysis by studies with high versus low ROB, we found substantial overestimation of benefit: Studies with high ROB overestimated by nearly 2-fold reduction of platelet toxicity by Chinese herbal medicines (RR = 0.35, 95% CI = 0.15-0.84 vs RR = 0.65, 95% CI = 0.11-3.92). Studies with high ROB overestimated by nearly 2-fold reduction of vomiting toxicity (RR = 0.45, 95% CI = 0.33-0.61 vs RR = 0.87, 95% CI = 0.48-1.58). And, studies with high ROB overestimated by 21% the reduction in diarrhea toxicity (RR = 0.34, 95% CI = 0.20-0.58 vs RR = 0.43, 95% CI = 0.19-1.01). Studies with high ROB also overestimated by 16% improvement in tumor response (RR = 1.39, 95% CI = 1.18-1.63 vs RR = 1.20; 95% CI = 0.81-1.79). Not accounting for

  16. Inhibitory modulation of chemoreflex bradycardia by stimulation of the nucleus raphe obscurus is mediated by 5-HT3 receptors in the NTS of awake rats.

    PubMed

    Weissheimer, Karin Viana; Machado, Benedito H

    2007-03-30

    Several studies demonstrated the involvement of 5-hydroxytryptamine (5-HT) and its different receptor subtypes in the modulation of neurotransmission of cardiovascular reflexes in the nucleus tractus solitarii (NTS). Moreover, anatomic evidence suggests that nucleus raphe obscurus (ROb) is a source of 5-HT-containing terminals within the NTS. In the present study we investigated the possible changes in the cardiovascular responses to peripheral chemoreceptor activation by potassium cyanide (KCN, i.v.) following ROb stimulation with L-glutamate (10 nmol/50 nL) and also whether 5-HT3 receptors in the caudal commissural NTS are involved in this neuromodulation. The results showed that stimulation of the ROb with L-glutamate in awake rats (n=15) produced a significant reduction in the bradycardic response 30 s after the microinjection (-182+/-19 vs -236+/-10 bpm; Wilcoxon test) but no changes in the pressor response to peripheral chemoreceptor activation (43+/-4 vs 51+/-3 mmHg; two-way ANOVA) in relation to the control. Microinjection of 5--HT3 receptors antagonist granisetron (500 pmol/50 nL), but not the vehicle, into the caudal commissural NTS bilaterally prevented the reduction of chemoreflex bradycardia in response to microinjection of L-glutamate into ROb. These data indicate that 5-HT-containing projections from ROb to the NTS play an inhibitory neuromodulatory role in the chemoreflex evoked bradycardia by releasing 5-HT and activating 5-HT3 receptors in the caudal NTS.

  17. Final Data Report: P- and S-Wave Velocity Logging Borings C4993, C4996, and C4997 Part B: Overall Logs

    SciTech Connect

    Diehl, John; Steller, Robert

    2007-03-20

    Insitu borehole P- and S-wave velocity measurements were collected in three borings located within the Waste Treatment Plant (WTP) boundaries at the Hanford Site, southeastern Washington. Geophysical data acquisition was performed between August and October of 2006 by Rob Steller, Charles Carter, Antony Martin and John Diehl of GEOVision. Data analysis was performed by Rob Steller and John Diehl, and reviewed by Antony Martin of GEOVision, and report preparation was performed by John Diehl and reviewed by Rob Steller. The work was performed under subcontract with Battelle, Pacific Northwest Division with Marty Gardner as Battelle’s Technical Representative and Alan Rohay serving as the Technical Administrator for Pacific Northwest National Laboratory (PNNL). This report describes the field measurements, data analysis, and results of this work.

  18. Final Data Report: P- and S-Wave Velocity Logging Borings C4993, C4996, and C4997 Part A: Interval Logs

    SciTech Connect

    Steller, Robert; Diehl, John

    2007-02-01

    Insitu borehole P- and S-wave velocity measurements were collected in three borings located within the Waste Treatment Plant (WTP) boundaries at the Hanford Site, southeastern Washington. Geophysical data acquisition was performed between August and October of 2006 by Rob Steller, Charles Carter, Antony Martin and John Diehl of GEOVision. Data analysis was performed by Rob Steller and John Diehl, and reviewed by Antony Martin of GEOVision, and report preparation was performed by John Diehl and reviewed by Rob Steller. The work was performed under subcontract with Battelle, Pacific Northwest Division with Marty Gardner as Battelle’s Technical Representative and Alan Rohay serving as the Technical Administrator for Pacific Northwest National Laboratory (PNNL). This report describes the field measurements, data analysis, and results of this work.

  19. A Case Report of an Infant with Robertsonian Translocation (15;22)(q10;q10) and Literature Review.

    PubMed

    Cho, Chi Hyun; Shin, Jung-Hee; Nam, Myung Hyun; Lim, Chae Seung; Lee, Chang Kyu; Cho, Yunjung; Kim, Young Kee; Yoon, Soo Young

    2016-01-01

    Rob(15; 22) is rare and account for only 0.6% of all Robertsonian translocations. We describe a case with rob(15;22) in which the phenotype includes generalized hypotonia, respiratory distress, tent shaped upper lips, hyporeflexia and single umbilical artery. Chromosome analysis with peripheral blood was performed, while the karyotype was interpreted as 45,XX,der(15;22)(q10;q10). In Prader-Willi/Angelman Syndrome FISH studies, deletion of the SNRPN gene was not observed, but deletion of 15p11.2 was noted. Prader-Willi/Angelman Syndrome methylation-specific polymerase chain reaction and chromosomal microarrays showed negative findings. Molecular studies associated with spinal muscular atrophy and progressive muscular dystrophy also showed negative findings. We suggest that rob(15;22) and deletion of 15p11.2 could be related to clinical presentation like this case. PMID:26927352

  20. Near real-time ionospheric monitoring over Europe at the Royal Observatory of Belgium using GNSS data

    NASA Astrophysics Data System (ADS)

    Bergeot, Nicolas; Chevalier, Jean-Marie; Bruyninx, Carine; Pottiaux, Eric; Aerts, Wim; Baire, Quentin; Legrand, Juliette; Defraigne, Pascale; Huang, Wei

    2014-10-01

    Various scientific applications and services increasingly demand real-time information on the effects of space weather on Earth's atmosphere. In this frame, the Royal Observatory of Belgium (ROB) takes advantage of the dense EUREF Permanent GNSS Network (EPN) to monitor the ionosphere over Europe from the measured delays in the GNSS signals, and provides publicly several derived products. The main ROB products consist of ionospheric vertical Total Electron Content (TEC) maps over Europe and their variability estimated in near real-time every 15 min on 0.5° × 0.5° grids using GPS observations. The maps are available online with a latency of ~3 min in IONEX format at ftp://gnss.oma.be and as interactive web pages at http://www.gnss.be/Atmospheric_Maps/ionospheric_maps.php. This paper presents the method used in the ROB-IONO software to generate the maps. The ROB-TEC maps show a good agreement with widely used post-processed products such as IGS and ESA with mean differences of 1.3 ± 0.9 and 0.4 ± 1.6 TECu respectively for the period 2012 to mid-2013. In addition, we tested the reliability of the ROB-IONO software to detect abnormal ionospheric activity during the Halloween 2003 ionospheric storm. For this period, the mean differences with IGS and ESA maps are 0.9 ± 2.2 and 0.6 ± 6.8 TECu respectively with maximum differences (>38 TECu) occurring during the major phase of the storm. These differences are due to the lower resolution in time and space of both IGS and ESA maps compared to the ROB-TEC maps. A description of two recent events, one on March 17, 2013 and one on February 27, 2014 also highlights the capability of the method adopted in the ROB-IONO software to detect in near real-time abnormal ionospheric behaviour over Europe. In that frame, ROB maintains a data base publicly available with identified ionospheric events since 2012.

  1. Comment on the scaling function in AdS4 × Bbb CBbb P3

    NASA Astrophysics Data System (ADS)

    Gromov, Nikolay; Mikhaylov, Victor

    2009-04-01

    The folded spinning string in AdS3 gives us an important insight into AdS/CFT duality. Recently its one-loop energy was analyzed in the context of AdS4/CFT3 by McLoughlin and Roiban arXiv:0807.3965, by Alday, Arutyunov and Bykov arXiv:0807.4400 and by Krishnan arXiv:0807.4561. They computed the spectrum of the fluctuations around the classical solution. In this paper we reproduce their results using the algebraic curve technique and show that under some natural resummation of the fluctuation energies the one-loop energy agrees perfectly with the predictions of arXiv:0807.0777. This provides a further support of the all-loop Bethe equations and of the AdS4 × Bbb CBbb P3 algebraic curve developed in arXiv:0807.0437.

  2. Thermodynamic black di-rings

    SciTech Connect

    Iguchi, Hideo; Mishima, Takashi

    2010-10-15

    Previously the five dimensional S{sup 1}-rotating black rings have been superposed in a concentric way by some solitonic methods, and regular systems of two S{sup 1}-rotating black rings were constructed by the authors and then Evslin and Krishnan (we called these solutions 'black di-rings'). In this place we show some characteristics of the solutions of five dimensional black di-rings, especially in thermodynamic equilibrium. After the summary of the di-ring expressions and their physical quantities, first we comment on the equivalence of the two different solution sets of the black di-rings. Then the existence of thermodynamic black di-rings is shown, in which both isothermality and isorotation between the inner black ring and the outer black ring are realized. We also give detailed analysis of peculiar properties of the thermodynamic black di-ring including discussion about a certain kind of thermodynamic stability (instability) of the system.

  3. Shear flow behavior of a dynamically symmetric polymeric bicontinuous microemulsion

    NASA Astrophysics Data System (ADS)

    Zhou, Ning

    2005-03-01

    Soft materials with complex internal structure often exhibit fascinating rheological behavior. For example, under flow the poly (ethylethylene) (PEE)/poly(dimethyl siloxane) (PDMS)/PEE-PDMS polymeric bicontinuous microemulsion (BμE) showed shear-induced macrophase separation.^ 1 This was tentatively attributed to the extreme dynamical asymmetry of the two homopolymers, i.e., their viscosities differed by three orders of magnitude. To understand the role of the dynamic symmetry of a BμE when subjected to shear flow, we have developed a new ternary polymer blend system poly(butylene oxide) (PBO)/ poly(ethylenepropylene) (PEP)/PEP-PBO, which is dynamically almost symmetric. We will report on the shear flow behavior of this new BμE. Reference: [1] Krishnan et al. Phys. Rev. Lett. 2001, 87, 098301

  4. The first graduates in 1910.

    PubMed

    Cheah, J S; Ho, T M; Ng, B Y

    2005-07-01

    The Medical School in Singapore was founded on 3 July 1905 and named the Straits and Federated Malay States Government Medical School. There were 23 students in the first enrollment; 16 students attended the full course, while 7 attended a 2-year course for hospital assistants. The pioneer group of 7 that graduated in May 1910 (the Magnificent Seven) consisted of Drs Chen Su Lan, Edwin Williborod deCruz, and John Gnanapragasam from Singapore; Drs Willie Carnegie and Mark W Chill from Penang; Dr SR Krishnan from Seramban and Dr John Scott Lee from Ipoh. In December 1910, a further 6 students graduated. Of this first batch of 13 graduates in 1910, we describe the careers of 6; no records exist of the remaining 7.

  5. Field test results of the three-dimensional acquisition and tracking (3DATA) sensor system

    NASA Astrophysics Data System (ADS)

    Fairchild, Paul W.; Lilly, David; Matkin, William B.

    2004-01-01

    Trex has developed two innovative MWIR tracking systems, the Rapid Optical Beam Steering (ROBS) system and the Fast InfraRed Sniper Tracker (FIRST). ROBS was developed by Trex in the mid 1980"s for BMDO and the Navy as a prototype 0.5 meter aperture, wide-angle, multiple target detection, tracking, and imaging system with laser ranging. The smaller FIRST system was developed in the mid 1990"s by Trex for DARPA to acquire and track small caliber bullets. Both systems utilize innovative fast steering methods for achieving very high acceleration rates, ~ 1,000 radians/sec2 for ROBS and ~ 40,000 radians/sec2 for the FIRST system. Each can provide high precision 3D tracking over a large field of regard and both have been demonstrated in field tests. Presently the capabilities of these systems are being expanded. A newer version of the ROBS, 3DATA, is being completed which will provide a capability to precisely track in three dimensions up to 20 targets per second, simultaneously. In addition, an upgraded FIRST system is being designed and built which will handle multiple slow targets in addition to the faster bullets.

  6. Ending Discrimination against People with Alcohol and Drug Problems.

    ERIC Educational Resources Information Center

    Join Together, Boston, MA.

    People with alcohol or other drug disease face public and private policies that restrict their access to appropriate health care, employment, and public benefits, discouraging them from seeking treatment, robbing them of hope for recovery, and costing society millions of dollars. Join Together, a project of Boston University School of Public…

  7. Sport-Based Youth and Community Development: Beyond the Ball in Chicago

    ERIC Educational Resources Information Center

    Jacobs, Jennifer M.; Castañeda, Amy; Castañeda, Rob

    2016-01-01

    Rob and Amy Castañeda, the co-founders of a sports/play-based youth and community development organization called Beyond the Ball (www.beyondtheball.org), cite the collaborative and dynamic nature of the TPSR Alliance as an important influence for their work. Beyond the Ball serves individuals between kindergarten and post-college, in the North…

  8. Paul Goodman Then and Now: An Inquiry into Relevance.

    ERIC Educational Resources Information Center

    Greene, Maxine

    Paul Goodman's work in psychology, social criticism, linguistics, and education deserves reconsideration. His thoughts and language found their audience among the youth of the 60's who used them to articulate rebellion. The "system," viewed by Goodman, was nonexploitive but seemed to rob young people of a sense of significance. Goodman saw…

  9. The Use of EFL Reading Strategies among High School Students in Taiwan

    ERIC Educational Resources Information Center

    Chen, Kate Tzu-Ching; Chen, Sabina Chia-Li

    2015-01-01

    In the traditional English l language classroom, reading is the skill that receives the most emphasis (Susser & Rob, 1990). Learners should use reading strategies to plan how to read and to enhance their reading comprehension (Poole, 2010). The purpose of this study was to explore the use of English as a Foreign Language (EFL) reading…

  10. Development of a set of compensating Triticum aestivum-Dasypyrum villosum Robertsonian translocation lines

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dasypyrum villosum (L.) Candargy, a wild relative of bread wheat (Triticum aestivum L.) is the source of agronomically important genes for wheat improvement. The first step in exploiting this variation is the production of compensating Robertsonian translocations (cRobTs) consisting of D. villosum c...

  11. A Teaching Makeover Improves Learning for Diverse Learners

    ERIC Educational Resources Information Center

    Doubet, Kristina J.; Hockett, Jessica A.; Brighton, Catherine M.

    2016-01-01

    In many primary classrooms, the prospect of addressing standards threatens to rob young children of the joy of learning. Teachers who feel pressed to move students of all backgrounds toward mastery of increasingly complex standards may abandon rich curriculum and move toward isolated "skill drills." This may be counterproductive. The…

  12. Role models face class expulsion.

    PubMed

    Sprinks, Jennifer

    There are plans to drop Mary Seacole and Florence Nightingale from the curriculum taught in schools, according to leaked reports. Here, nurse leaders protest that this would rob young people of valuable role models and undermine the image of the profession. It is also suggested that a person's contribution to society is more important than their personality. PMID:23427681

  13. How to Fix Our Schools

    ERIC Educational Resources Information Center

    Rothstein, Richard

    2011-01-01

    Joel Klein, chancellor of the New York City public school system, and Michelle Rhee, who resigned October 13 as Washington, DC, chancellor, published a "manifesto" in the "Washington Post" claiming that the difficulty of removing incompetent teachers "has left school districts impotent and, worse, has robbed millions of children of a real future."…

  14. Using Order of Magnitude Calculations to Extend Student Comprehension of Laboratory Data

    ERIC Educational Resources Information Center

    Dean, Rob L.

    2015-01-01

    Author Rob Dean previously published an Illuminations article concerning "challenge" questions that encourage students to think imaginatively with approximate quantities, reasonable assumptions, and uncertain information. This article has promoted some interesting discussion, which has prompted him to present further examples. Examples…

  15. Pictures of Our Nobler Selves: A History of Native American Contributions to News Media.

    ERIC Educational Resources Information Center

    Trahant, Mark N.

    Many American Indians deeply resent distorted depictions of themselves in the media. They are convinced that false media caricatures have helped rob them of their history. This report addresses a fascinating incongruity: the contributions made by Native Americans to the U.S. news media--a media that has played a key role in creating the flawed…

  16. Process-Model Feminism in the Corporate University

    ERIC Educational Resources Information Center

    Spitzer-Hanks, D. T.

    2016-01-01

    In a period characterised by worries over the rise of the corporate university, it is important to ask what role feminism plays in the academy, and whether that role is commensurate with feminist values and ethics. Commercial and political pressures brought to bear on the encounter between instructor and student can rob teaching of its efficacy,…

  17. Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile.

    PubMed

    Delvecchio, Francesca Romana; Vadrucci, Elisa; Cavalcanti, Elisabetta; De Santis, Stefania; Kunde, Dale; Vacca, Michele; Myers, Jay; Allen, Frederick; Bianco, Giusy; Huang, Alex Y; Monsurro, Vladia; Santino, Angelo; Chieppa, Marcello

    2015-09-01

    Currently little is known as to how nutritionally derived compounds may affect dendritic cell (DC) maturation and potentially prevent inappropriate inflammatory responses that are characteristic of chronic inflammatory syndromes. Previous observations have demonstrated that two polyphenols quercetin and piperine delivered through reconstituted oil bodies (ROBs-QP) can influence DC maturation in response to LPS leading to a modulated inflammatory response. In the present study, we examined the molecular effects of ROBs-QP exposure on DC differentiation in mice and identified a unique molecular signature in response to LPS administration that potentially modulates DC maturation and activity in inflammatory conditions. Following LPS administration, ROBs-QP-exposed DCs expressed an altered molecular profile as compared with control DCs, including cytokine and chemokine production, chemokine receptor repertoire, and antigen presentation ability. In vivo ROBs-QP administration suppresses antigen-specific T-cell division in the draining lymph nodes resulting from a reduced ability to create stable immunological synapse. Our data demonstrate that polyphenols exposure can drive DCs toward a new anti-inflammatory molecular profile capable of dampening the inflammatory response, highlighting their potential as complementary nutritional approaches in the treatment of chronic inflammatory syndromes. PMID:26096294

  18. Informal Learning. Symposium 27. [AHRD Conference, 2001].

    ERIC Educational Resources Information Center

    2001

    This document contains three papers on informal learning and human resource development. "Workplace Learning Reviewed: Confronting the Rhetoric with Empirical Research" (Rob F. Poell, Ferd J. Van der Krogt) discusses the considerable discrepancy between theory on workplace learning and actual workplace learning-related developments in…

  19. How to Fix Our Schools: It's More Complicated, and More Work, than the Klein-Rhee "Manifesto" Wants You to Believe. EPI Issue Brief #286

    ERIC Educational Resources Information Center

    Rothstein, Richard

    2010-01-01

    Joel Klein, chancellor of the New York City public school system, and Michelle Rhee, who resigned October 13 as Washington, D.C. chancellor, published a "manifesto" in the "Washington Post" claiming that the difficulty of removing incompetent teachers "has left our school districts impotent and, worse, has robbed millions of children of a real…

  20. What Great Coaches Do Differently: 11 Elements of Effective Coaching

    ERIC Educational Resources Information Center

    Haworth, Rob; Whitaker, Todd

    2010-01-01

    Why do some athletic coaches succeed every season while others suffer loss after loss? This book describes the beliefs, behaviors, and attitudes of great athletic coaches. Where do they focus their attention? How do they spend their time and energy? And how can others gain the same advantages? Here, Rob Haworth and Todd Whitaker describe the…

  1. Multiple Metaphors for a Singular Idea.

    ERIC Educational Resources Information Center

    Cairns, Robert B.

    1991-01-01

    Evaluates the epigenetic landscape metaphor in light of behavioral development. Cites two common errors in integrated models of behavior and biology: (1) fixing behavior as structure, thereby robbing it of dynamics and plasticity; and (2) assuming that a single optimal trajectory applies to development of organisms or systems. (BC)

  2. Stage 2--Information Seeking Strategies

    ERIC Educational Resources Information Center

    Elsenberg, Michael B.

    2005-01-01

    A brief overview of one Big6 stage by Mike Eisenberg, followed by articles by two exemplary Big6 teachers, Barbara Jansen and Rob Darrow, offering practical uses of the Big6 in elementary and secondary situations is presented. The two-part nature of information seeking strategies that includes brainstorming and choosing is emphasized.

  3. Beyond the Universities: The New Higher Education. Monitoring Change in Education.

    ERIC Educational Resources Information Center

    Mitchell, Philip, Ed.

    This book explores the expansion of higher education in the United Kingdom during the past 50 years and the coordination of university and further and distance education. The following 12 chapters are included: "Patterns of HE/FE [Higher Education/Further Education] Collaboration" (Tony Lewis, Rob Allen); "Student and Staff Perceptions of Higher…

  4. Overcoming Obstacles to Education: The Experience of Women University Students Diagnosed with Attention-Deficit/Hyperactivity Disorder.

    ERIC Educational Resources Information Center

    Dwyer, Sonya Corbin

    2000-01-01

    A hermeneutic phenomenological methodology was used to explore the experience of eight women university students diagnosed with attention deficit hyperactivity disorder. Two themes describing obstacles to their education - "robbed of time" and "thoughts like a rubber ball" - were identified. Discusses strategies and treatment issues and…

  5. Is Interdisciplinarity Old News? A Disciplined Consideration of Interdisciplinarity

    ERIC Educational Resources Information Center

    Barrett, Brian D.

    2012-01-01

    This paper draws on the theory of Basil Bernstein and on more recent applications of it by Rob Moore, John Beck and Michael Young to respond to recent calls for the replacement of discipline-based university faculties and departments with "problem-based" curricula and programmes of study. It considers, particularly, the potential consequences of…

  6. Regaining a Lost Heritage

    ERIC Educational Resources Information Center

    Coleman, Toni

    2007-01-01

    Increasingly, Blacks are turning to science and not assumptions to put "Africa" back in "African-American." The eagerness to reconnect is understandable. People robbed of their history innately want to know where they come from. Blacks are now using DNA testing to determine their African lineage. Veteran genealogists say the PBS special, "African…

  7. It Makes You Think: Learning Together. Think Global Thinkpiece Series

    ERIC Educational Resources Information Center

    Bowden, Rob

    2015-01-01

    In this thinkpiece Rob Bowden argues that an East meets West project points the way for global learning to be truly transformative. The project has a simple premise--that there is much to be learned by bringing Eastern and Western perspectives and pedagogies together and that such a process not only nurtures a global learning disposition…

  8. Fostering Resilience in Children Exposed to Domestic Violence: Practical Strategies EC Staff Can Put into Action

    ERIC Educational Resources Information Center

    Stephens, Karen

    2010-01-01

    Children enmeshed in violence don't experience a relaxed, predictable, or trusting home life. In fact, children exposed to home violence often experience symptoms of post-traumatic stress disorder (PTSD) just as adults do after enduring violence. Domestic violence robs children of their childhood. And while early childhood staff can't erase the…

  9. 75 FR 55973 - Safety Zone; Illinois River, Mile 000.5 to 001.5

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... unless specifically authorized by the Captain of the Port Upper Mississippi River or a designated... rule, call or e-mail Lieutenant (LT) Rob McCaskey, Sector Upper Mississippi River Response Department... property from the hazards associated with the fireworks. The Captain of the Port Upper Mississippi...

  10. Appropriating Professionalism: Restructuring the Official Knowledge Base of England's "Modernised" Teaching Profession

    ERIC Educational Resources Information Center

    Beck, John

    2009-01-01

    The present paper examines efforts by government and government agencies in England to prescribe and control the knowledge base of a teaching profession that has, under successive New Labour administrations since 1997, been subjected to "modernisation". A theoretical framework drawn from aspects of the work of Basil Bernstein, and of Rob Moore and…

  11. Time to Learn. Research Points. Volume 5, Issue 2, Winter 2007

    ERIC Educational Resources Information Center

    Rangel, Elizabeth S.

    2007-01-01

    Calls for more school instructional time are coming from multiple quarters. Academic standards and frequent assessments have changed the nature, but not the length, of the instructional day. Schools find themselves "robbing Peter to pay Paul," taking time from the arts, recess, and physical education to give to reading and math, subjects that…

  12. Using Online Storybooks to Build Comprehension

    ERIC Educational Resources Information Center

    Lacina, Jan; Mathews, Sarah

    2012-01-01

    "If we teach today as we taught yesterday, then we rob our children of tomorrow" (Dewey, 1916). Dewey's words are still relevant today as educators across the world consider how to best connect the print-based literacies of the past to the technologically based literacies of the present. Dewey's advice of re-envisioning how to best teach children…

  13. 77 FR 66519 - National Alzheimer's Disease Awareness Month, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... thirty-seventh. (Presidential Sig.) [FR Doc. 2012-27196 Filed 11-5-12; 8:45 am] Billing code 3295-F3 ... Documents#0;#0; ] Proclamation 8897 of November 1, 2012 National Alzheimer's Disease Awareness Month, 2012... country confront the tragic realities of Alzheimer's disease--an irreversible, fatal illness that robs...

  14. 3 CFR 8591 - Proclamation 8591 of October 29, 2010. National Alzheimer's Disease Awareness Month, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Alzheimer's Disease Awareness Month, 2010 8591 Proclamation 8591 Presidential Documents Proclamations Proclamation 8591 of October 29, 2010 Proc. 8591 National Alzheimer's Disease Awareness Month, 2010By the President of the United States of America A Proclamation Alzheimer’s disease tragically robs individuals...

  15. Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine "asmachilca"

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Asmachilca is a Peruvian medicinal herb preparation ostensibly derived from Eupatorium gayanum Wedd. = Aristeguietia gayana (Wedd.) R.M. King & H. Rob. (Asteraceae: Eupatorieae). Decoctions of the plant have a reported bronchodilation effect that is purported to be useful in the treatment of respir...

  16. Commencing the Rhizome: Towards a Minor Philosophy of Education

    ERIC Educational Resources Information Center

    Gregoriou, Zelia

    2004-01-01

    In "The Postmodern Explained," a pedagogical sequel to "The Postmodern Condition," Jean Francois Lyotard reports on the domination of thought by the principle of realism. Lyotard speaks of a demand that threatens to totalize experience, to reduce language to Newspeak, to rob thinking of its childhood and pedagogy of its philosophical moment. It is…

  17. The Power of Peers

    ERIC Educational Resources Information Center

    Traver, Rob

    2016-01-01

    "Students are naturally inclined to watch one another, to make suggestions and support their peers, to avoid mistakes, to copy what works and modify what doesn't, and to learn from one another," writes Rob Traver in this article. To prove his point, Traver brings readers into three classrooms where teachers tap into students' intrinsic…

  18. Asymmetrical disassortative pollination in a distylous primrose: the complementary roles of bumblebee nectar robbers and syrphid flies.

    PubMed

    Zhu, Xing-Fu; Jiang, Xian-Feng; Li, Li; Zhang, Zhi-Qiang; Li, Qing-Jun

    2015-01-12

    Heterostyly is a floral polymorphism characterized by reciprocal herkogamy maintained through high levels of mating between morphs, serviced by appropriate pollinators. We studied how differential efficiency and abundance of distinct pollinators affect plant female reproduction in self- and intra-morph incompatible distylous Primula secundiflora. Bumblebees and syrphid flies were found to be the most abundant floral visitors. Bumblebees frequently exhibited nectar-robbing behavior. Because the robbing holes were always situated between the high- and low-level organs on both morphs, nectar-robbing bumblebees only pollinated S-styled flowers. L-styled flowers set four times as many seeds as did S-styled flowers after being visited by pollen-collecting syrphid flies. The natural female fecundity and the magnitude of pollen limitation varied between the morphs within populations because of the mosaic distribution of nectar-robbing bumblebees and syrphid flies. L-styled flowers and S-styled flowers set the same number of seeds after supplemental hand pollination, indicating equivalent female reproductive potential. We suggest that bumblebee nectar robbers and syrphid flies play an important role in sustaining the floral dimorphism of heterostyly in P. secundiflora because of their complementary roles in the pollination system.

  19. Concepts Shaping Juvenile Justice

    ERIC Educational Resources Information Center

    White, Rob

    2008-01-01

    Rob White's paper explores ways in which community building can be integrated into the practices of juvenile justice work. He provides a model of what can be called "restorative social justice", one that builds upon the juvenile conferencing model by attempting to fuse social justice concerns with progressive juvenile justice practices.

  20. Humans, Sharks and the Shared Environment in the Contemporary Eco-Doc

    ERIC Educational Resources Information Center

    Hughes, Helen

    2011-01-01

    Focussing on the film "Sharkwater" directed by Rob Stewart (2006), this article discusses formal interpretive aspects of recent environmental documentaries which are intended to raise awareness about environmental issues. It is argued that contemporary environmental documentaries seek to persuade audiences to protect the shared physical…

  1. The Athletae Dei: Missing the Meaning of Sport.

    ERIC Educational Resources Information Center

    Hoffman, Shirl J.

    By making virtue of ascesis or self-discipline in their sport, the athlete evangelists (the "athletae-Dei"), unwittingly rob sport of its fundamental theological significance. These proponents of an evangelical brand of protestant theology have shifted drastically from an anti-sport stance of a century ago to a position that not only embraces…

  2. A man of universal interests

    NASA Astrophysics Data System (ADS)

    Sakharov, Andrei

    1988-02-01

    The death of Ya. B. Zel'dovich robs physics of one of its guiding lights of the twentieth century. Here Andrei Sakharov reflects on his life and his science, while on p. 673 appears a report of two meetings written by ZeVdovich, in collaboration with A. A. Starobinskii, shortly before his death.

  3. 77 FR 60450 - Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ..., Matthew L. Kruger, Mary Kubiak, Lev J. Langlois, Joseph E. Lederer, Calvin M. Legomsky, Stephen H. Lew... Singleton, Kathy Smiley, Dennis Smislova, Melissa Smith, A.T. Smith, Douglas Smith, Eric T. ] Smith, Gordon... Thomas, Rob C. Tierney, MaryAnn E. Tomchek, Debra Tomsheck, James F. Torrence, Donald Triner,...

  4. Grief Casualties on Skid Row.

    ERIC Educational Resources Information Center

    Hughes, Cornelius; Fleming, Dagmar

    1991-01-01

    Case study research in shelter for homeless men revealed small, but notable, minority suffering from unresolved grief resulting from death of spouse, child, parent, or other immediate family member, or to painful divorce. Failure to cope with grief appeared to have robbed them of will to maintain their social standing. (Author/NB)

  5. Identifying, Confronting and Disrupting Stereotypes: Role on the Wall in an Intergenerational LGBTQ Applied Theatre Project

    ERIC Educational Resources Information Center

    Houseal, Jennifer; Ray, Kevin; Teitelbaum, Sherry

    2013-01-01

    In New York City, LGBTQ people from different generations have had few opportunities to connect. They have splintered into age-segregated micro-communities, robbing them of opportunities to weave a common history and share strategies that community members have used to survive and thrive. "Bridging the Gap" was a community-based intergenerational…

  6. Narrative Chance. Postmodern Discourse on Native American Indian Literatures.

    ERIC Educational Resources Information Center

    Vizenor, Gerald, Ed.

    Native American literary works have often been ignored by serious critics or examined by social scientists in ways that rob them of their effectiveness as works of art. The emphasis of postmodern theory on the creative power of language, on narrative discourse, and on signs and semiotics allows an original and perceptive approach to Native…

  7. A Mean Wink at Authenticity: Chinese Images in Disney's "Mulan."

    ERIC Educational Resources Information Center

    Mo, Weimin; Shen, Wenju

    2000-01-01

    Offers a critique from two Chinese educators with regard to the historical, cultural, linguistic, and artistic authenticity of Disney's animated film "Mulan." Argues that the filmmakers robbed the original story of its soul and "ran over Chinese culture with the Disney bulldozer," imposing mainstream cultural beliefs and values. (SR)

  8. THE PHYSICAL AND CHEMICAL CHARACTERIZATION OF THE EMISSIONS FROM A RESIDENTIAL OIL BOILER

    EPA Science Inventory

    The toxicity of emissions from the combustion of home heating oil and the use of residential oil boilers (ROB) is an important health concern. Yet scant physical and chemical information about the emissions from this source are available for dispersion, climate, and source-recep...

  9. Don't Bother Me, I'm Reading: Graphic Nonfiction for Middle Schoolers

    ERIC Educational Resources Information Center

    Gutierrez, Peter

    2008-01-01

    This article offers a savvy guide to the best graphic nonfiction books for middle schoolers. These include: "Ronald Reagan: A Graphic Biography" by Andrew Hefler; "Clan Apis" by Jay Hosler; and "Corpses and Skeletons: The Science of Forensic Anthropology" by Rob Shone.

  10. Robert K. Clifton 1964-2002

    NASA Astrophysics Data System (ADS)

    Butterfield, J.; Halvorson, H.

    Rob Clifton, the editor of this journal, passed away on 31 July 2002, after a valiant battle with cancer over the previous 14 months, and just after his 38th birthday. He was a researcher of enormous talent and energy, an outstanding teacher and colleague.

  11. 77 FR 31064 - Petition for Exemption; Summary of Petition Received

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www..., except Federal holidays. FOR FURTHER INFORMATION CONTACT: Robert Hawks, Office of the Chief Counsel...-7143; email: rob.hawks@faa.gov . This notice is published pursuant to 14 CFR 11.85. Issued...

  12. 75 FR 9017 - Orders Limiting Scheduled Operations at John F. Kennedy International Airport, LaGuardia Airport...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... CFR Sec. 93.227 (DCA); 74 FR 51648 (Oct. 7, 2009) (EWR); 74 FR 51650 (Oct. 7, 2009) (JFK); 74 FR 51653.... FOR FURTHER INFORMATION CONTACT: Robert Hawks, Office of the Chief Counsel, Regulations Division...- 7143; e-mail: rob.hawks@faa.gov . SUPPLEMENTARY INFORMATION: Background Multiple snowstorms in...

  13. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    ERIC Educational Resources Information Center

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  14. TIFS/FL5 - 2nd Asheville deployment

    NASA Technical Reports Server (NTRS)

    1999-01-01

    TIFS/FL5 - 2nd Asheville deployment. People in photograph include: Charlie Peacock, Randy Bailey, Paul Deppe, Mike Reagan, Mike Norman, Rob Rivera, Paul Schifferle, Russ Parrish, Trey Auther, Lou Glaab, Dave McLuer, Mike Parrag, and Lynda Kramer.

  15. Second Language Vocabulary Acquisition from Language Input and from Form-Focused Activities

    ERIC Educational Resources Information Center

    Laufer, Batia

    2009-01-01

    Interest in L2 vocabulary learning and teaching started long before the nineteen-eighties (for references to earlier studies, see Rob Waring's database http://www1.harenet.ne.jp/~waring/vocab/vocrefs/vocref.html) but it declined with the advent of generative linguistics to the point of discrimination and neglect (Meara 1980). In 1986, I argued…

  16. Chaos on Sesame Street: Does This Carnival of Images Help Students Read?

    ERIC Educational Resources Information Center

    Healy, Jane M.

    1990-01-01

    The rapid, disjointed, and vivid style of Sesame Street may impede rather than promote progress toward literacy and the development of voluntary attention. It robs children of the ability to create mental pictures. Contends that it is a failure as an instructional medium. (DM)

  17. Gathering recognizes contributions of former Section President

    NASA Astrophysics Data System (ADS)

    Mac Niocaill, Conall; van der Pluijm, Ben; Torsvik, Trand

    To celebrate the sixtieth birthday of Rob Van derVoo, AGU's President and President-elect of its Geomagnetism and Paleomagnetism Section, 1988-1992, a workshop was recently held in an intimate conference setting in Ann Arbor, Michigan. The purpose was to celebrate Rob's many contributions to the fields of paleomagnetism and tectonics as he reached this milestone. Some 30 people attended and were treated to 18 presentations, many of which have recently been published or are currently in review for a special issue in his honor. While great emphasis was placed on paleomagnetism as the only quantitative tool for generating paleogeographic reconstructions for pre-Mesozoic time, a recurring theme within the meeting was the integration of paleomagnetic results with those from other disciplines—a hallmark of Rob's research efforts at the University of Michigan. The meeting also provided an opportunity for students and colleagues of Rob's to indulge in more “speculative” ideas, and the presentations were accompanied by wide-ranging and “spirited” discussions during both the “formal” sessions and the highly enjoyable evening social activities.

  18. Building a Foundation for Success: How Authorizers Can Help Schools with the Facilities Challenge. Authorizer Issue Brief. Number 2

    ERIC Educational Resources Information Center

    Halsband, Robin; Hassel, Bryan C.

    2004-01-01

    One of the single biggest challenges for a charter school is securing financing for an adequate facility. While a stellar building provides no guarantee that a school will be a success, having adequate facilities that at least meet the needs of an academic program without robbing the budget can go a long way toward creating an environment…

  19. Workplace Education: The Changing Landscape.

    ERIC Educational Resources Information Center

    Taylor, Maurice C., Ed.

    The 23 chapters of this book are as follows: "A Framework for Developing Partnerships" (Wendy M. Doughty); "Partnership Building in Nova Scotia" (Marjorie Davison, Paul Temple); "What Makes a Successful Workplace Education Partnership?" (Rob Despins et al.); "Building Linkages in Large Organizations: The Syncrude Canada Ltd. Experience" (Lloyd…

  20. 45 CFR 1706.170 - Compliance procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency... Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES...

  1. A Commentary on"'Sustainability and Accounting Education: The Elephant in the Classroom"

    ERIC Educational Resources Information Center

    Laine, Matias

    2013-01-01

    In this commentary Matias Laine reviews the vivid paper written by Rob Gray (2013) who discusses his view of how sustainability is positioned within accounting education and how accounting educators can directly approach sustainability in their teaching. Laine notes many of the aspects that Gray considers important reflect the starting point of…

  2. 77 FR 73889 - National Pearl Harbor Remembrance Day, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... December 7, 1941, our Nation suffered one of the most devastating attacks ever to befall the American people. In less than 2 hours, the bombs that rained on Pearl Harbor robbed thousands of men, women, and... bright--whether in the memory of those who knew them, the spirit of service that guides our men and...

  3. 45 CFR 1706.170 - Compliance procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The...

  4. Use of PCR analysis for identification of species and genus of Septoria on grain crops

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Research on methods for molecular-genetic testing of the Septoria pathogens of wheat was initiated. Two species of septoria were studied: Septoria tritici Rob. et Desm., and Stagonospora nodorum [Berk] Castellani and E.G. Germano. Different protocols for extraction of DNA were applied; the best meth...

  5. Influences of Television on Children's Behavior: Implications for War and Peace.

    ERIC Educational Resources Information Center

    Frost, Joe L.

    Television is robbing children of their childhood. Moreover, it is destroying children's developing symbolic processes, and inhibiting their creativity and play. Television has remarkable influence over children's behavior. At this point, it is plausible to hypothesize linkages between television viewing and numerous social problems involving…

  6. An Ethnographic Study of the Kids on the Streets of Fortaleza, Brazil: Family, School, Peer and Community Life, Self-Concept.

    ERIC Educational Resources Information Center

    Campos Monteiro, Julieta M.; And Others

    Depiction of the problem of children living in the streets in third world countries emphasizes the extent to which they are victims (as statistics have shown them as numbers on the streets or killed by "death squads") or victimizers who affect an economy (e.g., by robbing tourists). Both descriptions suggest that one-dimensional portrait of the…

  7. 76 FR 28421 - Proposed Information Collection; Comment Request; Marine Recreational Fisheries Statistics Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Marine... collection instrument(s) and instructions should be directed to Rob Andrews, NOAA, National Marine Fisheries... INFORMATION: I. Abstract This request is for a revision of a current information collection....

  8. The Student Aid Gauntlet: Making Access to College Simple and Certain. Final Report of the Special Study of Simplification of Need Analysis and Application for Title IV Aid

    ERIC Educational Resources Information Center

    Stone, Jeneva E., Ed.

    2005-01-01

    Millions of students and adult learners who aspire to college are overwhelmed by the complexity of student aid. Uncertainty and confusion rob them of its significant benefits. Rather than promote access, student aid often creates a series of barriers--a gauntlet that the poorest students must run to get to college. Replacing complexity with a…

  9. Automating Libraries: The Major Mistakes Vendors Are Likely to Make.

    ERIC Educational Resources Information Center

    Library Hi Tech, 1985

    1985-01-01

    Five prominent consultants--Richard Boss, Susan Baerg Epstein, Rob McGee, Joseph Matthews, James E. Rush--discuss the most common mistakes vendors make in implementing library automated systems. Suggestions are made for correcting basic problems relating to identification of library needs, communications, delivery dates, inadequate systems, and…

  10. 45 CFR 1706.170 - Compliance procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The...

  11. 45 CFR 1706.170 - Compliance procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The...

  12. Bullying in Elementary School: An American Perspective

    ERIC Educational Resources Information Center

    Conn, Kathleen

    2013-01-01

    Bullying in elementary schools is a recognized and widespread occurrence that threatens to rob children of their childhood. Part I of this commentary describes existing scientifically-based research on the nature, extent and effects of the phenomenon on children in United States schools. Part II analyzes the effectiveness of bullying prevention…

  13. Treatment of Neurosensory Disorders Improves Psychological Well-Being in Children

    ERIC Educational Resources Information Center

    Bohlander, Robert

    2009-01-01

    Psychological well-being is the ultimate "quality of life" measure. The presence of a neurosensory disorder (NSD) in a child, such as ADD, ADHD, Asperger's syndrome, or autism, can rob the child of psychological well-being, or hamper the growth of well-being as the child develops. Fortunately, treatment of NSDs can remove obstacles to the…

  14. A new extra-vertebral treatment model for incomplete spinal cord injuries.

    PubMed

    Krishnan, R V

    2003-02-01

    Advances made in recent times in spinal cord injury repair research will soon take us toward a cure in paraplegics. But what are the prospects for quadriplegics? Certain fundamental issues make treatment approaches to quadriplegia different and difficult. Injury at cervical region poses additional problems for any surgical intervention with life-threatening risks of i) endangering respiratory function, ii) cavitation, cysts, and syringomyelia formation extending cephalad to the injury, and iii) mid-lower cervical injuries, lower motor neuron death, and the resultant degeneration of brachial plexus axons would still leave the upper limbs denervated and paralyzed even as treatment procedures might successfully salvage the lower limbs. With these apparently insurmountable impediments in quadriplegic cord repair, it would be wise to turn to alternative treatment strategies. Conventional treatment models since the days of Ralph Gerard (1940) have all used intra-vertebral procedures. We present here a plausible extra-vertebral repair model suitable for incomplete cord injuries at cervical, thoracic, and lumbar levels. The procedure consists of identifying the extent of viable grey-white matter in the injured area and to utilize it efficiently as a "neural tissue bridge." Next, labile state is induced by using botulinum toxin/colchicine (Krishnan, 1983, 1991; Krishnan et al., 2001 a,b) and Ca+ channel blockers in the motorsensory nerve terminals of polisegmentally innervated skeletal muscles that "bridge" the injured cord segments. This would retrogradely induce a redundant state of intra-spinal growth of nerve terminals and new synaptic connections within those viable neural tissues, as well as promote effective relinking of the injured cord ends and enhance motor-sensory recovery. PMID:12751430

  15. The Alteration of Neonatal Raphe Neurons by Prenatal-Perinatal Nicotine. Meaning for Sudden Infant Death Syndrome.

    PubMed

    Cerpa, Verónica J; Aylwin, María de la Luz O; Beltrán-Castillo, Sebastián; Bravo, Eduardo U; Llona, Isabel R; Richerson, George B; Eugenín, Jaime L

    2015-10-01

    Nicotine may link maternal cigarette smoking with respiratory dysfunctions in sudden infant death syndrome (SIDS). Prenatal-perinatal nicotine exposure blunts ventilatory responses to hypercapnia and reduces central respiratory chemoreception in mouse neonates at Postnatal Days 0 (P0) to P3. This suggests that raphe neurons, which are altered in SIDS and contribute to central respiratory chemoreception, may be affected by nicotine. We therefore investigated whether prenatal-perinatal nicotine exposure affects the activity, electrical properties, and chemosensitivity of raphe obscurus (ROb) neurons in mouse neonates. Osmotic minipumps, implanted subcutaneously in 5- to 7-day-pregnant CF1 mice, delivered nicotine bitartrate (60 mg kg(-1) d(-1)) or saline (control) for up to 28 days. In neonates, ventilation was recorded by head-out plethysmography, c-Fos (neuronal activity marker), or serotonin autoreceptors (5HT1AR) were immunodetected using light microscopy, and patch-clamp recordings were made from raphe neurons in brainstem slices under normocarbia and hypercarbia. Prenatal-perinatal nicotine exposure decreased the hypercarbia-induced ventilatory responses at P1-P5, reduced both the number of c-Fos-positive ROb neurons during eucapnic normoxia at P1-P3 and their hypercapnia-induced recruitment at P3, increased 5HT1AR immunolabeling of ROb neurons at P3-P5, and reduced the spontaneous firing frequency of ROb neurons at P3 without affecting their CO2 sensitivity or their passive and active electrical properties. These findings reveal that prenatal-perinatal nicotine reduces the activity of neonatal ROb neurons, likely as a consequence of increased expression of 5HT1ARs. This hypoactivity may change the functional state of the respiratory neural network leading to breathing vulnerability and chemosensory failure as seen in SIDS.

  16. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits.

    PubMed

    Liu, Chun; Wang, Sheng-Jie; Zhang, Qian; Shao, Yi-Xiang

    2015-01-01

    In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB.

  17. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits.

    PubMed

    Liu, Chun; Wang, Sheng-Jie; Zhang, Qian; Shao, Yi-Xiang

    2015-01-01

    In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB. PMID:25319758

  18. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits

    PubMed Central

    Liu, Chun; Wang, Sheng-Jie; Zhang, Qian; Shao, Yi-Xiang

    2014-01-01

    In-feed Medication has been used for a long time to prevent coccidiosis, a worldwide protozoal disease in rabbits. Florfenicol (FFC) has been widely used in veterinary clinics for bacterial diseases treatment. Therefore, the use of combinations of coccidiostats with FFC in rabbits is common. In the present study, we aimed to evaluate the effect of three coccidiostats, sulfaquinoxaline (SUL), robenidine (ROB), and toltrazuril (TOL), as feed additives on the pharmacokinetic profile of FFC in rabbits. The disposition kinetics of FFC in rabbits were investigated after a single intravenous injection (25 mg/kg) in rabbits fed anticoccidial-free diets or feeds containing SUL (250 ppm), ROB (66 ppm), or TOL (2 ppm), respectively, for 20 days. Plasma FFC concentrations were determined by the high performance liquid chromatography (HPLC) method. The pharmacokinetic parameters of FFC were analyzed using a non-compartmental analysis based on the statistical moment theory. The results demonstrated that ROB feeding resulted in an obvious decrease in plasma FFC level as compared with anticoccidial-free feeding. The terminal elimination half-life (t1/2z), area under the concentration–time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with ROB. However, we did not find that SUL or TOL feeding had any effect on the pharmacokinetic profile of FFC. Our findings suggested that more attention should be paid to the use of FFC in rabbits supplemented with ROB. PMID:25319758

  19. Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.

    PubMed

    Notoya, Michitaka; Nishimura, Hiroyuki; Woo, Je-Tae; Nagai, Kazuo; Ishihara, Yoko; Hagiwara, Hiromi

    2006-03-18

    The effects of curcumin, which is an important constituent of rhizomes of the plant Curcuma longa Linn, on the metabolism of osteoblasts were examined in cultures of rat calvarial osteoblastic cells (ROB cells). The proliferation of cells was markedly inhibited upon exposure of cells to curcumin at 5x10(-6) to 1x10(-5) M. Curcumin at 1x10(-5) M did not induce apoptosis in ROB cells but arrested cells at the G1 phase of the cell cycle. In addition, curcumin stimulated the expression of mRNA for p21(WAF1/CIP1), which inhibits the activity of cyclin-dependent kinases, and inhibited the phosphorylation of histone H1. Furthermore, curcumin reduced the rate of deposition of calcium and the formation of mineralized nodules. Our results indicate that curcumin might inhibit the proliferation and mineralization of osteoblastic cells through the expression of p21(WAF1/CIP1). PMID:16476424

  20. Middle-ear microsurgery simulation to improve new robotic procedures.

    PubMed

    Kazmitcheff, Guillaume; Nguyen, Yann; Miroir, Mathieu; Péan, Fabien; Ferrary, Evelyne; Cotin, Stéphane; Sterkers, Olivier; Duriez, Christian

    2014-01-01

    Otological microsurgery is delicate and requires high dexterity in bad ergonomic conditions. To assist surgeons in these indications, a teleoperated system, called RobOtol, is developed. This robot enhances gesture accuracy and handiness and allows exploration of new procedures for middle ear surgery. To plan new procedures that exploit the capacities given by the robot, a surgical simulator is developed. The simulation reproduces with high fidelity the behavior of the anatomical structures and can also be used as a training tool for an easier control of the robot for surgeons. In the paper, we introduce the middle ear surgical simulation and then we perform virtually two challenging procedures with the robot. We show how interactive simulation can assist in analyzing the benefits of robotics in the case of complex manipulations or ergonomics studies and allow the development of innovative surgical procedures. New robot-based microsurgical procedures are investigated. The improvement offered by RobOtol is also evaluated and discussed.

  1. Experimentation with GRACE, the Generic Model of Emotions For Computational Applications

    NASA Astrophysics Data System (ADS)

    Dang, Thi-Hai-Ha; Duhaut, Dominique

    2009-03-01

    In this paper, we present a model of emotions that we proposed in EmotiRob project. First of all, we make a comparison of recent models of emotions and show that our model is generic in basing on the theories of emotions of Ortony et al., of Lazarus, of Scherer and then the personality theory of Meyers-Brigg and Meyers. Then, we present our experimentation with the first instance of the model and its result to validate our work.

  2. ompW is cooperatively upregulated by MarA and SoxS in response to menadione

    PubMed Central

    Collao, B.; Morales, E. H.; Gil, F.; Calderón, I. L.

    2013-01-01

    OmpW is a minor porin whose biological function has not been clearly defined. Evidence obtained in our laboratory indicates that in Salmonella enterica serovar Typhimurium the expression of OmpW is activated by SoxS upon exposure to paraquat and it is required for resistance. SoxS belongs to the AraC family of transcriptional regulators, like MarA and Rob. Due to their high structural similarity, the genes under their control have been grouped in the mar/sox/rob regulon, which presents a DNA-binding consensus sequence denominated the marsox box. In this work, we evaluated the role of the transcription factors MarA, SoxS and Rob of S. enterica serovar Typhimurium in regulating ompW expression in response to menadione. We determined the transcript and protein levels of OmpW in different genetic backgrounds; in the wild-type and Δrob strains ompW was upregulated in response to menadione, while in the ΔmarA and ΔsoxS strains the induction was abolished. In a double marA soxS mutant, ompW transcript levels were lowered after exposure to menadione, and only complementation in trans with both genes restored the positive regulation. Using transcriptional fusions and electrophoretic mobility shift assays with mutant versions of the promoter region we demonstrated that two of the predicted sites were functional. Additionally, we demonstrated that MarA increases the affinity of SoxS for the ompW promoter region. In conclusion, our study shows that ompW is upregulated in response to menadione in a cooperative manner by MarA and SoxS through a direct interaction with the promoter region. PMID:23393149

  3. Vantage Theory and Linguistic Relativity

    ERIC Educational Resources Information Center

    Allan, Keith

    2010-01-01

    Rob MacLaury's Vantage Theory, VT, models the way in which a cognizer constructs, recalls, uses, and modifies a category in terms of point of view or vantage. Alongside of VT, there is place for the kind of semantic specification found in the lexicon. VT2 [Allan, Keith, 2002. "Vantage theory, VT2, and number." "Language Sciences" 24(5-6), 679-703…

  4. TEM-1-encoding small plasmids impose dissimilar fitness costs on Haemophilus influenzae and Haemophilus parainfluenzae.

    PubMed

    Søndergaard, Annette; Lund, Marianne; Nørskov-Lauritsen, Niels

    2015-12-01

    Only two beta-lactamases, TEM-1 and ROB-1, have been observed in Haemophilus influenzae, while four different TEM but no ROB enzymes have been found in Haemophilus parainfluenzae. In order to investigate the mechanisms behind the dissemination of small beta-lactamase-encoding plasmids in H. influenzae and H. parainfluenzae, we assessed the fitness cost of three TEM-1- (pPN223, pA1209, pA1606), one TEM-15- (pSF3) and one ROB-1-bearing (pB1000) plasmid when expressed in either bacterial species. All plasmids were stable in H. influenzae and H. parainfluenzae except pB1000, which showed on average (sample mean) 76% curing in H. parainfluenzae after 5  days of subculture. Competition assays between isogenic strains with and without plasmid showed no competitive disadvantage of pPN223 and pA1606 in H. influenzae, or of pA1209 in H. parainfluenzae. In contrast, pSF3 and pB1000 were associated with significant competitive disadvantages in both species. Some of the competitive disadvantages may be related to differences in plasmid copy number and mRNA expression of the beta-lactamase genes, as revealed by quantitative PCR analysis. In conclusion, plasmids encoding TEM beta-lactamases isolated from H. influenzae and H. parainfluenzae can be stably transferred between species. The fast curing of pB1000 in H. parainfluenzae observed in this study correlates to the fact that ROB-1 has never been reported for this species. TEM-1-encoding plasmids are associated with the lowest level of fitness cost, but different TEM-1 plasmids confer different levels of fitness cost on the two hosts.

  5. Constructing and Experiencing Boyhoods in Research in London

    ERIC Educational Resources Information Center

    Pattman, Rob; Frosh, Stephen; Phoenix, Ann

    2005-01-01

    When Rob was about 14-years-old, at an all male boarding school, he was so glad that he did not have a tiny penis like another boy who was called girl. He was popular because he was good at sport, missed his mum and dog terribly but never showed it (except a little to his mum and dog) and talked a lot about girls he fancied. These memories were…

  6. The levels of HDAC1 and thioredoxin1 are related to the death of mesothelioma cells by suberoylanilide hydroxamic acid.

    PubMed

    You, Bo Ra; Park, Woo Hyun

    2016-05-01

    Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) and thioredoxin (Trx). While 1 µM SAHA inhibited cell growth in Phi and ROB cells at 24 h, it did not affect the growth in ADA and Mill cells. Notably, the level of HDAC1 was relatively overexpressed among Phi, REN and ROB cells. SAHA induced necrosis and apoptosis, which was accompanied by the cleavages of PARP and caspase-3 in Phi cells. This agent also increased the loss of mitochondrial membrane potential (MMP, ΔΨm) in Phi cells. All the tested caspase inhibitors attenuated apoptosis in SAHA-treated Phi cells whereas HDAC1 siRNA enhanced the apoptotic cell death. SAHA increased intracellular ROS levels including O2•- in Phi cells. N-acetyl cysteine (NAC) and vitamin C (Vit.C) significantly reduced the growth inhibition and death of Phi cells caused by SAHA. This drug decreased the mRNA and protein levels of Trx1 in Phi and ROB cells. Furthermore, Trx1 siRNA increased cell death and O2•- level in SAHA-treated Phi cells. In conclusion, SAHA selectively inhibited the growth of Phi and ROB mesothelioma cells, which showed the higher basal level of HDAC1. SAHA-induced Phi cell death was related to oxidative stress and Trx1 levels. PMID:26936390

  7. Suggestion of Raspailia (Hymeraphiopsis) septentrionalis as replacement name for Raspailia (Hymeraphiopsis) fruticosa Lehnert & Stone, 2015.

    PubMed

    Lehnert, Helmut; Stone, Robert P

    2016-01-01

    Shortly after publication of Raspailia (Hymeraphiopsis) fruticosa Lehnert & Stone, 2015 Rob Van Soest (pers. communication) noticed that this species name is a junior primary homonym of Raspailia fruticosa Dendy, 1887, now accepted as Endectyon fruticosa. According to the ICZN the published species name is unavailable and we now suggest to replace the name with Raspailia (Hymeraphiopsis) septentrionalis (holotype deposited at the Zoologische Staatssammlung München, ZSM 20150392, collection data published in Lehnert & Stone 2015). PMID:27394372

  8. Recovery from Trauma: A Look into the Process of Healing from Sexual Assault

    ERIC Educational Resources Information Center

    Skinner, Julia

    2009-01-01

    The purpose of this article is twofold. First, it is a narrative of the healing process and long-term effects of a sexual assault. But tied in with that is another aspect which I feel would be robbing my readers of a full understanding of my experience were I to exclude it. This involves these effects on an interpersonal level: an account of how…

  9. Army Precision at Central Headquarters

    ERIC Educational Resources Information Center

    Goldman, Jay P.

    2005-01-01

    William "Rob" Roberts wasn't thinking about working as a professional educator, much less running a major school system, when he decided he'd had enough of formal schooling himself at age 19. Rather, he dreamed of big adventures, flying combat aircraft for the military. When he discovered the U.S. Army didn't insist on two years of college, only…

  10. Effect of nursing home characteristics on residents' quality of life: a systematic review.

    PubMed

    Xu, Dongjuan; Kane, Robert L; Shamliyan, Tatyana A

    2013-01-01

    The association between nursing home (NH) characteristics and residents' quality of life (QOL) has not been systematically reviewed. This study synthesizes published evidence about the association between NH ownership, affiliation, location, chain membership, percentage of private rooms, facility size, and staffing with residents' QOL. We searched Medline, Web of Science, CINAHL, and Scirus for primary studies published between 1960 and March 31, 2012. We critically appraised risk of bias according to study design, QOL measurements, and adjustment for residents' characteristics. We analyzed the statistical and clinical significance, direction and magnitude of the association. From 1117 citations retrieved, we found one longitudinal quasi-experimental and 10 cross-sectional eligible studies. Variability in the NH characteristics reported and QOL measurements precluded meta-analysis. Studies with low and medium risk of bias (ROB) suggested that nonprofit NHs resulted in better QOL for residents. The low ROB study indicated that in certain QOL domains, rural facilities and facilities with a higher percentage of private rooms were associated with better self-reported resident QOL. All low and medium ROB studies found that RN, LVN/LPN and total nursing staff had no significant relationship with QOL. One longitudinal quasi-experimental study indicated that the Green House with individualized care had better QOL than conventional NHs. The available evidence does not permit strong conclusions about the association between NH characteristics and residents' QOL. The evidence does, however, raise questions about whether NH structure alone can improve residents' QOL and how residents' QOL should be measured and improved.

  11. Chicken Essence for Cognitive Function Improvement: A Systematic Review and Meta-Analysis

    PubMed Central

    Teoh, Siew Li; Sudfangsai, Suthinee; Lumbiganon, Pisake; Laopaiboon, Malinee; Lai, Nai Ming; Chaiyakunapruk, Nathorn

    2016-01-01

    Chicken essence (CE) is a popular traditional remedy in Asia, which is believed to improve cognitive functions. CE company claimed that the health benefits were proven with research studies. A systematic review was conducted to determine the cognitive-enhancing effects of CE. We systematically searched a number of databases for randomized controlled trials with human subjects consuming CE and cognitive tests involved. Cochrane’s Risk of Bias (ROB) tool was used to assess the quality of trials and meta-analysis was performed. Seven trials were included, where six healthy subjects and one subject with poorer cognitive functions were recruited. One trial had unclear ROB while the rest had high ROB. For executive function tests, there was a significant difference favoring CE (pooled standardized mean difference (SMD) of −0.55 (−1.04, −0.06)) and another with no significant difference (pooled SMD of 0.70 (−0.001, 1.40)). For short-term memory tests, no significant difference was found (pooled SMD of 0.63 (−0.16, 1.42)). Currently, there is a lack of convincing evidence to show a cognitive enhancing effect of CE. PMID:26805876

  12. Pharmacopuncture for Cancer Care: A Systematic Review

    PubMed Central

    Cheon, Soyeon; Zhang, Xiuyu; Lee, In-Seon; Cho, Seung-Hun; Chae, Younbyoung; Lee, Hyangsook

    2014-01-01

    Background. Pharmacopuncture, injection to acupoints with pharmacological medication or herbal medicine, is a new acupuncture therapy widely available in Korea and China for cancer-related symptoms. However, the evidence is yet to be clear. Objective. To determine pharmacopuncture's effectiveness on cancer-related symptoms. Methods. Eleven databases were searched for randomized controlled trials of pharmacopuncture in cancer patients. The Cochrane risk of bias (ROB) assessment tool was used for quality assessment. Results. Twenty-two studies involving 2,459 patients were included. Five trials of chemotherapy-induced nausea and vomiting (CINV) underwent meta-analysis. Pharmacopuncture significantly relieved severity of CINV compared with control group (3 trials, risk ratio (RR) 1.28, 95% confidence interval (CI) = 1.14–1.44). The frequency of CINV was also significantly reduced with pharmacopuncture (2 trials, RR 2.47, 95% CI = 2.12–2.89). Seventeen trials studied various symptoms, and in most studies, pharmacopuncture significantly relieved pain, ileus, hiccup, fever, and gastrointestinal symptoms and improved quality of life in various cancer patients. ROB was generally high. Conclusion. It may be suggested with caution that pharmacopuncture may help various symptom relief in cancer patients, but it is hard to draw a firm conclusion due to clinical heterogeneity and high ROB of the included studies, hence warranting further investigation. PMID:24899911

  13. An invasive slug exploits an ant-seed dispersal mutualism.

    PubMed

    Meadley Dunphy, Shannon A; Prior, Kirsten M; Frederickson, Megan E

    2016-05-01

    Plant-animal mutualisms, such as seed dispersal, are often vulnerable to disruption by invasive species. Here, we show for the first time how a non-ant invasive species negatively affects seed dispersal by ants. We examined the effects of several animal species that co-occur in a temperate deciduous forest-including native and invasive seed-dispersing ants (Aphaenogaster rudis and Myrmica rubra, respectively), an invasive slug (Arion subfuscus), and native rodents-on a native myrmecochorous plant, Asarum canadense. We experimentally manipulated ant, slug, and rodent access to seed depots and measured seed removal. We also video-recorded depots to determine which other taxa interact with seeds. We found that A. rudis was the main disperser of seeds and that A. subfuscus consumed elaiosomes without dispersing seeds. Rodent visitation was rare, and rodent exclusion had no significant effect on seed or elaiosome removal. We then used data obtained from laboratory and field mesocosm experiments to determine how elaiosome robbing by A. subfuscus affects seed dispersal by A. rudis and M. rubra. We found that elaiosome robbing by slugs reduced seed dispersal by ants, especially in mesocosms with A. rudis, which picks up seeds more slowly than M. rubra. Taken together, our results show that elaiosome robbing by an invasive slug reduces seed dispersal by ants, suggesting that invasive slugs can have profound negative effects on seed dispersal mutualisms.

  14. Chicken Essence for Cognitive Function Improvement: A Systematic Review and Meta-Analysis.

    PubMed

    Teoh, Siew Li; Sudfangsai, Suthinee; Lumbiganon, Pisake; Laopaiboon, Malinee; Lai, Nai Ming; Chaiyakunapruk, Nathorn

    2016-01-01

    Chicken essence (CE) is a popular traditional remedy in Asia, which is believed to improve cognitive functions. CE company claimed that the health benefits were proven with research studies. A systematic review was conducted to determine the cognitive-enhancing effects of CE. We systematically searched a number of databases for randomized controlled trials with human subjects consuming CE and cognitive tests involved. Cochrane's Risk of Bias (ROB) tool was used to assess the quality of trials and meta-analysis was performed. Seven trials were included, where six healthy subjects and one subject with poorer cognitive functions were recruited. One trial had unclear ROB while the rest had high ROB. For executive function tests, there was a significant difference favoring CE (pooled standardized mean difference (SMD) of -0.55 (-1.04, -0.06)) and another with no significant difference (pooled SMD of 0.70 (-0.001, 1.40)). For short-term memory tests, no significant difference was found (pooled SMD of 0.63 (-0.16, 1.42)). Currently, there is a lack of convincing evidence to show a cognitive enhancing effect of CE. PMID:26805876

  15. Nectar robbers pollinate flowers with sexual organs hidden within corollas in distylous Primula secundiflora (Primulaceae).

    PubMed

    Zhu, Xing-Fu; Wan, Jin-Peng; Li, Qing-Jun

    2010-12-23

    Nectar robbers are thought rarely to pollinate flowers, especially those with sexual organs hidden within corollas. In this study, we examined whether robbers pollinate flowers of distylous Primula secundiflora. Distylous plants have two floral morphs. Pin flowers have long styles and short stamens, and thrum flowers have short styles and long stamens. Flowers of P. secundiflora were commonly robbed by bumble-bees, and robbing holes were always situated between high and low sexual organs for both floral morphs. We observed that pollen grains of pin flowers were removed while thrum flowers received fresh pollen grains immediately after flowers were robbed. We manipulated flowers so that only nectar robbers could visit them. This resulted in 98 per cent of thrum flowers and 6 per cent of pin flowers setting fruit, and seed number per thrum fruit was also significantly higher than per pin fruit. Our findings suggest that nectar robbers transfer pollen from pin flowers to thrum flowers effectively, and consequently increase male fitness of the pin morph and female fitness of the thrum morph. Such asymmetrical pollen flow caused by nectar robbers may act as an important selective agent in floral fitness and evolution of distyly.

  16. An invasive slug exploits an ant-seed dispersal mutualism.

    PubMed

    Meadley Dunphy, Shannon A; Prior, Kirsten M; Frederickson, Megan E

    2016-05-01

    Plant-animal mutualisms, such as seed dispersal, are often vulnerable to disruption by invasive species. Here, we show for the first time how a non-ant invasive species negatively affects seed dispersal by ants. We examined the effects of several animal species that co-occur in a temperate deciduous forest-including native and invasive seed-dispersing ants (Aphaenogaster rudis and Myrmica rubra, respectively), an invasive slug (Arion subfuscus), and native rodents-on a native myrmecochorous plant, Asarum canadense. We experimentally manipulated ant, slug, and rodent access to seed depots and measured seed removal. We also video-recorded depots to determine which other taxa interact with seeds. We found that A. rudis was the main disperser of seeds and that A. subfuscus consumed elaiosomes without dispersing seeds. Rodent visitation was rare, and rodent exclusion had no significant effect on seed or elaiosome removal. We then used data obtained from laboratory and field mesocosm experiments to determine how elaiosome robbing by A. subfuscus affects seed dispersal by A. rudis and M. rubra. We found that elaiosome robbing by slugs reduced seed dispersal by ants, especially in mesocosms with A. rudis, which picks up seeds more slowly than M. rubra. Taken together, our results show that elaiosome robbing by an invasive slug reduces seed dispersal by ants, suggesting that invasive slugs can have profound negative effects on seed dispersal mutualisms. PMID:26830293

  17. Two-stage approach for detection and reduction of motion artifacts in photoplethysmographic data.

    PubMed

    Krishnan, Rajet; Natarajan, Balasubramaniam Bala; Warren, Steve

    2010-08-01

    Corruption of photopleythysmograms (PPGs) by motion artifacts has been a serious obstacle to the reliable use of pulse oximeters for real-time, continuous state-of-health monitoring. In this paper, we propose an automated, two-stage PPG data processing method to minimize the effects of motion artifacts. The technique is based on our prior work related to motion artifact detection (stage 1) [R. Krishnan, B. Natarajan, and S. Warren, "Analysis and detection of motion artifacts in photoplethysmographic data using higher order statistics,'' in Proc. IEEE Int. Conf. Acoust., Speech, Signal Process. (ICASSP 2008), Las Vegas, Nevada, Apr. 2008, pp. 613-616] and motion artifact reduction (stage 2) [R. Krishnan, B. Natarajan, and S. Warren, "Motion artifact reduction in photoplethysmography using magnitude-based frequency domain independent component analysis,'' in Proc. 17th Int. Conf. Comput. Commun. Network, St. Thomas, Virgin Islands, Aug. 2008, pp. 1-5]. Regarding stage 1, we present novel and consistent techniques to detect the presence of motion artifact in PPGs given higher order statistical information present in the data. We analyze these data in the time and frequency domains (FDs) and identify metrics to distinguish between clean and motion-corrupted data. A Neyman-Pearson detection rule is formulated for each of the metrics. Furthermore, by treating each of the metrics as observations from independent sensors, we employ hard fusion and soft fusion techniques presented in [Z. Chair and P. Varshney, "Optimal data fusion in multiple sensor detection systems,'' IEEE Trans. Aerosp. Electron. Syst., AES, vol. 1, no. 1, pp. 98-101, Jan. 1986] and [C. C. Lee and J. J. Chao, "Optimum local decision space partitioning for distributed detection,'' IEEE Trans. Aerosp. Electron. Syst., AES, vol. 25, no. 7, pp. 536-544, Jul. 1989], respectively, in order to fuse individual decisions into a global system decision. For stage two, we propose a motion artifact reduction method

  18. Two-stage approach for detection and reduction of motion artifacts in photoplethysmographic data.

    PubMed

    Krishnan, Rajet; Natarajan, Balasubramaniam Bala; Warren, Steve

    2010-08-01

    Corruption of photopleythysmograms (PPGs) by motion artifacts has been a serious obstacle to the reliable use of pulse oximeters for real-time, continuous state-of-health monitoring. In this paper, we propose an automated, two-stage PPG data processing method to minimize the effects of motion artifacts. The technique is based on our prior work related to motion artifact detection (stage 1) [R. Krishnan, B. Natarajan, and S. Warren, "Analysis and detection of motion artifacts in photoplethysmographic data using higher order statistics,'' in Proc. IEEE Int. Conf. Acoust., Speech, Signal Process. (ICASSP 2008), Las Vegas, Nevada, Apr. 2008, pp. 613-616] and motion artifact reduction (stage 2) [R. Krishnan, B. Natarajan, and S. Warren, "Motion artifact reduction in photoplethysmography using magnitude-based frequency domain independent component analysis,'' in Proc. 17th Int. Conf. Comput. Commun. Network, St. Thomas, Virgin Islands, Aug. 2008, pp. 1-5]. Regarding stage 1, we present novel and consistent techniques to detect the presence of motion artifact in PPGs given higher order statistical information present in the data. We analyze these data in the time and frequency domains (FDs) and identify metrics to distinguish between clean and motion-corrupted data. A Neyman-Pearson detection rule is formulated for each of the metrics. Furthermore, by treating each of the metrics as observations from independent sensors, we employ hard fusion and soft fusion techniques presented in [Z. Chair and P. Varshney, "Optimal data fusion in multiple sensor detection systems,'' IEEE Trans. Aerosp. Electron. Syst., AES, vol. 1, no. 1, pp. 98-101, Jan. 1986] and [C. C. Lee and J. J. Chao, "Optimum local decision space partitioning for distributed detection,'' IEEE Trans. Aerosp. Electron. Syst., AES, vol. 25, no. 7, pp. 536-544, Jul. 1989], respectively, in order to fuse individual decisions into a global system decision. For stage two, we propose a motion artifact reduction method

  19. Utilizing Nontraditional Data Sources for Near Real-Time Estimation of Transmission Dynamics During the 2015-2016 Colombian Zika Virus Disease Outbreak

    PubMed Central

    Santillana, Mauricio; Mekaru, Sumiko R; McGinnis, Denise P; Khan, Kamran; Brownstein, John S

    2016-01-01

    Background Approximately 40 countries in Central and South America have experienced local vector-born transmission of Zika virus, resulting in nearly 300,000 total reported cases of Zika virus disease to date. Of the cases that have sought care thus far in the region, more than 70,000 have been reported out of Colombia. Objective In this paper, we use nontraditional digital disease surveillance data via HealthMap and Google Trends to develop near real-time estimates for the basic (R0) and observed (Robs) reproductive numbers associated with Zika virus disease in Colombia. We then validate our results against traditional health care-based disease surveillance data. Methods Cumulative reported case counts of Zika virus disease in Colombia were acquired via the HealthMap digital disease surveillance system. Linear smoothing was conducted to adjust the shape of the HealthMap cumulative case curve using Google search data. Traditional surveillance data on Zika virus disease were obtained from weekly Instituto Nacional de Salud (INS) epidemiological bulletin publications. The Incidence Decay and Exponential Adjustment (IDEA) model was used to estimate R0 and Robs for both data sources. Results Using the digital (smoothed HealthMap) data, we estimated a mean R0 of 2.56 (range 1.42-3.83) and a mean Robs of 1.80 (range 1.42-2.30). The traditional (INS) data yielded a mean R0 of 4.82 (range 2.34-8.32) and a mean Robs of 2.34 (range 1.60-3.31). Conclusions Although modeling using the traditional (INS) data yielded higher R0 estimates than the digital (smoothed HealthMap) data, modeled ranges for Robs were comparable across both data sources. As a result, the narrow range of possible case projections generated by the traditional (INS) data was largely encompassed by the wider range produced by the digital (smoothed HealthMap) data. Thus, in the absence of traditional surveillance data, digital surveillance data can yield similar estimates for key transmission parameters and

  20. Inconsistency in the items included in tools used in general health research and physical therapy to evaluate the methodological quality of randomized controlled trials: a descriptive analysis

    PubMed Central

    2013-01-01

    Background Assessing the risk of bias of randomized controlled trials (RCTs) is crucial to understand how biases affect treatment effect estimates. A number of tools have been developed to evaluate risk of bias of RCTs; however, it is unknown how these tools compare to each other in the items included. The main objective of this study was to describe which individual items are included in RCT quality tools used in general health and physical therapy (PT) research, and how these items compare to those of the Cochrane Risk of Bias (RoB) tool. Methods We used comprehensive literature searches and a systematic approach to identify tools that evaluated the methodological quality or risk of bias of RCTs in general health and PT research. We extracted individual items from all quality tools. We calculated the frequency of quality items used across tools and compared them to those in the RoB tool. Comparisons were made between general health and PT quality tools using Chi-squared tests. Results In addition to the RoB tool, 26 quality tools were identified, with 19 being used in general health and seven in PT research. The total number of quality items included in general health research tools was 130, compared with 48 items across PT tools and seven items in the RoB tool. The most frequently included items in general health research tools (14/19, 74%) were inclusion and exclusion criteria, and appropriate statistical analysis. In contrast, the most frequent items included in PT tools (86%, 6/7) were: baseline comparability, blinding of investigator/assessor, and use of intention-to-treat analysis. Key items of the RoB tool (sequence generation and allocation concealment) were included in 71% (5/7) of PT tools, and 63% (12/19) and 37% (7/19) of general health research tools, respectively. Conclusions There is extensive item variation across tools that evaluate the risk of bias of RCTs in health research. Results call for an in-depth analysis of items that should be used to

  1. Electromagnetically driven, fast opening and closing gas jet valve

    NASA Astrophysics Data System (ADS)

    Krishnan, Mahadevan; Elliott, Kristi Wilson; Geddes, C. G. R.; van Mourik, R. A.; Leemans, W. P.; Murphy, H.; Clover, M.

    2011-03-01

    The design and performance are presented of an electromagnetically driven gas valve [M. Krishnan, J. Wright, and T. Ma, Proceedings of the 13th Advanced Accelerator Concepts Workshop, Santa Cruz, CA, AIP Conf. Proc. No. 1086 (AIP, New York, 2008)] that opens in <100μs, closes in <500μs, and can operate at pressures of ˜1000psia to drive supersonic nozzles. Such a valve has applications to laser-plasma accelerators, where the fast opening and closing would allow sharper edges to the flow and also allow higher rep-rate operation without loading the vacuum chamber. The valve action is effected by a flyer plate accelerated by the electromagnetic impulse of a low inductance, spiral wound, strip-line coil driven by a capacitor. Gas flows out of the valve when the seal between this flyer plate and the valve seat is broken. The electromagnetic force greatly exceeds the restoring forces provided by a spring and the gas pressure against the valve seat. Piezoresistive sensor and laser interferometer measurements of flow show that the valve opens in ˜100μs for all pressures up to 800 psia. The closing time is 500μs, set by the spring constant and mass. The prototype valve has been operated with helium at 0.5 Hz and at 500 psia for ˜1 hour at a time with no cooling.

  2. Using design methods to provide the care that people want and need.

    PubMed

    Erwin, Kim; Krishnan, Jerry A

    2016-01-01

    Kim Erwin is an Assistant Professor at IIT Institute of Design and trained in user-centered design methods, which put people at the center of any problem space so as to develop solutions that better fit their everyday lives, activities and context. Her expertise is in making complex information easier to understand and use. Her research targets communication tools and methods for collaborative knowledge construction built through shared experiences. Her book, Communicating the New: Methods to shape and accelerate innovation focuses on helping teams explore, build and diffuse critical knowledge inside organizations. Jerry Krishnan is a Professor of Medicine and Public Health, and Associate Vice President for Population Health Sciences at the University of Illinois Hospital & Health Sciences System. He pioneered the use of Analytic Hierarchy Process to elicit the expressed needs of stakeholders for research. He previously served as Chair of the US FDA Pulmonary and Allergy Drugs Advisory Committee and is a Principal Investigator in NIH and Patient Centered Outcomes Research Institute (PCORI)-funded research consortia. He chairs the US National Heart, Lung, and Blood Institute (NHLBI) Clinical Trials review committee and the PCORI Improving Healthcare Systems merit review panel.

  3. Soot scattering measurements in the visible and near-infrared spectrum

    SciTech Connect

    ZHU,JINYU; CHOI,MUN YOUNG; MULHOLLAND,GEORGE W.; GRITZO,LOUIS A.

    2000-02-08

    Scattering to extinction cross-section ratios, {rho}{sub se} were measured using the NIST Large Agglomerate Optics Facility for soot produced from ethene and acetylene laminar diffusion flames. Measurements were performed using light sources at 543.5 nm, 632.8 nm and 856 nm. The average scattering to extinction cross-section ratios for these wavelengths are equal to 0.246, 0.196, and 0.196 for ethene and 0.316, 0.230, and 0.239 for acetylene. The 856 nm measurements represent the longest wavelength for which accurate scattering measurements have been performed for soot. The size distribution and fractal properties of the two soots were determined to assess the effects of limited acceptance angle range, finite size of the sensor, and departure from cosine response on the uncertainty in the measurement of {rho}{sub se} The expanded relative uncertainty (95% confidence level) was found to be {+-}6% at the two visible wavelengths and {+-}8% at 856 nm. Both the magnitude and wavelength dependence of {rho}{sub se} for the present experiments are significantly different from those reported by Krishnan et al. for overfire soot produced using a turbulent flame. The results are compared with the predictions of fractal optics.

  4. Analysis of PCR Thermocycling by Rayleigh-Bénard Convection

    NASA Astrophysics Data System (ADS)

    Sharma, Ruchi; Ugaz, Victor

    2004-03-01

    In previous studies, we demonstrated a novel device employing the circulatory flow field established by Rayleigh-Bénard convection to perform amplification of a 295 base target region from a human genomic DNA template inside a 35 uL cylindrical cavity using the polymerase chain reaction (PCR) [Krishnan, Ugaz & Burns, Science, Vol. 298, 2002, p. 793]. This design eliminates the need for dynamic external temperature control required in conventional thermocyclers that repeatedly heat and cool static sample volumes to denaturation, annealing, and extension temperatures. In this paper, we extend these studies by demonstrating the design and operation of a multiwell convective flow device capable of achieving amplification of a 191 base pair fragment associated with membrane channel proteins M1 and M2 of the influenza-A virus in as little as 15 minutes with performance comparable to a conventional thermocycler. We also study the effect of initial template concentration and observe no degradation in performance over four orders of magnitude of initial template loading dilution, consistent with conventional thermocycler results. These results illustrate the ability of convective flow PCR systems to achieve performance equal to or exceeding conventional thermocycling hardware, and demonstrate their suitability for use in rapid biodetection assays.

  5. Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency

    PubMed Central

    Sroubek, Jakub; Krishnan, Yamini; McDonald, Thomas V.

    2013-01-01

    Human ether-á-gogo-related gene (HERG) encodes a potassium channel that is highly susceptible to deleterious mutations resulting in susceptibility to fatal cardiac arrhythmias. Most mutations adversely affect HERG channel assembly and trafficking. Why the channel is so vulnerable to missense mutations is not well understood. Since nothing is known of how mRNA structural elements factor in channel processing, we synthesized a codon-modified HERG cDNA (HERG-CM) where the codons were synonymously changed to reduce GC content, secondary structure, and rare codon usage. HERG-CM produced typical IKr-like currents; however, channel synthesis and processing were markedly different. Translation efficiency was reduced for HERG-CM, as determined by heterologous expression, in vitro translation, and polysomal profiling. Trafficking efficiency to the cell surface was greatly enhanced, as assayed by immunofluorescence, subcellular fractionation, and surface labeling. Chimeras of HERG-NT/CM indicated that trafficking efficiency was largely dependent on 5′ sequences, while translation efficiency involved multiple areas. These results suggest that HERG translation and trafficking rates are independently governed by noncoding information in various regions of the mRNA molecule. Noncoding information embedded within the mRNA may play a role in the pathogenesis of hereditary arrhythmia syndromes and could provide an avenue for targeted therapeutics.—Sroubek, J., Krishnan, Y., McDonald, T V. Sequence- and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency. PMID:23608144

  6. On Resolutions of Cosmological Singularities in Higher-Spin Gravity

    NASA Astrophysics Data System (ADS)

    Burrington, Benjamin; Pando Zayas, Leopoldo; Rombes, Nicholas

    2014-03-01

    Gravity in three dimensions is simpler than in four, due to the lack of gravitational waves, and can be recast as a Chern-Simons theory. In this context, it is straightforward to generalize Einstein's gravity, with or without cosmological constant, by changing the gauge group. Using this, we study the resolution of certain cosmological singularities, and extend the singularity resolution scheme proposed by Krishnan and Roy. We discuss the resolution of a big-bang singularity in the case of gravity coupled to a spin-4 field realized as Chern-Simons theory with gauge group SL (4 , C) . We show the existence of gauge transformations that do not change the holonomy of the Chern-Simons gauge potential and lead to metrics without the initial singularity. We argue that such transformations always exist in the context of gravity coupled to a spin-N field when described by Chern-Simons with gauge group SL (N , C) . This work was supported by the DOE under grant DE-FG02-95ER40899, a research grant from Troy University, and the Honors Summer Fellowship at the University of Michigan.

  7. Life assessment and emissions monitoring of Indian coal-fired power plants

    SciTech Connect

    Not Available

    1992-07-01

    At the request of the Pittsburgh Energy Technology Center (PETC) of the United States Department of Energy (USDOE), the traveler, along with Dr. R. P. Krishnan, Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee spent three weeks in India planning and performing emissions monitoring at the coal-fired Vijayawada Thermal Power Station (VTPS). The coordination for the Indian participants was provided by BHEL, Trichy and CPRI, Bangalore. The trip was sponsored by the PETC under the United States Agency for International Development (USAID)/Government of India (GOI)P Alternate Energy Resources Development (AERD) Project. The AERD Project is managed by PETC, and ORNL is providing the technical coordination and support for four coal projects that are being implemented with BHEL, Trichy. The traveler, after briefing the USAID mission in New Delhi visited BHEL, Trichy and CPRI, Bangalore to coordinate and plan the emissions test program. The site selection was made by BHEL, CPRI, TVA, and PETC. Monitoring was performed for 4 days on one of the 4 existing 210 MW coal-fired boilers at the VTPS, 400 km north of Madras, India.

  8. Life assessment and emissions monitoring of Indian coal-fired power plants. Final report

    SciTech Connect

    Not Available

    1992-07-01

    At the request of the Pittsburgh Energy Technology Center (PETC) of the United States Department of Energy (USDOE), the traveler, along with Dr. R. P. Krishnan, Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee spent three weeks in India planning and performing emissions monitoring at the coal-fired Vijayawada Thermal Power Station (VTPS). The coordination for the Indian participants was provided by BHEL, Trichy and CPRI, Bangalore. The trip was sponsored by the PETC under the United States Agency for International Development (USAID)/Government of India (GOI)P Alternate Energy Resources Development (AERD) Project. The AERD Project is managed by PETC, and ORNL is providing the technical coordination and support for four coal projects that are being implemented with BHEL, Trichy. The traveler, after briefing the USAID mission in New Delhi visited BHEL, Trichy and CPRI, Bangalore to coordinate and plan the emissions test program. The site selection was made by BHEL, CPRI, TVA, and PETC. Monitoring was performed for 4 days on one of the 4 existing 210 MW coal-fired boilers at the VTPS, 400 km north of Madras, India.

  9. Prediction of blood:air and fat:air partition coefficients of volatile organic compounds for the interpretation of data in breath gas analysis6

    PubMed Central

    Kramer, Christian; Mochalski, Paweł; Unterkofler, Karl; Agapiou, Agapios; Ruzsanyi, Veronika; Liedl, Klaus R

    2016-01-01

    In this article, a database of blood:air and fat:air partition coefficients (λb:a and λf:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a novel method for Henry’s law constants prediction developed. A random forest model based on Molecular Operating Environment 2D (MOE2D) descriptors based on 2619 literature-reported Henry’s constant values was built. The calculated Henry’s law constants correlate very well (R2test = 0.967) with the available experimental data. Blood:air and fat:air partition coefficients were calculated according to the method proposed by Poulin and Krishnan using the estimated Henry’s constant values. The obtained values correlate reasonably well with the experimentally determined ones for a test set of 90 VOCs (R2 = 0.95). The provided data aim to fill in the literature data gap and further assist the interpretation of results in studies of the human volatilome. PMID:26815030

  10. An anisotropic-fluid model for inhomogeneous Stokesian suspensions

    NASA Astrophysics Data System (ADS)

    Goddard, Joe

    2007-11-01

    A constitutive model is proposed for a suspension of rigid spheres with spatially non-uniform strain rate E and particle concentration φ. As in [1], the model involves a 4^th rank viscosity tensor depending on φ and a 2^nd rank structure tensor A determined by a kinematic evolution equations. The particle flux j is a linear function of the spatial gradients in φ, E, & A . In contrast to existing models [2,3], the constitutive equations exhibits Stokesian linearity in E, and all nonlinear suspension-dynamics effects are represented by A and its evolution. An expansion up to third order in A is given, and illustrative calculations are made for oscillatory simple shear based on parameters determined as in [1]. Desirably, the model offers a frame-indifferent description of the effects of streamline curvature on particle flux; and it admits transiently negative particle diffusivities following shear reversal, indicating dominance of Stokesian reversibility over shear-induced memory loss. The main drawback, is the plethora of scalar parameters, and possible simplifications inspired by previous models are discussed briefly. [1] J. D. Goddard, J. Fluid. Mech., 568:1--17, 2006. [2] G. P. Krishnan, et al., J. Fluid Mech., 321:371--93, 1996. [3] R. J. Phillips, et al., Phys. Fluids A, 4(1): 30--40, 1992.

  11. The second Mars microprobe is unloaded

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In the Spacecraft Assembly and Encapsulation Facility -2 (SAEF- 2), Chris Voorhees (left) and Satish Krishnan (right), from the Jet Propulsion Laboratory, remove the second Mars microprobe from a drum. Two microprobes will hitchhike on the Mars Polar Lander, scheduled to be launched Jan. 3, 1999, aboard a Delta II rocket. The solar-powered spacecraft is designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. The Mars microprobes, called Deep Space 2, are part of NASA's New Millennium Program. They will complement the climate-related scientific focus of the lander by demonstrating an advanced, rugged microlaser system for detecting subsurface water. Such data on polar subsurface water, in the form of ice, should help put limits on scientific projections for the global abundance of water on Mars.

  12. The first Mars microprobe is unloaded

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In the Spacecraft Assembly and Encapsulation Facility -2 (SAEF- 2), workers from the Jet Propulsion Laboratory open the drums containing the Mars microprobes that will hitchhike on the Mars Polar Lander. From left, they are Satish Krishnan, Charles Cruzan, Chris Voorhees and Arden Acord. Scheduled to be launched Jan. 3, 1999, aboard a Delta II rocket, the solar-powered spacecraft is designed to touch down on the Martian surface near the northern-most boundary of the south pole in order to study the water cycle there. The lander also will help scientists learn more about climate change and current resources on Mars, studying such things as frost, dust, water vapor and condensates in the Martian atmosphere. The Mars microprobes, called Deep Space 2, are part of NASA's New Millennium Program. They will complement the climate-related scientific focus of the lander by demonstrating an advanced, rugged microlaser system for detecting subsurface water. Such data on polar subsurface water, in the form of ice, should help put limits on scientific projections for the global abundance of water on Mars.

  13. Two body and multibody interaction in a cold Rydberg gas

    NASA Astrophysics Data System (ADS)

    Han, Jianing; Gallagher, Tom

    2009-05-01

    Cold Rydberg atoms trapped in a Magneto Optical Trap (MOT) are not isolated and they tend to bond through dipole-dipole and multiple-multiple interactions between Rydberg atoms. The dipole-dipole interaction and van der Waals interaction between two atoms have been intensively studied. However, the fact that the dipole-dipole interaction and van der Waals interaction show the same size of broadening, studied by Raithel's group, and there is transition between two molecular states, studied by Farooqi and Overstreet, can not be explained by the two atom picture. The purpose of this paper is to show the multibody nature of a dense cold Rydberg gas by studying the molecular state microwave spectrum. Specifically, single body, two body and three body interaction regions are separated. Moreover, the multibody energy levels for selected geometries are calculated. In addition, multibody blockade will be discussed. [3pt] [1] A. Reinhard, K. C. Younge, T. Cubel Liebisch, B. Knuffman, P. R. Berman, and G. Raithel, Phys. Rev. Lett. 100, 233201 (2008).[0pt] [2] S.M. Farooqi, D. Tong, S. Krishnan, J. Stanojevic,Y.P. Zhang, J.R. Ensher, A.S. Estrin, C. Boisseau, R. Cote, E.E. Eyler, and P.L. Gould, Phys. Rev. Lett. 91, 183002 (2003).[0pt] [3] K. Richard Overstreet, Arne Schwettmann, Jonathan Tallant, and James P. Shaffer, Phys. Rev. A 76, 011403 (2007).

  14. Disposal of Energy by UV-B Sunscreens

    NASA Astrophysics Data System (ADS)

    Nordlund, Thomas; Krishnan, Rajagopal

    2008-03-01

    Ideal sunscreens absorb dangerous UV light and dispose of the energy safely. ``Safe disposal'' usually means conversion to heat. However, efficient absorption entails a high radiative rate, which implies high energy-transfer and other rates, unless some process intervenes to ``defuse'' the excited state. We studied the excited-state kinetics of three UV-B (290-320 nm) sunscreens by absorption, steady-state and time-resolved fluorescence. Excited-state rate analysis suggests that some sunscreens have low radiative-rate ``dark'' states, in addition to normal excited states.* We deduce dark states when sunscreens of high extinction coefficient do not show lifetimes and total emission consistent with such high radiative rates. A high radiative rate, accompanied by efficient fluorescence emission and/or transfer, may be unfavorable for a sunscreen. In spite of its dark excited state, padimate O shows significant re-emission of light in the UV-A (320-400 nm) and energy transfer to a natural component of excised skin, probably collagen. * Krishnan, R. and T.M. Nordlund (2007) J. Fluoresc. DOI 10.1007/s10895-007-0264-3.

  15. A Polarized Light Microscopic Study to Comparatively evaluate Four Remineralizing Agents on Enamel viz CPP-ACPF, ReminPro, SHY-NM and Colgate Strong Teeth

    PubMed Central

    Krishnan, Ramesh; Bhaskaran, Bibin; Kumar, Suresh V

    2015-01-01

    ABSTRACT Aim: To compare and evaluate the remineralizing potential of four commercially available products namely SHY-NM, GC Tooth Mousse Plus, ReminPro and Colgate strong teeth on demineralized human teeth. Materials and methods: The study included 50 extracted premolars having 3 × 3 mm window prepared on the middle third of the tooth, which was then subjected to demineralization for 48 hours at 37°C. Teeth were randomly selected and grouped into five study groups of 10 teeth in each. Each group was treated with respective remineralizing agent and sectioned using hard-tissue microtome. Each section obtained was visualized under polarized light microscope and analyzed using Image J software. Results: The statistically evaluated results revealed that SHY-NM has the most remineralizing potential followed by ReminPro, GC Tooth Mousse Plus and fluoridated toothpaste. Conclusion: Based on the study, the SHY-NM was superior to the GC Tooth Mousse Plus, ReminPro and Colgate strong teeth on demineralized human teeth. How to cite this article: Rajan R, Krishnan R, Bhaskaran B, Kumar SV. A Polarized Light Microscopic Study to Comparatively evaluate Four Remineralizing Agents on Enamel viz CPP-ACPF, ReminPro, SHY-NM and Colgate Strong Teeth. Int J Clin Pediatr Dent 2015;8(1):42-47. PMID:26124580

  16. Characterization of Sleep in Aplysia californica

    PubMed Central

    Vorster, Albrecht P.A.; Krishnan, Harini C.; Cirelli, Chiara; Lyons, Lisa C.

    2014-01-01

    Study Objective: To characterize sleep in the marine mollusk, Aplysia californica. Design: Animal behavior and activity were assessed using video recordings to measure activity, resting posture, resting place preference, and behavior after rest deprivation. Latencies for behavioral responses were measured for appetitive and aversive stimuli for animals in the wake and rest states. Setting: Circadian research laboratory for Aplysia. Patients or Participants: A. californica from the Pacific Ocean. Interventions: N/A. Measurements and Results: Aplysia rest almost exclusively during the night in a semi-contracted body position with preferential resting locations in the upper corners of their tank. Resting animals demonstrate longer latencies in head orientation and biting in response to a seaweed stimulus and less frequent escape response steps following an aversive salt stimulus applied to the tail compared to awake animals at the same time point. Aplysia exhibit rebound rest the day following rest deprivation during the night, but not after similar handling stimulation during the day. Conclusions: Resting behavior in Aplysia fulfills all invertebrate characteristics of sleep including: (1) a specific sleep body posture, (2) preferred resting location, (3) reversible behavioral quiescence, (4) elevated arousal thresholds for sensory stimuli during sleep, and (5) compensatory sleep rebound after sleep deprivation. Citation: Vorster AP, Krishnan HC, Cirelli C, Lyons LC. Characterization of sleep in Aplysia californica. SLEEP 2014;37(9):1453-1463. PMID:25142567

  17. Dreaming of Atmospheres

    NASA Astrophysics Data System (ADS)

    Waldmann, Ingo

    2016-10-01

    Radiative transfer retrievals have become the standard in modelling of exoplanetary transmission and emission spectra. Analysing currently available observations of exoplanetary atmospheres often invoke large and correlated parameter spaces that can be difficult to map or constrain.To address these issues, we have developed the Tau-REx (tau-retrieval of exoplanets) retrieval and the RobERt spectral recognition algorithms. Tau-REx is a bayesian atmospheric retrieval framework using Nested Sampling and cluster computing to fully map these large correlated parameter spaces. Nonetheless, data volumes can become prohibitively large and we must often select a subset of potential molecular/atomic absorbers in an atmosphere.In the era of open-source, automated and self-sufficient retrieval algorithms, such manual input should be avoided. User dependent input could, in worst case scenarios, lead to incomplete models and biases in the retrieval. The RobERt algorithm is build to address these issues. RobERt is a deep belief neural (DBN) networks trained to accurately recognise molecular signatures for a wide range of planets, atmospheric thermal profiles and compositions. Using these deep neural networks, we work towards retrieval algorithms that themselves understand the nature of the observed spectra, are able to learn from current and past data and make sensible qualitative preselections of atmospheric opacities to be used for the quantitative stage of the retrieval process.In this talk I will discuss how neural networks and Bayesian Nested Sampling can be used to solve highly degenerate spectral retrieval problems and what 'dreaming' neural networks can tell us about atmospheric characteristics.

  18. Distribution of Fos-Like Immunoreactivity, Catecholaminergic and Serotoninergic Neurons Activated by the Laryngeal Chemoreflex in the Medulla Oblongata of Rats.

    PubMed

    Wang, Xiaolu; Guo, Ruichen; Zhao, Wenjing

    2015-01-01

    The laryngeal chemoreflex (LCR) induces apnea, glottis closure, bradycardia and hypertension in young and maturing mammals. We examined the distribution of medullary nuclei that are activated by the LCR and used immunofluorescent detection of Fos protein as a cellular marker for neuronal activation to establish that the medullary catecholaminergic and serotoninergic neurons participate in the modulation of the LCR. The LCR was elicited by the infusion of KCl-HCl solution into the laryngeal lumen of adult rats in the experimental group, whereas the control group received the same surgery but no infusion. In comparison, the number of regions of Fos-like immunoreactivity (FLI) that were activated by the LCR significantly increased in the nucleus of the solitary tract (NTS), the vestibular nuclear complex (VNC), the loose formation of the nucleus ambiguus (AmbL), the rostral ventral respiratory group (RVRG), the ventrolateral reticular complex (VLR), the pre-Bötzinger complex (PrBöt), the Bötzinger complex (Böt), the spinal trigeminal nucleus (SP5), and the raphe obscurus nucleus (ROb) bilaterally from the medulla oblongata. Furthermore, 12.71% of neurons with FLI in the dorsolateral part of the nucleus of the solitary tract (SolDL) showed tyrosine hydroxylase-immunoreactivity (TH-ir, catecholaminergic), and 70.87% of neurons with FLI in the ROb were serotoninergic. Our data demonstrated the distribution of medullary nuclei that were activated by the LCR, and further demonstrated that catecholaminergic neurons of the SolDL and serotoninergic neurons of the ROb were activated by the LCR, indicating the potential central pathway of the LCR. PMID:26087133

  19. Gloss, colour and grip: multifunctional epidermal cell shapes in bee- and bird-pollinated flowers.

    PubMed

    Papiorek, Sarah; Junker, Robert R; Lunau, Klaus

    2014-01-01

    Flowers bear the function of filters supporting the attraction of pollinators as well as the deterrence of floral antagonists. The effect of epidermal cell shape on the visual display and tactile properties of flowers has been evaluated only recently. In this study we quantitatively measured epidermal cell shape, gloss and spectral reflectance of flowers pollinated by either bees or birds testing three hypotheses: The first two hypotheses imply that bee-pollinated flowers might benefit from rough surfaces on visually-active parts produced by conical epidermal cells, as they may enhance the colour signal of flowers as well as the grip on flowers for bees. In contrast, bird-pollinated flowers might benefit from flat surfaces produced by flat epidermal cells, by avoiding frequent visitation from non-pollinating bees due to a reduced colour signal, as birds do not rely on specific colour parameters while foraging. Moreover, flat petal surfaces in bird-pollinated flowers may hamper grip for bees that do not touch anthers and stigmas while consuming nectar and thus, are considered as nectar thieves. Beside this, the third hypothesis implies that those flower parts which are vulnerable to nectar robbing of bee- as well as bird-pollinated flowers benefit from flat epidermal cells, hampering grip for nectar robbing bees. Our comparative data show in fact that conical epidermal cells are restricted to visually-active parts of bee-pollinated flowers, whereas robbing-sensitive parts of bee-pollinated as well as the entire floral surface of bird-pollinated flowers possess on average flat epidermal cells. However, direct correlations between epidermal cell shape and colour parameters have not been found. Our results together with published experimental studies show that epidermal cell shape as a largely neglected flower trait might act as an important feature in pollinator attraction and avoidance of antagonists, and thus may contribute to the partitioning of flower-visitors.

  20. Nectar robbery by a hermit hummingbird: association to floral phenotype and its influence on flowers and network structure.

    PubMed

    Maruyama, Pietro Kiyoshi; Vizentin-Bugoni, Jeferson; Dalsgaard, Bo; Sazima, Ivan; Sazima, Marlies

    2015-07-01

    Interactions between flowers and their visitors span the spectrum from mutualism to antagonism. The literature is rich in studies focusing on mutualism, but nectar robbery has mostly been investigated using phytocentric approaches focused on only a few plant species. To fill this gap, we studied the interactions between a nectar-robbing hermit hummingbird, Phaethornis ruber, and the array of flowers it visits. First, based on a literature review of the interactions involving P. ruber, we characterized the association of floral larceny to floral phenotype. We then experimentally examined the effects of nectar robbing on nectar standing crop and number of visits of the pollinators to the flowers of Canna paniculata. Finally, we asked whether the incorporation of illegitimate interactions into the analysis affects plant-hummingbird network structure. We identified 97 plant species visited by P. ruber and found that P. ruber engaged in floral larceny in almost 30% of these species. Nectar robbery was especially common in flowers with longer corolla. In terms of the effect on C. paniculata, the depletion of nectar due to robbery by P. ruber was associated with decreased visitation rates of legitimate pollinators. At the community level, the inclusion of the illegitimate visits of P. ruber resulted in modifications of how modules within the network were organized, notably giving rise to a new module consisting of P. ruber and mostly robbed flowers. However, although illegitimate visits constituted approximately 9% of all interactions in the network, changes in nestedness, modularity, and network-level specialization were minor. Our results indicate that although a flower robber may have a strong effect on the pollination of a particular plant species, the inclusion of its illegitimate interactions has limited capacity to change overall network structure.

  1. Molecular studies of free and translocation trisomy

    SciTech Connect

    Robinson, W.P.; Bernasconi, F.; Lefort, G.

    1994-09-01

    Twenty cases of trisomy 13 were examined with molecular markers to determine the origin of the extra chromosome. Six cases had translocation trisomy: two de novo rob(13q;14q), one paternally derived rob(13q;14q), two de novo t(13q;13q), and one mosaic de novo t(13q;14q), one paternally derived rob(13q;14q), two de novo t(13q;13q), and one mosaic de novo t(13q;13q)r(13). Eighteen of nineteen informative patients were consistant with a maternal origin of the extra chromosome. Lack of a third allele at any locus in any of the three t(13q;13q) cases indicate that all were most likely isochromosomes of post-meiotic origin. In addition, two free trisomy cases were compatible with a somatic origin. Two mosaic free trisomy-13 cases, however, were both consistent with a maternal meiotic origin. The patient with a paternal inheritance of the translocation chromosome was purely coincidental. Since there is not a significantly increased risk for unbalanced offspring of a t(13;14) carrier and most trisomies are maternal in origin, this result should not be surprising; however it illustrates that one cannot infer the origin of translocation trisomy based on parental origin of the translocation. One balanced (non-trisomic) case with a non-mosaic 45,-13,-13,+t(13;13) karyotype was also investigated and was determined to be a somatic Robertsonian translocation between the maternal and paternal homologs, as has been found for all homologous Robertsonian translocations so far investigated. It is therefore also incorrect to assume in de novo translocation cases that the two involved chromosomes are even from the same parent. We cannot therefore infer anything about the origin of the chromosomes 13 and 14 involved in the two cases with de novo t(13q;14q) plus a maternally derived trisomy 13.

  2. Activation of 5‐HT2A receptors by TCB‐2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro

    PubMed Central

    Spindle, Michael S.; Thomas, Mark P.

    2014-01-01

    Abstract The medial prefrontal cortex (mPFC) is a region of neocortex that plays an integral role in several cognitive processes which are abnormal in schizophrenic patients. As with other cortical regions, large‐bodied layer 5 pyramidal neurons serve as the principle subcortical output of microcircuits of the mPFC. The coexpression of both inhibitory serotonin 5‐HT1A receptors on the axon initial segments, and excitatory 5‐HT2A receptors throughout the somatodendritic compartments, by layer 5 pyramidal neurons allows serotonin to provide potent top–down regulation of input–output relationships within cortical microcircuits. Application of 5‐HT2A agonists has previously been shown to enhance synaptic input to layer 5 pyramidal neurons, as well as increase the gain in neuronal firing rate in response to increasing depolarizing current steps. Using whole‐cell patch‐clamp recordings obtained from layer 5 pyramidal neurons of the mPFC of C57/bl6 mice, the aim of our present study was to investigate the modulation of long‐term spike trains by the selective 5‐HT2A agonist TCB‐2. We found that in the presence of synaptic blockers, TCB‐2 induced recurrent oscillatory bursting (ROB) after 15–20 sec of tonic spiking in 7 of the 14 cells. In those seven cells, ROB discharge was accurately predicted by the presence of a voltage sag in response to a hyperpolarizing current injection. This effect was reversed by 5–10 min of drug washout and ROB discharge was inhibited by both synaptic activity and coapplication of the 5‐HT2A/2C antagonist ketanserin. While the full implications of this work are not yet understood, it may provide important insight into serotonergic modulation of cortical networks. PMID:24844635

  3. SSH-BM-I, a tryptamine derivative, stimulates mineralization in terminal osteoblast differentiation but inhibits osteogenesis of pre-committed progenitor cells.

    PubMed

    Mikami, Yoshikazu; Somei, Masanori; Tsuda, Hiromasa

    2011-01-01

    SSH-BM-I was synthesized from tryptamine by using a newly developed synthetic method, and it has structural similarity to bromomelatonin. Recently, it had been reported that SSH-BM-I increases osteoblasts in scales of gold fish. However, the effect of SSH-BM-I on osteoblast differentiation in mammalian cells has not yet been examined. Therefore, this study examined the effect of SSH-BM-I on osteoblast differentiation in mesenchymal progenitor-like cells and mature osteoblast-like cells. SSH-BM-I enhanced terminal osteoblast differentiation, as indicated by mineralization, which was accompanied by upregulation of the osteogenic marker genes bone sialoprotein (BSP) and osteocalcin (OC). However, in mesenchymal progenitor ROB-C26 cultures, no mineralized nodules were observed regardless of SSH-BM-I treatment, although BMP-2 was able to induce nodule formation in these cells. Furthermore, BMP-2-induced nodule formation was suppressed by SSH-BM-I treatment in ROB-C26 cultures. We further investigated the impact of the timing and duration of SSH-BM-I treatment on osteoblast differentiation. The effect of SSH-BM-I treatment on osteoblast differentiation of ROB-C26 in the presence of BMP-2 switches from negative to positive sometime between day 6 and 9, because SSH-BM-I treatment enhanced the formation of mineralized nodules when it was started on day 9, but suppressed nodule formation when it was started at day 6 or earlier. These results suggest that the stimulatory effects of SSH-BM-I on the formation of mineralized nodules depend on the degree of cell differentiation.

  4. Cross-sectional study of sociodemographic patterning of risk factors for cardiovascular disease in three isolated-based subgroups of the Uyghur population in Xinjiang, China

    PubMed Central

    Jiang, Jingmei; Wufuer, Mayila; Simayi, Amuti; Nijiati, Muyesai; Fan, Ming; Zhu, Pengcheng; Chen, Fenghui; Shan, Guangliang; Xue, Fang; Tian, Xiaobing; Li, Feng; Hou, Lei; Han, Wei; Cheng, Zuheng; Qiu, Changchun

    2013-01-01

    Objective To explore the sociodemographic patterning of risk factors for cardiovascular disease (CVD) in three isolated-based subgroups of the Uyghur population in Xinjiang, China. Design A cross-sectional study. Between 2005 and 2008, a non-probability sampling design method was used to select three specific groups of the Uyghur rural populations based on their potential socioeconomic status (ie, isolated, semi-isolated and open-environment status). Setting Three communities (named Desert, Turpan and Yuli Rob) in Southern Xinjiang autonomous region, China. Participants 1656 people were included in this study. The inclusion criteria were that all participants were 18 years or older, they were descendants of at least three generations living in the same region, and there was no history of intermarriage. Main outcome measures The prevalence of CVD risk factors (ie, tobacco use, alcohol use, obesity, dyslipidemia, hypertension, diabetes, etc) was assessed. Results Compared with the Desert and Turpan communities, Yuli Rob had the highest levels of obesity, dyslipidemia and hypertension, and the Desert had the lowest levels of CVD risk factors. Age standardisation slightly altered the estimates, though the patterns remained unchanged. Some unique characteristics were also found. For example, the Desert group displayed significantly lower high-density lipoprotein cholesterol (HDLC) level compared with Yuli Rob and Turpan groups. The mean values were 0.63, 1.06 and 1.45 mmol/l for men and 0.64, 1.22 and 1.51 mmol/l for women (p<0.0001). The HDLC levels in the Desert group increased with increase in body mass index and fasting glucose levels, which was inconsistent with previous studies. Conclusions Identifying the unique CVD risk factors of the ethnic-specific populations is very important in development of tailored strategies for the prevention of CVD. PMID:23503578

  5. Nectar robbery by a hermit hummingbird: association to floral phenotype and its influence on flowers and network structure.

    PubMed

    Maruyama, Pietro Kiyoshi; Vizentin-Bugoni, Jeferson; Dalsgaard, Bo; Sazima, Ivan; Sazima, Marlies

    2015-07-01

    Interactions between flowers and their visitors span the spectrum from mutualism to antagonism. The literature is rich in studies focusing on mutualism, but nectar robbery has mostly been investigated using phytocentric approaches focused on only a few plant species. To fill this gap, we studied the interactions between a nectar-robbing hermit hummingbird, Phaethornis ruber, and the array of flowers it visits. First, based on a literature review of the interactions involving P. ruber, we characterized the association of floral larceny to floral phenotype. We then experimentally examined the effects of nectar robbing on nectar standing crop and number of visits of the pollinators to the flowers of Canna paniculata. Finally, we asked whether the incorporation of illegitimate interactions into the analysis affects plant-hummingbird network structure. We identified 97 plant species visited by P. ruber and found that P. ruber engaged in floral larceny in almost 30% of these species. Nectar robbery was especially common in flowers with longer corolla. In terms of the effect on C. paniculata, the depletion of nectar due to robbery by P. ruber was associated with decreased visitation rates of legitimate pollinators. At the community level, the inclusion of the illegitimate visits of P. ruber resulted in modifications of how modules within the network were organized, notably giving rise to a new module consisting of P. ruber and mostly robbed flowers. However, although illegitimate visits constituted approximately 9% of all interactions in the network, changes in nestedness, modularity, and network-level specialization were minor. Our results indicate that although a flower robber may have a strong effect on the pollination of a particular plant species, the inclusion of its illegitimate interactions has limited capacity to change overall network structure. PMID:25740333

  6. Scope processing in Chinese.

    PubMed

    Zhou, Peng; Gao, Liqun

    2009-02-01

    The standard view maintains that quantifier scope interpretation results from an interaction between different modules: the syntax, the semantics as well as the pragmatics. Thus, by examining the mechanism of quantifier scope interpretation, we will certainly gain some insight into how these different modules interact with one another. To observe it, two experiments, an offline judgment task and an eye-tracking experiment, were conducted to investigate the interpretation of doubly quantified sentences in Chinese, like Mei-ge qiangdao dou qiang-le yi-ge yinhang (Every robber robbed a bank). According to current literature, doubly quantified sentences in Chinese like the above are unambiguous, which can only be interpreted as "for every robber x, there is a bank y, such that x robbed y"(surface scope reading), contrary to their ambiguous English counterparts, which also allow the interpretation that "there is a bank y, such that for every robber x, x robbed y"(inverse scope reading). Specifically, three questions were examined, that is, (i) What is the initial reading of doubly quantified sentences in Chinese? (ii) Whether inverse scope interpretation can be available if appropriate contexts are provided? (iii) What are the processing time courses engaged in quantifier scope interpretation? The results showed that (i) Initially, the language processor computes the surface scope representation and the inverse scope representation in parallel, thus, doubly quantified sentences in Chinese are ambiguous; (ii) The discourse information is not employed in initial processing of relative scope, it serves to evaluate the two representations in reanalysis; (iii) The lexical information of verbs affects their scope-taking patterns. We suggest that these findings provide evidence for the Modular Model, one of the major contenders in the literature on sentence processing.

  7. Mapping the differential reddening in globular clusters

    NASA Astrophysics Data System (ADS)

    Bonatto, C.; Campos, Fabíola; Kepler, S. O.

    2013-10-01

    We build differential-reddening maps for 66 Galactic globular clusters (GCs) with archival Hubble Space Telescope WFC/ACS F606W and F814W photometry. Because of the different GC sizes (characterized by the half-light radius Rh) and distances to the Sun, the WFC/ACS field of view (200 arcsec × 200 arcsec) coverage (Robs) lies in the range 1 ≲ Robs/Rh ≲ 15 for about 85 per cent of the sample, with about 10 per cent covering only the inner (Robs ≲ Rh) parts. We divide the WFC/ACS field of view across each cluster in a regular cell grid and extract the stellar-density Hess diagram from each cell, shifting it in colour and magnitude along the reddening vector until matching the mean diagram. Thus, the maps correspond to the internal dispersion of the reddening around the mean. Depending on the number of available stars (i.e. probable members with adequate photometric errors), the angular resolution of the maps range from ≈ 7 arcsec × 7 arcsec to ≈ 20 arcsec × 20 arcsec. We detect spatially variable extinction in the 66 GCs studied, with mean values ranging from < δE(B-V)> ≡ 0.018 (NGC 6981) up to <δE(B-V)> ≡ 0.016 (Palomar 2). Differential-reddening correction decreases the observed foreground reddening and the apparent distance modulus but, since they are related to the same value of E(B - V), the distance to the Sun is conserved. Fits to the mean-ridge lines of the highly extincted and photometrically scattered GC Palomar 2 show that age and metallicity also remain unchanged after the differential-reddening correction, but measurement uncertainties decrease because of the reduced scatter. The lack of systematic variations of <δE(B-V)> with both the foreground reddening and the sampled cluster area indicates that the main source of differential reddening is interstellar.

  8. Retinoids for Treatment of Retinal Diseases

    PubMed Central

    Palczewski, Krzysztof

    2010-01-01

    Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has expanded exponentially over the past decade. Substantial progress in human genetics has allowed identification of candidate genes and complex networks underlying inherited retinal diseases. Natural mutations in animal models that mimic human diseases have been characterized and advanced genetic manipulation now permits generation of small mammalian models of human retinal diseases. Pharmacological repair of defective visual processes in animal models not only validates their involvement in vision but also provides great promise for developing improved therapies for the millions that are progressing towards blindness or are almost completely robbed of eyesight. PMID:20435355

  9. Building better therapy for children with acute lymphoblastic leukemia.

    PubMed

    Carroll, William L; Raetz, Elizabeth A

    2005-04-01

    Childhood acute lymphoblastic leukemia is one of the most curable of all human cancers, but new approaches are urgently needed for children who relapse and to avoid severe side effects of curative therapy. Work from the laboratories of Rob Pieters and William Evans, including a paper in this issue of Cancer Cell, has led to the identification of genes whose expression correlates with drug crossresistance and long term outcome. The goal is now to integrate these and other findings using gene expression technology into the care of children with the most common pediatric malignancy. PMID:15837616

  10. Structural approaches to understanding retinal proteins needed for vision.

    PubMed

    Orban, Tivadar; Jastrzebska, Beata; Palczewski, Krzysztof

    2014-04-01

    The past decade has witnessed an impressive expansion of our knowledge of retinal photoreceptor signal transduction and the regulation of the visual cycle required for normal eyesight. Progress in human genetics and next generation sequencing technologies have revealed the complexity behind many inherited retinal diseases. Structural studies have markedly increased our understanding of the visual process. Moreover, technical innovations and improved methodologies in proteomics, macromolecular crystallization and high resolution imaging at different levels set the scene for even greater advances. Pharmacology combined with structural biology of membrane proteins holds great promise for developing innovative accessible therapies for millions robbed of their sight or progressing toward blindness.

  11. COMMITTEES: SQM2006 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Organising Committee Kenneth Barish Huan Zhong Huang Joseph Kapusta Grazyna Odyniec Johann Rafelski Charles A Whitten Jr International Advisory Committee Jörg Aichelin Federico Antinori Tamas Biró Jean Cleymans Lazlo Csernai Tim Hallman Ulrich Heinz Sonja Kabana Rob Lacey Yu-Gang Ma Jes Madsen Yasuo Miake Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Johann Rafelski Hans Ritter Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Wen-Qing Shen Georges Stephans Horst Stöcker Thomas Ullrich Bill Zajc

  12. Histamine H₃ receptors modulate depolarization-evoked [³H]-noradrenaline release from rat olfactory bulb slices.

    PubMed

    Aquino-Miranda, Guillermo; Osorio-Espinoza, Angélica; Escamilla-Sánchez, Juan; González-Pantoja, Raúl; Ortiz, Jordi; Arias-Montaño, José-Antonio

    2012-02-01

    We have studied the effect of histamine H(3) receptor (H(3)R) activation on the depolarization-evoked release of labeled neurotransmitters from slices of the rat olfactory bulb (rOB). The presence of pre-synaptic H(3)Rs was evidenced by the specific binding of the H(3)R ligand N-α-[methyl-(3)H]histamine to membranes from rOB synaptosomes (maximum binding, B(max), 106 ± 19 fmol/mg protein; dissociation constant, K(d), 0.68 ± 0.11 nM) which was inhibited by selective H(3)R ligands (immepip, (R)(-)-α-methylhistamine (RAMH) and clobenpropit) with affinities similar to those previously reported for H(3)Rs expressed in other rat brain areas. Perfusion of rOB slices with the selective H(3)R agonist RAMH (0.1 and 1 μM) had no effect on the release of [(3)H]-γ-aminobutyric acid ([(3)H]-GABA), [(3)H]-d-aspartate, [(3)H]-dopamine or [(3)H]-5-hydroxytryptamine ([(3)H]-5-HT) evoked by depolarization with high K(+) (20 or 40 mM). [(3)H]-Noradrenaline release induced by 20 mM K(+) was reduced in a modest but significant manner by RAMH (94.9 ± 1.7% and 83.1 ± 2.1% of control release at 0.1 and 1 μM, respectively). The effect of 1 μM RAMH was blocked by the selective H(3)R antagonist/inverse agonist clobenpropit (5 μM). When tested alone clobenpropit and a second H(3)R antagonist/inverse agonist, ciproxifan (both at 1 μM) significantly increased K(+)-evoked [(3)H]-noradrenaline release to 119.4 ± 4.2% and 120.0 ± 3.7% of K(+) alone, respectively. Ciproxifan (1 μM) had no effect on the depolarization-evoked release of the other labeled neurotransmitters. These data indicate that H(3)Rs with constitutive activity modulate noradrenaline release in rOB, presumably through a pre-synaptic action. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

  13. DIRECTOR/PRODUCER ROBERT ZEMECKIS DURING FILMING OF 'CONTACT' AT LC39 PRESS SITE

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Robert Zemeckis, director/producer, and other Warner Bros. crew members oversee the filming of scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

  14. Musical tradition, insurrection, and resurrection: the life and legacy of composer/bassist Charles Mingus.

    PubMed

    St Louis, E K

    1999-01-01

    Charles Mingus was perhaps the foremost straight-ahead jazz upright bassist and composer of his generation, blending the inspirational influences of gospel, jazz improvisation, and art music leanings into a unique style all his own. His demise from amyotrophic lateral sclerosis (ALS) in his fifth decade robbed the world of one of the great creative voices of American music. Aspects of Mingus' life, his career as a bassist, bandleader, and composer, and his neuromuscular illness are discussed, emphasizing his legacy for the disparate fields of jazz and neurology. PMID:10718524

  15. The development of e-MERLIN

    NASA Astrophysics Data System (ADS)

    Garrington, Simon; Beswick, Rob

    2016-06-01

    Deep in the heart of the Cheshire countryside lies Jodrell Bank Observatory, home to the UK's national facility for high-resolution radio astronomy: e-MERLIN, the enhanced Multi-Element Remote-Linked Interferometer Network. In this issue of A&G, the e-MERLIN team highlights some of its cutting-edge experiments, probing fundamental physical processes in our own galaxy, and reaching further out to higher redshift where radio astronomy can investigate cosmic history and evolution. In this first article, Simon Garrington and Rob Beswick explain how e-MERLIN came to be.

  16. Acidification of Europa's subsurface ocean as a consequence of oxidant delivery.

    PubMed

    Pasek, Matthew A; Greenberg, Richard

    2012-02-01

    Oxidants are formed at the surface of Europa and may be delivered to the subsurface ocean, possibly in great quantities. Whether these substances would be available for biological metabolism is uncertain, because they may react with sulfides and other compounds to generate sulfuric and other acids. If this process has been active on Europa for much of its age, then not only would it rob the ocean of life-supporting oxidants but the subsurface ocean could have a pH of ~2.6, which is so acidic as to present an environmental challenge for life, unless organisms consume or sequester the oxidants fast enough to ameliorate the acidification.

  17. VizieR Online Data Catalog: Astrometric observations of Phobos (Pasewaldt+, 2015)

    NASA Astrophysics Data System (ADS)

    Pasewaldt, A.; Oberst, J.; Willner, K.; Beisembin, B.; Hoffmann, H.; Matz, K. D.; Roatsch, T.; Michael, G.; Cardesin-Moinelo, A.; Zubarev, A. E.

    2015-04-01

    The data is given in the form of two tables. Each table contains the same set of observations: Data in tablea1.dat has been reduced using MEX navigation orbits and predicted attitude by the European Space Operations Centre (ESOC). tablea2.dat data has been derived using MEX accurate orbits by the Royal Observatory of Belgium (ROB) and measured attitude by the European Space Astronomy Centre (ESAC). >From 158 astrometric observations 103 were determined by means of both methods, 27 using only control point measurements, and 28 performing only limb fit observations. Hence, each data table contains 261 entries, namely 130 control point measurements and 131 limb fit observations. (2 data files).

  18. [Atopic eczema can be treated in a pre-emptive manner].

    PubMed

    Snellman, Erna

    2015-01-01

    The inflammation and itching associated with atopic eczema can rob the patient and even the whole family of their night's sleep. Cutaneous symptoms can be quickly alleviated with a glucocorticoid cream. Calcineurin inhibitors are an alternative to glucocorticoids. Regular washing of the skin must not be forgotten. In the treatment of moderate and severe atopic eczema, the frequency of applications of the medicinal cream is decreased only after the itching has ceased. Maintenance therapy does not seem to have more adverse effects than the conventional reactive mode of treatment, and can in fact be recommended especially for adults affected with moderate and severe atopic eczema. PMID:26245046

  19. Acquisition of Basic Behaviors through Teleoperation using Robonaut

    NASA Technical Reports Server (NTRS)

    Campbell, Christina

    2004-01-01

    My area of research is in artificial intelligence and robotics. The major platform of this research is NASA's Robonaut. This humanoid robot is located at the Johnson Space Center. Prior to receiving this grant, I was able to spend two summers in Houston working with the Robonaut team, which is headed by Rob Ambrose. My work centered on teaching Robonaut to grasp a wrench based on data gathered as a human teleoperated the robot. I tried to make the procedure as general as possible so that many different motions could be taught using this method.

  20. COMMITTEES: SQM2004 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2005-06-01

    Organising Committee Jean Cleymans (Chairman) Zeblon Vilakazi Roger Fearick Peter Steinberg Rory Adams Bruce Becker Sarah Blyth Gareth de Vaux Heather Gray Mark Horner Nawahl Razak Artur Szostak Spencer Wheaton International Advisory Committee Federico Antinori Tim Hallman John Harris Tetsuo Hatsuda Ulrich Heinz Huan Z Huang Sonja Kabana Volker Koch Rob Lacey Jes Madsen Yasuo Miake Maurizio Morando Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Josef Pochodzalla Johann Rafelski Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Georges Stephans Horst Stoecker Herbert Stroebele Thomas Ullrich Orlando Villalobos-Baillie Bill Zajc Joseph Zimanyi

  1. EDITORIAL: Special section on signal transduction Special section on signal transduction

    NASA Astrophysics Data System (ADS)

    Shvartsman, Stanislav

    2012-08-01

    , where a single molecule can participate in multiple types of interactions. Mathematical analysis of these models is discussed in the papers by Del Vecchio [8], Seaton and Krishnan [9], and Hatzimanikatis and colleagues [10]. Finally, all signaling systems are information processing devices. While this point is broadly accepted, there have been only a few attempts to apply information theory to experimental signaling systems. A review by Andre Levchenko and colleagues [11] provides a very clear introduction to information theory and its potential applications to signal transduction in cellular systems. References [1] Félix M-A 2012 Phys. Biol. 9 045001 [2] Oron E and Ivanova N 2012 Phys. Biol. 9 045002 [3] MacNamara A et al 2012 Phys. Biol. 9 045003 [4] Jensen K J and Janes K A 2012 Phys. Biol. 9 045004 [5] Zarnitsyna V and Zhu C 2012 Phys. Biol. 9 045005 [6] Rubinstein B et al 2012 Phys. Biol. 9 045006 [7] Frank T D et al 2012 Phys. Biol. 9 045007 [8] Del Vecchio D et al 2012 Phys. Biol. 9 045008 [9] Seaton D D and Krishnan J 2012 Phys. Biol. 9 045009 [10] Radivojevic A et al 2012 Phys. Biol. 9 045010 [11] Rhee A et al 2012 Phys. Biol. 9 045011

  2. Econo-Thermodynamics: The Nature of Economic Interactions

    NASA Astrophysics Data System (ADS)

    Mimkes, Juergen

    2006-03-01

    Physicists often model economic interactions like collisions of atoms in gases: by interaction one agent gains, the other loses. This leads to a Boltzmann distribution of capital, which has been observed in wealth distributions of different countries. However, economists object: no economic agent will attend a market in which he gets robbed! This conflict may be resolved by writing basic laws of economics into terms of calculus. In these terms the daily struggle for survival of all economic systems turns out to be a Carnot cycle that is driven by energy: heat pumps and economic production depend on oil, GNP and oil consumption run parallel for all countries. Motors and markets are based on the same laws of calculus (macro-economics) and statistics (micro-economics). Economic interactions mean exploiting a third party (nature) and are indeed close to robbing! A baker sells bread to his customers, but the flour comes from nature. Banks sells loans to investors, but the money comes from savers. Econo-thermodynamics is a thrilling new interdisciplinary field.

  3. A passionate love: the contributions of the late professor Robert John Barrett.

    PubMed

    Chur-Hansen, Anna

    2007-10-01

    Professor Robert John Barrett died suddenly, after a long and difficult illness, on January 12th, 2007. At the time of his death, at the age of 57, he was Head of the Discipline of Psychiatry at the Royal Adelaide Hospital, University of Adelaide. His passing was mourned by countless individuals in Australia and internationally. The celebration of his life, held in the University of Adelaide's Bonython Hall, from which generations of scholars have received their parchments upon graduation, was an emotive ritual of which Rob would have both approved and also enjoyed immensely. The Hall was filled to capacity, with over 1300 people listening to a collection of his favourite music and tributes delivered by eight of his friends and family members. Dignitaries in full academic regalia, including the Vice-Chancellor, the immediate past and current Deans of Medicine, and the Head of School oversaw proceedings from an elevated position in the Hall, the symbolic meaning of which would have caused Rob to smile wryly. A reflection of his life in pictures, at the conclusion of the ceremony, before the pall-bearers carried his coffin to the hearse, evoked yet more tears and grief at the tragic and untimely loss of this man: an outstanding intellectual, wise mentor, gifted teacher, caring doctor, and true and loyal friend.

  4. Middle-Ear Microsurgery Simulation to Improve New Robotic Procedures

    PubMed Central

    Kazmitcheff, Guillaume; Nguyen, Yann; Miroir, Mathieu; Péan, Fabien; Ferrary, Evelyne; Cotin, Stéphane; Sterkers, Olivier; Duriez, Christian

    2014-01-01

    Otological microsurgery is delicate and requires high dexterity in bad ergonomic conditions. To assist surgeons in these indications, a teleoperated system, called RobOtol, is developed. This robot enhances gesture accuracy and handiness and allows exploration of new procedures for middle ear surgery. To plan new procedures that exploit the capacities given by the robot, a surgical simulator is developed. The simulation reproduces with high fidelity the behavior of the anatomical structures and can also be used as a training tool for an easier control of the robot for surgeons. In the paper, we introduce the middle ear surgical simulation and then we perform virtually two challenging procedures with the robot. We show how interactive simulation can assist in analyzing the benefits of robotics in the case of complex manipulations or ergonomics studies and allow the development of innovative surgical procedures. New robot-based microsurgical procedures are investigated. The improvement offered by RobOtol is also evaluated and discussed. PMID:25157373

  5. Biological treatment in rheumatic diseases: results from a longitudinal surveillance: adverse events.

    PubMed

    Konttinen, L; Honkanen, V; Uotila, T; Pöllänen, J; Waahtera, M; Romu, M; Puolakka, K; Vasala, M; Karjalainen, A; Luukkainen, R; Nordström, D C

    2006-08-01

    The objective of this study was to assess the long-term safety and tolerability of biologicals in a clinical setting. Data on adverse events (AEs) have been collected over a 5-year period by means of detailed reports sent in to the National Register of Biological Treatment in Finland (ROB-FIN) and validated by information collected by the National Agency for Medicines. Three hundred and eight reports on AEs were filed, concerning a total of 248 patients; this corresponds to 17% of all patients in the ROB-FIN register who started biological treatments. Skin reactions and infections comprised 35 and 28% of the AEs, respectively. Some cases of tuberculosis and other infections, heart failure and demyelinating conditions were seen. Our work demonstrates no unexpected AEs in a Finnish patient cohort consisting of rheumatoid arthritis and spondylarthropathy patients, although many of them were treated with combination treatments in common use in Finland. Biological treatment appears safe in the hands of the Finnish rheumatologists.

  6. Membrane Stresses Induced by Overproduction of Free Fatty Acids in Escherichia coli.

    SciTech Connect

    Lennen, Rebecca M.; Kruziki, Max A.; Kumar, Kritika; Zinkel, Robert A.; Burnum, Kristin E.; Lipton, Mary S.; Hoover, Spencer W.; Ranatunga, Don Ruwan; Wittkopp, Tyler M.; Marner II, Wesley D.; Pfleger, Brian F.

    2011-11-01

    Microbially produced fatty acids are potential precursors to high energy density biofuels, including alkanes and alkyl ethyl esters by either catalytic conversion of free fatty acids (FFAs) or enzymatic conversions of acyl-acyl carrier protein or acyl-coenzyme A intermediates. Metabolic engineering efforts aimed at overproducing FFAs in Escherichia coli have achieved less than 30% of the maximum theoretical yield on the supplied carbon source. In this work, the viability, morphology, transcript levels, and protein levels of a strain of E. coli that overproduces medium chain length FFAs was compared to an engineered control strain. By early stationary phase, an 85% reduction in viable cell counts and exacerbated loss of inner membrane integrity were observed in the FFA overproducing strain. These effects were enhanced in strains endogenously producing FFAs compared to strains exposed to exogenously fed FFAs. Under two sets of cultivation conditions, long chain unsaturated fatty acid content greatly increased and the expression of genes and proteins required for unsaturated fatty acid biosynthesis were significantly decreased. Membrane stresses were further implicated by increased expression of genes and proteins of the phage shock response, the MarA/Rob/SoxS regulon, and the nuo and cyo operons of aerobic respiration. Gene deletion studies confirmed the importance of the phage shock proteins and Rob for maintaining cell viability, however little to no change in FFA titers was observed after 24 h cultivation. The results of this study serve as a baseline for future targeted attempts to improve FFA yields and titers in E. coli.

  7. The hunter becomes the hunted: when cleptobiotic insects are captured by their target ants.

    PubMed

    Dejean, Alain; Carpenter, James M; Corbara, Bruno; Wright, Pamela; Roux, Olivier; Lapierre, Louis M

    2012-04-01

    Here we show that trying to rob prey (cleptobiosis) from a highly specialized predatory ant species is risky. To capture prey, Allomerus decemarticulatus workers build gallery-shaped traps on the stems of their associated myrmecophyte, Hirtella physophora. We wondered whether the frequent presence of immobilized prey on the trap attracted flying cleptoparasites. Nine social wasp species nest in the H. physophora foliage; of the six species studied, only Angiopolybia pallens rob prey from Allomerus colonies. For those H. physophora not sheltering wasps, we noted cleptobiosis by stingless bees (Trigona), social wasps (A. pallens and five Agelaia species), assassin bugs (Reduviidae), and flies. A relationship between the size of the robbers and their rate of capture by ambushing Allomerus workers was established for social wasps; small wasps were easily captured, while the largest never were. Reduviids, which are slow to extract their rostrum from prey, were always captured, while Trigona and flies often escaped. The balance sheet for the ants was positive vis-à-vis the reduviids and four out of the six social wasp species. For the latter, wasps began by cutting up parts of the prey's abdomen and were captured (or abandoned the prey) before the entire abdomen was retrieved so that the total weight of the captured wasps exceeded that of the prey abdomens. For A. pallens, we show that the number of individuals captured during attempts at cleptobiosis increases with the size of the Allomerus' prey.

  8. Dreaming of Atmospheres

    NASA Astrophysics Data System (ADS)

    Waldmann, I. P.

    2016-04-01

    Here, we introduce the RobERt (Robotic Exoplanet Recognition) algorithm for the classification of exoplanetary emission spectra. Spectral retrieval of exoplanetary atmospheres frequently requires the preselection of molecular/atomic opacities to be defined by the user. In the era of open-source, automated, and self-sufficient retrieval algorithms, manual input should be avoided. User dependent input could, in worst-case scenarios, lead to incomplete models and biases in the retrieval. The RobERt algorithm is based on deep-belief neural (DBN) networks trained to accurately recognize molecular signatures for a wide range of planets, atmospheric thermal profiles, and compositions. Reconstructions of the learned features, also referred to as the “dreams” of the network, indicate good convergence and an accurate representation of molecular features in the DBN. Using these deep neural networks, we work toward retrieval algorithms that themselves understand the nature of the observed spectra, are able to learn from current and past data, and make sensible qualitative preselections of atmospheric opacities to be used for the quantitative stage of the retrieval process.

  9. The hunter becomes the hunted: when cleptobiotic insects are captured by their target ants

    NASA Astrophysics Data System (ADS)

    Dejean, Alain; Carpenter, James M.; Corbara, Bruno; Wright, Pamela; Roux, Olivier; LaPierre, Louis M.

    2012-04-01

    Here we show that trying to rob prey (cleptobiosis) from a highly specialized predatory ant species is risky. To capture prey, Allomerus decemarticulatus workers build gallery-shaped traps on the stems of their associated myrmecophyte, Hirtella physophora. We wondered whether the frequent presence of immobilized prey on the trap attracted flying cleptoparasites. Nine social wasp species nest in the H. physophora foliage; of the six species studied, only Angiopolybia pallens rob prey from Allomerus colonies. For those H. physophora not sheltering wasps, we noted cleptobiosis by stingless bees ( Trigona), social wasps ( A. pallens and five Agelaia species), assassin bugs (Reduviidae), and flies. A relationship between the size of the robbers and their rate of capture by ambushing Allomerus workers was established for social wasps; small wasps were easily captured, while the largest never were. Reduviids, which are slow to extract their rostrum from prey, were always captured, while Trigona and flies often escaped. The balance sheet for the ants was positive vis-à-vis the reduviids and four out of the six social wasp species. For the latter, wasps began by cutting up parts of the prey's abdomen and were captured (or abandoned the prey) before the entire abdomen was retrieved so that the total weight of the captured wasps exceeded that of the prey abdomens. For A. pallens, we show that the number of individuals captured during attempts at cleptobiosis increases with the size of the Allomerus' prey.

  10. High-pressure synthesis and crystal structure of silicon phosphate hydroxide, SiPO 4(OH)

    NASA Astrophysics Data System (ADS)

    Stearns, Linda A.; Groy, Thomas L.; Leinenweber, Kurt

    2005-09-01

    A new high-pressure phase, silicon phosphate hydroxide, was prepared at 8.3±0.5 GPa and 1000 °C in >98% purity. From X-ray diffraction on a pseudo-merohedrally twinned crystal, it was found that SiPO 4(OH) crystallizes in a monoclinic cell with space group P21/n (No. 14), a=6.8446(11) Å, b=6.8683(13) Å, c=6.8446(11) Å, β=119.77(1)∘, and Z=4. The refinement gave a conventional Robs of 0.0320 and wRobs of 0.0864 for the overlapped data from both twin components. In the structure, SiO 6 octahedra form chains along [101], with PO 4 tetrahedra alternating along the chain in the b-direction. The parallel chains link up with tetrahedral corners from other chains to form a 3-dimensional network. SiPO 4(OH) belongs to a structural family that includes HgSeO4·H2O. It is also related to the SbOPO 4 structure by a small distortion that lowers the symmetry from C2/c in SbOPO 4 to P21/c (P21/n) in SiPO 4(OH).

  11. SoxS-dependent coregulation of ompN and ydbK in a multidrug-resistant Escherichia coli strain.

    PubMed

    Fàbrega, Anna; Rosner, Judah L; Martin, Robert G; Solé, Mar; Vila, Jordi

    2012-07-01

    SoxS, MarA, and Rob are homologous transcriptional activators of numerous superoxide- and antibiotic resistance genes but many of the regulated genes are yet to be characterized. In this study, microarrays and RT-PCR analysis were used to show the overexpression of the ompN porin and its upstream gene, ydbK, in an Escherichia coli multidrug-resistant mutant and in a strain constitutive for SoxS. However, transcriptional fusions revealed that SoxS (not MarA or Rob) only activated the ydbK promoter but not the ompN upstream region. RT-PCR experiments showed the overexpression of a combined ydbK - ompN transcript in the SoxS-overexpressing strain. Surprisingly, a bioinformatic approach revealed no soxbox upstream of the ydbK promoter. Thus, the ydbK and ompN genes are coexpressed in an operon and are likely activated by SoxS indirectly. It is known that YdbK is involved in superoxide resistance. Thus, individual ompN and ydbK mutants were tested for superoxide susceptibility. Nonetheless, only the ydbK mutant was susceptible to paraquat, a superoxide generator. These mutants, as well as an OmpN-overproducing strain, were further tested for antibiotic resistance. No significant decreased susceptibility was observed. Thus, ydbK plays a role in superoxide resistance but no role for either gene is found in resistance to the antibiotics tested.

  12. Trauma experience among homeless female veterans: correlates and impact on housing, clinical, and psychosocial outcomes.

    PubMed

    Tsai, Jack; Rosenheck, Robert A; Decker, Suzanne E; Desai, Rani A; Harpaz-Rotem, Ilan

    2012-12-01

    This study examined lifetime exposure to traumatic events as reported by 581 homeless female veterans enrolled in a Homeless Women Veterans Program across 11 sites to characterize the types of trauma they experienced; their correlation with baseline characteristics; and their association with housing, clinical outcomes, and psychosocial functioning over a 1-year treatment period. Almost all participants endorsed multiple types and episodes of traumatic events. Among the most common were having someone close experience a serious or life-threatening illness (82%) and rape (67%). Exploratory factor analysis revealed 6 potential trauma categories: being robbed, experiencing accident or disasters, illness or death of others, combat, sexual assault, and physical assault. At baseline, trauma from sexual assault was associated with more days homeless (β = .18, p < .001), trauma from accidents or disasters was associated with poorer physical health (β = -.23, p < .001), and trauma from being robbed was related to greater use of drugs (β = .22, p < .001). Trauma reported at baseline, however, was not predictive of 1-year outcomes, suggesting type and frequency of trauma does not negatively affect the housing gains homeless women veterans can achieve through homeless services.

  13. The hunter becomes the hunted: when cleptobiotic insects are captured by their target ants.

    PubMed

    Dejean, Alain; Carpenter, James M; Corbara, Bruno; Wright, Pamela; Roux, Olivier; Lapierre, Louis M

    2012-04-01

    Here we show that trying to rob prey (cleptobiosis) from a highly specialized predatory ant species is risky. To capture prey, Allomerus decemarticulatus workers build gallery-shaped traps on the stems of their associated myrmecophyte, Hirtella physophora. We wondered whether the frequent presence of immobilized prey on the trap attracted flying cleptoparasites. Nine social wasp species nest in the H. physophora foliage; of the six species studied, only Angiopolybia pallens rob prey from Allomerus colonies. For those H. physophora not sheltering wasps, we noted cleptobiosis by stingless bees (Trigona), social wasps (A. pallens and five Agelaia species), assassin bugs (Reduviidae), and flies. A relationship between the size of the robbers and their rate of capture by ambushing Allomerus workers was established for social wasps; small wasps were easily captured, while the largest never were. Reduviids, which are slow to extract their rostrum from prey, were always captured, while Trigona and flies often escaped. The balance sheet for the ants was positive vis-à-vis the reduviids and four out of the six social wasp species. For the latter, wasps began by cutting up parts of the prey's abdomen and were captured (or abandoned the prey) before the entire abdomen was retrieved so that the total weight of the captured wasps exceeded that of the prey abdomens. For A. pallens, we show that the number of individuals captured during attempts at cleptobiosis increases with the size of the Allomerus' prey. PMID:22361902

  14. Economic and policy implications of pandemic influenza.

    SciTech Connect

    Smith, Braeton J.; Starks, Shirley J.; Loose, Verne W.; Brown, Theresa Jean; Warren, Drake E.; Vargas, Vanessa N.

    2010-03-01

    Pandemic influenza has become a serious global health concern; in response, governments around the world have allocated increasing funds to containment of public health threats from this disease. Pandemic influenza is also recognized to have serious economic implications, causing illness and absence that reduces worker productivity and economic output and, through mortality, robs nations of their most valuable assets - human resources. This paper reports two studies that investigate both the short- and long-term economic implications of a pandemic flu outbreak. Policy makers can use the growing number of economic impact estimates to decide how much to spend to combat the pandemic influenza outbreaks. Experts recognize that pandemic influenza has serious global economic implications. The illness causes absenteeism, reduced worker productivity, and therefore reduced economic output. This, combined with the associated mortality rate, robs nations of valuable human resources. Policy makers can use economic impact estimates to decide how much to spend to combat the pandemic influenza outbreaks. In this paper economists examine two studies which investigate both the short- and long-term economic implications of a pandemic influenza outbreak. Resulting policy implications are also discussed. The research uses the Regional Economic Modeling, Inc. (REMI) Policy Insight + Model. This model provides a dynamic, regional, North America Industrial Classification System (NAICS) industry-structured framework for forecasting. It is supported by a population dynamics model that is well-adapted to investigating macro-economic implications of pandemic influenza, including possible demand side effects. The studies reported in this paper exercise all of these capabilities.

  15. New Astrometric Reduction of the USNO Photographic Plates of Planetary Satellites

    NASA Astrophysics Data System (ADS)

    de Cuyper, J.-P.; Winter, L.; de Decker, G.; Zacharias, N.; Pascu, D.; Arlot, J.-E.; Robert, V.; Lainey, V.

    2009-09-01

    An international collaboration has been set up between the US Naval Observatory (USNO) in Washington DC, the IMCCE of Paris Observatory (OBSPM) and the Royal Observatory of Belgium (ROB) to make a new astrometric reduction of the USNO archival photographic plates of planetary satellites. In order to obtain a better knowledge of their orbital motions these photographic plates are digitized with the new generation DAMIAN digitizer at the ROB, providing a geometric stability of better than 0.1 μm on the plates. We focus here on a subset of a few hundred photographic plates of the Galilean satellites, taken with the McCormick and the USNO 26-inch refractors between 1967 and 1998. Specific procedures and algorithms are used to obtain highly accurate positions using the Tycho2, UCAC2 (20 - 30 mas) and later the UCAC3 (10 - 20 mas) catalogues. A comparison with the MAMA digitizer of the Paris Observatory is made through the results obtained from digital mosaic images of the plates.

  16. Suppression of the HPA axis stress-response: implications for relapse.

    PubMed

    Adinoff, Byron; Junghanns, Klaus; Kiefer, Falk; Krishnan-Sarin, Suchitra

    2005-07-01

    This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October 2004. This symposium explored the potential role of hypothalamic-pituitary-adrenal (HPA) axis dysregulation upon relapse. HPA axis stimulation induces the release of the glucocorticoid cortisol, a compound with profound effects upon behavior and emotion. Altered stress-responses of the HPA axis in abstinent alcohol-dependent subjects, therefore, may influence their affective and behavioral regulation, thus impacting their potential for relapse. Bryon Adinoff began the symposium with a review of HPA axis dysfunction in alcohol-dependent subjects, including recent studies from his lab demonstrating an attenuated glucocorticoid response to both endogenous and exogenous stimulation in one-month abstinent men. Klaus Junghanns presented his work demonstrating that a blunted ACTH or cortisol response to subjective stressors (social stressor or alcohol exposure) is predictive of a return to early drinking. The final two presenters examined the interaction between naltrexone and HPA responsiveness in alcohol-dependent or at-risk subjects, as naltrexone induces an increase in ACTH and cortisol. Falk Kiefer discussed the relationship between basal HPA axis responsivity and clinical outcome following treatment with naltrexone or acamprosate. Plasma ACTH significantly decreased over the course of the study in the placebo group, but not the medication groups [corrected] Lower basal concentrations of ACTH and cortisol were associated with quicker relapse in the placebo group only. Suchitra Krishnan-Sarin described her preliminary work, in which family-history positive (FH+) and family history negative (FH-) subjects were administered naltrexone, followed by an assessment of alcohol-induced craving. The cortisol response to alcohol was significantly and inversely related to craving in the FH+, but not

  17. F3D Image Processing and Analysis for Many - and Multi-core Platforms

    SciTech Connect

    2014-10-01

    F3D is written in OpenCL, so it achieve[sic] platform-portable parallelism on modern mutli-core CPUs and many-core GPUs. The interface and mechanims to access F3D core are written in Java as a plugin for Fiji/ImageJ to deliver several key image-processing algorithms necessary to remove artifacts from micro-tomography data. The algorithms consist of data parallel aware filters that can efficiently utilizes[sic] resources and can work on out of core datasets and scale efficiently across multiple accelerators. Optimizing for data parallel filters, streaming out of core datasets, and efficient resource and memory and data managements over complex execution sequence of filters greatly expedites any scientific workflow with image processing requirements. F3D performs several different types of 3D image processing operations, such as non-linear filtering using bilateral filtering and/or median filtering and/or morphological operators (MM). F3D gray-level MM operators are one-pass constant time methods that can perform morphological transformations with a line-structuring element oriented in discrete directions. Additionally, MM operators can be applied to gray-scale images, and consist of two parts: (a) a reference shape or structuring element, which is translated over the image, and (b) a mechanism, or operation, that defines the comparisons to be performed between the image and the structuring element. This tool provides a critical component within many complex pipelines such as those for performing automated segmentation of image stacks. F3D is also called a "descendent" of Quant-CT, another software we developed in the past. These two modules are to be integrated in a next version. Further details were reported in: D.M. Ushizima, T. Perciano, H. Krishnan, B. Loring, H. Bale, D. Parkinson, and J. Sethian. Structure recognition from high-resolution images of ceramic composites. IEEE International Conference on Big Data, October 2014.

  18. Direct evidence of three-body interactions in a cold {sup 85}Rb Rydberg gas

    SciTech Connect

    Han Jianing

    2010-11-15

    Cold Rydberg atoms trapped in a magneto-optical trap (MOT) are not isolated and they interact through dipole-dipole and multipole-multipole interactions. First-order dipole-dipole interactions and van der Waals interactions between two atoms have been intensively studied. However, the facts that the first-order dipole-dipole interactions and van der Waals interactions show the same size of broadening [A. Reinhard, K. C. Younge, T. C. Liebisch, B. Knuffman, P. R. Berman, and G. Raithel, Phys. Rev. Lett. 100, 233201 (2008)] and there are transitions between two dimer states [S. M. Farooqi, D. Tong, S. Krishnan, J. Stanojevic, Y. P. Zhang, J. R. Ensher, A. S. Estrin, C. Boisseau, R. Cote, E. E. Eyler, and P. L. Gould, Phys. Rev. Lett. 91, 183002 (2003); K. R. Overstreet, Arne Schwettmann, Jonathan Tallant, and James P. Shaffer, Phys. Rev. A 76, 011403(R) (2007)] cannot be explained by the two-atom picture. The purpose of this article is to show the few-body nature of a dense cold Rydberg gas by studying the molecular-state microwave spectra. Specifically, three-body energy levels have been calculated. Moreover, the transition from three-body energy levels to two-body coupled molecular energy levels and to isolated atomic energy levels as a function of the internuclear spacing is studied. Finally, single-body, two-body, and three-body interaction regions are estimated according to the experimental data. The results reported here provides useful information for plasma formation, further cooling, and superfluid formation.

  19. Direct evidence of three-body interactions in a cold Rb85 Rydberg gas

    NASA Astrophysics Data System (ADS)

    Han, Jianing

    2010-11-01

    Cold Rydberg atoms trapped in a magneto-optical trap (MOT) are not isolated and they interact through dipole-dipole and multipole-multipole interactions. First-order dipole-dipole interactions and van der Waals interactions between two atoms have been intensively studied. However, the facts that the first-order dipole-dipole interactions and van der Waals interactions show the same size of broadening [A. Reinhard, K. C. Younge, T. C. Liebisch, B. Knuffman, P. R. Berman, and G. Raithel, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.100.233201 100, 233201 (2008)] and there are transitions between two dimer states [S. M. Farooqi, D. Tong, S. Krishnan, J. Stanojevic, Y. P. Zhang, J. R. Ensher, A. S. Estrin, C. Boisseau, R. Cote, E. E. Eyler, and P. L. Gould, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.91.183002 91, 183002 (2003); K. R. Overstreet, Arne Schwettmann, Jonathan Tallant, and James P. Shaffer, Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.76.011403 76, 011403(R) (2007)] cannot be explained by the two-atom picture. The purpose of this article is to show the few-body nature of a dense cold Rydberg gas by studying the molecular-state microwave spectra. Specifically, three-body energy levels have been calculated. Moreover, the transition from three-body energy levels to two-body coupled molecular energy levels and to isolated atomic energy levels as a function of the internuclear spacing is studied. Finally, single-body, two-body, and three-body interaction regions are estimated according to the experimental data. The results reported here provides useful information for plasma formation, further cooling, and superfluid formation.

  20. Response of Nereis diversicolor (Polychaeta, Nereidae) populations to reduced wastewater discharge in the polluted estuary of Oued Souss, Bay of Agadir, Morocco

    NASA Astrophysics Data System (ADS)

    Ait Alla, A.; Gillet, P.; Deutsch, B.; Moukrim, A.; Bergayou, H.

    2006-12-01

    Field investigations on the population dynamics of Nereis diversicolor were carried out from January 2002 to December 2003 in the estuary of Oued Souss (southwestern Morocco) to determine the changes caused by setting up of a domestic and industrial wastewater purification plant (M'zar) before and after by the end of wastewater discharges in November 2002 on the structure of the ecosystem. Samples of N. diversicolor were collected monthly in the intertidal zone at low tide before (during 2002) and after (during 2003) the end of wastewater discharges. Separation of cohorts using the Algorithm EM method (McLachlan, G.J., Krishnan, T., 1997. The EM algorithm and extensions. Wiley Series in Probability and Statistics. Wiley, New York, 274 pp.) allowed determination of the growth rate (mm day -1) by cohort and the annual production. The data showed significant differences between populations of Nereis diversicolor before and after the end of wastewater discharges. During the wastewater discharge period (2002), the population had a mean annual density of 1992 ind m -2, a mean annual biomass of 75.52 g DW m -2 and an annual secondary production of 141.3 g DW m -2 with a P/ B ratio of 1.87. After the end of discharges (2003), density, biomass and secondary production decreased significantly. The annual averages for these parameters were 740 ind m -2, 14.16 g DW m -2 and 23.83 g DW m -2, respectively, with a P/ B ratio of 1.68. The important decrease observed in density, biomass and secondary production of Nereis diversicolor may be attributed (a) to the environmental changes observed after the end of wastewater discharges in the estuary of Oued Souss, namely the increase of salinity and the decrease of organic matter content, and (b) to the migration of this species towards other areas.

  1. A novel Robertsonian translocation event leads to transfer of a stem rust resistance gene (Sr52) effective against race Ug99 from Dasypyrum villosum into bread wheat.

    PubMed

    Qi, L L; Pumphrey, M O; Friebe, Bernd; Zhang, P; Qian, C; Bowden, R L; Rouse, M N; Jin, Y; Gill, B S

    2011-06-01

    Stem rust (Puccinia graminis f. sp. tritici Eriks. & E. Henn.) (the causal agent of wheat stem rust) race Ug99 (also designated TTKSK) and its derivatives have defeated several important stem rust resistance genes widely used in wheat (Triticum aestivum L.) production, rendering much of the worldwide wheat acreage susceptible. In order to identify new resistance sources, a large collection of wheat relatives and genetic stocks maintained at the Wheat Genetic and Genomic Resources Center was screened. The results revealed that most accessions of the diploid relative Dasypyrum villosum (L.) Candargy were highly resistant. The screening of a set of wheat-D. villosum chromosome addition lines revealed that the wheat-D. villosum disomic addition line DA6V#3 was moderately resistant to race Ug99. The objective of the present study was to produce and characterize compensating wheat-D. villosum whole arm Robertsonian translocations (RobTs) involving chromosomes 6D of wheat and 6V#3 of D. villosum through the mechanism of centric breakage-fusion. Seven 6V#3-specific EST-STS markers were developed for screening F(2) progeny derived from plants double-monosomic for chromosomes 6D and 6V#3. Surprisingly, although 6D was the target chromosome, all recovered RobTs involved chromosome 6A implying a novel mechanism for the origin of RobTs. Homozygous translocations (T6AS·6V#3L and T6AL·6V#3S) with good plant vigor and full fertility were selected from F(3) families. A stem rust resistance gene was mapped to the long arm 6V#3L in T6AS·6V#3L and was designated as Sr52. Sr52 is temperature-sensitive and is most effective at 16°C, partially effective at 24°C, and ineffective at 28°C. The T6AS·6V#3L stock is a new source of resistance to Ug99, is cytogenetically stable, and may be useful in wheat improvement.

  2. Effect of Antimicrobial Exposure on AcrAB Expression in Salmonella enterica Subspecies enterica Serovar Choleraesuis

    PubMed Central

    Usui, Masaru; Nagai, Hidetaka; Hiki, Mototaka; Tamura, Yutaka; Asai, Tetsuo

    2013-01-01

    Understanding the impact of antimicrobial use on the emergence of resistant bacteria is imperative to prevent its emergence. For instance, activation of the AcrAB efflux pumps is responsible for the emergence of antimicrobial-resistant Salmonella strains. Here, we examined the expression levels of acrB and its multiple regulator genes (RamA, SoxS, MarA, and Rob) in 17 field isolates of S. Choleraesuis by using quantitative PCR methods. The expression of acrB increased in eight of the field isolates (P < 0.05). The expression of acrB was associated with that of ramA in one isolate, soxS in one isolate, and both these genes in six isolates. Thereafter, to examine the effect of selected antimicrobials (enrofloxacin, ampicillin, oxytetracycline, kanamycin, and spectinomycin) on the expression of acrB and its regulator genes, mutants derived from five isolates of S. Choleraesuis were selected by culture on antimicrobial-containing plates. The expression of acrB and ramA was higher in the mutants selected using enrofloxacin (3.3–6.3- and 24.5–37.7-fold, respectively), ampicillin (1.8–7.7- and 16.1–55.9-fold, respectively), oxytetracycline (1.7–3.3- and 3.2–31.1-fold, respectively), and kanamycin (1.6–2.2- and 5.6–26.4-fold, respectively), which are AcrAB substrates, than in each of the parental strains (P < 0.05). In contrast, in AcrAB substrate-selected mutants, the expression of soxS, marA, and rob remained similar to that in parental strains. Of the four antimicrobials, the level of ramA expression was significantly higher in the enrofloxacin- and ampicillin-selected mutants than in the oxytetracycline- and kanamycin-selected mutants (P < 0.05), whereas the expression levels of acrB and multiple regulator genes in spectinomycin-selected mutants were similar to those in each parental strain. These data suggest that exposure to antimicrobials that are AcrAB substrates enhance the activation of the AcrAB efflux pump via RamA, but not via Sox

  3. Candidates for GRL North American coeditor sought

    NASA Astrophysics Data System (ADS)

    Geophysical Research Letters (GRL), AGU's all-Union primary research journal, is seeking candidates and nominations for candidates to succeed Rob Van der Voo, whose term as North American Coeditor ends December 31, 1986. The successful candidate will be challenged to seek out interesting papers at the forefront of the geophysical sciences and to attempt to strike a balance in the publication of that science that is of interest to the entire AGU membership. While complementing the interests of Editor in Chief Alex Dessler, the successful candidate will also be challenged to maintain rapid publication time and minimize the publication of research that is routine. The North American Coeditor should be prepared to welcome controversial research papers that challenge conventional wisdom in all fields of interest to AGU. The individual selected for this prestigious position will have a vital role in making GRL an even more important and more exciting journal that readers look forward to receiving each month.

  4. Medical practice branding using cable television.

    PubMed

    Miaoulis, George; Kissinger, Mark; Sirko-Fiorilli, Mary Ann

    2005-01-01

    Genesis Medical Associates is an independent primary care practice in the suburbs of Pittsburgh. Given competitive pressures, a member of the physician leadership began thinking about the need for the practice to develop an "identity and awareness" program to set the practice apart from the competition. The idea for branding the campaign began when Dr. Rob Potter, Jr., was attending a Pittsburgh Pirates baseball game and a fan said to him, "You're that doctor I see on television" in the nursing home commercial. Triggered by this experience, Potter saw the opportunity to develop an awareness and identity campaign for Genesis. In this article we share the reasons for, the steps taken, and initial results in developing a medical practice branding strategy.

  5. First Results of the TIGRE Chromospheric Activity Survey

    NASA Astrophysics Data System (ADS)

    Mittag, M.; Hempelmann, A.; Gonzalez-Perez, J. N.; Schmitt, J. H. M. M.

    2015-01-01

    We present the first results of the stellar activity survey with TIGRE (Telescopio Internacional de Guanajuato, Robótico-Espectroscópico). This long term program was started in August 2013 with the monitoring of a larger number of stars. We aim at measuring the short- and long-term variability of stellar activity for stars of different spectral types and luminosity classes, using indicators of different spectral lines (mainly Ca II S-Index, Ca II IR triplet, H_α and sodium D). A transformation equation of the TIGRE S-Index into the Mount Wilson S-index was derived in order to compare our results to the vast body of existing S-index measurements. Furthermore, the correlation between the S-index and the lines of the Ca II IR triplet has been studied, based on strictly simultaneous observations.

  6. SitePainter: a tool for exploring biogeographical patterns

    PubMed Central

    Gonzalez, Antonio; Stombaugh, Jesse; Lauber, Christian L.; Fierer, Noah; Knight, Rob

    2012-01-01

    As microbial ecologists take advantage of high-throughput analytical techniques to describe microbial communities across ever-increasing numbers of samples, the need for new analysis tools that reveal the intrinsic spatial patterns and structures of these populations is crucial. Here we present SitePainter, an interactive graphical tool that allows investigators to create or upload pictures of their study site, load diversity analyses data and display both diversity and taxonomy results in a spatial context. Features of SitePainter include: visualizing α -diversity, using taxonomic summaries; visualizing β -diversity, using results from multidimensional scaling methods; and animating relationships among microbial taxa or pathways overtime. SitePainter thus increases the visual power and ability to explore spatially explicit studies. Availability: https://sourceforge.net/projects/sitepainter Supplementary information: Supplementary data are available at Bioinformatics online. Contact: antoniog@colorado.edu, Rob.Knight@colorado.edu PMID:22171330

  7. Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes

    SciTech Connect

    Lowden, Michael J.; Skorupski, Karen; Pellegrini, Maria; Chiorazzo, Michael G.; Taylor, Ronald K.; Kull, F. Jon

    2010-03-04

    Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have solved the 1.9 {angstrom} resolution crystal structure of ToxT, which reveals folds in the N- and C-terminal domains that share a number of features in common with AraC, MarA, and Rob as well as the unexpected presence of a buried 16-carbon fatty acid, cis-palmitoleate. The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.

  8. Pulling up the runaway: the effect of new evidence on euthanasia's slippery slope.

    PubMed Central

    Ryan, C J

    1998-01-01

    The slippery slope argument has been the mainstay of many of those opposed to the legalisation of physician-assisted suicide and euthanasia. In this paper I re-examine the slippery slope in the light of two recent studies that examined the prevalence of medical decisions concerning the end of life in the Netherlands and in Australia. I argue that these two studies have robbed the slippery slope of the source of its power--its intuitive obviousness. Finally I propose that, contrary to the warnings of the slippery slope, the available evidence suggests that the legalisation of physician-assisted suicide might actually decrease the prevalence of non-voluntary and involuntary euthanasia. PMID:9800591

  9. Spatially and Temporally Resolved Studies of the Human Microbiome (2011 JGI User Meeting)

    ScienceCinema

    Knight, Rob [University of Colorado

    2016-07-12

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Rob Knight of the University of Colorado gives a presentation on "Spatially and Temporally Resolved Studies of the Human Microbiome" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  10. Playing the game: psychological factors in surviving cancer.

    PubMed

    Rom, Stephen A; Miller, Laurence; Peluso, Jennifer

    2009-01-01

    Cancer is a threat that can rob a person of their physical and mental wellbeing. While cancer awareness has ventured to the forefront of social consciousness, led by surges from Lance Armstrong and other celebrities affected by cancer, the medical world continually remains foiled in terms of regulating the many confounding variables that spawn cancer: toxins, pollutants, poor diet, etc. Yet there is a hope: one variable thought to affect cancer prognosis may be distinctly tractable: positive mental attitude (PMA). Principles of PMA that are readily utilized in the science of sports psychology to spur athletes to victory may be productively applied to the hospital arena. The parallels between sports and medicine are abundant, and can be utilized by the cancer patient to help secure victory. This paper describes the steps to victory, along with stratagems and concepts on how to keep the "opponent"--cancer--from gaining any further advantage.

  11. Modeling organic aerosols in a megacity: potential contribution of semi-volatile and intermediate volatility primary organic compounds to secondary organic aerosol formation

    SciTech Connect

    Hodzic, Alma; Jimenez, Jose L.; Madronich, Sasha; Canagaratna, M. R.; DeCarlo, Peter F.; Kleinman, Lawrence I.; Fast, Jerome D.

    2010-06-21

    It has been established that observed local and regional levels of secondary organic aerosols (SOA) in polluted areas cannot be explained by the oxidation and partitioning of traditional anthropogenic and biogenic VOC precursors. In this study, the 3D regional air quality model CHIMERE is applied to quantify the contribution to SOA formation of recently identified semi-volatile and intermediate volatility organic vapors (S/IVOC) in and around Mexico City for the MILAGRO field experiment during March 2006. The model has been updated to explicitly include the volatility distribution of primary organic aerosols (POA), their gas-particle partitioning and the gas-phase oxidation of the vapors. Two recently proposed parameterizations, those of Robinson et al. (2007) ("ROB") and Grieshop et al. (2009) ("GRI") are compared and evaluated against surface and aircraft measurements. For the first time, 3D model results are assessed by comparing with the concentrations of OA components from Positive Matrix Factorization of Aerosol Mass Spectrometer (AMS) data, but also against and oxygen-to-carbon ratios derived from high-resolution AMS measurements. The results show a substantial enhancement in predicted SOA concentrations (3-6 times) with respect to the previously published base case without S/IVOCs (Hodzic et al., 2009), both within and downwind of the city leading to much reduced discrepancies with the total OA measurements. The predicted anthropogenic POA levels are found to agree within 20% with the observed HOA concentrations for both the ROB and GRI simulations, consistent with the interpretation of the emissions inventory by previous studies. The impact of biomass burning POA within the city is underestimated in comparison to the AMS BBOA, presumably due to insufficient nighttime smoldering emissions. Model improvements in OA predictions are associated with the better-captured SOA magnitude and diurnal variability. The production from anthropogenic and biomass burning

  12. Potential contribution of semi-volatile and intermediate volatility primary organic compounds to secondary organic aerosol in the Mexico City region

    SciTech Connect

    Hodzic, A.; Kleinman, L.; Jimenez, J. L.; Madronich, S.; Canagaratna, M. R.; DeCarlo, P. F.; Fast, J.

    2010-03-01

    It has been established that observed local and regional levels of secondary organic aerosols (SOA) in polluted areas cannot be explained by the oxidation and partitioning of anthropogenic and biogenic VOC precursors, at least using current mechanisms and parameterizations. In this study, the 3-D regional air quality model CHIMERE is applied to quantify the contribution to SOA formation of recently identified semi-volatile and intermediate volatility organic vapors (S/IVOC) in and around Mexico City for the MILAGRO field experiment during March 2006. The model has been updated to include explicitly the volatility distribution of primary organic aerosols (POA), their gas-particle partitioning and the gas-phase oxidation of the vapors. Two recently proposed parameterizations, those of Robinson et al. (2007) ('ROB') and Grieshop et al. (2009) ('GRI') are compared and evaluated against surface and aircraft measurements. The 3-D model results are assessed by comparing with the concentrations of OA components from Positive Matrix Factorization of Aerosol Mass Spectrometer (AMS) data, and for the first time also with oxygen-to-carbon ratios derived from high-resolution AMS measurements. The results show a substantial enhancement in predicted SOA concentrations (3–6 times) with respect to the previously published base case without S/IVOCs (Hodzic et al., 2009), both within and downwind of the city leading to much reduced discrepancies with the total OA measurements. The predicted anthropogenic POA levels are found to agree within 20% with the observed HOA concentrations for both the ROB and GRI simulations, consistent with the interpretation of the emissions inventory by previous studies. The impact of biomass burning POA within the city is underestimated in comparison to the AMS BBOA, presumably due to insufficient nighttime smoldering emissions. Model improvements in OA predictions are associated with the better-captured SOA magnitude and diurnal variability. The

  13. Coping with paradoxes of risk communication: Observations and suggestions

    SciTech Connect

    Johnson, B.B. )

    1993-06-01

    The maturation of the field of risk communication has resulted in several manuals, a National Research Council review, a Society for Risk Analysis subgroup, and critics. Critics Pieter-Jan Stalen and Rob Coppock, and Harry Otway and Brian Wynne, have pointed out that much risk communication is impractical or paradoxical. In this letter, the author supports many of the criticisms of these critics, but also discusses errors and omissions in their viewpoints that he feels will inhibit progress in effective risk communication. Topics discussed are motivations for risk communication, the practicality of advice, the audience for risk communication, credibility, and whose interests are best served by risk communication. The purpose of this essay is therefore to spur further debate on the issue of risk communication. 13 refs.

  14. Solar sail Engineering Development Mission

    NASA Technical Reports Server (NTRS)

    Price, H. W.

    1981-01-01

    Since photons have momentum, a useful force can be obtained by reflecting sunlight off of a large, low mass surface (most likely a very thin metal-coated plastic film) and robbing the light of some of its momentum. A solar sail Engineering Development Mission (EDM) is currently being planned by the World Space Foundation for the purpose of demonstrating and evaluating solar sailing technology and to gain experience in the design and operation of a spacecraft propelled by sunlight. The present plan is for the EDM spacecraft to be launched (sail stowed) in a spin-stabilized configuration into an initial elliptical orbit with an apogee of 36,000 km and a perigee of a few hundred kilometers. The spacecraft will then use its own chemical propulsion system to raise the perigee to at least 1,200 km. The deployed sail will have an area of 880 sq m and generate a solar force of about 0.007 N.

  15. Gear Windage Modeling Progress - Experimental Validation Status

    NASA Technical Reports Server (NTRS)

    Kunz, Rob; Handschuh, Robert F.

    2008-01-01

    In the Subsonics Rotary Wing (SRW) Project being funded for propulsion work at NASA Glenn Research Center, performance of the propulsion system is of high importance. In current rotorcraft drive systems many gearing components operate at high rotational speed (pitch line velocity > 24000 ft/ min). In our testing of high speed helical gear trains at NASA Glenn we have found that the work done on the air - oil mist within the gearbox can become a significant part of the power loss of the system. This loss mechanism is referred to as windage. The effort described in this presentation is to try to understand the variables that affect windage, develop a good experimental data base to validate, the analytical project being conducted at Penn State University by Dr. Rob Kunz under a NASA SRW NRA. The presentation provides an update to the status of these efforts.

  16. Quantum decoherence in noninertial frames

    SciTech Connect

    Wang Jieci; Jing Jiliang

    2010-09-15

    Quantum decoherence, which appears when a system interacts with its environment in an irreversible way, plays a fundamental role in the description of quantum-to-classical transitions and has been successfully applied in some important experiments. Here, we study the decoherence in noninertial frames. It is shown that the decoherence and loss of the entanglement generated by the Unruh effect will influence each other remarkably. It is interesting to note that, in the case of the total system under decoherence, the sudden death of entanglement may appear for any acceleration. However, in the case of only Rob's qubit undergoing decoherence, sudden death may only occur when the acceleration parameter is greater than a 'critical point'.

  17. Discrete Differential Forms: A Novel Methodology for Robust Computational Electromagnetics

    SciTech Connect

    Castillo, P; Koning, J; Rieben, R; Stowell, M; White, D A

    2003-01-17

    This is the final report for the LLNL LDRD 01-LW-068. The Principle Investigator was Daniel White of the Center for Applied Scientific Computing (CASC). Collaborators included Paul Castillo and Mark Stowell of CASC, and Ph.D students Joe Koning and Rob Rieben of UC Davis. Some of the simulation results in this report were partially funded by a Defense Advanced Research Projects Agency research grant, and the two Ph.D. students were supported by the LLNL Student-Employee Graduate Research Fellow program. We begin with a short Administrative Overview which describes the motivation, scope, and deliverables of this research effort. Then follows the Technical section, which introduces the theory behind our Discrete Differential Forms approach, provides an overview of our FEMSTER C++ class library, and concludes with example simulations.

  18. Higher-Order Mixed Finite Element Methods for Time Domain Electromagnetics

    SciTech Connect

    White, D; Stowell, M; Koning, J; Rieben, R; Fisher, A; Champagne, N; Madsen, N

    2004-02-06

    This is the final report for LDRD 01-ERD-005. The Principal Investigator was Niel Madsen of the Defense Sciences Engineering Division (DSED). Collaborators included Daniel White, Joe Koning and Nathan Champagne of DSED, Mark Stowell of Center for Applications Development and Software Engineering (CADSE), and Ph.D. students Rob Rieben and Aaron Fisher at the UC Davis Department of Applied Science. It should be noted that the students were partially supported by the LLNL Student-Employee Graduate Research Fellow program. We begin with an Introduction which provides background and motivation for this research effort. Section II contains high-level description of our Approach, and Section III summarizes our key research Accomplishments. A description of the Software deliverables is provided in Section IV, and Section V includes simulation Validation and Results. It should be noted we do not get into the mathematical details in this report, rather these can be found in our publications which are listed in Section III.

  19. Pro-Nuclear Environmentalism: Should We Learn to Stop Worrying and Love Nuclear Energy?

    PubMed

    van Munster, Rens; Sylvest, Casper

    2015-10-01

    In light of repeated failures to reach political agreement on effective policies to combat climate change, pro-nuclear environmentalists have set out to reverse the traditionally anti-nuclear inclinations of environmentalists. This essay examines the ideological commitments and assumptions of pro-nuclear environmentalism by performing a critical, historical analysis of the nuclear-environment nexus through the prism of documentary film. We focus on the work and career of documentary filmmaker Rob Stone, whose most recent production, Pandora's Promise (PP) (2013), has emerged as a central statement of this creed. PP actively forges a new political imaginary that replaces the apocalyptic image of nuclear fallout with that of catastrophic climate change. In terms of its rhetorical and visual strategies, however, PP also reveals that pro-nuclear environmentalist arguments have a long lineage. A close study of such continuities reveals a number of political implications that call for reflection as well as caution.

  20. The origin of the moon: Further studies of the giant impact

    NASA Technical Reports Server (NTRS)

    Benz, W.; Cameron, A. G. W.; Melosh, H. J.; Benz, W.

    1988-01-01

    A number of technical improvements in the calculations which simulate the most violent event that has occurred to the earth during its history: its collision with the next largest body which was present in its region of accumulation in the early solar system, are discussed. This body was a planet in its own right, an object a little more massive than the planet Mars. The collision created a disk of molten and gaseous debris in orbit around the protoearth, and it is believed that the dissipation of this disk resulted in the formation of the moon. Also discussed is the serendipitous discovery that has emerged from the simulations: the role played by a huge, hot, rotating bar of rock and iron, which is formed immediately after the collision, in transferring angular momentum to much of the rock that is put into orbit, and in robbing the iron of angular momentum so that it falls promptly into the protoearth.

  1. Kenneth Fitzpatrick Russell: the first reader to the Gordon Craig Library.

    PubMed

    Burke, P F

    1997-08-01

    A review of the life and achievements of Kenneth Fitzpatrick Russell, whose death in his 76th year robbed us of a civilized gentleman who was at the zenith of his creative output, would be a daunting task, if only because of the breadth of his hobbies and interests: art and medical literature; reading; sinology and seal carving; numismatics, medical philately; bookbinding, collecting bookplates; carpentry; metal work, including pewter casting and silversmithing; model ship building and cooking. Yet these various interests were simply a backdrop to his public career at the University of Melbourne and the Royal Australasian College of Surgeons, where he laid the foundations of an international reputation as scholar and collector.

  2. Oxfordian-Kimmeridgian (Late Jurassic) reservoir sandstones in the Witch Ground Graben, U. K. North Sea

    SciTech Connect

    Harker, S.D. Ltd., Aberdeen ); Mantel, K.A. ); Morton, D.J. ); Riley, L.A. )

    1991-03-01

    Oil-bearing Late Jurassic Oxfordian-Kimmeridgian sandstones of the Sgiath and Piper formations are of major economic importance in the Witch Ground Graben. They form the reservoirs in Scott, which in 1993 will be the largest producing North Sea oil field to come on stream for more than a decade. Together with Scott, the Piper, Saltire, Tartan, Highlander, Petronella, Rob Roy, and Ivanhoe fields contained almost 2 Bbbl of recoverable reserves in these formations. The Sgiath and Piper represent two phases of Late Jurassic transgression and regression, initially represented by paralic deposited sand culminating in a wave-dominated delta sequence. The history of the Sgiath and Piper formations is reviewed and lithostratigraphic and biostratigraphic correlations presented to illustrate the distribution of the reservoir sandstones.

  3. Noodle-map chaos - A simple example

    NASA Astrophysics Data System (ADS)

    Roessler, O. E.; Hudson, J. L.; Farmer, J. D.

    Chaos-generating folded two-dimensional maps can be generalized to higher dimensions in two ways: as folded-towel (or pancake) maps and as bent-walking-stick (or noddle) maps. The noodle case is of mathematical interest because the topologically one-dimensional attractors involved may, despite their thinness, be of the 'non-sink' type (that is, stand in a bijective relation to their domain of attraction). Moreover, Shtern recently showed that the well-known Kaplan-Yorke conjecture on the fractal dimensionality of chaotic attractors may fail in the case of noodle maps. We present here an explicit 3-variable noodle map with constant divergence (constant Jacobian determinant). The example is a higher analogue to the Henon diffeomorphism. A map of similar shape was recently found experimentally by Rob Shaw in a study of the irregularly dripping faucet.

  4. Medical humanities and philosophy: is the universe expanding or contracting?

    PubMed

    Stempsey, William E

    2007-12-01

    The question of whether the universe is expanding or contracting serves as a model for current questions facing the medical humanities. The medical humanities might aptly be described as a metamedical multiverse encompassing many separate universes of discourse, the most prominent of which is probably bioethics. Bioethics, however, is increasingly developing into a new interdisciplinary discipline, and threatens to engulf the other medical humanities, robbing them of their own distinctive contributions to metamedicine. The philosophy of medicine considered as a distinct field of study has suffered as a result. Indeed, consensus on whether the philosophy of medicine even constitutes a legitimate field of study is lacking. This paper presents an argument for the importance of a broad conception of the philosophy of medicine and the central role it should play in organizing and interpreting the various fields of study that make up the metamedical multiverse.

  5. Error-corrected quantum annealing with hundreds of qubits.

    PubMed

    Pudenz, Kristen L; Albash, Tameem; Lidar, Daniel A

    2014-01-01

    Quantum information processing offers dramatic speedups, yet is susceptible to decoherence, whereby quantum superpositions decay into mutually exclusive classical alternatives, thus robbing quantum computers of their power. This makes the development of quantum error correction an essential aspect of quantum computing. So far, little is known about protection against decoherence for quantum annealing, a computational paradigm aiming to exploit ground-state quantum dynamics to solve optimization problems more rapidly than is possible classically. Here we develop error correction for quantum annealing and experimentally demonstrate it using antiferromagnetic chains with up to 344 superconducting flux qubits in processors that have recently been shown to physically implement programmable quantum annealing. We demonstrate a substantial improvement over the performance of the processors in the absence of error correction. These results pave the way towards large-scale noise-protected adiabatic quantum optimization devices, although a threshold theorem such as has been established in the circuit model of quantum computing remains elusive.

  6. Kenneth Fitzpatrick Russell: the first reader to the Gordon Craig Library.

    PubMed

    Burke, P F

    1997-08-01

    A review of the life and achievements of Kenneth Fitzpatrick Russell, whose death in his 76th year robbed us of a civilized gentleman who was at the zenith of his creative output, would be a daunting task, if only because of the breadth of his hobbies and interests: art and medical literature; reading; sinology and seal carving; numismatics, medical philately; bookbinding, collecting bookplates; carpentry; metal work, including pewter casting and silversmithing; model ship building and cooking. Yet these various interests were simply a backdrop to his public career at the University of Melbourne and the Royal Australasian College of Surgeons, where he laid the foundations of an international reputation as scholar and collector. PMID:9287914

  7. Isolation and characterization of new ceramides from aerial parts of Lepidaploa cotoneaster.

    PubMed

    dos Santos, Edlene O; Meira, Marilena; do Vale, Ademir E; David, Jorge M; de Queiróz, Luciano P; David, Juceni P

    2012-06-01

    Two new ceramides were isolated from the bulbs of Lepidaploa cotoneaster (Willd. ex Spreng.) H. Rob. [Vernonia cotoneaster (Willd. ex Spreng.) Less.)], in addition to germanicol, beta-sitosterol, stigmasterol, 3-beta-O-beta-D-glucopyranosyl-sitosterol, lupeol, lupeoyl acetate and tiliroside. The structures of the new compounds were elucidated by spectral techniques (MS, 1H NMR, 13C NMR, HSQC, HMBC, DEPT, and TOCSY) and were compared with data reported in literature, and were established as 2S*,2'R*,3S*,4R*,11E)-N-[2'-hydroxyhenicosanoyl]-2-amino-nonadec-11-ene-1,3,4-triol (1) and (2S*,2'R*,3S*,4R*,8E)-N-[2'-hydroxytricosanoyl]-2-amino-nonadec-8-ene-1,3,4-triol (2). To establish the structure and to locate the double bond, the methyl ester of the fatty acid and dimethyl disulfide (DMDS) derivatives were prepared for both ceramides.

  8. [The medicines intended for internal use in the Formulary of Mons of 1755].

    PubMed

    Plouvier, L

    1999-01-01

    The Formulary of Mons of 1755 was in use but for 14 years. As a matter of fact, it was adopted in flagrant violation of the centralising measures promulgated by the Empress Maria Theresa who had endeavoured to impose on the entire territory of the southern Low Countries the Vienese Dispensarium, a version of which was published in Brussels in 1747. The medicines intended for internal use appearing in the Formulary of Mons are divided into two categories, namely operationes chimicae and compositiones galenicae. The former comprise of formulae alluding, on the one hand, to substances proper to alchemy (such as mercury and antimony), and, on the other, to substances derived form the techniques in current use of alchemy, namely sales, flores, distilled waters, tinctura and spiriti. Among the latter, several categories of mediciens appear prominently: the category of electuaria, loochs and conservae, that of mellitae, syrops, robs and extracts and that of tablets, trochisci, pills and powders. All these are treated therein.

  9. Mechanical defenses of plant extrafloral nectaries against herbivory

    PubMed Central

    Gish, Moshe; Mescher, Mark C.; De Moraes, Consuelo M.

    2016-01-01

    ABSTRACT Extrafloral nectaries play an important role in plant defense against herbivores by providing nectar rewards that attract ants and other carnivorous insects. However, extrafloral nectaries can themselves be targets of herbivory, in addition to being exploited by nectar-robbing insects that do not provide defensive services. We recently found that the extrafloral nectaries of Vicia faba plants, as well as immediately adjacent tissues, exhibit high concentrations of chemical toxins, apparently as a defense against herbivory. Here we report that the nectary tissues of this plant also exhibit high levels of structural stiffness compared to surrounding tissues, likely due to cell wall lignification and the concentration of calcium oxalate crystals in nectary tissues, which may provide an additional deterrent to herbivore feeding on nectary tissues. PMID:27489584

  10. Reproductive cloning, genetic engineering and the autonomy of the child: the moral agent and the open future

    PubMed Central

    Mameli, M

    2007-01-01

    Some authors have argued that the human use of reproductive cloning and genetic engineering should be prohibited because these biotechnologies would undermine the autonomy of the resulting child. In this paper, two versions of this view are discussed. According to the first version, the autonomy of cloned and genetically engineered people would be undermined because knowledge of the method by which these people have been conceived would make them unable to assume full responsibility for their actions. According to the second version, these biotechnologies would undermine autonomy by violating these people's right to an open future. There is no evidence to show that people conceived through cloning and genetic engineering would inevitably or even in general be unable to assume responsibility for their actions; there is also no evidence for the claim that cloning and genetic engineering would inevitably or even in general rob the child of the possibility to choose from a sufficiently large array of life plans. PMID:17264194

  11. Panel Discussion I. Star Formation in Galaxies: How Do We Continue?

    NASA Astrophysics Data System (ADS)

    Knapen, J. H.

    2008-06-01

    This is the written account of the first of two panel discussions, on Star formation in galaxies: how do we continue? The chair of the panel was Phil James, and panel members were John Beckman, Torsten Böker, Daniela Calzetti, Angeles Díaz, and Rob Kennicutt. The panel and audience discussed the following four questions: 1) What are the most critically needed techniques to give accurate measurements of total rates and efficiencies of star formation? 2) Do we understand the form of the initial mass function and its variation as a function of redshift and environment? 3) Are there multiple modes of star formation in galaxies (bulge vs disk, burst vs continuous) or does the Schmidt law explain everything? 4) How do we bring together our understanding of star formation in our Galaxy and in external systems?

  12. Spatially and Temporally Resolved Studies of the Human Microbiome (2011 JGI User Meeting)

    SciTech Connect

    Knight, Rob

    2011-03-23

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Rob Knight of the University of Colorado gives a presentation on "Spatially and Temporally Resolved Studies of the Human Microbiome" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  13. A symmetric terahertz graphene-based hybrid plasmonic waveguide

    NASA Astrophysics Data System (ADS)

    Chen, Ming; Sheng, Pengchi; Sun, Wei; Cai, Jianjin

    2016-10-01

    A graphene-based hybrid plasmonic waveguide (GHPW) structure, which works on the terahertz frequency and includes two identical cylinder robs symmetrically put on each side of graphene sheet with gaps g, has been proposed and investigated. The present waveguide not only significantly improves the propagation length but also maintains a compact mode area, which is due to the coupling between the dielectric waveguide mode and plasmonic mode. The graphene plasmons particularly differ from plasmons in noble metals of which propagation loss can be tuned by adjusting the Fermi energy level or carrier mobility. With a very good Fermi energy level and carrier mobility, a typical propagation length of 26.7 mm, and mode area of optical field of approximately 4 μm2 at 10 THz are achieved. This waveguide structure shows great promise for designing kinds of functional elements in actively tunable integrated optical devices.

  14. Ducted Fan Designs Lead to Potential New Vehicles

    NASA Technical Reports Server (NTRS)

    2010-01-01

    In 1994, aerospace engineers Rob Bulaga and Mike Moshier formed Trek Aerospace Inc., based in Folsom, California, to develop personal air vehicles using a novel ducted fan design. The company relied on Ames Research Center for a great deal of testing, the results of which have provided greater lift, lowered weight, more power, and improved maneuverability. The technology has been applied to three models: the Dragonfly UMR-1, the Springtail EFV, and the OVIWUN, a small-scale version that is for sale through the company's Web site. It is safer than a manned vehicle, and its size makes it relatively difficult for it to damage itself during test flights the way a larger mass, faster craft could.

  15. Reproductive cloning, genetic engineering and the autonomy of the child: the moral agent and the open future.

    PubMed

    Mameli, M

    2007-02-01

    Some authors have argued that the human use of reproductive cloning and genetic engineering should be prohibited because these biotechnologies would undermine the autonomy of the resulting child. In this paper, two versions of this view are discussed. According to the first version, the autonomy of cloned and genetically engineered people would be undermined because knowledge of the method by which these people have been conceived would make them unable to assume full responsibility for their actions. According to the second version, these biotechnologies would undermine autonomy by violating these people's right to an open future. There is no evidence to show that people conceived through cloning and genetic engineering would inevitably or even in general be unable to assume responsibility for their actions; there is also no evidence for the claim that cloning and genetic engineering would inevitably or even in general rob the child of the possibility to choose from a sufficiently large array of life plans.

  16. Neurodegeneration and Identity.

    PubMed

    Strohminger, Nina; Nichols, Shaun

    2015-09-01

    There is a widespread notion, both within the sciences and among the general public, that mental deterioration can rob individuals of their identity. Yet there have been no systematic investigations of what types of cognitive damage lead people to appear to no longer be themselves. We measured perceived identity change in patients with three kinds of neurodegenerative disease: frontotemporal dementia, Alzheimer's disease, and amyotrophic lateral sclerosis. Structural equation models revealed that injury to the moral faculty plays the primary role in identity discontinuity. Other cognitive deficits, including amnesia, have no measurable impact on identity persistence. Accordingly, frontotemporal dementia has the greatest effect on perceived identity, and amyotrophic lateral sclerosis has the least. We further demonstrated that perceived identity change fully mediates the impact of neurodegenerative disease on relationship deterioration between patient and caregiver. Our results mark a departure from theories that ground personal identity in memory, distinctiveness, dispositional emotion, or global mental function.

  17. Protective Coatings

    NASA Technical Reports Server (NTRS)

    1980-01-01

    General Magnaplate Corporation's pharmaceutical machine is used in the industry for high speed pressing of pills and capsules. Machine is automatic system for molding glycerine suppositories. These machines are typical of many types of drug production and packaging equipment whose metal parts are treated with space spinoff coatings that promote general machine efficiency and contribute to compliance with stringent federal sanitation codes for pharmaceutical manufacture. Collectively known as "synergistic" coatings, these dry lubricants are bonded to a variety of metals to form an extremely hard slippery surface with long lasting self lubrication. The coatings offer multiple advantages; they cannot chip, peel or be rubbed off. They protect machine parts from corrosion and wear longer, lowering maintenance cost and reduce undesired heat caused by power-robbing friction.

  18. Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part III. Surface activity and solubilizing properties of the products of oxyethylation of lard (Adeps suillus, F.P. VIII) in the equilibrium system in relation to lipophilic therapeutic agents (class II and III of BCS).

    PubMed

    Nachajski, Michał J; Piotrowska, Jowita B; Kołodziejczyk, Michał K; Lukosek, Marek; Zgoda, Marian M

    2013-01-01

    Research was conducted into the solubilization processes of diclofenac, ibuprofen, ketoprofen and naproxen in equilibrium conditions in the environment of aqueous solutions of oxyethylated lard's fractions (Adeps suillus, Polish Pharmacopoeia VIII). The determined thermodynamic (cmc, deltaGm(0)) and hydrodynamic (R0, R(obs), omega, M(eta)) parameters characterizing the micelle of the solubilizer and the adduct demonstrate that lipophilic therapeutic agents are adsorbed in a palisade structure of the micelle due to a topologically created so-called "lipophilic adsorption pocket". This shows that the hydrophilicity of the micelle and the adsorption layer decreases at the phase boundary, which is confirmed by the calculated values of coefficients A(m) and r x (a). The results obtained indicate the possibility of making use of the class of non-ionic surfactants which are not ksenobiotics for the modification of the profile of solid oral dosage forms with lipophilic therapeutic agents from the II class of Biopharmaceutics Classification System (BCS).

  19. Effects of dyes and initiators on the holographic data storage properties of photopolymer

    NASA Astrophysics Data System (ADS)

    Gong, Qiaoxia; Wang, Sulian; Huang, Mingju; Dong, Yong; Gan, Fuxi

    2005-09-01

    Effects of dyes and initiators in the photopolymer on the holographic storage properties are studied. Diffraction efficiency of photopolymer with Erythrosin B (ErB) as dye is significantly larger than that the same photopolymer with Eosin Y (EY), Rose Bengal (RsB), Rodamine B (RoB) and Fluorescein (F) as dyes under the same conditions. The maximum absorption of ErB is closer to 514nm than the others, and the photobleaching rate constant of the initiating system is higher than the others. Compared with the holographic properties with triethanolamine(TEA) as initiator, diffraction efficiency of the photopolymer with N-phenylglycine(NPG) as initiator is lower, but the photopolymer shows higher stability.

  20. Pro-Nuclear Environmentalism: Should We Learn to Stop Worrying and Love Nuclear Energy?

    PubMed

    van Munster, Rens; Sylvest, Casper

    2015-10-01

    In light of repeated failures to reach political agreement on effective policies to combat climate change, pro-nuclear environmentalists have set out to reverse the traditionally anti-nuclear inclinations of environmentalists. This essay examines the ideological commitments and assumptions of pro-nuclear environmentalism by performing a critical, historical analysis of the nuclear-environment nexus through the prism of documentary film. We focus on the work and career of documentary filmmaker Rob Stone, whose most recent production, Pandora's Promise (PP) (2013), has emerged as a central statement of this creed. PP actively forges a new political imaginary that replaces the apocalyptic image of nuclear fallout with that of catastrophic climate change. In terms of its rhetorical and visual strategies, however, PP also reveals that pro-nuclear environmentalist arguments have a long lineage. A close study of such continuities reveals a number of political implications that call for reflection as well as caution. PMID:26593709

  1. Engine panel seals for hypersonic engine applications: High temperature leakage assessments and flow modelling

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.; Mutharasan, Rajakkannu; Du, Guang-Wu; Miller, Jeffrey H.; Ko, Frank

    1992-01-01

    A critical mechanical system in advanced hypersonic engines is the panel-edge seal system that seals gaps between the articulating horizontal engine panels and the adjacent engine splitter walls. Significant advancements in seal technology are required to meet the extreme demands placed on the seals, including the simultaneous requirements of low leakage, conformable, high temperature, high pressure, sliding operation. In this investigation, the seal concept design and development of two new seal classes that show promise of meeting these demands will be presented. These seals include the ceramic wafer seal and the braided ceramic rope seal. Presented are key elements of leakage flow models for each of these seal types. Flow models such as these help designers to predict performance-robbing parasitic losses past the seals, and estimate purge coolant flow rates. Comparisons are made between measured and predicted leakage rates over a wide range of engine simulated temperatures and pressures, showing good agreement.

  2. Mechanical defenses of plant extrafloral nectaries against herbivory.

    PubMed

    Gish, Moshe; Mescher, Mark C; De Moraes, Consuelo M

    2016-01-01

    Extrafloral nectaries play an important role in plant defense against herbivores by providing nectar rewards that attract ants and other carnivorous insects. However, extrafloral nectaries can themselves be targets of herbivory, in addition to being exploited by nectar-robbing insects that do not provide defensive services. We recently found that the extrafloral nectaries of Vicia faba plants, as well as immediately adjacent tissues, exhibit high concentrations of chemical toxins, apparently as a defense against herbivory. Here we report that the nectary tissues of this plant also exhibit high levels of structural stiffness compared to surrounding tissues, likely due to cell wall lignification and the concentration of calcium oxalate crystals in nectary tissues, which may provide an additional deterrent to herbivore feeding on nectary tissues. PMID:27489584

  3. The neural antecedents to voluntary action: Response to commentaries

    PubMed Central

    Nachev, Parashkev; Hacker, Peter

    2015-01-01

    Cognitive neuroscience must attend to the conceptual coherence of its hypotheses as well as to their empirical support. Examining the most influential studies of the neural antecedents to voluntary action, our Discussion Paper sought to identify the real-world consequences of neglecting the former in what we argued has been too narrow a pursuit of the latter. Though conceptual in form, our analysis is sharply empirical in its conclusions, revealing what have long been thought to be momentous experimental observations—such as the readiness potential—as the outcome of previously unidentified confounds that rob them of significance. Conversely, we suggested that experimental studies of two-way control, amongst other defining features of the voluntary, have been given less emphasis than the subject demands. Here, we ramify our analysis down the paths identified by others in the commentaries we received. PMID:26001157

  4. Performance of an integrated approach for prediction of bond dissociation enthalpies of phenols extracted from ginger and tea

    NASA Astrophysics Data System (ADS)

    Nam, Pham Cam; Chandra, Asit K.; Nguyen, Minh Tho

    2013-01-01

    Integration of the (RO)B3LYP/6-311++G(2df,2p) with the PM6 method into a two-layer ONIOM is found to produce reasonably accurate BDE(O-H)s of phenolic compounds. The chosen ONIOM model contains only two atoms of the breaking bond as the core zone and is able to provide reliable evaluation for BDE(O-H) for phenols and tocopherol. Deviation of calculated values from experiment is ±(1-2) kcal/mol. BDE(O-H) of several curcuminoids and flavanoids extracted from ginger and tea are computed using the proposed model. The BDE(O-H) values of enol curcumin and epigallocatechin gallate are predicted to be 83.3 ± 2.0 and 76.0 ± 2.0 kcal/mol, respectively.

  5. KSC-04PD-0795

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. -- On a tour of the KSC Space Life Sciences Lab, Florida Gov. Jeb Bush and NASA Administrator Sean OKeefe (at left) listen to Rob Ferl (right), assistant director of the Bio Technology Program, University of Florida (one of the five partners in the SLS Lab). Second from right is U.S. Mint Director Henrietta Holsman Fore. The new lab is a state-of-the- art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The tour followed the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. The ceremony was emceed by Center Director Jim Kennedy and included remarks by OKeefe, Bush, Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

  6. Sterilization and birth control in the shadow of eugenics: married, middle-class women in Alberta, 1930-1960s.

    PubMed

    Dyck, Erika

    2014-01-01

    The history of eugenic sterilization connotes draconian images of coerced and involuntary procedures robbing men and women of their reproductive health. While eugenics programs often fit this characterization, there is another, smaller, and less obvious legacy of eugenics that arguably contributed to a more empowering image of reproductive health. Sexual sterilization surgeries as a form of contraception began to gather momentum alongside eugenics programs in the middle of the 20th century and experiences among prairie women serve as an illustrative example. Alberta maintained its eugenics program from 1929 to 1972 and engaged in thousands of eugenic sterilizations, but by the 1940s middle-class married women pressured their Albertan physicians to provide them with sterilization surgeries to control fertility, as a matter of choice. The multiple meanings and motivations behind this surgery introduced a moral quandary for physicians, which encourages medical historians to revisit the history of eugenics and its relationship to the contemporaneous birth control movement.

  7. [A case of Williams syndrome who exhibited fetishism].

    PubMed

    Noguchi, Masayuki; Kato, Satoshi

    2004-01-01

    Williams syndrome is a rare congenital disease in which the etiological locus is a micro-deletion in chromosome 7. Here, we describe the case of a 22-year-old male who was diagnosed with Williams syndrome at the age of 3 years. As a child, the patient exhibited patterns of behavior characteristic of this syndrome including hyperactivity, attention deficit, and over-friendliness. He also showed persistent interest in construction vehicles, playgrounds, and gloves. He became interested in gloves after watching a television program in which the heroine fought her enemies while wearing gloves. Watching pornographic movies allowed him to attach strong sexual significance to gloves when he was 19 years old. Since that time, he has assaulted women wearing gloves four times to rob them of the gloves. The current paper discusses both the role of the cognitive profile unique to Williams syndrome and that of environmental factors in the development of fetishism in this case. PMID:15669216

  8. Low thermal expansion seal ring support

    DOEpatents

    Dewis, David W.; Glezer, Boris

    2000-01-01

    Today, the trend is to increase the temperature of operation of gas turbine engines. To cool the components with compressor discharge air, robs air which could otherwise be used for combustion and creates a less efficient gas turbine engine. The present low thermal expansion sealing ring support system reduces the quantity of cooling air required while maintaining life and longevity of the components. Additionally, the low thermal expansion sealing ring reduces the clearance "C","C'" demanded between the interface between the sealing surface and the tip of the plurality of turbine blades. The sealing ring is supported by a plurality of support members in a manner in which the sealing ring and the plurality of support members independently expand and contract relative to each other and to other gas turbine engine components.

  9. Is neural Darwinism Darwinism?

    PubMed

    van Belle, T

    1997-01-01

    Neural Darwinism is a theory of cognition developed by Gerald Edelman along with George Reeke and Olaf Sporns at Rockefeller University. As its name suggests, neural Darwinism is modeled after biological Darwinism, and its authors assert that the two processes are strongly analogous. both operate on variation in a population, amplifying the more adaptive individuals. However, from a computational perspective, neural Darwinism is quite different from other models of natural selection, such as genetic algorithms. The individuals of neural Darwinism do not replicate, thus robbing the process of the capacity to explore new solutions over time and ultimately reducing it to a random search. Because neural Darwinism does not have the computational power of a truly Darwinian process, it is misleading to label it as such. to illustrate this disparity in adaptive power, one of Edelman's early computer experiments, Darwin I, is revisited, and it is shown that adding replication greatly improves the adaptive power of the system.

  10. Medical humanities and philosophy: is the universe expanding or contracting?

    PubMed

    Stempsey, William E

    2007-12-01

    The question of whether the universe is expanding or contracting serves as a model for current questions facing the medical humanities. The medical humanities might aptly be described as a metamedical multiverse encompassing many separate universes of discourse, the most prominent of which is probably bioethics. Bioethics, however, is increasingly developing into a new interdisciplinary discipline, and threatens to engulf the other medical humanities, robbing them of their own distinctive contributions to metamedicine. The philosophy of medicine considered as a distinct field of study has suffered as a result. Indeed, consensus on whether the philosophy of medicine even constitutes a legitimate field of study is lacking. This paper presents an argument for the importance of a broad conception of the philosophy of medicine and the central role it should play in organizing and interpreting the various fields of study that make up the metamedical multiverse. PMID:17549604

  11. The neural antecedents to voluntary action: Response to commentaries.

    PubMed

    Nachev, Parashkev; Hacker, Peter

    2015-01-01

    Cognitive neuroscience must attend to the conceptual coherence of its hypotheses as well as to their empirical support. Examining the most influential studies of the neural antecedents to voluntary action, our Discussion Paper sought to identify the real-world consequences of neglecting the former in what we argued has been too narrow a pursuit of the latter. Though conceptual in form, our analysis is sharply empirical in its conclusions, revealing what have long been thought to be momentous experimental observations--such as the readiness potential--as the outcome of previously unidentified confounds that rob them of significance. Conversely, we suggested that experimental studies of two-way control, amongst other defining features of the voluntary, have been given less emphasis than the subject demands. Here, we ramify our analysis down the paths identified by others in the commentaries we received.

  12. Advanced multi-GNSS troposphere modeling for improved monitoring and forecasting of severe weather

    NASA Astrophysics Data System (ADS)

    Pottiaux, Eric; Berckmans, Julie; Bruyninx, Carine

    2014-05-01

    The Royal Observatory of Belgium (ROB) contributes to the EUMETNET EIG GNSS Water Vapour Program (E-GVAP) aiming at the operational exploitation of GNSS signals for improving Numerical Weather Prediction (NWP). Within E-GVAP, ROB provides hourly-updated Zenith Tropospheric Delays (ZTDs) from a network of about 350 GPS stations covering Europe. Over the past years, many GPS station operators have upgraded their equipment to observe simultaneously multiple GNSS (GPS, GLONASS, Galileo). However, these additional observations are presently not exploited for operational meteorology, which still relies on the analysis of GPS-only observations to provide only ZTD (no or few information on spatial heterogeneities is provided). Improving this situation is one of the goals of the new COST Action ES1206: "Advanced GNSS Tropospheric Products for Monitoring Extreme Weather Events and Climate" (GNSS4SWEC) to which ROB participates. In that context, ROB is investigating a new processing strategy using the latest Bernese software version 5.2 to provide new and enhanced tropospheric products, including the estimation of ZTD and horizontal gradients, based on the analysis of multi-GNSS observations. These products will improve the analysis of the behavior of atmospheric water vapor (including its local heterogeneities) and stimulate the use of GNSS for the monitoring and forecasting of severe weather. As a first step, we studied the benefits of including GLONASS observations w.r.t. a GPS-only processing system, focusing particularly on the reliability and stability of the ZTD estimation. We also studied the sensitivity of the new multi-GNSS ZTD estimates with respect to the relative constraints imposed during the parameter estimation. In our setup, relative constraints of 0.007m provide a good balance between reducing the noise and allowing for the natural variability of the ZTD. We also show that the new multi-GNSS ZTD estimates generally agree with the GPS-only estimates at the

  13. Patient's jewelry stolen as she rests in the ED.

    PubMed

    2007-12-01

    In a hospital ED in Rhode Island, a 96-year-old patient was robbed of her jewelry while she rested in her room. The thief was dressed in scrubs. Identification badges are only one way of keeping unwanted intruders out and your patients' belongings safe. Other suggestions: Have different groups of staff members, i.e., ED doctors and nurses, wear color-coded scrubs that distinguish them from other hospital personnel. If your staff see a strangely dressed person or someone who looks lost or like they don't fit in, they should question them about their identity. Create protocols for the removal and safekeeping of patients' jewelry that cover several different scenarios.

  14. Measuring the Impact of Programs that Challenge the Public Stigma of Mental Illness

    PubMed Central

    Corrigan, Patrick W.; Shapiro, Jenessa R.

    2010-01-01

    Public stigma robs people with mental illnesses from rightful opportunities related to work and other important life goals. Advocates have developed anti-stigma programs meant to address the prejudice and discrimination associated with these conditions. Evidence is now needed to make sense of program impact; this paper looks at measurement issues related to stigma change. Community based participatory research is central to this research and includes the involvement of a diverse collection of stakeholders in all phases of evaluation. Investigators should be cautious about measures vis-à-vis social desirability effects and should directed by social validity of targeted audiences. Conceptual domains with some research support that correspond with assessments include behavior, penetration, psychological perspective, knowledge, and physiological/information processes. These issues are summarized as ten recommendations for evaluation of anti-stigma programs. PMID:20674114

  15. Web site blues.

    PubMed

    Maruca, R F

    1999-01-01

    So far, Rachel Soltanoff's instincts had been right. As CEO in this fictional case study, she had successfully navigated TradeRite Software's transition from a news service for stockbrokers to a $70 million provider of shrink-wrapped software geared toward both brokers and the growing day-trader market. Now a well-financed start-up, Stock-net.com, was testing a very competitive product that traders could download directly over the Web. And TradeRite's Web site was nothing more than a collection of elaborate marketing brochures. Rachel knew she needed to start selling over the Web. But the e-commerce consultants she had hired to set up her Web store were behind schedule, and their 21-year-old CEO had just resigned. Her product manager, Lisa Bandini, was working overtime to transform TradeRite's entire product line into Web-aware applications to match Stocknet's, and Rachel had $2.5 million to launch them. But the consultants said it would take $5 million just to rent e-commerce capabilities. Ace sales VP Brian Rockart thought the company had already wasted too much time and money--money from his budget--on its Web site. Marketing VP Rob Collins thought TradeRite should focus on its core stockbroker customers. Chief Technical Officer Joe Martinez doesn't want to go ahead without a pilot project. Should Rachel try to convince Brian, Rob, and the rest of the senior management team that e-commerce is the way to go? Four commentators offer advice. PMID:10387770

  16. The 2012 Transit of Venus for Cytherean Atmospheric Studies and as an Exoplanet Analog

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Schneider, G.; Babcock, B. A.; Lu, M.; Reardon, K. P.; Widemann, T.; Tanga, P.; Dantowitz, R.; Willson, R.; Kopp, G.; Yurchyshyn, V.; Sterling, A.; Scherrer, P.; Schou, J.; Golub, L.; Reeves, K.

    2012-10-01

    We worked to assemble as complete a dataset as possible for the Cytherean atmosphere in collaboration with Venus Express in situ and to provide an analog of spectral and total irradiance exoplanet measurements. From Haleakala, the whole transit was visible in coronal skies; our B images showed the evolution of the visibility of Venus's atmosphere and of the black-drop effect, as part of the Venus Twilight Experiment's 9 coronagraphs distributed worldwide with BVRI. We imaged the Cytherean atmosphere over two minutes before first contact, with subarcsecond resolution, with the coronagraph and a separate refractor. The IBIS imaging spectrometer at Sacramento Peak Observatory at H-alpha and carbon-dioxide also provided us high-resolution imaging. The NST of Big Bear Solar Observatory also provided high-resolution vacuum observations of the Cytherean atmosphere and black drop evolution. Our liaison with UH's Mees Solar Observatory scientists provided magneto-optical imaging at calcium and potassium. Spaceborne observations included the Solar Dynamics Observatory's AIA and HMI, and the Solar Optical Telescope (SOT) and X-ray Telescope (XRT) on Hinode, and total-solar-irradiance measurements with ACRIMSAT and SORCE/TIM, to characterize the event as an exoplanet-transit analog. Our expedition was sponsored by the Committee for Research and Exploration/National Geographic Society. Some of the funds for the carbon-dioxide filter for IBIS were provided by NASA through AAS's Small Research Grant Program. We thank Rob Lucas, Aram Friedman, and Eric Pilger '82 for assistance with Haleakala observing, Rob Ratkowski of Haleakala Amateur Astronomers for assistance with equipment and with the site, Stan Truitt for the loan of his Paramount ME, and Steve Bisque/Software Bisque for TheSky X controller. We thank Joseph Gangestad '06 of Aerospace Corp., a veteran of our 2004 expedition, for assistance at Big Bear. We thank the Lockheed Martin Solar and Astrophysics Laboratory and

  17. Effectiveness and safety of treatments used for the management of patent ductus arteriosus (PDA) in preterm infants: a protocol for a systematic review and network meta-analysis

    PubMed Central

    Mitra, Souvik; Tamayo, Maria E; Aune, Dagfinn; Mbuagbaw, Lawrence; Veroniki, Areti-Angeliki; Thabane, Lehana

    2016-01-01

    Introduction Management of patent ductus arteriosus (PDA) in preterm infants is one of the most controversial topics in neonatal medicine. The availability of different pharmacotherapeutic options often poses a practical challenge to the practising neonatologist as to which one to choose as a therapeutic option. Our objectives are to determine the relative merits of the available pharmacotherapeutic options for the management of PDA. Methods and Analysis We will conduct a systematic review of all randomised controlled trials evaluating the use of intravenous or oral: indomethacin, ibuprofen and acetaminophen for the treatment of PDA in preterm infants. The primary outcome is failure of closure of the PDA. Secondary outcomes are neonatal mortality, need for surgical closure, duration of ventilator support, chronic lung disease, intraventricular haemorrhage, periventricular leukomalacia, necrotising enterocolitis, gastrointestinal bleeding, time to full enteral feeds and oliguria. We will search Medline, Embase and Cochrane Central Register of Controlled Trials (CENTRAL) as well as grey literature resources. Two reviewers will independently screen titles and abstracts, review full texts, extract information, and assess the risk of bias (ROB) and the confidence in the estimate (with Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach). Subgroup analysis according to gestational age, birth weight, different doses of interventions, time of administration of the first dose of the intervention, and echocardiographic definition of haemodynamically significant PDA and ROB are planned. We will perform a Bayesian network meta-analysis to combine the pooled direct and indirect treatment effect estimates for each outcome, if adequate data are available. Ethics and Dissemination The results will help to reduce the uncertainty about the safety and effectiveness of the interventions, will identify knowledge gaps or will encourage further research for

  18. Systematic review of acupuncture to control hot flashes in cancer patients.

    PubMed

    Garcia, M Kay; Graham-Getty, Leslie; Haddad, Robin; Li, Yisheng; McQuade, Jennifer; Lee, Richard T; Spano, Michael; Cohen, Lorenzo

    2015-11-15

    Hot flashes (HFs) are a common side effect of cancer treatment. The purpose of this systematic review was to evaluate evidence related to the use of acupuncture for HFs in cancer patients. EMBASE, MEDLINE, Cochrane (all databases), PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched from their inception through December 2014. Included studies had to be randomized controlled trials with a usual-care and/or placebo comparison group that investigated acupuncture to treat HFs in cancer patients. No language limits were applied. The risk of bias (ROB) was rated as low, high, or unclear according to Cochrane criteria. Both within-group and between-group changes were evaluated. Four hundred two items were identified, and 192 duplicates were omitted; this left 210 publications to be screened. Eight studies met the inclusion criteria, and all involved women with breast cancer. All studies showed significant within-group improvement from the baseline for true acupuncture (TA). One study showed significant improvement in favor of TA over sham acupuncture (SA; P < .001), 1 study found in favor of TA over SA for nighttime HFs only (P = .03), and 1 study found in favor of TA over SA or untreated controls (P < .01 and P < .001, respectively). Between-group (TA vs SA) effect size (ES) estimates for daytime and nighttime HFs were calculated (ES range, 0.04-0.9) whenever possible. No studies were rated with a low ROB. In conclusion, the current level of evidence is insufficient to either support or refute the benefits of acupuncture for the management of HFs in cancer patients. Future studies should provide within-group and between-group ES estimates in addition to P values.

  19. The Near-Earth Asteroid Rendezvous (NEAR) Mission, the Mars Surveyor 2001 (MS01) Mission, and the Planetary Instrument Definition and Development Program (PIDDP)

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The NEAR Mission was launched on February 17, 1996 for a three year cruise to the asteroid 433 Eros. During October, November, and December 1998 cruise measurements with the gamma-ray spectrometer were made at three different escape-window-width settings. These were done in order to understand how the count rate and peak width change as the window width settings change. Analysis of these spectra was completed using the latest version of the spectral analysis program, RobWin. Results as a function of energy were combined with the results from the Schlumberger-Doll Research experiments (described below). Laboratory measurements were needed to confirm efficiency calculations above 6 MeV and to understand the relationship between the full energy peak areas and the areas of the first and second escape peaks as a function of the escape peak widths. A week of measurements was made at Schlumberger-Doll Research using their 14-MeV pulsed neutron generator and large soil samples. Data were collected after adding iron and nickel to the sample to increase the emission of high-energy lines. Approximately 24 hours of data were accumulated at each of three escape peak window widths. These data were analyzed with RobWin. Combining results from the cruise measurements and the laboratory measurements indicated that both data sets had similar energy dependence and that this energy dependence was different from that obtained using standard Monte Carlo calculations. Alternate methods of simulating the response of the detector to changes in the escape window widths are being investigated.

  20. Characterization of RarA, a Novel AraC Family Multidrug Resistance Regulator in Klebsiella pneumoniae

    PubMed Central

    Veleba, Mark; Higgins, Paul G.; Gonzalez, Gerardo; Seifert, Harald

    2012-01-01

    Transcriptional regulators, such as SoxS, RamA, MarA, and Rob, which upregulate the AcrAB efflux pump, have been shown to be associated with multidrug resistance in clinically relevant Gram-negative bacteria. In addition to the multidrug resistance phenotype, these regulators have also been shown to play a role in the cellular metabolism and possibly the virulence potential of microbial cells. As such, the increased expression of these proteins is likely to cause pleiotropic phenotypes. Klebsiella pneumoniae is a major nosocomial pathogen which can express the SoxS, MarA, Rob, and RamA proteins, and the accompanying paper shows that the increased transcription of ramA is associated with tigecycline resistance (M. Veleba and T. Schneiders, Antimicrob. Agents Chemother. 56:4466–4467, 2012). Bioinformatic analyses of the available Klebsiella genome sequences show that an additional AraC-type regulator is encoded chromosomally. In this work, we characterize this novel AraC-type regulator, hereby called RarA (Regulator of antibiotic resistance A), which is encoded in K. pneumoniae, Enterobacter sp. 638, Serratia proteamaculans 568, and Enterobacter cloacae. We show that the overexpression of rarA results in a multidrug resistance phenotype which requires a functional AcrAB efflux pump but is independent of the other AraC regulators. Quantitative real-time PCR experiments show that rarA (MGH 78578 KPN_02968) and its neighboring efflux pump operon oqxAB (KPN_02969_02970) are consistently upregulated in clinical isolates collected from various geographical locations (Chile, Turkey, and Germany). Our results suggest that rarA overexpression upregulates the oqxAB efflux pump. Additionally, it appears that oqxR, encoding a GntR-type regulator adjacent to the oqxAB operon, is able to downregulate the expression of the oqxAB efflux pump, where OqxR complementation resulted in reductions to olaquindox MICs. PMID:22644028

  1. Model of transcriptional activation by MarA in escherichia coli

    SciTech Connect

    Wall, Michael E; Rosner, Judah L; Martin, Robert G

    2009-01-01

    The AraC family transcription factor MarA activates approximately 40 genes (the marA/soxS/rob regulon) of the Escherichia coli chromosome resulting in different levels of resistance to a wide array of antibiotics and to superoxides. Activation of marA/soxS/rob regulon promoters occurs in a well-defined order with respect to the level of MarA; however, the order of activation does not parallel the strength of MarA binding to promoter sequences. To understand this lack of correspondence, we developed a computational model of transcriptional activation in which a transcription factor either increases or decreases RNA polymerase binding, and either accelerates or retards post-binding events associated with transcription initiation. We used the model to analyze data characterizing MarA regulation of promoter activity. The model clearly explains the lack of correspondence between the order of activation and the MarA-DNA affinity and indicates that the order of activation can only be predicted using information about the strength of the full MarA-polymerase-DNA interaction. The analysis further suggests that MarA can activate without increasing polymerase binding and that activation can even involve a decrease in polymerase binding, which is opposite to the textbook model of activation by recruitment. These findings are consistent with published chromatin immunoprecipitation assays of interactions between polymerase and the E. coli chromosome. We find that activation involving decreased polymerase binding yields lower latency in gene regulation and therefore might confer a competitive advantage to cells. Our model yields insights into requirements for predicting the order of activation of a regulon and enables us to suggest that activation might involve a decrease in polymerase binding which we expect to be an important theme of gene regulation in E. coli and beyond.

  2. Membrane Stresses Induced by Overproduction of Free Fatty Acids in Escherichia coli▿†

    PubMed Central

    Lennen, Rebecca M.; Kruziki, Max A.; Kumar, Kritika; Zinkel, Robert A.; Burnum, Kristin E.; Lipton, Mary S.; Hoover, Spencer W.; Ranatunga, Don R.; Wittkopp, Tyler M.; Marner, Wesley D.; Pfleger, Brian F.

    2011-01-01

    Microbially produced fatty acids are potential precursors to high-energy-density biofuels, including alkanes and alkyl ethyl esters, by either catalytic conversion of free fatty acids (FFAs) or enzymatic conversion of acyl-acyl carrier protein or acyl-coenzyme A intermediates. Metabolic engineering efforts aimed at overproducing FFAs in Escherichia coli have achieved less than 30% of the maximum theoretical yield on the supplied carbon source. In this work, the viability, morphology, transcript levels, and protein levels of a strain of E. coli that overproduces medium-chain-length FFAs was compared to an engineered control strain. By early stationary phase, an 85% reduction in viable cell counts and exacerbated loss of inner membrane integrity were observed in the FFA-overproducing strain. These effects were enhanced in strains endogenously producing FFAs compared to strains exposed to exogenously fed FFAs. Under two sets of cultivation conditions, long-chain unsaturated fatty acid content greatly increased, and the expression of genes and proteins required for unsaturated fatty acid biosynthesis were significantly decreased. Membrane stresses were further implicated by increased expression of genes and proteins of the phage shock response, the MarA/Rob/SoxS regulon, and the nuo and cyo operons of aerobic respiration. Gene deletion studies confirmed the importance of the phage shock proteins and Rob for maintaining cell viability; however, little to no change in FFA titer was observed after 24 h of cultivation. The results of this study serve as a baseline for future targeted attempts to improve FFA yields and titers in E. coli. PMID:21948837

  3. Avoidance behaviour of two eco-physiologically different earthworms (Eisenia fetida and Aporrectodea caliginosa) in natural and artificial saline soils.

    PubMed

    Owojori, O J; Reinecke, A J

    2009-04-01

    We studied the avoidance behaviour of Eisenia fetida and Aporrectodea caliginosa in OECD artificial soil spiked with NaCl and in natural saline soil (of varying ionic constitutions) collected from Robertson Experimental Farm (ROBS) in Western Cape, South Africa. For each organism, the ecotoxicological test was performed using a two-chamber test over a period of 48 h. The results showed that in the OECD soil, the avoidance EC50 (the concentration/electrical conductivity at which there is effect on 50% of the organisms) for A. caliginosa of 667 mg kg(-1) NaCl was lower than 1164 mg kg(-1) for E. fetida. Similarly in ROBS soil, the avoidance EC50 for A. caliginosa of 0.26 dS m(-1) was lower than 0.56 dS m(-1) in E. fetida. These results indicated that A. caliginosa showed better avoidance to salinity than E. fetida irrespective of soil types or ionic constitution. When compared with literature data, EC50 values in avoidance tests were either lower or comparable to those of reproduction, which was the most sensitive life-cycle parameter. The only exception was the EC50 value for avoidance of E. fetida in natural soil which was higher than for reproduction suggesting that the predictive value of the avoidance test for this species might be lower in natural soils. The variation in sensitivities of these earthworms could be as a result of differences in their eco-physiology. These findings suggest the relevance of the avoidance test as a suitable screening method showing first tendencies of saline stress on the habitat function of soils. PMID:19211128

  4. Determining Acceptable Explosive Charge Mass Under Different Geological Conditions / Problematyka Wyznaczania Dopuszczalnych Ładunków Mw W Zróżnicowanych Warunkach Geologicznych

    NASA Astrophysics Data System (ADS)

    Pyra, Józef; Sołtys, Anna; Winzer, Jan; Dworzak, Michał; Biessikirski, Andrzej

    2015-09-01

    This article presents a procedure for determining the safety of explosive charges for their surrounding environment, using a limestone mine as a case study. Varied geological structures, as well as other constructions in the surrounding area of a mine, sometimes necessitate the use of two or more ground vibration propagation equations, and thus a variety of explosive charges, depending on the area of rock blasting. This is a crucial issue for the contractor, as it is important to blast the rock as few times as possible, while using the maximum amount of explosive charge for each blast. Wykonywanie robót strzałowych w górnictwie polega na odpalaniu mas materiału wybuchowego (MW) celem uzyskania dużej ilości odpowiednio rozdrobnionego urobku. W momencie zwiększonego popytu na surowce skalne zakłady górnicze zmuszone są do zwielokrotnienia wykonywania prac strzałowych aby zapewnić regularne dostawy produktu. Konsekwencją takich działań jest ponoszenie dodatkowych kosztów operacyjnych. Celem ich minimalizacji oraz uzyskania jak największej efektywności prowadzonych robót strzałowych jest wydłużanie serii, a więc stosowanie coraz to większych mas ładunków materiałów wybuchowych. Efektem takiego postępowanie jest możliwość wystąpienia w otoczeniu oddziaływania o potencjalnie szkodliwym charakterze m. in. drgania parasejsmiczne. Aby wyeliminować powyższy problem oraz zapewnić niezbędny komfort mieszkańcom, Prawo geologiczne i górnicze, Prawo ochrony środowiska i rozporządzenia wykonawcze nakładają na podmiot wykonujący roboty strzałowe obowiązek ochrony otoczenia, poprzez prowadzenie działalności profilaktycznej w zakresie kontroli, monitorowania oraz wyznaczania dopuszczalnych mas ładunków MW. W momencie gdy nie ma możliwości ograniczenia niepożądanych wpływów dynamicznych po przez zmianę parametrów siatki strzałowej czy modyfikację struktury czasowo-częstotliwościowej drgań, jedyną możliwością staje si

  5. Impact of Bisphosphonate on Orthodontic tooth movement and osteoclastic count: An Animal Study

    PubMed Central

    Venkataramana, V; Chidambaram, S; Reddy, B Vishnuvardhan; Goud, E V Soma Shekara; Arafath, Mohammed; Krishnan, Santhana

    2014-01-01

    Background : The aim of the current study is to examine the effect of systemically administered BP-Pamidronate, on Orthodontic Tooth Movement (OTM) along with osteoclastic quantification in New Zealand white rabbits. Materials & Methods : Twenty rabbits used in the study, were equally divided into 2 groups ; Group-1 as Control & Group-2 as Experimental. A sentalloy NITI closed coil spring (GAC International, USA) of 100 gram force, ligated between the lower first molar and the anterior most incisors of the rabbit has served as orthodontic force element. The BP- Pamidronate was administered at the dosage of 1.5 mg/kg body intra-peritonially, on the 1st, 7th and 14th day of the experiment. On the 21st day both group of animals were sacrificed, mandibles were dissected. The formed diastema between the 1st and 2nd molar was measured on the dissected mandibles using standard metric scale, which is considered as the OTM in the mesial direction. Next, the alveolar bone regions along with intact mesial surfaces were processed for histological investigation (osteoclastic count). Results : The student ‘t’ test has been done to compare the mean values of molar tooth movement and osteoclastic count. Parameter :1 molar tooth movement has shown a significant difference between the control (3.750 ± 0.548 mm) and the experimental group (3.050 ± 0.556 mm) with calculated ‘p’ value (p-value <0.05) is significant at 0.0110 level. Parameter : 2 osteoclastic count has shown a significant difference between the control (13.335000 ± 0.735856 per square mm.) and the experimental group (11.426900 ± 1.49369 per square mm) calculated ‘p’ value (p-value <0.05) is significant at 0.003 level. Conclusion : The molar tooth movement and the osteoclastic count were significantly reduced in BP – Pamidronate administered animals than non-drug recipients. How to cite the article: Venkataramana V, Chidambaram S, Reddy BV, Goud EV, Arafath M, Krishnan S. Impact of Bisphosphonate on

  6. F3D Image Processing and Analysis for Many - and Multi-core Platforms

    2014-10-01

    F3D is written in OpenCL, so it achieve[sic] platform-portable parallelism on modern mutli-core CPUs and many-core GPUs. The interface and mechanims to access F3D core are written in Java as a plugin for Fiji/ImageJ to deliver several key image-processing algorithms necessary to remove artifacts from micro-tomography data. The algorithms consist of data parallel aware filters that can efficiently utilizes[sic] resources and can work on out of core datasets and scale efficiently across multiple accelerators. Optimizingmore » for data parallel filters, streaming out of core datasets, and efficient resource and memory and data managements over complex execution sequence of filters greatly expedites any scientific workflow with image processing requirements. F3D performs several different types of 3D image processing operations, such as non-linear filtering using bilateral filtering and/or median filtering and/or morphological operators (MM). F3D gray-level MM operators are one-pass constant time methods that can perform morphological transformations with a line-structuring element oriented in discrete directions. Additionally, MM operators can be applied to gray-scale images, and consist of two parts: (a) a reference shape or structuring element, which is translated over the image, and (b) a mechanism, or operation, that defines the comparisons to be performed between the image and the structuring element. This tool provides a critical component within many complex pipelines such as those for performing automated segmentation of image stacks. F3D is also called a "descendent" of Quant-CT, another software we developed in the past. These two modules are to be integrated in a next version. Further details were reported in: D.M. Ushizima, T. Perciano, H. Krishnan, B. Loring, H. Bale, D. Parkinson, and J. Sethian. Structure recognition from high-resolution images of ceramic composites. IEEE International Conference on Big Data, October 2014.« less

  7. A preliminary investigation of Large Eddy Simulation (LES) of the flow around a cylinder at ReD = 3900 using a commercial CFD code

    SciTech Connect

    Paschkewitz, J S

    2006-02-14

    Engineering fluid mechanics simulations at high Reynolds numbers have traditionally been performed using the Reynolds-Averaged Navier Stokes (RANS) equations and a turbulence model. The RANS methodology has well-documented shortcomings in the modeling of separated or bluff body wake flows that are characterized by unsteady vortex shedding. The resulting turbulence statistics are strongly influenced by the detailed structure and dynamics of the large eddies, which are poorly captured using RANS models (Rodi 1997; Krishnan et al. 2004). The Large Eddy Simulation (LES) methodology offers the potential to more accurately simulate these flows as it resolves the large-scale unsteady motions and entails modeling of only the smallest-scale turbulence structures. Commercial computational fluid dynamics products are beginning to offer LES capability, allowing practicing engineers an opportunity to apply this turbulence modeling technique to much wider array of problems than in dedicated research codes. Here, we present a preliminary evaluation of the LES capability in the commercial CFD solver StarCD by simulating the flow around a cylinder at a Reynolds number based on the cylinder diameter, D, of 3900 using the constant coefficient Smagorinsky LES model. The results are compared to both the experimental and computational results provided in Kravchenko & Moin (2000). We find that StarCD provides predictions of lift and drag coefficients that are within 15% of the experimental values. Reasonable agreement is obtained between the time-averaged velocity statistics and the published data. The differences in these metrics may be due to the use of a truncated domain in the spanwise direction and the short time-averaging period used for the statistics presented here. The instantaneous flow field visualizations show a coarser, larger-scale structure than the study of Kravchenko & Moin (2000), which may be a product of the LES implementation or of the domain and resolution used

  8. Spectroscopy as a diagnostic tool for urban soil contaminants

    NASA Astrophysics Data System (ADS)

    Brook, Anna; Kopel, Daniella

    2014-05-01

    Urbanization has become one of the major forces of change around the globe. Land use transformation, especially urbanization has the most profound influences of human activities because it affects so many of the planet's physical and biological systems. Land use changes directly impact the ability of the earth to continue to provide ecological services to human society and the other occupants of the ecosystems. The urban process gradually degrades and transforms agricultural and natural ecosystems into built environments. The urban environment includes cities, suburbs, peri-urban areas and towns. Urban ecosystems are highly heterogeneous due to the variety of land covers and land purposes. Thus, the choices on managing the extent and arranging the land cover patches (e.g., lawns) assist to shape the emergent structure and function of the urban ecosystems. As a result of ecological conditions and current management status the urban soils show substantial spatial heterogeneity. Whereas, adverse effects of pollutants on ecosystems have been demonstrated, one important need for environmental impact assessment have been defined as maintenance of long-term monitoring systems, which can enable to improve monitoring, modelling and assessment of various stressors in agriculture environment. Diffuse reflectance spectroscopy and diffuse reflectance Fourier-transform infrared (FTIR) spectroscopy across visible-near- short- mid- and long- wave infrared (0.4-14μm) has the potential to meet this demand. Relationships between spectral reflectance and soil properties, such as grain size distribution, moisture, iron oxides, carbonate content, and organic matter, have already been established in many studies (Krishnan et al. 1980, Ben-Dor and Banin 1995, Jarmer et al. 2008, Richter et al. 2009). The aims of this study are to develop diagnostic tool for heavy metals, polycyclic aromatic hydrocarbons, asbestos and other anthropogenic contaminants in urban soil using spectroscopy

  9. PREFACE: Acceleration and radiation generation in space and laboratory plasmas

    NASA Astrophysics Data System (ADS)

    Bingham, R.; Katsouleas, T.; Dawson, J. M.; Stenflo, L.

    1994-01-01

    and radiation generation in plasmas. The next section includes state-of-the-art papers on laboratory accelerators driven by lasers (Nakajima et al., Shukla, Johnson et al.), microwaves (Nishida et al., Bogomolov et al.) and by particle beams (Ogata et al.). Also in this section are theoretical papers presenting new work on synchrotron like oscillations in plasma waves (Fedele) and two types of laboratory radiation sources, FEL's (Marshall et al.) and ionization fronts (Lai et al.), and Frantzeskakis et al. described the Hamiltonian analysis of a slow-wave autonomous cyclotron buncher. Section 3 contains papers on astrophysical plasmas, with the general presentations of Colgate and Krishnan. Kazanas and Krishnan address active galactic nuclei (AGNs). Thielheim discusses general acceleration mech anisms in rotating magnetized systems. Asseo discussed Langmuir solitons in pulsars and Blackman et al. treat magnetic reconnection relativistically. Su et al. analyze the possibility of plasma wave excitation and particle acceleration by neu trinos from supernovae. Dogiel et al. on cosmic ray scattering by MHD fluctuations. The papers in Section 4 treat fusion plasmas (Dendy et al. and Lashmore-Davies et al.). Section 5, space plasmas, includes papers on acceleration processes in the magnetosphere (Anagnostopoulos and Marshall et al.) and the sun (Barletta et al.). It is evident from the Workshop and the papers collected here that this is indeed a rich field of investigations and that both the natural and laboratory plasma communities can benefit from the cross-fertilization of ideas between them. We wish to thank the authors and attendees for their contributions to the success of this workshop, Dr Philip Debenham and Dr David Sutter of the U.S. D.o.E. and Dr Charles Roberson of the U.S. O.N.R. for their financial support (Grants DE-FGO3-93ER40776 and N00014-93-1-0814), and the ECC Twinning Grant SC1*-CT92-0773. We appreciate the considerable local support from Mr Glegles and

  10. Modeling organic aerosols in a megacity: Potential contribution of semi-volatile and intermediate volatility primary organic compounds to secondary organic aerosol formation

    SciTech Connect

    Hodzic, A.; Kleinman, L.; Jimenez, J. L.; Madronich, S.; Canagaratna, M. R.; DeCarlo, P. F.; Fast, J.

    2010-06-01

    It has been established that observed local and regional levels of secondary organic aerosols (SOA) in polluted areas cannot be explained by the oxidation and partitioning of anthropogenic and biogenic VOC precursors, at least using current mechanisms and parameterizations. In this study, the 3-D regional air quality model CHIMERE is applied to estimate the potential contribution to SOA formation of recently identified semi-volatile and intermediate volatility organic precursors (S/IVOC) in and around Mexico City for the MILAGRO field experiment during March 2006. The model has been updated to include explicitly the volatility distribution of primary organic aerosols (POA), their gas-particle partitioning and the gas-phase oxidation of the vapors. Two recently proposed parameterizations, those of Robinson et al. (2007) ('ROB') and Grieshop et al. (2009) ('GRI') are compared and evaluated against surface and aircraft measurements. The 3-D model results are assessed by comparing with the concentrations of OA components from Positive Matrix Factorization of Aerosol Mass Spectrometer (AMS) data, and for the first time also with oxygen-to-carbon ratios derived from high-resolution AMS measurements. The results show a substantial enhancement in predicted SOA concentrations (2-4 times) with respect to the previously published base case without S/IVOCs (Hodzic et al., 2009), both within and downwind of the city leading to much reduced discrepancies with the total OA measurements. Model improvements in OA predictions are associated with the better-captured SOA magnitude and diurnal variability. The predicted production from anthropogenic and biomass burning S/IVOC represents 40-60% of the total measured SOA at the surface during the day and is somewhat larger than that from commonly measured aromatic VOCs, especially at the T1 site at the edge of the city. The SOA production from the continued multi-generation S/IVOC oxidation products continues actively downwind. Similar

  11. The Effectiveness of Conservative Management for Acute Whiplash Associated Disorder (WAD) II: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

    PubMed Central

    Wiangkham, Taweewat; Duda, Joan; Haque, Sayeed; Madi, Mohammad; Rushton, Alison

    2015-01-01

    Objective To evaluate the effectiveness of conservative management (except drug therapy) for acute Whiplash Associated Disorder (WAD) II. Design Systematic review and meta-analysis of Randomised Controlled Trials (RCTs) using a pre-defined protocol. Two independent reviewers searched information sources, decided eligibility of studies, and assessed risk of bias (RoB) of included trials. Data were extracted by one reviewer and checked by the other. A third reviewer mediated any disagreements throughout. Qualitative trial and RoB data were summarised descriptively. Quantitative syntheses were conducted across trials for comparable interventions, outcome measures and assessment points. Meta-analyses compared effect sizes with random effects, using STATA version 12. Data Sources PEDro, Medline, Embase, AMED, CINAHL, PsycINFO, and Cochrane Library with manual searching in key journals, reference lists, British National Bibliography for Report Literature, Center for International Rehabilitation Research Information & Exchange, and National Technical Information Service were searched from inception to 15th April 2015. Active researchers in the field were contacted to determine relevant studies. Eligibility Criteria for Selecting Studies RCTs evaluating acute (<4 weeks) WADII, any conservative intervention, with outcome measures important to the International Classification of Function, Disability and Health. Results Fifteen RCTs all assessed as high RoB (n=1676 participants) across 9 countries were included. Meta-analyses enabled 4 intervention comparisons: conservative versus standard/control, active versus passive, behavioural versus standard/control, and early versus late. Conservative intervention was more effective for pain reduction at 6 months (95%CI: -20.14 to -3.38) and 1-3 years (-25.44 to -3.19), and improvement in cervical mobility in the horizontal plane at <3 months (0.43 to 5.60) compared with standard/control intervention. Active intervention was effective

  12. Theoretical determination of the standard reduction potentials of pheophytin-a in N,N-dimethyl formamide and membrane.

    PubMed

    Mehta, Nital; Datta, Sambhu N

    2007-06-28

    Quantum mechanical/molecular mechanics (QM/MM) calculations were performed on the neutral, anionic, and dianionic forms of Pheophytin-a (Pheo-a) in N,N-dimethyl formamide (DMF) in order to calculate the absolute free energy of reduction of Pheo-a in solution. The geometry of the solvated species was optimized by restricted open-shell density functional treatment (ROB3LYP) using the 6-31G(d) basis set for the molecular species while the primary solvent shell consisting of 45 DMF molecules was treated by the MM method using the universal force field (UFF). Electronic energies of the neutral, anionic, and dianionic species were obtained by carrying out single point density functional theory (DFT) calculations using the 6-311+G(2d,2p) basis set on the respective ONIOM optimized geometries. The CHARMM27 force field was used to account for the dynamical nature of the primary solvation shell of 45 DMF molecules. In the calculations using solvent shells, the required atomic charges for each solvent molecule were obtained from ROB3LYP/6-31G(d) calculation on a single isolated DMF molecule. Randomly sampled configurations generated by the Monte Carlo (MC) technique were used to determine the contribution of the primary shell to the free energy of solvation of the three species. The dynamical nature of the primary shell significantly corrects the free energy of solvation. Frequency calculations at the ROB3LYP/6-31G(d) level were carried out on the optimized geometries of truncated 47-atom models of the neutral and ionic species in vacuum so as to determine the differences in thermal energy and molecular entropy. The Born energy of ion-dielectric interaction, the Onsager energy of dipole-dielectric interaction, and the Debye-Hückel energy of ion-ionic cloud interaction for the pheophytin-solvent aggregate were added as perturbative corrections. The Born interaction also makes a large contribution to the absolute free energy of reduction. An implicit solvation model (DPCM) was

  13. Three 2012 Transits of Venus: From Earth, Jupiter, and Saturn

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Schneider, G.; Babcock, B. A.; Lu, M.; Edelman, E.; Reardon, K.; Widemann, T.; Tanga, P.; Dantowitz, R.; Silverstone, M. D.; Ehrenreich, D.; Vidal-Madjar, A.; Nicholson, P. D.; Willson, R. C.; Kopp, G. A.; Yurchyshyn, V. B.; Sterling, A. C.; Scherrer, P. H.; Schou, J.; Golub, L.; McCauley, P.; Reeves, K.

    2013-01-01

    We observed the 2012 June 6/5 transit seen from Earth (E/ToV), simultaneously with Venus Express and several other spacecraft not only to study the Cytherean atmosphere but also to provide an exoplanet-transit analog. From Haleakala, the whole transit was visible in coronal skies; among our instruments was one of the world-wide Venus Twilight Experiment's nine coronagraphs. Venus's atmosphere became visible before first contact. SacPeak/IBIS provided high-resolution images at Hα/carbon-dioxide. Big Bear's NST also provided high-resolution observations of the Cytherean atmosphere and black-drop evolution. Our liaison with UH's Mees Solar Observatory scientists provided magneto-optical imaging at calcium and potassium. Solar Dynamics Observatory's AIA and HMI, and the Solar Optical Telescope (SOT) and X-ray Telescope (XRT) on Hinode, and total-solar-irradiance measurements with ACRIMSAT and SORCE/TIM, were used to observe the event as an exoplanet-transit analog. On September 20, we imaged Jupiter for 14 Hubble Space Telescope orbits, centered on a 10-hour ToV visible from Jupiter (J/ToV), as an exoplanet-transit analog in our own solar system, using Jupiter as an integrating sphere. Imaging was good, although much work remains to determine if we can detect the expected 0.01% solar irradiance decrease at Jupiter and the even slighter differential effect between our violet and near-infrared filters caused by Venus's atmosphere. We also give a first report on our currently planned December 21 Cassini UVIS observations of a transit of Venus from Saturn (S/ToV). Our E/ToV expedition was sponsored by the Committee for Research and Exploration/National Geographic Society; supplemented: NASA/AAS's Small Research Grant Program. We thank Rob Ratkowski, Stan Truitt, Rob Lucas, Aram Friedman, and Eric Pilger '82 at Haleakala, and Joseph Gangestad '06 at Big Bear for assistance, and Lockheed Martin Solar and Astrophysics Lab and Hinode science and operations teams for support

  14. Transit Observations of Venus's Atmosphere in 2012 from Terrestrial and Space Telescopes as Exoplanet Analogs

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Schneider, G.; Babcock, B. A.; Lu, M.; Penn, M. J.; Jaeggli, S. A.; Galayda, E.; Reardon, K. P.; Widemann, T.; Tanga, P.; Ehrenreich, D.; Vidal-Madjar, A.; Nicholson, P. D.; Dantowitz, R.

    2013-06-01

    We extensively observed the 8 June 2012 transit of Venus from several sites on Earth; we provide this interim status report about this and about two subsequent ToVs observed from space. From Haleakala Obs., we observed the entire June transit over almost 7 h with a coronagraph of the Venus Twilight Experiment B filter) and with a RED Epic camera to compare with simultaneous data from ESA's Venus Express, to study the Cytherean mesosphere; from Kitt Peak, we have near-IR spectropolarimetry at 1.6 µm from the aureole and during the disk crossing that compare well with carbon dioxide spectral models; from Sac Peak/IBIS we have high-resolution imaging of the Cytherean aureole for 22 min, starting even before 1st contact; from Big Bear, we have high-resolution imaging of Venus's atmosphere and the black-drop effect through 2nd contact; and we had 8 other coronagraphs around the world. For the Sept 21 ToV as seen from Jupiter, we had 14 orbits of HST to use Jupiter's clouds as a reflecting surface to search for an 0.01% diminution in light and a differential drop that would result from Venus's atmosphere by observing in both IR/UV, for which we have 170 HST exposures. As of this writing, preliminary data reduction indicates that variations in Jovian clouds and the two periods of Jupiter's rotation will be too great to allow extraction of the transit signal. For the December 20 ToV as seen from Saturn, we had 22 hours of observing time with VIMS on Cassini, for which we are looking for a signal of the 10-hr transit in total solar irradiance and of Venus's atmosphere in IR as an exoplanet-transit analog. Our Maui & Sac Peak expedition was sponsored by National Geographic Society's Committee for Research and Exploration; HST data reduction by NASA: HST-GO-13067. Some of the funds for the carbon dioxide filter for Sac Peak provided by NASA through AAS's Small Research Grant Program. We thank Rob Ratkowski of Haleakala Amateur Astronomers; Rob Lucas, Aram Friedman, Eric

  15. Effect of solar radio bursts on GNSS signal reception over Europe for the period 1999-2013

    NASA Astrophysics Data System (ADS)

    Chevalier, Jean-Marie; Bergeot, Nicolas; Marqué, Christophe; Aerts, Wim; Bruyninx, Carine

    2015-04-01

    Intense solar radio bursts (SRB) emitted at L-band frequencies can affect the carrier-to-noise C/N0 ratio of Global Navigation Satellite Systems (GNSS) signals by increasing the background noise. Such space weather events can consequently decrease the quality of GNSS-based results especially for kinematic high-precision positioning. It is thus important to develop a method capable to detect such events in near real time on a wide area. For this purpose, the ROB-IONO software was adapted for analysing the effect of SRB on the dense EUREF Permanent GNSS Network (EPN). First, S1 and S2 raw data extracted from RINEX files were converted into the C/N0 unit (dB.Hz) taking into account manufacturer corrections. Then, the differences (ΔC/N0) between all these C/N0observables and their medians of the 7 previous satellite ground track repeat cycles, i.e. their normal quiet state, were computed. The mean of all these well-calibrated ΔC/N0values from different GNSS receivers and satellites offer at each epoch a reliable metric to detect and quantify the impact of a SRB. We investigated the degradation of GPS and GLONASS C/N0 on the entire EPN during 10 intense SRBs occurring at daylight over Europe between 1999 and 2013. The analysis shows that: (1) GPS and GLONASS ΔC/N0 agree at the 0.1±0.2dB.Hz level; (2) The standard deviation of the mean ΔC/N0of the EPN GNSS receivers is below 1dB.Hz 96% of the time, and below 0.6dB.Hz 76% of the time; (3) maximum ΔC/N0 degradation occurs at the epoch of maximum solar peak flux delivered by the solar ground observatories; (4) C/N0 degradation becomes larger with increasing solar zenithal angle. Consequently, the ROB-IONO software is capable to detect the degradation of GNSS signal reception over Europe due to SRBs. In addition, by taking advantage of the increasing number of EPN stations delivering C/N0 data since 2005, even less intense SRB events can now be detected. Finally, the developed method can be completely applied in near

  16. Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease

    PubMed Central

    Klima, Cassidy L.; Alexander, Trevor W.; Hendrick, Steve; McAllister, Tim A.

    2014-01-01

    Mannheimia haemolytica is the principal bacterial pathogen associated with bovine respiratory disease (BRD). As an opportunistic pathogen, M. haemolytica is also frequently isolated from the respiratory tract of healthy cattle. This study examined the characteristics of M. haemolytica collected using deep nasal swabs from healthy cattle (n = 49) and cattle diagnosed with BRD (n = 41). Isolates were analyzed by pulsed-field gel electrophoresis (PFGE), serotyped, and tested for antimicrobial susceptibility. Polymerase chain reaction (PCR) was used to screen isolates for virulence [leukotoxin C (lktC), putative adhesin (ahs), outer-membrane lipoprotein (gs60), O-sialoglycoprotease (gcp), transferring-binding protein B (tbpB) and UDP-N-acetyl-D-glucosamine-2-epimerase (nmaA)] and antimicrobial resistance [tet(H), blaROB-1, erm(X), erm(42), msr(E)-mph(E) and aphA-1] genes. Isolates were genetically diverse but in three instances, M. haemolytica with the same pulsotype, resistance phenotype, and genotype were collected from cattle with BRD. This occurred once between cattle located in two different feedlots, once between cattle in the same feedlot, but in different pens, and once among cattle from the same feedlot in the same pen. Isolates from healthy cattle were primarily serotype 2 (75.5%) while those from individuals with BRD were serotype 1 (70.7%) or 6 (19.5%). Resistance to at least one antibiotic occurred more frequently (P < 0.001) in M. haemolytica collected from cattle with BRD (37%) compared with those that were healthy (2%). Overall, tetracycline resistance (18%) was the most prevalent resistant phenotype. All tetracycline-resistant M. haemolytica encoded tet(H). Ampicillin resistance (6%) and neomycin resistance (15%) were detected and corresponded to the presence of the blaROB-1 and aphA-1 genes, respectively. Tilmicosin resistance (6%) was also detected, but the resistance genes responsible were not identified. The virulence genes lktC, ahs, gs60, and gcp

  17. Momentum and energy dependent resolution function of the ARCS neutron chopper spectrometer at high momentum transfer: Comparing simulation and experiment

    NASA Astrophysics Data System (ADS)

    Diallo, S. O.; Lin, J. Y. Y.; Abernathy, D. L.; Azuah, R. T.

    2016-11-01

    Inelastic neutron scattering at high momentum transfers (i.e. Q ≥ 20 A ˚), commonly known as deep inelastic neutron scattering (DINS), provides direct observation of the momentum distribution of light atoms, making it a powerful probe for studying single-particle motions in liquids and solids. The quantitative analysis of DINS data requires an accurate knowledge of the instrument resolution function Ri(Q , E) at each momentum Q and energy transfer E, where the label i indicates whether the resolution was experimentally observed i = obs or simulated i=sim. Here, we describe two independent methods for determining the total resolution function Ri(Q , E) of the ARCS neutron instrument at the Spallation Neutron Source, Oak Ridge National Laboratory. The first method uses experimental data from an archetypical system (liquid 4He) studied with DINS, which are then numerically deconvoluted using its previously determined intrinsic scattering function to yield Robs(Q , E). The second approach uses accurate Monte Carlo simulations of the ARCS spectrometer, which account for all instrument contributions, coupled to a representative scattering kernel to reproduce the experimentally observed response S(Q , E). Using a delta function as scattering kernel, the simulation yields a resolution function Rsim(Q , E) with comparable lineshape and features as Robs(Q , E), but somewhat narrower due to the ideal nature of the model. Using each of these two Ri(Q , E) separately, we extract characteristic parameters of liquid 4He such as the intrinsic linewidth α2 (which sets the atomic kinetic energy < K > ∼α2) in the normal liquid and the Bose-Einstein condensate parameter n0 in the superfluid phase. The extracted α2 values agree well with previous measurements at saturated vapor pressure (SVP) as well as at elevated pressure (24 bars) within experimental precision, independent of which Ri(Q , y) is used to analyze the data. The actual observed n0 values at each Q vary little

  18. Climate change impact on groundwater levels in the Guarani Aquifer outcrop zone

    NASA Astrophysics Data System (ADS)

    Melo, D. D.; Wendland, E.

    2013-12-01

    The unsustainable use of groundwater in many countries might cause water availability restrictions in the future. Such issue is likely to worsen due to predicted climate changes for the incoming decades. As numerous studies suggest, aquifers recharge rates will be affected as a result of climate change. The Guarani Aquifer System (GAS) is one of the most important transboundary aquifer in the world, providing drinkable water for millions of people in four South American countries (Brazil, Argentina, Uruguay and Paraguay). Considering the GAS relevance and how its recharge rates might be altered by climatic conditions anomalies, the objective of this work is to assess possible climate changes impacts on groundwater levels in this aquifer outcrop zone. Global Climate Models' (GCM) outputs were used as inputs in a transient flux groundwater model created using the software SPA (Simulation of Process in Aquifers), enabling groundwater table fluctuation to be evaluated under distinct climatic scenarios. Six monitoring wells, located in a representative basin (Ribeirão da Onça basin) inside a GAS outcrop zone (ROB), provided water table measurements between 2004 and 2011 to calibrate the groundwater model. Using observed climatic data, a water budget method was applied to estimate recharge in different types of land uses. Statistically downscaled future climate scenarios were used as inputs for that same recharge model, which provided data for running SPA under those scenarios. The results show that most of the GCMs used here predict temperature arises over 275,15 K and major monthly rainfall mean changes to take place in the dry season. During wet seasons, those means might experience around 50% decrease. The transient model results indicate that water table variations, derived from around 70% of the climate scenarios, would vary below those measured between 2004 and 2011. Among the thirteen GCMs considered in this work, only four of them predicted more extreme

  19. Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease.

    PubMed

    Klima, Cassidy L; Alexander, Trevor W; Hendrick, Steve; McAllister, Tim A

    2014-01-01

    Mannheimia haemolytica is the principal bacterial pathogen associated with bovine respiratory disease (BRD). As an opportunistic pathogen, M. haemolytica is also frequently isolated from the respiratory tract of healthy cattle. This study examined the characteristics of M. haemolytica collected using deep nasal swabs from healthy cattle (n = 49) and cattle diagnosed with BRD (n = 41). Isolates were analyzed by pulsed-field gel electrophoresis (PFGE), serotyped, and tested for antimicrobial susceptibility. Polymerase chain reaction (PCR) was used to screen isolates for virulence [leukotoxin C (lktC), putative adhesin (ahs), outer-membrane lipoprotein (gs60), O-sialoglycoprotease (gcp), transferring-binding protein B (tbpB) and UDP-N-acetyl-D-glucosamine-2-epimerase (nmaA)] and antimicrobial resistance [tet(H), bla ROB-1, erm(X), erm(42), msr(E)-mph(E) and aphA-1] genes. Isolates were genetically diverse but in three instances, M. haemolytica with the same pulsotype, resistance phenotype, and genotype were collected from cattle with BRD. This occurred once between cattle located in two different feedlots, once between cattle in the same feedlot, but in different pens, and once among cattle from the same feedlot in the same pen. Isolates from healthy cattle were primarily serotype 2 (75.5%) while those from individuals with BRD were serotype 1 (70.7%) or 6 (19.5%). Resistance to at least one antibiotic occurred more frequently (P < 0.001) in M. haemolytica collected from cattle with BRD (37%) compared with those that were healthy (2%). Overall, tetracycline resistance (18%) was the most prevalent resistant phenotype. All tetracycline-resistant M. haemolytica encoded tet(H). Ampicillin resistance (6%) and neomycin resistance (15%) were detected and corresponded to the presence of the bla ROB-1 and aphA-1 genes, respectively. Tilmicosin resistance (6%) was also detected, but the resistance genes responsible were not identified. The virulence genes lktC, ahs, gs60, and

  20. Novel Applications of Peroxidase

    NASA Astrophysics Data System (ADS)

    Rob, Abdul; Ball, Andrew S.; Tuncer, Munir; Wilson, Michael T.

    1997-02-01

    . Warhol, M. J.; Heitz, P. U. Lab. Invest. 1992, 67, 263-269. 9. Pergande, M.; Jung, K. Clin. Chem. 1993, 39, 1885-1890. 10. Allain, C. C; Poon, L. S.; Chan, C. S. G; Richmond, W.; Fu, P. C. Clin. Chem. 1974, 20, 470-475. 11. Rob, A; Ball, A. S.; Tuncer, M; Wilson, M. T. Biochem. Soc. Trans. 1995, 23, 507. 12. Rob, A.; Ball, A. S.; Tuncer, M.; Jones, G. D.; Taylor, P. D; Wilson, M. T. Biochem. Soc. Trans. 1996, 24, 455.

  1. Explaining the variability of Photochemical Reflectance Index (PRI): deconvolution of variability related to Light Use Efficiency and Canopy attributes.

    NASA Astrophysics Data System (ADS)

    Merlier, Elodie; Hmimina, Gabriel; Dufrêne, Eric; Soudani, Kamel

    2014-05-01

    . 1992. A narrow-waveband spectral index that tracks diurnal changes in photosynthetic efficiency. Remote Sensing of Environment 41, 35-44. Garbulsky MF, Peñuelas J, Gamon J, Inoue Y, Filella I. 2011. The photochemical reflectance index (PRI) and the remote sensing of leaf, canopy and ecosystem radiation use efficiencies: A review and meta-analysis. Remote Sensing of Environment 115, 281-297. Hilker T, Coops NC, Hall FG, Black TA, Wulder MA, Nesic Z, Krishnan P. 2008. Separating physiologically and directionally induced changes in PRI using BRDF models. Remote Sensing of Environment 112, 2777-2788. Hmimina G, Dufrêne E, Soudani K. 2014. Relationship between PRI and leaf ecophysiological and biochemical parameters under two different water statuses: toward a rapid and efficient correction method using real-time measurements. Plant, Cell & Environment 37, 2, 473-487. Nakaji T, Oguma H, Fujinuma Y. 2006. Seasonal changes in the relationship between photochemical reflectance index and photosynthetic light use efficiency of Japanese larch needles. International Journal of Remote Sensing 27, 493-509. Rahimzadeh-Bajgiran P, Munehiro M, Omasa K. 2012. Relationships between the photochemical reflectance index (PRI) and chlorophyll fluorescence parameters and plant pigment indices at different leaf growth stages. Photosynthesis Research 113, 261-271.

  2. PREFACE: Proceedings of the 2008 Numerical Relativity Data Analysis Meeting, Syracuse University, Syracuse, NY, USA, 11-14 August 2008 Proceedings of the 2008 Numerical Relativity Data Analysis Meeting, Syracuse University, Syracuse, NY, USA, 11-14 August 2008

    NASA Astrophysics Data System (ADS)

    Sutton, Patrick; Shoemaker, Deirdre

    2009-06-01

    many of the highlights of the meeting. These include an article that summarizes the NINJA project, a collaboration between data analysts and numerical relativists that is testing data analysis pipelines on numerical relativity waveforms buried in simulated detector noise. In addition, there are several technical papers concerning the results of team efforts involved in NINJA. Also included is a review of the status of black-hole simulations, updates on black-hole and neutron-star sources of gravitational waves, accuracy tests of gravitational waveforms, binary parameter estimation methods, updates on searches using analytic and phenomenological waveforms, and a road map to the advanced LIGO detectors. The conference organizers would like to acknowledge the financial support of the National Science Foundation under grant number PHY-0838740, and support from Syracuse University. We thank the local organizing committee of Duncan Brown, Penny Davis and Joshua Smith as well as the other members of the scientific organizing committee of Duncan Brown (Syracuse University), Sascha Husa (AEI), Badri Krishnan (AEI) and Harald Pfeiffer (CITA) for putting together an exciting conference. We also thank the editorial staff of the journal Classical and Quantum Gravity, especially Adam Day, Suzanne Prescott, and Joseph Tennant for their assistance, support, and patience in preparing this issue. Finally, we would like to thank the participants of NRDA2008 for making this conference so vital and energizing. The next NRDA meeting will be held at the Albert Einstein Institute in Potsdam, Germany 6-9 July 2009. We look forward to new collaborations, and to the continued blurring of the lines between our communities as we explore the interface of numerical relativity and data analysis. Patrick Sutton, Cardiff University and Deirdre Shoemaker, Georgia Institute of Technology Guest Editors

  3. A flow visualization study of single-arm sculling movement emulating cephalopod thrust generation

    NASA Astrophysics Data System (ADS)

    Kazakidi, Asimina; Gnanamanickam, Ebenezer P.; Tsakiris, Dimitris P.; Ekaterinaris, John A.

    2014-11-01

    In addition to jet propulsion, octopuses use arm-swimming motion as an effective means of generating bursts of thrust, for hunting, defense, or escape. The individual role of their arms, acting as thrust generators during this motion, is still under investigation, in view of an increasing robotic interest for alternative modes of propulsion, inspired by the octopus. Computational studies have revealed that thrust generation is associated with complex vortical flow patterns in the wake of the moving arm, however further experimental validation is required. Using the hydrogen bubble technique, we studied the flow disturbance around a single octopus-like robotic arm, undergoing two-stroke sculling movements in quiescent fluid. Although simplified, sculling profiles have been found to adequately capture the fundamental kinematics of the octopus arm-swimming behavior. In fact, variation of the sculling parameters alters considerably the generation of forward thrust. Flow visualization revealed the generation of complex vortical structures around both rigid and compliant arms. Increased disturbance was evident near the tip, particularly at the transitional phase between recovery and power strokes. These results are in good qualitative agreement with computational and robotic studies. Work funded by the ESF-GSRT HYDRO-ROB Project PE7(281).

  4. Correlation of HI shells and CO clumps in the outer Milky Way

    NASA Astrophysics Data System (ADS)

    Ehlerová, S.; Palouš, J.

    2016-03-01

    Context. HI shells, which may be formed by the activity of young and massive stars, or connected to energy released by interactions of high-velocity clouds with the galactic disk, may be partly responsible both for the destruction of CO clouds and for the creation of others. It is not known which effect prevails. Aims: We study the relation between HI shells and CO in the outer parts of the Milky Way, using HI and CO surveys and a catalogue of previously identified HI shells. Methods: For each individual location, the distance to the nearest HI shell is calculated and it is specified whether it lies in the interior of an HI shell, in its walls, or outside an HI shell. The method takes into account irregular shapes of HI shells. Results: We find a lack of CO clouds in the interiors of HI shells and their increased occurrence in walls. Properties of clouds differ for different environments: interiors of HI shells, their walls, and unperturbed medium. Conclusions: CO clouds found in the interiors of HI shells are those that survived and were robbed of their more diffuse gas. Walls of HI shells have a high molecular content, indicative of an increased rate of CO formation. Comparing the CO fractions within HI shells and outside in the unperturbed medium, we conclude that HI shells are responsible for a ~20% increase in the total amount of CO in the outer Milky Way.

  5. Workplace Homicides Among U.S. Women: The Role of Intimate Partner Violence

    PubMed Central

    Tiesman, Hope M.; Gurka, Kelly K.; Konda, Srinivas; Coben, Jeffrey H.; Amandus, Harlan E.

    2015-01-01

    PURPOSE Intimate partner violence (IPV) is an important public health issue with serious consequences for the workplace. Workplace homicides occurring to U.S. women over a 6-year period, including those perpetrated by an intimate partner, are described. METHODS Workplace homicides among U.S. women from 2003 to 2008 were categorized into type I (criminal intent), type II (customer/client), type III (co-worker), or type IV (personal relations) events using the Census of Fatal Occupational Injuries. Fatality rates were calculated and compared among workplace violence (WPV) types, occupations, and characteristics including location of homicide, type of workplace, time of day, and weapon used. RESULTS Between 2003 and 2008, 648 women were feloniously killed on the job. The leading cause of workplace homicide for U.S. women was criminal intent, such as robbing a store (n = 212; 39%), followed by homicides perpetrated by a personal relation (n= 181; 33%). The majority of these personal relations were intimate partners (n = 142; 78%). Over half of workplace homicides perpetrated by intimate partners occurred in parking lots and public buildings (n = 91; 51%). CONCLUSIONS A large percentage of homicides occurring to women at work are perpetrated by intimate partners. WPV prevention programs should incorporate strategies to prevent and respond to IPV. PMID:22463843

  6. Geometry, analysis, and computation in mathematics and applied sciences. Final report

    SciTech Connect

    Kusner, R.B.; Hoffman, D.A.; Norman, P.; Pedit, F.; Whitaker, N.; Oliver, D.

    1995-12-31

    Since 1993, the GANG laboratory has been co-directed by David Hoffman, Rob Kusner and Peter Norman. A great deal of mathematical research has been carried out here by them and by GANG faculty members Franz Pedit and Nate Whitaker. Also new communication tools, such as the GANG Webserver have been developed. GANG has trained and supported nearly a dozen graduate students, and at least half as many undergrads in REU projects.The GANG Seminar continues to thrive, making Amherst a site for short and long term visitors to come to work with the GANG. Some of the highlights of recent or ongoing research at GANG include: CMC surfaces, minimal surfaces, fluid dynamics, harmonic maps, isometric immersions, knot energies, foam structures, high dimensional soap film singularities, elastic curves and surfaces, self-similar curvature evolution, integrable systems and theta functions, fully nonlinear geometric PDE, geometric chemistry and biology. This report is divided into the following sections: (1) geometric variational problems; (2) soliton geometry; (3) embedded minimal surfaces; (4) numerical fluid dynamics and mathematical modeling; (5) GANG graphics and mathematical software; (6) description of the computational and visual analysis facility; and (7) research by undergraduates and GANG graduate seminar.

  7. N-Acetylcysteine Suppresses Retinal Detachment in an Experimental Model of Proliferative Vitreoretinopathy

    PubMed Central

    Lei, Hetian; Velez, Gisela; Cui, Jing; Samad, Arif; Maberley, David; Matsubara, Joanne; Kazlauskas, Andrius

    2010-01-01

    Proliferative vitreoretinopathy (PVR) is a complication that develops in 5% to 10% of patients who undergo surgery to correct a detached retina. The only treatment option for PVR is surgical intervention, which has a limited success rate that diminishes in patients with recurring PVR. Our recent studies revealed that antioxidants prevented intracellular signaling events that were essential for experimental PVR. The purpose of this study was to test whether N-acetyl-cysteine (NAC), an antioxidant used in a variety of clinical settings, was capable of protecting rabbits from PVR. Vitreous-driven activation of PDGFRα and cellular responses intrinsic to PVR (contraction of collagen gels and cell proliferation) were blocked by concentrations of NAC that were well below the maximum tolerated dose. Furthermore, intravitreal injection of NAC effectively protected rabbits from developing retinal detachment, which is the sight-robbing phase of PVR. Finally, these observations with an animal model appear relevant to clinical PVR because NAC prevented human PVR vitreous-induced contraction of primary RPE cells derived from a human PVR membrane. Our observations demonstrate that antioxidants significantly inhibited experimental PVR, and suggest that antioxidants have the potential to function as a PVR prophylactic in patients undergoing retinal surgery to repair a detached retina. PMID:20489144

  8. Photographic observations of visual double stars at Pulkovo: Digitization, measurement, and calibration

    NASA Astrophysics Data System (ADS)

    Izmailov, I. S.; Roshchina, E. A.; Kiselev, A. A.; Kiseleva, T. P.; Kalinichenko, O. A.; Bykov, O. P.; Kiyaeva, O. V.; Romanenko, L. G.; Shakht, N. A.; Maslennikov, K. L.; Vasil'eva, T. A.

    2016-01-01

    We present the results of determining the relative positions of 359 pairs of stars. More than 6000 photographic plates were obtained in 1960-2007 at the 26-inch refractor of the Pulkovo Observatory. The plates have been digitized with a Canon EOS 5D Mark II digital camera and a long-focus Jupiter 21M lens; the scalewas 21 μm/pixel. Themeasurements have been calibrated using a template digitized with the Belgian high-precision ROB Digitizer. The results have been thoroughly investigated for systematic errors. We have studied the scale of the 26-inch refractor and revealed its temperature and time dependences. The application of a new digitization, measurement, and calibration technique has allowed the accuracy to be increased compared to the past measurements. The single-exposure measurement accuracy is within the range from 2 to 70 mas, on average, 28 mas in both coordinates. The errors of the yearly mean positions are, on average, 8.7 mas in the angular separation and 0.05◦. in the position angle.

  9. Chlorogenic acid content, essential oil compositions, and in vitro antioxidant activities of Chromolaena odorata leaves.

    PubMed

    Pitakpawasutthi, Yamon; Thitikornpong, Worathat; Palanuvej, Chanida; Ruangrungsi, Nijsiri

    2016-01-01

    Chromolaena odorata (L.) R. M. King and H. Rob. is a Thai medicinal plant used for the treatment of wounds, rashes, diabetes, and insect repellent. The leaves of C. odorata were collected from 10 different sources throughout Thailand. The chemical constituents of essential oils were hydro-distilled from the leaves and were analyzed by gas chromatography-mass spectrometry. Chlorogenic acid contents were determined by thin-layer chromatography (TLC) - densitometry with winCATS software and TLC image analysis with ImageJ software. The TLC plate was developed in the mobile phase that consisted of ethyl acetate:water:formic acid (17:3:2). Antioxidant activities were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging and β-carotene bleaching assays. C. odorata essential oil has shown the major components of pregeijerene, dauca-5, 8-diene, (E)-caryophyllene, β-pinene, and α-pinene. The chlorogenic acid content of C. odorata leaves was determined by TLC-densitometry and TLC image analysis. Results have shown that TLC-densitometry and TLC image analysis method were not statistically significantly different. DPPH radical scavenging and β-carotene bleaching assays of ethanolic extract of C. odorata leaves showed its antioxidant potential.

  10. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro

    PubMed Central

    Guha, Gunjan; Rajkumar, V.; Ashok Kumar, R.; Mathew, Lazar

    2011-01-01

    Cyanthillium cinereum (Less.) H. Rob. (Asteraceae) has been traditionally known for its medicinal properties, all aspects of which are yet to be exploited. This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant. Several parameters including free-radical (DPPH•, ABTS•+, H2O2 and •OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined. All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts. However, only the hexane extract showed significant H2O2 scavenging effect. Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and a high degree of inhibition was shown by all the extracts. Reducing power of the polar extracts was higher than the non-polar ones. All extracts showed a concentration-dependent increase in phenolic contents. Oxidative damage to erythrocytes was hindered by all extracts in diverse degrees. XTT assay showed that all extracts have mild cytotoxic property. The aqueous extract evidently demonstrated protective effect on pBR322 plasmid DNA against oxidative breakdown. These results suggested the potential of C. cinereum as medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity. PMID:19875433

  11. Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro.

    PubMed

    Guha, Gunjan; Rajkumar, V; Ashok Kumar, R; Mathew, Lazar

    2011-01-01

    Cyanthillium cinereum (Less.) H. Rob. (Asteraceae) has been traditionally known for its medicinal properties, all aspects of which are yet to be exploited. This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant. Several parameters including free-radical (DPPH(•), ABTS(•+), H(2)O(2) and (•)OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined. All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts. However, only the hexane extract showed significant H(2)O(2) scavenging effect. Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and a high degree of inhibition was shown by all the extracts. Reducing power of the polar extracts was higher than the non-polar ones. All extracts showed a concentration-dependent increase in phenolic contents. Oxidative damage to erythrocytes was hindered by all extracts in diverse degrees. XTT assay showed that all extracts have mild cytotoxic property. The aqueous extract evidently demonstrated protective effect on pBR322 plasmid DNA against oxidative breakdown. These results suggested the potential of C. cinereum as medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity. PMID:19875433

  12. Diagnostic methods for mastitis in cows are not appropriate for use in humans: commentary.

    PubMed

    Kvist, Linda J

    2016-01-01

    Healthcare workers are now being targeted for marketing of diagnostic tools for mastitis that were developed for the dairy industry and which aim to provide information regarding choice of antibiotic treatment. Meanwhile, scientists are striving to understand how the human microbiome affects health and wellbeing and the importance of maintenance of bacterial balance in the human body. Breast milk supplies a multitude of bacteria to populate the baby's intestinal tract and kick-start the immune system. Researchers propose a paradigm shift in the understanding of bacterial content in breast milk and an alternative paradigm for the understanding of lactational mastitis: there is the beginning of evidence that many cases of lactational mastitis will resolve spontaneously. An international group of researchers is attempting to answer how dietary habits, birth mode, genetics and environmental factors may impact the bacterial content of breast milk. Until we have more comprehensive knowledge about the human milk microbiome, diagnostic aids for identification of women in need of antibiotic therapy for mastitis remain unreliable. Diagnostic aids could lead to the injudicious use of antibiotic therapy, which in turn may rob the infant of bacteria valuable for development of its immune system. The marketing of diagnostic aids for use in human medicine, that were originally developed for use in cows, is neither evidence-based nor good ethical practice. PMID:26877759

  13. The impact of phloem nutrients on overwintering mountain pine beetles and their fungal symbionts.

    PubMed

    Goodsman, Devin W; Erbilgin, Nadir; Lieffers, Victor J

    2012-06-01

    In the low nutrient environment of conifer bark, subcortical beetles often carry symbiotic fungi that concentrate nutrients in host tissues. Although bark beetles are known to benefit from these symbioses, whether this is because they survive better in nutrient-rich phloem is unknown. After manipulating phloem nutrition by fertilizing lodgepole pine trees (Pinus contorta Douglas var. latifolia), we found bolts from fertilized trees to contain more living individuals, and especially more pupae and teneral adults than bolts from unfertilized trees at our southern site. At our northern site, we found that a larger proportion of mountain pine beetle (Dendroctonus ponderosae Hopkins) larvae built pupal chambers in bolts from fertilized trees than in bolts from unfertilized trees. The symbiotic fungi of the mountain pine beetle also responded to fertilization. Two mutualistic fungi of bark beetles, Grosmannia clavigera (Rob.-Jeffr. & R. W. Davidson) Zipfel, Z. W. de Beer, & M. J. Wingf. and Leptographium longiclavatum Lee, S., J. J. Kim, & C. Breuil, doubled the nitrogen concentrations near the point of infection in the phloem of fertilized trees. These fungi were less capable of concentrating nitrogen in unfertilized trees. Thus, the fungal symbionts of mountain pine beetle enhance phloem nutrition and likely mediate the beneficial effects of fertilization on the survival and development of mountain pine beetle larvae. PMID:22732605

  14. Ferenczi's concept of identification with the aggressor: understanding dissociative structure with interacting victim and abuser self-states.

    PubMed

    Howell, Elizabeth F

    2014-03-01

    No one has described more passionately than Ferenczi the traumatic induction of dissociative trance with its resulting fragmentation of the personality. Ferenczi introduced the concept and term, identification with the aggressor in his seminal "Confusion of Tongues" paper, in which he described how the abused child becomes transfixed and robbed of his senses. Having been traumatically overwhelmed, the child becomes hypnotically transfixed by the aggressor's wishes and behavior, automatically identifying by mimicry rather than by a purposeful identification with the aggressor's role. To expand upon Ferenczi's observations, identification with the aggressor can be understood as a two-stage process. The first stage is automatic and initiated by trauma, but the second stage is defensive and purposeful. While identification with the aggressor begins as an automatic organismic process, with repeated activation and use, gradually it becomes a defensive process. Broadly, as a dissociative defense, it has two enacted relational parts, the part of the victim and the part of the aggressor. This paper describes the intrapersonal aspects (how aggressor and victim self-states interrelate in the internal world), as well as the interpersonal aspects (how these become enacted in the external). This formulation has relevance to understanding the broad spectrum of the dissociative structure of mind, borderline personality disorder, and dissociative identity disorder. PMID:24603172

  15. Reflections about bizarre mummification practices on mummies at Egypt's Dakhleh oasis: a review.

    PubMed

    Aufderheide, Arthur C

    2009-12-01

    About 100 mummified human remains were excavated from the Dakhleh Oasis in Egypt's Western Desert. Of these, less than half were examined by dissection. These dated to the Late Ptolemaic and Roman Periods. Initially, a confusing pattern of mortuary mummification practices was encountered that was identified ultimately as a product of primarily initial spontaneous mummification by desiccation. This was followed by tomb robbing in antiquity with unwrapping; body disarticulation followed, in turn, by mummy body reconstruction with atypical use of resin applications. Some of the resin was shown to be contaminated by bitumen that was responsible for inappropriately old radiocarbon dates of mummy tissue samples. Chemical reconstruction of diet using stable isotope ratios of carbon and nitrogen characterized their diet to be primarily that of C3 plants, consistent with trading records excavated from that site. Analysis of the mummy coprolites also enabled the first finding of the intestinal parasite Enterobius vermicularis in either ancient or modern Egyptian human coprolites. The principal focus of this report is to demonstrate and verify the value of including visceral dissection as part of a mummy examination whenever possible. PMID:20440958

  16. Schlemm, the body snatcher?

    PubMed

    Winkelmann, Andreas

    2008-01-01

    Friedrich Schlemm (1795-1858) is well known for his original description of the scleral venous sinus, known since as Schlemm's canal. He grew up in a village in the Duchy of Braunschweig (Brunswick). As his family could not afford higher education, he was apprenticed to a barber-surgeon in Braunschweig. This gave him the opportunity to study anatomy and surgery at the local Anatomico-Surgical Institute. Recently discovered archival sources demonstrate that, in June of 1816, Schlemm and a fellow student disinterred the body of a deceased woman late at night in a Braunschweig churchyard to bring the body to this Institute and study the effects of rickets on the woman's bones. They were caught and sentenced to 4 weeks of prison. Subsequently, Schlemm left Braunschweig and found work as a low-rank army surgeon in Berlin. Professor Rudolphi, the director of the Berlin Institute of Anatomy, took note of Schlemm's manual dexterity in anatomical dissection and supported his impressive career. Schlemm eventually became full professor of anatomy in 1833 and spent his remaining 25 years in Berlin with a focus on teaching students and training surgeons. As historical background information is largely lacking in this regard, it is impossible to decide whether Schlemm's episode of grave robbing was a solitary instance or a more common method of acquiring bodies for anatomical instruction in early 19th century Germany. PMID:18396022

  17. Optical signatures of high-redshift galaxy clusters

    NASA Technical Reports Server (NTRS)

    Evrard, August E.; Charlot, Stephane

    1994-01-01

    We combine an N-body and gasdynamic simulation of structure formation with an updated population synthesis code to explore the expected optical characteristics of a high-redshift cluster of galaxies. We examine a poor (2 keV) cluster formed in a biased, cold dark matter cosmology and employ simple, but plausible, threshold criteria to convert gas into stars. At z = 2, the forming cluster appears as a linear chain of very blue (g-r approximately equals 0) galaxies, with 15 objects brighter than r = 25 within a 1 square arcmin field of view. After 2 Gyr of evolution, the cluster viewed at z = 1 displays both freshly infalling blue galaxies and red galaxies robbed of recent accretion by interaction with the hot intracluster medium. The range in G-R colors is approximately 3 mag at z = 1, with the reddest objects lying at sites of highest galaxy density. We suggest that red, high-redshift galaxies lie in the cores of forming clusters and that their existence indicates the presence of a hot intracluster medium at redshifts z approximately equals 2. The simulated cluster viewed at z = 2 has several characteristics similar to the collection of faint, blue objects identified by Dressler et al. in a deep Hubble Space Telescope observation. The similarities provide some support for the interpretation of this collection as a high-redshift cluster of galaxies.

  18. Ferenczi's concept of identification with the aggressor: understanding dissociative structure with interacting victim and abuser self-states.

    PubMed

    Howell, Elizabeth F

    2014-03-01

    No one has described more passionately than Ferenczi the traumatic induction of dissociative trance with its resulting fragmentation of the personality. Ferenczi introduced the concept and term, identification with the aggressor in his seminal "Confusion of Tongues" paper, in which he described how the abused child becomes transfixed and robbed of his senses. Having been traumatically overwhelmed, the child becomes hypnotically transfixed by the aggressor's wishes and behavior, automatically identifying by mimicry rather than by a purposeful identification with the aggressor's role. To expand upon Ferenczi's observations, identification with the aggressor can be understood as a two-stage process. The first stage is automatic and initiated by trauma, but the second stage is defensive and purposeful. While identification with the aggressor begins as an automatic organismic process, with repeated activation and use, gradually it becomes a defensive process. Broadly, as a dissociative defense, it has two enacted relational parts, the part of the victim and the part of the aggressor. This paper describes the intrapersonal aspects (how aggressor and victim self-states interrelate in the internal world), as well as the interpersonal aspects (how these become enacted in the external). This formulation has relevance to understanding the broad spectrum of the dissociative structure of mind, borderline personality disorder, and dissociative identity disorder.

  19. Cellular model studies of brain-mediated phototherapy on Alzheimer's disease

    NASA Astrophysics Data System (ADS)

    Zhu, Ling; Liu, Timon Cheng-Yi; Hu, Bina; Li, Xiao-Yun; Wang, Yong-Qing

    2008-12-01

    Alzheimer's disease (AD) is now the most common neurodegenerative disease. Despite approval of several drugs for AD, the disease continues to rob millions of their memories and their lives. We have studied the cellular models of brain-mediated phototherapy on AD, and the studies will be reviewed in this paper. Genetic studies have shown that dysfunction of amyloid β-protein (Aβ) or tau is sufficient to cause AD. Aβ or Aβ induced redox stress induced neuron apoptosis might be as a cellular model of AD. We found red light at 640+/-15 nm from light emitting diode array (RLED640) might inhibit Aβ 25-35 induced PC12 cell apoptosis, which is mediated by cyclic adenosine monophosphate, and it might inhibit hydrogen peroxide (H2O2) induced differentiated PC12 cell (dPC12) apoptosis, which is mediated by tyrosine hydroxylase. There is rhythm dysfunction in AD. We found low intensity 810 nm laser irradiation might rehabilitate TNF-alpha induced inhibition of clock gen expression of NIH 3T3 fibroblasts. Our studies provide a foundation for photobiomodulation on brain to rehabilitate AD.

  20. Dead-baby dreams, transfiguration and recovery from infant death trauma in northeast Brazil.

    PubMed

    Nations, Marilyn

    2013-10-01

    Maternal reactions to infant death in Northeast Brazil have been at the epicenter of anthropological debate since the 1980s. This ethnographic study of 45 death narratives by bereaved mothers collected from 1979-1989 in Pacatuba, Ceará, Brazil, refutes existing claims of mothers' "selective neglect" and "indifference" towards sick babies and emotionally empty grief response. I argue that through dead-baby dreams--and their imaginary transfiguration-grieving mothers alleviate infant death trauma. Feelings of hopelessness, helplessness, definitive loss, and personal guilt-the social seeds of depression--are reframed to deny death's finality and exonerate mothers from crippling self-blame. By transfiguring lingering mental images of the tiny cold corpse, mothers remold the irreversibility and definitiveness of death, gaining a sense of control over its unpredictable "jolt." In the politically oppressive Northeast Brazil--where social justice remains "an illusion"--mothers dream to preserve their own mental sanity and to recover from death's cruel aftermath. Any interpretation of mourning behavior must be contextualized within the local moral world and its "assumed structure of reality" to avoid demoralizing grieving Brazilian mothers and compounding their suffering. "You see, the only thing a poor woman truly owns that no one can borrow, cheat, steal or rob from her … is her imagination!" (Dona Chiquinha grieving death of her 10 children, Pacatuba, Ceará, Brazil).

  1. "What do these women want?": Feminist responses to Feminine Forever, 1963-1980.

    PubMed

    Houck, Judith A

    2003-01-01

    In 1963, Brooklyn gynecologist Robert A. Wilson and his wife, Thelma, published a paper in the Journal of the American Geriatrics Society arguing that untreated menopause robbed women of their femininity and ruined the quality of their lives. In 1966 Robert Wilson published a best-selling book, Feminine Forever, in which he maintained that menopause was an estrogen-deficiency disease that should be treated with estrogen replacement therapy to prevent the otherwise inevitable "living decay." This paper explores the issues raised by the convergence of Wilson's campaign and the emergence of the women's movement. Between 1963 and 1980, feminists did not respond with one voice to Wilson's ideas: at first, some embraced them as a boon for aging women, while others resisted regarding female aging as pathological. In 1975, studies linking ERT and endometrial cancer challenged the wisdom of routine hormone therapy; this shifted the tenor of the feminist discussion, but it did not create a consensus about the meaning of menopause or its treatment. Nevertheless, the feminist discussion of menopause revealed a larger women's health agenda-namely, the unyielding belief that women should retain control of their bodies and participate fully in the decision-making efforts regarding their health. By controlling their bodies, all women, whether feminist or not, could ultimately control their lives.

  2. Enhanced bioremediation of hydrocarbon-contaminated soil using pilot-scale bioelectrochemical systems.

    PubMed

    Lu, Lu; Yazdi, Hadi; Jin, Song; Zuo, Yi; Fallgren, Paul H; Ren, Zhiyong Jason

    2014-06-15

    Two column-type bioelectrochemical system (BES) modules were installed into a 50-L pilot scale reactor packed with diesel-contaminated soils to investigate the enhancement of passive biodegradation of petroleum compounds. By using low cost electrodes such as biochar and graphite granule as non-exhaustible solid-state electron acceptors, the results show that 82.1-89.7% of the total petroleum hydrocarbon (TPH) was degraded after 120 days across 1-34 cm radius of influence (ROI) from the modules. This represents a maximum of 241% increase of biodegradation compared to a baseline control reactor. The current production in the BESs correlated with the TPH removal, reaching the maximum output of 70.4 ± 0.2 mA/m(2). The maximum ROI of the BES, deducting influence from the baseline natural attenuation, was estimated to be more than 90 cm beyond the edge of the reactor (34 cm), and exceed 300 cm should a non-degradation baseline be used. The ratio of the projected ROI to the radius of BES (ROB) module was 11-12. The results suggest that this BES can serve as an innovative and sustainable technology for enhanced in situ bioremediation of petroleum hydrocarbons in large field scale, with additional benefits of electricity production and being integrated into existing field infrastructures.

  3. Secondary stem anatomy and uses of four drought-deciduous species of a tropical dry forest in México.

    PubMed

    Isaias, Alejandra Quintanar; Velázquez Núñez, Mariana; Solares Arenas, Fortunato; de la Paz Pérez Olvera, Carmen; Torre-Blanco, Alfonso

    2005-01-01

    Wood and bark anatomy and histochemistry of Acacia bilimekii Humb. & Bonpl., Acacia cochliacantha Mcbride, Conzatia nultiflora (Rob) Stand. and Guazuma ulmifolia Lam. are described from stem samples collected in a tropical dry forest (Morelos, Mexico). Enzyme activities were tested in tangential, radial and transverse cuts of fresh material. Histochemistry and stem anatomy were studied on similar cuts previously softened in a solution of water-glicerol-PEG. Our results show that the anatomical patterns of bark and wood, as well as the histochemical patterns and specific gravity, are influenced by water accessibility and climate; these patterns could guarantee mechanical and anti-infection strategies to support extreme conditions. Enzyme cytochemistry reveals biochemical activities probably related to lipid utilization routes for the lignification processes and for synthesis of extractives; these results suggest that the formation and maturation of woody tissue is very active at the beginning of the rainy season. These species are widely used by the local population. Traditional uses include firewood, dead and live fences, fodder, construction, supporting stakes, handcrafts, farming tools, extraction of tanning products, and medicine. There is no relationship between use and abundance. Alternative uses are proposed according to a density index. PMID:17354418

  4. Recreating the real, realizing the imaginary--a composer's preoccupation with acoustic space

    NASA Astrophysics Data System (ADS)

    Godman, Rob

    2002-11-01

    For centuries composers have been concerned with spatialization of sound and with the use of acoustic spaces to create feeling, atmosphere, and musical structure. This paper will explore Rob Godman's own use of sound in space, including (1) his treatment of ancient Vitruvian principles and how they are combined with new technologies; (2) an exploration of virtual journeys through real and imaginary acoustic spaces; (3) how sounds might be perceived in air, liquid, and solids; and (4) how technology has allowed composers to realize ideas that previously had only existed in the imagination. While focusing on artistic concerns, the paper will provide information on research carried out by the composer into acoustic spaces that are able to transform in real time with the aid of digital technology (Max/MSP software with sensor technology) and how these have been used in installation and pre-recorded work. It will also explore digital reconstructions of Vitruvian theatres and how we perceive resonance and ambience in the real and virtual world.

  5. Classification of underwater targets from autonomous underwater vehicle sampled bistatic acoustic scattered fields.

    PubMed

    Fischell, Erin M; Schmidt, Henrik

    2015-12-01

    One of the long term goals of autonomous underwater vehicle (AUV) minehunting is to have multiple inexpensive AUVs in a harbor autonomously classify hazards. Existing acoustic methods for target classification using AUV-based sensing, such as sidescan and synthetic aperture sonar, require an expensive payload on each outfitted vehicle and post-processing and/or image interpretation. A vehicle payload and machine learning classification methodology using bistatic angle dependence of target scattering amplitudes between a fixed acoustic source and target has been developed for onboard, fully autonomous classification with lower cost-per-vehicle. To achieve the high-quality, densely sampled three-dimensional (3D) bistatic scattering data required by this research, vehicle sampling behaviors and an acoustic payload for precision timed data acquisition with a 16 element nose array were demonstrated. 3D bistatic scattered field data were collected by an AUV around spherical and cylindrical targets insonified by a 7-9 kHz fixed source. The collected data were compared to simulated scattering models. Classification and confidence estimation were shown for the sphere versus cylinder case on the resulting real and simulated bistatic amplitude data. The final models were used for classification of simulated targets in real time in the LAMSS MOOS-IvP simulation package [M. Benjamin, H. Schmidt, P. Newman, and J. Leonard, J. Field Rob. 27, 834-875 (2010)].

  6. Incorporating human activities into an earth system model of the Northeastern United States: socio-hydrology at the regional scale

    NASA Astrophysics Data System (ADS)

    Rosenzweig, B.; Vorosmarty, C. J.; Miara, A.; Stewart, R.; Wollheim, W. M.; Lu, X.; Kicklighter, D. W.; Ehsani, N.; Shikhmacheva, K.; Yang, P.

    2013-12-01

    The Northeastern United States is one of the most urbanized regions of the world and its 70 million residents will be challenged by climate change as well as competing demands for land and water through the remainder of the 21st Century. The strategic management decisions made in the next few years will have major impacts on the region's future water resources, but planners have had limited quantitative information to support their decision-making. We have developed a Northeast Regional Earth System Model (NE-RESM), which allows for the testing of future scenarios of climate change, land use change and infrastructure management to better understand their implications for the region's water resources and ecosystem services. Human features of the water cycle - including thermoelectric power plants, wastewater treatment plants interbasin transfers and changes in impervious cover with different patterns of urban development - are explicitly represented in our modeling. We are currently engaged in a novel, participatory scenario design process with regional stakeholders to ensure the policy relevancy of our modeling experiments. The NE-RESM hydrologic modeling domain. Figure by Stanley Glidden and Rob Stewart

  7. Use and mis-use of supplementary material in science publications.

    PubMed

    Pop, Mihai; Salzberg, Steven L

    2015-11-03

    Supplementary material is a ubiquitous feature of scientific articles, particularly in journals that limit the length of the articles. While the judicious use of supplementary material can improve the readability of scientific articles, its excessive use threatens the scientific review process and by extension the integrity of the scientific literature. In many cases supplementary material today is so extensive that it is reviewed superficially or not at all. Furthermore, citations buried within supplementary files rob other scientists of recognition of their contribution to the scientific record. These issues are exacerbated by the lack of guidance on the use of supplementary information from the journals to authors and reviewers. We propose that the removal of artificial length restrictions plus the use of interactive features made possible by modern electronic media can help to alleviate these problems. Many journals, in fact, have already removed article length limitations (as is the case for BMC Bioinformatics and other BioMed Central journals). We hope that the issues raised in our article will encourage publishers and scientists to work together towards a better use of supplementary information in scientific publishing.

  8. Anthropic reasoning and typicality in multiverse cosmology and string theory

    NASA Astrophysics Data System (ADS)

    Weinstein, Steven

    2006-06-01

    Anthropic arguments in multiverse cosmology and string theory rely on the weak anthropic principle (WAP). We show that the principle is fundamentally ambiguous. It can be formulated in one of two ways, which we refer to as WAP1 and WAP2. We show that WAP2, the version most commonly used in anthropic reasoning, makes no physical predictions unless supplemented by a further assumption of 'typicality', and we argue that this assumption is both misguided and unjustified. WAP1, however, requires no such supplementation; it directly implies that any theory that assigns a non-zero probability to our universe predicts that we will observe our universe with probability one. We argue, therefore, that WAP1 is preferable, and note that it has the benefit of avoiding the inductive overreach characteristic of much anthropic reasoning. Thanks to Yuri Balashov, Gordon Belot, Rob Caldwell, Marcelo Gleiser, Brad Monton, Ken Olum, Jim Peebles, Lee Smolin and Alex Vilenkin for helpful discussions and comments on an earlier draft.

  9. Analysis of continuous GPS measurements from southern Victoria Land, Antarctica

    USGS Publications Warehouse

    Willis, Michael J.

    2007-01-01

    Several years of continuous data have been collected at remote bedrock Global Positioning System (GPS) sites in southern Victoria Land, Antarctica. Annual to sub-annual variations are observed in the position time-series. An atmospheric pressure loading (APL) effect is calculated from pressure field anomalies supplied by the European Centre for Medium-Range Weather Forecasts (ECMWF) model loading an elastic Earth model. The predicted APL signal has a moderate correlation with the vertical position time-series at McMurdo, Ross Island (International Global Navigation Satellite System Service (IGS) station MCM4), produced using a global solution. In contrast, a local solution in which MCM4 is the fiducial site generates a vertical time series for a remote site in Victoria Land (Cape Roberts, ROB4) which exhibits a low, inverse correlation with the predicted atmospheric pressure loading signal. If, in the future, known and well modeled geophysical loads can be separated from the time-series, then local hydrological loading, of interest for glaciological and climate applications, can potentially be extracted from the GPS time-series.

  10. Optimized Algorithms for Prediction Within Robotic Tele-Operative Interfaces

    NASA Technical Reports Server (NTRS)

    Martin, Rodney A.; Wheeler, Kevin R.; Allan, Mark B.; SunSpiral, Vytas

    2010-01-01

    Robonaut, the humanoid robot developed at the Dexterous Robotics Labo ratory at NASA Johnson Space Center serves as a testbed for human-rob ot collaboration research and development efforts. One of the recent efforts investigates how adjustable autonomy can provide for a safe a nd more effective completion of manipulation-based tasks. A predictiv e algorithm developed in previous work was deployed as part of a soft ware interface that can be used for long-distance tele-operation. In this work, Hidden Markov Models (HMM?s) were trained on data recorded during tele-operation of basic tasks. In this paper we provide the d etails of this algorithm, how to improve upon the methods via optimization, and also present viable alternatives to the original algorithmi c approach. We show that all of the algorithms presented can be optim ized to meet the specifications of the metrics shown as being useful for measuring the performance of the predictive methods. 1

  11. Ethnobotany and antibacterial activity of some plants used in traditional medicine of Zapotitlán de las Salinas, Puebla (México).

    PubMed

    Hernández, T; Canales, M; Avila, J G; Duran, A; Caballero, J; Romo de Vivar, A; Lira, R

    2003-10-01

    The village of Zapotitlán de las Salinas is situated in the Valley of Tehuacán-Cuicatlán, Puebla, Mexico. Plant species used by the local inhabitants to treat gastrointestinal diseases were identified using ethnobotanical, ethnographic and taxonomic methods. Out of 119 interviews, 44 plant species were registered, of which the following are the most frequently used (listed in descending order): Lippia graveolens H.B. et K. (Verbenaceae), Lantana achyranthifolia Desf. (Verbenaceae), Turnera diffusa (Willd.) ex Schult. (Turneraceae), Lippia oaxacana Rob. et Greenm. (Verbenaceae), Gymnolaena oaxacana (Greenm.) Rydb. (Asteraceae), Cordia curassavica (Jacq.) Roem. et Schult. (Boraginaceae), Lantana camara L. (Verbenaceae) and Acalypha hederacea Torrey (Euphorbiaceae). From these plants, hexane, chloroform and ethanol extracts were prepared in order to assess their antibacterial activity against 14 bacterial strains causing the most common gastrointestinal diseases in Mexican population. All hexane extracts showed antibacterial activity against Gram-positive and Gram-negative bacteria. There is a correlation between the frequency of mention (of plant use) and the antibacterial activity. In conclusion, the knowledge of plants most frequently used for gastrointestinal infections in Zapotitlán de las Salinas is supported by scientific rationale.

  12. Inception of cadaver dissection and its relevance in present day scenario of medical education.

    PubMed

    Rath, Gayatri; Garg, Krishna

    2006-06-01

    The concept of dissection for acquiring knowledge about the structure of human body was started in 15th century and barber--surgeons used to demonstrate various structures at the professors command. Andreas Vesalius (1514-1564) was the first medical student to dissect the cadaver and also continued with it even as a professor. Slowly and steadily its importance was realised. Once autopsy was accepted as a ideal parameter to establish the causes of death, the importance of dissection got enhanced. Cadavers were obtained earlier from the grave robbings and mortuaries, which was followed by, an Anatomy Act of 1832, by which unclaimed bodies were provided to the anatomy department. For last two decades, many persons started donating their bodies to the department of anatomy. In India, mostly unclaimed bodies are handed over to anatomy department for teaching and research purpose. Cadavers teach students during 1st professional course, autopsy teaches again in IInd and IIIrd professional courses and even later on throughout the career. Dissection helps in developing a spatial and tactile appreciation for the fabric of the human body that cannot be achieved by prosection or computerised learning aids alone. PMID:17058553

  13. 6th Dysferlin Conference, 3-6 April 2013, Arlington, Virginia, USA.

    PubMed

    Albrecht, Douglas E; Rufibach, Laura E; Williams, Bradley A; Lee, Elaine R; Windish, Hillarie P; Hwang, Esther Y; Shira, Sarah R; Mittal, Plavi

    2014-03-01

    The 2013 Dysferlin Conference, sponsored and organized by the Jain Foundation, was held from April 3-6, 2013 in Arlington, VA. Participants included 34 researcher speakers, 5 dysferlinopathy patients and all 8 members of the Jain Foundation team. Dysferlinopathy is a rare disease that typically robs patients of mobility during their second or third decade of life. The goals of these Dysferlin Conferences are to bring experts in the field together so that they will collaborate with one another, to quicken the pace of understanding the biology of the disease and to build effective platforms to ameliorate disease. This is important because the function of dysferlin and how to compensate for its absence is still not well understood, in spite of the fact that the dysferlin gene was identified more than a decade ago. The objective of this conference, therefore, was to share and discuss the newest unpublished research defining the role of dysferlin in skeletal muscle, why its absence causes muscular dystrophy and possible therapies for dysferlin-deficient muscular dystrophy patients.

  14. Colistin and tigecycline resistance in carbapenemase-producing Gram-negative bacteria: emerging resistance mechanisms and detection methods.

    PubMed

    Osei Sekyere, J; Govinden, U; Bester, L A; Essack, S Y

    2016-09-01

    A literature review was undertaken to ascertain the molecular basis for tigecycline and colistin resistance mechanisms and the experimental basis for the detection and delineation of this resistance particularly in carbapenemase-producing Gram-negative bacteria. Pubmed, Google Scholar and Science Direct were searched with the keywords colistin, tigecycline, resistance mechanisms and detection methods. Trans-complementation and comparative MIC studies, mass spectrometry, chromatography, spectrofluorometry, PCR, qRT-PCR and whole genome sequencing (WGS) were commonly used to determine tigecycline and colistin resistance mechanisms, specifically modifications in the structural and regulatory efflux (acrAB, OqxAB, kpgABC adeABC-FGH-IJK, mexAB-XY-oprJM and soxS, rarA robA, ramRAB marRABC, adeLRS, mexRZ and nfxb) and lipid A (pmrHFIJFKLM, lpxA, lpxC lpxD and mgrB, pmrAB, phoPQ,) genes respectively. Mutations in the ribosomal 16S rRNA operon rrnBC, also yielded resistance to tigecycline through target site modifications. The mcr-1 gene conferring resistance to colistin was identified via WGS, trans-complementation and a murine thigh infection model studies. Common detection methods are mainly antibiotic sensitivity testing with broth microdilution while molecular identification tools are mostly PCR and WGS. Spectrofluorometry, MALDI-TOF MS, micro-array and real-time multiplex PCR hold much promise for the future as new detection tools.

  15. Preliminary Thoughts on Introducing Structs to SIDL/Babel: White Paper

    SciTech Connect

    Epperly, T W

    2004-01-08

    In the past 6 months, there has been increased interest in adding something analogous to C structs to the SIDL language and the Babel language interoperability tool [2, 6]. In particular, Rob Armstrong, of the Common Component Architecture [4], said the lack of structs ''is an oft-cited reason that people can't use Babel.'' Because the interest is high and lack of structs is a barrier to Babel adoption, we must carefully consider the current work around, the motivations for structs, the implications of adding structs, and the alternatives for structs in SIDL/Babel. This document provides the background necessary for a discussion of structs in SIDL/Babel. For the purposes of this document, I am going to call the potential new language feature a SIDL struct. The SIDL struct is analogous to a C struct, a Pascal record, or a Fortran 90 (F90) derived data type. It is a collection of data with no methods or behavior associated with it. Each element of the collection has a name and a type. SIDL structs allow for data abstraction, but they do not provide data hiding. All data is public in a SIDL struct.

  16. Dynamic obstacle avoidance using Bayesian Occupancy Filter and approximate inference.

    PubMed

    Llamazares, Angel; Ivan, Vladimir; Molinos, Eduardo; Ocaña, Manuel; Vijayakumar, Sethu

    2013-01-01

    The goal of this paper is to solve the problem of dynamic obstacle avoidance for a mobile platform using the stochastic optimal control framework to compute paths that are optimal in terms of safety and energy efficiency under constraints. We propose a three-dimensional extension of the Bayesian Occupancy Filter (BOF) (Coué et al. Int. J. Rob. Res. 2006, 25, 19-30) to deal with the noise in the sensor data, improving the perception stage. We reduce the computational cost of the perception stage by estimating the velocity of each obstacle using optical flow tracking and blob filtering. While several obstacle avoidance systems have been presented in the literature addressing safety and optimality of the robot motion separately, we have applied the approximate inference framework to this problem to combine multiple goals, constraints and priors in a structured way. It is important to remark that the problem involves obstacles that can be moving, therefore classical techniques based on reactive control are not optimal from the point of view of energy consumption. Some experimental results, including comparisons against classical algorithms that highlight the advantages, are presented. PMID:23529117

  17. Striving to Reduce Vulnerability:Lessons from the Poor Community Livelihoodsin the Jakarta Bay Facing High Risk of Rapid Urbanization and Climate Changes

    NASA Astrophysics Data System (ADS)

    Hidayati, D.; Delinom, R. M.; Abdurachim, A. Y.; Dalimunthe, S.; Haba, J.; Pawitan, H.

    2014-12-01

    This paper discusses water-food issues in relation to how livelihoods of the poor community in Jakarta Bayarein high risk ofrapid urbanization and climate changes. As a part of the capital city of Indonesia, this area has experienced rapid increase in populationand extensive developments causing significant increase in the built up area. This city is unable to keep with demand on sewers, water and solid waste management, leading to settlement with concentrated slum pockets areas and widespread of flooding. The community is mostly poor people of productive group, live with urban pressure in fragile home and livelihoods.The situation becomes much worse due to the impact of climate change with flooding as the greatest climate and disaster risk. With lack of basic services, coastal water inundation (BanjirRob)commonly occursand floods the community housing areaswithout patternanymore. The community has lack of fresh and clean water sources and facedeconomic problem, particularly significant reduction of fishing activities. Coastal reclamation and water pollution from nearby industries are blamed as the main reason for these problems. Strategies therefore have to be developed, especially increasing community awareness and preparedness, and poverty alleviation, to sustain their livelihoods in this high risk urban area.

  18. Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking

    NASA Astrophysics Data System (ADS)

    Cua, Michelle; Lee, Sujin; Miao, Dongkai; Ju, Myeong Jin; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

    2016-02-01

    High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

  19. Astrometric observations of Phobos with the SRC on Mars Express. New data and comparison of different measurement techniques

    NASA Astrophysics Data System (ADS)

    Pasewaldt, A.; Oberst, J.; Willner, K.; Beisembin, B.; Hoffmann, H.; Matz, K. D.; Roatsch, T.; Michael, G.; Cardesín-Moinelo, A.; Zubarev, A. E.

    2015-08-01

    Aims: From April 2008 to August 2011 Mars Express carried out 74 Phobos flybys at distances between 669 and 5579 km. Images taken with the Super Resolution Channel (SRC) were used to determine the spacecraft-centered right ascension and declination of this Martian moon. Methods: Image positions of Phobos were measured using the limb-fit and control-point measurement techniques. Camera pointing and pointing drift were controlled by means of background star observations that were compared to corresponding positions from reference catalogs. Blurred and noisy images were restored by applying an image-based point spread function in a Richardson-Lucy deconvolution. Results: Here, we report on a set of 158 Phobos astrometric observations with estimated accuracies between 0.224 and 3.405 km circular w.r.t. the line of sight to the satellite. Control point measurements yield slightly more accurate results than the limb fit ones. Our observations are in good agreement with the current Phobos ephemerides by the Jet Propulsion Laboratory (JPL) and the Royal Observatory of Belgium (ROB) with mean offsets of up to 335 m. Our data can be used for the maintenance and update of these models. Tables A.1 and A.2 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/580/A28

  20. [Wolfgang Amadeus Mozart. A urological pathography].

    PubMed

    Hatzinger, M; Häcker, A; Langbein, S; Bross, S; Honeck, P; Alken, P

    2006-04-01

    The death of Wolfgang Amadeus Mozart was mysterious from the very first day, and cause of wildest speculation and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious death of Mozart with increasing intensity. By means of letters from his father Leopold, his sister "Nannerl", himself and reports from his physicians and contemporaries, we would like to create a medical pathography. The rumour that Mozart was poisoned appeared soon after his early death at the age of 35 on December 5th 1791, and was kept up persistently. Accused were the physician van Swieten, Mozart's freemason's loge and the royal band master Salieri. Mozart, however, died due to chronic kidney disease and ultimately due to uraemia. Once the renal damage has reached a certain point, a minimum of additional stress leads to decompensation. This catastrophe occurs typically within the fourth decade of life. When listening to Mozart's music, we should remember that this apparently happy person was actually a premature adult robbed of his childhood, whose short life was an endless chain of indisposition, over fatigue, misery, concern and illness.

  1. Three-month pattern of road traffic injuries at a Kenyan level 4 hospital.

    PubMed

    Matheka, Duncan Mwangangi; Kitonyi, Mercy Nzilani; Alkizim, Faraj Omar

    2015-01-01

    Road traffic injuries continue to exert a huge burden on the health care system in Kenya. Few studies on the pattern of road traffic injuries have been conducted in Kenya. We therefore carried out a retrospective study to determine the pattern of road traffic injuries seen in a public hospital in Naivasha district, Kenya. A retrospective study on surgical patients admitted at Naivasha District Hospital over a three month period was carried out. Eighty two percent of all patients injured in the crashes were men, and eighty percent were aged between 20-49 years. Most of the patients sustained lower limb injuries (41.5%) followed by head injuries (35.4%). Thirty one percent were pedestrians, 27.7% cyclists, 24.6% passengers and 16.9% motor vehicle drivers at the time of injury. Road traffic crashes are a growing pandemic, leading to high morbidity and mortality. Efforts need to be taken to prevent injuries, long term complications and loss of lives that are robbing communities off loved ones, bread winners and productive manpower.

  2. BeiDou Time Transfer With the Standard CGGTTS.

    PubMed

    Huang, Wei; Defraigne, Pascale

    2016-07-01

    The R2CGGTTS software tool developed at the Royal Observatory of Belgium (ROB) to provide clock solutions in the standard Common GNSS Generic Time Transfer Standard (CGGTTS) has been extended to BeiDou Navigation Satellite System (BDS). The BDS includes satellites in three different orbits: 1) Medium Earth Orbit (MEO); 2) Inclined Geosynchronous Satellite Orbit (IGSO); and 3) Geostationary Earth Orbit (GEO). This paper presents first results obtained with this upgraded software, and a comparison between common view (CV) time transfer solutions obtained with either BDS, or GPS or Galileo. These preliminary results indicate that the BeiDou MEO satellites give time transfer results with a higher noise than the GPS results. This additional noise is shown to be due to some elevation-dependent delay in the BDS code measurements. Some biases were furthermore pointed out between the CV results obtained with the different BeiDou MEO satellites when the receivers used in the two stations are of different make. These biases may reach some nanoseconds, and find most probably their origin in the receiver hardware or firmware. It is shown additionally that using the BeiDou IGSO satellites and the GEO satellites, although increasing the number of observations, especially in the Asia-Pacific region, introduces a significant time transfer noise in the CV results. PMID:26766373

  3. Molecular characterization of de novo secondary trisomy 13

    SciTech Connect

    Shaffer, L.G.; McCaskill, C.; Han, Jin-Yeong; Choo, K.H.A.; Cutillo, D.M.; Donnenfeld, A.E.; Weiss, L.; Van Dyke, D.L.

    1994-11-01

    Unbalanced Robertsonian translocations are a significant cause of mental retardation and fetal wastage. The majority of homologous rearrangements of chromosome 21 in Down syndrome have been shown to be isochromosomes. Aside from chromosome 21, very little is known about other acrocentric homologous rearrangements. In this study, four cases of de novo secondary trisomy 13 are presented. FISH using alpha-satellite sequences, rDNA, and a pTRI-6 satellite I sequence specific to the short arm of chromosome 13 showed all four rearrangements to be dicentric an apparently devoid of ribosomal genes. Three of four rearrangements retained the pTRI-6 satellite I sequence. Case 1 was the exception, showing a deletion of this sequence in the rearrangement, although both parental chromosomes 13 had strong positive hybridization signals. Eleven microsatellite markers from chromosome 13 were also used to characterize the rearrangements. Of the four possible outcomes, one maternal Robertsonian translocation, two paternal isochromosomes, and one maternal isochromosomes were observed. A double recombination was observed in the maternally derived rob(13q13q). No recombination events were detected in any isochromosome. The parental origins and molecular chromosomal structure of these cases are compared with previous studies of de novo acrocentric rearrangements. 20 refs., 3 figs., 2 tabs.

  4. Reproductive phenology and sharing of floral resource among hummingbirds (Trochilidae) in inflorescences of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae) in the Atlantic forest.

    PubMed

    Missagia, Caio C C; Verçoza, Fábio C; Alves, Maria Alice S

    2014-12-01

    The purpose of this study was to investigate the reproductive phenology and sharing of floral resource (nectar) of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae), endemic of Atlantic forest, among hummingbirds. For the phenology, we looked at the presence of reproductive structures in the plants, and for floral resource sharing, the frequency of potential pollinators and foraging behaviors were examined. This study was conducted in Pedra Branca State Park, in state of Rio de Janeiro, in a dense ombrophilous forest, between August 2010 and August 2011. Flowering occurred between December 2010 and March 2011, and fruiting between April and June 2011. Hummingbirds' foraging schedules differed significantly, with legitimate visits to the flowers occurring in the morning and illegitimate visits occurring during late morning and the afternoon. Five species visited flowers, three of which were legitimate visitors: Phaethornis ruber, P. pretrei, and Ramphodon naevius. Amazilia fimbriata and Thalurania glaucopis females only visited illegitimately. Phaethornis ruber robbed nectar (78% of illegitimate visits, n=337). Ramphodon naevius, with a territorial foraging behavior and a body size bigger than that of other observed hummingbird species, dominated the floral visits, which suggests that D. pinnata is an important nourishing resource for this endemic bird of the Atlantic forest, currently globally categorized as Near Threatened.

  5. Reproductive phenology and sharing of floral resource among hummingbirds (Trochilidae) in inflorescences of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae) in the Atlantic forest.

    PubMed

    Missagia, Caio C C; Verçoza, Fábio C; Alves, Maria Alice S

    2014-11-11

    The purpose of this study was to investigate the reproductive phenology and sharing of floral resource (nectar) of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae), endemic of Atlantic forest, among hummingbirds. For the phenology, we looked at the presence of reproductive structures in the plants, and for floral resource sharing, the frequency of potential pollinators and foraging behaviors were examined. This study was conducted in Pedra Branca State Park, in state of Rio de Janeiro, in a dense ombrophilous forest, between August 2010 and August 2011. Flowering occurred between December 2010 and March 2011, and fruiting between April and June 2011. Hummingbirds' foraging schedules differed significantly, with legitimate visits to the flowers occurring in the morning and illegitimate visits occurring during late morning and the afternoon. Five species visited flowers, three of which were legitimate visitors: Phaethornis ruber, P. pretrei, and Ramphodon naevius. Amazilia fimbriata and Thalurania glaucopis females only visited illegitimately. Phaethornis ruber robbed nectar (78% of illegitimate visits, n=337). Ramphodon naevius, with a territorial foraging behavior and a body size bigger than that of other observed hummingbird species, dominated the floral visits, which suggests that D. pinnata is an important nourishing resource for this endemic bird of the Atlantic forest, currently globally categorized as Near Threatened.

  6. Understanding the diversity of male clients of sex workers in China and the implications for HIV prevention programmes.

    PubMed

    Huang, Yingying; Maman, Suzanne; Pan, Suiming

    2012-01-01

    Male clients of sex workers have been overlooked in China's HIV prevention efforts. This study aims to examine men's practices and attitudes toward extramarital sexual relationships, motivations for visiting female sex workers (FSWs), perceptions of sexually transmitted infection (STI)/HIV risk and risk prevention strategies used. One hundred and eighty-six clients of FSWs with varying socio-economic statuses were interviewed in different sex work settings. Men described no conflict between their role as a client and a responsible family provider. They described social pressure from peers and business partners to visit FSWs, sexual pleasure and companionship as motivators to seek commercial sex. While some men reported no risks associated with visiting FSWs, others identified risks such as being arrested by the police, robbed by gangs and threatening the health of their families by contracting a STI. This study underscores the diversity of FSW clients and the need to understand the beliefs and behaviours of different client types to develop appropriate HIV prevention programmes. It also demonstrates the feasibility of recruiting different types of male clients, a hard-to-reach population for Chinese HIV prevention efforts.

  7. Sensor de orvalho/chuva aplicado à operação de telescópios

    NASA Astrophysics Data System (ADS)

    Raffaelli, J. C.; Neres, N. L.; Strauss, C.

    2003-08-01

    Foi desenvolvida uma estação meteorológica para o telescópio robótico Obelix do Observatório Abrahão de Moraes que inclui sensores de temperatura e umidade, além de um inédito sensor de orvalho e chuva que comanda o fechamento automático da cúpula caso haja perigo de condensação. Este sensor é composto de uma malha de segmentos metálicos próximos e detecta o aumento da condutividade do ar que precede a condensação. Esse método é mais confiável que o critério de 100% de umidade, que pode causar falsos alarmes devido a imprecisão dos sensores de umidade em geral e por não considerar a influência dos ventos que dificultam a condensação. O trabalho apresenta o método de construção desse sensor e os testes de avaliação. Sugere-se portanto a inclusão desse sensor nas estações meteorológicas dos telescópios do país.

  8. Lanthanide-thiophene-2,5-dicarboxylate frameworks: ionothermal synthesis, helical structures, photoluminescent properties, and single-crystal-to-single-crystal guest exchange.

    PubMed

    Zhan, Cai-Hong; Wang, Fei; Kang, Yao; Zhang, Jian

    2012-01-01

    Eight three-dimensional lanthanide-thiophene-2,5-dicarboxylate frameworks, [Ln(TDC)(2)]·(choline) (1-6; Ln = Gd, Nd, Eu, Er, Tb, Dy; TDC = thiophene-2,5-dicarboxylate), [Yb(TDC)(2)(e-urea)]·(choline)·H(2)O (7; e-urea = ethyleneurea), [Nd(2)(TDC)(3)(e-urea)(4)]·3(e-urea) (8) have been successfully prepared in deep eutectic solvents (choline chloride/e-urea), respectively. Compounds 1-7 are anionic frameworks with 8-connected bcu topology, while compound 8 features a neutral 6-connected rob-type framework with guest e-urea molecules. In these structures, lanthanide ions show dicapped trigonal prism, pentagonal bipyramid, and tricapped trigonal prism coordination configurations, respectively, and the TDC ligands exhibit different coordination modes. Versatile helical substructures are presented in these compounds. The photoluminescent properties of compounds 3 (Eu) and 8 (Nd) were studied. Moreover, compound 8 can perform single-crystal-to-single-crystal guest exchange. The ethanol-exchange mechanism of 8 can be ascribed to the kinetically controlled flexibility (KCF). PMID:22136232

  9. Dynamic Obstacle Avoidance Using Bayesian Occupancy Filter and Approximate Inference

    PubMed Central

    Llamazares, Ángel; Ivan, Vladimir; Molinos, Eduardo; Ocaña, Manuel; Vijayakumar, Sethu

    2013-01-01

    The goal of this paper is to solve the problem of dynamic obstacle avoidance for a mobile platform by using the stochastic optimal control framework to compute paths that are optimal in terms of safety and energy efficiency under constraints. We propose a three-dimensional extension of the Bayesian Occupancy Filter (BOF) (Coué et al. Int. J. Rob. Res. 2006, 25, 19–30) to deal with the noise in the sensor data, improving the perception stage. We reduce the computational cost of the perception stage by estimating the velocity of each obstacle using optical flow tracking and blob filtering. While several obstacle avoidance systems have been presented in the literature addressing safety and optimality of the robot motion separately, we have applied the approximate inference framework to this problem to combine multiple goals, constraints and priors in a structured way. It is important to remark that the problem involves obstacles that can be moving, therefore classical techniques based on reactive control are not optimal from the point of view of energy consumption. Some experimental results, including comparisons against classical algorithms that highlight the advantages are presented. PMID:23529117

  10. Sleeping Beauty: Kleine–Levin Syndrome

    PubMed Central

    Mudgal, Soumiya; Jiloha, R. C.; Kandpal, Manish; Das, Aparna

    2014-01-01

    Kleine–Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder. PMID:25316944

  11. Professional Ethics for Astronomers

    NASA Astrophysics Data System (ADS)

    Marvel, K. B.

    2005-05-01

    There is a growing recognition that professional ethics is an important topic for all professional scientists, especially physical scientists. Situations at the National Laboratories have dramatically proven this point. Professional ethics is usually only considered important for the health sciences and the legal and medical professions. However, certain aspects of the day to day work of professional astronomers can be impacted by ethical issues. Examples include refereeing scientific papers, serving on grant panels or telescope allocation committees, submitting grant proposals, providing proper references in publications, proposals or talks and even writing recommendation letters for job candidates or serving on search committees. This session will feature several speakers on a variety of topics and provide time for questions and answers from the audience. Confirmed speakers include: Kate Kirby, Director Institute for Theoretical Atomic and Molecular Physics - Professional Ethics in the Physical Sciences: An Overview Rob Kennicutt, Astrophysical Journal Editor - Ethical Issues for Publishing Astronomers Peggy Fischer, Office of the NSF Inspector General - Professional Ethics from the NSF Inspector General's Point of View

  12. Use and mis-use of supplementary material in science publications.

    PubMed

    Pop, Mihai; Salzberg, Steven L

    2015-01-01

    Supplementary material is a ubiquitous feature of scientific articles, particularly in journals that limit the length of the articles. While the judicious use of supplementary material can improve the readability of scientific articles, its excessive use threatens the scientific review process and by extension the integrity of the scientific literature. In many cases supplementary material today is so extensive that it is reviewed superficially or not at all. Furthermore, citations buried within supplementary files rob other scientists of recognition of their contribution to the scientific record. These issues are exacerbated by the lack of guidance on the use of supplementary information from the journals to authors and reviewers. We propose that the removal of artificial length restrictions plus the use of interactive features made possible by modern electronic media can help to alleviate these problems. Many journals, in fact, have already removed article length limitations (as is the case for BMC Bioinformatics and other BioMed Central journals). We hope that the issues raised in our article will encourage publishers and scientists to work together towards a better use of supplementary information in scientific publishing. PMID:26525146

  13. [Wolfgang Amadeus Mozart. A urological pathography].

    PubMed

    Hatzinger, M; Häcker, A; Langbein, S; Bross, S; Honeck, P; Alken, P

    2006-04-01

    The death of Wolfgang Amadeus Mozart was mysterious from the very first day, and cause of wildest speculation and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious death of Mozart with increasing intensity. By means of letters from his father Leopold, his sister "Nannerl", himself and reports from his physicians and contemporaries, we would like to create a medical pathography. The rumour that Mozart was poisoned appeared soon after his early death at the age of 35 on December 5th 1791, and was kept up persistently. Accused were the physician van Swieten, Mozart's freemason's loge and the royal band master Salieri. Mozart, however, died due to chronic kidney disease and ultimately due to uraemia. Once the renal damage has reached a certain point, a minimum of additional stress leads to decompensation. This catastrophe occurs typically within the fourth decade of life. When listening to Mozart's music, we should remember that this apparently happy person was actually a premature adult robbed of his childhood, whose short life was an endless chain of indisposition, over fatigue, misery, concern and illness. PMID:16369845

  14. Chlorogenic acid content, essential oil compositions, and in vitro antioxidant activities of Chromolaena odorata leaves

    PubMed Central

    Pitakpawasutthi, Yamon; Thitikornpong, Worathat; Palanuvej, Chanida; Ruangrungsi, Nijsiri

    2016-01-01

    Chromolaena odorata (L.) R. M. King and H. Rob. is a Thai medicinal plant used for the treatment of wounds, rashes, diabetes, and insect repellent. The leaves of C. odorata were collected from 10 different sources throughout Thailand. The chemical constituents of essential oils were hydro-distilled from the leaves and were analyzed by gas chromatography-mass spectrometry. Chlorogenic acid contents were determined by thin-layer chromatography (TLC) - densitometry with winCATS software and TLC image analysis with ImageJ software. The TLC plate was developed in the mobile phase that consisted of ethyl acetate:water:formic acid (17:3:2). Antioxidant activities were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging and β-carotene bleaching assays. C. odorata essential oil has shown the major components of pregeijerene, dauca-5, 8-diene, (E)-caryophyllene, β-pinene, and α-pinene. The chlorogenic acid content of C. odorata leaves was determined by TLC-densitometry and TLC image analysis. Results have shown that TLC-densitometry and TLC image analysis method were not statistically significantly different. DPPH radical scavenging and β-carotene bleaching assays of ethanolic extract of C. odorata leaves showed its antioxidant potential. PMID:27144150

  15. Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

    PubMed Central

    Li, Hui-qin; Wei, Jing-jing; Xia, Wan; Li, Ji-huang; Liu, Ai-ju; Yin, Su-bing; Wang, Chen; Song, Liang; Wang, Yan; Zheng, Guo-qing; Fan, Ji-ping

    2015-01-01

    Aim: To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis (PBCRBS) therapy for Chinese patients with acute intracerebral hemorrhage (ICH). Methods: Six databases were searched from their inception to November 2013. The studies assessed in ≥4 domains with 'yes' were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed. Results: From the 6 databases, 292 studies claimed randomized-controlled clinical trials (RCTs). Nine studies with 798 individuals were assessed in ≥4 domains with 'yes' by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs (danshen root, sanqi and leech) were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively. Conclusion: Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed. PMID:25960132

  16. Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

    PubMed Central

    Hobbs, Errett C.; Yin, Xuefeng; Paul, Brian J.; Astarita, Jillian L.; Storz, Gisela

    2012-01-01

    The AcrAB–TolC multidrug efflux pump confers resistance to a wide variety of antibiotics and other compounds in Escherichia coli. Here we show that AcrZ (formerly named YbhT), a 49-amino-acid inner membrane protein, associates with the AcrAB-TolC complex. Co-purification of AcrZ with AcrB, in the absence of both AcrA and TolC, two-hybrid assays and suppressor mutations indicate that this interaction occurs through the inner membrane protein AcrB. The highly conserved acrZ gene is coregulated with acrAB through induction by the MarA, Rob, and SoxS transcription regulators. In addition, mutants lacking AcrZ are sensitive to many, but not all, of the antibiotics transported by AcrAB–TolC. This differential antibiotic sensitivity suggests that AcrZ may enhance the ability of the AcrAB–TolC pump to export certain classes of substrates. PMID:23010927

  17. Ethnobotany and antibacterial activity of some plants used in traditional medicine of Zapotitlán de las Salinas, Puebla (México).

    PubMed

    Hernández, T; Canales, M; Avila, J G; Duran, A; Caballero, J; Romo de Vivar, A; Lira, R

    2003-10-01

    The village of Zapotitlán de las Salinas is situated in the Valley of Tehuacán-Cuicatlán, Puebla, Mexico. Plant species used by the local inhabitants to treat gastrointestinal diseases were identified using ethnobotanical, ethnographic and taxonomic methods. Out of 119 interviews, 44 plant species were registered, of which the following are the most frequently used (listed in descending order): Lippia graveolens H.B. et K. (Verbenaceae), Lantana achyranthifolia Desf. (Verbenaceae), Turnera diffusa (Willd.) ex Schult. (Turneraceae), Lippia oaxacana Rob. et Greenm. (Verbenaceae), Gymnolaena oaxacana (Greenm.) Rydb. (Asteraceae), Cordia curassavica (Jacq.) Roem. et Schult. (Boraginaceae), Lantana camara L. (Verbenaceae) and Acalypha hederacea Torrey (Euphorbiaceae). From these plants, hexane, chloroform and ethanol extracts were prepared in order to assess their antibacterial activity against 14 bacterial strains causing the most common gastrointestinal diseases in Mexican population. All hexane extracts showed antibacterial activity against Gram-positive and Gram-negative bacteria. There is a correlation between the frequency of mention (of plant use) and the antibacterial activity. In conclusion, the knowledge of plants most frequently used for gastrointestinal infections in Zapotitlán de las Salinas is supported by scientific rationale. PMID:12963140

  18. A Prejudiced Review of Ancient Parasites and Their Host Echinoderms: CSI Fossil Record or Just an Excuse for Speculation?

    PubMed

    Donovan, Stephen K

    2015-01-01

    Recognizing the presence of a parasite and identifying it is a relatively straightforward task for the twenty-first century parasitologist. Not so the pursuit of ancient parasites in fossil organisms, a much more difficult proposition. Herein, Boucot's seven-tiered scheme of reliability classes is applied as a measure of confidence of the recognition of putative parasitism in two echinoderm classes, Upper Palaeozoic crinoids and a Cretaceous echinoid (high confidence is 1, low confidence 7). Of the five examples, the parasitic(?) organism is preserved in only two of them. A zaphrentoid coral on the camerate crinoid Amphoracrinus may have robbed food from the arms (Category 1 or 2B). A pit in what appears to be a carefully selected site on the disparid crinoid Synbathocrinus is associated with a growth deformity of the cup (Category 4). Multiple pits in an Amphoracrinus theca are also associated with a deformed cup, but it is more difficult to interpret (Category 4 or 7). Some specimens of the camerate crinoid Neoplatycrinites have circular grooves or depressions posteriorly, presumably produced by coprophagic/parasitic platyceratid gastropods (Category 1). Site selectivity of pits in the echinoid Hemipneustes places them preferentially adjacent to respiratory tube feet (Category 4). From these examples it is deduced that sparse infestations of borings or epizoozoic organisms permit a more confident interpretation of organism/organism interactions; dense accumulations, possibly following multiple spatfalls, mask such patterns. PMID:26597070

  19. Highlights from Sherwood 2014. International Sherwood Fusion Theory Conference, March 24-26, Bahia Resort Hotel, San Diego, California

    SciTech Connect

    None, None

    2014-03-31

    Rob Goldston (PPPL) kicked off the Sherwood meeting with his review talk, “Understanding and innovation in magnetic fusion”. He covered a history of results from tokamak experiments in the areas of core confinement, stability, sustainment – tying the paradigms for understanding all three to the plasma edge, where outstanding questions remain. Two other review talks were given by Russel Caflisch (UCLA) on “Accelerated simulation of coulomb collisions in plasmas”, and Dan Barnes (Tri Alpha) on “Plasma theory as private enterprise”. Altogether, there were 15 invited talks spanning the field of fusion theory on topics such as nonlinear gyrokinetic simulations of the tokamak edge, plasma-wall modelling, toroidal rotation, zonal flows, magnetic field-line reconnection, coulomb collisions, and intrinsic momentum transport. Author-provided summaries of several of the invited talks are included on pages 7 to 14 of this document. There was a very strong showing by graduate students, postdocs, and young scientists at the meeting. More than 25 students from around the world presented papers. A list of all participating students can be found on page 5 of this document

  20. Early evolution of efficient enzymes and genome organization

    PubMed Central

    2012-01-01

    Background Cellular life with complex metabolism probably evolved during the reign of RNA, when it served as both information carrier and enzyme. Jensen proposed that enzymes of primordial cells possessed broad specificities: they were generalist. When and under what conditions could primordial metabolism run by generalist enzymes evolve to contemporary-type metabolism run by specific enzymes? Results Here we show by numerical simulation of an enzyme-catalyzed reaction chain that specialist enzymes spread after the invention of the chromosome because protocells harbouring unlinked genes maintain largely non-specific enzymes to reduce their assortment load. When genes are linked on chromosomes, high enzyme specificity evolves because it increases biomass production, also by reducing taxation by side reactions. Conclusion The constitution of the genetic system has a profound influence on the limits of metabolic efficiency. The major evolutionary transition to chromosomes is thus proven to be a prerequisite for a complex metabolism. Furthermore, the appearance of specific enzymes opens the door for the evolution of their regulation. Reviewers This article was reviewed by Sándor Pongor, Gáspár Jékely, and Rob Knight. PMID:23114029

  1. Multiple mechanisms underlie displacement of solitary Hawaiian Hymenoptera by an invasive social wasp.

    PubMed

    Wilson, E E; Holway, D A

    2010-11-01

    Variation in invasion success may result from the divergent evolutionary histories of introduced species compared to those of native taxa. The vulnerability of native biotas to ecological disruption may be especially great on oceanic islands invaded by continental species with unique ecological traits. In part because Hawaii lacks native eusocial insects, social invaders may threaten endemic taxa that are ecologically similar but solitary. Using a combination of field manipulations, molecular analyses, physiological data, and behavioral assays, we identify the mechanisms underlying the displacement of two genera of native solitary Hymenoptera in Hawaii by a social continental invader, the western yellowjacket (Vespula pensylvanica). Experimental removal of V. pensylvanica colonies resulted in increased densities of native Hymenoptera. Endemic Hylaeus bees directly suffer through predation by yellowjackets, and perhaps as a consequence, avoid floral resources occupied by V. pensylvanica. Native Nesodynerus wasps also avoid V. pensylvanica but are negatively affected by yellowjackets not through predation, but through exploitative competition for caterpillar prey. Displacement of native solitary Hymenoptera may be heightened by the ability of V. pensylvanica to prey upon and scavenge honey bees and to rob their honey stores, resources unavailable to endemic bees and wasps because of their specialized niches. Our study provides a unique example of an ecologically generalized social invader that restructures native assemblages of solitary Hymenoptera by interacting with endemic taxa on multiple trophic levels. PMID:21141190

  2. Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis.

    PubMed

    Li, Ling; Qu, Ye; Jin, Xin; Guo, Xiao Qin; Wang, Yue; Qi, Lin; Yang, Jing; Zhang, Peng; Li, Ling Zhi

    2016-01-01

    Hypoxia-inducible factor (HIF)-1α plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo. Our results showed that pre-treatment with SAL markedly attenuated the hypoxia-induced reductions in cell viability, apoptosis, differentiation and mineralization. SAL down-regulated HIF-1α expression and inhibited its translocation; however, SAL increased its transcriptional activity and, consequently, up-regulated vascular endothelial growth factor (VEGF). In vivo studies further demonstrated that SAL caused decreases in the mineral, alkaline phosphatase (ALP), and BGP concentrations in the blood of ovariectomized (OVX) rats. Moreover, SAL improved the trabecular bone microarchitecture and increased bone mineral density in the distal femur. Additionally, SAL administration partially ameliorated this hypoxia via the HIF-1α-VEGF signalling pathway. Our results indicate that SAL prevents bone loss by enhancing angiogenesis and osteogenesis and that these effects are associated with the activation of HIF-1α signalling. PMID:27558909

  3. Phylogenomic study of spiral-horned antelope by cross-species chromosome painting.

    PubMed

    Rubes, Jiri; Kubickova, Svatava; Pagacova, Eva; Cernohorska, Halina; Di Berardino, Dino; Antoninova, Marketa; Vahala, Jiri; Robinson, Terence J

    2008-01-01

    Chromosomal homologies have been established between cattle (Bos taurus, 2n = 60) and eight species of spiral-horned antelope, Tribe Tragelaphini: Nyala (Tragelaphus angasii, 2n = 55male/56female), Lesser kudu (T. imberbis, 2n = 38male,female), Bongo (T. eurycerus, 2n = 33male/34female), Bushbuck (T. scriptus, 2n = 33male/34female), Greater kudu (T. strepsiceros, 2n = 31male/32female), Sitatunga (T. spekei, 2n = 30male,female) Derby eland (Taurotragus derbianus 2n = 31male/32female) and Common eland (T. oryx 2n = 31male/32female). Chromosomes involved in centric fusions in these species were identified using a complete set of cattle painting probes generated by laser microdissection. Our data support the monophyly of Tragelaphini and a clade comprising T. scriptus, T. spekei, T. euryceros and the eland species T. oryx and T. derbianus, findings that are largely in agreement with sequence-based molecular phylogenies. In contrast, our study suggests that the arid adaptiveness of T. oryx and T. derbianus is recent. Finally, we have identified the presence of the rob(1;29) fusion as an evolutionary marker in most of the tragelaphid species investigated. This rearrangement is associated with reproductive impairment in cattle and raises questions whether subtle distinctions in breakpoint location or differential rescue during meiosis underpin the different outcomes detected among these lineages. PMID:18704723

  4. Successful demonstration of a compact laser-pumped vector helium magnetometer on the Daytime Dynamo sounding rockets

    NASA Astrophysics Data System (ADS)

    Murphy, N.; Angelopoulos, V.; Pierce, D.; Dawson, O.; Bernal, I.; Leinweber, H. K.; Shaffer, C.; Plaschke, F.; Raymond, C. A.; Pfaff, R. F.; Rowland, D. E.

    2013-12-01

    The Daytime Dynamo sounding rocket mission is a Goddard Space Flight Center led experiment (PI, Rob Pfaff) to study the dayside ionospheric dynamo with a suite of instruments that measure electromagnetic fields, upper atmospheric winds, and the ambient charged and neutral particle populations. Two Dynamo launches have taken place, the first on July 10th, 2011, the second on July 4th 2013. The primary objective of the mission is to determine the constituents of the dynamo current equation and to determine the degree to which the dynamo current is sustained via neutral winds, DC electric fields, or both. Dynamo carries a magnetometer developed by a JPL/UCLA collaboration that measures the vector magnetic field, and from its variation with altitude, allows us to deduce the horizontal current density. The low-mass instrument uses a laser pumped helium sensor developed at JPL, combined with digital electronics based on recent developments in fluxgate magnetometer electronics at UCLA. We will present an overview of the magnetometer design and the instrument performance.

  5. Official crime data versus collaborative crime mapping at a Brazilian city

    NASA Astrophysics Data System (ADS)

    Brito, P. L.; Jesus, E. G. V.; Sant'Ana, R. M. S.; Martins, C.; Delgado, J. P. M.; Fernandes, V. O.

    2014-11-01

    In July of 2013 a group of undergraduate students from the Federal University of Bahia, Brazil, published a collaborative web map called "Where I Was Robbed". Their initial efforts in publicizing their web map were restricted to announce it at a local radio as a tool of social interest. In two months the map had almost 10.000 reports, 155 reports per day and people from more the 350 cities had already reported a crime. The present study consists in an investigation about this collaborative web map spatial correlation to official robbery data registered at the Secretary of Public Safety database, for the city of Salvador, Bahia. Kernel density estimator combined with map algebra was used to the investigation. Spatial correlations with official robbery data for the city of Salvador were not found initially, but after standardizing collaborative data and mining official registers, both data pointed at very similar areas as the main hot spots for pedestrian robbery. Both areas are located at two of the most economical active areas of the city, although web map crimes reports were more concentrated in an area with higher income population. This results and discussions indicates that this collaborative application is been used mainly by mid class and upper class parcel of the city population, but can still provide significant information on public safety priority areas. Therefore, extended divulgation, on local papers, radio and TV, of the collaborative crime map application and partnership with official agencies are strongly recommended.

  6. A nurse clinician's approach to knife crime prevention.

    PubMed

    England, Rachel; Jackson, Rob

    This article outlines a new and creative contribution to knife crime prevention by an emergency nurse clinician and an initial evaluation of its effectiveness. The 'knife crime prevention programme' is delivered to young people aged 11-16 years by one of the authors, Rob Jackson, an emergency nurse clinician at Liverpool University Hospital; the aim is to educate young people about the medical consequences of knife injury. A group of 140 students and 17 teachers responded to a questionnaire evaluating the effectiveness of the session delivered to four schools in Liverpool. Students and teachers positively rated the session, with the combination of the nurse clinician's knowledge and expertise and photographs and depictions of knife crime as a unique and impacting approach to knife crime prevention. It is suggested that the nurse clinician and other experienced health professionals have an important contribution to make in preventive approaches to knife crime. Further evaluation of the knife crime prevention programme will be conducted by the authors.

  7. FGF8 regulates myogenesis and induces Runx2 expression and osteoblast differentiation in cultured cells.

    PubMed

    Omoteyama, Kazuki; Takagi, Minoru

    2009-03-01

    In the current study, treatment of the rat osteogenic cell line ROB-C26 cells with fibroblast growth factor 8 (FGF8) stimulated alkaline phosphatase (ALP) activity, and also induced the expression of the Runx2 transcription factor, and increased the activity of a luciferase reporter gene containing the osteocalcin (OCN) promoter and six copies of the osteoblast specific cis-acting element 2 (OSE2) response element. In contrast, FGF8 treatment of the mouse myoblast cell line C2C12 inhibited the expression of desmin and the synthesis of myotubes. The expression of MyoD, Myogenin, Foxc2, and Hand1 was also decreased by FGF8. Transient expression of Foxc2 in C2C12 cells induced the expression of Hand1, and chromatin immunoprecipitation (ChIP) analysis indicated that Foxc2 binds to the promoter region of the Hand1 gene. These results indicated that Foxc2 is directly involved in the regulation of Hand1 expression. The results of the current study indicate that FGF8 regulates myoblast differentiation through the regulation of MyoD expression, and that this regulation is independent of Hand1 in cultured cells. Conversely, FGF8 supports bone development and cell differentiation though the induction of Runx2 expression.

  8. Precision instrument placement using a 4-DOF robot with integrated fiducials for minimally invasive interventions

    NASA Astrophysics Data System (ADS)

    Stenzel, Roland; Lin, Ralph; Cheng, Peng; Kronreif, Gernot; Kornfeld, Martin; Lindisch, David; Wood, Bradford J.; Viswanathan, Anand; Cleary, Kevin

    2007-03-01

    Minimally invasive procedures are increasingly attractive to patients and medical personnel because they can reduce operative trauma, recovery times, and overall costs. However, during these procedures, the physician has a very limited view of the interventional field and the exact position of surgical instruments. We present an image-guided platform for precision placement of surgical instruments based upon a small four degree-of-freedom robot (B-RobII; ARC Seibersdorf Research GmbH, Vienna, Austria). This platform includes a custom instrument guide with an integrated spiral fiducial pattern as the robot's end-effector, and it uses intra-operative computed tomography (CT) to register the robot to the patient directly before the intervention. The physician can then use a graphical user interface (GUI) to select a path for percutaneous access, and the robot will automatically align the instrument guide along this path. Potential anatomical targets include the liver, kidney, prostate, and spine. This paper describes the robotic platform, workflow, software, and algorithms used by the system. To demonstrate the algorithmic accuracy and suitability of the custom instrument guide, we also present results from experiments as well as estimates of the maximum error between target and instrument tip.

  9. Nestling diets and provisioning rates of sympatric Golden-fronted and Ladder-backed Woodpeckers

    USGS Publications Warehouse

    Schroeder, Evonne L.; Boal, Clint W.; Glasscock, Selma N.

    2013-01-01

    We examined comparative food use and provisioning of Golden-fronted (Melanerpes aurifrons) and Ladder-backed (Picoides scalaris) woodpeckers at the Rob and Bessie Welder Wildlife Foundation Refuge, in San Patricio County, Texas. We combined video surveillance and direct observations to monitor provisioning rates and identify items delivered by adult woodpeckers to nestlings. We collected 328 hours of data at Ladder-backed Woodpecker nest cavities and 230 hours of data at Golden-fronted Woodpecker nest cavities. Ladder-backed Woodpecker nestling diets consisted of 100% animal matter, comprised of invertebrate larvae (99%) and invertebrate adults (< 1%). Diets of Golden-fronted Woodpecker nestlings were also high in animal matter (77%) with more invertebrate adults (55%) and fewer invertebrate larvae (27%), but also included vegetable matter (16%). Morisita's measure of overlap suggested a relatively low dietary overlap of 31% between nestlings of these two sympatric woodpecker species. Foraging methods used by these species may explain their low dietary overlap and facilitate their coexistence.

  10. Microbial infections in a declining wild turkey population in Texas (USA)

    USGS Publications Warehouse

    Rocke, T.E.; Yuill, Thomas M.

    1987-01-01

    A survey was conducted at 5 locations in Texas for avian pathogens that might adversely affect wild turkey (Meleagris gallopavo) productivity and survival. At 1 site, the Rob and Bessie Welder Wildlife Refuge (WWR), turkeys have declined precipitously in recent years. During the winters of 1983-85, 442 wild turkeys were caught with cannon and drop nets, 161 of these on WWR. Blood samples were drawn for serologic evaluation, and cloacal and tracheal swabs were collected for isolation attempts. Salmonella spp. bacteria, Newcastle disease virus (NDV), and avian influenza virus (AIV) were not detected in any samples tested. Serologic tests for antibodies to NDV and AIV also were negative. Many mycoplasma isolates were recovered from turkeys from every location. Characterization of these isolates indicated that several species were present. None were species typically associated with mycoplasmosis in domestic turkeys, such as Mycoplasma gallisepticum (MG), M. meleagridis (MM), or M. synoviae (MS), although antibodies to these pathogens were detected in turkeys at every location sampled. There was no evidence to link any of these disease causing agents to the decline observed in the population of wild turkeys on the WWR.

  11. Understanding the diversity of male clients of sex workers in China and the implications for HIV prevention programmes.

    PubMed

    Huang, Yingying; Maman, Suzanne; Pan, Suiming

    2012-01-01

    Male clients of sex workers have been overlooked in China's HIV prevention efforts. This study aims to examine men's practices and attitudes toward extramarital sexual relationships, motivations for visiting female sex workers (FSWs), perceptions of sexually transmitted infection (STI)/HIV risk and risk prevention strategies used. One hundred and eighty-six clients of FSWs with varying socio-economic statuses were interviewed in different sex work settings. Men described no conflict between their role as a client and a responsible family provider. They described social pressure from peers and business partners to visit FSWs, sexual pleasure and companionship as motivators to seek commercial sex. While some men reported no risks associated with visiting FSWs, others identified risks such as being arrested by the police, robbed by gangs and threatening the health of their families by contracting a STI. This study underscores the diversity of FSW clients and the need to understand the beliefs and behaviours of different client types to develop appropriate HIV prevention programmes. It also demonstrates the feasibility of recruiting different types of male clients, a hard-to-reach population for Chinese HIV prevention efforts. PMID:22313090

  12. Salerno, saints, and Sutton's Law: on the origin of Europe's "First" medical school.

    PubMed

    Duffin, Jacalyn

    2009-08-01

    When the famous bank robber, Willie Sutton was asked why he robbed banks, he replied, ''Because that's where the money is'' The Salerno school is often described as the first European school of medicine. Many scholars have offered theories to account for its origins, including the idea that it is merely a historical "construct" and not a school at all. This paper proposes another hypothesis based on a juxtaposition of primary sources, secondary literature, and observations of religious worship in the Salerno region. An extraordinary number of sites sacred to the memory of doctor saints dot the coastal promontory near Salerno. This concentration of medical saints might be explained by the church catering to a populace aware of the secular healing tradition in nearby Salerno. But if the saints came with or even before the school, both church and medicine could be seen as responding to a preexisting local need. Sutton's Law points to another hypothesis. Famous for its climate, gardens, and natural beauty, the coast served as a health resort since at least the time of ancient Rome. As a result, sick people with resources have long traveled to the region in search of comfort and cures. Saints and doctors followed the sick (and their money). PMID:19356856

  13. Reproductive phenology and sharing of floral resource among hummingbirds (Trochilidae) in inflorescences of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae) in the Atlantic forest.

    PubMed

    Missagia, Caio C C; Verçoza, Fábio C; Alves, Maria Alice S

    2014-11-11

    The purpose of this study was to investigate the reproductive phenology and sharing of floral resource (nectar) of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae), endemic of Atlantic forest, among hummingbirds. For the phenology, we looked at the presence of reproductive structures in the plants, and for floral resource sharing, the frequency of potential pollinators and foraging behaviors were examined. This study was conducted in Pedra Branca State Park, in state of Rio de Janeiro, in a dense ombrophilous forest, between August 2010 and August 2011. Flowering occurred between December 2010 and March 2011, and fruiting between April and June 2011. Hummingbirds' foraging schedules differed significantly, with legitimate visits to the flowers occurring in the morning and illegitimate visits occurring during late morning and the afternoon. Five species visited flowers, three of which were legitimate visitors: Phaethornis ruber, P. pretrei, and Ramphodon naevius. Amazilia fimbriata and Thalurania glaucopis females only visited illegitimately. Phaethornis ruber robbed nectar (78% of illegitimate visits, n=337). Ramphodon naevius, with a territorial foraging behavior and a body size bigger than that of other observed hummingbird species, dominated the floral visits, which suggests that D. pinnata is an important nourishing resource for this endemic bird of the Atlantic forest, currently globally categorized as Near Threatened. PMID:25387391

  14. Reproductive phenology and sharing of floral resource among hummingbirds (Trochilidae) in inflorescences of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae) in the Atlantic forest.

    PubMed

    Missagia, Caio C C; Verçoza, Fábio C; Alves, Maria Alice S

    2014-12-01

    The purpose of this study was to investigate the reproductive phenology and sharing of floral resource (nectar) of Dahlstedtia pinnata (Benth.) Malme. (Fabaceae), endemic of Atlantic forest, among hummingbirds. For the phenology, we looked at the presence of reproductive structures in the plants, and for floral resource sharing, the frequency of potential pollinators and foraging behaviors were examined. This study was conducted in Pedra Branca State Park, in state of Rio de Janeiro, in a dense ombrophilous forest, between August 2010 and August 2011. Flowering occurred between December 2010 and March 2011, and fruiting between April and June 2011. Hummingbirds' foraging schedules differed significantly, with legitimate visits to the flowers occurring in the morning and illegitimate visits occurring during late morning and the afternoon. Five species visited flowers, three of which were legitimate visitors: Phaethornis ruber, P. pretrei, and Ramphodon naevius. Amazilia fimbriata and Thalurania glaucopis females only visited illegitimately. Phaethornis ruber robbed nectar (78% of illegitimate visits, n=337). Ramphodon naevius, with a territorial foraging behavior and a body size bigger than that of other observed hummingbird species, dominated the floral visits, which suggests that D. pinnata is an important nourishing resource for this endemic bird of the Atlantic forest, currently globally categorized as Near Threatened. PMID:25590708

  15. "What do these women want?": Feminist responses to Feminine Forever, 1963-1980.

    PubMed

    Houck, Judith A

    2003-01-01

    In 1963, Brooklyn gynecologist Robert A. Wilson and his wife, Thelma, published a paper in the Journal of the American Geriatrics Society arguing that untreated menopause robbed women of their femininity and ruined the quality of their lives. In 1966 Robert Wilson published a best-selling book, Feminine Forever, in which he maintained that menopause was an estrogen-deficiency disease that should be treated with estrogen replacement therapy to prevent the otherwise inevitable "living decay." This paper explores the issues raised by the convergence of Wilson's campaign and the emergence of the women's movement. Between 1963 and 1980, feminists did not respond with one voice to Wilson's ideas: at first, some embraced them as a boon for aging women, while others resisted regarding female aging as pathological. In 1975, studies linking ERT and endometrial cancer challenged the wisdom of routine hormone therapy; this shifted the tenor of the feminist discussion, but it did not create a consensus about the meaning of menopause or its treatment. Nevertheless, the feminist discussion of menopause revealed a larger women's health agenda-namely, the unyielding belief that women should retain control of their bodies and participate fully in the decision-making efforts regarding their health. By controlling their bodies, all women, whether feminist or not, could ultimately control their lives. PMID:12649555

  16. Concerns about eroding the ethical barrier to in vitro eugenics: lessons from the hESC debate.

    PubMed

    Pugh, Jonathan

    2014-11-01

    In his discussion of in vitrogametogenesis, Rob Sparrow claims that an ethical barrier to development of this technology is that many jurisdictions currently prohibit the practice of creating embryos solely for the purpose of research. However, he suggests that this ethical barrier will soon be eroded, in view of the fact that in vitro gametogenesis could serve as a powerful new technology to overcome infertility. In this commentary, I argue that Sparrow is being overly optimistic in his analysis here. I claim that the debate over so-called compromise positions in the human embryonic stem cell debate suggests that the purpose of the research for which a research embryo is created is unlikely to be considered as having any significant bearing on the moral permissibility of the practice for those who oppose it. Even though in vitro gametogenesis could serve as a powerful new technology to overcome infertility, I argue that opponents of the practice of creating embryos solely for research purposes would still view the creation of research embryos that the development of in vitro gametogenesis would require, as being incompatible with affording the embryo proper moral respect. I conclude by suggesting that Sparrow's analysis of the potential benefits of in vitro gametogenesis provides us with further reasons to scrutinise the unconvincing arguments that are often cited in favour of prohibiting the practice of creating embryos solely for research purposes.

  17. Global network alignment using multiscale spectral signatures

    PubMed Central

    Patro, Rob; Kingsford, Carl

    2012-01-01

    Motivation: Protein interaction networks provide an important system-level view of biological processes. One of the fundamental problems in biological network analysis is the global alignment of a pair of networks, which puts the proteins of one network into correspondence with the proteins of another network in a manner that conserves their interactions while respecting other evidence of their homology. By providing a mapping between the networks of different species, alignments can be used to inform hypotheses about the functions of unannotated proteins, the existence of unobserved interactions, the evolutionary divergence between the two species and the evolution of complexes and pathways. Results: We introduce GHOST, a global pairwise network aligner that uses a novel spectral signature to measure topological similarity between subnetworks. It combines a seed-and-extend global alignment phase with a local search procedure and exceeds state-of-the-art performance on several network alignment tasks. We show that the spectral signature used by GHOST is highly discriminative, whereas the alignments it produces are also robust to experimental noise. When compared with other recent approaches, we find that GHOST is able to recover larger and more biologically significant, shared subnetworks between species. Availability: An efficient and parallelized implementation of GHOST, released under the Apache 2.0 license, is available at http://cbcb.umd.edu/kingsford_group/ghost Contact: rob@cs.umd.edu PMID:23047556

  18. Accounting for personhood in palliative sedation: the Ring Theory of Personhood.

    PubMed

    Radha Krishna, Lalit Kumar

    2014-06-01

    Application of sedation at the end of life has been fraught with ethical and clinical concerns, primarily focused on its potential to hasten death. However, in the face of clinical data that assuage most of these concerns, a new threat to this treatment of last resort has arisen. Concern now pivots on its effects on the personhood of the patient, underpinned by the manner in which personhood has been conceptualised. For many authors, it is consciousness that is seen to be the seat of personhood, thus its loss is seen to rob a patient of their moral and ethical worth, leaving them in a state that cannot ethically be differentiated from death. Here I proffer a clinically based alternative to this view, the Ring Theory of Personhood, which dispels these concerns about sedation at the end of life. The Ring Theory envisages personhood as a coadunation of three domains of concern: the innate, the individual and the relational elements of personhood. The innate element of personhood is held to be present among all humans by virtue of their links with the Divine and or their human characteristics. The individual elements of personhood pivot on the presence of consciousness-dependent features such as self-awareness, self-determination and personality traits. The relational component of personhood envisages an individual as being 'socially embedded' replete with social and familial ties. It is these three equally important inter-related domains that define personhood.

  19. Seismic Response of a Deep Underground Geologic Repository for Nuclear Waste at the Waste Isolation Pilot Plant in New Mexico

    SciTech Connect

    Sanchez, P.E.

    1998-11-02

    The Waste Isolation Pilot Plant (WIPP) is a deep underground nuclear waste repository certified by the U.S. Environmental Protection Agency ,(EPA) to store transuranic defense-related waste contaminated by small amounts of radioactive materials. Located at a depth of about 655 meters below the surface, the facility is sited in southeastern New Mexico, about 40 Department of Energy underground facilities, waste disposal. kilometers east of the city of Carlsbad, New Mexico. The U.S. (DOE) managed the design and construction of the surface and and remains responsible for operation and closure following The managing and operating contractor for the DOE at the WIPP, Westinghouse Electric Corporation, maintains two rechmiant seismic monitoring systems located at the surface and in the underground. This report discusses two earthquakes detected by the seismic monitoring system, one a duratior magnitude 5.0 (Md) event located approximately 60 km east-southeast of the facility, and another a body-wave magnitude 5.6 (rob) event that occurred approximately 260 kilometers to the south-southeast.

  20. Lateralized Kinematics of Predation Behavior in a Lake Tanganyika Scale-Eating Cichlid Fish

    PubMed Central

    Takeuchi, Yuichi; Hori, Michio; Oda, Yoichi

    2012-01-01

    Behavioral lateralization has been documented in many vertebrates. The scale-eating cichlid fish Perissodus microlepis is well known for exhibiting lateral dimorphism in its mouth morphology and lateralized behavior in robbing scales from prey fish. A previous field study indicated that this mouth asymmetry closely correlates with the side on which prey is attacked, but details of this species' predation behavior have not been previously analyzed because of the rapidity of the movements. Here, we studied scale-eating behavior in cichlids in a tank through high-speed video monitoring and quantitative assessment of behavioral laterality and kinematics. The fish observed showed a clear bias toward striking on one side, which closely correlated with their asymmetric mouth morphologies. Furthermore, the maximum angular velocity and amplitude of body flexion were significantly larger during attacks on the preferred side compared to those on the nonpreferred side, permitting increased predation success. In contrast, no such lateral difference in movement elements was observed in acoustically evoked flexion during the escape response, which is similar to flexion during scale eating and suggests that they share a common motor control pathway. Thus the neuronal circuits controlling body flexion during scale eating may be functionally lateralized upstream of this common motor pathway. PMID:22238598

  1. The Use of Arabidopsis to Study Interactions between Parasitic Angiosperms and Their Plant Hosts

    PubMed Central

    Goldwasser, Y.; Westwood, J. H.; Yoder, J. I.

    2002-01-01

    Parasitic plants invade host plants in order to rob them of water, minerals and nutrients. The consequences to the infected hosts can be debilitating and some of the world's most pernicious agricultural weeds are parasitic. Parasitic genera of the Scrophulariaceae and Orobanchaceae directly invade roots of neighboring plants via underground structures called haustoria. The mechanisms by which these parasites identify and associate with host plants present unsurpassed opportunities for studying chemical signaling in plant-plant interactions. Seeds of some parasites require specific host factors for efficient germination, thereby insuring the availability of an appropriate host root prior to germination. A second set of signal molecules is required to induce haustorium development and the beginning of heterotrophy. Later stages in parasitism also require the presence of host factors, although these have not yet been well characterized. Arabidopsis is being used as a model host plant to identify genetic loci associated with stimulating parasite germination, haustorium development, and parasite support. Arabidopsis is also being employed to explore how host plants respond to parasite attack. Current methodologies and recent findings in Arabidopsis – parasitic plant interactions will be discussed. PMID:22303205

  2. Chlorogenic acid content, essential oil compositions, and in vitro antioxidant activities of Chromolaena odorata leaves.

    PubMed

    Pitakpawasutthi, Yamon; Thitikornpong, Worathat; Palanuvej, Chanida; Ruangrungsi, Nijsiri

    2016-01-01

    Chromolaena odorata (L.) R. M. King and H. Rob. is a Thai medicinal plant used for the treatment of wounds, rashes, diabetes, and insect repellent. The leaves of C. odorata were collected from 10 different sources throughout Thailand. The chemical constituents of essential oils were hydro-distilled from the leaves and were analyzed by gas chromatography-mass spectrometry. Chlorogenic acid contents were determined by thin-layer chromatography (TLC) - densitometry with winCATS software and TLC image analysis with ImageJ software. The TLC plate was developed in the mobile phase that consisted of ethyl acetate:water:formic acid (17:3:2). Antioxidant activities were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging and β-carotene bleaching assays. C. odorata essential oil has shown the major components of pregeijerene, dauca-5, 8-diene, (E)-caryophyllene, β-pinene, and α-pinene. The chlorogenic acid content of C. odorata leaves was determined by TLC-densitometry and TLC image analysis. Results have shown that TLC-densitometry and TLC image analysis method were not statistically significantly different. DPPH radical scavenging and β-carotene bleaching assays of ethanolic extract of C. odorata leaves showed its antioxidant potential. PMID:27144150

  3. The impact of phloem nutrients on overwintering mountain pine beetles and their fungal symbionts.

    PubMed

    Goodsman, Devin W; Erbilgin, Nadir; Lieffers, Victor J

    2012-06-01

    In the low nutrient environment of conifer bark, subcortical beetles often carry symbiotic fungi that concentrate nutrients in host tissues. Although bark beetles are known to benefit from these symbioses, whether this is because they survive better in nutrient-rich phloem is unknown. After manipulating phloem nutrition by fertilizing lodgepole pine trees (Pinus contorta Douglas var. latifolia), we found bolts from fertilized trees to contain more living individuals, and especially more pupae and teneral adults than bolts from unfertilized trees at our southern site. At our northern site, we found that a larger proportion of mountain pine beetle (Dendroctonus ponderosae Hopkins) larvae built pupal chambers in bolts from fertilized trees than in bolts from unfertilized trees. The symbiotic fungi of the mountain pine beetle also responded to fertilization. Two mutualistic fungi of bark beetles, Grosmannia clavigera (Rob.-Jeffr. & R. W. Davidson) Zipfel, Z. W. de Beer, & M. J. Wingf. and Leptographium longiclavatum Lee, S., J. J. Kim, & C. Breuil, doubled the nitrogen concentrations near the point of infection in the phloem of fertilized trees. These fungi were less capable of concentrating nitrogen in unfertilized trees. Thus, the fungal symbionts of mountain pine beetle enhance phloem nutrition and likely mediate the beneficial effects of fertilization on the survival and development of mountain pine beetle larvae.

  4. Recent activities of the FP7-ESPaCE consortium

    NASA Astrophysics Data System (ADS)

    Thuillot, W.; Lainey, V.; Dehant, V.; Arlot, J.-E.; Gurvits, , L.; Hussmann, H.; Oberst, J.; Rosenblatt, P.; Marty, J. C.; Vermeersen, B.; Bauer, S.; De Cuyper, J.-P.; Dirkx, D.; Hestroffer, D.; Kudryashova, M.; Meunier, L. E.; Pasewaldt, A.; Rambaux, N.; Robert, V.; Tajeddine, R.; Willner, K.

    2014-12-01

    The consortium ESPaCE (European Satellite Partnership for Computing Ephemerides) is composed of seven European institutes: IMCCE ((Institut de Mécanique Céleste et de Calcul des Ephémérides, Paris Obs.), ROB (Royal Observatory of Belgium), TUB (Technical University of Berlin), JIVE (Joint Institute for VLBI in Europe), TUD (Delft University of Technology), French space agency (CNES) in France and German Aerospace Center (DLR) in Germany. The objective of this FP7 European project is to provide new accurate ephemerides of natural satellites and spacecraft. For this goal many astrometric data issued from ground-based observations as well as from space observations have been analyzed and reduced. On the other hand new technologies applied to the positioning of spacecraft are also studied. The ESPaCE project addresses also data related to gravity and shape modeling, control point network and rotational parameters of natural satellites. The accuracy improvement of these ephemerides makes them a powerful tool for the analysis of space missions or the preparation of future missions, or for the determination of some physical parameters.

  5. Light Microsopy Module, International Space Station Premier Automated Microscope

    NASA Technical Reports Server (NTRS)

    Meyer, William V.; Sicker, Ronald J.; Chiaramonte, Francis P.; Brown, Daniel F.; O'Toole, Martin A.; Foster, William M.; Motil, Brian J.; Abbot-Hearn, Amber Ashley; Atherton, Arthur Johnson; Beltram, Alexander; Bozioney, Christopher M.; Brinkman, John Michael; Chestney, Louis S.; Czernec, Richard P.; Dial, William B.; Dombrosky, Deena M.; Eustace, John G.; Reid, Ryan James; Reinke, Sharon A.; Rogers, Christopher R.; Samrani, Joseph T.; Shumway, Steven Scott; Smith, Teresa Ann; Stroh, James R.; Storck, Jennifer L.; Werner, Christopher Raymond; Wilkinson, Myron A.; Zoldak, John T.; Grant, Nechelle M.; Loucks, Brian C.; Plastow, Richard A.; Pestak, Mark W.; Fletcher, William A.

    2015-01-01

    The Light Microscopy Module (LMM) was launched to the International Space Station (ISS) in 2009 and began science operations in 2010. It continues to support Physical and Biological scientific research on ISS. During 2015, if all goes as planned, five experiments will be completed: [1] Advanced Colloids Experiments with a manual sample base -3 (ACE-M-3), [2] the Advanced Colloids Experiment with a Heated Base -1 (ACE-H-1), [3] (ACE-H-2), [4] the Advanced Plant Experiment -03 (APEX-03), and [5] the Microchannel Diffusion Experiment (MDE). Preliminary results, along with an overview of present and future LMM capabilities will be presented; this includes details on the planned data imaging processing and storage system, along with the confocal upgrade to the core microscope. [1] New York University: Paul Chaikin, Andrew Hollingsworth, and Stefano Sacanna, [2] University of Pennsylvania: Arjun Yodh and Matthew Gratale, [3] a consortium of universities from the State of Kentucky working through the Experimental Program to Stimulate Competitive Research (EPSCoR): Stuart Williams, Gerold Willing, Hemali Rathnayake, et al., [4] from the University of Florida and CASIS: Anna-Lisa Paul and Rob Ferl, and [5] from the Methodist Hospital Research Institute from CASIS: Alessandro Grattoni and Giancarlo Canavese.

  6. Model of Transcriptional Activation By MarA in Escherichia Coli

    NASA Astrophysics Data System (ADS)

    Wall, Michael E.; Markowitz, David A.; Rosner, Judah L.; Martin, Robert G.

    2010-01-01

    We have developed a mathematical model of transcriptional activation by MarA in Escherichia coli, and used the model to analyze measurements of MarA-dependent activity of the marRAB, sodA, and micF promoters in mar-rob- cells. The model rationalizes an unexpected poor correlation between the mid-point of in vivo promoter activity profiles and in vitro equilibrium constants for MarA binding to promoter sequences. Analysis of the promoter activity data using the model yielded the following predictions regarding activation mechanisms: (1) MarA activation of the marRAB, sodA, and micF promoters involves a net acceleration of the kinetics of transitions after RNA polymerase binding, up to and including promoter escape and message elongation; (2) RNA polymerase binds to these promoters with nearly unit occupancy in the absence of MarA, making recruitment of polymerase an insignificant factor in activation of these promoters; and (3) instead of recruitment, activation of the micF promoter might involve a repulsion of polymerase combined with a large acceleration of the kinetics of polymerase activity. These predictions are consistent with published chromatin immunoprecipitation assays of interactions between polymerase and the E. coli chromosome. A lack of recruitment in transcriptional activation represents an exception to the textbook description of activation of bacterial sigma-70 promoters. However, use of accelerated polymerase kinetics instead of recruitment might confer a competitive advantage to E. coli by decreasing latency in gene regulation.

  7. Secondary stem anatomy and uses of four drought-deciduous species of a tropical dry forest in México.

    PubMed

    Isaias, Alejandra Quintanar; Velázquez Núñez, Mariana; Solares Arenas, Fortunato; de la Paz Pérez Olvera, Carmen; Torre-Blanco, Alfonso

    2005-01-01

    Wood and bark anatomy and histochemistry of Acacia bilimekii Humb. & Bonpl., Acacia cochliacantha Mcbride, Conzatia nultiflora (Rob) Stand. and Guazuma ulmifolia Lam. are described from stem samples collected in a tropical dry forest (Morelos, Mexico). Enzyme activities were tested in tangential, radial and transverse cuts of fresh material. Histochemistry and stem anatomy were studied on similar cuts previously softened in a solution of water-glicerol-PEG. Our results show that the anatomical patterns of bark and wood, as well as the histochemical patterns and specific gravity, are influenced by water accessibility and climate; these patterns could guarantee mechanical and anti-infection strategies to support extreme conditions. Enzyme cytochemistry reveals biochemical activities probably related to lipid utilization routes for the lignification processes and for synthesis of extractives; these results suggest that the formation and maturation of woody tissue is very active at the beginning of the rainy season. These species are widely used by the local population. Traditional uses include firewood, dead and live fences, fodder, construction, supporting stakes, handcrafts, farming tools, extraction of tanning products, and medicine. There is no relationship between use and abundance. Alternative uses are proposed according to a density index.

  8. Word Meaning Frequencies Affect Negative Compatibility Effects In Masked Priming

    PubMed Central

    Brocher, Andreas; Koenig, Jean-Pierre

    2016-01-01

    Negative compatibility effects (NCEs)—that is, slower responses to targets in related than unrelated prime-target pairs, have been observed in studies using stimulus-response (S-R) priming with stimuli like arrows and plus signs. Although there is no consensus on the underlying mechanism, explanations tend to locate NCEs within the motor-response system. A characteristic property of perceptuo-motor NCEs is a biphasic pattern of activation: A brief period in which very briefly presented (typically) masked primes facilitate processing of related targets is followed by a phase of target processing impairment. In this paper, we present data that suggest that NCEs are not restricted to S-R priming with low-level visual stimuli: The brief (50 ms), backward masked (250 ms) presentation of ambiguous words (bank) leads to slower responses than baseline to words related to the more frequent (rob) but not less frequent meaning (swim). Importantly, we found that slowed responses are preceded by a short phase of response facilitation, replicating the biphasic pattern reported for arrows and plus signs. The biphasic pattern of priming and the fact that the NCEs were found only for target words that are related to their prime word’s more frequent meaning has strong implications for any theory of NCEs that locate these effects exclusively within the motor-response system. PMID:27152129

  9. [The problem of durable resistance of plants to different pests].

    PubMed

    Odintsova, I G; Radchenko, E E; Tyryshkin, L G

    2002-01-01

    Different hypotheses concerning durable plant resistance against different pest were tested: 1) resistance is weak and polygenetically controlled; 2) resistance depends on "residual effect" of oligogenes that were overcome by pests. Contrast pair of plants and pests were used in experiments: wheat, barley--facultative parasite Bipolaris sorokiniana Shoem., wheat--obligate parasite Puccinia recondita Rob. ex Desm., sorghum--greenbug Schizaphis graminum Rond. Differential interaction between parasite and host plant resulted in their increased compatibility under long reproduction of parasite on resistant varieties were regarded as criteria of quick overcoming of resistance. The results did not support any hypothesis. The rate of adaptation of B. sorokiniana to the resistant varieties of wheat and barley did not depend on the level of resistance expression (weak, moderate or strong) and genetic control (oligogenic, polygenic or cytoplasmatic). It was shown by hybridological analysis that "residual effect" of oligogenes of sorghum resistance against greenbug depended on small resistance genes, that can be independent or weakly connected with marker oligogene. These data allows to doubt in phenomenon of "residual effect" of oligogenes. It was shown that non specific pathogenicity of parasitic fungi increased during their reproductions on sensitive varieties of plants. Thus, cultivation of sensitive varieties causes damage of crop culture non only because of their own losses, but also by increasing the infection of moderately resistant varieties.

  10. Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis

    PubMed Central

    Li, Ling; Qu, Ye; Jin, Xin; Guo, Xiao Qin; Wang, Yue; Qi, Lin; Yang, Jing; Zhang, Peng; Li, Ling Zhi

    2016-01-01

    Hypoxia-inducible factor (HIF)-1α plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo. Our results showed that pre-treatment with SAL markedly attenuated the hypoxia-induced reductions in cell viability, apoptosis, differentiation and mineralization. SAL down-regulated HIF-1α expression and inhibited its translocation; however, SAL increased its transcriptional activity and, consequently, up-regulated vascular endothelial growth factor (VEGF). In vivo studies further demonstrated that SAL caused decreases in the mineral, alkaline phosphatase (ALP), and BGP concentrations in the blood of ovariectomized (OVX) rats. Moreover, SAL improved the trabecular bone microarchitecture and increased bone mineral density in the distal femur. Additionally, SAL administration partially ameliorated this hypoxia via the HIF-1α-VEGF signalling pathway. Our results indicate that SAL prevents bone loss by enhancing angiogenesis and osteogenesis and that these effects are associated with the activation of HIF-1α signalling. PMID:27558909

  11. Classification of underwater targets from autonomous underwater vehicle sampled bistatic acoustic scattered fields.

    PubMed

    Fischell, Erin M; Schmidt, Henrik

    2015-12-01

    One of the long term goals of autonomous underwater vehicle (AUV) minehunting is to have multiple inexpensive AUVs in a harbor autonomously classify hazards. Existing acoustic methods for target classification using AUV-based sensing, such as sidescan and synthetic aperture sonar, require an expensive payload on each outfitted vehicle and post-processing and/or image interpretation. A vehicle payload and machine learning classification methodology using bistatic angle dependence of target scattering amplitudes between a fixed acoustic source and target has been developed for onboard, fully autonomous classification with lower cost-per-vehicle. To achieve the high-quality, densely sampled three-dimensional (3D) bistatic scattering data required by this research, vehicle sampling behaviors and an acoustic payload for precision timed data acquisition with a 16 element nose array were demonstrated. 3D bistatic scattered field data were collected by an AUV around spherical and cylindrical targets insonified by a 7-9 kHz fixed source. The collected data were compared to simulated scattering models. Classification and confidence estimation were shown for the sphere versus cylinder case on the resulting real and simulated bistatic amplitude data. The final models were used for classification of simulated targets in real time in the LAMSS MOOS-IvP simulation package [M. Benjamin, H. Schmidt, P. Newman, and J. Leonard, J. Field Rob. 27, 834-875 (2010)]. PMID:26723332

  12. Computer animation of Phanerozoic plate motions

    SciTech Connect

    Scotese, C.R. . Dept. of Geology)

    1992-01-01

    Since 1985, the PALEOMAP Project, in collaboration with research groups both in the US and abroad, has assembled a digital model that describes global plate motions during the last 600 million years. In this paper the authors present a series of computer animations that dynamically illustrates the movement of continents and terranes, and the evolution of the ocean basins since the breakup of the late Precambrian supercontinent. These animations depict the motion of the plates from both equatorial and polar perspectives. Mesozoic and Cenozoic plate tectonic reconstructions are based on a synthesis of linear magnetic anomalies, fracture zone locations, intracontinental rifts, collision and thrust belts, and zones of strike-slip. Paleozoic plate reconstructions, though more speculative, are based on evidence of past subduction, continental collision, and inferred sea floor spreading. The relative longitudinal positions of the continents during the Paleozoic and the width of intervening oceans have been adjusted to best explain changing biogeographic and paleoclimatic patterns. A new paleomagnetic/hot spot reference frame has been constructed that combines paleomagnetic data compiled by Rob Van der Voo (1992) with inferred motion relative to a fixed frame of hot spots. Using probable Early Mesozoic and Paleozoic hot spot tracks on the major continents, the authors have extended plate motions relative to the hot spot reference frame back to 400 million years.

  13. Sampling and Complementarity Effects of Plant Diversity on Resource Use Increases the Invasion Resistance of Communities

    PubMed Central

    Zhu, Dan H.; Wang, Ping; Zhang, Wei Z.; Yuan, Yue; Li, Bin; Wang, Jiang

    2015-01-01

    Background Although plant diversity is postulated to resist invasion, studies have not provided consistent results, most of which were ascribed to the influences of other covariate environmental factors. Methodology/Principal Findings To explore the mechanisms by which plant diversity influences community invasibility, an experiment was conducted involving grassland sites varying in their species richness (one, two, four, eight, and sixteen species). Light interception efficiency and soil resources (total N, total P, and water content) were measured. The number of species, biomass, and the number of seedlings of the invading species decreased significantly with species richness. The presence of Patrinia scabiosaefolia Fisch. ex Trev. and Mosla dianthera (Buch.-Ham. ex Roxburgh) Maxim. significantly increased the resistance of the communities to invasion. A structural equation model showed that the richness of planted species had no direct and significant effect on invasion. Light interception efficiency had a negative effect on the invasion whereas soil water content had a positive effect. In monocultures, Antenoron filiforme (Thunb.) Rob. et Vaut. showed the highest light interception efficiency and P. scabiosaefolia recorded the lowest soil water content. With increased planted-species richness, a greater percentage of pots showed light use efficiency higher than that of A. filiforme and a lower soil water content than that in P. scabiosaefolia. Conclusions/Significance The results of this study suggest that plant diversity confers resistance to invasion, which is mainly ascribed to the sampling effect of particular species and the complementarity effect among species on resources use. PMID:26556713

  14. Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard

    PubMed Central

    Esse, Katherine; Fossati-Bellani, Marco; Traylor, Angela; Martin-Schild, Sheryl

    2011-01-01

    Drug abuse robs individuals of their jobs, their families, and their free will as they succumb to addiction; but may cost even more: a life of disability or even life lost due to stroke. Many illicit drugs have been linked to major cardiovascular events and other comorbidities, including cocaine, amphetamines, ecstasy, heroin, phencyclidine, lysergic acid diethylamide, and marijuana. This review focuses on available epidemiological data, mechanisms of action, particularly those leading to cerebrovascular events, and it is based on papers published in English in PubMed during 1950 through February 2011. Each drug's unique interactions with the brain and vasculature predispose even young, healthy people to ischemic or hemorrhagic stroke. Cocaine and amphetamines have the strongest association with stroke. However, the level of evidence firmly linking other drugs to stroke pathogenesis is weak. Large epidemiological studies and systematic evaluation of each drug's action on the brain and cardiovascular system are needed to reveal the full impact of drug use on the population. PMID:22398980

  15. A new reduction of Astrometric Photographic Plates using the DAMIAN Digitizer

    NASA Astrophysics Data System (ADS)

    Robert, Vincent; De Cuyper, J.; Arlot, J.; Lainey, V.; Pascu, D.

    2010-05-01

    A new astrometric reduction of old photographic plates that benefits from modern technologies can provide a better knowledge of the orbital motion of planetary satellites. In that respect, an international collaboration has been set up between the USNO, the OBSPM and the ROB to digitize USNO plates with the new generation scanning machine. The procedure can be applied to various photographic plates and it is assumed that the astrometric results will be the most precise. Here we consider a set of a few hundred photographic plates of the Galilean satellites, taken at the USNO, and covering the years 1967-1998. A specific procedure was developed to obtain a high accuracy in the position of each moon. So far, 30 plates were digitized at the Paris Observatory with the MAMA machine (2006 and 2007) and the complete series is now being digitized at the Brussels Observatory with the new DAMIAN machine. The first results suggest an accuracy better than 50 mas in (RA,Dec) positions of each moon. Since the position of Jupiter may also be deduced from the observed Ra and Dec positions of the satellites, using the Galilean satellite ephemerides, we can also assess the accuracy of Jupiter's ephemeris. First astrometric results will be presented.

  16. Administration of Reconstituted Polyphenol Oil Bodies Efficiently Suppresses Dendritic Cell Inflammatory Pathways and Acute Intestinal Inflammation

    PubMed Central

    Cavalcanti, Elisabetta; Vadrucci, Elisa; Delvecchio, Francesca Romana; Addabbo, Francesco; Bettini, Simona; Liou, Rachel; Monsurrò, Vladia; Huang, Alex Yee-Chen; Pizarro, Theresa Torres

    2014-01-01

    Polyphenols are natural compounds capable of interfering with the inflammatory pathways of several in vitro model systems. In this study, we developed a stable and effective strategy to administer polyphenols to treat in vivo models of acute intestinal inflammation. The in vitro suppressive properties of several polyphenols were first tested and compared for dendritic cells (DCs) production of inflammatory cytokines. A combination of the polyphenols, quercetin and piperine, were then encapsulated into reconstituted oil bodies (OBs) in order to increase their stability. Our results showed that administration of low dose reconstituted polyphenol OBs inhibited LPS-mediated inflammatory cytokine secretion, including IL-6, IL-23, and IL-12, while increasing IL-10 and IL-1Rα production. Mice treated with the polyphenol-containing reconstituted OBs (ROBs) were partially protected from dextran sodium sulfate (DSS)-induced colitis and associated weight loss, while mortality and inflammatory scores revealed an overall anti-inflammatory effect that was likely mediated by impaired DC immune responses. Our study indicates that the administration of reconstituted quercetin and piperine-containing OBs may represent an effective and potent anti-inflammatory strategy to treat acute intestinal inflammation. PMID:24558444

  17. Kermesite, Sb2S2O: crystal structure revision and order-disorder interpretation.

    PubMed

    Hybler, Jiří; Durovič, Slavomil

    2013-12-01

    Kermesite, Sb2S2O, is a desymmetrized order-disorder (OD) structure of layers. Two data sets were recorded using twinned crystals from Pezinok, Slovakia (named as Pz21, Pz24). The primitive unit cell is triclinic, P1, Z = 4, cell parameters are a = 8.1416 (3), b = 10.6968 (3), c = 5.7835 (2) Å, α = 102.758 (3), β = 110.657 (3), γ = 101.020 (3)°, R(obs) = 0.0243 (Pz21), and a = 8.1372 (2), b = 10.6969 (2), c = 5.7840 (1) Å, α = 102.787 (2), β = 110.606 (2), γ = 100.983 (2)°, R(obs) = 0.0321 (Pz24). The structure can also be described in the non-standard pseudo-monoclinic octuple (Z = 32), F-centered (Kupčík) cell with extra points in 1/4,1/4,0; 1/4,3/4,1/2; 3/4,1/4,1/2; 3/4,3/4,0, with parameters a = 21.6466 (9), b = 8.1416 (3), c = 20.3824 (9) Å, α = 90.079 (4), β = 101.985 (5), γ = 89.948 (4)° (Pz21), and a = 21.6558 (5), b = 8.1372 (2), c = 20.3859 (8) Å, α = 90.028 (3), β = 101.994 (3), γ = 89.986 (2)° (Pz24). The structure is built of layers parallel to the bc plane, stacked along the a vector of the octuple cell, composed of ribbons parallel to the b vector: (i) ribbon of two strips of SbO5 flattened quadrangular pyramids, sharing apical edges; (ii) ribbon of edge-sharing corrugated lozenges SbO3S. Basal S atoms of pyramids share corners of lozenges. Sb atoms are displaced out of coordination polyhedra into the inter-layer space. The OD layer comprises adjacent halves of the structure building layers. The layer group is A(1)2/m1, the protocell is defined by b, c, (a/4)sin β. The MDO1 (4A) polytype is generated by repetition of the t(1,1/4,0) [or alternatively t(1,-1/4,0)] translation. The co-existence of two kinds of domains give rise to the twinning. The twin operation is 2[010], twin index 2. The total continuation of [. a2 .] generates the MDO2 (2M) polytype, space group A12/a1. Simulated and real diffraction patterns are presented. The important values (edges, angles) and

  18. Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH receptor binding, and TRH responses in neurons of rat brainstem.

    PubMed

    Bayliss, D A; Viana, F; Kanter, R K; Szymeczek-Seay, C L; Berger, A J; Millhorn, D E

    1994-02-01

    We investigated the postnatal development of the thyrotropin-releasing hormone (TRH)-containing raphe system in the brainstem of neonatal rats. Postnatal changes in TRH expression in nucleus (n.) raphe obscurus (ROb) and n. raphe pallidus (RPa) were evaluated by in situ hybridization using an 35S-labeled oligonucleotide probe complementary to TRH precursor mRNA. TRH mRNA expression was low at birth [postnatal day 0 (P0)], but was clearly evident by P7 and increased from that time to reach sustained high levels from P14 to P28. Consistent with this postnatal increase in TRH expression, we found increases in the density of TRH-immunoreactive (IR) fibers, which are derived from ROb and RPa, in the hypoglossal nucleus (nXII). TRH-IR fibers in nXII were very sparse at P0, but increased markedly over the first 2 postnatal weeks. The change in TRH innervation of nXII was closely matched by concomitant increases in 3H-methyl-TRH binding in nXII; specific TRH binding increased from very low levels at birth to high levels of P14. Finally, we recorded intracellularly the electrophysiological responses to TRH of hypoglossal motoneurons (HMs; n = 42) of neonatal rats (P0-P21) in a brainstem slice preparation. The response of neonatal HMs to TRH, in contrast to adult HMs, was highly variable. In some neonatal HMs, even at P0, TRH caused a depolarization with a decrease in input conductance (GN) that was characteristic of the response of all adult HMs. However, in other neonatal HMs, TRH was either without effect or caused a slight depolarization with no apparent change in GN, responses that were unlike those of adult HMs. A response was considered typical (i.e., "adult-like") if GN decreased to < 85% of control. The percentage of cells responding in a typical manner increased progressively from 25% at P0-P2 to 100% after P11. In addition, we found that the density of TRH-sensitive current (normalized to cell capacitance) increased with postnatal age in HMs that responded in a

  19. The ESA Virtual Space Weather Modelling Centre - Phase 1

    NASA Astrophysics Data System (ADS)

    Poedts, Stefaan

    The ESA ITT project (AO/1-6738/11/NL/AT) to develop Phase 1 of a Virtual Space Weather Modelling Centre has the following objectives and scope: 1. The construction of a long term (~10 yrs) plan for the future development of a European virtual space weather modelling centre consisting of a new ‘open’ and distributed framework for the coupling of physics based models for space weather phenomena; 2. The assessment of model capabilities and the amount of work required to make them operational by integrating them in this framework and the identification of computing and networking requirements to do so. 3. The design of a system to enable models and other components to be installed locally or geographically distributed and the creation of a validation plan including a system of metrics for testing results. The consortium that took up this challenge involves: 1)the Katholieke Universiteit Leuven (Prime Contractor, coordinator: Prof. S. Poedts); 2) the Belgian Institute for Space Aeronomy (BIRA-IASB); 3) the Royal Observatory of Belgium (ROB); 4) the Von Karman Institute (VKI); 5) DH Consultancy (DHC); 6) Space Applications Services (SAS). The project started on May 14 2012, and will finish in May 2014. Thus, by the time of the meeting, both Phase 1A and Phase 1B (the development of the prototype) will be finished. The final report will be presented incl. the architecture decisions made, the framework, the current models integrated already as well as the model couplers installed. The prototype VSWMC will be demonstrated.

  20. Detection of the under-soil intruder activity

    NASA Astrophysics Data System (ADS)

    Cechak, Jaroslav

    2007-04-01

    The presented paper focuses on the possibilities of technical methods designed to detect a trespasser under the ground, and in general on the possibilities of detection a trespasser behind an obstruction. The paper analyses method of detection of a trespasser that were practically verified by the author of the paper. The first part of the paper discusses the characteristics and use of piezoelectric films that could be used as a replacement for the traditional geophone for detection of underground mining operation. It also provides a block connection diagram of the measuring chain and photos of the practical implementation of the sensor. The consequent part of the paper then discusses the possibilities of detecting a trespasser based on electromagnetic waves emission by humans in the ELF - Extremely Low Frequency band. The paper is supplemented with illustrative photos and results of numeric processing of signals in the form of graphs and courses. The history of excavating and using tunnels spans long into the past. Tunnels were used not only as storage for food and war material but mainly as effective means of protection against attackers. A significant motivating factor for constructing tunnels lies in the hidden possibility of movement of people and transfer of material under the ground of a protected perimeter. At present some tunnels are used as roads for smuggling drugs, weapons, ammunition or illegal passages of people. There are even cases, not exceptional, when tunnels were excavated with the aim to rob a bank safe etc. The fact that construction of tunnels, often quite primitive ones, is not sporadic, can be continually documented not only by historical sources but often also by the daily news summary. The concurrent lack of proper technological means results in the renaissance of using tunnels for illegal purposes even at present. The presented paper focuses on the above mentioned area and points to little used physical principles of detection underground

  1. Does Plant Origin Influence the Fitness Impact of Flower Damage? A Meta-Analysis.

    PubMed

    González-Browne, Catalina; Murúa, Maureen M; Navarro, Luis; Medel, Rodrigo

    2016-01-01

    Herbivory has been long considered an important component of plant-animal interactions that influences the success of invasive species in novel habitats. One of the most important hypotheses linking herbivory and invasion processes is the enemy-release hypothesis, in which exotic plants are hypothesized to suffer less herbivory and fitness-costs in their novel ranges as they leave behind their enemies in the original range. Most evidence, however, comes from studies on leaf herbivory, and the importance of flower herbivory for the invasion process remains largely unknown. Here we present the results of a meta-analysis of the impact of flower herbivory on plant reproductive success, using as moderators the type of damage caused by floral herbivores and the residence status of the plant species. We found 51 papers that fulfilled our criteria. We also included 60 records from unpublished data of the laboratory, gathering a total of 143 case studies. The effects of florivory and nectar robbing were both negative on plant fitness. The methodology employed in studies of flower herbivory influenced substantially the outcome of flower damage. Experiments using natural herbivory imposed a higher fitness cost than simulated herbivory, such as clipping and petal removal, indicating that studies using artificial herbivory as surrogates of natural herbivory underestimate the real fitness impact of flower herbivory. Although the fitness cost of floral herbivory was high both in native and exotic plant species, floral herbivores had a three-fold stronger fitness impact on exotic than native plants, contravening a critical element of the enemy-release hypothesis. Our results suggest a critical but largely unrecognized role of floral herbivores in preventing the spread of introduced species into newly colonized areas.

  2. Sex inequality, high transport costs, and exposed clinic location: reasons for loss to follow-up of clients under prevention of mother-to-child HIV transmission in eastern Uganda – a qualitative study

    PubMed Central

    Lubega, Muhamadi; Musenze, Ibrahim A; Joshua, Gukiina; Dhafa, George; Badaza, Rose; Bakwesegha, Christopher J; Reynolds, Steven J

    2013-01-01

    Background In Iganga, Uganda, 45% of women who tested HIV-positive during antenatal care between 2007 and 2010 were lost to follow-up (LTFU). We explored reasons for LTFU during prevention of mother-to-child transmission (PMTCT) from a client perspective in eastern Uganda, where antiretroviral therapy (ART) awareness is presumably high. Methods Seven key informant interviews and 20 in-depth interviews, including both clients who had been retained under PMTCT care and those LTFU during PMTCT were held. Ten focus-group discussions involving a total of 112 participants were also conducted with caretakers/ relatives of the PMTCT clients. Content analysis was performed to identify recurrent themes. Results Our findings indicate that LTFU during PMTCT in eastern Uganda was due to sex inequality, high transport costs to access the services, inadequate posttest counseling, lack of HIV status disclosure, and the isolated/exposed location of the ART clinic, which robs the clients of their privacy. Conclusion There is a need for approaches that empower women with social capital, knowledge, and skills to influence health-seeking practices. There is also a need to train low-ranking staff and take PMTCT services closer to the clients at the lower-level units to make them affordable and accessible to rural clients. Posttest counseling should be improved to enable PMTCT clients to appreciate the importance of PMTCT services through increasing the number of staff in antenatal care to match the client numbers for improved quality. The counseling should emphasize HIV status disclosure to partners and encourage partner escort for antenatal care visits for further counseling. The exposed and isolated ART clinic should be integrated with the other regular outpatient services to reduce the labeling stigma. PMID:23737663

  3. Direct numerical simulations of turbulent flow through a stationary and rotating infinite serpentine passage

    NASA Astrophysics Data System (ADS)

    Laskowski, Gregory M.; Durbin, Paul A.

    2007-01-01

    Serpentine passages are found in a number of engineering applications including turbine blade cooling passages. The design of effective cooling passages for high-temperature turbine blades depends in part on the ability to predict heat transfer, thus requiring an accurate representation of the turbulent flow field. These passages are subjected to strong curvature and rotational effects, and the resulting turbulent flow field is fairly complex. An understanding of the flow physics for flows with strong curvature and rotation is required in order to improve the design of turbine blade cooling passages. Experimental measurements of certain turbulence quantities for such configurations can be challenging to obtain, especially near solid surfaces, making the serpentine passage an ideal candidate for a direct numerical simulation (DNS). A DNS study has been conducted to investigate the coupled effect of strong curvature and rotation by simulating turbulent flow through a fully developed, smooth wall, round-ended, isothermal serpentine channel subjected to orthogonal mode rotation. The geometry investigated has an average radius of curvature Rc/δ=2.0 in the curved section and dimensions 12πδ×2δ×3πδ in the streamwise, transverse, and spanwise directions. The computational domain consists of periodic inflow/outflow boundaries, two solid wall boundaries, and periodic boundaries in the spanwise direction. The simulations were conducted for Reynolds number, Reb=5600, and rotation numbers, Rob ,z=0 and 0.32. Differences observed between the stationary and rotating cases are discussed in terms of the mean velocity, secondary flow, and Reynolds stresses.

  4. Injection drug users’ involvement in drug dealing in the downtown eastside of Vancouver: Social organization and systemic violence

    PubMed Central

    Small, Will; Maher, Lisa; Lawlor, Jeff; Wood, Evan; Shannon, Kate; Kerr, Thomas

    2014-01-01

    Background Illicit drug markets are a key component of the risk environment surrounding injection drug use. However, relatively few studies have explored how injection drug users’ (IDUs) involvement in drug dealing shapes their experiences of drug market-related harm. This exploratory qualitative study aims to understand IDUs’ dealing activities and roles, as well as the perceived benefits and risks related to participation in illicit drug markets, including experiences of drug market violence. Methods Ten IDUs with extensive involvement in drug dealing activities were recruited from the Vancouver Injection Drug User Study (VIDUS) and participated in semi-structured qualitative interviews, which elicited discussion of experiences dealing drugs, perceived benefits and hazards related to dealing, and understandings of drug market violence. Results Participant's involvement in drug market activities included corporate sales, freelance or independent sales, and opportunistic sales termed “middling” as well as drug market-related hustles entailing selling bogus drugs and robbing dealers. Participants primarily dealt drugs to support their own illicit drug use, and we found that arrest and criminal justice involvement, hazards stemming from drug debts, and drug market-related violence were key risks related to dealing activities. Conclusion The challenges of managing personal consumption while selling drugs exacerbates the hazards associated with drug dealing. Efforts to address drug dealing among IDUs should consider both drug dependency and the material conditions that propel drug users towards dealing activities. Interventions should explore the potential of combining enhanced drug treatment programs with low threshold employment and alternative income generation opportunities. PMID:23664788

  5. Does Plant Origin Influence the Fitness Impact of Flower Damage? A Meta-Analysis.

    PubMed

    González-Browne, Catalina; Murúa, Maureen M; Navarro, Luis; Medel, Rodrigo

    2016-01-01

    Herbivory has been long considered an important component of plant-animal interactions that influences the success of invasive species in novel habitats. One of the most important hypotheses linking herbivory and invasion processes is the enemy-release hypothesis, in which exotic plants are hypothesized to suffer less herbivory and fitness-costs in their novel ranges as they leave behind their enemies in the original range. Most evidence, however, comes from studies on leaf herbivory, and the importance of flower herbivory for the invasion process remains largely unknown. Here we present the results of a meta-analysis of the impact of flower herbivory on plant reproductive success, using as moderators the type of damage caused by floral herbivores and the residence status of the plant species. We found 51 papers that fulfilled our criteria. We also included 60 records from unpublished data of the laboratory, gathering a total of 143 case studies. The effects of florivory and nectar robbing were both negative on plant fitness. The methodology employed in studies of flower herbivory influenced substantially the outcome of flower damage. Experiments using natural herbivory imposed a higher fitness cost than simulated herbivory, such as clipping and petal removal, indicating that studies using artificial herbivory as surrogates of natural herbivory underestimate the real fitness impact of flower herbivory. Although the fitness cost of floral herbivory was high both in native and exotic plant species, floral herbivores had a three-fold stronger fitness impact on exotic than native plants, contravening a critical element of the enemy-release hypothesis. Our results suggest a critical but largely unrecognized role of floral herbivores in preventing the spread of introduced species into newly colonized areas. PMID:26785039

  6. Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry.

    PubMed

    Adamowicz, Piotr; Kała, Maria

    2010-05-20

    Date-rape drugs (DRDs) are used for the purpose of "drugging" unsuspected victims and raping or robbing them while under the influence of the drug. The wide variety of substances used for criminal purposes, their low concentrations in body fluids and, often, a long time delay between the event and clinical examination make comprehensive screening analysis of biological materials collected from crime victims for the presence of these drugs very difficult. Detection of a drug used to facilitate sexual assault in biological fluids can be very important evidence of a committed crime. The purpose of this study was to develop a simple GC-EI-MS screening procedure for date-rape drugs in urine. Target analytes were isolated by solid-phase extraction. 2-mL urine samples were extracted and then derivatized by using BSTFA+1%TMCS reagent. Detection of all compounds was based on full-scan mass spectra and for each compound one ion was chosen for further quantification. The method allowed the simultaneous screening, detection and quantification of 128 compounds from different groups (number of compounds): opioids (20), amphetamines (11), GHB and related products (3), hallucinogens (9), benzodiazepines (18), antihistamines (9), antidepressants (14), selective serotonin-reuptake inhibitors (4), antipsychotics (7), barbiturates (7), other sedatives (5), muscle relaxants (2) and other drugs (19). The procedure can easily be expanded to encompass more substances. The developed method appeared to be suitable for screening for the target DRDs. The procedure was successfully applied to the analysis of authentic urine samples collected from victims of rapes and other crimes in routine casework. PMID:20207513

  7. Neutron Characterization of Additively Manufactured Components. Workshop Report

    SciTech Connect

    Watkins, Thomas R.; Payzant, E. Andrew; Babu, Sudarsanam Suresh

    2015-09-01

    Additive manufacturing (AM) is a collection of promising manufacturing methods that industry is beginning to explore and adopt. Macroscopically complicated and near net shape components are being built using AM, but how the material behaves in service is a big question for industry. Consequently, AM components/materials need further research into exactly what is made and how it will behave in service. This one and a half day workshop included a series of invited presentations from academia, industry and national laboratories (see Appendix A for the workshop agenda and list of talks). The workshop was welcomed by Alan Tennant, Chief Scientist, Neutron Sciences Directorate, ORNL, and opened remotely by Rob Ivestor, Deputy Director, Advanced Manufacturing Office-DOE, who declared AM adoptees as titans who will be able to create customized 3-D structures with 1 million to 1 billion micro welds with locally tailored microstructures. Further he stated that characterization with neutrons is key to be able to bring critical insight/information into the AM process/property/behavior relationship. Subsequently, the presentations spanned a slice of the current state of the art AM techniques and many of the most relevant characterization techniques using neutrons. After the talks, a panel discussion was held; workshop participants (see Appendix B for a list of attendees) providing questions and the panel answers. The main purpose of the panel discussion was to build consensus regarding the critical research needs in AM that can be addressed with neutrons. These needs were placed into three categories: modes of access for neutrons, new capabilities needed, new AM material issues and neutrons. Recommendations from the workshop were determined based on the panel discussion.

  8. Sensationalising the Female Pudenda: An Examination of Public Communication of Aesthetic Genital Surgery

    PubMed Central

    Ashong, Ashong C.; Batta, Herbert E.

    2013-01-01

    We live in a society where beauty and sensations are important. Advances in medical technologies have brought on waves of new notions of beauty where commercial interests both in the media and the health industry spurred by fashion, advertising and celebrity promotion have tended to popularise body modifications and enhancements. In recent times, through offerings on cable television channels and glossy consumer magazines, medical procedures hitherto only in the precincts of medical schools, gyneacological clinics and medical journals have now pervaded the population. More seriously, on the Internet particularly, medical experts now offer services and graphic details of labiaplasty, clitoral hood reduction or enhancement, vaginal rejuvenation, etc. Here, we examine the public communication of the phenomenon of aesthetic genital surgery and interrogate thus; is it decent, honest, balanced and ethical? Relying on textual analysis, personal observation and literature review for data gathering, we observe that besides tending to commercialise and medicalise the female genitalia, a coalescence of medical, advertising and fashion interests as played out in the media sensationalises the benign science of plastic surgery and robs it of its truthfulness, genuineness, and purposefulness. The conclusion is that in Africa, where the effect of the development crises is telling, the hype surrounding cosmetic or aesthetic genital surgery is a damaging distraction particularly when the continent is waging a battle against female genital mutilation. The recommendations are that media and medical regulatory bodies should impress it upon media and medical industry operators that glaring commercial promotions of cosmetic genital surgery in the public media be checked, and that such communication should bear equal weight of facts related to risks, short comings, complications, and threats; in physical, social, and psychological terms. PMID:23445703

  9. Autumn invasion rates of Varroa destructor (Mesostigmata: Varroidae) into honey bee (Hymenoptera: Apidae) colonies and the resulting increase in mite populations.

    PubMed

    Frey, Eva; Rosenkranz, Peter

    2014-04-01

    The honey bee parasite Varroa destructor Anderson & Trueman can disperse and invade honey bee colonies by attaching to "drifting" and "robbing" honey bees that move into nonnatal colonies. We quantified the weekly invasion rates and the subsequent mite population growth from the end of July to November 2011 in 28 honey bee colonies kept in two apiaries that had high (HBD) and low (LBD) densities of neighboring colonies. At each apiary, half (seven) of the colonies were continuously treated with acaricides to kill all Varroa mites and thereby determine the invasion rates. The other group of colonies was only treated before the beginning of the experiment and then left untreated to record Varroa population growth until a final treatment in November. The numbers of bees and brood cells of all colonies were estimated according to the Liebefeld evaluation method. The invasion rates varied among individual colonies but revealed highly significant differences between the study sites. The average invasion rate per colony over the entire 3.5-mo period ranged from 266 to 1,171 mites at the HBD site compared with only 72 to 248 mites at the LBD apiary. In the untreated colonies, the Varroa population reached an average final infestation in November of 2,082 mites per colony (HBD) and 340 mites per colony (LBD). All colonies survived the winter; however, the higher infested colonies lost about three times more bees compared with the lower infested colonies. Therefore, mite invasion and late-year population growth must be considered more carefully for future treatment concepts in temperate regions.

  10. A critical overview of the current myofascial pain literature - October 2015.

    PubMed

    Dommerholt, Jan; Grieve, Rob; Hooks, Todd; Layton, Michelle

    2015-10-01

    The number of publications about myofascial pain and trigger points (TrP) seems to increase every year. In the current overview we include 27 articles published in past months. The Basic Review section includes articles about the presence and characteristics of TrPs in various neck and shoulder muscles, the correlation between referred pain from active TrPs and knee osteoarthritis, and an anatomical study exploring whether the location of TrPs may be related to the nerve innervation of muscles. Zuil-Escobar and colleagues from Spain considered the intra-rater reliability of the identification of latent TrPs in several leg muscles and the possible correlation of TrP and the presence of a lower medial longitudinal arch. In the section on manual approaches, contributing author Rob Grieve and colleagues continue their studies of TrPs in the lower extremity muscles, while Méndez-Rebolledo and colleagues studied the impact of cross taping and compression. Dry needling (DN) continues to be a topic of interest. We included twelve papers addressing a wide range of topics, such as the effectiveness and safety of DN, and the impact of DN on proprioception, spasticity, and fibromyalgia. Two papers investigated the utilization of repetitive transcranial magnetic stimulation and laser on TrPs, The final section on other clinical studies and reviews includes 8 papers. The studies originated in thirteen different countries with Spain leading the charts with 7 contributions to the literature, followed by Brazil with four. As we have mentioned in previous editions of this literature overview, many studies suffer from very small sample sizes, which makes it difficult to reach definitive conclusions. Nevertheless, myofascial pain continues to be a topic of interest to researchers and clinicians around the globe. PMID:26592232

  11. Impunity or immunity: wartime male rape and sexual torture as a crime against humanity.

    PubMed

    Zawati, Hilmi M

    2007-01-01

    This paper seeks to analyze the phenomenon of wartime rape and sexual torture of Croatian and Iraqi men and to explore the avenues for its prosecution under international humanitarian and human rights law. Male rape, in time of war, is predominantly an assertion of power and aggression rather than an attempt on the part of the perpetrator to satisfy sexual desire. The effect of such a horrible attack is to damage the victim's psyche, rob him of his pride, and intimidate him. In Bosnia- Herzegovina, Croatia, and Iraq, therefore, male rape and sexual torture has been used as a weapon of war with dire consequences for the victim's mental, physical, and sexual health. Testimonies collected at the Medical Centre for Human Rights in Zagreb and reports received from Iraq make it clear that prisoners in these conflicts have been exposed to sexual humiliation, as well as to systematic and systemic sexual torture. This paper calls upon the international community to combat the culture of impunity in both dictator-ruled and democratic countries by bringing the crime of wartime rape into the international arena, and by removing all barriers to justice facing the victims. Moreover, it emphasizes the fact that wartime rape is the ultimate humiliation that can be inflicted on a human being, and it must be regarded as one of the most grievous crimes against humanity. The international community has to consider wartime rape a crime of war and a threat to peace and security. It is in this respect that civilian community associations can fulfill their duties by encouraging victims of male rape to break their silence and address their socio-medical needs, including reparations and rehabilitation.

  12. An Innovative Collaboration on Dark Skies Education

    NASA Astrophysics Data System (ADS)

    Walker, Constance E.; Mayer, M.; EPO Students, NOAO

    2011-01-01

    Dark night skies are being lost all over the globe, and hundreds of millions of dollars of energy are being wasted in the process.. Improper lighting is the main cause of light pollution. Light pollution is a concern on many fronts, affecting safety, energy conservation, cost, human health, and wildlife. It also robs us of the beauty of viewing the night sky. In the U.S. alone, over half of the population cannot see the Milky Way from where they live. To help address this, the National Optical Astronomy Observatory Education and Public Outreach (NOAO EPO) staff created two programs: Dark Skies Rangers and GLOBE at Night. Through the two programs, students learn about the importance of dark skies and experience activities that illustrate proper lighting, light pollution's effects on wildlife and how to measure the darkness of their skies. To disseminate the programs locally in an appropriate yet innovative venue, NOAO partnered with the Cooper Center for Environmental Learning in Tucson, Arizona. Operated by the largest school district in Tucson and the University of Arizona College of Education, the Cooper Center educates thousands of students and educators each year about ecology, science, and the beauty and wonders of the Sonoran Desert. During the first academic year (2009-2010), we achieved our goal of reaching nearly 20 teachers in 40 classrooms of 1000 students. We gave two 3-hour teacher-training sessions and provided nineteen 2.5-hour on-site evening sessions on dark skies activities for the students of the teachers trained. One outcome of the program was the contribution of 1000 "GLOBE at Night 2010” night-sky brightness measurements by Tucson students. Training sessions at similar levels are continuing this year. The partnership, planning, lesson learned, and outcomes of NOAO's collaboration with the environmental center will be presented.

  13. Paraquat regulation of hmp (flavohemoglobin) gene expression in Escherichia coli K-12 is SoxRS independent but modulated by sigma S.

    PubMed Central

    Membrillo-Hernández, J; Kim, S O; Cook, G M; Poole, R K

    1997-01-01

    We report the first example of a gene, hmp, encoding a soluble flavohemoglobin in Escherichia coli K-12, which is up-regulated by paraquat in a SoxRS-independent manner. Unlike what is found for other paraquat-inducible genes, high concentrations of paraquat (200 microM) were required to increase the level of hmp expression, and maximal induction was observed only after 20 min of exposure to paraquat. Neither a mutation in soxS nor one in soxR prevented the paraquat-dependent increase in phi(hmp-lacZ) expression, but either mutant allele delayed full expression of phi(hmp-lacZ) activity after paraquat addition. Induction of hmp by paraquat was demonstrated in aerobically grown cultures during exponential growth and the stationary phase, thus revealing two Sox-independent regulatory mechanisms. Induction of hmp by paraquat in the stationary phase was dependent on the global regulator of stationary-phase gene expression, RpoS (sigma S). However, a mutation in rpoS did not prevent an increase in hmp expression by paraquat in exponentially growing cells. Induction of sigma S in the exponential phase by heat shock also induced phi(hmp-lacZ) expression in the presence of paraquat, supporting the role of sigma S in one of the regulatory mechanisms. Mutations in oxyR or rob, known regulators of several stress promoters in E. coli, had no effect on the induction of hmp by paraquat. Other known superoxide-generating agents (plumbagin, menadione, and phenazine methosulfate) were not effective in inducing hmp expression. PMID:9150210

  14. Development of Polymer Gel Systems to Improve Volumetric Sweep and Reduce Producing Water/Oil Ratios

    SciTech Connect

    G. Paul Willhite; Stan McCool; Don W. Green; Min Cheng; Feiyan Chen

    2005-04-03

    Gelled polymer treatments are applied to oil reservoirs to increase oil production and to reduce water production by altering the fluid movement within the reservoir. This report describes the results of the third year of a 42 month research program that is aimed at an understanding of gelation chemistry and the fundamental mechanisms that alter the flows of oil and water in reservoir rocks after a gel treatment. Work focused on a widely applied system in the field, the partially hydrolyzed polyacrylamide-chromium acetate gel. Gelation occurs by network formation through the crosslinking of polyacrylamide molecules as a result of reaction with chromium acetate. Pre-gel aggregates form and grow as reactions between chromium acetate and polyacrylamide proceed. A mathematical model that describes uptake and crosslinking reactions as a function of time was derived. The model was probability based and provides molecular-weight averages and molecular-weight distributions of the pre-gel aggregates as a function of time and initial system conditions. A liquid chromatography apparatus to experimentally measure the size and molecular weight distributions of polymer samples was developed. The method worked well for polymer samples without the chromium crosslinker. Sample retention observed during measurements of gelant samples during the gelation process compromised the results. Other methods will be tested to measure size distributions of the pre-gel aggregates. Dissolution of carbonate minerals during the injection of gelants causes the pH of the gelant to increase. Chromium precipitates from solution at the higher pH values robbing the gelant of crosslinker. Experimental data on the transport of chromium acetate solutions through dolomite cores were obtained. A mathematical model that describes the transport of brine and chromium acetate solutions through rocks containing carbonate minerals was used to simulate the experimental results.

  15. Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan.

    PubMed

    Sanbongi, Yumiko; Suzuki, Takahisa; Osaki, Yumi; Senju, Nami; Ida, Takashi; Ubukata, Kimiko

    2006-07-01

    A total of 621 clinical isolates of Haemophilus influenzae collected in Japan between 1995 and 2003 were studied for their susceptibilities to several antimicrobial agents, beta-lactamase production, and amino acid substitutions in penicillin-binding protein 3 (PBP 3). Over the four study periods (first period, 1995 to 1996; second period, 1997 to 1998; third period, 2000 to 2001; fourth period, 2002 to 2003), the susceptibilities to beta-lactam agents decreased and the incidence of isolates with substitutions at positions 377, 385, 389, 517, and/or 526 in PBP 3 increased from 28.8% to 52.0%. Five hundred seventy-one beta-lactamase-nonproducing isolates were grouped into 18 classes, based on the pattern of the five mutations in PBP 3. The Asp526Lys substitution led to 6.0-, 4.3-, 2.4-, and 5.4-fold increases in amoxicillin-clavulanic acid, cefdinir, cefditoren, and faropenem resistance, respectively. PBP 3 with multiple substitutions (Met377Ile, Ser385Thr, and/or Leu389Phe) together with Asp526Lys resulted in increased resistance compared to that for PBP 3 with the Asp526Lys substitution alone. These results indicate that mutations at these five positions increased resistance to most beta-lactams. Although a significant change in the prevalence of beta-lactamase-producing strains was not observed, the proportions of those possessing both PBP 3 alterations and beta-lactamase production have slightly increased (from 1.4% to 5.0%). The ROB-1 beta-lactamase was rare, but this is the first report of this beta-lactamase in Japan. PMID:16801430

  16. Atmospheric Radiation Measurement Program facilities newsletter, July 1999.

    SciTech Connect

    Sisterson, D. L.

    1999-07-30

    Summer research efforts continue in July with the SGP99 Hydrology Campaign headed by the US Department of Agriculture, Agricultural Research Service. Other participants are the National Aeronautics and Space Administration (NASA), the National Oceanic and Atmospheric Administration, and the ARM Program. This campaign focuses on measuring soil moisture by using satellite-based instruments and takes place July 7--22, 1999. Soil moisture is an important component of Earth's hydrologic cycle and climate, but the understanding of it and the ability to measure it accurately are limited. Scientists need to understand soil moisture better so that it can be incorporated correctly into general circulation models. As an important factor in growing crops, soil moisture dictates a farmer's success or failure. Too much soil moisture can drown out croplands and cause flooding, whereas too little can lead to drought conditions, robbing crops of their life-supporting water. Decisions about which crops to plant and other land use issues depend on the understanding of soil moisture patterns. Soil moisture can be measured in various ways. ARM employs several direct methods using soil moisture probes buried from 1 inch to 6.5 feet below the surface. One type of probe has two stainless steel screens separated by a piece of fiberglass. Electrical resistance, which is a function of soil moisture content, is measured between the screens. Another type of probe measures soil temperature and the increase in temperature after the soil is heated by small heating element. From this measurement, the volume of water in the soil can be calculated.

  17. AIDS. Grim news for Asia.

    PubMed

    1992-12-01

    While Asia was the last region to be exposed to the global spread of HIV and AIDS, the incidence of HIV infection there is increasing fastest. The Asian Development Bank predicts mortality from AIDS will cause some town and village populations to begin declining by the year 2000. With an estimated 1 million people infected in India, and 400,000 in Thailand, these 2 countries are particularly exposed to the risk of epidemic HIV spread. In 5 years, more people may be affected by AIDS in India than anywhere else in the world. Concern over a growing presence of HIV is also merited for the Philippines, Indonesia, China, and the drug trade's Golden Triangle. The Second International Conference on AIDS in Asia and the Pacific in November 1992 stressed that AIDS no longer affects only homosexual and IV drug using populations. 50% of new infections worldwide in the first half of 1992 were among women, 65% of Thailand's AIDS cases are among heterosexuals, and 3-5% of Thailand's long-haul truck drivers have tested positive for HIV infection. HIV and AIDS robs economies and societies of their best workers. The immediate costs of caring for AIDS patients will pale next to the far greater losses to be realized in private sector economic productivity. Asia's more developed economies will probably be able to survive the epidemic, but small, poor countries like Laos will wilt. Prompt action must be taken to overcome public and religious ignorance and objections to promoting and using condoms throughout the region. For the first time, Beijing has organized an AIDS awareness conference for male homosexuals. Further, Singapore has implemented compulsory testing for lower-income foreign workers. Pakistan has even solicited educational assistance and support from Islamic religious leaders; similar action is being considered in Bangladesh. PMID:12285939

  18. Impunity or immunity: wartime male rape and sexual torture as a crime against humanity.

    PubMed

    Zawati, Hilmi M

    2007-01-01

    This paper seeks to analyze the phenomenon of wartime rape and sexual torture of Croatian and Iraqi men and to explore the avenues for its prosecution under international humanitarian and human rights law. Male rape, in time of war, is predominantly an assertion of power and aggression rather than an attempt on the part of the perpetrator to satisfy sexual desire. The effect of such a horrible attack is to damage the victim's psyche, rob him of his pride, and intimidate him. In Bosnia- Herzegovina, Croatia, and Iraq, therefore, male rape and sexual torture has been used as a weapon of war with dire consequences for the victim's mental, physical, and sexual health. Testimonies collected at the Medical Centre for Human Rights in Zagreb and reports received from Iraq make it clear that prisoners in these conflicts have been exposed to sexual humiliation, as well as to systematic and systemic sexual torture. This paper calls upon the international community to combat the culture of impunity in both dictator-ruled and democratic countries by bringing the crime of wartime rape into the international arena, and by removing all barriers to justice facing the victims. Moreover, it emphasizes the fact that wartime rape is the ultimate humiliation that can be inflicted on a human being, and it must be regarded as one of the most grievous crimes against humanity. The international community has to consider wartime rape a crime of war and a threat to peace and security. It is in this respect that civilian community associations can fulfill their duties by encouraging victims of male rape to break their silence and address their socio-medical needs, including reparations and rehabilitation. PMID:17456904

  19. The 2012 Total Eclipse Expeditions in Queensland

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Babcock, B. A.; Lu, M.; Dantowitz, R.; Lucas, R.; Seiradakis, J. H.; Voulgaris, A.; Gaintatzis, P.; Steele, A.; Sterling, A. C.; Rusin, V.; Saniga, M.

    2013-07-01

    A total eclipse swept across Queensland and other sites in northeastern Australia on the early morning of 14 November 2012, local time. We mounted equipment to observe coronal images and spectra during the approximately 2 minutes of totality, the former for comparison with spacecraft images and to fill in the doughnut of imaging not well covered with space coronagraphs. Matching weather statistics, viewing was spotty, and our best observations were from a last-minute inland site on the Tablelands, with some observations from a helicopter at 9000 feet altitude over our original viewing site at Miallo. Only glimpses of the corona were visible at our Port Douglas and Trinity Beach, Cairns, locations, with totality obscured from our sites at Newell and Miallo, though some holes in the clouds provided coronal views from Palm Cove and elsewhere along the coast. Preliminary analysis of the spectra again shows Fe XIV stronger than Fe X, as in 2010 but not earlier, a sign of solar maximum, as was the coronal shape. An intriguing CME is discernible in the SE. Acknowledgments: We thank Terry Cuttle, Aram Friedman, Michael Kentrianakis, and Nicholas Weber for assistance and collaboration in Australia and Wendy Carlos for image processing. Our expedition was supported in part by NSF grant AGS-1047726 from Solar Terrestrial Research of the Atmospheric and Geospace Sciences Division, and by the Rob Spring Fund and Science Center funds at Williams College. ML was also supported in part by a Grant-In-Aid of Research from the National Academy of Sciences, administered by Sigma Xi, The Scientific Research Society (Grant ID: G20120315159311). VR and MS acknowledge support from projects VEGA 2/0003/13 and NGS-3139-12 of the National Geographic Society. We are grateful to K. Shiota (Japan) for kindly providing us with some of his 2012 eclipse coronal images.

  20. Vital Statistics of Triatominae (Hemiptera: Reduviidae) Under Laboratory Conditions: IV. Panstrongylus geniculatus.

    PubMed

    Rabinovich, Jorge Eduardo; Feliciangeli, M Dora

    2015-09-01

    A cohort of 100 eggs of Panstrongylus geniculatus (Latreille) was reared in the laboratory under constant conditions (temperature 26 ± 1°C, 60 ± 10% RH), with mortality and fecundity data recorded weekly. We calculated stage-specific development times, age-specific mortality and fecundity (18.4 eggs/♀/wk), and stage-specific and total preadult mortality (31.6%), and the weekly intrinsic rate of natural increase (r(o) = 0.096), the finite population growth rate (λ = 1.109), the net reproductive rate (R(0) = 60.45), and the generation time (T = 46.34 wk). Elasticity analysis showed that the dominant life-history trait determining λ was survival (particularly the adult female's survival). Adult females dominated the stage-specific reproductive value, and the egg stage dominated the stable stage distribution (SSD). The damping ratio (ρ = 1.096) suggests a relatively rapid period of recovery to a disturbed SSD. Results were compared with one previous study and conform relatively well, considering that environmental conditions were not the same. We estimated the colonizing ability of P. geniculatus, using as a criterion the ro/b index, and obtained the value of 0.74, an indicator of a good colonizer, and similar to well-known invasive species such as Rhodnius prolixus and Triatoma infestans. The life history traits and demographic parameters here presented for P. geniculatus are discussed in terms of their usefulness for evolutionary studies and vector control activities. PMID:26336251

  1. Does Plant Origin Influence the Fitness Impact of Flower Damage? A Meta-Analysis

    PubMed Central

    González-Browne, Catalina; Murúa, Maureen M.; Navarro, Luis; Medel, Rodrigo

    2016-01-01

    Herbivory has been long considered an important component of plant-animal interactions that influences the success of invasive species in novel habitats. One of the most important hypotheses linking herbivory and invasion processes is the enemy-release hypothesis, in which exotic plants are hypothesized to suffer less herbivory and fitness-costs in their novel ranges as they leave behind their enemies in the original range. Most evidence, however, comes from studies on leaf herbivory, and the importance of flower herbivory for the invasion process remains largely unknown. Here we present the results of a meta-analysis of the impact of flower herbivory on plant reproductive success, using as moderators the type of damage caused by floral herbivores and the residence status of the plant species. We found 51 papers that fulfilled our criteria. We also included 60 records from unpublished data of the laboratory, gathering a total of 143 case studies. The effects of florivory and nectar robbing were both negative on plant fitness. The methodology employed in studies of flower herbivory influenced substantially the outcome of flower damage. Experiments using natural herbivory imposed a higher fitness cost than simulated herbivory, such as clipping and petal removal, indicating that studies using artificial herbivory as surrogates of natural herbivory underestimate the real fitness impact of flower herbivory. Although the fitness cost of floral herbivory was high both in native and exotic plant species, floral herbivores had a three-fold stronger fitness impact on exotic than native plants, contravening a critical element of the enemy-release hypothesis. Our results suggest a critical but largely unrecognized role of floral herbivores in preventing the spread of introduced species into newly colonized areas. PMID:26785039

  2. Vital Statistics of Triatominae (Hemiptera: Reduviidae) Under Laboratory Conditions: IV. Panstrongylus geniculatus.

    PubMed

    Rabinovich, Jorge Eduardo; Feliciangeli, M Dora

    2015-09-01

    A cohort of 100 eggs of Panstrongylus geniculatus (Latreille) was reared in the laboratory under constant conditions (temperature 26 ± 1°C, 60 ± 10% RH), with mortality and fecundity data recorded weekly. We calculated stage-specific development times, age-specific mortality and fecundity (18.4 eggs/♀/wk), and stage-specific and total preadult mortality (31.6%), and the weekly intrinsic rate of natural increase (r(o) = 0.096), the finite population growth rate (λ = 1.109), the net reproductive rate (R(0) = 60.45), and the generation time (T = 46.34 wk). Elasticity analysis showed that the dominant life-history trait determining λ was survival (particularly the adult female's survival). Adult females dominated the stage-specific reproductive value, and the egg stage dominated the stable stage distribution (SSD). The damping ratio (ρ = 1.096) suggests a relatively rapid period of recovery to a disturbed SSD. Results were compared with one previous study and conform relatively well, considering that environmental conditions were not the same. We estimated the colonizing ability of P. geniculatus, using as a criterion the ro/b index, and obtained the value of 0.74, an indicator of a good colonizer, and similar to well-known invasive species such as Rhodnius prolixus and Triatoma infestans. The life history traits and demographic parameters here presented for P. geniculatus are discussed in terms of their usefulness for evolutionary studies and vector control activities.

  3. Molecular studies of translocations and trisomy involving chromosome 13

    SciTech Connect

    Robinson, W.P.; Bernasconi, F.; Dutly, F.; Schinzel, A.A.

    1996-01-11

    Twenty-four cases of trisomy 13 and one case with disomy 13, but a de novo dic(13,13)(p12p12) chromosome, were examined with molecular markers to determine the origin of the extra (or rearranged) chromosome. Twenty-one of 23 informative patients were consistent with a maternal origin of the extra chromosome. Lack of a third allele at any locus in both paternal origin cases indicate a somatic duplication of the paternal chromosome occurred. Five cases had translocation trisomy. The patient with a paternal rob(13q14q) had a maternal meiotic origin of the trisomy; thus, the paternal inheritance of the translocation chromosome was purely coincidental. Since there is not a significantly increased risk for unbalanced offspring of a t(13q14q) carrier and most trisomies are maternal in origin, this result should not be surprising; however, it illustrates that one cannot infer the origin of translocation trisomy based on parental origin of the translocation. Lack of a third allele at any locus in one of the three t(13q13q) cases indicates that it was most likely an isochromosome of postmeiotic origin, whereas the other two cases showed evidence of recombination. One balanced (nontrisomic) case with a nonmosaic 45, -13, -13, +t(13;13) karyotype was also investigated and was determined to be a somatic Robertsonian translocation between the maternal and paternal homologues, as has been found for all balanced homologous Robertsonian translocations so far investigated. Thus, it is also incorrect to assume in de novo translocation cases that the two involved chromosomes are even from the same parent. Despite a maternal origin of the trisomy, we cannot therefore infer anything about the parental origin of the chromosomes 13 and 14 involved in the translocation in the de novo t(13q14q) case nor for the two t(13;13) chromosomes showing a meiotic origin of the trisomy. 30 refs., 1 fig., 2 tabs.

  4. Prevalence and Epizootical Aspects of Varroasis in Golestan Province, Northern Iran

    PubMed Central

    Bokaie, Saeid; Sharifi, Laleh; Mehrabadi, Majid

    2014-01-01

    Background: The Varroa destructor mite is considered as a major pest of honey bees Apis mellifera. The rapid spread of Varroa mites among bee colonies may be due to several factors, including drifting of infested bees, movement of bee swarms, and robbing of weakened colonies. Disease spread and predisposing the infested bees to other diseases lead to high economic losses in beekeeping industries. The aim of this study was to determine the prevalence of and evaluate some managing factors in Golestan Province in Iran in 2008. Methods: According to the records of Agricultural Research Center, 80 infested beekeeping centers identified and a questionnaire consists of managing factors for each center has been designed. All data were recorded and analyzed by SPSS software to calculate χ2 test. Results: Among 80 apiculture centers, 72 centers (92%) were infested to Varroa and hive density of 90.6% of the centers was 31–60 hives in one center (P= 0.324). All of the apiculture centers had more than 6 km distance to nearest beekeeping center (P= 0.687). Amongst bee keepers 15(93.8%) had low literacy level (P= 0.479) and 26(89.7%) had 5–10 years experience in beekeeping (P= 0.953). Conclusion: We can conclude that because of the high prevalence of the disease, the usual methods of prevention are not effective. This high prevalence emphasizes that we are very far from a solution for Varroa infestation and extra researches on mite biology, tolerance breeding, and Varroa treatment is immediately required. PMID:25629070

  5. A multi-secular sunspot number perspective on the current solar cycle

    NASA Astrophysics Data System (ADS)

    Lefevre, Laure; Clette, Fr

    The international sunspot number (SSN), maintained at the World Data Center (WDC) in Brussels, is widely used as the main reference index characterizing the long-term evolution of solar activity over time-scales of decades to centuries. It provides an essential reference for characterizing how the solar output has varied over centuries and thus for assessing the variations of the main natural forcing on the Earth climate. It also serves as a key input to most solar cycle prediction methods. Given the recent unexpected changes in cycles 23 and 24, and the persistent lack of success in predicting their strength, it has become even more important to better understand the historical evolution of this prime index and to assess the long-term stability of its absolute scale. A full revision of the SSN has been undertaken in the framework of the SSN Workshop series organized jointly by the National Solar Observatory (NSO) and the Royal Observatory of Belgium (ROB) since 2010. Here, we will report about the resulting changes to this secular time series and their implications for our understanding of the long-term solar cycle evolution. In particular, the uniqueness of the recent "Modern Maximum" will be considered. We will also review the evidence for the recent deficit of small spots and the parallel decline of the average sunspot core magnetic field and show how such subtle solar trends can explain the reported divergence between the sunspot number and several other solar activity indices, like the F10.7cm radio flux. Taking advantage of the 400-year perspective offered by the sunspot record, we will also conclude on limitations of recent solar cycle prediction attempts, now that cycle 24 has possibly reached its actual maximum.

  6. Joining together to combat poverty.

    PubMed

    Heath, I; Haines, A; Malenica, Z; Oulton, J A; Leopando, Z; Kaseje, D; Addington, W W; Giscard D'Estaing, O; Tumwine, J K; Koivusalo, M; Biscoe, G; Nickson, P; Marusić, M; Vuk Pavlović, S

    2000-03-01

    The International Poverty and Health Network (IPHN) was created in December 1997 following a series of conferences organized by the World Health Organization, with the aim of integrating health into plans to eradicate poverty. Around 1.3 billion people live on less than US$1 per day. Of the 4.4 billion people in developing countries nearly 60% lack access to sanitation, 30% do not have clean water, 20% have no health care, and 20% do not have enough dietary energy and protein. Even among rich nations there are gross socioeconomic inequalities. Many children are robbed of their physical and mental potential through poverty. Expressed in constant 1963 US dollars, an average Croatian family needed the annual income of US$894 to meet the poverty line in 1960 and US$9,027 in 1995. Accordingly, 9-25% of Croatian households were below the poverty line between 1960 and 1995. The increase in the poverty rate after 1991 was compounded by the war that destroyed almost a third of industrial capacity and infrastructure. Dissipation of the communist economy and inadequate privatization have contributed to the increase in unemployment rate, corruption, and other social ills. IPHN invited Croatian Medical Journal to publish this editorial to help push the issue of poverty up political and medical agendas on a global level. We argue that a factor contributing to the failure of most large-scale programs against poverty to date is the excessive emphasis on material and infrastructure assistance at the expense of spiritual, moral, and intellectual development.

  7. Crystal structure and chemistry of lithium-bearing trioctahedral micas-3T

    USGS Publications Warehouse

    Brigatti, M.F.; Kile, D.E.; Poppi, L.

    2003-01-01

    Chemical analyses and crystal structure refinements were performed on lithian siderophyllite-3T crystals from granitic pegmatites of the anorogenic Pikes Peak batholith (Colorado) to characterize the crystal chemistry and relations with trioctahedral lithium-bearing micas showing different stacking sequences. Chemical data show that the studied samples fall on the siderophyllite-polylithionite join, closer to the siderophyllite end-member. Single-crystal X-ray refinements were carried out on three samples (two of which were taken from core and rim of the same crystal) in space-group P31 12 (the agreement factor, Robs, varies between 0.034 and 0.036). Mean bond distances and mean electron counts of M1, M2 and M3 octahedral sites indicate an ordered cation distribution with M1 and M3 positions substantially larger than M2. In the sample with the largest iron content, the M2 mean electron count increases as well as the mean distance, whereas remains smaller than or . The tetrahedral cation-oxygen atom mean distances range from 1.614 to 1.638 A?? and from 1.663 to 1.678 A?? for T1 and T2 sites, respectively, being consistent with Al3+ enrichment in the T2 sites. The tetrahedral rotation angle, ??, is generally small (3.1 ??? ?? ??? 4.6??) and decreases with siderophyllite content. As Fe increases, the T1 tetrahedron becomes flatter (112.4 ??? t??1 ??? 110.5??), whereas T2 tetrahedron distortion appears unchanged (110.7 ??? t??T2 ??? 110.9).

  8. Interspecific relationships between American coots and waterfowl during fall migration

    USGS Publications Warehouse

    Eddleman, William R.; Patterson, Craig T.; Knopf, Fritz L.

    1985-01-01

    Interactions between American Coots (Fulica americana) and water-fowl during the breeding season are well-documented (Ryder 1959, Nudds 1981). Ducks and coots use similar nesting, feeding, brooding, and loafing sites during the breeding season (Munro 1939, Sooter 1945, Ryder 1959). Coots create potential nest sites, repulse predators, provide predation buffers for ducks (Sooter 1945; Ryder 1958, 1959), and may also destroy eggs and young of other marsh-nesting birds (Munro 1937, Burger 1973, McNicholl 1975). Coots, ducks, and swans often feed cooperatively (Ryder 1959, Anderson 1974, Ryan 1981); and American Wigeon (Anas americana) and Gadwell () may rob feeding coots (Knapton and Knudsen 1978, Ryan 1981). Interspecies aggression between coots and waterfowl usually occurs when ducks approach coot nests or broods (Ryan and Dinsmore 1979). Despite these interactions, the numbers of duck broods produced in areas in Utah with nesting coots and in areas where coots have been removed were similar (Ryder 1958, 1961). Densities of coots and ducks, and brood counts of coots and ducks for a 26-year period in Saskatchewan also indicated no significant relationship between numbers of coots and waterfowl (Nudds 1981). Coots and waterfowl from large areas of breeding habitat concentrate on smaller areas during the nonbreeding season (Weller 1975:102). These species may also change diets and habitats during migration and while wintering (Weller 1975). This study documents associations between waterfowl and coots during fall migration and examines feeding and behavioral interactions between coots and waterfowl in mixed flocks. Specifically, we (1) describe temporal and spatial overlap among migrations of coots and waterfowl, (2) present behavioral interactions among species, and (3) document food habits of birds feeding sympatrically during fall migration in Oklahoma.

  9. A critical overview of the current myofascial pain literature - October 2015.

    PubMed

    Dommerholt, Jan; Grieve, Rob; Hooks, Todd; Layton, Michelle

    2015-10-01

    The number of publications about myofascial pain and trigger points (TrP) seems to increase every year. In the current overview we include 27 articles published in past months. The Basic Review section includes articles about the presence and characteristics of TrPs in various neck and shoulder muscles, the correlation between referred pain from active TrPs and knee osteoarthritis, and an anatomical study exploring whether the location of TrPs may be related to the nerve innervation of muscles. Zuil-Escobar and colleagues from Spain considered the intra-rater reliability of the identification of latent TrPs in several leg muscles and the possible correlation of TrP and the presence of a lower medial longitudinal arch. In the section on manual approaches, contributing author Rob Grieve and colleagues continue their studies of TrPs in the lower extremity muscles, while Méndez-Rebolledo and colleagues studied the impact of cross taping and compression. Dry needling (DN) continues to be a topic of interest. We included twelve papers addressing a wide range of topics, such as the effectiveness and safety of DN, and the impact of DN on proprioception, spasticity, and fibromyalgia. Two papers investigated the utilization of repetitive transcranial magnetic stimulation and laser on TrPs, The final section on other clinical studies and reviews includes 8 papers. The studies originated in thirteen different countries with Spain leading the charts with 7 contributions to the literature, followed by Brazil with four. As we have mentioned in previous editions of this literature overview, many studies suffer from very small sample sizes, which makes it difficult to reach definitive conclusions. Nevertheless, myofascial pain continues to be a topic of interest to researchers and clinicians around the globe.

  10. Population Structure, Historical Biogeography and Demographic History of the Alpine Toad Scutiger ningshanensis in the Tsinling Mountains of Central China

    PubMed Central

    Meng, Hongzhe; Li, Xiaochen; Qiao, Penghai

    2014-01-01

    Population genetic structure, historical biogeography and historical demography of the alpine toad Scutiger ningshanensis were studied using the combined data mtDNA cytochrome b (cyt b) and the mtDNA cytochrome c oxidase subunit I (COI) as the molecular markers. This species has high genetic variation. There was a significant genetic differentiation among most populations. Three lineages were detected. The phylogenetic relationship analyses and the SAMOVA (spatial analysis of molecular variance) results showed significant phylogeographic structure. 82.15% genetic variation occurred among populations whereas differentiation within populations only contributed 17.85% to the total. Mantel test results showed a significant correlation between the pairwise calculated genetic distance and pairwise calculated geographical distance of the populations (regression coefficient  = 0.001286, correlation coefficient  = 0.77051, p (rrand≥robs)  = 0.0185<0.05), indicating the existence of isolation-by-distance pattern of genetic divergence for cyt b + COI sequence, which suggests that the distribution of genetic variation is due to geographical separation rather than natural selection. The population expansion or contraction and genetic differentiation between populations or lineages could be explained by topography and the repetitive uplifts of the Tsinling Mountains and the climatic cycles during the late Pliocene and Pleistocene. S. ningshanensis experienced a rapid population expansion about 40,000 years before present. The current decline in population size was probably caused by anthropogenic disturbance. Current populations of S. ningshanensis are from different refugia though the location of these refugia could not be determined in our study. Topography, climatic changes and repetitive population expansion/contraction together led to the high level of genetic variation in S. ningshanensis. A total of three management units (MUs) was determined, which must be

  11. Social Egg Freezing: Developing Countries Are Not Exempt.

    PubMed

    Allahbadia, Gautam N

    2016-08-01

    Non-medical egg freezing has only been available for about the last 5 years, as new vitrification techniques have made the success rates for actual conception more reliable than the earlier method of slow freezing. The improved outcomes of new technologies of vitrification and intra-cytoplasmic sperm injection (ICSI) have led to the marketing of egg freezing for non-medical reasons, whereby women are offered the possibility of preserving their eggs until such time as they wish to have a child. For many women today, it is not cancer but the simple passage of time that robs them of their chance of motherhood. Social, educational, emotional and financial pressures often lead them to delay trying to start a family until their late thirties, by which time the chance of success is very low. Women at age 40 face a 40 % chance of miscarriage if they can get pregnant at all, and by the age of 45, the risk of miscarriage is 75 %. Donor eggs are not an option for many because of supply constraints and ethical and cultural concerns. Freezing a woman's eggs at age 30 literally "freezes in time" her fertility potential and gives her the chance of a healthy pregnancy at a time of her choosing. Despite the initial reactions of disapproval, more and more fertility clinics are now offering oocyte cryopreservation to healthy women in order to extend their reproductive options. This procedure is now becoming popular even in developing economies, and egg freezing in major Indian Metros is now routine. PMID:27382212

  12. CREST - a large and diverse superfamily of putative transmembrane hydrolases

    PubMed Central

    2011-01-01

    . Reviewers This article was reviewed by Kira S. Markarova, Igor B. Zhulin and Rob Knight. PMID:21733186

  13. Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

    PubMed Central

    Averette, Anna F.; Lee, Soo Chan; Kim, Taeyup; Bahn, Yong-Sun; Robbins, Nicole; Heitman, Joseph; Cowen, Leah E.

    2016-01-01

    Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in therapeutics, as the cognate inhibitors are rarely explored by conventional screening approaches. This has great potential to address the pressing need for new therapeutic strategies for invasive fungal infections, which have a staggering impact on human health. To explore this approach, we focused on a leading human fungal pathogen, Candida albicans, and screened 1,280 pharmacologically active compounds to identify those that potentiate the activity of echinocandins, which are front-line therapeutics that target fungal cell wall synthesis. We identified 19 compounds that enhance activity of the echinocandin caspofungin against an echinocandin-resistant clinical isolate, with the broad-spectrum chelator DTPA demonstrating the greatest synergistic activity. We found that DTPA increases susceptibility to echinocandins via chelation of magnesium. Whole genome sequencing of mutants resistant to the combination of DTPA and caspofungin identified mutations in the histidine kinase gene NIK1 that confer resistance to the combination. Functional analyses demonstrated that DTPA activates the mitogen-activated protein kinase Hog1, and that NIK1 mutations block Hog1 activation in response to both caspofungin and DTPA. The combination has therapeutic relevance as DTPA enhanced the efficacy of caspofungin in a mouse model of echinocandin-resistant candidiasis. We found that DTPA not only reduces drug resistance but also modulates morphogenesis, a key virulence trait that is normally regulated by environmental cues. DTPA induced filamentation via depletion of zinc, in a manner that is contingent upon Ras1-PKA signaling, as well as the transcription factors Brg1 and Rob1. Thus, we establish a new mechanism by which metal chelation

  14. New coordination polymers from 1D chain, 2D layer to 3D framework constructed from 1,2-phenylenediacetic acid and 1,3-bis(4-pyridyl)propane flexible ligands

    SciTech Connect

    Xin Lingyun; Liu Guangzhen; Wang Liya

    2011-06-15

    The hydrothermal reactions of Cd, Zn, or Cu(II) acetate salts with H{sub 2}PHDA and BPP flexible ligands afford three new coordination polymers, including [Cd(PHDA)(BPP)(H{sub 2}O)]{sub n}(1), [Zn(PHDA)(BPP)]{sub n}(2), and [Cu{sub 2}(PHDA){sub 2}(BPP)]{sub n}(3) (H{sub 2}PHDA=1,2-phenylenediacetic acid, BPP=1,3-bis(4-pyridyl)propane). The single-crystal X-ray diffractions reveal that all three complexes feature various metal carboxylate subunits extended further by the BPP ligands to form a diverse range of structures, displaying a remarked structural sensitivity to metal(II) cation. Complex 1 containing PHDA-bridged binuclear cadmium generates 1D double-stranded chain, complex 2 results in 2D{yields}2D interpenetrated (4,4) grids, and complex 3 displays a 3D self-penetrated framework with 4{sup 8}6{sup 6}8 rob topology. In addition, fluorescent analyses show that both 1 and 2 exhibit intense blue-violet photoluminescence in the solid state. - Graphical Abstract: We show diverse supramolecular frameworks based on the same ligands (PHDA and BPP) and different metal acetate salts including 1D double-stranded chain, 2D {yields} 2D twofold interpenetrated layer, and 3D self-penetration networks. Highlights: > Three metal(II = 2 /* ROMAN ) coordination polymers were synthesized using H{sub 2}PHDA and BPP. > The diversity of structures show a remarked sensitivity to metal(II) center. > Complexes show the enhancement of fluorescence compared to that of free ligand.

  15. Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code

    PubMed Central

    Bernhardt, Harold S; Tate, Warren P

    2008-01-01

    Background Transfer RNA (tRNA) is the means by which the cell translates DNA sequence into protein according to the rules of the genetic code. A credible proposition is that tRNA was formed from the duplication of an RNA hairpin half the length of the contemporary tRNA molecule, with the point at which the hairpins were joined marked by the canonical intron insertion position found today within tRNA genes. If these hairpins possessed a 3'-CCA terminus with different combinations of stem nucleotides (the ancestral operational RNA code), specific aminoacylation and perhaps participation in some form of noncoded protein synthesis might have occurred. However, the identity of the first tRNA and the initial steps in the origin of the genetic code remain elusive. Results Here we show evidence that glycine tRNA was the first tRNA, as revealed by a vestigial imprint in the anticodon loop sequences of contemporary descendents. This provides a plausible mechanism for the missing first step in the origin of the genetic code. In 448 of 466 glycine tRNA gene sequences from bacteria, archaea and eukaryote cytoplasm analyzed, CCA occurs immediately upstream of the canonical intron insertion position, suggesting the first anticodon (NCC for glycine) has been captured from the 3'-terminal CCA of one of the interacting hairpins as a result of an ancestral ligation. Conclusion That this imprint (including the second and third nucleotides of the glycine tRNA anticodon) has been retained through billions of years of evolution suggests Crick's 'frozen accident' hypothesis has validity for at least this very first step at the dawn of the genetic code. Reviewers This article was reviewed by Dr Eugene V. Koonin, Dr Rob Knight and Dr David H Ardell. PMID:19091122

  16. Reduction of cellular stress by TolC-dependent efflux pumps in Escherichia coli indicated by BaeSR and CpxARP activation of spy in efflux mutants.

    PubMed

    Rosner, Judah L; Martin, Robert G

    2013-03-01

    Escherichia coli has nine inner membrane efflux pumps which complex with the outer membrane protein TolC and cognate membrane fusion proteins to form tripartite transperiplasmic pumps with diverse functions, including the expulsion of antibiotics. We recently observed that tolC mutants have elevated activities for three stress response regulators, MarA, SoxS, and Rob, and we suggested that TolC-dependent efflux is required to prevent the accumulation of stressful cellular metabolites. Here, we used spy::lacZ fusions to show that two systems for sensing/repairing extracytoplasmic stress, BaeRS and CpxARP, are activated in the absence of TolC-dependent efflux. In either tolC mutants or bacteria with mutations in the genes for four TolC-dependent efflux pumps, spy expression was increased 6- to 8-fold. spy encodes a periplasmic chaperone regulated by the BaeRS and CpxARP stress response systems. The overexpression of spy in tolC or multiple efflux pump mutants also depended on these systems. spy overexpression was not due to acetate, ethanol, or indole accumulation, since external acetate had only a minor effect on wild-type cells, ethanol had a large effect that was not CpxA dependent, and a tolC tnaA mutant which cannot accumulate internal indole overexpressed spy. We propose that, unless TolC-dependent pumps excrete certain metabolites, the metabolites accumulate and activate at least five different stress response systems.

  17. Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry.

    PubMed

    Adamowicz, Piotr; Kała, Maria

    2010-05-20

    Date-rape drugs (DRDs) are used for the purpose of "drugging" unsuspected victims and raping or robbing them while under the influence of the drug. The wide variety of substances used for criminal purposes, their low concentrations in body fluids and, often, a long time delay between the event and clinical examination make comprehensive screening analysis of biological materials collected from crime victims for the presence of these drugs very difficult. Detection of a drug used to facilitate sexual assault in biological fluids can be very important evidence of a committed crime. The purpose of this study was to develop a simple GC-EI-MS screening procedure for date-rape drugs in urine. Target analytes were isolated by solid-phase extraction. 2-mL urine samples were extracted and then derivatized by using BSTFA+1%TMCS reagent. Detection of all compounds was based on full-scan mass spectra and for each compound one ion was chosen for further quantification. The method allowed the simultaneous screening, detection and quantification of 128 compounds from different groups (number of compounds): opioids (20), amphetamines (11), GHB and related products (3), hallucinogens (9), benzodiazepines (18), antihistamines (9), antidepressants (14), selective serotonin-reuptake inhibitors (4), antipsychotics (7), barbiturates (7), other sedatives (5), muscle relaxants (2) and other drugs (19). The procedure can easily be expanded to encompass more substances. The developed method appeared to be suitable for screening for the target DRDs. The procedure was successfully applied to the analysis of authentic urine samples collected from victims of rapes and other crimes in routine casework.

  18. Contributions of artificial lighting sources on light pollution in Hong Kong measured through a night sky brightness monitoring network

    NASA Astrophysics Data System (ADS)

    Pun, Chun Shing Jason; So, Chu Wing; Leung, Wai Yan; Wong, Chung Fai

    2014-05-01

    Light pollution is a form of environmental degradation in which excessive artificial outdoor lighting, such as street lamps, neon signs, and illuminated signboards, affects the natural environment and the ecosystem. Poorly designed outdoor lighting not only wastes energy, money, and valuable Earth resources, but also robs us of our beautiful night sky. Effects of light pollution on the night sky can be evaluated by the skyglow caused by these artificial lighting sources, through measurements of the night sky brightness (NSB). The Hong Kong Night Sky Brightness Monitoring Network (NSN) was established to monitor in detail the conditions of light pollution in Hong Kong. Monitoring stations were set up throughout the city covering a wide range of urban and rural settings to continuously measure the variations of the NSB. Over 4.6 million night sky measurements were collected from 18 distinct locations between May 2010 and March 2013. This huge dataset, over two thousand times larger than our previous survey [1], forms the backbone for studies of the temporal and geographical variations of this environmental parameter and its correlation with various natural and artificial factors. The concepts and methodology of the NSN were presented here, together with an analysis of the overall night sky conditions in Hong Kong. The average NSB in Hong Kong, excluding data affected by the Moon, was 16.8 mag arcsec-2, or 82 times brighter than the dark site standard established by the International Astronomical Union (IAU) [2]. The urban night sky was on average 15 times brighter than that in a rural location, firmly establishing the effects of artificial lighting sources on the night sky.

  19. Population structure, historical biogeography and demographic history of the alpine toad Scutiger ningshanensis in the Tsinling Mountains of Central China.

    PubMed

    Meng, Hongzhe; Li, Xiaochen; Qiao, Penghai

    2014-01-01

    Population genetic structure, historical biogeography and historical demography of the alpine toad Scutiger ningshanensis were studied using the combined data mtDNA cytochrome b (cyt b) and the mtDNA cytochrome c oxidase subunit I (COI) as the molecular markers. This species has high genetic variation. There was a significant genetic differentiation among most populations. Three lineages were detected. The phylogenetic relationship analyses and the SAMOVA (spatial analysis of molecular variance) results showed significant phylogeographic structure. 82.15% genetic variation occurred among populations whereas differentiation within populations only contributed 17.85% to the total. Mantel test results showed a significant correlation between the pairwise calculated genetic distance and pairwise calculated geographical distance of the populations (regression coefficient  = 0.001286, correlation coefficient  = 0.77051, p (rrand≥robs)  = 0.0185<0.05), indicating the existence of isolation-by-distance pattern of genetic divergence for cyt b + COI sequence, which suggests that the distribution of genetic variation is due to geographical separation rather than natural selection. The population expansion or contraction and genetic differentiation between populations or lineages could be explained by topography and the repetitive uplifts of the Tsinling Mountains and the climatic cycles during the late Pliocene and Pleistocene. S. ningshanensis experienced a rapid population expansion about 40,000 years before present. The current decline in population size was probably caused by anthropogenic disturbance. Current populations of S. ningshanensis are from different refugia though the location of these refugia could not be determined in our study. Topography, climatic changes and repetitive population expansion/contraction together led to the high level of genetic variation in S. ningshanensis. A total of three management units (MUs) was determined, which must be

  20. Floating into Deep Space

    NASA Astrophysics Data System (ADS)

    La Frenais, R.; Saraceno, T.; Powell, J.

    2014-04-01

    Is it possible for spaceflight to become more sustainable? Artist and architect Tomas Saraceno proposes a long-term artscience research project based on his initial work with solar balloons to join with the efforts of engineers such as John Powell, working on the Airship to Orbit experiments, which describe a three stage process of using airships to fly to a large suborbital "Dark Sky Station' then literally floating into orbit with additional electrical and chemical propulsion. (See: http://www.jpaerospace.com) In his artworks Tomás Saraceno proposes cell-like flying cities as possible architectonic living spaces in direct reference to Buckminster Fuller's Cloud Nine (circa 1960). The fantastic architectural utopia Cloud Nine consists of a freely floating sphere measuring one mile in diameter that offers living space to several autonomous communities encompassing thousands of inhabitants each. The notion of the cloud is essential to the artist's work. The cloud as metaphor stands for artistic intention, for the meaning of territory and border in today's (urban) society, and for exploring possibilities for the sustainable development of the human living environment. In Saraceno's work this environment is not limited to the earth, but is explicitly conceived to reach into outer space. (Biomimetic Constructions- On the works of Tomás Saraceno By Katharina Schlüter) Saraceno is also interested in human factors experiments using his existing constructions as analogue environments for living on Mars and is proposing carry out a series of workshops, experiments and solar balloon launces in White Sands desert in early 2016 in collaboration with the curator Dr Rob La Frenais, the Rubin Center at The University of Texas at El Paso and various scientific partners.

  1. The young and the clueless.

    PubMed

    Bunker, Kerry A; Kram, Kathy E; Ting, Sharon

    2002-12-01

    It's natural to promote your best and brightest, especially when you think they may leave for greener pastures if you don't continually offer them new challenges and rewards. But promoting smart, ambitious young managers too quickly often robs them of the chance to develop the emotional competencies that come with time and experience--competencies like the ability to negotiate with peers, regulate emotions in times of crisis, and win support for change. Indeed, at some point in a manager's career--usually at the vice president level--raw talent and ambition become less important than the ability to influence and persuade, and that's the point at which the emotionally immature manager will lose his effectiveness. This article argues that delaying a promotion can sometimes be the best thing a senior executive can do for a junior manager. The inexperienced manager who is given time to develop his emotional competencies may be better prepared for the interpersonal demands of top-level leadership. The authors recommend that senior executives employ these strategies to help boost their protégés' people skills: sharpen the 360-degree feedback process, give managers cross-functional assignments to improve their negotiation skills, make the development of emotional competencies mandatory, make emotional competencies a performance measure, and encourage managers to develop informal learning partnerships with peers and mentors. Delaying a promotion can be difficult given the steadfast ambitions of many junior executives and the hectic pace of organizational life. It may mean going against the norm of promoting people almost exclusively on smarts and business results. It may also mean contending with the disappointment of an esteemed subordinate. But taking the time to build people's emotional competencies isn't an extravagance; it's critical to developing effective leaders. PMID:12510540

  2. Maternal uniparental disomy for human chromosome 14, due to loss of a chromosome 14 from somatic cells with t(13; 14) trisomy 14

    SciTech Connect

    Antonarakis, S.E.; Blouin, J.L.; Maher, J.; Avramopoulos, D.; Thomas, G.; Talbot, C.C. Jr. )

    1993-06-01

    Uniparental disomy (UPD) for particular chromosomes is increasingly recognized as a cause of abnormal phenotypes in humans. The authors recently studied a 9-year-old female with a de novo Robertsonian translocation t(13;14), short stature, mild developmental delay, scoliosis, hyperextensible joints, hydrocephalus that resolved spontaneously during the first year of life, and hyperchloesterolemia. To determine the parental origin of chromosomes 13 and 14 in the proband, they have studied the genotypes of DNA polymorphic markers due to (GT)n repeats in the patient and her parents' blood DNA. The genotypes of markers D14S43, D14S45, D14S49, and D14S54 indicated maternal UPD for chromosome 14. There was isodisomy for proximal markers and heterodisomy for distal markers, suggesting a recombination event on maternal chromosomes 14. In addition, DNA analysis first revealed -- and subsequent cytogenetic analysis confirmed -- that there was mosaic trisomy 14 in 5% of blood lymphocytes. There was normal (biparental) inheritance for chromosome 13, and there was no evidence of false paternity in genotypes of 11 highly polymorphic markers on human chromosome 21. Two cases of maternal UPD for chromosome 14 have previously been reported, one with a familial rob t(13;14) and the other with a t(14;14). There are several similarities among these patients, and a [open quotes]maternal UPD chromosome 14 syndrome[close quotes] is emerging; however, the contribution of the mosaic trisomy 14 to the phenotype cannot be evaluated. The study of de novo Robertsonian translocations of the type reported here should reveal both the extent of UPD in these events and the contribution of particular chromosomes involved in certain phenotypes. 33 refs., 3 figs., 1 tab.

  3. The Beaverhead Impact Structure: Discovery and Investigation of an Allocthonous Impact Structure in SW Montana

    NASA Astrophysics Data System (ADS)

    Geissman, J. W.; Brearley, A. J.; Housen, B. A.; Fiske, P. S.; Hargraves, R.

    2003-12-01

    In 1989, Rob Hargraves identified shatter-coned sandstone cobbles in a glacial till in the Tendoy Mts., SW Montana. Subsequent investigations by Hargraves and co-workers discovered shatter cones in Precambrian sandstones and gneisses over a 25x8 km region and pseudotachylites over a more restricted region - thus defining the remains of the 50-100 km diameter, 600M to 1B year old, Beaverhead Impact Structure. Though one of 170+ impact structures identified on Earth, Beaverhead remains distinctive and important for several reasons. First, it is the only example to date of an allocthonous fragment of an impact structure, tectonically dissected and transported eastward by tens of kilometers. Second, it preserves pseudotachylies in several lithologies with varying morphologies and features (such as large vesicles) that suggest they were exhumed very quickly after formation. Finally, the orientation of shatter cones relative to sandstone bedding and cross-bedding suggests that a previously unidentified episode of tectonic deformation predated the impact (the first documented use of shatter cones as an indicator of paleo-orientation of strata). To date, nearly all the impact craters recognized on Earth retain some vestige of their original circular geometry. The discovery of Beaverhead suggests that many more meteorite impact structures may be partially preserved in orogenic belts, and that careful observation of petrologic and outcrop-scale features is the key to their discovery. Hargraves' discovery of Beaverhead (the largest impact structure yet identified in the United States) in a region already extensively mapped and studied by geologists, is only one of many examples of the insight, careful observation, and undogmatic thinking that characterized his outstanding scientific career. By bringing together regional structural geologists, planetary scientists, geophysicists and sedimentary geologists, Hargraves and his co-workers illuminated an unusual and important event

  4. Calculation of drift seepage for alternative emplacementdesigns

    SciTech Connect

    Li, Guomin; Tsang, Chin-Fu; Birkholzer, Jens

    1999-07-30

    The calculations presented in this report are performed to obtain seepage rates into drift and boreholes for two alternative designs of drift and waste emplacement at Yucca Mountain. The two designs are defined according to the Scope of Work 14012021M1, activity 399621, drafted October 6, 1998, and further refined in a conference telephone call on October 13, 1998, between Mark Balady, Jim Blink, Rob Howard and Chin-Fu Tsang. The 2 designs considered are: (1) Design A--Horizontal boreholes 1.0 m in diameter on both sides of the drift, with each borehole 8 m long and inclined to the drift axis by 30 degrees. The pillar between boreholes, measured parallel to the drift axis, is 3.3 m. In the current calculations, a simplified model of an isolated horizontal borehole 8 m long will be simulated. The horizontal borehole will be located in a heterogeneous fracture continuum representing the repository layer. Three different realizations will be taken from the heterogeneous field, representing three different locations in the rock. Seepage for each realization is calculated as a function of the percolation flux. Design B--Vertical boreholes, 1.0 m in diameter and 8.0 m deep, drilled from the bottom of an excavated 8.0 m diameter drift. Again, the drift with the vertical borehole will be assumed to be located in a heterogeneous fracture continuum, representing the rock at the repository horizon. Two realizations are considered, and seepage is calculated for the 8-m drift with and without the vertical 1-m borehole at its bottom.

  5. RapMap: a rapid, sensitive and accurate tool for mapping RNA-seq reads to transcriptomes

    PubMed Central

    Srivastava, Avi; Sarkar, Hirak; Gupta, Nitish; Patro, Rob

    2016-01-01

    Motivation: The alignment of sequencing reads to a transcriptome is a common and important step in many RNA-seq analysis tasks. When aligning RNA-seq reads directly to a transcriptome (as is common in the de novo setting or when a trusted reference annotation is available), care must be taken to report the potentially large number of multi-mapping locations per read. This can pose a substantial computational burden for existing aligners, and can considerably slow downstream analysis. Results: We introduce a novel concept, quasi-mapping, and an efficient algorithm implementing this approach for mapping sequencing reads to a transcriptome. By attempting only to report the potential loci of origin of a sequencing read, and not the base-to-base alignment by which it derives from the reference, RapMap—our tool implementing quasi-mapping—is capable of mapping sequencing reads to a target transcriptome substantially faster than existing alignment tools. The algorithm we use to implement quasi-mapping uses several efficient data structures and takes advantage of the special structure of shared sequence prevalent in transcriptomes to rapidly provide highly-accurate mapping information. We demonstrate how quasi-mapping can be successfully applied to the problems of transcript-level quantification from RNA-seq reads and the clustering of contigs from de novo assembled transcriptomes into biologically meaningful groups. Availability and implementation: RapMap is implemented in C ++11 and is available as open-source software, under GPL v3, at https://github.com/COMBINE-lab/RapMap. Contact: rob.patro@cs.stonybrook.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307617

  6. Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification

    PubMed Central

    Keating, David H.; Zhang, Yaoping; Ong, Irene M.; McIlwain, Sean; Morales, Eduardo H.; Grass, Jeffrey A.; Tremaine, Mary; Bothfeld, William; Higbee, Alan; Ulbrich, Arne; Balloon, Allison J.; Westphall, Michael S.; Aldrich, Josh; Lipton, Mary S.; Kim, Joonhoon; Moskvin, Oleg V.; Bukhman, Yury V.; Coon, Joshua J.; Kiley, Patricia J.; Bates, Donna M.; Landick, Robert

    2014-01-01

    Efficient microbial conversion of lignocellulosic hydrolysates to biofuels is a key barrier to the economically viable deployment of lignocellulosic biofuels. A chief contributor to this barrier is the impact on microbial processes and energy metabolism of lignocellulose-derived inhibitors, including phenolic carboxylates, phenolic amides (for ammonia-pretreated biomass), phenolic aldehydes, and furfurals. To understand the bacterial pathways induced by inhibitors present in ammonia-pretreated biomass hydrolysates, which are less well studied than acid-pretreated biomass hydrolysates, we developed and exploited synthetic mimics of ammonia-pretreated corn stover hydrolysate (ACSH). To determine regulatory responses to the inhibitors normally present in ACSH, we measured transcript and protein levels in an Escherichia coli ethanologen using RNA-seq and quantitative proteomics during fermentation to ethanol of synthetic hydrolysates containing or lacking the inhibitors. Our study identified four major regulators mediating these responses, the MarA/SoxS/Rob network, AaeR, FrmR, and YqhC. Induction of these regulons was correlated with a reduced rate of ethanol production, buildup of pyruvate, depletion of ATP and NAD(P)H, and an inhibition of xylose conversion. The aromatic aldehyde inhibitor 5-hydroxymethylfurfural appeared to be reduced to its alcohol form by the ethanologen during fermentation, whereas phenolic acid and amide inhibitors were not metabolized. Together, our findings establish that the major regulatory responses to lignocellulose-derived inhibitors are mediated by transcriptional rather than translational regulators, suggest that energy consumed for inhibitor efflux and detoxification may limit biofuel production, and identify a network of regulators for future synthetic biology efforts. PMID:25177315

  7. Trans-specific gene silencing between host and parasitic plants.

    PubMed

    Tomilov, Alexey A; Tomilova, Natalia B; Wroblewski, Tadeusz; Michelmore, Richard; Yoder, John I

    2008-11-01

    Species of Orobanchaceae parasitize the roots of nearby host plants to rob them of water and other nutrients. Parasitism can be debilitating to the host plant, and some of the world's most pernicious agricultural pests are parasitic weeds. We demonstrate here that interfering hairpin constructs transformed into host plants can silence expression of the targeted genes in the parasite. Transgenic roots of the hemi-parasitic plant Triphysaria versicolor expressing the GUS reporter gene were allowed to parasitize transgenic lettuce roots expressing a hairpin RNA containing a fragment of the GUS gene (hpGUS). When stained for GUS activity, Triphysaria roots attached to non-transgenic lettuce showed full GUS activity, but those parasitizing transgenic hpGUS lettuce lacked activity in root tissues distal to the haustorium. Transcript quantification indicated a reduction in the steady-state level of GUS mRNA in Triphysaria when they were attached to hpGUS lettuce. These results demonstrate that the GUS silencing signal generated by the host roots was translocated across the haustorium interface and was functional in the parasite. Movement across the haustorium was bi-directional, as demonstrated in double-junction experiments in which non-transgenic Triphysaria concomitantly parasitized two hosts, one transgenic for hpGUS and the other transgenic for a functional GUS gene. Observation of GUS silencing in the second host demonstrated that the silencing trigger could be moved from one host to another using the parasite as a physiological bridge. Silencing of parasite genes by generating siRNAs in the host provides a novel strategy for controlling parasitic weeds. PMID:18643992

  8. [Gamete donation in an in vitro fertilization program].

    PubMed

    Zhang, L Z

    1993-12-01

    Two cases of gamete donation in an IVF program were reported in this paper. In the first case the wife with recurrent abortions was found to have chromosomal abnormality, her karyotype was 45,XX,-14,-14 + rob (14 Q 14 Q). She became pregnant after IVF-ET with donated ova, and was delivered of a normal male baby on June 12, 1992. The baby's karyotype was normal. The blood group of both the husband and wife was O, while that of the baby was B. The baby suffered from icterus neonatorum as a result of ABO incompatibility but recovered quickly after treatment. Further DNA finger print analysis of the husband, wife and baby, combined with the history of egg donation IVF, proved the relationship of the parents with the baby. In the second case the husband's karyotype was 46,XY, t(4; 9) (4Q+; 9Q-). The wife had also history of recurrent abortions. Since 1989, the wife received sperm donation IUI 5 times in another hospital without success. IVF-ET with donated sperms was performed in November 1991 resulting in clinical pregnancy. She was delivered of a pair of twins, one male and one female on July 20, 1992. The possibilities of different types of gamete formation during meiosis in carriers of chromosomal balanced translocation were briefly discussed. Donation of oocytes could be realized only in an IVF program, which is also the only way to propagate for the family. However, IVF with donated sperms is indicated in women with blocked tubes besides the male factor or after repeated failures of other assisted reproductive technologies. PMID:8137642

  9. The Virtual World Presence of the International Year of Astronomy 2009

    NASA Astrophysics Data System (ADS)

    Gauthier, Adrienne J.; Huber, D.; Gay, P. L.; New Media Task Group IYA2009

    2010-01-01

    From January 2009 to January 2010, the virtual celebration of the International Year of Astronomy 2009 has come full circle side-by-side with the real world celebrations. Throughout the year, the 'Astronomy 2009' island promoted the IYA2009 within the virtual world of Second Life(R) with the goal to engage and inspire the general public in astronomy. This island is situated in the group area called SciLands, a science and technology focused mini-continent of over 60 islands. We are host to immersive exhibits for the real life projects: From Earth to the Universe, The World at Night, Dark Skies Awareness, Let There Be Night, IAAA The Artists' Universe, 365 Days of Astronomy podcast, Spitzer's MIPSGAL/GLIMPSE walkable image, and Adler Planetarium's Far Out Fridays lecture series. Spitzer Space Telescope, Chandra X-ray Observatory, and the Hubble Heritage project provided over 300 free textures in a gift pack to visitors. Other exhibits include a replica of the Lord Rosse Leviathan telescope, an astrophotography grotto featuring Adam Block, David Malin, and John Gleason's work, a functional planetarium donated by Rob Knop, and live star party events from Chico Observatory. We'll review the exhibits and live events presented throughout the past year and speak towards the plans for the future. Formative evaluation strategies and first impressions of the summative evaluation of the first year of the project will be presented. Special thanks to our sponsors: Interstellar Studios/400 Years of the Telescope, Department of Astronomy University of Arizona, Spitzer Space Telescope, Chandra X-Ray Observatory, and Helio Huet.

  10. In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.

    PubMed

    Philippe, Nadège; Maigre, Laure; Santini, Sébastien; Pinet, Elizabeth; Claverie, Jean-Michel; Davin-Régli, Anne-Véronique; Pagès, Jean-Marie; Masi, Muriel

    2015-01-01

    Infections caused by multidrug resistant (MDR) bacteria are a major concern worldwide. Changes in membrane permeability, including decreased influx and/or increased efflux of antibiotics, are known as key contributors of bacterial MDR. Therefore, it is of critical importance to understand molecular mechanisms that link membrane permeability to MDR in order to design new antimicrobial strategies. In this work, we describe genotype-phenotype correlations in Enterobacter aerogenes, a clinically problematic and antibiotic resistant bacterium. To do this, series of clinical isolates have been periodically collected from two patients during chemotherapy with imipenem. The isolates exhibited different levels of resistance towards multiple classes of antibiotics, consistently with the presence or the absence of porins and efflux pumps. Transport assays were used to characterize membrane permeability defects. Simultaneous genome-wide analysis allowed the identification of putative mutations responsible for MDR. The genome of the imipenem-susceptible isolate G7 was sequenced to closure and used as a reference for comparative genomics. This approach uncovered several loci that were specifically mutated in MDR isolates and whose products are known to control membrane permeability. These were omp35 and omp36, encoding the two major porins; rob, encoding a global AraC-type transcriptional activator; cpxA, phoQ and pmrB, encoding sensor kinases of the CpxRA, PhoPQ and PmrAB two-component regulatory systems, respectively. This report provides a comprehensive analysis of membrane alterations relative to mutational steps in the evolution of MDR of a recognized nosocomial pathogen.

  11. Sinkhole formation above underground limestone quarries: A case study in South Limburg (Belgium)

    NASA Astrophysics Data System (ADS)

    Van Den Eeckhaut, M.; Poesen, J.; Dusar, M.; Martens, V.; Duchateau, Ph.

    2007-10-01

    Historical records were used for the compilation of a database of sinkholes resulted from collapses of abandoned shallow underground limestone quarries (mines) in two villages in Belgian South Limburg. During the last 350 years the formation of such sinkholes caused at least 38 casualties, but more often it caused a change in topography and damage to public and private property. The objective of this study is to better understand the spatial and temporal patterns of quarry collapse-related sinkholes in the study area. Apart from sinkhole locations and ages, the compiled database provides information on the dimensions of the area affected and the damage caused by sinkhole formation, as well as the causal factors of sinkholes. One hundred seventy-three sinkholes have been reported since 1665, but most (80%) reported sinkholes postdate 1965. Sinkhole dimensions provided information on the type of collapse. Seven large sinkholes, displacing a total sediment volume of 480,000 m 3, resulted from large-scale roof breakdown after pillar failure. The smaller sinkholes were the result of fall of the overburden into galleries after local roof collapse or suffosion of a solution pipe. In total, these small sinkholes displaced 12,300 m 3 of sediment. At present almost all large underground quarries in the study area have been affected by sinkholes. These features were caused by natural and anthropogenic factors, and occur in zones with thin roofs, where pillars were affected by pillar robbing, or on locations with inappropriate sewerage systems above quarries. The formation of sinkholes was often reported in spring during years with high moisture contents in the overburden, caused by high groundwater recharge or above average precipitation. With increasing time since quarry abandonment, quarries become more susceptible to pillar creep and bending of the roof. Hence, if no appropriate mitigation measures are taken to reduce such deterioration processes, the number of sinkholes

  12. Lessons for electricity from other restructured industries

    SciTech Connect

    Ellig, J.

    1995-09-01

    These results of deregulation in other industries help put Rob Bradley`s remarks in a broader context. In particular, they should aid in dispelling the notion that electricity is the one unique industry where competition cannot succeed. Instead, there are striking similarities between electricity and other network industries: The electric industry involves several stages, some of which employ production technology that involves large economies of scale and high sunk costs. This is also true of the natural gas, railroad, telecommunications, airline, and trucking industries. Some activities at the various stages in the electric industry must be closely synchronized to ensure safe and reliable service. This is also true in the other network industries; for example, airline flights must be carefully synchonized through the air traffic control system. Public policy toward electricity has evolved through various stages: open competition, limited regulation, and comprehensive regulation. We now seem on the verge of supply deregulation, and this is consistent with the experience of other network industries. Given these similarities, the direction of Bradley`s predictions and prescriptions seems justified (though we may never reach the {open_quotes}End of Regulatory History.{close_quotes}) Across diverse industries, deregulation and competition have generated some common results: lower price levels, price reductions for most customer groups, expanded sales, and improved or unchanged quality of service. In each case, critics argued that deregulation would not work because of special industry characteristics. Thus far, we have yet to find the special industry in which deregulation promotes higher prices or poor service. With this experience in mind, it`s safe to say that political influence over the electric industry should shrink greatly in the years ahead, even if it doesn`t disappear completely.

  13. Narrow-band Filter Observations of the Red-Line Corona at the 29 March 2006 Eclipse

    NASA Astrophysics Data System (ADS)

    Rust, David M.; Noble, M. W.; Pasachoff, J. M.; Babcock, B. A.; Bruck, M. A.; Wittenmyer, R. A.

    2006-06-01

    We report on observations of the corona above active region NOAA 10866, which was on the solar east limb at S 06 on 29 March 2006. Filtergrams were obtained at six 0.22 Å steps across the profile of the Fe X line at 6374.5 Å during the total solar eclipse, starting at about 1052 UT. The telescope was a 35-cm Schmidt-Cassegrain Meade RCX400 with the solar image relayed to a 512 x 512-pixel Andor Ixon DV887 CCD camera via telecentric optics and two narrow-bandpass filters: (1) a 2 Å thin-film Andover Corp. blocker and (2) a 0.16 Å tunable Fabry-Perot etalon, made by the CSIRO Australian Centre for Precision Optics. The F-P etalon is a Y-cut lithium niobate wafer of 0.200-mm thickness coated with reflective and conductive thin-film layers. Application of a voltage to the etalon produces a passband shift of 0.0011 Å/volt. Calibration at the eclipse site in Kastellorizo, Greece, was maintained by reference to a WSTech thermo-electrically stabilized diode laser tuned to 6375.16 Å. The profile and Doppler shifts of the Fe X line will be discussed.The expedition was supported by NSF (ATM-0552116), the Committee for Research and Exploration of the National Geographic Society, NASA's Planetary Astronomy Division for the CCD cameras (NNG04GE48G), Sigma Xi, and the Rob Spring Fund and the Ryan Patrick Gaishin Fund at Williams College.

  14. Elastic, not plastic species: Frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organisms

    PubMed Central

    2010-01-01

    Background Darwin's evolutionary theory could easily explain the evolution of adaptive traits (organs and behavioral patterns) in asexual but not in sexual organisms. Two models, the selfish gene theory and frozen plasticity theory were suggested to explain evolution of adaptive traits in sexual organisms in past 30 years. Results The frozen plasticity theory suggests that sexual species can evolve new adaptations only when their members are genetically uniform, i.e. only after a portion of the population of the original species had split off, balanced on the edge of extinction for several generations, and then undergone rapid expansion. After a short period of time, estimated on the basis of paleontological data to correspond to 1-2% of the duration of the species, polymorphism accumulates in the gene pool due to frequency-dependent selection; and thus, in each generation, new mutations occur in the presence of different alleles and therefore change their selection coefficients from generation to generation. The species ceases to behave in an evolutionarily plastic manner and becomes evolutionarily elastic on a microevolutionary time-scale and evolutionarily frozen on a macroevolutionary time-scale. It then exists in this state until such changes accumulate in the environment that the species becomes extinct. Conclusion Frozen plasticity theory, which includes the Darwinian model of evolution as a special case - the evolution of species in a plastic state, not only offers plenty of new predictions to be tested, but also provides explanations for a much broader spectrum of known biological phenomena than classic evolutionary theories. Reviewers This article was reviewed by Rob Knight, Fyodor Kondrashov and Massimo Di Giulio (nominated by David H. Ardell). PMID:20067646

  15. SCR atmosphere induced reduction of oxidized mercury over CuO-CeO2/TiO2 catalyst.

    PubMed

    Li, Hailong; Wu, Shaokang; Wu, Chang-Yu; Wang, Jun; Li, Liqing; Shih, Kaimin

    2015-06-16

    CuO-CeO2/TiO2 (CuCeTi) catalyst synthesized by a sol-gel method was employed to investigate mercury conversion under a selective catalytic reduction (SCR) atmosphere (NO, NH3 plus O2). Neither NO nor NH3 individually exhibited an inhibitive effect on elemental mercury (Hg(0)) conversion in the presence of O2. However, Hg(0) conversion over the CuCeTi catalyst was greatly inhibited under SCR atmosphere. Systematic experiments were designed to investigate the inconsistency and explore the in-depth mechanisms. The results show that the copresence of NO and NH3 induced reduction of oxidized mercury (Hg(2+), HgO in this study), which offset the effect of catalytic Hg(0) oxidation, and hence resulted in deactivation of Hg(0) conversion. High NO and NH3 concentrations with a NO/NH3 ratio of 1.0 facilitated Hg(2+) reduction and therefore lowered Hg(0) conversion. Hg(2+) reduction over the CuCeTi catalyst was proposed to follow two possible mechanisms: (1) direct reaction, in which NO and NH3 react directly with HgO to form N2 and Hg(0); (2) indirect reaction, in which the SCR reaction consumed active surface oxygen on the CuCeTi catalyst, and reduced species on the CuCeTi catalyst surface such as Cu2O and Ce2O3 robbed oxygen from adjacent HgO. Different from the conventionally considered mechanisms, that is, competitive adsorption responsible for deactivation of Hg(0) conversion, this study reveals that oxidized mercury can transform into Hg(0) under SCR atmosphere. Such knowledge is of fundamental importance in developing efficient and economical mercury control technologies for coal-fired power plants.

  16. Aging and Urbanization: The Neighborhood Perception and Functional Performance of Elderly Persons in Belo Horizonte Metropolitan Area-Brazil.

    PubMed

    Ferreira, Fabiane Ribeiro; César, Cibele Comini; Camargos, Vitor Passos; Lima-Costa, Maria Fernanda; Proietti, Fernando Augusto

    2010-01-01

    Currently, half of the world population resides in cities. The percentage of world population that is elderly is expected to double from 11% to 22% by 2050 and will be concentrated in urban areas of developing countries. The purpose of this study was to evaluate the functional status of elderly who live in the Belo Horizonte Metropolitan Area, Minas Gerais State, Brazil. The International Classification of Functioning, Disability and Health (ICF) was employed as the theoretical model. Probabilistic sampling was used to select 1,611 elderly persons (defined as >/=60 years) for the study. The response variable "functional performance" was developed by counting the number of basic and instrumental activities of daily living (ADL) that subjects found difficult to carry out. A zero-inflated negative binomial (ZINB) regression model was fitted to the data. The prevalence of disability was 47.1%. Neighborhood self-perception revealed that 84.0% of the elderly were satisfied with their neighborhood, although only 18.4% trusted people around them. Concerns about walking around the neighborhood were: fear of being robbed (78.0%) and fear of falling due to sidewalk defects (48.2%), which caused a 62% increase in the number of ADL carried out with difficulty. It is well known that there is a continuous tendency for functional results to improve as the frequency of walking increases. Thus, urban infrastructure interventions, such as improving public sidewalks, might influence the frequency of elderlies walking in their neighborhoods. Making walking possible-or even pleasant-could increase their social participation and use of services. PMID:19924540

  17. The very real dangers of executive coaching.

    PubMed

    Berglas, Steven

    2002-06-01

    A personal coach to help your most promising executives reach their potential--sounds good, doesn't it? But, according to Steven Berglas, executive coaches can make a bad situation worse. Because of their backgrounds and biases, they ignore psychological problems they don't understand. Companies need to consider psychotherapeutic intervention when the symptoms plaguing an executive are stubborn or severe. Executives with issues that require more than coaching come in many shapes and sizes. Consider Rob Bernstein, an executive vice president of sales at an automotive parts distributor. According to the CEO, Bernstein had just the right touch with clients but caused personnel problems inside the company. The last straw came when Bernstein publicly humiliated a mail clerk who had interrupted a meeting to ask someone to sign for a package. At that point, the CEO assigned Tom Davis to coach Bernstein. Davis, a former corporate lawyer, worked with Bernstein for four years. But Davis only exacerbated the problem by teaching Bernstein techniques for "handling" employees--methods that were condescending at best. While Bernstein appeared to be improving, he was in fact getting worse. Bernstein's real problems went undetected, and when his boss left the company, he was picked as the successor. Soon enough, Bernstein was again in trouble, suspected of embezzlement. This time, the CEO didn't call Davis; instead, he turned to the author, a trained psychotherapist, for help. Berglas soon realized that Bernstein had a serious narcissistic personality disorder and executive coaching could not help him. As that tale and others in the article teach us, executives to be coached should at the very least first receive a psychological evaluation. And company leaders should beware that executive coaches given free rein can end up wreaking personnel havoc.

  18. In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

    PubMed Central

    Santini, Sébastien; Pinet, Elizabeth; Claverie, Jean-Michel; Davin-Régli, Anne-Véronique; Pagès, Jean-Marie; Masi, Muriel

    2015-01-01

    Infections caused by multidrug resistant (MDR) bacteria are a major concern worldwide. Changes in membrane permeability, including decreased influx and/or increased efflux of antibiotics, are known as key contributors of bacterial MDR. Therefore, it is of critical importance to understand molecular mechanisms that link membrane permeability to MDR in order to design new antimicrobial strategies. In this work, we describe genotype-phenotype correlations in Enterobacter aerogenes, a clinically problematic and antibiotic resistant bacterium. To do this, series of clinical isolates have been periodically collected from two patients during chemotherapy with imipenem. The isolates exhibited different levels of resistance towards multiple classes of antibiotics, consistently with the presence or the absence of porins and efflux pumps. Transport assays were used to characterize membrane permeability defects. Simultaneous genome-wide analysis allowed the identification of putative mutations responsible for MDR. The genome of the imipenem-susceptible isolate G7 was sequenced to closure and used as a reference for comparative genomics. This approach uncovered several loci that were specifically mutated in MDR isolates and whose products are known to control membrane permeability. These were omp35 and omp36, encoding the two major porins; rob, encoding a global AraC-type transcriptional activator; cpxA, phoQ and pmrB, encoding sensor kinases of the CpxRA, PhoPQ and PmrAB two-component regulatory systems, respectively. This report provides a comprehensive analysis of membrane alterations relative to mutational steps in the evolution of MDR of a recognized nosocomial pathogen. PMID:26398358

  19. AIDS. Grim news for Asia.

    PubMed

    1992-12-01

    While Asia was the last region to be exposed to the global spread of HIV and AIDS, the incidence of HIV infection there is increasing fastest. The Asian Development Bank predicts mortality from AIDS will cause some town and village populations to begin declining by the year 2000. With an estimated 1 million people infected in India, and 400,000 in Thailand, these 2 countries are particularly exposed to the risk of epidemic HIV spread. In 5 years, more people may be affected by AIDS in India than anywhere else in the world. Concern over a growing presence of HIV is also merited for the Philippines, Indonesia, China, and the drug trade's Golden Triangle. The Second International Conference on AIDS in Asia and the Pacific in November 1992 stressed that AIDS no longer affects only homosexual and IV drug using populations. 50% of new infections worldwide in the first half of 1992 were among women, 65% of Thailand's AIDS cases are among heterosexuals, and 3-5% of Thailand's long-haul truck drivers have tested positive for HIV infection. HIV and AIDS robs economies and societies of their best workers. The immediate costs of caring for AIDS patients will pale next to the far greater losses to be realized in private sector economic productivity. Asia's more developed economies will probably be able to survive the epidemic, but small, poor countries like Laos will wilt. Prompt action must be taken to overcome public and religious ignorance and objections to promoting and using condoms throughout the region. For the first time, Beijing has organized an AIDS awareness conference for male homosexuals. Further, Singapore has implemented compulsory testing for lower-income foreign workers. Pakistan has even solicited educational assistance and support from Islamic religious leaders; similar action is being considered in Bangladesh.

  20. STRUCTURAL BIOLOGY AND MOLECULAR MEDICINE RESEARCH PROGRAM (LSBMM)

    SciTech Connect

    Eisenberg, David S.

    2008-07-15

    . The development of publicly accessible, web-based servers, including the HOTPATCH server, the ProKnow Server and the SAVEs server. All of these are accessible from the home page of the Institute. Advancing the science of bioenergy, in the laboratories of the Principal Investigators of the Institute, including the laboratories of Shimon Weiss, James Liao, James Bowie, Todd Yeates, Rob Gunsalus.